gebhart/patrepeval huggingface dataset:
OTHR-16. MOLECULAR PROFILING USING THE 92-GENE ASSAY FOR TUMOR CLASSIFICATION OF BRAIN METASTASES (2019)

Abstract BACKGROUND: Nearly 200,000 patients are diagnosed with brain metastases in the US annually. Advances in targeted therapies make definitive diagnosis of the primary tumor type important but can be challenging in many patients. The 92-gene assay is a validated gene expression classifier of 50 tumor types for patients with uncertain tissue of origin diagnoses. Results from a clinical series of brain biopsies and potential impact on treatment were evaluated. METHODS: An IRB approved, de-identified database of clinical and molecular information from biopsies (N = 24,486) submitted for testing with the 92-gene assay (CancerTYPE ID, Biotheranostics, Inc.) as part of routine care were reviewed. Descriptive analysis included patient demographics and molecular diagnoses. RESULTS: Analysis included 464 brain biopsies. A molecular diagnosis was provided in 433 (93.3%) tested (&amp;lt; 5% assay failure rate) with 24 different tumor types. Six primary tumor types made up the majority (67.4%) with almost one-third of the molecular predictions being Lung (31.2%), followed by Neuroendocrine (NET) (9.9%), Sarcoma (7.9%), Skin (6.4%), Gastroesophageal (6.2%), and Urinary bladder (5.8%). All of these 6 tumor types, for which activity in the CNS has been documented, have immune checkpoint inhibitors or other targeted therapies approved in selected cases by the US Federal Drug Administration (FDA). CONCLUSIONS: Molecular classification of brain metastases can identify distinct tumor types for which there are FDA approved targeted medications. Improving diagnostic precision with the 92-gene assay helps identify a subset of therapy-responsive metastatic brain tumors, thus improving therapy and possibly providing better outcomes and survival.
Purine and Pyrimidine (P2) Receptors as Drug Targets (2002)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTPurine and Pyrimidine (P2) Receptors as Drug TargetsKenneth A. Jacobson, Michael F. Jarvis, and Michael WilliamsView Author Information Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, and Department of Molecular Pharmacology and Biological Chemistry, Northwestern University School of Medicine, Chicago, Illinois 60611 Cite this: J. Med. Chem. 2002, 45, 19, 4057–4093Publication Date (Web):August 20, 2002Publication History Received30 January 2002Published online20 August 2002Published inissue 1 September 2002https://pubs.acs.org/doi/10.1021/jm020046yhttps://doi.org/10.1021/jm020046yreview-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views2653Altmetric-Citations280LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Agonists,Antagonists,Monomers,Receptors,Rodent models Get e-Alerts
Quadratic solitons with gain and loss (1999)

Propagation of soliton signals in quadratic nonlinear media under conditions for second-harmonic generation in the presence of multiple-frequency-band absorption and amplification is addressed. The reshaping and energy redistribution of the multiple-frequency solitons under the action of the single-band loss and gain is investigated and shown in detail. New chirped localized solitary-wave solutions that exactly compensate loss and gain are presented. Practical implementation conditions are discussed.
Bird‐biting mosquitoes on farms in southern England (2018)

Mosquitoes that blood-feed on avian hosts are important vectors of many arthropod-borne viruses (arboviruses). In Europe, these include West Nile virus (WNV), Usutu virus (USUTV) and Sindbis virus. These are all maintained in enzootic bird-mosquito-bird cycles and are important veterinary and medical threats to the UK. Principally, veterinary concerns lie with the risks to domestic animals, such as the incidental spillover infection of horses with WNV which may lead to serious neurological sequelae. Wildlife may also be affected, with certain wild birds being highly susceptible to infection and death with USUTV, although poultry are less susceptible. To date, UK surveillance for these viruses has not yielded evidence of active virus transmission although serological evidence has been reported.
Chromosome band 16q22‐linked familial AML: Exclusion of candidate genes, and possible disease risk modification by NQO1 polymorphisms (2004)

Analyses of chromosomal translocation and inversion breakpoints in sporadic acute myeloid leukemias have identified many transcription factors as playing a role in leukemogenesis. Studies of families with a Mendelian predisposition to hematological malignancies have identified the gene coding for the transcription factor RUNX1 as a leukemia-predisposing gene involved in the first steps of leukemogenesis. Using two families, another autosomal dominant familial leukemia locus was linked to chromosome band 16q22 where the CBFB gene maps. Although CBFB forms a core-binding factor transcriptional complex with RUNX1, previous analyses have excluded the CBFB gene as the leukemia-predisposing gene in these families. In the current study, we performed an extended molecular analysis in these families of the four other transcription factor genes in the 16q22 critical region as well as of two other genes with a known association with leukemia. Several previously undescribed but nonpathogenic sequence variants were identified. We demonstrated that the transcription factors E2F4, CTCF, NFATC3, and NFAT5, and the genes coding for NAD(P)H:quinone oxido-reductase 1 (NQO1) and for E-cadherin are not responsible for the leukemia susceptibility in these families. The presence of NQO1 polymorphisms may suggest a role for this gene in disease risk modification in these families.
Application of the CALUX bioassay for epidemiological study: analyses of Belgian human plasma (2004)

peer reviewed
México em Sangue: A construção da imagem do comunistapela imprensa brasileira dos anos 30 (2000)

Resumen en: This article is about the political environment in Brazil in the 1930 decade, during the Getulio Vargas regime. It recounts the discourse proclaimed by t...
A Destructive Validation of NDE Responses of Service-Induced PWSCC Found in North Anna 2 Control Rod Drive Nozzle 31 (2009)

Studies conducted at the Pacific Northwest National Laboratory (PNNL) in Richland, Washington focused on assessing the effectiveness of nondestructive examination (NDE) techniques for inspecting control rod drive mechanism (CRDM) nozzles and J-groove weldments. The primary objective of this work is to provide information to the United States Nuclear Regulatory Commission (NRC) on the effectiveness of NDE methods as related to the in-service inspection of CRDM nozzles and J-groove weldments, and to enhance the knowledge base of primary water stress corrosion cracking (PWSCC) through destructive characterization of the CRDM assemblies.
Field measurements of SOP transients in OPGW, with time and location correlation to lightning strikes (2017)

We monitored the state of polarization (SOP) of polarized light in an optical ground wire (OPGW) link located in North America using a test method and apparatus that measured Stokes space angular velocity and geographic location of SOP transients. We observed transients up to 5.1 Mrad/s and were able to correlate these events in both time and location to lightning strikes documented by the United States Precision Lightning Network (USPLN).
Le grand dérangement (2005)

Le Grand dérangement contemporain marque le passage d\'un passé défait à un présent où le devenir se produit dans une transformation continue sans achèvements identifiables. Se plaçant en observateur décentré, attentif aux transformations contemporaines, l\'auteur propose des interprétations inédites. Il dénonce les défaillances de l\'action civilisatrice, la montée continue de la puissance, les réactions à l\'expansion de la surmodernité mondialisante. Cet essai incisif et engagé \
Synthesis and luminescent properties of novel red-emitting Eu(III) complexes based on alanine aliphatic derivatives with different optical rotation (2020)

Abstract A series of novel luminescent amino acid-rare earth complexes (denoted as Eu(L/D-SA) 3 -Phen) have been successfully synthesized. Using stearoyl alanine (denoted as SA) with different optical rotations as the first ligand and 1,10-phenanthroline (Phen) as the second ligand, the products were prepared by solution chemical reaction. Fourier transform infrared spectrometer (FT-IR), nuclear magnetic resonance spectroscopy ( 1 H NMR), x-ray diffraction (XRD), scanning electron microscope (SEM), ultraviolet and visible spectrum (UV) and photoluminescence spectroscopy were used to characterize the properties of Eu(L/D-SA) 3 -Phen. FT-IR, 1 H NMR and XRD indicate that ligand SA and Phen were prepared and successfully combined with Eu 3+ ions. SEM analysis shows relatively uniform morphological structure. Eu(L/D-SA) 3 -Phen exhibit a typical luminescence emission peak at 614 nm. In addition, the lifetimes of Eu(L/D-SA) 3 -Phen are in scale of millisecond. The relationship between fluorescence intensity of Eu(L/D-SA) 3 -Phen and the optical rotation of ligand SA has been studied and discussed. Based on the results, Eu(L/D-SA) 3 -Phen have excellent luminescent performance and possess potential application as luminescent materials.
Effects of secondary electron emission from the ceramic walls on the discharge of Hall effect thrusters using a 2D PIC simulation (2018)

International audience
Optoelectronic properties of black silicon fabricated by femtosecond laser in ambient air: exploring a large parameter space (2023)

We study the surface morphology, optical absorption (400-1100 nm), and carrier lifetime of black silicon fabricated by femtosecond (fs) laser in air. We explore a large laser parameter space, for which we adopt a single parameter ξ to describe the cumulative fluence delivered to the sample. We also study the laser-oxidized surface layer by measuring its photoluminescence spectra and comparing its effect on the aforementioned properties. Our study in a broad range of ξ is instructive in choosing laser parameters when targeting different applications.
Antioxidant strategies in protection against neurodegenerative disorders (2003)

The most common neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease and stroke; they are devastating clinical problems which lack effective treatments. Although the aetiology of these diseases is not fully understood, oxidative stress is believed to be a contributing causative factor. In addition to conventional therapies, antioxidant strategies in protection against neurodegenerative conditions have been increasingly addressed, as evidenced by an increasing number of animal studies, clinical reports and patents regarding these processes in recent years. The effectiveness of antioxidants in protecting against neurodegenerative disorders lies mainly in their ability to cross the blood–brain barrier, their potential in terms of subcellular distribution occurring in membranes, in the cytoplasm and especially in mitochondria, and their multifunctional capacity as well as their synergistic actions. The naturally occurring antioxidants with different properties collaborate as an array to defend against oxidative stress. Single antioxidant supplementation would not then be expected to have a remarkable influence on neurodegenerative diseases, which may involve free radicals. Thus, using combinations of antioxidants with different subcellular distributions and different properties for prophylaxis or treatment would probably improve therapeutic outcomes. Based on their multifactoral aetiology, the development of novel antioxidants with anti-inflammatory and metal-chelating properties and the ability to improve metabolism, for example by increasing ATP production rate or a new formulation of antioxidants with other agents, which have different functions, will become the new strategies in protecting against neurodegenerative disorders.
ChemInform Abstract: A Facile Synthesis of 2‐O‐(α‐D‐Mannopyranosyl)‐α‐D‐ mannopyranosides. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Silver Diamine Fluoride: A Successful Anticarious Solution with Limits (2018)

Silver diamine fluoride (SDF) is a solution containing ionic silver, fluoride, and ammonia that arrests the progress of carious lesions and prevents the development of future caries. The silver particle extends into the dentin tubules and could create some bonding problems for subsequent composite resin restorations placed over SDF-treated darkened tooth structures. The fluoride penetrates deeper into the tooth with SDF as compared with other fluoride solutions, creating a fluoride reservoir in the tooth structure. The fluoride component of SDF contributes to remineralization and fluorapatite formation, producing harder, more caries-resistant tooth structures. The silver provides the antimicrobial activity for the material and inhibits biofilm formation. It has been evaluated in >20 clinical studies and reviewed in systemic reviews. The material was recently approved by the Food and Drug Administration for desensitizing cold-sensitive teeth and has been used off-label to treat carious lesions. SDF will produce a caries lesion darker (brown to black) than the original, which is the major criticism of the material. A nanoparticle-sized silver material was recently developed that may retain the antimicrobial properties of the larger-sized ion silver material without the discoloring effects. The application of SDF is easily adapted for field use. The lesion is isolated, and the solution is painted onto the clean caries lesion and dried. This simple application process requires little equipment, and its low cost per application makes the material ideal for large populations.
In Vivo Monitoring of the Antiangiogenic Effect of Neurotensin Receptor-Mediated Radiotherapy by Small-Animal Positron Emission Tomography: A Pilot Study (2014)

The neurotensin receptor (NTS1) has emerged as an interesting target for molecular imaging and radiotherapy of NTS-positive tumors due to the overexpression in a range of tumors. The aim of this study was to develop a 177Lu-labeled NTS1 radioligand, its application for radiotherapy in a preclinical model and the imaging of therapy success by small-animal positron emission tomography (µPET) using [68Ga]DOTA-RGD as a specific tracer for imaging angiogenesis. The 177Lu-labeled peptide was subjected to studies on HT29-tumor-bearing nude mice in vivo, defining four groups of animals (single dose, two fractionated doses, four fractionated doses and sham-treated animals). Body weight and tumor diameters were determined three times per week. Up to day 28 after treatment, µPET studies were performed with [68Ga]DOTA-RGD. At days 7-10 after treatment with four fractionated doses of 11-14 MBq (each at days 0, 3, 6 and 10), the tumor growth was slightly decreased in comparison with untreated animals. Using a single high dose of 51 MBq, a significantly decreased tumor diameter of about 50% was observed with the beginning of treatment. Our preliminary PET imaging data suggested decreased tumor uptake values of [68Ga]DOTA-RGD in treated animals compared to controls at day 7 after treatment. This pilot study suggests that early PET imaging with [68Ga]DOTA-RGD in radiotherapy studies to monitor integrin expression could be a promising tool to predict therapy success in vivo. Further successive PET experiments are needed to confirm the significance and predictive value of RGD-PET for NTS-mediated radiotherapy.
New POMT2 mutations causing congenital muscular dystrophy (2007)

Our results broaden the clinical spectrum associated with POMT2 mutations, which should be considered in patients with CMD associated with microcephaly, and severe mental retardation with or without ocular involvement.
Reliability Engineering in the Twenty‐First Century (2014)

This chapter presents the basic definitions of reliability and discusses the relationship between quality, reliability, and performance. Reliability pertains to the ability of a product to perform without failure and within specified performance limits for a specified time in its life-cycle application conditions. Performance and quality are related to reliability. Performance parameters typically describe the functional capabilities of a product. Quality parameters are commonly used to assess the manufacturing goodness and the ability of a product to work when first received by the customer. Product quality can impact product reliability. Reliability engineering deals with preventing, assessing, and managing failures. The tools of reliability engineers include statistics, probability theory, and many fields of engineering and the sciences related to the problem domain. The chapter presents the consequences of having an unreliable product. It concludes with a discussion of supplier–customer reliability objectives and responsibilities.
Use of Single‐Walled Carbon Nanotubes as Reinforcing Fillers in UV‐Curable Epoxy Systems (2008)

Abstract CNT were dispersed in an epoxy matrix and cured by means of UV light. An increase on elastic modulus and T g values was measured by DMTA analysis and attributed to the constraint effect of CNT on polymer chain mobility. Excellent scratch resistant coatings characterized by high critical load, small cracks and high recovery were obtained in the presence of a very low CNT content (0.025 wt.‐%). TEM analysis showed some isolated CNT and some cluster agglomerations of size of about 250 nm. It was shown that it was possible to decrease the surface resistivity of the cured samples by three orders of magnitude in the presence of 0.1 wt.‐% of SWCNT content. magnified image
Multilevel Analysis of the Physical Health Perception of Employees: Community and Individual Factors (2012)

Communities do have a modest association with SRH of the employees living there. After adjusting for individual-level and demographic variables, employees living in less/moderately deprived communities are more likely to perceive better physical health relative to those who live in highly deprived communities.
Topical therapy and the development of silver sulfadiazine. (1983)

Topical therapy is a selective approach to the prevention and treatment of infection in burns and other surgical wounds. Effective compounds possess certain chemical and physical properties. Prerequisites include low solubility, slow absorption, nonreactivity with wound exudates, proteins and ions and ability to achieve prolonged antimicrobial activity in the wound. These compounds yield much higher levels in the zone of infection than can be achieved by diffusion into the wound after systemic administration. The wide spectrum of antibacterial activity, the low toxicity, minimal tissue reaction, ease of application suggest that topical silver sulfadiazine therapy can safely be extended to other wound infections, wound covers and certain transplant materials.
Explosive onset of continuous wave laser tissue ablation (1990)

The phenomena at the onset of and during tissue ablation using continuous wave lasers were studied. Aortic and myocardial bovine tissues were exposed in air and in water to Nd-YAG (10 to 60 W) and argon (3.5 W) laser light. The transmitted light was measured, the surface of the tissue was filmed and the tissue was processed for histology. Three distinct phases were observed. Phase A was tissue denaturation. Phase B started with explosive vaporisation ('popcorn') in conjunction with a drop of about 50% in light transmission due to enhanced reflection and scattering. The 'popcorn' is possibly associated with a layered structure of the tissue. Phase C started with carbonisation of the tissue beginning in the centre and expanding in a cyclic fashion while the tissue was vaporised leaving a crater. Forward light transmission did not decrease. Thin layers of carbon (20 microns) and vacuoles (30 microns) suggested a large temperature gradient along the tissue ablation front. The ablation velocity was constant (r greater than 0.92) and tissue dependent. Reported models on laser tissue ablation need to be extended to include explosive vaporisation ('popcorn') at the onset and cyclic carbonisation during steady-state crater formation.
Three-Dimensional Stapes Footplate Motion in Human Temporal Bones (2003)

The literature provides conflicting information on whether the motion of the stapes footplate is piston-like or some other type of motion, such as rotational or rocking. Examination of the three-dimensional (3D) motion of the stapes footplate appears to be an excellent way to understand this complicated motion. Five microsphere reflective targets were placed on the stapes footplate in ten fresh human cadaver temporal bone preparations, and their vibration measured through an extended facial recess approach using a laser Doppler vibrometer. The five target sites on the stapes footplate were center, anterior, posterior, superior and inferior. The stimulus was a sound input of 80-120 dB SPL at the tympanic membrane over a frequency range of 0.1 to 10 kHz. The 3D motion of the stapes footplate was calculated using the velocity amplitude and phase obtained for each target. For frequencies up to 1.0 kHz the vibration of the stapes footplate was primarily piston-like; this motion became complex at higher frequencies, with rotary motion along both the long and short axis of the footplate. When the cochlea was drained, stapes footplate motion became essentially piston-like for all frequencies.
iLearn on the iPhone: Real-Time Human Activity Classification on Commodity Mobile Phones (2008)

As computing moves beyond the desktop, human activity becomes an essential component of many applications. Activity classification is an active research area and several research systems have been constructed. Most have focused on fragile custom hardware only available in limited quantities. We instead seek to use commodity hardware to lower the barrier to creating activity-informed mobile applications. We describe iLearn, our system for classifying human activities using the Apple iPhone‟s three-axis accelerometer and the Nike+iPod Sport Kit. Our results suggest activities including running, walking, bicycling, and sitting can be recognized at accuracies of 97% without any training by an end-user.