gebhart/patrepeval huggingface dataset:
Prediction of antimicrobial peptides using hyperparameter optimized support vector machines (2011)

Antimicrobial peptides (AMPs) play a key role in the innate immune response.They can be ubiquitously found in a wide range of eukaryotes including mammals, amphibians, insects, plants, and protozoa.In lower organisms, AMPs function merely as antibiotics by permeabilizing cell membranes and lysing invading microbes.Prediction of antimicrobial peptides is important because experimental methods used in characterizing AMPs are costly, time consuming and resource intensive and identification of AMPs in insects can serve as a template for the design of novel antibiotic.In order to fulfil this, firstly, data on antimicrobial peptides is extracted from UniProt, manually curated and stored into a centralized database called dragon antimicrobial peptide database (DAMPD).Secondly, based on the curated data, models to predict antimicrobial peptides are created using support vector machine with optimized hyperparameters.In particular, global optimization methods such as grid search, pattern search and derivative-free methods are utilised to optimize the SVM hyperparameters.These models are useful in characterizing unknown antimicrobial peptides.Finally, a webserver is created that will be used to predict antimicrobial peptides in haemotophagous insects such as Glossina morsitan and Anopheles gambiae.
Antigen-specific immune response in mice. (2016)

&lt;p&gt;&lt;b&gt;&lt;i&gt;(A)&lt;/i&gt;&lt;/b&gt; Virus-neutralizing (VN) antibody titers in the serum of female BALB/c mice were measured using Fluorescent Antibody Virus Neutralization (FAVN) test. Animals were vaccinated twice with 80 μg RABV-G mRNA or buffer at day 0 and 21. 35 days after the first vaccination, serum was collected. The dotted line at 0.5 IU/ml is considered as a correlate of protection. &lt;b&gt;&lt;i&gt;(B)&lt;/i&gt;&lt;/b&gt; Splenocytes from the same mice were isolated for the analysis of antigen specific T cells via ELISPOT analysis at day 35 after the first immunization. &lt;b&gt;&lt;i&gt;(C&lt;/i&gt;, &lt;i&gt;D)&lt;/i&gt;&lt;/b&gt; VN titers dose-response profile in female &lt;b&gt;&lt;i&gt;(C)&lt;/i&gt;&lt;/b&gt; C57BL/6 and &lt;b&gt;&lt;i&gt;(D)&lt;/i&gt;&lt;/b&gt; BALB/c mice after RABV-G mRNA vaccination compared to licensed vaccines. Animals were vaccinated with RABV-G mRNA, licensed vaccines (HDC or Rabipur (LIC)) or buffer on study days 0 and 21. RABV-G mRNA was applied intradermally (i.d.) at doses of 80 μg, 40 μg, 20 μg, 10 μg, 5 μg, 2.5 μg or 1.25 μg. For positive control, 100 μl (0.1 human dose) of Rabipur and HDC were administered intramuscularly (i.m.). Presence of rabies-specific VN titers in sera of vaccinated and control mice were analyzed 2 weeks after immunization using the FAVN test. In both graphs the mean and standard deviation (SD) is plotted and significance compared to buffer treated mice was analysed using one-way ANOVA Dunnett’s multiple comparisons test (* p&lt;0.01). &lt;b&gt;&lt;i&gt;(E)&lt;/i&gt;&lt;/b&gt; Kinetic of virus-neutralizing antibodies in BALB/c mice from &lt;b&gt;&lt;i&gt;(D)&lt;/i&gt;.&lt;/b&gt; Immunization points are indicated by arrows. Mean an SD is presented (n = 8/group).&lt;/p&gt;
ECU-oriented models for NOx prediction. Part 2: adaptive estimation by using an NOx sensor (2014)

The implantation of nitrogen oxide sensors in diesel engines is necessary in order to track emissions at the engine exhaust line for diagnosis and control of the after-treatment devices. However, the use of models is still necessary since the sensor outputs are delayed and filtered. The present paper deals with the problem of the nitrogen oxide estimation in two parts; Part 1 deals with a control-oriented model for the nitrogen oxide estimation, while Part 2 presents data fusion of the model and the sensor to improve the estimation, which is presented in the following. The use of models for the nitrogen oxide estimation is an alternative but the drift and the ageing are still issues. In order to overcome this problem, the fusion of different signals can be carried out in a smart way by means of a Kalman filter. There exist different ways of presenting this fusion, from directly tracking the bias to updating the model parameters. For this, different algorithms are proposed in this paper with the aim of correcting the model output. Furthermore, the estimation of the actual nitrogen oxide concentration, by preventing sensor delay and filtering, is also integrated in the algorithm, which is a suitable strategy for combining nitrogen oxide sensors and models on an onboard basis.
A New Tool in the Toolbox: Electron-Withdrawing Group Activated Ruthenium Catalysts for Olefin Metathesis (2013)

This account describes the discovery and development of efficient electron-withdrawing group activated Hoveyda–Grubbs catalysts, including a nitro-substituted catalyst and their applications in the syntheses of complex molecules. 1 Introduction 2 EWG-Activated Hoveyda–Grubbs Complexes 2.1 The Discovery and the Story Behind It 2.2 The Nitro-Substituted Hoveyda–Grubbs Catalyst 2.3 pH-Responsive Catalysts 2.4 Fine-Tuning of the EWG Fragment 3 Applications of the Nitro-Substituted Hoveyda–Grubbs Catalyst in the Preparation of Compounds of Biological Relevance 3.1 Synthesis of BILN 2061 4 Concluding Remarks
Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γ (2007)

Conjunctival epithelial response to experimental dryness is related to the degree of CD4+ T-cell infiltration and the level of IFN-gamma production. These findings suggest that IFN-gamma plays a pivotal role in promoting conjunctival squamous metaplasia in dry eye, and they provide insight into the immune pathogenesis of keratoconjunctivitis sicca.
High Levels Of Interleukin-10 During The Initial Phase Of Fulminant Meningococcal Septic Shock (1995)

Interleukin (IL)-10 has an important antiinflammatory effect by inhibiting endotoxin-induced production of proinflammatory cytokines, such as tumor necrosis factor-alpha and IL-1. Since both cytokines are produced in massive amounts during fulminant meningococcal septic shock and are associated with severity of disease, IL-10 was measured in plasma samples of 25 consecutive children with fulminant meningococcal septic shock shortly after admittance to a pediatric intensive care unit. High levels of IL-10 (median, 6021 pg/mL; range, 137-24,600) were found in surviving patients (median, 1268 pg/mL; range, 137-24,600) and in those who died (median, 9915 pg/mL; range, 3996-14,100). IL-10 levels correlated weakly (r = .38; P = .055) with severity of disease as measured by the Glasgow meningococcal septicemia prognostic score. The findings indicate that IL-10 is produced in massive amounts in the initial phase of fulminant meningococcal septic shock.
A Facile Approach to Single‐Wall Carbon Nanotube/Poly(allylamine) Nanocomposites (2007)

Abstract A facile approach to polymer nanocomposites with single‐wall carbon nanotubes and cationic polymers is reported. The composite material was synthesized by producing carboxylic acid groups at the nanotube termini followed by a reaction with poly(allylamine) in water. Fourier transform infrared spectral and thermogravimetric analyses corroborate that the poly(allylamine) chains were wrapped on the surface of the carbon nanotubes. The scanning electron microscopic (SEM) image shows that the nanotubes were dispersed with little aggregation, thus, strongly suggesting that the poly(allylamine) chains have covered the single‐wall carbon nanotubes, which was further evidenced by transmission electron microscopy. The composites are soluble in water, and this solubilization process opens up new opportunities in the solution chemistry on pristine nanotubes. magnified image
High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in Arabidopsis. (2020)

Leaf senescence is a developmental process by which a plant actively remobilizes nutrients from aged and photosynthetically inefficient leaves to young growing ones by disassembling organelles and degrading macromolecules. Senescence is accelerated by age and environmental stresses such as prolonged darkness. Phytochrome B (phyB) inhibits leaf senescence by inhibiting phytochrome-interacting factor 4 (PIF4) and PIF5 in prolonged darkness. However, it remains unknown whether phyB mediates the temperature signal that regulates leaf senescence. We found the light-activated form of phyB (Pfr) remains active at least four days after a transfer to darkness at 20°C but is inactivated more rapidly at 28°C. This faster inactivation of Pfr further increases PIF4 protein levels at the higher ambient temperature. In addition, PIF4 mRNA levels rise faster after the transfer to darkness at high ambient temperature via a mechanism that depends on ELF3 but not phyB. Increased PIF4 protein then binds to the <i>ORE1</i> promoter and activates its expression together with ABA and ethylene signaling, accelerating leaf senescence at high ambient temperature. Our results support a role for the phy-PIF signaling module in integrating not only light signaling but also temperature signaling in the regulation of leaf senescence.
Gal4 protein binding is required but not sufficient for derepression and induction of GAL2 expression. (1993)

The Saccharomyces cerevisiae GAL2 gene upstream activator sequence (UAS) region was examined for protein bound in vivo by chromatin footprinting at high resolution. Gal4 transcriptional activator protein binds to the two consensus UAS sites whether GAL2 expression is induced, uninduced, or repressed by growth with different carbon sources. Although wild type strains show loss of the Gal4 protein-specific footprint in repressing media containing glucose, constitutive high level expression of Gal4 protein restores the GAL2 UAS footprints without fully derepressing GAL2 transcription. Thus binding of the Gal4 activator to target sites in the DNA is required but not sufficient for GAL2 derepression and induction. Gal4-independent protein-DNA complexes were also detected in the region, including one over the previously noted centromere-binding protein (CP1) site upstream of the Gal4 complexes.
Policing Temporality: Police Officers Reflect on the Role of the Police in Gentrifying a High-Crime Neighborhood (2022)

Prior research reveals the interrelations between gentrification and policing, yet this paper introduces the unheard perspective of the of police on their role in gentrification. The study focuses on South Tel Aviv, which houses immigrants, drug addicts, prostitution and houselessness. It is undergoing massive urban renewal and has become the most policed area in the city. Methodology includes interviews with police officers (N-15), ethnography with urban police and spatial analysis of urban renewal. The paper argues that: 1. Gentrifying a high-crime neighborhood triggers a collision of urban forces and spatial negotiations amid users, institutions, and areas in the city. 2. Police play a significant role in this process and must operate intensive borderwork on various scales, with technology becoming a tool for internal, microgeographical social borderwork. 3. Policing gentrification raises reflexivity among officers regarding their profession, social obligation and position in urban politics. The paper concludes with the concept of policing temporality to describe the role of police in gentrification.
The reaction of benzonorbornadiene and related compounds with iron carbonyls (1974)

Reaction of benzonorbornadiene, 7-isopropylidenebenzonorbornadiene (1,4-dihydro-9-isopropylidene-1,4-methanonaphthalene) and 1,4-dihydro-1,4-epoxynaphthalene (7-oxabenzonorbornadiene) with dicarbonyldinitrosyliron, Fe(CO)2(NO)2, gave in good yields the corresponding dimers having the exo-trans-exo configuration. Treatment of a mixture of benzonorbornadiene and norbornadiene with Fe(CO)2(NO)2 gave a 'crossed dimer', in addition to the dimers derived from benzonorbornadiene and norbornadiene. The reaction of benzonorbornadiene with pentacarbonyliron at 100º gave the exo-trans-exo dimer and a ketone derived by dimerization and carbonyl insertion. This ketone, and the analogous ketone obtained from 7-isopropylidenebenzonorbornadiene, have been assigned the exo-trans-exo configuration. Reaction of 1,4-dihydro-1,4-epoxynaphthalene with enneacarbonyldiiron, Fe2(CO)9, at room temperature gave tetracarbonyl(l,4-dihydro-l,4-epoxynaphthalene)iron(0), in which the olefinic ח-bond is bonded to the metal. In solution at 63º this complex gave naphthalene.
Paramagnetic Enediyne Antibiotic C-1027:  Spin Identification and Characterization of Radical Species (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTParamagnetic Enediyne Antibiotic C-1027: Spin Identification and Characterization of Radical SpeciesMasahiro Hirama, Kimio Akiyama, Toshiyuki Tanaka, Takeshi Noda, Kyo-ichiro Iida, Itaru Sato, Ryuji Hanaishi, Sumiko Fukuda-Ishisaka, Masaji Ishiguro, Toshio Otani, and John E. LeetView Author Information Department of Chemistry, Graduate School of Science Tohoku University, and CREST, Japan Science and Technology Corporation (JST), Sendai 980-8578, Japan Institute for Chemical Reactions, Tohoku University Sendai 980-8577, Japan, Center for Tsukuba Advanced Research Alliance, University of Tsukuba Tsukuba 305-8577, Japan, Suntory Institute for Bioorganic Research, Osaka 618-0024, Japan, Tokushima Research Center, Taiho Pharmaceutical Co. Ltd., Tokushima 771-0132, Japan, and Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492 Cite this: J. Am. Chem. Soc. 2000, 122, 4, 720–721Publication Date (Web):January 19, 2000Publication History Received8 September 1999Revised18 November 1999Published online19 January 2000Published inissue 1 February 2000https://pubs.acs.org/doi/10.1021/ja993256hhttps://doi.org/10.1021/ja993256hrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views341Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antimicrobial agents,Chromophores,Electron paramagnetic resonance spectroscopy,Equilibrium,Hydrogen abstraction Get e-Alerts
Biological activity of 24,24-difluoro-25-hydroxyvitamin D3. Effect of blocking of 24-hydroxylation on the functions of vitamin D. (1979)

To examine the question of whether 24-hydroxylation plays and importance role in the physiological functions of vitamin D, the biological activity of 24,24-difluoro-25-hydroxyvitamin D was compared with that of 25-hydroxyvitamin D in vitamin D-deficient rats. These two compounds were found almost identically active in the stimulation of intestinal calcium transport, the mobilization of calcium from bone, the healing of rachitic epiphyseal plate cartilage, the elevation of serum inorganic phosphorus, the mineralization of rachitic bone, and in the prevention of rachitogenesis in rats. Little or no difference was detected in the time course of response of intestinal calcium transport or bone calcium mobilization to the two forms of vitamin D. Therefore, in the rat no support could be obtained for the idea that 24,25-dihydroxyvitamin D3 plays an important role in the known physiological responses to the vitamin.
On some equilibria involving aluminium monohalides (1948)

P. Gross, C. S. Campbell, P. J. C. Kent and D. L. Levi, Discuss. Faraday Soc., 1948, 4, 206 DOI: 10.1039/DF9480400206
Towards the characterization of the genuine thermal and fire hazards of ionic liquids (2013)

As a novel class of solvents, ionic liquids have properties that make them promising key chemicals for the future bio-based economy. However, safety performance of ionic liquids relating physico-chemical hazards is very rarely investigated as they are often perceived as a non existing issue due to the status of ionic liquids in regulatory flammability hazard ranking systems. Limitations of conventional hazard rating in the case of ionic liquids lead to misleading statements pertaining physico-chemical hazards given the wide range of chemicals under interest (~10 18), while by contrast safety is of paramount importance as a goal in green chemistry principles. Thus, it becomes important to go beyond conventional hazard rating and therefore we promote the development of a dedicated methodology from hazard identification to contextual risk assessment, as illustrated in figure 1. For that purpose, work has been focused here to qualify fire hazard profiles of ionic liquids by use of both experimentation (oxygen bomb calorimetry, pyrolysis combustion flow calorimetry and fire propagation apparatus) and predictive tools using molecular modelling. The results of our study in particular provide: mutual support of these experimental methods, advanced pertinent knowledge on the actual fire hazards of ionic liquids, valuable data on heats and products released by such chemicals in fire conditions.
Branch-and-Bound Methods: A Survey (1966)

The essential features of the branch-and-bound approach to constrained optimization are described, and several specific applications are reviewed. These include integer linear programming (Land-Doig and Balas methods), nonlinear programming (minimization of nonconvex objective functions), the traveling-salesman problem (Eastman and Little, et al. methods), and the quadratic assignment problem (Gilmore and Lawler methods). Computational considerations, including trade-offs between length of computation and storage requirements, are discussed and a comparison with dynamic programming is made. Various applications outside the domain of mathematical programming are also mentioned.
LACIE—An Application of Meteorology for United States and Foreign Wheat Assessment (1980)

The development of a critical world food situation during the early 1970's was the background leading to the Large Area Crop Inventory Experiment (LACIE). The need was to develop a capability for timely monitoring of crops on a global scale. Three U.S. Government agencies, NASA, NOAA and USDA, undertook the task of developing technology to extract the crop-related information available from the global weather-reporting network and the Landsat satellite. This paper describes the overall LACIE technical approach to make a quasi-operational application of existing research results and the accomplishments of this cooperative experiment in utilizing the weather information. Using available agrometeorological data, techniques were implemented to estimate crop development, assess relative crop vigor and estimate yield for wheat, the crop of principal interest to the experiment. Global weather data were utilized in preparing timely yield estimates for selected areas of the U.S. Great Plains, the U.S.S.R. and Canada. Additionally, wheat yield models were developed and pilot tested for Brazil, Australia, India and Argentina. The results of the work show that heading dates for wheat in North America can be predicted with an average absolute error of about 5 days for winter wheat and 4 days for spring wheat. Independent tests of wheat yield models over a 10-year period for the U.S. Great Plains produced a root-mean-square error of 1.12 quintals per hectare (q ha−1) while similar tests in the U.S.S.R. produced an error of 1.31 q ha−1. Research designed to improve the initial capability is described as is the rationale for further evolution of a capability to monitor global climate and assess its impact on world food supplies.
Accurate Positioning System Based on Chipless Technology (2019)

In this paper, we present an accurate method to localize an object on a 2D plan using the chipless technology. This method requires a single antenna and a chipless tag. Phase difference between a reference position and an unknown position is used to estimate the distances between each resonator and the antenna. Then, multi-lateration is used to determine the position of the chipless tag in the plan. This method provides a better accuracy compared to classical ones based on received signal strength indicator (RSSI) or round-trip time-of-flight. In a square of 10 cm side above the antenna, error over distance determination between each resonators and the antenna is less than 2 mm and localization error on the tag coordinates in the 2D plan is lower than 1 cm. To increase the robustness of this method, we propose also a selection of a subset of the resonators used by the multi-lateration process. This method permits to increase the localization area by more than 20%. All the results have been obtained in real environment, and at different heights to show the robustness of the proposed approach. Finally, localization sensors based on this method can also be used as classical chipless RFID tag for identification with the same coding capacity.
Type I hereditary angio‐oedema. Variability of clinical presentation and course within two large kindreds (1997)

Hereditary angio-oedema is an autosomal dominant disease with great variability of clinical expression and severity, even within a single kindred. It often goes unrecognized over years, and it may lead to death if, in case of impending airway obstruction, specific therapy is not instituted.
CMOS‐based Thermal Sensors (2005)

This chapter contains sections titled: Introduction Thermal Radiation Sensors Thermal Converters Thermal Flow Sensors Acknowledgements References
Prediction of battery-SOC of pure electric vehicle (2012)

The accurate value of battery SOC is one of the prerequisites of a pure electric vehicle energy management to achieve optimal control. However, the battery is a highly nonlinear system and its charge-discharge process is difficult to establish accurate mathematical model. Taking into account nonlinear characteristics of BP neural network, and it has parallel structure and ability to learn, so it is suitable for online estimation of battery SOC value. Train BP neural network through Matlab programming, and predict the performance of the battery based on the built neural network model to get the battery SOC prediction. Simulation results show that the the established BP neural network has good adaptability, and is able to predict the mapping relationship between the battery voltage and SOC. This method is access to battery SOC prediction quickly and easily, the maximum error is less than 1% and the results meet the accuracy requirements.
An open label follow-up study on amisulpride in the add-on treatment of bipolar I patients. (2006)

This open-label study suggests that long-term therapy with amisulpride may benefit patients by improving global symptoms of bipolar disorder and reducing the rate of manic/mixed relapses. Large, randomized, double-blind, placebo-controlled studies are needed to explore the benefits of adding long-term amisulpride to standard therapies for bipolar disorder.