gebhart/patrepeval huggingface dataset:
rMELEISH:A Novel Recombinant Multiepitope-Based Protein Applied to The Serodiagnosis of Both Canine and Human Visceral Leishmaniasis (2022)

Background: Visceral leishmaniasis (VL) is s critical public health problem in over ninety countries. The control measures adopted in Brazil have been insufficient when it comes to preventing the spread of this neglected disease. In this context, a precise diagnosis of VL in dogs and humans could help to reduce the number of cases of this disease. Distinct studies for the diagnosis of VL have used single recombinant proteins in serological assays; however, results have been variable, mainly in the sensitivity of the antigens. The development of multiepitope-based proteins could be relevant in solving such a problem. Methods: A chimeric protein (rMELEISH) was constructed based on amino acid sequences from kinesin 39 (k39), alpha-tubulin, and heat shock proteins HSP70 and HSP 83.1, and tested in ELISA for the detection of L. infantum infection in humans and dogs. Results: rMELEISH was able to discriminate between VL cases and cross-reactive diseases and healthy samples, with sensitivity and specificity values of 100% as compared to the use of a soluble Leishmania antigenic extract (SLA). Conclusions: Preliminary data suggest that the rMELEISH protein presents a potential to be tested in future studies against a larger serological panel for the diagnosis of canine and human VL.
The utility of a 3-dimensional, large-field-of-view, sodium iodide crystal--based PET scanner in the presurgical evaluation of partial epilepsy. (2001)

For intractable partial epilepsy, FDG PET using a 3D, large-field-of-view, sodium iodide crystal-based scanner provided clinically useful localizing information that was at least as accurate as the results reported for traditional BGO-based scanners. The PET images provided prognostically significant localization information incremental to that provided by volumetric MRI and ictal EEG, particularly if 1 of these studies was nonlocalizing.
Niemann-Pick C1 Like 1 (NPC1L1) Is the Intestinal Phytosterol and Cholesterol Transporter and a Key Modulator of Whole-body Cholesterol Homeostasis (2004)

Niemann-Pick C1 Like 1 (NPC1L1) is a protein localized in jejunal enterocytes that is critical for intestinal cholesterol absorption. The uptake of intestinal phytosterols and cholesterol into absorptive enterocytes in the intestine is not fully defined on a molecular level, and the role of NPC1L1 in maintaining whole body cholesterol homeostasis is not known. NPC1L1 null mice had substantially reduced intestinal uptake of cholesterol and sitosterol, with dramatically reduced plasma phytosterol levels. The NPC1L1 null mice were completely resistant to diet-induced hypercholesterolemia, with plasma lipoprotein and hepatic cholesterol profiles similar to those of wild type mice treated with the cholesterol absorption inhibitor ezetimibe. Cholesterol/cholate feeding resulted in down-regulation of intestinal NPC1L1 mRNA expression in wild type mice. NPC1L1 deficiency resulted in up-regulation of intestinal hydroxymethylglutaryl-CoA synthase mRNA and an increase in intestinal cholesterol synthesis, down-regulation of ABCA1 mRNA, and no change in ABCG5 and ABCG8 mRNA expression. NPC1L1 is required for intestinal uptake of both cholesterol and phytosterols and plays a major role in cholesterol homeostasis. Thus, NPC1L1 may be a useful drug target for the treatment of hypercholesterolemia and sitosterolemia.
Monitoring Resuscitation of the Injured Patient (1977)

<h3>To the Editor.—</h3> The authors of "Monitoring Resuscitation of the Injured Patient" (237:242, 1977) have attempted to simplify a complex task, but in so doing have entirely neglected a basic principle of vascular physiology. As a result, they have made recommendations that are frankly dangerous. They state that mean pulmonary artery pressure (PAP) "is the best single means for assessing adequacy of restoration of fluid volume," and that "continued fluid administration in the presence of an elevated PAP is hazardous and could lead to development or aggravation of posttraumatic pulmonary insufficiency." The authors would have encountered little disagreement if these statements had been made about the pulmonary artery wedge pressure rather than the mean pulmonary artery pressure. It is the pulmonary artery wedge pressure that most accurately reflects (1) the adequacy of volume restoration to maintain left ventricular filling pressure, and (2) the pulmonary venous pressure— hence the tendency for
SPT + , the Next Generation of Low-Loss HV-IGBTs (2005)

Following the successful introduction of the high voltage Soft-Punch-Through (SPT) IGBT range, we introduce in this paper our next generation of HV-IGBTs employing the newly developed SPT + technology. The new IGBTs exhibit significant loss reduction in terms of on-state and turn-off losses while maintaining smooth switching waveforms and the extreme SOA performance characteristic of the well- established HV-SPT IGBTs.
Influence of signal rise time on the amount of forward masking. (1992)

Previously, a discrepancy between the amount of forward masking in the auditory nerve and published behavioral data was reported by these laboratories [E. M. Relkin and C. W. Turner, J. Acoust. Soc. Am. 84, 584–591 (1988)]; in that physiological experiment, however, a 2-ms signal rise time was employed, while the previous behavioral data used longer rise times. In the present behavioral study, both 2-ms and 10-ms signal rise-fall times were employed. The results show that for 10-ms ramps, the maximum amount of masking is large (at least 30 dB), in agreement with previous data. In contrast, for 2-ms ramps, the maximum amount of masking is smaller (15 dB). This is similar to the amount of masking in the auditory nerve reported in Relkin and Turner (1988), and indicates little or no discrepancy between behavioral and auditory nerve forward masking. This difference is observed for wide- and narrow-band maskers, suggesting that the results are not simply explained by the short-term spectra of the ramps. [Work supported by NINCDS.]
Design of multifunctional alarm platform (2013)

According to the living and production status,a multifunctional alarm platform was designed which can be used to detect temperature,dust,personnel and gas or other harmful gases.The platform could realize site alarm and emergency treatment,data display and remote SMS alarm.The experiments showed that the platform could be stable in operation,low in power consunption,simple in installation,and it is suitable for living and production safety area.
Pressure-driven flow of a vesicle through a square microchannel (2018)

The relative velocity and extra pressure drop of a single vesicle flowing through a square microchannel are quantified via boundary element simulations, lubrication theory and microfluidic experiments. The vesicle is modelled as a fluid sac enclosed by an inextensible, fluidic membrane with a negligible bending stiffness. All results are parametrized in terms of the vesicle sphericity (i.e. the reduced volume) and flow confinement (i.e. the ratio of the vesicle radius to the channel hydraulic radius). Direct comparison is made to previous studies of vesicle flow through circular tubes, revealing several distinct features of the square-channel geometry. Firstly, fluid in the suspending medium bypasses the vesicle through the corners of the channel, which in turn reduces the dissipation created by the vesicle. Secondly, the absence of rotational symmetry about the channel axis permits surface circulation in the membrane (tank treading), which in turn reduces the vesicle’s speed. At very high confinement, both theory and experiment indicate that the vesicle’s speed can be reduced below the mean speed of the suspending fluid through this mechanism. Finally, the contact area for lubrication is greatly reduced in the square-duct geometry, which in turn weakens the stress singularity predicted by lubrication theory. This fact directly leads to a breakdown of the lubrication approximation at low flow confinement, as verified by comparison to boundary element simulations. Since the only distinct property assumed of the membrane is its ability to preserve surface area locally, it is expected that the results of this study are applicable to other types of soft particles with immobilized surfaces (e.g. Pickering droplets, gel beads and biological cells).
Modeling multiphase migration of organic chemicals in groundwater systems--a review and assessment. (1989)

Over the past two decades, a number of models have been developed to describe the multiphase migration of organic chemicals in the subsurface. This paper presents the state-of-the-art with regard to such modeling efforts. The mathematical foundations of these models are explored and individual models are presented and discussed. Models are divided into three groups: a) those that assume a sharp interface between the migrating fluids; b) those that incorporate capillarity; and c) those that consider interphase transport of mass. Strengths and weaknesses of each approach are considered along with supporting data for model validation. Future research directions are also highlighted.
Shoulder Stiffness (2008)

Shoulder stiffness is commonly encountered in clinical practice but varies greatly in severity and etiology. Loss of shoulder range of motion can be a patient's primary complaint or may be a secondary finding. Possible causes of stiffness include guarding due to pain or secondary gain issues (nonanatomic), true mechanical blockage due to acute or chronic trauma, adhesive capsulitis, rotator cuff disease, or surgery on or near the shoulder. This review includes a more detailed discussion of these causes as well as the appropriate history and physical and diagnostic testing recommended for each. Finally, treatment strategies for each group of patients will be presented.
Role of Chest CT in the Follow-Up of Ovarian Adenocarcinoma (2001)

Correlation of the findings of abdominal and pelvic CT with the physical findings and the CA-125 levels serves as effective follow-up in patients with ovarian adenocarcinoma. The contribution of additional chest CT in these patients is small.
Robust classification of motor imagery EEG signals using statistical time–domain features (2013)

The tradeoff between computational complexity and speed, in addition to growing demands for real-time BMI (brain-machine interface) systems, expose the necessity of applying methods with least possible complexity. Willison amplitude (WAMP) and slope sign change (SSC) are two promising time-domain features only if the right threshold value is defined for them. To overcome the drawback of going through trial and error for the determination of a suitable threshold value, modified WAMP and modified SSC are proposed in this paper. Besides, a comprehensive assessment of statistical time-domain features in which their effectiveness is evaluated with a support vector machine (SVM) is presented. To ensure the accuracy of the results obtained by the SVM, the performance of each feature is reassessed with supervised fuzzy C-means. The general assessment shows that every subject had at least one of his performances near or greater than 80%. The obtained results prove that for BMI applications, in which a few errors can be tolerated, these combinations of feature-classifier are suitable. Moreover, features that could perform satisfactorily were selected for feature combination. Combinations of the selected features are evaluated with the SVM, and they could significantly improve the results, in some cases, up to full accuracy.
A Strategy for Comparing the Contributions of Environmental Chemicals and Other Risk Factors to Neurodevelopment of Children (2011)

A method for comparing the relative contributions of different risk factors provides a rational basis for establishing priorities for reducing neurodevelopmental morbidity in children.
Massive Access Management for QoS Guarantees in 3GPP Machine-to-Machine Communications (2011)

Realizing machine-to-machine (M2M) communications requires to construct and to manage scrupulous connections (logically and physically) from devices controllers to an enormous number of devices. By leveraging existing cellular infrastructures providing higher layers connections, the most challenging task is to efficiently manage massive accesses on the air interface. Consequently, in this letter, a massive access management (MAM) is proposed, which provides the most critical guarantees of quality-of-service (QoS), for devices. By deriving sufficient conditions of QoS guarantees, we show that the proposed MAM can effectively satisfy diverse QoS requirements, thus enabling the M2M communications over 3GPP scenarios.
Anthropometric and Performance Differences Among High-School Football Players (2010)

The purpose of this study was to examine physical and performance differences between grade levels and playing positions within High-School football players. Two thousand three hundred and twenty-seven athletes were tested for height, weight, 40-yd sprint time, proagility time, and vertical jump height. Mean scores across age groups and playing positions were compared using repeated-measures analysis of variance (ANOVA) and 1-way ANOVAs. The results indicate that defensive players in the 11th and 12th grades were significantly faster in the 40-yd sprint, quicker in the proagility, and generated more power than 9th and 10th grade defensive players across all positions (p < 0.05). Similarly, offensive players in the 11th and 12th grades were significantly faster, quicker, and jumped higher than did football players in lower grades (p < 0.05). Overall, these data suggest that there are distinct differences in the physical and performance characteristics of high-school football players. The greatest difference is observed between the sophomore and junior years. Older, more mature athletes are faster, quicker, and capable of generating more power than younger athletes. Practically, these data lend support to the common 3-tiered approach (i.e., Freshman, Junior Varsity, and Varsity) most high schools use for their football programs. This approach is likely indicated to allow for physical maturation of young players and to allow time for the development of strength, power, speed, and agility necessary to compete with older players.
Introduction to ACS Catalysis Virtual Special Issue on Cascade Catalysis (2014)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTIntroduction to ACS Catalysis Virtual Special Issue on Cascade CatalysisWolfgang Kroutil and Magnus RuepingView Author Information Department of Chemistry, University of Graz Institute of Organic Chemistry, RWTH Aachen UniversityCite this: ACS Catal. 2014, 4, 6, 2086–2087Publication Date (Web):May 28, 2014Publication History Published online28 May 2014Published inissue 6 June 2014https://doi.org/10.1021/cs500622hCopyright © 2014 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2504Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (579 KB) Get e-AlertsSUBJECTS:Biocatalysis,Catalysis,Catalysts,Chemical reactions,Peptides and proteins Get e-Alerts
Dragonfly algorithm for Solving Flexible Jobshop Scheduling Problem (2020)

Industrial scheduling problem has always been one of key problems in manufacturing and management planning enterprises. Flexible job shop scheduling problem is one of most difficult scheduling problems, which is also a classical NP hard problem. Compared to the JSP, each process in the FJSP should be processed on each available machine to minimize the total processing time. For this reason, it is far more complex than the classic JSP. In this paper, a recent proposed swarm intelligence algorithm named dragonfly algorithm (DA) is adopted to solve the FJSP. Some traditional algorithms are also used to evaluate the performance on several famous FJSP benchmark compared with DA. Numerical results show that DA has stronger global searching ability and can achieve better results in solving FJSP than other algorithms.
Fracture Analysis of Full-Thickness Clad Beam Specimens (1997)

Finite-element analyses were performed on full-thickness clad beam specimens to quantify fracture toughness for shallow cracks in material for which metallurgical conditions are prototypic of those found in reactor pressure vessels (RPVs). The beam specimens are fabricated from a section of an RPV wall (removed from a canceled nuclear plant) that includes weld, plate, and clad material with metallurgical factors potentially influencing fracture toughness for shallow cracks. A summary of the testing program is provided and the analyses of the test data are discussed, including comparisons of measured displacements with finite-element analysis results, applications of toughness estimation techniques, and interpretations of constraint conditions implied by stress-based constraint methodologies. Fracture toughness estimates were obtained from displacement data using finite-element techniques and estimation schemes based on the η-factor method. The J-Q methodology was used to assess crack-tip stress triaxiality in the clad beam specimens. The shallow-crack clad beam specimens showed a significant loss of constraint similar to that of other shallow-crack single-edge notch bend specimens. The stress-based Dodds-Anderson scaling model was also utilized to analyze constraint conditions in the clad beam specimens and appears to be effective in adjusting the test data to account for loss of in-plane constraint for uniaxially tested beams.
Singlet nuclear magnetic resonance of nearly-equivalent spins (2011)

Nuclear singlet states may display lifetimes that are an order of magnitude greater than conventional relaxation times. Existing methods for accessing these long-lived states require a resolved chemical shift difference between the nuclei involved. Here, we demonstrate a new method for accessing singlet states that works even when the nuclei are almost magnetically equivalent, such that the chemical shift difference is unresolved. The method involves trains of 180° pulses that are synchronized with the spin-spin coupling between the nuclei. We demonstrate experiments on the terminal glycine resonances of the tripeptide alanylglycylglycine (AGG) in aqueous solution, showing that the nuclear singlet order of this system is long-lived even when no resonant locking field is applied. Variation of the pulse sequence parameters allows the estimation of small chemical shift differences that are normally obscured by larger J-couplings.
The cost of managing impressions for Black employees: An expectancy violation theory perspective. (2022)

This study identifies a unique bias faced by Black employees which makes it challenging for this group to manage their professional image. Integrating research on racial backlash, image management, and expectancy violation theory, we argue that self-promotion by Black employees will result in detrimental outcomes for this group compared to White, Hispanic, and Asian employees. Due to negative racial stereotypes related to their job competence, we hypothesize that self-promotion by Black employees will be viewed by their White managers as a violation of stereotypically appropriate behavior and will result in a backlash in the form of lower job-related outcomes. We propose that the process by which these effects occur is through manager assessments of their employees on agentic and communal traits. Our hypothesized model was tested with a stratified sample of manager-employee dyads of a large financial institution. Results indicated that self-promotion by Black employees was associated with lower job performance and person-organization fit ratings, as well as fewer idiosyncratic deals with their immediate managers compared to White, Hispanic, and Asian employees. Implications of the divergent consequences of self-promotion for Black employees relative to other racial groups are discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Targeted Disruption of a Murine Glucuronyl C5-epimerase Gene Results in Heparan Sulfate Lacking l-Iduronic Acid and in Neonatal Lethality (2003)

The glycosaminoglycan, heparan sulfate (HS), binds proteins to modulate signaling events in embryogenesis. All identified protein-binding HS epitopes contain l-iduronic acid (IdoA). We report that targeted disruption of the murine d-glucuronyl C5-epimerase gene results in a structurally altered HS lacking IdoA. The corresponding phenotype is lethal, with renal agenesis, lung defects, and skeletal malformations. Unexpectedly, major organ systems, including the brain, liver, gastrointestinal tract, skin, and heart, appeared normal. We find that IdoA units are essential for normal kidney, lung, and skeletal development, albeit with different requirement for 2-O-sulfation. By contrast, major early developmental events known to critically depend on heparan sulfate apparently proceed normally even in the absence of IdoA.
Fuel performance models for high-temperature gas-cooled reactor core design (1983)

Mechanistic fuel performance models are used in high-temperature gas-cooled reactor core design and licensing to predict failure and fission product release. Fuel particles manufactured with defective or missing SiC, IPyC, or fuel dispersion in the buffer fail at a level of less than 5 x 10/sup -4/ fraction. These failed particles primarily release metallic fission products because the OPyC remains intact on 90% of the particles and retains gaseous isotopes. The predicted failure of particles using performance models appears to be conservative relative to operating reactor experience.
Polarimetric Remote Sensing of Sea Ice in the Beaufort Sea (2005)

Data were collected in March 1988 with the Jet Propulsion Laboratory (JPL) polarimetric airborne synthetic aperture radar (SAR). Full covariance matrices were obtained from the scattering data with proper consideration of the polarimetric calibration. Images were processed to form the sea ice scenes in the Beaufort sea. These scenes contain various ice types including thin ice, thick first-year ice, and multiyear ice. Sea ice was modeled as a layer random medium and the polarimetric backscattering coefficients were calculated under the distorted Born approximation with effective permittivities obtained from the strong fluctuation theory. Sea ice signatures remotely observed by the JPL SAR over the Beaufort sea ice scenes were interpreted by comparing their behavior at different incident angles with results obtained from the theoretical model.