gebhart/patrepeval huggingface dataset:
Abstract 362: Dysregulation of CPT2 Splicing in Diabetic Heart Disease (2014)

Diabetes mellitus is a group of metabolic diseases that are caused by elevated blood glucose levels. Individuals with diabetes have an increased risk of cardiovascular complications that include diabetic cardiomyopathy, hypertension, and coronary artery disease. Research has shown that hyperglycemia causes metabolic abnormalities in the heart such that cardiomyocytes are unable to utilize glucose for energy production due to reduced glucose intake, instead they solely depend on fatty acid oxidation for energy. Eventually, fatty acids accumulate and cause cardiac lipotoxicity, a presumed factor in the development of diabetic cardiomyopathy. Carnitine Pamitoyl Transferease 2 (CPT2) is one of the enzymes responsible for the transport of long-chain fatty acids into the mitochondria for fatty acid oxidation and energy production. CPT2 activity is elevated in diabetic hearts by mechanisms that are unclear. CPT2 is composed of 5 exons; the largest, exon 4 contains the transferase domain and is alternatively spliced in diabetes. In normal hearts, half of the CPT2 transcripts include exon 4 representing the active form of the enzyme. Through RNA sequencing analysis assay, we discovered that CPT2 is mis-spliced in diabetic hearts in a way that 70% of total CPT2 transcripts include the functional domain exon 4. The splicing change in CPT2 results in increased expression of the active CPT2 isoform in diabetic hearts. In summary, we identified a functionally important alternative splicing event in the CPT2 gene that may contribute to increased fatty acid oxidation and lipotoxicity in the diabetic heart.
Sputtering of very thin palladium-alloy hydrogen separation membranes (2005)

This feature describes a unique method of manufacturing hydrogen separation membranes. It involves creating a palladium–silver layer on a substrate with a polished surface, then removing and transferring it to a membrane support. This novel technique produces highly selective thin layers with a high hydrogen flux, making their use for hydrogen separation economically attractive.
Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network (2016)

Motor neurons of the crustacean cardiac ganglion generate virtually identical, synchronized output despite the fact that each neuron uses distinct conductance magnitudes. As a result of this variability, manipulations that target ionic conductances have distinct effects on neurons within the same ganglion, disrupting synchronized motor neuron output that is necessary for proper cardiac function. We hypothesized that robustness in network output is accomplished via plasticity that counters such destabilizing influences. By blocking high-threshold K(+) conductances in motor neurons within the ongoing cardiac network, we discovered that compensation both resynchronized the network and helped restore excitability. Using model findings to guide experimentation, we determined that compensatory increases of both GA and electrical coupling restored function in the network. This is one of the first direct demonstrations of the physiological regulation of coupling conductance in a compensatory context, and of synergistic plasticity across cell- and network-level mechanisms in the restoration of output.
Mutremdamide A and Koshikamides C−H, Peptide Inhibitors of HIV-1 Entry from Different Theonella Species (2010)

A new sulfated cyclic depsipeptide, termed mutremdamide A, and six new highly N-methylated peptides, termed koshikamides C-H, were isolated from different deep-water specimens of Theonella swinhoei and Theonella cupola. Their structures were determined using extensive 2D NMR, ESI, or CDESI and QTOF-MS/MS experiments and absolute configurations established by quantum mechanical calculations, advanced Marfey's method, and chiral HPLC. Mutremdamide A displays a rare 2-amino-3-(2-hydroxyphenyl)propanoic acid and a new N(delta)-carbamoyl-beta-sulfated asparagine. Koshikamides C-E are linear undecapeptides, and koshikamides F-H are 17-residue depsipeptides containing a 10-residue macrolactone. Koshikamides F and G differ from B and H in part by the presence of the conjugated unit 2-(3-amino-5-oxopyrrolidin-2-ylidene)propanoic acid. Cyclic koshikamides F and H inhibited HIV-1 entry at low micromolar concentrations while their linear counterparts were inactive. The Theonella collections studied here are distinguished by co-occurrence of mutremdamide A, koshikamides, and theonellamides, the combination of which appears to define a new Theonella chemotype that can be found in deeper waters.
Challenges in Meeting the Framework for SHM System Certification and Compliance (2017)

Monitoring the continued health of aircraft subsystems and identifying problems before they affect airworthiness has been a long-term goal of the aviation industry. Towards this end, Structural Health Monitoring (SHM) systems that could be used for the in-service monitoring of the health of new and existing aircraft structures are being matured. This paper will go step-by-step into the various challenges associated with meeting preliminary certification compliance requirements. A 5-year program completed under funding from the Federal Aviation Administration will be used as a guide to lead the reader through the various certification compliance steps The objectives of this program were to (1) develop, validate, and demonstrate Smart Patch System (SPS) technologies including advanced software, algorithms, and methodologies for structures and dynamic components to (a) detect fatigue cracks and damages before exceeding critical threshold or incipient failure and (b) characterize fatigue cracks and damages, and (2) develop preliminary certification compliance requirements and a framework for certification of an SPS that would be integrated into a Health and Usage Monitoring System (HUMS) for the fatigue crack monitoring of commercial rotorcraft structures per the guidelines provided in FAA Advisory Circular AC 29-2C, Section MG-15. This paper will use this program as a guide to discuss certification compliance challenges and recent work done to meet them. It presents the details on the tasks that were conducted towards the development, validation, and potential certification of the SPS and other similar SHM systems for specific structural applications.
Design of a protocol to enable economic transactions for network services (2015)

Deployment of innovative new networking services requires support by network providers. Since economic motivation plays an important role for network providers, it is critical that a network architecture intrinsically considers economic relationships. We present the design of a protocol that associates access to network services with economic contracts. We show how this protocol can be realized in fundamentally different ways, using out-of-band signaling and in-band signaling, based on two different prototype implementations. We present results that show the effectiveness of the proposed protocol and thus demonstrate a first step toward realizing an economy plane for the Internet.
Rate of Inclusion Removal from Molten Metal to Slag with Injecting Gas from Multi-orifice and Multi-nozzle (1995)

Studies have been made on bubble formation at non-wetted nozzles and orifices and on the effect of bubble size on the rate of inclusion removal from molten metal.The bubble formation at a nozzle or an orifice in mercury has been investigated. The experimental values of size of the bubble formed at a nozzle agree with those calculated from correlating equations using outer diameter of the nozzle. In the case of lower gas flow rate, the bubble size increases with increasing outer diameter of the nozzle (dno<7mm). At nozzle diameter of dno>7mm, the bubble size is independent of dno, and the nozzle can be regarded as an orifice. The bubble size increases with increasing gas-chamber volume under the conditions where the gas flow rate is relatively low and the dimensionless gas-chamber volume, Nc', is larger than unity.The rate of SiO2 inclusion removal from molten Cu to slag with injecting Ar gas from multi-orifice and multi-nozzle has been examined. In the case of multi-orifice, the bubble size increases with increasing the number of orifices. This shows that the growing bubbles coalesce into one on the surface of the orifice plate. The rate of inclusion removal decreases with increasing bubble diameter. It is confirmed that the inclusion particles are removed from the melt mainly through adhesion to the bubble-metal interface.
Conduction in Polyimide Films before Breakdown using Fast Infrared Thermography (2015)

International audience
Propulsion for Agile Landmines II, Dynamic Simulations and Experiments (2002)

A desire to eliminate Anti-Personnel Landmines (APL’s) led to the development of a Self Healing MineField (SHMF) concept using mobile Anti-Tank Landmines (ATL’s). Investigations were conducted to determine the viability of using small solid rocket motors and thrust vector rotation during launch to propel agile landmines to desired heights and ranges and experimentally determine the influence of rotational velocity, surface type and inclined surfaces on roll distance after impact. Dynamic simulations of the trajectory were produced and the data was used to conduct preliminary parametric studies. The effect of the ground plane interaction during ignition was analyzed along with the effect of varying ground slope on the trajectory. A model of the mine was designed and fabricated to match the mass and moment of inertia properties of one of the agile landmine concept designs. A test rig was developed and fabricated to obtain the desired initial impact range (and altitude) calculated from the simulations. The data &om the trajectory experiments were used to conduct statistical analysis on the roll distance after impact.
Natural language question answering: the view from here (2001)

As users struggle to navigate the wealth of on-line information now available, the need for automated question answering systems becomes more urgent. We need systems that allow a user to ask a question in everyday language and receive an answer quickly and succinctly, with sufficient context to validate the answer. Current search engines can return ranked lists of documents, but they do not deliver answers to the user. Question answering systems address this problem. Recent successes have been reported in a series of question-answering evaluations that started in 1999 as part of the Text Retrieval Conference (TREC). The best systems are now able to answer more than two thirds of factual questions in this evaluation.
Quantum dots embedded into silicon nanowires effectively partition electron confinement (2008)

Motivated by the experimental discovery of branched silicon nanowires, we performed theoretical electronic structure calculations of icosahedral silicon quantum dots embedded into pentagonal silicon nanowires. Using the semiempirical method, we studied the quantum confinement effect in the fully optimized embedded structures. It was found that (a) the band gaps of the embedded structures are closely related to the linear sizes of the longest constituting part rather than to the total linear dimension and (b) the discovered atypical quantum confinement with a plateau and a maximum can be attributed to the substantial interactions of near Fermi level electronic states of the quantum dots and nanowire segments.
The standards are coming! Standards for security in object-oriented systems (1994)

article Free Access Share on The standards are coming! Standards for security in object-oriented systems Authors: William R. Herndon The MITRE Corporation, 7525 Colshire Drive, McLean, VA The MITRE Corporation, 7525 Colshire Drive, McLean, VAView Profile , Ravi Sandhu ISSE Department, George Mason University, Fairfax, VA ISSE Department, George Mason University, Fairfax, VAView Profile , Steve Demurjian Computer Science and Engineering Dept., University of Connecticut, Box U-155, 260 Glenbrook Rd., Storrs, CT Computer Science and Engineering Dept., University of Connecticut, Box U-155, 260 Glenbrook Rd., Storrs, CTView Profile Authors Info & Claims ACM SIGPLAN OOPS MessengerVolume 5Issue 4Oct. 1994 pp 92–95https://doi.org/10.1145/260060.260131Online:01 October 1994Publication History 0citation202DownloadsMetricsTotal Citations0Total Downloads202Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
SiOx patterned based substrates implemented in Cu(In, Ga)Se2 ultrathin solar cells: optimum thickness (2021)

Interface recombination in sub-µm optoelectronic devices has a major harmful impact in devices performance, showing the need for tailored passivation strategies in order to reach a technological boost. In this work, SiOx based substrates were developed and integrated in ultrathin CIGS solar cells. This study aims at understanding the impact of several SiOx layer thicknesses (3, 8 and 25 nm) when this material is used as a passivation layer. Analysing their electrical parameters, the 8 nm novel SiOx based substrates achieved light to power conversion efficiency values up to 13.2%, a 1.3% absolute improvement over the conventional substrate (without SiOx).
Preemptive Craniectomy With Craniotomy: What Role in the Management of Severe Traumatic Brain Injury? (2009)

CE was used in patients with more severe injuries, and particularly in those with more severe head injuries. When adjusted for injury severity, CE was not associated with worsened survival, and therefore may reasonably be included in the armamentarium of neurotrauma care. Use of CE by our neurosurgeons, however, varied significantly. These findings underscore the need for practice guidelines based on randomized trials to fully evaluate the role of CE in the management of TBI.
HPLC determination of the related substances in carbocisteine and its preparation (2006)

Objective:To establish an HPLC method for assay the related substances in carbocisteine and its prepa- ration.Methods:A Diamonsil C_18(4.6mm×150mm,5μm)column was used.The mobile phase was:Add 6.8 g potassium dihydrogen phosphate,and 0.5 g sodium heptanesulfonate to 1000 mL water(adjust its pH value to 2.5 by phosphoric acid).The detective wavelength was 215 nm,the flow rate was 1.0 mL·min~(-1),the column tempera- ture was 35℃,and the injection volume was 20 μL.Results:The major peak′s theoretical plate number was 5964, the resolution was 3.0,the lowest limit of detection was 12.6 ng.Conclusion:The method is sensitive,simple and accurate,and can be used for the determination of impurities and degradation products.
Approximate inference for infinite contingent Bayesian networks (2005)

In many practical problems---from tracking aircraft based on radar data to building a bibliographic database based on citation lists---we want to reason about an unbounded number of unseen objects with unknown relations among them. Bayesian networks, which define a fixed dependency structure on a finite set of variables, are not the ideal representation language for this task. This paper introduces contingent Bayesian networks (CBNs), which represent uncertainty about dependencies by labeling each edge with a condition under which it is active. A CBN may contain cycles and have infinitely many variables.
Oxidative dimerization of anilines with heterogeneous sulfonic acid catalysts (2017)

Sulfonic acids selectively catalyze the oxidative dimerization of anilines to azobenzenes without any unnecessary organics.
<title>Holographic diffusers for LCD cockpit displays</title> (1994)

We have developed holographic diffusers that provide achromatic forward scattering with low backscatter and absorption, even at large scattering angles. The angular scattering pattern may be highly asymmetric in the azimuth and elevation directions, and may also be skewed away from the incident beam. Volume phase holographic diffusers recorded in dichromated gelatin exhibit particularly low backscatter and absorption, and also exhibit the unique property that the output lobe in some configurations does not move with the input ray angle. These diffuser properties allow the fabrication of efficient, uniform backlights for LCD displays in aircraft cockpits.
Etude de la flore bactérienne dans les plaies tumorales du sein : incidence des biofilms bactériens sur l'évolution des plaies et le développement d'odeurs (2012)

The malignant wound is an infiltration by tumoral cells of the cutaneous tissue, the blood and/or lymphatic vessels. These wounds can appear in different forms and and be accompagnied by various symptoms. Independently of the septic risk, the presence of nauseating odors induces social, family and conjugal difficulties, expressed mostly by disgust, a sensation of dirt or decay. It influences the medical behavior.Bacterial colonisation, odors and septic risks seem to be connected and mainly occur in patients who have a chronic wound and are immunodepressed by the anticancer therapies. This projetc [was] consisted in: 1) create a case report form and sample the malignant wound (clinical research), 2) characterize the microbial flora, the biofilm, and the volatile compounds with an experimental and collaborative approach, 3) analyse the results and the potential correlation between [the] laboratory's results and the clinical aspect of the wound, 4), propose potential solutions, hypothetis, and improvements of the clinical practice.A mixed flora, composed of 54 different bacterial types was identified; a biofilm was caracterized in 35% of cases. 91 volatile compounds were identified. No infection occurred during the evaluation period. The consequences of the interactivity of the bacteria, the biofilm and the volatils compounds suggest to: 1) develop new strategies and topics, 2) continue the research on the biofilm, 3) propose a research program with psycho-oncologists and neuropsychiatrics, 4) progress toward diagnostic tests conception and biomarkers identification.
Two-dimensional multiple quantum N.M.R. of isotopic mixtures in liquid crystals (1987)

A technique is presented for the experimental determination and assignment of dipolar coupling constants from the N.M.R. spectra of molecules dissolved in liquid crystals. The technique is applicable to larger molecules than have been studied to date. Random deuteration of the molecule results in a statistical mixture of partially protonated species which can be analysed by two-dimensional and multiple quantum N.M.R. techniques to determine and assign all the dipole coupling constants. Benzene is used as an illustrative example.
Simulations géostatistique de modèles de réservoir à maille irrégulière utilisant des méthodes non-linéaires de la géostatistique (2015)

International audience
Self-assembling peptide amphiphiles and related methods for growth factor delivery (2017)

Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related methods of use.
Fluorinated pharmaceuticals: advances in medicinal chemistry: introductory remarks (2015)

Following his move to Cardiff he has established a number of collaborative research projects focusing on breast cancer drug discovery, new synthetic chemistry methods
Partially correlated source decomposition techniques from a beamforming analysis (2016)

Recent improvements have extended the capabilities of beamforming methods from the uncorrelated monopole assumption to enable reconstructions of extended, partially correlated sources. Resulting source information contains both level and coherence properties that can predict the radiated sound field. In addition, the source cross-spectral matrix, while accurate, can in many cases be reduced into a more convenient or physically meaningful set of basis vectors. For example, a wavepacket is a self-coherent distribution that may be used to create a minimal set of mutually orthogonal basis vectors representing the source levels and coherence properties. In this study, a complex, extended, and partially correlated source is modeled, and the simulated near-field measurements are analyzed with inverse techniques (i.e., beamforming). Possible decompositions are evaluated for their ability to accurately represent the source properties, as well as reliably predict the field levels and coherence properties using the fewest basis terms. Decompositions examined include proper-orthogonal decomposition and spatial decomposition based on coherence lengths. The results point towards an improved interpretation of the source reconstructions and methods for predicting the noise environment from an extended, partially correlated noise source. [Work supported by ONR and USAFRL through ORISE.]
Analysis of Smartphone User Behavior (2010)

Holistic, objective and precise data on mobile user behavior and experience are needed in today's product development and marketing activities. This article presents a framework for mobile audience measurements, for collecting data at the point of convergence - devices. The paper compares the presented framework to alternative methods of mobile user research, and identifies the unique advantages of on-device measurements along with the key weaknesses. In addition to elaborating on data collection, the paper addresses the related analytics, presenting adoption modeling and stickiness analysis that complement the data collection processes and deliver practical insights. The insights can be provided to device vendors, application developers and carriers, who can use the insights in product portfolio management, product development, and marketing.
The healthy worker effect in US chemical industry workers (2010)

The low SMRs observed in this study are likely due to differential smoking between the cohort and the background population. Future considerations to control for the HWE should take this into account.
Evaluation, degradation and life assessment of coatings for land based combustion turbines (2006)

Use of metallic and thermal barrier coatings to protect hot section blades and vanes of combustion turbines for power generation has been common practice for the past three and one decades respectively. Because these coatings must be optimised with respect to both different forms of corrosion and modes of operation (base load versus peak load), their performance may be machine specific. Industrial end users generally do not have detailed knowledge of the failure mechanisms of the coatings and the basis for selecting coatings to suit specific requirements, topics the present review seeks to address. The evolution of protective coatings, coating failure mechanisms and a methodology for selecting machine specific coatings are described. The methodology, which can be used to rank and optimise coating systems and to predict the remaining life of coatings, forms the basis of a computer code known as COATLIFE. The ingredients of this methodology, i.e. degradation modelling and thermomechanical fatigue life prediction, are reviewed.
High aspect ratio composite structures with 48.5% thermal neutron detection efficiency (2013)

The pillar structured thermal neutron detector is based on the combination of high aspect ratio silicon p-i-n pillars surrounded by the neutron converter material 10B. By etching high aspect ratio pillar structures into silicon, the result is a device that efficiently absorbs the thermal neutron flux by accommodating a large volume fraction of 10B within the silicon pillar array. Here, we report a thermal neutron detection efficiency of 48.5% using a 50 μm pillar array with an aspect ratio of 25:1.