gebhart/patrepeval huggingface dataset:
The HLA Complex and the Pathogenesis of Infectious Diseases (1985)

Journal Article The HLA Complex and the Pathogenesis of Infectious Diseases Get access Marilyn S. Pollack, Marilyn S. Pollack Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert R. Rich Robert R. Rich Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 151, Issue 1, January 1985, Pages 1–8, https://doi.org/10.1093/infdis/151.1.1 Published: 01 January 1985
Water Vapor Sorption and Diffusivity in Bio-Based Poly(ethylene vanillate)—PEV (2021)

The dynamic and equilibrium water vapor sorption properties of amorphous and highly crystalline poly(ethylene vanillate) (PEV) films were determined via gravimetric analysis, at 20 °C, over a wide range of relative humidity (0-95% RH). At low RH%, the dynamic of the sorption process obeys Fick's law while at higher relative humidity it is characterized by a drift ascribable to non-Fickian relaxations. The non-Fickian relaxations, which are responsible for the incorporation of additional water, are correlated with the upturn of the sorption isotherms and simultaneously the hysteresis recorded between sorption and desorption cycles. The sorption isotherms of amorphous and highly crystalline PEV are arranged in the same concentration range of that of PET proving the similarity of the two polyesters. Water diffusion coefficients, whose determination from individual kinetic sorption/desorption curves required treatment with the Barens-Hopfenberg model, were demonstrated to be ≈ 10× higher for amorphous PEV compared to amorphous PET. Such a difference originates from the enhanced segmental flexibility of PEV chains.
Experimental Determination of Moments of Inertia by the Bifilar Pendulum Method (1970)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation John W. Then, Kang-rong Chiang; Experimental Determination of Moments of Inertia by the Bifilar Pendulum Method. Am. J. Phys. 1 April 1970; 38 (4): 537–539. https://doi.org/10.1119/1.1976385 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersAmerican Journal of Physics Search Advanced Search |Citation Search
High‐resolution sequence typing of HLA‐DQA1 and ‐DQB1 exon 2 DNA with taxonomy‐based sequence analysis (TBSA) allele assignment (1999)

High-resolution DNA sequencing of exon 2 of DQA1 and DQB1 genes that uses a taxonomy-based sequence analysis (TBSA) method to assign alleles was developed. The system uses fewer primers for polymerase chain reaction (PCR) amplification and sequencing than other methods and yields accurate DQA1 and DQB1 typing when either homozygous or heterozygous DNA samples are tested. The approach was initially corroborated by the correct typing of 10 blinded samples that had been previously typed by PCR using sequence-specific oligonucleotide probes (PCR-SSOP) or serology, and subsequently confirmed by sequencing of cloned PCR products. DNA from peripheral blood cell samples of 130 individuals enrolled in a case-control analysis of HLA determinants of abdominal aortic aneurysm were subsequently evaluated. Overall, 8 different DQA1 and 19 DQB1 alleles were identified. All 21 DQA1 heterozygous combinations and 45 of 49 DQB1 heterozygous combinations were successfully resolved with TBSA. The two pairs of heterozygous DQB1 combinations that were not unambiguously typed required sequence specific PCR amplification for correct allele identification. We conclude that the method provides precise analysis for HLA-DQ typing.
A Two-Dimensional Spectrum for Bistatic SAR Processing Using Series Reversion (2007)

This letter derives the two-dimensional point target spectrum for an arbitrary bistatic synthetic aperture radar configuration. The method described makes use of series reversion, the method of stationary phase, and Fourier transform pairs to derive the point target spectrum. The accuracy of the spectrum is controlled by keeping enough terms in the two series expansions, and is verified with a point target simulation
Pineal Hyperactivity in Spontaneously Hypertensive Rats: Muscarinic Regulation of Indole Metabolism (1990)

1. Choline acetyltransferase activity and [3H]quinuclidinyl benzylate-binding sites were detected in the pineal gland of normotensive Wistar-Kyoto rats and of spontaneously hypertensive rats. 2. In vitro, muscarinic activation by pilocarpine increased the pineal metabolic production of hydroxyindole derivatives up to 5-hydroxytryptamine and produced a less marked stimulation of melatonin biosynthesis. 3. Electrical field stimulation of pineal gland slices caused similar metabolic effects. 4. Muscarinic blockade with atropine inhibited the effects on hydroxyindole metabolism. 5. [3H]Quinuclidinyl benzylate-binding sites, indicative of muscarinic receptors, were more numerous, and basal 5-hydroxytryptamine and melatonin levels were higher, in the pineal gland of spontaneously hypertensive rats compared with Wistar-Kyoto rats. 6. The atropine-sensitive metabolic effects of pilocarpine and electrical field stimulation on the pineal gland were increased in spontaneously hypertensive rats compared with Wistar-Kyoto rats.
Purification of Ag-Specific T Lymphocytes After Direct Peripheral Blood Mononuclear Cell Stimulation Followed by CD25 Selection. I. Application to CD4+ or CD8+ Cytomegalovirus Phosphoprotein pp65 Epitope Determination (2001)

The two main constraints that currently limit a broader usage of T cell therapy against viruses are the delay required to obtain specific T cells and the safety of the selection procedure. In the present work we developed a generally applicable strategy that eliminates the need for APC for timing reasons, and the need for infectious viral strains for safety concerns. As a model, we used the selection of T lymphocytes specific for the immunodominant CMV phosphoprotein pp65. PBMC from healthy seropositive donors were first depleted of IL-2R alpha-chain CD25(+) cells and were then stimulated for 24-96 h with previously defined peptide Ags or with autologous PBMC infected with a canarypox viral vector encoding the total pp65 protein (ALVAC-pp65). Subsequent immunomagnetic purification of newly CD25-expressing cells allowed efficient recovery of T lymphocytes specific for the initial stimuli, i.e., for the already known immunodominant epitope corresponding to the peptides used as a model or for newly defined epitopes corresponding to peptides encoded by the transfected pp65 protein. Importantly, we demonstrated that direct PBMC stimulation allowed recovery not only of CD8(+) memory T lymphocytes, but also of the CD4(+) memory T cells, which are known to be crucial to ensure persistence of adoptively transferred immune memory. Finally, our analysis of pp65-specific T cells led to the identification of several new helper and cytotoxic epitopes. This work thus demonstrates the feasibility of isolating memory T lymphocytes specific for a clinically relevant protein without the need to prepare APC, to use infectious viral strains, or to identify immunodominant epitopes.
Biotechnology in Flavor Production (2016)

1. The development of yeast strains as tools to adjust the flavor of fermented beverages to market specifications (Jan H. Swiegers, Sofie M.G. Saerens and Professor Isak S. Pretorius, The Australian Wine Research Institute, Glen Osmond, Adelaide, Australia). 2. Biotechnology of flavor production in dairy products (Dr Bart C. Weimer, Sweta Rajan, Bala Ganesan, Center for Integrated BioSystems, Department of Nutrition and Food Sciences, Utah State University, Logan, Utah, USA). 3. Biotechnological production of vanillin (Dr Daphna Havkin-Frenkel and Dr Faith C. Belanger, The Biotechnology Center for Agriculture & the Environment, School of Environmental and Biological Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA). 4. Plant cell culture as a source of valuable chemicals (Dr Chee-Kok Chin. Department of Plant Biology and Pathology, Rutgers University, New Brunswick, New Jersey, USA). 5. Tomato aroma: biochemistry and biotechnology (Rachel Davidovich-Rikanati and Yaniv Azulay, Institute of Plant Sciences, Newe Ya'ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel Yaron Sitrit. The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Beer-Sheva, Israel and Yaakov Tadmor and Dr Efraim Lewinsohn. Institute of Plant Sciences, Newe Ya'ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel). 6. Flavour development in rice (Louis M. T. Bradbury, Dr Robert J. Henry and Daniel L. E. Waters, Grain Foods CRC, Centre for Plant Conservation Genetics, Southern Cross University, Lismore, NSW 2480 Australia). 7. Breeding and biotechnology for flavor development in apple (Malus x domestica Borkh) (Dr Susan K. Brown, Department of Horticultural Sciences, Cornell University, Geneva, New York, USA). 8. Aroma as a factor in the breeding process of fresh herbs - the case of basil (Dr Nativ Dudai, Aromatic, Medicinal and Spice Crops Unit, ARO - Newe Ya'ar Research Center, Ramat Yishay, ISRAEL and Dr Faith C. Belanger. Department of Plant Biology and Pathology and The Biotechnology Center for Agriculture & the Environment, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA). 9. Increasing the methional content in potato through biotechnology (Rong Di, The Biotechnology Center for Agriculture & the Environment, School of Environmental and Biological Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA). 10. Regulatory aspects of flavor development - traditional versus bioengineered (Dr Sabine Teske and Dr James C. Griffiths, Burdock Group, Vero Beach, Florida and Washington D.C., USA)
The analysis of 30 cases with severe pneumonia (2012)

Objective:To improve the diagnosis and treatment effect on patients with severe pneumonia.Methods:Retrospective analysis of the clinical data of 30 cases with severe pneumonia was conducted.Results People caught severe pneumonia mostly in spring and winter,the clinical characteristics were not typical and the symptoms were complications outside the lung.Conclusion Improving the prognosis of pneumonia in the patients relies on early diagnosis and timely treatment,in order to shorten the course and reduce the cost of treatment.
Specific Absorption Rates in a Flat Phantom in the Near-Field of Dipole Antennas (2006)

National and international regulatory bodies require compliance testing procedures for hand-held wireless telephones. The IEEE has promulgated a compliance verification procedure (P1528) to be followed in verifying whether a wireless phone is compliant with international standards. Manufacturers are required to assess the maximum near-field exposures that phones might produce in the head of a user. A recent intercomparison of the testing procedure has involved the cooperation of 15 government and industrial laboratories. These laboratories measured the 1- and 10-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> cubic volume-averaged specific absorption rates (SARs) in a flat phantom filled with a standardized lossy dielectric fluid. The phantom absorber was placed in the near field of a custom dipole antenna. In support of this effort, we have performed a theoretical analysis of the expected SARs in the measurement system, which has allowed comparison with experiment. We have also been able to compare the 1and 10-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> volume-averaged SARs for cubic and maximum SAR volumes. There is generally good agreement between experimental and theoretical SAR spatial patterns, and SARs averaged over 1- and 10-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> cubic volumes. The 1- and 10-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> average SARs in the shapes giving maximum SARs are about 35% larger compared to cubic volumes
ELASTIC WAVES IN A NATURALLY CURVED ROD (1961)

The propagation is considered of free elastic waves of small amplitude in a naturally curved rod where the neutral axis forms a plane curve of constant radius. The effects of rotatory inertia and radial shear are included, in the same way as in Timoshenko's theory for straight rods, as well as the effect of the extension of the neutral axis. When the curvature is slight there are considerable simplifications and a Timo-shenko-type equation is obtained which governs the nexural motion. A simple relationship is then found with the phase velocity of nexural waves in the straight rod. This means that data already available for straight rods are now readily applicable to slightly curved rods of the same material and cross-section.
Seasonal study of grazing by metazoan zooplankton in the mesohaline Chesapeake Bay (1992)

Grazing of phytoplankton by the metazoan zooplankton community was measured on 5 dates from March to August 1987, and 4 dates from March to October 1988 at a single station in the mesohaline Chesapeake Bay, USA. In situ grazing measurements were made on several taxa including copepod nauplii and meroplanktonic larvae. Zooplankton grazing was dominated by Acartia species copepods in March and August, polychaete larvae in May, and the cyclopoid copepod Oithona colcarva in June 1987 and October 1988. Copepod nauplii were nearly always important grazers because of their relatively high biomass and weight-specific ingestion rates. The amount of daily phytoplankton production removed by zooplankton in 1988 varied between 12 and 103 %, with March > August > October > May.
On Data Wastage in Viewport-Dependent Streaming (2019)

Omnidirectional videos are becoming more and more popular as display devices, such as Head Mounted Displays (HMD), become more user friendly. One of the biggest challenges with such video content is the great amount of bandwidth required for delivery at a good quality. The key difference between omnidirectional and the traditional content streaming is that with the former, users watch only part of the streamed content. Therefore, the non-watched areas of a streamed omnidirectional video are delivered unnecessarily. To reduce the network bandwidth requirements, the delivery mechanism could make use of Viewport-Dependent Streaming (VDS), according to which high-quality (HQ) video is maintained only in the current viewport, while lower quality video is streamed for the remaining part. In this paper, we examine the streaming data wastage, i.e., the parts of HQ video not watched by a user, in VDS when users linearly move from a generic viewport to another one within the 360 degrees space. We used both simulated trajectories as well real trajectories from 20 users. We show how the user's HMD exploration speed and the DASH transport segment lengths impact the streaming data wastage, leading up to 78% of wasted HQ content and up to 40% of total stream bit rate wasted due to users' motion. We also show how the users' trajectory prediction can decrease the streaming data wastage making the system up to 25% more efficient. This paper gives very useful hints that could lead to VDS optimizations, and it introduces quantitative estimates on how the data wastage characteristics change with respect to the streaming parameters.
SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest (2015)

Protein kinase D (PKD) has been implicated in many aspects of tumorigenesis and progression, and is an emerging molecular target for the development of anticancer therapy. Despite recent advancement in the development of potent and selective PKD small molecule inhibitors, the availability of in vivo active PKD inhibitors remains sparse. In this study, we describe the discovery of a novel PKD small molecule inhibitor, SD-208, from a targeted kinase inhibitor library screen, and the synthesis of a series of analogs to probe the structure-activity relationship (SAR) vs. PKD1. SD-208 displayed a narrow SAR profile, was an ATP-competitive pan-PKD inhibitor with low nanomolar potency and was cell active. Targeted inhibition of PKD by SD-208 resulted in potent inhibition of cell proliferation, an effect that could be reversed by overexpressed PKD1 or PKD3. SD-208 also blocked prostate cancer cell survival and invasion, and arrested cells in the G2/M phase of the cell cycle. Mechanistically, SD-208-induced G2/M arrest was accompanied by an increase in levels of p21 in DU145 and PC3 cells as well as elevated phosphorylation of Cdc2 and Cdc25C in DU145 cells. Most importantly, SD-208 given orally for 24 days significantly abrogated the growth of PC3 subcutaneous tumor xenografts in nude mice, which was accompanied by reduced proliferation and increased apoptosis and decreased expression of PKD biomarkers including survivin and Bcl-xL. Our study has identified SD-208 as a novel efficacious PKD small molecule inhibitor, demonstrating the therapeutic potential of targeted inhibition of PKD for prostate cancer treatment.
A Partial Estrogen Receptor Agonist With Strong Antiatherogenic Properties Without Noticeable Effect on Reproductive Tissue in Cholesterol-Fed Female and Male Rabbits (1997)

Estrogen replacement therapy retards the development of cardiovascular disease and osteoporosis in postmenopausal women. However, long-term unopposed use increases the risk of cancer in endometrium and possibly in breast. The racemic compound ormeloxifene, widely used in India as an antifertility agent, is a partial estrogen receptor agonist with antiosteoporotic properties. The present study was undertaken to investigate the effect of the L-enantiomer (levormeloxifene) and the d-enantiomer (d-ormeloxifene) on the development of atherosclerosis. In a short-term experiment (6 weeks), 4 x 10 ovariectomized female rabbits were fed a 0.25% cholesterol-enriched diet and the effect on plasma cholesterol levels was studied. In a long-term experiment (13 weeks), 4 x 15 ovariectomized female and 4 x 15 shamoperated male rabbits were maintained at a similar plasma cholesterol level of 25 mmol/L and the effect on undamaged and balloon-injured arterial wall was studied. In both experiments, the rabbits were treated with levormeloxifene, d-ormeloxifene, 17 beta-estradiol, or placebo, respectively. In the short-term experiment, levormeloxifene, in contrast to d-ormeloxifene, significantly reduced plasma cholesterol by 30% compared with the placebo group. In the long-term experiment, levormeloxifene, in contrast to d-ormeloxifene, significantly reduced atherosclerosis by 50% in the undamaged arterial wall of both female and male rabbits. Because these rabbits were cholesterol-clamped, the antiatherogenic effect was not mediated via plasma cholesterol lowering. Like estrogen, levormeloxifene did not inhibit atherosclerosis in the endothelium-denuded site of aorta. The antiatherogenic effects of levormeloxifene were thus similar to those of estrogen, but produced in the absence of any noticeable estrogenic effect on uterine or testicular tissue.
LiFeP04Battery Modeling and Drive Cycle Loss Evaluation in Cascaded H-Bridge Inverters for Vehicles (2019)

This paper deals with the modeling and parameterization of LiFeP0 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> batteries when used in cascaded H-bridge multilevel inverter drive systems. Since the battery packs are intermittently conducting the motor currents, the battery cells are stressed with a dynamic current waveform containing a substantial amount of low order harmonic components in the range of a couple of kHz. Different battery models like a pure resistive or different RC networks are considered, to determine the battery losses. Measurements of the voltage drop for a pulsed current of variable frequency and magnitude are done to be able to determine the model parameters. The models are then verified against measurements on a battery pack placed in a small scale multilevel inverter operated at 6 different operating point that are representative for the operation of an electrified vehicle. It is shown that the dynamic model agrees very well with the measurements for all operating points analyzed with a maximum deviation of 4 %. The results are also compared with the commonly used resistive model which overestimates the losses with typically around 20 % for the evaluated points. Simulations of 4 full drive cycles are performed where it is stated that the resistive model always shows about 20 % more losses compared to the 3 time constant model.
Chagas Disease Control Programme in Brazil: a study of the effectiveness of 13 years of intervention. (1998)

Reported is an evaluation of 13 years of intervention by the Chagas Disease Control Programme in an endemic area (Montalvania) in the State of Minas Gerais, Brazil. The design used was an epidemiological panel study. The reduction of Trypanosoma cruzi infection rates was estimated from data collected on three separate occasions: a serological survey in 1975-80, a quasi-experimental study in 1987, and the present investigation. A random sample of 156 households was selected and blood samples were collected from 653 inhabitants. The data routinely collected by the control programme were analysed to correlate the results with the incidence of T. cruzi. The overall prevalence of infection was 2.3%; however, no participant under 14 years of age was found to have a positive serological test. The total reduction in T. cruzi infection rates in this area from the start of the programme's activities was estimated to be 83.5%. Cross-sectional comparisons for the age groups 2-6 years and 7-14 years indicated a 100% reduction in T. cruzi incidence rates; but cohort comparisons showed that 100% reduction was achieved only for the 2-6-years age group.
Multi-environment NLF tracking assessment testbed (MENTAT): an update (2006)

In applications in which even the best EKFs and MHTs may perform poorly, the single-target and multi-target Bayes nonlinear filters become potentially important. In recent years, new implementation techniques such as sequential Monte Carlo (a.k.a. particle-system) have emerged that, when hosted on ever more inexpensive, smaller, and powerful computers, make these filters potentially computationally tractable for real-time applications. A methodology for preliminary test and evaluation (PT&E) of the relative strengths and weaknesses of these algorithms is becoming increasingly necessary. The purpose of PT&E is to (1) assess the broad strengths and weaknesses of various algorithms or algorithm types; (2) justify further algorithm development; and (3) provide guidance as to which algorithms are potentially useful for which applications. At last year's conference we described our plans for the development of a PT&E tool, MENTAT. In this paper we report on current progress. Our implementation is MATLAB-based, and harnesses the GUI-building capabilities of the well-known MATLAB package, SIMULINK.