gebhart/patrepeval huggingface dataset:
Inhibition of Epidermal Growth Factor Receptor and PI3K/Akt Signaling Suppresses Cell Proliferation and Survival through Regulation of Stat3 Activation in Human Cutaneous Squamous Cell Carcinoma (2010)

Recent studies have emphasized the important role of Stat3 activation in a number of human tumors from the viewpoint of its oncogenic and antiapoptotic activity. In this study, we examined the role and related signaling molecules of Stat3 in the carcinogenesis of human cutaneous squamous cell carcinoma (SCC). In 35 human cutaneous SCC samples, 86% showed overexpression of phosphorylated (p)-Stat3, and most of those simultaneously overexpressed p-EGFR or p-Akt. Constitutive activation of EGFR and Stat3 was observed in three SCC cell lines and four of five SCC tissues. AG1478, an inhibitor of the EGFR, downregulated Stat3 activation in HSC-1 human SCC cells. AG1478 inhibited cell proliferation and induced apoptosis of HSC-1 cells but did not inhibit the growth of normal human epidermal keratinocytes that did not show Stat3 activation. Furthermore, a PI3K inhibitor also suppressed Stat3 activation in HSC-1 cells to some degree. Combined treatment with the PI3K inhibitor and AG1478 strongly suppressed Stat3 activity and dramatically induced apoptosis of HSC-1 cells. These data suggest that Stat3 activation through EGFR and/or PI3K/Akt activation plays a critical role in the proliferation and survival of human cutaneous SCC.
A Study of Intermediate Temperature Proton-Conductive Phosphate Electrolytes (2008)

The ternary oxide compositions xZrO2-(0.5–x/2)Al2O3-yP2O5(x=0.8, 0.9, 0.95, 1.0; y=1.0, 1.2, 1.4) and 0.9ZrO2-0.05In2O3-1.4P2O5, xSiO2-(0.5–x/2)Al2O3-1.4P2O5(x=0.9, 1.0) were synthesized by sol-gel methods, and their conductivities were investigated by ac-impedance spectroscopy. The conductivity increased with increasing P2O5 content and with decreasing heat-treatment temperature. The maximum conductivities reached over 10-2 Scm-1 at 150°C for 0.9ZrO2-0.05Al2O3-1.4P2O5 and at 225°C for 0.9SiO2-0.05Al2O3-1.4P2O5.
An unprecedented hetero-bimetallic three-dimensional spin crossover coordination polymer based on the tetrahedral [Hg(SeCN)4]2−building block (2019)

A new non-Hoffmann type of hetero-bimetallic Hg<sup>II</sup>–Fe<sup>II</sup>spin-crossover coordination polymer has been structurally and magnetically investigated.
Protein Kinase C Activators and Calcium-Mobilizing Agents Synergistically Increase GH, LH, and TSH Secretion from Anterior Pituitary Cells (1986)

A series of studies was designed to determine the effects of protein kinase C activators on TSH, LH, and GH release from anterior pituitary cells. A 15-min incubation of cultured pituitary cells with synthetic diacylglycerol or phorbol myristate acetate, stimulators of protein kinase C, increased GH, LH, and TSH release. Similarly phospholipase C, which liberates endogenous diacylglycerol, stimulated GH, LH, and TSH secretion. The potentiation of the effects of protein kinase C activators is achieved by calcium mobilization in various cell types. The results of the present studies show that calcium ionophore A23187 or calcium channel activator maitotoxin potentiate diacylglycerol-, phorbol ester-, or phospholipase C-induced GH, LH, or TSH release. These findings suggest that activation of protein kinase C by diacylglycerol and mobilization of calcium may be synergistically involved in the regulation of GH, LH, and TSH release.
Abstract P230: Risk of Venous Thromboembolism in Acutely Ill Medical Patients and the Influence of Timely Ambulation (2011)

Background: Ambulatory status is often considered a criterion for stopping prophylaxis for venous thromboembolism (VTE) in medically ill patients. Methods: A subgroup analysis of the Prophylaxis in Medical Patients with Enoxaparin (MEDENOX) trial was performed according to ambulatory status. Ambulatory status was defined as the ability to attain autonomous walking distance of &gt; 10 meters assessed at visit day 10 ± 4. Incidence of VTE and bleeding was evaluated. Results: The majority of patients (607 of 1084) were ambulatory at visit day 10 ± 4, with a mean time to ambulation of 4.4 days. Thromboprophylaxis was provided for a mean of 7.3 days in the ambulatory subgroup and 7.9 days in the non-ambulatory subgroup. Main results are displayed in the graph. Major bleeding was not significantly different between enoxaparin 40 mg once daily versus placebo in the ambulatory (1 of 212 vs 1 of 190, respectively) or non-ambulatory subgroups (5 of 146 vs 3 of 169). In a multivariate logistic regression model to assess which factors influenced the probability of individual patients becoming ambulatory, ambulatory patients were less likely than non-ambulatory patients to be aged &gt; 75 years (OR 0.57; 95% CI 0.43-0.75; P &lt; 0.0001) and to have a previous history of VTE (OR 0.61; 95% CI 0.38-0.95; P = 0.03). Provision of VTE prophylaxis or placebo did not affect ambulatory status. Conclusions: Despite timely mobilization, medically ill patients who become ambulatory in hospital remain at substantial risk of VTE and have significant VTE risk reduction with enoxaparin 40 mg once daily, as also observed in non-ambulatory patients. Ambulatory status is significantly influenced by baseline characteristics.
Electronic structure ofMoSe2,MoS2, andWSe2. I. Band-structure calculations and photoelectron spectroscopy (1987)

The band structures of the semiconducting layered compounds ${\mathrm{MoSe}}_{2}$, ${\mathrm{MoS}}_{2}$, and ${\mathrm{WSe}}_{2}$ have been calculated self-consistently with the augmented-spherical-wave method. Angle-resolved photoelec- tron spectroscopy of ${\mathrm{MoSe}}_{2}$ using He i, He ii, and Ne i radiation, and photon-energy-dependent normal-emission photoelectron spectroscopy using synchrotron radiation, show that the calculational results give a good description of the valence-band structure. At about 1 eV below the top of the valence band a dispersionless state was measured, almost completely of Mo 4d character. Such a state, which is not predicted by band-structure calculations, has also been observed in metallic layered compounds. Suggestions are given for the explanation of this phenomenon.
Fluorescent derivatives of strophanthidin. Interaction with sodium- and potassium-activated adenosine triphosphatase (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorescent derivatives of strophanthidin. Interaction with sodium- and potassium-activated adenosine triphosphataseFranz Oesch, James A. Waters, John W. Daly, and Bernhard WitkopCite this: J. Med. Chem. 1972, 15, 7, 757–759Publication Date (Print):July 1, 1972Publication History Published online1 May 2002Published inissue 1 July 1972https://pubs.acs.org/doi/10.1021/jm00277a015https://doi.org/10.1021/jm00277a015research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Laser-assisted Metal Spinning of Challenging Materials (2014)

A new laser integration into a spinning machine was developed offering the flexibility to apply completely new processing strategies for laser-assisted multi-pass metal spinning. In this process the formability of challenging materials is improved by selective heating of the forming zone by means of laser. In order to decrease the strength and increase the formability of titanium (grade 2) experimental investigations have been performed to generate a suitable temperature field in the workpiece.
Synthesis of Melatonin Analogues Derived from Furo[2,3-b]- and [2,3-c]pyridines by Use of a Palladium-Copper Catalyst System (2002)

2,3,5-Substituted furo[2,3-b]pyridine was synthesised by palladium-catalyzed reaction of 5-bromo-2-hydroxy-3-iodopyridine and phenylacetylene with (Ph 3 P) 2 PdCl 2 , CuI in Et 3 N.A carbonylative cyclization of 5-hydroxy-2-methoxy-4-(2-phenylethynyl)pyridine with carbon monoxide in methanol with PdCl 2 , CuCl 2 under basic conditions, has been accomplished to prepare methyl 2,5-substituted furo[2,3-c]pyridine-3-carboxylate.In the course of our research on the synthesis of melatonin analogues, 1 our attention has been focused on developing a catalytic approach to the furopyridine derivatives (1) and (2).Several studies have shown that 2-substituted melatonin analogues can be more potent than melatonin itself. 2 This increase in potency has been ascribed to the presence of a C-2 binding site.Thus, to take advantage of this increase in binding, we envisaged to synthesize furopyridines analogues substituted with a phenyl group at the C-2 position whilst keeping the 5-methoxy group and the 3-ethanamide side chain present in melatonin itself. MelatoninIt was reported that the reaction of 2-hydroxypyridinyl iodides with variety of 1-alkynes in the presence of palladium (II) and copper iodide as co-catalyst provided 2-substituted furopyridines. 3 The synthesis of two kinds of furopyridines, which were expected to be obtainable by the above-mentioned method, was examined.Initial studies were directed to the preparation of the suitable substrates
In caco-2 cells, most of the "apical" SGLT1 resides in intracellular, microtubuli-associated vesicles (2002)

We investigated the distribution of the endogenous sodium/D-glucose cotransporter (SGLT1) in polarized Caco-2 cells, a model for enterocytes. A cellular organelle fraction was separated by free flow electrophoresis and subjected to the analysis of endogenous and exogenous marker enzymes for various membrane vesicle components. Furthermore, the presence of SGLT1 was tested by an ELISA assay using newly developed epitope-specific antibodies. Thereby it was found that the major amount of SGLT1 resided in intracellular compartments and only a minor amount in apical plasma membranes. The distribution ratio between intracellular SGLT1 and apical membrane-associated SGLT1 was ~2:1. Further immunohistochemical investigation of SGLT1 distribution in fixed Caco-2 cells by epifluorescence and confocal microscopy revealed that the intracellular compartments containing SGLT1 were associated with microtubuli. Elimination of SGLT1 synthesis by incubation of cells with cycloheximide did not significantly reduce the size of the intracellular SGLT1 pool. Furthermore, the half-life of SGLT1 in Caco-2 cells was determined to be 2.5 d by metabolic labeling followed by immunoprecipitation. Our data suggest that most of the intracellular SGLT1 are not transporters en route from biosynthesis to their cellular destination, but represent an intracellular reserve pool. We therefore propose that intracellular compartments containing SGLT1 are involved in an endo-/exocytosis process, which regulates SGLT1 abundance at the apical cell surface.
Radiographic Imaging of the Cochlear Implant Candidate: Preliminary Results (1986)

Preoperative radiographic imaging of the temporal bone is well accepted in otology for both the diagnosis of disease and the delineation of anatomic structure for surgical planning. Until recently radiographic techniques have unfortunately failed to demonstrate fibrous or bony obstruction of the basal turn of the cochlea, which may cause difficulties during cochlear implantation. Intraoperative findings have been correlated with preoperative imaging in a consecutive group of six cochlear implant recipients and a series of consistent radiographic signs that may indicate the presence of obstruction of the scala tympani have been identified. A classification system has been developed. Based on thin-section high-resolution computerized tomography (HRCT), the system has been used preoperatively on six cochlear implant recipients. In addition, a systematic evaluation of the temporal bone has been developed for precochlear implant evaluation. This includes the thickness of the parietal bone for seating of the receiving device, the degree of pneumatization of the mastoid, the measurement of the size of the facial recess, the description of the size and orientation of the round window niche, and the patency of the basal turn of the cochlea.
The synthesis of high-quality diamond in combustion flames (1990)

High-quality diamond with good crystallinity has been successfully synthesized on a substrate using an oxy-acetylene combustion flame in the atmosphere. The crystal grains under some conditions have good optical transparency. The deposition rate of transparent diamond depended strongly on substrate temperatures and the O2/C2H2 ratio and averaged ∼30 μm/h. The substrate temperature for the growth of optically transparent crystals was 500–750 °C, which is relatively low compared with other chemical vapor deposition methods. The optical transparency is attributed to the low defect densities in the crystals, as determined by transmission electron microscope, which results from the low substrate temperatures and moderate growth rates. Raman spectroscopy and x-ray diffraction data on the synthesized crystals were comparable with that of natural diamond. The synthesis conditions and corresponding diamond quality as well as emission spectrum analysis of the combustion flame during diamond synthesis are described.
<title>Robust parallel clustering algorithm for image segmentation</title> (1996)

This paper describes a hierarchical parallel implementation of two clustering algorithms applied to the segmentation of multidimensional images and range images. The proposed hierarchical parallel implementation results in a fast robust segmentation algorithm that can be applied in a number of practical computer vision problems. The clustering process is divided in two basic steps. First, a fast sequential clustering algorithm performs a simple analysis of the image data, which results in a sub optimal classification of the image features. Second, the resulting clusters are analyzed using the minimum volume ellipsoid estimator. The second step is to merge the similar clusters using the number and shape of the ellipsoidal clusters that best represents the data. Both algorithms are implemented in a parallel computer architecture that speeds up the classification task. The hierarchical clustering algorithm is compared against the fuzzy k-means clustering algorithm showing that both approaches gave comparable segmentation results. The hierarchical parallel implementation is tested in synthetic multidimensional images and real range images.
Essential Oil Constituents ofTrachyspermum copticum(L.) Link Fruits (1993)

ABSTRACT The essential oil, which was obtained by steam distillation of fruits of Trachyspermum copticum (L.) Link harvested in Turkey, was analyzed direcdy by GC and GC/MS. Twenty-seven compounds were identified of which thymol (61%) was present in greatest quantity. Other major components were p-cymene (15.6%) and γ-terpinene (11.9%)
Orbital flux integrations: Parameter values for effective computer time reductions (1974)

To improve computer utilization and to reduce the cost of orbital flux integrations, the effects of integration parameters 'duration' (T) and 'stepsize' (delta t) on integration results were investigated. Over given ranges of T and delta t, and within specified acceptable accuracy restraints, optimal values of these parameters were established for circular subsynchronous trajectories, in terms of the variables altitude (H) and inclination (i). It is shown that (1) above a certain statistically important value, duration is independent of both h and i; (2) stepsize has a relative altitude dependence; and (3) stepsize is not a function of inclination. The substantial savings in computer time are discussed along with the possibility of greater savings by relaxing accuracy restrictions while not exceeding the minimum model-associated uncertainty factors of the environments.
Reference Values for IGF-I throughout Childhood and Adolescence: A Model that Accounts Simultaneously for the Effect of Gender, Age, and Puberty (2001)

We have constructed a reference model to facilitate comparison of serum IGF-I values among children, and thereby to improve the value of IGF-I measurements for diagnosis. The data set consists of serum values measured in 969 samples from 468 healthy children and adolescents (232 males, 236 females; ages, 1.1-18.3 yr). One sample per child was used for the model, each being selected so as to provide sufficient observations for each stage of puberty. The samples not selected were used to validate the reference data. The IGF-I values were log transformed, and multiple regression analysis was used in the model-building process. The best linear model, which converts serum IGF-I concentrations into SD scores and explains 66% of the variation in logIGF-I values, includes the variables of age, gender, and puberty, and takes the interactions among these variables into account. In prepubertal and early pubertal children, the relationship between age and logIGF-I was positive, with greater effect in girls older than 8 yr. In mid-puberty, logIGF-I values were higher in girls than in boys of the same age, up to 16 yr of age. Among boys, the most pronounced positive relationship between age and logIGF-I occurred in mid-puberty, whereas the relationship between age and logIGF-I among girls in mid-puberty is fairly constant. In late puberty, logIGF-I values were higher than earlier in puberty, and there was a negative relationship with age in both boys and girls. Instead of separate models for each combination of puberty and gender, estimating a single regression model permits simultaneous estimation of all explanatory variables and uses all observations in the data set, thereby making it easier to select those variables that have a significant effect on logIGF-I. Our model shows that IGF-I levels are related to age during each stage of puberty. The model also accounts for the fact that serum IGF-I concentrations during puberty are different for boys and girls.
Dynamic Compression Method Using Wireless Resource Allocation for Digitized Radio over TDM-PON System (2014)

We developed a prototype of a network adapter that implements the dynamic compression method for digitized radio over TDM-PON systems. Experimental results show that the required PON bandwidth can be reduced to 1/8.
Manual of the vascular plants of Texas (1970)

This manual of the Texas flora is a monumental work and the authors, D. S. Correll and M. C. Johnston, as well as their collaborators, deserve the compliments of syste matists on its publication. A definitive treatment of a large and complex flora (174 families, 1216 genera, 4839 species and 576 subspecies and varieties in Texas) must depend to a considerable extent upon the labors of predecessors. There has been a long and active series of collectors and publishers interested in Texas plants, and they have pro vided an excellent basis for a comprehensive flora. How ever, the special research on the Texas flora by the authors, and their extensive field experience with it, have brought to this publication an important element of personal knowl edge. Fifty-six collaborators have provided the treatments of 20 families and of 38 separate genera. Both the authors and the collaborators are to be congratulated upon this productive cooperation. The book is well made up and the format and typography make it easy to use. An introduction provides a brief ac count of the principal vegetation regions in Texas. This is followed by a key to the families and the taxonomic treat ment of the flora, which encompasses 1700 pages. A brief appendix adds critical comments and some additional spe cies from data obtained during the course of publication. The list of Abbreviations of Authors' Names deserves special mention. It is in fact far more than the title states. It includes birth and death dates, and a variety of other information such as the principal professional position, or other occupation, major publications, groups or floras studied, and sometimes mention of other significant contri butions to botany. The inclusion of this information will
Correlation between the piezo-Barkhausen effect and the fatigue limit of steel (2012)

Abstract Many types of ferrous metals can sustain an indefinite number of repeated loading cycles ( N ⩾ 10 7 cycles) provided that the maximum imposed stresses do not exceed certain critical values usually referred to as fatigue or endurance limits. In current practice, these limits are primarily inferred from statistical analyses of numerous fatigue experiments that relate the number of cycles to failure, N f , to the loading programs. Numerous attempts have been made to bypass these time consuming tests by the direct observation of changes in material microstructures utilizing a variety of physical effects ranging from neutron diffraction, x-ray radiography, acoustic emission and even positron radiation patterns; but none of these approaches has yielded any unambiguous indices of damage. Recently, it has been found that the evolution of piezomagnetic hysteresis, due to magnetization changes induced in ferromagnetic steels by tension and compression, is a reliable indicator of the development of fatigue damage and can lead to practical predictions of service life. Further detailed information concerning processes at the microstructural level can be obtained from measurements of flux jumps associated with the piezomagnetic fields. Sequences of flux variations of the order of 10 −3 Mx or 10 −11 Wb, comparable to those observed in conventional Barkhausen experiments, appear when ferromagnetic steels are subjected to tension or compression. The amplitude distribution of these piezo-Barkhausen pulses increases markedly in the vicinity of the endurance limit and appears to provide a rapid means for distinguishing between stable, i.e. safe, loading regimes and those terminating in fatigue failure.
Rate-Distortion Optimized Reference Picture Management for High Efficiency Video Coding (2012)

Motion compensation with multiple reference pictures has been widely used during the development of the emerging High Efficiency Video Coding (HEVC) standard, which greatly helps to improve the coding efficiency. Usually, a heuristic strategy is exploited to use the nearest reconstructed pictures as references. However, such a strategy may not be efficient on all occasions, especially when different content characteristics and coding settings are considered. In this paper, we investigate how to manage reference pictures so as to achieve better rate-distortion performance under the memory constraint of the decoded picture buffer at the decoder. We formulate the reference picture management as an optimization problem and approximate its optimal solution. Moreover, we explore how to adjust quality for each picture according to the reference structure to further improve coding efficiency. For some coding cases, where a complicated encoder optimization is unaffordable, we also develop fast algorithms to get the most benefit from reference picture selection. Among them, one strategy has been adopted by the HEVC software and common test conditions to generate the anchor. Experimental results show that the proposed full search algorithm and fast search algorithms achieve significant bitrate reduction.