gebhart/patrepeval huggingface dataset:
miR-375 Is Activated by ASH1 and Inhibits YAP1 in a Lineage-Dependent Manner in Lung Cancer (2011)

Lung cancers with neuroendocrine (NE) features are often very aggressive but the underlying molecular mechanisms remain elusive. The transcription factor ASH1/ASCL1 is a master regulator of pulmonary NE cell development that is involved in the pathogenesis of lung cancers with NE features (NE-lung cancers). Here we report the definition of the microRNA miR-375 as a key downstream effector of ASH1 function in NE-lung cancer cells. miR-375 was markedly induced by ASH1 in lung cancer cells where it was sufficient to induce NE differentiation. miR-375 upregulation was a prerequisite for ASH1-mediated induction of NE features. The transcriptional coactivator YAP1 was determined to be a direct target of miR-375. YAP1 showed a negative correlation with miR-375 in a panel of lung cancer cell lines and growth inhibitory activities in NE-lung cancer cells. Our results elucidate an ASH1 effector axis in NE-lung cancers that is functionally pivotal in controlling NE features and the alleviation from YAP1-mediated growth inhibition.
Transient collisional excitation X-ray lasers with 1-ps tabletop drivers (1999)

Recent results are presented for 1-ps driven X-ray laser amplification in Ne-like and Ni-like transient collisional excitation research at the Lawrence Livermore National Laboratory. Plasma formation, ionization and collisional excitation are optimized using two laser pulses of 600- and 1-ps duration at tabletop energies of typically 5 J or less in each beam. Gain of 35 cm/sup -1/ and higher has been measured on the 147 /spl Aring/ 4d/spl rarr/4pJ=0/spl rarr/1 transition of Ni-like Pd and is a direct consequence of the nonstationary population in, version produced by the high intensity picosecond pulse. We report the characterization of the X-ray laser properties including the transient gain lifetime and beam divergence for different Ne-like and Ni-like X-ray lasers.
Forbidden forests in Priestley spaces (2004)

We present a first order formula characterizing the distributive lattices L whose Priestley spaces P(L) contain no copy of a forest T . For Heyting algebras L, prohibiting a poset T in P(L) is characterized by equations i T is a tree. We also give a condition characterizing the distributive lattices whose Priestley spaces contain no copy of a forest with a single additional point at the bottom.
Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC) (2020)

A novel four stage Cascade of Moving Baffle Oscillatory Crystallisers (CMBOC) is developed, characterised and implemented for continuous crystallisation of pharmaceuticals.
Breast Reconstruction with Enhanced Stromal Vascular Fraction Fat Grafting (2015)

Celution and Fatstem were the 2 best automatic systems to obtain SVF and to improve maintenance of fat volume and prevent the reabsorption.
Structural Stiffness and Coulomb Damping in Compliant Foil Journal Bearings: Theoretical Considerations (1994)

Compliant foil bearings operate on either gas or liquid, which makes them very attractive for use in extreme environments such as in high-temperature aircraft turbine engines and cryogenic turbopumps. However, a lack of analytical models to predict the dynamic characteristics of foil bearings forces the bearing designer to rely on prototype testing, which is time-consuming and expensive. In this paper, the authors present a theoretical model to predict the structural stiffness and damping coefficients of the bump foil strip in a journal bearing or damper. Stiffness is calculated based on the perturbation of the journal center with respect to its static equilibrium position. The equivalent viscous damping coefficients are determined based on the area of a closed hysteresis loop of the journal center motion. The authors found, theoretically, that the energy dissipated from this loop was mostly contributed by the frictional motion between contact surfaces. In addition, the source and mechanism of the nonlinear behavior of the bump foil strips were examined. With the introduction of this enhanced model, the analytical tools are now available for the design of compliant foil bearings.
Evaluation of Intrapedicular Screw Position Using Intraoperative Evoked Electromyography (1995)

Evoked electromyography is a valuable sensitive adjunct to radiographic examination of pedicle drill bit and screw placement.
Fairness in Biometrics: a figure of merit to assess biometric verification systems (2020)

Machine learning-based (ML) systems are being largely deployed since the last decade in a myriad of scenarios impacting several instances in our daily lives. With this vast sort of applications, aspects of fairness start to rise in the spotlight due to the social impact that this can get in minorities. In this work aspects of fairness in biometrics are addressed. First, we introduce the first figure of merit that is able to evaluate and compare fairness aspects between multiple biometric verification systems, the so-called Fairness Discrepancy Rate (FDR). A use case with two synthetic biometric systems is introduced and demonstrates the potential of this figure of merit in extreme cases of fair and unfair behavior. Second, a use case using face biometrics is presented where several systems are evaluated compared with this new figure of merit using three public datasets exploring gender and race demographics.
Active neutron multiplicity analysis and Monte Carlo calculations (1994)

Active neutron multiplicity measurements of high-enrichment uranium metal and oxide samples have been made at Los Alamos and Y-12. The data from the measurements of standards at Los Alamos were analyzed to obtain values for neutron multiplication and source-sample coupling. These results are compared to equivalent results obtained from Monte Carlo calculations. An approximate relationship between coupling and multiplication is derived and used to correct doubles rates for multiplication and coupling. The utility of singles counting for uranium samples is also examined.
A Survey of House Dust Mite Allergen Contamination in House (2006)

House dust mite was the most important cause of allergic asthma and rhinitis. More than 70% of Korean children and about 50% of adult with respiratory allergy were sensitive to house dust mite. This experiment was indoor environment in house and house dust mite existence inquiry. From 23rd December 2005 to 28th February 2006, dust samples were collected from the bedclothes by a vacuum cleaner and air sampler And the levels of Der f1 and Der p1 were determined by ELISA((Enzyme-Linked Immunosorbent Assay). The results were as follows : 1 The dust mites allergy contaminations of bedclothes in house were higher than international standards(2000 ng/g). 2. In type of dust mite, the Korean house the almost have the D. farinae other than D. pteronyeeinus of mite. 3. The Der f1 and Der p1 levels per gram of dust from the bedclothes were 2074.99 ng on average, but they did not exist in air. The concentrations of house dust mite were significantly high in the bedclothes. This results suggest that the bedclothes have enough concentrations of dust mites to develop the sensitization. The control of indoor environment should be emphasized to prevent the sensitization by the repeated exposure to dust mite.
Cognitive endophenotypes in a family with bipolar disorder with a risk locus on chromosome 4 (2013)

Verbal learning and semantic verbal fluency impairments may represent a cognitive endophenotype for both bipolar disorder and major depression in relatives of bipolar disorder patients, as impairment was also present in high-risk relatives who had not developed any affective disorder symptoms. These findings suggest that impairment in semantic organization may be linked to the genetic aetiology of bipolar disorder.
Differentially pumped spray deposition as a rapid screening tool for organic and perovskite solar cells (2016)

We report a spray deposition technique as a screening tool for solution processed solar cells. A dual-feed spray nozzle is introduced to deposit donor and acceptor materials separately and to form blended films on substrates in situ. Using a differential pump system with a motorised spray nozzle, the effect of film thickness, solution flow rates and the blend ratio of donor and acceptor materials on device performance can be found in a single experiment. Using this method, polymer solar cells based on poly(3-hexylthiophene) (P3HT):(6,6)-phenyl C61 butyric acid methyl ester (PC61BM) are fabricated with numerous combinations of thicknesses and blend ratios. Results obtained from this technique show that the optimum ratio of materials is consistent with previously reported values confirming this technique is a very useful and effective screening method. This high throughput screening method is also used in a single-feed configuration. In the single-feed mode, methylammonium iodide solution is deposited on lead iodide films to create a photoactive layer of perovskite solar cells. Devices featuring a perovskite layer fabricated by this spray process demonstrated a power conversion efficiencies of up to 7.9%.
Peptides for elucidating the signal tranduction pathways of CTLA-4 and CD28 (2006)

CTLA-4, transiently expressed on the surface of activated T-cells, binds to antigen presenting cell ligands B7.1 and B7.2 with 100 fold higher affinity than it's competitive receptor, CD28. CD28 promotes T-cell activation upon such binding, however, CTLA-4 bound to B7 ligands potently down regulates cytokine production. Upon binding of B7 to either CTLA-4 or CD28, intracellular signal transduction commences via their cytoplasmic tails. The cascade of proteins binding to these cytoplasmic tails and their signal transduction paths are poorly understood beyond initial recruitment of known signal transduction initiators. Peptides, incorporating a biotin tag, emulating these tails were synthesized as monomeric and dimeric constructs varying in states of phosphorylation. These peptides demonstrate functionality by binding to PI3-kinase and SHP-2 phosphatase, which are known to initially bind to these cytoplasmic tails and thought to be initiators of the signal transduction cascades [1]. Peptide characterizations, as demonstrated by Western blotting analysis, show appropriate functionality.
THE DEVELOPMENT PLANNING OF CHINA NATIONAL SERVICE STANDARD OF 2005-2008 (2006)

According to the prime task of readjusting industrial structure, energetically developing service industry, completing service standards and promoting service level, which are raised in the 10th Five-Year Plan Outline of National Economy and Social Development, Standardization Administration of China( SAC ), National Development and Reform Commission, Ministry of Civil Affairs of the People's Republic of China, Ministry of Construction of P.R.C,Ministry of Commerce of the People's Republic of China, Ministry of Culture of the People's Republic of China, the People's Bank of China, General Administration of Quality Supervision, Inspection and Quarantine of P.R.C (AQSIQ), the State Administration of Radio, Film and Television, State General Administration of Sport, National Tourism Administration, China Seismological Bureau, China Meteorological Administration, China Insurance Regulatory Commission, State Post Bureau, State Cultural Relics, State Administration of Traditional Chinese Medicine Bureau, China National Technical Committee 264 on Service of Standardization Administration of China, China Consumers'Association and China National Institute of Standardization had compiled and officially ratified the Development Planning of National Service Standard2005-2008 by the end of 2005.……
Ethernet in the First Mile (2005)

This chapter contains sections titled: Introduction Overview of the IEEE, the process and the 802.3 Working Group Overview of the EFM Task Force and timeline Overview of OAM Overview of copper Overview of optics Overview of EPONs: the logic behind P2MP Summary
[Increase of mast cells in the peritoneal cavity of rats treated with atopic patient's serum]. (1976)

In accordance with the experiments described by the author, the injection of atopic serum and the serum of patients infected with ascaris into the peritoneal cavity of the rats produces after 24 hours an increase in mast cells of the mesentery together with vascular congestion. The experiment was made in the following way: injecting 0.5 ml. of the serum in the peritoneal cavity and the observations were made after 24 hours in the ileum-cecal mesentery. The increase of mast cells is shown to have statistical significance in atopic serum (hay fever and atopic dermatitis) as well as in serum of patients infected with ascaris lumbricoides. The increase of the mast cells is seen particularly in the vascular areas. On the other hand, the injection of non-atopic serum and inactivated atopic serum by heat (56 degrees C, 2 hours) does not produce this increase in mast cells. This phenomenon of the increase of the mast cell population which the atopic serum produces is only observed after 24 hours and not in a shorter time (20 minutes). Also we would emphasize that the increase is due only to the application of the atopic serum without any need to apply the appropriate antigen. The results obtained are as follows:A) 6 control rats--38.6 mast cells/mm2 B) 7 rats + serum of patient with hay fever--88.5 mast cells/mm2 C) 4 rats + inactivated serum (56 degrees C 2 hours) from the same patient with hay fever. 47.0 mast cells/mm2 D) 4 rats + 4 serum from non-atopic persons--38.1 mast cells/mm2 B') 6 rats + 6 serum from patients with hay fever--89.0 mast cells/mm2 C') 4 rats + 4 serums from patients with atopic dermatitis. 108.0 mast cells/mm2 D') 4 rats + 4 serums from patients with ascaris lumbricoides--116.0 mast cells/mm2. Although it is known that the serum from atopic patients and those infected with ascaris lumbricoides has a high level of IgE we cannot be sure that this increase in mast cells in the rat is produced by the human IgE. The true cause of this phenomenon is unknown.
Sodium ion diffusion in layered NaxMnO2(0.49 ≤x≤ 0.75): Comparison with NaxCoO2 (2014)

The temperature (T) dependence of the sodium ion diffusion coefficient D of a NaxMnO2 thin film is extensively investigated versus x and T using electrochemical impedance spectroscopy. D is found to be 5.0 × 10−11 cm2/s at x = 0.54 at 301 K, which is much larger than the value of 0.7 × 10−11 cm2/s at x = 0.54 at 303 K of a NaxCoO2 thin film. In addition, the activation energy of D (= 0.26–0.32 eV) is smaller than that of NaxCoO2 (= 0.31–0.44 eV). The improved Na+ diffusion properties of NaxMnO2 are interpreted in terms of the larger interlayer distance (d = 5.54 Å) of NaxMnO2.
The Static Strength of Syntactic Foams (1969)

A failure condition is proposed for the composite material “syntactic foam” based upon an experimental program carried out under combined biaxial and triaxial stress states. The material itself is composed of hollow glass “microspheres” embedded in an epoxy resin matrix. It exhibits finite strength under hydrostatic compression, unlike any other engineering material and thus gives rise to a closed failure surface in principal stress space. In addition to loadings corresponding to radial lines starting from the origin in stress space out to the failure envelope, other load paths were also used. Some effects due to loading and unloading and then reloading to another stress state were also investigated. Under biaxial stress states it was found that the ultimate strength of the material is sensitive to its past stress history to some degree, the reason being attributed to the initially isotropic material developing weak planes perpendicular to the compressive principal stress resulting in a “latent anisotropy.”
A hybrid nanomemristor/transistor logic circuit capable of self-programming (2009)

Memristor crossbars were fabricated at 40 nm half-pitch, using nanoimprint lithography on the same substrate with Si metal-oxide-semiconductor field effect transistor (MOS FET) arrays to form fully integrated hybrid memory resistor (memristor)/transistor circuits. The digitally configured memristor crossbars were used to perform logic functions, to serve as a routing fabric for interconnecting the FETs and as the target for storing information. As an illustrative demonstration, the compound Boolean logic operation (A AND B) OR (C AND D) was performed with kilohertz frequency inputs, using resistor-based logic in a memristor crossbar with FET inverter/amplifier outputs. By routing the output signal of a logic operation back onto a target memristor inside the array, the crossbar was conditionally configured by setting the state of a nonvolatile switch. Such conditional programming illuminates the way for a variety of self-programmed logic arrays, and for electronic synaptic computing.
Improved modelling and communication of urban risks : case studies from the United Kingdom and South-East Asia (2008)

This paper uses recent studies to demonstrate how modern developments, including remote sensing, 3-D
modelling and responsive surveys, have enabled scientists to better understand urban geological environments
and geohazards and communicate them to the public. These developments are discussed here and illustrated
with three diverse examples from the UK and SE Asia.
Inhibitor of Cysteine Peptidase Does Not Influence the Development of <I>Leishmania mexicana</I> in <I>Lutzomyia longipalpis</I> (2009)

It has been proposed that the natural cysteine peptidase inhibitor ICP of Leishmania mexicana protects the protozoan parasite from insect host proteolytic enzymes, thereby promoting survival. To test this hypothesis, L. mexicana mutants deficient in ICP were evaluated for their ability to develop in the sand fly Lutzomyia longipalpis. No significant differences were found between the wild-type parasites, two independently derived ICP-deficient mutants, or mutants overexpressing ICP; all lines developed similarly in the sand fly midgut and produced heavy late-stage infections. In addition, recombinant L. mexicana ICP did not inhibit peptidase activity of the midgut extracts in vitro. We conclude that ICP has no major role in promoting survival of L. mexicana in the vectorial part of its life cycle in L. longipalpis.
Sumatriptan and episodic pain syndromes other than migraine (1996)

Roberts-Thomson, Iana; Argyrides, Johna; Pannall, Petera; Frewin, Derekb Author Information
Real time, single-cell characterization of basophilic exocytosis through carbon-fiber microelectrode amperometry (CFMA) (42.1) (2009)

Abstract Histamine released by previously sensitized basophils plays a crucial role in inflammation and immediate hypersensitivity reactions. Whereas ensemble-based immunohistochemical assays characterize the average release profile of cell populations, differences among individual basophils or basophil sub-populations remain largely unexplored based on technological limitations. Previous work in our lab has used microelectrochemical techniques to measure real time quantal release from single cells isolated from separate platelet and mast cell populations. Herein we report the use of carbon-fiber microelectrodes to measure the concentration and time course of single-cell histamine secretion by primary culture basophils in response to varying physiological and electrical stimuli. Future work will utilize CFMA and the patch clamp technique to probe single-cell degranulation in a polydimethylsiloxane (PDMS) microfluidic chip model of graduated complexity.
The Benefit of Using Tag-Based Profiles (2007)

Collaborative tagging, i.e. the process of assigning metadata in the form of keywords to shared content by many users, has emerged as an important way to provide information about resources on the Web and elsewhere. Such keywords (tags) are used to enable the organization of information within personal information spaces, such as photo collections, but can also be shared, allowing browsing and searching with the help of tags attached by other users to information resources from the Web. Recent research has shown that such tag distributions stabilize over time and can be used to improve search on the Web. In this paper we are interested in another aspect, namely how they characterize the user and enable personalized recommendations. Using data from a frequently used music search portal, Last.fm, we analyze tag usage and statistics and investigate the use of tag-based user profiles in contrast to conventional user profiles based on song and track usage. We specify recommendation algorithms based on tag user profiles, and explore how collaborative filtering recommendations based on these tag profiles are different from recommendations based on song/track profiles. Finally, we describe a new search-based method, which uses tags to recommend songs interesting to a user, yielding substantially improved results. The paper finishes with a discussion of some future work to further improve tag-based search and recommendation in community Web sites.
Proliferation resistance modeling. (2004)

The National Nuclear Security Administration is developing methods for nonproliferation assessments. A working group on Nonproliferation Assessment Methodology (NPAM) assembled a toolbox of methods for various applications in the nonproliferation arena. One application of this methodology is to the evaluation of the proliferation resistance of Generation IV nuclear energy systems. This paper first summarizes the key results of the NPAM program and then provides results obtained thus far in the ongoing application, which is co-sponsored by the DOE Office of Nuclear Energy Science and Technology. In NPAM, a top-level measure of proliferation resistance for a fuel cycle system is developed from a hierarchy of metrics. The problem is decomposed into: metrics to be computed, barriers to proliferation, and a finite set of threats. The analyst models the process undertaken by the proliferant to overcome barriers to proliferation and evaluates the outcomes. In addition to proliferation resistance (PR) evaluation, the application also addresses physical protection (PP) evaluation against sabotage and theft. The Generation IV goal for future nuclear energy systems is to assure that they are very unattractive and the least desirable route for diversion or theft of weapons-usable materials, and provide increased physical protection against terrorism. An Expert Group, addressingmore » this application, has identified six high-level measures for the PR goals (six measures have also been identified for the PP goals). Combined together, the complete set of measures provides information for program policy makers and system designers to compare specific system design features and integral system characteristics and to make choices among alternative options. The Group has developed a framework for a phased evaluation approach to analyzing PR and PP of system characteristics and to quantifying metrics and measures. This approach allows evaluations to become more detailed and representative as system design progresses. Three sequential levels of detail are anticipated: qualitative, semi-quantitative and quantitative evaluation of the metrics and measures.« less
High-Temperature Superconductivity in a Single Copper-Oxygen Plane (2009)

The question of how thin cuprate layers can be while still retaining high-temperature superconductivity (HTS) has been challenging to address, in part because experimental studies require the synthesis of near-perfect ultrathin HTS layers and ways to profile the superconducting properties such as the critical temperature and the superfluid density across interfaces with atomic resolution. We used atomic-layer molecular beam epitaxy to synthesize bilayers of a cuprate metal (La(1.65)Sr(0.45)CuO4) and a cuprate insulator (La2CuO4) in which each layer is just three unit cells thick. We selectively doped layers with isovalent Zn atoms, which suppress superconductivity and act as markers, to show that this interface HTS occurs within a single CuO2 plane. This approach may also be useful in fabricating HTS devices.