gebhart/patrepeval huggingface dataset:
A linear programming based heuristic algorithm for bandwidth packing problem with scheduling (2019)

In this article, we consider a variant of the bandwidth packing problem, in which some demands need to be scheduled within given time windows. The emergence of cloud services has introduced a new challenge to the bandwidth packing problem. For example, a typical cloud service network consists of multiple data centres (DCs), and a huge amount of data must be exchanged between DCs to ensure the integrity of the data. This operation is not necessarily real-time, which allows network operators to schedule the demands over time. Motivated by a real-life network service provider in South Korea, we developed a practical heuristic algorithm for the problem. The algorithm utilises an open source linear programming solver. The performance of the proposed algorithm was assessed on the real-life telecommunication network in South Korea. The computational results showed that the proposed approach can provide near-optimal solutions within a short time.
Investigation of the Physicochemical Properties of Pyrrolidinium-Based Mixed Plastic Crystal Electrolytes (2023)

Organic ionic plastic crystals (OIPCs) are promising candidates for solid-state electrolyte materials for energy storage applications. Mixing of two OIPCs to produce new solid-state electrolyte materials is proposed to be a route to increasing defects/disorder in the materials, which may in turn promote ion transport. In this work, the thermal phase behavior and transport properties of two different pyrrolidinium-based binary OIPC mixtures were investigated. The most promising was the mixture of N,N-diethylpyrrolidinium bis(fluorosulfonyl)imide ([C2epyr][FSI]) and N-isopropyl-N-methylpyrrolidinium bis(fluorosulfonyl)imide ([C(i3)mpyr][FSI]), studied across the entire composition range, where the 10 mol % [C(i3)mpyr][FSI] mixture showed the highest ionic conductivity of 2 × 10–5 S cm–1 at 30 °C, consistent with the increased ion dynamics indicated by solid-state NMR analysis. Synchrotron XRD analysis revealed that the addition of 10 mol % [C(i3)mpyr][FSI] to [C2epyr][FSI] contributed to lattice expansion, hinting at increased defect volume and/or rotational disorder that assists with improved transport properties. Additionally, 10 mol % LiFSI was added to the chosen binary OIPC mixtures to investigate their potential use as electrolytes. The 10 mol % binary mixture with 10 mol % LiFSI showed the highest ionic conductivity (1.8 × 10–3 S cm–1 at 30 °C), while PFG analysis showed that the [FSI]− anions in the 10 mol % mixture with Li-salt have the highest diffusivity compared to other binary mixtures with Li-salt. Analysis of the structure-dynamics of mixed pyrrolidinium-based binary OIPCs provides insights into this scarcely explored strategy for improving the physicochemical properties of plastic crystal systems and toward the development of improved solid-state electrolytes for battery applications.
Isolation of tridecaptins A, B and C. Studies on antibiotics from the genus Bacillus. XXIII. (1978)

Three new antibiotics, tridecaptins A, B and C, were isolated from culture broths of strains of Bacillus polymyxa AR-110, B-2 and E-23, respectively. All are acyl tridecapeptides differing from each other in the fatty acid components and amino acid residues. They are weakly active against Gram-negative and Gram-positive bacteria in vitro and in vivo.
Insulation science (2012)

Energy efficiency has been recognized as the most effective near-term means to meet the energy and environmental crisis we face today. In the USA, buildings are the largest energy-consumption sector of the economy. Residential and commercial buildings combined consume over 40% of the primary energy and over two-thirds of the total electricity [1]. Heating and cooling are the largest portions of this. Demonstration homes have shown that the heating consumption can be reduced by as much as 90% by the proper application of very thick thermal insulation in the walls, roof, and windows [2]. One challenge is the development of very thin economical insulation materials that provide the same performance.
Ambiente de trabajo: Una evaluación de riesgos psicosociales y carga de trabajo mental en agentes de tránsito (2017)

COPSOQ, y WHOQOL/Bref.
Enhancing the Photoelectric Effect with a Potential-Programmed Molecular Rectifier (2012)

Dendrimer-based electron rectifiers were applied to photoconducting devices. A remarkable enhancement of the photocurrent response was observed when a zinc porphyrin as the photosensitizer was embedded in the dendritic phenylazomethine (DPA) architecture. The dendrimer-based sensitizer exhibited a 20-fold higher current response than the non-dendritic zinc porphyrin. In sharp contrast, a similar application of the dendrimer with poly(vinylcarbazole) as the electron donor resulted in a decreased response. This is consistent with the idea that the DPA facilitates electron transfer from the core to its periphery along a potential gradient, as predicted by density functional theory calculations.
Conducting phenylenevinylene blends as electrode materials in LC amperometric detection (1997)

Abstract A novel amperometric electrode based on a conducting polymer is presented and its properties are compared with those of a glassy carbon electrode. The electrode material was made by mixing 2,5‐dimethoxy‐1,4‐bis[2‐(3,4,5‐trimethoxy‐phenyl)ethenyl]benzene with iodine and polycarbonate. The blend was coated on a glassy carbon electrode by evaporation from a chloroform solution. Catecholamines were used as test substances in LC and FIA measurements. They were oxidized at a potential of +0.7 V (vs. SCE). The electrode exhibited a linear response for injected concentrations from 2.5 × 10 −6 M to 2.5 × 10 −3 M. It had a response time of 1.2 s and a coulometric efficiency of 0.74% at a linear flow rate of 1 mL/min. The electrode material is stable for several months under normal operating conditions. Hydrodynamic voltammograms showed E 1/2 values shifted by approximately 100 mV as compared to glassy carbon. The novel redox‐conducting coating is proposed as an alternative material for the development of enzyme electrodes and chemically modified electrodes.
1,3‐Dipolare Addition von 2‐Benzonitrilio‐2‐propanid an 7‐Methylthieno[2,3‐c]pyridin‐1,1‐dioxid und Folgereaktionen (1983)

1,3‐Dipolar Addition of 2‐Benzonitrilio‐2‐propanid to 7‐Methylthieno[2,3‐ c ]pyridine 1,1‐Dioxide and Subsequent Reactions The addition of dipole 2 , generated photochemically from 2,2‐dimethyl‐3‐phenyl‐2 H ‐azirine ( 1 ), to 7‐methylthieno[2,3‐ c ]pyridine 1,1‐dioxide yields the pyrroline derivative 4 as a major product and regioisomer 5 in low yield. Compound 4 can be transformed into the pyrrolidine derivative 11 by ring opening, loss of SO 2 and hydrogenation. Bromopyrroline derivative 14 gives either by dehydrohalogenation compound 18 or, by substitution, nitrile 17 or ethoxy derivative 19 . Substitution of 14 and ring opening yields methoxypyrrole derivative 20 , which gives access to the unstable hydroxypyrrole and hydroxypyrrolidine derivative 28 resp. 30 . The vinylsulfone 18 is the starting material for addition‐ring‐cleavage reactions. Oxidation of pyrroline derivative 4 gives epoxy‐substituted N ‐oxide 39 and di‐ N ‐oxide 40 ; and oxidative transformation of pyrrolidine derivative 11 yields the (hydroxymethyl)pyridylpyrrolidine derivative 45 .
Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097 (2015)

The tumor suppressor p53 is a key regulator of apoptosis and functions upstream in the apoptotic cascade by both indirectly and directly regulating Bcl-2 family proteins. In cells expressing wild-type (WT) p53, the HDM2 protein binds to p53 and blocks its activity. Inhibition of HDM2:p53 interaction activates p53 and causes apoptosis or cell-cycle arrest. Here, we investigated the ability of the novel HDM2 inhibitor CGM097 to potently and selectively kill WT p53-expressing AML cells. The antileukemic effects of CGM097 were studied using cell-based proliferation assays (human AML cell lines, primary AML patient cells, and normal bone marrow samples), apoptosis, and cell-cycle assays, ELISA, immunoblotting, and an AML patient-derived in vivo mouse model. CGM097 potently and selectively inhibited the proliferation of human AML cell lines and the majority of primary AML cells expressing WT p53, but not mutant p53, in a target-specific manner. Several patient samples that harbored mutant p53 were comparatively unresponsive to CGM097. Synergy was observed when CGM097 was combined with FLT3 inhibition against oncogenic FLT3-expressing cells cultured both in the absence as well as the presence of cytoprotective stromal-secreted cytokines, as well as when combined with MEK inhibition in cells with activated MAPK signaling. Finally, CGM097 was effective in reducing leukemia burden in vivo. These data suggest that CGM097 is a promising treatment for AML characterized as harboring WT p53 as a single agent, as well as in combination with other therapies targeting oncogene-activated pathways that drive AML.
Effects of water in water/phenol mixtures on liquefaction of Japanese beech as treated under subcritical conditions (2012)

Abstract Japanese beech ( Fagus crenata ) has been liquefied by water-added subcritical phenol without a catalyst in a batch-type reaction vessel. The effect of water/phenol ratio was studied under conditions of various treatment times. The fractions soluble in phenol/water as well as the insoluble residues were characterized. Liquefaction kinetics was investigated assuming the validity of the first-order reaction rate law. The degree of phenolation was increased with increasing treatment times and water content in phenol/water solvent. Treatment at 270°C under 3.1 MPa pressure for 10 min with a water/phenol ratio of 25:75 gave the best liquefaction result. Various oligosaccharides derived from cellulose and hemicelluloses were found to be hydrolyzed and solubilized in the water-soluble portion.
Allocation of ATP to synthesis of cells and hydrolytic enzymes in cellulolytic fermentative microorganisms: Bioenergetics, kinetics, and bioprocessing (1998)

Under anaerobic, carbon limited conditions, celluloytic fermentative microorganisms face a metabolic choice with respect to the allocation of relatively scarce ATP: to invest it in cells or in hydrolytic enzymes. A model is proposed that defines an allocation parameter reflecting the fractional expenditure of ATP on cell synthesis relative to the total ATP available (gross ATP synthesized less maintenance). This parameter is then incorporated into an ATP-centered model of anaerobic cellulose fermentation based on the ethanol fermentation of yeast and the cellulase system of Trichoderma reesei. Results indicate that high processing rates are possible via a consolidated bioprocessing strategy, especially at high cellulase specific activities, and that cell/cellulase allocation represents an interesting system in which to study, and perhaps exploit, microbial evolution and metabolic control.
Two-Dimensional Analytical Solution of Ideal Perforation Flow (2010)

Abstract Core flow efficiency (CFE) is defined to quantitatively evaluate the flow performance of single-shot perforation. To calculate CFE, the flow rate of the ideal perforation flow in the core target is needed. The ideal flow rate is typically calculated with numerical simulators, but the computation may be time-consuming and costly. This paper presents the two-dimensional analytical solution of the steady state flow model (mass conservation equation) for the ideal single-shot perforation in a cylindrical core sample. The separation of variable method is used to solve the partial differential equation of the flow model. Pressure and velocity distributions in (r, z) space are obtained, as well as the flow rate distribution along the perforation tunnel. The accuracy and convergence of the analytical solution for the ideal single-shot perforation flow are investigated and compared with those of the numerical solution of the commercial software ANSYS FLUENT. The analytical solution for the governing equation of the ideal perforation flow is composed of the infinite number of Bessel functions. To compute the CFE by making use of this analytical solution, the analytical solution is approximated with a limited number of Bessel functions. The approximated analytical solution is analyzed and compared with the numerical solutions from ANSYS FLUENT. Further, the axial, radial, and radial-axial flow geometries of the ideal shingle-shot perforation are characterized with their approximated analytical solutions. Interactions between the boundary condition, perforation parameters, and core parameters are investigated for these flow geometries. The analysis results show that: 1) the analytical solution has no grid effects; 2) the boundary condition of the perforated core is the dominant factor to the ideal flow rate of the perforated core; 3) the penetration depth and anisotropic permeability are the significant factors to the flow performance of the perforated core.
Limitation of in-situ arthroscopic fixation for stable juvenile osteochondritis dissecans in the knee (2018)

Level IV, case series.
[Incidence of fetal chromosomal aberration in prenatal cytogenetic examination]. (1991)

One thousand forty-seven fetal samples were obtained from women who received the prenatal cytogenetic examination for different reasons. In this study, the incidence of fetal chromosomal aberration related to each reason was analyzed. The incidence of de novo chromosomal aberration in the fetuses of the higher maternal age group was 1.5% (8/525: 4 cases of 21-trisomy, 2 cases of 18-trisomy and 2 cases of 47,XXY). The incidence in the group of women who had borne (a) chromosomally abnormal child(ren) was 0.5% (1/202). There was no repeat of 21-trisomy, 18-trisomy or 13-trisomy in this study. The incidence in the group of women who had ultrasonographic abnormalities was 16.9% (26/154). In this study, abnormal amniotic fluid volume, intrauterine growth retardation, malformation, hydrops fetalis, intestinal obstruction, omphalocele, single cord artery and cerebellar hypoplasia were related to chromosomal aberrations. The incidence in the group of women whose husband or herself was cytogenetically abnormal was 40.0% (26/65). This high value indicated that parental translocation and inversion are easily transmitted to their offspring.
Symmetric Vertical Parallel Plate Capacitors for On-Chip RF Circuits in 65-nm SOI Technology (2007)

This letter presents symmetric vertical parallel plate (VPP) capacitors in 65-nm silicon-on-insulator CMOS technology. Three VPP capacitors with different metal layer options are examined with respect to effective capacitance density and -factor. An effective capacitance of 2.18 and a -factor of 23.2 at 1 GHz are obtained from a 1x + 2x (M1-M6) metal layer configuration's pre-de-embedding measurement. VPP capacitor symmetry, mismatch, leakage current density, vertical scalability, and variation characteristics from a 300-mm wafer are discussed.
Small Cell Neuroendocrine Carcinoma of the Esophagus Producing Parathyroid Hormone-related Peptide with Humoral Hypercalcemia (2014)

症例は79歳，男性．転移性肝腫瘍の精査中に意識障害のため入院となった．高Ca血症と肝不全の進行あり，全身状態が悪化し入院8日目に死亡した．剖検では食道小細胞癌の多発肝転移の診断となり，副甲状腺ホルモン関連タンパク（PTHrP）に対する免疫組織化学染色で，腫瘍細胞が陽性となった．食道小細胞癌には様々な腫瘍随伴症候群が報告されているが，PTHrP産生による高Ca血症の報告は本症例で4例目と稀であり，今回報告した．
Regional Variability of Stretch Reflex Amplitude in the Cat Medial Gastrocnemius Muscle During a Postural Task (1997)

The relationship between local fibre stretch velocity (mechanical input) and the corresponding local reflex electromyographic (EMG) amplitude (a measure of the neural output) was assessed to determine the contribution of muscle spindle feedback in postural control. We hypothesized that traditionally measured input variables (e.g., the velocity of an external movement or whole muscle velocity) may not accurately represent the mechanical input to the muscle spindles, especially when the background forces are small. Three cats were trained to stand on pedestals while ankle rotations were applied to the left hindlimb. EMG and fiber movement in both proximal and distal regions of the muscle were recorded in addition to muscle length and tendon force. We found that local muscle velocity was correlated poorly with whole muscle velocity, demonstrating that internal and external muscle movements are often dissimilar, particularly during tasks that involve modest levels of muscle activation. Local EMG reflex amplitudes were correlated well with the corresponding local fiber stretch velocities (R values ranging from 0.5 to 0.8) but not with muscle stretch velocity. The lack of crossed correlations between fiber stretch velocities and reflex EMG amplitudes measured in proximal versus distal regions of the muscle suggests the presence of a local reflex component. It is concluded that changes in local muscle fiber length represent the mechanical input to spindles better than changes in the total muscle length. Additionally, spindles have a specific role in the reflex activation of nearby muscle fibers.
Homologous Pairing Promoted by Ustilago RecI Protein (1984)

Genetic recombination occurs by breakage and reunion of DNA. The recombining DNA molecules are joined through a region of heteroduplex, a molecular splice in which one strand from each parental DNA molecule pairs with its complement. The process leading to formation of the heteroduplex joint has been envisioned as a series of steps whereby DNA molecules are brought into homologous register and strand exchange is begun (Holliday 1964; Meselson and Rad-ding 1975; Szostak et al. 1983). Until a short while ago, suitable assays were not available for biochemical measurements of genetic recombination. For this reason, explanations of heteroduplex formation during recombination relied in large part on genetical observations. Recently, a much clearer picture of the molecular events surrounding heteroduplex formation has emerged (Radding 1982). With the cloning of the recA gene (McEntee and Epstein 1977; Ogawa et al. 1979; Sancar and Rupp 1979) and the purification of its product, the...
Micro-jet printing of polymers for electronics manufacturing (2002)

Ink-jet/micro-jet printing methods are being developed for direct writing of a variety of materials for electronics and optoelectronics manufacturing. Advantages offered by this approach for micro-element fabrication and adhesive joining include precise volumetric control of dispensed material, data-driven flexibility, low cost, high speed and low environmental impact. Custom thermo-setting and thermoplastic systems have been developed for the printing of optical interconnects, dielectric elements and coatings, adhesives and thick film resistors, utilizing a drop-on-demand piezoelectric print head operable at temperatures up to 300/spl deg/C. Examples of printing reviewed here are: (a) adhesives for component bonding; (b) dielectrics for overcoating and conformal microelectronics fabrication; (c) thick-film resistors; (d) micro-optical components; and (e) polymers filled with oxides and fluorescent materials. Manufacturing applications potentially addressable to advantage by this method include flip-chip die attach, chip-scale microelectronics packaging, underfilling and overcoating, along with fabrication of passive devices, disk drive heads and flat panel displays.
Erratum to “How to treat left ventricular thrombi- Warfarin or direct oral anti-coagulants?” [Am. Heart J. Plus Cardiol. Res. Pract. 13 (January 2022) 100075] (2022)

[This corrects the article DOI: 10.1016/j.ahjo.2021.100075.].
Polyester polyols: Synthesis and characterization of diethylene glycol terephthalate oligomers (2003)

Abstract The composition of polyester polyols derived from terephthalic acid (TPA) and diethylene glycol (DEG) was examined. The synthesis of individual oligomers 1 , n is described. The compounds were characterized with 1 H and 13 C NMR, mass spectrometry, and elemental analyses. The resonance signals arising from aromatic protons in 1 , n = 1–3 were identified in 1 H NMR spectra of TPA‐DEG condensates. From 1 H NMR studies and chromatographic separation, it was concluded that the condensation of TPA and DEG in a 1:2 molar ratio results in a mixture of linear oligomers 1 with the average ñ varying from 1.1 to 2.2, and containing about 2% of cyclic oligomer 2 . © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 1114–1123, 2003
Downregulation of Protein Phosphatase 2A Carboxyl Methylation and Methyltransferase May Contribute to Alzheimer Disease Pathogenesis (2004)

ABalphaC, a major protein phosphatase 2A (PP2A) heterotrimeric enzyme, binds to and regulates the microtubule cytoskeleton and tau. We have shown that ABalphaC protein expression levels are selectively reduced in Alzheimer disease (AD). Notably, the carboxyl methylation of PP2A catalytic subunit (PP2A(C)) is critically required for ABalphaC holoenzyme assembly, and catalyzed by a specific methyltransferase (PPMT). Here, we provide the first analysis of human PPMT and methylated PP2A(C) in brain regions from AD, non-AD demented, and aged control autopsy cases. Immunoblotting analyses revealed that PPMT protein expression and PP2A(C) methylation levels were quantitatively decreased in AD-affected brain regions. Immunohistochemical studies showed that PPMT was abundant in neurons throughout the cortex in normal control and non-AD demented cases. However, in AD, there was a regional loss of PPMT immunoreactivity that closely paralleled the severity of tau pathology, but not amyloid plaque burden. We propose that the deregulation of PPMT and PP2A methylation/demethylation cycles contributes to AD pathogenesis, by inducing changes in PP2A heteromultimeric composition and substrate specificity. In turn, PP2A dysfunction compromises the mechanisms that control tau, neuronal plasticity, and survival.
Photochemical Rearrangement of N-Chlorolactams: A Route to N-Heterocycles through Concerted Ring Contraction (2010)

We report a novel ring contraction allowing the direct conversion of N-chlorolactams to their corresponding ring-contraction N-heterocycles upon photolysis. Results show that the rearrangement occurs with a variety of N-chlorolactams and that the greater the substitution at the migrating carbon, the greater the yield of product. Importantly, stereochemistry at the migrating carbon is conserved in the product. Rearranged products were isolated as their methyl carbamates in yields varying from 17% to 58%, with the major side product being the recyclable parent lactam.
6α‐ and 6β‐methyl steroids in the 19‐nor series (1971)

Abstract The dehydration‐epimerization reaction applied to a 5α‐hydroxy‐6β‐methyl‐3‐oxo‐19‐nor‐steroid, under acid conditions, leads to a mixture of the 6α‐methyl‐3‐oxo‐Δ 4 ‐19‐nor‐steroid and its 6β‐epimer. This is in contrast to the normal steroid series, in which exclusively the 6α‐methyl epimer is formed. A complete conversion to the 6α‐methyl compounds can be achieved by alkaline hydrolysis of the corresponding 3‐acetoxy‐6‐methyl‐Δ 3,5 compounds. Several 6‐methyl‐3‐oxo‐Δ 4 compounds in the estrene and 19‐nor‐pregnene series have been converted to their 3‐desoxo derivatives.
Initial Combination Therapy With Canagliflozin Plus Metformin Versus Each Component as Monotherapy for Drug-Naïve Type 2 Diabetes (2016)

Initial therapy with CANA plus MET was more effective and generally well tolerated versus each monotherapy in drug-naïve type 2 diabetes. CANA monotherapy demonstrated noninferior HbA1c lowering versus MET.