gebhart/patrepeval huggingface dataset:
A biomechanical model of the pelvic cavity: first steps (2006)

The surgical treatments of genital prolapsus are still empirical and poorly valued. We plan to achieve a method for the objective assessment of the troubles of the pelvic statics and of the various surgical strategies. The methodology considers 3 axes: building a 3D mechanical model of the pelvic cavity, mechanical characterization of the concerned organic tissues, in-vivo measurement of the intravaginal pressures. The MRI images are acquired according 3 orientations (sagittal, axial and coronal); the organs (bladder, vagina and rectum) are manually outlined and their 3D shape is then rebuilt. Uniaxial tensile tests are initially developed on animal samples before being applied to peroperative human samples. In-vivo measurements of the intravaginal pressures are made thanks to a set of 8 strain gauges specially designed. We show results obtained on 2 patients with a different rank of prolapsus. These first steps will be continued by a more detailed geometry of the organs and a characterization of healthy tissues. Dynamic behaviour of the mechanical stresses will also be investigated.
Neural Network Approach to Forecast Hourly Intense Rainfall Using GNSS Precipitable Water Vapor and Meteorological Sensors (2019)

This work presents a methodology for the short-term forecast of intense rainfall based on a neural network and the integration of Global Navigation and Positioning System (GNSS) and meteorological data. Precipitable water vapor (PWV) derived from GNSS is combined with surface pressure, surface temperature and relative humidity obtained continuously from a ground-based meteorological station. Five years of GNSS data from one station in Lisbon, Portugal, are processed. Data for precipitation forecast are also collected from the meteorological station. Spaceborne Spinning Enhanced Visible and Infrared Imager (SEVIRI) data of cloud top measurements are also gathered, providing collocated information on an hourly basis. In previous studies it was found that the time-varying PWV is correlated with rainfall and can be used to detected heavy rain. However, a significant number of false positives were found, meaning that the evolution of PWV does not contain enough information to infer future rain. In this work, a nonlinear autoregressive exogenous neural network model (NARX) is used to process the GNSS and meteorological data to forecast the hourly precipitation. The proposed methodology improves the detection of intense rainfall events and reduces the number of false positives, with a good classification score varying from 63% up to 72% and a false positive rate of 36% down to 21%, for the tested years in the dataset. A score of 64% for intense rain events classification with 22% false positive rate is obtained for the most recent years. The method also achieves an almost 100% hit rate for the rain vs no rain detection, with close to no false alarms.
ChemInform Abstract: Novel β‐Lactamase Inhibitory and Antibacterial 6‐Spiroepoxypenicillins. (1988)

Abstract Reaction of the diazopenicillanates (I) with oxalyl chloride (II), followed by hydrolysis and esterification, yields the spiro epoxides (IV) and (V).
Laparoscopic Port Sites do not Require Fascial Closure when Nonbladed Trocars are Used (2000)

The development of nonbladed obturators with integrated stability sleeves allows for creation of a muscle-splitting dilated laparoscopic port site with minimal abdominal wall defects after removal of trocar sleeves. Our objective was to determine the safety of using nonbladed obturators and not closing laparoscopic fascial port sites. Seventy patients underwent various laparoscopic procedures including the following: seven laparoscopic Roux en Y gastric bypasses, 21 laparoscopic cholecystectomies, 23 laparoscopic hernia repairs, 10 laparoscopic Nissen fundoplications, two laparoscopic appendectomies, two laparoscopic liver biopsies, one laparoscopic common bile duct exploration, one laparoscopic jejunal resection, one laparoscopic low anterior resection, one laparoscopic splenectomy, and one bedside diagnostic laparoscopy. A total of 180 laparoscopic port sites did not undergo fascial closure involving 110 10- to 12-mm ports. One hundred eighty nonbladed trocars were inserted without complication during laparoscopic surgery. In all cases the nonbladed obturator did not cause bleeding or injure viscera. Upon removal of large laparoscopic ports, the fascial defect was less than 6 to 8 mm, and the muscles of the abdominal wall covered the port site defect. The anterior fascial defect did not line up with the posterior fascial defect after removal of CO2 insufflation. No patients have developed ventral incisional hernias in the postoperative period (median follow-up of 11 months). We conclude that the use of nonbladed laparoscopic trocars is a safe technique with the ability to visualize dissection through the abdominal wall layers to create the smallest port dissection without bleeding or cutting muscle fibers. The ability to split the abdominal wall musculature allows the surgeon to forego closure of the small fascial defect.
C/EBPβ Induces Chromatin Opening at a Cell-Type-Specific Enhancer (2008)

We have used the chicken mim-1 gene as a model to study the mechanisms by which transcription factors gain initial access to their target sites in compacted chromatin. The expression of mim-1 is restricted to the myelomonocytic lineage of the hematopoietic system where it is regulated synergistically by the Myb and CCAAT/enhancer binding protein (C/EBP) factors. Myb and C/EBPbeta cooperate at two distinct cis elements of mim-1, the promoter and a cell-type-specific enhancer, both of which are associated with DNase I hypersensitive sites in myelomonocytic cells but not in mim-1-nonexpressing cells. Previous work has shown that ectopic expression of Myb and C/EBPbeta activates the endogenous mim-1 gene in a nonhematopoietic cell type (fibroblasts), where the gene is normally completely silent. Here, we investigated the molecular details of this finding and show that the activation of mim-1 occurs by two independent mechanisms. In the absence of Myb, C/EBPbeta triggers the initial steps of chromatin opening at the mim-1 enhancer without inducing transcription of the gene. mim-1 transcription occurs only in the presence of Myb and is associated with chromatin opening at the promoter. Our work identifies a novel function for C/EBPbeta in the initial steps of a localized chromatin opening at a specific, physiologically relevant target region.
At-line boar taint classification by means of Rapid Evaporative Ionisation Mass Spectrometry (REIMS) (2019)

Increasing awareness of animal welfare has led to a European incentive to ban the surgical castration of piglets. A valid alternative for castration is the rearing of entire male pigs, but this allows the (re)occurrence of boar taint, an off-odour in meat from entire boars (1). Hence, due to adverse consumer reactions to pork with boar taint, the rearing of entire boars requires valid boar taint mitigation strategies. However, the introduction of Rapid Evaporative Ionisation MS (REIMS) offers compelling perspectives for the rapid as well as accurate at-line detection of boar taint by significantly reducing analysis time and workload, yet enhancing research output and efficiency (2). In this study, REIMS was used as a direct analysis technique to train predictive models for identification of boar taint above the odour threshold (based on sensory (soldering iron method) as well as chemical analysis (UHPLC-HRMS analysis of indole, skatole and androstenone levels) 3. Adipose tissue was sampled using a prototype bipolar handheld sampling device connected directly to a Xevo G2-XS Q-TOF system equipped with REIMS source (Fig. 1). The results demonstrate that untargeted mass spectrometric profiling in negative ionisation mode enables the construction of predictive models using LiveID, AMX and Simca (Q2 = 0.547, R2Y = 0.652 and p = 0) for the classification of carcasses according to boar taint status based on alterations in lipid profiles. As REIMS eliminates sample pre-treatment with analysis taking < 10 seconds, it offers significant potential as the first technique enabling accurate in-situ detection of boar taint. REIMS is a promising and highly innovative tool for several types of food quality and safety applications, furthermore allowing us to move state-of-the-art equipment and applications from bench to production site. Acknowledgments: This research was partly funded by the Flemish Government, department of animal welfare (LNE/STG/DWZ/16/11). References: [1] K. Verplanken, Ghent University PhD dissertation, (2018) 1-15. [2] K. Verplanken et al., Talanta, 169 (2017) 30–36. [3] K. Bekaert et al., Journal of Chromatography A, 1239 (2012) 49-55.
Abstract 19881: Impact of Radiofrequency Application Time and Power on Lesion Volume Created by a Novel Heated Saline Enhanced Radiofrequency Needle-tip Catheter: Evidence From an MRI Lesion Validation Study (2016)

Purpose: This study was conducted to assess controllability of lesion creation in left ventricular myocardium using a novel heated saline enhanced radiofrequency (RF) needle-tip catheter. Methods: Six normal dogs underwent catheter ablation using this novel catheter (closed-end 25-gauge needle [penetration depth 6 mm], 24 radial side holes for injection of heated saline). Ablative lesions were created using different power and RF application times (21, 33, 40, 45W; application of 25, 50, 60, 75sec.; irrigation saline 60°C with 10mL/min flow). Needle penetration was assessed by intracardiac echocardiography (ICE). Hearts were explanted one week after ablation and evaluated using postmortem 3.0T-MR imaging (FSPGR sequences, 1mm slice interval). Gross pathologic and histologic characteristics of lesions were examined. Lesion volume was measured using MR images and compared to volumes obtained in gross pathology. Results: In total, 29 lesions (5 lesions with 21W/25sec, 5 with 21W/75sec, 5 with 33W/50sec, 4 with 40W/60sec, 5 with 45W/25sec and 5 with 45W/75sec) were assessed. No steam pop, perforation and lethal arrhythmia events were observed during RF application. All lesions were successfully identified on MR images. Out of the 29 lesions, 23 lesions (79.3%) were transmural. Lesion volume data are summarized in Figure. Time Δlesion volume was 50.2mm 3 /sec with 21W, 37.3mm 3 /sec with 45W and power Δlesion volume was 74.7mm 3 /W with 25sec, 47.7mm 3 /W with 75 sec. Spearman rank correlation test showed positive correlations between gross pathologic lesion volume, RF application time and MRI lesion volume (r=0.833; p Conclusions: This novel catheter created LV lesions correlates with RF application time. MR lesion size is dependent on both time and power, although, unlike other ablation tools ablation time is more important than power.
Displaying the Driving State of Automated Vehicles to Other Road Users: An International, Virtual Reality-Based Study as a First Step for the Harmonized Regulations of Novel Signaling Devices (2020)

Additional signaling devices for highly automated vehicles (AVs) that can communicate their driving state to other road users can simplify the integration process in existing road traffic. This paper presents the results of an international, virtual reality-based study conducted in China, South Korea and the USA in which subjects assume the role of a pedestrian and are placed in direct encounter situations with an AV in a parking lot. A novel communication interface consisting of three displays is attached to the AV&#x2019;s front and used to show additional information about its driving state. In total, three encounter scenarios are investigated: the AV approaches from the left, front and right outside of the pedestrian&#x2019;s line of sight. The influence of different symbol types on the subject&#x2019;s moving behavior, recognition of intention and perceived safety is investigated. The results show that additional signals ensure a better perception of the AV&#x2019;s intention and increase the perceived safety. The moving behavior of subjects is significantly changed when additional signals are used during driving tasks compared to the same tasks without such signals. The change of moving behaviour is similar in encounter situations where the AV approaches from the left and front but differs in encounter situations from the right. These results could equally be proven for all nationalities, which shows that a uniform, international solution for additional signaling devices of highly automated vehicles is possible.
The Use of Structural Linguistic Methods for Processing of Vector Geo-Information Data in the SXF Format (2004)

Possibility for the use of structural linguistic methods based on the formal meta-grammar instruments for processing the vector geo-information data in the SXF format has been studied.
Infrared emission spectra from a heterogeneous catalyst system in reaction conditions 1: Description of the microreactor assembly (1980)

The design and construction of a microreactor with an IR transmitting window are described. The microreactor can be used to study heterogeneously catalyzed gas phase reactions in the l00-600 degrees C temperature range by analyzing the emitted IR radiation with the aid of a Fourier transform infrared spectrometer. The reactor feed can be prepared so that the reaction conditions correspond to a practical, heterogeneously catalyzed, gas phase reaction system. Product stream monitoring can be carried out to determine whether the IR emission spectra obtained originate from a stationary state in the catalytic reaction. Some results obtained with the present microreactor are given.
Nortriterpenoids from the Fruiting Bodies of the Mushroom Ganoderma resinaceum (2017)

<i>Ganoderma resinaceum</i> is usually used as ethnomedicine for immune-regulation, hyperglycemia, and liver disease. To date, only a few chemical constituents have been reported from <i>G</i>. <i>resinaceum</i>. In this study, fifteen nortriterpenoids including six new nortriterpenoids (<b>1</b>-<b>6</b>) and nine known analogs (<b>7</b>-<b>15</b>), were separated and purified from the fruiting bodies of <i>G</i>. <i>resinaceum</i>. New compounds were identified as lucidone I (<b>1</b>), lucidone J (<b>2</b>), lucidone K (<b>3</b>), lucidone I (<b>4</b>), ganosineniol B (<b>5</b>), and ganosineniol C (<b>6</b>), based on analysis of extensive spectroscopic data (high resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV)). The known compounds were assigned as lucidone A (<b>7</b>), lucidone B (<b>8</b>), lucidone H (<b>9</b>), lucidone E (<b>10</b>), lucidone F (<b>11</b>), lucidone D (<b>12</b>), lucidone C (<b>13</b>), ganoderense F (<b>14</b>), and ganosineniol A (<b>15</b>), by comparing their spectroscopic data with those reported in the literature. Compounds <b>3</b>, <b>4</b>, and <b>7</b>-<b>13</b> were examined for <i>α</i>-glucosidase inhibitory activity and display no significant activity, but the finding may support that the side chain of ganoderma triterpenoids played an important role in <i>α</i>-glucosidase inhibitory activity.
Computational fluid dynamics analysis of the Venturi Dustiness Tester (2017)

Dustiness quantifies the propensity of a finely divided solid to be aerosolized by a prescribed mechanical stimulus. Dustiness is relevant wherever powders are mixed, transferred or handled, and is important in the control of hazardous exposures and the prevention of dust explosions and product loss. Limited quantities of active pharmaceutical powders available for testing led to the development (at University of North Carolina) of a Venturi-driven dustiness tester. The powder is turbulently injected at high speed (<i>Re</i> ~ 2 × 10<sup>4</sup>) into a glass chamber; the aerosol is then gently sampled (<i>Re</i> ~ 2 × 10<sup>3</sup>) through two filters located at the top of the chamber; the dustiness index is the ratio of sampled to injected mass of powder. Injection is activated by suction at an Extraction Port at the top of the chamber; loss of powder during injection compromises the sampled dustiness. The present work analyzes the flow inside the Venturi Dustiness Tester, using an Unsteady Reynolds-Averaged Navier-Stokes formulation with the <i>k-ω</i> Shear Stress Transport turbulence model. The simulation considers single-phase flow, valid for small particles (Stokes number <i>Stk</i> <1). Results show that ~ 24% of fluid-tracers escape the tester before the Sampling Phase begins. Dispersion of the powder during the Injection Phase results in a uniform aerosol inside the tester, even for inhomogeneous injections, satisfying a necessary condition for the accurate evaluation of dustiness. Simulations are also performed under the conditions of reduced Extraction-Port flow; results confirm the importance of high Extraction-Port flow rate (standard operation) for uniform distribution of fluid tracers. Simulations are also performed under the conditions of delayed powder injection; results show that a uniform aerosol is still achieved provided 0.5 s elapses between powder injection and sampling.
Linear Models with Many Cores and CPUs: A Stochastic Atomic Update Scheme (2018)

Linear models are fast to train, apply, and still state of the art for sparse and high dimensional problems. Their computational efficiency makes them difficult to parallelize, with the standard multi-core approaches often diverging after more than 8 cores are added. We propose a Stochastic Atomic Update Scheme (SAUS) for training linear models on many core machines. It is simple to implement, reduces the number of divergent cases, and obtains greater speedups by being able to effectively use an 80-core server.
SUMMARY (SUMMARY TALK AT THE QUARKONIUM PRODUCTION IN NUCLEAR COLLISIONS WORKSHOP). (1998)

This summary is an attempt to overview the wealth of new results and ideas in quarkonium physics presented at the Seattle Workshop. The Workshop in Seattle has shown that the physics of heavy quarkonium continues to develop at a fast pace; moreover, we have every reason to believe that the next year, with RHIC turning on, will mark the beginning of the new exciting era in this field.
Prednisone Treatment for Vestibular Neuritis (2008)

Prednisone therapy might enhance earlier recovery but does not improve the long-term prognosis of VN. The clinical and laboratory parameters in VN are not correlated, and both are required for complete patient evaluation.
Remote critical care consultation: Telehealth projection of clinical specialty expertise (2003)

Remote critical care consultations have been employed between the Naval Hospital in Guam and the Tripler Army Medical Center in Hawaii, a distance of 5300 km. During a 10-week study period there were physician-physician daily consultation rounds for patients in the intensive care unit at the Naval Hospital. Physiological data, video-images and sound were transmitted via a 768 kbit/s frame relay connection, albeit with a 1-3 s delay. During the study there were 87 consultations concerning 25 patients. Preliminary results showed that a broad range of critical care patients could be managed effectively through daily remote critical care consultation. Broader implementation of this strategy may represent a method of making critical care expertise available to front-line military health-care facilities and to remote civilian facilities with limited critical care expertise.
Towards a deep learning approach to brain parcellation (2011)

Establishing correspondences across structural and functional brain images via labeling, or parcellation, is an important and challenging task for clinical neuroscience and cognitive psychology. A limitation with existing approaches is that they i) possess shallow architectures, ii) are based on heuristic manual feature engineering, and iii) assume the validity of the designed feature model. In contrast, we advocate a deep learning approach to automate brain parcellation. We present a novel application of convolutional networks to build discriminative features for brain parcellation, which are automatically learned from labels provided by human experts. Initial validation experiments show promising results for automatic brain parcellation, suggesting that the proposed approach has potential to be an alternative to template or atlas-based parcellation approaches.
GaN/AlGaN waveguide quantum cascade photodetectors at λ ≈ 1.55 μm with enhanced responsivity and ∼40 GHz frequency bandwidth (2013)

We report on ultrafast GaN/AlGaN waveguide quantum cascade detectors with a peak detection wavelength of 1.5 μm. Mesa devices with a size of 7 × 7 and 10 × 10 μm2 have been fabricated with radio-frequency impedance-matched access lines. A strong enhancement of the responsivity is reported by illuminating the waveguide facet, with respect to illumination of the top surface. The room temperature responsivity is estimated to be higher than 9.5 ± 2 and 7.8 ± 2 mA/W, while the −3dB frequency response is extracted to be 42 and 37.4 GHz for 7 × 7 and 10 × 10 μm2 devices, respectively.
The effects of hyperthermia on intracranial pressure, cerebral oxymetry, and cerebral metabolism in traumatic brain injury patients during neurointensive care (2015)

Outcome after traumatic brain injury (TBI) depends on the extent of primary cell death and on the development of secondary brain injury. The general aim of this thesis was to find strategies and quality systems to minimize the extent of secondary insults in neurointensive care (NIC).An established standardized management protocol system, multimodality monitoring and computerized data collection, and analysis systems were used.The Uppsala TBI register was established for regular monitoring of NIC quality indexes. For 2008-2010 the proportion of patients improving during NIC was 60-80%, whereas 10% deteriorated. The percentage of ‘talk and die’ cases was 25 mmHg, cerebral perfusion pressure (CPP) < 50 mmHg and systolic blood pressure < 100 mmHg. Favorable outcome was achieved by 64% of adults.Nurse checklists of secondary insult occurrence were introduced. Evaluation of the use of nursing checklists showed that the nurses documented their assessments in 84-85% of the shifts and duration of monitoring time at insult level was significantly longer when secondary insults were reported regarding ICP, CPP and temperature. The use of nurse checklist was found to be feasible and accurate. A clinical tool to avoid secondary insults related to nursing interventions was developed. Secondary brain insults occurred in about 10% of nursing interventions. There were substantial variations between patients. The risk ratios of developing an ICP insult were 4.7 when baseline ICP ≥ 15 mmHg, 2.9 when ICP amplitude ≥ 6 mmHg and 1.7 when pressure autoregulation ≥ 0.3.Hyperthermia, which is a known frequent secondary insult, was studied. Hyperthermia was most common on Day 7 after admission and 90% of the TBI patients had hyperthermia during the first 10 days at the NIC unit. The effects of hyperthermia on intracranial dynamics (ICP, brain energy metabolism and BtipO2) were small but individual differences were observed. Hyperthermia increased ICP slightly more when temperature increased in the groups with low compliance and impaired pressure autoregulation. Ischemic pattern was never observed in the microdialysis samples. The treatment of hyperthermia may be individualized and guided by multimodality monitoring.
RATE OF MICROSATELLITE INSTABILITY IN YOUNG PATIENTS WITH ADENOMAS: ASSESSMENT OF BETHESDA GUIDELINES TO DETECT HNPCC (2003)

s Submitted for the 68th Annual Scientific Meeting of the American College of Gastroenterology October 10-15, 2003, Baltimore, Maryland: COLON: PDF Only