gebhart/patrepeval huggingface dataset:
CT angiography with volume rendering: advantages and applications in splanchnic vascular imaging. (1996)

The authors compared volume rendering with maximum intensity projection (MIP) and shaded surface display as a technique for generating three-dimensional (3D) images of the vasculature from spiral computed tomography (CT) data sets. In four patients with pathologic splanchnic vasculature, the advantages of volume-rendered display are illustrated for depiction of 3D vascular anatomy, vascular and visceral interrelationships, variant vasculature, tumor encasement, and hepatic tumor localization for presurgical planning.
Exploration of User Groups in VEXUS (2018)

We demonstrate VEXUS, an interactive visualization framework for exploring user data to fulfill tasks such as finding a set of experts, forming discussion groups and analyzing collective behaviors. User data is characterized by a combination of demographics like age and occupation, and actions such as rating a movie, writing a paper or following a medical treatment. The ubiquity of user data requires tools that help explorers, be they specialists or novice users, acquire new insights. VEXUS lets explorers interact with user data via visual primitives and builds an exploration profile to recommend the next exploration steps. VEXUS combines state-of-the-art visualization techniques with appropriate indexing of user data to provide fast and relevant exploration.
Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers (2022)

Extracellular proteolysis is frequently dysregulated in disease and can generate proteoforms with unique neoepitopes not found in healthy tissue. Here, we demonstrate that Abs that selectively recognize a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) could enable more effective and safer treatments for solid tumors. CDCP1 is highly overexpressed in RAS-driven cancers, and its ectodomain is cleaved by extracellular proteases. Biochemical, biophysical, and structural characterization revealed that the 2 cleaved fragments of CDCP1 remain tightly associated with minimal proteolysis-induced conformational change. Using differential phage display, we generated recombinant Abs that are exquisitely selective to cleaved CDCP1 with no detectable binding to the uncleaved form. These Abs potently targeted cleaved CDCP1-expressing cancer cells as an Ab-drug conjugate, an Ab-radionuclide conjugate, and a bispecific T cell engager. In a syngeneic pancreatic tumor model, these cleaved-specific Abs showed tumor-specific localization and antitumor activity with superior safety profiles compared with a pan-CDCP1 approach. Targeting proteolytic neoepitopes could provide an orthogonal "AND" gate for improving the therapeutic index.
Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy (2014)

Cancer radiotherapy (RT) may induce what is referred to as the "abscopal effect," a regression of non-irradiated metastatic lesions distant from the primary tumor site directly subject to irradiation. This clinical response is rare, but has been surmised to be an immune-mediated phenomenon, suggesting that immunotherapy and RT could potentially synergize. Here, we report the outcome of patients with advanced melanoma treated with the immune checkpoint blockade monoclonal antibody antagonist, ipilimumab followed by RT. Patients were selected for enrollment at the National Cancer Institute "Fondazione G.Pascale" through the expanded access program in Italy. Those who experienced disease progression after ipilimumab thus received subsequent RT and were selected for analysis. Among 21 patients, 13 patients (62%) received RT to treat metastases in the brain and 8 received RT directed at extracranial sites. An abscopal response was observed in 11 patients (52%), 9 of whom had partial responses (43%) and 2 had stable disease (10%). The median time from RT to an abscopal response was 1 month (range 1-4). Median overall survival (OS) for all 21 patients was 13 months (range 6-26). Median OS for patients with abscopal responses was extended to 22.4 months (range 2.5-50.3) vs. 8.3 months (range 7.6-9.0) without. A local response to RT was detected in 13 patients (62%) and, of these, 11 patients (85%) had an abscopal response and abscopal effects were only observed among patients exhibiting a local response. These results suggest RT after ipilimumab may lead to abscopal responses in some patients with advanced melanoma correlating with prolonged OS. Our data also suggest that local responses to RT may be predictive of abscopal responses. Further research in larger randomized trials is needed to validate these results.
An optimal topology-transparent scheduling method in multihop packet radio networks (1998)

Many transmission scheduling algorithms have been proposed to maximize the spatial reuse and minimize the time-division multiple-access (TDMA) frame length in multihop packet radio networks. Almost all existing algorithms assume exact network topology information and do not adapt to different traffic requirements. Chlamtac and Farago (1994) proposed a topology-transparent algorithm. Following their approach, but with a different design strategy, we propose another algorithm which is optimal in that it maximizes the minimum throughput. We compare our algorithm with that of Chlamtac and Farago's and with the TDMA algorithm, and find that it gives better performance in terms of minimum throughput and minimum and maximum delay times. Our algorithm requires estimated values of the number of nodes and the maximum nodal degree in the network. However, we show that the performance of our algorithm is insensitive to these design parameters.
Composite techniques for quality analysis in automotive laser welding (2004)

Real-time monitoring of the laser-based applications is becoming a main issue for quality analysis in the steel manufacturing industry. The paper suggests a solution achieving an automated real-time quality inspection in laser welding applications. A composite system composed of soft computing and traditional techniques has been considered for its positive impact on the reduced computation compared with more traditional approaches.
Multiagent Shape Grammar Implementation: Automatically Generating Form Concepts According to a Preference Function (2009)

In new product development, quickly generating many product form concepts that a potential consumer prefers is a challenge. This paper presents the inaugural multiagent shape grammar implementation (MASGI) to automatically generate product form designs according to a preference function that can represent designer or consumer design preference. Additionally, the multiagent system creates a flexible shape grammar implementation that enables modifications to the shape grammar as the form design space changes. The method is composed of three subprocesses: a shape grammar interpreter that implements the shape grammar, an agent system that chooses which shape grammar rules to implement and the parametric design choices according to a preference function, and a preference investigator that determines the preference function, which constraints the automated form design process.
Anti-Purkinje cell cytoplasmic and neuronal nuclear antibodies aid diagnosis of paraneoplastic autoimmune neurological disorders. (1989)

Anti-Purkinje cell cytoplasmic and neuronal nuclear antibodies aid
Recent developments in noradrenergic neurotransmission and its relevance to the mechanism of action of certain antihypertensive agents. (1980)

This report reviews a number of significant developments in the fields of noradrenergic transmission and adrenergic receptors which suggest that, in addition to the classical postsynaptic adrenoceptors, there are also presynaptic adrenoceptors that help modulate the release of norepinephrine (NE) from peripheral as well as central noradrenergic nerve endings during nerve stimulation. In particular, stimulation of presynaptic alpha-adrenoceptors reduces this release of transmitter and the reverse is observed after blockade of these receptors. Clearcut pharmacological differences exist between the postsynaptic alpha 1-adrenoceptors that mediate the responses of certain organs and the presynaptic alpha 2-adrenoceptors that modulate the NE release during nerve stimulation. Therefore, subclassification of alpha-adrenoceptors into alpha 1 and alpha 2 subtypes is warranted but must be considered to be independent of the anatomical location of these receptors. Some noradrenergic nerve endings have also been shown to possess beta-adrenergic receptors, the stimulation of which increases the quantity of transmitter released by nerve impulses. Physiologically, these receptors could be activated by circulating epinephrine (E) and be involved in essential hypertension. A third type of catecholamine receptor found at the noradrenergic nerve ending is the inhibitory dopamine (DA) receptor, which might be of significance in the development of new antihypertensive agents. Application of these new concepts of noradrenergic neurotransmission and the subclassification of alpha-adrenoceptors to the treatment of hypertension is presented. Clonidine, for example, appears to be a potent alpha 2-adrenoceptor agonist; the central receptor involved in its antihypertensive action is pharmacologically an alpha 2-type but located postsynaptically. Clonidine also induces activation of peripheral presynaptic alpha 2-adrenoceptors, which might contribute to its cardiovascular action. The antihypertensive effects of alpha-methyldopa are related to the formation of alpha-methylnorepinephrine, a preferential alpha 2-adrenoceptor agonist, which can stimulate peripheral presynaptic alpha 2-adrenoceptors leading to a decrease of NE release and a reduction in sympathetic tone. Prazosin is a new antihypertensive agent the mechanism of action of which involves a selective blockade of postsynaptic alpha 1-adrenoceptors. This drug does not antagonize several effects of clonidine that are mediated via alpha 2-adrenoceptors. The mechanisms presently considered to account for the antihypertensive activity of beta-adrenoceptor blocking agents are numerous. It is proposed that blockade of peripheral presynaptic facilitatory beta-adrenoceptors could be of significance in the antihypertensive action of these drugs.
In-Utero Low-Dose Irradiation Leads to Persistent Alterations in the Mouse Heart Proteome (2016)

Prenatal exposure to stress such as increased level of reactive oxygen species or antiviral therapy are known factors leading to adult heart defects. The risks following a radiation exposure during fetal period are unknown, as are the mechanisms of any potential cardiac damage. The aim of this study was to gather evidence for possible damage by investigating long-term changes in the mouse heart proteome after prenatal exposure to low and moderate radiation doses. Pregnant C57Bl/6J mice received on embryonic day 11 (E11) a single total body dose of ionizing radiation that ranged from 0.02 Gy to 1.0 Gy. The offspring were sacrificed at the age of 6 months or 2 years. Quantitative proteomic analysis of heart tissue was performed using Isotope Coded Protein Label technology and tandem mass spectrometry. The proteomics data were analyzed by bioinformatics and key changes were validated by immunoblotting. Persistent changes were observed in the expression of proteins representing mitochondrial respiratory complexes, redox and heat shock response, and the cytoskeleton, even at the low dose of 0.1 Gy. The level of total and active form of the kinase MAP4K4 that is essential for the embryonic development of mouse heart was persistently decreased at the radiation dose of 1.0 Gy. This study provides the first insight into the molecular mechanisms of cardiac impairment induced by ionizing radiation exposure during the prenatal period.
Reproducing Material Appearance of Real Objects Using Mobile Augmented Reality (2018)

In this paper, we propose a system that can reproduce the material appearance of real objects using mobile augmented reality (AR). Our proposed system allows a user to manipulate a virtual object, whose model is generated from the shape and reflectance of a real object, using the user's own hand. The shape of the real object is reconstructed by integrating depth images of the object, which are captured using an RGB-D camera from different directions. The reflectance of the object is obtained by estimating the parameters of a reflectance model from the reconstructed shape and color images, assuming that a single light source is attached to the camera. We measured the shape and reflectance of some real objects and presented the material appearance of the objects using mobile AR. It was confirmed that users were able to obtain the perception of materials from changes in gloss and burnish of the objects by rotating the objects using their own hand.
ChemInform Abstract: BICYCLIC AMINOPHOSPHITES AS NITROGEN‐DONORS TOWARDS TUNGSTEN(VI) OXOALKOXIDES (1984)

Abstract Die Struktur des aufgezeichneten bicyclischen Aminophosphits, in dem das N‐Atom eine pyramidale Konfiguration besitzt, ermöglicht dem P‐benachbarten N‐Atom, als Donator zu fungieren.
The relation between blood lactate and ammonia in ischemic handgrip exercise (1985)

Subjects with myopathies associated with certain enzyme defects often show abnormal concentrations of lactate (LA) and ammonia (NH3) in blood after ischemic exercise. Myoadenylate deaminase (MAD) deficient patients produce only small amounts of NH3, whereas LA rises to normal levels. On the other hand, patients with certain enzyme deficiencies in the glyco(geno)lytic pathway show the opposite. However, the concentrations in blood are dependent on the exercise performed. Standardization of tests for screening purposes, therefore, is necessary. For ischemic contractions, experiments were performed to find the optimal combination for force and frequency, using the highest LA and NH3 concentrations in blood as criteria. Eleven healthy subjects performed ischemic isometric contractions with a handgrip dynamometer at frequencies of 30 and 50/min(-1) and force levels of 50%, 65%, and 80% of maximal voluntary contraction (MVC). A combination of 30/min(-1) and 80% MVC was found to give the best results.
Effect of Saturation on Rotational Flux Distribution in Hydro Generators (2016)

Uprating of hydro generators requires studies to determine the potential areas of failure like hotspots in the machine core. Rotational core losses cause localized heating of the core; therefore, understanding the distribution and behavior of rotational flux in the machine is the key. This paper studies the distribution of rotational flux in a hydro generator as the core material is saturated. The percentage of rotational flux in the stator increases as the material is saturated, especially for aspect ratios above 0.6. This affects the loss distribution and total losses in the machine. Core losses at no load and full load are also computed considering the change in flux distribution, and an increase of over 50% in the total stator core losses is calculated. Moreover, experimental core loss data of nonsinusoidal flux densities in various parts of the machine at no load and full load operation are also presented.
Scutellaria lateriflora "?appr. S. epilobifolia Ham." JBN (2015)

https://thekeep.eiu.edu/herbarium_specimens_byname/18696/thumbnail.jpg
STRATEGIES AND TECHNOLOGY FOR MANAGING HIGH-CARBON ASH (2002)

The overall objective of the present project is to identify and assess strategies and solutions for the management of industry problems related to carbon in ash. Specific research issues to be addressed include: (1) the effect of parent fuel selection on ash properties and adsorptivity, including a first ever examination of the air entrainment behavior of ashes from alternative (non-coal) fuels; (2) the effect of various low-NOx firing modes on ash properties and adsorptivity; and (3) the kinetics and mechanism of ash ozonation. This data will provide scientific and engineering support of the ongoing process development activities. During this fourth project period we completed the characterization of ozone-treated carbon surfaces and wrote a comprehensive report on the mechanism through which ozone suppresses the adsorption of concrete surfactants.
Strategies for the Synthesis of Poly(2‐Oxazoline)‐Based Hydrogels (2012)

Poly(2-oxazoline)-based networks currently receive great interest due to their versatile properties that can be tailor made by desktop-planned modifications. This feature summarizes strategies for the preparation of these networks, comprising the in situ cross-linking as well as polymer-analogous cross-linking routines such as (reversible) complex formation, physical processes, and covalent bond formation (involving reactions with olefinic species as well as with epoxides, isocyanates, aldehydes, acids, and their derivatives). Reflecting prominent application examples in the biomedic(in)al sector, poly(2-oxazoline)-co-polyester networks are described in a dedicated section.
Silicon on thin BOX: a new paradigm of the CMOSFET for low-power and high-performance application featuring wide-range back-bias control (2005)

We demonstrate a new MOSFET on ultra-thin BOX that allows wide-range back-bias control in low-power and high-performance applications. The back gate is effective not only to increase the drive current by about 20% in active mode but also in reduce the off-current by an order of magnitude in stand-by mode. We have also demonstrated tunable-threshold-voltage technology for devices with metal gates and ion implantation for V/sub th/ control. The target V/sub th/ for low-power applications was achieved by using ion implantation for V/sub th/ control. We propose a 6-transistor SRAM memory cell in which we obtain even more benefit from the new device structure by adding a feedback mechanism. A proposed 6-Tr SRAM memory cell is shown to dramatically improve SNM characteristics at the 65-nm technology nodes, and this effect will also apply at finer nodes.
A new approach for fast handovers in mobile multimedia networks (2005)

This paper focuses on the performance evaluation of a novel scheme that exploits the inter access point protocol (IAPP), standardized by IEEE, in order to expedite the RSVP path reestablishment that takes place after a handover from one WLAN access point (AP) to another. The prime characteristic of this scheme is that a WLAN AP serves as a resource reservation protocol (RSVP) proxy that starts RSVP signaling on behalf of the mobile node much earlier compared with the standard RSVP operation in a WLAN. Therefore, a considerable handover latency reduction can be achieved, which can be as high as 30% under heavy traffic conditions. To evaluate the performance and the benefits of the proposed scheme, we display and discuss a series of simulation results.
Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. VOLUME 283 (2008) PAGES 2724-2733 (2008)

On Page 2724, the grant number was incorrect. The grant information footnote should read as follows: This work was supported in part by Israel Science Foundation Grant 291/06, the Center for the Study of Emerging Diseases, and the fund for the promotion of research at the Technion (to B. Z. L.).
N-polar AlN thin layers grown on Si(111) by plasma-assisted MBE (2014)

The influence of RF power on the growth of N-polar AlN thin layers on Si(111) by plasma-assisted molecular beam epitaxy was systematically studied. The surface reconstruction of AlN was 1 × 1 for samples grown at RF power of 350–450 W, while samples grown at lower power of 150–300 W had 3 × 6 reconstruction. All samples demonstrate smooth surface with root mean square roughness less than 1 nm. The 45 nm thick AlN sample grown at RF power of 150 W has the best structural quality. The screw and edge dislocation densities estimated for this sample were 1.4 × 109 and 5.9 × 109 cm−2, respectively.
Sn122-:  Stannaspherene (2006)

Stannaspherene. The Sn122- cluster is discovered to be a highly stable and highly symmetric icosahedral cage bonded by four delocalized radial π bonds and nine delocalized on-sphere σ bonds from the 5p orbitals of the Sn atoms. It has a diameter of 6.1 Å, with a large empty interior volume, and can host most transition metal atoms inside, giving rise to a large class of endohedral chemical building blocks for cluster-assembled nanomaterials.
Computing Activity Coefficients of Binary Lennard-Jones Mixtures by Gibbs-Duhem Integration (2008)

We determine activity coefficients of both components of different binary Lennard-Jones mixtures obtained at T * = 2.0 and ρ * = 0.6 by using two different strategies: (i) direct evaluation of the excess chemical potentials of both components applying the potential distribution theorem, and (ii) using the Gibbs-Duhem integration based on the activity coefficients of the counter-component, which was calculated directly from the potential distribution theorem approach. Both methods lead numerically to similar results and therefore offer a route to determine activity coefficients of mixtures with large complex molecules by alternatively calculating chemical potentials of potentially simpler counter-constituents.
The distributed V kernel and its performance for diskless workstations (1983)

The distributed V kernel is a message-oriented kernel that provides uniform local and network interprocess communication. It is primarily being used in an environment of diskless workstations connected by a high-speed local network to a set of file servers. We describe a performance evaluation of the kernel, with particular emphasis on the cost of network file access. Our results show that over a local network: 1. Diskless workstations can access remote files with minimal performance penalty. 2. The V message facility can be used to access remote files at comparable cost to any well-tuned specialized file access protocol. We conclude that it is feasible to build a distributed system with all network communication using the V message facility even when most of the network nodes have no secondary storage.
Evaluation of upper extremity reachable workspace using Kinect camera (2013)

The findings indicate that the proposed Kinect-based 3D reachable workspace analysis provides sufficiently accurate and reliable results as compared to motion capture system. The proposed method could be promising for clinical evaluation of upper extremity in neurological or musculoskeletal conditions.
Preparation of a Series of Novel Bichalcones Linked with a 1,4-Dimethylenepiperazine Moiety and Examination of Their Cytotoxicity (2011)

The chalcone basic skeleton is a unique template which is associated with widespread biological activities. In the present study, a series of novel bichalcones linked with a 1,4-dimethylenepiperazine moiety was prepared through Mannich reaction and Clasien-Schmidt condensation. The synthetic analogs 2-16 were subjected into the cytotoxicity examinations using a panel of 25 human tumor cell lines. Among the tested compounds, 3 and 4 which possessed the 3-pyridyl and phenyl groups as the substructure, respectively, displayed significant cytotoxicity against all the tumor cell lines. The results suggested that these bichalcones were potential to be the anticancer lead drugs.
Space charge in proton linacs (1998)

Space charge effects on beam dynamics in linear accelerators are discussed. Practical linac beam dynamics calculation methods which include space charge effects are discussed. Also, the status of beam performance experiments including space charge studies are summarized.