gebhart/patrepeval huggingface dataset:
Lovastatin enhances the photocytotoxicity of UVA radiation towards cultured N.C.T.C. 2544 human keratinocytes: prevention by cholesterol supplementation and by a cathepsin inhibitor (1995)

The effect of the hydroxymethylglutaryl-CoA (HMG-CoA) inhibitor lovastatin on the UVA-induced photocytotoxicity has been investigated in cultured human N.C.T.C. 2544 keratinocytes. In the absence of irradiation, 5 x 10(-7) M lovastatin did not exhibit any significant cytotoxic effect towards this cell line. Although the drug cannot act as a photosensitizer, because it does not absorb in the UVA range, it markedly increased the UVA-induced cellular damage (about 70% reduction in cell viability at 5 x 10(-7) M). This effect was not accompanied by an increase in the lipid peroxidation product content of cells as compared with treatment with UVA alone. Medium supplementation with 0.01 mg/ml free cholesterol totally prevented the enhancement of UVA photocytotoxicity induced by lovastatin. A protective effect was also observed when cells were supplemented with an amount of low-density lipoprotein giving the same cholesterol concentration in the culture medium. Finally, E64 [L-trans-epoxysuccinyl-leucylamido-(4-guanidino)-butane], a lysosomal cathepsin inhibitor, also prevents the cell death induced by UVA in cells treated with lovastatin. These results suggest that HMG-CoA reductase inhibitors could increase the sensitivity of skin cells to UVA radiation, and that this phenomenon is related to lysosomal enzyme release.
Caractérisation de défauts plans en bordure de soudure par imagerie TFM sélective. (2017)

La detection et la caracterisation par ultrasons des defauts plans de type fissure depend fortement de l’expertise de l’operateur. Ce type de defaut est represente par un groupe d’echos produits a ces extremites, et la presence d’autres echos lies a la geometrie est une complication supplementaire. Le controle des soudures est representatif de ces difficultes, et les fissures sont tres sensibles pour la sante des assemblages. L’imagerie TFM appliquee au controle non destructif presente un nouvel interet car elle produit directement des images realistes, facilitant l’interpretation des resultats du controle et offrant de nouvelles perspectives de caracterisation des defauts.Cette methode est basee sur un calcul de temps de parcours entre les elements du capteur multielements et chaque point de l’image a former. Suivant que l’on considere des trajets directs entre le capteur et le defaut, des trajets indirects avec un ou plusieurs rebonds sur les parois de la piece, avec ou sans conversion de modes, il possible de considerer un grand nombre de modes de reconstruction pour une meme acquisition. Les images associees a ces modes peuvent etre porteuses d’informations differentes, parfois complementaires sur un meme defaut. La complementarite et la pertinence de chacune d’entre elles peut cependant varier en fonction de la configuration d’inspection et du type de defaut recherche. Il est donc important de selectionner les trajets pertinents au prealable. Une methode de prediction des modes de reconstruction pertinents a ete developpee et est mise en œuvre sur differents cas d’entailles en bordure de soudure. Les resultats issus de la simulation et de l’experience sont presentes pour a son appui.
Hardness of Submodular Cost Allocation: Lattice Matching and a Simplex Coloring Conjecture (2014)

We consider the Minimum Submodular Cost Allocation (MSCA) problem. In this problem, we are given k submodular cost functions f_1, ... , f_k: 2^V -> R_+ and the goal is to partition V into k sets A_1, ..., A_k so as to minimize the total cost sum_{i = 1}^k f_i(A_i). We show that MSCA is inapproximable within any multiplicative factor even in very restricted settings; prior to our work, only Set Cover hardness was known. In light of this negative result, we turn our attention to special cases of the problem. We consider the setting in which each function f_i satisfies f_i = g_i + h, where each g_i is monotone submodular and h is (possibly non-monotone) submodular. We give an O(k log |V|) approximation for this problem. We provide some evidence that a factor of k may be necessary, even in the special case of HyperLabel. In particular, we formulate a simplex-coloring conjecture that implies a Unique-Games-hardness of (k - 1 - epsilon) for k-uniform HyperLabel and label set [k]. We provide a proof of the simplex-coloring conjecture for k=3.
Lysyl Oxidase Propeptide Inhibits FGF-2-induced Signaling and Proliferation of Osteoblasts (2010)

Pro-lysyl oxidase is secreted as a 50-kDa proenzyme and is then cleaved to a 30-kDa mature enzyme (lysyl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxidase propeptide (LOX-PP)). The presence of LOX-PP in the cell layers of phenotypically normal osteoblast cultures led us to investigate the effects of LOX-PP on osteoblast differentiation. Data indicate that LOX-PP inhibits terminal mineralization in primary calvaria osteoblast cultures when added at early stages of differentiation, with no effects seen when present at later stages. LOX-PP was found to inhibit serum- and FGF-2-stimulated DNA synthesis and FGF-2-stimulated cell growth. Enzyme-linked immunosorbent assay and Western blot analyses show that LOX-PP inhibits FGF-2-induced ERK1/2 phosphorylation, signaling events that mediate the FGF-2-induced proliferative response. LOX-PP inhibits FGF-2-stimulated phosphorylation of FRS2alpha and FGF-2-stimulated DNA synthesis, even after inhibition of sulfation of heparan sulfate proteoglycans. These data point to a LOX-PP target at or near the level of fibroblast growth factor receptor binding or activation. Ligand binding assays on osteoblast cell layers with (125)I-FGF-2 demonstrate a concentration-dependent inhibition of FGF-2 binding to osteoblasts by LOX-PP. In vitro binding assays with recombinant fibroblast growth factor receptor protein revealed that LOX-PP inhibits FGF-2 binding in an uncompetitive manner. We propose a working model for the respective roles of LOX enzyme and LOX-PP in osteoblast phenotype development in which LOX-PP may act to inhibit the proliferative response possibly to allow cells to exit from the cell cycle and progress to the next stages of differentiation.
DISEASES OF THE RETINA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Vaccination with Leishmania Hemoglobin Receptor–Encoding DNA Protects Against Visceral Leishmaniasis (2013)

Leishmaniasis is a severe infectious disease. Drugs used for leishmaniasis are very toxic, and no vaccine is available. We found that the hemoglobin receptor (HbR) of Leishmania was conserved across various strains of Leishmania, and anti-HbR antibody could be detected in kala-azar patients' sera. Our results showed that immunization with HbR-DNA induces complete protection against virulent Leishmania donovani infection in both BALB/c mice and hamsters. Moreover, HbR-DNA immunization stimulated the production of protective cytokines like interferon-γ (IFN-γ), interleukin-12 (IL-12), and tumor necrosis factor-α (TNF-α) with concomitant down-regulation of disease-promoting cytokines like IL-10 and IL-4. HbR-DNA vaccination also induced a protective response by generating multifunctional CD4(+) and CD8(+) T cells. All HbR-DNA-vaccinated hamsters showed sterile protection and survived during an experimental period of 8 months. These findings demonstrate the potential of HbR as a vaccine candidate against visceral leishmaniasis.
Data from Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;FOLFOX, FOLFIRI, or FOLFOXIRI chemotherapy with bevacizumab is considered standard first-line treatment option for patients with metastatic colorectal cancer (mCRC). We developed and validated a molecular signature predictive of efficacy of oxaliplatin-based chemotherapy combined with bevacizumab in patients with mCRC.&lt;/p&gt;Experimental Design:&lt;p&gt;A machine-learning approach was applied and tested on clinical and next-generation sequencing data from a real-world evidence (RWE) dataset and samples from the prospective TRIBE2 study resulting in identification of a molecular signature, FOLFOX&lt;i&gt;ai&lt;/i&gt;. Algorithm training considered time-to-next treatment (TTNT). Validation studies used TTNT, progression-free survival, and overall survival (OS) as the primary endpoints.&lt;/p&gt;Results:&lt;p&gt;A 67-gene signature was cross-validated in a training cohort (&lt;i&gt;N&lt;/i&gt; = 105) which demonstrated the ability of FOLFOX&lt;i&gt;ai&lt;/i&gt; to distinguish FOLFOX-treated patients with mCRC with increased benefit from those with decreased benefit. The signature was predictive of TTNT and OS in an independent RWE dataset of 412 patients who had received FOLFOX/bevacizumab in first line and inversely predictive of survival in RWE data from 55 patients who had received first-line FOLFIRI. Blinded analysis of TRIBE2 samples confirmed that FOLFOX&lt;i&gt;ai&lt;/i&gt; was predictive of OS in both oxaliplatin-containing arms (FOLFOX HR, 0.629; &lt;i&gt;P&lt;/i&gt; = 0.04 and FOLFOXIRI HR, 0.483; &lt;i&gt;P&lt;/i&gt; = 0.02). FOLFOX&lt;i&gt;ai&lt;/i&gt; was also predictive of treatment benefit from oxaliplatin-containing regimens in advanced esophageal/gastro-esophageal junction cancers, as well as pancreatic ductal adenocarcinoma.&lt;/p&gt;Conclusions:&lt;p&gt;Application of FOLFOX&lt;i&gt;ai&lt;/i&gt; could lead to improvements of treatment outcomes for patients with mCRC and other cancers because patients predicted to have less benefit from oxaliplatin-containing regimens might benefit from alternative regimens.&lt;/p&gt;&lt;/div&gt;
FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells (2013)

Host immune peptides, including cathelicidins, have been reported to possess anticancer properties. We previously reported that LL-37, the only cathelicidin in humans, suppresses the development of colon cancer. In this study, the potential anticancer effect of FK-16, a fragment of LL-37 corresponding to residues 17 to 32, on cultured colon cancer cells was evaluated. FK-16 induced a unique pattern of cell death, marked by concurrent activation of caspase-independent apoptosis and autophagy. The former was mediated by the nuclear translocation of AIF and EndoG whereas the latter was characterized by enhanced expression of LC3-I/II, Atg5 and Atg7 and increased formation of LC3-positive autophagosomes. Knockdown of Atg5 or Atg7 attenuated the cytotoxicity of FK-16, indicating FK-16-induced autophagy was pro-death in nature. Mechanistically, FK-16 activated nuclear p53 to upregulate Bax and downregulate Bcl-2. Knockdown of p53, genetic ablation of Bax, or overexpression of Bcl-2 reversed FK-16-induced apoptosis and autophagy. Importantly, abolition of AIF/EndoG-dependent apoptosis enhanced FK-16-induced autophagy while abolition of autophagy augmented FK-16-induced AIF-/EndoG-dependent apoptosis. Collectively, FK-16 induces caspase-independent apoptosis and autophagy through the common p53-Bcl-2/Bax cascade in colon cancer cells. Our study also uncovered previously unknown reciprocal regulation between these two cell death pathways.
Status Epilepticus and Tiagabine Therapy: Review of Safety Data and Epidemiologic Comparisons (2001)

Over a 3-year period, SE will occur in 5-10% of patients with epilepsy not in remission. At highest risk are those who have had a prior episode of SE. Treatment with TGB in recommended doses does not increase the risk of SE in patients with partial seizures.
CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS (1937)

1. Azoprotein antigens containing glucuronic and galacturonic acids give rise in rabbits to specific antibodies. The immune sera show no serological crossing with antigens containing glucose or galactose. 2. The galacturonic acid antigen reacts in antipneumococcus horse serum Type I in high dilutions. 3. Azoprotein antigens containing galacturonic acid, benzene sulfonic and carboxylic acids precipitate in antipneumococcus horse sera of various types but not in normal horse serum. The mechanism underlying these cross reactions is discussed.
Correlation Between Euro NCAP Pedestrian Test Results and Injury Severity in Injury Crashes with Pedestrians and Bicyclists in Sweden (2014)

Pedestrians and bicyclists account for a significant share of deaths and serious injuries in the road transport system. The protection of pedestrians in car-to-pedestrian crashes has therefore been addressed by friendlier car fronts and since 1997, the European New Car Assessment Program (Euro NCAP) has assessed the level of protection for most car models available in Europe. In the current study, Euro NCAP pedestrian scoring was compared with real-life injury outcomes in car-to-pedestrian and car-tobicyclist crashes occurring in Sweden. Approximately 1200 injured pedestrians and 2000 injured bicyclists were included in the study. Groups of cars with low, medium and high pedestrian scores were compared with respect to pedestrian injury severity on the Maximum Abbreviated Injury Scale (MAIS)-level and risk of permanent medical impairment (RPMI). Significant injury reductions to both pedestrians and bicyclists were found between low and high performing cars. For pedestrians, the reduction of MAIS2+, MAIS3+, RPMI1+ and RPMI10+ ranged from 20-56% and was significant on all levels except for MAIS3+ injuries. Pedestrian head injuries had the highest reduction, 80-90% depending on level of medical impairment. For bicyclist, an injury reduction was only observed between medium and high performing cars. Significant injury reductions were found for all body regions. It was also found that cars fitted with autonomous emergency braking including pedestrian detection might have a 60-70% lower crash involvement than expected. Based on these results, it was recommended that pedestrian protection are implemented on a global scale to provide protection for vulnerable road users worldwide.
Polymorphism of Ga2O3 and the System Ga2O3—H2O (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymorphism of Ga2O3 and the System Ga2O3—H2ORustum Roy, V. G. Hill, and E. F. OsbornCite this: J. Am. Chem. Soc. 1952, 74, 3, 719–722Publication Date (Print):February 1, 1952Publication History Published online1 May 2002Published inissue 1 February 1952https://pubs.acs.org/doi/10.1021/ja01123a039https://doi.org/10.1021/ja01123a039research-articleACS PublicationsRequest reuse permissionsArticle Views5545Altmetric-Citations843LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A GUI Crawling-Based Technique for Android Mobile Application Testing (2011)

As mobile applications become more complex, specific development tools and frameworks as well as cost effective testing techniques and tools will be essential to assure the development of secure, high-quality mobile applications. This paper addresses the problem of automatic testing of mobile applications developed for the Google Android platform, and presents a technique for rapid crash testing and regression testing of Android applications. The technique is based on a crawler that automatically builds a model of the application GUI and obtains test cases that can be automatically executed. The technique is supported by a tool for both crawling the application and generating the test cases. In the paper we present an example of using the technique and the tool for testing a real small size Android application that preliminary shows the effectiveness and usability of the proposed testing approach.
An ultra-low phase noise 3.37 –3.58 GHz MEMS varactor based VCO with continuous frequency tuning (2016)

This paper presents a VCO that utilizes the analog capacitive tuning properties of a MEMS varactor for continuous frequency tuning. The MEMS based VCO achieves a tuning range from 3.37 to 3.58 GHz and a superior phase noise performance of -134.5 dBc/Hz at a 500 kHz offset from the carrier. This work shows the potential of MEMS varactors as attractive alternative to standard varactor solutions for frequency tuning of high performance VCOs.
Identification and mapping of the novel apple scab resistance gene Vd3 (2009)

Apple scab, caused by the fungal pathogen Venturia inaequalis, is one of the most devastating diseases for the apple growing in temperate zones with humid springs and summers. Breeding programs around the world have been able to identify several sources of resistance, the Vf from Malus floribunda 821 being the most frequently used. The appearance of two new races of V. inaequalis (races 6 and 7) in several European countries that are able to overcome the resistance of the Vf gene put in evidence the necessity of the combination of different resistance genes in the same genotype (pyramiding). Here, we report the identification and mapping of a new apple scab resistance gene (Vd3) from the resistant selection “1980-015-25” of the apple breeding program at Plant Research International, The Netherlands. This selection contains also the Vf gene and the novel V25 gene for apple scab resistance. We mapped Vd3 on linkage group 1, 1 cM to the south of Vf in repulsion phase to it. Based on pedigree analysis and resistance tests, it could be deduced that 1980-015-25 had inherited Vd3 from the founder “D3.” This gene provides resistance to the highly virulent EU-NL-24 strain of race 7 of V. inaequalis capable of overcoming the resistance from Vf and Vg.
Latency-Memory Optimized Splitting of Convolution Neural Networks for Resource Constrained Edge Devices (2022)

With the increasing reliance of users on smart devices, bringing essential computation at the edge has become a crucial requirement for any type of business. Many such computations utilize Convolution Neural Networks (CNNs) to perform AI tasks, having high resource and computation requirements, that are infeasible for edge devices. Splitting the CNN architecture to perform part of the computation on edge and remaining on the cloud is an area of research that has seen increasing interest in the field. In this paper, we assert that running CNNs between an edge device and the cloud is synonymous with solving a resource-constrained optimization problem that minimizes the latency and maximizes resource utilization at the edge. We formulate a multi-objective optimization problem and propose the LMOS algorithm to achieve a Pareto efficient solution. Experiments done on real-world edge devices show that LMOS ensures feasible execution of different CNN models at the edge and also improves upon existing state-of-the-art approaches.
Meat quality and protein quality (1976)

Abstract Samples of meat of good and poor eating quality were assayed biologically for protein quality and analysed for connective tissue content. the low quality meat had NPU 69 and 23.6% connective tissue; the high quality meat had NPU 82 and 2.5% collagen.
How far are vowel formants from computed vocal tract resonances? (2012)

We compare numerically computed resonances of the human vocal tract with formants that have been extracted from speech during vowel pronunciation. The geometry of the vocal tract has been obtained by MRI from a male subject, and the corresponding speech has been recorded simultaneously. The resonances are computed by solving the Helmholtz partial differential equation with the Finite Element Method (FEM). Despite a rudimentary exterior space acoustics model, i.e., the Dirichlet boundary condition at the mouth opening, the computed resonance structure differs from the measured formant structure by $\approx$ 0.7 semitones for [i] and [u] having small mouth opening area, and by $\approx$ 3 semitones for vowels [a] and [ae] that have a larger mouth opening. The contribution of the possibly open velar port has not been taken into considaration at all which adds the discrepancy for [a] in the present data set. We conclude that by improving the exterior space model and properly treating the velar port opening, it is possible to computationally attain four lowest vowel formants with an error less than a semitone. The corresponding wave equation model on MRI-produced vocal tract geometries is expected to have a comparable accuracy.