gebhart/patrepeval huggingface dataset:
Computations of Turbulent Flow and Heat Transfer Through a Three-Dimensional Nonaxisymmetric Blade Passage (2008)

The design of a three-dimensional nonaxisymmetric end wall is carried out using three-dimensional numerical simulations. The computations have been conducted both for the flat and contoured end walls. The performance of the end wall is evaluated by comparing the heat transfer and total pressure loss reduction. The contouring is done in such a way to have convex curvature in the pressure side and concave surface in the suction side. The convex surface increases the velocity by reducing the local static pressure, while the concave surface decreases the velocity by increasing the local pressure. The profiling of the end wall is done by combining two curves, one that varies in the streamwise direction, while the other varies in the pitchwise direction. Several contoured end walls are created by varying the streamwise variation while keeping the pitchwise curve constant. The flow near the contoured end wall is seen to be significantly different from that near the flat end wall. The contoured end wall is found to reduce the secondary flow by decreasing radial pressure gradient. The total pressure loss is also lower and the average heat transfer reduces by about 8% compared to the flat end wall. Local reductions in heat transfer are significant (factor of 3). This study demonstrates the potential of three-dimensional end-wall contouring for reducing the thermal loading on the end wall.
Systematic review and meta‐analysis identify significant relationships between clinical anxiety and lower urinary tract symptoms (2021)

The results demonstrate a significant association between clinically significant anxiety and LUTS in both females and males. There were limited studies on younger individuals and on individuals ascertained for clinically significant anxiety, which should motivate further study in these areas. Understanding the co-occurrence of these conditions will lead to better prevention and interventions to ameliorate the progression of the symptoms and improve the quality of life. A thorough assessment of anxiety may provide more optimal care for LUTS patients.
Hierarchical Self-Assembly of Nano-Fibrils in Mineralized Collagen (2003)

A designed hierarchical structure was made by self-assembly of nano-fibrils of mineralized collagen resembling extracellular matrix. The collagen fibrils were formed by self-assembly of collagen triple helices. Hydroxyapatite (HA) crystals grew on the surface of these fibrils in such a way that their c-axes were oriented along the longitudinal axes of the fibrils. The mineralized collagen fibrils aligned parallel to each other to form mineralized collagen fibers. For the first time, the new hierarchical self-assembly structure of collagen−hydroxyapatite composite was verified by conventional and high-resolution transmission electron microscopy.
Enhanced Interfacial Toughness of Thermoplastic–Epoxy Interfaces Using ALD Surface Treatments (2019)

Interfacial fracture and delamination of polymer interfaces can play a critical role in a wide range of applications, including fiber-reinforced composites, flexible electronics, and encapsulation layers for photovoltaics. However, owing to the low surface energy of many thermoplastics, adhesion to dissimilar material surfaces remains a critical challenge. In this work, we demonstrate that surface treatments using atomic layer deposition (ALD) on poly(methyl methacrylate) (PMMA) and fluorinated ethylene propylene (FEP) lead to significant increases in surface energy, without affecting the bulk mechanical response of the thermoplastic. After ALD film growth, the interfacial toughness of the PMMA-epoxy and FEP-epoxy interfaces increased by factors of up to 7 and 60, respectively. These results demonstrate the ability of ALD to engineer the adhesive properties of chemically inert surfaces. However, in the present case, the interfacial toughness was observed to decrease significantly with an increase in humidity. This was attributed to the phenomenon of stress-corrosion cracking associated with the reaction between Al<sub>2</sub>O<sub>3</sub> and water and might have a significant implication for the design of these tailored interfaces.
Biochemical and Clinical Manifestations of Dopamine-Producing Paragangliomas: Utility of Plasma Methoxytyramine (2005)

Measurements of plasma-free normetanephrine and metanephrine provide a sensitive test for diagnosis of pheochromocytoma but may fail to detect tumors that produce predominantly dopamine. Such tumors are extremely rare, usually found as extraadrenal paragangliomas. This report describes measurements of plasma concentrations of free methoxytyramine, the O-methylated metabolite of dopamine, in 120 patients with catecholamine-producing tumors, including nine with extraadrenal paragangliomas secreting predominantly dopamine. In seven of these nine patients, tumors were found incidentally or secondary to the space-occupying complications of the lesions. Plasma concentrations of free methoxytyramine and dopamine were increased in all nine patients, including two with normal plasma and urinary normetanephrine and metanephrine and normal urinary outputs of dopamine. Relative increases above normal for plasma methoxytyramine (104-fold) and dopamine (56-fold) were much greater (P < 0.001) than those for urinary dopamine (3-fold). Insensitivity of the latter for identification of dopamine-secreting tumors was due to dependence of the urinary amine on renal extraction and decarboxylation of circulating 3,4-dihydroxyphenylalanine. Measurements of plasma-free methoxytyramine, in addition to normetanephrine and metanephrine, are unlikely to improve diagnosis of pheochromocytomas in hypertensive patients with symptoms of catecholamine excess but may be useful in selected patients for identification of tumors that produce predominantly dopamine.
Design a pocket multi-bit multiplier in FPGA (2002)

The multi-bit multiplier is an arithmetic unit which is often used in digital electronic systems and digital signal processors. There are two kinds of algorithm for performing multi-bit multiplication. According to the algorithm given in the paper, two kinds of simple multi-bit multiplier are introduced. Dealing with the structure of the combinational multiplier and sequential multiplier, the paper presents a discussion on the delay and resource utilization ration of an FPGA. The sequential multiplier has a more compact structure than the combinational multiplier. In the sequential multiplier, the carry circuit structure of the adder unit has an important influence on delay and resource utilization of the LCA. The connection mode of the adder unit given in the paper is acceptable and reasonable. The FPGA is an ideal device to implement a sequential multiplier. But if we want to design a more compact sequential multiplier in FPGA, then there are still many problems to overcome.
Electroceramics from Source Materials via Molecular Intermediates: BaTiO 3 from TiO 2 via (Ti(catecholate) 3 ) 2‐ (1990)

Rutile or anatase may be depolymerized and complexed by sequential treatment with (i) H 2 SO 4 /(NH 4 ) 2 SO 4 , (ii) H 2 O, and (iii) catechol/NH 4 OH to produce the intermediate (NH 4 ) 2 (Ti(catecholate) 3 ) · 2H 2 O. Treatment with Ba(OH) 2 · 8H 2 O leads to an acid‐base reaction generating Ba(Ti(catecholate) 3 ) · 3H 2 O, in which the Ba:Ti ratio is held at 1:1 at the molecular level. Calcination produces BaTiO 3 powder.
Nutritional and Functional Properties of Some Promising Legumes Protein Isolates (2010)

Proteins are essential component of diet performing multifarious role in human body. Present project was an attempt to extract and characterize legumes protein isolates for their functional properties. Four different legumes i.e. cowpea, pigeon pea, peas and mungbean were evaluated for protein content, functional properties and their ability to improve nutritional quality of foods. Cowpea exhibited maximum protein content 27.88±1.95% followed by mungbean, peas and pigeon pea. As for as functional properties are concerned, cowpea protein isolates showed highest bulk density 0.71±0.05 g/cm however, maximum 3 protein solubility 82±4.97 was observed in pea protein isolates. Maximum water and oil absorption capacity 163±10.05, 168±11.72% was observed in mungbean and pigeon pea protein isolates, respectively. Likewise different legumes protein isolates showed significant results for emulsifying, foaming and gelling properties.
GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions (2019)

Drug resistance diagnostics that rely on the detection of resistance-related mutations could expedite patient care and TB eradication. We perform minimum inhibitory concentration testing for 12 anti-TB drugs together with Illumina whole-genome sequencing on 1452 clinical Mycobacterium tuberculosis (MTB) isolates. We evaluate genome-wide associations between mutations in MTB genes or non-coding regions and resistance, followed by validation in an independent data set of 792 patient isolates. We confirm associations at 13 non-canonical loci, with two involving non-coding regions. Promoter mutations are measured to have smaller average effects on resistance than gene body mutations. We estimate the heritability of the resistance phenotype to 11 anti-TB drugs and identify a lower than expected contribution from known resistance genes. This study highlights the complexity of the genomic mechanisms associated with the MTB resistance phenotype, including the relatively large number of potentially causal loci, and emphasizes the contribution of the non-coding portion of the genome.
Performance of a Cryogen-Free 30 T-Class Hybrid Magnet (2006)

The world's first cryogen-free hybrid magnet, which was developed at the High Field Laboratory for Superconducting Materials in order to realize an easy-operational magnet system with no use of liquid helium and nitrogen, has achieved 22.7 T in a 52 mm room temperature bore. After this success, we started to construct a new cryogen-free 30 T-class hybrid magnet, consisting of an outer wide-bore cryogen-free 11 T superconducting magnet and an inner water-cooled 19 T resistive magnet. Up to now, the NbTi outer section coil and the Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn inner one of a wide-bore cryogen-free superconducting magnet has generated individual central fields of 5.3 T at 350 A and 5.8 T at 303 A, respectively in a 360 mm room temperature bore. The wide-bore cryogen-free superconducting magnet was energized up to 9.5 T as a total background field. In hybrid magnet mode the system was operated up to an 8.5 T background field form the cryogen-free superconducting magnet, because a cooling problem was encountered with the innermost coil bobbin during ramping the Bitter magnet. As a result, the cryogen-free hybrid magnet generated 27.5 T in a 32 mm room temperature bore
TUMOR ANGIOGENESIS AND OUTCOME IN OSTEOSARCOMA (2004)

Intratumoral angiogenesis quantified by microvessel density (MVD) has been shown to be a strong prognostic indicator in a number of malignant tumors. Its association with prognosis in bone sarcomas has been subject to less extensive research. The aim of this study was to investigate prognostic significance of angiogenesis in osteosarcoma. Thirty-nine patients with osteosarcoma were included in a retrospective immunohistochemical study. Sections from diagnostic biopsies were immunostained using anti-von Willebrand factor antibody and microvessels were counted at 400 x magnification on 3 microscopic fields per patient. MVD was correlated with overall and disease-free survival by Kaplan-Meier and log-rank analysis. Correlation between clinicopathological variables and the degree of angiogenesis was tested using a chi 2 test. Significant statistical difference was found regarding overall survival and disease-free survival between patients with high (> 32.3 vessels/field) and low (< or = 32.3 vessels/field) microvessel counts (log-rank test p = .0196 and p = .0147, respectively). The rate of metastasis was significantly higher in patients with high microvessel counts (p = .042). These findings strongly suggest that angiogenesis quantified by microvessel density is predictive of metastasis and poor prognosis in osteosarcoma.
Maturity-Onset Diabetes of the Young (MODY): Genetic and Clinical Characteristics (2002)

Maturity-onset diabetes of the young (MODY) is a genetically and clinically heterogeneous subtype of familial diabetes mellitus characterized by early onset, autosomal dominant inheritance and primary defects of insulin secretion. Mutations in six genes cause most of the MODY cases. These genes encode the enzyme glucokinase and the transcription factors hepatocyte nuclear factor 4alpha, hepatocyte nuclear factor 1alpha, insulin promoter factor-1, hepatocyte nuclear factor 1beta and neuroD1. Additional MODY genes remain to be identified. The study of families with MODY has shown that the different MODY subtypes present different metabolic and clinical profiles.
An integrated 3D sound intensity sensor using four-wire particle velocity sensors: II. Modelling (2009)

The sensitivity of a micromachined acoustic sensor consisting of four hot-wire particle velocity sensors is analysed theoretically and experimentally. The device and its fabrication have been presented in part 1 of this paper (Yntema et al 2010 J. Micromech. Microeng. 20 015042). A relatively straightforward analytical model is presented that describes both the air flow around the probe and the temperature profile around the heated wires. The presence of the chip surface near the heated wires influences the fluid flow around the wires, while it also affects the temperature distribution in the probe by altering the direction of heat transport. Both effects result into a modified angular dependence of the sensor sensitivity with respect to the normal 'figure-of-eight' figure of the response. By means of finite elements software, the thermal and the acoustic flow behaviour of the sensor are also investigated numerically, both effects together and each apart, and the results are compared to the analytical model. Comparison with the experimental data is presented, showing that the model is appropriate to describe the angular dependence and the magnitude of the sensor response. It is concluded that the perturbed air flow due to the chip surface is the dominant reason for the observed angular sensitivity.
IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line. (2009)

We previously reported that matrix metalloproteinase (MMP)-10 mRNA levels were significantly lower in tumor tissues than in adjacent normal tissues in human non-small cell lung cancer (NSCLC), whereas protein levels of MMP-10 were higher in the tumor tissues than the adjacent tissues. The mechanism of this divergence is still unknown. In the present study the role of Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) on interleukin (IL)-6 mediated regulation of MMP-10 expression was investigated in a human lung adenocarcinoma cell line (A549 cells) and the molecular regulatory mechanism of MMP-10 expression was explored. A549 cells were stimulated by different concentrations of IL-6 with or without AG490, a specific JAK2 inhibitor. It was demonstrated that IL-6 moderately reduced the MMP-10 mRNA levels, whereas it significantly enhanced the MMP-10 protein mass in the A549 cells. This phenomenon mimicked the divergence of mRNA level and protein mass of MMP-10 in human NSCLC. Moreover, the present study indicated that IL-6 regulation of MMP-10 expression was via the JAK2/STAT3 pathway. STAT3 mRNA levels were significantly increased when the cells were treated with IL-6, whereas when AG490 (50 muM) was added to the cell cultures, IL-6-induced increase of STAT3 mRNA levels was abolished. Meanwhile, AG490 blocked the IL-6-induced inhibition of MMP-10 mRNA as well as blocking the IL-6-induced increase of MMP-10 protein mass in the A549 cells. Neither IL-6 nor AG490 influenced JAK2 mRNA levels in the A549 cell cultures. It is concluded that the JAK2/STAT3 pathway is involved in the IL-6-mediated regulation of MMP-10, and IL-6 can moderately reduce MMP-10 mRNA levels and strongly increase MMP-10 protein mass in human lung adenocarcinoma A549 cells. Contrasting effects of IL-6 on MMP-10 mRNA level and protein concentration in A549 cells may partially explain the divergence of MMP-10 mRNA level and protein mass in human NSCLC.
smAvo and smaTo: A fruity odyssey of smart sensor platforms in Southern Africa (2020)

Avocado and tomato production are key agricultural sectors for many economies including South Africa. The quality of avocadoes and tomatoes that reach consumers is directly dependent on the handling at the postharvest stage. The fruit undergoes an extensive journey, and subsequently stress, comprised of several steps, including harvesting, application of postharvest treatments, packaging and transportation by road and sea to reach the export markets. To date, the quantification of these external stresses on a discrete fruit has not been measured in detail, primarily due to a lack of compatible instrumentation. This paper demonstrates a low cost, stand-alone, open source data acquisition system, termed smAvo and smaTo, that can be introduced effortlessly to monitor agricultural processing facilities and transportation networks. The miniaturised Arduino sensor platform is enclosed within a waterproof enclosure and surrounded by a 3D printed shell manufactured from morphologically compatible materials. The software is customisable to the needs of the research project or individual transportation phases under study, providing both extensive environmental data and high-frequency tri-axis acceleration measurements that are crucial to understanding the dynamic processes that directly affect the final quality of the fruit. Four successful field trials demonstrate the fidelity of both the smAvo and smaTo platforms.
Atlantic salmon mortality at sea: Developing an evidence-based "Likely Suspects" Framework (2018)

Based on a workshop organised by the Atlantic Salmon Trust, held in Edinburgh Tuesday, 6th November – Thursday, 8th November 2017.
Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents (2018)

All compounds showed cytotoxic activity against hepatocellular (Huh7) and breast (MCF-7) cancer cell lines. Dihalo substituted benzylpiperazine derivatives (2a, 2e) had the highest cytotoxic activities in all the tested cell lines. In addition, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities of synthesized compounds were investigated by in vitro Ellman's method. Compound 2j led to moderate and selective inhibition against AChE. Docking study was utilized to understand the binding mode of compound 2j in comparision with donepezil on AChE. The other tested compounds showed weak or no inhibition against AChE as promising anticancer agents.
Interactions in the network of Usher syndrome type 1 proteins (2004)

Defects in myosin VIIa, harmonin (a PDZ domain protein), cadherin 23, protocadherin 15 and sans (a putative scaffolding protein), underlie five forms of Usher syndrome type I (USH1). Mouse mutants for all these proteins exhibit disorganization of their hair bundle, which is the mechanotransduction receptive structure of the inner ear sensory cells, the cochlear and vestibular hair cells. We have previously demonstrated that harmonin interacts with cadherin 23 and myosin VIIa. Here we address the extent of interactions between the five known USH1 proteins. We establish the previously suggested sans-harmonin interaction and find that sans also binds to myosin VIIa. We show that sans can form homomeric structures and that harmonin b can interact with all harmonin isoforms. We reveal that harmonin also binds to protocadherin 15. Molecular characterization of these interactions indicates that through its binding to four of the five USH1 proteins, the first PDZ domain (PDZ1) of harmonin plays a central role in this network. We localize sans in the apical region of cochlear and vestibular hair cell bodies underneath the cuticular plate. In contrast to the other four known USH1 proteins, no sans labeling was detected within the stereocilia. We propose that via its binding to myosin VIIa and/or harmonin, sans controls the hair bundle cohesion and proper development by regulating the traffic of USH1 proteins en route to the stereocilia.
High performance CUDA-based implementation for the 2D version of the Maximum Subarray Problem (MSP) (2012)

The Maximum Subarray Problem (MSP) finds a segment of an array that has the maximum summation over all the other possible combinations. Different applications for this problem exist in various fields like genomic sequence analysis, data mining and computer vision. Several optimum linear-time solutions exist for the 1D version, however, the known upper bounds for the 2D version are cubic or near-cubic time; which makes it a problem of high complexity. In this work, a stage by stage high performance Graphics Processing Unit (GPU)-based implementation for solving the 2D version of the problem in a linear time relying on the Compute Unified Device Architecture (CUDA) technology is presented. It achieves more than 7X of speedup in performance compared to a single-threaded sequential implementation on the Central Processing Unit (CPU) for an array of size 512 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
CNN-based AMC for Internet of Underwater Things (2021)

Automatic modulation classification (AMC) is a technique to identify the modulation of signals. Traditionally, this has been done through feature extraction; however, recently machine learning has been used. Convolutional neural networks (CNNs) are a type of deep learning that have the ability to learn feature extraction. They are excellent for classification, and analyzing large amounts of data. In this research, CNNs were used to automatically classify the modulation type of underwater acoustic signals. The architecture of the CNN was iteratively improved, until a final accuracy of approximately 93% was achieved. The training and testing was done using a dataset collected by Applied Research Laboratories at the University of Texas Austin.
Elevated nuclear TDP-43 induces constitutive exon skipping (2023)

Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 overexpression has been used to generate <i>in vitro</i> and <i>in vivo</i> model systems. Our study shows that excessive levels of nuclear TDP-43 protein lead to constitutive exon skipping that is largely species-specific. Furthermore, while aberrant exon skipping is detected in some human brains, it is not correlated with disease, unlike the incorporation of cryptic exons that occurs after loss of TDP-43. Our findings emphasize the need for caution in interpreting TDP-43 overexpression data, and stress the importance of controlling for exon skipping when generating models of TDP-43 proteinopathy. Understanding the subtle aspects of TDP-43 toxicity within different subcellular locations is essential for the development of therapies targeting neurodegenerative disease.