gebhart/patrepeval huggingface dataset:
Comparisons of Juvenile Hormone Hemolymph and Octopamine Brain Titers in Honey Bees (Hymenoptera: Apidae) Selected for High and Low Pollen Hoarding (2004)

We measured circulating levels of juvenile hormone III (JH) and brain region levels of dopamine, serotonin, and octopamine in honey bees, Apis mellifera L., from artificially selected high and low pollen-hoarding strains that show differences in their rate of behavioral development. One-day-old bees from the high pollen-hoarding strain had significantly higher JH titers than 1-d-old bees from a low pollen-hoarding strain. Conversely, there were no differences in JH levels in 12-d-old preforager bees from the high and low strains. Brain region levels of all three amines increased with age, but there were no differences between high and low pollen-hoarding bees in any of the three amines in any region of the brain. These results are consistent with the hypothesis that endocrine events occurring early in adulthood influence honey bee behavioral development.
Fabrication and optical properties of Pr3+-doped Ba (Sn, Zr, Mg, Ta) O3transparent ceramic phosphor (2018)

To the best of our knowledge, we have successfully fabricated a novel transparent ceramic phosphor of Pr<sup>3+</sup>-doped Ba (Sn, Zr, Mg, Ta) O<sub>3</sub> (Pr<sup>3+</sup>:BMT) via a high-temperature solid-state reaction method. The in-line transmittance of 59% at 650 nm was measured. The Pr<sup>3+</sup>:BMT ceramic phosphor can emit 650 nm red light excited by 447 nm blue light. The ceramic phosphor can still work at 383 K. The activation energy was calculated to be 0.17 eV. The efficiency of the ceramic phosphor is twice that of its powder phosphor. The Pr<sup>3+</sup>:BMT ceramic phosphor showed good thermal stability and enhanced the chromaticity of its white LEDs, which make it a promising red phosphor for lighting.
FAILURES AND COMPLICATIONS AFTER ARTHROSCOPIC ANTERIOR SHOULDER STABILIZATION (2008)

Purpose of the study: Analyze failures (recurrent anterior instability) and other complications (pain, stiffness) compromising the overall outcome after arthroscopic anterior shoulder stabilization. Material and methods: We studied failures and complications in a consecutive inaugural series of 43 patients undergoing an arthroscopic Bankart procedure for chronic anterior shoulder instability. The procedure was performed with knitted resorbable threads on metallic anchors. Outcome was reviewed at mean 26 months (range 6–63 months). There were 19 recurrent dislocations, 12 recurrent subluxations, 4 cases of recurrent subluxation and dislocation and 6 cases of painful unstable shoulder. Mean patient age was 35.6 years (range 19–59 years). Thirty-two patients practiced sports, including 21 who practiced high-risk sports. Results: One patient, a competition basketball player, presented recurrent traumatic dislocation due to a violent shock after premature resumption of sports activities five months after surgery. There were no recurrent dislocations among the subluxation cases. Pain persisted in three of the six painful unstable shoulders. Sixteen patients presented persistent apprehension but none complained of instability. Nine patients had a positive relocation test. Limited external rotation of less than 30% as observed in five patients and of 30–50% in two. Residual pain was observed in 14 patients (33%) (when carrying a heavy load with the arm hanging along the body, with fatigue, and for forced movements without warm-up in the morning). For four patients, pain occurred in the armed position. Seventeen patients (43%) interrupted their sports activity. The Duplay score showed 13 (30%) fair and poor objective overall results. Subjectively, only seven patients (15%) were only partially satisfied or dissatisfied. Discussion: Analysis of failures and complications disclosed a discordance between the low rate of failure using the classical definition (recurrent dislocation or subluxation) and the high rate of fair or poor overall outcomes. Residual pain and non-resumption of sports activities appeared to be the major problems. These two factors were analyzed in detail to compare this series with data in the literature. It was found that non-resumption of sports activities is not always related to shoulder instability or apprehension and that pain is often related to associated injury (SLAP, cuff). Conversely, pain associated with a positive relocation test should be considered as a true recurrence, especially in a subject who was unable to resume sports activities.
Images of First-time Visitors to Queen Charlotte Islands and Gwaii Haanas National Park Reserve (2002)

Gwaii Haanas National Park Reserve and Haida Heritage Site are located in British Columbia on the Queen Charlotte Islands archipelago, also known as Haida Gwaii. The Archipelago Management Board, which manages Gwaii Haanas National Park Reserve/Haida Heritage Site commissioned a comprehensive strategic tourism marketing effort to help ensure that tourism optimally contributes to the local heritage and the local quality of life. The study described in this paper was part of a larger research project developed to provide input to the tourism effort. The 1998 Queen Charlotte Islands/Haida Gwaii Visitor Survey and focus groups were developed in concert to obtain information useful to park management in understanding the region’s tourism system, and to forecast the outcomes of various scenarios for future management. Integral to a sound plan is a clear understanding of visitors’ images of the Queen Charlotte Islands/Haida Gwaii. Thus, this paper draws on the larger study to explore expectations and impressions of first-time visitors to Gwaii Haanas/Queen Charlotte Islands, a culturally and ecologically distinctive place. The goal of this paper is to enhance understanding of destination image shifts and the roles of visitation and information on place image. Results from 594 questionnaires and four focus groups shed light on the expected image and the resulting impressions held by first-time visitors to the Queen Charlotte Islands. Expectations were primarily related to attributes/features of the place (e.g., wildlife, Haida culture), while impressions were more evaluative of visitors’ experiences at the destination (e.g., excellent, peaceful, etc.). Composition of individuals’ images shifted from the destination environment (nature and culture) to their feelings about that environment (friendly, excellent, relaxing). This was evident in both survey and focus group results. The shift demonstrates a change from cognitive to affective image domains, providing further insight into components of image that are representative of first-time visitors. Information sources that played a role in creating visitors’ images generally were not under direct control of the destination; for example, coffee table books and newspaper articles. Theoretical contributions of these findings are discussed and practical implications for destination image and strategic tourism efforts on Queen Charlotte Islands are offered.
Research on adverse drug events. I. Muscarinic M3 receptor bindingaffinity could predict the risk of antipsychotics to induce type 2diabetes (2005)

Antipsychotics are associated with a wide range of adverse effects, several of which may represent a serious health risk to patients. There is an increased concern about metabolic disturbances associated with antipsychotics, including weight gain, dyslipidemia, hyperglycemia, and type 2 diabetes. However, little is known about the mechanisms underlying antipsychotic-induced metabolic disturbances and, in particular, those related to the induction of abnormal glucose metabolism and diabetes. The present article aimed to identify those receptor(s) that are most likely to be involved with or mediate antipsychotics-induced diabetes. Two independent measures taken from literature to indicate the risk of type 2 diabetes associated with 25 typical and atypical antipsychotic drugs were considered, along with their binding affinities to 21 specific receptors (obtained from the resources of Prous Science Integrity). A range of both exploratory and predictive statistical analyses were applied, including principal component factorial analysis, multivariable linear regression analysis, and discriminant analysis. Binding affinities (pKi) to human neurotransmitter receptors and monoaminergic transporters were used as independent variables (predictors). Measures to determine the risk to induce new-onset type 2 diabetes associated with each antipsychotic, logistic regression odds-ratio (dOR) and a discrete scale-based risk (three levels: 'low,' 'moderate,' 'high'), were used as the dependent variables (criteria). Similarly, parallel analyses were also conducted for other measures (average effective therapeutic dose) or adverse effects (weight gain, extrapyramidal side effects, hyperprolactinemia, anticholinergic, hypotension, and sedation) associated with antipsychotics, where underlying mechanisms have been previously established and, therefore, serve as positive-control references. Affinity for the cholinergic muscarinic M3 receptor subtype was presented as the best predictor for the propensity of antipsychotics to induce type 2 diabetes. This was independently revealed by means of multiple linear regression analysis, using the dOR as criterion (R=0.90, p<0.0001), and discriminant analysis, using the scale-based risk of type 2 diabetes (3 levels) as criterion (Wilks' lambda=0.33, chi2=14.11, p<0.001). To our knowledge, this study provides the first direct evidence to indicate that antipsychotic agents with high binding affinity to the muscarinic M3 receptor are associated with an elevated risk for type 2 diabetes. Rationale of the M3 receptor involvement in this adverse effect is discussed further in relation to M3 receptor mediation of glucose-dependent parasympathetic acetylcholine regulation of insulin secretion by pancreatic beta-cells. This study is the first in a series of investigations that aim to further our understanding of mechanisms underlying adverse drug effects.
DNA Replication Licensing Factors and Aurora Kinases are Linked to Aneuploidy and Clinical Outcome in Epithelial Ovarian Carcinoma (2007)

Our data show that Ki67, Mcm2, geminin and Aurora A and B can be used as an adjunct to conventional prognostic indicators and as an aid to develop a tumor progression model for EOC. Dysregulation of Aurora A seems to be an early event in EOC with a key role in tumor progression. In view of present drug development programs for specific Aurora kinase inhibitors, our findings have important implications for the use of Aurora A as a biomarker and as a potential therapeutic target.
Rotational selectivity in cyclobutene ring openings. Model studies directed toward a synthesis of verrucarin A (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRotational selectivity in cyclobutene ring openings. Model studies directed toward a synthesis of verrucarin ABarry M. Trost and Patrick G. McDougalCite this: J. Org. Chem. 1984, 49, 3, 458–468Publication Date (Print):February 1, 1984Publication History Published online1 May 2002Published inissue 1 February 1984https://pubs.acs.org/doi/10.1021/jo00177a015https://doi.org/10.1021/jo00177a015research-articleACS PublicationsRequest reuse permissionsArticle Views494Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Robust Ultralow-kDielectric (Fluorocarbon) Deposition by Microwave Plasma-Enhanced Chemical Vapor Deposition (2012)

A robust fluorocarbon film was successfully deposited on a substrate at a temperature above 400 °C by the new microwave plasma-enhanced chemical vapor deposition (MWPE-CVD) method using the linear C5F8 precursor instead of a conventional cyclic C5F8 one. The fluorocarbon performed keeping the dielectric constant low as a value of 2.25 by controlling the molecular structure forming cross-linked poly(tetrafluoroethylene) (PTFE) chains with configurational carbon atoms. The novel fluorocarbon demonstrates less fluorine degassing at an elevated temperature, with high mechanical strength and without degradation of adhesion of the fluorocarbon film to SiCN and SiOx stacked films after thermal stress at 400 °C and 1 atm N2 for 1 h. Consequently, this robust fluorocarbon film is considered a promising candidate for general porous silicon materials with applications to practical integration processes as an interlayer dielectric.
Opposing effects of HLA–DRB1*13 alleles on the risk of developing anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis (2009)

Our findings indicate that the DRB1*13 allele plays a dual role in the development of RA, by protecting against ACPA-positive RA but, in combination with DRB1*03, increasing the risk of ACPA-negative RA.
Molecular beam scattering (1973)

J. C. Polanyi, Faraday Discuss. Chem. Soc., 1973, 55, 389 DOI: 10.1039/DC9735500389
Machine Learning Based Path Planning for Improved Rover Navigation (Pre-Print Version) (2020)

Enhanced AutoNav (ENav), the baseline surface navigation software for NASA's Perseverance rover, sorts a list of candidate paths for the rover to traverse, then uses the Approximate Clearance Evaluation (ACE) algorithm to evaluate whether the most highly ranked paths are safe. ACE is crucial for maintaining the safety of the rover, but is computationally expensive. If the most promising candidates in the list of paths are all found to be infeasible, ENav must continue to search the list and run time-consuming ACE evaluations until a feasible path is found. In this paper, we present two heuristics that, given a terrain heightmap around the rover, produce cost estimates that more effectively rank the candidate paths before ACE evaluation. The first heuristic uses Sobel operators and convolution to incorporate the cost of traversing high-gradient terrain. The second heuristic uses a machine learning (ML) model to predict areas that will be deemed untraversable by ACE. We used physics simulations to collect training data for the ML model and to run Monte Carlo trials to quantify navigation performance across a variety of terrains with various slopes and rock distributions. Compared to ENav's baseline performance, integrating the heuristics can lead to a significant reduction in ACE evaluations and average computation time per planning cycle, increase path efficiency, and maintain or improve the rate of successful traverses. This strategy of targeting specific bottlenecks with ML while maintaining the original ACE safety checks provides an example of how ML can be infused into planetary science missions and other safety-critical software.
The Karlson Lecture. Phytoecdysteroids: What use are they? (2009)

Phytoecdysteroids are analogues of arthropod steroid hormones found in plants, where they deter predation by non-adapted predators. There is potential to exploit this to develop new strategies for pest control, either by using ecdysteroids as lead molecules for the design of novel pest control agents or by alteration of ecdysteroid levels/profiles in crop plants through plant breeding or genetic modification. However, it is other properties of phytoecdysteroids that have led to a rapid recent increase in scientific and commercial interest in these molecules. They are apparently non-toxic to mammals and a wide range of beneficial pharmacological (adaptogenic, anabolic, anti-diabetic, hepatoprotective, immunoprotective, wound-healing, and perhaps even anti-tumour) activities is claimed for them. In particular, this has led to a large (and unregulated) market for ecdysteroid-containing preparations for body-builders, sportsmen, and pets, among others. Ecdysteroids are also being considered as nutraceutical additives to food products. Further, ecdysteroids are good candidates as elicitors for gene-switch systems to be used in medical gene therapy and research applications. In this article, I review the applications of phytoecdysteroids and assess their future potential.
<title>Multilevel volumetric optical storage</title> (1994)

Present optical storage devices use two-dimensional recording media which do not take advantage of the ability to focus light to a small spot at a large working distance throughout the volume of a storage media. In this report we propose an approach to volumetric optical storage where the optical had reads from and writes to distinct levels of a multilevel disk structure. This approach has been successfully applied to multilevel ROM and WORM optical disk memories. We detail the physical principles behind this technology, present detailed experimental data on two-level write-once media and briefly describe four-level recording. In companion papers we describe in detail results from four-level recording and readback and multilevel ROM based media and drives.
Harmonic imaging: a model for ultrasonic speckle reduction (1993)

We present a speckle reduction method called Harmonic Imaging (HI). It is derived from a multi component scattering model for biological tissues. The backscattered ultrasound quadrature signal is modeled as the sum of three components after demodulation. The first component represents nonresolvable diffuse scatterers, the second subresolvable quasiperiodic scatterers, and the third resolvable quasiperiodic scatterers and mirroring surfaces. The HI images produced using radio frequency data from a phantom and from tissues in vivo are more blurred than ordinary envelope images, but the signal to noise ratio and tissue contrast were higher for the HI images
Hermansky-Pudlak Syndrome–Associated Interstitial Pneumonia (2013)

Initially described in 1959, Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by tyrosinase-positive oculocutaneous albinism with a bleeding diathesis. To date, 9 genes have been associated with HPS. The pathogenesis of HPS is thought to be due to disruption in the formation and trafficking of intracellular vesicles including melanosomes, platelet dense granules in platelets, and lysosomes. Late internal manifestations result from the liposomal accumulation of ceroid lipofuscin in macrophages in the lungs, heart, kidneys, and intestines. Hermansky-Pudlak syndrome has an estimated worldwide prevalence of 1:500,000 to 1:1,000,000. However, in Puerto Rico, HPS is the most prevalent single gene disorder with a prevalence as high as 1:1800. Hermansky-Pudlak syndrome typically has a poor prognosis; mortality is usually due to pulmonary fibrosis, which typically manifests in the third to fourth decades with death within a decade.
New insights into the clinical characteristics of SETD2‐mutated acute myeloid leukaemia (2023)

As reported, SETD2 is recurrently mutated in acute myeloid leukaemia (AML), but knowledge about the specifics is limited. We enrolled 530 consecutive newly diagnosed AML patients in our study, and we analysed the distribution pattern and prognostic role of SETD2 mutation in AML. SETD2 mutation was found to affect 6.3% of AML patients, and it frequently co-occurred with IDH2, NRAS and CEBPA mutations. SETD2-mutated patients saw excellent therapeutic responses but failed to gain better survival time than other patients. This could be because of the high recurrence and mortality in SETD2-mutated patients who have additional mutations, such as NRAS mutation.
Cost-effectiveness of cryoballoon ablation for the management of paroxysmal atrial fibrillation (2014)

Cryoballoon ablation provides increased quality-adjusted life expectancy compared with AAD at reasonable additional cost, representing good value for money in patients with PAF.
Ivabradine in treatment of sinus tachycardia mediated vasovagal syncope (2013)

In this pilot study of ivabradine, in patients with VVS, of patients who demonstrated sinus tachycardia before collapse on tilt, 72% reported a marked benefit or complete resolution of symptoms. The drug was well tolerated. A randomized controlled trial against placebo is justified.
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo (1997)

The familial melanoma gene (INK4a/MTS1/CDKN2) encodes potent tumor suppressor activity. Although mice null for the ink4a homolog develop a cancer-prone condition, a pathogenetic link to melanoma susceptibility has yet to be established. Here we report that mice with melanocyte-specific expression of activated H-rasG12V on an ink4a-deficient background develop spontaneous cutaneous melanomas after a short latency and with high penetrance. Consistent loss of the wild-type ink4a allele was observed in tumors arising in ink4a heterozygous transgenic mice. No homozygous deletion of the neighboring ink4b gene was detected. Moreover, as in human melanomas, the p53 gene remained in a wild-type configuration with no observed mutation or allelic loss. These results show that loss of ink4a and activation of Ras can cooperate to accelerate the development of melanoma and provide the first in vivo experimental evidence for a causal relationship between ink4a deficiency and the pathogenesis of melanoma. In addition, this mouse model affords a system in which to identify and analyze pathways involved in tumor progression against the backdrop of genetic alterations encountered in human melanomas.
A Compact Low Loss Single-Ended to Two-Way Differential Power Divider/Combiner (2015)

This letter presents the analysis and design of a novel compact single-ended to two-way differential passive power divider/combiner using coupled lines. A model for the power combiner/divider is proposed and verified using electromagnetic simulations and measurements. The coupled line power combiner (CLPC) is designed at 5 GHz center frequency and fabricated on a standard 4-layer FR-4 printed circuit board. The combiner core has dimensions of 4.1 × 8.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Measurement results show an input matching below -10 dB from 3 to 6 GHz, and an insertion loss less than 0.5 dB over the same frequency range. The amplitude mismatch between the output ports is less than 0.5 dB, and the phase mismatch is less than five degrees.