gebhart/patrepeval huggingface dataset:
Gum arabic–acrylic superabsorbing hydrogel hybrids: Studies on swelling rate and environmental responsiveness (2006)

Abstract The swelling rate and the environmental sensitivity of novel superabsorbent gum arabic–acrylic hydrogel hybrids were investigated. The swelling kinetics of the hydrogel hybrids was studied by means of a Voigt‐based viscoelastic model. The effects of concentration of the initiator, crosslinker, and the monomer ratio on the swelling rate were studied. The superswelling properties of the hydrogel hybrids were evaluated in various environmental pH, salinity and solvent–water mixtures. The optimally prepared hydrogel, MR5, showed a reproducible on–off switching behavior when the swelling medium was alternatively changed between distilled water and alkaline solutions. The hydrogel hybrid MR5 was also tested to be swollen and deswollen alternatively in distilled water and sodium chloride solution. The sorption–desorption behavior was found to be quite repeatable. A similar capability was interestingly observed when a calcium chloride solution with the same molar concentration was used. The swelling changes of the hydrogel hybrid were examined in various water–solvent systems including the aqueous solutions of methanol, ethanol, acetone, ethylene glycol, glycerol, and dimethylsulfoxide. One and/or two volume‐phase transitions were induced by the nonsolvents. The transitions were explained according to the solubility parameters of the solvents and water–solvent mixtures. The swelling–deswelling capability of the hydrogel in alternatively changed solvent–water mixtures was also studied. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 5667–5674, 2006
Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations (2013)

The persistence leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) despite tyrosine kinase inhibition (TKI) may explain relapse after TKI withdrawal. Here we performed genome-wide transcriptome analysis of highly refined CML and normal stem and progenitor cell populations to identify novel targets for the eradication of CML LSCs using exon microarrays. We identified 97 genes that were differentially expressed in CML versus normal stem and progenitor cells. These included cell surface genes significantly upregulated in CML LSCs: DPP4 (CD26), IL2RA (CD25), PTPRD, CACNA1D, IL1RAP, SLC4A4, and KCNK5. Further analyses of the LSCs revealed dysregulation of normal cellular processes, evidenced by alternative splicing of genes in key cancer signaling pathways such as p53 signaling (e.g. PERP, CDKN1A), kinase binding (e.g. DUSP12, MARCKS), and cell proliferation (MYCN, TIMELESS); downregulation of pro-differentiation and TGF-β/BMP signaling pathways; upregulation of oxidative metabolism and DNA repair pathways; and activation of inflammatory cytokines, including CCL2, and multiple oncogenes (e.g., CCND1). These data represent an important resource for understanding the molecular changes in CML LSCs, which may be exploited to develop novel therapies for eradication these cells and achieve cure.
Molecular characterization of the mouse vesicular acetylcholine transporter gene (1997)

The organization of the mouse choline acetyltransferase (ChAT) gene has been previously analyzed. Here we show that the first intron of the mouse ChAT gene contains an uninterrupted open reading frame. It is in the same transcriptional orientation as ChAT and encodes the vesicular acetylcholine (ACh) transporter (VAChT), the protein responsible for the translocation of cytoplasmic ACh into synaptic vesicles. The sequence of this transporter is very similar to the VAChT from rat and human (99% and 95% identity, respectively). Reverse transcription-polymerase chain reaction (RT-PCR) analysis showed expression of mouse VAChT mRNA in spinal cord, brain (excluding the cerebellum) and brain stem, but not in peripheral tissues such as liver and kidney. Transgenic mouse analysis revealed that the 5'-flanking region of the mouse ChAT gene encompasses regulatory elements that allowed elevated expression of VAChT in the cholinergic system of transgenic mice.
Adoptive transfer of a novel MIF receptor (CD74+) expressing memory T cell subpopulation is sufficient to transfer inflammatory arthritis (2017)

Abstract Rheumatoid arthritis (RA) is characterized by relapsing disease and progressive autoimmune joint destruction. The mechanism(s) for disease recurrence in previously affected joints is unknown. High expression alleles of the cytokine macrophage migration inhibitory factor (MIF) are associated with severe erosive RA. We report a novel subpopulation of T cells expressing the MIF receptor CD74, which previously has not been considered to be present in T lineage cells. CD74+ T cells comprise 1% of lymph node T cell and exhibit an effector memory phenotype (CD3+ CD74+ CD44+, CD62Llow). Notably, whole genome expression profiling (RNAseq) of CD74+ T cells revealed reduced expression of the immune checkpoint Ctla4 (3.5-fold, p=0.009), and increased expression of Stat4 and Ptpn22 (1.4-fold, p=0.001 and 0.86-fold, p=0.045), three genes that regulate T cell activation and also are linked genetically to RA pathogenesis. In the collagen-induced arthritis (CIA) mouse model of RA, we observed a 2-fold (p=0.023) expansion of CD74+ T cells after disease induction when compared to Mif−/− mice, which show no expansion of CD74+ T cells and reduced disease severity (disease score: WT: 7.8; Mif −/−: 1.4, p&amp;gt;0.001). Notably, adoptive transfer of CD74+ T cells from mice with established CIA into naive mice recapitulated joint inflammation (disease score: 4.3, p=0.001). Disease was not detectable in naïve mice that received CD74-T cells from CIA hosts. This study identifies a novel population of effector memory T cells that are capable of transferring autoimmune joint inflammation. We hypothesize that MIF responsive CD74+ effector memory T cells mediate recurrent joint inflammation and may be amenable to specific targeting by emerging MIF-directed therapies.
Protective effects of Amaranthus hybridus against aflatoxin B1and fumonisin B1-induced genotoxicity in H4IIE-luc cells (2015)

Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination and early diagnosis of hepatoma, complications of hepatoma, and their preventions and treatments, etc.
3D Concentric Electrodes-Based Alternating Current Electrohydrodynamics: Design, Simulation, Fabrication, and Potential Applications for Bioassays (2022)

Two-dimensional concentric asymmetric microelectrodes play a crucial role in developing sensitive and specific biological assays using fluid micromixing generated by alternating current electrohydrodynamics (ac-EHD). This paper reports the design, simulation, fabrication, and characterization of fluid motion generated by 3D concentric microelectrodes for the first time. Electric field simulations are used to compare electric field distribution at the electrodes and to analyze its effects on microfluidic micromixing in 2D and 3D electrodes. Three-dimensional devices show higher electric field peak values, resulting in better fluid micromixing than 2D devices. As a proof of concept, we design a simple biological assay comprising specific attachment of streptavidin beads onto the biotin-modified electrodes (2D and 3D), which shows ~40% higher efficiency of capturing specific beads in the case of 3D ac-EHD device compared to the 2D device. Our results show a significant contribution toward developing 3D ac-EHD devices that can be used to create more efficient biological assays in the future.
Pedometer-Measured Physical Activity and Health Behaviors in U.S. Adults (2010)

In the current study, men and women living in the United States took fewer steps per day than those living in Switzerland, Australia, and Japan. We conclude that low levels of ambulatory physical activity are contributing to the high prevalence of adult obesity in the United States.
ATP-Induced Mucin Release from Cultured Airway Goblet Cells Involves, in Part, Activation of Protein Kinase C (1997)

Extracellular nucleotides stimulate mucin release by binding to the P2u receptor coupled to phospholipase C via G proteins (Br. J. Pharmacol. 103:1053-1056, 1991; Am. J. Respir. Cell Mol. Biol. 8:121-125, 1993). In the present study, we intended to investigate pathways downstream to the phospholipase C activation which is responsible for adenosine triphosphate (ATP)-induced mucin release in hamster tracheal epithelial cells in primary culture. We have found that: (1) Ca2+ ionophores (A23187 and ionomycin) did not affect mucin release even at 1 microM; (2) thapsigargin (10 microM), either alone or in combination with ATP (20 microM), did not enhance mucin release over its respective control group; (3) pretreatment of hamster tracheal surface epithelial (HTSE) cells with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid-acetoxymethyl ester (BAPTA-AM) (50 microM) did not inhibit ATP-induced mucin release; (4) 4beta-phorbol 12alpha-myristate 13-acetate (PMA, 1 microM) stimulated mucin release and its effect was completely blocked by protein kinase C inhibitors such as sphingosine (10 microM) and calphostin C (0.1 microM), whereas ATP-induced mucin release was blocked, only in part, by these inhibitors; (5) desensitization of protein kinase C by pretreatment with PMA inhibited the PMA-induced mucin release completely, however, ATP-induced mucin release was inhibited only partially. We conclude that mucin release by ATP does not require an increase in the intracellular Ca2+ level but involves the activation of protein kinase C. The results also suggest the presence of another mechanism separate from the phospholipase C-protein kinase C pathway for the ATP-induced mucin release.
A Degenerate HLA-DR Epitope Pool of HER-2/neu Reveals a NovelIn vivoImmunodominant Epitope, HER-2/neu88-102 (2010)

The broad coverage and natural immunity to this epitope pool suggests potential usefulness in HER-2/neu-targeting, immune-based therapies such as vaccines.
The Physics of Low-dimensional Semiconductors (1997)

The composition of modern semiconductor heterostructures can be controlled precisely on the atomic scale to create low-dimensional systems. These systems have revolutionised semiconductor physics, and their impact on technology, particularly for semiconductor lasers and ultrafast transistors, is widespread and burgeoning. This book provides an introduction to the general principles that underlie low-dimensional semiconductors. As far as possible, simple physical explanations are used, with reference to examples from actual devices. The author shows how, beginning with fundamental results from quantum mechanics and solid-state physics, a formalism can be developed that describes the properties of low-dimensional semiconductor systems. Among numerous examples, two key systems are studied in detail: the two-dimensional electron gas, employed in field-effect transistors, and the quantum well, whose optical properties find application in lasers and other opto-electronic devices. The book includes many exercises and will be invaluable to undergraduate and first-year graduate physics or electrical engineering students taking courses in low-dimensional systems or heterostructure device physics.
A Pulse Area Analyzer (PAA) for High Resolution Gamma Ray Spectroscopy (1974)

A different type multichannel analyzer has been designed, built, and tested for the High Spectral Resolution Gamma Ray Spectrometer to be flown on the HEAO spacecraft. This system offers superior dynamic range, energy conversion, and stability for large Ge(Li) detectors. Theoretical and measured results from an 8192 channel analyzer are presented.
A spatial model of the red queen effect (2007)

Van Valen first discovered the "Red Queen Effect" (RQE), where two species can dramatically co-evolve their phenotypes over time but never gain a relative advantage [2]. In the ideal version of the RQE, regardless of the actual values that the species evolve to obtain, they have not moved in relation to each other. Though previous models of the RQE exist, we developed an agent-based model (ABM) which has a base ontology more similar to real world coevolutionary systems than equation-based models (EBMs). For instance, this model contains spatial information and an individuallevel reproduction mechanism. Yet this model recreates traditional EBM results. For instance Dieckmann et al show that there are three possible outcomes of competitive coevolution: predator dominance, prey dominance and evolutionary cycling (RQE) [1]. By reconceptualizing this EBM using an ABM, we make it easier for students and researchers to understand, manipulate, and modify this model [4]. The model is written in the NetLogo agent-based modeling environment [3]. The model is initialized with 150 predator and 150 prey agents. Predator agents have a resistance level r and prey agents have a poison p. The agents are initially randomly distributed on a toroidal real-valued 35 by 35 grid. The initial resistance and poison values for the predators and prey are drawn from normal distributions with means µr and µp and a standard deviation of 1. During a model timestep, each agent moves one unit at a random heading. If at the end of its move a predator is within 1 unit of a prey, then it will challenge the prey. The predator will compare its resistance value to the prey's poison value and which ever agent has the larger value will win the challenge and the other agent will be killed. At the end of an agent's turn if the total number of agents is less than the maximum carrying capacity the agent will reproduce with a 50% probability. The new agent's initial poison / resistance will be drawn from a normal distribution with the parent's poison / resistance as the mean value and a standard deviation of 1.
Characterization of Anodized Titanium Oxide Film and Photocatalytic Decomposition of Methylene Blue with Microcurrent (2007)

Abstract Sol-gel coating that is commonly used in photocatalyst immobilization has low binding capacity with supporting materials and low photocatalytic efficiency due to reduction of surface area of catalysts. In addition, the recombination of electrons and holes is an important reason of low efficiency in photocatalytic reaction. To solve such problems, our study devised a TiO
Photosensitization of carbon nanotubes using dye aggregates (2011)

Ordered assemblies of dye molecules, dye aggregates, possess significantly larger molar optical absorptivity than dye monomers. Yet, aggregates have not been utilized for photosensitizing nanoscale electronic devices. We find that single-walled carbon nanotubes, which are cleaned down to the atomic scale, template the growth of squaraine dye aggregates and these aggregates effectively photosensitize nanotubes. Templating of aggregates by nanotubes and functionalization of nanotubes with ordered molecular films are reported for the first time. The sensitivity achieved by aggregate-functionalized nanotube network devices is approximately an order of magnitude better than those of similar nanotube devices functionalized with dye monomers and photoactive polymers.
Arrays of microdischarge devices having 50–100µm squarepyramidal Si anodes and screen cathodes (2001)

Microdischarge devices having (50–100 µm)2 pyramidal Si anodes and metal screen cathodes have been operated continuously at Ne gas pressures up to 1350 Torr and voltages below 95 V. More than 34 µW of output power is produced by a single device in a solid angle of ~5 × 10-2 sr for a Ne pressure of 500 Torr. 3 × 3 arrays of these devices have been fabricated.
Learning to Predict Trustworthiness with Steep Slope Loss (2021)

Understanding the trustworthiness of a prediction yielded by a classifier is critical for the safe and effective use of AI models. Prior efforts have been proven to be reliable on small-scale datasets. In this work, we study the problem of predicting trustworthiness on real-world large-scale datasets, where the task is more challenging due to high-dimensional features, diverse visual concepts, and large-scale samples. In such a setting, we observe that the trustworthiness predictors trained with prior-art loss functions, i.e., the cross entropy loss, focal loss, and true class probability confidence loss, are prone to view both correct predictions and incorrect predictions to be trustworthy. The reasons are two-fold. Firstly, correct predictions are generally dominant over incorrect predictions. Secondly, due to the data complexity, it is challenging to differentiate the incorrect predictions from the correct ones on real-world large-scale datasets. To improve the generalizability of trustworthiness predictors, we propose a novel steep slope loss to separate the features w.r.t. correct predictions from the ones w.r.t. incorrect predictions by two slide-like curves that oppose each other. The proposed loss is evaluated with two representative deep learning models, i.e., Vision Transformer and ResNet, as trustworthiness predictors. We conduct comprehensive experiments and analyses on ImageNet, which show that the proposed loss effectively improves the generalizability of trustworthiness predictors. The code and pre-trained trustworthiness predictors for reproducibility are available at https://github.com/luoyan407/predict_trustworthiness.
Intercalation of Salts of Fatty Acids into Kaolinite (1990)

Abstract Intercalation of sodium and potassium salts of lauric, myristic, palmitic, elaidic, oleic, 12-hydroxystearic, and a blend of C 8 –C 10 acids in kaolinite has been followed by X-ray powder diffraction, nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy, and thermal studies. The 7-Å ‘c’ axis spacing in kaolinite expands to 11 Å as a result of intercalation; this expansion is independent of the alkyl chain length of the fatty acid. The orientation of the organic molecules in the kaolinite interlayer is nearly flat, and 1 H NMR indicates an enhanced ordering in the potassium laurate intercalate. The reversal or equalization of the relative intensities of hydroxyl bands at 3696 and 3619 cm -1 of kaolinite are related to the phenomenon of intercalation. The decomposition temperature of these salts decreases when they are intercalated in kaolinite.
Dual-Carrier Process Using Mechanical and Laser Release Technologies for Advanced Wafer-Level Packaging (2018)

Temporary bonding and debonding (TBDB) techniques have been adopted for use in large-scale manufacturing and are an integral part of 3-D integration. Today's advance Wafer Level Packaging (WLP) processes are complex and evolving, driven by increasing demand for higher performance packages. A dual-carrier bonding process allows users to temporarily bond a device substrate to a carrier, perform backside processing, flip the substrate and bond a second carrier, then selectively debond from the original carrier. This process maintains structural support for the thinned wafer while it undergoes further downstream processes. The use of adhesive and release materials that have different bonding and debonding properties makes a dual-carrier process attractive for complex 3D stacked IC integration. In this study, multiple bonding and release materials will be evaluated using a dual-carrier bonding process. Various types of substrates will also be used to further characterize this process. Bond quality, ease of release and material cleaning will be evaluated for both mechanical release and laser ablation technologies.
Magnetic Proximity Effect and Interlayer Exchange Coupling of Ferromagnetic/Topological Insulator/Ferromagnetic Trilayer (2014)

Magnetic proximity effect between topological insulator (TI) and ferromagnetic insulator (FMI) is considered to have great potential in spintronics. However, a complete determination of interfacial magnetic structure has been highly challenging. We theoretically investigate the interlayer exchange coupling of two FMIs separated by a TI thin film, and show that the particular electronic states of the TI contributing to the proximity effect can be directly identified through the coupling behavior between two FMIs, together with a tunability of coupling constant. Such FMI/TI/FMI structure not only serves as a platform to clarify the magnetic structure of FMI/TI interface, but also provides insights into designing the magnetic storage devices with ultrafast response.
Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells (2014)

Excessive lipid accumulation in the liver has been proposed to cause hyperlipidemia, diabetes and fatty liver disease. 4-Hydroxyderricin (4HD), xanthoangelol (XAG), cardamonin (CAR) and flavokawain B (FKB) are chalcones that have exhibited various biological effects against obesity, inflammation, and diabetes; however, little is known about the inhibitory effects of these chalcones on fatty liver disease. In the present study, we investigated the ability of 4HD, XAG, CAR, and FKB to reduce lipid accumulation in hepatocytes. When HepG2 cells were treated with a mixture of fatty acids (FAs; palmitic acid : oleic acid = 1 : 2 ratio), significant lipid accumulation was observed. Under the same experimental conditions, addition of chalcones at 5 μM significantly suppressed the FA-induced lipid accumulation. We found that the expression of sterol regulatory element-binding protein-1 (SREBP-1), a key molecule involved in lipogenesis, was decreased in these chalcone-treated cells. We also found that these chalcones increased the expression of peroxisome proliferator-activated receptor α (PPARα), which is involved in FA oxidation. Moreover, these chalcones increased phosphorylation of AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), upstream regulators of SREBP-1 and PPARα. We confirmed that an AMPK inhibitor, compound C, reversed chalcone-induced changes in SREBP-1 and PPARα expression in the HepG2 cells. Collectively, we found that 4HD, XAG, CAR, and XAG attenuated lipid accumulation through activation of the LKB1/AMPK signaling pathway in HepG2 cells.
The influence of surfactants on growth modes in molecular-beam epitaxy: The growth of germanium layers on Si(100) (1992)

Up to 30 nm thick Ge layers were grown on Si(100) by using Sb as a surfactant and were investigated by reflection high-energy electron diffraction, x-ray photoelectron spectroscopy, secondary ion mass spectroscopy, transmission electron microscopy, and confocal laserscan microscopy. The introduction of a surfactant alters the growth mode drastically from a three-dimensional clustering mechanism to a two-dimensional layer-by-layer growth. Smooth and strained Ge layers, with a thickness much larger then the critical thickness for commensurate growth, are achievable. The antimony monolayer mainly segregates on top of the grown germanium layer.
All-optical TDM-to-WDM data format conversion in a dynamically reconfigurable WDM network (1995)

We demonstrate both single-stage and two-stage all-optical TDM-to-WDM data format convertors based on cross-gain compression in an SOA. Our method simultaneously time demultiplexes and wavelength shifts each channel's data within a TDM packet. We convert a 2-Gb/s 4-channel TDM data stream at 1552 mn into four 500-Mb/s WDM channels at 1535, 1537, 1540, and 1571 mm. Moreover, we extend this single-stage approach by demonstrating a two-stage TDM-to-WDM convertor that selectively time demultiplexes and wavelength shifts a 2-Gb/s TDM input data stream into two 500-Mb/s WDM channels after the second stage. We find that low power penalties (<2 dB) can be achieved by using this scheme for both the single- and two-stage cases. This conversion scheme may be quite useful in WDM switching nodes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>