gebhart/patrepeval huggingface dataset:
Isolated anti-Ku antibody in scleroderma-myositis overlap syndrome: the histo-pathological patern (2012)

An 18-years old African girl, suffered for almost 4 years of polyarthralgia, joint contractures and a hardcover appearance of the skin suggestive of scleroderma. The clinical picture and a high level of CPK suggested Polymyositis (PM).

Search for anti nuclear Antibody (ANA) showed speckled pattern at 1/2500 titre, and subscreening revealed isolated anti-Ku antibody. This was more often reported in association with PM - SSc overlap syndrome.

Skin biopsy favored linear scleroderma.

Interestingly, muscle biopsy showed features typical of dermatomyositis (DM).

No endocrine disorder or underlying mitotic process was registered.

Corticosteroid therapy was initiated followed by maintenance therapy with methotrexate; the outcome was favorable.

This case illustrates the interest of anti-Ku screening in the diagnostic work-up. Our observation thus emphasizes the possible occurrence of isolated anti-Ku antibody expression in an overlap syndrome comprising SSc-DM association. Such association/linkage (implicating DM rather than PM) is, to our knowledge, very rarely well reported. Moreover, the therapeutic response seems favorable in such condition.

We found one biopsy-confirmed observation of SSc-Inflammatory myositis (IM) overlap syndrome in an anti-Ku positive patient [1,2]. This later case was initially reported as SSc-PM overlap syndrome. Interestingly, follow-up showed evolution towards typical features of DM, and hence an overlap syndrome of SSc-DM association.

Thus, our observation highlights the necessity/interest of biopsy to ascertain the precise nature of myositis in an overlap syndrome associating SSc and Myositis Clinico-pathological criteria in inflammatory myositis have been reviewed by Cherin P et al., [3].

Anti-ku Ab is knowingly reported in a context of myositis. Thus our observation and review of the literature suggest that in the presence of isolated anti-Ku Ab in a SSc-Myositis overlap context, muscle biopsy (that should be done) would tend to show DM (rather than PM) in association with the SSc. Such a finding may change the prognosis and the treatment approach of this syndrome. This can only be demonstrated after elaborate muscle biopsy in overlap syndromes, with or without the presence of anti-Ku antibodies.
The design and combustion performance of practical swirlers for integral rocket/ramjets (1983)

A method was devised for the design and fabrication of swirl inlet hardware with practical application to the integral rocket/ramjet dump combustor. A total of seven swirl inserts were tested to determine the effects of different swirl profiles on combustor performance. Combustor length-to-diameter ratio (LC/D) was varied between 1.5 and 3, and the ratio of the nozzle throat to combustor area (A*/A3) between 40 and 60%. Combustor wall static distributions were measured in all configurations in which LC/D = 3. Airflow immediately downstream of the swirler was probed in cold flow to determine actual swirl angles to compare with prediction. Combustion instability data was recorded for subsequent spectral analysis by fast Fourier transform.
A reproducible technique for specific labeling of antigens using preformed fluorescent molecular IgG‐F(ab′)2 complexes from primary antibodies of the same species (2009)

Immunolabeling two different antigens using the indirect approach with antibodies from the same species is not possible as secondary antibodies can bind to either primary target antibodies. In this study, we describe how preformed complexes of primary and secondary labeled antibodies can be used in such circumstances. In this situation, the first antigen is labeled using the conventional indirect method followed by incubation with the preformed primary-secondary antibody complex against the second antigen. To prevent unbound secondary antibody from binding the indirectly-labeled antibodies, resulting in a false positive, we quenched excess secondary antibody with nonimmune murine serum from the species of the primary antibody. Before the formation of the preformed complex, the optimum dilution of both primary and secondary antibodies was determined. Once these concentrations were established, the concentration of nonimmune murine serum required to quench excess unbound secondary was determined. This step was accomplished by first incubating the sample with an antibody against an antigen known to be localized away from the antigen of interest, followed by the preformed complex. If specific staining was seen, other than that expected from the preformed complex, then the concentration of the serum was deemed insufficient for quenching, and increased accordingly. We demonstrate that this approach is successful in determining the optimum conditions for the preformation of ascites and purified monoclonal primary IgG with fluorescently conjugated F(ab')(2). Double immunolabelling of two focal adhesion antigens and two cytoskeletal proteins, with two murine primary antibodies, are presented as examples of the methodology.
Microbial Glucoamylases: Biochemical and Biotechnological Features (1989)

Abstract Glucoamylase is one of the most important industrial enzymes and has a world wide application. A comprehensive review of microbial glucoamylase, its production, multiplicity, molecular characteristics, action on soluble and insoluble substrates and industrial usefulness is presented.
Molecules and Mechanisms of Mechanotransduction (2004)

To many animals, including humans, some of the best things in life are mechanical. Not only courtship and sex but also simple movements such as walking depend on the ability to transform mechanical energy in the form of touch, sound, and muscle tension into ionic currents. This ability is also
Sequence variation in PPP 1R13L results in a novel form of cardio‐cutaneous syndrome (2017)

Dilated cardiomyopathy (DCM) is a life-threatening disorder whose genetic basis is heterogeneous and mostly unknown. Five Arab Christian infants, aged 4-30 months from four families, were diagnosed with DCM associated with mild skin, teeth, and hair abnormalities. All passed away before age 3. A homozygous sequence variation creating a premature stop codon at <i>PPP1R13L</i> encoding the iASPP protein was identified in three infants and in the mother of the other two. Patients' fibroblasts and <i>PPP1R13L</i>-knocked down human fibroblasts presented higher expression levels of pro-inflammatory cytokine genes in response to lipopolysaccharide, as well as <i>Ppp1r13l</i>-knocked down murine cardiomyocytes and hearts of <i>Ppp1r13l</i>-deficient mice. The hypersensitivity to lipopolysaccharide was NF-κB-dependent, and its inducible binding activity to promoters of pro-inflammatory cytokine genes was elevated in patients' fibroblasts. RNA sequencing of <i>Ppp1r13l</i>-knocked down murine cardiomyocytes and of hearts derived from different stages of DCM development in <i>Ppp1r13l</i>-deficient mice revealed the crucial role of iASPP in dampening cardiac inflammatory response. Our results determined <i>PPP1R13L</i> as the gene underlying a novel autosomal-recessive cardio-cutaneous syndrome in humans and strongly suggest that the fatal DCM during infancy is a consequence of failure to regulate transcriptional pathways necessary for tuning cardiac threshold response to common inflammatory stressors.
The assessment of postural control and the influence of a secondary task in people with anterior cruciate ligament reconstructed knees using a Nintendo Wii Balance Board (2012)

Background Postural control impairments may persist following anterior cruciate ligament (ACL) reconstruction. The effect of a secondary task on postural control has, however, not been determined. The purpose of this case–control study was to compare postural control in patients following ACL reconstruction with healthy individuals with and without a secondary task. Participants 45 patients (30 men and 15 women) participated at least 6 months following primary ACL reconstruction surgery. Participants were individually matched by age, gender and sports activity to healthy controls. Materials Postural control was measured using a Nintendo Wii Balance Board and customised software during static single-leg stance and with the addition of a secondary task. The secondary task required participants to match the movement of an oscillating marker by adducting and abducting their arm. Main outcome measures Centre of pressure (CoP) path length in both medial-lateral and anterior–posterior directions, and CoP total path length. Results When compared with the control group, the anterior–posterior path length significantly increased in the ACL reconstruction patients' operated (12.3%, p=0.02) and non-operated limbs (12.8%, p=0.02) for the single-task condition, and the non-operated limb (11.5%, p=0.006) for the secondary task condition. The addition of a secondary task significantly increased CoP path lengths in all measures (p&lt;0.001), although the magnitude of the increase was similar in both the ACL reconstruction and control groups. Discussion ACL reconstruction patients showed a reduced ability in both limbs to control the movement of the body in the anterior–posterior direction. The secondary task affected postural control by comparable amounts in patients after ACL reconstruction and healthy controls. Devices for the objective measurement of postural control, such as the one used in this study, may help clinicians to more accurately identify patients with deficits who may benefit from targeted neuromuscular training programs.
A Double-Blind Non-Crossover Placebo-Controlled Study between Group Comparison of Trazodone and Amitriptyline on Cardiovascular Function in Major Depressive Disorder (1984)

The cardiovascular effects of trazodone ( TZD ), amitriptyline (AMT) and placebo were studied in out-patients with major depression. AMT was shown to have the expected effects on the electrocardiograph and on systolic time intervals consistent with its proven anticholinergic and quinidine-like properties. TZD , in contrast, had no quinidine-like effects and minor effects on systolic time intervals. However, it was not without any cardiovascular effects. Although TZD was shown to be a safer preparation than the reference drug AMT, long-term monitoring is needed to explain the minor effect on heart rate and T wave changes.
LifeBrush: Painting Interactive Agent-Based Simulations (2018)

Building and interacting with 3D agent-based simulations that contain a large number of agents is a significant challenge. What if we want to create an intricate new arrangement of agents, or reconfigure a large number of agents? We present LifeBrush, a cyberworld for interactively painting large and elaborate multi-agent simulations with commodity virtual reality systems that we can then simulate and explore. Our main methodology uses sketch-based discrete element texture synthesis to paint agent arrangements. We define a map to convert agents to elements in this framework when we paint and back to agents when we simulate. Like creating new colors on a paint palette, we create example agent arrangements and configurations in an example palette. We paint new agents into a scene with sketch-based generative brushes. We also use those brushes to reconfigure agents to match examples created in the palette. Then we simulate, pause the simulation and modify the agents with our sketch-based tools. This iteration loop enables new levels of interactivity for the design, simulation, and exploration of agent-based simulations.
Estudo de estratégias de controle de estoque com otimização via algoritmos genéticos (2013)

Uma questao importante para a logistica empresarial e a administracao de centrais de
estoque. Como aumentar a produtividade e, principalmente, o lucro por meio de uma gestao
otimizada desse componente chave em diversos seguimentos industrio-comerciais?
Esse texto se dedica ao estudo de uma cadeia de suprimentos simples sujeita a diferentes
estrategias de controle sempre visando sua gestao de forma otima.
O objetivo desse trabalho e a avaliacao de diferentes estrategias de controle que otimizem
o EVA (Economic Value Added) de um sistema de gestao de estoque ao final do periodo de um
ano. Para tanto,as estrategias estudadas sao analisadas por meio de simulacoes realizadas em
plataforma MATLAB.
Sao analisados controladores PID e com Logica Fuzzy . A demanda e estimada a partir de
sistemas de suavizacao exponencial simples e o metodo de otimizacao escolhido e o Algoritmo
Genetico.
Tune-stabilized linear-field FFAG for carbon therapy (2006)

A hybrid design for a Fixed-Field Alternating-Gradient (FFAG) accelerator has been invented which uses edge and alternating-gradient focusing principles applied in a specific configuration to a combined-function magnet to stabilize tunes through an acceleration cycle which extends over a factor of 2-6 in momentum. Using normal conducting magnets, the final, extracted energy from this machine attains 400 MeV/nucleon and thus supports a carbon ion beam in the energy range of interest for cancer therapy. Competing machines for this application include superconducting cyclotrons[1], synchrotrons[2], and, more recently, scaling FFAGs. The machine proposed here has the high average current advantage of the cyclotron with smaller radial aperture requirements that are more typical of the synchrotron; and as such represents a desirable innovation for therapy machines.
Hydrodynamics and mass transfer characteristics of a scheibel extractor. Part II: Backmixing and stage efficiency (1985)

Abstract The transfer of acetone between the toluene phase (dispersed) and the aqueous phase (continuous) has been measured along the length of a four‐stage Scheibel column packed with material preferentially wetted by the dispersed phase. (A Scheibel stage is defined as one mixing section plus one packing section.) The column concentration profiles were obtained by applying a new technique developed for this investigation. A parameter model‐fitting exercise has been developed to select the most appropriate mathematical model that quantifies the extent of backmixing in the dispersed and continuous phases and evaluates the stage efficiency. Overall dispersed phase mass transfer coefficients were estimated using the drop size and holdup data presented in Part I, and these have been compared with the published correlations based on single drop mechanisms.
A New Perspective on Anhedonia in Schizophrenia (2012)

The authors conclude that anhedonia should no longer be considered an experiential deficit or a diminished "capacity" for pleasure in patients with schizophrenia. Rather, anhedonia reflects a set of beliefs related to low pleasure that surface when patients are asked to report their noncurrent feelings. Encoding and retrieval processes may serve to maintain these beliefs despite contrary real-world pleasurable experiences. Implications for assessment and treatment are discussed in relation to this new conceptualization of anhedonia.
Haze‐Active Protein and Polyphenols in Apple Juice Assessed by Turbidimetry (1997)

ABSTRACT The amount of haze‐active protein in apple juice was determined by adding tannic acid to induce haze followed by turbidimetry. Turbidity was essentially linear with protein concentration. PVPP treatment prior to tannic acid addition appeared to remove endogenous polyphenols and resulted in slightly weaker response. Adding gelatin to apple juices or clarified ciders induced hazes in response to content of haze‐active polyphenols. At an appropriate gelatin concentration turbidity was nearly linear with polyphenol concentration. Treatment with bentonite prior to gelatin addition appeared to remove endogenous protein. Temperature control during the induction period was critical to reproducibility.
4.O.06 EXTRA-ARTICULAR BONE- OR SOFT TISSUE TUMOUR RESECTION OF THE KNEE JOINT; RESULTS IN 34 PATIENTS (2010)

Limb-sparing surgery has become the preferred surgical treatment of malignant bone tumours of the knee. In patients with intra-articular extension of their tumour, extra-articular limb sparing surgery can prevent the knee from amputation. In a retrospective study between January 1985 and December 2007, we performed 34 extra-articular tumour resections of the knee-joint for a bone- or soft tissue tumour in the distal femur or proximal tibia with (suspect) intra-articular tumour extension into the knee on MRI. Contra-indications were extension of the tumour into the extensor mechanism and/or tumour involvement of the neurovascular bundle. Osteosarcoma (23/34) was the most common primary malignancy. Mean age was 36 years (17–70) and the mean follow up was 9 years (1–19). Patient survival rates at 5 years and 10 years are 78% and 58% respectively, mean patient survival was 47 months (8–211). In 12 (35%) patients, the primary implanted prosthesis failed during follow up. Prosthetic survival rates including minor revision surgery were 63% at 5 years and 36% at 10 years. Six (18%) patients had local recurrence of their malignancy, 5 of them in the popliteal fossa. Local recurrence was significantly correlated with marginal margins (P Our results suggest that extra-articular tumour resections of the knee-joint can provide a functional endoprosthesis and can be an alternative for primary amputation. However it is a technical demanding procedure with acceptable local recurrence and high complication rates in patients with, in general, poor survival.
Enabling Micro-payments on IoT Devices using Bitcoin Lightning Network (2021)

Lightning Network (LN) addresses the scalability problem of Bitcoin by leveraging off-chain transactions. Nevertheless, it is not possible to run LN on resource-constrained IoT devices due to its storage, memory, and processing requirements. Therefore, in this paper, we propose an efficient and secure protocol that enables an IoT device to use LN's functions through a gateway LN node. The idea is to involve the IoT device in LN operations with its digital signature by replacing original 2-of-2 multisignature channels with 3-of-3 multisignature channels. Our protocol enforces the LN gateway to request the IoT device's cryptographic signature for all operations on the channel. We evaluated the proposed protocol by implementing it on a Raspberry Pi for a toll payment scenario and demonstrated its feasibility and security.
극한값으로부터의 최적화를 이용한 그루브를 통한 표면형상변형 동특성 변경법 검증 (2009)

구조물 동특성 변경법이란 부가 구조물의 첨가나 삭제, 재료 물성치의 변경, 구조물의 형상변경 등을 이용해 구조물의 동특성을 향상시킬 수 있는 매우 효과적인 방법이다. 하지만 이러한 구조물 동특성 변경법 중 구조물의 형상 변경을 통해 그 구조물의 동특성을 향상시키는 방법은 지금까지는 주로 엔지니어의 경험이나 많은 시간을 요하는 시행착오법에 의존해 왔다. 따라서, 앞선 연구를 통해 이러한 구조물의 형상 변경을 통한 동특성변경법에 있어서 기존의 경험이나 시행착오법에 의존하는 방법이 아닌, 체계화된 방법론을 제안하게 되었으며 하드디스크 드라이브(HDD)에 성공적으로 적용하였다. 제안된 그루브를 통한 표면형상변형 동특성변경법을 검증해 보기 위하여, 본 연구에서는 모든 요소가 엠보싱 되어 있는 극한의 경우로부터 최적화를 수행하고 앞선 연구에서 얻어진 최적화 결과와 비교함으로써 제안된 방법론의 효과를 검토해 볼 수 있었으며, 1차 고유진동수를 높이기 위한 최적화 결과 그루브의 형상은 앞선 연구결과와 같음을 알 수 있었다.
Nucleic Acid Related Compounds. Part 125. Fluoro, Alkylsulfanyl, and Alkylsulfonyl Leaving Groups in Suzuki Cross‐Coupling Reactions of Purine 2′‐Deoxynucleosides and Nucleosides. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
In vitro supplementation with dAMP/dGMP leads to partial restoration of mtDNA levels in mitochondrial depletion syndromes (2009)

Mitochondrial DNA depletion syndrome, a frequent cause of childhood (hepato)encephalomyopathies, is defined as a reduction of mitochondrial DNA copy number related to nuclear DNA. It was previously shown that mtDNA depletion can be prevented by dAMP/dGMP supplementation in deoxyguanosine kinase-deficient fibroblasts. We investigated myotubes of patients diagnosed with mtDNA depletion carrying pathogenic mutations in DGUOK, POLG1 (Alpers syndrome) and TYMP. Differentiating myotubes of all patients and controls were supplemented with different doses of dAMP/dGMP or dAMP/dGMP/dCMP in TYMP deficiency, and analysed for mtDNA/nDNA ratio and for cytochrome c oxidase (COX) activity. Serum deprivation and myotube formation triggered a decrease in mtDNA copy number in DGUOK or POLG1 deficient myotubes, but not in TYMP deficiency and healthy controls. Supplementation with dAMP/dGMP leads to a significant and reproducible rescue of mtDNA depletion in DGUOK deficiency. POLG1 deficient myotubes also showed a mild, not significant increase in mtDNA copy number. MtDNA depletion did not result in deficient COX staining in DGUOK and POLG1-deficient myotubes. Treatment with ethidium bromide resulted in very severe depletion and absence of COX staining in all cell types, and no recovery was observed after supplementation with dAMP/dGMP. We show that supplementation with dAMP/dGMP increases mtDNA copy number significantly in DGUOK deficient myotubes and, leads to a mild, non-significant improvement of mtDNA depletion in POLG1 deficiency. No adverse effect on mtDNA copy number was observed on high-dose supplementation in vitro. Further studies are needed to determine possible therapeutic implications of dAMP/dGMP supplementation for DGUOK deficiency in vivo.
Skeleton based action recognition using translation-scale invariant image mapping and multi-scale deep CNN (2017)

We present an image classification based approach to large scale action recognition from 3D skeleton videos. Firstly, we map the 3D skeleton videos to color images, where the transformed action images are translation-scale invariance and dataset independent. Secondly, we propose a multi-scale deep convolutional neural network (CNN) for the image classification task, which could enhance the temporal frequency adjustment of our model. Even though the action images are very different from natural images, the fine-tune strategy still works well. Finally, we exploit various kinds of data augmentation methods to improve the generalization ability of the network. Experimental results on the largest and most challenging benchmark NTU RGB-D dataset show that our method achieves the state-of-the-art performance and outperforms other methods by a large margin.
Extremal quantum states and their Majorana constellations (2015)

The characterization of quantum polarization of light requires knowledge of all the moments of the Stokes variables, which are appropriately encoded in the multipole expansion of the density matrix. We look into the cumulative distribution of those multipoles and work out the corresponding extremal pure states. We find that SU(2) coherent states are maximal to any order whereas the converse case of minimal states (which can be seen as the most quantum ones) is investigated for a diverse range of the number of photons. Taking advantage of the Majorana representation, we recast the problem as that of distributing a number of points uniformly over the surface of the Poincar\'e sphere.
A PLSA-based language model for conversational telephone speech (2004)

This paper describes experiments with a PLSA-based language model for conversational telephone speech. This model uses a long-range history and exploits topic information in the test text to adjust probabilities of test words. The PLSA-based model was found to lower test set perplexity over a traditional word+class-based 4-gram by 13% (optimistic estimate using a reference transcript as history) or by 6% (realistic estimate using recognised transcript as history). Moreover, this paper introduces a use of confidence scores to weight words in the history, a weight of the prior topic distribution and a way of calculating perplexity that accounts for recognition errors in the model context.
Quantum Cryptography (1995)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. D. Franson, "Quantum Cryptography," Optics & Photonics News 6(3), 30-33 (1995) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article