gebhart/patrepeval huggingface dataset:
Study of data hiding mechanism using virtual key replacement method (2017)

Web is the quickest developing correspondence medium and fundamental piece of foundation, these days. To adapt to the development of web it has turned into a steady battle to keep the mystery of data and when benefits are included, secure the copyright of information. To give mystery and copyright of information a large number of the stegnograhic systems has been created. In any case, each of the procedure has their particular upsides and downsides. Where one strategy needs in keeping up the picture quality and furthermore constrained information concealing limit. Along these lines, the primary inspiration of proposed work is to defeat these weaknesses.
Mitochondrial RNase H1 activity regulates R-loop homeostasis to maintain genome integrity and enable early embryogenesis in Arabidopsis (2021)

Plant mitochondrial genomes undergo frequent homologous recombination (HR). Ectopic HR activity is inhibited by the HR surveillance pathway, but the underlying regulatory mechanism is unclear. Here, we show that the mitochondrial RNase H1 AtRNH1B impairs the formation of RNA:DNA hybrids (R-loops) and participates in the HR surveillance pathway in Arabidopsis thaliana. AtRNH1B suppresses ectopic HR at intermediate-sized repeats (IRs) and thus maintains mitochondrial DNA (mtDNA) replication. The RNase H1 AtRNH1C is restricted to the chloroplast; however, when cells lack AtRNH1B, transport of chloroplast AtRNH1C into the mitochondria secures HR surveillance, thus ensuring the integrity of the mitochondrial genome and allowing embryogenesis to proceed. HR surveillance is further regulated by the single-stranded DNA-binding protein ORGANELLAR SINGLE-STRANDED DNA BINDING PROTEIN1 (OSB1), which decreases the formation of R-loops. This study uncovers a facultative dual targeting mechanism between organelles and sheds light on the roles of RNase H1 in organellar genome maintenance and embryogenesis.
Network measurement of the VMTP request-response protocol in the V distributed system (1987)

Communication systems are undergoing a change in use from stream to request-response or transaction communication. In addition, communication systems are becoming increasingly based on high-speed, low delay, low error rate channels. These changes call for a new generation of networks, network interfaces, and transport protocol design. The performance characteristics of request-response protocols on these high-performance networks should guide the design of this new generation, yet relatively little data of this nature is available.
A Universally Unique IDentifier (UUID) URN Namespace (2005)

This specification defines a Uniform Resource Name namespace for UUIDs
(Universally Unique IDentifier), also known as GUIDs (Globally Unique
IDentifier). A UUID is 128 bits long, and can guarantee uniqueness
across space and time. UUIDs were originally used in the Apollo
Network Computing System and later in the Open Software
Foundation\'s (OSF) Distributed Computing Environment (DCE), and
then in Microsoft Windows platforms. This specification is derived
from the DCE specification with the kind permission of the OSF (now
known as The Open Group). Information from earlier versions of the DCE
specification have been incorporated into this document. [STANDARDS-
TRACK]
Risk Minimization Measures for Blood Screening HIV-1 Nucleic Acid Amplification Technique Assays in Germany (2013)

HIV differs from other blood-borne viruses with regard to its fast evolution of new viral variants. The evolution of new sequences is hardly predictable; therefore, NAT assays with only 1 target region appear to be more vulnerable to sequence variations than dual-target assays. The associated risk may be higher for HIV-1 NAT assays used for blood screening compared to quantitative assays used for monitoring HIV-1-infected patients. In HIV-1 screening NAT assays of dual-target design may adequately address the risk imposed by new HIV-1 variants.
Faculty Opinions recommendation of Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms. (2018)

Biocompatible polymers, such as polydimethylsiloxane (PDMS), are the materials of choice for creating organ-on-a-chip microfluidic platforms. Desirable qualities include ease of fabrication, optical clarity, and hydrophobicity, the latter of which facilitates oxygen transport to encased cells. An emerging and important application of organ-on-a-chip technology is drug discovery; however, a potential issue for polymer-based microfluidic devices has been highlighted by recent studies with PDMS, which have demonstrated absorption (and thus loss) of hydrophobic drugs into PDMS under certain experimental conditions. Absorption of drug in the polymer can also lead to undesirable transfer of drug between adjacent microfluidic lines. Given the benefits of polymers, it is essential to develop a comprehensive understanding of drug absorption. In this study, we considered convection, dissolution, and diffusion of a drug within a polymer-based microfluidic device to characterize the dynamics of drug loss in a quantitative manner. We solved Fick's 2nd law of diffusion (unsteady diffusion-convection) by finite element analysis in COMSOL®, and experimentally validated the numerical model for loss of three hydrophobic molecules (rhodamine B, cyanine NHS ester, and paclitaxel) in PDMS. Drug loss, as well as the unintended mixing of drugs by adjacent microfluidic channels, depends strongly on platform design parameters, experimental conditions, and the physico-chemical properties of the drug, and can be captured in a simple quantitate relationship that employs four scalable dimensionless numbers. This simple quantitative framework can be used in the design of a wide range of polymer-based microfluidic devices to minimize the impact of drug absorption. PMID: 28102869 Funding information This work was supported by: NCATS NIH HHS, United States Grant ID: UH3 TR000481 NCI NIH HHS, United States Grant ID: R01 CA170879
Constrained Peptides as Miniature Protein Structures (2012)

This paper discusses the recent developments of protein engineering using both covalent and noncovalent bonds to constrain peptides, forcing them into designed protein secondary structures. These constrained peptides subsequently can be used as peptidomimetics for biological functions such as regulations of protein-protein interactions.
Bimodal labeling of lipopolysaccharides (LPS) for SPECT-CT and fluorescence dual imaging (2012)

info:eu-repo/semantics/nonPublished
Stress exposure using small mobile robot both in immature and mature period induces mental disorder in rat (2012)

The number of patients with mental disorders is increasing in advanced countries, hence more effective psychotropic drugs are recently desired. In process of development of psychotropic drugs, animal experiments have been playing a very important role. Mental disorder model animals which exhibit behavior disorder like patients with mental disorders are used in these experiments. These animals are normally developed by genetic manipulation, surgical operation in their brain or drug administration. A candidate for a new drug is administrated in these animals to evaluate its effect. However, we have some doubts about conventional mental disorder model animals because they are induced these disorders by using methods which are quite different from causes of mental disorder of human beings. Therefore, the purpose of this study is to develop an novel methodology to create mental disorder model animals. We then developed a small mobile robot and a control system for it. Using them, we have performed some experiments to create a mental disorder model rat. We had then succeeded in developing a mental disorder model rat by exposing stress using the robot during immature period. This rat exhibits low activity in some behavior tests during mature period. For better understanding of how stress exposure induces mental disorder in a rat, we conducted another experiment based on stress vulnerability hypothesis. In this experiment, stress was exposed during both immature and mature period while that had been exposed only during immature period. We prepared several conditions of stress exposure by changing robot behavior pattern to find the one to induce much stress in a rat. From a result of experiment, we found that a rat which received gentle chase by the robot during immature period was induced much stress when it received robot attack during mature period. Thus, we consider that this rat is more appropriate to the mental disorder model than that was developed in our past experiment.
[Assessment of quality of life as an endpoint of cancer treatment]. (2000)

In order to evaluate the efficacy of cancer therapy, it is important to assess quality of life (QOL) as an endpoint in addition to tumor size reduction and survival. Thus, assessment of QOL has been included in many clinical trials of cancer therapy. These studies use various multiple QOL scales. We have translated the English version of the FACT-BL (Functional Assessment of Cancer Therapy for Bladder Cancer) questionnaire into Japanese. In the process, we performed a comparative study simultaneously using this questionnaire and EORTC QLQ-C30J which is generally used for various cancer patients. We found that FACT-BL provides a more sensitive assessment of the QOL of patients with advanced bladder cancer than EORTC QLQ-C30J. This means that we should carefully choose a questionnaire which is directly related to disease site, symptoms and treatment and can be conducted clinically. In the future, the assessment of QOL will have an important role as an endpoint of cancer treatment if the methodology and infrastructure, such as coordinators and data centers, are established in Japan.
Synthesis and biological evaluation of oleanolic acid derivative–chalcone conjugates as α-glucosidase inhibitors (2014)

Series of oleanolic acid derivative–chalcone conjugates were designed, synthesized and their α-glucosidase inhibitory activities were investigated<italic>in vitro</italic>.
Gut‐homing CD4+ T cell receptor αβ+ T cells in the pathogenesis of murine inflammatory bowel disease (1994)

We studied which T cell subsets from the gut-associated lymphoid tissue (GALT) can migrate out of the gut mucosa and repopulate GALT compartments of an immunodeficient (semi)syngeneic host. Many distinct lymphocyte subsets were found in GALT of immunocompetent H-2d (BALB/c, BALB/cdm2, C.B-17+/+) mice. No antigen receptor-expressing lymphoid cells were found in GALT of congenic C.B-17 scid/scid (scid) mice. The heterotopic transplantation of a full-thickness gut wall graft from the ileum or colon of immunocompetent (C.B-17+/+, BALB/cdm2) donor mice onto immunodeficient scid mice selectively reconstituted a CD3+ T cell receptor alpha beta+ CD4+ T cell subset. CD4+ cells of this subset expressed the surface phenotype of mucosa-seeking, memory T cells. In the immunodeficient scid host, this gut-derived CD4+ T cell subset was found in spleen, peritoneal cavity, mesenteric lymph nodes (LN), epithelial layer and lamina propria of the small and large intestine, but not in peripheral LN. Scid mice heterotopically transplanted with gut from a congenic, immunocompetent donor developed clinical and histological signs of inflammatory bowel disease (IBD). Hence, the selective repopulation of GALT compartments with CD4+ T cells from normal GALT plays an essential role in the pathogenesis of IBD in an immunodeficient host.
<title>Present performance of InGaN-based blue/green/yellow LEDs</title> (1997)

InGaN single-quantum-well (SQW) structure blue/green light- emitting diodes (LEDs) were fabricated. At 20 mA, the output power and the external quantum efficiency of the blue SQW LEDs were 5 mW and 9.1 percent, respectively. Those of the green SQW LEDs will a 10 degree cone viewing angle was 10 cd at 20 mA. A white LED made by combining a blue InGaN SQW LED and yttrium aluminium garnet phosphor, which is less expensive than a white LED composed of three primary color LEDs, was developed.
A Phase II Study of Ganetespib as Second-line or Third-line Therapy for Metastatic Pancreatic Cancer (2017)

Single-agent ganetespib was tolerable with only modest disease control in rMPC. This disease is resistant to chemotherapy, and given the emerging data in lung and rectal cancers, as well as in pancreatic cancer cell lines, suggesting improved activity of ganetespib in combination with cytotoxic agents, studies combining this agent with chemotherapy in rMPC are more likely to yield success.
Late-onset X-linked sideroblastic anemia following hemodialysis (2003)

Abstract X-linked sideroblastic anemia (XLSA) is due to deficient activity of erythroid-specific 5-aminolevulinate synthase (ALAS2). We report here a patient who developed sideroblastic anemia at the age of 81 years while undergoing hemodialysis. The diagnosis of sideroblastic anemia was established by the presence of ringed sideroblasts in the bone marrow, and treatment with oral pyridoxine completely eliminated the ringed sideroblasts. We identified a novel point mutation in the fifth exon of this patient's ALAS2 gene, which resulted in an amino acid change at residue 159 from aspartic acid to asparagine (Asp159Asn). In vitro analyses of recombinant Asp159Asn ALAS2 revealed that this mutation accounted for the pyridoxine-responsiveness of this disease. The very late onset in this case of XLSA emphasizes that nutritional deficiencies caused either by dietary irregularities in the elderly or, as in this case, by maintenance hemodialysis therapy, may uncover occult inherited enzymatic deficiencies in the heme biosynthetic pathway.
A novel process and hardware architecture to reduce burn-in cost (2006)

This paper presents a novel process and hardware architecture that dramatically reduces the cost of burn-in for performance CPUs. This also demonstrates that Moore's law can be sustained for BI in face of many challenges
Abstract: Scattering of Diatomic and Polyatomic Molecules from the (100) Crystal Face of Platinum (1973)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation L. A. West, G. A. Somorjai; Abstract: Scattering of Diatomic and Polyatomic Molecules from the (100) Crystal Face of Platinum. Journal of Vacuum Science and Technology 1 January 1973; 10 (1): 273. https://doi.org/10.1116/1.1317976 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science and Technology Search Advanced Search |Citation Search
Solvation Model Based on Order Parameters and a Fast Sampling Method for the Calculation of the Solvation Free Energies of Peptides (2006)

An analytical solvation model is proposed as a function of an order parameter, which represents the local arrangement of water molecules in the first solvation shell of peptide atoms. The model is combined with a fast sampling method, rotational isomeric state Monte Carlo, to sample efficiently the torsional degrees of freedom on a peptide backbone. This order parameter solvation model is shown to reproduce without ad hoc fitting parameters the solvation free energies of single amino acids and tripeptides with slightly better accuracy than the generalized Born model but with several orders of magnitude improvement in efficiency. This method is a potential candidate for efficiently and accurately tackling some important issues in biophysical chemistry that are related to solvation, for example, protein folding, ligand binding, etc. Our results also present fundamental new insights into solvation. Specifically, the local water geometry, represented in this work by a properly defined order parameter, carries the majority, if not all, of the energetic information of solvation, including solute-solvent interactions and solvent reorganization in the presence of the solute.
Reciprocal transmissions and asymmetric modal distributions in waveguide-coupled spiral-shaped microdisk resonators (2007)

We report transmission spectra and mode-field distributions of a waveguide-coupled spiral-shaped microdisk resonator on a silicon nitride-on-silica substrate. Our measured and simulated transmission spectra reveal reciprocal transmissions between clockwise and counterclockwise travelingwaves of such microcavity that lacks mirror symmetry. Our measured out-of-plane scattering intensity distributions and simulated steady-state mode-field patterns, however, indicate asymmetric modal distributions that depend on the sense of lightwave circulations and the input-coupling mechanisms. We discuss implications of the observed reciprocal transmissions with asymmetric modal distributions to unidirectional lasing from spiral-shaped microcavities reported in the literature.
Twenty-Seventh Fungal Genetics Conference, Asilomar, CA, March 12-17, 2013 (2013)

This meeting brings together ~900 international scientists to discuss the latest research on fungal genetics. Sessions of particular relevance to DOE include lignocellulose degradation, cellulose conversion to fermentable sugars, fermentation of sugars to fuel molecules. Other sessions cover fungal diseases of biomass crops (miscanthus, corn, switchgrass, etc.).
Theory of resonant acoustic transmission through subwavelength apertures (2008)

The discovery of the phenomenon of extraordinary optical transmission through a two-dimensional array of subwavelength holes in a metallic film has opened a new line of research within optics. The key role played by surface plasmons in transferring light efficiently from the input side of the metal film to the output region was soon realized. This fundamental knowledge enabled extension of this surface-plasmon ability to achieve extraordinary optical transmission and strong collimation of light in a single hole surrounded by a finite periodic array of indentations. Here, we show how these ideas developed for electromagnetic radiation can be transferred to other classical waves such as acoustic waves.
Physical mechanisms of short-pulse laser ablation (1999)

Removal of material from the surface of metals and semiconductors following irradiation with pico- or femtosecond laser pulses is a thermal process involving states of matter having unusually thermodynamic, hydrodynamic and optical properties.
Papers Presented during 68th Annual Assemly of International Institute of Welding Held at Helsinki, Finland on June - July 2015:Welding as A Career-Indian Perspective (2015)

In today's highly competitive world every individual is keen on acquiring or continues to acquire such qualifications, certifications that will help him progress in his career, preferably, at a rapid phase. The term progress most of the time means higher emoluments, benefits, positions in the organisation etc. In order to achieve this, individuals keep looking at the industry trends, emerging opportunities, feedback from their friends etc. and take decisions as to how they should equip themselves to progress further in their career. Some individual don't hesitate to make even drastic changes in their field of activities to embrace new opportunities. In such a scenario where does welding stand? Does it offer a good career? Is it worth venturing in this field? What sort of personnel is required in this field? Is it an equally sought after field and if not why not? Is it a developing field or a field waiting to be written off? Is it a recent field or an ancient field of technology which has not developed over the ages? What type of job can it provide and what will be the type of environment in which we may be working? Does it provide opportunities for all engineering fields or only to a few? Is there any formal qualification, certification leading to specific jobs of it is a field full of self-formulated personnel? Where one can get details of the opportunities in this field? This paper tries to answer most of these questions and also discusses as to why welding can be an equally good career opportunity for many individuals. Welding is an important and critical activity in many industries. Many surveys project a very good demand for qualified, certified welding personnel at various levels. This field so far has not been a favourite, preferred field for many especially the younger generation though it is on par with many other fields in terms of opportunities, emoluments etc. This is mainly because of the lack of complete information about the opportunities in this field and many misconceptions. The concerted efforts being made by several agencies should go a long way in removing these and it is hoped that the variety of training, education and certification programs presently in place for welding personnel at various levels should be able to generate sufficient number of welding personnel to meet the huge demands of the industries in India and abroad.
On the Degrees of Freedom of the MISO Interference Broadcast Channel\n with Delayed CSIT (2019)

The Maddah-Ali and Tse (MAT) scheme is a linear precoding strategy that\nexploits Interference Alignment and perfect, but delayed, channel state\ninformation at the transmitters (delayed CSIT), improving the degrees of\nfreedom (DoF) that can be achieved for the broadcast channel (BC). Since its\nappearance, many works have extended the concept of Retrospective Interference\nAlignment (RIA) to other multi-user channel configurations. However, little is\nknown about the broadcast channel with multiple cells, i.e. the interference\nbroadcast channel (IBC). In this work, the DoF are studied for the $K$-user\n$C$-cell multiple-input single-output (MISO) IBC with delayed CSIT (with $K/C$\nusers per cell).\n We show that the straightforward application of the MAT scheme over the IBC\nfails because it requires all interference to be received from the same source.\nHence, in this case not all the interference can be cancelled, thus blocking\nthe decoding of the received messages. We call this phenomenon as\n\\textit{interference coupling}, forcing to use the MAT scheme by serving just\none cell at a time. In this work, we propose an extension, namely the uncoupled\nMAT scheme (uMAT), exploiting multiple cells, uncoupling the interference, and\nachieving the best known DoF inner bound for almost all settings.\n
Tests of Fermilab built 40 mm aperture full length SSC dipole magnets (1992)

Several 40-mm-aperture, 17-m-long dipoles have been built by Fermilab as developmental prototypes for the Superconducting Super Collider (SSC). These magnets have an external inner-outer coil splice design, a collet style end clamp assembly, a new, analytically designed minimum stress coil end design, and a new insulation system which does not employ shims or 'shoes'. In addition, the magnets were built using production-style tooling. The magnets were tested at the Fermilab Magnet Testing Facility. Quench testing and mechanical measurement results are presented and analyzed with emphasis on the new design and fabrication features of these magnets. The performance of these magnets was very good from a quench and mechanical behavior standpoint. The magnets did not exhibit excessive training behavior and only one training quench was below the nominal operating current. The coil prestress remained positive to >7 T in both magnets and most of the quenches originated in the high field region of the pole turn.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>