gebhart/patrepeval huggingface dataset:
Bond fixation in annulenes. 5. Absolute configuration and chiroptical properties of optically active 1,2,3-trimethyl- and 1,2,3,4-tetramethylcyclooctatetraenes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBond fixation in annulenes. 5. Absolute configuration and chiroptical properties of optically active 1,2,3-trimethyl- and 1,2,3,4-tetramethylcyclooctatetraenesJohn M. Gardlik, Larry K. Johnson, Leo A. Paquette, Barbara A. Solheim, James P. Springer, and Jon ClardyCite this: J. Am. Chem. Soc. 1979, 101, 6, 1615–1617Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://pubs.acs.org/doi/10.1021/ja00500a053https://doi.org/10.1021/ja00500a053research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Mineral Carbonation for Carbon Utilization in Microalgae Culture (2019)

This paper presents a study on the combination of mineral carbonation with biomass production. Laboratory experiments were performed to investigate the growth of freshwater green microalgae Scenedesmus obliquus in the presence of dissolving mineral carbonates, such as nahcolite (NaHCO3) and nesquehonite (MgCO3·3H2O) at atmospheric conditions and 25 °C. The cell density of the algae biomass was determined using fluorescence measurements. A biochemical model was implemented to describe the evolution of the biomass and the consumption of carbon substrate. The parameter estimates show that the algae growth kinetics in the presence of either NaHCO3 or MgCO3·3H2O is similar and is comparable to the literature. Moreover, when MgCO3·3H2O is supplied, the algae appear to form clusters, which favor their separation from the solution. Overall, this work analyzes the potential to combine two carbon dioxide (CO2) utilization options, i.e., mineral carbonation and microalgae cultivation, and it demonstrates the feasibility of the process. However, control of the pH and the carbon dosage is required to attain optimal biomass productivity.
Surface texture and barrier performance of poly(lactic acid)–cellulose nanocrystal extruded‐cast films (2019)

ABSTRACT In this study, we assessed the influence of cellulose nanocrystal (CNC) addition level (0.5–2 wt %) on the surface texture, thickness, and barrier properties of poly(lactic acid) (PLA) extruded‐cast films. Regardless of the CNC content, the addition of CNC increased the surface average roughness and maximum roughness of the PLA films in both the machine and cross‐machine directions because of the presence of CNC agglomerates. The increased roughness resulted in films with uneven thicknesses; this affected their accurate measurements with a conventional micrometer. Rather, accurate thickness measurements were obtained through the density method, a more appropriate thickness measurement method for films with rough surfaces. The permeability values were negatively correlated with the increased crystallinity. Both the water vapor permeability and oxygen permeability (OP) values decreased significantly by approximately 26–45 and 25–50%, respectively, as the CNC content increased from 0.5 to 2 wt % because of the tortuosity effect. The OP values of the neat PLA and composite films remained insensitive to changes in the relative humidity (from 0 to 75%) when they were tested at 23 °C. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47594.
An approach to behavioral synthesis for loop-based BIST (2003)

This paper presents an approach to behavioral synthesis for loop-based BIST. By taking into account the requirements of the BIST scheme during behavioral synthesis processes, an area optimal BIST solution can be obtained. This approach is based on the use of rest resources reusability which results in a fewer number of registers being modified as BIST registers. This is achieved by incorporating testability constraints during register assignment operations. Experimental results on benchmarks are presented to demonstrate the effectiveness of the approach.
Serological biomarkers for acute mesenteric ischemia (2019)

Acute mesenteric ischemia (AMI) defines a complex of conditions characterized by an interruption of the splanchnic circulation, leading to insufficient oxygen delivery or utilization to fill the metabolic needs of the visceral organs. Early diagnosis and immediate therapy are the cornerstones of early ischemia to reach a successful outcome and are necessary to reduce the high mortality. Although there is still lack of specific biomarkers to assist the diagnosis of AMI in clinical practice, there are several biomarkers with high specificity, may become a potential tools in early diagnosis of AMI, including intestinal fatty acid binding protein (I-FABP), a-glutathione S-transferase (a-GST), D-dimer, L- and D-lactate, citrulline, ischemia modified albumin, procalcitonin (PCT). However, they use in clinical limited duo to the many studies about these makers finished with small patient populations, and heterogeneous among these populations. This review describes the etiology of AMI, the current most studied promising biomarkers, the current research situation and future of biomarker research.
Construction schedule optimization for high arch dams based on real-time interactive simulation (2015)

The construction process of high arch dams is extremely complicated. Therefore, optimization of the construction schedule is essential for construction management to save a large amount of time and investment costs. Construction simulation is an important tool for the construction schedule optimization of high arch dams. Most current studies involving construction schedule simulations do not concurrently consider real-time construction situations and site managers' requirements. In this paper, the real-time interactive simulation is proposed that could solve this problem. The real-time construction process is the initial condition of the simulation, and the actual construction parameters are the basis of the simulation parameters. Additionally, site managers can change the simulation strategy dynamically or enter requirements based on real-time construction situations. For a simulation result, different schemes are optimized with the entropy weight method. With this method, the construction simulation can track the rapid changes in construction situations and provide a reasonable construction schedule, which increases the flexibility of the construction simulation. The optimized construction scheme could be an effective guide for site construction. With a 4D (three dimensional model and time) CAD model, the simulation process can be well expressed. A case study shows that the construction schedule can be established in real time, and it's a useful tool for decision-making.
The self-assembly of a highly ordered [2]catenane (1991)

Template-directed synthesis has been used to construct a [2]catenane in which the two molecular components, the cyclobis(paraquat-p-phenylene) tetracation and 1,5-dinaphtho-38-crown-10, are found to be ordered non-covalently with respect to each other in both the solid (by X-ray crystallography) and solution (by NMR spectroscopy) states and to influence each other to the extent of establishing electrochemical gradients for the stepwise one electron reductions of the two paraquat units.
Prognosis and Management after a First Myocardial Infarction (1990)

PATIENTS who have a first myocardial infarction deserve consideration as a special group. For the most part, the early mortality rate from a first infarction is roughly half the rate found in patients with a second or third infarction,1 , 2 and the long-term survival is considerably better than in patients who have had previous infarctions.3 , 4 The published studies on risk stratification4 5 6 and treatment7 8 9 after an infarction have paid remarkably little attention to patients having their first myocardial infarction. Such patients constitute a majority (60 to 80 percent) of those with acute infarction, yet they are rarely viewed as a special group. . . .
Preliminary investigation of cytotoxic potential of 2-quinolone derivatives using in vitro and in vivo (solid tumor and liquid tumor) models of cancer (2012)

2-Quinolone analogs are powerful inhibitors of farnesyl transferase, and are a novel class of anticancer drugs. The present study focused on continual efforts to elucidate the anticancer activity of synthesized 2-quinolone derivatives without N-methyl or 3-aryl substitution. Three derivatives namely JST, JST2 and JST13 were synthesized in our lab and screened for in vitro and in vivo anticancer activities. Significant cytotoxicity was observed in MCF-7 cells treated with JST2 and JST13. Both the derivatives’ treatment showed damage to the DNA. In vivo studies for JST2 and JST13 were performed at two doses 100 and 200 mg/kg using Ehrlich ascites carcinoma (liquid) and Dalton lymphoma ascites (solid) models. Both derivatives showed a significant reduction in the tumor progression by increasing the mean life span and by improving the haematological profile and antioxidant status of the liver in a liquid tumor model. More prominent effect was observed in a solid tumor model by reduction in solid tumor weight and tumor volume.
Association of the BANK1 R61H variant with systemic lupus erythematosus in Americans of European and African ancestry (2008)

Abstract: Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs10516487, within the B-cell gene BANK1 and systemic lupus erythematosus (SLE) as a consequence of a genome wide association study of this disease in European and Argentinean populations. In a bid for replication, we examined the effects of the R61H non-synonymous variant with respect to SLE in our genotyped American cohorts of European and African ancestry. Utilizing data from our ongoing genome-wide association study in our cohort of 178 Caucasian SLE cases and 1808 Caucasian population-based controls plus 148 African American (AA) SLE cases and 1894 AA population-based controls we inves-tigated the association of the previously described non-synonymous SNP at the BANK1 locus with the disease in the two ethnicities separately. Using a Fisher’s exact test, the minor allele frequency (MAF) of rs10516487 in the Caucasian cases was 22.6 % while it was 31.2 % in
Deuterium Kinetic Isotope Effect Studies of a Potential in Vivo Metabolic Trapping Agent for Monoamine Oxidase B (2018)

Visualizing the in vivo activity of monoamine oxidase B (MAO-B) is a valuable tool in the ongoing investigation of astrogliosis in neurodegeneration. Existing strategies for imaging changes in MAO enzyme expression or activity have utilized the irreversible suicide inhibitors or high-affinity reversibly binding inhibitors as positron emission tomography (PET) ligands. As an alternative approach, we developed 4-methyl-7-[(1-[<sup>11</sup>C]methyl-1,2,3,6-tetrahydropyridin-4-yl)oxy]-2 H-chromen-2-one ([<sup>11</sup>C]Cou) as a metabolic trapping agent for MAO-B. Trapping of [<sup>11</sup>C]Cou in rhesus monkey brain demonstrated MAO-B selectivity. In this work, we have attempted to improve on the in vivo pharmacokinetics of [<sup>11</sup>C]Cou by using the deuterium kinetic isotope effect (KIE) to slow the MAO-B-mediated oxidation step and thus reduce the rate of trapping in brain tissues. However, in vitro assays of enzyme kinetics and in vivo PET imaging of pharmacokinetics in primate brain showed no effects of deuterium substitution on the tetrahydropyridine ring of [<sup>11</sup>C]Cou. The results are possibly due to masking of the KIE by a second step in the overall metabolism of the new imaging agent.
Predicting the Degree of Distracted Driving Based on fNIRS Functional Connectivity: A Pilot Study (2022)

Abstract Distracted driving is one of the main causes of traffic accidents. By predicting the attentional state of drivers, it is possible to prevent distractions and promote safe driving. In this study, we developed a model that could predict the degree of distracted driving based on brain activity. Changes in oxyhemoglobin concentrations were measured in drivers while driving a real car using functional near-infrared spectroscopy (fNIRS). A regression model was constructed for each participant using functional connectivity as an explanatory variable and break reaction time to random beeps while driving as an objective variable. As a result, we were able to construct a prediction model for 11 of the 12 participants. Furthermore, the regression model with the highest prediction accuracy for each participant was analyzed to gain a better understanding of the neural basis of distracted driving. The 11 models were classified into five clusters by hierarchical clustering based on their functional connectivity edges used in each cluster. The results showed that the combinations of the dorsal attention network (DAN)-sensory motor network (SMN) and DAN-ventral attention network (VAN) connections were common in all clusters and that these networks were essential to predict the degree of distraction in complex multitask driving. They also confirmed the existence of multiple types of prediction models with different within- and between-network connectivity patterns. These results indicate that it is possible to predict the degree of distracted driving based on the brain activity of the driver during actual driving. These results are expected to contribute to the development of safe driving systems and elucidation of the neural basis of distracted driving.
Biochemical properties of tartrate-resistant acid phosphatase in serum of adults and children. (1978)

Spectrophotometry of total acid phosphatase activity in children's sera showed an average value of 22.4 +/- 2.9 and 7.4 +/- 0.8 U/liter, for the hydrolysis of p-nitrophenyl phosphate and alpha-naphthyl phosphate, respectively. Analyses of "band 5b", after electrophoresis on acrylamide gel, gave even higher values. The values for children's sera were much higher than those for sera from adults. The multiplicity of acid phosphatases in sera of children and adults was studied by electrophoresis on acrylamide gel and by chromatography on CM-Sepharose. Both methods showed the major acid phosphatase in children's sera to be an acid pyrophosphatase, band 5b. Its catalytic properties are indistinguishable from the enzyme previously isolated from the spleen of leukemic reticuloendotheliosis.
Association of the heart fatty acid‐binding protein (FABP3) gene with milk traits in Manchega breed sheep (2004)

The ovine fatty acid-binding protein type 3 gene has been chosen as a functional candidate gene for milk traits. Two different single nucleotide polymorphisms (SNPs) of ovine FABP3 gene have been tested in a daughter design comprising 13 families. No association was found between estimated breeding values for milk yield, protein and fat contents (FC) and genotypes across families using anova and transmission disequilibrium test (TDT). In within-family analysis, one family showed a significant effect for FC. These results could indicate linkage disequilibrium between the FABP3 gene and a quantitative trait loci (QTL) for FC, with the heterozygous genotype associated with a positive effect in this trait.
Sensitivity of MRI parameters within intervertebral discs to the severity of adolescent idiopathic scoliosis (2016)

We successfully performed an in vivo multiparametric MRI investigation of young patients with adolescent idiopathic scoliosis. The MRI parameters measured within the intervertebral discs were found to be sensitive to intervertebral disc degeneration occurring with scoliosis and to the severity of scoliosis. J. Magn. Reson. Imaging 2016;44:1123-1131.
Relationship between Abdominal Fat Distribution Assessed by Computed Tomography and Serum Lipids in the Elderly. (1993)

A nutritional assessment is necessary to evaluate the pathophysiological state of patients, and serum lipids are one of the factors which must be evaluated. Body fat distribution is considered to be associated with cardiac diseases, metabolic diseases and hypertension. In this study, we performed quantitative measurements of fat distribution by X-ray computed tomography (CT) in 31 elderly outpatients. Thirteen males (mean age 74.8 years) and 18 females (mean age 75.4 years) were examined by abdominal CT. All subjects had body mass indices within the normal range and did not have malignant disease, hyperlipidemia, liver dysfunction or diabetes mellitus. CT scans were carried out at the level of the middle abdomen; these scan slices included intraabdominal fat which consisted of omental, retroperitoneal and perirenal adipose tissues. Subcutaneous fat areas and intraabdominal fat areas were measured from six 10-mm-thick slice films using a 2-dimensional computerized calculator. The relationship between serum lipids and fat distribution was also examined. The ratio of intraabdominal adipose tissue area to subcutaneous adipose tissue area (V/S) was higher in males than in females. V/S correlated positively with serum triacylglycerol and correlated negatively with serum HDL-Ch. These results suggest that the measurement of body fat distribution is important to evaluate lipid metabolism and nutritional states in the elderly.
ADAR1 RNA Deaminase Limits Short Interfering RNA Efficacy in Mammalian Cells (2004)

Double-stranded RNA induces the homology-dependent degradation of cognate mRNA in the cytoplasm via RNA interference (RNAi) but also is a target for adenosine-to-inosine (A-to-I) RNA editing by adenosine deaminases acting on RNA (ADARs). An interaction between the RNAi and the RNA editing pathways in Caenorhabditis elegans has been suggested recently, but the precise mode of interaction remains to be established. In addition, it is unclear whether this interaction is possible in mammalian cells with their somewhat different RNAi pathways. Here we show that ADAR1 and ADAR2, but not ADAR3, avidly bind short interfering RNA (siRNA) without RNA editing. In particular, the cytoplasmic full-length isoform of ADAR1 has the highest affinity among known ADARs, with a subnanomolar dissociation constant. Gene silencing by siRNA is significantly more effective in mouse fibroblasts homozygous for an ADAR1 null mutation than in wild-type cells. In addition, suppression of RNAi effects are detected in fibroblast cells overexpressing functional ADAR1 but not when overexpressing mutant ADAR1 lacking double-stranded RNA-binding domains. These results identify ADAR1 as a cellular factor that limits the efficacy of siRNA in mammalian cells.
Microsoft SQL Server 2000 administrator's companion (2000)

This title is the definitive daily operations guide to planning, deploying, and maintaining Microsoft SQL Server 2000. With it, administrators learn how to use this scalable, high-performance relational database management system to solve complex business challenges, launch Internet-based solutions, and lower the cost and complexity of distributed database solutions. This comprehensive reference introduces new features of both SQL Server 2000 and the Microsoft Windows 2000 operating system. And it includes an expanded section covering installation and setup, an example-rich segment on how to use SQL Server 2000 to create and modify databases, and information about built-in features such as DTC, MTS, and OLAP services. It's the essential daily operations guide for the SQL Server database administrator!
ChemInform Abstract: Generation and Cycloadditions of Hydroxy(and Trimethylsiloxy)phenylethynyl Ketene. (1988)

Abstract 3,6‐Dimethoxy‐o‐benzoquinone (I) reacts with phenylethynyllithium (II) to form the dialkynylcyclohexadienediol (III) which rearranges upon treatment with ZnCl 2 to give the bicyclooctadienone (IVa).
Actively crosslinked microtubule networks: mechanics, dynamics and filament sliding (2018)

Cytoskeletal networks are foundational examples of active matter and central to self-organized structures in the cell. In vivo, these networks are active and heavily crosslinked. Relating their large-scale dynamics to properties of their constituents remains an unsolved problem. Here we study an in vitro system made from microtubules and XCTK2 kinesin motors, which forms an aligned and active gel. Using photobleaching we demonstrate that the gel's aligned microtubules, driven by motors, continually slide past each other at a speed independent of the local polarity. This phenomenon is also observed, and remains unexplained, in spindles. We derive a general framework for coarse graining microtubule gels crosslinked by molecular motors from microscopic considerations. Using the microtubule-microtubule coupling, and force-velocity relationship for kinesin, this theory naturally explains the experimental results: motors generate an active strain-rate in regions of changing polarity, which allows microtubules of opposite polarities to slide past each other without stressing the material.
ASSESSING THE FORAGING BEHAVIOR OF AGRIOTES SORDIDUS WIREWORMS IN DUAL-CHOICE OLFACTOMETERS. (2014)

The different steps of the foraging process of wireworms (Coleoptera: Elateridae) would be better understood if accurate and holistic information regarding the role of plant-produced chemicals constituting their environment were available. Volatile organic compounds (VOC) play important roles in the interactions between plants and insects in many ecosystems, whether they take place aboveground or below-ground. The roles of VOC are still relatively unknown for wireworms, and deserve attention. Here, we performed three experimentations with barley roots as baits. In the two first, we assessed the effect of chopped roots and fungus infected roots on the orientation of wireworms. In the third experiment, the larvae were confronted to both healthy and fungus infected roots. We discuss the results in terms of suitability of the olfactometers we designed for the investigation of olfaction in wireworms, and we provide suggestions to improve their use.