gebhart/patrepeval huggingface dataset:
Repair of Isoaspartate Formation Modulates the Interaction of Deamidated 4E-BP2 with mTORC1 in Brain (2010)

In eukaryotes, a rate-limiting step of translation initiation is recognition of the mRNA 5' m(7)GpppN cap structure by the eukaryotic initiation factor 4F (eIF4F), a heterotrimeric complex consisting of the cap-binding protein, eIF4E, along with eIF4G, and eIF4A. The eIF4E-binding proteins (4E-BPs) repress translation by disrupting eIF4F formation, thereby preventing ribosome recruitment to the mRNA. Of the three 4E-BPs, 4E-BP2 is the predominant paralog expressed in the mammalian brain and plays an important role in synaptic plasticity and learning and memory. 4E-BP2 undergoes asparagine deamidation, solely in the brain, during early postnatal development. Deamidation spontaneously converts asparagines into a mixture of aspartates or isoaspartates, the latter of which may be destabilizing to proteins. The enzyme protein L-isoaspartyl methyltransferase (PIMT) prevents isoaspartate accumulation by catalyzing the conversion of isoaspartates to aspartates. PIMT exhibits high activity in the brain, relative to other tissues. We report here that 4E-BP2 is a substrate for PIMT. In vitro deamidated 4E-BP2 accrues isoapartyl residues and is methylated by recombinant PIMT. Using an antibody that recognizes 4E-BP2, which harbors isoaspartates at the deamidation sites, Asn(99) and Asn(102), we demonstrate that 4E-BP2 in PIMT-/- brain lysates contains isoaspartate residues. Further, we show that 4E-BP2 containing isoaspartates lacks the augmented association with raptor that is a feature of deamidated 4E-BP2.
Wavelength reconfigurable photonic switching using thermally tuned micro-ring resonators fabricated on silicon substrate (2007)

Micro-ring resonators have been traditionally fabricated using expensive III-V materials such as InP or GaAs. Device tuning is typically to utilize the electro-optic effect of the III-V materials that usually leads to complex device layer structures. As another tuning approach, thermo-optic tuning of micro-ring resonators is commonly achieved by heating up the whole chip. In general, it is more challenging to achieve highly localized heating on a common chip for independent tuning of multiple micro-ring resonators residing on the same substrate. To address these issues, we describe the development of wavelength reconfigurable photonic switching using thermally tuned micro-ring resonators fabricated on a low-cost silicon-on-insulator substrate. Independent tuning of multiple micro-ring resonators, spaced at 250 µm, is realized with highly localized micro heaters (50&times;50 &mu;m<sup>2</sup> per heater area) fabricated on the same silicon substrate. Owing to the large thermo-optic effect of silicon (&Delta;n/&Delta;T=1.8&times;10<sup>-4</sup> K<sup>-1</sup>), 8 mA heating current is sufficient to tune a micro-ring resonator with a 3-dB spectral line width of 0.1 nm by 2.5 nm while creating a minor peak shift of less than 0.04 nm for an adjacent resonator. The switching response time is about 1 ms. A 1&times;4 wavelength reconfigurable photonic switch device has been demonstrated. With a resonator diameter of approximately 10 &mu;m (greater than 18 nm in free spectral range of each micro-ring resonator), larger port-count switch matrix with wavelength reconfiguration on a small device foot print is feasible for the development of large-scale integrated photonics.
Social Media As A Source Of Unbiased News (2014)

News media are usually biased toward some political views. Also, the coverage of news is limited to news reported by news agencies. Social media is currently a hub for users to report and discuss news. This includes news reported or missed by news media. Developing a system that can generate news reports from social media can give a global unbiased view on what is hot in a given region. In this talk, we present the research work performed in QCRI for two years, which tackle the problem of using social media to track and follow posts on ongoing news in different regions and for different topics. Initially, we show examples of the presence of bias in reporting news by different news media. We then explore the nature of social media platforms and list the research questions that motivated this work. The challenges for tracking topics related to news are discussed. An automatically adapting information filtering approach is presented that allows tracking broad and dynamic topics in social media. This technique enables automatically tracking posts on news in social media while coping with the high changes occurring in news stories. Our developed system, TweetMogaz, is the demoed, which is an Arabic news portal platform that generated news from Twitter. TweetMogaz reports in real-time what is happening in hot regions in the Middle East, such as Syria and Egypt, in the form of comprehensive reports that include top tweets, images, videos, and news article shared by users on Twitter. It also reports news on different topics such as sports. Moreover, Search is enabled to allow users to get news reports on any topic of interest. The demo would be showing www.tweetmogaz.com live, where emerging topics in news would appear live in front of the audience. By the end of the talk, we would show some of the interesting examples that were noticed on the website in the past year. In addition, a quick overview would be presented on one of the social studies, which was carried out based on the news trend changes on TweetMogaz. The study shows the changes of people behavior when reporting and discussing news during major political changes such as the one happened in Egypt in July 2013. This work is an outcome of two years of research in the Arabic Language Technology group in Qatar Computing Research Institute. The work is published in the form of six research and demo papers in tier 1 conferences such as SIGIR, CSCW, CIKM, and ICWSM. The TweetMogaz system is protected by two patent applications filed in 2012 and 2014. Currently the website serves around 10,000 users, and the number is expected to significantly increase when officially advertised. Please feel free to visit TweetMogaz website for checking the system live: www.tweetmogaz.com Note: A new release with a better design to the website is expected by the time of the conference
The Sustainability of Health and Safety on Construction Sites in Zamfara State (2018)

Construction industry has been attributed to be the growth of Nigerian economic and infrastructural development. Annual reports show that consistent accidents on construction sites in Zamfara State has affected substantial number of workers as they become temporarily or permanently disabled, thereby making many construction sites a death trap. It is as a result of high construction site accident currently experiencing in Zamfara state that this research was carried out to appraise the sustainability of health and safety of construction workers on sites. Subsequently, SPSS Version 20 was used to analyse descriptive statistical analysis. Furthermore, the findings highlighted that the performance and output of construction workers on construction sites depends on proper practice of health and safety. The research findings also recommended ways to enhance employers and employee’s compliance to existing laws guiding health and safety on Zamfara State construction sites.
Hydrogen Peroxide Can Enhance the Synthesis of Bioactive Compounds in Harvested Broccoli Florets (2022)

Hydrogen peroxide (H 2 O 2 ) is a reactive oxygen species (ROS) which participates in the signal transduction responses of plants toward biotic and abiotic stresses. Therefore, the objective of this study was to link the exposure of low doses of H 2 O 2 to the improvement of the phytochemical composition of broccoli florets, in particular the content of glucosinolates (GLS), and hydroxy-cinnamates (HCA) without affecting the quality parameters of the vegetable. A dose of 1.25 mM H 2 O 2 applied for 180 min was effective (hormetic) in maintaining the color of broccoli florets, which was also compared with a higher dose of 5.0 mM H 2 O 2 applied for 180 min. The intensity of the treatments was related to respiration rate, which was monitored for 21 d at 4◦C along to weight loss. The initial respiration rate of florets exposed to both doses of H 2 O 2 was significantly ( p &amp;lt; 0.0001) higher relative to controls and resulted in weight loss in florets treated with the hormetic dose. The antioxidant capacity of florets, measured indirectly as Oxygen Radical Absorbance Capacity (ORAC) and ascorbic acid (AA), decreased in florets exposed to both doses. The concentration of glucobrassicins, aliphatic GLS, and HCA was consistently higher in florets treated with the two doses, compared to non-exposed florets. The enhancement of these compounds was accompanied by the over expression, immediately (6 h) after treatments, of tryptophan N-hydroxylase 2 (CYP79B3), dihomomethionine N-hydroxylase (CYP79F1), and phenylalanine ammonia-lyase (PAL) genes. Overall, the tested doses of H 2 O 2 positively influenced the augmentation of indole-type and aliphatic GLS, as well as HCA in broccoli florets.
Spatial and temporal patterns of Leptospira infection in dogs from northern California: 67 cases (2001–2010) (2013)

The use of geographic information systems provided a visual representation of the results of statistical analysis for the location and time at which leptospirosis cases occurred. This useful tool can be used to educate veterinary practitioners and the public about a potentially fatal zoonotic disease and direct vaccination strategies to help prevent disease occurrence.
Electric Field Calculation Based on PIDC in Monocomponent Development Systems (2002)

Conventionally, electric fields in a development nip are often calculated for well-defined patterns (solid areas and isolated lines) or for a given charge distribution on the photoconductor surface. We propose an alternative method for field calculation based on various physical parameters of the development system. It uses a set of laser and photoconductor parameters to compute the exposure energy on the photoconductor surface, and the corresponding photoconductor surface potential is obtained from the Photo-Induced Discharge Characteristics (PIDC) of the photoconductor. The surface potential is then used as a boundary condition for solving Poisson's equation. The normal and horizontal fields are subsequently obtained by taking the negative gradient of the voltage. This method accounts for what is commonly known as dot-overlapping. Thus, electric fields anywhere in the gap for an arbitrary input bitmap can be calculated. Using our field model, simulation results from various input patterns are presented.
Early Declines in Vaccine Type Pneumococcal Carriage in Children Less Than 5 Years Old After Introduction of 10-valent Pneumococcal Conjugate Vaccine in Mozambique (2018)

Declines in VT carriage were observed in both HIV-uninfected and HIV-infected children after PCV10 introduction with an early signal of herd effect especially in HIV-infected children. Ongoing monitoring of increases in 19A carriage and disease is necessary.
“[Cp*CoCoCp*]” is a Hydride (1992)

The supposed synthesis of the cobalt complex [Cp * CoCoCp * ] was in the spotlight at the end of last year ( Angew. Chem. Int. Ed. Engl. 1991, 30 , 1124). But the compound described at that time is actually the mixed‐valent cobalt hydride 2 . The reaction of the dinuclear complex 1 with LiAlH 4 yields two paramagnetic cobalt complexes ( 2 and 3 ), which have been fully characterized by X‐ray crystallography and spectroscopic methods, as well as by protonation and carbonylation. See also the Corrigendum on p. 1392. equation image
Unsupervised optimal fuzzy clustering (1989)

This study reports on a method for carrying out fuzzy classification without a priori assumptions on the number of clusters in the data set. Assessment of cluster validity is based on performance measures using hypervolume and density criteria. An algorithm is derived from a combination of the fuzzy K-means algorithm and fuzzy maximum-likelihood estimation. The unsupervised fuzzy partition-optimal number of classes algorithm performs well in situations of large variability of cluster shapes, densities, and number of data points in each cluster. The algorithm was tested on different classes of simulated data, and on a real data set derived from sleep EEG signal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
End-to-End Network Topology Generation (2007)

Motivated by the desire to generate topologies which take into account the dynamic failure and growth of the Internet nodes and links, we identify the need for high quality, multi-scale, end-to-end network topology generators. After examining a number of commonly used generators and comparing their output with data sources available at wide area (AS level), ISP (IP routing level) and enterprise networks, we are developing a mechanism for synthetically generating topologies which are able to represent networks across multiple scales. We are extending this work to include the dynamic evolution of networks.
Demonstrating Parallel Adaptation: How Switching between Two Virtual Bodies with Different Perspectives Enables Dual Motor Adaptation (2022)

We demonstrate a dual-motor adaptation over 2 virtual bodies with opposite visuomotor rotation (+ 15° and − 15°). A related study explored the effect of view perspective (1st person view perspective, 1pp, and 3rd person view perspective, 3pp) on a dual motor adaptation behavior. They showed that (1) in 1pp, the adaptation is explicit, while in 3pp, the adaptation is implicit, and (2) the implicit adaptation led to a better dual adaptation. Here we let the participants experiment with explicit and implicit dual motor adaptation by doing a reaching task in 1pp and then in 3pp. We present an ad-hoc motor adaptation score and discuss which adaptation behavior led to a better dual adaptation.
A study of target heating in low-energy ion-beam processing (1986)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S. A. Ringel, X. C. Mu, S. J. Fonash, S. Ashok; A study of target heating in low‐energy ion‐beam processing. J. Vac. Sci. Technol. A 1 September 1986; 4 (5): 2385–2388. https://doi.org/10.1116/1.574082 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Recent advances in hydrophilic modification of PVDF ultrafiltration membranes – a review: part II (2017)

This two-part review article – the first instalment of which was published in last month's issue of the newsletter, whilst the second appears here – focuses on recent advances in hydrophilic modification methods that are applied to poly(vinylidene fluoride) (PVDF) ultrafiltration (UF) membranes (UFMs) in order to enhance antifouling performance, mechanical strength and chemical resistance.
Thermodynamics and Kinetics of Graphene Growth on SiC(0001) (2009)

The formation of surface phases on the Si-terminated SiC(0001) surface, from the Si-rich (3x3) structure, through the intermediate (1x1) and (sqrt[3]xsqrt[3])-R30 degrees structures, to the C-rich (6sqrt[3]x6sqrt[3]) phase, and finally epitaxial graphene, has been well documented. But the thermodynamics and kinetics of these phase formations are poorly understood. Using in situ low energy electron microscopy, we show how the phase transformation temperatures can be shifted over several hundred degrees Celsius, and the phase transformation time scales reduced by several orders of magnitude, by balancing the rate of Si evaporation with an external flux of Si. Detailed insight in the thermodynamics allows us to dramatically improve the morphology of the final C-rich surface phases, including epitaxial graphene.
Whole-Genome Sequences of Staphylococcus aureus ST398 Strains of Animal Origin (2013)

Staphylococcus aureus sequence type 398 (ST398) was originally associated with animal infections. We announce the complete genome sequences of two ST398 methicillin-susceptible S. aureus strains from the livestock environment. These genome sequences assist in the characterization of interesting ST398 features relying on host tropism and epidemiological settings.
Fabrication of compact wavelength add/drop filter circuits using a cross grid array vertically coupled to microring resonators (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. T. Chu, B. E. Little, W. Pan, T. Kaneko, and Y. Kokubun, "Fabrication of compact wavelength add/drop filter circuits using a cross grid array vertically coupled to microring resonators," in Integrated Photonics Research, OSA Technical Digest Series (Optica Publishing Group, 1999), paper RMB3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Unified low-order modeling approach to can-annular combustors (2023)

We present a unified, physics-based low-order modeling approach to can-annular combustors, combining a linear stability analysis and a nonlinear Langevin approach to unravel the highly complex, multi-physical dynamics in this type of system. In the linear part, Howe's Rayleigh conductivity model is combined with the projected Helmholtz equation and a Bloch wave ansatz to arrive at a single equation for the frequency spectrum of an N-can combustor. Starting from first principles, we illustrate and give a physical explanation for the coupling-induced amplification and suppression of thermoacoustic instabilities. Adding another layer of complexity, we then take into account nonlinearities in the flame response and the aeroacoustic coupling. The nonlinear dynamics of a symmetric model combustor are explored by exploiting the gradient structure of the averaged slow-flow dynamics. We obtain exact analytical expressions for the steady-state statistics, highlighting the connection between different emergent patterns and the resistive coupling between the cans. We leverage our analysis to explain the intermittent energy transfer between Bloch modes observed in real-world gas turbines.
Outside the horizontal blinds effects on indoor light environment (2013)

The simulation room size is: 6 m × 4 m × 3 m, the window facing south, with size 2 m × 1.8 m, in which the width of the window frame is 0.15 m. Room model is shown in Figure 1. Figure 1(a) for the model with no shutter, Figure 1(b) as the model with blinds.
Prevention of Post-Operative Pain after Elective Brain Surgery: A Meta-Analysis of Randomized Controlled Trials (2023)

<i>Background and Objective:</i> To analyze the effects of several drug for pain prevention in adults undergoing craniotomy for elective brain surgery. <i>Material and Methods:</i> A systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The inclusion criteria were limited to randomized controlled trials (RCTs) that evaluated the effectiveness of pharmacological treatments for preventing post-operative pain in adults (aged 18 years or older) undergoing craniotomies. The main outcome measures were represented by the mean differences in validated pain intensity scales administered at 6 h, 12 h, 24 h and 48 h post-operatively. The pooled estimates were calculated using random forest models. The risk of bias was evaluated using the RoB2 revised tool, and the certainty of evidence was assessed according to the GRADE guidelines. <i>Results:</i> In total, 3359 records were identified through databases and registers' searching. After study selection, 29 studies and 2376 patients were included in the meta-analysis. The overall risk of bias was low in 78.5% of the studies included. The pooled estimates of the following drug classes were provided: NSAIDs, acetaminophen, local anesthetics and steroids for scalp infiltration and scalp block, gabapentinoids and agonists of adrenal receptors. <i>Conclusions:</i> High-certainty evidence suggests that NSAIDs and acetaminophen may have a moderate effect on reducing post-craniotomy pain 24 h after surgery compared to control and that ropivacaine scalp block may have a bigger impact on reducing post-craniotomy pain 6 h after surgery compared to control. Moderate-certainty evidence indicates that NSAIDs may have a more remarkable effect on reducing post-craniotomy pain 12 h after surgery compared to control. No moderate-to-high-certainty evidence indicates effective treatments for post-craniotomy pain prevention 48 h after surgery.
Introduction to the Virtual Issue Honoring Robert Bergman’s 2017 Wolf Prize in Chemistry (2017)

ADVERTISEMENT RETURN TO ISSUEEditor's PageNEXTIntroduction to the Virtual Issue Honoring Robert Bergman's 2017 Wolf Prize in ChemistryPaul J. ChirikView Author Information Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United StatesCite this: Organometallics 2017, 36, 5, 957–959Publication Date (Web):March 13, 2017Publication History Published online13 March 2017Published inissue 13 March 2017https://pubs.acs.org/doi/10.1021/acs.organomet.7b00134https://doi.org/10.1021/acs.organomet.7b00134editorialACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views968Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (187 KB) Get e-AlertscloseSUBJECTS:Catalysis,Functionalization,Organometallic chemistry,Transition metals Get e-Alerts
Influence of the Acidification Process on the Colloidal Stability of Acidic Milk Drinks Prepared from Reconstituted Nonfat Dry Milk (1995)

Studies on the stabilization of acidic milk drinks with pectin require the availability of well-defined preparations of acidic milk drink, but traditional acidic milk drinks suffer from problems of reproducibility because of variations of milk quality and bacterial fermentation.The possibility of replacing bacterial fermentation of fresh milk by chemical acidification with glucono-A-lactone of reconstituted nonfat dry milk has been considered.The addition of 3% g1ucono-Alactone and subsequent incubation at
A Backprojection Algorithm for Electrical Impedance Imaging (1990)

The authors study a two-dimensional reconstruction algorithm due to D. C. Barber and B. H. Brown, applied to a linearized electrostatic inverse problem. First, the authors demonstrate how this algorithm fits within the framework of inverses of generalized Radon transforms studied by G. Beylkin. Second, an iterative improvement of the Barber–Brown algorithm is constructed based on the conjugate residual method. Several numerical results obtained with this iterative algorithm are presented.