gebhart/patrepeval huggingface dataset:
[Primary leiomyoma of the lung, with clear-cell features and admixed alveolar spaces: description of a case presenting with pneumothorax]. (2003)

The patient, a 18-year-old female, non smoker, presented with a well-delimited pleuro-pulmonary mass, 6,5 cm across, located in the right upper lobe. The mass was discovered 5 years previously, following an episode of spontaneous pneumothorax; initially interpreted as an intralobar pulmonary sequestration, it was subsequently removed due to a small dimensional increase. A gynaecological examination, a thoracic CT-scan obtained 2 years after operation, and a recent abdomino-pelvic echography were negative. The patient is alive and well 7 years after surgery. Microscopically, the lesion was well delimited and it was punctuated by multiple cysts of variable dimensions, covered by bland cubic cells. The solid part of the lesion was composed by oval, clear cells, merging with fusiform elements with densely eosinophilic cytoplasm. Significant atypia, mitoses and necrosis were absent. Immunohistochemically, both oval and spindle cells were strongly positive for vimentin, smooth muscle actin, desmin and h-caldesmon, negative for cytokeratin, EMA, CD-34, CD-10, CD-117, HMB-45, TTF-1, BCL-2, GFAP, calretinin, chromogranin, estrogen and progesterone receptors. Cells covering the cystic spaces were positive for cytokeratin, TTF-1 and EMA, negative for all the other antibodies tested. Smooth muscle proliferations of the lung are briefly discussed, together with the most important problems in differential diagnosis.
Microresonators as promising building blocks for VLSI photonics (2005)

In the last years much effort has been taken to arrive at optical integrated circuits with high complexity and advanced functionality. For this aim high index contrast structures are employed that allow for a large number of functional elements within a given chip area: VLSI photonics. It is shown that optical microresonators can be considered as promising basic building blocks for filtering, amplification, modulation, switching and sensing. Active functions can be obtained by monolithic integration or a hybrid approach using materials with thermo-, electro- and opto-optic properties and materials with optical gain. Examples are mainly taken from work at MESA<sup>+</sup>.
Context-Dependent Sentiment Analysis in User-Generated Videos (2017)

Soujanya Poria, Erik Cambria, Devamanyu Hazarika, Navonil Majumder, Amir Zadeh, Louis-Philippe Morency. Proceedings of the 55th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2017.
EMS Providers and Exception from Informed Consent Research: Benefits, Ethics, and Community Consultation (2012)

The EMS providers in our study valued research and were willing to participate in studies. Support for research was balanced with concerns and challenges regarding the role of providers in the research process.
A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes (1997)

To examine the structural basis for the specific recognition of the MHC class I allotypes HLA-Cw*0401 and HLA-Cw*0304 by the killer cell inhibitory receptors (KIR) cl42 and cl43, respectively, mutant KIR-Ig fusion proteins were tested by direct binding to cells transfected with single HLA-C alleles. The putative loop region at position 44-46 of KIR contained amino acids that were necessary for the discrimination between HLA-Cw*0401 and HLA-Cw*0304. Surprisingly, exchanging the methionine at position 44 in cl42 with the lysine at position 44 in cl43 was sufficient to switch the specificity of cl42 from HLA-Cw*0401 to HLA-Cw*0304, and vice versa. Thus, a single amino acid in the first Ig domain of these KIR determines their ability to discriminate between the two groups of HLA-C allotypes.
Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large‐cell lymphoma and inflammatory myofibroblastic tumor (2002)

ALK-positive anaplastic large-cell lymphoma (ALCL) has been recognized as a distinct type of lymphoma in the heterogeneous group of T/Null-ALCL. While most of the ALK-positive ALCL (ALKomas) are characterized by the presence of the NPM-ALK fusion protein, the product of the t(2;5)(p23;q35), 10-20% of ALKomas contain variant ALK fusions, including ATIC-ALK, TFG-ALK, CLTC-ALK (previously designated CLTCL-ALK), TMP3-ALK, and MSN-ALK. TMP3-ALK and TMP4-ALK fusions also have been detected in inflammatory myofibroblastic tumors (IMTs), making clear that aberrations of the ALK gene are not associated exclusively with the pathogenesis of ALK-positive ALCL. Here we report results of molecular studies on two lymphoma cases and one IMT case with variant rearrangements of ALK. Our study led to the detection of the CLTC-ALK fusion in an ALCL case and to the identification of two novel fusion partners of ALK: ALO17 (KIAA1618), a gene with unknown function, which was fused to ALK in an ALCL case with a t(2;17)(p23;q25), and CARS, encoding the cysteinyl-tRNA synthetase, which was fused to ALK in an IMT case with a t(2;11;2)(p23;p15;q31). These results confirm the recurrent involvement of ALK in IMT and further demonstrate the diversity of ALK fusion partners, with the ability to homodimerize as a common characteristic.
Convergence theory for fuzzy c-means: Counterexamples and repairs (1987)

A counterexample to the original incorrect convergence theorem for the fuzzy <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</i> -means (FCM) clustering algorithms (see J.C. Bezdak, IEEE Trans. Pattern Anal. and Math. Intell., vol.PAMI-2, no.1, pp.1-8, 1980) is provided. This counterexample establishes the existence of saddle points of the FCM objective function at locations other than the geometric centroid of fuzzy <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</i> -partition space. Counterexamples previously discussed by W.T. Tucker (1987) are summarized. The correct theorem is stated without proof: every FCM iterate sequence converges, at least along a subsequence, to either a local minimum or saddle point of the FCM objective function. Although Tucker's counterexamples and the corrected theory appear elsewhere, they are restated as a caution not to further propagate the original incorrect convergence statement.
Preparation of regularly Sequenced polyamides, containing definite numbers of oxyethylene units (1981)

Abstract Polyamides 3 containing constant and definite numbers of oxyethylene units were prepared by condensation polymerization of suitable diamines and diesters, both of which containing oxyethylene units. The polymer structure was determined by IR and 1 H NMR spectroscopy. Almost all polymers are crystals melting at ≈ 40°C and show a complexation ability towards alkalimetal cations. It was also found that diesters containing oxyethylene units show a higher condensation rate than alkylene diesters, which is explained by an inductive effect of the ether oxygene. However, no remarkable difference in the condensation rate was found between diamines containing oxyethylene units and the corresponding aliphatic diamines.
Histone Deacetylase 11 (HDAC11) as a Novel Molecular Target in Mantle Cell Lymphoma (2008)

Abstract Mantle Cell Lymphoma (MCL) is a B-cell Non-Hodgkin’s Lymphoma characterized by the translocation t(11;14)(q13;32) and a consequent Cyclin D1 over-expression. The clinical evolution of MCL is very aggressive, and currently there is no standard of care for this malignancy. In spite of the known association of Histone Deacetylases (HDACs) and solid malignancy growth, little is known regarding the role of these enzymes in MCL. We recently found newest member of the HDAC family, HDAC11, a molecule with an unknown prior physiological role, is a strong transcriptional repressor of gene expression1. Interestingly, we have found a significant over-expression of HDAC11 in murine as well as in human MCL cell lines. In primary cells from patients with MCL, we observed that higher levels of HDAC11 are associated with a more aggressive disease, while low expressions of HDAC11 are seen in patients with the indolent variant of MCL. Microarray analysis of cells in which HDAC11 expression was silenced revealed significant down regulation of specific genes involved in the control of apoptosis, cell cycle, methylation and B-cell survival. Critical genes regulated by HDAC11 include IL-10 and IL-6, cytokines known to be survival factors for malignant B-cells. In addition, we have unveiled a previously unknown association between HDAC11, cyclin D1, and Cyclin Dependent Kinase Inhibitors (CDKI), molecules that play a central role in the pathogenesis of MCL.
Skeletal Complications of Gaucher Disease (1985)

Gaucher disease is a collection of related disorders of sphingolipid catabolism caused by the deficiency of a specific beta-glucosidase. The inefficiency of this enzyme, glucocerebrosidase, to degrade its natural substrate leads to the accumulation of the complex lipid glucocerebroside in tissue macrophages. The pathogenesis of the disease is, as yet, poorly understood. The manifestations of the disease are protean with hepatosplenomegaly and bone deterioration frequently the predominating signs. The disease most frequently causes disability because of its effects on the skeleton. This review seeks to summarize the current clinical understanding of these complications. Experience with 327 patients reveals that the bone disease in this disorder is extremely variable. The severity of the problems range from asymptomatic persons with neither radiographic, scintigraphic, nor histologic evidence of bone involvement to those whose skeleton is completely devastated by a process of osteopenia, osteonecrosis, and osteosclerosis. These severely affected individuals show the most bizarre deformities in their bones and are subject to pathologic fracture. Most patients fortunately, are less profoundly affected, but many are plagued by bone pain of an arthritic nature or by an acute prostrating bone crisis probably best described as a bone infarction. The accepted etiology that these crises are a result of vascular compromise produced by occlusion of vessels by Gaucher cells is not supported by scintigraphic or histologic studies. Moreover, the vascular hypothesis does not explain the variety of lesions of the skeleton seen in this multifocal bone disease. Preliminary metabolic and endocrinologic studies suggest that this is not a systemic disorder of metabolism which affects bone uniformly. On the contrary, the lesions are multiple and localized, and sometimes much of the skeleton is preserved. These observations suggest that bone is affected because of collections of Gaucher cells scattered throughout its substance and may be the result of a toxic process around these foci. Alternatively, the storage of glucocerebroside in tissue macrophages may disturb the generation of competent osteoclasts and thus result in a failure to maintain a healthy skeleton. Further research is needed to delineate the pathogenesis of this disorder before any effective therapy can be developed.
Specific amino acid patterns define split specificities of HLA-B15 antigens enabling conversion from DNA-based typing to serological equivalents (2020)

The HLA-B15 typing by serological approaches defined the serological subgroups (or splits) B62, B63, B75, B76, B77 and B70 (B71 and B72). The scarcity of sera with specific anti-HLA antibodies makes the serological typing method difficult to discriminate a high variety of HLA antigens, especially between the B15 antigen subgroups. Advancements in DNA-based technologies have led to a switch from serological typing to high-resolution DNA typing methods. DNA sequencing techniques assign B15 specificity to all alleles in the HLA-B*15 allele group, without distinction of the serological split equivalents. However, the presence of antibodies in the patient defined as split B15 antigens urges the identification of HLA-B*15 allele subtypes of the donor, since the presence of donor-specific antibodies is an important contraindication for organ transplantation. Although the HLA dictionary comprises information regarding the serological subtypes of HLA alleles, there are currently 394 B15 antigens out of 516 in the IPD-IMGT/HLA database (3.38.0) without any assigned serological subtype. In this regard, we aimed to identify specific amino acid patterns for each B*15 serological split, in order to facilitate the assignment of B*15 alleles to serological equivalents after high-resolution molecular typing. As a result, serological specificities of 372/394 not yet assigned alleles could be predicted based on amino acid motifs. Furthermore, two new serological types were identified and added, B62-Bw4 and B71-Bw4.
Design Optimization Module For Hierarchical Research And Learning Environment (2020)

The present paper describes a learning module on design optimization courses within a hierarchical research and learning network (HRLN). In this environment a knowledge organization can be created as a hierarchical learning network to link diverse inter-and transdisciplinary teams from a consortium of universities, industry, government agencies and the providers of learning technologies. It is an approach that builds on computer-based training, intelligent tutoring systems, interactive learning, collaborative-distributed learning, and learning networks. The present design optimization module has been developed and described herein, as a demonstrator of a learning module in this environment. This module allows for the learners of design optimization to get the course material at their own convenience and time either via the internet or packaged files. Consequently, it is expected that the learner's ability to understand design optimization and review its pertinent details will be enhanced significantly.
Use of micro-focused ultrasound with visualization to lift and tighten lax knee skin (2014)

Similar to its safety and efficacy for tightening facial skin and reducing wrinkles, MFU-V is an effective, noninvasive method for reducing skin laxity and improving the appearance of skin above the knee. ClinicalTrials.gov Identifier: NCT01708434.
Question-based computational language assessment shows higher validity than rating scales in the categorization of emotional state narratives (2022)

Abstract Psychological constructs are commonly quantified with closed-ended rating scales, however, recent advances in natural language processing (NLP) have been shown to allow for the quantification of open-ended language responses with unprecedented accuracy. Here, we showed that emotional events analysed by NLP show higher accuracy in categorizing emotional states than rating scales. One group of participants (N = 297) was asked to generate narratives related to four emotions – depression, anxiety, satisfaction, or harmony and to rate them on four standardized rating scales (i.e., PHQ-9, GAD-7, SWLS, and HILS). The second group of participants (N = 400 controls and N = 34 healthcare professionals), read the narratives produced by the first group, summarized them in five descriptive keywords, and rated the narratives on the same four emotional states. The descriptive words were quantified by NLP methods, and machine learning was used to categorize the responses into the corresponding emotional categories. The results showed a substantially more accurate categorization of the narratives based on descriptive words (64 %) than on rating scales (44 %), indicating that semantic measures have significantly higher predictive accuracy than the corresponding four rating scales. In conclusion, our results show that semantic responses can have a higher validity in categorizing narratives of emotions than validated Likert scales.
The triangular barrier switch (1982)

We set out to understand the operation of the triangular barrier switch. The device uses a regenerative feedback mechanism to attain abrupt switching. The switching characteristics suggest the presence of "safe" hole traps in the device. The effect of these traps upon the current conduction is taken into account in a simplified but illustrative analysis which we will carry out and predict the threshold switching current density. Comparison between the experimental data and the analysis shows a reasonably good agreement. This device can be easily integrated with the triangular barrier photodiode to form a light level switch.
Annexin A6 Is Critical to Maintain Glucose Homeostasis and Survival During Liver Regeneration in Mice (2020)

We conclude that the lack of AnxA6 compromises alanine-dependent GNG and liver regeneration in mice.
Çalışanların örgütsel güven algılarının işten ayrılma niyeti ve örgütsel özdeşleşme üzerine etkisi: Trabzon kereste ve mobilya işletmeleri örneği (2021)

Bu çalışmada, örgütsel güven alt boyutlarının işten ayrılma niyeti ve örgütsel özdeşleşme üzerine etkisinin belirlenmesi amaçlanmıştır. Aynı zamanda, kereste ve mobilya alanlarında faaliyet gösteren işletmelerde çalışan kişilerin örgütsel güven algıları ile işten ayrılma niyeti ve örgütsel özdeşleşme düzeyleri arasındaki ilişki tespit edilmeye çalışılmıştır. Çalışma evrenini Trabzon’daki ağaç ve ağaç ürünleri ve mobilya işletmelerinde çalışan kişiler (1507 kişi) oluşturmaktadır. Çalışma kapsamında 315 çalışana yüz-yüze yöntem ile anket uygulanmıştır ve 305 anket analizde kullanılmıştır. Çalışma sonucunda, örgütsel özdeşleşmenin en yüksek puan ortalamasına sahip olduğu bulunmuşken, işten ayrılma niyetinin en düşük puan ortalamasına sahip olduğu bulunmuştur. Çalışanlar en fazla iş arkadaşlarına ve en az örgüte güvendiklerini söylemiştir. Örgütsel güven boyutu ve alt boyutları ile işten ayrılma niyeti arasında anlamlı ve negatif ve örgütsel güven boyutu ve alt boyutları ile örgütsel özdeşleşme arasında anlamlı ve pozitif bir ilişki bulunmuştur. Son olarak, yöneticiye güven boyutunun işten ayrılma niyetini negatif yönde etkilediği belirlenirken, iş arkadaşlarına güven ve örgüte güven boyutlarının ise örgütsel özdeşleşmeyi pozitif yönde etkilediği belirlenmiştir.
The Affinity of the Dynein Microtubule-binding Domain Is Modulated by the Conformation of Its Coiled-coil Stalk (2005)

The microtubule-binding domain (MTBD) of dynein is separated from the AAA (ATPase with any other activity) core of the motor by an approximately 15-nm stalk that is predicted to consist of an antiparallel coiled coil. However, the structure of this coiled coil and the mechanism it uses to mediate communication between the MTBD and ATP-binding core are unknown. Here, we sought to identify the optimal alignment between the hydrophobic heptad repeats in the two strands of the stalk coiled coil. To do this, we fused the MTBD of mouse cytoplasmic dynein, together with 12-36 residues of its stalk, onto a stable coiled-coil base provided by Thermus thermophilus seryl-tRNA synthetase and tested these chimeric constructs for microtubule binding in vitro. The results identified one alignment that yielded a protein displaying high affinity for microtubules (2.2 microM). The effects of mutations applied to the MTBD of this construct paralleled those previously reported (Koonce, M. P., and Tikhonenko, I. (2000) Mol. Biol. Cell 11, 523-529) for an intact dynein motor unit in the absence of ATP, suggesting that it resembles the tight binding state of native intact dynein. All other alignments showed at least 10-fold lower affinity for microtubules with the exception of one, which had an intermediate affinity. Based on these results and on amino acid sequence analysis, we hypothesize that dynein utilizes small amounts of sliding displacement between the two strands of its coiled-coil stalk as a means of communication between the AAA core of the motor and the MTBD during the mechanochemical cycle.
Synthesis and Biological Evaluation of Coumarin Carboxamides as Selective andPotent Inhibitors of Carbonic Anhydrases IX and XII (2022)

These compounds may be utilized as useful starting points for the design and development of selective and potent hCA IX and XII inhibitors.
Demonstration of airway closure in man (1975)

After partial equilibration of the lung with a N2O gas mixture absorption of N2O by the pulmonary circulation results in a flow of gas into the lungs during breath holding. A bolus of 133Xe introduced at the mouth at the beginning of the breath hold is carried in by the gas flow and distributed according to regional perfusion. In three subjects, breath holding at FRC, apex-to-base distribution of a 133Xe bolud delivered by N2O absorption (Xecar) was similar to that of a bolus injected intravenously (Xeiv). Near RV however, much less of Xecar penetrated into dependent zones than expected from the distribution of Xeiv. In fact, distribution of Xecar did not differ from that of a slowly inhaled bolus. Correction for Compton scatter in the chest wall, measured in one subject, accounted only in part for the radioactivity recorded over dependent lung regions. The findings indicate that near RV some but not all of the dependent airways must be closed. Furthermore, the distribution of airway closure completely accounts for the distribution of a bolus inhaled from RV.
Dry film photo resists and polymers - the low cost option for standard and 3-D wafer level packaging (2010)

Driving packaging cost down is essential to make products cheaper. There are several options to reduce costs: One is to switch from one packaging technology to another (cheaper) one. The other is to cut costs for an existing process step by using cheaper material and/or a more cost effective process flow. For 3-D-packages dry films can be used as a photo mask for Si dry etching. They do have the capability to bridge over etched cavities or to create 3-D structure. Opportunities provided by the use of dry films will be discussed in the paper.
Gene Therapy for Ischemic Stroke (1998)

Cerebral ischemia occurs with deprivation of blood flow, caused either by vessel occlusion (focal ischemia) or cardiac arrest (global ischemia). Multiple pathophysiological changes accompanying ischemia lead first to a decrease of protein synthesis and functional impairment (transmission failure), and later to morphological damage (energy and membrane failure); they include depletion of energy reserves with anaerobic glycolysis and lactacidosis; release of excitatory amino acids (EAAs) leading to disturbance of ionic homeostasis (Ca2+, Na+) (1); free radical attack on lipids, proteins, and DNA; and up- and downregulation of specific gene programs (2). Despite recent advances in clinical neuropharmacology and pathophysiology, new therapeutic strategies are urgently needed, because stroke constitutes the third most common cause of death in North America.
A freshman level course on information assurance (2012)

research-article A freshman level course on information assurance: can it be done? here's how Share on Authors: Robin Gandhi University of Nebraska at Omaha, Omaha, Nebraska University of Nebraska at Omaha, Omaha, NebraskaView Profile , Connie Jones University of Nebraska at Omaha, Omaha, Nebraska University of Nebraska at Omaha, Omaha, NebraskaView Profile , William Mahoney University of Nebraska at Omaha, Omaha, Nebraska University of Nebraska at Omaha, Omaha, NebraskaView Profile Authors Info & Claims ACM InroadsVolume 3Issue 3September 2012 pp 50–61https://doi.org/10.1145/2339055.2339072Online:01 September 2012Publication History 2citation708DownloadsMetricsTotal Citations2Total Downloads708Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access