gebhart/patrepeval huggingface dataset:
Magnetotunneling measurement of space-charge accumulation inδ-doped quantum wells (1989)

Resonant tunneling wells with approximately V-shaped profiles have been fabricated by \ensuremath{\delta}-doping ${\mathrm{Al}}_{\mathrm{x}}$${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$As tunnel barriers. The structures show strong resonances in their current-voltage characteristics in qualitative agreement with the expected subband structure. Magnetotunneling experiments are shown to measure the electron density in the lowest subband which displays a strong asymmetry as a function of the bias voltage. This is indicative of an extremely asymmetric electric field distribution within the structure and is explained by a consideration of the dynamics of the electrons tunneling into, or out of, a slightly asymmetric well. The implications for asymmetries in other semiconductor structures are pointed out.
Comparison of Whole Blood and Peripheral Blood Mononuclear Cell Gene Expression for Evaluation of the Perioperative Inflammatory Response in Patients with Advanced Heart Failure (2014)

GEP analysis of WB has the potential to become a clinical tool for immune-monitoring in patients with MOD.
Escherichia coliSequence Type ST131 as the Major Cause of Serious Multidrug‐ResistantE. coliInfections in the United States (2010)

A single E. coli clonal group, ST131, probably caused the most significantly antimicrobial-resistant E. coli infections in the United States in 2007, thereby constituting an important new public health threat. Enhanced virulence and/or antimicrobial resistance compared with other E. coli, plus ongoing dissemination among locales, may underlie ST131's success. Urgent investigation of the sources and transmission pathways of ST131 is needed to inform mitigation efforts.
Nitrogen fixation and CO/sub 2/ metabolism: proceedings (1985)

Photosynthesis and nitrogen fixation are key metabolic processes which lead to the production of reduced carbon and nitrogen compounds. These compounds are essential for the maintenance and continuation of life on earth. In this volume many recent advances in the study of nitrogen fixation and photosynthetic carbon dioxide fixation are presented. The papers were presented in seven sessions. These sessions were the biochemistry of the legume nodule, genetics and molecular biology of nitrogen fixation, enzymes and cofactors involved in inorganic nitrogen reductions, aspects of nitrogen fixation by associations and symbioses, physiology of free-living nitrogen fixers, interactions between carbon metabolism and nitrogen fixation, photorespiration in plants, and photosynthetic carbon fixation. (DT)
Determining the Requirements for Gαi:β‐arrestin Complex Formation at G Protein‐Coupled Receptors (2022)

G protein‐coupled receptors (GPCRs) comprise the largest class of transmembrane receptors and are targeted by nearly a third of prescription drugs. Canonical GPCR signaling involves pathways mediated by G proteins and β‐arrestins (βarrs). While these have historically been thought of as separate, our lab has demonstrated that the inhibitory G protein Gα subunit (Gαi) and βarr form complexes following receptor activation. We have also shown that Gαi:βarr complex formation occurs even if the receptor signals through other classes of G proteins or lacks G protein activity altogether, as in the case of endogenously βarr‐biased Atypical Chemokine Receptor 3 (ACKR3). To expand on this work, we used a split nano‐luciferase assay to examine Gαi:βarr complex formation at βarr‐biased mutants of two ‘balanced’ receptors, which exhibit both G protein and βarr signaling— the type 1 Angiotensin II Receptor (AT1R) and D2 dopamine Receptor (D2R). Consistent with our results with ACKR3, we found that mutation of these other receptors to abrogate G protein‐mediated signaling did not eliminate Gαi:βarr association. Observing this at multiple additional receptors further supported the idea that G protein activity is not required for Gαi:βarr complex formation. To add to our characterization of the determinants of Gαi:βarr association, we then sought to explore how different mechanisms of βarr activation may contribute to complex formation at ACKR3. To accomplish this, we utilized previously described polar core, proximal finger loop, and lipid mutant βarr constructs. The polar core and proximal finger loop mutants achieve constitutive activation by different mechanisms, while the lipid mutant’s ability to be recruited to and bind at the plasma membrane is deficient; these result in decreased Gαi:βarr association at Vasopressin Receptor 2 (V2R). We compared these mutants’ ability to associate with Gαi at ACKR3. Our constitutively active βarr constructs showed differential abilities to form Gαi:βarr complexes compared to wild‐type βarr, suggesting that certain methods of βarr activation may be more relevant in Gαi:βarr complex formation than others. Additional insights into the determinants of Gαi:βarr association in the context of receptor, G protein, and βarr activity will enhance our understanding of the Gαi:βarr complex and its importance in GPCR signaling, potentially informing future development of therapeutic agents targeting GPCRs.
Improvements in computational accuracy of BRYNTRN (a baryon transport code) (1991)

Extension of BRYNTRN for use in space radiation dose analyses for very large shield thickness is made possible by improving the numerical algorithms. The efforts were concentrated in obtaining more accurate yet efficient interpolation and integration methods at each local computational step and in optimizing the grid distributions. A brief discussion of the nucleon transport theory and propagating formula is also given in conjunction with the analysis of error propagation which reveals the need for minimizing the local truncation errors. Sample calculations were made to verify the new algorithms. An accuracy of approximately 5 percent for a shield thickness of 150 g/sq cm was found when a minimal, thirty-point energy grid was used. This is far superior to the results obtained by using the old algorithms where the solutions can be of an order of magnitude different when a reasonable large number of grid points was used. The propagation step size which is restricted by the perturbation theory was re-evaluated to be in line with the improved numerical accuracy.
CNS active O-linked glycopeptides (2015)

Naturally occurring glycopeptides and glycoproteins play important roles in biological processes. Glycosylation is one of the most common post-translational modifications in vivo. Glycopeptides are involved in cell signaling and sorting, providing cell surface markers for recognition. From the drug design and synthesis perspective, modification of a peptide through glycosylation results in increased bioavailability and bioactivity of glycopeptides in living systems with negligible toxicity of degradation products. Glycopeptide synthesis can be accomplished through incorporation of a glycosylated amino acid in solid phase peptide synthesis (SPPS) to form the desired peptide, or via incorporation of sugar-amino acid moieties. Additionally, research indicates that glycosylation increases penetration of the blood-brain barrier (BBB) by peptides, which may lead to novel therapeutics for neurological disorders. Recent applications of glycopeptides have focused on the in vivo central nervous system (CNS) effects after peripheral administration of centrally active peptides modified with various carbohydrates.
Robust feedforward. tracking control based on sudden disturbance observer and ZPET control for optical disk recording system (2004)

This paper proposes a new robust tracking servo system for optical disk recording system with feedforward controller and sudden disturbance observer. In optical recording systems, the tracking servo system must suppress the influence of sudden disturbance and periodic disturbance. In order to suppress the periodic disturbance, this paper designs the feedforward control system with prediction of tracking error. For suppressing the sudden disturbance, this paper proposes the sudden disturbance observer by using the predictively tracking error. The experimental results point out that the proposed tracking servo system has a precise tracking response against both periodic disturbance and sudden disturbance.
In Vivo Efficacy Study Showing Comparative Advantage of Bacterial Infection Prevention with Zip-type Skin Closure Device vs. Subcuticular Sutures (2018)

There remains a lack of understanding of how wound closure methods perform comparatively when exposed to patient-induced movement during healing and how they may contribute to bacterial infiltration in the wound site. The present study attempts to objectively quantify this gap. The study evaluates bacterial penetration and subsequent symptoms of infection of traditional sutures and an emerging tape-based, zip-type wound closure technology under physiologically relevant loading. In an in vivo model to simulate real-world conditions, the latter demonstrates better performance compared to commonly used sutures, holding the wound intact and minimizing bacterial penetration when subjected to simulated patient movement-induced stress.
Intron-mediated alternative splicing of Arabidopsis P5CS1 and its association with natural variation in proline and climate adaptation (2012)

Drought-induced proline accumulation is widely observed in plants but its regulation and adaptive value are not as well understood. Proline accumulation of the Arabidopsis accession Shakdara (Sha) was threefold less than that of Landsberg erecta (Ler) and quantitative trait loci mapping identified a reduced function allele of the proline synthesis enzyme Δ(1)-pyrroline-5-carboxylate synthetase1 (P5CS1) as a basis for the lower proline of Sha. Sha P5CS1 had additional TA repeats in intron 2 and a G-to-T transversion in intron 3 that were sufficient to promote alternative splicing and production of a nonfunctional transcript lacking exon 3 (exon 3-skip P5CS1). In Sha, and additional accessions with the same intron polymorphisms, the nonfunctional exon 3-skip P5CS1 splice variant constituted as much as half of the total P5CS1 transcript. In a larger panel of Arabidopsis accessions, low water potential-induced proline accumulation varied by 10-fold and variable production of exon 3-skip P5CS1 among accessions was an important, but not the sole, factor underlying variation in proline accumulation. Population genetic analyses suggest that P5CS1 may have evolved under positive selection, and more extensive correlation of exon 3-skip P5CS1 production than proline abundance with climate conditions of natural accessions also suggest a role of P5CS1 in local adaptation to the environment. These data identify a unique source of alternative splicing in plants, demonstrate a role of exon 3-skip P5CS1 in natural variation of proline metabolism, and suggest an association of P5CS1 and its alternative splicing with environmental adaptation.
Robot-Assisted Epicardial Ultrasound for Coronary Artery Localization and Anastomosis Quality Assessment in Totally Endoscopic Coronary Bypass Surgery (2008)

Epicardial ultrasound can successfully locate and assess the coronary arteries and assess anastomotic quality in the porcine TECAB model within a few minutes. It therefore is a promising tool to help advance TECAB, but clinical confirmation of the experimental results remains to be established.
Analysis of axial spatial resolution in a variable resolution x-ray cone beam CT (VRX-CBCT) system (2008)

The Variable Resolution X-ray (VRX) technique has been successfully used in a Cone-Beam CT (CBCT) system to increase the spatial resolution of CT images in the transverse plane. This was achieved by tilting the Flat Panel Detector (FPD) to smaller <i>vrx<sub>y</sub></i> angles in a VRX Cone Beam CT (VRX-CBCT) system. In this paper, the effect on the axial spatial resolution of CT images created by the VRX-CBCT system is examined at different <i>vrx<sub>x</sub></i> angles, where <i>vrx<sub>x</sub></i> is the tilting angle of the FPD about its x-axis. An amorphous silicon FPD with a CsI scintillator is coupled with a micro-focus x-ray tube to form a CBCT. The FPD is installed on a rotating frame that allows rotation of up to 90&deg; about x and y axes of the FPD. There is no rotation about the z-axis (i.e. normal to the imaging surface). Tilting the FPD about its x-axis (i.e. decreasing the <i>vrx<sub>x</sub></i> angle) reduces both the width of the line-spread function and the sampling distance by a factor of sin <i>vrx<sub>x</sub></i>, thereby increasing the theoretical detector pre-sampling spatial resolution proportionately. This results in thinner CT slices that in turn help increase the axial spatial resolution of the CT images. An in-house phantom is used to measure the MTF of the reconstructed CT images at different <i>vrx<sub>x</sub></i> angles.
A Loop-Shaping Method for Frequency-Based Design of Layer-to-Layer Control for Laser Metal Deposition (2020)

Additive manufacturing processes fabricate parts in a layer-by-layer fashion, depositing material along a predefined path before incrementing to the next layer. Although the thickness of any given layer is bounded, in-layer dynamics can couple with layer-to-layer dynamics such that height defects amplify from one layer to the next. This is considered instability in the layer domain. By considering each layer as an iteration, additive processes can be categorized as repetitive processes. Although Repetitive Process Control (RPC) algorithms exist that can stabilize the process and converge to desired reference, it is typically assumed that the reference and disturbance are constant from layer to layer. In this paper, the problem of tracking references (layer thicknesses) that change from layer to layer is considered. The bandwidth of the changing references is considered bounded in both the spatial and layer domains. A loop-shaping design process is then considered, in which the bounds are mapped to a bound on the two-dimensional sensitivity function and projected onto weighting filters in an LQR control formulation. The layer-to-layer controller is then constructed from traditional LQR methods. The controller is demonstrated on a simulation of laser metal deposition for a wavy wall build having frequency content in both the spatial and layer domains.
Caution when using 1,3, β-D-glucan in the CSF as a biomarker of Candida albicans meningitis (2022)

Relying on a biomarker to diagnose or follow up the treatment of a Candida albicans meningitis would have an impact on patient management. The biomarker 1,3, β-D-glucan (BDG), developed for serum testing, shows inconsistent values when applied on cerebrospinal fluid (CSF), and its use with the current protocol on CSF samples warrants caution.
Dipyrone in pain management (1997)

In view of its long history, it is not surprising that dipyrone (metamizole) has been used for the relief of pain of a wide variety of different causes. In many countries, especially in Germany, dipyrone or Novalgin® is almost a household name. In common with the other non-acidic, non-opioid analgesic paracetamol, past use often outstripped the clinical documentation of efficacy. However, publications on many randomized, double-blind controlled studies are now available in which dipyrone has been investigated in comparison to paracetamol or Opioids for mild to moderate pain. Some of these studies are reviewed here to demonstrate the variety of painful conditions in which dipyrone has been shown to be effective, and more are available in the literature [1–9].
Elastic Liposomal Formulation for Sustained Delivery of Antimigraine Drug: In Vitro Characterization and Biological Evaluation (2008)

The aim of this study was to prepare and characterize a topical formulation for sustained delivery of rizatriptan. Elastic liposomal formulation of rizatriptan was prepared and characterized for different characteristics by evaluating in vitro and in vivo parameters. The in vivo performance of optimized formulation was evaluated for antimigraine activity in mice using morphine withdrawal-induced hyperalgesia. The in vitro skin permeation study across rat skin suggested carrier-mediated transdermal permeation for different elastic liposomal formulation to range between 18.1 +/- 0.6 and 42.7 +/- 2.3 microg/h/cm(2), which was approximately 8-19 times higher than that obtained using drug solution. The amount of drug deposited was 10-fold higher for elastic liposome (39.9 +/- 3.2%) than using drug solution (3.8 +/- 1%); similarly the biological activity of optimized elastic liposome formulation was found to be threefold higher than the drug solution. On the basis of the results, it can be concluded that the elastic liposomal formulation provided sustained action of rizatriptan due to depot formation in the deeper layer of skin.
Impulsive stimulated Brillouin microscopy for high-speed biomedical diagnostics (Conference Presentation) (2023)

Impulsive stimulated Brillouin microscopy (ISBS) is a technique that promises to enable fast measurements of the viscoelastic properties of biological samples. Its big advantage compared to spontaneous Brillouin arises from the capability to manipulate the signal-to-noise ratio by the choice of the system parameters. In this contribution, we will present a thorough analysis of the signal generation dependencies and the resulting implications on the spatiotemporal resolution. First measurements on blood, water and hydrogels underline the potential of the technique and show that ISBS can be an important alternative for selected biomedical applications.
Further Highly Oxygenated Guaiane Lactones from the South China Sea Gorgonian Menella sp. (2008)

Abstract Four new highly oxygenated guaiane lactones, 1‐epimenverin B ( 1 ), menverin F ( 2 ), 1‐deoxymenverin F ( 3 ), and menverin G ( 4 ), together with the two known related analogues menverins B ( 5 ) and C ( 6 ), were isolated from the South China Sea gorgonian Menella sp. Their structures and relative configuration were elucidated by analysis of spectroscopic data and by comparison with those of known related compounds.
Spectroscopic Ellipsometry and Microstructure Characterization of Photochromic Oxygen‐Containing Yttrium Hydride Thin Films (2018)

Oxygen‐containing yttrium hydride, YH x :O y , is an inorganic phothochromic material which exhibits promising features for its application in smart windows, ophthalmic lenses, and many more. In the present work the optical properties of photochromic and non‐photochromic YH x :O y thin films prepared by magnetron sputtering are studied by variable angle ellipsometry and spectrophotometry. These include the study of the complex refractive index, the transmittance, and luminous transmittance, as well as the reflectance of a selection of samples of diverse structural properties obtained under different deposition conditions. In the case of the photochromic YH x :O y thin films, the refractive index in the near infrared and visible regions is found similar to the one corresponding to yttrium oxide, Y 2 O 3 . However, the YH x :O y films exhibit a smaller band gap and hence higher absorption in the near ultraviolet than Y 2 O 3 . The photodarkening potential of the films are also quantified and characterized by the study and modeling of their optical properties before and after illumination. Our results show that photochromic YH x :O y films, with a luminous transmittance above 80 % in the clear state, can reduce its transparency up to a 30% after 1 h illumination at 1 Sun.
Margin measurements in optical amplifier system (1993)

The margin, or the difference between the received signal-to-noise (SNR) and the SNR required to maintain a given bit error ratio (BER), is important to the design and operation of optical amplifier transmission systems A new tehnique is described for estimating the SNR at the receiver's decision circuit when the BER is too low to be measured in a reasonable time. The SNR is determined from the behavior of the BER as a function of the decision threshold setting in the region where the BER is measurable. The authors obtain good agreement between the BER predicted using the measured SNR value and the actual measured BER.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Chemistry of alkyl thiolsulfinate esters. IV. Mechanistic study of the disproportionation reaction (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of alkyl thiolsulfinate esters. IV. Mechanistic study of the disproportionation reactionEric. Block and Stuart W. WeidmanCite this: J. Am. Chem. Soc. 1973, 95, 15, 5046–5048Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/ja00796a047https://doi.org/10.1021/ja00796a047research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
3D Acoustic Analysis Using an Iterative Multilevel Meshless Method (2002)

info:eu-repo/semantics/published
Monitoring of Cardiac Function in Patients With a Left Ventricle Assist Device (1998)

In complex therapy of acute or chronic cardiac failure, the use of valve-free centrifugal pumps or artificial heart ventricles takes place. In these cases, simultaneous monitoring of cardiac and pump performance is very important. In this study, an ultrasound dilution method based on the registration of two dilution curves after intravenous injection of isotonic and hypertonic sodium solution was developed. Comparison of total cardiac output (TCO), which included pump and heart output measured by thermodilution and ultrasound (TCOus) dilution, yielded TCOus = 1.11TCOth - 0.54 (n = 13).
Preparation, Characterization, and Biological Activity of Amides and Esters from 8-Hydroxyquinoline-2-Carboxylic Acid and Jeffamines ED® Or Poly(Ethylene Glycol)S (2001)

New macromolecular chelators were synthesized under mild conditions by reaction of 8-hydroxyquinoline-2-carboxylic acid (8Q2COOH) with polyethers having amino end-groups (Jeffamines ED®) or poly(ethylene glycol)s in the presence of dicyclohexylcarbodiimide and dimethylamino-pyridine. The prepared amides (8Q2CONH-POE) and esters (8Q2COO-POE) were characterized by SEC, DSC, IR, 1 H and 13 C NMR spectroscopy, and MALDI-TOF mass spectrometry. It was found that the polyethers had 8-hydroxy-2-quinolinyl end groups and formed complexes with Fe 3+ ions. The obtained complexes were studied with IR spectroscopy and DSC. The plant tests showed that the Fe 3+ complex of 8Q2CONH-POE 2000 had high efficacy in the remedy of iron-deficient maize plants under hydroponic conditions.