gebhart/patrepeval huggingface dataset:
Reduced levels of N-terminal-proatrial natriuretic peptide in hypertensive patients with metabolic syndrome and their relationship with left ventricular mass (2007)

The present study demonstrates that levels of NT-proANP are significantly reduced in hypertensive patients affected by MS, and they are significantly inversely related to the increased LVM observed in these patients. Our findings, while supporting previous experimental and clinical evidence of the antihypertrophic role of ANP in hypertension, may help to identify one of the possible mechanisms directly underlying LVH in MS.
Separation of benzene and nitrogen by permeation through porous Vycor Glass. (1985)

外径17mm, 長さ50mm, 厚さ1.4mmの多孔質Vycorガラスの外側にベンゼン-窒素の混合気体を送り, 内側へ透過させた.取出側の流れが混合拡散を伴うピストン流であると考えることにより, ベンゼンの透過係数のバラツキを小さくすることができた.透過係数にアレニウス型の温度依存性を考え, 測定温度における飽和蒸気圧で無次元化した供給側と取出し側の平均分圧に対してプロットすると一本の線で表すことができた.窒素の透過係数は無次元化した供給側のベンゼン分圧で整理することができ, 無次元ベンゼン蒸気圧が0.4程度 (毛管凝縮蒸気圧に相当する) までは岡崎らの式でその挙動を表すことができたが, それ以上では毛管凝縮による細孔の閉塞のため透過係数の低下が著しかった.この部分の挙動を毛管凝縮量と関係づけるモデルを作ったところ実測との一致は良かった.この結果, ベンゼンと窒素の分離係数として10ないし3000という大きな値が得られた.表面拡散係数についての整理も行った.
Accurate and continuous non-contact vital signs monitoring using phased array antennas in a clutter-free anechoic chamber (2013)

Continuous and accurate monitoring of human vital signs is an important part of the healthcare industry, as it is the basic means by which the clinicians can determine the instantaneous status of their patients. Doppler-based noncontact vital signs (NCVS) sensor systems can monitor the heart and respiration rates without touching the patient, but it has been observed that that the accuracy of these NCVS sensors can be diminished by reflections from background clutters in the measurement environment, and that high directivity antennas can increase the sensing accuracy. Therefore, this work explores a NCVS sensor with continuous data taken inside an anechoic chamber where the background cluttering is negligible. In addition, a high directivity custom-made beam-steerable phased array antenna system is used to improve the performance and functionality of the 2.4GHz NCVS sensor we have built. We believe this work is the 1st systematic study using Doppler-based phased array systems for NCVS sensing performed in a clutter-free anechoic chamber.
Flatness-based-control for parallel operation of N voltage-source inverters (2013)

Parallel voltage-source inverters with common dc bus present very interesting advantages from an industrial point of view. Indeed, by paralleling several units the power supply system includes capability to handle high power requirement, modularity and the possibility of maintenance through redundancy, within an uninterruptible supply operation. However, a special attention is required to avoid the negative effect of the circulating currents in such configuration caused essentially by the asynchronous switching operations of the Pulse Width Modulations (PWM) specified to each unit. To deal with this problem, in this contribution a one loop controller based on the flatness technique is proposed to an isolated power supply composed by N units. These units connect the same dc source and the ac load. The objective of the new sharing controller is to take some advantages of the flat proprieties of the system in order to ensure both reduction of the circulating currents and high power quality at the Point of Common Connection (PCC).
Group VIII metal-catalyzed reactions of organosilicon hydrides with amines, hydrogen halides, and hydrogen sulfide (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGroup VIII metal-catalyzed reactions of organosilicon hydrides with amines, hydrogen halides, and hydrogen sulfideLeo H. Sommer and Joel D. CitronCite this: J. Org. Chem. 1967, 32, 8, 2470–2472Publication Date (Print):August 1, 1967Publication History Published online1 May 2002Published inissue 1 August 1967https://pubs.acs.org/doi/10.1021/jo01283a025https://doi.org/10.1021/jo01283a025research-articleACS PublicationsRequest reuse permissionsArticle Views482Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimization of extrusion based ceramic 3D printing process for complex bony designs (2018)

In this study presents materials and design optimization of clinically approved hydroxyapatite (HA) using extrusion based 3D printing process. The effect of various printing parameters including print speed, extrusion pressure, accuracy and infill density to produce defined porous structures is established using various techniques. Particularly Scanning Electron Microscopy, Micro Computed Tomography have been employed to study internal and external accuracy. Mechanical testing was employed to study the effect of porosity on compressive properties of 3D printed structures. This study shows that, the infill density and shrinkage of 3D printed HA scaffolds post sintering have a linear relationship. Porosity and mechanical strength of 3D printed scaffolds depend on the infill density of the designed CAD file. Tailoring infill density also helps in altering mechanical properties in a predictable manner. Finally, a case study on hydroxyapatite printing of a patient specific bone graft demonstrates the ability of this material and technique to print complex porous structures created on CT-based anatomical bone models and pre-operative 3D planning, providing further promise for custom implant development for complex bony designs.
Simulated Annealing Algorithm-Based Inversion Model To Interpret Flow Rate Profiles and Fracture Parameters for Horizontal Wells in Unconventional Gas Reservoirs (2021)

Summary With the increasing application of distributed temperature sensing (DTS) in downhole monitoring for multifractured horizontal wells (MFHWs), well performance interpretation by inversing DTS data has become a popular topic around the world. However, because of the lack of efficient inversion models, great challenges still exist in interpreting flow rate profiles and fracture parameters for MFHWs in unconventional gas reservoirs from DTS data. In this paper, a robust inversion system is developed to interpret flow rate profiles and fracture parameters for MFHWs in unconventional gas reservoirs by inversion of DTS data. A temperature prediction model serves as a forward model to simulate the temperature behaviors of MFHWs. A new inversion model based on a simulated annealing (SA) algorithm is proposed to find inversion solutions to flow rate profiles and fracture parameters. The simulated results of temperature behaviors indicate that the temperature profile of each MFHW is irregularly serrated, and the temperature drop in each serration is positively correlated with the inflow rate and fracture half-length. These results provide an excellent method to identify and locate effective hydraulic fractures for field MFHWs. Because of the far more significant influence of fracture half-length than conductivity on a temperature profile, fracture half-length was chosen as the inversion target parameter when performing the inversion of DTS data for MFHWs. Then a synthetic inversion task was accomplished using the SA algorithm-based inversion system, and it took only 110 iterations to reach the target inversion accuracy (10−6 level). Real-time inversion error distributions indicate that this novel inversion system shows great advantages in computational efficiency. Finally, a field application in a shale gas reservoir is presented to validate the reliability of the new inversion model. Based on accurate identification of effective fractures from DTS profiles, satisfactory inversion solutions (the maximum temperature deviation of less than 0.03 K) are obtained. The absolute error of the inversed gas production rate is less than 4 m3/d. The SA algorithm-based inversion system proves reliable to interpret flow rate profiles and fracture parameters, which is a great help to postfracturing evaluation and productivity improvement for MFHWs in unconventional gas reservoirs.
Off-the-record email system (2002)

In the flood of communications now carried via email, it frequently happens that users want to keep some casual or sensitive exchanges off the record, just as in ordinary telephone conversations. Within the system architectures commonly in use today, however, virtually all email transmissions leave a permanent record behind-a paper trail-that is extremely difficult to obliterate. Even after an email is "deleted" by both the sender and the recipient, a copy will likely remain in backup storage at one or more of the email servers that handled the message during its lifetime. Encryption does not solve the problem, because the message can be recovered if the decryption key is revealed, perhaps under court order, or for some other reason. To ensure email privacy, an off-the-record email system is proposed. In this system, the email stays in the sender's computer and is read by the recipient through a Web browser over a secure connection. The message content cannot be recovered from an encrypted copy even with the help of both parties' private keys. Further, the email has a limited lifetime. After it is deleted from the sender's computer, it cannot be recovered from any remaining backup records. The new system is completely compatible with current email implementations. Using existing tools, email users can conduct secure, off-the-record communications. Two practical implementations are given to demonstrate how to deploy off-the-record email both in an intranet as well as on the Internet.
Explaining complex codon usage patterns with selection for translational efficiency, mutation bias, and genetic drift (2011)

The genetic code is redundant with most amino acids using multiple codons. In many organisms, codon usage is biased toward particular codons. Understanding the adaptive and nonadaptive forces driving the evolution of codon usage bias (CUB) has been an area of intense focus and debate in the fields of molecular and evolutionary biology. However, their relative importance in shaping genomic patterns of CUB remains unsolved. Using a nested model of protein translation and population genetics, we show that observed gene level variation of CUB in Saccharomyces cerevisiae can be explained almost entirely by selection for efficient ribosomal usage, genetic drift, and biased mutation. The correlation between observed codon counts within individual genes and our model predictions is 0.96. Although a variety of factors shape patterns of CUB at the level of individual sites within genes, our results suggest that selection for efficient ribosome usage is a central force in shaping codon usage at the genomic scale. In addition, our model allows direct estimation of codon-specific mutation rates and elongation times and can be readily applied to any organism with high-throughput expression datasets. More generally, we have developed a natural framework for integrating models of molecular processes to population genetics models to quantitatively estimate parameters underlying fundamental biological processes, such a protein translation.
Lung fibrosis induced by Thorotrast. (1990)

A 63 year old woman developed progressive shortness of breath, pulmonary hypertension, and respiratory failure and died from pulmonary fibrosis 45 years after thoracic fistulography with Thorotrast. Bouts of acute respiratory failure occurred with features of noncardiogenic pulmonary oedema. Lung tissue obtained by biopsy and at necropsy showed abundant radioactive particles of thorium dioxide in the lungs. The particles were congregated in the walls of blood vessels and in perivascular fibrous zones, consistent with a causal role of Thorotrast in the development of lung fibrosis. It is suggested that the fibrosis was due to the combined effects of alpha radiation on the interstitial perivascular zones and of recurrent pulmonary oedema due to endothelial damage.
In vivo full-field en face correlation mapping optical coherence tomography (2013)

A full-field optical coherence tomography (OCT) system has been developed for the purpose of performing nonscanning en face flow imaging. The light source is centered at 840 nm with a bandwidth of 50 nm resulting in an axial resolution of 8 μm in air. Microscope objectives with a numerical aperture of 0.1 were incorporated giving a transverse resolution of 5 μm. A magnification of 5.65 was measured, resulting in a field of view of 1260×945 μm. Pairs of interference fringe images are captured with opposing phase and a two-step phase image reconstruction method is applied to reconstruct each en face image. The OCT frame rate is 10 Hz. A two-dimensional cross-correlation technique is applied to pairs of consecutive en face images in order to distinguish dynamic from static light-scatterers. The feasibility of the method was examined by simulating blood flow by creating a phantom with 5% intralipid solution. In vivo imaging of a Xenopus laevis tadpole was also performed in order to investigate the feasibility of imaging the vascular system. We present for what we believe to be the first time, the application of correlation mapping optical coherence tomography to full-field OCT to provide in vivo functional imaging of blood vessels.
Size Tuning, Functionalization, and Reactivation of Au in TiO2 Nanoreactors (2005)

Reactor core: Hollow core–shell Au–TiO2 nanocomposites can be prepared by a wet chemical method to form reactors that contain a catalyst core with a shell that is permeable to reactants. The core can be enlarged, and modification of the synthesis produces flowerlike nanostructures (see picture). Catalytic reactions in both the gaseous and liquid phase can be conducted in this type of photosensitized metal–semiconductor nanoreactor. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500394_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages (2021)

Bacterial infections are a common and deadly threat to vulnerable patients. Alternative strategies to fight infection are needed. β-Glucan, an immunomodulator derived from the fungal cell wall, provokes resistance to infection by inducing trained immunity, a phenomenon that persists for weeks to months. Given the durability of trained immunity, it is unclear which leukocyte populations sustain this effect. Macrophages have a life span that surpasses the duration of trained immunity. Thus, we sought to define the contribution of differentiated macrophages to trained immunity. Our results show that β-glucan protects mice from <i>Pseudomonas aeruginosa</i> infection by augmenting recruitment of innate leukocytes to the site of infection and facilitating local clearance of bacteria, an effect that persists for more than 7 d. Adoptive transfer of macrophages, trained using β-glucan, into naive mice conferred a comparable level of protection. Trained mouse bone marrow-derived macrophages assumed an antimicrobial phenotype characterized by enhanced phagocytosis and reactive oxygen species production in parallel with sustained enhancements in glycolytic and oxidative metabolism, increased mitochondrial mass, and membrane potential. β-Glucan induced broad transcriptomic changes in macrophages consistent with early activation of the inflammatory response, followed by sustained alterations in transcripts associated with metabolism, cellular differentiation, and antimicrobial function. Trained macrophages constitutively secreted CCL chemokines and robustly produced proinflammatory cytokines and chemokines in response to LPS challenge. Induction of the trained phenotype was independent of the classic β-glucan receptors Dectin-1 and TLR-2. These findings provide evidence that β-glucan induces enhanced protection from infection by driving trained immunity in macrophages.
A standalone neural network based electronic nose (1992)

The authors describe on going work which is concerned with the application of artificial neural networks in instrumentation systems such as the electronic nose. They describe a neural network simulator system which will facilitate the design of standalone neural networks based systems. Their work continues in areas such as the use of other neural net paradigms, automatic net design techniques and hardware nets. >
Magnetic Localization of Buried Cable by the SCARAB Submersible (1981)

A magnetometer array has been installed aboard the SCARAB submersible to enable it to detect and track buried undersea telephone cable. Four three-axis magnetometers sense the magnetic field of a 25-Hz current applied to the cable. The magnetometer signals are filtered, amplified, digitized, and multiplexed onto SCARAB's umbilical cable for transmission to the control ship. A shipborne minicomputer processes these signals in real time to determine the cable location, which is continuously displayed to SCARAB's operator on a graphics terminal. This paper describes the development and capabilities of the system. Among the topics discussed are a history of the cable-locating problem, an analysis of the factors governing the achievable 25-Hz signal level, a description of the magnetic noise spectrum and its sources, and a discussion of the signal-processing techniques. We also examine the dependence of system performance on signal and noise levels.
A prospective randomised study of continuous warm versus intermittent cold blood cardioplegia for coronary artery surgery: preliminary report (1994)

Between October 1991 and March 1993, 281 consecutive patients underwent non-emergency isolated coronary artery surgery under the care of one surgeon (A.R.). They were prospectively randomised to receive either intermittent cold (Group I-144 patients) or continuous warm (Group II-137 patients) blood cardioplegia for myocardial protection. There were no significant differences in clinical outcome between the two groups, as judged by operative mortality, rates of peri-operative myocardial infarction, blood loss, need for circulatory support, post-operative neurological deficit, or duration of intensive care or hospital stay. However, sinus rhythm returned spontaneously with greater frequency (91.2% vs 45.8%, P < 0.001) in Group II patients. There was greater transmyocardial oxidative stress in Group I patients, as evidenced by a significant rise in oxidised glutathione in coronary sinus blood on myocardial reperfusion. Also, the serum CKMb isoenzyme level 2 h post-operatively was significantly raised in Group I patients, although this difference had disappeared by the day after surgery. In conclusion this preliminary report suggests that continuous warm blood cardioplegia provides comparable myocardial protection to that achieved with standard hypothermic techniques in patients undergoing coronary artery surgery.
Force-Stiffness Feedback in Uninhabited Aerial Vehicle Teleoperation with Time Delay (2009)

This study investigates the use of haptic feedback to support the teleoperation of an uninhabited aerial vehicle with time delay. Two means of supplying the haptic feedback are investigated: first, an additional force on the control inceptor, and second, an additional force combined with an increased stiffness of the control inceptor. The advantage of combining the force feedback with stiffness feedback, over force feedback alone, is that the additional stiffness of the control inceptor increases the authority of the haptic feedback system in critical situations. The goal of this study is to increase the safety of teleoperation while reducing operator workload. A theoretical analysis shows that force― stiffness feedback improves the stability in the human control loop while allowing for lower force-feedback gain settings as compared with force feedback alone, which indicates that this could contribute to reducing operator workload. In an experiment, the two haptic feedback conditions were compared with a baseline condition without haptic feedback. The fidelity of the experiment was improved over an earlier experiment by introducing a time penalty for collisions. The number of collisions was different for all three conditions, with the lowest number for the force―stiffness condition and the highest number for the baseline condition. Both haptic feedback conditions were rated equally on subjective workload metrics and scored better than the baseline. This finding is in contrast with results from earlier experiments, which indicated a higher workload with haptic feedback, and shows the importance of creating realistic test conditions when using subjective workload ratings.
Lake Forest Students Present Their Research at Regional and National Symposia (2007)

During the fall of 2006, undergraduates from Lake Forest College (LFC), including myself [Michael White], organized their research into posters and PowerPoint presentations to exhibit at regional and national academic symposia. Specifically, participants conducted laboratory or field research on either Parkinson’s disease, cell volume regulation, RNAi, addiction, or avian biology. Fourteen LFC students presented this great diversity of biological study at the Argonne National Laboratories Undergraduate Symposium in lecture form. Lokesh Kukreja, Michael Zorniak, and myself went a step further and traveled to San Diego, California to present two posters on our fission and budding yeast models of Parkinson’s disease at the American Society for Cell Biology. Whether presenting on the regional or national scale, young scientists from LFC demonstrated their individual research in biology and enjoyed the fellowship of other undergraduate and graduate students.
A probe for octopamine receptors. Synthesis of 2-[(4-azido-2,6-diethylphenyl)imino]imidazolidine and its tritiated derivative, a potent reversible irreversible activator of octopamine-sensitive adenylate cyclase (1989)

In order to develop an irreversible ligand for octopamine receptors, a highly potent azido-substituted 2-(phenyl-imino)imidazolidine (NC-5Z, 8) and its tritiated derivative (3H-NC-5Z, 11) have been designed and synthesized. Under reversible-binding conditions, NC-5Z is 50-100-fold more potent than octopamine in activating octopamine-sensitive adenylate cyclase in a variety of tissues. After photolysis, 3H-NC-5Z binds irreversibly to cell membranes, and this binding is reduced by preincubation with octopamine agonists and antagonists but not by norepinephrine, dopamine, serotonin, or histamine. NC-5Z should be useful both as a potent reversible octopamine agonist and as an affinity probe for characterizing and isolating octopamine-receptor proteins.