gebhart/patrepeval huggingface dataset:
Effect of (Z)-11-[3-(dimethylamino) propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride on experimental allergic conjunctivitis and rhinitis in rats and guinea pigs. (1995)

The effect of KW-4679 (Z)-11-[3-(dimethylamino) propylidene]-6,11-dihydrodibenz [b,e] oxepin-2-acetic acid hydrochloride, CAS 140462-76-6; proposed INN: olopatadine) on experimental conjunctivitis and rhinitis was studied in comparison with that of ketotifen (CAS 34580-14-8) using guinea pigs and rats, respectively. KW-4679 was effective in inhibiting the antigen- and histamine-induced conjunctivitis by both oral and topical administrations. These effects of KW-4679 were somewhat more potent than those of ketotifen. KW-4679 as well as ketotifen was more effective in inhibiting the histamine-induced conjunctivitis than that seen in antigen-induced conjunctivitis when they were given topically. KW-4679 inhibited the increased dye leakage into the nasal cavity induced not only by antigen in actively sensitized rats but also by histamine perfusion in non-sensitized rats by oral and topical administrations. Similar to ketotifen, the effect of KW-4679 on histamine-induced increase in dye leakage was almost same as that induced by antigen. The potency of KW-4679 was higher than that of ketotifen in the increased dye leakage induced by both antigen and histamine perfusion.
Stability of Chimerism in Non-Obese Diabetic Mice Achieved By Rapid T Cell Depletion Is Associated With High Levels of Donor Cells Very Early After Transplant (2018)

Stable mixed hematopoietic chimerism is a robust method for inducing donor-specific tolerance with the potential to prevent rejection of donor islets in recipients with autoimmune type-1 diabetes. However, with reduced intensity conditioning, fully allogeneic chimerism in a tolerance resistant autoimmune-prone non-obese diabetic (NOD) recipient has rarely been successful. In this setting, successful multilineage chimerism has required either partial major histocompatability complex matching, mega doses of bone marrow, or conditioning approaches that are not currently clinically feasible. Irradiation free protocols with moderate bone marrow doses have not generated full tolerance; donor skin grafts were rejected. We tested whether more efficient recipient T cell depletion would generate a more robust tolerance. We show that a combination of donor-specific transfusion-cyclophosphamide and multiple T cell depleting antibodies could induce stable high levels of fully allogeneic chimerism in NOD recipients. Less effective T cell depletion was associated with instability of chimerism. Stable chimeras appeared fully donor-specific tolerant, with clonal deletion of allospecific T cells and acceptance of donor skin grafts, while recovering substantial immunocompetence. The loss of chimerism months after transplant was significantly associated with a lower level of chimerism and donor T cells within the first 2 weeks after transplant. Thus, rapid and robust recipient T cell depletion allows for stable high levels of fully allogeneic chimerism and robust donor-specific tolerance in the stringent NOD model while using a clinically feasible protocol. In addition, these findings open the possibility of identifying recipients whose chimerism will later fail, stratifying patients for early intervention.
Modeling cost/performance of a parallel computer simulator (1997)

This article examines the cost/performance of simulating a hypothetical target parallel computer using a commercial host parallel computer. We address the question of whether parallel simulation is simply faster than sequential simulation, or if it is also more cost-effective. To answer this, we develop a performance model of the Wisconsin Wind Tunnel (WWT), a system that simulates cache-coherent shared-memory machines on a message-passing Thinking Machines CM-5. The performance model uses Kruskal and Weiss's fork-join model to account for the effect of event processing time variability on WWT's conservative fixed-window simulation algorithm. A generalization of Thiebaut and Stone's footprint model accurately predicts the effect of cache interference on the CM-5. The model is calibrated using parameters extracted from a fully parallel simulation (p = N), and validated by measuring the speedup as the number of processors (p) ranges from 1 to the number of target nodes (N). Together with simple cost models, the performance model indicates that for target system sizes of 32 nodes and larger, parallel simulation is more cost-effective than sequential simulation. The key intuition behind this result is that large simulations require large memories, which dominate the cost of a uniprocessor; parallel computers allow multiple processors to simultaneously access this large memory.
Five-Point Relative Orientation Based on Forward Intersection (2015)

The algorithm of five- point relative orientation is a classical problem for photogrammetry and computer vision. The polynomial is used by the traditional method of five- point relative pose, which causes the polysemia. Therefore, a new method of five-point relative orientation based on the forward intersection is presented, the coplanar equations with forward intersection constraints are set up, whose optimization function is derived, and the least square generalized inverse method is employed to achieve relative orientation parameters with five homologous points. This method has been demonstrated by 8 groups of experiments which use nonmetric camera Nikon D80, the relative three dimensional (3D) model successfully only with 5 homologous points of two images with different view angles, and the standard uncertainty of measured errors for the two given rules (0.92 m) is 0.28±0.24 mm. Compared with the existing five-point algorithm, this method can ensure the intersections for the five homologous rays without polysemia, its accuracy and robustness is good, and has practical value. ©, 2015, Chinese Optical Society. All right reserved.
Role of the Alkali Metal Cation in the Early Stages of Crystallization of Halide Perovskites (2022)

ABX3 metal halide perovskites revolutionized the research and development of new optoelectronics, including solar cells and light-emitting diodes. Processing polycrystalline thin films from precursor solutions is one of the core advantages of these materials since it enables versatile and cost-effective manufacturing. The perovskite film morphology, that is, continuous substrate coverage and low surface roughness, is of paramount importance for highly efficient solar cells and optoelectronic devices in general. Controlling the chemistry of precursor solutions is one of the most effective strategies to manage the perovskite film morphology. Herein, we show the fundamental influence of the A-site cation composition on the perovskite precursor arrangement and the consequent film formation. Extended X-ray absorption fine structure spectroscopy and small-angle X-ray scattering give unprecedented insights into the complex structural chemistry of the perovskite precursors and, in particular, their repulsive interactions as a crucial parameter for colloidal stability. Combining these techniques with in situ grazing incidence wide-angle X-ray scattering during thin-film formation allows us to identify the mechanism for using alkali metals as a decisive criterion to control the colloidal stability of the perovskite precursor and thus the thin-film morphology. We illustrate the fundamental principle behind the systematic use of alkali metals regardless of whether they are incorporated in the lattice or not. Hence, this work provides tools to selectively control the morphology and crystal growth in present and future systems.
Neural Network Based Approach for Tuning Kalman Filter (2006)

Kalman filter (KF) parameter tuning has been dealt with in a limited fashion and usually was left to engineering intuition due to unavailable measurements of process noise and high dimensionality of the problem. In this paper we present a simple Neural Network (NN) based approach to KF tuning problem. Since the approach trades number of KF runs required for the optimal filter tuning for KF performance, the result of the such tuning is the set of tuning parameters that gives suboptimal performance. Advantages of this approach are: 1) simple practical framework for optimal filter performance tuning, 2) the framework is independent of the type of a filter and 3) low number of filter runs required to obtain quasi optimal parameter set. The main disadvantage is the suboptimal filter performance that can be easily improved by increasing the number of filter runs. Two NN architectures were investigated, generalized regression neural network (GRNN) and regular radial basis networks (RBNN). RBNN showed much better performance for a given non-linear test function with a clear maximum peak. Performance measures along with computational efficiency for these methods were compared. A step-by-step tuning procedure is presented.
4‐Substituted Indazoles as New Inhibitors of Neuronal Nitric Oxide Synthase. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Acid-Promoted Reactions of Schiff’s Bases with Ketene Dithioacetal, Vinyl Sulfides, and 1,2-Propadienyl Sulfides (1992)

Abstract Several types of addition reactions proceed between Schiff’s bases and olefinic nucleophiles containing an alkylthio substituent. Ketene dithioacetal or 2-(methylthio)allylsilane reacts with Schiff’s bases in the presence of trifluoromethanesulfonic acid to afford β-amino acid equivalents or homoallylic amines, respectively. On the other hand, ene reaction proceeds between 1-alkyl-1,2-propadienyl sulfides and Schiff’s bases by treatment with AlCl3, giving 1,3-dienes.
Rapid tip tracking with MRI by a limited projection reconstruction technique (1998)

To rapidly track invasive devices within MRI systems, a novel approach using a limited projection reconstruction technique is presented. Our method exploits the difference between images reconstructed from a limited number of projections and serves to depict the tip of a needle during its advancement. This method was implemented on a standard MRI system with a radial fast-spin-echo sequence and examined in phantom studies. We demonstrated that the proposed method could track the tip every 300 msec and the tip depicted by the present technique was consistently displaced along the needle by a small distance (5 mm).
On Bent and Semi-Bent Quadratic Boolean Functions (2005)

The maximum-length sequences, also called m-sequences, have received a lot of attention since the late 1960s. In terms of linear-feedback shift register (LFSR) synthesis they are usually generated by certain power polynomials over a finite field and in addition are characterized by a low cross correlation and high nonlinearity. We say that such a sequence is generated by a semi-bent function. Some new families of such function, represented by f(x)=/spl Sigma//sub i=1//sup (n-1)/2/c/sub i/Tr(x(2/sup i/)+1), n odd and c/sub i//spl isin/F/sub 2/, have recently (2002) been introduced by Khoo et al. We first generalize their results to even n. We further investigate the conditions on the choice of c/sub i/ for explicit definitions of new infinite families having three and four trace terms. Also, a class of nonpermutation polynomials whose composition with a quadratic function yields again a quadratic semi-bent function is specified. The treatment of semi-bent functions is then presented in a much wider framework. We show how bent and semi-bent functions are interlinked, that is, the concatenation of two suitably chosen semi-bent functions will yield a bent function and vice versa. Finally, this approach is generalized so that the construction of both bent and semi-bent functions of any degree in certain range for any n/spl ges/7 is presented, n being the number of input variables.
Stepwise Solid‐Phase Synthesis of Nucleopeptides (2004)

Abstract Phosphodiester‐linked peptide‐oligonucleotide conjugates (nucleopeptides) are obtained by stepwise solid‐phase procedures. The peptide is first assembled on a suitably derivatized solid matrix and the oligonucleotide is subsequently elongated at the free hydroxyl group of the linking amino acid. Temporary acid‐labile and permanent base‐labile protecting groups are combined. Careful choice of the protection scheme is required to prevent and minimize side reactions that may degrade the target molecule.
<title>Properties of plasma of volume nanosecond high-pressure discharge formed in non-uniform electric field</title> (2004)

Properties of plasma produced in volume nanosecond high-pressure discharge and its formation conditions under elevated pressure in air, nitrogen, krypton, argon, neon and gas mixtures Ar-N<sub>2</sub>, Ar-Xe, CO<sub>2</sub>-N<sub>2</sub>-He in the gap with the cathode having small curvature radius have been investigated. Time-amplitude characteristics and radiation spectra of plasma in different gases in the range of 230-600 nm were defined. Lasing in the gas mixture Ar-Xe at active length of 1.5 cm has been achieved by excitation through volume nanosecond high-pressure discharge. Comparison of spectral radiation in nitrogen, krypton, argon, and neon under pumping of mentioned gases by volume discharge in non-uniform electric field, by nanosecond e-beam, and by volume pulsed discharge in the uniform electric field with high initial voltage was made. Lasing has also been obtained in the gas mixture CO<sub>2</sub>-N<sub>2</sub>-He under pumping by e-beam initiated discharge. The electron beam was formed in a gas diode filled the same gas mixture.
The Comparison of Alexithymia and Spiritual Intelligence in Addicts, Addicts under Methadone Treatment, and Non-Addicts (2012)

Introduction: The purpose of the present study was to compare of the rate of alexithymia and spiritual intelligence in addicts, addicts under Methadone Treatment, and non-Addicts. Method: A causal-comparative research design was used. The study sample included 30 individuals under Methadone Treatment, 30 drug-dependent Addicted, and 30 non-addicted individuals selected by convenience sampling procedure. Toronto alexithymia scale and King's spiritual intelligence self-report inventory were administered among selected sample. Results: Findings revealed significant differences among addicted individuals and non-addicted adults also among individuals under methadone treatment and non-addicted adults in total alexithymia scores as well as on all three subscale scores. Furthermore, addicted individuals differed from those under methadone treatment in their scores on the subscale pertaining to difficulty in identifying feelings. Results also indicated differences among addicted individuals and those under methadone treatment in total spiritual intelligence and its four component scale scores, while addicted individuals differed from non-addicted individuals in total spiritual intelligence scores and only three of its component scale scores (personal meaning production, transcendental awareness, and conscious state expansion). Conclusion: Findings of this study indicate the advantages of the ability to control, emotional regulation and spiritual intelligence as a defense against addiction. By development of these characteristics addicts can be helped to gain relief from their addiction.
Aerosol-based deposition of broadband antireflective silica coating with closed mesoporous structure (2022)

Solar energy will be a crucial part of the sustainable, fossil free energy production of the future. A majority of this will be produced by solar collectors and photovoltaics. Important for the efficient utilization of the incident solar energy for both technologies are a cover glass with antireflective coatings giving it a high solar transmittance. In the current paper we describe the development of antireflective mesoporous silica coatings on low-iron float glass using the aerosol-based nFOG™ deposition technique. The coatings exhibit a hexagonal and closed pore structure, high smoothness, superhydrophilic properties (contact angle <5°) and consistent thicknesses of approximately 110 nm. This is in line with optimal thickness determined from simulations of the antireflective behavior. Low-iron float glass coated on both sides show a highly reproducible solar weighted transmittance of 95% in the wavelength range 300–2500 nm and an antireflective effect increasing with incident angle. The smoothness, closed pores and low contact angle indicate a high cleanability, which in combination with the high transmittance render a competitive broadband antireflective coating well adapted for solar glass applications.
Ceftazidime-avibactam activity against Gram-negative respiratory isolates collected between 2018 and 2019 (2022)

Gram-negative respiratory isolates collected in 2018-2019 showed high susceptibility to CAZ-AVI; CAZ-AVI represents a potential treatment option against infection caused by these organisms.
[Cognitive disorders and its correction in the acute period of ischemic stroke]. (2012)

The efficiency of using of original stimulating programs for correction of memory decline, attention impairment and optical-spatial gnosis disorders was evaluated in 100 post stroke patients with the degree of cognitive decline from mild cognitive impairment to mild dementia in the acute period of stroke. In addition to traditional methods of treatment, we applied training using computer programs within 20-30 minutes daily 5 times a week during 14 days. Efficiency of treatment was measured by the MMSE, the FAB, the Clock drawing test, Shulte's tables and a letter correction test. After the treatment, the statistically significant improvement of cognitive functions was found in the group of patients receiving the correction with computer programs.
Unbiased Combinatorial Genomic Approaches to Identify Alternative Therapeutic Targets within the TSC Signaling Network (2013)

Abstract : The long-term goal of this project is geared toward further defining the regulatory mechanisms impinging on the TSC-Rheb circuit and revealing therapeutic strategies to target this signaling network in genetic tumor syndromes and cancer. Specifically, we aim to establish a robust synthetic lethal screening method applied to the study of the TSC network, validate synthetic lethal pairs in an in vivo intestinal stem cell system, and determine whether synthetic lethal combinations found in Drosophila are relevant to mammalian networks. In the second year of funding we have made significant progress and generated the required mutant cell lines and performed a combinatorial screen that has led to some exciting leads that we are in the process of being validated in mammalian cells.
Photon assisted tunneling in pairs of silicon donors (2014)

The authors provide an experimental demonstration that an electron can tunnel between shallow phosphorus and antimony donors in Si at zero fields upon selective excitation of one of the centers by a THz pulse. These results show that the spin-to-charge conversion is practical with photon assisted tunnelling, as required for Kane-type quantum computing schemes
Preparation of N‐aryl‐2,4‐diaminopentanes by the ring opening reaction of 1‐aryl‐3,4,5,6‐tetrahydro‐2‐(1H)pyrimidinones (1981)

Abstract 1‐Aryl‐3,4,5,6‐tetrahydro‐2‐(1 H )pyrimidinones (I) underwent reductive ring opening reaction with lithium aluminum hydride to afford N ‐aryl‐2,4‐diaminopentanes (II) in good yields. On the other hand, 3,4,5,6‐tetrahydro‐3,4,6‐trimethyl‐1‐phenyl‐2‐(1 H )‐pyrimidinone (V) gave only cyclic diamine, 3,4,6‐trimethyl‐1‐phenylhexahydropyrimidine (VI), in 60% yield.
Observation of Macroscopic Quantum Tunneling in a SingleBi2Sr2CaCu2O8+δSurface Intrinsic Josephson Junction (2007)

We report on the first unambiguous observation of macroscopic quantum tunneling (MQT) in a single submicron Bi(2)Sr(2)CaCu(2)O(8+delta) surface intrinsic Josephson junction (IJJ) by measuring its temperature-dependent switching current distribution. All relevant junction parameters were determined in situ in the classical regime and were used to predict the behavior of the IJJ in the quantum regime via MQT theory. Experimental results agree quantitatively with the theoretical predictions, thus confirming the MQT picture. Furthermore, the data also indicate that the surface IJJ, where the current flows along the c axis of the crystal, has the conventional sinphi current-phase relationship.
A protocol for wide area secure networked appliance communication (2001)

This article describes problems associated with remotely accessing networked appliances (e.g., from the Internet). Networked appliances are widely viewed as the "next wave" of devices on the Internet. We discuss some possible uses for networked appliances and the requirements for communicating with them. We present details of a solution to meet these communication requirements based on the IETF Session Initiation Protocol. In addition, we discuss the rationale for our approach and reasons other approaches were not adopted. An example of the use of the SIP in this domain is presented to illustrate how the solution can be used. We conclude with outstanding challenges and reiterate advantages of this approach.
Inspection of complex surfaces by means of structured light patterns (2010)

This paper addresses the generalization of a surface inspection methodology developed within an industrial context for the characterization of specular cylindrical surfaces. The principle relies on the interpretation of a stripe pattern, obtained after projecting a structured light onto the surface to be inspected. The main objective of this paper is to apply this technique to a broader range of surface geometries and types, i.e. to free-form rough and free-form specular shapes. One major purpose of this paper is to propose a general free-form stripe image interpretation approach on the basis of a four step procedure: (i) comparison of different feature-based image content description techniques, (ii) determination of optimal feature sub-groups, (iii) fusion of the most appropriate ones, and (iv) selection of the optimal features. The first part of this paper is dedicated to the general problem statement with the definition of different image data sets that correspond to various types of free-form rough and specular shapes recorded with a structured illumination. The second part deals with the definition and optimization of the most appropriate pattern recognition process. It is shown that this approach leads to an increase in the classification rates of more than 2 % between the initial fused set and the selected one. Then, it is demonstrated that with approximately a fourth of the initial features, similar high classification rates of free-form surfaces can be obtained.
Downward continuation of moveout-corrected seismograms (1972)

Abstract Earlier work developed a method of migration of seismic data based on numerical solutions of partial differential equations. The method was designed for the geometry of a single source with a line of surface receivers. Here the method is extended to the geometry of stacked sections, or what is nearly the same thing, to the geometry where a source and receiver move together along the surface as in marine profiling. The basic idea simply stated is that the best receiver line for any reflector is just at (or above) the reflector. Data received at a surface line of receivers may be extrapolated by computer to data at a hypothetical receiver line at any depth. By considering migration before stacking over offset, it is found that certain ambiguities in velocity analysis may be avoided.