gebhart/patrepeval huggingface dataset:
Abstract 5881: Influence Of Cardiac Inflammation And Extracellular Matrix Regulation On Diastolic Dysfunction In Patients With Heart Failure With Normal Ejection Fraction (2008)

Aims: One of the hemodynamic mechanisms underlying heart failure with normal EF (HFNEF) is increased LV stiffness. In order to clarify the pathological changes leading to increased stiffness we investigated the left ventricular (LV) function using pressure-volume loops under basal conditions and during atrial pacing and investigated endomyocardial biopsies of patients with HFNEF. Methods: In 36 patients with HFNEF and 8 controls pressure volume loops were measured under basal conditions and during atrial pacing. Furthermore, endomyocardial biopsies were analyzed for changes in the extracellular matrix regulation, cardiac inflammation and changes in the titin isoforms. Results: Patients with HFNEF had an increased LV diastolic stiffness (+350%) compared to controls. During atrial pacing, stroke volume decreased (−35%) due to a leftward shift of the PV loops. This was associated with increased collagen content in cardiac biopsies (+380%), which blunted their cardiac output response to enhanced cardiac demand. This may explain the exercise intolerance in HFNEF patients. The total collagen correlated with cardiac stiffness in the HFNEF group (r2=0.69). This was associated with increased mRNA levels of the pro fibrotic TGF-b. Furthermore, the collagenase matrix metalloproteinases (MMP) 1 was not changed while TIMP-1 was increased (+150%), which supposes a decrease in collagen degradation in HFNEF. Nevertheless, MMP 2 was increased (+160%). This MMP is also associated with inflammation, and coherently, we investigated cardiac inflammation. We documented increased cardiac inflammation by an increment of adhesion molecules (ICAM +55%) and invading cells (CD11b cells +250%) in the cardiac tissue of HFNEF patients compared to controls. Interestingly, there was no change in titin isoforms between both groups. Conclusion: Patients with HFNEF have increased diastolic stiffness leading to an impairment of the Frank-Starling mechanism during atrial pacing. Since increased stiffness correlated with the cardiac collagen content, changes in the ECM regulation might be important for the development of HFNEF and invading cells triggering cardiac inflammation might further participate in this pathophysiology.
Towards JMS-Compliant Group Communication (2003)

Group communication provides communication primitives with various semantics and their use greatly simplifies the development of highly available services. However, despite tremendous advances in research and numerous prototypes, group communication stays confined to small niches and academic prototypes. In contrast, message-oriented middleware such as the Java Messaging Service (JMS) is widely used, and has become a de-facto standard. We believe that the lack of standard interfaces is the reason that hinders the deployment of group communication systems. Since JMS is well-established, an interesting solution is to map group communication primitives onto the JMS API. This requires to adapt the traditional specifications of group communication in order to take into account the features of JMS. The resulting group communication API, together with corresponding specifications, defines group communication primitives compatible with the JMS syntax and semantics.
Oligonol, a low‐molecular‐weight polyphenol derived from lychee peel, attenuates diabetes‐induced pancreatic damage by inhibiting inflammatory responses via oxidative stress‐dependent mitogen‐activated protein kinase/nuclear factor‐kappa B signaling (2018)

This study investigated the effects of oligonol, a low‐molecular‐polyphenol derived from lychee peel, against diabetes‐induced pancreatic damage via oxidative stress‐induced inflammation. Oligonol was orally administered at 10 or 20 mg/kg body weight/day for 10 days to streptozotocin‐induced diabetic rats, and the rats were compared with nondiabetic and diabetic control rats. The diabetic rats showed loss of body weight and increased pancreatic weight, and the oral administration of oligonol attenuated these parameters. Moreover, the administration of oligonol caused a significant decrease in the serum glucose level and a significant increase in the serum and pancreatic insulin and C‐peptide levels in the diabetic rats. Oligonol also significantly reduced the enhanced levels of reactive oxygen species and 2‐thiobarbituric acid reactive substance, which are oxidative stress biomarkers, in the serum and pancreas. Oligonol treatment reduced the overexpression of phospho‐p38, phospho‐ERK1/2, phospho‐inhibitor of nuclear factor‐kappa B (NF‐κB), NF‐κBp65, and NF‐κBp65‐induced inflammatory protein such as cyclooxygenase‐2, inducible nitric oxide synthase, tumor necrosis factor‐α, and interleukin‐6. Furthermore, oligonol treatment led to significantly attenuated histological damage in the pancreas. On the basis of these results, we conclude that a plausible mechanism of oligonol's antidiabetic action may be its antioxidative stress‐related anti‐inflammatory action.
Reactions of 5-(arylimino)-4-chloro-5H-1,2,3-dithiazoles with primary and secondary alkylamines: novel synthesis of (arylimino)cyanomethyl alkylamino disulfides and their mechanisms of formation (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of 5-(arylimino)-4-chloro-5H-1,2,3-dithiazoles with primary and secondary alkylamines: novel synthesis of (arylimino)cyanomethyl alkylamino disulfides and their mechanisms of formationHyunil Lee and Kyongtae KimCite this: J. Org. Chem. 1993, 58, 25, 7001–7008Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/jo00077a017https://doi.org/10.1021/jo00077a017research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An investigation of the Kishner elimination as a route to dideoxy sugars (1980)

Methyl 4,6-O-benzylidene-2-O-p-toluenesulphonyl-α-D-ribohexopyranosid-3-ulose has been used as a substrate for an investigation of the Kishner elimination as a route to deoxygenated sugars. The conditions of the reaction of the ketotosylate with hydrazine have a large effect on the outcome of the reaction and the products produced. Conditions have been investigated which provide methyl 4,6-O-benzylidene-α-D-erythrohex-2-enopyranoside (4), methyl 4,6-O-benzylidene-2,3-dideoxy-α-D-erythrohexopyranoside (3), methyl 4,6-O-benzylidene-3-deoxy-α-D-ribohexopyranoside (2), and methyl 4,6-O-benzylidene-2-deoxy-α-D-erythrohexopyranosid-3-ulose (8) in good to moderate yields.
ChemInform Abstract: POTENTIAL APPLICATION OF (1,3‐DITHIOL‐2‐YLIDENE)METAL COMPLEXES TO THE SYNTHESIS OF TETRATHIAFULVALENE DERIVATIVES (1985)

Abstract Die Dithioliumcarben‐Struktur des bei der Addition von Triphos‐Nihf‐CSZ) (I) an das Butin (II) gebildeten Liganden des diamagnetischen Ni‐Komplexes (III) stimmt mit der Spaltung von (III) durch überschüssiges (II) in den n‐Komplex (IV) und das entsprechende Dithioliumcarben [das sich zu dem Tetrathiafulvalen (V) dimerisiert] und ebenso mit der Bildung von (V) und (VI) bei der Verdrängung dieses Liganden durch CO überein.
Physiological Study of pH Stability and Sensitivity to Pepsin of Human Gastric Lipase (2002)

Although HGL is not as stable as it was previously thought to be under acidic conditions, it is nevertheless the most stable acid lipase and constitutes a good candidate tool for enzyme substitution therapy.
N‐Methylprolinol Catalysed Asymmetric Baylis−Hillman Reaction (2004)

Abstract N ‐methylprolinol is used as a chiral base catalyst for the Baylis–Hillman reaction to obtain the adducts in good yields with moderate to good enantioselectivities in 1,4‐dioxane:water (1 : 1, v/v) under ambient conditions.
Thermal anemometric assessment of coronary flow reserve with a pressure-sensing guide wire: An in vitro evaluation (2011)

Assessment of coronary flow reserve (CFR) with a commercially available pressure-sensor-tipped guide wire using the principle of thermal anemometry could provide major clinical benefits both in determining and in distinguishing between epicardial and microvascular coronary artery disease. In constant-temperature thermal anemometry, the electrical power required to maintain an element at a constant temperature is a measure for the local shear rate. Here, the feasibility of applying this thermoconvection method to a pressure-sensing guide wire is investigated using an in vitro model. A theoretical relation between electrical power and steady shear rate based on boundary layer theory was tested in an experimental set-up. In steady flow, a reproducible relation between electrical power and shear rate was obtained with an overheat temperature of 20 K, which was in good agreement with theory. The relation between shear rate and flow, however, depends on geometry of the artery and position of the guide wire inside the vessel. Although this means that this thermoconvection method is less useful for absolute flow measurements, CFR could be assessed even for unsteady flow using the steady calibration curve with a mean relative difference of (3 ± 5)% compared to CFR derived from the golden standard using an ultrasonic flow measurement device.
Microbubble-Enhanced Recovery of Residual Bitumen from the Tailings of Oil Sands Extraction in a Laboratory-Scale Pipeline (2020)

The recovery of valuables from industrial wastewater prior to release to the environment is indispensable to comply with ever pressing economic and environmental imperatives. In this work, microbubbles generated by a 3D-printed venturi tube were applied in a laboratory-scale pipeline loop to evaluate the recovery performance of residual bitumen from oil sands tailings. The addition of microbubbles provided a sufficient surface area in tailings media to capture effectively bitumen droplets. Our results showed that the injection of microbubbles upstream substantially enhanced the separation kinetics on account of providing sufficient time for the bitumen–bubble interaction prior to the collection trough. It was found that ca. 50% of residual bitumen can be recovered using the upstream injection of microbubbles for a duration of a 30 min circulation of tailings in the pipeline loop. Such enhancement in bitumen recovery revealed a high potency of microbubbles in collecting more bitumen from tailings in comparison with ca. 10% recovery achieved through flotation size bubbles injected by the needle. The findings of the current study suggest a new potential solution for intensification of the bitumen recovery process from industrial wastewater.
Adaptive control of a materials-testing machine (1996)

Testing is vital in the search for better materials, for quality control in manufacture, and for assurance about the life-time of components when subjected to cyclic loading. The adaptive control of servohydraulic materials testing machines is the subject of this paper. The machines described typically use sampling rates of 5kHz, have bandwidths of up to 500Hz, and control powers of many tens of kW. Standard servohydraulic systems can apply alternating loads at frequencies up to 300Hz superimposed on mean tensile or compressive loads. (4 pages)
Rationale for elective modified neck dissection (1988)

A retrospective study was conducted to give surgeons direction in deciding which type of modified neck dissection is proper elective treatment for the patient with a clinically negative neck. The medical records of 428 previously untreated patients (seen between January 1, 1970, and December 31, 1979) whose necks (i.e., NO) were electively dissected and who had had a primary squamous carcinoma of the oral cavity, oropharynx, larynx, or hypopharynx were included. The three major types of modified neck dissections studied were the supraomohyoid, the anterior, and the functional. Sixteen percent (70 of 428) of the patients had multiple positive nodes and 6% (28 of 428) had evidence of extracapsular invasion. A unilateral supraomohyoid dissection was most often used for primaries of the oral cavity. Bilateral anterior dissection was common for cancers of the larynx and hypopharynx, and functional neck dissection was equally distributed among the primary sites. None of the patients with primaries of the larynx or hypopharynx had pathologically positive nodes in the submental or submaxillary triangles. Advanced T-stage was generally associated with a greater incidence of subclinically positive nodes. Thirty percent of the patients received postoperative radiotherapy. The total number of nodes removed, the number of positive nodes with or without extracapsular invasion, and the anatomic location of the positive nodes were correlated with the type of dissection, the stage and site of the primary cancer, the use of postoperative radiotherapy, the regional (neck) failure, and survival.(ABSTRACT TRUNCATED AT 250 WORDS)
Flowable CVD Process Application for Gap Fill at Advanced Technology (2014)

In this work, we report the application of flowable chemical vapor deposition (FCVD) technology in sub-20nm devices and flash devices. FCVD displays a strong ability in filling the gap of not only high aspect ratio straight vertical trench, but also re-entrant narrow profile as well as small horizontal trench. Through optimizing the annealing conditions, the as-obtained FCVD film can fully satisfy both the STI and ILD requirements which have different thermal budget. The FCVD oxide film also shows a better WET resistance than HARP film does.
Mossbauer and magnetic susceptibility studies on the alloy series FeAl1-xCrx (1990)

Magnetic susceptibility measurements on the alloy series FeAl1-xCrx (0.05 or=0.35. The Mossbauer spectra illustrate the spread of electron density and hyperfine magnetic field at the iron sites. The onset of the ferromagnetic phase is explained in terms of the growth of nearest neighbour iron clusters and the critical concentration found for this alloy series 0.4<x<0.5 is compared with those observed for the analogous series FeAl1-xCux and FeAl1-xFex.
Lipoproteins and Diseases of the Brain (2017)

Apolipoprotein E4 (apoE4) and outer surface protein A (ospA) are pathogenic lipoproteins involved in the progression of Alzheimer’s disease and Lyme neuroborreliosis, respectively. Results from previous studies indicate that apoE4 exhibits neurotoxicity by activating amyloid beta pathways, and ospA causes damage to the brain by stimulating immune activity of microglia and astrocytes. These results, however, lack information about the specific interactions that develop between neurons and these two lipoproteins. It is essential to investigate the effect of these lipoproteins on neuronal morphology and function to better understand the mechanism of damage and disease of the brain. This chapter summarizes previous studies on the role of apoE4 and ospA in diseases of the brain and discusses experimental results from our own work that suggests new roles for apoE4 and ospA in neuronal outgrowth and synaptic loss.
Anomalous skin effect and collisionless power dissipation in inductively coupled discharges (2001)

International audience
Regulation of Multiple Basic Fibroblast Growth Factor Messenger Ribonucleic Acid Transcripts by Protein Kinase C Activators (1988)

The human astrocytoma cell line U87-MG expressed two major basic fibroblast growth factor (FGF) mRNA transcripts of 7.0 and 3.7 kilobase (kb), as well as several low abundance transcripts of lower mol wt (1.0–1.8 kb). The phorbol ester phorbol-12,13-dibutyrate caused a time- and dose-dependent increase in the abundance of basic FGF mRNA transcripts. At a concentration of 1 μM, phorbol ester increased the level of both the 7.0 and 3.7 kb transcripts within 4 h, reached a plateau at 1.5- to 2.5-fold above control levels by 6 h and remained elevated for at least 12 h. When measured at 6 h after drug addition, the abundance of both 7.0 and 3.7 kb transcripts was maximally stimulated by 100 nm phorbol ester (EC50 = 10–20 nm). FGF mRNA levels were also stimulated to a similar extent by platelet-derived growth factor (0.15–5 U/ml) or the synthetic diacycglycerol analog 1-oleoyl-2-acetyl-rac glycerol (1–300 nm) at doses which stimulated DNA synthesis in these cells. Neither (Bu)2cAMP (0.03–2 mm) nor A23187 (0.3–1000 nm) had any effect on FGF expression. When U87-MG cells were exposed to phorbol ester for 24 h several differences were observed: the dose response curve was shifted to the left (EC50 = 3–5 nm; maximum response at 10 nm phorbol ester) and the response of the 7.0 and 3.7 kb transcripts was attenuated at higher doses (100–1000 nm), perhaps reflecting down-regulation of protein kinase C by the phorbol ester. In addition, prolonged exposure to phorbol ester stimulated (2.8- to 3-fold) the expression of two low mol wt transcripts of approximately 1.5 and 1.8 kb in size. These data demonstrate that FGF mRNA expression is regulated by protein kinase C and provide evidence that multiple FGF mRNAs (perhaps resulting from alternative splicing) are capable of being transcribed under different conditions.
The Production of Inequalities within Families and Across Generations: The Intergenerational Effects of Birth Order and Family Size on Educational Attainment (2018)

There has long been interest in the extent to which effects of social stratification extend and persist across generations. We take a novel approach to this question by asking whether birth order and sibling group size in the parental generation influences the educational attainment of their children. To address this question we use Swedish population data on cohorts born 1960-1982. To study the effects of parental birth order and family size we apply a cousin fixed effects design and exploit information on twin births in the parents generation. Relative to having a first-born mother, having a second-born or fifth-born mother is associated with educational attainment at age 30 being 4% and 8% of a standard deviation lower, respectively. After adjusting for attained parental education and social class, the parental birth order effect is heavily attenuated. Nevertheless, we do find that children who share the same birth order and gender as their parents attain slightly more education, and this is particularly pronounced when the parents have higher levels of education themselves. We do not find clear or consistent evidence for parental sibling group size effects. Overall our results suggest that birth order and family size effects operate through a Markovian process of transmission.
Reconstruction of Soft Biological Tissues Using Laser Soldering Technology with Temperature Control and Biopolymer Nanocomposites (2022)

Laser soldering is a current biophotonic technique for the surgical recovery of the integrity of soft tissues. This technology involves the use of a device providing laser exposure to the cut edges of the wound with a solder applied. The proposed solder consisted of an aqueous dispersion of biopolymer albumin (25 wt.%), single-walled carbon nanotubes (0.1 wt.%) and exogenous indocyanine green chromophore (0.1 wt.%). Under laser exposure, the dispersion transforms into a nanocomposite due to the absorption of radiation and its conversion into heat. The nanocomposite is a frame structure of carbon nanotubes in a biopolymer matrix, which provides adhesion of the wound edges and the formation of a strong laser weld. A new laser device based on a diode laser (808 nm) has been developed to implement the method. The device has a temperature feedback system based on a bolometric infrared matrix sensor. The system determines the hottest area of the laser weld and adjusts the current supplied to the diode laser to maintain the preset laser heating temperature. The laser soldering technology made it possible to heal linear defects (cuts) in the skin of laboratory animals (rabbits) without the formation of a fibrotic scar compared to the control (suture material). The combined use of a biopolymer nanocomposite solder and a laser device made it possible to achieve a tensile strength of the laser welds of 4 ± 0.4 MPa. The results of the experiment demonstrated that the addition of single-walled carbon nanotubes to the solder composition leads to an increase in the ultimate tensile strength of the laser welds by 80%. The analysis of regenerative and morphological features in the early stages (1-3 days) after surgery revealed small wound gaps, a decrease in inflammation, the absence of microcirculatory disorders and an earlier epithelization of laser welds compared to the control. On the 10th day after the surgical operation, the laser weld was characterized by a thin cosmetic scar and a continuous epidermis covering the defect. An immunohistochemical analysis proved the absence of myofibroblasts in the area of the laser welds.
How coenzyme B12radicals are generated: methylmalonyl-CoA mutase at 2 Å resolution (1996)

able difference in the cobalt environment between the two states and that the conformation observed in the crystal structure is also representative for the aqueous solution.