gebhart/patrepeval huggingface dataset:
Minichromosomal maintenance proteins (MCM’s) as biomarkers for prostate cancer (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

3163 

Introduction: Prostate cancer is the most frequently occurring cancer in men accounting for 33% of cancer incidence and 10% of cancer deaths (American Cancer Society, 2004). Current diagnosis includes measurement of Prostate Specific Antigen (PSA) and digital rectal examination. These techniques provide valuable information, but are questionable with respect to sensitivity and specificity, especially since data reveals that PSA is not prostate specific and a variety of factors can alter its levels. This study aims to investigate MCMs (Mini-chromosomal maintenance proteins), as alternative markers of prostate disease. MCMs function in the ‘licensing’ of replication. Therefore, expression of these molecules is believed to increase in dysplastic and neoplastic cells. Recent work reveals that there is increased expression of MCM5 in the urine sediment of patients with bladder and prostate cancer, and that increased expression of MCM5 in tissue sections is predictive of bladder and colon cancer. Materials and Methods: Ethical approval was obtained from Northamptonshire Local Research Ethics Committee and informed consent was sought from patients undergoing investigation for prostate disease. Biopsy tissue was fixed in formalin and embedded in paraffin. Sections from 41 patients, representing the spectrum of benign and malignant disease, were examined following microwave antigen retrieval (0.01M sodium citrate buffer, pH 6.0) using immunohistochemistry with antibodies against MCM-2, -5 and -7 (Stratech, Cambridge UK). Results: This preliminary study reveals that MCM-2 and -7 proteins show little expression in non-involved or benign tissue, yet both are expressed in malignant tissue and appear to intensify as the grade and stage increases. MCM-5, like MCM-2 and -7, is hardly expressed in non-involved tissue but is expressed both in benign and malignant tissue, in which expression increases with both stage and grade. Although the localisation of staining is generally nuclear, in malignant cases cytoplasmic staining, which appears to increase with stage and grade, is also noted especially in the case of MCM-5. Discussion: There is an increasing body of evidence that MCM expression may be a valuable tool for assessing cancer. This study suggests that MCM -2, -5 and -7 are increasingly expressed correlating with the severity of prostate disease. Further analysis needs to be performed to conclude whether MCM proteins may contribute valuable information to current diagnostic strategy, and whether these molecules have potential for use in some type of non-invasive technique.
Suppression of microRNA-205-5p in human mesenchymal stem cells improves their therapeutic potential in treating diabetic foot disease (2017)

Diabetes is a prevalent disease endangering human health, while diabetic foot disease (DF) is one of the most severe complications of diabetes. Mesenchymal stem cells (MSCs) have been used in DF treatment, taking advantage of the differentiation potential of MSCs into endothelial cells and their production and secretion of trophic factors like vascular endothelial growth factor (VEGF). Molecular modification of MSCs to improve their therapeutic effects has been recently applied in treating other diseases, but not yet in DF. Here, we found that micoRNA-205-5p (miR-205-5p) is expressed in human MSCs, and miR-205-5p inhibits protein translation of VEGF through its interaction with 3'-UTR of the VEGF mRNA. Expression of antisense of miR-205-5p (as-miR-205-5p) significantly increased both cellular and secreted VEGF by MSCs, which significantly improved the therapeutic effects of MSCs on DF-associated wound healing in diabetic NOD/SCID mice. Together, our data suggest that miR-205-5p suppression in MSCs may improve their therapeutic effects on DF, seemingly through augmentation of VEGF-mediated vascularization.
STABILIZATION OF MARINE OILS WITH FLAVONOIDS (1998)

ABSTRACT Antioxidant activity of a number of flavonoids in refined‐bleached and deodorized (RBD) seal blubber oil (SBO) and menhaden oil (MHO) was compared with that of commercially used antioxidants, namely butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and tert‐butylhydroquinone (TBHQ) as well as α‐tocopherol. The study was carried under Schaal oven conditions at 65C and progression of oxidation was followed by monitoring weight gain, peroxide value (PV) and 2‐thiobarbituric acid reactive substances (TBARS) value. Among the flavonoids tested in this study, the flavonols, namely myricetin, quercetin and morin exhibited a stronger antioxidant activity than BHA and BHT and effectively stabilized both SBO and MHO. Myricetin was the most effective flavonoid tested in this study and its effect in reducing lipid oxidation was similar to that of TBHQ.
Effect of sulfolipid I on trehalose-6,6'-dimycolate (cord factor) toxicity and antitumor activity (1979)

Emulsified mixtures of sulfolipid I and trehalose-6,6'-dimycolate (cord factor) had tumor-regressive activity comparable to, but less toxic than, emulsified trehalose-6,6'-dimycolate alone.
Do total hip arthroplasty polyethylene liners without free radicals oxidize in vivo or ex vivo? (2021)

Crosslinking substantially reduces the wear of ultra-high molecular weight polyethylene (UHMWPE) used in total hip arthroplasty (THA) but some reports have indicated that first generation liners manufactured without antioxidants may be vulnerable to in vivo oxidation. This study evaluated maximum oxidation using Fourier transform infrared spectroscopy per ASTM F2102-06<sup>ε1</sup> and linear head penetration using a coordinate measuring machine among 66 revision-retrieved THA components with in vivo durations ranging from 0.02 to 24.6 years. These included 30 liners crosslinked with 5 Mrad of gamma radiation and then melted, 13 non-crosslinked, never-irradiated liners sterilized with gas plasma and 23 non-crosslinked, never-irradiated liners sterilized with ethylene oxide. All liners were vacuum-sealed and stored at -20°C prior to analysis with the exception of three retrievals of each material type that were stored in air for 9.9 to 21.5 years. All 57 vacuum-sealed and frozen retrievals demonstrated good oxidative stability with maximum oxidation indices (OIs) less than 1.0 and 75% (43/57) of these liners had maximum OIs less than 0.1. Linear penetration measurements were lower in the crosslinked liners compared to non-crosslinked retrievals. Although instances of oxidation and embrittlement were found after ex vivo storage in air among liners that did not have free radicals at the time of implantation, in vivo oxidation does not appear to be a clinical concern through the first decade of service for crosslinked liners and at up to 25 years after surgery for non-crosslinked liners.
Dynamical Birefringence: Electron-Hole Recollisions as Probes of Berry Curvature (2017)

Berry phase---a parameter that provides deep geometric insight into quantum mechanical systems---is difficult to measure in condensed-matter systems. New experiments and theoretical analyses demonstrate a path to such measurements by observing sidebands of infrared light transmitted through driven, thin layers of a semiconductor.
RFID and Finger Print Based Dual Security System: A Robust Secured Control to Access Through Door Lock Operation (2018)

This paper focuses on research works of control engineering field and aims at impenetrable security system especially in case of medication, jewelry, documents & others valuable items and mandatorily in the higher intelligence agency. Here, a developed security system with automatic sensing is introduced by the use of both Radio frequency identification (RFID) card tagging system and fingerprint sensing biometric security system to maintain the valid access of a person to a secured place. RFID reader and fingerprint sensing device work as a locker of the security and RFID tag and a validly ratified finger is considered as the key of the locker. In case of access granted entity, door bar gets opened with a servo mechanism system connected with door bar. On the contrary, no action is taken as cavalcade if the entity is considered invalid in the sensing system. These knock out the necessity for keeping track of keys or remembering a combination of password or pin. A prototype of the security system is also designed and the performance of it is tested. The satisfactory results of its performance show the validity of the system and indicate a better solution for the future security system.
Improving Delivery Ratio in LoRa Network (2021)

The LoRa (Long Range) radio communication provides large coverage areas, low bandwidth, small data rates, and transmitting limited data sizes, with very low energy usage. Multiple transmission channels are used, but the number of channels available is fairly limited - e.g. 8 in most countries in Europe. The amount of interferences may be estimated by the continuous observation of the number of delivered packets and the received signal strength. We propose to aggregate and analyse those metrics per channel and geographical area. When the proportion of received packets per some of the areas decreases, it is subjected to heavier interferences than other parts of the network and should be used less intensively. Thus we propose to allocate the weights for each channel per geographic area and/or device, defining the probability of the channel usage. Furthermore, we created an algorithm that periodically updates the weights and a simulation model using OMNeT++, FloRa, taking into account possible packets collisions. The algorithm has been validated for both random and realistic network topologies. The simulation evaluations show a significant improvement in the package delivery efficiency, by almost 50% in scenarios with very high interference level simulated and by more than 13% in scenarios fed with real-life measurements of packet delivery probability changes in time.
Surface Preparation Technique for Rapid Measurement of Sub-Surface Damage Depth (1990)

Most methods for fabrication of optical materials produce, in addition to the desired result (dimensional accuracy, surface figure, and surface roughness, etc.), the undesirable side effect of cracks or fractures in the material known as sub-surface damage. The "sub" prefix denotes the absence of clear evidence on the surface as to the existence of the damage below, particularly if the surface is subsequently polished. As a source of scattered light, figure instability, or in some cases, total failure of an optic, sub-surface damage can be detrimental in high precision optical systems. Detection and measurement of this sub-surface damage has become vital to the improvement of optical fabrication techniques. This paper describes the methods by which we detect and measure sub-surface damage (SSD).
The Effect of a Substitutional Solute Element on the Diffusivity of an Interstitial Solute Element in a Dilute Ternary Alloy (1978)

A model is developed to explain the dependence of the diffusion coefficient of an interstitial solute upon the concentration of substitutional solute. In the model, substitutional solute atoms act as traps for diffusing interstitial atoms and thus decrease the number of atomic jumps through the lattice of the solvent, but diffusion can also take place by jumps out of traps and within overlapping traps. Two parameters are used to develop the theory: the size of the trap around a substitutional atom, and the interstitial-substitutional solute binding energy. Three terms are shown to contribute to the magnitude of the interstitial diffusivity. The first term is for atomic jumps in the host lattice and from lattice into traps. The second is for jumps from traps to host lattice. The third is for jumps which occur entirely within traps. The theory predicts a marked initial decrease of the interstitial diffusion coefficient as a function of the substitutional concentration. After this initial decrease, the diffusivity goes through a minimum, and the position of this minimum depends upon the trap radius.
Target function approach to linear pursuit problems (1971)

The notion of target function is presented, and is applied to problems of pursuit with linear dynamics. It is shown that this approach unifies and extends the work of Pontryagin, Pshenichnyi, and many others. The approach is geometric in nature, and its application relies heavily on the geometric difference of convex sets and support functions of convex sets.
An evaluation of the immunity characteristics of an LSI with capacitors embedded in an interposer (2010)

To improve the electrical characteristics of LSIs, we are developing technology for embedding chip capacitors into interposers for LSIs. In this paper, we applied an interposer with embedded capacitors to an image-processing LSI and compared its electrical characteristics with that of a conventional LSI. We confirmed improvements in the timing margin, signal integrity, and immunity characteristics of the LSI.
Ultrafast Magnetism of a Ferrimagnet across the Spin-Flop Transition in High Magnetic Fields (2017)

We show that applying magnetic fields up to 30 T has a dramatic effect on the ultrafast spin dynamics in ferrimagnetic GdFeCo. Upon increasing the field beyond a critical value, the dynamics induced by a femtosecond laser excitation strongly increases in amplitude and slows down significantly. Such a change in spin response is explained by different dynamics of the Gd and FeCo magnetic sublattices following a spin-flop phase transition from a collinear to a noncollinear spin state.
Erratum: Novel optical approach to atomic force microscopy [Appl. Phys. Lett. 5 3, 1045 (1988)] (1988)

First Page
Subcutaneous Fat Reduction with Injected Ice Slurry (2020)

Physiological ice slurry injection is a promising new strategy for selective and nonsurgical fat removal.
Transfert de matière et électrocristallisation application à la galvanoplastie à haute densité de courant (1984)

SCOPUS: ar.j
Phylodynamics of SARS-CoV-2 transmission in Spain (2020)

Abstract Objectives SARS-CoV-2 whole-genome analysis has identified three large clades spreading worldwide, designated G, V and S. This study aims to analyze the diffusion of SARS-CoV-2 in Spain/Europe. Methods Maximum likelihood phylogenetic and Bayesian phylodynamic analyses have been performed to estimate the most probable temporal and geographic origin of different phylogenetic clusters and the diffusion pathways of SARS-CoV-2. Results Phylogenetic analyses of the first 28 SARS-CoV-2 whole genome sequences obtained from patients in Spain revealed that most of them are distributed in G and S clades (13 sequences in each) with the remaining two sequences branching in the V clade. Eleven of the Spanish viruses of the S clade and six of the G clade grouped in two different monophyletic clusters (S-Spain and G-Spain, respectively), with the S-Spain cluster also comprising 8 sequences from 6 other countries from Europe and the Americas. The most recent common ancestor (MRCA) of the SARS-CoV-2 pandemic was estimated in the city of Wuhan, China, around November 24, 2019, with a 95% highest posterior density (HPD) interval from October 30-December 17, 2019. The origin of S-Spain and G-Spain clusters were estimated in Spain around February 14 and 18, 2020, respectively, with a possible ancestry of S-Spain in Shanghai. Conclusions Multiple SARS-CoV-2 introductions have been detected in Spain and at least two resulted in the emergence of locally transmitted clusters, with further dissemination of one of them to at least 6 other countries. These results highlight the extraordinary potential of SARS-CoV-2 for rapid and widespread geographic dissemination.
Microwave opto-electronics in Europe (2003)

Recent European work on components, subsystems, and applications of microwave optoelectronics is reviewed, with particular emphasis on areas, such as coherent techniques and the use of optical amplifiers, which are likely to have a strong impact on new system design. Microwave optoelectronic components capable of operation well into the millimeter-wave region have been developed to commercial availability by a number of European manufacturers. Optical amplifiers seem likely to make microwave bandwidth networks with excellent signal to noise ratio a practical reality. Techniques for the generation of coherent optical signals have advanced substantially, so that it seems likely that coherent processing will become the preferred choice for optical beamforming in phase array antennas and many other signal processing applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Stress Relaxation of Tufted Carpets and Carpet Components (2002)

Dimensional stability of tufted carpets has been a continuing problem in the industry for years. When a tufted carpet is installed by the stretch method, it experiences stress relaxation over time which can cause the carpet to buckle, wrinkle and become loose with the only option being a costly re-stretching of the carpet. Since woven carpets seldom require re-stretching, the carpet buckling problem seems to be linked primarily to the tufted construction. This research seeks to analyze the various components of the tufted carpet composite structure and identify the role each component plays in the phenomenon of stress relaxation. Since a carpet is always stretched in both dimensions simultaneously during installation, understanding its biaxial stress decay is important. To this end, a biaxial loading system has been used to test various samples of the primary backing alone (before tufting), primary backing after tufting (with tufts), the secondary backing alone, and the finished carpet after attaching the backings with various binder weights per area. The four variables under consideration include: primary and secondary backing constructions, tufting density, and latex weight, with the secondary backing and latex weight expected to have the greatest effects on stress decay. In order to collect the most information, the biaxial test system was connected to a computer-based data acquisition system to continuously monitor stress levels and generate stress relaxation curves over a 20-hour testing period. A viscoelastic model that included representations of each component in the carpet structure was used to analyze and understand the influence of the components on the stress relaxation of carpets.
Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell (2010)

Lineage commitment and differentiation into mature cell types are mostly considered to be unidirectional and irreversible processes. However, recent results have challenged this by showing that terminally differentiated cell types can be reprogrammed into other cell types, an important step towards devising strategies for gene therapy and tissue regeneration. In this Review, we summarize recent data on the earliest steps in the development of the mammalian lymphatic vasculature: the specification of lymphatic endothelial cells (LECs). We elaborate on a developmental model that integrates the different steps leading to LEC differentiation and lymphatic network formation, discuss evidence that suggests that LEC fate is plastic, and consider the potentially far-reaching implications of the ability to convert one cell type into another.
The Patient with Bariatric Surgery (2012)

This chapter contains sections titled: Background Management options Acknowledgments References
Providing quality of service guarantees using only edge routers (2002)

Providing strict bandwidth guarantees to packet flows in the Internet is an inherently challenging task. It requires signaling mechanisms, policing mechanisms, accurate and rapid accounting of network resources and call admission control. We present a novel protocol that provides bandwidth guarantees to Internet packet flows. This protocol, called the edge-assisted quality of service (EQOS) protocol, requires modifications to only a subset of an administrative domain's routers, namely the edge routers on the domain's periphery. Legacy routers within the core of the domain require no modifications. Our protocol maintains a high network utilization by dynamic sharing of bandwidth between the reserved and best effort flows. We present the results of several simulation experiments showing that EQOS is able to provide bandwidth guarantees to competing flows.
C 13 – C 13 and N15–C13 correlation spectroscopy of membrane-associated and uniformly labeled human immunodeficiency virus and influenza fusion peptides: Amino acid-type assignments and evidence for multiple conformations (2008)

Many viruses which cause disease including human immunodeficiency virus (HIV) and influenza are "enveloped" by a membrane and infection of a host cell begins with joining or "fusion" of the viral and target cell membranes. Fusion is catalyzed by viral proteins in the viral membrane. For HIV and for the influenza virus, these fusion proteins contain an approximately 20-residue apolar "fusion peptide" that binds to target cell membranes and plays a critical role in fusion. For this study, the HIV fusion peptide (HFP) and influenza virus fusion peptide (IFP) were chemically synthesized with uniform (13)C, (15)N labeling over large contiguous regions of amino acids. Two-dimensional (13)C-(13)C and (15)N-(13)C spectra were obtained for the membrane-bound fusion peptides and an amino acid-type (13)C assignment was obtained for the labeled residues in HFP and IFP. The membrane used for the HFP sample had a lipid headgroup and cholesterol composition comparable to that of host cells of the virus, and the (13)C chemical shifts were more consistent with beta strand conformation than with helical conformation. The membrane used for the IFP sample did not contain cholesterol, and the chemical shifts of the dominant peaks were more consistent with helical conformation than with beta strand conformation. There were additional peaks in the IFP spectrum whose shifts were not consistent with helical conformation. An unambiguous (13)C and (15)N assignment was obtained in an HFP sample with more selective labeling, and two shifts were identified for the Leu-9 CO, Gly-10 N, and Gly-10 Calpha nuclei. These sets of two shifts may indicate two beta strand registries such as parallel and antiparallel. Although most spectra were obtained on a 9.4 T instrument, one (13)C-(13)C correlation spectrum was obtained on a 16.4 T instrument and was better resolved than the comparable 9.4 T spectrum. More selective labeling and higher field may, therefore, be approaches to obtaining unambiguous assignments for membrane-associated fusion peptides.
Hepatitis C virus eradication decreases the risks of liver cirrhosis and cirrhosis‐related complications (Taiwanese chronic hepatitis C cohort) (2021)

Hepatitis C virus eradication with PR therapy decreased the incidence of new-onset LC in noncirrhotic patients and the incidence of liver-related complications in cirrhotic patients with CHC.