gebhart/patrepeval huggingface dataset:
Electron microscopic study of lymphatic tissues of mice inoculated with a leukemogenic extract from radiation-induced tumors. (1973)

Summary Macroscopic, histological, and ultrastructural changes in lymphatic tissues, particularly that of the spleen, were studied in C57BL mice inoculated i.p. with a cell-free extract (Passage D from Dr. Duplan) of lymphatic tissues from mice in which leukemia was originally radiation induced. Splenomegaly was observed macroscopically, followed by hypertrophy of lymph nodes. But no change of the thymus was apparent throughout the course of this infection. The histological appearance of the spleen showed hyperplasia of the germinal centers within the lymphatic nodules. The lymphoid cells were replaced progressively by proliferation of the reticular cells and, to a lesser extent, by cells of the plasmocytic line. Typical type C particles were found in the splenic white pulp. During the early stages of this disease, the particles were concentrated in the extracellular spaces within the germinal centers. The infected cells were predominantly immunoblasts, plasmoblasts, plasmocytes, and to a lesser extent lymphoblasts, lymphocytes, and reticular cells. Viral particles could not be detected within megakaryocytes or erythrocytic precursor cells. A few intracisternal type A particles were observed in both plasmocytes and reticular cells. The characteristics of this leukemia are discussed in relation to those described by Kaplan and Rauscher.
Kinetics of Trichloroethene Reduction by Zerovalent Iron and Tin:  Pretreatment Effect, Apparent Activation Energy, and Intermediate Products (1998)

The degradation of trichloroethene (TCE) at 2 mg L-1 in headspace free aqueous solution by zerovalent iron (Fe0) and tin (Sn0) was studied in batch tests at 10, 25, 40, and 55 °C and HCl-treated Fe0 and Sn0 at 25 and 55 °C. Surface area normalized pseudo-first-order rate constants (kSA) ranged from 0.44 × 10-3 to 4.3 × 10-3 h-1 m-2 L for Fisher Fe0, 0.029 × 10-3 to 0.27 × 10-3 h-1 m-2 L for Peerless and Master Builders Fe0, and 0.011 × 10-3 to 1.31 × 10-3 h-1 m-2 L for Fisher and Aldrich Sn0. The Aldrich Fe0 was the least reactive with kSA values ranging from 0.0016 × 10-3 to 0.011 × 10-3 h-1 m-2 L. The HCl-washing increased metal surface area and observed rate constant (k) values but generally decreased kSAvalues. The calculated apparent activation energy (Ea) using the Arrhenius law for the four temperature levels ranged from 32.2 to 39.4 kJ mol-1 for the untreated Fe0 metals and 40.5−76.8 kJ mol-1 for the untreated Sn0 metals. Greater temperature effect was observed for Sn0 than for Fe0. Our results indicate that TCE reduction by Fe0 and Sn0 is likely controlled primarily by chemical reaction-limited kinetics rather than by mass transport of the TCE to the metal surface. Both reductive β-elimination reaction and hydrogenolysis reaction are likely involved in the reduction of TCE by both Fe0 and Sn0.
IMMU-35. INDUCTION OF ANTI-TUMOR IMMUNITY BY TUMOR TREATING FIELDS (TTFIELDS) IN GLIOBLASTOMA (2021)

Abstract INTRODUCTION The novel approved GBM treatment TTFields employs alternating, intermediate-frequency (200kHz) electric fields to disrupt mitotic macromolecules leading to chromosome mis-segregation and apoptosis. Emerging evidence indicates that TTFields may also induce inflammation; however, the mechanism and whether this can be harnessed as cancer immunotherapy remain unclear. METHODS Multiple GBM cell lines were treated with TTFields using Inovitro, an in vitro TTFields system and integrity of the nuclear envelope and content and activation of key DNA sensor inflammatory pathways analyzed by immunostaining, expression profiling, and protein assays. In a syngeneic orthotopic murine model, TTFields-treated GBM cells were used to provide an in-situ vaccination platform. For validation, we performed bulk and single-cell RNAseq of PBMCs from 12 newly diagnosed GBM patients treated with TTFields. RESULTS TTFields induce focal disruption of the nuclear envelope, leading to cytosolic release of large micronuclei clusters that recruit and intensely activate the 2 major DNA sensors – cGAS and AIM2, and their cognate inflammasomes, thereby releasing pro-inflammatory cytokines and type-1 interferons (T1IFNs) that promote development and maturation of DCs and cytotoxic T cells. In murine model, TTFields-treated GBM cells induce anti-tumor memory immunity both intratumorally and systemically, producing a cure rate of 40% and partial immunity in an additional 25% in a STING- and AIM2-dependent manner. In patients with newly diagnosed GBM patients, we sequenced a total of 193,760 PBMCs and detected robust post-TTFields activation of adaptive immunity via the T1IFN trajectory anchored by plasmacytoid DCs, which was strongly correlated with the TCRαβ clonal expansion index observed in 11 of 12 patients (Spearman coefficient r=-0.8, P=0.014). Importantly, we also defined a T cell-based gene signature predictive of TTFields effects on T cell activation and TCRαβ clonal expansion. CONCLUSION Collectively, these studies define a novel strategy using TTFields to improve immunotherapy in GBM and potentially other solid tumors.
3ds Max 8 Essentials (2014)

Welcome to the Autodesk Media and Entertainment Official Training Courseware for 3ds Max 8 software! Consider this book an all-access pass to the production and training experience of Autodesk developers and training experts. Written for self-paced learning or instructor-led classroom training, the manual will teach you the fundamentals of using 3ds Max 8. The book is organized into sections dedicated to animation, modelling, materials, lighting and rendering. Each section covers basic theory, and then includes exercises for hands-on demonstration of the concept. By the end of the book, you will have mastered the basics and moved onto full-length projects. Flexibility is built in, so that you can complete the tutorials in the way that works best for you. Complete the book and you will be a seasoned 3ds Max pro, ready to work confidently in a production environment.
Katriel's operations for products of conjugacy classes of Sn (2005)

International audience
Implementation of nearest-neighbor searching in an online chemical structure search system (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImplementation of nearest-neighbor searching in an online chemical structure search systemPeter Willett, Vivienne Winterman, and David BawdenCite this: J. Chem. Inf. Comput. Sci. 1986, 26, 1, 36–41Publication Date (Print):February 1, 1986Publication History Published online1 May 2002Published inissue 1 February 1986https://pubs.acs.org/doi/10.1021/ci00049a008https://doi.org/10.1021/ci00049a008research-articleACS PublicationsRequest reuse permissionsArticle Views313Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A novel handover scheme for seamless wireless connectivity in high-speed rail (2011)

It is a great challenge to design an efficient handover scheme of broadband wireless communication systems for high-speed rail to reduce the communication interruption time during handover. A seamless handover scheme based on the dual-layer and dual-link system architecture is proposed in this paper. In the scheme, two antennas are mounted at the front and rear of a train, and one of them executes handover while the other is still communicating with BS. Therefore, the communication will not be interrupted throughout the handover. Furthermore, bi-casting is adopted to eliminate the data forwarding delay between the serving BS and target BS. In order to reduce handover implementation overhead, a Train Relay Station is employed to represent all the users in a train to execute handover in the proposed scheme. The performance of the proposed scheme is analyzed in terms of handover probability, handover failure probability and communication interruption probability. Simulation and theoretical results show that the proposed scheme can efficiently support seamless handover for high-speed trains with low implementation overhead.
A Novel GDP-Mannose Mannosyl Hydrolase Shares Homology with the MutT Family of Enzymes (1995)

The product of the Escherichia coli orf1.9, or yefc, gene (GenBank accession number L11721) has been expressed under the control of a T7 promoter, purified to apparent homogeneity, and identified as a novel enzyme that hydrolyzes GDP-mannose or GDP-glucose to GDP and the respective hexose. The enzyme has little or no activity on other nucleotides, dinucleotides, nucleotide sugars, or sugar phosphates. It has a pH optimum between 9.0 and 9.5, a Km of 0.3 mM, and a Vmax of 1.6 mumol min-1 mg-1 for GDP-mannose, and it requires divalent cations for activity. This enzyme of 160 amino acids (M(r) = 18, 405) contains the consensus sequence GX(I/L/V)(E/Q)(X)2ET(X)6R(X)4E(X)2(I/L), characteristic of the MutT family of proteins and previously shown to form part of the nucleotide-binding site of MutT (Frick, D. N., Weber, D. J., Abeygunawardana, C., Gittis, A. G., Bessman, M. J., and Mildvan, A. S. (1995) Biochemistry 34, 5577-5586). A comparison of the enzymatic reactions catalyzed by the GDP-mannose mannosyl hydrolase and the other enzymes of the MutT family suggests that the consensus signature sequence designates a novel nucleoside diphosphate binding site and catalytic motif.
Comparison of Four Digitizers for Time-Domain EPR (2000)

Pulsed, time-domain electron paramagnetic resonance (EPR) requires fast data collection. The ideal is for the data acquisition rate to be limited by the spin relaxation times, and not by the data collection hardware and software. Four devices with fast time response were compared in the collection of pulsed EPR data. The fastest data collection was achieved with a Bruker E587 SpecJet transient signal averager.
Beneath the Surface (2010)

Surface computing is about integrating the physical world and the virtual world through the use of vision‐based touch. While Microsoft's Surface product is the best‐known implementation of surface computing, it is far from the only one. Expanding university research on touch continues to make use of vision‐based touch as a foundation, which in turn will help move surface computing toward full commercialization.
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates (2005)

Knowledge of the molecular networks controlling the proliferation and fate of hematopoietic stem cells (HSC) is essential to understand their function in maintaining blood cell production during normal hematopoiesis and upon clinical transplantation. Using highly purified stem and progenitor cell populations, we define the proliferation index and status of the cell cycle machinery at discrete stages of hematopoietic differentiation and during cytokine-mediated HSC mobilization. We identify distinct sets of cell cycle proteins that specifically associate with differentiation, self-renewal, and maintenance of quiescence in HSC and progenitor cells. Moreover, we describe a striking inequality of function among in vivo cycling and quiescent HSC by demonstrating that their long-term engraftment potential resides predominantly in the G(0) fraction. These data provide a direct link between HSC proliferation and function and identify discrete molecular targets in regulating HSC cell fate decisions that could have implications for both the therapeutic use of HSC and the understanding of leukemic transformation.
Prospective Study of Occupation and Amyotrophic Lateral Sclerosis Mortality (2005)

Occupational exposures are suspected of contributing to the risk of amyotrophic lateral sclerosis (ALS), but results of epidemiologic studies have been inconsistent. The authors prospectively assessed the relation between occupation and ALS mortality among more than 1 million participants in the Cancer Prevention Study II of the American Cancer Society. Follow-up from 1989 through 2002 identified 507 ALS deaths among men and 430 among women. Adjusted rate ratios were calculated by using Mantel-Haenszel weights and Cox proportional hazards. Among men, elevated ALS mortality was found for programmers (rate ratio = 4.55, 95% confidence interval: 1.46, 14.2; p = 0.009) and laboratory technicians (rate ratio = 1.96, 95% confidence interval: 1.04, 3.66; p = 0.04). Occupations previously associated with increased risk of ALS for which no increased risk was found included farmers, electricians, and welders, although the numbers of electricians (eight ALS deaths) and welders (two ALS deaths) were small. Among women, only machine assemblers had significantly increased ALS mortality (rate ratio = 2.81, 95% confidence interval: 1.05, 7.53; p = 0.04). Results, which suggest that male programmers and laboratory technicians and female machine assemblers may be at increased risk of death from ALS, should be interpreted cautiously, however, because they are based on small numbers.
An Improved Adversarial Example Generating Method With Optimized Spatial Transfrom (2020)

Deep learning model has good performance in image classification, target detection, face recognition and other tasks, but it is prone to misjudgment in the face of adversarial attack. Research on adversarial sample generation method can improve the security of deep learning model. Compared with the algorithm based on spatial transform, the existing generation methods of adversarial samples based on pixel value perturbation of the original image can effectively reduce the construction time of the adversarial samples, but the generated adversarial samples are significantly different from the original image in perception, which can be easily find by human eyes. The method proposed in this paper aims to reduce the attack time and ensure the similarity of visual perception and attack success rate between the adversarial sample and the original image. The simulation results show that compared with traditional adversarial sample generation method based on spatial transform, this method can reduce time about 30%, at the same time, this method can effectively guarantee the human eye observation under the adversarial samples and the similarity of the original image.
Outcome of Primary Pterygium Surgery Using the Inferior Conjunctival Autograft (2020)

INTRODUCTION &#x0D; Pterygium is a common ocular condition with prevalence varying from 0.7-39% in different population and particularly high in the tropics. Various surgical techniques including inferior conjunctival autograft are available for the treatment of pterygium. This study was done to determine the clinical profile and outcome of primary pterygium surgery using inferior conjunctival autograft.&#x0D; MATERIAL AND METHODS &#x0D; This was a prospective, non-comparative interventional study conducted over a period of one year from January to December 2019 in patients with primary pterygium who presented at cornea department of Lumbini Eye Institute and Research Center, Bhairahawa, Nepal. All the patients with primary pterygium, a detail clinical history and examination were done. Pterygium was excised using inferior conjunctival autografting and followed regularly over a period of 3 months.&#x0D; RESULTS &#x0D; We analysed 626 eyes in 619 patients with primary pterygium in which mean age was 44.63 ± 13.84 years. There were 363 (58.64%) females. Majority of our patients were housewife 350 (56.54%) and farmer 170 (27.46%). Mean duration of presentation was 3.59 ± 2.87 year. Pterygium was found mostly on nasal side 614 (98.08%). Depending on the size, maximum patients had type 2 pterygium (73.80%) followed by type 3 pterygium (18.69%). The commonest post operative complication was raised intraocular pressure which was seen in 43 (6.87%) eyes and recurrence rate was 0.64%.&#x0D; CONCLUSION &#x0D; Primary pterygium was seen more commonly in adults in their 4th -5th decade of life with female predominance. Primary pterygium surgery using inferior conjunctival autograft is a safe and effective with very few complication and recurrence.&#x0D;
Combined steel melt filtration through reactive and active filters (2023)

A combined filtration system was investigated for the first time in the present work. A reactive filter was immersed in a steel melt containing artificially generated endogenous inclusions. After extracting the filter, the melt was poured through a second filter and into a crucible where it cooled down. The second filter had a pure aluminum oxide flame-sprayed coating, in order to prevent reactions and only remove pre-existing inclusions. It was observed that the immersion of a reactive, coated filter generally resulted in larger inclusions. When no casting was performed, or when the second filter was omitted, smaller remaining inclusions were found. Calcium aluminate based coatings resulted in the creation of new multiphase inclusions (and less alumina). Although these results cannot be directly compared with state-of-the-art industrial filtration procedures, active filtration seems so far the most promising approach to produce steel of improved quality. In addition, filters with a calcium aluminate-based coating might be interesting in the production of steel with tailored inclusions for special applications.
Actin-Binding Specificity of Marine Macrolide Toxins, Mycalolide B and Kabiramide D (1998)

An actin-depolymerizing marine natural product, mycalolide B, and a related compound, kabiramide D, were labeled with biocytin, a biotin derivative, and used to specify target molecules in cultured rat 3Y1 fibroblasts. Mycalolide B exhibited the ability to bind to various intracellular proteins, probably through the Michael addition of a sulfhydryl group to C5 of mycalolide B. However, no intracellular proteins other than actin apparently reacted with biocytinylated kabiramide D, demonstrating that the binding of kabiramide D to actin was highly specific. Cells treated with biocytinylated kabiramide D followed by staining with fluorescein isothiocyanate-conjugated avidin showed that biocytinylated kabiramide D bound to stress fibers composed of F-actin, although the staining intensity was weaker than the fluorescent phalloidin staining. The assay for the binding of kabiramide D to actin, which had previously been treated with other actin-depolymerizing agents, showed that the actin-binding site for kabiramide D was the same as that for bistheonellide A, but not those for latrunculin A and cytochalasin D.
PDGF B mRNA variants in human tumors with similarity to the v-sis oncogene: Expression of cellular PDGF B protein is associated with exon 1 divergence, but not with a 3'UTR splice variant (2000)

While platelet-derived growth factor, PDGF, is not regularly expressed in mesenchymal tissues, PDGF B mRNA is often found in tumors derived from these tissues. PDGF B protein is also present, but the protein levels in individual tumors do not appear to correlate well with those of the mRNA. PDGF B is homologous to the v-sis oncogene of simian sarcoma virus (SSV), and certain deletions confined to 3; and 5; non-coding sequences of PDGF B mRNA are consistently found in tumors induced by SSV and by a PDGF B retrovirus. Part of exon 1, including a non-coding GC-rich regulatory domain and the signal sequence as well as a 149 nucleotide long AU-rich stretch in the 3; non-coding region, are often lost. We hoped that this information could provide a clue to defective regulatory mechanisms present in human tumors and have searched for such mRNA variants in human sarcoma cell lines and soft tissue tumors. We identified a splice variant of PDGF B mRNA that, similar to v-sis, lacks the 149 nucleotide stretch and introduces an anomalous splice point between exons 6 and 7. This weakly abundant mRNA variant was co-expressed with the regular PDGF B mRNA, but its presence failed to show any association with increased levels of immunohistochemically detectable PDGF B protein. Instead, the highest levels of cellular PDGF B protein were found in samples with mRNAs showing exon 1 divergence. The changes in the 5; end of the mRNA were not accompanied by any genomic aberrations.
Oxygen Nonstoichiometry of Perovskite-type La0.6Sr0.4Co1-yFeyO3-δ (y=0, 0.2, 0.4, 0.5, 0.6, 0.8, 1) SOFC Cathode Materials (2011)

The oxygen nonstoichiometry of La 0.6 Sr 0.4 Co 1-y Fe y O 3-δ (LSCF) mixed-conducting perovskite-oxides can be classified into two groups: the cobalt-rich compounds (y=0, 0.2, 0.4) were previously reported to show a sharp decrease in oxygen content with reducing atmosphere, while the oxygen vacancy concentration increased more smoothly for the iron-rich compounds (y=0.6, 0.8, 1). Here we measured the oxygen content of LSCF with y=0.5 by thermogravimetry and coulometric titration as a function of oxygen partial pressure and temperature. No transitional behavior could be observed for La 0.6 Sr 0.4 Co 0.5 Fe 0.5 O 3-δ , the oxygen nonstoichiometry showed the same behavior as for the cobalt-rich compounds. Except for y=1, the thermo-chemical stability of LSCF was little affected by the iron dopant content, all compounds (y=0-0.8) decomposed at similar oxygen partial pressures.
On-wafer small-signal and large-signal measurements up to sub-THz frequencies (2014)

Recent advances in MMIC technology have opened the possibilities for circuit operation in the THz range. There are numerous examples of BiCMOS and III-V compound device technologies with demonstrated performance beyond 600 GHz. Characterization of such MMIC are predominantly performed on-wafer in a planar environment. However, on-wafer characterization facilities do not fully keep pace with MMIC development in terms of frequency and power. The paper discusses issues involved in on-wafer calibration at mm-wave frequencies, which is the basis for accurate measurements and characterization of active and passive device. Subsequently, the paper discusses mm-wave interconnect characterization. Low-loss interconnects are important for mm-wave MMIC, especially in case of heterogeneous integration. Finally, a novel heterogeneous integration approach of bipolar technologies, using both BiCMOS and InP DHBT processes is presented. This approach heavily relies on low-loss interconnects and accurate device modelling. It will be shown that accurate large-signal models can be efficiently extracted from well-calibrated on-wafer multi-bias small-signal measurements, but verification is difficult due to calibration difficulties at mm-wave frequencies.
Ceramic Heads Decrease Metal Release Caused by Head-taper Fretting and Corrosion (2016)

We found that ceramic femoral heads may be an effective means by which to reduce metal release caused by taper fretting and corrosion at the head bore-stem cone modular interface in THAs.