gebhart/patrepeval huggingface dataset:
Solution structures of 6,7-dimethyl-8-substituted-lumazines. Carbon-13 NMR evidence for intramolecular ether formation (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution structures of 6,7-dimethyl-8-substituted-lumazines. Carbon-13 NMR evidence for intramolecular ether formationDavid H. Bown, Paul J. Keller, Heinz G. Floss, Helmut Sedlmaier, and Adelbert BacherCite this: J. Org. Chem. 1986, 51, 13, 2461–2467Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/jo00363a011https://doi.org/10.1021/jo00363a011research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Machine Learning to Predict Developmental Neurotoxicity with High-Throughput Data from 2D Bio-Engineered Tissues (2019)

There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as <b><i>in vivo</i></b> animal studies, and assays of animal and human primary cell cultures, suffer from challenges related to time, cost, and applicability to human physiology. Prior work has demonstrated success employing machine learning to predict developmental neurotoxicity using gene expression data collected from human 3D tissue models exposed to various compounds. The 3D model is biologically similar to developing neural structures, but its complexity necessitates extensive expertise and effort to employ. By instead focusing solely on constructing an assay of developmental neurotoxicity, we propose that a simpler 2D tissue model may prove sufficient. We thus compare the accuracy of predictive models trained on data from a 2D tissue model with those trained on data from a 3D tissue model, and find the 2D model to be substantially more accurate. Furthermore, we find the 2D model to be more robust under stringent gene set selection, whereas the 3D model suffers substantial accuracy degradation. While both approaches have advantages and disadvantages, we propose that our described 2D approach could be a valuable tool for decision makers when prioritizing neurotoxicity screening.
Grey swan tropical cyclones (2015)

Abstract We define ‘grey swan’ tropical cyclones as high-impact storms that would not be predicted based on history but may be foreseeable using physical knowledge together with historical data. Here we apply a climatological–hydrodynamic method to estimate grey swan tropical cyclone storm surge threat for three highly vulnerable coastal regions. We identify a potentially large risk in the Persian Gulf, where tropical cyclones have never been recorded, and larger-than-expected threats in Cairns, Australia, and Tampa, Florida. Grey swan tropical cyclones striking Tampa, Cairns and Dubai can generate storm surges of about 6 m, 5.7 m and 4 m, respectively, with estimated annual exceedance probabilities of about 1/10, 000. With climate change, these probabilities can increase significantly over the twenty-first century (to 1/3, 100–1/1, 100 in the middle and 1/2, 500–1/700 towards the end of the century for Tampa). Worse grey swan tropical cyclones, inducing surges exceeding 11 m in Tampa and 7 m in Dubai, are also revealed with non-negligible probabilities, especially towards the end of the century.
Surface modeling and parameterization with manifolds (2005)

Article Surface modeling and parameterization with manifolds Share on Authors: Cindy Grimm Washington University in St. Louis Washington University in St. LouisView Profile , Denis Zorin New York University New York UniversityView Profile Authors Info & Claims SIGGRAPH '05: ACM SIGGRAPH 2005 CoursesJuly 2005 Pages 1–eshttps://doi.org/10.1145/1198555.1198688Online:31 July 2005Publication History 1citation603DownloadsMetricsTotal Citations1Total Downloads603Last 12 Months6Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Clinical Features and Outcome of 415 Female Lung Cancers. (1996)

1965年より1994年まで当科において手術を施行した女性肺癌患者415例 (26.8%) を対象とし臨床病理学的に男性肺癌被手術群と比較検討した.女性肺癌患者は増加傾向にあり, 男性と比べ, 若年層に多く, 腺癌, 末梢発生, 集検発見が多く, 腫瘍径は小であった.女性肺癌被手術群の5生率は58.0%であり, 男性のそれに比べ有意に良好であった.組織別根治度を検討するに腺癌根治群のみ男性に比し有意に5生率が良好であり, 腺癌非根治群, 扁平上皮癌では有意差はなかった.女性肺癌患者の予後が良好な原因は, 末梢発生で腺癌が多く集検発見が多いので, 早期発見が容易なためと思われた.喫煙習慣で重喫煙者に扁平上皮癌の比率が高く, 喫煙者数, 扁平上皮癌数は共に増加していたが, 全体に占める割合は低下しており, 喫煙が女性肺癌に及ぼす影響は男性と同様に扁平上皮癌の増加には関係しているが, 女性肺癌を増加させる直接の原因とは考えにくいと思われた.
Ammonia Synthesis Activity of Alumina-Supported Ruthenium Catalyst Enhanced by Alumina Phase Transformation (2019)

The increase of alumina calcination temperature from 800 °C to 1300 °C results in the transformation of γ-Al2O3 to α-Al2O3 phase accompanying a decrease of specific surface area and the amount of tetrahedral Al3+ sites. Over Ru–Ba/alumina catalysts, an increase in alumina calcination temperature would broaden the size distribution of Ru particles, enlarge the metal-to-oxide ratio of Ru, decrease the amount of surface hydroxyl groups, as well as lower the temperature for N2 desorption. As a result, the increase of alumina calcination temperature lessens the effect of hydrogen poisoning and decreases the activation energy for ammonia synthesis. The Ru–Ba/Al2O3 catalyst with alumina calcined at 980 °C having both θ-Al2O3 and α-Al2O3 shows ammonia synthesis rate three times higher than that with alumina calcined at 800 °C having a γ-Al2O3 phase.
Bacterial Flora of the Hemolymph of the Blue Crab, Callinectes sapidus: Most Probable Numbers (1975)

The hemolymph of 290 freshly collected blue crabs from Chincoteague Bay, Va., was sampled over a 15-month period from August 1968 through November 1969 and most probable numbers of bacteria were determined by tube dilution. The hemolymph of 18% of all crabs sampled was found to be sterile, with 16% sterility in summer and 23% in winter samples. Despite individual variations, male crabs as a group had a higher bacterial hemolymph burden than females, and among both sexes summer counts were higher than winter. The hemolymph of crabs with missing appendages had significantly higher counts than uninjured crabs. The annual mean hemolymph most probable numbers per ml was 2,756 for males, 1,300 for females, and 1,876 for both sexes. The higher bacterial levels found in the hemolymph of male crabs may, in part, be explained by the fact that males, which predominated in the summer samples, had a higher incidence of injury and missing appendages than did females.
Stable Capsaicinoid Biosynthesis during the Fruit Development Stage of <i>Capsicum baccatum</i> (2019)

Capsaicin and its analogs, which are collectively called capsaicinoids, are pungent components that are produced only in Capsicum species. Several reports have indicated that chili peppers start accumulating capsaicinoids in fruits approximately 20 days after flowering (DAF), with capsaicinoid levels continuing to increase until 40 DAF and then decreasing. In this study, a Capsicum baccatum cultivar was analyzed to investigate capsaicinoid accumulation and the morphological changes to capsaicinoid-producing cells in maturing fruits. Capsaicinoids accumulated and capsaicinoid-producing cells were detected at 10 DAF. Additionally, the capsaicinoid contents increased during the fruit development stage. At 40 DAF, the nuclear shape was unclear, and cytoplasm appears to condense in C. baccatum.
Performance analysis of medium voltage series connected 12-pulse current source controlled rectifier using static VAR compensator (2008)

The performance analysis of a medium voltage series connected 12-pulse current source controlled rectifier by using static VAR compensator is presented. A new p-q locus is used where the maximum reactive power absorbed by the converter is halved and provides minimum input current total harmonic distortion (THD). Simulation and discussion are introduced when two static VAR Compensators (SVCpsilas) are connected to the secondary side of the front end phase shifting transformer. The results are compared with no compensation added to the system.
Antenne SIW à fente en anneau carré basé sur structure à ondes lentes (2017)

National audience
Interaction of a trypsin-like enzyme of Porphyromonas gingivalis W83 with antithrombin III (1993)

We have previously observed that trypsin-like activity in Porphyromonas gingivalis culture supernatants is inhibitable by the plasma arg-serpin antithrombin III (ATIII). This report demonstrates that a partially purified P. gingivalis trypsin-like enzyme (Mr 47 000) is inhibited by ATIII with an association rate constant (kass) of 5.65 × 104 M−1 s−1 but does not form SDS-stable complexes. Heparin enhances the kass and stabilizes the complexes but in either case such inhibition is temporary and results in ATIII inactivation by reactive centre proteolysis between R393-S394. In the absence of heparin this is accompanied by N-terminal cleavage between K39-I40.
Properties of Composite Electrodes for All-solid-state Fluoride-ion Secondary Batteries Processed by High-pressure Torsion (2023)

All-solid-state fluoride-ion batteries (FIBs) using metal/metal fluorides are expected to be the next generation of storage batteries because they exhibit high volumetric energy densities by utilizing multielectron reactions, compared to the current lithium-ion batteries. However, method of fabricating a composite electrode for all-solid-state fluoride-ion batteries has not yet been established. A fabrication method for a composite electrode that disperses the active material and solid electrolyte is required. To approach this problem, in this study, we employed a high-pressure torsion (HPT) method, in which an active material, solid electrolyte, and conductive agent can be mixed with size reduction, as a new process and prepared Cu (active material)/PbSnF4 (solid electrolyte)/acetylene black (conductive agent) cathode composites. The crystalline sizes of Cu and PbSnF4 were significantly reduced. The apparent grain boundary resistance was also reduced owing to the more homogeneous distribution in the cathode composites after HPT processing. These structural and morphological changes led to high electrochemical performances, compared to a cathode composite without HPT.
Grating-coupler-induced intersubband resonances in electron inversion layers of silicon (1986)

Resonant intersubband transitions in electron inversion layers on the three principal surfaces of Si have been studied with efficient grating couplers. For Si(111) and Si(110) both directly parallel excited and grating-coupler-induced depolarization-shifted resonances are observed and their dependence on the surface electric and depletion fields studied. For Si(100) intersubband resonances are investigated up to charge densities ${N}_{s}$=1.2\ifmmode\times\else\texttimes\fi{}${10}^{13}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}2}$. At high densities transitions in the primed subband system are observed. Also for Si(100), there is evidence for parallel excited resonance transitions, which are strictly forbidden for vertical transitions (\ensuremath{\Delta}k=0), but become allowed for grating-coupler-induced nonvertical transitions (\ensuremath{\Delta}k\ensuremath{\ne}0). On all three surfaces a strong interaction of the intersubband resonances with optical phonons in the adjacent ${\mathrm{SiO}}_{2}$ layer is found.
Dissociation of TNF-alpha from endotoxin-induced nitric oxide and acute-phase hypotension (1997)

We tested the concept that tumor necrosis factor-alpha (TNF-alpha) or platelet-activating factor (PAF) mediated Escherichia coli endotoxin lipopolysaccharide (LPS)-induced upregulation of nitric oxide (NO) and acute-phase hypotension (APH) in the rat. LPS (0.5 mg/kg i.v.) given to rats treated with saline or nonimmune goat-derived gamma-globulin (immunoglobulin G, 22 mg/kg i.m.) produced APH and increased plasma concentrations of TNF-alpha and nitrate and nitrite anions (reactive nitrogen intermediates; RNI) and NO in ex vivo incubates of polymorphonuclear neutrophils (PMN) and inducible NO synthase (iNOS) mRNA in PMN. Pretreatment of rats with a polyclonal TNF-alpha antibody (TNF-Ab, 22 mg/kg i.m.) abolished LPS-mediated increases in plasma TNF-alpha but failed to inhibit APH or the NO system. TNF-alpha (8.2 micrograms/kg i.v.) produced transient hypertension and sustained tachycardia and increased plasma TNF-alpha and PMN iNOS mRNA but not RNI. LPS and TNF-alpha decreased spontaneous and calcimycin (Ca2+ ionophore, 1 microM)- and PAF (1 microM)-mediated increases in head-space NO production by rings of mesenteric artery incubated ex vivo. TNF-Ab abolished all effects of TNF-alpha. PAF (25, 50, and 100 ng/kg) produced APH without increasing plasma TNF-alpha, RNI, or PMN iNOS mRNA. The PAF receptor antagonist BN-50730 (80 micrograms/kg i.v.) abolished PAF-induced APH and attenuated LPS-induced increases in RNI. We conclude that 1) LPS produces parallel but unrelated changes in TNF-alpha and RNI in plasma and PMN during the APH of endotoxemia; and 2) endogenous TNF-alpha is not required for LPS-mediated induction of iNOS mRNA, and PAF mediates LPS-induced APH.
Tabasco Valley, North Slope, Alaska, a shallow fluvial/estuarine reservoir mapped with 3D seismic data (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1997Tabasco Valley, North Slope, Alaska, a shallow fluvial/estuarine reservoir mapped with 3D seismic dataAuthors: Jon L. KonklerDoug S. HastingsDebra H. McGimseyHenry PosamentierMark H. LeanderJon L. KonklerARCO Alaska Inc., Doug S. HastingsARCO Alaska Inc., Debra H. McGimseyGeologic Solutions Inc., Henry PosamentierARCO Exploration and Production Technology Co., and Mark H. LeanderBP Exploration (Alaska, Inc.)https://doi.org/10.1190/1.1885857 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1885857FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Jon L. Konkler, Doug S. Hastings, Debra H. McGimsey, Henry Posamentier, and Mark H. Leander, (1997), "Tabasco Valley, North Slope, Alaska, a shallow fluvial/estuarine reservoir mapped with 3D seismic data," SEG Technical Program Expanded Abstracts : 2050-2050. https://doi.org/10.1190/1.1885857 Plain-Language Summary PDF DownloadLoading ...
Anatomical Factors Influencing the Stimulation Intensity of the Functional Electrical Stimulation of the Supraspinatus Muscle (2004)

Objective: This study was designed to evaluate the contribution of anatomical factors to the stimulation intensity needed for functional electrical stimulation (FES) of shoulder girdle muscles, especially the supraspinatus. Method: Anatomical dimensions, including the length of the arm and scapular spine, were measured in twenty three normal subjects. Depth and thickness of the supraspinatus and trapezius muscle were measured ultrasonographically. FES was applied for supraspinatus muscles, and the minimal intensity required to induce contraction was recorded. Correlations of intensity with the anatomical dimensions were investigated statistically. Results: The thickness of the supraspinatus muscle and the length of the scapular spine showed statistically significant correlations with the minimal intensity for FES of supraspinatus muscles. No other anatomical measurements showed significant correlation. Conclusion: The intensity required for FES was affected by the thickness and length of muscles, rather than other anatomical variables. The results of this study suggest that one of the major factors contributing to the determination of the intensity of FES is the size of muscles. If the intensity could be estimated before stimulation, based on the size of muscle, unnecessary discomfort of the patients would be avoided.
Effect of pyridoxal-5'-phosphate on aggregation of platelets from stored human concentrates induced by arachidonic acid (1996)

Conference Article| February 01 1996 Effect of pyridoxal-5'-phosphate on aggregation of platelets from stored human concentrates induced by arachidonic acid Marie-Louise Nolan; Marie-Louise Nolan 1Department of Biochemistry, University College Dublin, Belfield, Dublin 4, Ireland. Search for other works by this author on: This Site PubMed Google Scholar Michael G. Harrington; Michael G. Harrington 1Department of Biochemistry, University College Dublin, Belfield, Dublin 4, Ireland. Search for other works by this author on: This Site PubMed Google Scholar Ashur Eljamil Ashur Eljamil 1Department of Biochemistry, University College Dublin, Belfield, Dublin 4, Ireland. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (1): 95S. https://doi.org/10.1042/bst024095s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Marie-Louise Nolan, Michael G. Harrington, Ashur Eljamil; Effect of pyridoxal-5'-phosphate on aggregation of platelets from stored human concentrates induced by arachidonic acid. Biochem Soc Trans 1 February 1996; 24 (1): 95S. doi: https://doi.org/10.1042/bst024095s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: PLP: pyridoxal-5'-phosphate, Δ4Ach: arachidonic acid, PC: platelet concentrate, r.b.c.: red blood cell This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells (2017)

RNA-binding proteins (RBPs) have emerged as important regulators of invertebrate adult stem cells, but their activities remain poorly appreciated in mammals. Using a short hairpin RNA strategy, we demonstrate here that the 2 mammalian RBPs, PUMILIO (PUM)1 and PUM2, members of the PUF family of posttranscriptional regulators, are essential for hematopoietic stem/progenitor cell (HSPC) proliferation and survival in vitro and in vivo upon reconstitution assays. Moreover, we found that PUM1/2 sustain myeloid leukemic cell growth. Through a proteomic approach, we identified the FOXP1 transcription factor as a new target of PUM1/2. Contrary to its canonical repressive activity, PUM1/2 rather promote FOXP1 expression by a direct binding to 2 canonical PUM responsive elements present in the FOXP1-3' untranslated region (UTR). Expression of FOXP1 strongly correlates with PUM1 and PUM2 levels in primary HSPCs and myeloid leukemia cells. We demonstrate that FOXP1 by itself supports HSPC and leukemic cell growth, thus mimicking PUM activities. Mechanistically, FOXP1 represses the expression of the p21<sup>-CIP1</sup> and p27<sup>-KIP1</sup> cell cycle inhibitors. Enforced FOXP1 expression reverses shPUM antiproliferative and proapoptotic activities. Altogether, our results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 in regulating normal HSPC and leukemic cell growth.
Group-Delay-Based Temperature Sensing in Linearly-Chirped Fiber Bragg Gratings Using a Kerr Phase-Interrogator (2014)

We present a novel temperature sensor based on temperature dependence of reflection group-delay in a linearly chirped fiber Bragg grating. The reflection group-delay of a chirped grating changes with temperature leading to a variation in the phase of a sinusoidal optical signal reflected from the grating. A Kerr phase-interrogator converts the phase variation into power variation allowing for high-precision temperature sensing. A temperature sensor with a resolution of 0.0089°C and a sensitivity of 1.122 rad/°C is experimentally demonstrated.
Comparison of the diffraction characteristics of continuous wave, ultrashort laser pulse, and chirped ultrashort pulse diffracted by multilayer reflection volume holographic gratings (2011)

Volume holographic gratings (VHG) are of wide interest in many applications because of their properties of high diffraction efficiency, excellent wavelength selectivity and angular selectivity. Recently, because of more free parameters, multi-layer volume holographic gratings (MVHG) have become an ideal candidate for various promising technological applications such as optical interconnects, pulse shaping and optical filters. Therefore, some knowledge of the diffraction behaviors of such system would be very valuable for characterizing and optimizing such volume diffractive optical elements. In this paper, we extend the coupled wave theory of multi-layer gratings to study the Bragg diffraction properties of continuous wave, ultrashort laser pulse and chirped ultrashort pulse, and present a systematically theoretical analysis on the spectrum distribution of the diffracted intensities, the diffraction bandwidth of a system of MRVHG. The system of MRVHG is composed of multiple layers of reflection VHG separated by intermediate layers. The comparisons of the diffraction characteristics for these beams are investigated.