gebhart/patrepeval huggingface dataset:
Lipolysis-induced partitioning of free fatty acids to lipoproteins: effect on the biological properties of free fatty acids. (1995)

Free fatty acids (FFA) released during the lipolysis of triglyceride (TG)-rich lipoproteins in vivo are generally believed to be bound to serum albumin. When hypertriglyceridemic (HTG) sera were lipolyzed in vitro by purified bovine milk lipoprotein lipase (LpL), there was an 11- to 18-fold increase in serum FFA levels, and a major portion (> 80%) of the FFA in serum was partitioned to lipoprotein fractions. The greatest portion (33%) of FFA in lipolyzed HTG serum was associated with newly formed flocculent remnants that banded just below low density lipoproteins (LDL) in the density gradient tube. Very low density lipoprotein (VLDL), LDL, and high density lipoprotein (HDL) fractions in lipolyzed HTG serum contained 18- to 29-times more FFA molecules than those in prelipolysis serum. Analysis of the fatty acyl chain composition of FFA in lipolyzed HTG serum showed that the extent of partitioning of saturated FFA into the lipoprotein fractions relative to that of polyunsaturated FFA was about 4.5- to 11-times greater than that partitioned into the free protein fraction; most (84%) of FFA partitioned into flocculent remnants were saturated fatty acids. In vivo lipolysis of TG-rich lipoproteins in HTG subjects, induced by heparinization, resulted in only a small (2.8-fold) increase in serum FFA and little or no increase in the partitioning of FFA to lipoproteins. However, in vitro incubation of the postheparin serum at 37 degrees C for 90 min resulted in a 2.9- to 6.8-fold increase in the serum FFA level and the partitioning of > 66% of total serum FFA into lipoprotein fractions. Studies of the interaction of various plasma fractions from control and in vitro lipolyzed HTG serum with cultured mouse peritoneal macrophages (MPM) showed that FFA partitioned to lipoprotein fractions were highly cytotoxic to cultured MPM, whereas FFA partitioned to albumin at a 10 x greater concentration were not cytotoxic. The cytotoxic potencies of FFA bound to lipoproteins and albumin were further compared after in vitro incorporation of FFA (oleic acids) into LDL and to albumin. FFA bound to LDL but not to albumin were cytotoxic to cultured MPM; the cytotoxicity of FFA bound to LDL was more closely related to the FFA to LDL-cholesterol molar ratio than to the total FFA concentration in the culture dish. The ability of FFA bound to LDL and albumin to induce foam cell formation was studied in THP-1 monocyte-derived macrophages, which were less susceptible to cytotoxicity produced by FFA bound to LDL than MPM.(ABSTRACT TRUNCATED AT 400 WORDS)
Compact modeling and system implications of microring modulators in nanophotonic interconnects (2015)

Silicon microring modulators are critical components in optical on-chip communications. In this paper, we develop theoretical compact models for optical transmission, power consumption, bit-error-rate (BER), and electrical tuning of microring modulators. The proposed theoretical models have been extensively validated by fabricated devices from a number of designs and fabrication batches. Since the quality factor (Q) and the extinction ratio (ER) of the microring modulator are important to determine the BER and link power budget, we include accurate equations for the Q and the ER in our models. Based on the proposed models, we identify an extra power penalty for the electrical tuning, and an energy-efficient swing voltage for the microring modulator to achieve to minimum total energy consumption.
[A case of subclavian paraganglioma in the superior mediastinum extending to the neck]. (1992)

A 52-year-old female was admitted to our hospital with left anterior chest pain. On physical examination, an elastic hard mass sized in 3.0 x 2.5 cm was palpable at the left suprasternal area. Chest X-ray film showed a large mass shadow in the cervico-thoracic region, and CT films revealed a well-defined mass in the superior mediastinum which was heterogeneously enhanced by contrast medium. Operation was performed under the preoperative diagnosis of thymic tumor extending upwards. At operation, the tumor was located between the trachea and the left subclavian artery in the superior mediastinum displacing these structures and extending to the neck. Resected specimen which was 5.5 x 3.5 x 3.0 cm in size and 42 gm in weight was well encapsulated and highly vascularized. On microscopic findings, the tumor was finally diagnosed as paraganglioma. According to the classification of Glenner and Grimley, it was thought that the tumor originated from subclavian paraganglion in the superior mediastinum. Subclavian paraganglioma had rarely been reported in the literatures. As subclavian paraganglioma, our patient was the first reported case in Japan.
Phase-factor based beamforming to improve the visualization of hyper-echoic targets (2017)

Clear visualization of hyper-echoic targets such as bone surfaces in ultrasound imaging is desirable for accurate
registration of ultrasound to other imaging modalities or statistical models. Challenges such as strong reverberation,
off-axis reflections and speed-of-sound variation reduce the contrast and resolution of the targets. In
this paper, we propose a phase-factor based beamforming method which applies the Hilbert transform on delay
compensated channel data across the receive aperture. The accumulated phase is then calculated and utilized as
the weight in the beamforming output. Using this method, the reverberation artifact of a point target is reduced
about 9 dB compared with other beamforming methods such as delay and sum, Wiener, minimum variance and
coherent-factor based beamforming in a point target phantom study. The resolution and contrast of hyper-echoic
targets are also improved in a vertebrae phantom study.
Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging (2016)

The detection and characterisation of tumour-derived circulating epithelial tumor cells (CETCs) or circulating tumor cells (CTCs) have been a main focus of basic oncological research over previous years. Numerous studies in the past decade have shown that CTCs are a promising tool for the estimation of the risk for metastatic relapse. The present observational study describes treatment results using tumour imaging and the quantification of CTCs. A group of 14 patients with advanced carcinomas was followed during their anticancer treatments. CTC numbers were serially detected and treatment success was estimated by positron emission tomography-computed tomography. A connection was found between tumour remission and a decreasing CTC count in 83%, a connection between stable disease and stable CTC numbers in 78% and a connection between progressive disease (PD) and an increase in CTC count in 50% of cases. In the patients with PD, an incomplete response was observed affecting the CTCs, but not the solid region of the tumour. As a result of this study, it may be concluded that patients with solid tumours benefit from serial quantification of CTCs in addition to imaging, as this combination of techniques provides a more sensitive result than imaging alone.
A new versatile hardware platform for digital real-time simulation: Verification and evaluation (2012)

A new hardware platform for digital real-time simulation and control applications is introduced which is highly expandable and customizable due to its modular design and flexible, open interfaces. The system is based on digital signal processors (DSPs) and field programmable gate arrays (FPGAs). A detailed description of the processor and interface boards as core components of the system is given. A small-scale desktop system for hardware-in-the-loop real-time simulations is shown. Furthermore, modeling methodologies and commonly used integration techniques with regard to usual problems and practical implementation are presented. An actual implementation is presented as an example simulation which is used to verify the functionality and evaluate the performance of the real-time simulation platform. A real-time simulation of a buck converter with a time-step of 1 µs without FPGA co-processing is shown and the simulation results are compared to real hardware measurements. To address the common problem of inter time-step switching, solutions are discussed and two approaches are implemented and compared. In total, this paper presents a short overview of digital real-time simulation including modeling and integration, software implementation, hardware platform for code execution and hardware-in-the-loop testing.
Development of Slag Recycling Process in Hot Metal Desulfurization with Mechanical Stirring (2009)

In order to develop an environment-friendly steelmaking process, a slag recycling process for hot metal desulfurization by mechanical stirring was designed. The process was developed with 70 kg-scale hot metal experiments and actual plant tests. The recycled slag has a 70% desulfurization ability compared with that of virgin flux (CaO-5%CaF2). The lower efficiency of the recycled slag was caused by SiO2 contamination carried over from the previous process. There is no particular size requirement for the recycled slag, as the effect of the recycled slag size on the desulfurization ability is small. The ratio of CaO in the recycled slag to total CaO should be less than 60% in order to prevent an increase in the amount of slag.

Slag recycling operation can be repeated more than twice when the optimum conditions are applied. The slag recycling process was established in an industrial operation, and consumption of desulfurization flux decreased by 40% with the process compared with that without slag recycling. Slag hot recycling was adopted at another plant where consumption of desulfurization flux decreased by 50% compared to operation without slag recycling. The positive effect of hot slag recycling is estimated to be a result of the temperature of the recycled slag.
MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance (2014)

We conclude that dynamic alterations in miRNA expression occur early on during androgen deprivation therapy, and androgen receptor blockade. The cumulative effect of these altered miRNA expression profiles is the temporal modulation of multiple signaling pathways promoting survival and acquisition of resistance. These early events are driving the transition to castration resistance and cannot be studied in already developed CRPC cell lines or tissues. Furthermore our results can be used a prognostic marker of cancers with a potential to be resistant to ADT.
Mononuclear Heptacoordinated 3d-Metal Helicates as a New Family of Single Ion Magnets (2022)

The series of Co(II), Fe(II), and Ni(II) mononuclear coordination compounds of [CoL(NCS)2]·3DMSO (1), [CoL(H2O)2](ClO4)2·DMSO (2), [CoL(H2O)(EtOH)][CoCl4]·2H2O (2a), [FeL(NCS)2]·DMSO (3), and [NiL(NCS)2]·CH3CN (4) composition (where L is 2,6-bis(1-(2-(4,6-dimethylpyrimidin-2-yl)hydrazineylidene)ethyl)pyridine), with an [MLA2] coordination unit (where A is a pair of apical monodentate ligands), was synthesized. In compounds 1, 2, 2a, and 3, the ligand L is pentadentate, and cobalt and iron ions are placed in a heavily distorted pentagonal pyramidal coordination environment, while in 4 the Ni(II) ion is hexacoordinated. Easy plane-type magnetic anisotropy (D = 13.69, 11.46, 19.5, and 6.2 cm−1 for 1, 2, 2a, and 4, respectively) was established for cobalt and nickel compounds, while easy axis-type magnetic anisotropy (D = −14.5 cm−1) was established for iron compound 3. The cobalt coordination compounds 1 and 2 show SIM behavior under a 1500 Oe external magnetic field, with effective magnetization reversal barriers of 65(1) and 60(1) K for 1 and 2, respectively. The combination of Orbach and Raman relaxation mechanisms was shown to adequately describe the temperature dependence of relaxation times for 1 and 2. CASSCF/NEVPT2 calculations were performed to model the parameters of the effective spin Hamiltonian for the compounds under study.
Performance of MPI Parallel Applications (2006)

The study of the performance of parallel applications may have different reasons. One of them is the planning of the execution architecture to guaranty a quality of service. In this case, it is also necessary to study the computer hardware, the operating system, the network and the users behavior. This paper proposes different models for those based on simulation. First results of this work show the impact of the network and the necessary precision of communication model in fine-grained parallel applications.
Historical and Literary Background of Migration and Devender Isar’s Nostalgia (2022)

Expressing melancholy and emotional yearning of the past time, called Nostalgia is cause of people movement from homeland to other city, state, country or region, seeking for employment, education, political asylum, citizenship or persuading security in safer and less crimes places or safeguard from environmental disaster etc. is called migration which, since long, has resulted in manifold complications. As an immigrant, despite of forcedly bifurcating from his homeland for one reason or the other, he can never eradicate his past memories and deep attachments with motherland. Soon after the division of subcontinent, people of the area also left their origin to settle down in new country for safety and security but during crossing the durned line, brutal violence and pitiless massacres on both sides caused enormous killing of family members and abduction of young girls and women.
A toolkit for building dependable and extensible home networking applications (2000)

Dependability and extensibility are two of the key requirements to successful home networking. In this paper, we describe the design and implementation of a software development toolkit for building dependable and extensible home networking applications. A reliable Soft-State Store (SSS) is implemented as a shared infrastructure to simplify robust distributed programming against device and object failures. SSS supports multi-timescale refreshes and selectively uses persistence to accommodate the battery power and network bandwidth constraints in the home networking environment. A publish/subscribe event system allows any changes in the SSS to be propagated to interested subscribers, which then perform appropriate adaptive, corrective, alerting, or cleanup actions. An Attribute-Based Lookup Service (ABLS) and a Name-Based Lookup Service (NBLS), both implemented on top of the SSS for robustness, provide a level of indirection for supporting extensibility as well as allowing userfriendly, natural language-based access. We demonstrate the use of the toolkit for building a home networking system in an actual deployment. We describe two end-to-end remote home automation applications, present performance results, and report our experiences. 1.
Metabolic Syndromes as Important Comorbidities in Patients of Inherited Retinal Degenerations: Experiences from the Nationwide Health Database and a Large Hospital-Based Cohort (2021)

This study aimed to evaluate the medical and socioeconomic impacts of IRDs using the nationwide health database and a large hospital-based cohort. This retrospective cross-sectional cohort study used data from the nationwide National Health Insurance Research Database (NHIRD). All patients with IRD from January 2012 to December 2016 were selected from the NHIRD and matched with the general population at a ratio of 1:4. All variables, including comorbidities, medications, service utilization, and medical costs, within 1 year from the date of the IRD diagnosis, were analyzed. Disability data were retrieved from the Taiwan Inherited retinal degeneration Project (TIP), a medical center-based database. A total of 4447 and 17,788 subjects from the nationwide database were included in the IRD and control groups, respectively. The Charlson comorbidity index score was higher in the IRD group (0.74:0.52, <i>p</i> < 0.001). Yearly visits to the ophthalmology clinic were more frequent in the IRD group (6.80:1.06, <i>p</i> < 0.001), particularly to tertiary medical centers (<i>p</i> < 0.001). The IRD group showed greater odds ratios (OR) for metabolic syndrome-related comorbidities, including hypertension (OR = 1.18, 95% confidence interval (CI) 1.10 to 1.26) and diabetes (OR = 1.32, 95% CI 1.21 to 1.45), and double the average yearly medical cost (2104.3 vs. 1084.6 USD, <i>p</i> < 0.001) and ten times the yearly ophthalmology cost (369.1 vs. 36.1 USD, <i>p</i> < 0.001). The average disability level was 54.17% for all subjects. This study revealed the large medical and socioeconomic impacts of IRD on not only patients with IRD, but also their family members and the whole society.
Characterization of Functional Domains within the Multifunctional Transcription Factor, YY1 (1995)

YY1 is a multifunctional transcription factor capable of either activation or repression of transcription. Using a series of mutant proteins, we have characterized domains responsible for activation or repression. We found that the YY1 transcriptional activation domain lies near the amino terminus and requires amino acids 16-29 and 80-100 for maximal activity. The region between residues 16 and 29 has the potential to form an acidic amphipathic helix, whereas residues between 80 and 100 are rich in proline and glutamine. The YY1 repression domain lies near the carboxyl terminus and is embedded within the YY1 zinc finger region necessary for binding to DNA. Deletion of YY1 amino acids, which include zinc fingers 3 and 4, abolishes repression. However, site-directed mutagenesis, progressive deletion, and internal deletion mutant analyses indicate that the normal structures of zinc fingers 3 and 4 are not required for repression.
Supplementary Table S5 from TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome (2023)

&lt;p&gt;Supplementary Table S5. Mutation summary in patients.&lt;/p&gt;
Realization of different electric signal fire resistant cables and carrying out of a &#x2018;real scale&#x2019; test. analysis and discussion of the obtained results (2007)

The installation of fire resistant cables in the electric power networks inside buildings and public areas (e.g. undergrounds, cinemas, theatres, etc.) is a key factor for people's safety. For this reason such cables must respond to very severe requirements, settled in many international standards. The present research work investigates the influence of several manufacturing parameters of low voltage fire resistant cables on their behaviour during standard fire tests. The aim of the work is to relate the manufacturing characteristics of several cable models with the relevant fire test output data via statistical analysis (i.e. Weibull and Design of Experiments (DoE) analysis) in order to optimize the cables for fire resistance purposes and minimize the production cost.
Vapour-liquid-solid growth of ZnO-ZnMgO core–shell nanowires by gold-catalysed molecular beam epitaxy (2019)

Nanowire heterostructures, combining multiple phases within a single nanowire, modify functional properties and offer a platform for novel device development. Here, ZnO/ZnMgO core-shell nanowires are grown by molecular beam epitaxy. At growth temperatures above 750 °C, Mg diffuses into ZnO making heterostructure growth impossible; at lower shell-growth temperatures (500 °C), the core-shell structure is retained. Even very thin ZnMgO shells show increased intensity photoluminescence (PL) across the ZnO band-gap and a suppression in defect-related PL intensity, relative to plain ZnO nanowires. EDX measurements on shell thickness show a correlation between shell thickness and core diameter which is explained by a simple growth model.
Scattering matrix approach to the design of infinite planar reflectarray antennas (2009)

In this paper, the procedure for modelling a unit cell in an infinite reflectarray antenna will be proposed and verified. The scattering matrix of the model will be derived using a commercial full wave simulator. Using the derived model the total input reflection coefficient is predictable for different loads without repeating the full wave simulation. This approach could be used in the design of MEMS-based reflectarray antennas.
A method for P‐P and P‐S mode separation in the presence of statics (2000)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2000A method for P‐P and P‐S mode separation in the presence of staticsAuthors: Saul E. GuevaraPeter W. CarySaul E. GuevaraThe CREWES Project, U. of Calgary/ECOPETROL and Peter W. CarySensor Geophysical Ltd.https://doi.org/10.1190/1.1815613 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1815613FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2000ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2000 Pages: 2484 publication data© 2000 Copyright © 2000 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 04 Jan 2005 CITATION INFORMATION Saul E. Guevara and Peter W. Cary, (2000), "A method for P‐P and P‐S mode separation in the presence of statics," SEG Technical Program Expanded Abstracts : 1225-1228. https://doi.org/10.1190/1.1815613 Plain-Language Summary PDF DownloadLoading ...
Synthesis of switching controllers using approximately bisimilar multiscale abstractions (2011)

When available, discrete abstractions provide an appealing approach to controller synthesis. Recently, an approach for computing discrete abstractions of incrementally stable switched systems has been proposed, using the notion of approximate bisimulation. This approach is based on sampling of time and space where the sampling parameters must satisfy some relation in order to achieve a certain precision. Particularly, the smaller the sampling period, the finer the lattice approximating the state-space and the larger the number of states in the abstraction. This renders the use of these abstractions for synthesis of fast switching controllers computationally prohibitive. In this paper, we present a novel class of multiscale discrete abstractions for switched systems that allows us to deal with fast switching while keeping the number of states in the abstraction at a reasonable level. The transitions of our abstractions have various durations: for transitions of longer duration, it is sufficient to consider abstract states on a coarse lattice; for transitions of shorter duration, it becomes necessary to use finer lattices. These finer lattices are effectively used only on a restricted area of the state-space where the fast switching occurs. We show how to use these abstractions for multiscale synthesis of self-triggered switching controllers for reachability specifications under time optimization. We illustrate the merits of our approach by applying it to the boost DC-DC converter.