gebhart/patrepeval huggingface dataset:
HIV Tat Protein Induces the TGF‐β Signaling Pathway and Suppresses the CFTR Biogenesis and Activity by microRNA‐Regulated Gene‐Silencing Mechanism (2020)

The advent of combination antiretroviral therapy (cART) has led to a dramatic decline in morbidity and mortality from HIV/AIDS. HIV infected subjects are still six times more likely to contract pneumonia compared to non‐infected age matched controls. Mortality, following an episode of bacterial pneumonia was also four times higher in HIV infected subjects compared to non‐infected controls. Thus, pneumonia can also contribute to HIV progression. Understanding the pathophysiological mechanisms that lead to microbial colonization of the airways in HIV infected patients is therefore important to public health. HIV Tat and CS can suppress CFTR function, which is a critical determinant of ASL depth and this can lead to depressed MCC and consequent microbial colonization. Our study showed that HIV‐infected cells in the airway namely alveolar macrophages, other immune cells or bronchial epithelial cells can serve as reservoirs and a source of HIV proteins like Tat which upregulates TGF‐beta mRNA in primary human bronchial epithelial cells with a corresponding decrease in CFTR mRNA. Chromatin immunoprecipitation with RNA Polymerase II demonstrated that transcription from the CFTR promoter is unaffected and blocking the miRNA processing pathway with Aurin Tricarboxylic acid (ATA) restore CFTR inhibition caused by TGF‐ beta. Our data showed that HIV infection suppress CFTR mRNA and function and blocking TGF‐beta signaling rescues this. Together this posits a strong role for (TGF‐beta induced) miRNA in Tat mediated CFTR gene silencing. Support or Funding Information Flight Attendant Medical Research Institute (FAMRI) Hypothesis Figure 1 HIV Tat suppresses CFTR via common TGF‐beta signaling Figure 2
Seaweed as Plant Biostimulants (2022)

Seaweeds have been used since ancient times as soil fertilizer and to turn infertile soil into fertile soil. Seaweeds’ research permitted in the last years to profile various species of seaweeds and their valuable compounds for various fields, such as human food, animal feed, biomedical, and pharmaceutical. In this case, with the pressure to turn agriculture more eco-friendly and lowering the usage of synthetic products, there was a gain in the research for seaweed compounds as plant biostimulants. However, in some countries of the North Atlantic Area, there was a tradition of collecting the seaweeds that came ashore. In Portugal, the most relevant one is named “sargaço.” This chapter explores not only the seaweeds as plant biostimulants but also the data already published about “sargaço” species as plant biostimulants to understand the potential of this tradition.
Lazy Reference Counting for Transactional Storage Systems (1997)

HAC is a novel technique for managing the direct the client cache in a distributed, persistent object storage system. In a companion paper, we showed that it outperforms other techniques across a wide range of cache sizes and workloads. This report describes HAC's solution to a specific problem: how to discard indirection table entries in an indirect pointer swizzling scheme.
A simple new write scheme for low latency operation of phase change memory (2012)

The behavior of resistance drift after RESET operation for phase change memory (PCRAM) is investigated. We propose, for the first time, an effective way to accelerate the drift so that the program/read latency may better match that for DRAM for SCM (storage class memory) application. By simply applying an extra annealing pulse after RESET we can quickly anneal out many defects (that are responsible for the drift) and provide a drift-free period that enlarges the read window. A physical model is proposed to understand the defect annealing phenomenon, which predicts the resistance drift behavior well.
The urokinase receptor as an effector of G protein-coupled receptors (2002)

Conference Abstract| February 01 2002 The urokinase receptor as an effector of G protein-coupled receptors Francesco Blasi Francesco Blasi 1San Raffaele Scientific Institute, Via Olgettina 58, Milan, 20132 Italy Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2002) 30 (1): A14. https://doi.org/10.1042/bst030a014 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Francesco Blasi; The urokinase receptor as an effector of G protein-coupled receptors. Biochem Soc Trans 1 February 2002; 30 (1): A14. doi: https://doi.org/10.1042/bst030a014 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2002 Biochemical Society2002 Article PDF first page preview Close Modal You do not currently have access to this content.
Supplementary Table S2 from Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;Primary human Ph-like sample&lt;/p&gt;
Chipmunk: Simple Distributed Object Storage for Named Data Networking (2022)

In NDN, data should be kept as close as possible to edge so that it can be processed and analyzed closer to its source as in IP-based edge computing. That will help reduce the traffic and meet the latency requirements of emerging applications more easily. NDN is inherently equipped with the feature by supporting caching of data temporarily in network nodes. But persistent storage is still required to store data. As of today, a number of persistent storage solutions have already been proposed and used for diverse applications. In this paper, we present a novel distributed object storage in NDN, Chipmunk, where the actual file storage of data is separated from its metadata. We show through the tests on the prototype implementation that Chipmunk provides easier and simpler than and comparable object storage to existing ones. The paper also discusses how to improve the effectiveness of Chipmunk as a future work.
3. Use of Uric Acid Lowering Drugs in CKD (2018)

「CKD診療ガイド2012」（日本腎臓学会，2012年）に「CKDにおける尿酸管理」の章が設けられている1）．これは2012年版で新たに設けられたものであり，その背景には，慢性腎臓病（chronic kidney disease：CKD）の発症・進展に及ぼす高尿酸血症の意義についての知見が集積してきたこと，及び我が国において新たな尿酸生成抑制薬が上市され，尿酸のマネージメントに注目が集まり始め，CKD診療の現場での道標が求められるようになった状況がある．本稿では，CKD患者における高尿酸血症治療について，尿酸降下薬の用い方を中心に解説する．
Supplementary M&M from Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells (2023)

&lt;p&gt;Supplementary materials and methods&lt;/p&gt;
Cox Regression with Correlation Based Regularization for Electronic Health Records (2013)

Survival Regression models play a vital role in analyzing time-to-event data in many practical applications ranging from engineering to economics to healthcare. These models are ideal for prediction in complex data problems where the response is a time-to-event variable. An event is defined as the occurrence of a specific event of interest such as a chronic health condition. Cox regression is one of the most popular survival regression model used in such applications. However, these models have the tendency to over fit the data which is not desirable for healthcare applications because it limits their generalization to other hospital scenarios. In this paper, we address these challenges for the cox regression model. We combine two unique correlation based regularizers with cox regression to handle correlated and grouped features which are commonly seen in many practical problems. The proposed optimization problems are solved efficiently using cyclic coordinate descent and Alternate Direction Method of Multipliers algorithms. We conduct experimental analysis on the performance of these algorithms over several synthetic datasets and electronic health records (EHR) data about heart failure diagnosed patients from a hospital. We demonstrate through our experiments that these regularizers effectively enhance the ability of cox regression to handle correlated features. In addition, we extensively compare our results with other regularized linear and logistic regression algorithms. We validate the goodness of the features selected by these regularized cox regression models using the biomedical literature and different feature selection algorithms.
A high-voltage level shifter with sub-nano-second propagation delay for switching power converters (2016)

A level-shifting circuit with sub-nano-second propagation delay for high input voltage switched-mode power converters is presented. The proposed circuit uses isolated low-voltage NMOS transistors and capacitive coupling to shift the control signal of the high-side power switch from a low-voltage logic domain (VLogic ~ 5V) up to a high-voltage power domain (VIN ~ 65V) with less than 115ps propagation delay. As a result, the non-overlap time inserted between the control signals of the high-side and low-side power switches can be minimized, leading to higher efficiency. Moreover, the control signal is shifted to the high-voltage power domain without reducing its voltage swing, which helps minimizing the on-resistance of the switch and further improves efficiency. The proposed circuit is fully integrated in a 0.18μm technology with no off-chip components. It occupies less than 0.75mm2 and provides built-in protection for the low-voltage devices with no additional protection circuitry. Transistor level simulations demonstrate the circuit's functionality and performance.
Modeling of a Hybrid-Hydraulic Electric Vehicle (2012)

This paper introduces modeling of a gearless hydraulic transmission system that provides an infinite speed ratio like continuous variable transmission (CVT). The transmission system is modeled in various operating conditions such as all-electric and gasoline configurations. The results demonstrate the high performance operation of the transmission system.
Vascular endothelial growth factor and matrix metalloprotease in lymphomatous meningitis (2008)

2031 Background: Because vascular endothelial growth factor (VEGF) and matrix metallproteases (MMPs) promote tumor angiogenesis, we determine whether cerebrospinal fluid (CSF) levels of VEGF165 and MMPs correlated with cytology in lymphomatous meningitis. Methods: One hundred twenty-two CSF samples were obtained from 42 patients with suspected lymphomatous meningitis. These samples were analyzed using enzyme-linked immunosorbent assay (ELSIA) for VEGF165, MMP-9, and MMP-2, as well as sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) zymography for MMP-9, activated MMP-9, MMP- 2, and activated MMP-2. Results: Samples with positive cytologies had a median white blood cell count of 11 cells/μL versus 1 cell/μL for those with negative cytologies (P=0.09). Using ELISA, we detected a median VEGF165 level of 4.72 pg/mL for positive and 1.02 pg/mL for negative CSF cytologies (P=0.009). While the normalized median MMP-9 levels by ELISA were not significant, 1.01 for positive versus 1.01 for negative CSF cytology (P=0.42), MMP-9 activity assayed by zymography was significant. Mean MMP-9 levels were significantly higher in CSF samples with atypical cytology as compared to negative cytology, 89.35 versus 2.52 (P=0.0175), and when both positive and atypical cytologies were combined as compared to negative cytology, 49.74 versus 2.52 (p=0.180). There was no significant correlation between CSF cytology and activated MMP-9, MMP-2, activated MMP-2, total protein, or glucose. Conclusions: CSF VEGF165 level and MMP-9 activity correlated with lymphomatous meningitis. Our MMP-9 ELISA did not detect a correlation due to poor sensitivity, but our SDS-PAGE zymography did. Both VEGF165 and MMP-9 may be components of the angiogenesis pathway in lymphoma meningitis. No significant financial relationships to disclose.
Biodistribution and Elimination Study of Fluorine-18 Labeled Nε-Carboxymethyl-Lysine following Intragastric and Intravenous Administration (2013)

PET technology is a powerful tool for the in vivo analysis of the gastrointestinal absorption of orally administered drugs. (18)F-CML is hardly absorbed by the gastrointestinal tract. It is rapidly distributed and eliminated from blood following intravenous administration. Thus, it may not be harmful to healthy bodies. Our study showed the feasibility of noninvasively imaging (18)F-labeled AGEs and was the first to describe CML-peptide gastrointestinal absorption by means of PET.
Robust stability of PWM buck DC-DC converter (2002)

Very recent techniques of robust stability are employed to investigate the robust stability of a pulse-width modulated buck DC-DC converter. It is shown that the compensated system of the device remains stable when the filter capacitor and the equivalent series resistance of the filter capacitor vary over large intervals around their nominal values.
Thin film optical coatings: errata (1978)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. Mouchart, "Thin film optical coatings: errata," Appl. Opt. 17, 1486-1486 (1978) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Fault Classification and Fault Signature Production for Rolling Element Bearings in Electric Machines (2004)

Most condition monitoring techniques for rolling element bearings are designed to detect the four characteristic fault frequencies. This has lead to the common practice of categorizing bearing faults according to fault location (i.e., inner race, outer race, ball, or cage fault). While the ability to detect the four characteristic fault frequencies is necessary, this approach neglects another important class of faults that arise in many industrial settings. This research introduces the notion of categorizing bearing faults as either single-point defects or generalized roughness. These classes separate bearing faults according to the fault signatures that are produced rather than by the physical location of the fault. Specifically, single-point defects produce the four predictable characteristic fault frequencies while faults categorized as generalized roughness produce unpredictable broadband changes in the machine vibration and stator current. Experimental results are provided from bearings failed in situ via a shaft current. These results illustrate the unpredictable and broadband nature of the effects produced by generalized roughness bearing faults. This issue is significant because a successful bearing condition monitoring scheme must be able to reliably detect both classes of faults.
Rita Tewari: malaria parasite cell division (2022)

Rita Tewari is a Professor of Parasite Cell Biology at The University of Nottingham, Faculty of Medicine and Health Sciences. We asked her about her recent paper published in Life Science Alliance (LSA) and her experience in science thus far.
ChemInform Abstract: A General Approach to the Synthesis of Polyquinenes via the Weiss Reaction. Part 10. Transient Formation of cis‐Tetracyclo‐(7.2.1.04,11. 06,10)doceca‐3,5,7,9‐tetraene and an Approach Toward 10,11‐Dimethyl‐ cis‐tetracyclo(7.2.1.04,11.06,10)dodeca‐3,5,7,9‐tetraene. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Influence of Protein Kinase C Activation on Basophils from Patients with Atopic Dermatitis in Comparison with Nonatopic Controls (1993)

Protein kinase C (PKC) is suggested to be important for signal transduction of histamine-containing cells. The present study investigated the putative role of PKC in enhanced mediator release of basophils in atopic dermatitis (AD). Basophils were isolated from patients with severe AD (mean serum IgE level of 5,165 U/ml) and from healthy controls, and the effects of potent activators of PKC on histamine release were studied. The phorbol esters 12-o-tetradecanoyl-phorbol-13-acetate and phorbol-12,13-dibutyrate and the nonphorbol mezerein induced a dose-dependent mediator release, which was significantly lower in 'atopic' basophils at concentrations > or = 1 microM. Recently, PKC levels have been shown to be lowered in atopic leukocytes compared to cells from healthy controls. The lowered response of PKC towards direct activation and lowered PKC levels may be due to high serum IgE levels and allergen exposure in vivo with subsequent down-regulation of different key elements of signal transduction.
A single-chip dual-tone and dial-pulse signaling receiver (1982)

A fully integrated central office DTMF/dial pulse receiver using switched capacitor filters and digital signal processing techniques, fabricated in double silicon NMOS, will be reported. The 36mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> 400mW chip operates from ± 5v supplies.
Boron Nitride Interphase in Ceramic‐Matrix Composites (1991)

A BN interphase has been deposited, by isothermal/isobaric chemical vapor infiltration (ICVI) from BF 3 ─NH 3 , within a preform made from ex‐polycarbosilane (ex‐PCS) fibers, at about 1000°C. In a second step, the BN‐treated preform was densified with SiC deposited from CH 3 SiCl 3 ─H 2 at about the same temperature. From a thermodynamic standpoint, ex‐PCS fibers could be regarded as unreactive vs the BF 3 ─NH 3 gas phase assuming they are coated with a thin layer of carbon or/and silica. The as‐deposited interphase consists of turbostratic BN (N/B &lt; 1) containing oxygen. The SiC infiltration acts as an annealing treatment: (i) the BN interphase becomes almost stoichiometric and free of oxygen; (ii) the fibers undergo a decomposition process yielding a SiO 2 /C layer at the BN/fiber interface. The weaker link in the interfacial sequence seems to be the BN/SiO 2 interface. Deflection of microcracks arising from the failure of the matrix takes place at (or nearby) that particular interface.
Exceptional Photonic Properties Through Click Chemistry and Self‐Assembly of Fluorodendrimers and Polymers (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A DOUBLE-MASKED, RANDOMIZED, SHAM-CONTROLLED, SINGLE-CENTER STUDY WITH PHOTOBIOMODULATION FOR THE TREATMENT OF DRY AGE-RELATED MACULAR DEGENERATION (2019)

Photobiomodulation treatment statistically improved clinical and anatomical outcomes with more robust benefits observed in subjects with earlier stages of dry age-related macular degeneration. Repeated PBM treatments are necessary to maintain benefits. These pilot findings support previous reports and suggest the utility of PBM as a safe and effective therapy in subjects with dry age-related macular degeneration.
Features of Situations: A Two-Mode Clustering Study of Situation Prototypes (1995)

A new statistical procedure, two-mode clustering analysis, was used to examine consensual beliefs about the features of situations typically occurring within the university milieu. Forty-eight students were asked to keep a written record of the situations they encountered over a 1-week period. The 30 most frequently mentioned situation labels were presented to an independent sample of subjects for rating on bipolar scales. A two-mode hierarchical clustering analysis of the situation-by-feature rating data yielded nine clusters showing how situations relate to each other, how situation-descriptive features relate to each other, and, most important, how situations and features relate to each other Additionally, an overlapping clustering solution was derived illuminating the fuzzy nature of situation categories. Implications of the present methodology for research on situation cognition are discussed.
Approaches to Urban Soundscape Management, Planning, and Design (2015)

Binaural hearing allows for localizing sound sources, suppressing noise, for example, for a better understanding of speech, and forming an impression of spaciousness. In order to analyze acoustical environments appropriately, it is necessary to use human hearing-related measurement methods. For example, measurements with binaural technology enable us to reexperience the acoustic environment in an acoustically sense. Moreover, by means of the knowledge of psychoacoustics, several basic auditory sensations can be described in detail beyond the impression of loudness. This chapter introduces binauralCONTENTS6.1 Measurement Equipment 134 6.1.1 Introduction to Anatomy and Signal Processingof Human Hearing 134 6.1.2 Derivation of Requirements for Measurement Equipment 136 6.1.3 Introduction to Binaural Measurement Equipment 1376.2 Measurement Conditions and Specifications 139 6.2.1 Derivation of Measurement Specificationsdue to Human Hearing Performance 139 6.2.2 Derivation of Measurement Conditions 1406.3 Analysis of Acoustic Environments by Means of Psychoacoustics 142 6.3.1 Introduction to Psychoacoustics 142 6.3.2 Psychoacoustic Analysis of Acoustic Environments(Soundwalk Data) and Basic Classification of Acoustic Environments (Soundscapes) Based on Psychoacoustic Profiles 1496.4 Characterization of Soundscapes 156 6.4.1 Options and Limitations of Psychoacoustic Analysis 156 6.4.2 Meaning of Source Recognition and Listening Focus 157 6.4.3 Outlook 158References 158measurement technology and psychoacoustics, which are considered necessary components of a comprehensive soundscape investigation.
A novel fast time jamming analysis transmission selectiontechnique for radar systems (2021)

The jamming analysis transmission selection (JATS) sub-system is used in radar systems to detect and avoid the jammed frequencies in the available operating bandwidth during signal transmission and reception. The available time to measure the desired frequency spectrum and select the non-jammed frequency for transmission is very limited. A novel fast time (FAT) technique that measures the channel spectrum, detects the jamming sub-band and selects the non-jammed frequency for radar system transmission in real time is proposed. A JATS sub-system has been designed, simulated, fabricated and implemented based on FAT technique to verify the idea. The novel FAT technique utilizes time-domain analysis instead of the wellknown fast Fourier transform (FFT) used in conventional JATS sub-systems. Therefore, the proposed fast time jamming analysis transmission selection (FAT-JATS) sub-system outperforms other reported JATS sub-systems as it uses less FPGA resources, avoids time-delay occurred due to complex FFT calculations and enhances the real time operation. This makes the proposed technique an excellent candidate for JATS sub-systems.
Contrasting work environments of medical school faculty 1 (1991)

An attitude survey has revealed vividly contrasting institutional atmosphere and working conditions at U.S. medical schools. Environments at about one-fourth of the schools were judged to be highly positive with regard to subjective atmosphere, career development, and faculty-administration relations. Environments at another one-fourth of all schools were judged to be highly negative in all of these areas. Recognizing the existence of these differences is necessary before administrative remedies for many of the problems at the latter group of schools can be implemented.