gebhart/patrepeval huggingface dataset:
Effects of GLP-1 and 2,5-anhydro-D-mannitol on insulin secretion and plasma glucose in mice (1995)

The truncated glucagon-like peptide-1 (GLP-1(7-36)amide or GLP-1) stimulates insulin secretion, enhances glucose elimination and is of potential interest in diabetes treatment. We studied the hypoglycemic action of GLP-1 in normal mice when given alone or together with the fructose analogue, 2,5-anhydro-D-mannitol (2,5-AM), which inhibits glycogenolysis and gluconeogenesis. GLP-1 (32 nmol/kg iv) lowered plasma glucose levels after 25 min to 4.6 +/- 0.2 mmol/l compared with 7.3 +/- 0.4 mmol/l in controls (P < 0.001). Also 2,5-AM (0.5 mumol/kg iv) reduced plasma glucose levels, to 5.6 +/- 0.3 mmol/l (P < 0.01). When given together, the glucose lowering action of GLP-1 and 2,5-AM was additive, since the 25 min glucose level was 2.8 +/- 0.2 mmol/l. At 5 min after injection, GLP-1 had increased plasma insulin levels to 693 +/- 68 pmol/l compared with 342 +/- 42 pmol/l in controls (P < 0.01). 2,5-AM abolished this increase. Furthermore, GLP-1 (32 nmol/kg) did not affect the glycogen content, neither in the liver nor in the gastrocnemic muscle in samples taken at 30 min after injection. Moreover, in isolated islets incubated at 3.3 and 8.3 mmol/l glucose, 2,5-AM at 75 mmol/l inhibited glucose-stimulated insulin secretion (P < 0.05) showing that 2,5-AM inhibits insulin secretion both in vivo and in vitro. We conclude that GLP-1 may reduce plasma glucose levels also to levels below the basal levels under normal conditions, and that an insulin- and liver-independent action of the peptide contributes to its hypoglycemic action in normal animals.
Silicon-Germanium Avalanche Receivers With fJ/bit Energy Consumption (2021)

Fast, low-noise and sensitive avalanche photo-receivers are needed for surging short-reach photonic applications. Limitations concerning bandwidth, throughput and energy consumption should be overcome. In this work, we comprehensively study the performance opportunities provided by avalanche p-i-n photodetectors with lateral silicon-germanium-silicon heterojunctions. Our aim is to circumvent the need for chip-bonded electronic amplifiers. In particular, we demonstrate that avalanche photodetectors based on silicon-germanium-silicon heterostructures yield reliable opto-electrical performances, with high gain-bandwidth products up to 480 GHz and low effective ionization ratios down to 0.15. Moreover, they improve power sensitivities for high-speed optical signals and have a low energy dissipation of only a few fJ per received information bit. These results pave the way for high-performing receivers for energy-aware data links, in next-generation short-distance data communications.
Board leadership structure and firm performance: An examination of resource dependence role (2011)

This study examines if the CEO duality influence the firm economic performance in Bangladesh and the moderating effects of board composition in the form of outside independent directors. While doing so, it examines the relationship between CEO duality and firm performance during the pre appointment of outside independent directors and post appointment of outside independent directors (the role of other corporate governance mechanism as moderating variable). The finding is that there is there is a negative (non-significant) relationship between CEO duality and firm performance before appointment of outside independent directors in the board. However, independent leadership structure and firm performance is found to be positively related following the acquisition of resource (outside independent directors in the board) supporting the ’resource dependence theory’. The findings of this study partially support the ’agency theory’ and ’resource dependence theory’ but do not support the stewardship theory. This study contributes to the literature on CEO duality in the context of less a developed country.
Mixed-metal oxide based catalysts (2023)

One or more embodiments relates to a method of catalytically converting a reactant gas mixture for pollution abatement of products of hydrocarbon fuel combustion. The method provides substituted mixed-metal oxides where catalytically active metals are substituted within the crystal lattice to create an active and well dispersed metal catalyst available to convert the reactant gas mixture. Embodiments may be used with gasoline and diesel fueled internal combustion engine exhaust, although specific embodiments may differ somewhat for each.
Expression of c-kit Receptor and its Autophosphorylation in Immature Rat Type A Spermatogonia1 (1995)

The objective of this study was to examine the expression and activation of the c-kit receptor, a specific receptor for kit ligand (stem cell factor, steel factor), in rat type A spermatogonia. Testes were obtained from 9-day-old rats, decapsulated, and then subjected to sequential enzymatic digestion. The mixture of testicular cell types was then separated by sedimentation velocity at unit gravity. The isolated type A spermatogonia were characterized by light and electron microscopy. They exhibited spherical nuclei containing several nucleoli and associated chromatin clumps and organelles generally in a perinuclear location similar to that found in the in vivo 9-day-old testis. The synthesis of the c-kit receptor by the spermatogonia was established by hybridization of total RNA with a specific cDNA for mouse c-kit receptor. Two mRNA transcripts migrating at 4.8 kb and 12 kb were observed. Localization of the c-kit receptor in the isolated cells was determined by immunocytochemistry using an antibody to c-kit protein. Specific staining for c-kit receptor was observed in the cytoplasm of the isolated type A spermatogonia. Furthermore, the presence of the c-kit receptor protein in the spermatogonia was confirmed by Western blot analysis using the same antibody. The antibody recognized the c-kit receptor at approximately 160 kDa. In an attempt to determine whether this receptor has a functional significance, we examined the effect of kit ligand on the phosphorylation of the c-kit receptor. The c-kit receptor appeared to be constitutively autophosphorylated on tyrosine at low basal levels, and upon stimulation with kit ligand, the amount of phosphorylated protein increased significantly. These observations indicate that kit ligand induces autophosphorylation of the c-kit receptor, which may lead to the activation of other cellular target proteins responsible for spermatogonial proliferation and/or differentiation.
Topographical variations in the morphology and biochemistry of adult canine tibial plateau articular cartilage (1985)

Topographically, there are both morphological and biochemical differences in the articular cartilage of the tibial plateau of normal adult dogs when the cartilage covered by the meniscus is compared with that more centrally placed and not covered by meniscus. Histologically, differences are present in the surface morphology, in intra- and extracellular lipid content, and in the morphology of the mineralization front. Electron microscopy shows, in the covered cartilage, variability in collagen fiber size, with evenly spaced fibers apparently randomly distributed and an orderly relationship between the proteoglycans and collagen, whereas in the uncovered area, the collagen is aggregated into bundles and appears to be dissociated in large part from the proteoglycans. The most striking feature in the biochemistry of the two regions is an increased water content in the uncovered cartilage, as compared with the covered. In addition, there is an increased amount of proteoglycans that can be extracted in the uncovered cartilage. The heterogeneity of the cartilage on the tibial plateau should be taken into account when considering both the histologic and biochemical variations found in osteoarthritic cartilage; and when reflecting on the pathogenesis of osteoarthritis.
Historical Estimates of External Gamma Exposure and Collective External Gamma Exposure from Testing at the Nevada Test Site. II. Test Series After Hardtack II, 1958, and Summary (1990)

The historical data on the cumulative individual external gamma exposures are tabulated for communities around the Nevada Test Site for the time periods of 1961 to the signing of the Limited Test Ban Treaty on 5 August 1963, and from then until 1975. The collective exposures during the two time periods are calculated to be 610 and 320 person-R, respectively. The total collective external gamma exposure from 1951 through 1975 for these communities s calculated to be 86,000 person-R. The area considered includes the countries of Clark, Lincoln, Nye, and White Pine in Nevada and the countries of Iron and Washington in Utah; inclusion of Salt Lake City would have substantially increased the calculated collective exposure because of the large population. The methods of calculation are reviewed. Also, the historical data on the assessment of dose via ingestion are reviewed with emphasis on the dose to the thyroid of infants living in St. George, UT, at the time of fallout from event HARRY on 19 May 1953.
Effects of environmental acid on freshwater fish with particular reference to the software lakes in Ontario and the modifying effects of heavy metals. A literature review (1981)

This review examines the physiology of acid stress and the toxic effects of selected heavy metals in fish. Acid and metal stress may occur simultaneously in some Ontario soft water lakes due to atmospheric deposition and the leaching of bedrock and sediments. Fundamentals of normal acid-base regulation and its relationship to ionoregulation in fish are reviewed and updated. Toxic effects of low environmental pH are examined, and at pH values presently found in the field failure of ionoregulation appears to be the primary toxic response, at least in acute exposures. At more extreme pH's seldom encountered in the wild, anoxia and acid-base disturbance predominate. The toxic effects of metals enriched in acid waters (Al, Cd, Cu, Pb, Mn, Ni, Zn) are briefly reviewed. Concentrations of these metals at present are generally below Great Lakes water quality objectives but their physiological effects at low pH are little known and possibly significant. The dilute nature of acidified shield lakes suggests that the toxic effects of both stressors will be maximized especially since waterborne calcium, an important moderator of toxicity of both acid and metals, is scarce. Possible areas of synergism between acid and metals are outlined. Although mortalities of mature fish are occasionally seen, the critical population response observed in the field is failure of reproduction. To date the relative importance of either acidity, metals, or their interaction in causing reproductive failure has not been delineated.
Cryogenic Pressure Control Modeling for Ellipsoidal Space Tanks in Reduced Gravity (2008)

A computational fluid dynamics (CFD) model is developed to simulate pressure control of an ellipsoidal-shaped liquid hydrogen tank under external heating in low gravity. Pressure control is provided by an axial jet thermodynamic vent system (TVS) centered within the vessel that injects cooler liquid into the tank, mixing the contents and reducing tank pressure. The two-phase cryogenic tank model considers liquid hydrogen in its own vapor with liquid density varying with temperature only and a fully compressible ullage. The axisymmetric model is developed using a custom version of the commercially available FLOW-3D software and simulates low gravity extrapolations of engineering checkout tests performed at Marshall Space Flight Center in 1999 in support of the Solar Thermal Upper Stage Technology Demonstrator (STUSTD) program. Model results illustrate that stable low gravity liquid-gas interfaces are maintained during all phases of the pressure control cycle. Steady and relatively smooth ullage pressurization rates are predicted. This work advances current low gravity CFD modeling capabilities for cryogenic pressure control and aids the development of a low cost CFD-based design process for space hardware.
An investigation of the relation between tumor-to-liver ratio (TLR) and tumor-to-blood standard uptake ratio (SUR) in oncological FDG PET (2016)

Suitability of the liver as surrogate of arterial tracer supply for SUV normalization via TLR computation is limited. Further studies in sufficiently large patient groups are required to better characterize the relative performance of SUV, TLR, and SUR in different settings.
Development on Process for Producing Continuous Fine Diameter Filaments of Superconductors (1972)

Abstract : A process to produce the continuous niobium carbonitride filament yarn from both carbon and boron nitride precursors was developed. The process involved converting chemically the precursor yarns into niobium carbonitrides with niobium pentachloride in the presence of hydrogen and nitrogen. The superconductive filament yarns produced were characterized by their superconducting and mechanical properties and their surface structures. Critical temperatures up to 19 K were observed for the superconductive filaments made by this method. The critical currents of some of the filaments were determined to be 0.4-1.0 x 10 to the 5th power amp/sq cm in zero field. Procedures to prepare filaments with high flexibility and strength were also developed.
Estimating Stuck Fault Coverage in Sequential Logic Using State (2007)

Stuck fault coverage estimation for sequential circuits relies on a time expansion model, where combinational techniques are employed for each time-frame. Faults that are hard to detect and require a particular sequence of states are often incorrectly estimated to be detected. This problem is more evident for designs that exhibit low coverage either due to low testability or insufficient vectors that fail to exercise the required sequence of states. This paper illustrates how a simple state traversal analysis can mitigate this problem. For circuits with large number of sequential elements, we propose an entropy based technique that collapses the state graph to be analyzed. Experimental results for larger ISCAS benchmarks show that this technique reduces the coverage estimation error by as much as 50%.
Resorbable and Nonresorbable Hydroxyapatite Granules as Bone Graft Substitutes in Rabbit Cortical Defects (2003)

Our results suggest that both resorbable and nonresorbable HA granules promote new bone formation in rabbit cortical defects, which does not occur in control defects.
Liver-Directed Recombinant Adeno-Associated Viral Gene Delivery Rescues a Lethal Mouse Model of Methylmalonic Acidemia and Provides Long-Term Phenotypic Correction (2010)

Methylmalonic acidemia is a severe metabolic disorder caused by a deficiency of the ubiquitously expressed mitochondrial enzyme, methylmalonyl-CoA mutase (MUT). Liver transplantation has been used to treat a small number of patients with variable success, and whether liver-directed gene therapy might be employed in such a pleiotropic metabolic disorder is uncertain. In this study, we examined the therapeutic effects of hepatocyte-directed delivery of the Mut gene to mice with a severe form of methylmalonic acidemia. We show that a single intrahepatic injection of recombinant adeno-associated virus serotype 8 expressing the Mut gene under the control of the liver-specific thyroxine-binding globulin (TBG) promoter is sufficient to rescue Mut(-/-) mice from neonatal lethality and provide long-term phenotypic correction. Treated Mut(-/-) mice lived beyond 1 year of age, had improved growth, lower plasma methylmalonic acid levels, and an increased capacity to oxidize [1-(13)C]propionate in vivo. The older treated mice showed increased Mut transcription, presumably mediated by upregulation of the TBG promoter during senescence. The results indicate that the stable transduction of a small number of hepatocytes with the Mut gene can be efficacious in the phenotypic correction of an inborn error of organic acid metabolism and support the rapid translation of liver-directed gene therapy vectors already optimized for human subjects to patients with methylmalonic acidemia.
Safety evaluation after acute and sub-chronic oral administration of high purity nicotinamide mononucleotide (NMN-C®) in Sprague-Dawley rats (2021)

β-nicotinamide mononucleotide (NMN) is a natural molecule intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Preclinical evidences point to the beneficial effect of NMN administration on several age-related conditions. The present work aimed at studying mutagenicity, and genotoxicity, acute oral toxicity and subchronic oral toxicity of a high purity synthetic form of NMN (NMN-C®) following the OECD guidelines. In the experimental conditions tested, NMN-C® was not mutagenic or genotoxic. Acute toxicity assay revealed that at an oral limit dose of 2666 mg/kg, NMN-C® did not lead to any mortality or treatment-related adverse signs. Over a 90-day sub-chronic period of repeated oral administration of NMN-C® at doses of 375, 750 and 1500 mg/kg/d followed by a 28-day treatment-free recovery period, NMN-C® appeared to be safe and did not promote toxic effects as seen from body weight change, food and water consumption, feed conversion efficiency, biochemical and blood parameters as well as organ toxicity and histological examinations of main organs. In conclusion, we provide the first data highlighting the safety of short to intermediate term (sub-chronic) oral administration of NMN and our experimental results allowed to determine a No-Observable Adverse Effect Level (NOAEL) for NMN-C® to be ≥ 1500 mg/kg/d.
COMPASS: A suite of pre‐ and post‐search proteomics software tools for OMSSA (2011)

Here we present the Coon OMSSA Proteomic Analysis Software Suite (COMPASS): a free and open-source software pipeline for high-throughput analysis of proteomics data, designed around the Open Mass Spectrometry Search Algorithm. We detail a synergistic set of tools for protein database generation, spectral reduction, peptide false discovery rate analysis, peptide quantitation via isobaric labeling, protein parsimony and protein false discovery rate analysis, and protein quantitation. We strive for maximum ease of use, utilizing graphical user interfaces and working with data files in the original instrument vendor format. Results are stored in plain text comma-separated value files, which are easy to view and manipulate with a text editor or spreadsheet program. We illustrate the operation and efficacy of COMPASS through the use of two LC-MS/MS data sets. The first is a data set of a highly annotated mixture of standard proteins and manually validated contaminants that exhibits the identification workflow. The second is a data set of yeast peptides, labeled with isobaric stable isotope tags and mixed in known ratios, to demonstrate the quantitative workflow. For these two data sets, COMPASS performs equivalently or better than the current de facto standard, the Trans-Proteomic Pipeline.
Synthesis and Secretion of Hydroxyproline Containing Macromolecules in Carrots. I. Kinetic Analysis (1969)

When disks of carrot (Daucus carota) phloem parenchyma are incubated for 6 days there is a 10-fold increase in cell wall hydroxyproline due to the synthesis and secretion of hydroxyproline-containing macromolecules. The synthesis of these molecules and their secretion are demonstrated by measuring the kinetics of incorporation and of chase of (14)C-proline and hydroxyproline in different fractions of the cytoplasm and the cell wall. The hydroxyproline-containing molecules which are secreted are associated with the membranous organelles of the cytoplasm. They can be fractionated into trichloroacetic acid-soluble and trichloroacetic acid-precipitated fractions. The properties of the trichloroacetic acid-soluble fraction associated with the membranous organelles are consistent with its role as a cell wall precursor.
Introduction (2010)

Extract Middlemen are never heroes. Every immigrant community has middlemen because they serve an important function: they help immigrants deal with the larger society. Their work is often controversial. They may expect payment in loyalty, coin, tribute, or souls. Often, middlemen became immigrant communities’ most visible public figures, but their profile in history does not match their prominence in life.1Close This book explores some of the most controversial political middlemen in the history of Canada and the United States: Chinese immigrant leaders during the Chinese Exclusion Era.2Close It also probes the mystery of why their past became obscured. Between the 1880s and 1940s, Canada and the United States implemented policies that excluded and harassed Chinese immigrants. In the face of immigration exclusion, anti-Chinese laws, and mob violence,3Close Chinese sought political power to combat this discrimination. The Chinese Exclusion Act (1882–1943) barred the entry of all Chinese workers to the United States. Canada implemented a Chinese head tax (1885–1924) on entering Chinese workers, followed by the total exclusion of virtually all new Chinese immigrants (1923–1947).4Close In this setting, Chinese political middlemen improvised, creating unofficial ties to mainstream institutions. Their persistence heightened public unease about nonwhite immigrants, as many Canadians and Americans felt that Chinese political middlemen threatened democracy. Frequently, they saw the middlemen as exploiters of non-English-speaking Chinese workers, who treated the workers more like “yellow slaves” than free men and women.5Close The popular media often depicted middlemen as despots who ruled Chinatowns rife with Oriental intrigue. The media also described them as mediators so alluring that few of their non-Chinese neighbors could resist their supposed corrupting influence.6Close Fearing Chinese political power, Canada and the United States denied nearly all Chinese the right to vote.7Close
Validation of Inhalation Aerosols (2003)

Inhalation aerosols have been used for the delivery of drugs to the respiratory system since the mid-1950s. The most common dosage form for inhalation is the metered-dose inhaler (MDI), by which the drug is delivered from a pressurized container using a liquefied gas propellant. Medication delivered via this dosage form has allowed for a quick therapeutic response to the symptoms of asthma, emphysema, and chronic obstructive pulmonary disease (COPD), and has resulted in an improvement in the quality of life for millions of asthma sufferers.
Pharmacokinetics of GLP2-2G-XTEN in cynomolgous monkeys. (2015)

&lt;p&gt;GLP2-2G-XTEN plasma concentration is shown following 25 nmol/kg administration via intravenous (triangle) or subcutaneous (square) route. Three animals were dosed by each route of administration. Data points are the average ± s.d. of three animals per time point.&lt;/p&gt;