gebhart/patrepeval huggingface dataset:
Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-α (2013)

This finding indicates that early microglia overproduction of TNF-α in the injured brain region after TBI contributes to cerebral ischemia and neurological motor deficits, which can be attenuated by etanercept therapy. Studies in this model could provide insight into the mechanisms underlying neurological motor disturbance in brain-injured patients.
Theoretical frameworks for data mining (2000)

article Free Access Share on Theoretical frameworks for data mining Author: Heikki Mannila Nokia Research Center, Nokia Group, Finland Nokia Research Center, Nokia Group, FinlandView Profile Authors Info & Claims ACM SIGKDD Explorations NewsletterVolume 1Issue 2January 2000 pp 30–32https://doi.org/10.1145/846183.846191Published:01 January 2000Publication History 74citation2,361DownloadsMetricsTotal Citations74Total Downloads2,361Last 12 Months150Last 6 weeks26 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Low-force spectroscopy on graphene membranes by scanning tunneling microscopy (2018)

Two-dimensional atomically flat sheets with a high mechanical flexibility are very attractive as ultrathin membranes but are also inherently challenging for microscopic investigations. We report on a method using Scanning Tunneling Microscopy (STM) under ultra-high vacuum conditions for non-indenting low-force spectroscopy on micrometer-sized freestanding graphene membranes. The method is based on applying quasi-static voltage ramps with active feedback at low tunneling currents and ultimately relies on the attractive electrostatic force between the tip and the membrane. As a result a bulge-test scenario can be established. The convenience and simplicity of the method relies on the fact that the loading force and the membrane deflection detection are both provided simultaneously by the STM. This permits the continuous measurement of the stress-strain relation. Electrostatic forces applied are typically below 1 nN and the membrane deflection is detected at sub-nanometer resolution. Experiments on single-layer graphene membranes with a strain of 0.1% reveal a two-dimensional elastic modulus E<sub>2D</sub> = 220 N m<sup>-1</sup>.
Bethe surface, elastic and inelastic differential cross sections, Compton profile, and binding effects for H2 obtained by electron scattering with 25 keV incident electrons (1974)

Electron impact spectra for H2 have been obtained at scattering angles of 1°, 1.5°, 2°, 3°, 4°, 5°, 7°, and 10° using 25 keV incident electrons. The measured intensities were converted to generalized oscillator strengths and placed on an absolute scale at each scattering angle by the use of the Bethe sum rule for the generalized oscillator strength distribution. The cross section differential with respect to both solid angle and energy loss of the scattered electron was corrected for relativistic and exchange effects and integrated over energy loss to obtain the inelastic differential cross sections. In addition the elastic cross section differential with respect to solid angle was measured. The results are all in excellent agreement with theoretical calculations. The total elastic cross section was determined using additional data from another source. The Compton profile was determined from the 7° scattering data and was found to agree well with the previous x-ray results. Consistent generalized optical sums (2,1, − 1, − 2) and optical sum inequalities for the generalized oscillator strength were also obtained. In addition inelastic scattering factors were computed from the (−1) optical sum and were found to agree well with available theory. Chemical binding effects were explored using electron density difference functions obtained from the differential cross sections. For the first time the intensity difference functions for the elastic and inelastic scattering were determined separately. It is argued that the experimental method used in this study to obtain the intensity difference functions represents the best approach so far developed for obtaining direct information about molecular real space charge densities.
REGULATION OF REPRESSIBLE ACID PHOSPHATASE BY CYCLIC AMP IN SACCHAROMYCES CEREVISIAE (1984)

One of the cyr 1 mutants (cyr 1-2) in yeast produced low levels of adenylate cyclase and cyclic AMP at 25 degrees and was unable to derepress acid phosphatase. Addition of cyclic AMP to the cyr1-2 cultures elevated the level of repressible acid phosphatase activity. The bcy1 mutation, which suppresses the cyr1-2 mutation by allowing activity of a cyclic AMP-independent protein kinase, also allows acid phosphatase synthesis without restoring adenylate cyclase activity. The CYR3 mutant had structurally altered cyclic AMP-dependent protein kinase and was unable to derepress acid phosphatase. The cyr1 locus was different from pho2, pho4 and pho81, which were known to regulate acid phosphatase synthesis. Mutants carrying cyr1-2 and pho80, PHO81c, PHO82 or pho85 mutations, which confer constitutive synthesis of repressible acid phosphatase, produced acid phosphatase. The cyr1-2 mutant produced significantly low levels of invertase and alpha-D-glucosidase. These results indicated that cyclic AMP-dependent protein kinase exerts its function in the synthesis of repressible acid phosphatase and other enzymes.
Hardware reduction methodology for 2-dimensional kurtotic fastica based on algorithmic analysis and architectural symmetry (2009)

In this paper we propose a hardware reduction methodology through detailed algorithmic analysis and exploiting datapath symmetry for 2D Kurtotic Fast ICA. The relationship of the hardware saving with respect to input data frame-length and maximum iteration for convergence is also explored. An example architecture following the developed hardware reduction methodology consumes 3:55 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> silicon area and 27:1 muW @1 MHz at 1:2 V supply using 0:13 mum standard cell CMOS technology showing the effectiveness of the proposed methodology.
Darwin: A Genomics Co-processor Provides up to 15, 000X Acceleration on Long Read Assembly. (2019)

Genomics is transforming medicine and our understanding of life in fundamental ways. Genomics data, however, is far outpacing Moore»s Law. Third-generation sequencing technologies produce 100X longer reads than second generation technologies and reveal a much broader mutation spectrum of disease and evolution. However, these technologies incur prohibitively high computational costs. Over 1,300 CPU hours are required for reference-guided assembly of the human genome, and over 15,600 CPU hours are required for de novo assembly. This paper describes --- a co-processor for genomic sequence alignment that, without sacrificing sensitivity, provides up to $15,000X speedup over the state-of-the-art software for reference-guided assembly of third-generation reads. Darwin achieves this speedup through hardware/algorithm co-design, trading more easily accelerated alignment for less memory-intensive filtering, and by optimizing the memory system for filtering. Darwin combines a hardware-accelerated version of D-SOFT, a novel filtering algorithm, alignment at high speed, and with a hardware-accelerated version of GACT, a novel alignment algorithm. GACT generates near-optimal alignments of arbitrarily long genomic sequences using constant memory for the compute-intensive step. Darwin is adaptable, with tunable speed and sensitivity to match emerging sequencing technologies and to meet the requirements of genomic applications beyond read assembly.
Further Low Mass Liquid Crystal Systems with Nematic Columnar (Nc) Phase [1] (1992)

Abstract A number of new disc-like pentaynes 1–4 with super-disc cores are presented. These new non-mesogenic electron donors doped with 2,4,7-trinitrofluorenone (5) form charge transfer complexes showing enantiotropic nematic and hexagonal columnar mesophases.
Hydrogen Production from Methane Steam Reforming in Combustion Heat Assisted Novel Microchannel Reactor with Catalytic Stacking (2013)

In this study, we further investigate the application of an MCR containing a nickel metal catalyst with variable number of stacks for hydrogen production via MSR. Microchannels were contained in the MCR one side of the nickel metal catalyst with variable number of stacks for producing hydrogen to generate the necessary heat for the endothermic MSR and the combustion reaction was performed on the other side of the MCR. The catalyst used in this study for the MSR reaction, which was a prepared Pd[0.1]-Al[0.3]/Ni catalyst. The methane conversion and hydrogen production mole ratio were 94.7% and 9.39 mol h–1, respectively, and the steam/carbon (S/C) ratio was 3 at 650 °C, GHSV = 10 000 h–1. The promise of a feasible simplified system for hydrogen production from the MSR was confirmed. If a hydrogen separation membrane is placed between the MSR elements in an MCR, the forward reaction will be preferentially promoted by the rapid removal of the hydrogen produced through the MSR reaction.
On the Pareto Optimality of Ashby's Selection Method for Beams Under Bending (2017)

The paper deals with the problem of choosing the material and the cross section of a beam subjected to bending under structural safety, elastic stability, and available room constraints. An extension of the theory proposed by Ashby is presented. The Pareto-optimal set for the multi-objective problem of stiffness maximization and mass minimization under elastic stability, structural safety, and available room constraints for a beam under bending is derived analytically. The Pareto-optimal set is compared with the solution of the Ashby's selection method.
Hepatitis C Virus RNA Elimination and Development of Resistance in Replicon Cells Treated with BMS-790052 (2012)

BMS-790052, a first-in-class hepatitis C virus (HCV) replication complex inhibitor, targeting nonstructural protein 5A (NS5A), displays picomolar to nanomolar potency against genotypes 1 to 5. This exceptional potency translated into robust anti-HCV activity in clinical studies with HCV genotype 1-infected subjects. To date, all BMS-790052-associated resistance mutations have mapped to the N-terminal region of NS5A. To further characterize the antiviral activity of BMS-790052, HCV replicon elimination and colony formation assays were performed. Replicon was cleared from genotype 1a and 1b replicon cells in a time- and dose-dependent manner. Elimination of the genotype 1a replicon required longer treatment durations and higher concentrations of BMS-790052 than those for the genotype1b replicon. Single amino acid substitutions that conferred relatively low levels of resistance were observed at early time points and at low doses. Higher doses and longer treatment durations yielded mutations that conferred greater levels of resistance, including linked amino acid substitutions. Replicon cells that survived inhibitor treatment remained fully sensitivity to pegylated alpha interferon (pegIFN-α) and other HCV inhibitors. Moreover, genotype 1a replicon elimination was markedly enhanced when pegIFN-α and BMS-790052 were combined. Resistant variants observed in this study were very similar to those observed in a multiple ascending dose (MAD) monotherapy trial of BMS-790052, validating replicon elimination studies as a model to predict clinical resistance. Insights gained from the in vitro anti-HCV activity and resistance profiles of BMS-790052 will be used to help guide the clinical development of this novel HCV inhibitor.
Metabolic engineering of Clostridium autoethanogenum for ethyl acetate production from CO (2022)

Abstract Background Ethyl acetate is a bulk chemical which is traditionally produced via energy intensive chemical esterification. Microbial production of this compound offers promise as a more sustainable alternative. So far, efforts have focused on using sugar-based feedstocks for microbial ester production, but extension to one-carbon substrates, such as CO and CO 2 /H 2 , is desirable. Acetogens such as Clostridium autoethanogenum present a promising microbial platform for biochemical production from one-carbon substrates. Results We engineered C. autoethanogenum to produce ethyl acetate from CO by heterologous expression of an alcohol acetyltransferase (AAT) that catalyzes the formation of ethyl acetate from acetyl-CoA and ethanol. Two AATs, Eat1 and Atf1 were expressed in C. autoethanogenum , and ethyl acetate was successfully produced by strains expressing Atf1. Production of ethyl acetate reached 0.2 mM when grown on CO. Supplementation of ethanol was investigated as potential boost for ethyl acetate production but resulted only in a 1.5-fold increase (0.3 mM ethyl acetate). Besides ethyl acetate, C. autoethanogenum expressing Atf1 could produce 4.5 mM of butyl acetate, when butanol was supplemented to the growth medium. Conclusions This work offers for the first time a proof-of-principle that autotrophic short chain ester production from C1 carbon feedstocks is possible and offers leads on how this approach can be optimized in the future.
Early penetration of the blood‐brain‐barrier by HIV (1988)

One hundred sixty-four patients with chronic progressive multiple sclerosis (MS) have been treated with a regimen of high-dose IV cyclophosphamide and ACTH over the past 6 years. Their status was reviewed to determine complications associated with treatment, dosage of medication used to induce a remission, factors which may predict a response to therapy, and subsequent course following treatment. One year following initial treatment, 81% of patients were improved or stabilized. Reprogression occurred in 69% of patients at a mean time of 17.6 months. Fifty-eight patients who initially stabilized after treatment and then reprogressed were treated a second time. One year after retreatment, 70% of these patients were improved or stabilized. Alopecia, nausea and vomiting, and minor infections were the most frequent complications. There were no deaths associated with treatment, the complication rate did not change with multiple treatments, and no late complications have yet been observed. Improvement tended to occur in younger patients with shorter disease duration. Although this treatment regimen is generally well tolerated and can favorably affect the course of chronic progressive MS in a majority of patients, a single treatment does not induce a permanent remission, and some form of maintenance treatment or retreatment is required. Current treatment programs involve testing a modified induction regimen and periodic outpatient booster injections to maintain remission.
Blind detection of equalization errors in communication systems (1997)

In adaptive channel equalization, transmitted symbol estimates at the equalizer output may be in error because of excessive channel noise, convergence of the equalizer to a "closed-eye" local minimum, or error propagation if the equalizer has a decision feedback structure. This paper is concerned with the detection of equalization errors (i.e., errors in transmitted symbol estimates) in a blindfolded manner whereby no direct access to the channel input is required. The detection problem is cast into a binary hypothesis testing framework. Assuming a linear communication channel that is time-invariant during the test interval, a relationship between the presence of equalization errors and time variations in the underlying linear model taking the transmitted symbol estimates to the equalizer input is established. Based on this relationship, a uniformly most powerful test is constructed to detect the presence of equalization errors in finite-length observations. Finite sample size and asymptotic detection performance of the test is studied. A method for estimating the equalization delay without direct access to the channel input is developed. The effectiveness of the test is illustrated by way of computer simulations.
SOME NOTES ON THE NATURE OF CLAY, II* (1933)

ABSTRACT The drying shrinkage curves were accurately determined for a number of clays Some clays show a secondary shrinkage and Other finely divided The shrink and other finely divided substances. others do not. The latter are generally the less plastic ones. Other finely divided materials beside clay may show considerable plasticity, e.g., ferric oxide. age curves give an insight into the nature of the surface film on the clay particles.
Three‐Dimensional Nonlinear Study of Piles (1991)

The main objective of this work is to examine the effect of nonlinear soil behavior on the axial and lateral response of piles to monotonic and cyclic loading with a view towards developing simplified, yet realistic models for representing pile‐soil‐pile interaction effects. The specific role of pile‐soil slippage and separation, and the overall nonlinear soil behavior on the response of single piles and pairs of piles is studied by means of a three‐dimensional finite element elastoplastic model that includes interface elements for representing slippage and pile‐soil separation. Numerical results indicate that material nonlinearity can significantly affect pile and soil response. Pile‐soil slippage is dominant under purely axial loading, while for lateral loads pile‐soil separation and generalized inelastic soil deformation are the crucial factors. In fact, ignoring these sources of nonlinearity can lead to greatly overestimating the amount of interaction between piles. Guided by the results of this work, a simplified model, consisting of coupled, inelastic supported one‐dimensional piles is developed in the companion paper.
Natürliche Fimbrolide inhibieren Autoinduktorbiosynthese und Luziferaseaktivität und unterdrücken damit die Biolumineszenz in Vibrio (2015)

Abstract Vibrio ist ein Modellorganismus zur molekularen Analyse des Quorum Sensings (QS) und zur Identifikation QS‐interferierender Wirkstoffe. Die natürlichen Fimbrolide sind für die QS‐inhibierenden Wirkungen in verschiedenen Organismen bekannt, allerdings waren die zellulären Angriffspunkte bisher verborgen. Nun ist es gelungen, die irreversiblen Zielstrukturen der Fimbrolide im Proteom von V. harveyi und V. campbellii mithilfe quantitativer Massenspektrometrie und chemisch modifizierter Fimbrolide aufzudecken. Hauptangriffspunkte sind zwei Proteine, die eine essenzielle Rolle für QS und Biolumineszenz in Vibrio spielen. LuxS, das für die Autoinduktor‐2‐Biosynthese verantwortlich ist, und LuxE, eine Untereinheit des Luziferasekomplexes, wurden beide kovalent an Cysteinresten im jeweiligen aktiven Zentrum modifiziert und dadurch inhibiert. Die Identifizierung von LuxE ist in Einklang mit früheren Studien, die die Inhibierung der Biolumineszenz ebenfalls downstream der Signalkaskade vermuteten.
Evaluación de la capacidad protectora de la alfa-cristalina en el endotelio vascular (2001)

El endotelio vascular es un órgano de vital importancia para el mantenimiento de la función circulatoria. Su disfunción se asocia con enfermedades vasculares de alta incidencia. La búsqueda de agentes que reviertan o atenúen los efectos del daño oxidativo sobre el endotelio constituye una prioridad. Se utilizó la línea celular H5V para evaluar el daño producido por el isoprostano iPF2-III, producto de la peroxidación del ácido araquidónico por la acción de los radicales libres, y la capacidad protectora de la a-cristalina frente a esta agresión. La supervivencia de los cultivos celulares se evaluó por el ensayo MTT. Se obtuvo una disminución de la supervivencia en los cultivos tratados con iPF2-III a concentraciones mayores de 300 nmol durante 18 h de exposición. El tratamiento con alfa-cristalina disminuyó el efecto de iPF2-III en 20 %. Este trabajo propuso el efecto de las proteínas de shock término como protectoras endoteliales<br>The vascular endothelium is a vital organ for keeping the circulatory function; its dysfunction is associated with vascular diseases of high incidence. The search for agents that reverse or mitigate the effects of the oxidative damage on the endothelium is a high priority. H5V cell line was used to evaluate the damage caused by iPF2-III isoprostane, a product of the free-radical catalized peroxidation of arachidonic acid, and the alpha crystallin´s protective capacity to this attack. The survival of cell cultures was assessed through the MTT assay. There was reduced survival in cultures treated with iPF2-III isoprostane at concentrations higher than 300 nmol for 18 hrs of exposure. The therapy with alpha crystallin lowered the iPF2-III effect by 20%. This paper showed the effect of heat-shock proteins as endothelial protective agents
On the Aeroelasticity of the Active Span and Passive Pitching Polymorphing Wing: Effect of Morphing Rate (2023)

This paper studies the effect of morphing rate on the aeroelasticity of a polymorphing wing capable of active span extension and passive twist/pitch. A variable domain size finite element model is developed to capture the dynamic effects due to the presence of a variable span in the Euler–Bernoulli beam model, which introduces a structural damping term in the equations of motion. The effect of various morphing rates on the aeroelastic boundaries of the system, namely, flutter velocity and flutter frequency, is examined for a beam undergoing span extension and retraction, from baseline span to 25% span extension and vice versa, respectively. Three points of interest are analyzed: at the start of the span morphing, at the mid-point of morphing, and just before the morphing process ends. The parametric analysis is carried out to determine the effect of varying critical parameters, such as the elastic axis location of the outboard wing section and adjoining spring torsional rigidity on the aeroelastic boundaries of the polymorphing wing.
<title>Future directions in focal-plane signal processing for spaceborne scientific imagers</title> (1991)

The potential of focal-plane signal processing for space-borne scientific imagers is discussed. Significant improvement in image quality and consequent scientific return may be enabled through the utilization of focal-plane signal processing techniques. The possible application of focal-plane signal processing to readout noise reduction, cosmic ray circumvention, non-uniformity correction, and throughput enhancement is described. On-focal-plane analog-to-digital (A/D) conversion and micromotion stabilization are also discussed. It is the intention of this paper to stimulate further thought and efforts in this field.
Access control for the services oriented architecture (2007)

Federated Identity Management (FIdM) is being applied to Services Oriented Architecture (SOA) deployments that cross enterprise boundaries. Though federation is essential in order to address the distributed nature of SOA, these FIdM solutions have been found to be inflexible, unscalable, and difficult to use, manage, and upgrade. We contend that a major reason for these difficulties is that FIdM addresses the wrong aspect of the problem. Specifically, FIdM does not address the federation of access policies. What is needed is a system for Federated Access Management (FAccM). This paper demonstrates the benefits of FAccM over FIdM for SOA deployments and shows how FAccM can be implemented using the existing web services standards.
Ancrage et dépôt de films d'oxydes catalytiques sur des parois métalliques: VOx/TiO2 et Co/SiO2 sur inox (2006)

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