gebhart/patrepeval huggingface dataset:
Design, Synthesis, and Biological Evaluation of New 2-Phenyl-4H-chromen-4-one Derivatives as Selective Cyclooxygenase-2 Inhibitors (2015)

In order to develop new selective COX-2 inhibitors, a new series of 2-phenyl-4H-chromen-4-one derivatives possessing a methylsulfonyl pharmacophore group at the para position of the C-4 phenyl ring were designed, synthesized, and evaluated for cyclooxygenase-2 inhibitory activity. In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4H-chromen-4-one (5d) as a potent COX-2 inhibitor (IC50 = 0.07 μM) with a high COX-2 selectivity index (SI = 287.1) comparable to the reference drug celecoxib (COX-2 IC50 = 0.06 μM; COX-2 SI = 405). A molecular modeling study where 3-(benzyloxy)-2-[4-(methylsulfonyl)phenyl]-4H-chromen-4-one (5d) was docked into the active site of COX-2 showed that the p-MeSO2 substituent on the C-4 phenyl ring was well-oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Val(523), and His(90)) and the carbonyl group of the chromene ring could interact with Ser(530). The structure-activity data acquired indicated that the nature and size of the substituent on the C-3 chromene scaffold are important for COX-2 inhibitory activity. Our results also indicated that the chromene moiety constitutes a suitable template to design new COX-2 inhibitors.
Comparison of Several Methods for Preserving Bacteriophages (1962)

A wide variety of bacteriophages were processed and stored under different conditions to compare methods for long-term preservation. Specimens were stored for 2 years at room temperature (24 to 28 C) and at 4 C as broth lysates in 50% glycerol, dried, and freeze-dried. Titers determined after processing indicated that, of the broth, glycerol, and freeze-dry methods, freeze-drying was most damaging to the phages tested, glycerol less damaging, and the broth method least damaging. After 2 years, titers of broth lysates were generally higher than those of glycerol or freeze-dried preparations. Dried preparations generally did not prove satisfactory. Preparations stored at 4 C showed better titers than those kept at room temperature. All titers declined with time regardless of the conditions of preservation.
Interactive stereoscopic rendering of volumetric environments (2004)

We present an efficient stereoscopic rendering algorithm supporting interactive navigation through large-scale 3D voxel-based environments. In this algorithm, most of the pixel values of the right image are derived from the left image by a fast 3D warping based on a specific stereoscopic projection geometry. An accelerated volumetric ray casting then fills the remaining gaps in the warped right image. Our algorithm has been parallelized on a multiprocessor by employing effective task partitioning schemes and achieved a high cache coherency and load balancing. We also extend our stereoscopic rendering to include view-dependent shading and transparency effects. We have applied our algorithm in two virtual navigation systems, flythrough over terrain and virtual colonoscopy, and reached interactive stereoscopic rendering rates of more than 10 frames per second on a 16-processor SGI Challenge.
Extending land navigation applications to support off road based on elevation and land characteristics (2010)

Most used software tools for land navigation don't have the ability to calculate optimal path outside road network. They show direct Euclidian path from start and goal to nearest road facility. In this paper, we propose an extension for software tools of land navigation to calculate optimal Least Cost Path (LCP) outside road networks using land characteristics and/or digital elevation data (DEM). This extension can be used in off-road navigation by specifying a goal location over map and getting start location from Global Positioning Systems (GPS). Then display the path over a map, current location, and navigation aids. The experimental results of our emulated land navigation system shows that it can be used in real off- road navigation.
Analysis of clinical characteristics, management and survival of patients with Ta T1 bladder tumours in Sweden between 1997 and 2001 (2006)

Our analysis revealed a regional variation in the treatment of bladder cancer. A large group of patients, even those at high risk, were still undertreated. However, the recent publication of guidelines may have contributed to an increased use of intravesical treatment. Urologists tended to treat TaG3 and T1G3 tumours more aggressively than T1G2 tumours. Therapeutic aggressiveness decreased as the age of the patients increased. The survival rate of patients with bladder cancer in Sweden seems to remain at the levels previously reported for the 1980s.
Series-L∕parallel-tuned comparison with shunt-C∕series-tuned class-E power amplifier (2005)

An analysis of the operation of a series-L/parallel-tuned class-E amplifier and its equivalence to the classic shunt-C/series-tuned class-E amplifier are presented. The first reported closed form design equations for the series-L/parallel-tuned topology operating under ideal switching conditions are given. Furthermore, a design procedure is introduced that allows the effect that nonzero switch resistance has on amplifier performance efficiency to be accounted for. The technique developed allows optimal circuit components to be found for a given device series resistance. For a relatively high value of switching device ON series resistance of 4 Ω, drain efficiency of around 66% for the series-L/parallel-tuned topology, and 73% for the shunt-C/series-tuned topology appear to be the theoretical limits. At lower switching device series resistance levels, the efficiency performance of each type are similar, but the series-L/parallel-tuned topology offers some advantages in terms of its potential for MMIC realisation. Theoretical analysis is confirmed by numerical simulation for a 500 mW (27 dBm), 10% bandwidth, 5 V series-L/parallel-tuned, then, shunt-C/series-tuned class E power amplifier, operating at 2.5 GHz, and excellent agreement between theory and simulation results is achieved. The theoretical work presented in the paper should facilitate the design of high-efficiency switched amplifiers at frequencies commensurate with the needs of modern mobile wireless applications in the microwave frequency range, where intrinsically low-output-capacitance MMIC switching devices such as pHEMTs are to be used.
Adaptive recurrent system for noise cancellation and arrhythmia detection (2002)

A new LMS-based adaptive filter for preprocessing and analysis of ECG signals recorded under conditions of stress-tests is introduced. The adaptive filter was developed to cancel motion artifacts and myopotentials and to detect diagnostically significant waves in the ECG signal, e.g. arrhythmias. The new filter exploits a repetitivity of the ECG signal for optimal removing of the nonstationary noise. It uses a vector-variable-step-size LMS algorithm to adjust filter weights according to the nonstationary properties of the processed signal. The developed system was tested on real signals and on the CSE signal library, and the results are described.
EXTENDED QUEST ATTITUDE DETERMINATION FILTERING (1999)

The quaternion estimation (QUEST) batch attitude determination algorithm has been extended to work in a general Kalman-filter framework. This has been done in order to allow the inclusion of a complicated dynamics model and to allow the estimation of additional quantities beyond the attitude quaternion. The QUEST algorithm, which works with vector attitude observations, serves as a starting point because it is able to work with a poor (or no) first guess of the attitude. It is able to do this because its nonlinear estimation problem can be solved exactly by solving an eigenvalue/eigenvector problem. This paper&amp;apos;s extended version of QUEST uses square-root information filtering techniques and linearization of the dynamics to handle all of the non-QUEST parts of the estimation problem. The remaining QUEST-type part of the problem can be solved by a technique that is an extension of the original QUEST algorithm&amp;apos;s eigenvalue/eigenvector solution. The paper shows that two previously-proposed iterative QUEST techniques are special cases of the present algorithm. It also demonstrates the new algorithm&amp;apos;s performance on an attitude determination problem that uses star-tracker and rate-gyro measurements to estimate the attitude time history and the rate-gyro biases. The new algorithm is able to converge from initial attitude errors of 180 o and initial rate-gyro bias errors as large as 2,400 o /hour.
Recent Progress in Organic Electronics:  Materials, Devices, and Processes (2004)

Research in organic electronics has included advances in materials, devices, and processes. Device architectures, increasingly complex circuitry, reliable fabrication methods, and new semiconductors are enabling the incorporation of organic electronic components in products including OLED displays and flexible electronic paper.
The Problem of Henry VIII Reopened: Some Linguistic Criteria for the Two Styles Apparent in the Play. (1951)

Journal Article A. C. Partridge, The Problem of Henry VIII Reopened: Some Linguistic Criteria for the Two Styles Apparent in the Play Get access The Problem of Henry VIII Reopened: Some Linguistic Criteria for the Two Styles Apparent in the Play. By A. C. Partridge with a Foreword by Allardyce Nicoll. Cambridge: Bowes and Bowes, 1949. Pp. 35. 5s. David L. Patrick David L. Patrick University of Arizona Search for other works by this author on: Oxford Academic Google Scholar Shakespeare Quarterly, Volume 2, Issue 2, Spring 1951, Pages 139–141, https://doi.org/10.2307/2866226 Published: 01 April 1951
Recommendations to the European Commission implementing a priority list of additives that should have more stringent reporting requirements: the opinion of the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) (2017)

The European Commission’s Tobacco Products Directive 2014/40/EU (TPD)1 came into force in 2014 and lays out rules governing the manufacture, presentation and sale of tobacco and related products, including cigarettes, roll-your-own tobacco, cigars, cigarillos, smokeless tobacco, electronic cigarettes and herbal products for smoking. It strengthens the rules regarding the reporting on ingredients contained in tobacco products and regulates permissible additives (or levels thereof) to improve the functioning of the internal market while guaranteeing a high level of public health. Articles 6 and 7 specifically focus on additivesi to tobacco products.
Two Efficient Syntheses of Protected 4‐Deoxy‐D‐lyxo‐hexose (4‐Desoxy‐D‐mannose) (2006)

Abstract The formation of four differently protected 4‐deoxy‐D‐lyxo‐hexose derivatives 7, 8, 12, and 14 is described. In the first procedure, a nucleophilic displacement of the allylic mesylate 4 by hydride was combined with a highly stereoselective osmylation of olefin 6 to afford diol 7. In the second radical procedure, tributyl tin hydride was substituted by the cheap and environmentally friendly hypophosphorous acid as a hydrogen donor in the reduction of xanthate 13 to 4‐deoxy lyxo‐hexose 14. Keywords: 4‐Deoxy‐D‐lyxo‐hexoseLiAlH4 reduction of allylic mesylateStereoselective cis‐hydroxylationHypophosphorous acidDeoxygenation Dedicated to Prof. Siegfried Blechert on the occasion of his 60th birthday.
Taking Proof based Verified Computation a Few Steps Closer to Practicality (extended version) (2012)

Abstract. We describe GINGER, a built system for unconditional, general-purpose, and nearly practical verification of outsourced computation. GINGER is based on PEPPER, which uses the PCP theorem and cryptographic techniques to implement an efficient argument system (a kind of interactive protocol). GINGER slashes the query size and costs via theoretical refinements that are of independent interest; broadens the computational model to include (primitive) floating-point fractions, inequality comparisons, logical operations, and conditional control flow; and includes a parallel GPU-based implementation that dramatically reduces latency. 1
Transverse radius dependence for transverse velocity and elliptic flow in intermediate energy HIC (2011)

吝啬的横向的速度和光的椭圆形的流动碎裂(一 2 ) 当横向的半径的一个函数与影响参数为 25 兆电子伏 / 核子 64Cu+64Cu 碰撞被学习由 isospin 依赖的量的 35 fm 分子的动力学模型。由在在里面飞机和 out-of-plane 之间的比较横向的速度，横向的半径上的椭圆形的流动依赖能被理解碎片上的结果的力量的方向的品质上，和变化能被调查品质上。
Taking shape: Street to home programs and initiatives (2011)

The success of Street to Home (STH) services in the USA in helping to address chronic homelessness and reduce the numbers of people sleeping rough has been acknowledged by public policy-makers in Australia who have included the development of these initiatives as a core output in the National Partnership Agreement on Homelessness (NPAH).
Optical and electro-optical properties of II-VI quantum dots (1991)

The paper summarizes recent studies on absorption, luminescence, nonlinear optical effects and electro-absorption on wide-gap II-VI nano-crystals embedded in a glass matrix.
On the Depiction of Figurative Representational Pictures within Pictures (1979)

A special kind of figurative representational picture is a picture containing a depiction of a picture. Using a number of examples, the author considers both the historical and philosophical problems raised by such pictures. He argues that pictures within pictures are best considered ‘quoted’ pictures, and, drawing an analogy with verbal quotations, he offers some suggestions about how to analyze them. He suggests that works by a number of painters can be better understood by seeing what kinds of pictures they choose to ‘quote’. Finally, he discusses a special kind of quoted picture treated in a number of recent texts. These pictures contain what he calls ‘unconscious quotations’. He explains why the notion of such unconscious quotations should be accepted with caution.
Large-Scale Stress Analyses for Fatigue Reliability at Die-Mount Solder of Plastic IC Packages (2009)

In this paper, the influence of the interface debonding area between the molding material and the metal frame on the fatigue reliability at die-mount solder joints in plastic IC packages was studied by means of large-scale finite element analyses. There are several factors causing the interface debonding between the molding material and the metal frame, such as manufacturing process, moisture absorption and deformation under field conditions. The debonding will change the structural stiffness of the packages and deformation shape during a thermal or mechanical load. Therefore, it is a critical issue for fatigue reliability. In this paper, three-dimensional large-scale finite element analysis is used for evaluating the influence of the debonding area on fatigue reliability under thermal cycling. The die-mount solder considered is the high-temperature solder 5Sn/95Pb. which is described by the nonlinear kinematic hardening model of Armstrong and Frederick in the finite element constitutive model. From the result of stress analyses, the debonding area has a large influence on inelastic strain, which is related to fatigue reliability. Large-scale finite element analysis is capable of providing useful guidance for structural design and material selection of plastic IC packages.
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. (1979)

The cloned chromosomal rabbit beta-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20 copies of the cloned globin gene. Rabbit globin transcripts were detected in two of these transformants at steady-state concentrations of 5 and 2 copies per cell. The globin transcripts from one cell line are polyadenylylated and migrate as 9S RNA on methylmercury gels. These transcripts reflect correct processing of the two intervening sequences but lack 48 +/- 5 nucleotides present at the 5' terminus of rabbit erythrocyte globin mRNA.
Impaired secretion and fluid-phase endocytosis in the End4 mutant of Chinese hamster ovary cells (1990)

Mutant V.24.1 defines the End4 complementation group of temperature-sensitive Chinese hamster ovary cell mutants selected for resistance to protein toxins. We investigated the secretory pathway in the mutant cells and found: 1) The hemagglutinin of influenza virus failed to reach the plasma membrane and was retained in a form sensitive to endoglycosidase H at the restrictive temperature. 2) Transferrin receptors synthesized at the restrictive temperature remained sensitive to endoglycosidase H. 3) Secretion of total soluble protein into the medium was strongly reduced at high temperature. These data indicate that V.24.1 cells are defective in secretion at the restrictive temperature. To see what effect the lesion had on the endocytic pathway, we measured the accumulation and recycling of the fluid-phase marker horseradish peroxidase. Accumulation was inhibited by 50% while recycling was barely affected, suggesting that the rate of fluid-phase endocytosis was reduced. We previously showed that the clathrin-coated pit pathway of endocytosis was not affected in the mutant, indicated by a normal transferrin cycle (Colbaugh, P. A., Stookey, M., and Draper, R. K. (1989) J. Cell Biol. 108, 2211-2219). Thus, the secretory lesion correlates with reduced fluid-phase endocytosis without impairing the clathrin-dependent pathway of receptor-mediated endocytosis. We also investigated the delivery of endocytosed material to lysosomes and found that delivery was partially, but not completely, impaired in the mutant. This suggests that endocytosed material can enter lysosomes, although slowly, in the absence of a functional secretory pathway.
Handling Massive Models: Representation, Real-Time Display and Interaction (2008)

Abstract : We propose to address some fundamental research issues in handling and visualizing massive models, composed of millions of primitives. These include efficient representations, interactive display and real-time interaction. These models arise in many applications, including computer-aided design, simulation-based design, lethality and vulnerability analysis, medical simulation, surgical training and scientific visualization. Our goal is to develop efficient algorithms and systems, and demonstrate their performance on massive environments composed of millions of primitives.
Comment on ‘‘Mobility of Ni versus Zr in an amorphous Ni-Zr alloy’’ [Appl. Phys. Lett. 4 8, 517 (1986)] (1986)

Comments are made on Barbour’s paper concerning the mobility and diffusion of Ni and Zr in amorphous Ni−Zr alloys. Specifically, the method of Barbour et al. cannot, in principle, be used to determine which species moves faster. (AIP)
Mechanism of atomization of a liquid jet (1982)

In the atomization regime of a round liquid jet, a diverging spray is observed immediately at the nozzle exit. The mechanism that controls atomization has not yet been determined even though several have been proposed. Experiments are reported with constant liquid pressures from 500 psia (33 atm) to 2500 psia (166 atm) with five different mixtures of water and glycerol into nitrogen, helium, and xenon with gas pressures up to 600 psia (40 atm) at room temperature. Fourteen nozzles were used with length-to-diameter ratios ranging from 85 to 0.5 with sharp and rounded inlets, each with an exit diameter of about 340 μm. An evaluation of proposed jet atomization theories shows that aerodynamic effects, liquid turbulence, jet velocity profile rearrangement effects, and liquid supply pressure oscillations each cannot alone explain the experimental results. However, a mechanism that combines liquid–gas aerodynamic interaction with nozzle geometry effects would be compatible with our measurements but the specific process by which the nozzle geometry influences atomization remains to be identified.
VQAMap: A Novel Mechanism for Mapping Objective Video Quality Metrics to Subjective MOS Scale (2016)

The reliable estimation of video quality has become increasingly important with the proliferation of online video services and users becoming more quality aware. A multitude of objective video quality assessment (VQA) metrics with various performance and complexity have been proposed. However, their applicability in real-world scenarios is limited by the lack of clear interpretations of how the metric values reflect the subjective user-perceived video quality. This paper proposes a novel mechanism called VQAMap, that uses data from public VQA databases and enables to automatically create generic rules for mapping the values of objective VQA metrics to the subjective MOS scale (i.e., 1-bad, 2-poor, 3-fair, 4-good, and 5-excellent). An extensive evaluation study of VQAMap was conducted using data from three public VQA databases, considering six objective VQA metrics. The results analysis has shown that VQAMap provides mapping rules with quality estimation accuracy as high as 95%, while the variation in performance being caused by the varying accuracy of the different objective metrics.
Enhancing Anti-Tumor Activity Against Glioblastoma and Neuroblastoma by Retargeting T Cells with OKT3 X Anti-EGFR (2004)

s for the 19th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer, San Francisco, California, November 4-7, 2004: Adoptive Immunotherapy
Exploring the relationship between selfobject needs and parental bonding (2007)

Self psychology proposes that the individual's early experience is central to adult psychological functioning. The purpose of this paper is to outline the key concepts in self psychology, the empirical evidence supporting it and how it relates to early parenting experiences. The enduring psychological nature of early interactions with an individual's parents, are discussed in relation to adult functioning. Self psychology is based on clinical observations of clients undertaking psychoanalysis. Empirical support for the model is limited. The majority of studies consider the concept of narcissism, and other related self psychological concepts, such as selfobject needs, are inadequate Although this gap in the literature is beginning to be addressed, further work is required. This paper concludes by arguing for the convergence of self psychology and parental bonding theory by integrating concepts from both disciplines in future research. Self psychology is a psychoanalytic theory proposing that other people in an individual's environment provide a psychological function to help them maintain a healthy sense of self. The present study examined the relationship between an individual's childhood bonding experiences with their mother and how they related to others in adulthood. It employed a correlation and regression approach to investigate early parental bonding experiences and later selfobject needs. The Parental Bonding Instrument and the Selfobject Needs Inventory were administered to 264 undergraduate university students at Edith Cowan University. The results indicated that early parental bonding experiences were associated with later selfobject needs. Level of maternal care experienced in childhood was associated with avoidance of idealisation and twinship experiences in adulthood. This study has provided much needed empirical support for the theory of self psychology and given psychologists a greater understanding of the enduring nature of an individual's early parental bonding experiences.
Figure S6 from Identification of an imidazopyridine-based compound as an oral selective estrogen receptor degrader for breast cancer therapy (2023)

&lt;p&gt;X15695 does not induce apoptosis in LNCaP and LAPC-4 cells.&lt;/p&gt;