gebhart/patrepeval huggingface dataset:
Network security, filters and firewalls (1995)

article Free Access Share on Network security, filters and firewalls Author: Darren Bolding View Profile Authors Info & Claims XRDS: Crossroads, The ACM Magazine for StudentsVolume 2Issue 1September 1995 pp 8–10https://doi.org/10.1145/332198.332205Online:01 September 1995Publication History 3citation665DownloadsMetricsTotal Citations3Total Downloads665Last 12 Months23Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Outlook: Further Perspectives of Biophotonics (2006)

This chapter contains sections titled: Future Research Topics Promising Innovative Microscopy Techniques References
miR-31 as a prognostic and predictive marker of disease-free survival (DFS) in resected stage III colon cancer: A retrospective analysis of the PETACC-8 trial (2018)

Background: In RAS wild type metastatic colorectal cancer patients (pts), high tumor expression of microRNA miR-31-3p and miR-31-5p has been associated with poorer benefit of anti-EGFR therapy. miR-31-3p expression has been shown to be predictive of treatment effect in the FIRE-3 trial. The PETACC-8 phase III trial assessed the efficacy of cetux addition to FOLFOX compared to FOLFOX only in pts with resected stage III colon cancer (CC). The primary end point was negative, but a trend towards benefit of cetux on disease free survival (DFS) was observed in pts with RAS/BRAF wild type (WT) tumors. The current study aimed at assessing miR-31-3p and 5p tumor levels as prognostic and predictive biomarkers of adjuvant cetux benefit in these pts. Methods: miR-31-3p and 5p levels were measured by RT-qPCR from 477 WT pts tumor RNA. The primary objective was to demonstrate a benefit of cetux on DFS for low miR-31-3p expressers. Cox regression model was used for univariate and multivariate analyses. Optimal cut-off values for low and high expressers were determined post hoc. Results: In the studied population, cetux benefit was significant for DFS (HR = 0.71 [0.50;1.00] p = 0.05) but not for Overall Survival (OS) (HR = 0.79 [0.53;1.18] p = 0.25). Expression of miR-31-3p and miR-31-5p were highly correlated (R > 0.9). Higher miR-31-3p and 5p expression were associated with shorter DFS and OS (p < 0.01). Pts with low miR-31-3p levels (n = 218/435, 50%) had a non-significant benefit from cetux on DFS (HR 0.61 [0.33; 1.11] p = 0.10) and OS (HR = 0.67 [0.33; 1.35] p = 0.26). Pts with low miR-31-5p levels (n = 233/477, 49%) benefited from cetux on DFS (HR = 0.46 [0.25; 0.84] p = 0.01) and OS (HR = 0.50 [0.25; 0.99], p = 0.047) whereas high expressers did not (DFS: HR = 0.87 [0.56; 1.34] ; OS: HR = 1.01 [0.61; 1.67]). miR-31-5p was predictive of treatment effect on DFS at the 10% level (interaction tests: p = 0.09 for DFS and p = 0.103 for OS). Results were still significant after adjustment for clinical covariates. Conclusions: In pts with resected stage III WT CC, miR-31-3p and 5p were prognostic of DFS and OS. Pts with low miR-31 expression benefited from cetux addition to FOLFOX for adjuvant therapy, and miR-31-5p was predictive of cetux efficacy. Clinical trial identification: NCT03362684. Legal entity responsible for the study: IntegraGen SA. Funding: IntegraGen. Disclosure: Y. Gaston Mathe: Ex employee: IntegraGen. S. Martin-Lannerée, C. Vazart, K. Fontaine: Employee: IntegraGen. A. Caumont, F. Montestruc: Consultant: IntegraGen. J. Taieb: Honoraria: Lilly, Celgene, Servier, Amgen, Roche, Merck, Sirtex, Sanofi. P. Laurent-Puig: Honoraria: IntegraGen, Merck-Serono, Amgen, Boehringer-Ingelheim, Roche, Lilly, Sanofi. All other authors have declared no conflicts of interest.
Influence of concentrated effects on shallow shells (1967)

Fourier transform and theory of generalized functions to obtain differential equilibrium equations to determine concentrated bending and tangential forces on shallow shells
Multifaceted Neuro-Regenerative Activities of Human Dental Pulp Stem Cells for Functional Recovery after Spinal Cord Injury (2014)

Multifaceted Neuro-Regenerative Activities of Human Dental Pulp Stem Cells for Functional Recovery after Spinal Cord Injury
Postmodification of PS-b-P4VP Diblock Copolymer Membranes by ARGET ATRP (2014)

The surfaces of polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) diblock copolymer membranes were modified in order to obtain polymer brushes by using surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP). Isoporous membranes were prepared by the combination of self-assembly of PS-b-P4VP diblock copolymers and the nonsolvent induced phase separation process, also known as "phase inversion". In order to allow further functionalization, the membranes were modified with an ATRP initiator, 2-bromoisobutyryl bromide (BIBB). Therefore, the mussel-inspired poly(dopamine) coating was used to attach BIBB on the membranes surface. In the next step the coated membranes were postmodified by using surface-initiated ARGET ATRP with the hydrophilic monomer 2-hydroxyethyl methacrylate (HEMA). HEMA as a hydrophilic methacrylate was chosen for the modification in order to enhance the membrane characteristics and to obtain a surface with antifouling properties. The surface-initiated ARGET ATRP reaction was carried out using different reaction times and environments. PHEMA could successfully incorporate on the membrane surface as confirmed by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), (1)H nuclear magnetic resonance spectroscopy ((1)H NMR), scanning electron microscopy (SEM), and contact angle measurements. Furthermore, stability tests against heat and solvents were performed, and water flux was measured for the raw and modified membranes. Stability against heat and hydrophilicity could be increased with this type of modification for diblock copolymer membranes.
ChemInform Abstract: Convenient Practical Resolution of Racemic Alkyl‐Aryl Alcohols via Enzymatic Acylation with Succinic Anhydride in Organic Solvents. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ToxicBlend: Virtual Screening of Toxic Compounds with Ensemble\n Predictors (2018)

Timely assessment of compound toxicity is one of the biggest challenges\nfacing the pharmaceutical industry today. A significant proportion of compounds\nidentified as potential leads are ultimately discarded due to the toxicity they\ninduce. In this paper, we propose a novel machine learning approach for the\nprediction of molecular activity on ToxCast targets. We combine extreme\ngradient boosting with fully-connected and graph-convolutional neural network\narchitectures trained on QSAR physical molecular property descriptors, PubChem\nmolecular fingerprints, and SMILES sequences. Our ensemble predictor leverages\nthe strengths of each individual technique, significantly outperforming\nexisting state-of-the art models on the ToxCast and Tox21 toxicity-prediction\ndatasets. We provide free access to molecule toxicity prediction using our\nmodel at http://www.owkin.com/toxicblend.\n
The influence of Plato's developing psychology on his views of rhetoric (1978)

This essay attempts to increase our understanding of Plato's views on rhetoric by associating them with his developing psychology. In his early “Socratic” period, Plato endorsed a “cognitive” psychology; but in his middle period, he adopted a “conflict” psychology. This essay (1) traces the genesis of his conflict psychology, and (2) documents the influence of this genesis on his discussion of rhetoric in the Gorgias and Phaedrus.
A new study on using HTML structures to improve retrieval (2003)

Locating useful information effectively form the World Wide Web (WWW) is of wide interest. This paper presents new results on a methodology of using the structures and hyperlinks of HTML documents to improve the effectiveness of retrieving HTML documents. This methodology partitions the occurrences of terms in a document collection into classes according to the tags in which a particular term appears (such as Title, H1-H6, and Anchor). The rationale is that terms appearing in different structures of a document may have different significance in identifying the document. The weighting schemes of traditional information retrieval were extended to include class importance values. We implemented a genetic algorithm to determine a "best so far" class importance factor combination. Our experiments indicate that using this technique the retrieval effectiveness can be improved by 39.6% or higher.
Parameters for burst detection (2014)

Bursts of action potentials within neurons and throughout networks are believed to serve roles in how neurons handle and store information, both in vivo and in vitro. Accurate detection of burst occurrences and durations are therefore crucial for many studies. A number of algorithms have been proposed to do so, but a standard method has not been adopted. This is due, in part, to many algorithms requiring the adjustment of multiple ad-hoc parameters and further post-hoc criteria in order to produce satisfactory results. Here, we broadly catalog existing approaches and present a new approach requiring the selection of only a single parameter: the number of spikes N comprising the smallest burst to consider. A burst was identified if N spikes occurred in less than T ms, where the threshold T was automatically determined from observing a probability distribution of inter-spike-intervals. Performance was compared vs. different classes of detectors on data gathered from in vitro neuronal networks grown over microelectrode arrays. Our approach offered a number of useful features including: a simple implementation, no need for ad-hoc or post-hoc criteria, and precise assignment of burst boundary time points. Unlike existing approaches, detection was not biased toward larger bursts, allowing identification and analysis of a greater range of neuronal and network dynamics.
Noncontact Sleep Stage Classification Based on Multi-sensor Feature Level Fusion (2019)

This paper presents a new method to realize noncontact sleep stage classification which is based on multi-sensor feature level fusion. The method has be implemented by processing vital signs related to sleep and extracting features from continues wave (CW) Doppler radar sensor and audio sensor. And a novel feature level fusion model is proposed and trained based on machine learning algorithm. Assisting with Polysomnography (PSG) standard sleep stages, the feature level fusion model has achieved high accuracy in noncontact sleep stage classification.
Caratterizzazione dell’epoca di intervento nel diradamento chimico dei frutti di pesco attraverso la misura di alcuni parametri fisiologici delle gemme in dormienza (2004)

La somministrazione di formulati che possano consentire il diradamento chimico delle gemme è necessariamente legata alla scelta dell’epoca di intervento. Questo vale anche e, forse in maggior misura, nel caso in cui vengano utilizzati prodotti diversi (gibberelline, interruttori della dormienza, etilen-promotori) in momenti differenti del ciclo riproduttivo (differenziazione a fiore delle gemme, dormienza invernale, fioritura) impiegando quella che viene definita “strategia ad interventi multipli”. Nel tentativo di definire od individuare con maggiore precisione alcuni parametri fisiologici utili per spiegare la diversa sensibilità delle gemme ai trattamenti con diradanti chimici, è in corso da alcuni anni una ricerca su diverse cultivar di pesco volta a misurare il maggior numero di parametri (biometrici, biochimici e molecolari) nelle fasi finali della dormienza delle gemme. Infatti, sebbene la gemma durante il periodo invernale venga considerata quiescente ed appaia in una fase di crescita stazionaria, sono invece individuabili quattro diversi stadi di accrescimento (S1, S2, S3 e S4) accompagnati da importanti modificazioni che possono influenzare la risposta della pianta al trattamento. In effetti, applicazioni di “interruttori della dormienza”, effettuate in un periodo compreso fra metà gennaio e l’inizio della fioritura, hanno manifestato differenze significative in relazione al diverso accrescimento che caratterizzava la gemma all’epoca dell’intervento. Sulle cultivar esaminate, i trattamenti più efficaci sono sempre risultati quelli effettuati verso la fine di gennaio-primi di febbraio (S1- S2). I parametri misurati, dimensioni, peso fresco e secco, volume, permeabilità delle membrane, contenuto in RNA ed espressione genica (in corso di misurazione), sembrano fornire molte informazioni sulle condizioni fisiologiche delle gemme e, anche se ottenuti con metodiche non sempre di facile applicazione, offrono un quadro più approfondito dello stadio dell’organo al momento dell’applicazione del diradante chimico e sicuramente permetteranno di chiarire la sua diversa efficacia nel tempo.
Some process aspects on single-stage bisulfite pulping of pine (2016)

Sulfite pulping of pine is well-known to be a risky process because problematic lignin conden-sation reactions can occur resulting in poor pulp quality. However, sulfite pulping of pine is interest ...
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity (2008)

Protein misfolding, whether caused by aging, environmental factors, or genetic mutations, is a common basis for neurodegenerative diseases. The misfolding of proteins with abnormally long polyglutamine (polyQ) expansions causes several neurodegenerative disorders, such as Huntington's disease (HD). Although many cellular pathways have been documented to be impaired in HD, the primary triggers of polyQ toxicity remain elusive. We report that yeast cells and neuron-like PC12 cells expressing polyQ-expanded huntingtin (htt) fragments display a surprisingly specific, immediate, and drastic defect in endoplasmic reticulum (ER)-associated degradation (ERAD). We further decipher the mechanistic basis for this defect in ERAD: the entrapment of the essential ERAD proteins Npl4, Ufd1, and p97 by polyQ-expanded htt fragments. In both yeast and mammalian neuron-like cells, overexpression of Npl4 and Ufd1 ameliorates polyQ toxicity. Our results establish that impaired ER protein homeostasis is a broad and highly conserved contributor to polyQ toxicity in yeast, in PC12 cells, and, importantly, in striatal cells expressing full-length polyQ-expanded huntingtin.
Rapid Comparison of Protein Binding Site Surfaces with Property Encoded Shape Distributions (2009)

Patterns in shape and property distributions on the surface of binding sites are often conserved across functional proteins without significant conservation of the underlying amino-acid residues. To explore similarities of these sites from the viewpoint of a ligand, a sequence and fold-independent method was created to rapidly and accurately compare binding sites of proteins represented by property-mapped triangulated Gauss-Connolly surfaces. Within this paradigm, signatures for each binding site surface are produced by calculating their property-encoded shape distributions (PESD), a measure of the probability that a particular property will be at a specific distance to another on the molecular surface. Similarity between the signatures can then be treated as a measure of similarity between binding sites. As postulated, the PESD method rapidly detected high levels of similarity in binding site surface characteristics even in cases where there was very low similarity at the sequence level. In a screening experiment involving each member of the PDBBind 2005 data set as a query against the rest of the set, PESD was able to retrieve a binding site with identical E.C. (Enzyme Commission) numbers as the top match in 79.5% of cases. The ability of the method in detecting similarity in binding sites with low sequence conservations was compared to state-of-the-art binding site comparison methods.
Design Considerations of Efficient Photo-Electrosynthetic Cells and its Realization Using Buried Junction Si Thin Film Multi Absorber Cells (2020)

Abstract As is obvious from previous work on semiconductor photoelectrochemistry, single junction semiconductors do not provide either the required maximum photovoltage or a high photocurrent for solar water splitting, which is required for efficient stand-alone devices. From these experiences we conclude, that multi-junction devices must be developed for bias-free water splitting. In this article we present our design considerations needed for the development of efficient photo-electro-synthetic cells, which have guided us during the DFG priority program 1613. At first, we discuss the fundamental requirements, which must be fulfilled to lead to effective solar water splitting devices. Buried junction and photoelectrochemical arrangements are compared. It will become clear, that the photovoltaic (PV) and electrochemical (EC) components can be optimized separately, but that maximized conversion efficiencies need photovoltages produced in the photovoltaic part of the device, which are adapted to the electrochemical performance of the electrolyzer components without energetic losses in their coupling across the involved interfaces. Therefore, in part 2 we will present the needs to develop appropriate interface engineering layers for proper chemical and electronic surface passivation. In addition, highly efficient electrocatalysts, either for the hydrogen or oxygen evolution reaction (HER, OER), must be adjusted in their energetic coupling to the semiconductor band edges and to the redox potentials in the electrolyte with minimized losses in the chemical potentials. The third part of our paper describes at first the demands and achievements on developing multijunction thin-film silicon solar cells. With different arrangements of silicon stacks a wide range of photovoltages and photocurrents can be provided. These solar cells are applied as photocathodes in integrated directly coupled PV-EC devices. For this purpose thin Pt and Ni catalyst layers are used on top of the solar cells for the HER and a wire connected RuO 2 counter electrode is used for the OER. Electrochemical stability has been successfully tested for up to 10,000 s in 0.1 M KOH. Furthermore, we will illustrate our experimental results on interface engineering strategies using TiO 2 as buffer layer and Pt nanostructures as HER catalyst. Based on the obtained results the observed improvements, but also the still given limitations, can be related to clearly identified non-idealities in surface engineering either related to recombination losses at the semiconductor surface reducing photocurrents or due to not properly-aligned energy states leading to potential losses across the interfaces.
Real-time implementation of lateral flow estimation using spatial quadrature (2002)

The first real-time implementation of lateral flow estimation using spatial quadrature is described and results of its application in flow-phantom experiments presented. Spatial quadrature (SQ) is a recently-introduced technique for two- or three-dimensional flow velocity estimation. In its most basic form, this technique interrogates the region of interest with a pair of point spread functions which have weightings in the lateral dimension with a quadrature relationship. These weightings produce a modulation in the echoes from scatterers moving laterally through a resolution volume. This modulation can be decoded to quantify the lateral velocity component. In this SQ implementation, summed radio-frequency echo data was captured in an M-mode scan geometry using 2:1 parallel processing in spatial quadrature with a 7.5 MHz linear array and a conventional ultrasound scanner. The target for these experiments was a phantom vessel composed of an 8 mm latex tube in a water tank. Using a computer-controlled calibrated flow pump, blood-mimicking fluid was circulated through this vessel at constant volume flow rates of 5-25 ml/s, corresponding to peak flow velocities in the range of 10-45 cm/s. Laminar flow was established in the vessel through the use of a long, straight in-flow tube leading into the vessel. Lateral velocity estimates were subsequently processed off-line to produce velocity profiles over range. These velocity profiles show the parabolic shape characteristic of laminar flow. Volume flow rates were estimated from these profiles using a parabolic curve fit. At optimum pulse repetition frequencies, these SQ-based estimates agreed with the known volume flow to /spl les/5.1% for all flow rates tested.
Monitoring of a bridge with integral abutments (2009)

Preliminary results obtained from short term test-loading are used to illustrate possibilities of FEM used to calibrate complex interaction characteristics between a pile and soil in a bridge with integral abutments. The measurements are obtained during the winter season on the bridge over Leduån, in Northern Sweden. The bridge is built in 2006 and used for long term monitoring within the international project INTAB supported by RFCS. The main objective of the on-going research project is to propose recommendations for rational analysis and design of bridges with integral abutments.
Reciprocal space mapping (1997)

Abstract This review covers the recent advances in reciprocal space mapping. The experimental techniques as well as the theoretical and conceptual developments are discussed. The advantages of reciprocal space mapping over the conventional single scan X-ray scattering methods become clear from the examples presented. Extracting the additional information from mapping in reciprocal space maps has led to a deeper understanding of materials. Imperfect materials benefit enormously from these methods. Near perfect materials also indicate weak diffuse scattering that can now be interpreted in terms of defects, etc., whereas with single scans the influence is difficult to observe and separate from other features. Reciprocal space maps can be collected with both high and low angular resolution diffractometers, depending on the application, although a combination of resolutions may be necessary. It is also growing in importance in the analysis of materials using specular reflectometry. High-resolution reciprocal space mapping is not restricted to good crystalline quality. Examples of reciprocal space mapping are given for semiconductors, metals, ceramics and biological samples. For semiconductor materials, reciprocal space mapping has now become almost routine in the study of lattice relaxation in thin layers and in the assessment of the “quality” of materials. Combinations of mapping with topography and precision lattice parameter determination are also discussed. The latter part of this review discusses the advantages of three-dimensional reciprocal space mapping, which takes the analysis further. With this method the full three-dimensional shapes in reciprocal space can be studied.