gebhart/patrepeval huggingface dataset:
Synthesis of Novel 2-Alkoxy-3-amino-3-arylpropan-1-ols and 5-Alkoxy-4-aryl-1,3-oxazinanes with Antimalarial Activity (2009)

A variety of novel syn-2-alkoxy-3-amino-3-arylpropan-1-ols was prepared through LiAlH(4)-promoted reductive ring-opening of cis-3-alkoxy-4-aryl-beta-lactams in Et(2)O. The latter gamma-aminoalcohols were easily converted into cis-5-alkoxy-4-aryl-1,3-oxazinanes using formaldehyde in THF. Both series of compounds were evaluated against a chloroquine sensitive strain of Plasmodium falciparum (D10), revealing micromolar potency for almost all representatives. Eleven compounds exhibited antimalarial activity with IC(50) values of <or=30 microM, and the majority of these compounds did not show cytotoxicity at the concentrations tested.
ChemInform Abstract: Design and Synthesis of Pfmrk Inhibitors as Potential Antimalarial Agents. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Perfil dos visitantes do Parque Municipal Fazenda Lagoa do Nado na região metropolitana de Belo Horizonte (MG) (2011)

Belo Horizonte (MG), apesar de ser uma das quatro maiores capitais do Brasil, tem o privilegio de contar com 53 parques municipais distribuidos por suas regionais, abrangendo uma area total de 6,8 milhoes de metros quadrados, com grande potencial de agregar qualidade de vida a sua populacao, seja direta ou indireta. O Parque Municipal Fazenda Lagoa do Nado e um destes parques urbanos criado na decada de 80 tendo como proposito aumentar a interacao do homem com areas naturais e tambem de apoiar e difundir a cultura da regiao. Apresenta uma area de 300.000 m2, tratando- se de uma regiao ecotonal entre dois hotpots mundiais: Mata Atlântica e Cerrado. Com o proposito de obter informacoes que otimizem o planejamento do programa de uso publico, efetuou-se um diagnostico do perfil de seus visitantes, atraves da aplicacao de 300 questionarios e entrevistas semi-estruturadas. A amostra contemplou grupos de estudantes, de familias, de amigos e de individuos que foram sozinhos ao parque. Os resultados apontam uma leve predominância de visitantes do sexo masculino, a faixa etaria predominante e de 25 a 45 anos, a maioria dos visitantes vao acompanhados pela familia, somente 20% estavam visitando a area pela primeira vez. A busca de lazer e diversao, a pratica de esportes e a observacao de fauna e flora sao os motivos mais declarados para visitacao, e de um modo geral, as oportunidades vivenciadas apontam para o estreitamento da relacao do homem e a natureza.
Concurrence of superconductivity and structure transition in Weyl semimetal TaP under pressure (2017)

Abstract Weyl semimetal defines a material with three-dimensional Dirac cones, which appear in pair due to the breaking of spatial inversion or time reversal symmetry. Superconductivity is the state of quantum condensation of paired electrons. Turning a Weyl semimetal into superconducting state is very important in having some unprecedented discoveries. In this work, by doing resistive measurements on a recently recognized Weyl semimetal TaP under pressures up to about 100 GPa, we show the concurrence of superconductivity and a structure transition at about 70 GPa. It is found that the superconductivity becomes more pronounced when decreasing pressure and retains when the pressure is completely released. High-pressure x-ray diffraction measurements also confirm the structure phase transition from I 4 1 md to P -6 m 2 at about 70 GPa. More importantly, ab-initial calculations reveal that the P -6 m 2 phase is a new Weyl semimetal phase and has only one set of Weyl points at the same energy level. Our discovery of superconductivity in TaP by high pressure will stimulate investigations on superconductivity and Majorana fermions in Weyl semimetals.
Dominio público: Herramientas multimedia para todas las necesidades (2008)

Existe una autentica Torre de Babel en lo que respecta a los formatos de video, siendo muy frecuentes las preguntas de usuarios sobre que tipo de formato tiene una pelicula que han recibido por correo o que han descargado y con que programa pueden verlo.
Linear and Nonlinear System Identification of a Wave Energy Converter. (2019)

Abstract not provided.
Analytical Strategies for the Determination of Norepinephrine Reuptake Inhibitors in Pharmaceutical Formulations and Biological Fluids (2016)

Norepinephrine reuptake inhibitors (NRIs) are a class of antidepressant drugs that act as reuptake inhibitors for the neurotransmitters norepinephrine and epinephrine. The present review provides an account of analytical methods published in recent years for the determination of NRI drugs. NRIs are atomoxetine, reboxetine, viloxazine and maprotiline. NRIs with less activity at other sites are mazindol, bupropion, tapentadol, and teniloxazine. This review focuses on the analytical methods including chromatographic, spectrophotometric, electroanalytical, and electrophoresis techniques for NRI analysis from pharmaceutical formulations and biological samples. Among all of the published methods, liquid chromatography with UV-vis or MS-MS detection is the most popular technique. The most the common sample preparation techniques in the analytical methods for NRIs include liquid-liquid extraction and solid-phase extraction. Besides the analytical methods for single components, some of the simultaneous determinations are also included in this review.
Remarks on the explicit solutions for nonlinear partially observable stochastic control problems and relations to H/sup ∞/ or robust control (2002)

Partially observable stochastic and H/sup /spl infin// control problems are considered. The dynamics include nonlinearities which are the gradient of some potential function in addition to linear terms, the observations are linear, and the cost functions include quadratic functions and terms related to the nonlinearities in the dynamics. Solutions of the information states for these problems are obtained. These are the analogs of the optimal observer dynamics of linear-exponential-quadratic-Gaussian (LEQG) and linear-quadratic-H/sup /spl infin// (LQH/sup /spl infin//) tracking problems. This enables one to convert the partially observable problems into equivalent completely observable control problems. The optimal control laws for these problems are then shown to be linear feedback equivalent to LEQG and LQH/sup /spl infin// tracking problems. Relations between the two solutions are also investigated.
On the Impact of Imperfect Multipath Detection on the Performance of CDMA Systems with Space-Time Spreading (2005)

We investigate the impact of imperfect multipath detection on the performance of CDMA systems employing space-time spreading. Conventionally, multipath components are detected and assigned to the RAKE fingers based on their average energy content. It is shown that the errors produced by the conventional scheme in detecting the potential multipath components severely impact the performance of the receiver. To boost the performance, we introduce an improved multipath detection scheme based on estimating the interference power in the resolved paths. Our results show that the proposed scheme not only improves the bit error rate performance significantly, but also utilizes the pilot power much more efficiently.
Potential effect of Allium sativum bulb for the treatment of biofilm forming clinical pathogens recovered from periodontal and dental caries (2020)

Biofilm producing clinical bacterial isolates were isolated from periodontal and dental caries samples and identified as, <i>Lactobacillus acidophilus, Streptococcus sanguis</i>, <i>S. salivarius, S. mutans</i>and <i>Staphylococcus aureus</i>. Among the identified bacterial species, <i>S. aureus</i> and <i>S. mutans</i>showed strong biofilm producing capacity. The other isolated bacteria, <i>Streptococcus sanguis</i>, <i>S. salivarius</i> showed moderate biofilm formation. These pathogens were subjected for the production of extracellular polysaccharides (EPS) in nutrient broth medium and the strain <i>S. aureus</i> synthesized more amounts of EPS (610 ± 11.2 µg/ml) than <i>S. sanguis</i> (480 ± 5.8 µg/ml).EPS production was found to be less in <i>S. salivarius</i> (52 ± 3.8 µg/ml).The solvent extract of <i>A. sativum</i> bulb showed the phytochemicals such as, carbohydrate, total protein, alkaloids, saponins, flavonoids, tannins and sterioids. The solvent extract of <i>A. sativum</i> bulb showed wide ranges of activity against the selected dental pathogens. The difference in antibacterial activity of the solvent extract revealed differences in solubility of phytochemicals in organic solvents. Ethanol extract was highly active againstS. aureus (25 ± 2 mm). The Minimum Inhibitory Concentration (MIC) of crude garlic bulb varied widely and this clearly showed that bacteria exhibits different level of susceptibility to secondary metabolites. MIC value ranged between 20 ± 2 mg/ml and 120 ± 6 mg/ml and Minimum Bactericidal Concentration (MBC) value ranged from 60 ± 5 mg/l to 215 ± 7 mg/ml. To conclude, <i>A. sativum</i> bulb can be effectively used to treat periodontal and dental caries infections.
Incidence and characteristics of rhegmatogenous retinal detachment during coronavirus-19 pandemic: A French study (2022)

Despite maintaining accessto emergency eye care facilitiesin our hospital, the lockdown affected visual health. Should the lockdown be reinstated, we postulate that a better information about eye care access for non-Covid emergencies may attenuate its effect on visual health.
Distributed storage with communication costs (2011)

Distributed storage systems provide reliable storage of data by dispersing redundancy across multiple nodes. As the individual nodes are unreliable this protects the integrity of the data against failures. In order to maintain this reliability, new nodes must be introduced into the system whenever nodes are lost which restore the redundancy. This process involves having a new node download information from remaining nodes and is known as the repair problem. In this paper, we consider networks with communication costs associated to each link and explore means to minimize the cost of performing these repairs. We do this by considering a generalized method of repair wherein the amount of information downloaded to a new node varies amongst the other nodes in the network. We find that when nodes store the minimum amount of data that the minimum cost can be achieved by quasi-uniform repair, where the same amount of data is downloaded from each node with which communication takes place. We also consider systems with the additional freedom that the amount of storage is allowed to vary from node to node and look at repair cost minimization there as well.
Extrinsic self calibration of a camera and a 3D laser range finder from natural scenes (2007)

In this paper, we describe a new approach for the extrinsic calibration of a camera with a 3D laser range finder, that can be done on the fly. This approach does not require any calibration object. Only few point correspondences are used, which are manually selected by the user from a scene viewed by the two sensors. The proposed method relies on a novel technique to visualize the range information obtained from a 3D laser scanner. This technique converts the visually ambiguous 3D range information into a 2D map where natural features of a scene are highlighted. We show that by enhancing the features the user can easily find the corresponding points of the camera image points. Therefore, visually identifying laser- camera correspondences becomes as easy as image pairing. Once point correspondences are given, extrinsic calibration is done using the well-known PnP algorithm followed by a noninear refinement process. We show the performance of our approach through experimental results. In these experiments, we will use an omnidirectional camera. The implication of this method is important because it brings 3D computer vision systems out of the laboratory and into practical use.
MicroRNA Expression Ratio Is Predictive of Head and Neck Squamous Cell Carcinoma (2009)

These data suggest that cultured tumor cell lines are inappropriate for microRNA biomarker identification and that the pattern of microRNA expression in primary head and neck tissues is reflective of disease status, with certain microRNAs exhibiting strong predictive potential. These results indicate that miR-221 and miR-375 should be evaluated further as diagnostic biomarkers because they may hold utility in defining broadly responsive prevention and treatment strategies for HNSCC.
Driver fatigue: Electroencephalography and psychological assessment (2002)

Fatigue has major implications for transportation system safety; therefore, investigating the psychophysiological links to fatigue could enhance our understanding and management of fatigue in the transport industry. This study examined the psychophysiological changes that occurred during a driver simulator task in 35 randomly selected subjects. Results showed that significant electroencephalographic changes occur during fatigue. Delta and theta activity were found to increase significantly during fatigue. Heart rate was significantly lower after the driving task. Blink rate also changed during the fatigue task. Increased trait anxiety, tension-anxiety, fatigue-inertia and reduced vigor-activity were shown to be associated with neurophysiological indicators of fatigue such as increased delta and theta activity. The results are discussed in light of directions for future studies and for the development of a fatigue countermeasure device.
Thermal behavior of a two-story concrete building under controlled winter and heat wave scenarios in the sense-city equipment through temperature, flux and energy consumption dataset (2020)

The article describes thermal datasets collected in a two-story concrete building of the Sense-City equipment during various controlled climatic scenarios. Using the Sense-City climatic chamber, we reproduced stationary thermal conditions, a typical winter climate of the south of France and Paris 2003 heat wave. Each of the three scenarios has a duration of about one week. The datasets contain temperature, heat flux and energy consumption sensor outputs. In [1], the stationary conditions data were exploited for an experimental identification of thermal characteristics of the building whereas the winter and the heat wave data were used in a goal-oriented model updating technique. The datasets can also be useful to validate modeling and simulation.
Elevated Serum Levels of Erythropoietin after Xenon Anesthesia in Cardiac Surgery: A Secondary Analysis of a Randomized Controlled Trial (2015)

Objectives: The noble gas xenon has recently been amended to the list of prohibited substances because it is supposed to trigger the production of HIF-1α and subsequently erythropoietin. While any performance-enhancing treatments are strictly prohibited in sport competitions researcher and clinician have opened a debate about the potential transfer of these promising findings into clinical context.
Thiosulfate Production in Cysteine‐Amended Soil (1994)

Abstract Thiol‐labile compounds are produced in cysteine‐amended soil, as evidenced by the production of H 2 S following addition of reagents containing free sulfhydryl groups (−SH). Thiosulfate (S 2 O 2− 3 ) is a likely reactant candidate because it is an intermediate in biogeochemical S cycling and is reduced to H 2 S by ‐SH, but its presence in cysteine‐amended soils has not been documented previously. Four soils were amended with l ‐cysteine (15 mmol kg −1 soil) incubated at 0.033 MPa soil water suction or under saturated conditions, and then extracted with 0.1 M LiCl. Colorimetric analysis of the extracts using cyanolysis with and without addition of a Cu 2+ catalyst indicated the presence of S 2 2− 3 and a polythionate such as S 4 O 2− 6 ; positive interferences from the cyanolysis of S 2− were minimal. Ion chromatographic analysis of the extracts showed a well‐resolved peak with the same retention time as S 2 O 2− 3 and yielded concentration estimates similar to those obtained by colorimetry, providing positive identification of S 2 O 2− 3 in cysteine‐amended soils. Thiosulfate production occurred under both saturated and unsaturated conditions, varied among soils from 0 to 35.2 mg S 2 O 2− 3 ‐S kg −1 , and was nearly eliminated by autoclaving the soil before incubation or by addition of NaN 3 . Although the exact pathway for S 2 O 2− 3 production is unknown, it is likely that H 2 S formation and subsequent oxidation are responsible.
Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications (2014)

The endoplasmic reticulum (ER)-resident protein kinase PERK is a major component of the unfolded protein response (UPR), which promotes the adaptation of cells to various forms of stress. PERK phosphorylates the α subunit of the translation initiation factor eIF2 at serine 51, a modification that plays a key role in the regulation of mRNA translation in stressed cells. Several studies have demonstrated that the PERK-eIF2α phosphorylation pathway maintains insulin biosynthesis and glucose homeostasis, facilitates tumor formation and decreases the efficacy of tumor treatment with chemotherapeutic drugs. Recently, a selective catalytic PERK inhibitor termed GSK2656157 has been developed with anti-tumor properties in mice. Herein, we provide evidence that inhibition of PERK activity by GSK2656157 does not always correlate with inhibition of eIF2α phosphorylation. Also, GSK2656157 does not always mimic the biological effects of the genetic inactivation of PERK. Furthermore, cells treated with GSK2656157 increase eIF2α phosphorylation as a means to compensate for the loss of PERK. Using human tumor cells impaired in eIF2α phosphorylation, we demonstrate that GSK2656157 induces ER stress-mediated death suggesting that the drug acts independent of the inhibition of eIF2α phosphorylation. We conclude that GSK2656157 might be a useful compound to dissect pathways that compensate for the loss of PERK and/or identify PERK pathways that are independent of eIF2α phosphorylation.
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies (2013)

The past decade has witnessed huge advances in our understanding of the genetics underlying Parkinson's disease. Identifying commonalities in the biological function of genes linked to Parkinson's provides an opportunity to elucidate pathways that lead to neuronal degeneration and eventually to disease. We propose that the genetic forms of Parkinson's disease largely associated with α-synuclein-positive neuropathology (SNCA, LRRK2, and GBA) are brought together by involvement in the autophagy/lysosomal pathway and that this represents a unifying pathway to disease in these cases.
Mutations in the signal sequence of prepro-alpha-factor inhibit both translocation into the endoplasmic reticulum and processing by signal peptidase in yeast cells. (1989)

The effects of five single-amino-acid substitution mutations within the signal sequence of yeast prepro-alpha-factor were tested in yeast cells. After short pulse-labelings, virtually all of the alpha-factor precursor proteins from a wild-type gene were glycosylated and processed by signal peptidase. In contrast, the signal sequence mutations resulted in the accumulation of mostly unglycosylated prepro-alpha-factor after a short labeling interval, indicating a defect in translocation of the protein into the endoplasmic reticulum. Confirming this interpretation, unglycosylated mutant prepro-alpha-factor in cell extracts was sensitive to proteinase K and therefore in a cytosolic location. The signal sequence mutations reduced the rate of translocation into the endoplasmic reticulum by as much as 25-fold or more. In at least one case, mutant prepro-alpha-factor molecules were translocated almost entirely posttranslationally. Four of the five mutations also reduced the rate of proteolytic processing by signal peptidase in vivo, even though the signal peptide alterations are not located near the cleavage site. This study demonstrates that a single-amino-acid substitution mutation within a eucaryotic signal peptide can affect both translocation and proteolytic processing in vivo and may indicate that the recognition sequences for translocation and processing overlap within the signal peptide.
In Vivo Biosynthesis of a β-Amino Acid-Containing Protein (2016)

It has recently been reported that ribosomes from erythromycin-resistant Escherichia coli strains, when isolated in S30 extracts and incubated with chemically mis-acylated tRNA, can incorporate certain β-amino acids into full length DHFR in vitro. Here we report that wild-type E. coli EF-Tu and phenylalanyl-tRNA synthetase collaborate with these mutant ribosomes and others to incorporate β(3)-Phe analogs into full length DHFR in vivo. E. coli harboring the most active mutant ribosomes are robust, with a doubling time only 14% longer than wild-type. These results reveal the unexpected tolerance of E. coli and its translation machinery to the β(3)-amino acid backbone and should embolden in vivo selections for orthogonal translational machinery components that incorporate diverse β-amino acids into proteins and peptides. E. coli harboring mutant ribosomes may possess the capacity to incorporate many non-natural, non-α-amino acids into proteins and other sequence-programmed polymeric materials.
Effect of Intraoperative Dexamethasone on Major Complications and Mortality Among Infants Undergoing Cardiac Surgery (2020)

ClinicalTrials.gov Identifier: NCT02615262.
Digital Processing of Ultrasonic Data by Deconvolution (1980)

Abstrocr-Digital deconvolution of ultrasonic echo signals improves resolution and quality of ultrasonic images. Filtering usual B-scan images with a special digital fdter increases the lateral resolution by 50 percent. The filter is constructed from the measured signal amplitudes across the transmitter beam. By an empirical approach, it is optimized for low noise and high resolution. This method for lateral filtering produces good results for a great variety of test objects. The quality of the filter is maintained over a great range of depth, where the original beamwidth varies about 30 percent. This filtering method has high stability, such that application on measured profdes that are heavily disturbed does not increase noise nor produce disturbances.
The Relationship Between Serum Levels of Total IgE, IL‐18, IL‐12, IFN‐γ and Disease Severity in Children With Atopic Dermatitis (2006)

Studies about the role of cytokines on the immunopathogenesis of atopic dermatitis (AD) are generally based on in vitro observations and this role has not been completely clarified yet. Serum levels of total IgE, IL-18, IL-12, IFN-gamma and the relationship between these parameters and disease severity, determined using the SCORAD index, in a group of atopic patients were investigated in this study. Serum levels of total IgE were measured by the nephelometric method and serum levels of IL-18, IL-12/p40 and IFN-gamma were measured by ELISA method. Serum levels of total IgE and IL-18 were found significantly higher in study group than in controls (P<.001). There was no statistically significant difference between patients and controls in respect of serum levels of IL-12/p40 (P = .227). A statistically significant relationship between SCORAD values and serum levels of total IgE (P < .001), IL-18 (P < .001), and IL-12/p40 (P < .001) was determined. These results show that serum levels of IL-18 can be a sensitive parameter that importantly correlates with clinical severity of AD, can play a role in the immunopathogenesis of AD, and furthermore may be used in the diagnosis and follow-up of the disease in addition to other parameters.