gebhart/patrepeval huggingface dataset:
On the Role of Surface Modifications of Palladium Catalysts in the Selective Hydrogenation of Acetylene (2008)

Schwache Bindung, starke Leistung: Nach DFT-Rechnungen erhöhen Legierungsbildung, C-Atome unter der Oberfläche sowie die Hydridbildung die Selektivität von Pd-Katalysatoren für die Acetylenhydrierung durch Schwächung der Oberflächen-Adsorbat-Bindung. Ein einfacher Deskriptor – die Adsorptionsenergie einer Methylgruppe – ermöglicht die Quantifizierung und den Vergleich der Effekte bei der Adsorption von Acetylen und Ethylen an Übergangsmetalloberflächen (siehe Bild).
Endogenous generation and presentation of the ovalbumin peptide/Kb complex to T cells (1993)

Peptide fragments are displayed on the APC surface by MHC class I molecules as ligands for appropriate TCR. Sequence analysis of MHC-bound peptide mixtures has suggested that naturally processed peptides are defined by their length and by the presence of MHC allele-defined consensus motifs. To define the minimal OVA peptide presented by Kb MHC, and the requirements for generation of endogenous OVA/Kb complex, APC were transfected with OVA cDNA constructs. We show that optimal stimulation of OVA/Kb-specific B3Z T cell hybrid by Kb-APC requires the OVA257-264 peptide (SIINFEKL, SL8) whether added exogenously, or when synthesized endogenously as precursor polypeptides. Thus, all information necessary for expression of the OVA/Kb complex is contained within the Kb octapeptide motif shared by SL8. Unexpectedly, the SL8/Kb or the influenza NP/Db complexes were also generated in APC even when the peptide coding sequences were placed in incorrect translational reading frames. By contrast, identical manipulations of the translational reading frame of the lacZ reporter gene reduced protein synthesis to undetectable levels demonstrating the remarkable efficiency with which endogenous peptide/MHC are generated in and presented by APC to T cells. These characteristics of the endogenous presentation may explain how large numbers of distinct peptide/MHC complexes are displayed on the cell surface and surveyed by TCR.
Three-dimensional mixed-wet random pore-scale network modeling of two- and three-phase flow in porous media. I. Model description (2005)

We present a three-dimensional network model to simulate two- and three-phase capillary dominated processes at the pore level. The displacement mechanisms incorporated in the model are based on the physics of multiphase flow observed in micromodel experiments. All the important features of immiscible fluid flow at the pore scale, such as wetting layers, spreading layers of the intermediate-wet phase, hysteresis, and wettability alteration are implemented in the model. Wettability alteration allows any values for the advancing and receding oil-water, gas-water, and gas-oil contact angles to be assigned. Multiple phases can be present in each pore or throat (element), in wetting and spreading layers, as well as occupying the center of the pore space. In all, some 30 different generic fluid configurations for two- and three-phase flow are analyzed. Double displacement and layer formation are implemented as well as direct two-phase displacement and layer collapse events. Every element has a circular, square, or triangular cross section. A random network that represents the pore space in Berea sandstone is used in this study. The model computes relative permeabilities, saturation paths, and capillary pressures for any displacement sequence. A methodology to track a given three-phase saturation path is presented that enables us to compare predicted and measured relative permeabilities on a point-by-point basis. A robust displacement-based clustering algorithm is also presented.
Fluorodeoxyglucose positron emission tomography scans in patients with alcohol use disorder (2022)

Despite widespread metabolic abnormalities, decreases in AUD were most marked in frontal executive areas, consistent with diminished impulse control, and increases were most prominent in the striatum and cingulate areas, consistent with a suppressed reward system.
Traditional Bulgarian Costume Classification in a Tourist Guide application (2020)

Bulgaria is a culturally rich country which has been kept unexplored for years. Modern information and communication technologies can shrink the gap between tourists and its rich historical heritage. A digital tourist guide has been in development that offers its users a tailored experience and guides them through their journey in Bulgaria. Users are able to take a picture of a traditional Bulgarian costume and using various machine learning algorithms the tourist guide is able to recognize it and present interesting information about the photographed object. The following article gives an overview of the tourist guide architecture and image classification process. The authors used a convolutional neural network to classify the uploaded images of traditional Bulgarian costumes. The lack of dataset for training the network is solved by collecting the user-uploaded images, classifying them and using them for improving the classification algorithm automatically. Through this process a lifelong learning has been achieved.
Special issue with contributions from the 11th International IUFRO Wood Drying Conference in Skellefteå, Sweden, January 18–22, 2010 (2010)

In this special issue of Wood Material Science and Engineering, selected and reworked contributions from the 11th International IUFRO Wood Drying Conference in Skelleftea, Sweden, January 18–22, 20...
Optimal Energy Tradeoff Among Communication, Computation and Caching with QoI-Guarantee (2018)

Energy efficiency is a fundamental requirement of modern data communication systems, and its importance is reflected in much recent work on performance analysis of system energy consumption. However, most works have only focused on communication and computation costs, but do not account for caching costs. Given the increasing interest in cache networks, this is a serious limitation. In this paper, we consider the energy consumption trade-off between communication, computation, and caching (C3) under a Quality of Information (QoI) guarantee in a communication network. To attain this goal, we formulate an optimization problem to capture the C3 costs, which turns out to be a non-convex Mixed Integer Non-Linear Programming (MINLP) Problem. We then propose a variant of spatial branch and bound algorithm (V-SBB), that can achieve ε -global optimal solution to the original MINLP. We show numerically that V-SBB is more stable and robust than other candidate MINLP solvers under different network scenarios. More importantly, we observe that the energy efficiency under our C3 optimization framework improves by as much as 88% compared to any C2 optimization between communication and computation or caching.
Impact of urokinase-type plasminogen activator and its inhibitor type 1 on prognosis in cervical cancer of the uterus. (1994)

The present study was undertaken to assess the role of tumor-associated urokinase-type plasminogen activator (uPA) and its inhibitor type 1 (PAI-1) as a predictor for early relapse and poor prognosis in patients with stage II cervical cancer of the uterus. We have investigated the localization of uPA and PAI-1 immunohistochemically in formalin-fixed paraffin-embedded tissue sections. uPA and PAI-1 were analyzed antigenically, enzymologically, and zymographically in 28 patients with pelvic lymph node involvement and in 34 cases without nodal spread, as well as in 10 cases with normal cervix. In cancer tissues, strong staining for uPA was found in areas with invasive growth and degradation of surrounding normal tissue, while most tumor nests showed a mild or a moderate, evenly distributed PAI-1 staining. A significantly higher lymph node-positive rate was observed in patients having tumors with strong uPA and/or PAI-1 stainings than in those with tumors with weak stainings. In spite of significantly higher PAI-1 levels in the primary neoplastic tissues, uPA was found to be increased as well, both in antigen level and in activity. Most of PAI-1 obtained from cancer extracts is the latent form. These results suggest that cancer-associated increase in uPA seems not to be affected (or inhibited) by PAI-1 in areas where tumor cells are invading normal tissue. The overall survival and progression-free survival rate was worst in patients with the strong uPA staining confined to the tumor stromas and also with the strong PAI-1 staining at tumor nests, indicating that the greater localization of uPA in stromal cells than in malignant cells is a predictor of early relapse and poor prognosis in patients with cervical cancer of the uterus. Thus, the staining intensities and the localization of uPA and PAI-1 in tissue specimens appear to be predictors of increasing risk for lymph node metastasis, suggesting that some tumor cells recruit stromal cells to produce uPA and that PAI-1 may not act as a defense mechanism for tumor cell invasion and metastasis in the leading edge of tumor growth.
Direct composite resin restorations of the anterior single tooth: clinical implications and practical applications. (1996)

Modern technology has continued to improve composite resins to the point where they are commonly used in restorative dentistry. In spite of some drawbacks, such as polymerization shrinkage, incomplete conversion and cross-linking, and undesirable water sorption, the expected time of service of these restorations is extended continuously due to physical and chemical improvements. The improved handling and excellent optical properties of the latest generation of composite resins can provide the appearance of natural dentition. Sophisticated effects can be obtained through the use of direct intraoral applications of stratification techniques. This article discusses common indications for direct restoration of anterior teeth and their treatment in order to be biocompatible with the adjacent hard and soft tissues and to meet the requirements of form, function, and phonetics.
Production of long-chain hydroxy fatty acids by Starmerella bombicola (2019)

To decrease our dependency for the diminishing source of fossils resources, bio-based alternatives are being explored for the synthesis of commodity and high-value molecules. One example in this ecological initiative is the microbial production of the biosurfactant sophorolipids by the yeast Starmerella bombicola. Sophorolipids are surface-active molecules mainly used as household and laundry detergents. Because S. bombicola is able to produce high titers of sophorolipids, the yeast is also used to increase the portfolio of lipophilic compounds through strain engineering. Here, the one-step microbial production of hydroxy fatty acids by S. bombicola was accomplished by the selective blockage of three catabolic pathways through metabolic engineering. Successful production of 17.39 g/l (ω-1) linked hydroxy fatty acids was obtained by the successive blockage of the sophorolipid biosynthesis, the β-oxidation and the ω-oxidation pathways. Minor contamination of dicarboxylic acids and fatty aldehydes were successfully removed using flash chromatography. This way, S. bombicola was further expanded into a flexible production platform of economical relevant compounds in the chemical, food and cosmetic industries.
Cardiovascular and Hormonal Aspects of Very‐Low‐Carbohydrate Ketogenic Diets (2004)

In recent years, restriction of carbohydrate intake for weight loss has become widespread. Our research group began studying physiological responses to very-low-carbohydrate ketogenic diets (VLCKDs) in the late 1990s because we felt there was a significant void in the literature and limited understanding of metabolic responses to VLCKDs. This launched us into a line of research examining the physiological effects of VLCKDs. In this paper, we briefly overview nine studies we have published on isoenergetic and hypoenergetic VLCKDs in men and women. These studies have focused on blood lipid responses to VLCKDs, but we have also addressed changes in body weight, body composition, and hormones. Compared with low-fat diets, short-term VLCKDs consistently result in improvements in fat loss, fasting and postprandial triacylglycerols, high-density lipoprotein-cholesterol, the distribution of low-density lipoprotein-cholesterol subclasses, and insulin resistance. These are the key metabolic abnormalities of metabolic syndrome, a problem of epidemic proportions in the United States. There is substantial variability in total cholesterol and low-density lipoprotein-cholesterol responses to VLCKD. The factors responsible for this variability are not known, and studies designed to identify methods to predict blood lipid responses to VLCKD and other dietary approaches represent critical areas for nutrition researchers. Further research is warranted to validate the physiological effects of VLCKD over longer periods of time, including studies that modify the quality of macronutrients (i.e., the type of fat and protein) and the interaction with other interventions (e.g., exercise, dietary supplements, drugs).
Critical Binocular Asymmetry Measure for the Perceptual Quality Assessment of Synthesized Stereo 3D Images in View Synthesis (2015)

In human vision, excessive binocular asymmetry between the left- and right-eye images can be very problematic to perceive single binocular vision (causing visual discomfort) in the viewing of stereoscopic images. In this paper, we propose a critical binocular asymmetry (CBA) measure for objectively assessing the perceptual quality of the synthesized stereo 3D images generated through a depth-image-based rendering (DIBR) process. The proposed method detects critical regions that are likely to induce excessive binocular asymmetry. In particular, this paper considers view extrapolation since it introduces much more artifacts due to the lack of data. We measure structural similarity on the critical regions between the left and right images to quantify the perceptual effects of binocular asymmetry. The effectiveness of the proposed quality measure has been successfully evaluated by subjective assessment experiments using various types of synthesized stereoscopic images generated by four different DIBR-based view synthesis algorithms. We demonstrate the validity of the proposed quality measure by the comparison of subjective ratings and existing objective methods. Experimental results show that the combined use of the proposed binocular asymmetry measure and existing quality measures substantially improves the performance of the quality measures by explicitly considering the perceptual effects of CBA.
Six-minute walk test in or out in evaluation of systemic sclerosis patients? (2017)

In SSc without ILD and PAH, the 6MWD and oxygen desaturation is clinically stable over a 6 months period. The DcSSc subgroup walks less than the LSSc and the LcSSc subgroup.
The Road from Marja: Wounded in Afghanistan, Capt. Erik Quist '99, USMC, sees another side of combat (2012)

Marine Corps Capt. Erik Quist ’99 had fought in two wars. Now he fights again as he recovers from severe wounds suffered in Afghanistan.
Trace level detection and identification of nitro‐based explosives by surface‐enhanced Raman spectroscopy (2013)

Methods for rapid identification of explosives and their associated compounds at trace level quantities are needed for security screening applications. In this paper, we apply the surface‐enhanced Raman spectroscopy (SERS) to detect and identify traces (as low as tens of pg) of pentaerythritol tetranitrate (PETN), ethylene glycol dinitrate (EGDN), cyclotrimethylene‐trinitramine (RDX) and trinitrotoluene (TNT) using commercially available substrates (Klarite®, Renishaw diagnostics). High quality spectra were achieved within 10 s with a compact Raman spectrometer. Principal component analysis (PCA) of the data was performed to understand what factors affected the spectral variation across the samples. It was found that 76% of the spectral variation was explained by the first three PCs. Score plots for these components showed that the energetic materials can be clearly classified on the basis of SERS spectra also at trace level quantity. Our measurements further demonstrate the potential for using SERS as fast, in situ analytical tool for safety devices, with a sensitivity which competes and, in some cases, overcomes other techniques. Copyright © 2013 John Wiley &amp; Sons, Ltd.
Abstract 3649: Targeted sequencing of 409 cancer-related genes for somatic mutations and copy number variations in human cancer using the semiconductor sequencers (2016)

Abstract Next-generation sequencing technologies have revolutionized cancer genomics research by providing a comprehensive method of detecting somatic cancer genome alterations. In this study, we describe a next-generation semiconductor sequencing protocol for rapid (2 days), standardized, and cost-effective gene analysis for human cancer specimens including FFPE samples. DNA was extracted from 19 human cancer cell lines and 61 human cancer specimens and their corresponding non-cancerous tissues, including oral squamous cell carcinomas and multiple myelomas. Using the Ion Ampliseq Comprehensive Cancer Panel, we sequenced 15992 loci from 409 tumor suppressor genes and oncogenes frequently cited and frequently mutated in human cancers (covered regions = 95.4% of total). Each sample underwent on average 8.3 million sequencing reads after quality filtering. The mean read depths were 461x, and &amp;gt;95% of targeted bases were represented by at least 20 reads. We also detected copy number variations in which segments of the genome can be duplicated or deleted from sequencing data. We found several genetic alterations that may have been associated with the poor prognosis and poor response to chemotherapy of cancer patients. Pathway assessment has shown that somatic aberrations within myeloma genomes are mainly involved in several important pathways, including cell cycle regulation, RTK-MAPK-PI3K and NF-kB. This study demonstrates the utility of using a semiconductor-based sequencing to efficiently identify human cancer mutations. The targeted next generation sequencing using low amounts of FFPE DNA is a valuable tool for high-throughput genetic testing in research and clinical settings. Citation Format: Yasushi Sasaki, Ryota Koyama, Takafumi Nakagaki, Miyuki Tamura, Masashi Idogawa, Takashi Tokino. Targeted sequencing of 409 cancer-related genes for somatic mutations and copy number variations in human cancer using the semiconductor sequencers. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3649.
Engage (2012)

Many modern applications are built by combining independently developed packages and services that are distributed over many machines with complex inter-dependencies. The assembly, installation, and management of such applications is hard, and usually performed either manually or by writing customized scripts. We present Engage, a system for configuring, installing, and managing complex application stacks. Engage consists of three components: a domain-specific model to describe component metadata and inter-component dependencies; a constraint-based algorithm that takes a partial installation specification and computes a full installation plan; and a runtime system that co-ordinates the deployment of the application across multiple machines and manages the deployed system. By explicitly modeling configuration metadata and inter-component dependencies, Engage enables static checking of application configurations and automated, constraint-driven, generation of installation plans across multiple machines. This reduces the tedious manual process of application configuration, installation, and management. We have implemented Engage and we have used it to successfully host a number of applications. We describe our experiences in using Engage to manage a generic platform that hosts Django applications in the cloud or on premises.
Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice. (1988)

Efficient transfer of the beta-globin gene into primitive hematopoietic progenitors was achieved with consistent and significant expression in the progeny of those cells. Retroviral vectors containing the intact genomic human beta-globin gene and the neomycin (G418)-resistance (neoR) gene were constructed. These gave titers of 10(6) or more neoR colony-forming units/ml when packaged in psi 2 cells. Mouse bone marrow cells were infected by coculture with producer cells and injected into lethally irradiated animals. Several parameters were varied to enhance infection frequency of colony-forming units, spleen (CFU-S); overall 41% of 116 foci studied contained an intact proviral genome. The human beta-globin gene was expressed in 31 of 35 CFU-S-derived spleen colonies that contained the intact vector genome at levels ranging from 1% to 5% of that of the mouse beta-globin genes. Infected bone marrow cells were also injected into genetically anemic W/Wv recipients without prior irradiation. Human beta-globin chains were detected in circulating erythrocytes by immunofluorescent staining with a specific monoclonal antibody. All animals injected with donor cells that had been cultured in G418 (1 mg/ml) for 48 hr after retroviral infection had circulating erythrocytes containing human beta-globin chains between 3 and 8 weeks after transplantation.
Molecular Detection of Norwalk-Like Caliciviruses in Sewage (1999)

In this study, Norwalk-like virus (NLV) RNA was detected by reverse transcriptase PCR (RT-PCR) in sewage water concentrates. Sequence analysis of the RT-PCR products revealed identical sequences in stools of patients and related sewage samples. In 6 of 11 outbreak-unrelated follow-up samples, multiple NLV genotypes were present. Levels as high as 10(7) RNA-containing particles per liter were found. These data show that high loads of NLVs may be present in sewage and warrant further studies addressing the efficacy of NLV removal by sewage water treatment processes.
Vatten i natur och samhälle : Vattenkvalitet och vattenbeskaffenhet - En probelmöversikt för den TEMA-orienterade forskningsorganisationen vid Linköpings universitet (1979)

Vatten i natur och samhalle : Vattenkvalitet och vattenbeskaffenhet - En probelmoversikt for den TEMA-orienterade forskningsorganisationen vid Linkopings universitet
Understanding the scale of non-adherence with haemodialysis (2017)

Non-adherence significantly impacts patient care and outcomes, and has been associated with increased mortality. In this article, Kelly White and Richard Fluck discuss the results of a recent study into why dialysis sessions were either shortened or cancelled at their unit, and highlight the importance of achieving complete dialysis with every single prescribed session.
A 90 nm 1.8 V 512 Mb Diode-Switch PRAM With 266 MB/s Read Throughput (2008)

A 512 Mb diode-switch PRAM has been developed in a 90 nm CMOS technology. The vertical diode-switch using the SEG technology has achieved minimum cell size and disturbance-free core operation. A core configuration, read/write circuit techniques, and a charge-pump system for the diode-switch PRAM are proposed. The 512 Mb PRAM has achieved read throughput of 266 MB/s through the proposed schemes. The write throughput was 0.54 MB/s in internal x2 write mode, and increased to 4.64 MB/s with x16 accelerated write mode at 1.8 V supply.