gebhart/patrepeval huggingface dataset:
Multiphoton imaging of excised normal skin and keloid scar: preliminary investigations (2004)

Wound healing is a physiologic process that acts to repair disruptions in the continuity of tissue caused by injury or surgical incision. Keloids and hypertrophic scars are forms of aberrant wound healing, which are characterized by the overproduction of collagen, resulting in an excessive amount of scar tissue. Keloid tumors, by definition, grow outside the boundary of the original tissue damage. Multiphoton microscopy (MPM) is an imaging technique which allows imaging of living specimens, without the use of fixation or stains. Images of collagen fibers are produced by the second harmonic signal intensity generated by endogenous fluorescence through excitation by infrared laser light. A postauricular keloid tumor was excised from a patient. The tissue was dissected, and a portion was imaged using MPM. Normal skin tissue was isolated from a patient undergoing a facelift. A portion of this tissue was also dissected and imaged using MPM. MPM images were taken using a 63X water immersion objective lens on a two-photon microscope and a titanium-sapphire laser. Images were taken beginning at the surface of the tissue and moving in at intervals of 200 nm to a final depth of 30 &#956;m. The two-photon images were used to reconstruct three-dimensional representations of the collagen matrix within the tissues, which are readily contrasted. Density of the collagen within each tissue was also ascertained using depth dependant decay of the image intensity. Multiphoton imaging was successfully used to image the collagen matrix of normal skin and a keloid scar, demonstrating differences in their microstructures.
P501 Aspergillus fumigatus complicates one third of the patients with suspected bronchial asthma or pulmonary tuberculosis: Clinical validation of indigenously developed diagnostic kits (2022)

Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Aspergillus fumigatus, an opportunistic fungus, causes complications in about 5%-20% of bronchial asthma and about 26% of pulmonary tuberculosis patients. Detection of Aspergillus fumigatus specific IgG and IgE antibodies in the patient serum is an excellent tool to screen for Aspergillus sensitization early on to employ anti-fungal drugs in the clinical management to stall the progression of lung fibrosis. Methods Novel indigenous AfuPEPLISA assays were developed for the detection of specific IgG and IgE, based on the 12 amino acid long synthetic peptide epitope of Asp f1, an 18 kDa major allergen/antigen. The novel diagnostic kits were manufactured at a licensed GMP facility under a test license. Independent validation of the kits was pursued at PGIMER and VPCI hospitals in suspected bronchial asthma patients (n = 1307), and the diagnostic efficiency was compared with currently used ImmunoCAP assay. Results The diagnostic specificity and sensitivity were found to be 95.7% and 89.8%, respectively, for IgG; and 94.2% and 70%, respectively for IgE AfuPEPLISA, and were not significantly different from ImmunoCAP assay. Screening of the suspected patients of pulmonary tuberculosis (PTB) at RBIPMT Hospital for the presence of A. fumigatus specific IgG and IgE antibodies was pursued using AfuPEPLISA kits. A total of 82 out of 254 suspected PTB patients (32.3%) were seropositive in agreement with the previous reports. See Figures 1 and 2 below. Conclusion The study inferred that indigenously developed AfuPEPLISA kits are an economically viable option to integrate in the clinical management of patients with suspected bronchial asthma or PTB for efficient diagnosis of Aspergillus sensitization.
Analysis of Similar Material in Shaking Table Test (2014)

According to similarity theory, with gypsum, cement, blanc fixe and water as similar material, a study on the relationship of physical and mechanic property and match ratio by orthogonal test. Effect disciplines of elastic modulus and ultimate compressive strength imposed by Content of various materials are worked out. Similar material of this experiment satisfies the requirements of selecting materials well, which therefore is suitable for model experiment.
Forced convection air-cooling of a commercial electronic chassis: an experimental and computational case study (1996)

The present study examines the suitability of a combined experimental and computational methodology for system-level electronic packaging thermal design. A 48.3 cm (19 in), twenty-slot, fully populated commercial-off-the-shelf (COTS) electronic equipment chassis was studied experimentally and computationally. The experimental program involved detailed component surface temperature measurements for system power levels of 423 and 846 W (21 and 42 W/module) and for volumetric flow rates between 0.05 and 0.14 m/sup 3//s. The experimental configuration was also computationally simulated and the predicted component temperatures agreed well with the experiments. The effects of various baffle configuration designs within the inlet plenum were then computationally analyzed for improved thermal performance. The best configuration based on the model study was experimentally examined and provided maximum surface temperature reduction of 56%.
The impact of milk storage temperatures on cheese quality and microbial communities at dairy processing plant scale (2023)

Cheese production is an applied biotechnology whose proper outcome relies strictly on the complex interactive dynamics which unfold within defined microbial groups. These may start being active from the collection of milk and continue up to its final stages of maturation. One of the critical parameters playing a major role is the milk refrigeration temperature before pasteurization as it can affect the proportion of psychrotrophic taxa abundance in the total milk bacterial population. While a standard temperature of 4 °C is the common choice, due to its general growth control effect, it does have a potential drawback. This is due to the fact that some cold-tolerant genera present a proteolytic activity with uncompleted proliferation, which could negatively affect curd clotting and regular cheese maturation. Moreover, accidental thermal variations of milk before cheese-making, in a plus or minus direction, can occur both at farm collection sites and during transfer to dairy plant. This present research, directly commissioned by a major fresh cheese-producing company, includes an in-factory trial. In this trial, a gradient of temperatures from 4 °C to 13 °C, which were subsequently reversed, was purposely adopted to: (a) verify sensory alterations in the resulting product at different maturation stages, and, (b) analyze, in parallel, using DNA extraction and 16S-metabarcoding sequencing from the same samples, the presence, abundance and corresponding taxonomical identity of all the bacteria featured in communities found in milk and cheese samples. Overall, 1,714 different variants were detected and sorted into 394 identified taxa. Significant bacterial community shifts in cheese were observed in response to milk refrigeration temperature and subsequently associated with samples having altered scores in sensory panel tests. In particular, proteolytic psychrotrophes were outcompeted by Enterobacteriales and by other taxa at the peak temperature of 13 °C, but aggressively increased in the descent phases, upon the cooling down of milk to values of 7 °C. Relevant clues have been collected for better anticipation of thermal abuse effects or parameter variations allowing for improved handling of technical processing conditions by the cheese manufacturing industry.
A mathematical model for fluid flow in a weld pool at high currents (1980)

In order to determine the heat transfer inside a TIG (tungsten/inert gas) weld pool, it is necessary to have a good understanding of the flow patterns of the liquid metal. The principal force driving the fluid motion is the electromagnetic j × B force due to the current from the welding arc and its self-magnetic field. In this paper we consider the flow of a viscous incompressible conducting fluid in a hemispherical container due to various distributions of the electric current. The problem is posed as a time-dependent problem and is solved numerically using the Du Fort–Frankel leap-frog method. Results are presented for currents of 100 A flowing through the weld pool. This is a typical current for TIG welding, and corresponds to a Reynolds number in the range 200 &lt; Re &lt; 600. Previous solutions of the problem were restricted to low Reynolds numbers, i.e. low currents.
Kinase Inhibitors (2017)

The strategy of applying kinase inhibitors as effective therapeutic agents has achieved unparalleled success in the past decade, while it is still a daunting challenge to develop kinase inhibitors with desirable selectivity among different kinase families. This chapter describes the basic conceptions in the field of kinase selectivity, available profiling technologies, and quantification of selectivity levels. The chapter highlights the different selectivity of approved kinase inhibitors, which include non-covalent type I and II ATP-competitive inhibitors, allosteric inhibitors, one lipid kinase inhibitor, and covalent inhibitors. Most approved kinase inhibitors are multitarget or unselective inhibitors that bind with the highly conserved ATP pocket, high selectivity is more likely to be achieved among kinases with only few closely related homologs or unique structural features in binding sites.
Anomalous addition of tellurium tetrachloride to allylic esters. Short synthesis of trans-(2S,3S)-2,3-epoxybutane (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnomalous addition of tellurium tetrachloride to allylic esters. Short synthesis of trans-(2S,3S)-2,3-epoxybutaneLars EngmanCite this: J. Am. Chem. Soc. 1984, 106, 14, 3977–3984Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/ja00326a015https://doi.org/10.1021/ja00326a015research-articleACS PublicationsRequest reuse permissionsArticle Views239Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Comparative Study of Similarities in Reality TV and Disaster Films as ‘Fiction’ - Focusing on Its Narrative Structure and Ways to Create Reality (2015)

리얼리티 프로그램은 ‘사실’을 기반으로 하거나 ‘사실적인 느낌을 주는’ 여러 가지 기제들을 활용하여 진정성과 극의 재미를 유발하는 방식으로 대중의 인기를 끌고 있다. 재난영화 또한 현실에서 일어날법한 서사를 차용하여 긴장감과 현실감을 유발한다. 본 연구는 두 장르가 서사구조와 인물 설정, 장르의 관습적 요소와 리얼리티를 유발하는 요소들에 있어서 상당히 유사한 면을 가지고 있음을 분석한다. 리얼리티 프로그램은 현실감을 주기 위한 기제들을 활용, 현실을 재구성하는 ‘유사-리얼리티’ 장르이며, 분류기준에 따라 여러 하위 장르로 나뉜다. 재난영화는 인위적, 자연적 재앙에 맞선다는 기본 서사를 가지고 있으며, 21세기 이후 재난영화들은 현실에서 빈번해진 대형재난들의 서사를 차용, 묵시록적 분위기를 조성하며 리얼리티를 확보한다. 두 장르 모두 ‘안정-불안정-새로운 안정’의 기본 서사 구조를 바탕으로 주인공(영웅 혹은 우승자)과 대립자(이기적인 인물, 무능한 동료, 사악한 권력 혹은 엄격함 심사위원)의 인물구조를 가진다. 장르의 관습적 요소는 위협대상, 플롯위주의 서사구성, 계급구조형성, 도박요소, 고립된 배경, 내부 분열, 로맨스 플롯, 주인공의 전문성 혹은 의외성 등 여덟 가지 항목의 공통점을 보인다. 또한 주인공과 우승자에 가려진 재난희생자와 탈락자의 스펙터클을 어떻게 재현하는가에 대한 문제의식도 동일하게 공유한다. 리얼리티 생성방식에 있어서 두 장르는 당대사회상 반영과 다큐멘터리 요소의 활용, 진정성과 불신의 서사, 일반인 출연, 경쟁 기제의 활용 등 동일한 요소들을 활용한다.
Dynamic topology adaptation of virtual networks of virtual machines (2004)

Virtual machine grid computing greatly simplifies the use of widespread computing resources by lowering the level of abstraction, benefiting both resource providers and users. For the user, the Virtuoso middleware that we are developing closely emulates the existing process of buying, configuring and using machines. VNET, a component of Virtuoso, is a simple and efficient layer two virtual network tool that makes these virtual machines appear to be connected to the home network of the user, simplifying network management. Overlays like VNET have great potential as the mechanism for adaptation. Here, we describe our second generation VNET implementation, which includes support for arbitrary topologies and routing, application topology inference, and adaptive control of the overlay. We demonstrate that the performance of unmodified applications, in particular bulk synchronous parallel applications running inside the virtual machines and serviced by VNET, can be significantly (up to a factor of two) enhanced by adapting the VNET topology and forwarding rules on the fly based on intelligent application traffic inference methods. The adaptation scheme requires no knowledge or participation from the user or application developer.
Multidimensional NMR Spectroscopy of Polymers (1995)

Nuclear Magnetic Resonance (NMR) provides powerful techniques for characterizing molecular and supermolecular properties of polymers. It uses the magnetic and electric interactions of nuclear spins to analyze structure, orientation, and mobility of well-defined chemical moieties. The nuclear magnetic moments are excellent probes that do not affect the state of the system, as NMR energies are only 0.1 kJ/mol or less. Since many polymers are insoluble, or exhibit their most interesting properties in the solid state, NMR research of polymers is dominated by solid-state NMR studies. Nevertheless, solution NMR methods play an important complementary role by determining composition and configuration (1). The following provides a brief introductory overview of the large field of NMR of polymers, including multidimensional techniques. More complete treatments can be found in recent monographs (2-6). Basics of Pulsed NMR The nuclear magnetization (which is proportional the expectation value of the nuclear spin) is aligned with the external
V (2010)

<sc>He</sc> learned what he had asked some three or four days later, after Morris Townsend, with his cousin, had called in Washington Square. Mrs Penniman did not tell her brother, on the drive home, that she had intimated to this agreeable young man, whose...
Architecture of the Whois++ Index Service (1996)

This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the "Internet Official Protocol Standards" (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited.
Process compatibility using high sensitivity resist for KrF excimer laser lithography-ASKA. (1990)

The current state of the art g-line and i-line photolithography using conventional novolac based resists will be able to pattern 0.5-0.6 micron devices adequately, however beyond 0.5 micron, an alternative lithography will be required. KrF excimer laser lithography is one of the leading candidates for sub-half micron VLSI lithography. This technology will be able to take advantage of the higher resolution and wider depth of focus possible with the smaller wavelength. One of the major technical barriers for application of this technology to mass production is the low sensitivity of commercially available resists.
Effect on Ammonium Bromide in dielectric behavior based Alginate Solid Biopolymer electrolytes (2018)

This paper present the development of solid biopolymer electrolytes (SBEs) system which has been accomplished by incorporating various composition of ionic dopant namely ammonium bromide (NH4Br) with alginate solution casting method. The prepared sample of SBEs has been analyzed via electrical impedance spectroscopy (EIS) showed that the ionic conductivity at room temperature was increased from 4.67 x 10-7 S cm-1 for un-doped sample to optimum value at 4.41 x 10-5 S cm-1 for composition of 20 wt. % NH4Br. The SBEs system was found to obey the Arrhenius characteristics with R2~1where all sample is thermally activated when increasing temperature. The dielectric behavior of the alginate-NH4Br SBEs system were measured using complex permittivity (ε*) and complex electrical modulus (M*) and shown the non-debye behavior where no single relaxation was found for present SBEs system.
Feature space video stream consistency estimation for dynamic stream weighting in audio-visual speech recognition (2008)

Most current audio-visual automatic speech recognition (AV- ASR) systems use static weights to leverage between audio and visual information during information fusion. State of the art research has led to using audio reliability metrics for dynamically changing the fusion weights in order to successfully improve overall recognition results. So far, however, incorporating visual reliability metrics into these audio reliability metric based systems have not significantly improved performance. We introduce a new approach to this problem by inferring the "consistency" between the audio and visual information and leveraging the existing audio reliability metrics to create a video reliability metric. Our approach is formulated in the extracted feature space and, thus, does not rely on analyzing the actual video signal itself. The framework presented in this work competes with the audio-only reliability metric based systems and shows promise to consistently outperform.
Brood Affects Hygienic Behavior in the Honey Bee (Hymenoptera: Apidae) (2018)

Despite receiving much attention, the ectoparasitic mite Varroa destructor (Anderson and Trueman) and the pathogens it vectors remain critical threats to the health of the honey bee Apis mellifera (Linnaeus) (Hymenoptera: Apidae). One promising intervention approach is the breeding of hygienic honey bees, which have an improved ability to detect and remove unhealthy brood from the colony, and are thus more resistant to Varroa. While much hygienic behavior-related research has focused on enhanced adult honey bee olfaction, less attention has been paid to the olfactory signals that originate inside the brood cell, triggering hygienic removal. Here, we hypothesized that selection for hygienic behavior in honey bees has influenced brood signaling, predicting that: 1) in a common social environment, removal rates differ among brood with different selective breeding histories, and 2) the removal rates of brood positively correlate to the hygiene level of the brood's colony of origin. To test these predictions, we cross-fostered brood subjected to control, wound, or Varroa treatment in unselected (UNS), Minnesota Hygienic (HYG), and Varroa-Sensitive Hygienic (VSH) colonies, and monitored individual brood cells for hygienic removal. Results confirmed both predictions, as brood from hygienic colonies was more likely to be removed than brood from UNS colonies, regardless of where the brood was fostered. These findings suggest that hygiene-related brood signals complement previously identified characteristics of hygienic adults, constituting an important mechanism of social immunity in honey bees. Thus, selective breeding for honey bee hygienic behavior may be improved through the utilization of field assays containing compounds related to larval signaling.
Passive second-order anti-aliasing filter for RF sampling based receivers (2007)

A second-order FIR anti-aliasing filter for RF sampling receivers is presented. The principle and circuit implementation are detailed for a GSM 900 receiver. The achieved alias rejection is sufficient to meet the specifications without any RF preselect filters.
Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma (2015)

CD70 upregulation by hypoxia-inducible factor and CD27<sup>+</sup> lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene <i>(VHL)</i> mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high soluble CD27 levels in the sera of ccRCC patients suggesting that soluble CD27 is a potential predictive tool for anti-CD70 therapy.
Monitoring the microbiome for food safety and quality using deep shotgun sequencing (2020)

ABSTRACT In this work, we hypothesized that shifts in the food microbiome can be used as an indicator of unexpected contaminants or environmental changes. To test this hypothesis, we sequenced total RNA of 31 high protein powder (HPP) samples of poultry meal pet food ingredients. We developed a microbiome analysis pipeline employing a key eukaryotic matrix filtering step that improved microbe detection specificity to &gt;99.96% during in silico validation. The pipeline identified 119 microbial genera per HPP sample on average with 65 genera present in all samples. The most abundant of these were Bacteroides, Clostridium, Lactococcus, Aeromonas , and Citrobacter. We also observed shifts in the microbial community corresponding to ingredient composition differences. When comparing culture-based results for Salmonella with total RNA sequencing, we found that Salmonella growth did not correlate with multiple sequence analyses. We conclude that microbiome sequencing is useful to characterize complex food microbial communities, while additional work is required for predicting specific species’ viability from total RNA sequencing.
Lipid degradation promotes prostate cancer cell survival (2017)

Prostate cancer is the most common male cancer and androgen receptor (AR) is the major driver of the disease. Here we show that Enoyl-CoA delta isomerase 2 (ECI2) is a novel AR-target that promotes prostate cancer cell survival. Increased ECI2 expression predicts mortality in prostate cancer patients (p = 0.0086). ECI2 encodes for an enzyme involved in lipid metabolism, and we use multiple metabolite profiling platforms and RNA-seq to show that inhibition of ECI2 expression leads to decreased glucose utilization, accumulation of fatty acids and down-regulation of cell cycle related genes. In normal cells, decrease in fatty acid degradation is compensated by increased consumption of glucose, and here we demonstrate that prostate cancer cells are not able to respond to decreased fatty acid degradation. Instead, prostate cancer cells activate incomplete autophagy, which is followed by activation of the cell death response. Finally, we identified a clinically approved compound, perhexiline, which inhibits fatty acid degradation, and replicates the major findings for ECI2 knockdown. This work shows that prostate cancer cells require lipid degradation for survival and identifies a small molecule inhibitor with therapeutic potential.
The Development of a Parallel Ray Launching Algorithm for Wireless Network Planning (2012)

Propagation modeling has attracted much interest because it plays an important role in wireless network planning and optimization. Deterministic approaches such as ray tracing and ray launching have been investigated, however, due to the running time constraint, these approaches are still not widely used. In previous work, an intelligent ray launching algorithm, namely IRLA, has been proposed. The IRLA has proven to be a fast and accurate algorithm and adapts to wireless network planning well. This article focuses on the development of a parallel ray launching algorithm based on the IRLA. Simulations are implemented, and evaluated performance shows that the parallelization greatly shortens the running time. The COST231 Munich scenario is adopted to verify algorithm behavior in real world environments, and observed results show a 5 times increased speedup upon a 16-processor cluster. In addition, the parallelization algorithm can be easily extended to larger scenarios with sufficient physical resources.