gebhart/patrepeval huggingface dataset:
Fundamental Bounds on Transmission Through Periodically Perforated Metal Screens With Experimental Validation (2019)

This article presents a study of transmission through arrays of periodic sub-wavelength apertures. Fundamental limitations for this phenomenon are formulated as a sum rule, relating the transmission coefficient over a bandwidth to the static polarizability. The sum rule is rigorously derived for arbitrary periodic apertures in thin screens. By this sum rule we establish a physical bound on the transmission bandwidth which is verified numerically for a number of aperture array designs. We utilize the sum rule to design and optimize sub-wavelength frequency selective surfaces with a bandwidth close to the physically attainable. Finally, we verify the sum rule and simulations by measurements of an array of horseshoe-shaped slots milled in aluminum foil.
Robust spoken instruction understanding for HRI (2010)

Natural human-robot interaction requires different and more robust models of language understanding (NLU) than non-embodied NLU systems. In particular, architectures are required that (1) process language incrementally in order to be able to provide early backchannel feedback to human speakers; (2) use pragmatic contexts throughout the understanding process to infer missing information; and (3) handle the underspecified, fragmentary, or otherwise ungrammatical utterances that are common in spontaneous speech. In this paper, we describe our attempts at developing an integrated natural language understanding architecture for HRI, and demonstrate its novel capabilities using challenging data collected in human-human interaction experiments.
BMP4 Induces Primitive Endoderm But Not Trophectoderm in Monkey Embryonic Stem Cells (2008)

Monkey embryonic stem (ES) cells share similar characteristics to human ES cells and provide a primate model of allotransplantation, which allows to validate efficacy and safety of cell transplantation therapy in regenerative medicine. Bone morphogenetic protein 4 (BMP4) is known to promote trophoblast differentiation in human ES cells in contrast to mouse ES cells where BMP4 synergistically maintains self-renewal with leukemia inhibitory factor (LIF), which represents a significant difference in signal transduction of self-renewal and differentiation between murine and human ES cells. As the similarity of the differentiation mechanism between monkey and human ES cells is of critical importance for their use as a primate model system, we investigated whether BMP4 induces trophoblast differentiation in monkey ES cells. Interestingly, BMP4 did not induce trophoblast differentiation, but instead induced primitive endoderm differentiation. Prominent downregulation of Sox2, which plays a pivotal role not only in pluripotency but also placenta development, was observed in cells treated with BMP4. In addition, upregulation of Hand1, Cdx2, and chorionic gonadotropin beta (CG-beta), which are markers of trophoblast, was not observed. In contrast, BMP4 induced significant upregulation of Gata6, Gata4, and LamininB1, suggesting differentiation into the primitive endoderm, visceral endoderm, and parietal endoderm, respectively. The threshold of BMP4 activity was estimated as about 10 ng/mL. These findings suggest that BMP4 induced differentiation into the primitive endoderm lineage but not into trophoblast in monkey ES cells.
<title>Design and performance of a charge-coupled device (CCD)-streak tube</title> (1979)

A new &quot;streak&quot; tube has been developed for use in diagnostic applications involving very high-speed optical transients such as the Shiva laser-fusion studies at the University of California&apos;s Lawrence Livermore Laboratory. The tube combines the direct read-out characteristics of a CCD (charge-coupled device) with the high-speed deflection system incorporated in the light-shutter image tube to give immediate electronic read-out of information suitable for data processing. The front section of the tube is an image-intensifier stage with an infrared-sensitive photoc thode (S-1) sensitive to the laser wavelength of 1.06 micrometers. When the laser beam is incident on the photocathode, the emitted stream of electrons is accelerated and deflected by a ramp voltage applied to deflecting electrodes. The deflected beam impacts the CCD, producing several thousand electron-hole pairs per photoelectron. The charge pattern is then scanned out providing a time-intensitv profile of the laser beam.
Fitting Size Distributions to Optical Particle Counter Data (1992)

The theoretical considerations of fitting distributions to aerosol-size spectra derived from optical particle counters are discussed. Based on this, a simple procedure is proposed for fitting the density functions of the commonly used Junge and lognormal distributions, and a special case of the modified gamma distribution. The method uses a generalized linear model to allow for the count statistics of particle sampling.
The activity of recent anti-allergic drugs in the treatment of seasonal allergic rhinitis. (1996)

Two experiments were performed during the pollen season to study the activity of different antiallergic drugs in the treatment of seasonal allergic rhinitis. Nasal allergen challenge (NAC) was performed to mimic an acute attack of allergic rhinitis and to objectively evaluate the effect of the drugs on the early-phase reaction during the season. The first study assessed the effect of H1 (Cetirizine 10 mg a day) and of a combination of H1 (Cetirizine 10 mg) plus H2 (Cimetidine 800 mg a day) antagonists on nasal symptoms, mediator release and eosinophil count in a group of 16 patients with seasonal allergic rhinitis. During the same season a second study compared in a randomized way (2 parallel groups) the effect of Budesonide (Rhinocort Aqua) and Azelastine (Allergodil nasal spray) in a group of 14 patients. Results showed that both antihistamines, applied topically of dosed orally, reduced sneezing even when significant increases of histamine concentration in nasal secretions were evidenced immediately after NAC. When a combination of Cetirizine and Cimetidine was administered, a significant (p < 0.01) reduction of nasal airway resistance and increase of nasal airflow after NAC were demonstrated as well. In addition, topical application of Budesonide showed a strong (p < 0.01) effect on the infiltration and activation of eosinophils during the season, and on tryptase release after NAC. These effects lasted at least for one week after therapy.
¹⁸F-fluorodeoxyglucose-positron emission tomography findings are not related to cognitive functioning in service members with remote history of mild traumatic brain injury. (2022)

After correction for multiple comparisons, there was no significant relationship between regional glucose uptake and neurocognitive performance or cognitive deficits. Glucose uptake as measured by FDG-PET is not indicative of cognitive performance in active duty service members with a remote history of mTBI. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Fatty Acids in Energy Metabolism of the Central Nervous System (2014)

In this review, we analyze the current hypotheses regarding energy metabolism in the neurons and astroglia. Recently, it was shown that up to 20% of the total brain's energy is provided by mitochondrial oxidation of fatty acids. However, the existing hypotheses consider glucose, or its derivative lactate, as the only main energy substrate for the brain. Astroglia metabolically supports the neurons by providing lactate as a substrate for neuronal mitochondria. In addition, a significant amount of neuromediators, glutamate and GABA, is transported into neurons and also serves as substrates for mitochondria. Thus, neuronal mitochondria may simultaneously oxidize several substrates. Astrocytes have to replenish the pool of neuromediators by synthesis de novo, which requires large amounts of energy. In this review, we made an attempt to reconcile β-oxidation of fatty acids by astrocytic mitochondria with the existing hypothesis on regulation of aerobic glycolysis. We suggest that, under condition of neuronal excitation, both metabolic pathways may exist simultaneously. We provide experimental evidence that isolated neuronal mitochondria may oxidize palmitoyl carnitine in the presence of other mitochondrial substrates. We also suggest that variations in the brain mitochondrial metabolic phenotype may be associated with different mtDNA haplogroups.
A distinct variant of intermediate maple syrup urine disease (1985)

Branched chain alpha-ketoacid dehydrogenase (BCKAD) deficiency, or maple syrup urine disease (MSUD), can be categorized as classical, intermediate, intermittent or thiamine responsive, based on generally concordant in vitro BCKAD activity and severity of phenotype. We present clinical and enzymatic data on a boy with intermediate maple syrup urine disease, and suggest that he represents a novel category of mutation. He presented at age 10 months in ketoacidotic coma, with a history of irritability, poor feeding and growth and developmental delay. Branched chain amino acid restriction effected normal growth and developmental parameters by age 42 months. In contrast to previous patients with intermediate MSUD, his fibroblasts and fibroblast extracts failed to decarboxylate [1-14C]-alpha-ketoisovalerate (KIV). The defect is not in mitochondrial transport of substrate, but rather in the catalytic activity of the E1 component of the BCKAD. Disrupted cells of the proband exhibited negligible BCKAD activity over a wide range of keto acid substrate concentrations, irrespective of the presence of added thiamine pyrophosphate (TPP). These results differ from the sigmoidal kinetics observed using classical MSUD extracts, and the hyperbolic kinetics with control preparations under the same assay conditions. We propose that the structurally altered enzyme possesses reduced but not negligible activity in vivo, and exists as an unstable complex in vitro under assay conditions used, even in the presence of added TPP.
Characterization of Volume Gratings Based on Distributed Dielectric Constant Model Using Mueller Matrix Ellipsometry (2019)

Volume grating is a key optical component due to its comprehensive applications. Other than the common grating structures, volume grating is essentially a predesigned refractive index distribution recorded in materials, which raises the challenges of metrology. Although we have demonstrated the potential application of ellipsometry for volume grating characterization, it has been limited due to the absence of general forward model reflecting the refractive index distribution. Herein, we introduced a distributed dielectric constant based rigorous coupled-wave analysis (RCWA) model to interpret the interaction between the incident light and volume grating, with which the Mueller matrix can be calculated. Combining with a regression analysis with the objective to match the measured Mueller matrices with minimum mean square error (MSE), the parameters of the dielectric constant distribution function can be determined. The proposed method has been demonstrated using a series of simulations of measuring the volume gratings with different dielectric constant distribution functions. Further demonstration has been carried out by experimental measurements on volume holographic gratings recorded in the composite of polymer and zinc sulfide (ZnS) nanoparticles. By directly fitting the spatiotemporal concentration of the nanoparticles, the diffusion coefficient has been further evaluated, which is consistent to the result reported in our previous investigations.
Lethal factor VII deficiency due to novel mutations in the F7 promoter: Functional analysis reveals disruption of HNF4 binding site (2012)

Hereditary factor VII (FVII) deficiency is a rare autosomal recessive disorder. Deleterious mutations that prevent the synthesis of any amount of functional FVII have been associated with life-threatening haemorrhage in neonates. Here we report two infants, of Maghrebian origin, who suffered a fatal spontaneous cerebral haemorrhage. Investigation of the molecular basis for their severe FVII deficiency revealed novel mutations in a homozygous state within the F7 gene promoter: a single nucleotide substitution (c.-65G>C) and a 2bp deletion (c.-60_-59delTT). To determine whether these promoter variants were responsible for the FVII deficiency, computer-assisted sequence analyses were performed. The data predicted a disrupted binding of both HNF4 and COUP-TF transcription factors with each variant. Concordantly, experimental results revealed an altered HNF4-induced transactivation in the promoter mutated variants. The execution of functional tests is critical to ensuring a complete understanding of the effect of any promoter mutant on FVII deficiency. Only then can an accurate molecular diagnosis be made and further genetic counselling and prenatal diagnosis be offered.
Climate strategy with CO2 capture from the air (2006)

It is physically possible to capture CO2 directly from the air and immobilize it in geological structures. Air capture differs from conventional mitigation in three key aspects. First, it removes emissions from any part of the economy with equal ease or difficulty, so its cost provides an absolute cap on the cost of mitigation. Second, it permits reduction in concentrations faster than the natural carbon cycle: the effects of irreversibility are thus partly alleviated. Third, because it is weakly coupled to existing energy infrastructure, air capture may offer stronger economies of scale and smaller adjustment costs than the more conventional mitigation technologies. We assess the ultimate physical limits on the amount of energy and land required for air capture and describe two systems that might achieve air capture at prices under 200 and 500 $/tC using current technology. Like geoengineering, air capture limits the cost of a worst-case climate scenario. In an optimal sequential decision framework with uncertainty, existence of air capture decreases the need for near-term precautionary abatement. The long-term effect is the opposite; assuming that marginal costs of mitigation decrease with time while marginal climate change damages increase, then air capture
Existence and computation of infinite horizon model predictive control with active steady-state input constraints (2003)

This note addresses the existence and implementation of the infinite-horizon controller for the case of active steady-state input constraints. This case is important because, in many practical applications, controllers are required to operate at the boundary of the feasible region (for instance, in order to maximize global economic objectives). For this case, the usual finite horizon parameterizations with terminal cost cannot be applied, and optimal solutions are not generally available. We propose here an iterative algorithm that generates two finite-horizon approximations to the true infinite-horizon problem, where the solution to one of the approximations yields an upper bound on the true optimum, while the other approximation yields a lower bound. We show convergence of both bounding approximations to the optimal solution, as the horizon length in the approximations is increased. We outline a procedure, based on this result, to provide a solution to the infinite-horizon problem that is exact to within any user-specified tolerance. Finally, we present an example that includes a comparison between optimal and suboptimal controllers.
A Comparison of Environment Classification Among Premium Hearing Instruments (2021)

Hearing aids classify acoustic environments into multiple, generic classes for the purposes of guiding signal processing. Information about environmental classification is made available to the clinician for fitting, counseling, and troubleshooting purposes. The goal of this study was to better inform scientists and clinicians about the nature of that information by comparing the classification schemes among five premium hearing instruments in a wide range of acoustic scenes including those that vary in signal-to-noise ratio and overall level (dB SPL). Twenty-eight acoustic scenes representing various prototypical environments were presented to five premium devices mounted on an acoustic manikin. Classification measures were recorded from the brand-specific fitting software then recategorized to generic labels to conceal the device company, including (a) Speech in Quiet, (b) Speech in Noise, (c) Noise, and (d) Music. Twelve normal-hearing listeners also classified each scene. The results revealed a variety of similarities and differences among the five devices and the human subjects. Where some devices were highly dependent on input overall level, others were influenced markedly by signal-to-noise ratio. Differences between human and hearing aid classification were evident for several speech and music scenes. Environmental classification is the heart of the signal processing strategy for any given device, providing key input to subsequent decision-making. Comprehensive assessment of environmental classification is essential when considering the cost of signal processing errors, the potential impact for typical wearers, and the information that is available for use by clinicians. The magnitude of differences among devices is remarkable and to be noted.
A motion planner for nonholonomic mobile robots (1994)

This paper considers the problem of motion planning for a car-like robot (i.e., a mobile robot with a nonholonomic constraint whose turning radius is lower-bounded). We present a fast and exact planner for our mobile robot model, based upon recursive subdivision of a collision-free path generated by a lower-level geometric planner that ignores the motion constraints. The resultant trajectory is optimized to give a path that is of near-minimal length in its homotopy class. Our claims of high speed are supported by experimental results for implementations that assume a robot moving amid polygonal obstacles. The completeness and the complexity of the algorithm are proven using an appropriate metric in the configuration space R/sup 2//spl times/S/sup 1/ of the robot. This metric is defined by using the length of the shortest paths in the absence of obstacles as the distance between two configurations. We prove that the new induced topology and the classical one are the same. Although we concentrate upon the car-like robot, the generalization of these techniques leads to new theoretical issues involving sub-Riemannian geometry and to practical results for nonholonomic motion planning.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Changes in Frequency of HIV‐1–Specific Cytotoxic T Cell Precursors and Circulating Effectors after Combination Antiretroviral Therapy in Children (1999)

Combination antiretroviral therapy has had a major role in reducing human immunodeficiency virus type 1 (HIV-1) plasma viral loads in HIV-1-infected adults but a variable effect in infants, in whom complete viral suppression appears to be less readily achieved. In adults, after the reduction in plasma viremia, there is a decrease in the numbers of circulating cytotoxic T cell (CTL) effectors and precursors in the majority of patients. This longitudinal study assessed the effect of combination drug therapy on the frequency of HIV-1-specific CTL responses in 8 HIV-1-infected children. Following treatment, the frequency of HIV-1-specific CTL responses initially increased, especially in children with incomplete viral suppression but with increasing CD4+ cell counts. In children with complete viral suppression, the frequency of HIV-1-specific CTL responses decreased, suggesting that viral replication is required to maintain CTL responses in the systemic circulation.
Fabrication, testing and modeling of a new flexible armor inspired from natural fish scales and osteoderms (2014)

Crocodiles, armadillo, turtles, fish and many other animal species have evolved flexible armored skins in the form of hard scales or osteoderms, which can be described as hard plates of finite size embedded in softer tissues. The individual hard segments provide protection from predators, while the relative motion of these segments provides the flexibility required for efficient locomotion. In this work, we duplicated these broad concepts in a bio-inspired segmented armor. Hexagonal segments of well-defined size and shape were carved within a thin glass plate using laser engraving. The engraved plate was then placed on a soft substrate which simulated soft tissues, and then punctured with a sharp needle mounted on a miniature loading stage. The resistance of our segmented armor was significantly higher when smaller hexagons were used, and our bio-inspired segmented glass displayed an increase in puncture resistance of up to 70% compared to a continuous plate of glass of the same thickness. Detailed structural analyses aided by finite elements revealed that this extraordinary improvement is due to the reduced span of individual segments, which decreases flexural stresses and delays fracture. This effect can however only be achieved if the plates are at least 1000 stiffer than the underlying substrate, which is the case for natural armor systems. Our bio-inspired system also displayed many of the attributes of natural armors: flexible, robust with 'multi-hit' capabilities. This new segmented glass therefore suggests interesting bio-inspired strategies and mechanisms which could be systematically exploited in high-performance flexible armors. This study also provides new insights and a better understanding of the mechanics of natural armors such as scales and osteoderms.
Series Arc Fault Detection Algorithm Based on Autoregressive Bispectrum Analysis (2015)

Arc fault is one of the most critical reasons for electrical fires. Due to the diversity, randomness and concealment of arc faults in low-voltage circuits, it is difficult for general methods to protect all loads from series arc faults. From the analysis of many series arc faults, a large number of high frequency signals generated in circuits are found. These signals are easily affected by Gaussian noise which is difficult to be eliminated as a result of frequency aliasing. Thus, a novel detection algorithm is developed to accurately detect series arc faults in this paper. Initially, an autoregressive model of the mixed high frequency signals is modelled. Then, autoregressive bispectrum analysis is introduced to analyze common series arc fault features. The phase information of arc fault signal is preserved using this method. The influence of Gaussian noise is restrained effectively. Afterwards, several features including characteristic frequency, fluctuation of phase angles, diffused distribution and incremental numbers of bispectrum peaks are extracted for recognizing arc faults. Finally, least squares support vector machine is used to accurately identify series arc faults from the load states based on these frequency features of bispectrum. The validity of the algorithm is experimentally verified obtaining arc fault detection rate above 97%.
3-Naphthyl-4-Quinazolone Infrared and Nuclear Magnetic Resonance Band Assignments (1976)

Abstract The ir and nmr spectra of 24 3-naphthyl-4-quinazolones were examined. There are three principal ir bands in the 1500 and 1705 cm−1 region of the spectra. The first at 1685–1705 cm−1 is assigned to the tertiary amide carbonyl (ArCONR2), the second at 1593–1645 cm−1 to the anil chromophore (ArN=C-N) and the third to the naphthalene ring at 1600 cm−1. The nmr band assignments are straight forward.