gebhart/patrepeval huggingface dataset:
Intracranial Arterial Spasm: A Clinical Analysis (1968)

I T HAS become apparent during the past two decades that patients suffering from spontaneous subarachnoid hemorrhage frequently also have intracranial arterial spasm, a complicating factor that adversely affects their neurological status and prognosis, w-'''~''~,s,~ ~,16'z~ ,9,~3 ~,,,~7 Despite the common occurrence of this phenomenon, its exact etiology and pathogenesis are not known. Intracranial arterial spasm in humans can be induced by mechanical stimuli such as surgical trauma to the cerebral arteries, but the mechanisms that produce preoperative spasm are less well understood. This type of spasm has been found to have the following characteristics: it is seen most frequently in association with subarachnoid hemorrhage; it is usually most marked in the major cerebral arteries ipsilateral to a ruptured aneurysm and involves primarily the parent artery; it is almost exclusively an intradural phenomenon; it usually lasts for days to weeks and does not seem to vary in severity from minute to minute; and it does not appear to be caused by arteriography. Because of these clinical features, as well as the results of various laboratory investigations, 6,14,33,47,51'~7'59 it has been postulated that preoperative intracranial arterial spasm originates locally as a result of arterial distortion and irritation by aneurysmal rupture and perivascular clot formation, and is propagated to other areas by the nerves and smooth muscle fibers of the involved cerebral arteriesY ~ Our recent clinical experience with intracranial arterial spasm, as analyzed in the present paper, adds further support to this concept.
Serum HLA Typing (1981)

This paper establishes that HLA antigens can be detected in serum by lymphocytotoxicity inhibition. A score system is described which enables the degree of cytotoxicity inhibition to be quantitated. The following HLA antigens have been detected: A1, A2, A3, A11, Aw24, B5, B7, B8, B27, Bw35 and B40. It has not been possible to detect HLA-B12.
Extended ellipticity control for attosecond pulses by high harmonic generation (2017)

Attosecond (1 as=10<sup>-18</sup> s) pulses produced through high harmonic generation (HHG) are a basis for studies of electron dynamics during light-matter interaction on an electron's natural time scale. Extensively exploited HHG technology has, however, a few unsolved problems, where producing of circularly polarized or chiral attosecond pulses belongs to them. We have demonstrated experimentally a way to control the ellipticity of attosecond pulse trains produced via HHG in two-color, bi-circular laser fields. We show that the combination of a nonlinear medium position and the intensities of the two-color driving laser fields create an effective helicity-dependent filter. Based on this approach, we report generation of chiral spectra providing potential to produce attosecond pulses with polarization tuned from the rotating, but linear to highly elliptic, with ellipticity as much as ϵ=0.75. This new way to create a chiral-sensitive element offers a simple and practical knob to control polarization for a combined harmonics field in a smooth and predictable manner.
Structural biology of the p53 tumour suppressor (2009)

The p53 tumour suppressor protein has presented a challenge for structural biology for more than two decades. The complete p53 molecule has eluded numerous attempts to determine its structure, presumably owing to the intrinsic conformational flexibility that is essential to the protein's function. Recent data obtained by X-ray crystallography, NMR spectroscopy and electron microscopy provide new insight into the quaternary architecture of the whole molecule and new strategies for examining how these structures correlate with the cell and molecular biology of the 'Guardian of the Genome'.
IVEC (2010)

This paper proposes a unified off-chip memory integrity protection scheme, named IVEC. Today, a system needs two independent mechanisms in order to protect the memory integrity from both physical attacks and random errors. Integrity verification schemes detect malicious tampering of memory while error correcting codes (ECC) detect and correct random errors. IVEC enables both detection of malicious attacks for security and correction of random errors for reliability at the same time by extending the integrity verification techniques. Analytical and experimental studies show that IVEC can correct single-bit errors and even multi-bit errors from one DRAM chip within a cache block read without any additional ECC bits, when the integrity verification is also required for security, effectively removing the memory and bandwidth overheads (12.5%) of typical ECC schemes. Alternatively, with parity bits, IVEC can provide even stronger error correction capabilities comparable to the traditional chip-kill correct, still with less overheads. For both cases, IVEC can use standard non-ECC DIMMs.
Sphingosine 1-phosphate signaling through its receptor S1P 5 promotes chromosome segregation and mitotic progression (2017)

Sphingosine kinase 1 (SphK1) promotes cell proliferation and survival, and its abundance is often increased in tumors. SphK1 produces the signaling lipid sphingosine 1-phosphate (S1P), which activates signaling cascades downstream five G protein-coupled receptors (S1P<sub>1-5</sub>) to modulate vascular and immune system function and promote proliferation. We identified a new function of the SphK1-S1P pathway specifically in the control of mitosis. SphK1 depletion in HeLa cells caused prometaphase arrest, whereas its overexpression or activation accelerated mitosis. Increasing the abundance of S1P promoted mitotic progression, overrode the spindle assembly checkpoint (SAC), and led to chromosome segregation defects. S1P was secreted through the transporter SPNS2 and stimulated mitosis by binding to and activating S1P<sub>5</sub> on the extracellular side, which then activated the intracellular phosphatidylinositol 3-kinase (PI3K)-AKT pathway. Knockdown of S1P<sub>5</sub> prevented the S1P-induced spindle defect phenotype. RNA interference assays revealed that the mitotic kinase Polo-like kinase 1 (PLK1) was an important effector of S1P-S1P<sub>5</sub> signaling-induced mitosis in HeLa cells. Our findings identify an extracellular signal and the downstream pathway that promotes mitotic progression and may indicate potential therapeutic targets to inhibit the proliferation of cancer cells.
Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models (2018)

Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is associated with aging and is a leading cause of blindness worldwide. Here, we demonstrate that leukotriene B4 (LTB4) receptor 1 (BLT1) promotes laser-induced choroidal neovascularization (CNV) in a mouse model for wet-type AMD. CNV was significantly less in BLT1-deficient (BLT1-KO) mice compared with BLT1-WT controls. Expression of several proangiogenic and profibrotic factors was lower in BLT1-KO eyes than in BLT1-WT eyes. LTB4 production in the eyes was substantially increased in the early phase after laser injury. BLT1 was highly expressed in M2 macrophages in vitro and in vivo, and ocular BLT1+ M2 macrophages were increased in the aged eyes after laser injury. Furthermore, M2 macrophages were rapidly attracted by LTB4 and subsequently produced VEGF-A- through BLT1-mediated signaling. Consequently, intravitreal injection of M2 macrophages augmented CNV formation, which was attenuated by BLT1 deficiency. Thus, laser-induced injury to the retina triggered LTB4 production and attracted M2 macrophages via BLT1, leading to development of CNV. A selective BLT1 antagonist (CP105696) and 3 LTB4 inhibitors (zileuton, MK-886, and bestatin) reduced CNV in a dose-dependent manner. CP105696 also inhibited the accumulation of BLT1+ M2 macrophages in the laser-injured eyes of aged mice. Together, these results indicate that the LTB4-BLT1 axis is a potentially novel therapeutic target for CNV of wet-type AMD.
31P-NMR study of cardiac preservation: St. Thomas' Hospital cardioplegic solution versus UW preservation solution (1991)

Ex vivo cardiac preservation was evaluated by measuring the catabolism of high-energy phosphate (ATP and creatine phosphate, CrP) using 31P-NMR spectroscopy. After cardioplegic arrest St. Thomas' Hospital cardioplegic solution (group A), and University of Wisconsin (UW) preservation solution (group B) were tested. The hearts were mounted in the 4.7 T horizontal bore magnet of the NMR spectrometer and were continuously perfused with the test solution under 25 cm H2O pressure for 6 h at 10 degrees C. Peak heights of the beta-phosphate of ATP and CrP were measured and expressed as percentages of the initial value. For both group A and group B. ATP declined less rapidly during preservation than CrP. In group A, ATP remained constant for 60 min while CrP decreased from the onset of preservation. After 6 h of preservation 28.3% of ATP and 24.5% of CrP remained (group A). On the other hand, in group B, levels of both ATP and CrP remained much more stable: CrP did not decrease during the first 3 h of preservation, while ATP started to decrease after 5 h. At the end of preservation 76.1% of ATP and 71.5% of CrP were still present. We conclude that UW solution is superior to St. Thomas' Hospital solution for the preservation of high-energy phosphates during 6 h cardiac preservation with continuous hypothermic low-flow perfusion.
Serum‐derived exosomes from antigen‐fed mice prevent allergic sensitization in a model of allergic asthma (2008)

Oral tolerance is an active process that starts with sampling of luminal antigens by the intestinal epithelial cells (IEC), followed by processing and assembly with major histocompatibility complex class II and subsequently a release of tolerogenic exosomes (tolerosomes) from the IEC. We have previously shown that tolerosomes can be isolated from serum shortly after an antigen feed, and will potently transfer antigen-specific tolerance to naive recipients. Here we study the capacity of the tolerosomes to protect against allergic sensitization in a mouse model of allergic asthma. Serum or isolated serum exosomes from tolerized BALB/c donor mice were transferred to syngeneic recipients followed by sensitization and intranasal exposure to ovalbumin (OVA). Blood, bronchoalveolar lavage (BAL) and lymph nodes were sampled 24 hr after the final exposure. The number of eosinophils was counted in BAL fluid and the levels of immunoglobulin E (IgE) and OVA-specific IgE were measured in serum. Mediastinal and coeliac lymph nodes were analysed by flow cytometry. The animals receiving serum from OVA-fed mice displayed significantly lower numbers of airway eosinophils and lower serum levels of total IgE as well as of OVA-specific IgE compared with controls. Moreover, the tolerant animals showed a significantly higher frequency of activated T cells with a regulatory phenotype in both mediastinal and coeliac lymph nodes. The results show that serum or isolated serum exosomes obtained from OVA-fed mice and administered intraperitoneally to naive recipient mice abrogated allergic sensitization in the recipients.
Theoretical Analysis of Corrosion by Liquid Sodium and Sodium-Potassium Alloys (2008)

Sodium and its alloys such as sodium-potassium (NaK) have been used or considered as coolants in nuclear reactors, including space reactor systems. One potentially serious problem of using a liquid metal/alloy as a coolant is its corrosive effect on its container materials. In the present study, an analytical model has been developed to analyze the corrosion/deposition rates of steels exposed to flowing NaK and Na. In this model, the diffusion of steel constituents in the solid and the transport of the corrosion products in the liquid are coupled at the liquid/solid interface. The model can be used to predict the steel constituent distributions in the corrosion layer as well as recession of the solid walls. Both isothermal and non-isothermal cases are considered. It is expected that the theoretical model can serve as a tool for structure material selection and for the design of the structural components in a liquid metal reactor.
Stable Adaptive Estimation for Speed-sensorless Induction Motor Drives: A Geometric Approach (2020)

Rotor speed estimation is one of the key problems in speed-sensorless motor drives. Adaptation-based approaches, assuming the rotor speed as a parameter and based on the original coordinates, admit simple estimator designs, albeit suffer from the lack of guaranteed convergence of estimation error dynamics. Focusing on stable speed estimation, this paper proposes a new algorithm based on transforming the motor model into an adaptive observer form via a change of state coordinates. The resultant adaptive estimator renders globally exponentially convergent estimation error dynamics, under persistent excitation condition, which is analogous to entail a time-varying rotor flux. The proposed algorithm is advantageous for its guaranteed stability, ease of tuning, and robustness. Experiments demonstrate its effectiveness in mid-/high-speed operation regions.
The C-ErbAβ Thyroid Hormone Receptor Expression and cDNA sequence analysis of the hormone-binding domain in human cancer cell lines (1994)

The human c-erbA beta protooncogene encodes a thyroid hormone receptor (comprising a hormone-binding domain and a DNA-binding domain) which modulates expression of specific genes, such as cell differentiation genes. Using the reverse transcription and polymerase chain reaction (RT-PCR) assay, significant expression of the c-erbA beta gene was detected in the SiHa, CaSki, HeLa cervical carcinoma; Hep3B, PLC/PRF/5, Mahlavu hepatocellular carcinoma; HT-1080 fibrosarcoma cell lines; as well as in normal MRC-5 embryo lung and FS-4 foreskin fibroblast cell lines. However, the Molt-4 leukaemia and Raji Burkitt's lymphoma cell lines exhibited very low levels of c-erbA beta expression. Single-strand conformation polymorphism analysis and direct sequencing of PCR products of the c-erbA beta hormone-binding domain cDNAs of these cell lines revealed identical sequences, but differed from the published human placental c-erbA beta sequence by five single base disparities. Sequencing of an aberrant fragment fortuitously amplified from the HT-1080 cDNA library demonstrated concordance with the cDNA of pregnancy-specific glycoprotein 4, which is related to the tumour marker, carcinoembryonic antigen.
Energetic Polyoxetane Thermoplastic Elastomers: Synthesis and Characterization (1988)

This report summarizes our work at the Naval Weapons Center developing improved polymeric binders for energetic materials during Fiscal Year 1987.
Effects of Nickel and Iron Oxide Addition by Milling under Hydrogen on the Hydrogen-Storage Characteristics of Mg-Based Alloys (2012)

Samples of pure Mg, 76.5 wt%Mg-23.5 wt%Ni, and 71.5 wt%Mg-23.5 wt%Ni-5 wt%Fe2O3 were prepared by reactive mechanical grinding and their hydriding and dehydriding properties were then investigated. The reactive mechanical grinding of Mg with Ni is considered to facilitate nucleation and to shorten diffusion distances of hydrogen atoms. After hydriding-dehydriding cycling, the 76.5 wt%Mg- 23.5 wt%Ni and 71.5 wt%Mg-23.5 wt%Ni-5 wt%Fe2O3 samples contained Mg2Ni phase. In addition to the effects of the creation of defects and the decrease in particle size, the addition of Ni increases the hydriding and dehydriding rates by the formation of Mg2Ni. Expansion and contraction of the hydride-forming materials (Mg and Mg2Ni) with the hydriding and dehydriding reactions are also considered to increase the hydriding and dehydriding rates of the mixture by forming defects and cracks leading to the fragmentation of particles. The reactive mechanical grinding of Mg-Ni alloy with Fe2O3 is considered to decrease the particle size.
Novel Type of Phase Transition in a System of Self-Driven Particles (1995)

A simple model with a novel type of dynamics is introduced in order to investigate the emergence of self-ordered motion in systems of particles with biologically motivated interaction. In our model particles are driven with a constant absolute velocity and at each time step assume the average direction of motion of the particles in their neighborhood with some random perturbation $(\ensuremath{\eta})$ added. We present numerical evidence that this model results in a kinetic phase transition from no transport (zero average velocity, $|{\mathbf{v}}_{a}|\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0$) to finite net transport through spontaneous symmetry breaking of the rotational symmetry. The transition is continuous, since $|{\mathbf{v}}_{a}|$ is found to scale as $({\ensuremath{\eta}}_{c}\ensuremath{-}\ensuremath{\eta}{)}^{\ensuremath{\beta}}$ with $\ensuremath{\beta}\ensuremath{\simeq}0.45$.
LDPC-like belief propagation algorithm for consensus building in wireless sensor networks (2009)

In this paper, we apply belief propagation algorithm for consensus building in distributed wireless sensor networks (WSN). The objective is to achieve convergence to a global consensus value at all sensor nodes in the network. In order to implement the proposed belief propagation algorithm in a WSN, we introduce virtual fusion center nodes, which serve as sensors as well as local fusion centers in the sensor network. This paper also investigates the structure of WSNs that achieves convergence asymptotically, and guarantees achieving global consensus at all sensor nodes. Our results suggest that introducing certain range of irregularity in the network structure results in an improvement in the rate of convergence.
Dementia and hearing-aid use: a two-way street (2021)

Abstract Objectives Hearing-aid use may reduce risk of dementia, but cognitive impairment makes hearing-aid use more challenging. These two causal pathways may both manifest as an association between reduced hearing-aid use and incident dementia. This study examined the effects of each pathway separately, through a unique combination of longitudinal data regarding hearing, general health, dementia diagnoses and continuity of HA use. Methods Longitudinal health records data from 380,794 Veterans who obtained hearing aids from the US Veterans Affairs healthcare system were analysed. Analysis 1 (n=72,180) used logistic regression to model the likelihood of a dementia diagnosis at 3 year 6 months (3y6m) to 5 years post hearing-aid fitting for patients previously free of dementia and mild cognitive impairment (MCI). Analysis 2 (n=350,918) modelled the likelihood of being a persistent hearing aid user at 3y2m after fitting, contrasting sub-groups with differing levels of cognitive function at the time of fitting. Models controlled for relevant predictors available in the dataset. Results In analysis 1, the adjusted OR for incident dementia was 0.73 (ci 0.66-0.81) for persistent (vs. non persistent) hearing-aid users. In analysis 2, the adjusted OR for hearing-aid use persistence was 0.46 (ci 0.43-0.48) in those with pre-existing dementia (vs. those remaining free of MCI and dementia). Conclusion The results indicate substantial effects from both causal pathways. Research studying protective effects of hearing-aid use against dementia needs to account for this. Clinically, hearing devices and hearing care processes must be accessible and usable for all, regardless of their level of cognitive function.
重金属汚染土壌から汚染物質を回収する高機能環境修復植物の探索(2004-2005年度神奈川大学共同研究奨励助成論文) : ケナフによるカドミウム除染の可能性 (2006)

Kenaf (Hibiscus cannabinus L.), which can grow rapidly and maintain high primary production, was examined for its ability to decontaminate cadmium ions (Cd) from polluted soil. Although its germination and growth were not affected at first, its photosynthesis dependent growth was disturbed by Cd in the soil. No growth after expanding the true leaves was observed at above 111ppm Cd. At 74.1ppm Cd, kenaf could acclimate and began to grow after a few weeks lag. The biomass increased by 2.4 times from 4 to 6 weeks after sawing. Higher accumulation rates were observed in the plant body at below 74.1ppm Cd. The rate increased to 6.4 times in the plant body at 1.48ppm Cd. Assuming the same productions of kenaf as on the soil without Cd, it could decontaminate 1.48ppm Cd from the polluted soil for ca. 16 years and could more efficiently from the soil containing lower concentrations of Cd. These results suggested the possible phytoremediation with kenaf applied to the polluted soil with lower concentrations of Cd.
An improved partial CSIT random beamforming for multibeam satellite systems (2008)

A novel multiple input multiple output (MIMO) transmitting scheme is presented for multibeam satellite systems, where the objective is to increase the system sum rate, availability and variance performance.
Automated Inspection of Char Morphologies in Colombian Coals Using Image Analysis (2020)

Precise automated determination of char morphologies formed by coal during combustion can lead to more efficient industrial control systems for coal combustion. Commonly, char particles are manually classified following the ICCP decision tree which considers four morphological features. One of these features is unfused material, and this class of material not characteristic of Colombian coals. In this paper, we propose new machine learning algorithms to classify the char particles in an image based system. Our hypothesis is that supervised classification methods can outperform the 4 ‘class’ ICCP criteria. In this paper we evaluate several morphological features and specifically assess the contribution of the unfused material feature on the overall classification performance. The results from this work confirm that the proposed method is able to accurately identify and automatically classify chars.
A Proposed Mechanism of the Alkylation of Benzyl Halides with Nitro Paraffin Salts (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Proposed Mechanism of the Alkylation of Benzyl Halides with Nitro Paraffin SaltsH. B. Hass and Myron L. BenderCite this: J. Am. Chem. Soc. 1949, 71, 10, 3482–3485Publication Date (Print):October 1, 1949Publication History Published online1 May 2002Published inissue 1 October 1949https://pubs.acs.org/doi/10.1021/ja01178a066https://doi.org/10.1021/ja01178a066research-articleACS PublicationsRequest reuse permissionsArticle Views325Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bandwidth control of paired photons generated in monolithic Bragg reflection waveguides (2009)

Bragg reflection waveguides are considered as monolithic sources of frequency correlated photon pairs generated using spontaneous-parametric down-conversion in a AlxGa1-xAs material system. The source described here offers unprecedented control over the process bandwidth, enabling bandwidth tunability between 1 nm and 450 nm while using the same wafer structure. This tuning is achieved by exploiting the powerful control over the waveguide dispersion properties afforded by the phase-matching technique used. The offered technology provides a route for realizing electrically pumped, monolithic photon pair sources on a chip with versatile characteristics.