gebhart/patrepeval huggingface dataset:
Data from Potential Role of Jun Activation Domain–Binding Protein 1 as a Negative Regulator of p27<sup>kip1</sup> in Pancreatic Adenocarcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Reduced expression of p27 has been associated with poor prognosis in most human cancers, including pancreatic adenocarcinoma. Jun activation domain–binding protein 1 (JAB1), an activator protein (AP-1) coactivator, previously implicated in p27 degradation, is overexpressed in various tumors and correlates with low p27 expression. We examined JAB1 and p27 in normal and neoplastic pancreatic tissues. Increased JAB1 expression was seen in pancreatic carcinoma samples but not in paired normal pancreatic tissues. Immunohistochemical analysis using tissue microarrays showed that JAB1 was overexpressed in all 32 (100%) pancreatic adenocarcinoma samples tested, predominantly nuclear in 23 (72%) samples and predominantly cytoplasmic in 9 (28%) tumors. When 10% was used as a cutoff for p27 positivity, p27 was expressed in 11 (34%) of tumors; however, p27 expression was localized in the nuclei of tumor cells in only 4 (13%) of the samples. Overexpression of the JAB1 in the pancreatic carcinoma cell lines Panc-1, Mia PaCa-2, and Panc-28 resulted in decreased p27 expression. Conversely, down-regulation of JAB1 by short interfering RNA substantially increased p27 expression and inhibited progression from G&lt;sub&gt;1&lt;/sub&gt; to S phase of the cell cycle. Interestingly, JAB1-mediated p27 degradation was not impaired when S-phase kinase-interacting protein 2 (Skp2), an F-box protein required for the ubiquitination and consequent degradation of p27, was silenced. Thus, JAB1 may have an Skp2-independent p27 degradation mechanism in pancreatic cancer cells. These findings suggest that JAB1 overexpression is involved in the pathogenesis of pancreatic cancer through JAB1-mediated p27 degradation and that control of JAB1 expression is a novel therapeutic target in patients with pancreatic adenocarcinomas. (Cancer Res 2006; 66(17): 8581-9)&lt;/p&gt;&lt;/div&gt;
A mechanism for automatically and dynamically changing software components (1997)

article Free Access Share on A mechanism for automatically and dynamically changing software components Authors: Katsuhisa Maruyama NTT Software Laboratories, 3-9-11 Midori-cho Musashino-shi, Tokyo 180, Japan NTT Software Laboratories, 3-9-11 Midori-cho Musashino-shi, Tokyo 180, JapanView Profile , Ken-ichi Shima NTT Software Laboratories, 3-9-11 Midori-cho Musashino-shi, Tokyo 180, Japan NTT Software Laboratories, 3-9-11 Midori-cho Musashino-shi, Tokyo 180, JapanView Profile Authors Info & Claims ACM SIGSOFT Software Engineering NotesVolume 22Issue 3May 1997 pp 169–180https://doi.org/10.1145/258368.258417Published:01 May 1997Publication History 3citation271DownloadsMetricsTotal Citations3Total Downloads271Last 12 Months15Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Exon 3‐deleted genotype of growth hormone receptor (GHRd3) positively influences IGF‐1 increase at generation test in children with idiopathic short stature (2007)

This study demonstrates that ISS children carrying the GHRd3 allele, as a group, present a slightly higher GH sensitivity regarding short-term IGF-1 generation during hGH stimulus than children homozygous for GHRfl allele.
Untersuchungen der Desorption von Wasserstoff in metall‐organischen Gerüsten (2008)

Der Durchmesser entscheidet: Die Adsorptionsplätze von Wasserstoff in den metall-organischen Gerüsten Cu-BTC, MIL-53, MOF-5 und IRMOF-8 wurden durch thermische Desorptionsspektroskopie bei tiefen Temperaturen untersucht (siehe Diagramm). Der Zusammenhang zwischen den Desorptionsspektren und der Porenstruktur der MOFs belegt, dass die Adsorption von H2 hauptsächlich von der Porengröße bestimmt wird, wohingegen die Art des Metallzentrums einen geringeren Einfluss hat.
Comparative Effectiveness of an Interdisciplinary Pain Program for Chronic Low Back Pain, Compared to Physical Therapy Alone (2019)

3.
A note on obtaining correct marginal predictions from a random intercepts model for binary outcomes (2015)

The logistic random intercepts model can be used to obtain valid marginal predictions by integrating over the distribution of random effects.
EFFECTS OF LIPOSOME-ENCAPSULATED HEMOGLOBIN (TRM645) ON HUMAN IMMUNE SYSTEM: EVALUATION IN IMMUNODEFFICIENT MICE RECONSTITUTED WITH HUMAN STEM CELLS (2005)

Background. Safety evaluation in animals sometimes overlooks untoward effects in humans. Liposome-encapsulated hemoglobin (TRM645) is tested in mice reconstituted with human immune system as a preclinical safety evaluation. Methods. Newly established immunodeficient mice (NOG) were transfused with 2x105 hematopoietic stem cells isolated from human cord blood. In those mice, changes in immunocompetent cells in peripheral blood, spleen and bone marrow were examined before and 2 days after 1% body weight intravenous administration of TRM645 (n=4), empty liposome (n=4), and phosphate buffered saline (n=4) using immunohistochemical and flow-cytometrical techniques. Results. Although there was an increase in numbers of human CD4+ (helper T) cells, CD8+ (suppressor T) cells and CD19+ (B) cells in the spleen of mice receiving liposome (TRM645 or empty liposome) as compared to mice receiving saline, these cells were all in resting state (CD25-). Cellularity, distribution and maturation of these human cells in bone marrow or peripheral blood were comparable among the groups. Conclusion. The increase of resting human lymphocytes in mouse spleen receiving liposome may suggest a natural metabolic pathway where liposome is captured and degraded by the reticuloendothelial system. In a short-term there was no apparent untoward effect of TRM645 per se as these mice are all active and healthy. Studies on effects of repeated administration of TRM645 on long-term, and on active immunization in the “human mice” are underway.
Semi-automated checking for regulatory compliance in e-Health (2021)

One of the main issues of every business process is to be compliant with legal rules. This work presents a methodology to check in a semi-automated way the regulatory compliance of a business process. We analyse an e-Health hospital service in particular: the Hospital at Home (HaH) service. The paper shows, at first, the analysis of the hospital business using the Business Process Management and Notation (BPMN) standard language, then, the formalization in Defeasible Deontic Logic (DDL) of some rules of the European General Data Protection Regulation (GDPR). The aim is to show how to combine a set of tasks of a business with a set of rules to be compliant with, using a tool.
Zentralperspektive (1976)

Bei der Fluchtpunktkonstruktion wird die Sehstrahlenprojektion auf den Grundriß beschränkt. Aus dem Aufriß werden nur noch die Höhen übernommen.
SERS Biosensor Using Metallic Nano‐Sculptured Thin Films for the Detection of Endocrine Disrupting Compound Biomarker Vitellogenin (2014)

A biosensor chip is developed for the detection of a protein biomarker of endocrine disrupting compounds, vitellogenin (Vg) in aquatic environment. The sensor chip is fabricated by immobilizing anti-Vg antibody on 4-Aminothiophenol (4-ATP) coated nanosculptured thin films (nSTFs) of silver on Si substrates. The biosensor is based on the SERS of 4-ATP, enhanced by the Ag nSTFs. Before the fabrication of the sensor, the performance of the enhancement is optimized with respect to the porosity of nSTFs. Further, the biosensor is developed on the nSTF with optimized enhancement. The SERS signals are recorded from the sensor chip for varying concentrations of Vg. A control experiment is performed on another similar protein Fetuin to confirm the specificity of the sensor. The repeatability and reusability of the sensor, along with its shelf life are also checked. The limit of detection of the sensor is found to be 5 pg mL −1 of Vg in PBS within our experimental window. Apart from high sensitivity, specificity and reusability, the present sensor provides additional advantages of miniaturization, requirement of very small volumes of the analyte solution (15 μL) and fast response as compared to conventional techniques e.g., ELISA, as its response time is less than 3 minutes.
Center Weighted Median Filter Application to Time Delay Estimation in Non-Gaussian Noise Environment (2019)

A task of time delay estimation using two or more sensors that receive and process noise-like wideband signals embedded in spatially uncorrelated noise can be treated as classical. A problem arises if environment noise is non-Gaussian and has heavy tails. Then, due to several factors, probability of appearing abnormal elementary time delay estimates can be large, especially if conventional method of cross-correlation signal processing is applied. Different methods to cope with the problem have been proposed including the use of robust DFT at initial stages. However, this reduces computational efficiency of processing radically. Here, we propose a specific modification of classical processing that presumes pre-processing of noisy received signals using center weighted median filter. We show that this easy and fast step allows providing better performance than procedures based on robust DFT. Considerable reduction of abnormal error probability is observed and the method can operate in conditions of limited a priori information about characteristics of additive non-Gaussian noise.
DNA-Mediated Prophage Induction in Bacillus subtilis Lysogenic for φ105c4 (1973)

Prophage was induced when strains of Bacillus subtilis 168 lysogenic for phi105c4 were grown to competence and exposed to specific bacterial DNAs. The time course of phage production was similar to that observed for mitomycin C induction of wild-type prophage. Induction was directly dependent upon DNA concentration up to levels which were saturating for the transformation of bacterial auxotrophic markers. The extent of induction varied with the source of DNA. The burst of phage induced by DNA isolated from a W23 strain of B. subtilis was fivefold less than that induced by DNA from B. subtilis 168 strains, while B. licheniformis DNA was completely inactive. This order of inducing activity was correlated with the ability of the respective DNAs to transform auxotrophic markers carried by one of the phi105c4 lysogens. Differences in inducing activity also were observed for different forms of phi105 DNA. The DNAs isolated from phi105 phage particles and phi105c4 lysogens were inactive, whereas DNA from cells lysogenized by wild-type phi105 induced a burst of phage. When tested for transforming activity, however, both phi105c4 and phi105 lysogen DNAs were equally effective. An induction mechanism which involves recombination at the prophage insertion site is proposed to explain these differences.
Complex Surgical Management of Radiation-Associated Left Retroperitoneal Sarcoma (2022)

Radiation-associated sarcomas (RASs) are rare entities that tend to have an aggressive course and poor prognosis. Criteria for diagnosis of radiation-associated sarcoma include therapeutic radiation preceding the development of sarcoma, sarcoma arising within or near the irradiated field, and tumor histology that is distinct from the primary tumor necessitating radiation. Despite their relatively uncommon occurrence, RASs are a well-established complication of radiation therapy. We present the complex, multidisciplinary surgical management of a patient with multi-compartmental radiation-associated sarcoma of the left retroperitoneum occurring nearly 25 years after undergoing whole trunk radiation for Hodgkin's lymphoma.
Adobe Dreamweaver CS4 Bible (2009)

Updated version of the bestselling Dreamweaver Bible series Packed with hands-on instruction and step-by-step tutorials, the Dreamweaver CS5 Bible has everything you need to harness the incredible power of this amazing Web development tool.Starting with Dreamweaver basics, expert author and Adobe guru Joe Lowery (Adobe CS4 Web Workflows and Adobe Dreamweaver CS4 Bible) guides you through the ins-and-outs of Dreamweaver showing you how to build dynamic, data-driven sites in no time. Details how to use Dreamweaver with PHP, ASP.NET, ColdFusion and more to access and work with live backend data Describes designing for and working with popular Content Management Systems (CMS) including WordPress, Joomla, and Drupal Includes how-to's on using HTML, CSS, and JavaScript in Dreamweaver to build attractive dynamic websites, as well as comprehensive information on creating and working with both design and code templates to provide consistency across a web site with minimal effort Dreamweaver has established itself as one ofthe leading Web development tools and Dreamweaver CS5 Bible is the must-have learning tool and reference guide for any Web developer using Dreamweaver.
Proactive Risk Navigation System for Real-World Urban Intersections (2020)

We consider the problem of intelligently navigating through complex traffic. Urban situations are defined by the underlying map structure and special regulatory objects of e.g. a stop line or crosswalk. Thereon dynamic vehicles (cars, bicycles, etc.) move forward, while trying to keep accident risks low.Especially at intersections, the combination and interaction of traffic elements is diverse and human drivers need to focus on specific elements which are critical for their behavior. To support the analysis, we present in this paper the so-called Risk Navigation System (RNS). RNS leverages a graph-based local dynamic map with Time-To-X indicators for extracting upcoming sharp curves, intersection zones and possible vehicle-to-object collision points.In real car recordings, recommended velocity profiles to avoid risks are visualized within a 2D environment. By focusing on communicating not only the positional but also the temporal relation, RNS potentially helps to enhance awareness and prediction capabilities of the user.
High resolution refinement of β‐galactosidase in a new crystal form reveals multiple metal‐binding sites and provides a structural basis for α‐complementation (2000)

The unrefined fold of Escherichia coli beta-galactosidase based on a monoclinic crystal form with four independent tetramers has been reported previously. Here, we describe a new, orthorhombic form with one tetramer per asymmetric unit that has permitted refinement of the structure at 1.7 A resolution. This high-resolution analysis has confirmed the original description of the structure and revealed new details. An essential magnesium ion, identified at the active site in the monoclinic crystals, is also seen in the orthorhombic form. Additional putative magnesium binding sites are also seen. Sodium ions are also known to affect catalysis, and five putative binding sites have been identified, one close to the active site. In a crevice on the protein surface, five linked five-membered solvent rings form a partial clathrate-like structure. Some other unusual aspects of the structure include seven apparent cis-peptide bonds, four of which are proline, and several internal salt-bridge networks. Deep solvent-filled channels and tunnels extend across the surface of the molecule and pass through the center of the tetramer. Because of these departures from a compact globular shape, the molecule is not well characterized by prior empirical relationships between the mass and surface area of proteins. The 50 or so residues at the amino terminus have a largely extended conformation and mostly lie across the surface of the protein. At the same time, however, segment 13-21 contributes to a subunit interface, and residues 29-33 pass through a "tunnel" formed by a domain interface. Taken together, the overall arrangement provides a structural basis for the phenomenon of alpha-complementation.
Genetic diversity and stand structure of neighboring white willow (Salix alba L.) populations along fragmented riparian corridors: a case study (2018)

Abstract Remnant riparian woodlands have an important landscape function, due to their ability to act as ecological corridors. In this study we used molecular markers to assess the genetic variation occurring within and between spontaneous white willow (Salix alba L.) riparian woodlands. Our main goal was to evaluate the extent to which the fragmentation of a woodland corridor along a heavily impacted river in northeastern Italy and stand structural conditions may have affected the population genetics. Although having different structures, the three examined white willow stands showed high estimates of genetic similarity, as well as low genetic differentiation between them, indicating that they shared a similar gene pool and that the stands could result from a common set of individual genotypes, and should be regarded as metapopulations. The magnitude of genetic diversity within each of the stands and genetic differentiation between them, despite their high sexual reproductive capacity associated with a highly marked gene flow, suggest that these stands are dynamic and capable of adaptive responses to possible changes in their fluvial environment. However, the factors influencing genetic diversity should be interpreted from a long-term perspective. Fluvial geomorphic patterns in regulated rivers may be modified to a degree that could lead to changes in dispersal processes, sexu­al reproduction vs. asexual propagation, and hence genetic diversity.
Observation of Flow Asymmetry Over the Rear of Notchback Vehicles (2007)

&lt;div class="htmlview paragraph"&gt;This paper presents a series of observations of time-averaged wake asymmetry for a range of “&lt;i&gt;notchback&lt;/i&gt;” vehicle geometries. The primary focus is on a reduced scale experiment using full-sized saloon geometry. Substantial flow asymmetry was observed in the vehicle “&lt;i&gt;notch&lt;/i&gt;”. Similar asymmetries are reported for a full scale experiment on the same geometry along with others as diverse as production models of a luxury and mid-sized saloon; basic car shapes and a simple body. In one case a physical explanation is proposed, based on the degeneration of an unstable symmetric wake structure.&lt;/div&gt;
Design of Efficient Resonator-Enhanced Electro-Optic Frequency Comb Generators (2020)

Resonator-enhanced electro-optic (RE-EO) frequency comb generators produce broad combs by coupling an optical field to a resonator containing a phase modulator driven at a harmonic of the resonator free spectral range (FSR). Recent advances in integration technologies have opened up the possibility of fabricating low-loss, efficient, and tunable ring-based RE-EO comb generators. In this work, we analyze the properties of a canonical ring-based RE-EO comb generator and propose a new dual-ring comb generator to increase comb conversion efficiency, an especially important characteristic for comb-based optical communications systems. After a brief review of RE-EO comb generator properties in the case of resonant operation, i.e., when the optical frequency and the modulation frequency are harmonics of the resonator FSR, we analyze the effect of input optical phase noise and modulation phase noise on the resulting comb. Additionally, we show analytically that in non-resonant operation the optical frequency offset and the modulation frequency offset can be much larger than the linewidth of the resonator, increasing the tolerance to fabrication errors. Then, we develop and validate numerical models to predict the output spectrum in the presence of dispersive waveguides, which cannot be modeled analytically. Using these accurate models, we analyze a dual-ring RE-EO comb generator that uses a small coupling ring to increase the conversion efficiency to 32%, compared to the 1.3% efficiency of a single-ring RE-EO comb generator. We then analyze a point-to-point inter-data center optical link and determine that a dual-ring RE-EO comb generator can support high-capacity coherent links at 20 Tb/s per fiber.
Kinetics of Heterogeneous Nucleation in Supersaturated Vapor: Fundamental Limits to Neutral Particle Detection Revisited (2012)

We examine the nucleated (with barrier) activation of perfectly wetting (zero contact angle) particles ranging from essentially bulk size down to approximately 1-nm mass diameter. While similar studies trace back to the pioneering work of Fletcher, we present here a novel approach to the analysis based on general area constructions that enable key thermodynamic properties, including surface and bulk contributions to nucleation work, to be interpreted geometrically with reference to the Kelvin curve. The kinetics of activation are described in more detail in terms of the mean first passage time (MFPT) for barrier crossing. MFPT theory and benchmark calculations are used to develop and test a new approximate-but-simpler-to-use analytic expression for the barrier crossing rate. The present study is motivated by recent condensation particle counter (CPC) studies that appear to finally establish the long-predicted detection of "sub-Kelvin" particles in the nano-size regime. Corresponding states thermodynamic and kinetic scaling approaches are used to facilitate the correlation and selection of optimal CPC working fluids and operating conditions based on a new metric for heterogeneous nucleation, the signal-to-noise ratio, and physical and chemical properties. Copyright 2012 American Association for Aerosol Research
High-speed modulation of a compact silicon ring resonator based on a reverse-biased pn diode (2009)

High speed modulation based on a compact silicon ring resonator operating in depletion mode is demonstrated. The device exhibits an electrical small signal bandwidth of 19 GHz. The device is therefore a candidate for highly compact, wide bandwidth modulators for a variety of applications.
Selective Damage to Either the “M” Or “P” Cell Pathway in Human Retinal Disease: Implications for Visual Processing (1996)

Studies in primates have shown there to be 2 main visual afferent pathways (magno and parvo) operating in parallel with different functional roles. Disease state may selectively affect one or other of these, as shown by particular sensory losses. In cases of treated Cuban tropical "neuropathy" (a retinopathy also occurs) visual acuity and achromatic contrast sensitivity are preserved although colour vision is severely affected indicating selective preservation of the "magno" pathway. In Melanoma Associated Retinopathy, red-green colour vision is preserved although achromatic contrast sensitivity for low spatial frequencies, and the detection of motion is damaged suggesting preferential damage to the "magno" pathway. Our studies illuminate two controversial aspects of the P and M systems: the role of type II parvocellular cells in colour vision and the role of M cells in detecting stimuli of low spatial and low temporal frequency.
Angular correlation measurements over the intermediate structure inAs71 (1979)

Angular correlations in the $^{70}\mathrm{Ge}$($p$,${p}^{\ensuremath{'}}\ensuremath{\gamma}$)$^{70}\mathrm{Ge}$ reaction have been measured for two of the five substructures nested in the reported $\frac{1}{{2}^{+}}$ intermediate structure in $^{71}\mathrm{As}$ centered at ${E}_{p}=5.05$ MeV. The spins of both substructures were determined as being $\frac{5}{2}$ or greater casting doubt on the interpretation of this cluster of states as an example of intermediate structure.NUCLEAR REACTIONS $^{70}\mathrm{Ge}$($p$,${p}^{\ensuremath{'}}\ensuremath{\gamma}$)$^{70}\mathrm{Ge}$, $E=4.95 \mathrm{to} 5.19$ MeV. Deduced spins of resonances at $E=5.04 \mathrm{and} 5.14$ MeV. Enriched target.