gebhart/patrepeval huggingface dataset:
Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cells (2015)

Mitotic centromere-associated kinesin (MCAK) is the best characterized member of the kinesin-13 family and plays important roles in microtubule dynamics during mitosis. Its activity and subcellular localization is tightly regulated by an orchestra of mitotic kinases, such as Aurora B. It is well known that serine 196 of MCAK is the major phosphorylation site of Aurora B in Xenopus leavis extracts and that this phosphorylation regulates its catalytic activity and subcellular localization. In the current study, we have addressed the conserved phosphorylation site serine 192 in human MCAK to characterize its function in more depth in human cancer cells. Our data confirm that S192 is the major phosphorylation site of Aurora B in human MCAK and that this phosphorylation has crucial roles in regulating its catalytic activity and localization at the kinetochore/centromere region in mitosis. Interfering with this phosphorylation leads to a delayed progression through prometa- and metaphase associated with mitotic defects in chromosome alignment and segregation. We show further that MCAK is involved in directional migration and invasion of tumor cells, and interestingly, interference with the S192 phosphorylation affects this capability of MCAK. These data provide the first molecular explanation for clinical observation, where an overexpression of MCAK was associated with lymphatic invasion and lymph node metastasis in gastric and colorectal cancer patients.
ISDN Data Networking Applications in the Corporate Environment (1988)

The introduction of the Integrated Services Digital Network (ISDN) into the public switched network holds the promise of combining multiple data networks and voice applications into a single, integrated digital network. This paper shows how these promises have been turned into reality at the headquarters of the McDonald's Corporation in Oak Brook, Illinois. ISDN service to McDonald's is provided by Illinois Bell Telephone via a central office implementation of the AT&T 5E4(2) software generic on the AT&T 5ESS® switch. Applications running on multiple data networks have been integrated into ISDN, resulting in improved performance and increased flexibility for the end user. This paper describes how these existing data networks have been integrated into ISDN and discusses the advantages of an ISDN network.
Efficient spatial charge separation and transfer in ultrathin g-C3N4 nanosheets modified with Cu2MoS4 as a noble metal-free co-catalyst for superior visible light-driven photocatalytic water splitting (2018)

Cu<sub>2</sub>MoS<sub>4</sub> was employed as a promising non-noble metal co-catalyst to couple with g-C<sub>3</sub>N<sub>4</sub> for highly efficient water splitting.
Amorphous carbon-silica composites bearing sulfonic acid as solid acid catalysts for the chemoselective protection of aldehydes as 1,1-diacetates and for N-, O- and S-acylations (2011)

Amorphous carbon-silica composites bearing sulfonic acid derived from inexpensive natural organic compounds (glucose, maltose, cellulose, chitosan and starch) were prepared by partial carbonization followed by sulfonation and their catalytic activity was evaluated for the protection of aldehydes as 1,1-diacetates and for N-, O- and S-acylations under solvent-free conditions. Different biomaterials have been chosen, with a view to select the most active solid acid catalyst. Carbon-silica composites were characterized by FTIR, XRD and elemental analysis. Sulfonated carbon-silica composite derived from starch was found to be the most active and could be recycled for several runs without loss of significant activity. It was also characterized by TGA, SEM and TEM.
WorldBrush (2015)

We present a novel approach for the interactive synthesis and editing of virtual worlds. Our method is inspired by painting operations and uses methods for statistical example-based synthesis to automate content synthesis and deformation. Our real-time approach takes a form of local inverse procedural modeling based on intermediate statistical models: selected regions of procedurally and manually constructed example scenes are analyzed, and their parameters are stored as distributions in a palette, similar to colors on a painter's palette. These distributions can then be interactively applied with brushes and combined in various ways, like in painting systems. Selected regions can also be moved or stretched while maintaining the consistency of their content. Our method captures both distributions of elements and structured objects, and models their interactions. Results range from the interactive editing of 2D artwork maps to the design of 3D virtual worlds, where constraints set by the terrain's slope are also taken into account.
Electron-impact ionization and energy loss of 27-MeV/uXe35+incident ions channeled in silicon (1989)

We have measured the emerging charge-state distribution of 27-MeV/u ${\mathrm{Xe}}^{35+}$ beams channeled through a thin Si single crystal, and deduced electron impact ionization cross sections for ${\mathrm{Xe}}^{35+}$ to ${\mathrm{Xe}}^{45+}$ by 14.7-keV electrons. They are \ensuremath{\approxeq}2 to 4 times higher than predicted by usually accepted empirical estimations. We have also measured the energy loss versus emerging charge state. For hyperchanneled ${\mathrm{Xe}}^{\mathrm{Q}+}$ ions, the stopping power depends only on the mean (and not on the actually sampled) density of valence electrons and compares well with the prediction of the electron gas model.
Theoretical Study of Step Coverage by the Sputtering Method. (1993)

The process of film formation on trenches is analysed by calculating the motion of sputtered atoms in the pressure range of 0. 1-1 Pa. The step coverage depends on the pressure, the deposition probability, and the location of the trench. The step coverage of a trench located near the edge of the substrate is poor at 0. 1 Pa. However, it is much better at 0. 5 Pa. The decrease of the deposition probability drastically improves the step coverage, even at O. 1 Pa.
Real-time RT-PCR for H5N1 avian influenza A virus detection (2007)

The recent recurrence of highly pathogenic avian influenza virus A H5N1 was firstly reported in mid-December 2003 and continued through 2005. This study describes a sensitive and specific real-time RT-PCR method for the detection of influenza A subtype H5 and for monitoring virus loads. Using serial dilutions of influenza A H5N1 cultures, this assay reproducibly determined the lowest detection limit to be approximately 5 x 10(-2) 50 % egg infective doses (EID(50)). In contrast, the minimum detection limit was approximately 3 EID(50) in conventional RT-PCR with WHO primers and 10 EID(50) in antigen-capture ELISA. In tests of serial dilutions of in vitro-transcribed influenza A H5 gene RNA, there was linear amplification from 40 copies to 4 x 10(8) copies of target RNA per reaction and approximately six copies, and sometimes even as few as three copies, of target RNA tested positive in our assay. Thirty-five throat swabs from ill birds were tested: 33 samples tested positive using this assay. In comparison, 27, 13 and 19 samples tested positive using conventional RT-PCR, antigen-capture ELISA and virus isolation, respectively. To evaluate further the sensitivity of this real-time RT-PCR, a standard panel and 60 H5N1 isolates that contained different clades of influenza virus A/H5N1 were tested and all tested positive. To evaluate the specificity of the assay, 60 throat swabs from patients infected with influenza virus A H1 were tested; all were negative. Thirteen other viruses were also tested and all tested negative.
Tailoring Acoustic Beam Momentum and Angular Momentum (2013)

As an analog to optical beams we have begun to explore limited phase and amplitude control of a 1000-element ultrasonic transducer array system, with emphasis upon tailored transfer of acoustic beam momentum and angular momentum.
Stopping Personalized PageRank without an Error Tolerance Parameter (preprint of accepted manuscript) (2020)

Personalized PageRank (PPR) is a popular scheme for ranking the relevance of network nodes to a set of seed ones through a random walk with restart process. Calculating the ranks of all network nodes often involves the power method, which iterates the PPR formula until convergence to an empirically selected numerical tolerance. However, finding a tolerance that is not so lax as to impact pairwise node comparisons but not so strict as to require a high number of iterations to converge requires time-consuming empirical investigation. In this work we aim to avoid this investigation by stopping power method iterations when node rank order is robust against subsequent changes. To do this, we analyse the expected fraction of random walks considered at a given iteration and identify a potential stopping point that depends on a (fixed) confidence level of future iterations preserving node order. Experiments on four real-world networks show that a confidence level of 98% runs in a fraction of the time and yields more than 0.999 Spearman correlation with the node order of 10^-20 numerical tolerance. Furthermore, that stopping point is comparable to empirically selecting a numerical tolerance that yields robust node order.
Research on recognition of semantic chunk boundary in Tibetan (2014)

Semantic chunk is able to well describe the sentence semantic framework. It plays a very important role in Natural Language Processing applications, such as machine translation, QA system and so on. At present, the Tibetan chunk researches are mainly based on rule-methods. In this paper, according to the distinctive language characteristics of Tibetan, we firstly put forward the descriptive definition of the Tibetan semantic chunk and its labeling scheme and then we propose a feature selection algorithm to select the suitable ones automatically from the candidate feature-templates. Through the experiment conducted on the two different kinds of Tibetan corpus, namely corpus-sentence and corpus-discourse, the F-Measure achieves 95.84%, 94.95% and 91.97%, 88.82% by using of Conditional Random Fields (CRF) model and Maximum Entropy (ME) model respectively. The positive results show that the definition of Tibetan semantic chunk in this paper is reasonable and operable. Furthermore, its boundary recognition is feasible and effective via statistical techniques in small scale corpus.
The Stratix II logic and routing architecture (2005)

This paper describes the Altera Stratix II™ logic and routing architecture. This architecture features a novel adaptive logic module (ALM) that is based on a 6-LUT, but can be partitioned into two smaller LUTs to efficiently implement circuits containing a range of LUT sizes that arises in conventional synthesis flows. This provides a performance increase of 15% in the Stratix II architecture while reducing area by 2%. The ALM also includes a more powerful arithmetic structure that can perform two bits of arithmetic per ALM, and perform a sum of up to three inputs. The routing fabric adds a new set of fast inputs to the routing multiplexers for another 3% improvement in performance, while other improvements in routing efficiency cause another 6% reduction in area. These changes in combination with other circuit and architecture changes in Stratix II contribute 27% of an overall 51% performance improvement (including architecture and process improvement). The architecture changes reduce area by 10% in the same process, and by 50% after including process migration.
The Resident and the Borderline In-patient: A Supervisor's Perspective (1981)

The problems of residents working intensively with borderline inpatients in a general hospital psychiatric unit area described. The resident feels pressure because of inexperience with intensive psychotherapy, and the high visibility of working in a closely supervised team setting. The border line patient baffles the resident with his defensive activity characterized by splitting, erotization, idealization, and negative therapeutic response. These difficulties complicate supervision, necessitating the supervisor's alertness to being caught in team splits or collusion with the resident's unrealistic hopefulness or nihilism. Supervision must actively address the resident's countertransference and the supervisor's counterresponses. Clinical vignettes illustrate the various problems.
Facile Synthesis of Large‐Area Ultrathin Hexagonal BN Films via Self‐Limiting Growth at the Molten B2O3 Surface (2013)

A self-limiting growth process based on the interface-controlled reaction of molten boron oxide (B2 O3 ) with ammonia (NH3 ) is demonstrated for the facile and lost-cost synthesis of ultrathin (20-30 nm) crystalline hexagonal boron nitride (h-BN) films over large areas. The as-grown h-BN films are of high quality, being densely continuous, uniform and smooth, and highly transparent over a broad wavelength range.
Central circulation during exercise after venesection and reinfusion of red blood cells (1976)

To study central circulation at different levels of hemoglobin (Hb) concentration, five subjects performed submaximal and maximal exercise in three different situations: 1) control, 2) after venesection of 800 ml of whole blood, and 3) after reinfusion of the red blood cells about 30-35 days after venesection. Maximal oxygen uptake (VO2 max) decreased from 4.27 l-min-1) at control to 4.03 l-min-1 after venesection (P less than 0.05) and increased to 4.61 l-min-1 after reinfusion (P less than 0.05). Maximal values on cardiac output (Q), heart rate (HR), and stroke volume (SV) were the same in the three situations. Thus, there was no compensatory increase in Qmax due to the lowered arterial oxygen content (Cao2) after venesection. An increase of the Cao2 (Hb concentration) and a lowering of the Cvo2 contributed equally to the increased VO2 max after reinfusion. At a given submaximal VO2, HR and blood lactates were increased at lowered Hb concentration and decreased at increased Hb concentration over control levels. Correlation coefficient for the change in Q in relation to the acute change in Hb concentration at a given submaximal VO2 was -0.49 (P less than 0.05).
Mixing of Fast Pyrolysis Oil and Black Liquor: Preparing an Improved Gasification Feedstock (2016)

Co-gasification of fast pyrolysis oil and black liquor can be used to increase the size and improve profitability of pulp mill integrated biorefineries. The acids present in pyrolysis oil limit the amount that can be mixed into black liquor without causing precipitation of the black liquor dissolved lignin. This work shows that a simple model based on pyrolysis oil total acid number, including weak phenolic acids, can be used to predict the maximum pyrolysis oil fraction in blends. The maximum oil fraction is 20-25% for typical pyrolysis oil but can be increased up to at least 50% mass, corresponding to 70% energy, by addition of base. Thermodynamic equilibrium calculations are used to understand the effects of blend composition, including any added base, on the performance of a commercial scale gasification process. A substantial increase in overall gasification efficiency is observed with increasing pyrolysis oil fraction.
The effect of hemiketals on the relaxivity of endohedral gadofullerenols (2015)

Gd@C<sub>82</sub>(OH)<sub>x</sub>O<sub>y</sub> with more hemiketals show much higher relaxivities than those with fewer hemiketals.
SYNTHESIS OF 5-FLUORO-PRGSTAGLANDINS (1979)

Abstract (5E)- And (5Z)-5-fluoro-prostaglandin(PG)F2α methyl esters 1 and 2 were synthesized via decarboxylative elimination reaction from key intermediate α-fluoro-β-hydroxy ester 7. 5-Fluoro-6-keto-PGE1 methyl ester 3 was also synthesized from the key intermediate 7. These 5-fluoro-PGs 1, 2 and 3 showed interesting biological properties.
The thermal step technique: an advanced method for studying the properties and testing the quality of polymers (1998)

It is well known that the physical properties of a polymer alter with time. This phenomenon—ageing—is strongly related to the external factors acting upon the polymer and to the manufacturing process. An appropriate process could prevent the premature and undesired changes in the characteristics of a polymeric material. For this reason, considerable efforts are made to understand the mechanism of polymer degradation. Past studies have shown that the existence of electrical charges in the bulk of polymers can affect their properties significantly. These charges—usually called space charges or space charge—were first observed in polymers used for electrical insulation and therefore submitted to high electric fields. Some recent studies, particularly those presented in this paper, proved that space charge exists in almost every polymer. It has been shown that space charge can be present within the material from the very manufacturing process, without previous submission to stress. The increase of the amount of the space charge seems strongly related to the deterioration of the physical properties of polymers. Space charge measurements can therefore be considered as a test of quality for polymers. This paper is dedicated to a method for measuring space charge: the Thermal Step Method (TSM). The physical basis of the technique, as well as its applications, are presented. Results obtained on various polymers are presented and discussed. The results show that the features of this technique, particularly its high sensitivity, make it an appropriate tool for the characterization of a wide variety of materials. The TSM could also be associated with other physical, chemical or physico-chemical techniques. © 1998 SCI.
52.2: Display with Arbitrary Primary Spectra (2008)

Abstract Individual differences in colour sensation of a single display (observer metamerism) can be reduced by synthesizing and adapting the primary spectra to the physiological spectral response of the observer. The technique can also be used to synthesize the eigenspectra in multispectral imaging, and thereby provide an alternative to multi‐primary displays.
Improvement of extrathymic T cell type of large granular lymphocyte (LGL) leukemia by cyclosporin A: the serum level of Fas ligand is a marker of LGL leukemia activity (2000)

We report a case of gammadelta T-cell-type large granular lymphocyte (LGL) leukemia (CD3 +,CD8 +, CD57 +,TCR gammadelta+), which was accompanied by pure red cell aplasia, neutropenia and thrombocytosis. Southern blotting analysis of the T-cell receptor beta gene showed the germline configuration, but clonal TCR J gamma rearrangements were identified. These granular lymphocytes demonstrated non-major histocompatibility complex-restricted cytotoxicitity. The serum-soluble FasL (sFasL) concentration of this patient was very high, whereas the serum levels of tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), interleukin-1 beta (IL-1beta), interleukin-2 (IL-2) and thrombopoietin were normal. After treatment with cyclosporin A, anemia and thrombocytosis were improved, and LGL and the elevated sFasL concentration decreased. These observations suggested that FasL may have played a role in the establishment of the clinical symptoms of this patient and could be useful as an indicator of disease activity.
Differentiated Services Quality of Service Policy Information Base (2003)

This document describes a Policy Information Base (PIB) for a device implementing the Differentiated Services Architecture. The provisioning classes defined here provide policy control over resources implementing the Differentiated Services Architecture. These provisioning classes can be used with other none Differentiated Services provisioning classes (defined in other PIBs) to provide for a comprehensive policy controlled mapping of service requirement to device resource capability and usage.
Water-Production Diagnosis Using Transient Test With Multiphase Flowmeter (2008)

Abstract Accurate determination of oil, water, and gas production rates is an important element of oilfield management and optimization. Multiphase flow meters (MPFM) are being accepted more and more for well testing, reservoir management, production allocation, production monitoring, and fiscal metering. In addition to common MPFM applications, this study shows how a multiphase flow meter may be used as a valuable tool to evaluate water production problems of the well by imposing transient flowing conditions to the well and tracking characteristic parameters such as flowrates, water cut and gas oil ratio with the equipment during the test. Representative curves are shown in this study in order to identify some common wellbore problems associated with water conformance. The curves were obtained through numerical reservoir simulation using a number of cases related to the most important problems: water channeling in stratified formations, mechanical wellbore integrity, water conning, and oil-water contact advance. The flowrate at the well should be shortened to a half of the current flowrate with a choke for several hours then, the dimensionless pattern curves of the water cut and gas oil ratio gathered in this study should be matched with the measurement of the MPFM on site in order to characterize the nature of the water problem. This application represents a new tool used to identify the sources of water production. The tool is easy and quick to apply, and complements other analytical techniques being used like diagnostics plots based on production history, water-oil ratio performance and production logs. All of them are used to differentiate between the different mechanisms of water invasion, so that an appropriate treatment may be selected to control undesirable water production.
Message-oriented Middleware for Scalable Data Analytics Architectures (2015)

The democratization of Internet allowed many more people to use online services and enjoy their benefits. The traffic towards websites became tremendous those recent years, especially with the apparition of social networks. Mobile application, televisions and other non--‐computer devices also get connected to the Internet and use it to provide services to the end--‐users: Video on--‐demand, music streaming and so on. These applications rely on powerful backend servers that handle the requests made by devices and provide statistics and metrics about application usage. These metrics can be generated by aggregating the access logs (e.g. HTTP requests log), logs that are potentially extremely large. Big data tools and analytics, providing a way to handle this huge number of records, come then in hand, as typical client--‐server architectures, with a single database storing all the data, reach their limits in terms of performance and capacity. Data duplication, combined to dedicated and specialized databases storing it, is the key to efficient data handling. How to fill up these databases in an elegant, efficient and scalable manner is the remaining question, and message--‐oriented middleware may be a viable answer. This project aims at exploring the capabilities of such middleware, identifying what are the benefits and the drawbacks in using them and presenting how they can be integrated in a real--‐world application that needs to aggregate events and logs on a large scale. Apache Kafka and RabbitMQ, two message--‐oriented middleware, are benchmarked and compared, on both performance metrics and qualitative criteria. A fully working proof--‐ of--‐concept (of an already--‐existing industry product modified to use a message--‐oriented middleware and a specialized data warehouse system) is developed and presented, to conclude on the usefulness of message--‐oriented middleware when designing scalable data analytics architectures.