gebhart/patrepeval huggingface dataset:
Studies in biomimetic alkaloid syntheses. 6. Alternative pathways to secodines and their acyclic enamino acrylate analogs. Total syntheses of desethylibophyllidine, D-norvincadifformine, desethylvincadifformine, 20-methyldesethylvincadifformine, and 3-oxovincadifformine (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in biomimetic alkaloid syntheses. 6. Alternative pathways to secodines and their acyclic enamino acrylate analogs. Total syntheses of desethylibophyllidine, D-norvincadifformine, desethylvincadifformine, 20-methyldesethylvincadifformine, and 3-oxovincadifformineMartin E. Kuehne, Thomas H. Matsko, John C. Bohnert, Linda Motyka, and David Oliver-SmithCite this: J. Org. Chem. 1981, 46, 10, 2002–2009Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://doi.org/10.1021/jo00323a007RIGHTS & PERMISSIONSArticle Views597Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Appendicularia of Japanese waters (1907)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Incorporating Recent Advances To Make the TRISS Approach Universally Available (2006)

Recent advances in anatomic and physiologic scoring markedly simplify TRISS-type models at no cost to prediction. This approach uses routinely available data, requires up to seven fewer terms, and predicts at least as well as the original TRISS. These findings could increase the availability of accurate trauma scoring tools to smaller trauma facilities.
Suggestion to supplement Shigella flexneri classification scheme with the subserovar Shigella flexneri 4c: phenotypic characteristics of strains (1988)

A new serovar of Shigella flexneri has been isolated with increasing frequency in the USSR. It has the antigenic formula IV:7,8. We suggest that it be incorporated into the classification scheme as S. flexneri subserovar 4c. The 212 strains of this proposed subserovar examined to date display biochemical and serological properties typical of the species, are sensitive to the genus-specific bacteriophage, and cause keratoconjunctivitis in the Sereny test.
Submicrometer Rod-Structured Na7V4 (P2O7)4(PO4)/C as a Cathode Material for Sodium-Ion Batteries (2021)

A vanadium-based mixed polyanionic material Na7V4(P2O7)4(PO4) (NVPP) has a high working potential of around 4.0 V vs Na+/Na due to the presence of pyrophosphate with strong electronegativity. In addition, NVPP has intrinsically long cycle life. A carbon-coated rod-structured NVPP powder is synthesized by a scalable solid-state reaction method with poly(vinyl alcohol) as the carbon source. As a cathode, the optimal NVPP sample can deliver discharge capacities of 92.1 and 86.4 mA h g–1 at 0.2 and 10C, respectively, in the voltage range of 2.5–4.2 V. It also exhibits a good cycling stability with a capacity retention of 73% after 550 cycles at a 10C rate. Based on XRD analysis, the volume change of the NVPP is less than 4% during the charge and discharge processes. In addition, NVPP also accommodates more sodium ions in the lattice in a voltage window of 2.5–4.2 V vs Na+/Na.
Effects of Lactiplantibacillus plantarum PS128 on alleviating canine aggression and separation anxiety (2022)

Certain strains of Lactiplantibacillus were found to have a positive impact on host neuromodulation through the gut-brain axis and thus ameliorate emotional and behavioral problems. A number of researches have been performed on humans, mice and rats; however, studies on dogs are limited. Forty-five dogs with behavioral problems were enrolled in this study, including aggression (n = 22), separation anxiety (n = 15), compulsive disorder (n = 7) and unclassifiable inappropriate behavior (n = 1, excessive barking). The behavioral diagnosis was made based on the primary behavioral consultation questionnaires and the careful interrogations at interviews. Lactiplantibacillus plantarum PS128 (PS128) probiotic was administered to these physically healthy dogs with behavioral problems over a course of two weeks to determine the probiotic effectiveness on canine behaviors. Dogs were evaluated and scored using the Evaluation of Dog’s Emotional and cognitive Disorders (EDED) scale and the Canine Behavioral Checklist (CBC) questionnaire at the visits before and after the probiotic treatment. Plasma serotonin levels were measured using high-performance liquid chromatography- electrochemical detection (HPLC-ECD) and the serotonin turnover ratios (5-HIAA/5-HT) were compared pre- and post-treatment. The results showed that the general behavioral stability was improved, and the problems of aggression and separation anxiety were ameliorated after treatment. A significant decrease in 5-HIAA/5-HT ratio was observed in dogs with separation anxiety, suggesting a serotonin-related mechanism. These results proved that PS128 was beneficial for emotional stabilization, which might be useful as a therapeutic supplement for canine aggression and separation anxiety.
Verification watermarks on fingerprint recognition and retrieval (2000)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Reduction of Hot Carrier Effects in Silicon-on-Glass TFTs (2011)

Hot carrier (HC) instability of thin-film transistors (TFTs) fabricated on single-crystal,silicon-on-glass (SiOG) substrates is studied. The formation of the SiOG substrate is achieved by the transfer of a single-crystal silicon film to a display-glass substrate. The transfer process creates an in-situ barrier layer free of mobile ions in the glass adjacent the silicon film. The n- and p-channel TFT transfer characteristics typically exhibit excellent on-state performance with gate voltage swing values of 180 mV/decade, electron and hole mobilities of ∼ 251 and 201 cm2/V·s respectively, and threshold voltages of approximately −0.3 and −1.2 V for the n- and p-channel TFT’s respectively. While p-channel TFTs exhibit good stability, on-current degradation is observed in the transfer characteristics of the n-channel TFT. The degradation is due to HC stress. In this study, the integration of a lightly doped drain (LDD) structure in the n-channel SiOG TFTs to minimize HC instability is reported. The LDD design incorporates 2 μm offset regions. The offset regions are lightly doped (n-) with phosphorus ions implanted at 10 keV. N-levels of ∼ 1 × 1013, 2 × 1013, and 3 × 1013 cm−2 are analyzed to determine the optimum doping conditions that reduce HC instability while minimizing degradation in the on-state device performance.
Volumetric Analysis of the African Elephant Ventricular System (2011)

This study used magnetic resonance imaging (MRI) to determine the volume of the ventricular system in the brain of three adult male African elephants (Loxodonta africana). The ventricular system of the elephant has a volume of ∼240 mL, an order of magnitude larger than that seen in the adult human. Despite this large size, allometric analysis indicates that the volume of the ventricles in the elephant is what one would expect for a mammal with an ∼5 kg brain. Interestingly, our comparison with other mammals revealed that primates appear to have small relative ventricular volumes, and that megachiropterans and microchiropterans follow different scaling rules when comparing ventricular volume to brain mass indicating separate phylogenetic histories. The current study provides context for one aspect of the elephant brain in the broader picture of mammalian brain evolution.
SOS Boosting for Image Deblurring Algorithms (2019)

The work reported by Romano and Elad presents the SOS boosting - a generic recursive method for improving image denoising algorithms. Appealing properties of the SOS scheme are its flexibility to work with any denoising method, its simplicity, and its robustness. In this article we aim to generalize this to the image deblurring task. The proposed SOS procedure for deblurring is given by the following iterative steps: [S]trengthen the signal by blurring the output of the previous iteration and adding it to the blurred input image, [O]perate the deblurring algorithm on the strengthened image, and [S]ubtract the previous output from the current one. We demonstrate this procedure for several state-of-the-art methods (BM3D, EPLL and NCSR), showing the potential gain in output quality for each. As in the original SOS, we manipulate the iterative algorithm by two parameters, better controlling its steady state and rate of convergence.
Development and use of a flexible data harmonization platform to facilitate the harmonization of individual patient data for meta-analyses (2019)

The DHP that we developed (I) allows IPD harmonization with a flexible approach, (II) has the ability to store data in a centralized and secured database server with large capacity, (III) is transparent and easy in use, and (IV) has the ability to export harmonized IPD and corresponding data dictionary to a statistical program. The DHP uses Microsoft Access as front-end application and requires a relational database management system such as Microsoft Structured Query Language (SQL) Server or MySQL as back-end application. The DHP consists of five user friendly interfaces which support the user to import original study data, to harmonize the data with a master data dictionary, and to export the harmonized data into a statistical software program of choice for further analyses. The DHP is now also adopted in two other studies.
Systems Architecture, Design, Engineering, and Verification — The Practice in Research and Research in Practice (2012)

More than any other area in computer science, the interaction and boundary between science and engineering is blurred in the systems area, with cross fertilization from both directions. The systems panel will explore the past, present and future relationship between systems research and engineering practice.
Targeting an Oncolytic Influenza A Virus to Tumor Tissue by Elastase (2017)

Oncolytic viruses are currently established as a novel type of immunotherapy. The challenge is to safely target oncolytic viruses to tumors. Previously, we have generated influenza A viruses (IAVs) containing deletions in the viral interferon antagonist. Those deletions have attenuated the virus in normal tissue but allowed replication in tumor cells. IAV entry is mediated by hemagglutinin (HA), which needs to be activated by a serine protease, for example, through trypsin. To further target the IAV to tumors, we have changed the trypsin cleavage site to an elastase cleavage site. We chose this cleavage site because elastase is expressed in the tumor microenvironment. Moreover, the exchange of the cleavage site previously has been shown to attenuate viral growth in lungs. Newly generated elastase-activated influenza viruses (AE viruses) grew to similar titers in tumor cells as the trypsin-activated counterparts (AT viruses). Intratumoral injection of AE viruses into syngeneic B16f1 melanoma-derived tumors in mice reduced tumor growth similar to AT viruses and had a better therapeutic effect in heterologous human PANC-1-derived tumors. Therefore, the introduction of the attenuation marker "elastase cleavage site" in viral HA allows for safe, effective oncolytic virus therapy.
Verification of Antiparallel G-Quadruplex Structure in Human Telomeres by Using Two-Photon Excitation Fluorescence Lifetime Imaging Microscopy of the 3,6-Bis(1-methyl-4-vinylpyridinium)carbazole Diiodide Molecule (2006)

Different G-quadruplex structures for the human telomeric sequence d(T2AG3)4 in vitro have been documented in the presence of sodium and potassium. Verification of the G-quadruplex structures in human telomeres in vivo is the main issue in establishing the biological function of the G-quadruplex structures in telomeres as well as the development of anticancer agents. Here we have applied two-photon excitation fluorescence lifetime imaging microscopy to measure the fluorescence lifetime of the BMVC molecule upon interaction with various DNA structures. The distinction in lifetime measured with submicrometer spatial resolution in two-photon excitation fluorescence lifetime imaging microscopy provides a powerful approach not only to verify the existence of the antiparallel G-quadruplex structure in human telomeres but also to map its localizations in metaphase chromosomes.
Catalytic Reactions on Li-Doped NiO Using Modulation-Spectroscopy (1974)

The oxidation degree of nickeloxide-electrodes in aqueous solutions depends on the electrode potential, as it is known from the surface of passive nickel-electrodes. In addition to current-potential characteristics and the impedance of the solid state/electrolyte interface this behavior was investigated using modulated reflectance measurements. By modulating the electrode potential this method results in changing the oxidation degree in connection with the optical properties of a surface layer. The investigation of Li-doped (0.5–5 mol%) nickeloxide crystals shows, that the change of the oxidation degree is catalytically influenced by the Li-doping. Measurements of the modulated reflectance result that the electrochemical activity of the doped crystals increases approximately parabolic with rising Li-amount.
Reducing variability among treatment machines using knowledge‐based planning for head and neck, pancreatic, and rectal cancer (2021)

Dosimetric indices of RapidPlan model-based plans appear to be comparable to the ones based on clinical plans regardless of energies, MLC types, and disease sites. The results suggest that the RapidPlan model can generate treatment plans independent of the type of treatment machine.
Supplementary Video 1 from IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development (2023)

&lt;p&gt;AVI file - 1.9MB, 360 degree views of the lungs of a Lox-KrasG12D mouse prior to Ad-cre virus infection. Vasculature is colored red (exterior)/orange (interior) with surrounding lung tissue colored translucent green&lt;/p&gt;
Content-Based Image Retrieval using Metadata and Relaxation Techniques. (1998)

In this chapter, a metadata approach is proposed for content-based image retrieval. A three-layered data model is introduced which consists of a Representation Layer (RL), a Semantic Layer (SL), and a Knowledge Layer (KL). Raw images and segmented objects (represented in contours) are represented in the RL. Hierarchical, spatial, temporal, and evolutionary semantics of the image content are captured in the SL. This layer mimics the user&amp;apos;s conceptual view of the image content. Shape model(s) and decomposition techniques are introduced for extracting features for differently shaped image objects. Knowledge of image feature characteristics is presented in the KL. An instance-based conceptual clustering technique is used to cluster conceptually similar image objects and features. A hierarchical knowledge representation, called type abstraction hierarchy, is used to represent the clustering of similar images based on a common set of features. A knowledge-based spatial evolutionary query lan...
Beginnings (2012)

The mobile phone industry is one which has been characterized by a breathtaking speed of change and development, and anyone who has owned a number of handsets will be aware of the dramatic change evident between a phone of just a few years ago and the latest available models. In order to identify a set of core design issues which hold across generations of handset design, we need to set our sights higher than an analysis of the design of the latest high-end smartphone. We believe a very good place to start is with a review of the relatively short, yet thrilling, history of mobile handsets, providing an opportunity to understand the technological and market issues which have driven this phenomenal development.
Anti-EGF nanobodies enhance the antitumoral effect of osimertinib and overcome resistance in non-small cell lung cancer (NSCLC) cellular models (2022)

Abstract Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is effective against the EGFR T790M mutation in patients with advanced non-small-cell lung cancer (NSCLC). However, acquired resistance appears invariably due to several mechanisms. The strategy of using EGF-targeted nanobodies (Nbs) to block the initial step of the EGFR pathway constitutes a new research area. Nbs offer several advantages compared to traditional mAbs, such as their reduced size, increased stability and tissue penetration, which provide key advantages for targeting soluble tumoral growth factors. In this study we investigated the efficacy of anti-EGF Nbs to reduce Osimertinib resistance. Two anti-EGF Nbs, generated in our laboratory, were shown to inhibit cell viability and colony formation in PC9 and PC9-derived osimertinib-resistant cell lines. The combination of these Nbs with osimertinib improved the antitumoral efficacy of this EGFR-TKI in cell viability and colony formation experiments. In a mechanistic study of the EGFR pathway, the combination treatment dampened the activation of downstream proteins such as Akt and Erk1/2 MAP kinases. In addition, it increased cellular apoptosis and decreased the expression of Hes1, a cancer stem cell marker involved in metastasis and osimertinib resistance. We conclude that the addition of anti-EGF nanobodies enhances the antitumoral properties of osimertinib, thus representing a potentially effective strategy for NSCLC patients.
A tutorial survey on vehicular ad hoc networks (2008)

There has been significant interest and progress in the field of vehicular ad hoc networks over the last several years. VANETs comprise vehicle-to-vehicle and vehicle-to-infrastructure communications based on wireless local area network technologies. The distinctive set of candidate applications (e.g., collision warning and local traffic information for drivers), resources (licensed spectrum, rechargeable power source), and the environment (e.g., vehicular traffic flow patterns, privacy concerns) make the VANET a unique area of wireless communication. This article gives an overview of the field, providing motivations, challenges, and a snapshot of proposed solutions.
Perovskites: Unlocking the Single‐Domain Epitaxy of Halide Perovskites (Adv. Mater. Interfaces 22/2017) (2017)

In article number 1701003, Richard R. Lunt and co-workers demonstrate the controllable epitaxial growth of single-crystal halide perovskites on low cost ionic crystal substrates investigated by in situ real-time diffraction. Such growth is achieved by reactive vapor-phase deposition enabling precise control for tuning epitaxial phases, demonstrating multilayer quantum wells, and providing a new route to uncover the full potential of halide perovskites.
Citric Acid Cycle (2001)

Abstract The citric acid cycle is a metabolic pathway common to aerobic cells by which carbohydrates, fats and amino acids are oxidized to carbon dioxide and water. Enzymes catalyse the condensation of two‐ and four‐carbon compounds to citric acid, and then enzymatic oxidations and decarboxylations regenerate the four‐carbon starting compound plus CO 2 and H 2 O. The energy available from the downhill flow of electrons to oxygen is used indirectly for the synthesis of ATP, the energy currency of the cell.
Supplementary Figure from Immune Infiltrate and Tumor Microenvironment Transcriptional Programs Stratify Pediatric Osteosarcoma into Prognostic Groups at Diagnosis (2023)

Supplementary Figure from Immune Infiltrate and Tumor Microenvironment Transcriptional Programs Stratify Pediatric Osteosarcoma into Prognostic Groups at Diagnosis
Control of the conductivity of Si‐doped β‐Ga2O3 thin films via growth temperature and pressure (2013)

Si‐doped β‐Ga 2 O 3 thin films were grown at temperatures between 400 and 650 °C and oxygen partial pressures ranging from 3 × 10 −4 mbar to 2.4 × 10 −2 mbar prepared by pulsed laser deposition (PLD) on c ‐plane sapphire substrates. For high oxygen partial pressure the samples are composed of multiple crystalline phases; for decreasing oxygen partial pressure the crystallinity improves and single phase ( )‐oriented thin films are obtained for an oxygen partial pressure below at a growth temperature of 650 °C. We find a correlation between surface morphology of our thin films and their conductivity; an increasing root mean square surface roughness entails increased conductivity. Further we show that the oxygen partial pressure resulting in maximal conductivity decreases with increasing growth temperature. The results provide means to realize β‐Ga 2 O 3 ‐based devices such as rectifiers, photodetectors or thin film transistors with optimized surface roughness, structural quality, and conductivity.
Identification of a novel HLA‐DPB1 allele, DPB1*02014, by sequence‐based typing (2002)

In this report we describe the identification of a novel DPB1 allele, DPB1*02014, found in an Italian Caucasian individual. The new allele was detected during routine HLA sequence-based typing (SBT) for an individual undergoing bone marrow transplantation. DPB1*02014 was identical to DPB1*02012 except for a single nucleotide substitution in codon 72 (GTG-->GTT). This nucleotide change represents a synonimous mutation, as both triplets code for a valine. This new allele has been submitted to GenBank and assigned the accession number AF326565. The WHO Nomenclature Committee has officially assigned the name DPB1*02014.