gebhart/patrepeval huggingface dataset:
Impact of Powered and Tissue-Specific Endoscopic Stapling Technology on Clinical and Economic Outcomes of Video-Assisted Thoracic Surgery Lobectomy Procedures: A Retrospective, Observational Study (2018)

Video-assisted thoracic surgery (VATS) lung resections are complex procedures with a critical role played by endoscopic staplers in the transection of vessels, bronchi, and lung tissue. This retrospective, observational study compared hospital resource use, costs, and complications of VATS lobectomy procedures for whom powered versus manual endoscopic surgical staplers were used. Patients ≥ 18 years of age undergoing elective VATS lobectomy during an inpatient admission from January 1, 2012 to September 30, 2016 were identified from the Premier Healthcare Database (first admission = index admission). Use of either powered or manual endoscopic staplers during the index admission was identified from hospital administrative records. Multivariable regression analyses adjusting for patient, hospital, and provider characteristics and hospital-level clustering were carried out to compare the following outcomes between the powered and manual stapler groups: hospital length of stay (LOS), operating room time (ORT), hospital costs, complications (bleeding and/or transfusions, air leak complications, pneumonia, and infection), discharge status, and 30-, 60-, and 90-day all-cause readmissions. The powered and manual stapler groups comprised 659 patients (mean age 66.1 years; 53.6% female) and 3100 patients (mean age 66.7 years; 54.8% female), respectively. In the multivariable analyses, the powered stapler group had shorter LOS (4.9 vs. 5.9 days, P < 0.001), lower total hospital costs ($23,841 vs. $26,052, P = 0.009), and lower rates of combined hemostasis complications (bleeding and/or transfusions; 8.5% vs. 16.0%, P < 0.001) and transfusions (5.4% vs. 10.9%, P = 0.002), compared with the manual stapler group. Other outcomes did not differ significantly between the study groups. Similar trends were observed in subanalyses comparing devices across predominant manufacturers in each group, and in subanalyses of patients with comorbid chronic obstructive pulmonary disease. In this analysis of VATS lobectomy procedures, powered staplers were associated with significant benefits with respect to selected types of hospital resource use, costs, and clinical outcomes when compared with manual staplers. Johnson & Johnson.
Performance Improvement of Radio-Over Fiber Links Using Mixed-Polarization Electro-Absorption Modulators (2011)

We analyze, in theory, simulation, and experiment the spurious-free dynamic range (SFDR) for a radio-over-fiber (RoF) system using a polarization-dependent electro-absorption modulator (EAM) that is linearized using mixed polarization. The mixed-polarization EAM makes use of a polarization-dependent EAM, where a linear polarizer is placed in front of and behind the optical modulator. It is found that improvements of more than 8.1 and 9.5 dB in SDFR for back to back and after 20 km of fiber transmission, respectively, are predicted in theory and simulation and verified experimentally. Suppression of second-order nonlinear distortion is also investigated by simulation and experiment. Moreover, closed forms of the adjacent channel power ratio and third-order intermodulation distortion to carrier power ratio of an orthogonal frequency division multiplexing (OFDM) ultra-wideband (UWB) signal are presented for an RoF link using mixed-polarization EAM. Finally, mixed-polarization EAM is verified for improving the error vector magnitude of the OFDM UWB signal over fiber by more than 3 dB.
Flow Cytometry-Based Apoptosis Detection (2009)

An apoptosing cell demonstrates multitude of characteristic morphological and biochemical features, which vary depending on the stimuli and the cell type. The gross majority of classical apoptotic hallmarks can be rapidly examined by flow and image cytometry. Cytometry thus became a technology of choice in diverse studies of cellular demise. A large variety of cytometric methods designed to identify apoptotic cells and probe mechanisms associated with this mode of cell demise have been developed during the past two decades. In the present chapter, we outline a handful of commonly used methods that are based on the assessment of: mitochondrial transmembrane potential, activation of caspases, plasma membrane alterations and DNA fragmentation.
Use of Sparse and/or Complex Exponents in Batch Verification of Exponentiations. (2005)

Modular exponentiation in an abelian group is one of the most frequently used mathematical primitives in modern cryptography.
ChemInform Abstract: A Novel Ring System Arising from Intramolecular Oxidative Cyclization of 8‐(4‐Pentenyl)dihydroberberine. (1990)

Abstract Berberine chloride (I) is alkenylated with the Grignard compound (II) to form the derivative (III) which undergoes oxidation and intramolecular cycloaddition reaction upon recrystallization, yielding the polycyclic derivative (IV).
Next-Generation Complex Metal Oxide Nanomaterials Negatively Impact Growth and Development in the Benthic Invertebrate Chironomus riparius upon Settling (2019)

Most studies of nanomaterial environmental impacts have focused on relatively simple first-generation nanomaterials, including metals or metal oxides (e.g., Ag, ZnO) for which dissolution largely accounts for toxicity. Few studies have considered nanomaterials with more complex compositions, such as complex metal oxides, which represent an emerging class of next-generation nanomaterials used in commercial products at large scales. Importantly, many nanomaterials are not colloidally stable in aqueous environments and will aggregate and settle, yet most studies use pelagic rather than benthic-dwelling organisms. Here we show that exposure of the model benthic species Chironomus riparius to lithium cobalt oxide (Li <sub>x</sub>Co<sub>1- x</sub>O<sub>2</sub>, LCO) and lithium nickel manganese cobalt oxide (Li <sub>x</sub>Ni <sub>y</sub>Mn <sub>z</sub>Co<sub>1- y- z</sub>O<sub>2</sub>, NMC) at 10 and 100 mg·L<sup>-1</sup> caused 30-60% declines in larval growth and a delay of 7-25 d in adult emergence. A correlated 41-48% decline in larval hemoglobin concentration and related gene expression changes suggest a potential adverse outcome pathway. Metal ions released from nanoparticles do not cause equivalent impacts, indicating a nanospecific effect. Nanomaterials settled within 2 days and indicate higher cumulative exposures to sediment organisms than those in the water column, making this a potentially realistic environmental exposure. Differences in toxicity between NMC and LCO indicate compositional tuning may reduce material impact.
ChemInform Abstract: Highly Stereoselective and Scalable Synthesis of trans‐Fused Octahydrocyclohepta[b]pyrrol‐4(1H)‐ones via the Aza‐Cope—Mannich Rearrangement in Racemic and Enantiopure Forms. (2013)

Abstract Key steps of the process are the regioselective epoxide ring‐opening of alkynyl oxirane (I) and stereoselective aza‐Cope—Mannich reaction.
Molecular structures of gaseous trifluoro(methyl)sulfurane, CH3SF3, and trifluoro(trifluoromethyl)sulfurane, CF3SF3: experimental determination by electron diffraction and ab initio calculations (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular structures of gaseous trifluoro(methyl)sulfurane, CH3SF3, and trifluoro(trifluoromethyl)sulfurane, CF3SF3: experimental determination by electron diffraction and ab initio calculationsAnthony J. Downs, G. Sean McGrady, Elizabeth A. Barnfield, David W. H. Rankin, Heather E. Robertson, James E. Boggs, and Kerwin D. DobbsCite this: Inorg. Chem. 1989, 28, 17, 3286–3292Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ic00316a008https://doi.org/10.1021/ic00316a008research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Resonant Ultrasound Spectroscopy: theory and application (2003)

Resonant Ultrasound Spectroscopy (RUS) uses normal modes of elastic bodies to infer material properties such as elastic moduli and Q. In principle, the complete elastic tensor can be inferred from a single measurement. For centimeter-sized samples RUS fills an experimental gap between low-frequency stress-strain methods (quasi-static up to a few kHz) and ultrasonic time-delay methods (hundreds of kHz to GHz). We use synchronous detection methods to measure the resonance spectra of homogeneous rock samples. These spectra are then fit interactively with a model to extract the normal-mode frequencies and Q factors. Inversion is performed by fitting the normal-mode frequencies. We have successfully applied this technique to a variety of isotropic and anisotropic samples, both man-made and natural. In this paper we will show in detail the procedure applied to a cylindrical core of Elberton granite. By means of a statistical fit of the measured normal modes and an independent laser ultrasonic measurement, the granite core was inferred to have orthorhombic symmetry. A 10 per cent P-wave anisotropy was measured in the plane perpendicular to the core axis.
Impact of fiber Bragg grating based OADM outband dispersion in DWDM-SCM systems (2002)

In this letter, we analyze the effect of the fiber Bragg grating-based optical add-drop multiplexers outband dispersion on bypassed adjacent channels to the dropped channel when it is carrying subcarrier modulated signals. The results show a potential limitation in terms of additional harmonic and intermodulation distortion.
Loss of range of motion of the hip joint: a hypothesis for etiology of sports hernia (2015)

the study highlights observation of limitation of hip rotation with the hip flexed to 90 degrees as a possible factor in the aetiology of sports hernia. There may be an association with other pathologies of the hip such as impingement that requires further investigation. Though this study has its limitation in being a small number and a case control study, it does helps in understanding the possible mechanism of development of this condition.
Effect of transcutaneous auricular vagus nerve stimulation on impaired glucose tolerance: a pilot randomized study (2014)

Our study suggests that taVNS is a promising, simple, and cost-effective treatment for IGT/ pre-diabetes with only slight risk of mild side-effects.
A style-aware architectural middleware for resource-constrained, distributed systems (2005)

A recent emergence of small, resource-constrained, and highly mobile computing platforms presents numerous new challenges for software developers. We refer to development in this new setting as programming-in-the-small-and-many (Prism). This paper provides a description and evaluation of Prism-MW, a middleware platform intended to support software architecture-based development in the Prism setting. Prism-MW provides efficient and scalable implementation-level support for the key aspects of Prism application architectures, including their architectural styles. Additionally, Prism-MW is extensible to support different application requirements suitable for the Prism setting. Prism-MW has been applied in a number of applications and used as an educational tool in graduate-level software architecture and embedded systems courses. Recently, Prism-MW has been successfully evaluated by a major industrial organization for use in one of their key distributed embedded systems. Our experience with the middleware indicates that the principles of architecture-based software development can be successfully, and flexibly, applied in the Prism setting.
High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias (2007)

Fatty acids are implicated in the development of dyslipidemias, leading to type 2 diabetes and cardiovascular disease. We used a standardized small compound library to screen humanized yeast to identify compounds that inhibit fatty acid transport protein (FATP)-mediated fatty acid uptake into cells. This screening procedure used live yeast cells expressing human FATP2 to identify small compounds that reduced the import of a fluorescent fatty acid analog, 4,4-difluoro-5-methyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoic acid (C(1)-BODIPY-C(12)). The library used consisted of 2,080 compounds with known biological activities. Of these, approximately 1.8% reduced cell-associated C(1)-BODIPY-C(12) fluorescence and were selected as potential inhibitors of human FATP2-mediated fatty acid uptake. Based on secondary screens, 28 compounds were selected as potential fatty acid uptake inhibitors. Some compounds fell into four groups with similar structural features. The largest group was structurally related to a family of tricyclic, phenothiazine-derived drugs used to treat schizophrenia and related psychiatric disorders, which are also known to cause metabolic side effects, including hypertriglyceridemia. Potential hit compounds were studied for specificity of interaction with human FATP and efficacy in human Caco-2 cells. This study validates this screening system as useful to assess the impact of drugs in preclinical screening for fatty acid uptake.
HETEROGENEITY OF ACETYLCHOLINESTERASE IN NEUROBLASTOMA (1976)

Abstract– Multiple forms of acetylcholine hydrolyzing activity have been observed in Triton X‐100 treated homogenates of mouse neuroblastoma cells. All these forms appear to be the true acetylcholinesterase, AChE (EC 3.1.17): they are substrate‐inhibited; hydrolyze acetylcholine &gt; acetyl‐β‐methylcholine ≫ butrylcholine and are preferentially inhibited by specific AChE inhibitors. Almost all of the cell AChE activity is membrane associated, but readily ‘solubilized’ by Triton X‐100 and as such appears free of membrane contamination. With the aid of affinity chromatography the ‘solubilized’ neuroblastoma AChE has been partially purified (490‐fold) to a specific activity of 34,300 nmol/min/mg protein. Four active neuroblastoma AChE species appear upon acrylamide gel electrophoresis (with MWs of 64,000; 116,000; 186,000 and 284,000) while three species (4S, 6S and 9.6S) have been found upon sucrose gradient sedimentation analysis. We have determined that the 4S form migrates on acrylamide as the 116,000 MW species and the 9.6S form contains, in equal amounts, the 186,000 and 284,000 MW acrylamide species. Numerous active AChE forms are seen on Sepharose 6B chromatography. From comparing the crude, 4S, 9.6S and partially purified AChEs on acrylamide gels, sucrose gradients and Sepharose, mouse neuroblastoma appears to contain active AChE units which are capable of multiple types of dissociation and reassociation. An attempt is made to correlate all the observed AChE forms as well as relate this data to that known about AChE obtained from other sources.
Uterine artery embolization immediately preceding laparoscopic myomectomy (2011)

UAE performed immediately before laparoscopic myomectomy facilitated minimally invasive surgery for larger uteri and larger uterine myomas, with no differences in operative time or blood loss.
A novel particle source based on electrospray charging for dust accelerators and its significance for cosmic dust studies (2013)

In situ cosmic dust analyzers, like those aboard Cassini, Galileo, and Stardust, provide important data about cosmic dust, including the chemical composition of dust particles. Correctly interpreting the data from these cosmic dust analyzers requires laboratory calibration experiments. By studying the impact mass spectrum from a particle of known composition, an unknown particle’s composition can be inferred from its impact mass spectrum measured in situ. This work expands a recently presented method, electrospray charging, introduced as a means of charging minerals, astrophysical ices, and mineral-ice mixtures that are not electrically conductive. This overcomes a limitation of current dust accelerators: they can only charge, and therefore accelerate, electrically conductive particles. This paper presents experiments demonstrating that microparticles (typically 2 micrometers) of olivine, a common mineral in meteorites, and of an ordinary chondrite (Allan Hills A 79045) can be electrically charged even though neither is electrically conductive. This article discusses the acceleration potential of electrospray-charged projectiles, and explores ways to overcome the challenges implicit in coupling an electrospray source to a dust accelerator. Electrospray charging may enable experiments with novel projectiles that are better analogues for cosmic dust than the conductive projectiles currently in use. Theoretical charging limits using this technique would allow micron-sized particles to be accelerated to several km/s using 3 MV potential, with higher velocities for smaller particles.
Highly Regioselective Arylation of sp3 C−H Bonds Catalyzed by Palladium Acetate (2005)

A new palladium-catalyzed arylation process based on C-H activation has been developed. The utilization of pyridine-containing directing groups allows the beta-arylation of carboxylic acid derivatives and gamma-arylation of amine derivatives. Both primary and secondary sp3 C-H bonds, as well as sp2 C-H bonds, are reactive.
Extracellular Matrix‐Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin‐Like Polypeptide Hydrogels (2021)

Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)-mimetic hydrogels are of particular interest as regenerative scaffolds for the injured nervous system as they provide 3D bioactive interfaces that modulate cellular response to the injury environment and provide naturally degradable scaffolding for effective tissue remodeling. In this review, three unique ECM-mimetic hydrogels used in models of neural injury are reviewed: fibrin hydrogels, which rely on a naturally occurring enzymatic gelation, hyaluronic acid hydrogels, which require chemical modification prior to chemical crosslinking, and elastin-like polypeptide (ELP) hydrogels, which exhibit a temperature-sensitive gelation. The hydrogels are reviewed by summarizing their unique biological properties, their use as drug depots, and their combination with other biomaterials, such as electrospun fibers and nanoparticles. This review is the first to focus on these three ECM-mimetic hydrogels for their use in neural tissue engineering. Additionally, this is the first review to summarize the use of ELP hydrogels for nervous system applications. ECM-mimetic hydrogels have shown great promise in preclinical models of neural injury and future advancements in their design and use can likely lead to viable treatments for patients with neural injury.
An Online Learning Algorithm for Neuromorphic Hardware Implementation (2015)

We propose a sign-based online learning (SOL) algorithm for a neuromorphic hardware framework called Trainable Analogue Block (TAB). The TAB framework utilises the principles of neural population coding, implying that it encodes the input stimulus using a large pool of nonlinear neurons. The SOL algorithm is a simple weight update rule that employs the sign of the hidden layer activation and the sign of the output error, which is the difference between the target output and the predicted output. The SOL algorithm is easily implementable in hardware, and can be used in any artificial neural network framework that learns weights by minimising a convex cost function. We show that the TAB framework can be trained for various regression tasks using the SOL algorithm.
Primary Structural Analysis of the Transplantation Antigens of the Murine H-2 Major Histocompatibility Complex (1981)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Hybrid TiO2 Solar Cells Produced from Aerosolized Nanoparticles of Water-Soluble Polythiophene Electron Donor Layer (2014)

Hybrid solar cells (HSCs) with water soluble polythiophene sodium poly[2-(3-thienyl)-ethyloxy-4-butylsulfonate] (PTEBS) thin films produced using electrospray deposition (ESD) were fabricated, tested, and modeled and compared to devices produced using conventional spin coating. A single device structure of FTO/TiO 2 /PTEBS/Au was used to study the effects of ESD of the PTEBS layer on device performance. ESD was found to increase the short circuit current density (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>J</mml:mi></mml:mrow><mml:mrow><mml:mtext>sc</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>) by a factor of 2 while decreasing the open circuit voltage (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:msub><mml:mrow><mml:mi>V</mml:mi></mml:mrow><mml:mrow><mml:mtext>oc</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>) by half compared to spin coated PTEBS films. Comparable efficiencies of 0.009% were achieved from both device construction types. Current-voltage curves were modeled using the characteristic solar cell equation and showed a similar increase in generated photocurrent with an increase by two orders of magnitude in the saturation current in devices from ESD films. Increases in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:msub><mml:mrow><mml:mi>J</mml:mi></mml:mrow><mml:mrow><mml:mtext>sc</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math> are attributed to an increase in the interfacial contact area between the TiO 2 and PTEBS layers, while decreases in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mrow><mml:msub><mml:mrow><mml:mi>V</mml:mi></mml:mrow><mml:mrow><mml:mtext>oc</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math> are attributed to incomplete film formation from ESD.
Studies of architecture of MoO3–TiO2 catalysts (1988)

X-Ray diffraction, F.t.i.r., scanning electron microscopy (SEM) and ion-scattering spectroscopy (ISS) have been applied to characterize a series of MoO3–TiO2(anatase) samples prepared by the grafting and impregnation methods. The sample prepared with the grafting method exhibits good dispersion of MoO3, whereas the impregnation technique leads to a poorer dispersion of molybdena on the surface of titania. The poorer dispersion of MoO3 is due to the clustering of molybdena when the MoO3 loading does not exceed the theoretical monolayer coverage (6.3 wt% MoO3). At higher MoO3 loading, crystals of MoO3 of morphology different from pure MoO3 crystals, appear. A possible explanation of this phenomenon is discussed.
A Remarkable Iodine‐Catalyzed Protection of Carbonyl Compounds. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.