gebhart/patrepeval huggingface dataset:
Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme (2005)

Early growth and differentiation of the pancreatic endoderm is regulated by soluble factors from the pancreatic mesenchyme. Previously, we demonstrated that N-cadherin-deficient mice lack a dorsal pancreas, due to a critical role of N-cadherin in dorsal pancreatic mesenchymal cell survival. Here, we show that restoring cardiac and circulatory function in N-cadherin null mice by cardiac-specific expression of N-cadherin, rescues formation of the dorsal pancreas, indicating that the phenotype is secondary to defects related to cardiac/vascular function. Based on this observation, we demonstrate that soluble factors present in plasma, such as sphingosine-1-phosphate, rescue formation of the dorsal pancreas in N-cadherin-deficient mice. We also show that sphingosine-1-phosphate indirectly promotes budding of the pancreatic endoderm by stimulating pancreatic mesenchymal cell proliferation. Finally, we identify sphingosine-1-phosphate receptors within the mesenchyme and show that pertussis toxin blocks the sphingosine-1-phosphate-induced actions, suggesting the involvement of G-protein-coupled sphingosine-1-phosphate receptors. Thus, we propose a new model where blood vessel-derived sphingosine-1-phosphate stimulates growth and budding of the dorsal pancreatic endoderm by induction of mesenchymal cell proliferation.
Unlocking the Potential of Fluoride-Based Solid Electrolytes for Solid-State Lithium Batteries (2019)

The development of high energy density and sustainable all-solid-state lithium batteries relies on the development of suitable Li+ transporting solid electrolytes with high chemical and electrochemical stability, good interfacial compatibility, and high ionic conductivity. Ceramic-based electrolytes show high bulk Li+ conductivity and stability but exhibit poor mechanical properties. In contrast, a few sulfide-based electrolytes show high total Li+ conductivity and better mechanical properties but poor chemical and electrochemical stability. Moreover, both types of electrolytes exhibit interfacial compatibility issues with several electrode materials. Here, we reveal the potential of Li-containing metal fluorides as Li+ conducting solid electrolytes for solid-state lithium batteries, demonstrating their viability with a case study on β-Li3AlF6. We have synthesized β-Li3AlF6 by mechanical milling and investigated its properties as a solid electrolyte. An ionic conductivity of 3.9 × 10–6 S cm–1 was observed at 100 °C, which was increased to 1.8 × 10–5 S cm–1 by compositing with nanocrystalline alumina (γ-Al2O3). Furthermore, the performance of β-Li3AlF6 as a solid electrolyte was successfully tested in an all-solid-state lithium battery by using LiMn2O4 as a cathode and Li metal as an anode. Finally, we have used density functional theory to shed light on the Li diffusion pathways and associated activation barriers in β-Li3AlF6. Overall, our studies reveal the hidden potential of Li-containing metal fluorides as solid electrolytes for all-solid-state lithium batteries.
Evaluation of switching frequency modulation in EMI emissions reduction applied to power converters (2004)

Although most of the power converters are currently designed to operate by using a constant switching frequency and a variable duty-cycle, some attempts were made in order to verify the effect of modulating the switching frequency [F. Lin et al., 1992] and how this modulation affected the power converters EMI emissions. As known, spread spectrum clock generation (SSCG) modulates the originally constant switching frequency by following a certain modulation profile in order to spread the single harmonic energy into an amount of side-band harmonics having the same energy but much smaller amplitudes. This reduction technique has been used and implemented for high frequencies (as those related to clock frequencies in communications and microprocessors systems). This paper is dedicated to SSCG applied to the reduction of EMI emissions in power converters, focusing on the effectiveness of frequency modulation in EMI reduction as a function of the different switching frequency ranges and modulation profiles. Theoretical results were obtained just modulating a sine pure wave following several modulation profiles [A. Santolaria et al., 2002], this one representing each one of the harmonics composing the real square PWM-signal controlling the power converter. A practical arrangement was implemented to generate and measure EMI emissions.
MiR-876-3p targets KIF20A to block JAK2/STAT3 pathway in glioma. (2019)

Aberrant expression of miRNAs has been reported to be involved in the development and progression of glioma. But the function of miR-876-3p in glioma is unknown. We found that miR-876-3p is significantly downregulated in glioma tissues and cell lines. Overexpression of miR-876-3p suppressed glioma cell proliferation, epithelial-mesenchymal transition, migration, and invasion. By prediction combining with luciferase reporter assay, we identified that miR-876-3p could decrease the expression of KIF20A by directly targeting the region of its 3'UTR. Furthermore, we observed that overexpression of miR-876-3p inhibited the expression of KIF20A, thus blocking the protein kinase JAK2/STAT3 pathway. Overexpressed KIF20A reversed miR-876-3p-induced suppression of glioma cell proliferation, migration, and invasion. We also demonstrated the inhibitory effect of miR-876-3p on tumor growth in glioma using an in vivo model. The miR-876-3p/KIF20A-axis mediated JAK2/STAT3 pathway have therapeutic potential in glioma treatment.
ChemInform Abstract: Toward the Development of a General Chiral Auxiliary. Evaluation of Camphor Lactam Imide Auxiliaries for Asymmetric Aldol Reactions. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Secure and Privacy Friendly 2D+3D Face Authentication System Robust Under Pose and Illumation Variation (2007)

An end-to-end face authentication system integrating 2D color images and depth data is presented in this paper, based on a low-cost sensor capable of real-time acquisition of 3D images and associated color images. Depth data is used for robust face detection, localization and 3D pose estimation, as well as for compensating pose and illumination variations of facial images prior to classification. The performance of the proposed system is tested on an extended face database recorded in real-world conditions, while a complete security and privacy analysis is conducted in order to ensure that all necessary countermeasures are built into the system.
Airway hyperreactivity: assessment with helical thin-section CT. (1998)

Functional helical CT can accurately demonstrate reversible airflow obstruction resulting from airway hyperreactivity.
A randomized, blinded, placebo-controlled trial of recombinant human tissue-type plasminogen activator in patients with unstable angina pectoris. (1987)

Twenty-four patients with unstable angina pectoris, defined as chest pain at rest with transient ST segment deviation of at least 1 mm, were randomly assigned to blinded treatment with either placebo or intravenous recombinant human tissue-type plasminogen activator (rt-PA). Before randomization, all patients were treated with oral beta-blockers, calcium antagonists, nitrates, and continuous intravenous heparin for a monitoring period of 12 to 28 hr. After this monitoring period the 24 patients were randomly assigned to receive either placebo or 1.75 mg/kg intravenous rt-PA given over 12 hr at a rate of 0.75 mg/kg over 1 hr, 0.5 mg/kg over 4 hr, and 0.5 mg/kg over 7 hr. One patient, assigned to receive placebo, developed acute myocardial infarction after randomization but before receiving the study drug. Ischemic events were recorded during a hospital follow-up period of at least 4 days unless a further intervention was indicated or the coronary angiogram was normal. The follow-up period was 7 +/- 5 days (mean +/- SD) after the placebo infusion and 8 +/- 4 days after the infusion of rt-PA. Unstable angina pectoris persisted after the completion of the infusion in six of 11 patients receiving placebo and only one of 12 patients receiving rt-PA (p less than .03). Coronary angiography, performed 38 +/- 19 hr after the infusion, demonstrated subocclusive thrombus in eight of 11 patients receiving placebo but in none of 11 patients treated with rt-PA (p less than .002). One patient on rt-PA refused coronary angiography.(ABSTRACT TRUNCATED AT 250 WORDS)
Microbiological Examination of Bandage Soft Contact Lenses Used in Laser Refractive Surgery (1998)

Contamination was independent of the surgical procedure and females who were frequent users of eyelid cosmetics displayed higher contamination frequencies, suggesting that bacteria possibly originate from eyelid flora. The isolation of Staphylococcus epidermidis requires close postoperative surveillance, since it is a known cause of keratitis. Prophylactic postoperative treatment with tobramycin, gentamycin, or sulphonamides could be indicated.
ANAEROBIC AND AEROBIC BACTERIOLOGY OF THE SALIVA AND GINGIVA FROM 16 CAPTIVE KOMODO DRAGONS (VARANUS KOMODOENSIS): NEW IMPLICATIONS FOR THE “BACTERIA AS VENOM” MODEL (2013)

It has been speculated that the oral flora of the Komodo dragon (Varanus komodoensis) exerts a lethal effect on its prey; yet, scant information about their specific oral flora bacteriology, especially anaerobes, exists. Consequently, the aerobic and anaerobic oral bacteriology of 16 captive Komodo dragons (10 adults and six neonates), aged 2-17 yr for adults and 7-10 days for neonates, from three U.S. zoos were studied. Saliva and gingival samples were collected by zoo personnel, inoculated into anaerobic transport media, and delivered by courier to a reference laboratory. Samples were cultured for aerobes and anaerobes. Strains were identified by standard methods and 16S rRNA gene sequencing when required. The oral flora consisted of 39 aerobic and 21 anaerobic species, with some variation by zoo. Adult dragons grew 128 isolates, including 37 aerobic gram-negative rods (one to eight per specimen), especially Enterobacteriaceae; 50 aerobic gram-positive bacteria (two to nine per specimen), especially Staphylococcus sciuri and Enterococcusfaecalis, present in eight of 10 and nine of 10 dragons, respectively; and 41 anaerobes (one to six per specimen), especially clostridia. All hatchlings grew aerobes but none grew anaerobes. No virulent species were isolated. As with other carnivores, captive Komodo oral flora is simply reflective of the gut and skin flora of their recent meals and environment and is unlikely to cause rapid fatal infection.
Enable Communications Between The RSW Control Criteria and SIP Using R2SP (2006)

Various standards organizations have considered signaling for voice and video over IP from different approaches. There are currently more than one standard for signaling and control of Internet telephone calls. Some of them, which widely used are RSW control protocol and the IETF session initiation protocol (SIP). Both protocols provide comparable functionality using different mechanisms and provide similar quality of service. Although there are numerous industry debates about the merits of the two protocols, the truth is that both of them, along with other complementary protocols, are necessary to provide universal access and to support IP-based enhanced services. Both protocols have been widely deployed, so interworking between RSW and SIP is essential to ensure full end-to-end connectivity. Because of the inherent differences between RSW and SIP, accommodation must be made to allow interworking between the two protocols. The work reported in this paper proposes a communication translation protocol to bridge the RSW control protocol and SIP control protocol. This communication translation protocol has to provide a set of rules to enable communications between the RSW control criteria and SIP standards. The communication translation entity defined can be called translator server
Intragastric balloon in the treatment of patients with morbid obesity (2001)

The IGB represents a useful device for the treatment of morbid obesity, particularly in preparation for definitive antiobesity procedures. Early IGB replacement is essential to minimize complications.
Turbo coded modulation for wireless communications with antenna diversity (2000)

We introduce turbo coded modulation for wireless communication systems with transmit and receive antenna diversity. We describe a simple way of applying turbo coded modulation to multiple antenna systems. We present examples to illustrate the performance of the turbo coded modulation scheme and observe significant performance gains over the appropriately interleaved space-time trellis codes.
Blood pressure variability and prognosis in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis (2021)

The blood pressure variability (mean and minimum systolic blood pressure) is a good predictor and parameter in the aneurysmal subarachnoid hemorrhage prognosis and outcome prediction.
Rare earth metals used in biodegradable magnesium‐based stents do not interfere with proliferation of smooth muscle cells but do induce the upregulation of inflammatory genes (2008)

Rare earth metals are added to corrodible magnesium-based alloys in low amounts (up to 10%) to improve their mechanical properties and to decrease the degradation rate. Cerium (Ce), neodymium (Nd), yttrium (Y), and ytterbium (Yb) are already used for degradable cardiovascular stents. Little is known about the biocompatibility of rare earth metals released during the degradation process of the implant. Therefore the biocompatibility of rare earth metals was assessed with regard to metabolic activity of human vascular smooth muscle cells (SMCs). After coincubation with the trivalent chlorides (0.5-100 microg/mL) of rare earth metals for 24, 72, 144, and 240 h metabolic activity was determined at each time point using the colometric WST-1 test. The tested rare earth metals did not lead to significant changes in metabolic activity over a wide concentration range. However, at high concentrations a decrease was observed. Apoptotic or necrotic effects were not observed. Furthermore, we analyzed the effects of Ce, Nd, Y, and Yb on the expression of genes involved in inflammatory processes. The expression of IL-6, IL-8, and ICAM-1 in SMCs after exposure to Ce, Nd, Y, and Yb (5 and 50 microg/mL) was measured using quantitative real-time PCR. Significant up-regulation of IL-6, IL-8, and ICAM-1 genes were only found after 24 h, mainly for a concentration of 50 microg/mL. Our cell culture data indicate that rare earth metals influence cellular processes of vascular cells. Whether adverse effects occur also in in vivo is the topic of further investigations.
Temporal characterization of plasma wakefields driven by intense femtosecond laser pulses (1997)

Because electrostatic fields in a plasma wave ( E ≥ 100 GV/m) can exceed by three orders of magnitude those in conventional RF linacs, plasma based accelerators can potentially offer a compact method for accelerating high energy electrons. Of the several methods for driving large amplitude plasma waves, the laser wakefield accelerator (LWFA) and its variant, the self-modulated LWFA, have recently received considerable attention because of the reduction in size of the terawatt class laser systems needed to drive the wakefield [1]. In this paper, we demonstrate all optical techniques based on frequency domain interferometry [2] and forward, collective Thomson scattering [3] for temporal characterization of the plasma wakefield. The ability to measure the plasma wake temporal structure is of fundamental importance for a number of issues, including: wakefield generation by optimized pulse trains, the design of particle injectors synchronized to the wakefield on a femtosecond time scale, and the growth dynamics of plasma wave instabilities.
Designing a resource broker for heterogeneous grids (2007)

Abstract Grids provide uniform access to aggregations of heterogeneous resources and services such as computers, networks and storage owned by multiple organizations. However, such a dynamic environment poses many challenges for application composition and deployment. In this paper, we present the design of the Gridbus Grid resource broker that allows users to create applications and specify different objectives through different interfaces without having to deal with the complexity of Grid infrastructure. We present the unique requirements that motivated our design and discuss how these provide flexibility in extending the functionality of the broker to support different low‐level middlewares and user interfaces. We evaluate the broker with different job profiles and Grid middleware and conclude with the lessons learnt from our development experience. Copyright © 2007 John Wiley &amp; Sons, Ltd.
Development of nanosomes using high-pressure homogenization for gene therapy (2010)

To conclude, these results indicate that condensing pDNA with PS followed by subsequent complexation with low-concentration nanosomes generated from HPH can produce a pDNA nanosome formulation that will boost transfection efficiency, while minimizing cytotoxicity. This new technology appears to be an efficient tool for future commercial or large-scale manufacture of DNA delivery systems for gene therapy.
Early Androgen Deficiency in Infants and Young Boys with 47,XXY Klinefelter Syndrome (2005)

The physical phenotype in infants and young boys with KS (1-23 months old) includes normal auxologic measurements and early evidence of testicular failure. Muscle tone was decreased in most of the boys. Testicular volume and penile length were diminished, indicating early androgen deficiency. The neonatal surge in testosterone was attenuated in our KS population. Thus, infants and young boys with KS have evidence of early testicular failure. The etiology of this failure and the clinical role of early androgen replacement require further study.
Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound (2007)

Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized Pluronic P105 micelles, Pluronic P105 micelles stabilized with an interpenetrating network of N,N-diethylacrylamide, and micelles of poly(ethylene oxide)-b-poly (N-isopropylacrylamide)-b-poly(oligolactylmethacrylate) with stabilized cores. An ultrasonic exposure chamber with fluorescence detection was used to measure the release of the antineoplastic agent from both stabilized and unstabilized micelles. The release of Dox at 37 degrees C from unstabilized Pluronic appears to be several times higher than release from the more stabilized and crosslinked copolymers at the same temperature. Although there is a difference in the amount of release between the different compounds, the onset of release occurs at about the same ultrasonic power density for all carriers investigated in this study. The threshold of drug release for all the compounds correlates to the emergence of subharmonic peaks detected in the acoustic spectra. We hypothesize that shearing events caused by cavitating bubbles play an important role in the acoustically activated release of chemotherapy agents delivered from various polymeric drug delivery vehicles.
Crystal structure of 2-amino-4-(3,4,5-trifluorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile, C16H11F3N2O2 (2016)

Abstract C 16 H 11 F 3 N 2 O 2 , triclinic, P 1̅ (No. 2), a = 8.3288(5) Å, b = 8.6385(8) Å, c = 11.6004(8) Å, α = 111.488(7)°, β = 94.705(6)°, γ = 99.107(6)°, V = 757.87(10) Å 3 , Z = 2, R gt (F) = 0.0435, wR ref (F 2 ) = 0.0954, T = 293(2) K.
Pitfalls in the emergency department triage of frail elderly patients without specific complaints (2005)

Frail elderly patients admitted without specific complaints are at risk of inappropriate or delayed evaluation due to undertriage at the door of the ED. A more specific geriatric assessment should be integrated early in the triage process of these patients.
A useful technique for the control of severe cesarean hemorrhage: report of three cases. (2002)

When we are confronted with a patient experiencing placenta previa with massive hemorrhage in cesarean delivery, hemostasis is first attempted using uterotonic drugs, uterine massage, and intrauterine packing. However, if these maneuvers fail, then uterine artery ligation, whole myometrial suture, and subendometrial vasopressin injection should be attempted. Perhaps these procedures alone or in combination can successfully control the hemorrhage. Every obstetrician must be familiar with these simple methods in order to avoid having to perform a hysterectomy and thus preserving the reproductive capability, as well as diminishing the operative morbidity. Finally, we described a full thickness suture for the placental site of bleeding for the lower uterine segment.
Why Prodrugs and Propesticides Succeed (2017)

What are the advantages of bioactivation in optimizing drugs and pesticides? Why are there so many prodrugs and propesticides? These questions are examined here by considering compounds selected on the basis of economic value or market success in 2015. The 100 major drugs and 90 major pesticides are divided into ones acting directly and those definitely or possibly requiring bioactivation. Established or candidate prodrugs accounted for 19% of the total drug sales, with corresponding values of 20, 37, and 17% for proinsecticides, proherbicides, and profungicides. The 19 prodrugs acting in humans generally had better pharmacodynamic/pharmacokinetic properties for target enzyme, receptor, tissue, or organ specificity due to their physical properties (lipophilicity and stabilization). Bioactivation usually involved hydrolases or cytochrome P450 oxidation or reduction. Prodrugs considered are neuroactive aripiprazole, eletriptan, desvenlafaxin, lisdexamfetamine, quetiapine, and fesoterodine; cholesterol-lowering atorvastatin, ezetimibe, and fenofibrate; various prodrugs activated by esterases or sulfatases, ciclesonide, oseltamivir, dabigatran; omega-3 fatty acid ethyl esters and esterone sulfate; and five others with various targets (sofosbuvir, fingolimod, clopidogrel, dapsone, and sildenafil). The proinsecticides are the neuroactive chlorpyrifos, thiamethoxam, and indoxacarb, two spiro enol ester inhibitors of acetyl CoA carboxylase (ACCase), and the bacterial protein delta-endotoxin. The proherbicides considered are five ACCase inhibitors including pinoxaden and clethodim, three protox inhibitors (saflufenacil, flumioxazin, and canfentrazone-ethyl), and three with various targets (fluroxypyr, isoxaflutole, and clomazone). The profungicides are prothioconazole, mancozeb, thiophanate-methyl, dazomet, and fosetyl-aluminum. The prodrug and propesticide concept is broadly applicable and has created some of the most selective pharmaceutical and pest control agents, illustrated here by major compounds that partially overcome pharmacokinetic limitations of potency and selectivity in the corresponding direct-acting compounds. The challenges of molecular design extend beyond the target site fit to the bioactivatable precursor and the fascinating chemistry and biology matched against the complexity of life processes.
Common cold and high-dose ipratropium bromide: use of anticholinergic medication as an indicator of reflex-mediated hypersecretion. (1997)

(1) during the first days of a common cold about 60% of the nasal discharge is a reflex-mediated product from nasal glands; (2) this type of secretion is predominantly watery; and (3) ipratropium bromide can reduce watery rhinorrhoea in the common cold, but a lower dose is required in order to avoid side effects.