gebhart/patrepeval huggingface dataset:
The Design of the S2 Control Charts Based on Conditional Performance via Exact Methods (2017)

In this paper, we consider the conditional performance of the equal‐tailed and average run lengths (ARL)‐unbiased two‐sided S 2 charts when the in‐control variance of a normal process is estimated. We derive the exact probability distributions of the conditional ARL for the two S 2 charts. Then we evaluate the performance of each S 2 chart in terms of the percentiles, mean and standard deviation of the conditional in‐control ARL distribution. Because the parameter estimation seriously affects the conditional performance of these S 2 charts, we propose an exact method to design the equal‐tailed and ARL‐unbiased S 2 charts with desired conditional in‐control performance. The results indicate that the new ARL‐unbiased S 2 chart has far smaller standard deviation ARL values and the unconditional ARL values are more close to the desired value than the corresponding new equal‐tailed S 2 chart. Copyright © 2017 John Wiley &amp; Sons, Ltd.
AUTO-GENERATION OF PROGRAMMING EXERCISES FOR EDUCATION OF MPI AND AVX PARALLEL PROGRAMMING (2023)

Appears in: INTED2023 Proceedings Publication year: 2023Pages: 841-849ISBN: 978-84-09-49026-4ISSN: 2340-1079doi: 10.21125/inted.2023.0261Conference name: 17th International Technology, Education and Development ConferenceDates: 6-8 March, 2023Location: Valencia, Spain
Isolation and Characterization of Neurogenic Mesenchymal Stem Cells in Human Scalp Tissue (2005)

Recent studies have shown that adult tissues contain stem/ progenitor cells capable of not only generating mature cells of their tissue of origin but also transdifferentiating themselves into other tissue cells. Murine skin-derived precursor cells, for example, have been described as unique, nonmesenchymal-like stem cells capable of mesodermal and ectodermal neurogenic differentiation. Human-derived skin precursors are less well characterized. In this study, the isolation and characterization of adherent, mesenchymal stem cell-like cells from human scalp tissue (hSCPs) are described. hSCPs initially isolated by both medium-selection (ms-hSCPs) and single-cell (c-hSCPs) methods were cultured in medium containing epidermal growth factor and fibroblast growth factor-beta. Cultured ms-hSCPs and c-hSCPs demonstrated a consistent growth rate, continuously replicated in cell culture, and displayed a stable phenotype indistinguishable from each other. Both hSCPs expressed surface antigen profile (CDw90, SH2, SH4, CD105, CD166, CD44, CD49d-e, and HLA class I) similar to that of bone marrow mesenchymal stem cells (BM-MSCs). The growth kinetics, surface epitopes, and differentiation potential of c-hSCP cells were characterized and compared with BM-MSCs. In addition to differentiation along the osteogenic, chondrogenic, and adipogenic lineages, hSCPs can effectively differentiate into neuronal precursors evident by neurogenic gene expression of glial fibrillary acid protein, NCAM, neuron filament-M, and microtubule-associated protein 2 transcripts. Therefore, hSCPs may potentially be a better alternative of BM-MSCs for neural repairing, in addition to their other mesenchymal regenerative capacity. Our study suggests that hSCPs may provide an alternative adult stem cell resource that may be useful for regenerative tissue repair and autotransplantations.
EVALUATING APPROACHES RELATING ECOSYSTEM PRODUCTIVITY WITH DESIS SPECTRAL INFORMATION (2022)

Abstract. Data from the DLR Earth Sensing Imaging Spectrometer (DESIS), mounted on the International Space Station (ISS), were used to develop and test algorithms for remotely retrieving ecosystem productivity. Twenty DESIS images were used from three widely separated forested study sites representing deciduous and conifer forests. Gross primary production (GPP) values from eddy covariance flux towers at the sites were matched with DESIS spectral reflectances collected on the same days. Multiple algorithms were successful relating spectral reflectance with GPP, including: spectral vegetation indices (SVI) sensitive to chlorophyll content, SVI used in a photosynthetic light-use efficiency model framework, spectral shape characteristics through spectral derivatives and absorption feature analysis, and statistical models leading to multiband hyperspectral indices from partial least squares regression. Successful algorithms were able to achieve R2 better than 0.7 using a diverse set of observations combining data from different sites from multiple years and at multiple times during the year. The demonstrated robustness of the algorithms provides some confidence in using DESIS imagery to map spatial patterns of GPP.
TheSPoT: Thermal Stress-Aware Power and Temperature Management for Multiprocessor Systems-on-Chip (2017)

Thermal stress including temperature gradients in time and space, as well as thermal cycling, influences lifetime reliability and performance of modern multiprocessor systems-on-chip (MPSoCs). Conventional power and temperature management techniques considering the peak temperature/power consumption do not provide a comprehensive solution to avoid high spatial and temporal thermal variations. This work presents TheSPoT, a novel multilevel thermal stress-aware power and thermal management approach for MPSoCs. At the top level, core consolidation and deconsolidation is performed based on peak temperature, thermal stress, and power consumption constraints. These constraints are also used at the next level, where operating frequencies are determined. At this level, we obtain optimal core frequencies by solving a convex optimization problem. However, thereafter, to reduce the runtime overhead in large MPSoCs, we alternatively propose to use a fast heuristic algorithm. The efficacy of the proposed approaches in reducing the thermal cycles and temporal/spatial temperature gradients is evaluated by comparing the results with the state-of-the-art methods. The evaluation performed on 4-core, 8-core, and 16-core MPSoCs, using PARSEC benchmarks, reveals a considerable reduction in thermal stress. For the 8-core MPSoC case study, on average, for the proposed heuristic(optimal) approach, the mean time to failure improved by 47(35)% compared to the state-of-the-art techniques with only 6(4)% performance degradation. Also, our simulations show that TheSPoT is more efficient in thermal stress reduction when more heterogeneous workloads are used.
Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer (2019)

Epidermal growth factor receptor (EGFR)-targeted therapy in non-small cell lung cancer represents a breakthrough in the field of precision medicine. Previously, we have identified a lead compound, furanopyrimidine <b>2</b>, which contains a (<i>S</i>)-2-phenylglycinol structure as a key fragment to inhibit EGFR. However, compound <b>2</b> showed high clearance and poor oral bioavailability in its pharmacokinetics studies. In this work, we optimized compound <b>2</b> by scaffold hopping and exploiting the potent inhibitory activity of various warhead groups to obtain a clinical candidate, <b>78</b> (DBPR112), which not only displayed a potent inhibitory activity against EGFR<sup>L858R/T790M</sup> double mutations but also exhibited tenfold potency better than the third-generation inhibitor, osimertinib, against EGFR and HER2 exon 20 insertion mutations. Overall, pharmacokinetic improvement through lead-to-candidate optimization yielded fourfold oral AUC better that afatinib along with <i>F</i> = 41.5%, an encouraging safety profile, and significant antitumor efficacy in in vivo xenograft models. DBPR112 is currently undergoing phase 1 clinical trial in Taiwan.
Feedlot Cattle Performance When Fed Silage and Grain From Second-Generation Insect Protected Corn, Parental Line or Reference Hybrids (2011)

Feed conversion and carcass characteristics of cattle fed second generation insect-protected (Bt) corn and corn silage was compared to those fed a nontransgenic parental hybrid and two commercially available nontransgenic reference hybrids. Finishing performance and carcass characteristics were not influenced as a result of corn source.
Ag dissolution kinetics in amorphous GeSe5.5 thin films from “In-situ” resistance measurements versus time (1991)

GeSe5.5 amorphous thin films are evaporated on Ag ribbons deposited on glass substrate. Resistivity measurements of these Ag bands during dissolution are made “in-situ”. The kinetics of the dissolution induced by light emitted by the crucible during evaporation is widely influenced by the temperature of the substrate (77 to 300 K). The dissolution rate varies as the ratio of the initial thicknesses of the GeSe5.5 and Ag layers. A model is proposed which takes into account not only Ag dissolution in depth but also the “extremety effect”. This spectacular effect has not yet received a clear explanation. Sur des bandes d'Ag déposées sur un substrat de verre, on a évaporé des films minces de GeSe5.5. La résistance de ces bandes d'Ag a été mesurée “in-situ” dès la fin de l'évaporation. Le processus de dissolution de l'Ag dû a la lumière émise par le creuset a été étudié en fonction de la température du substrat dans la gamme 77 à 300 K. La vitesse de dissolution varie comme le rapport des épaisseurs de GeSe5.5 et d'Ag. Une modelisation est proposée qui prend en compte non seulement la dissolution de l'Ag en profondeur dans le GeSe5.5 mais aussi “l'effet d'extrémité”. Ce dernier effet très spectaculaire n'a pas encore reçu d'explication claire.
Supplementary Table 1 from Negative Regulation of β<sub>4</sub> Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression (2023)

Supplementary Table 1 from Negative Regulation of β&lt;sub&gt;4&lt;/sub&gt; Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression
Sound Modular Verification of C Code Executing in an Unverified Context (2014)

Over the past decade, great progress has been made in the static modular verification of C code by means of separation logic-based program logics. However, the runtime guarantees offered by such verification are relatively limited when the verified modules are part of a whole program that also contains unverified modules. In particular, a memory safety error in an unverified module can corrupt the runtime state, leading to assertion failures or invalid memory accesses in the verified modules. This paper develops runtime checks to be inserted at the boundary between the verified and the unverified part of a program, to guarantee that no assertion failures or invalid memory accesses can occur at runtime in any verified module. One of the key challenges is enforcing the separation logic frame rule, which we achieve by checking the integrity of the footprint of the verified part of the program on each control flow transition from the unverified to the verified part. This in turn requires the presence of some support for module-private memory at runtime. We formalize our approach and prove soundness. We implement the necessary runtime checks by means of a program transformation that translates C code with separation logic annotations into plain C, and that relies on a protected module architecture for providing module-private memory and restricted module entry points. Benchmarks show the performance impact of this transformation depends on the choice of boundary between the verified and unverified parts of the program, but is below 4% for real-world applications.
Representation of Events in Nerve Nets and Finite Automata (1956)

An elementary exposition of the problems and results obtained during investigations in August, 1951, of the kinds of events any finite automation can respond to by assuming one of certain states.
Stability towards the gastrointestinal simulated digestion and bioactivity of PAYCS and its digestive product PAY with cognitive improving properties (2019)

The peptide derived from Anchovy hydrolysates, Pro-Ala-Tyr-Cys-Ser (PAYCS), was reported to display a neuroprotective effect in vitro in our previous study. The in vivo memory improving effects of PAYCS were investigated in this study. Prior to the scopolamine-induced amnesia mice trial, the stability of PAYCS during digestion was detected and the digestive products were identified. The results showed that PAYCS was susceptible to proteolytic degradation after incubation with pepsin and pancreatin and Pro-Ala-Tyr (PAY) was released and survived during the simulated GI digestion. The results of scopolamine-induced amnesia model trials showed that PAYCS and PAY treatment exhibited cognitive improvement effects in the behavioral tests and different pathways were determined. The results indicated that only PAYCS facilitated cholinergic activity by up-regulating the amount of acetylcholine (Ach) and acetylcholine receptor (AChR). Additionally, both PAYCS and PAY enhanced the superoxide dismutase (SOD) activity. Furthermore, PAYCS was found to be beneficial for the expression of the nuclear factor (erythroid-derived2)-like 2 protein (Nrf2), brain-derived neurotrophic factor (BDNF) and cAMP response element binding protein (CREB). This indicated that PAYCS could regulate the oxidative stress by activating the Nrf2/antioxidant response elements (Nrf2/ARE) pathway. In our study, we demonstrated that the memory improving effects conferred by PAYCS on amnesia mice were linked to the attenuation of the cholinergic system and the activation of Nrf2/ARE and BDNF/CREB signaling.
The RNA Chaperone Hfq Is Important for Growth and Stress Tolerance in Francisella novicida (2011)

The RNA-binding protein Hfq is recognized as an important regulatory factor in a variety of cellular processes, including stress resistance and pathogenesis. Hfq has been shown in several bacteria to interact with small regulatory RNAs and act as a post-transcriptional regulator of mRNA stability and translation. Here we examined the impact of Hfq on growth, stress tolerance, and gene expression in the intracellular pathogen Francisella novicida. We present evidence of Hfq involvement in the ability of F. novicida to tolerate several cellular stresses, including heat-shock and oxidative stresses, and alterations in hfq gene expression under these conditions. Furthermore, expression of numerous genes, including several associated with virulence, is altered in a hfq mutant strain suggesting they are regulated directly or indirectly by Hfq. Strikingly, we observed a delayed entry into stationary phase and increased biofilm formation in the hfq mutant. Together, these data demonstrate a critical role for Hfq in F. novicida growth and survival.
Risk of breast cancer in the UK biobank female cohort and its relationship to anthropometric and reproductive factors (2018)

This study utilizes the UK Biobank study to confirm associations between anthropometric and reproductive factors and the risk of breast cancer development. Result of attributable fraction of risk contributed by each risk factor suggested that lifetime risk of BC can be reduced by controlling weight, reassessing individual approaches to the timing of childbirth and options for contraception and considering early screening for women with family history in the first degree relative.
IFN-γ–Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia (2013)

Cytokines secreted at sites of inflammation impact the onset, progression, and resolution of inflammation. In this article, we investigated potential proresolving mechanisms of IFN-γ in models of inflammatory bowel disease. Guided by initial microarray analysis, in vitro studies revealed that IFN-γ selectively induced the expression of IL-10R1 on intestinal epithelia. Further analysis revealed that IL-10R1 was expressed predominantly on the apical membrane of polarized epithelial cells. Receptor activation functionally induced canonical IL-10 target gene expression in epithelia, concomitant with enhanced barrier restitution. Furthermore, knockdown of IL-10R1 in intestinal epithelial cells results in impaired barrier function in vitro. Colonic tissue isolated from murine colitis revealed that levels of IL-10R1 and suppressor of cytokine signaling 3 were increased in the epithelium and coincided with increased tissue IFN-γ and IL-10 cytokines. In parallel, studies showed that treatment of mice with rIFN-γ was sufficient to drive expression of IL-10R1 in the colonic epithelium. Studies of dextran sodium sulfate colitis in intestinal epithelial-specific IL-10R1-null mice revealed a remarkable increase in disease susceptibility associated with increased intestinal permeability. Together, these results provide novel insight into the crucial and underappreciated role of epithelial IL-10 signaling in the maintenance and restitution of epithelial barrier and of the temporal regulation of these pathways by IFN-γ.
Incidence and risk factors for clinical neurodegenerative Langerhans cell histiocytosis: a longitudinal cohort study (2018)

Neurodegenerative (ND) complications in Langerhans cell histiocytosis (LCH) are a late-onset but dramatic sequelae for which incidence and risk factors are not well defined. Based on a national prospective registry of paediatric LCH patients, we determined the incidence rate of clinical ND LCH (cND-LCH) and analysed risk factors, taking into account disease extent and molecular characteristics. Among 1897 LCH patients, 36 (1·9%) were diagnosed with a cND-LCH. The 10-year cumulative incidence of cND-LCH was 4·1%. cND-LCH typically affected patients previously treated for a multisystem, risk organ-negative LCH, represented in 69·4% of cND-LCH cases. Pituitary gland, skin and base skull/orbit bone lesions were more frequent (P < 0·001) in cND-LCH patients compared to those without cND-LCH (respectively 86·1% vs. 12·2%, 75·0% vs. 34·2%, and 63·9% vs. 28·4%). The 'cND susceptible patients' (n = 671) i.e., children who had experienced LCH disease with pituitary or skull base or orbit bone involvement, had a 10-year cND risk of 7·8% vs. 0% for patients who did not meet these criteria. Finally, BRAF<sup>V</sup><sup>600E</sup> status added important information among these cND susceptible patients, with the 10-year cND risk of 33·1% if a BRAF<sup>V</sup><sup>600E</sup> mutation was present compared to 2·9% if it was absent (P = 0·002).
PNC27 Anticancer Peptide as Targeting Ligand Significantly Improved Antitumor Efficacy of Doxil in HDM2-Expressing Cells (2017)

PNC27 is a promising targeting ligand for Doxil against HDM2-positive cancers.
Budget-Aware Adapters for Multi-Domain Learning (2019)

Multi-Domain Learning (MDL) refers to the problem of learning a set of models derived from a common deep architecture, each one specialized to perform a task in a certain domain (e.g., photos, sketches, paintings). This paper tackles MDL with a particular interest in obtaining domain-specific models with an adjustable budget in terms of the number of network parameters and computational complexity. Our intuition is that, as in real applications the number of domains and tasks can be very large, an effective MDL approach should not only focus on accuracy but also on having as few parameters as possible. To implement this idea we derive specialized deep models for each domain by adapting a pre-trained architecture but, differently from other methods, we propose a novel strategy to automatically adjust the computational complexity of the network. To this aim, we introduce Budget-Aware Adapters that select the most relevant feature channels to better handle data from a novel domain. Some constraints on the number of active switches are imposed in order to obtain a network respecting the desired complexity budget. Experimentally, we show that our approach leads to recognition accuracy competitive with state-of-the-art approaches but with much lighter networks both in terms of storage and computation.
Hyaluronic Acid-Based Drug Conjugates: State-of-the-Art and Perspectives (2013)

Hyaluronan (HA) is biodegradable, highly biocompatible, and contains derivatizable functional groups along its backbone. This relatively simple, non-branched polysaccharide can target specific cell surface receptors making it an attractive polymeric carrier for targeted delivery of therapeutic agents. This article provides an overview of recent developments involving small molecule and bio-macromolecule conjugates of HA as new generation of human therapeutic agents. Several approaches have been developed to prepare conjugates of HA with small molecule drugs, therapeutic peptides, antibodies, and nucleotides. This article discusses such approaches that can modulate the pharmacokinetic and biodistribution of these therapeutic agents so as to appreciate the design criteria for HA based (bio)conjugates or nanoparticles based on their in vitro assay and in vivo pharmacokinetic study.
Rare cause of upper gastrointestinal bleeding in a 27-year-old male patient (2012)

We report the case of a 27-year-old Caucasian man who was transferred to our hospital due to abdominal pain, bloody stools and haematemesis. The patient had no history of abdominal trauma or surgery and was in good general condition. Physical examination was normal and no signs of liver cirrhosis were evident. Laboratory findings showed marked anaemia (haemoglobin 7.3 g/dl) and slightly elevated levels of γ-glutamyltransferase (114 U/l) and alanine transaminase (86 U/l). An oesophago-gastro-duodenoscopy revealed grade IV oesophageal varices with signs of recent bleeding and several cherry red spots (figure 1A, arrows). In addition, fundic varices (figure 1B, arrow) and signs of portal hypertension were present. Endoscopic ligation of oesophageal varices was performed. However, rebleeding occurred and since no signs of underlying liver disease were evident, abdominal …
Laser-fabricated castor oil-capped silver nanoparticles (2011)

Silver nanoparticles were fabricated by ablation of a pure silver plate immersed in castor oil. A Nd:YAG-pulsed Q-switch laser with 1064-nm wavelength and 10-Hz frequency was used to ablate the plate for 10 minutes. The sample was characterized by ultraviolet-visible, atomic absorption, Fourier transform-infrared spectroscopies, and transmission electron microscopy. The results of the fabricated sample showed that the nanoparticles in castor oil were about 5-nm in diameter, well dispersed, and showed stability for a long period of time.
Q&A: Gero Miesenböck (2013)

The unique and important role of the myogenic response in the lymphatic system 32 Physical activity for physiologists 36 The sympathetic nervous system and control of resting blood flow in adults with metabolic syndrome