gebhart/patrepeval huggingface dataset:
Just Genetics and You (2001)

No AccessPerspectives on Communication Disorders and Sciences in Culturally and Linguistically Diverse (CLD) PopulationsArticle1 Apr 2001Just Genetics and You Diane M. Scott Diane M. Scott North Carolina Central UniversityDurham, NC Google Scholar More articles by this author https://doi.org/10.1044/cds7.1.2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References Casselbrant, M. L., Mandel, E. M., Fall, P. A., Rockette, H. E., Kurs-Lasky, M., Bluestone, C. D., & Ferrell, R. E. (1999). The heritability of otitis media: A twin and triplet study.Journal of the American Medical Association, 282(22), 2125–2130. Google Scholar Estivill, X., Govea, N., Barcelo, A., Perello, E., Badenas, C, Romero, E., Moval, L., Scozzari, R., D’Urbano, L., Zeviani, M., & Torroni, A. (1998). Familial progressive sensorineural deafness is mainly due to the mtDNA A1555G mutation and is enhanced by treatment with aminoglyco-sides.American Journal of Human Genetics, 62, 27–35. Google Scholar Fischel-Ghodsian, N., Bykhovskaya, Y., Taylor, K., Kahen, T., Cantor, R., Ehrenman, K., Smith, R., & Keithley, E. (1997). Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations.Hearing Research, 110, 147–154. Google Scholar Gorlin, R. J., Toriello, A. V., & Cohen, M. M. (1995). Hereditary hearing loss and its syndromes. Oxford, England: Oxford University Press. Google Scholar Keats, B. J. B., & Berlin, C. I. (1999). Genomics and hearing impairment.Genome Research: Gene Filters & Pathways, 9(1), 7–16. Google Scholar Keats, B. J. B., Nouri, N., Pelias, M. Z., Deininger, P. L., & Litt, M. (1994). Tightly flanking microsatellite markers for the Usher syndrome type I locus on the short arm of chromosome 11.American Journal of Human Genetics, 54, 681–686. Google Scholar Nagley, P., Zhang, C., Martinus, R. D., Vaillant, F., & Linnane, A. W. (1993). Mitochondrial DNA mutations and human aging: Molecular biology, bioenergetics, and redox therapy.In S. DiMauro & D. C. Wallace (Eds.), Mitochondrial DNA in human pathology (pp. 137–157). New York: Raven Press. Google Scholar Scott, D. M. (1998). Multicultural aspects of hearing disorders and audiology.In D. E. Battle (Ed.), Communication disorders in multicultural populations (pp. 335–354). Boston: Butterworth-Heinemann. Google Scholar Smith, S. D. (1998). The genetics of hearing loss and genetic counseling: What the practicing audiologist needs to know. Presented at the ASHA Telephone Seminar, May 15. Google Scholar Spivey, G. H., & Hirschhorn, N. (1977). A migrant study of adopted Apache children.Johns Hopkins Medical Journal, 140, 43–46. Google Scholar Additional Resources FiguresReferencesRelatedDetails Volume 7Issue 1April 2001Pages: 2-4 Get Permissions Add to your Mendeley library History Published in issue: Apr 1, 2001 Metrics Topicsasha-topicsasha-article-typesasha-sigsCopyright & Permissions© 2001 American Speech-Language-Hearing AssociationLoading ...
Inflow and outflow signatures in flowing wellbore electrical conductivity logs (2002)

Flowing wellbore electrical-conductivity logging provides a means to determine hydrologic properties of fractures, fracture zones, or other permeable layers intersecting a borehole in saturated rock. The method involves analyzing the time-evolution of fluid electrical-conductivity logs obtained while the well is being pumped and yields information on the location, hydraulic transmissivity, and salinity of permeable layers, as well as their initial (or ambient) pressure head. Earlier analysis methods were restricted to the case in which flows from the permeable layers or fractures were directed into the borehole. More recently, a numerical model for simulating flowing-conductivity logging was adapted to permit treatment of both inflow and outflow, including analysis of natural regional flow in the permeable layer. However, determining the fracture properties with the numerical model by optimizing the match to the conductivity logs is a laborious trial-and-error procedure. In this paper, we identify the signatures of various inflow and outflow features in the conductivity logs to expedite this procedure and to provide physical insight for the analysis of these logs. Generally, inflow points are found to produce a distinctive signature on the conductivity logs themselves, enabling the determination of location, inflow rate, and ion concentration in a straightforward manner. Identifying outflow locations and flow rates, on the other hand, can be done with a more complicated integral method. Running a set of several conductivity logs with different pumping rates (e.g., half and double the original pumping rate) provides further information on the nature of the feed points. In addition to enabling the estimation of flow parameters from conductivity logs, an understanding of the conductivity log signatures can aid in the design of follow-up logging activities.
An Optimal Transmit Power Allocation for the Two-Way Relay Channel Using Physical-Layer Network Coding (2009)

A two-way relaying system using the physical-layer network coding (PNC) does not cause the spectral loss induced by the half-duplex signaling. Furthermore, when the total power, which is limited, is properly distributed to transmission nodes in such a system, the system capacity will be enhanced significantly. In this paper, we propose an optimal power allocation in the two- way relay channel employing the PNC protocol. The optimal power allocation is obtained by maximizing the achievable sum- rate of the PNC protocol under a sum-power constraint in a Rayleigh fading channel environment. Numerical experimental results confirm that the proposed power allocation scheme achieves much higher achievable sum-rate performance than the existing schemes.
Production of tumor necrosis factor (TNF) by monocytes from cancer patients and healthy subjects induced by OK-432 in vitro, and its augmentation by human interferon gamma. (1988)

A cytostatic factor was induced in the supernatants of human blood monocytes cultured in vitro with OK-432 at 0.01 KE/ml or more. This cytostatic activity was almost completely abolished by anti-human TNF antibody, and so was thought to be that of TNF. Recombinant human gamma interferon (IFN-gamma) alone did not induce TNF as described in other reports, but enhanced the induction of TNF by OK-432 when added to monocytes before or with OK-432. Monocytes of 20 patients with cancer of the digestive tract and 10 healthy donors were tested for ability to produce cytostatic activity. The frequencies of positive responses to OK-432 and the mean cytostatic activities of the two groups were similar. Moreover both groups included high responders whose monocytes produced potent cytostatic activity with OK-432 alone, and also low responders. Interestingly, marked synergistic effects of IFN-gamma and OK-432 were observed with monocytes that did not produce potent cytostatic activity with OK-432 alone. These results suggested that OK-432 may have a stronger immunomodulatory effect clinically when used in combination with IFN-gamma.
3D Polytope Hulls of E8 4_21, 2_41, and 1_42 (2020)

Using rows 2 through 4 of a unimodular 8X8 rotation matrix, the vertices of E8 4_21, 2_41, and 1_42 are projected to 3D and then gathered & tallied into groups by the norm of their projected locations. The resulting Platonic and Archimedean solid 3D structures are then used to study E8's relationship to other research areas, such as sphere packings in Grassmannian spaces, using E8 Eisenstein Theta Series in recent proofs for optimal 8D and 24D sphere packings, nested lattices, and quantum basis critical parity proofs of the Bell-Kochen-Specker (BKS) theorem.
Aviation weather surveillance systems: advanced radar and surface sensors for flight safety and air traffic management (1999)

The book has 13 chapters. The first chapter is introduction. The second chapter deals with basic background of aviation. The third chapter deals with atmospheric effects on aviation. The fourth chapter deals with origins of harmful atmospheric effects on aircraft. The fifth chapter deals with requirements of systems for aviation weather surveillance. The sixth chapter deals with Doppler weather radar as a primary aviation weather sensor. The seventh chapter deals with modern Doppler weather radars for aviation. The eight chapter deals with other sensors and systems for aviation weather. The ninth chapter deals with integrated system approaches. The tenth chapter deals with automatic detection and tracking of hazardous weather features. The eleventh chapter deals with atmospheric turbulence and its detection by radar. The twelfth chapter deals with lightning and aviation. The thirteenth chapter deals with polarisation diversity radars
Ramificaciones sanitarias de la epidemia de obesidad (2005)

magra [1], y en los seres humanos es resultado de interacciones del medio ambiente con multiples genes. Aunque los humanos estan bien adaptados al ayuno, no lo estan a la nutricion excesiva. De hecho, solo durante los ultimos 100 anos han contado los humanos con un exceso continuo de alimentos. La dieta moderna, rica en grasas y calorias, combinada con la inactividad fisica, ha conducido a una epidemia de obesidad y sobrepeso. La prevalencia de la obesidad ajustada para la edad fue del 30,5% entre 1999 y 2000 [2]. A pesar de la dificultad para estimar con precision el cambio de la prevalencia de obesidad a lo largo del tiempo, debido a las definiciones variables, casi todos los expertos se muestran de acuerdo en que la obesidad esta alcanzando proporciones epidemicas [2-10]. Aunque la obesidad se caracteriza, realmente, por un exceso de tejido adiposo, el indice de masa corporal (IMC), que se expresa como peso corporal (en kilogramos) dividido por la altura (en metros) al cuadrado, proporciona un parametro conveniente para documentar la incidencia de obesidad y establecer guias clinicas. Los individuos con IMC superior a 30 son obesos, mientras que aquellos cuyo IMC se halla entre 25 y 29,9 son diagnosticados de sobrepeso. Existen otras categorias de obesidad basadas en el IMC, entre ellas la «obesidad grave» y las clases I, II y III.
Silicide formation with codeposited titanium-tantalum alloys on silicon (1987)

The formation of disilicides of titanium and tantalum from Ti-Ta alloys codeposited on silicon and polycrystalline silicon have been investigated using x-ray diffraction techniques, resistance measurements, and Auger electron spectroscopy. Titanium and tantalum in the Ti-Ta alloy interacted independently with silicon. There was no titanium/tantalum compound formation and no ternary was detected. The growth of each metal silicide was sustained by continuous out-diffusion of silicon into the Ti-Ta alloy film until the metals were consumed in the silicide transformation. This behavior may account for the absence of phase separation and component accumulation. An initial reaction was observed after the 600 °C, 30 min anneal. The stable end phases formed at temperatures ≥800 °C are TiSi2 and TaSi2. High molecular weight intermetallics such as Ta5Si3 and Ti5Si3 that are normally not detected in Ta-Si and Ti-Si interaction studies were detected, suggesting a stabilizing effect of the impurities. The sheet resistance of the heat-treated samples is: (a) a strong function of the titanium content of the Ti-Ta alloy (low for Ti-rich alloys); (b) lower on silicon substrates; (c) invariant at temperatures &amp;gt;900 °C. The etch rate of the heat-treated samples in buffered hydrofluoric acid increased with increasing titanium content in the film.
Cryo-EM structure of the human MLL1 core complex bound to the nucleosome (2019)

Mixed lineage leukemia (MLL) family histone methyltransferases are enzymes that deposit histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. Despite extensive structural and biochemical studies, the molecular mechanisms whereby the MLL complexes recognize histone H3K4 within nucleosome core particles (NCPs) remain unclear. Here we report the single-particle cryo-electron microscopy (cryo-EM) structure of the NCP-bound human MLL1 core complex. We show that the MLL1 core complex anchors to the NCP via the conserved RbBP5 and ASH2L, which interact extensively with nucleosomal DNA and the surface close to the N-terminal tail of histone H4. Concurrent interactions of RbBP5 and ASH2L with the NCP uniquely align the catalytic MLL1<sup>SET</sup> domain at the nucleosome dyad, thereby facilitating symmetrical access to both H3K4 substrates within the NCP. Our study sheds light on how the MLL1 complex engages chromatin and how chromatin binding promotes MLL1 tri-methylation activity.
A case of papillomatosis arising from the part of D-P flap reconstruction after nine post-operative years. (1991)

A case of papillomatosis arising from the reconstructed skin portion following the D-P flap operation. A 55-year-old Japanese woman, who had developed a tongue cancer.The patient was placed on an irradiation therapy (110 Gy) with a betatron and received functional neck dissection, marginal mandibulectomy, partial resection of tongue and floor of the mouth, and immediate reconstruction using D-P flap operation.There was no local recurrence for nine post-operative years, but the fitness of the denture was loosen recently. A month after the patient had noticed the unfitted denture, the pedunculated tumor mass, lobulated and measured about 3 cm in diameter, arose from the reconstructed skin portion of the floor of the mouth.The mass was resected but recurred three weeks later, so that re-resection and wide elimination of denture were carried out. Histopathological findings were as same as papil-lomatosis arising in the oral mucosa, except that the accessary glands of the skin were scattered in the subcutaneous connective tissue.
Successful long-term antibiotic suppressive therapy in a case of prosthetic valve endocarditis and a case of extensive aortic and subclavian graft infection (2019)

These two cases demonstrate that individualized long-term antibiotic suppressive therapy might be effective in selected patients with complicated PVE unfit or unwilling to undergo high-risk cardiothoracic surgical interventions.
Open-label, phase 2 study of roxadustat for treatment of anemia in patients receiving chemotherapy for non-myeloid malignancies. (2022)

12085 Background: Anemia is prevalent in patients (pts) receiving myelosuppressive chemotherapy (&gt; 60%) and exacerbated by repeated treatment cycles due to cytotoxic agent accumulation. Chemotherapy-induced anemia (CIA) management options are suboptimal. We evaluated the efficacy and safety of roxadustat in pts with anemia receiving myelosuppressive chemotherapy. Methods: This open-label, single-arm, proof-of-concept Phase 2 study included pts with mostly advanced, non-myeloid malignancies and CIA (hemoglobin [Hb] ≤10 g/dL) who had not received red blood cell (RBC) transfusion or erythropoietin-stimulating agents within 4 weeks of enrollment. Patients were treated with oral roxadustat for ≤16 weeks. The primary efficacy endpoint was maximum mean change in Hb within 16 weeks of baseline without RBC transfusion in pts who had received ≥1 dose of roxadustat and who had a baseline and ≥1 post-dose Hb assessment. Hb response and safety data were preliminarily assessed in pts receiving a starting dose of 2.0 mg/kg thrice weekly (TIW) for 4 weeks: doses of 100, 150, and 200 mg were given to pts weighing &lt; 70, 70–100, and &gt; 100 kg, respectively. Following a review of data from these pts, dose was increased to 2.5 mg/kg—150, 200, and 250 mg TIW to pts weighing &lt; 70, 70–100, and &gt; 100 kg, respectively—and adjusted every 4 weeks from Week 5 based on Hb response. Results: Patients were assigned to 2.0 mg/kg (n = 31) and 2.5 mg/kg (n = 61) starting doses, and 89 were assessed for efficacy. The maximum mean Hb change from baseline without RBC transfusion was 2.47±1.51 g/dL and 2.52±1.54 g/dL in the 2.0 mg/kg and 2.5 mg/kg cohorts, respectively. Hb increased by ≥1.5 g/dL in 73% of pts and ≥2.0 g/dL in 61% of pts. Median time to ≥2.0 g/dL Hb increase was 71.0 days. Both cohorts had higher proportions of pts with a Hb increase of ≥1, ≥1.5, or ≥2 g/dL at Week 16 compared with baseline. Median time to ≥1 and ≥2 g/dL Hb increase was shorter in pts who started on 2.5 mg/kg compared with 2.0 mg/kg doses (≥1 g/dL: 30 vs 44; ≥2 g/dL 57 vs 105, respectively). Fewer pts required an RBC transfusion (Week 5 to end of treatment) when starting on 2.5 mg/kg compared with 2.0 mg/kg doses (10.2% vs 20.0%). Subgroup analyses based on major tumor and baseline chemotherapy types demonstrated efficacy of roxadustat at both starting doses. The overall safety profile observed was consistent with the patient population under study. Overall, 92% of pts experienced an adverse event (AE). Most AEs were consistent with the underlying malignancies and chemotherapy regimens used. The incidence of deep vein thrombosis was 15.2% (n = 14) and pulmonary embolism was 9.8% (n = 9). There were 17 deaths (18.5%) during the study; none were attributed to roxadustat, and most were associated with disease progression. Conclusions: Roxadustat increased Hb in CIA regardless of tumor type and chemotherapy regimen. These data support additional clinical study. Clinical trial information: NCT04076943.
Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia (2017)

Multiple sclerosis (MS) is an inflammatory CNS demyelinating disease in which remyelination largely fails. Transmembrane TNF (tmTNF) and TNF receptor 2 are important for remyelination in experimental MS models, but it is unknown whether soluble TNF (solTNF), a major proinflammatory factor, is involved in regeneration processes. Here, we investigated the specific contribution of solTNF to demyelination and remyelination in the cuprizone model. Treatment with XPro1595, a selective inhibitor of solTNF that crosses the intact blood-brain barrier (BBB), in cuprizone-fed mice did not prevent toxin-induced oligodendrocyte loss and demyelination, but it permitted profound early remyelination due to improved phagocytosis of myelin debris by CNS macrophages and prevented disease-associated decline in motor performance. The beneficial effects of XPro1595 were absent in TNF-deficient mice and replicated in tmTNF-knockin mice, showing that tmTNF is sufficient for the maintenance of myelin and neuroprotection. These findings demonstrate that solTNF inhibits remyelination and repair in a cuprizone demyelination model and suggest that local production of solTNF in the CNS might be one reason why remyelination fails in MS. These findings also suggest that disinhibition of remyelination by selective inhibitors of solTNF that cross the BBB might represent a promising approach for treatment in progressive MS.
Determination of hydroacoustic draft tube parameters by high speed visualization during model testing of a Francis turbine (2011)

Francis turbines can experience critical instabilities at high load operating points, limiting their maximum power output. The swirling flow developed in the draft tube produces a cavitating axisymmetric volume, acting as an internal energy source leading to a self-excited surge phenomenon. The pulsation of the vortex rope corresponds to one of the eigenfrequencies of the hydraulic system. Efforts to accurately characterize, simulate and predict this phenomenon have been undertaken by several researchers, using a 1-D hydroacoustic model of the full load vortex rope. The key physical parameters are the mass flow gain factor, standing for the excitation mass source of the hydraulic system, the cavitation compliance factor, representing the wave speed and the thermodynamic damping, modeling the energy dissipation between the liquid and the gas. These parameters need to be determined either numerically or experimentally. The aim of the present investigation is to determine the mass flow gain factor and the cavitation compliance using experimental data obtained during a measurement campaign on a reduced scale Francis turbine model and to compare the results to existing CFD data.
Isolation of biofluids from tissues using a vacuum-assisted filtration biomedical device (2023)

A biopsy is usually used to remove a piece of tissue from a patient for laboratory testing. The interstitial fluid is taken out at the same time as the tissue sample. Since interstitial fluid flows between cells and capillaries in tissues, similar to blood plasma, it is necessary to separate interstitial fluid from tissues in order to study them separately. Vacuum blood sampling has been used to draw blood into vacuum-sealed tubes, while interstitial fluid can be removed directly from the skin using microneedles with standard pumps. However, no methods are available to separate blood or interstitial fluid from the tissue itself for molecular characterization. In this study, we designed a biomedical device that can separate interstitial fluid from tissue using a vacuum-assisted filtration method. The device has a chamber that collects fluid extracted from the tissue that remains on top of the filter. We characterized the weight change and glycan profiles of tissues before and after vacuum-assisted filtration. The results demonstrate that the biomedical device can remove interstitial fluid and facilitate the analysis of tissue-specific molecules while minimizing information from the interstitial fluid.
El Homo videns de un intelectual combativo (Giovanni Sartori) o de cómo emplear el pensamiento para cambiar el mundo (2002)

Si abres el libro de Giovanni Sartori ?Homo videns. La sociedad teledirigida? (1), estate atento a los dos brazos que van a saltar de entre sus paginas para cogerte por los hombros y zarandearte un poco mientras en el aire titilen advertencias de este talante: iVamos, chaval! ?es que no te das cuenta? Espabila un poco, desamodorra tu sensibilidad intelectual, que se esta desquebrajando la fibra que nos permite ahora mismo a ti y a mi conversar a traves de este texto, aunque estemos lejos, aunque alguno de nosotros este muerto.
Population dynamics of mosquito larvae overwintering in southern Japan (1968)

1965年12月から翌年5月まで鹿児島市内の各種水域に棲息する蚊幼虫個体群の動態を, 個体数の変動と令構成の推移の両面から追跡し, 越冬形態について次のような結果を得た.1.ヤマトヤブカ, キンパラナガハシカおよびフタクロホシチビカの3種は, いずれも冬期において若令幼虫が多数出現し, 3月から5月にかけて蛹が現れた(それぞれ第2・第3および第4図).そして翌年の第1代成虫個体群との関連から考えると, 越年した幼虫よりも冬期から早春に孵化する幼虫群の方が量的に重要であると推測される.2.オオクロヤブカは蛹が出現する翌年3月まで終令幼虫だけの個体群であり, 越年した幼虫群がそのまま寒期をすごして翌年の成虫個体群になると思われる(第5図).3.アカイエカは越年した幼虫群に混つて冬期でも蛹が多少残存しており, 羽化する可能性も考えられるが, 全体からみればその割合は少なく, 大多数の幼虫と蛹は早晩死滅すると考えられる(第6図).4.ヒトスジシマカは冬期に幼虫個体群が消滅し, 翌年3月から5月にかけて孵化・蛹化・羽化が確かめられた.従つて, 幼虫態による越冬は行なわれず, 翌年の第1代成虫個体群は早春に孵化する幼虫群に由来するものと推察される(第7図).