gebhart/patrepeval huggingface dataset:
AZD1152 negatively affects the growth of anaplastic thyroid carcinoma cells and enhances the effects of oncolytic virus dl922-947 (2010)

Novel therapeutic approaches are required for the treatment of anaplastic thyroid carcinoma (ATC), an incurable disease resistant to current available therapies. Aurora B is an important mitotic kinase involved in chromosome segregation and cytokinesis. It is overexpressed in many cancers including ATC and represents a potential target for chemotherapy. The effects of AZD1152, a specific Aurora B kinase inhibitor, have been evaluated against ATC, showing G(2)/M accumulation, polyploidy and subsequent cell death by mitotic catastrophe upon drug treatment. Only three administrations of AZD1152 significantly reduced the growth of ATC tumour xenogratfs. Oncolytic viruses in association with other forms of treatment have proven highly promising in preclinical and clinical reports. The oncolytic adenovirus dl922-947 is active against ATC cells, and we have evaluated the effects of the association between AZD1152 and dl922-947. In cells treated with virus and drug, we report additive/synergistic killing effects. Interestingly, the phosphorylation of histone H3 (Ser10), the main Aurora B substrate, is inhibited by dl922-947 in a dose-dependent manner, and completely abolished in association with AZD1152. The combined treatment significantly inhibited the growth of ATC tumour xenografts with respect to single treatments. Our data demonstrate that the Aurora B inhibitor AZD1152, alone or in combination with oncolytic virus dl922-947, could represent a novel therapeutic option for the treatment of ATC.
Palladium(II) Immobilized on Metal–Organic Frameworks for Catalytic Conversion of Carbon Dioxide to Formate (2020)

In this work, we report the design of a two-dimensional (2D) isostructural metal-organic framework containing Pd(II) active sites, using a bipyridyl dicarboxylate linker (Mg(bpdc)(DMF)<sub>2</sub>PdCl<sub>2</sub>]<sub><i>n</i></sub> (Pd@Mg:JMS-2) and [Mn(bpdc)(DMF)<sub>2</sub>PdCl<sub>2</sub>]<sub><i>n</i></sub>(Pd@Mn:JMS-2)). The activated MOFs Pd@Mg:JMS-2a and Pd@Mn:JMS-2a were evaluated as heterogeneous catalysts for the hydrogenation of carbon dioxide (CO<sub>2</sub>) to formate. Under optimal conditions, the MOFs exhibited impressive catalytic activity with formate turnover numbers of 7272 and 9808 for Pd@Mg:JMS-2a and Pd@Mn:JMS-2a, respectively, after 24 h. These catalysts exhibited higher catalytic activity when compared to its homogeneous counterpart that was used as a linker during MOF synthesis. Post-experimental characterization showed that the structural integrity of the MOFs was not altered after catalysis. This work demonstrates that the catalytic activity of homogeneous systems can be enhanced under heterogeneous conditions by anchoring them on MOFs.
Performance evaluation and optimization of random memory access on multicores with high productivity (2010)

The slow progress in memory access latencies in comparison to CPU speeds has resulted in memory accesses dominating code performance. While architectural enhancements have benefited applications with data locality and sequential access, random memory access still remains a cause for concern. Several benchmarks have been proposed to evaluate the random memory access performance on multicore architectures. However, the performance evaluation models used by the existing benchmarks do not fully capture the varying types of random access behaviour arising in practical applications. In this paper, we propose a new model for evaluating the performance of random memory access that better captures the random access behaviour demonstrated by applications in practice. We use our model to evaluate the performance of two popular multicore architectures, the Cell and the GPU. We also suggest novel optimizations on these architectures that significantly boost the performance for random accesses in comparison to conventional architectures. Performance improvements on these architectures typically come at the cost of reduced productivity considering the extra programming effort involved. To address this problem, we propose libraries that incorporate these optimizations and provide innovatively designed programming interfaces that can be used by the applications to achieve good performance without loss of productivity.
To Reopen or Not To Reopen in the Context of Weighted A*. Classifications of Different Trends (Extended Abstract) (2021)

This paper studies the tradeoffs between reopening and not reopening nodes in the context of Weighted A*. A straightforward intuitive scenario is that reopening nodes results in finding shorter solutions than not reopening nodes, at the cost of expanding more nodes. In this paper we classify all possibile tendencies and show an example graph where different tendencies are evident only by varying the W parameter of WA* and without changing the structure of the graph. We then experimentally demonstrate the different tendencies on a number of domains. Finally, we provide experimental support that intelligent reopening polices might lead to better performance. This is a work in progress and we discuss several future directions.
A New Model of Сerebral hemorrhages in newborns rats (2016)

Here we describes a new model of stress-induced cerebral hemorrhage in newborn rats. Using histological and laser speckle imaging, we characterized changes in the brain tissues and circulation associated with the pre- and post-hemorrhage periods.
Chemokines in cancer (2001)

Chemokines are small, chemotactic cytokines that direct migration of leukocytes, activate inflammatory responses and participate in many other pleiotropic functions, including regulation of tumour growth. Chemokines modulate tumour behaviour by three important mechanisms: regulation of tumour-associated angiogenesis, activation of a host tumour-specific immunological response, and direct stimulation of tumour cell proliferation in an autocrine fashion. All of these mechanisms are promising points of cancer intervention, and preclinical mouse models suggest that chemokine antagonists and agonists could become important in the development of new anticancer therapies.
An analysis of fault partitioned parallel test generation (1996)

Generation of test vectors for the VLSI devices used in contemporary digital systems is becoming much more difficult as these devices increase in size and complexity. Automatic Test Pattern Generation (ATPG) techniques are commonly used to generate these tests. Since ATPG is an NP complete problem with complexity exponential to circuit size, the application of parallel processing techniques to accelerate the process of generating test vectors is an active area of research. The simplest approach to parallelization of the test generation process is to simply divide the processing of the fault list across multiple processors, Each individual processor then performs the normal test generation process on its own portion of the fault list, typically without interaction with the other processors. The major drawback of this technique, called fault partitioning, is that the processors perform redundant work generating test vectors for faults covered by vectors generated on another processor. An earlier approach to reducing this redundant work involved transmitting generated test vectors among the processors and fault simulating them on each processor. This paper presents a comparison of the vector broadcasting approach with the simpler and more effective approach of fault broadcasting. In fault broadcasting, fault simulation is performed on the entire fault list on each processor. The resulting list of detected faults is then transmitted to all the other processors. The results show that this technique produces greater speedups and smaller test sets than the test vector broadcasting technique. Analytical models are developed which can be used to determine the cost of the various parts of the parallel ATPG algorithm. These models are validated using data from benchmark circuits.
Packerless Annular Safety Systems: A Viable Alternative To Packer-Based Systems For Offshore Completions (1994)

Abstract The trend in the North Sea has been toward installing annular safety valve (ASV) systems for gas-lifted platform production wells or for tension leg platform (TLP) completions. To satisfy the requirements for a highly reliable annular safety system for the Norske Shell Draugen project and another TLP completion project in the North Sea area, tests were conducted to investigate the feasibility of a polished bore receptacle (PBR)-based ASV system. This paper will compare primary design considerations for packerless and packer-based ASV systems and will focus on the testing and qualification of the PBR nipple assembly to fulfill the requirements for a reliable annular safety system. An overview of completion design options, including packer-based backup systems, is also presented to demonstrate the flexibility of this approach. Testing has determined that a PBR casing nipple assembly can provide a viable alternative to a mechanical ASV packer and its related seals when used to anchor an ASV system. Packer-based systems have also been tested and are in use in North Sea wells. Introduction Demands imposed by industrial, governmental, and regulatory standards concerning personnel and environmental safety on offshore platforms emphasize the need for a fail-safe annular control system.1 These needs can be met by an ASV system, which is designed to effectively contain flow of gas or fluid from the wellbore annulus at a point below the surface, normally at subsurface safety valve installation depth.2,3 When selecting an annular safety system, proper material selection, simplicity of installation and retrieval, the number and nature of the sealing arrangements, dimensional/functional requirements, and economic efficiency are primary considerations for the operator. A review of these requirements leads to close examination of the PBR concept, which has shown its capability to fulfill most of the design/operational requirements.4 The nipple system has the capability to handle high hang-weight and/or thermally-induced loads; and the PBR nipple, pre-installed in the casing string, will permit a variety of completion designs that can be determined later in the well-development cycle. Testing verified that 1) only a minimal pressure drop occurred through the system, and 2) there were no compatibility problems between drilling/cementing operations and the PBR system. Overview-Primary Design Considerations For a Packerless ASV System Simplicity of System Installation and Retrieval Installation of an ASV system in a PBR assembly is accomplished by simply landing the system and lower tubing string in the PBR. An ASV packer requires hydraulic/mechanical activation to effect setting. For simplifying spaceout of the upper tubing string, the PBR system provides a no-go point for hanging off the lower tubing string, which allows accurate measurement of "stretch" in the upper tubing string. This facilitates spaceout for purposes of landing the surface tubing hanger.
Performance results of cooperating expert systems in a distributed real-time monitoring system (1994)

A distributed monitoring and diagnosis system has been developed and successfully applied to real-time monitoring of interplanetary spacecraft at NASA&amp;apos;s Jet Propulsion Laboratory. This system uses a combination of conventional processing and artificial intelligence. Four knowledge-based diagnosis modules are embedded within a monitoring system that detects on-board spacecraft anomalies. Each of the four knowledge-based systems is unique with respect to the others in its implementation or use, resulting in an interesting set of performance results that have been used as guidelines for the design of our next generation real-time diagnostic systems. Details of the distributed architecture, and the general characteristics of the embedded diagnostic are also provided. 1.0 INTRODUCTION There are numerous definitions for real-time systems, the most stringent of which involve guaranteeing correct system response within a domain-dependent or defined period of time. For applic...
Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in T. brucei (2023)

Abstract Cyclic AMP signalling in trypanosomes differs from most eukaryotes due to absence of known cAMP effectors and cAMP independence of PKA. We have previously identified four genes from a genome-wide RNAi screen for resistance to the cAMP phosphodiesterase (PDE) inhibitor NPD-001. The genes were named cAMP Response Protein (CARP) 1 through 4. Here, we report an additional six CARP candidate genes from the original sample, after deep sequencing of the RNA interference target pool retrieved after NPD-001 selection (RIT-seq). The resistance phenotypes were confirmed by targeted RNAi knockdown and highest level of resistance to NPD-001, approximately 17-fold, was seen for knockdown of CARP7 (Tb927.7.4510). CARP1 and CARP11 contain predicted cyclic AMP binding domains and bind cAMP as evidenced by capture and competition on immobilised cAMP. CARP orthologues are strongly enriched in kinetoplastid species, and CARP3 and CARP11 are unique to Trypanosoma . Localization data and/or domain architecture of all CARPs predict association with the T. brucei flagellum. This suggests a crucial role of cAMP in flagellar function, in line with the cell division phenotype caused by high cAMP and the known role of the flagellum for cytokinesis. The CARP collection is a resource for discovery of unusual cAMP pathways and flagellar biology. Importance Trypanosomes are major pathogens of humans and livestock. In addition they have been invaluable as a model system to investigate new biological systems, and not just of protozoa. Equally, they are known to have a lot of unique biology and biochemistry. One example of this is signal transduction by cyclic nucleotides. Some elements, including phosphodiesterases and the catalytic domains of its dozens of adenylate cyclase isoforms, are highly conserved, while the absence of G-proteins, a cAMP-responsive protein kinase A and other known effector types suggests a unique cAMP-dependent pathway, which as yet is mostly uncharacterised. Here, we identify a set of ten Trypanosoma brucei proteins, all localised to its flagellum, that appear to be involved in the production of cAMP, or in mediating its cellular effects. These cAMP Response Proteins (CARPs) were mostly unique to trypanosomes, suggesting a completely novel pathway. Two of the CARPs were shown to bind cAMP and were found to possess structurally conserved cyclic nucleotide binding domains.
Session 9B — Special Session: Doctoral Thesis Award (2006)

The aim of the TTTC Doctoral Thesis Award is to promote and strengthen the interaction between doctoral students who are about to graduate and the industrial community. It also serves as a process that allows their work to be exposed to and tested under real life industrial needs by experts in the field. This is achieved with student presentations in a dedicated VTS session in front of an industrial panel that evaluates, comments and contributes to their work in terms of novelty and advance of industrial practice and this of theoretical methodology. Doctoral students who are expected to graduate in 2006 are invited to submit a one page abstract of their thesis (maximum 700 words). No affiliation is included in this abstract because it undergoes blind review. Since the purpose of this contest is for the student to gain exposure and feedback from the industry, the abstract should clearly address the following three issues: i) problem definition and its relevance to industry, ii) description of existing industrial practices for solving the problem, and iii) a thorough description of the proposed methodology (with a case study, when available) and how it advances theory/practice in the particular field. The abstracts will be reviewed by a panel of industrial and academic specialists for the three issues outlined above. Eight of these abstracts will be selected for the final round that includes a five minute slot for oral presentation and five minute Q&A/feedback slot, during a dedicated session at the IEEE VLSI Test Symposium (VTS'06), Berkeley, CA on April 30-May 4. The winner price includes an honorarium and an invited publication of the presented work in IEEE Design & Test. This event is organized by the TTTC Students Activities Committee.
Effects of Oral Intake of Kimchi-Derived Lactobacillus plantarum K8 Lysates on Skin Moisturizing (2015)

Skin is the soft outer covering of vertebrates that provides protection from pathogenic infection, physical damage, or UV irradiation, and controls body temperature and water content. In this study, we examined the effects of oral intake of kimchi-derived Lactobacillus plantarum K8 lysates on skin moisturizing. In an in vitro study, we observed that the hyaluronic acid content increased in HaCaT cells treated with L. plantarum K8 lysates. Oral administration of L. plantarum K8 lysates effectively attenuated the horny layer formation and decreased epidermal thickening in DNCB-treated SKH-1 hairless mice skin. The damage to barrier function was reduced after 8 weeks of oral administration of L. plantarum K8 lysates as compared with that in the atopic dermatitis mice. For the test with volunteers, we manufactured experimental candy containing 2.1% L. plantarum K8 lysates, while control candy did not contain bacterial lysate. A significant increase in hydration in the experimental candy-administered group as compared with the control candy-administered group was observed on the face after 4 and 8 weeks, and on the forearm after 4 weeks. Decreases in horny layer thickness and TEWL value were observed on the face and forearm of the experimental group. Together, the in vitro cell line and in vivo mouse studies revealed that L. plantarum K8 lysates have a moisturizing effect. A clinical research study with healthy volunteers also showed an improvement in barrier repair and function when volunteers took L. plantarum K8 lysates-containing candy. Thus, our results suggest that L. plantarum K8 lysates may help to improve skin barrier function.
Stereoregular Oligomers of Methyl Methacrylate. V. X-Ray Single Crystal Analysis of Isotactic Pentamer and Syndiotactic Tetramer (1992)

Abstract Stereostructures of the isotactic pentamer (meso-meso-meso-meso isomer) and the syndiotactic tetramer (racemo-racemo-meso isomer) of MMA were determined by x-ray single crystal analysis. The mmmm-pentamer and the rrm-tetramer were isolated by HPLC from the oligomer mixtures prepared with t-C4H9MgBr and with t-C4H9Li/(C2H5)3Al in toluene, respectively. The melting point of the mmmm-pentamer was 59.0–60.0°C, which was lower than that of the rrm-tetramer (99.4–100.2°C). Monoclinic crystals of the mmmm-pentamer and the rrm-tetramer grown from heptane solution belonged to the space groups P21/n and P21, respectively. The conformation of the main chain (t-C4H9-(C‒C)n‒H) of the mmmm-pentamer was ttttttgtg and that of the rrm-tetramer was ttttttg.
Endovascular WEB Flow Disruption in Middle Cerebral Artery Aneurysms (2013)

WEB flow disruption seems to be a promising technique for the treatment of complex MCA aneurysms, particularly those with a wide neck or unfavorable dome-to-neck ratio.
Thiopurine Methyltransferase Genotype Distribution in Irish Patients with Crohn's and Ulcerative Colitis: A Frequency Study (2006)

Aims: The aim of this study was to determine the frequency of TMPT polymorphisms in a population of Crohns and Ulcerative Colitis patients and whether or not this was different to the frequency reported in other Caucasian populations. Source material This was a blinded randomized study. The DNA used in this study was selected from a biobank of specimens used to previously to identify genetic associations with Crohns and Ulcerative Colitis.
Kohn-Sham calculations with self-interaction-corrected local-spin-density exchange-correlation energy functional for atomic systems (1996)

We have investigated the accuracy of the local-spin-density approximation with orbital-density-dependent self-interaction correction (LSDSIC) as proposed by Perdew and Zunger within a Kohn-Sham approach in which electrons with a given spin projection all move in a single optimized effective potential (OEP). We have also studied the accuracy of the Krieger-Li-Iafrate (KLI) approximation to the OEP for the same energy functional in order to assess its applicability to systems in which the integral equation for the OEP cannot be reduced to a one-dimensional problem, e.g., molecules. Self-consistent Kohn-Sham LSDSIC calculations have been performed for atoms with atomic number Z=1--20 in the exchange-only case for the total energy, the highest-occupied orbital energy ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{m}}$, and the expectation value of ${\mathit{r}}^{2}$. In addition, the structure of the resulting exchange potential is examined and compared with the exact exchange-only density-functional theory (OEP method with Hartree-Fock exchange-energy functional) results. Furthermore, we display ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{m}}$, the ionization potential I, and the electron affinity A when both exchange and correlation energy effects are included. Finally, we also consider the results of evaluating the LSDSIC energy functional by employing the exact (in the central-field approximation) single particle orbitals as proposed by Harrison. We find that the LSDSIC energy functional generally leads to calculated values that are superior to those provided by the LSD approximation and that the KLI approximation yields results in excellent agreement with the corresponding exact OEP results for this energy functional. In particular, quantities strongly related to the behavior of the valence electrons are nearly identical in both the OEP and KLI calculations, i.e., the difference between the 〈${\mathit{r}}^{2}$〉 and ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{m}}$ is less than 0.2% on average, while the difference between the calculated I is less than 0.2 millihartree on average with the corresponding difference of only 0.1 millihartree for A. \textcopyright{} 1996 The American Physical Society.
A Temperature-Sensitive Phosphor Used to Measure Surface Temperatures in Aerodynamics (1953)

A thin sheet of a temperature-sensitive phosphor has been used to show the distribution of temperature on the surface of a flat plate in supersonic flow. Calibration of the phosphor is described, and a photograph is shown. Use of a photomultiplier tube permits one to determine the temperature as a function of time, from which recovery temperatures and heat transfer coefficients may be deduced.
Changes in recruitment of the abdominal muscles in people with low back pain: ultrasound measurement of muscle activity. (2004)

This study reinforces evidence for changes in automatic control of TrA in people with LBP. Furthermore, the data establish a new test of recruitment of the abdominal muscles in people with LBP. This test presents a feasible noninvasive test of automatic recruitment of the abdominal muscles.