gebhart/patrepeval huggingface dataset:
Taxol-dependent transcriptional activation of IL-8 expression in a subset of human ovarian cancer. (1996)

Taxol is important in the treatment of both primary and drug-resistant ovarian cancer. Although Taxol is known to stabilize microtubules and block cell mitosis, the effectiveness of this drug exceeds that of other antimitotic agents, suggesting it may have an additional mode of action. Stimulated by murine macrophage studies indicating cytokine induction by Taxol, we have investigated proinflammatory cytokine expression in a series of cell lines and recent explants of human ovarian cancer. Taxol induced secretion of interleukin (IL) 8 but not IL-6, IL-1alpha, or IL-1beta in 4 of 10 samples. Induction was dependent on transcriptional activation, and, in contrast to murine macrophage studies, was apparently independent of an active lipopolysaccharide signaling pathway. Confluent cultures secreted as much IL-8 as proliferating cells. Taxol did not induce IL-8 in breast carcinoma, endometrial stromal, or T-lymphocyte or monocyte cultures. We propose that the local expression of this chemokine in vivo may elicit a host response similar in effectiveness to that of cytokine gene therapy. These data are the first to suggest that a chemotherapeutic agent may have a direct effect on transcription of cytokine and/or growth factor genes in ovarian cancer, and that this effect may not be restricted to proliferating tumor cells.
The Influence of Real-Time Identifiability and Evaluability Performance Feedback on Group Electronic Brainstorming Performance (2005)

This study addresses the question of how to mitigate productivity losses in Electronic Brainstorming (EBS) due to social loafing. This article posits that loafing in the context of EBS may occur due to the combined effect of random group composition and anonymity in conjunction with unregulated individual performance behavior, not anonymity per se, and presents real-time, objective performance feedback as a plausible solution to combat social loafing. An automated real-time performance feedback system was incorporated into an existing EBS system and its effect on performance was empirically examined. Consistent with the suggestions of prior loafing research, in a controlled laboratory experiment groups given the identifiability treatment outperformed other treatments. Similarly, groups given the evaluability treatment outperformed other treatments. Furthermore, groups in the Identifiability and Evaluability treatment showed competitiveness among participants, promoting upward social comparison, and in turn outperforming all other groups in terms of idea quality.
Indicators of survival in patients with portal vein thrombosis (1999)

Janssen, H. L.A.; Wijnhoud, A.; van Hoek, B.; Haagsma, E. B.; Hansen, B. E.; Rosendaal, F. R. Author Information
Probabilistic Mining of Socio-Geographic Routines From Mobile Phone Data (2010)

There is relatively little work on the investigation of large-scale human data in terms of multimodality for human activity discovery. In this paper, we suggest that human interaction data, or human proximity, obtained by mobile phone Bluetooth sensor data, can be integrated with human location data, obtained by mobile cell tower connections, to mine meaningful details about human activities from large and noisy datasets. We propose a model, called bag of multimodal behavior, that integrates the modeling of variations of location over multiple time-scales, and the modeling of interaction types from proximity. Our representation is simple yet robust to characterize real-life human behavior sensed from mobile phones, which are devices capable of capturing large-scale data known to be noisy and incomplete. We use an unsupervised approach, based on probabilistic topic models, to discover latent human activities in terms of the joint interaction and location behaviors of 97 individuals over the course of approximately a 10-month period using data from MIT's Reality Mining project. Some of the human activities discovered with our multimodal data representation include “going out from 7 pm-midnight alone” and “working from 11 am-5 pm with 3-5 other people,” further finding that this activity dominantly occurs on specific days of the week. Our methodology also finds dominant work patterns occurring on other days of the week. We further demonstrate the feasibility of the topic modeling framework for human routine discovery by predicting missing multimodal phone data at specific times of the day.
Relational Integration, Inhibition, and Analogical Reasoning in Older Adults. (2004)

The difficulty of reasoning tasks depends on their relational complexity, which increases with the number of relations that must be considered simultaneously to make an inference, and on the number of irrelevant items that must be inhibited. The authors examined the ability of younger and older adults to integrate multiple relations and inhibit irrelevant stimuli. Young adults performed well at all but the highest level of relational complexity, whereas older adults performed poorly even at a medium level of relational complexity, especially when irrelevant information was presented. Simulations based on a neurocomputational model of analogical reasoning, Learning and Inference with Schemas and Analogies (LISA), suggest that the observed decline in reasoning performance may be explained by a decline in attention and inhibitory functions in older adults.
(+)-N-2'-Noradiantifoline: A New Aporphine-Benzylisoquinoline Alkaloid (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(+)-N-2'-Noradiantifoline: A New Aporphine-Benzylisoquinoline AlkaloidHélène Guinaudeau, Maurice Shamma, and Kemal Hüsnü Can BaserCite this: J. Nat. Prod. 1982, 45, 4, 505–506Publication Date (Print):July 1, 1982Publication History Published online1 July 2004Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/np50022a029https://doi.org/10.1021/np50022a029research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cyber-security considerations for the smart grid (2010)

The electrical power grid is evolving into the “smart grid.” The goal of the smart grid is to improve efficiency and availability of power by adding more monitoring and control capabilities. These new technologies and mechanisms are certain to introduce vulnerabilities into the power grid. In this paper we provide an overview of the cyber security state of the electrical power grid. We highlight some of the vulnerabilities that already exist in the power grid including limited capacity systems, implicit trust and the lack of authentication. We also address challenges of complexity, scale, added capabilities and the move to multipurpose hardware and software as the power grid is upgraded. These changes create vulnerabilities that did not exist before and bring increased risks. We conclude the paper by showing that there are a number mitigation strategies that can help keep the risk at an acceptable level.
Discriminative training for improving letter-to-sound conversion performance (2008)

In this paper, we propose to use discriminative training (DT) for improving letter-to-sound (LTS) conversion performance. LTS is a critical component in both ASR and TTS for predicting the correct pronunciation of a word not included in the lexicon. For TTS applications, predicting the proper pronunciation of an out-of-vocabulary person/place name, especially a name with foreign origin can be challenging. We utilize discriminative training, which has been successfully used in speech recognition, to sharpen the baseline N-grams of grapheme-phoneme pairs. We address the problem in a unified framework of discriminative training. Two criteria, maximum mutual information (MMI) and minimum phoneme error (MPE), are investigated. Experimental results show that DT yields a small (3.8-4.6% relative) but consistent error reduction across all databases tested. In addition, we observe that by pinpointing the local errors in a finer resolution, we can obtain a better discriminative model.
Experimental Demonstration of the Stability of Berry’s Phase for a Spin-1/2Particle (2009)

The geometric phase has been proposed as a candidate for noise resilient coherent manipulation of fragile quantum systems. Since it is determined only by the path of the quantum state, the presence of noise fluctuations affects the geometric phase in a different way than the dynamical phase. We have experimentally tested the robustness of Berry's geometric phase for spin-1/2 particles in a cyclically varying magnetic field. Using trapped polarized ultracold neutrons, it is demonstrated that the geometric phase contributions to dephasing due to adiabatic field fluctuations vanish for long evolution times.
Grating Couplers for Coupling between Optical Fibers and Nanophotonic Waveguides (2006)

Nanophotonic waveguides and components are promising for use in the large-scale integration of photonic circuits.Coupling light between nanophotonic waveguides and a single-mode fiber is an important problem and many different solutions have been proposed and demonstrated in recent years.In this paper, we discuss a grating coupler approach.Grating couplers can be placed anywhere on a circuit and can easily be integrated.We have experimentally demonstrated >30% coupling efficiency with a 1 dB bandwidth of 40 nm on standard wafers.Theoretically, the coupling efficiency can be improved to >90% using an optimized grating design and layer stack.The fabrication of the couplers in silicon-on-insulator and in indium phosphide membranes is also discussed.
Transport of rate‐limited sorbing solutes in heterogeneous porous media: Application of a one‐dimensional multifactor nonideality model to field data (1992)

The results of several experiments reported in the literature indicate that the assumptions of porous media homogeneity and instantaneous sorption are generally invalid for transport of sorbing solute at the field scale. In addition, it is probable that the “nonideal” transport observed is caused by more than one factor. The purpose of this work was to evaluate the ability of a one‐dimensional, multifactor nonideality model to represent the nonideal transport of sorbing solutes at the field scale. For this model the two‐domain approach is used to represent heterogeneity, and sorption is represented as being essentially instantaneous for a portion of the sorbent and rate limited for the remainder. Data (breakthrough curves) obtained from four field experiments reported in the literature were used to test the performance of the model. With one exception, data from laboratory or field experiments were used to identify values for input parameters; the exception concerned an assumption of a uniform distribution of sorbent between the advective and nonadvective pore water domains. Specification of input parameters independent of the data being simulated allowed the model to be used in a predictive mode. On the basis of the good match between predictions produced with the model and the data, it appears that the model provides a valid representation of sorption dynamics and solute transport for field‐scale systems influenced by heterogeneity and rate‐limited sorption. The model should be useful in situations where the extensive input data required for more complex models (e.g., stochastic) are not available.
Induction of Cytokines and Chemokines by Toll-like Receptor Signaling: Strategies for Control of Infammation (2010)

Recognition of the pathogen-associated molecular pattern (PAMP) by host Toll-like receptors (TLR) is an important component of the innate immune response for countering against invading viruses, bacteria, and fungi. Upon PAMP recognition, the TLR induces intracellular signaling cascades that involve adapter, signalosome, and transcription factor complexes and result in the production of both pro- and anti-inflammatory cytokines and chemokines. An inflammatory response for a short duration can be beneficial because it helps to clear the infectious agent. However, prolonged inflammation can be detrimental because it may cause host toxicity and tissue damage. Indeed, excessive production of inflammatory cytokines and chemokines via TLR pathways is often associated with many inflammatory and autoimmune diseases. Therefore, fine control of inflammation in the TLR pathway is highly desirable for effective host defense. In this article, we review intrinsic control mechanisms that include a balance between pro-inflammatory and anti-inflammatory cytokines and chemokines, production of host effectors, and regulation at the level of adapter, signalosome, and transcription factor complexes in the TLR pathways. We also discuss how understanding of the TLR signaling steps leads to the development of small-molecule drugs that can interfere with the formation of active adapter, signalosome, and adapter complexes.
Iliac arteriovenous fistula -endovascular stent-graft treatment followed by aneurysm sac embolization due to persistent endoleak type 2 (2021)

The presented case is a 66-year old, previously healthy male patient with a 60 mm iliac artery aneurysm and arteriovenous fistula ( AVF) between the left common iliac artery and vein. The patient was treated successfully endovascular with a stent graft followed by embolization of the persistent endoleak type 2. The patient experienced sudden left-sided lower abdominal pain and left leg swelling with a 3-day onset. Upon admission, the patient displayed normal vital signs. There was no limb ischemia and echocardiography was within the normal limit. The abdomen was soft and without pain on examination or pulsatile mass. The bifurcated EVAR stent graft was deployed infrarenal. The left internal iliac artery was embolized with micro coils. There was an immediate effect on the left limb, with dramatically decreased swelling. CT showed persistent fistulation to the common iliac vein and type 2 endoleak on a three-month follow-up control. The left femoral vein was approached, and aneurysm sac embolization was performed with detachable micro coils. Three months follow-up CT control demonstrated shrinkage of the aneurysm sac with a maximal diameter of 46 mm and no flow through the AVF.
Routine Use of Nasogastric Tubes After Radical Cystectomy (2011)

No AccessJournal of UrologyOpposing View1 May 2011Routine Use of Nasogastric Tubes After Radical Cystectomy Benjamin M. Whittam, Michael S. Cookson, and Randall G. Rowland Benjamin M. WhittamBenjamin M. Whittam More articles by this author , Michael S. CooksonMichael S. Cookson More articles by this author , and Randall G. RowlandRandall G. Rowland More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.026AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail References 1 : Bench-to-bedside review: routine postoperative use of the nasogastric tube — utility or futility?. Critical Care2007; 11: 201. Google Scholar 2 : Prophylactic nasogastric decompression after abdominal surgery. Cochrane Database Syst Rev2007; . issue 3, article No. CD004929. Google Scholar 3 : Fast track program in patients undergoing radical cystectomy: results in 362 consecutive patients. J Am Coll Surg2010; 210: 93. Google Scholar 4 : Routine nasogastric tubes are not required following cystectomy with urinary diversion: a comparative analysis of 430 patients. J Urol2003; 170: 1888. Link, Google Scholar 5 : Analysis of early complications after radical cystectomy: results of a collaborative care pathway. J Urol2002; 167: 2012. Link, Google Scholar 6 : Is nasogastric intubation necessary on colon operations?. Am J Surg1987; 154: 640. Google Scholar 7 : Early nasogastric tube removal combined with metoclopramide after radical cystectomy and urinary diversion. J Urol1999; 162: 1599. Link, Google Scholar Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TennesseeDivision of Urology, University of Kentucky, Lexington, Kentucky© 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 5May 2011Page: 1568-1570 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Benjamin M. Whittam More articles by this author Michael S. Cookson More articles by this author Randall G. Rowland More articles by this author Expand All Advertisement PDF downloadLoading ...
Shoot-tip grafting in vitro : impact in the citrus industry and research applications. (2007)

This chapter discusses in detail the different steps of citrus shoot-tip grafting in vitro, and the elimination of pathogens and its research and industrial applications are reviewed.
A workspace‐orientated needle‐guiding robot for 3T MRI‐guided transperineal prostate intervention: evaluation of in‐bore workspace and MRI compatibility (2012)

The new workspace evaluation method quantifies the workspace utilization of the in-bore-operated robots for MRI-guided transperineal prostate interventions, providing a useful tool for evaluation and new robot design. The robot creates insignificant electromagnetic noise during typical prostate imaging sequences.
Improved Algorithms for Topic Distillation in a Hyperlinked Environment (2017)

column Share on Improved Algorithms for Topic Distillation in a Hyperlinked Environment Authors: Krishna Bharat Digital Equipment Corporation System Research Center, Palo Alto, CA Digital Equipment Corporation System Research Center, Palo Alto, CAView Profile , Monika R. Henzinger Digital Equipment Corporation System Research Center, Palo Alto, CA Digital Equipment Corporation System Research Center, Palo Alto, CAView Profile Authors Info & Claims ACM SIGIR ForumVolume 51Issue 2July 2017 pp 194–201https://doi.org/10.1145/3130348.3130367Published:02 August 2017Publication History 3citation56DownloadsMetricsTotal Citations3Total Downloads56Last 12 Months2Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A novel robust harmonic injection method for single-switch three-phase discontinuous-conduction-mode boost rectifiers (1998)

This paper describes a new robust low-cost harmonic-injection method for single-switch three-phase discontinuous-conduction-mode (DCM) boost rectifiers. In the proposed method, a periodic voltage is injected in the control circuit to vary the duty cycle of the rectifier switch within a line cycle so that the fifth-order harmonic of the input current is reduced to meet the IEC555-2 requirement. Since the injected voltage signal, which is proportional to the inverted AC component of the rectified three-phase line-to-line input voltages, is employed, the injected duty-cycle variations are naturally synchronized with the three-phase line-to-neutral input voltages. In addition, the injected harmonic signal naturally contains desirable higher order harmonics, such as sixth, twelfth, eighteenth, etc., which are more effective in improving total harmonic distortions (THDs) than harmonic-injection methods based on the sixth-order harmonic only.
A Comprehensive Discovery Platform for Organophosphorus Ligands for Catalysis (2021)

The design of molecular catalysts typically involves reconciling multiple conflicting property requirements, largely relying on human intuition and local structural searches. However, the vast number of potential catalysts requires pruning of the candidate space by efficient property prediction with quantitative structure-property relationships. Data-driven workflows embedded in a library of potential catalysts can be used to build predictive models for catalyst performance and serve as a blueprint for novel catalyst designs. Herein we introduce &lt;i&gt;kraken&lt;/i&gt;, a discovery platform covering monodentate organophosphorus(III) ligands providing comprehensive physicochemical descriptors based on representative conformer ensembles. Using quantum-mechanical methods, we calculated descriptors for 1,558 ligands, including commercially available examples, and trained machine learning models to predict properties of over 300,000 new ligands. We demonstrate the application of &lt;i&gt;kraken&lt;/i&gt; to systematically explore the property space of organophosphorus ligands and how existing datasets in catalysis can be used to accelerate ligand selection during reaction optimization.
High frequency of concomitant mastocytosis in patients with acute myeloid leukemia exhibiting the transforming KIT mutation D816V (2010)

The KIT mutation D816V is associated with autonomous growth of mast cells (MC) and is detectable in most patients with systemic mastocytosis (SM), including cases with associated hematologic non-MC-lineage disease (AHNMD). Recently, KIT D816V was reported to be expressed in patients with acute myeloid leukemia (AML). However, it was not clarified whether these patients have co-existing occult SM. We investigated neoplastic cells in 101 patients with AML for expression of KIT D816V. In 7/101 patients (6.9%), KIT D816V was detectable. After a thorough histologic, molecular, and biochemical analysis, all 7 cases were found to have an associated SM, leading to the final diagnosis SM-AML. Microdissected tryptase+ MC displayed KIT D816V in all patients tested, whereas CD34+ blasts exhibited KIT D816V in only 2/4 patients. In one AML patient, SM without KIT D816V was detected. In all other patients, no associated SM was found, and leukemic blasts were negative for KIT D816V. In summary, our data show that KIT D816V in AML is highly associated with co-existing SM (SM-AML). Moreover, our data show that AML blasts may lack this transforming target-mutant, which may be important when considering the use of KIT D816V-targeting drugs for treatment of patients with KIT D816V-positive AML.
Waste Management between Thermal Treatment and Recycling (2012)

Abstract Die Abfallwirtschaft in Deutschland behandelt eine Menge von 359 Mio. Tonnen. Den größten Anteil haben Bau‐ und Abbruchabfälle mit 54 %. Die Behandlungsverfahren dafür unterscheiden sich stark von denen für Siedlungsabfälle. Gemäß Europäischer Abfallrichtlinie ist Recycling gegenüber einer energetischen Verwertung in der Hierarchie der Abfallbehandlungsverfahren höher bewertet. Bei der thermischen Behandlung entscheidet die Energieeffizienz des Verfahrens, ob eine Behandlung als Verwertung oder Beseitigung gilt. Nach dieser Richtlinie erfolgt die Berechnung der Energieeffizienz stark vereinfacht mit der sogenannten R1‐Formel. Veröffentlichte Daten zu Wärme‐ und Stromproduktion verschiedener thermischer Abfallbehandlungsanlagen werden mit der R1‐Formel und Daten aus der Literatur verglichen. Mengen und Entsorgungswege sowie Möglichkeiten zur Bewertung von Abfallbehandlungsverfahren werden diskutiert.