gebhart/patrepeval huggingface dataset:
Higher burden of asthma symptoms and increased blood eosinophils in ACOS (2016)

<b>Background:</b> Asthma with fixed airflow obstruction (FAO) is associated to more symptoms. Asthma-COPD overlap syndrome (ACOS) has been recognized as a new phenotype, but few studies are available. <b>Aims and objectives:</b> To evaluate the differences between asthmatic subjects with or without FAO and ACOS regarding asthma events and inflammation. <b>Method:</b> We included 755 subjects in the age group 20-79 years from three National Health and Nutrition Examination Surveys (2007-12) with physician-diagnosed asthma. 220 subjects had FAO, defined as FEV<sub>1</sub>/FVC &lt;LLN after bronchodilation. Three groups were created: asthma without FAO (reference group), asthma with FAO (FAO group) and asthma with FAO and chronic bronchitis, emphysema or ≥10 pack years (ACOS group). Frequent symptoms (≥2 symptoms the previous year), asthma attacks the previous year, exhaled NO (FeNO; elevated ≥25 ppb) and blood eosinophils (B-Eos; elevated ≥300 cells/µl) were studied. <b>Results:</b> The FAO and ACOS groups reported more symptoms than the reference group, while no difference was seen for attacks. The ACOS group had higher B-Eos counts but lower FeNO than the reference group. The association between more symptoms and FAO and ACOS, respectively, remained significant in the adjusted analyses (aOR (95%CI)): 2.2 (1.3-3.5) for FAO and 1.9 (1.1-3.3) for ACOS; as well as the relation between higher B-Eos count and ACOS: 2.0 (1.2-3.5). There was no association with FeNO. <b>Conclusion:</b> Asthma with fixed airflow obstruction and ACOS were associated to more symptoms than asthma without these characteristics (reference group). No relation to elevated biomarkers was seen for the FAO group while ACOS related to higher B-Eos counts when compared to the reference group.
Unsupervised feature learning for audio classification using convolutional deep belief networks (2009)

In recent years, deep learning approaches have gained significant interest as a way of building hierarchical representations from unlabeled data. However, to our knowledge, these deep learning approaches have not been extensively studied for auditory data. In this paper, we apply convolutional deep belief networks to audio data and empirically evaluate them on various audio classification tasks. In the case of speech data, we show that the learned features correspond to phones/phonemes. In addition, our feature representations learned from unlabeled audio data show very good performance for multiple audio classification tasks. We hope that this paper will inspire more research on deep learning approaches applied to a wide range of audio recognition tasks.
The effect of bioreducible cytotoxic drugs upon the SOS response of Escherichia coli (1991)

The DNA damaging activity of RSU 1069 and seven of its&#13;\nanalogues (RSU 1131, RSU 1164, RSU 1150, RB 7040, RSU 1172, RSU 1137 and RSU 1170) plus misonidazole and CB 1954 were investigated using the SOS-Chromotest&#13;\nThe SOS-Chromotest is a genotoxicity assay that monitors the&#13;\ninduction of the SOS response, which is induced in response to DNA damage. The strains used were PQ37, which possesses a uvrA mutation and is deficient in UvrA excinuclease activity, and PQ35, which is uvr and UvrABC excinuclease conpetent. These strains were exposed to the compounds being investigated under both oxic and hypoxic conditions.&#13;\nThe results showed that RSU 1069 and some of its analogues&#13;\nwere more active than misonidazole under both oxic and hypoxic conditions. This increase was due to their aziridine side-chains.&#13;\nWith the exception of RSU 1137 and RSU 1170 all of the compounds showed altered SOS induction activities between oxic and hypoxic conditions. This alteration was shown to correlate with increased reduction of their nitro-groups under hypoxia. There was a difference in the hypoxic activities of RSU 1(J69 and some of its analogues between the uvrA-strain and the uvr -strain. With the uvrA-strain RSU 1069 showed decrease activity under hypoxia compared to oxia, whereas, the converse applied with the uvr -strain. This was interpreted to mean that RSU 1069 caused some&#13;\ndamage that required an active UvrABC excinuclease to produce an SOS response. It has been proposed that this damage takes the form of DNA crosslinks. RSU 1137 showed insignificant SOS induction and this was demonstrated to be due to its nitro-group not being reduced. It was suggested that the ring opened aziridine side chain of RSU 1137 in some way inhibited its bioreduction. The order of&#13;\nactivity of the drugs for SOS induction activities did not&#13;\ncorrelate with that for their toxicities. This indicated that DNA lesions other than, or in addition to, those responsible for cytotoxicity induced the SOS response.&#13;\nThe DNA damaging activity and mutagenicity of RSU 1069 was&#13;\nalso investigated using Ml3 phage rfDNA. Radiation reduced RSU 1069 was shown to produce some relatively long lived product that was more active towards DNA than unreduced RSU 1069, as judged by phage survival. Unreduced RSU 1069 was shown to be non-mutagenic, producing mutation rates under 1.5 times background level.&#13;\nThe effect of strict hypoxic conditions upon the SOS response was investigated using the SOS-Chromotest with the uvrA tester strain. The results showed that the SOS response was induced under strictly anaerobic conditions in E. coli but that the response was altered compared to that obtained aerobically. The nature of the alteration was not determined as six different compounds, with five different modes of action, were used as SOS-inducers and all showed&#13;\ndifferent types of response under hypoxic conditions.
Three-Dimensional Dual-Polarized Frequency Selective Structure With Wide Out-of-Band Rejection (2013)

A new three-dimensional bandpass frequency-selective structure (FSS) is proposed for dual-polarized applications. Each square unit cell of the proposed FSS consists of vertical and horizontal double-sided parallel-strip lines (DSPSLs) and a thin metallic plate. Furthermore, the parallel-strip lines of every DSPSL are connected together through via holes. Using this arrangement, multimode resonators are established in the proposed structure. At lower frequencies, the substrate mode propagates and two resonators along the DSPSL are constructed, leading to a bandpass response with two transmission poles. At higher frequencies, the air mode is reflected by two resonates along the inserted plate, resulting in a stopband with two transmission zeros. The operating principle for this FSS is explained with the aid of an equivalent circuit model. Moreover, a parametric study of the proposed FSS is also carried out and design guidelines are formulated. As an example, a prototype of the proposed FSS is designed, fabricated, and tested. Measured results demonstrate that the FSS exhibits dual polarizations, high out-of-band rejection, and stable frequency response under both transverse electric (TE) and transverse magnetic (TM) polarizations of an obliquely incident wave.
Change or Paradigm Shift in the Swedish Preschool (2010)

Artikeln diskuterar olika förskolereformer i Sverie och ställer fråpgan om den svenska modellen, EDUCARE, är hotad av ideer om skolförberedelse och senare anställningsbarhet.Förändringarna studeras på olika nivåer och från ett historiskt perpspektiv. Slutsatsen är att reformarbetena måste förstås dels i förhållande till nationella ideer, föreställninar och traditioner, dels i förhållande till internationella organisationer. Vidare forskrning som uppmärksammar vad som faktiskt sker i den lokala kontexten rekommenderas.
Supplementary Figure 2 from Intravesical Immunotherapy of Superficial Bladder Cancer with Chitosan/Interleukin-12 (2023)

Supplementary Figure 2 from Intravesical Immunotherapy of Superficial Bladder Cancer with Chitosan/Interleukin-12
An efficient method for the extraction of DNA from formalin-fixed, paraffin-embedded tissue by sonication. (1991)

A method was developed for fast and efficient isolation of DNA from formalin-fixed, paraffin-embedded tissue sections for subsequent use in PCRs and DNA hybridization assays. The method relies on the use of a sonicating water bath to disrupt tissue samples to which a small amount of micro-sized glass beads have been added. The sonicating glass beads provide fast and efficient physical shearing of fixed tissue sections, allowing for quick release and solubilization of the DNA. The extraction process from paraffin section to amplifiable target DNA takes 30 minutes. The method eliminates the need for repetitive solvent extractions and exhaustive proteinase K digestion. PCR amplification of human genomic and viral target sequences was successfully carried out on DNA isolated from a number of different types of normal and infected tissues.
Molecular Cancer Imaging in the Second Near‐Infrared Window Using a Renal‐Excreted NIR‐II Fluorophore‐Peptide Probe (2018)

In vivo molecular imaging of tumors targeting a specific cancer cell marker is a promising strategy for cancer diagnosis and imaging guided surgery and therapy. While targeted imaging often relies on antibody-modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) shows promise in reaching sub-centimeter depth with microscale resolution. Here, a novel peptide (named CP) conjugated NIR-II fluorescent probe is reported for molecular tumor imaging targeting a tumor stem cell biomarker CD133. The click chemistry derived peptide-dye (CP-IRT dye) probe afforded efficient in vivo tumor targeting in mice with a high tumor-to-normal tissue signal ratio (T/NT > 8). Importantly, the CP-IRT probes are rapidly renal excreted (≈87% excretion within 6 h), in stark contrast to accumulation in the liver for typical antibody-dye probes. Further, with NIR-II emitting CP-IRT probes, urethra of mice can be imaged fluorescently for the first time noninvasively through intact tissue. The NIR-II fluorescent, CD133 targeting imaging probes are potentially useful for human use in the clinic for cancer diagnosis and therapy.
[Symptomatic Black Queen Cell Virus infection of drone brood in Hessian apiaries]. (2003)

The Black Queen Cell Virus (BQCV) can affect brood of the honey bee (Apis mellifera). In general queen cells are endangered showing dark coloured cell walls as typical symptoms. Worker- and dronebrood can be infected by BQCV but normally without clinical symptoms. This paper describes for the first time a symptomatic BQCV-infection of diseased drone brood found on two bee yards in Hessen/Germany in 2001. The drone larvae were seriously damaged and some of them were dead. Samples of the affected brood were tested for BQCV by the PCR detection method. A BQCV specific nucleic acid fragment was found. The PCR product were sequenced and aligned with the relevant GenBank entry. At the nucleic acid level as well as at the deduced protein level the isolate showed a high similarity with the south african isolate noted in GenBank.
An in vitro model for human endothelial cell seeding of a small diameter vascular graft. (1989)

A precise system was devised to measure the kinetics of attachment of human venous endothelium to a variety of materials and substrates. Cells were labelled in a postconfluent state with tritiated thymidine, harvested, and a cell suspension seeded into a 4 mm PTFE graft. After a 90 minute incubation period, one half of the graft segment was sacrificed and the remaining portion placed in a perfusion system (225 cc/min) for 1 hour. Graft segments, effluents, and seeding suspension were assayed in a beta scintillation counter. The percentage of cells that attached pre- and postperfusion were determined, as well as the retrieval of tritium from the system. Initially, 71% of seeded cells attached to grafts coated with fibronectin, with significantly less (60%) remaining attached after perfusion. Only 10% of cells initially attached to uncoated grafts, with 4% retained postperfusion. Retrieval of tritium averaged 102 +/- 10% for all experiments. This system determines both pre- and postperfusion attachment of human endothelial cells to vascular grafts following manipulation of numerous variables, including graft material, substrate, incubation time, and seeding density. An optimal seeding protocol for human trials can thus be determined.
Combining physical therapy and cognitive behavioral therapy techniques to improve balance confidence and community participation in people with unilateral transtibial amputation who use lower limb prostheses: a study protocol for a randomized sham-control clinical trial (2019)

ClinicalTrials.gov, NCT03411148. Registration date: January 26, 2018.
Optical properties of shallow In/sub 1-x/Ga/sub x/As/In/sub 1-y/Ga/sub y/As superlattices for optoelectronic applications (2002)

The authors present detailed photoluminescence, photovoltage, and femtosecond time-resolved luminescence upconversion studies on thin superlattices of type In/sub 1-x/Ga/sub x/As/In/sub 0.53/Ga/sub 0.47/ The sample quality, as derived from sputtered neutrals mass spectrometry data and from the spectral linewidths and excitonic enhancement observed in optical spectra is comparable to very high quality In/sub 0.53/Ga/sub 0.47/As/InP multiple quantum wells. Spectroscopic results agree well with calculations of the materials band structure predicting a mixed type-I/type-II superlattice band structure. Ultrafast carrier capture of charge carriers into the superlattice states has been demonstrated. The high excitonic enhancement and the low confinement energies of holes in this material system make it well suited for fast electrooptic devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Aerobic Degradation of Recalcitrant Organic Compounds by Microorganisms (2004)

This chapter contains sections titled: Introduction: Characteristics of Aerobic Microorganisms Capable of Degrading Organic Pollutants Principles of Bacterial Degradation Typical Aerobic Degrading Bacteria Growth-associated Degradation of Aliphatics Diversity of Aromatic Compounds: Unity of Catabolic Processes Extension of Degradative Capacities Cometabolic Degradation of Organopollutants Overcoming Persistent Pollutants by Cooperation Between Anaerobic and Aerobic Bacteria Degradative Capacities of Fungi Metabolism of Organopollutants by Microfungi Aliphatic Hydrocarbons Aromatic Compounds Degradative Capabilities of Basidiomycetous Fungi The Ligninolytic Enzyme System Degradation of Organopollutants Conclusions References
[Inhibition of monoamineoxidase and day-night-rhythm: correlation of physiological and biochemical parameters (author's transl)]. (1976)

The motor activity of rats following medication with monoamine-oxidase inhibitors was registered continuously over a period of nine days. At the same time the enzyme activity of monoamineoxidase (MAO) form A and B and the concentration of serotonin, tryptophan, 5-hydroxyindolacetic acid and norepinephrine were measured in brain stem and hippocampi. We draw the following conclusions: 1. The rhythmic changes in the levels of serotonin and norepinephrine play a minor role in the circadian rhythm. 2. MAO-inhibitors influence the timing mechanism. A relationship between this finding and the therapeutic effect on depressed patients is discussed. 3 Dopaminergic neurons antagonize the activation by adrenergic neurons during the dark-period.
I n s i t u patterning of GaAs by focused ion beam (1991)

We have investigated the characteristics of ion beam induced spontaneous etching (IBISE) of GaAs by 15 keV Ga focused ion beam (FIB) irradiation and Cl2 gas. The area irradiated by the FIB showed high spontaneous etch rate to the exposure to Cl2 ambient. It was observed that the spontaneous etching depends on the residual H2O partial pressure. At H2O partial pressure less than 6×10−7 Torr, the threshold dose to observe IBISE was about 1015 ions/cm2 at a substrate temperature of 100 °C. However, at H2O partial pressure of 3×10−6 Torr, the threshold dose decreased below 1014 ions/cm2 at a substrate temperature of 90 °C. The small amount of H2O in Cl2 gas effectively decreases the threshold dose resulting in a reduction of radiation damage of the substrate and increasing the processing rate.
Discrimination of cylinders with different wall thicknesses using neural networks and simulated dolphin sonar signals (2003)

This paper describes a method integrating neural networks into a system for recognizing underwater objects. The system is based on a combination of simulated dolphin sonar signals, simulated auditory filters and artificial neural networks. The system is tested on a cylinder wall thickness difference experiment and demonstrates high accuracy for small wall thickness differences. Results from the experiment are compared with results obtained by a false killer whale (pseudorca crassidens).
State test-anxiety, selective attention and concentration in university students (2014)

The principal aim of this study was to assess the level of selective attention and mental concentration before exams in a sample of university students and to determine a possible relationship between anxiety and reduction of levels of attention in this circumstance. A total of 403 university students, 176 men and 227 women, aged from 18 to 46 years, participated in the study. Of them, 169 were first-year undergraduates, 118 were second to fourth-year undergraduates and 116 were postgraduate Master's degree students. All of them completed the Spanish version of the Spielberger State-Anxiety Inventory and the D2 Attention Test just before taking an exam. Our results showed that participants with lower levels of anxiety had higher levels of selective attention and mental concentration before the exam. These results specifically indicate that when anxiety levels are very high, this could over-activate the orientating and alerting functions and to reduce the capacity of attentional control. These processes could have a negative impact on specific attentional processes and become a negative influence on performance in exams.
Cancer stem cells (2012)

Emerging data for the first time suggest CSCs may be responsible for relapse, even after BMT. However, BMT may be a particularly compelling setting to test CSC-targeting strategies because it provides the most effective clinical debulking of hematologic malignancies, and because CSC-targeting strategies may also enhance allogeneic antitumor immunity.
In Situ Solid-State NMR Observations of Photocatalytic Surface Chemistry:  Degradation of Trichloroethylene (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTIn Situ Solid-State NMR Observations of Photocatalytic Surface Chemistry: Degradation of TrichloroethyleneSon-Jong Hwang, Chris Petucci, and Daniel RafteryView Author Information Department of Chemistry, Purdue University 1393 Brown Laboratory of Chemistry West Lafayette, Indiana 47907 Cite this: J. Am. Chem. Soc. 1997, 119, 33, 7877–7878Publication Date (Web):August 20, 1997Publication History Received6 February 1997Revised27 May 1997Published online20 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/ja9703990https://doi.org/10.1021/ja9703990rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views561Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Degradation,Nuclear magnetic resonance spectroscopy,Oxides,Photocatalysts Get e-Alerts
Transposons: Molecular tools for genome investigation (2016)

Transposable elements are DNA sequences capable of moving or copying and reinserting themselves in the genome of a host cell. The Hermes DNA transposon was originally found in the housefly Musca domestica. Since its discovery, Hermes has been adapted to multiple eukaryotic species for random mutagenesis or mapping of chromatin structure. The Ty3 retrotransposons of S. cerevisiae is a long terminal repeat (LTR) mobile element of the gypsyâlike class. Ty3 is unique among retroelements for its highly specific targeting of RNAP3-transcribed genes for integration. In this dissertation, each of these mobile elements are utilized for different purposes. The Ty3 retrotransposon was used to investigate the relationship between integrase and host factors that direct insertion site selection. Ty3 integration events were quantitatively profiled genome-wide, demonstrating an unexplained bias within an already limited selection of RNAP3 targets. This bias was not defined by the host chromatin environment flanking target sites, and investigation of RNAP3 factors found poor agreement with Ty3 targeting bias. DNA sequence composition and structure of local target sequence were found to regulate integration frequency, in a motif-independent manner. The Hermes DNA transposon was used to establish a functional genomics system for the oleaginous yeast Yarrowia lipolytica, a quickly emerging and valuable microbe with many biotechnology applications. Identification of essential genes provides important information required for genome engineering. Hermes was used to mutagenize a population of Y. lipolytica. To classify essential and non-essential genes, transposon were profiled in surviving mutants by statistically testing under-representation of insertions relative to an expected number derived for each gene. The Y. lipolytica genome was categorized as 20.8 % essential, 71.1 % non-essential and 8.1 % poor essential. Many essential differed from S. cerevisiae, demonstrating the utility of a model obligate aerobe compared to current model yeasts. Pooled mutants were grown for 80 generations in glucose or glycerol, an industrial waste stream, to identify genes contributing to fitness. Glycerol media created a much more competitive environment than glucose. Gene classifications inform future metabolic studies by fine tuning flux analysis and genome scale models, while mutant libraries provide a pipeline for rescreening phenotypes relevant to industrial applications.
Apoptosis in Surgically Excised Choroidal Neovascular Membranes in Age-Related Macular Degeneration (1998)

Highly vascularized CNVMs related to age-related macular degeneration show apoptosis in stromal retinal pigment epithelial cells, endothelial cells, and occasional macrophages. Apoptosis is associated with prominent Fas and FasL expression.