gebhart/patrepeval huggingface dataset:
Post-exercise impact of ingested whey protein hydrolysate on gene expression profiles in rat skeletal muscle: activation of extracellular signal-regulated kinase 1/2 and hypoxia-inducible factor-1α (2014)

We have previously shown that whey protein hydrolysate (WPH) causes a greater increase in muscle protein synthesis than does a mixture of amino acids that is identical in amino acid composition. The present study was conducted to investigate the effect of WPH on gene expression. Male Sprague-Dawley rats subjected to a 2 h swimming exercise were administered either a carbohydrate-amino acid diet or a carbohydrate-WPH diet immediately after exercise. At 1 h after exercise, epitrochlearis muscle mRNA was sampled and subjected to DNA microarray analysis. We found that ingestion of WPH altered 189 genes after considering the false discovery rate. Among the up-regulated genes, eight Gene Ontology (GO) terms were enriched, which included key elements such as Cd24, Ccl2, Ccl7 and Cxcl1 involved in muscle repair after exercise. In contrast, nine GO terms were enriched in gene sets that were down-regulated by the ingestion of WPH, and these GO terms fell into two clusters, 'regulation of ATPase activity' and 'immune response'. Furthermore, we found that WPH activated two upstream proteins, extracellular signal-regulated kinase 1/2 (ERK1/2) and hypoxia-inducible factor-1α (HIF-1α), which might act as key factors for regulating gene expression. These results suggest that ingestion of WPH, compared with ingestion of a mixture of amino acids with an identical amino acid composition, induces greater changes in the post-exercise gene expression profile via activation of the proteins ERK1/2 and HIF-1α.
Medical Student Evaluation of the Quality of Hospitalist and Nonhospitalist Teaching Faculty on Inpatient Medicine Rotations (2004)

In addition to performing the responsibilities required of full-time hospital-based physicians, hospitalists were able to provide at least as positive an educational experience as did highly rated nonhospitalist teaching faculty and in some areas performed better. A hospitalist model can be an effective method of delivering inpatient education to medical students.
Olivanic acid analogues. Part 9. Allylic oxidative functionalisation of substituted azetidinones: synthesis of some 4-acyloxy-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylates (1991)

Sharpless oxidation (ButO2H, SeO2) of the protected allyl azetidinone 7 gave the allylic alcohol 8 which was transformed to the 5,6-trans-4α-acetoxyolivanic acid derivative 16. Kharasch–Sosnovsky benzoyloxylation (PhCO3But, CuCl, PhH, heat) of the silylated 7-azabicyclo[4.2.0]oct-3-enes 17b,c provided inter alia allylic benzoates 18b,c and 21b,c. These were synthetic precursors of the 5,6-cis-olivanic acid analogues 23 and 26, which contain 8- and 4α-benzoyloxy groups, respectively.
Perspectives on the male speech-language pathologist. (1994)

Although many professions are reporting greater gender neutrality, the opposite appears to be the case in speech-language pathology and audiology. The number of men in speech-language pathology and audiology has always been small. In 1925, 40% of the original members of the American Academy of Speech Correction were male (Bender, 1989). Each subsequent decade has seen the gender gap between male and female professionals widen (see chart illustrating the steady decline of male ASHA members between the years 1968 and 1992). When one considers only speech-language pathology, the gap between numbers of males and of females is even greater. According to ASHA's membership database, in December 1993 only 6.0% of ASHA-certified speech-language pathologists were men (ASHA, 1993).
Multibody Systems in Nonlinear Waves (1997)

Abstract Almost all offshore structures have to be modeled as multibody systems. Only ships or single pontoons can be modeled as a single rigid body. The dynamic behavior of the multibody system is significantly influenced by fluid-structure interactions. So far, most available methods for analyzing these interactions are restricted to single bodies, small wave amplitudes and body motions, or both. In the present paper a two-dimensional boundary integral approach with fully nonlinear boundary conditions on the free surface is used to simulate the behavior of elastically coupled floating multibody systems in gravity waves. This method will be applied to analyze the dynamics of two floating bodies moored to a quay. The results of numerical simulations for selected configurations are shown.
Low-temperature thermoluminescence (1976)

Technique for determining commonality of origin of materials is applicable to materials which are not solids at room temperature and heat-sensitive materials. Contamination of sample is avoided by using sealed sample cup. Technique is useful for determining origins of oil pollutants and has potential in mapping of lakes and/or oceans.
Bioactivity-Guided Metabolite Profiling of Feijoa (Acca sellowiana) Cultivars Identifies 4-Cyclopentene-1,3-dione as a Potent Antifungal Inhibitor of Chitin Synthesis (2018)

Pathogenic fungi continue to develop resistance against current antifungal drugs. To explore the potential of agricultural waste products as a source of novel antifungal compounds, we obtained an unbiased GC-MS profile of 151 compounds from 16 commercial and experimental cultivars of feijoa peels. Multivariate analysis correlated 93% of the compound profiles with antifungal bioactivities. Of the 18 compounds that significantly correlated with antifungal activity, 5 had not previously been described from feijoa. Two novel cultivars were the most bioactive, and the compound 4-cyclopentene-1,3-dione, detected in these cultivars, was potently antifungal (IC<sub>50</sub> = 1-2 μM) against human-pathogenic Candida species. Haploinsufficiency and fluorescence microscopy analyses determined that the synthesis of chitin, a fungal-cell-wall polysaccharide, was the target of 4-cyclopentene-1,3-dione. This fungal-specific mechanism was consistent with a 22-70-fold reduction in antibacterial activity. Overall, we identified the agricultural waste product of specific cultivars of feijoa peels as a source of potential high-value antifungal compounds.
Identification and Characterization of K+-Dependent Na+-Ca2+ Exchange Transport in Pigmented MEB4 Cells Mediated by NCKX4 (2016)

The SLC24 gene family encodes K(+)-dependent Na(+)-Ca(2+) exchangers or NCKX proteins. The NCKX4 and NCKX5 isoforms have been shown to be important for pigmentation, and single nucleotide polymorphism (SNP) in both alleles of the SLC24a5 gene is the major genetic determinant for light skin in Caucasians. NCKX4 is thought to operate in the surface membrane of cells, whereas NCKX5 is thought to be located in intracellular membranes. However, no functional data have yet been reported to describe either NCKX4 or NCKX5 activity in pigmented cells. In this study, we used the B16 and MEB4 mouse pigmented cell lines to investigate NCKX-mediated Ca(2+) fluxes using (45)Ca uptake experiments and measurements of changes in intracellular free Ca(2+) with the fluorescent Ca(2+)-indicating dye Fluo-4. We used siRNA-mediated knockdown to selectively reduce either NCKX4 or NCKX5 expression. The results show that both B16 and MEB4 cells contain roughly equal amounts of NCKX4 and NCKX5 transcript, but surface membrane NCKX activity is restricted to NCKX4. Intracellular NCKX4 activity was also observed, but we could not unambiguously detect any NCKX5 activity. We were able to demonstrate that NCKX5 is a functional K(+)-dependent Na(+)-Ca(2+) exchanger located in internal membranes after transfection of NCKX5 cDNA in HEK293 cells. We conclude that pigment cells express robust, functional NCKX4 activity, but that the role of NCKX5 remains enigmatic ten years after the discovery of its link to pigmentation.
Long-Term Effects of Non-Excitatory Cardiac Contractility Modulation Electric Signals on the Progression of Heart Failure in Dogs (2004)

In dogs with HF, long-term CCM therapy prevents progressive LV dysfunction and attenuates global LV remodeling. These findings provide compelling rationale for exploring the use of CCM for the treatment of patients with chronic HF.
Multipath Mitigation Techniques for Satellite-Based Positioning Applications (2012)

This is an open-access article licensed under a Creative Commons Attribution 3.0 Unported License.
Chain extenders for polyester. II. Reactivities of carboxyl‐addition‐type chain extenders; bis cyclic‐imino‐ethers (1986)

Abstract The reaction behavior of such bis cyclic‐imino‐ethers as 2, 2′‐bis(2‐oxazoline), which had been proved in the previous paper to be an effective chain extender to couple carboxyl terminals of linear polyesters through addition reaction, has been studied to evaluate their practical applicability as the chain extenders for poly(ethylene terephthalate) and poly(butylene terephthalate). It has been observed that a wide range of excess use of 2,2′‐bis(2‐oxazoline) resulted in polyesters of almost similar molecular weight. In addition, when excess amounts of the chain extender were added and the reaction conditions were fixed, the ratio of the coupled carboxyl terminals to the initial carboxyl terminals became constant regardless of the initial molecular weight and carboxyl content (CV). The results indicate that the chain‐extended polyesters possess predetermined molecular weight and CV, both of which depend only on the molecular weight and CV of the initial polymers, and not on the amount of the chain extender added.
914. Intramolecular aminolysis of amides (1958)

C. J. M. Stirling, J. Chem. Soc., 1958, 4531 DOI: 10.1039/JR9580004531
Timing of human sleep: recovery process gated by a circadian pacemaker (1984)

A model for the timing of human sleep is presented. It is based on a sleep-regulating variable (S)--possibly, but not necessarily, associated with a neurochemical substance--which increases during wakefulness and decreases during sleep. Sleep onset is triggered when S approaches an upper threshold (H); awakening occurs when S reaches a lower threshold (L). The thresholds show a circadian rhythm controlled by a single circadian pacemaker. Time constants of the S process were derived from rates of change of electroencephalographic (EEG) power density during regular sleep and during recovery from sleep deprivation. The waveform of the circadian threshold fluctuations was derived from spontaneous wake-up times after partial sleep deprivation. The model allows computer simulations of the main phenomena of human sleep timing, such as 1) internal desynchronization in the absence of time cues, 2) sleep fragmentation during continuous bed rest, and 3) circadian phase dependence of sleep duration during isolation from time cues, recovery from sleep deprivation, and shift work. The model shows that the experimental data are consistent with the concept of a single circadian pacemaker in humans. It has implications for the understanding of sleep as a restorative process and its timing with respect to day and night.
Disparities of National Lung Cancer Screening Guidelines in the US Population (2020)

Further consideration is needed to incorporate comprehensive risk factors, including race and ethnicity, into lung cancer screening to reduce potential racial disparities.
Outcomes of emergency transcatheter aortic valve replacement in patients with cardiogenic shock: A multicenter retrospective study (2022)

Rescue transcatheter aortic valve replacement (TAVR) in patients with cardiogenic shock is challenging, and there is limited literature on these critical patients. The aim of this study was to determine the characteristics and outcomes of patients undergoing TAVR, feasibility and safety of the procedure, and 1-year mortality factors. Thirty-eight patients with severe aortic disease and cardiogenic shock admitted to two French hospitals from 2015 to 2019 were included. The patients were critical, 78.9% of them had a left ventricular ejection fraction of <30%, and all of them received inotropic support. "Valve-in-valve" procedures were performed in 15.8% and 13.2% underwent balloon aortic valvuloplasty before TAVR. Edwards Sapien3® and Medtronic CoreValve EvolutR® were used. The survival probability remained reasonable for patients with cardiogenic shock who underwent rescue TAVR. The 30-day mortality rate was 7.9% and 21.1% at 1 year. No patient died during the intervention. The procedure was safe, with few complications except for acute kidney failure, the development of a left bundle branch block, and the need for pacemaker implantation. Both functional and echocardiographic results were good at 1 year, although 29% of the patients underwent rehospitalization within 1 year. The development of a left bundle branch block was found to be a mortality risk factor. This procedure is a safe and effective therapy with acceptable survivorship in critically ill patients. The benefits to their quality of life should be evaluated in future studies, and the need for providing early cardiac resynchronization therapy must be emphasized.
Monomers for Adhesive Polymers, 14 Synthesis and Radical Polymerization of 4-[11-(Acryloyl-methyl-amino)-undecyloxy]-phthalic Acid and {10-[1,3-Bis(methacrylamido)-propoxy]-decyloxy}-phthalic Acid (2014)

The polymerizable phthalic acid derivatives 4-[11-(acryloyl-methyl-amino)-undecyloxy]-phthalic acid (1) and {10-[1,3-bis(methacrylamido)-propoxy]-decyloxy}-phthalic acid (2) are synthesized from the MOM-ester of 4-hydroxy-phthalic acid and the corresponding bromo-alkyl-(meth)acrylamides. The synthesized monomers are characterized by 1H NMR, 13C NMR, and IR spectroscopy. The acrylamide 1 is insusceptible toward hydrolysis in aqueous media, strongly acidic and highly reactive in free radical polymerization. With these characteristics, 1 fulfills important requirements for the application in water-based single-bottle adhesive formulations. A deviation from the standard reaction kinetics is found for the free-radical homopolymerization of 1 in methanol with AIBN as initiator. The overall activation energy Ea is 66.2 kJ mol−1.
Approximate Factorization of Molecular Potential Surfaces II. Internal Rotors (2000)

Scaling models for the polyatomic potential energy surface occupy a ground intermediate between ab initio surfaces and random matrix models. They are useful for the study of vibrational energy redistribution (IVR) in large molecules, and have been shown to reproduce many features of more accurate spectroscopically fitted or
Preparation and Absorption Properties in Near Infrared Wavelength of Carbon Nanotubes/Acrylate Coatings (2007)

Carbon nanotubes can be used as absorbent materials at the near infared range. In this study, carbon nanotube was treated with surfactant to prevent aggregation, and the acrylate coating of the carbon nanotube was prepared with the carbon nanotube solution and the near infrared reflection properties of the coating were studied. A series of factors influencing the reflectivity of carbon nanotubes/acrylate coatings at 930 nm, such as PVC concentration, the kinds and concentration of the surfactant and size range of the carbon nanotube, were studied. Based on these, the coating procedure was optimized and the carbon nanotubes/acrylate coating was prepared with good absorption properties. The reflectivity is under 0.1% of the coatings and its transmission is below 1.0% at near infrared wavelength of 840980 nm.
Fuel ethanol production from Jerusalem artichoke stalks using different yeasts (1983)

The inulin-type sugars present in the stalks of Jerusalem artichoke (Helianthus tuberosus) were extracted with hot water and were used as a substrate to produce fuel EtOH. Seven different yeasts were used to obtain batch kinetic data. The medium consisted of stalk extract from Jerusalem artichoke containing 7.3% total sugars, supplemented with 0.01% oleic acid, 0.01% corn steep liquor, and 0.05% Tween 80. All batch fermentations were carried out in a 1-L bioreactor at 35 degrees and pH 4.6, and the following parameters were measured as a function of time: total sugars, EtOH and biomass concentration, maximum specific growth rate, and biomass and EtOH yields. The best EtOH producer was Kluyveromyces marxianus UCD (FST) 55-82 which gave an EtOH-to-sugar yield 97% of the theoretical maximum value, with almost 100% sugar utilization.
Object-based Linear Undo model (1997)

The simplicity of traditional linear undo model makes it easy to understand, easy to use and widely adopted in a lot of software products on the market. But the traditional linear undo model cannot support object-based recovery operations. In order to solve this problem, we propose the object-based linear undo model in this paper. In our model, the traditional linear recovery history is reorganized into main history and subhistories. The main history represents the sequence of interactive cycles. The subhistories record the operations on corresponding objects. Traditional linear undo mechanism is improved and applied to both main history and subhistories so that the main history can support traditional linear undo/redo operations and the subhistories can support object-based undo/redo operations. The object-based linear undo model has been implemented on the platform of TRIBASE, a UIMS system developed by SEIKO Instruments Incorporation.
A Comparison of Different Preparation Methods of Fe-Mo-Mg-O Catalyst for the Large-Scale Synthesis of Carbon Nanotubes (2006)

Carbon nanotubes (CNTs) in a high yield were synthesized by the decomposition of the methane gas with CCVD, in which two different reaction routes of sol-gel method prepared Fe-Mo- Mg-O catalyst. The two different routs influenced the wall number and defects of CNTs and the formation of CNTs. The concentration of Mo in the catalyst played a very important role in the yield of CNTs.
Synthesis and Amination of 4-Chloro-3-quinolinesulfonyl Chloride (1994)

Chlorinolysis of 4-chloro-3-benzylthioquinoline (2) or thioquinanthrene (1) using chlorine gas in the presence of water gave 4-chloro-3-quinol~nesulfonyl chloride (3).Amination of (3) performed in ether led to 4-chloro-3-quinolinesulfonamides (4).Reactions of compound (3) with an excess of primary or secondary amine in two phase (waterltoluene or benzene) system gave 4-(substituted amino)-3qu1nolinesulfonam1des (5) wlth two identical amine rests.While 4chloro-3quinolinesulfonamides (4) were aminated with an excess of amine Into aminosulfonamldes (5) with two identical or two various amine rests.
A case of anterior arch fracture of the atlas associated with C1 laminectomy (2023)

Neurosurgeons should be aware of the risk of anterior arch fractures following a CIL and may alternatively consider a C1 laminoplasty in the future.
Origin of Porosity in Triol Sol-Gel PbZr 53 Ti 47 O 3 Single Layer Thin Films Deposited on Pt/Ti/SiO 2 /Si Substrates (2002)

Pb(Zr 53 Ti 47 )O 3 thin films on Pt/Ti/SiO 2 /Si substrates were processed by a triol (1,1,1-tris(hydroxymethyl)ethane) based sol-gel route. Film microstructures were characterised using transmission electron microscope (TEM) equipped with electron energy loss spectroscopy and nano-probe energy dispersive X-ray analysis with the intention of revealing the crystallisation mechanism. Porosity developed in films >75nm, whereas films h 75nm thick were single phase and pore free. An investigation of low temperature heat treatment schedule on phase evolution was carried out to elucidate the origin of the porosity in films >75nm. TEM results indicated that porosity was associated with the formation of Pb-rich precipitates during low temperature pyrolysis (∼400°C). Inhomogeneity of the pyrolysed microstructure is responsible for inhomogeneity in the crystallised film >75nm.
Intelligent Connected Vehicles (2022)

Intelligent Connected Vehicle (ICV) is a typical automotive cyber-physical system (ACPS), which integrates sensing, computing, networks, and control functions. The functional safety-critical characteristics of ACPS determine that its automotive electronic system needs to meet confidentiality, integrity, and system availability. The development of the complexity and connectivity of modern automobiles has caused a massive rise in the security risks of the in-vehicle networks (IVNs), which poses great challenges for the safety guarantee of ACPS. Nevertheless, existing IVN designs lack cybersecurity consideration. Therefore, cybersecurity enhancement technology for in-vehicle networks has become a current research hotpot. In this chapter, the characteristics of intelligent connected vehicles and current in-vehicle network architecture are introduced, and the attack model and vulnerabilities of the current in-vehicle network are presented. Then the state-of-the-Art countermeasures of cybersecurity enhancement for IVN are introduced. At the end of this chapter, a discussion is given based on next-generation in-vehicle network architecture with security mechanisms and future research directions.
Immune responses of Helicoverpa armigera to different kinds of pathogens (2010)

These data suggest that the granulocytes are the major phagocytes in H. armigera. All haemocytes can be infected by AcMNPV. The transcripts of 14 immune related genes have different expression patterns in H. armigera infected by different pathogens, which means that the immune-related genes may have different functions against various kinds of pathogens.
P403Is programming ATP for slow ventricular tachycardia useful and safe? (2017)

Background: Implantable cardioverter-defibrillator (ICD) implantation is contraindicated in patients with less than a year life expectancy. However, many times answering this question is not easy. Clarifying predictors of death within a year will be very useful, especially if these predictors could be minimized or corrected. Purpose: Determine predictors of 1-year mortality after primary prevention ICD implantation. Methods: All consecutive patients who had implanted an ICD for primary prevention until 2015 were evaluated, including basal characteristics at the time of ICD implantation. Multivariate Cox-regression analysis was used to determine which factors are independently associated with 1-year mortality. Results: We studied 281 patients and 16 (5.6%) died within one year. Mean age was 64 6 11 years; 82% were male, 68% had ischemic heart disease, 63% were in New York Heart Association (NYHA) class II; 65% had hypertension; 46% diabetes mellitus; 66% dyslipidemia; 12% previous stroke; 47% atrial fibrillation and 14% obstructive pulmonary disease. In what concerns medical therapy, 92% of patients were receiving angiotensin-converting-enzyme inhibitor (ACEi) or angiotensin II receptor antagonists (ARBs); 86% beta-blockers (BB), 37% aldosterone receptor antagonists and furosemide (or equivalent) medium dose was 37 6 28 milligrams per day. Multivariate Coxregression analysis for 1-year mortality is presented in table.