gebhart/patrepeval huggingface dataset:
Orphan Nuclear Receptor Nurr1 as a Potential Novel Marker for Progression in Human Prostate Cancer (2013)

A number of studies have indicated that Nurr1, which belongs to a novel class of orphan nuclear receptors (the NR4A family), is important for carcinogenesis. Here we investigated expression of Nurr1 protein in benign and malignant human prostate tissues and association with clinicopathologic features using immunohistochemical techniques. Moreover, we also investigated the ability of Nurr1 to influence proliferation, migration, invasion and apoptosis of human prostate cancer cells using small interfering RNA silencing. Immunohistochemical analysis revealed that the expression of Nurr1 protein was higher in prostate cancer tissues than in benign prostate tissue (P < 0.001), levels being positively correlated with tumor T classification (P = 0.003), N classification (P = 0.017), M classification (P = 0.011) and the Gleason score (P = 0.020) of prostate cancer patients. In vitro, silencing of endogenous Nurr1 attenuated cell proliferation, migration and invasion, and induced apoptosis of prostate cancer cells. These results suggest that Nurr1 may be used as an indicator for prostate cancer progression and be useful for novel potential therapeutic strategies.
Pharmacokinetics of angiotensin converting enzyme inhibitors. (1989)

1. The pharmacokinetics of most ACE inhibitors have been evaluated indirectly by the measurements of plasma ACE activity and circulating levels of angiotensin I and II. 2. Although plasma ACE activity is very useful to study the degree and the time-course of ACE inhibition, one has to be aware that very different results can be obtained depending on the substrate employed in the assay. It is therefore impossible to compare the results of different inhibitors unless an identical methodology is used. 3. A clear dissociation between plasma angiotensin II levels and the antihypertensive effects of ACE inhibitors has been reported. This observation is in part linked to problems with the measurement of angiotensin II. New methods of determination of plasma angiotensin II have now allowed demonstration of the complete disappearance of plasma angiotensin II following acute ACE inhibition. During chronic treatment, however, angiotensin II generation is effectively blocked only during part of the day, but blood pressure remains controlled permanently. 4. Among the different pharmacokinetic characteristics of ACE inhibitors presently available, the route of excretion and to a lesser degree the half-life appear to be the most clinically relevant. However, the importance of the ability of ACE inhibitors to inhibit tissue renin-angiotensin systems remains to be defined.
Direct Inotropic Effects of Exogenous and Endogenous Urotensin-II (2009)

U-II modulates contractility independent of vasoconstriction with opposite effects in failing and nonfailing hearts. Positive inotropic responses to UT-A alone suggests that increased endogenous U-II constrains contractility in failing hearts via an autocrine or paracrine mechanism. These findings support a potential therapeutic role for UT-A in heart failure.
Micrometastases in Bone Marrow: Prognostic Indicators for Pancreatic Cancer (1999)

Minimal residual disease in patients with operable pancreatic carcinoma is frequently missed by current noninvasive tumour staging. We applied an immunocytochemical cytokeratin assay that allows identification of individual pancreatic carcinoma cells disseminated to bone marrow. Prior to therapy, bone marrow was aspirated from the upper iliac crest of 48 patients with ductal adenocarcinoma of the pancreas at various disease stages and an age-matched control group of 33 noncarcinoma patients. Tumor cells in cytologic bone marrow preparations were detected with monoclonal antibodies (mAbs) CK2, KL1, and A45-B/B3 to epithelial cytokeratins (CK) using the alkaline phosphatase antialkaline phosphatase method. CK-positive cells were found in 14 (48.4%) of 31 cancer patients treated with curative intent and in 10 (58.8%) of 18 patients with extended disease. The overall frequency of these cells was 1 to 83 per 5x10(5) mononuclear cells with no significant differences between patients at different tumor stages and lymph node involvement. After a median follow-up of 22.8 months (range 3-48 months), 6 (40.0%) of 15 patients who underwent complete surgical resection but had tumor cells in bone marrow presented with distant metastasis and 7 (46.7%) had local relapse compared to none of 12 corresponding patients without such cells (p<0.05). Univariate survival analyses revealed that the presence of CK-positive cells was predictive of reduced overall survival. In conclusion, anticytokeratin mAbs are reliable probes for the immunocytochemical detection of single pancreatic cancer cells disseminated to bone marrow. Thus the described technique may help identify patients with pancreatic cancer and at potentially high risk of early metastatic relapse. The results promise to be of important assistance for determining prognosis and the consequences in therapy of early stage pancreatic cancer.
Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element. (1990)

We have examined the binding of factors in rat liver nuclear extracts to the phosphoenolpyruvate carboxykinase (PEPCK) gene cyclic AMP (cAMP) response element (CRE) and other CREs and have isolated a rat liver CRE-binding protein (CREBP) cDNA. In addition, we have examined the influence of altering the phosphorylation state of nuclear factors on both CRE binding and in vitro transcription. Specific binding to the PEPCK CRE was measured in a mobility shift assay. CRE sequences of the PEPCK, somatostatin, and glycoprotein hormone alpha subunit genes competed equally for binding of rat liver nuclear factors to the PEPCK CRE, whereas mutant PEPCK CRE sequences did not compete for binding. Oligonucleotides complementary to rat pheochromocytoma CREBP (Gonzalez et al., Nature [London] 337:749-752, 1989) were used to prime rat liver and brain cDNA in the polymerase chain reaction. The predominant CREBP molecule obtained was identical to the rat pheochromocytoma CREBP except for a 14-amino-acid deletion in the N-terminal half that was also present in a human placental cDNA (Hoeffler et al., Science 242:1430-1433, 1988). The regulation of transcription by cAMP was examined by coincubation of rat liver nuclear extract with the purified catalytic subunit of cAMP-dependent protein kinase (protein kinase A). Although binding to the CRE was unaffected, in vitro transcription directed by the PEPCK promoter was stimulated by catalytic subunit, and this effect was blocked by protein kinase inhibitor peptide. In contrast, when nuclear extract was coincubated with phosphatase, there was substantial inhibition of in vitro transcription directed by the PEPCK promoter, but there was no effect on binding to the CRE. The major effects of catalytic subunit were exerted through the CRE, but residual stimulation was evident in promoter fragments containing only the TATA element. These data suggest that factors are bound to the CRE at constitutively high levels and that their capacity for transcriptional activation is regulated by phosphorylation.
A multi-feature fusion model based on BRB of health state prediction for aeroengine gas path system (2021)

The health of an aeroengine gas path system is essential to the reliable flight of the aircraft. Due to the complexity and coupling of aeroengine gas path systems, the establishment of a dynamic and comprehensive model for the health state prediction is difficult. It is very necessary to establish the prediction model by fusing multiple features instead of using a single feature such as exhaust temperature. A belief rule base (BRB) shows outstanding performance in modeling complex systems. This paper proposes a multi-feature fusion model based on BRB of health state prediction for aeroengine gas path system. In this model, firstly, the health characteristics of the aeroengine gas path system with different physical characteristics is taken. Secondly, a time series prediction model of the health characteristics based on BRB is established. Finally, the evidence reasoning (ER) algorithm is used to fuse these health characteristics to achieve the comprehensive health state prediction of the aeroengine gas path system. The BRB health state prediction model combines both quantitative information and expert knowledge to remedy deficiency of effective data and improve the prediction accuracy. Considering the initial parameters given by experts are subjective and may not be appropriate for engineering practice. The projection covariance matrix adaptive evolution strategy (P-CMA-ES) is selected as the optimization algorithm for training the initial parameters. Finally, a certain type of aeroengine is taken as a case to verify the effectiveness of the proposed model. The results show that the health state prediction model based on BRB with multi-feature fusion can accurately predict the health states of aeroengine gas path system.
Einfluss von Temperatur und Vorverformung auf das plastische Werkstoffverhalten von modernen Karosseriestählen (2004)

Abstract Im einem gemeinsam von der Automobil‐ und Stahlindustrie durchgeführten Projekt wurde das plastische Werkstoffverhalten von 20 Stählen für Feinblech beschrieben. Im Einzelnen wurden Fließkurven im quasistatischen Zugversuch bei den Temperaturen ‐40 °C, 23 °C und 100 °C sowohl im Anlieferungszustand als auch in verschiedenen Vorverformungs‐ und Wärmebehandlungszuständen ermittelt. Des Weiteren führten Versuche im Rahmen der technologischen Blechprüfung zu Grenzformänderungsschaubildern sowie zu Tiefzieh‐Arbeitsbereichen und Grenzziehverhältnissen. Die Ergebnisse der Zugversuche offenbarten signifikante Unterschiede zwischen einzelnen Stahlgruppen hinsichtlich ihres Verfestigungsverhaltens, das durch Verfestigungskurven und abgeleitete Kennwerte wie dem Streckgrenzenverhältnis R p0,2 /R m oder dem Θ IV ‐Wert beschrieben werden kann sowie deren Temperaturabhängigkeit. Das Projekt hat gezeigt, dass es innerhalb dieser definierten Stahlgruppen mit ähnlichem Verfestigungsverhalten grundsätzlich möglich erscheint, nur für wenige ausgewählte Zustände Fließkurven aufzunehmen und die Fließkurven von Stählen abweichender Festigkeit vorherzusagen. Dies ist eine wichtige Voraussetzung für die kostengünstige Bereitstellung von Eingabegrößen für eine numerische Werkstoff‐ und Bauteilmodellierung.
Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1in Mexican patients: A relationship between HLA and gender is suggested (2008)

This knowledge may contribute to a better understanding of the disease pathogenesis in different populations. The evaluation of the risk to develop narcolepsy-cataplexy in carriers of the described alleles/genotypes may also be possible. A larger sample should be analysed in Mexican and in other Hispanic patients to confirm these results.
Controlled Interconversion of a Dinuclear Au Species Supported by a Redox‐Active Bridging PNP Ligand Facilitates Ligand‐to‐Gold Electron Transfer (2017)

Redox non-innocent ligands have recently emerged as interesting tools to obtain new reactivity with a wide variety of metals. However, gold has almost been neglected in this respect. Here, we report mechanistic investigations related to a rare example of ligand-based redox chemistry in the coordination sphere of gold. The dinuclear metal-centered mixed-valent Au<sup>I</sup> -Au<sup>III</sup> complex 1, supported by monoanionic diarylamido-diphosphine ligand PNP<sup>Pr</sup> and with three chlorido ligands overall, undergoes a complex series of reactions upon halide abstraction by silver salt or Lewis acids such as gallium trichloride. Formation of the ultimate Au<sup>I</sup> -Au<sup>I</sup> complex 2 requires the intermediacy of Au<sup>I</sup> -Au<sup>I</sup> dimers 5 and 7 as well as the unique Au<sup>III</sup> -Au<sup>III</sup> complex 6, both of which are interconverted in a feedback loop. Finally, unprecedented ortho-selective C-H activation of the redox-active PNP ligand results in the carbazolyldiphosphine derivative PN*P<sup>Pr</sup> via ligand-to-metal two-electron transfer. This work demonstrates that the redox-chemistry of gold may be significantly expanded and modified when using a reactive ligand scaffold.
Answer Extraction Model Based on Named Entity Recognition (2014)

The answer extraction model has a direct impact on the performance of the Automatic Question Answering System (QA System). In this paper, an answer extraction model based on named entity recognition was presented. It mainly answers specific questions whose answers are related with the named entity. Firstly, it classified the questions according to answer types. And then it identified named entities with suitable types in the fragmented information. Finally, it got the final answer based on scores. The experiments in the paper proved that the model could accurately answer the questions provided by Text REtrieval Conference (TREC). Thus, the proposed model is easy to implement and its performance is good for specific questions.
4th September 2020 (2020)

4th September 2020 • Cottbus, GER Extradition Vigil for Julian Assange Location: Stadthalle Cottbus Time: 16:00-18:00 FB event: Contact: Friedenskoordination Cottbus and Attac Cottbus • Sydney, OZ Regular Gatherings in support of Julian Assange Location: Sydney Town Hall Time: 16:00
Ongoing Revolution in Bacteriology: Routine Identification of Bacteria by Matrix‐Assisted Laser Desorption Ionization Time‐of‐Flight Mass Spectrometry (2009)

MALDI-TOF mass spectrometry is a cost-effective, accurate method for routine identification of bacterial isolates in <1 h using a database comprising > or =10 reference spectra per bacterial species and a 1.9 identification score (Brucker system). It may replace Gram staining and biochemical identification in the near future.
Marburg Virus VP24 Protein Relieves Suppression of the NF–κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1 (2015)

mVP24 can relieve Keap1 repression of the NF-κB pathway through its interaction with Keap1.
From 1D Well Scale to 3D Seismic Scale Pore Pressure Prediction: Implication on Prospect Maturation (2020)

Summary Pore pressure prediction has been addressed for decades at the 1D well dimension. However, technology has evolved in the past 20 years and now numerous tools are available allowing to interpret geology in 2D or 3D. Pore pressure evolution through geological time and its spatial distribution is fundamentally a 3D (4D with time) problem. Basin modelling tools have been the first to give a visualisation of this. However, from basin modelling to well preparation the downscaling issue has been often a hindrance to spread its application, i.e. from hundreds of meters cell resolution to the meter resolution requested for Pore Pressure Prediction at well scale. Here we present the recent evolution of Pore Pressure Prediction workflow developed in Total integrating 3D tools to better assess the pore pressure evolution at a basin scale and help derisking prospect maturation and well preparation.
Modeling edge placement error distribution in standard cell library (2006)

In this work we present a predictive model for the edge placement error (EPE) distribution of devices in standard library cells based on lithography simulations of selective test patterns. Poly-silicon linewidth variation in the sub-100nm technology nodes is a major source of transistor performance variation (e.g., Ion and Ioff) and circuit parametric yield. It has been reported that significant part of the observed variation is systematically impacted by the neighboring layout pattern within optical proximity. Design optimization should account for this variation in order to maximize the performance and manufacturability of chip designs. We focus our analysis on standard library cells. In the past the EPE characterization was done on simple line array structures. However, the real circuit contexts are much more complex. Standard library cells offer a nice balance of usability by the designers and modeling complexity. We first construct a set of canonical test structures to perform lithography simulations using various OPC parameters and under various focus and exposure conditions. We then analyze the simulated printed image and capture the layout-dependent characteristics of the EPE distribution. Subsequently, our model estimates the EPE distribution of library cells based on their layout. In contrast to a straight-forward simulation of the library cells themselves, this approach is computationally less expensive. In addition the model can be used to predict the EPE distribution of any library cells and not limited to those that are simulated. Also, since the model encapsulates the details of lithography, it is easier for designers to integrate into design flow.
ChemInform Abstract: Ring Expansion of 2‐Alkylidenedihydroquinazolines to Iminodihydro‐1,4‐benzodiazepines by Methanesulfonyl and Trifluoromethanesulfonyl Azide. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Single-Amino-Acid Polymorphism in Chikungunya Virus E2 Glycoprotein Influences Glycosaminoglycan Utilization (2020)

Chikungunya virus (CHIKV) is a reemerging arbovirus responsible for outbreaks of infection throughout Asia and Africa, causing an acute illness characterized by fever, rash, and polyarthralgia. Although CHIKV infects a broad range of host cells, little is known about how CHIKV binds and gains access to the target cell interior. In this study, we tested whether glycosaminoglycan (GAG) binding is required for efficient CHIKV replication using CHIKV vaccine strain 181/25 and clinical isolate SL15649. Preincubation of strain 181/25, but not SL15649, with soluble GAGs resulted in dose-dependent inhibition of infection. While parental Chinese hamster ovary (CHO) cells are permissive for both strains, neither strain efficiently bound to or infected mutant CHO cells devoid of GAG expression. Although GAGs appear to be required for efficient binding of both strains, they exhibit differential requirements for GAGs, as SL15649 readily infected cells that express excess chondroitin sulfate but that are devoid of heparan sulfate, whereas 181/25 did not. We generated a panel of 181/25 and SL15649 variants containing reciprocal amino acid substitutions at positions 82 and 318 in the E2 glycoprotein. Reciprocal exchange at residue 82 resulted in a phenotype switch; Gly82 results in efficient infection of mutant CHO cells but a decrease in heparin binding, whereas Arg82 results in reduced infectivity of mutant cells and an increase in heparin binding. These results suggest that E2 residue 82 is a primary determinant of GAG utilization, which likely mediates attenuation of vaccine strain 181/25.
Microfluidic coaxial transmission line and phase shifter (2014)

ABSTRACT This article presents a microfluidic coaxial transmission line assembly that is realized by weaving together stretchable metallic fibers composed of a liquid‐metal core inside an elastomeric shell. These fibers are woven around a core fiber to create a coaxial assembly. The resulting structure exhibits exceptional stretchability compared to conventional coaxial transmission lines. The mechanical properties of the supporting elastomer and the fluidic properties of the conductors ensure that the characteristic impedance of the transmission line is maintained while stretched. As a result, the system is well suited for applications requiring durable transmission lines and tunable phase shifters (or time‐delay lines). A prototype fluidic coaxial structure is characterized that consists of eutectic gallium indium (EGaIn) encased in an elastomeric poly‐styrene‐(ethylene‐co‐butylene)‐styrene (SEBS). © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1459–1462, 2014
G Protein–Dependent and G Protein–Independent Signaling Pathways and Their Impact on Cardiac Function (2011)

G protein-coupled receptors signal through a variety of mechanisms that impact cardiac function, including contractility and hypertrophy. G protein-dependent and G protein-independent pathways each have the capacity to initiate numerous intracellular signaling cascades to mediate these effects. G protein-dependent signaling has been studied for decades and great strides continue to be made in defining the intricate pathways and effectors regulated by G proteins and their impact on cardiac function. G protein-independent signaling is a relatively newer concept that is being explored more frequently in the cardiovascular system. Recent studies have begun to reveal how cardiac function may be regulated via G protein-independent signaling, especially with respect to the ever-expanding cohort of β-arrestin-mediated processes. This review primarily focuses on the impact of both G protein-dependent and β-arrestin-dependent signaling pathways on cardiac function, highlighting the most recent data that illustrate the comprehensive nature of these mechanisms of G protein-coupled receptor signaling.
Front-End Structural Crash Energy Management Concept for a Sport Utility Like Aluminum Vehicle (2001)

Abstract Front-end structural concepts used to enhance the crash energy management of a sport utility like aluminum vehicle are discussed in this paper. These structural concepts were applied to the front-end rails, subframe, and subframe extension. Epoxy-based foam reinforcement was applied to the 5754 aluminum front end rails, shearing was applied to the cast-hydro formed tubular subframe, and a new load path was implemented in the front end structure in the form of a subframe extension. Deceleration-time response was developed and benchmarked against target double plateau square pulse at the early stage of the design. Vehicle front-end design and analysis for US-NCAP 35 mph full frontal crash were conducted using concept and detailed nonlinear finite element codes. Concept modeling tools that were used in the initial design stages involve collapsible nonlinear beam finite element, strength and stability, and spring mass system codes. Detailed finite element code RADIOSS was applied to the analysis of the final front-end structural design. Occupant responses and injury numbers were evaluated using MADYM03D rigid body and finite element code. Concept vehicle crash safety protection was evaluated and star-rated then benchmarked against 2000 and 2001 production SUVs. A paper study was conducted on a higher strength less ductile 6111T6 stamped aluminum alloy to further enhance the structure and enhance dash and floor intrusion. Structural collapse mode, deceleration-time response, and occupant simulation results show a good performance of aluminum front-end structures in managing crash energy and protecting vehicle occupants.
The mechanics of tack: Viscoelastic contact on a rough surface (2000)

This work considers the mechanics of tack in viscoelastic materials. We study a particular tack test in which a flat, rigid probe is brought into contact with the rough surface of a viscoelastic material. The rough surface is modeled as consisting of many spherical asperities of varying heights but all having the same radius. Because of the asperities, the apparent contact area can be much greater than the actual contact area, which is regarded as the key parameter that controls tack. We show how this actual contact area evolves with time under different loading conditions. Our formulation is different from previous theories in that it explicitly accounts for the fact that asperities of different heights are subjected to different loading histories. Explicit solutions are given for the cases of a constant load test, a load relaxation test, and a constant displacement rate test. © 2000 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 38: 1485–1495, 2000