gebhart/patrepeval huggingface dataset:
MULTIPLIER THEOREMS (1983)

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Soluble CD5 and CD6: Lymphocytic Class I Scavenger Receptors as Immunotherapeutic Agents (2020)

CD5 and CD6 are closely related signal-transducing class I scavenger receptors mainly expressed on lymphocytes. Both receptors are involved in the modulation of the activation and differentiation cell processes triggered by clonotypic antigen-specific receptors present on T and B cells (TCR and BCR, respectively). To serve such a relevant immunomodulatory function, the extracellular region of CD5 and CD6 interacts with soluble and/or cell-bound endogenous counterreceptors but also microbial-associated molecular patterns (MAMPs). Evidence from genetically-modified mouse models indicates that the absence or blockade of CD5- and CD6-mediated signals results in dysregulated immune responses, which may be deleterious or advantageous in some pathological conditions, such as infection, cancer or autoimmunity. Bench to bedside translation from transgenic data is constrained by ethical concerns which can be overcome by exogenous administration of soluble proteins acting as decoy receptors and leading to transient "functional knockdown". This review gathers information currently available on the therapeutic efficacy of soluble CD5 and CD6 receptor infusion in different experimental models of disease. The existing proof-of-concept warrants the interest of soluble CD5 and CD6 as safe and efficient immunotherapeutic agents in diverse and relevant pathological conditions.
A New Method For Snr-Estimation In Impulse Response Measurements (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009
The application of advanced image processing to rescue camera systems (2010)

Hand-held thermal imaging systems are an important tool for fire and rescue services conducting search and rescue tasks. However, in order to achieve wide-spread deployment the cost of such systems must be minimised, and this generally leads to reduced image quality. Within this paper the use of advanced image processing functions to increase the imaging system performance is discussed. Of particular note is the use and benefits of noise reduction and contrast enhancement. Results from a developed camera system are presented, and the performance gains are illustrated and discussed.
Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy (2013)

The notion that heart attacks develop from coronary-artery stenosis is an oversimplification of a process involving lipid metabolism, inflammation, macrophage activation, collagen breakdown, and plaque rupture. These insights are leading to new ideas for treatment and prevention.
Physical activity and its correlates in children: a cross-sectional study (the GINIplus & LISAplus studies) (2013)

When considering correlates of PA from several domains simultaneously, only few factors (sex, sports club membership, physical environment, time outdoors, and emotional symptoms) appear to be relevant. Although the causality needs to be ascertained in longitudinal studies, variables which cannot be modified should be used to identify risk groups while modifiable variables, such as sports club activities, may be addressed in intervention programs.
Surface-emitting second order distributed Bragg reflector laser with dynamic wavelength stabilization and far-field angle of 0.25° (1986)

Operation of a dynamically stabilized surface-emitting AlGaAs channeled-substrate-planar large-optical-cavity distributed Bragg reflector laser with a 0.25°×8° far-field pattern is reported. With 50% duty cycle and 50 ns–2 ms pulse length operation at room temperature, thresholds as low as 150 mA were obtained. No side modes were observed to 40 dB below the principal wavelength intensity under 100% modulation depth operation.
Quantifying and Reducing International Space Station Vulnerability Following Orbital Debris Penetration (1999)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Modification of hydroxyapatite by doping lithium through acid-base reaction (2022)

Lithium (Li) doping is increasingly regarded as an effective modification for hydroxyapatite (HA) due to its excellent performances in osteogenesis. However, traditional method involving calcium, lithium and phosphorus salt (salt route) usually brought some unexpected ions, which could influence the properties of the obtained materials largely. In the present study, acid-base reaction (acid-base route) was applied in a chemical co-precipitation method to achieve Li-doped HA in nano size (nLiHA) at various calcium to lithium ratios. Comparisons on structure and chemical composition between the nLiHA materials made from both routes (acid-base route and salt route) were subsequently conducted. As a result, synthesizing nLiHA through acid-base reaction was proved to be a feasible improvement on product purity and crystallinity.
Self-Supervised Global-Local Structure Modeling for Point Cloud Domain Adaptation with Reliable Voted Pseudo Labels (2022)

In this paper, we propose an unsupervised domain adaptation method for deep point cloud representation learning. To model the internal structures in target point clouds, we first propose to learn the global representations of unla-beled data by scaling up or down point clouds and then predicting the scales. Second, to capture the local structure in a self-supervised manner, we propose to project a 3D local area onto a 2D plane and then learn to reconstruct the squeezed region. Moreover, to effectively transfer the knowledge from source domain, we propose to vote pseudo labels for target samples based on the labels of their nearest source neighbors in the shared feature space. To avoid the noise caused by incorrect pseudo labels, we only select re-liable target samples, whose voting consistencies are high enough, for enhancing adaptation. The voting method is able to adaptively select more and more target samples during training, which in return facilitates adaptation because the amount of labeled target data increases. Experiments on PointDA (ModelNet-10, ShapeNet-10 and ScanNet-10) and Sim-to-Real (ModelNet-11, ScanObjectNN-11, ShapeNet-9 and ScanObjectNN-9) demonstrate the effectiveness of our method.
Disinfecting capabilities of oxychlorine compounds (1985)

The bacterial virus f2 was inactivated by chlorine dioxide at acidic, neutral, and alkaline pH values. The rate of inactivation increased with increasing pH. Chlorine dioxide disproportionation products, chlorite and chlorate, were not active disinfectants. As chlorine dioxide solutions were degraded under alkaline conditions, they displayed reduced viricidal effectiveness, thereby confirming the chlorine dioxide free radical as the active disinfecting species.
Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome (2011)

These findings suggest that the presence of asymptomatic spinal cord lesions place subjects with RIS at substantial risk for clinical conversion to either an acute or progressive event, a risk that is independent of brain lesions on MRI.
Process customization based on dependent topology in Software as a Service model (2010)

Software as a Service (SaaS) is a new software model for companies, which can provide them necessary software services based on a unique platform. In a general model of SaaS, the Independent Software Vendor (ISV) has a configurable and multi-tenant aware application. While in the actual working process, tenant always needs to do personal customization on different layers with individual requirements. To reduce the work in the process customization, this paper proposes a flexible process-customization program. By this program, tenant can customize the SaaS application from the processing layer on their own terms. To keep this process's validity and manage its generation, a topological algorithm based on the dependency of tasks is introduced. Experimental results show the efficiency of this algorithm.
Dimethyl sulfoxide-induced differentiation of Friend erythroleukemia cells in the absence of cytokinesis. (1979)

A crying infant labeled "Dingley Tariff" wears clothing labeled "Deficit from July 1st to Nov. 15th $44,411,144," and holds a tiny pair of pants labeled "Dingley Tariff." A man, possibly Nelson Dingley, holds a bolt of cloth labeled "New 'Protective' Measures" and a large pair of scissors and is standing next to the infant's high chair.
Cellular discrimination using in vitro Raman micro spectroscopy: the role of the nucleolus (2015)

Raman micro spectroscopy has attracted considerable attention over the last few years to explore its possible clinical applications as a non-invasive powerful label-free in vitro screening tool in cancer diagnosis and monitoring, subcellular analysis of biochemical processes, drug uptake, mode of action and mechanisms of interaction as well as toxicity of, for example, chemotherapeutic agents. However, in order to evaluate accurately the potential of Raman micro spectroscopy for such applications it is essential to optimise measurement and data processing protocols associated with subcellular analysis. To this end, in vitro differentiation of cell lines is a basic proof of concept for the potential of the technique, and although many studies have indicated successful differentiation based on Raman micro spectroscopy, it is important, as the measurement and processing techniques are improved, to establish the biochemical and subcellular basis of that discrimination. In this study, Raman micro spectroscopy is used to compare and differentiate normal and cancer cells from human lung origin, A549 adenocarcinoma cell line, Calu-1 epidermoid non-small-cell and BEAS-2B normal immortalized bronchial epithelium cell line. Spectra were taken from the three subcellular compartments, cytoplasm, nucleus and nucleolus and Principal Components Analysis was used to compare the spectral profiles between the cell lines and, coupled to Linear Discriminant Analysis, to explore the optimum sensitivity and specificity of discrimination. To support the analysis, Raman micro spectroscopy was coupled with Flow Cytometry, Confocal Laser Scanning Microscopy and Atomic Force Microscopy. While all subcellular regions can be employed to differentiate the normal and cancer cell lines, optimum discrimination sensitivity and specificity is achieved using the spectra from the nucleolar region alone. Notably, only the nucleolar spectral profiles differentiate the two cancer cell lines. The results point to the importance of the nucleolar regions in diagnostic applications of Raman microscopy as well as further applications in subcellular analysis of cytological processes.
Increased Palliative Care Referrals in Surgical Patients with Implementation of Interdisciplinary Mortality Council of Surgeons and Palliative Care Practitioners (2020)

Ling So, Alycia MD; Khetan, Prerna MS; Miller, Reba MBA; Marin, Michael L. MD, FACS; Maria Divino, Celia MD, FACS Author Information
The Pathophysiology of Skeletal Muscle Ischemia and the Reperfusion Syndrome: A Review (2002)

There are two components to the reperfusion syndrome, which follows extremity ischemia. The local response, which follows reperfusion. consists of limb swelling with its potential for aggravating tissue injury and the systemic response, which results in multiple organ failure and death. It is apparent that skeletal muscle is the predominant tissue in the limb but also the tissue that is most vulnerable to ischemia. Physiological and anatomical studies show that irreversible muscle cell damage starts after 3 h of ischemia and is nearly complete at 6 h. These muscle changes are paralleled by progressive microvascular damage. Microvascular changes appear to follow rather than precede skeletal muscle damage as the tolerance of capillaries to ischemia vary with the tissue being reperfused. The more severe the cellular damage the greater the microvascular changes and with death of tissue microvascular flow ceases within a few hours—the no reflow phenomenon. At this point tissue swelling ceases. The inflammatory responses following reperfusion varies greatly. When muscle tissue death is uniform, as would follow tourniquet ischemia or limb replantation, little inflammatory response results. In most instances of reperfusion, which follows thrombotic or embolic occlusion, there will be a variable degree of ischemic damage in the zone where collateral blood flow is possible. The extent of this region will determine the magnitude of the inflammatory response, whether local or systemic. Only in this region will therapy be of any benefit, whether fasciotomy to prevent pressure occlusion of the microcirculation, or anticoagulation to prevent further microvascular thrombosis. Since many of the inflammatory mediators are generated by the act of clotting, anticoagulation will have additional benefit by decreasing the inflammatory response. In instances in which the process involves the bulk of the lower extremity, amputation rather than attempts at revascularization may be the most prudent course to prevent the toxic product in the ischemic limb from entering the systemic circulation.
Ästhetische Erfahrung und Edition (2007)

At first glance, esthetic experience and editing appear to have very little in common. But even on such apparently safe ground as philological editing this impression turns out to be wrong. An editor who ignores the esthetic richness of the material he is working on may divert the attention of his edition's recipient away from essential features of the work of art in question. This collection is the fruit of a conference at which numerous editors and editing experts from various disciplines discussed the theoretical and practical consequences of such a constellation and their implications for the history of scholarship.
Numerical Investigation on the Size Effect of a WC/Co 3D Representative Volume Element Based on the Homogenized Elasto-Plastic Response and Fracture Energy Dissipation (2013)

Tungsten carbide-cobalt (WC/Co) is a two phase material composed of two distinct interpenetrating phases having different mechanical properties. The hard and brittle WC phase behaves elastically whereas the Co phase demonstrates an elasto-plastic response. In order to predict the global behavior of the material from its microscopic constitution, the representative volume element (RVE) model has to satisfy basic requirement of a certain size. Moreover the homogenized response of the RVE has to be characterized with respect to the macroscopic mechanical property of interest. Taking into consideration such phenomenon the current study investigates the size of 3D RVEs that are adequate to reflect the global elasto-plastic response and the fracture (damage) energy dissipation. The results of the homogenized elasto-plastic responses were compared to a macroscopic experimental stress-strain curve and the fracture energy dissipation was validated by a convergence study. It has been observed from the numerical simulation that, despite the randomness of the structure, the development of volume averaged elastic potential, plastic and as well as the fracture energy dissipation would stabilize with the increasing size of the RVE.
Rat and Rabbit Oral Developmental Toxicology Studies With Two Perfluorinated Compounds (2001)

Developmental toxicology (teratology) studies were done on two perfluorinated compounds-perfluorooctanesulfonate (PFOS) and 2-(N-ethylperfluorooctanesulfonamido)ethyl alcohol (N-EtFOSE) in rats and rabbits. Dose selection for these oral developmental toxicity studies were based upon dose-range study results. Dose levels of 0, 1, 5, 10, and 20 mg/kg/day were used for the rat N-EtFOSE study, and dose levels of 0, 0.1, 1.0, 2.5, and 3.75 mg/kg/day were used for both the PFOS and the N-EtFOSE rabbit studies. Although no compound-related deaths occurred in the dosed pregnant females on the developmental toxicity studies, maternal toxicity (reduced body weight gain and feed consumption) was present at higher dose levels in all three studies. At high maternally toxic doses, associated effects occurred in the conceptuses--increased abortions in PFOS and N-EtFOSE rabbits, reduced fetal weights in N-EtFOSE rats and PFOS rabbits, and increased late resorptions in N-EtFOSE rabbits. Detailed external gross, soft tissue, and skeletal fetal examinations failed to reveal any compound-related malformations in either species. Similar results, that is, only effects associated with maternal toxicity, had been found in previously conducted PFOS rat developmental toxicity studies. It was concluded that these perfluorinated compounds were not selective developmental toxicants in either rats or rabbits.
A phase 3 randomized study of pembrolizumab (pembro) plus lenalidomide (len) and low-dose dexamethasone (Rd) versus Rd for newly diagnosed and treatment-naive multiple myeloma (MM): KEYNOTE-185. (2018)

8010 Background: KEYNOTE-185 (NCT02579863) evaluated Rd ± pembro in patients (pts) with newly diagnosed, ASCT-ineligible MM. Methods: Pts were randomized 1:1 to pembro (200 mg Q3W) + Rd (len 25 mg [days (d) 1-21] + 40 mg dex [weekly] every 28d) vs Rd until progression (PD), unacceptable toxicity, or withdrawal. Randomization stratified by age ( < 75 vs ≥75 y), and disease stage (ISS I or II vs III). Primary end point was PFS per 2011 IMWG; secondary end points included OS and safety. On July 3, 2017, based on interim data presented to the DMC, the FDA halted KEYNOTE-185. Results: 301/640 pts enrolled (151, pembro-Rd; 150, Rd), with median (range) age: 74 y (53-89) vs 74 y (57-91); 24 (16%) pts in pembro-Rd am vs 10 (7%) pts in Rd arm had high-risk cytogenetics. Median (range) drug exposure was 131.0 d (1-485) in pembro-Rd arm vs 162 d (1-467) in Rd arm; median 6.0 cycles. AEs with ≥5% difference between arms: constipation, pyrexia, rash, vomiting, decreased appetite, pneumonia, oral candidiasis, pruritus, hypo-/hyperthyroidism. No SAEs with ≥5% difference between arms. In pembro + Rd arm, immune-mediated AEs (≥2%): hypothyroidism (7%), hyperthyroidism (6%), colitis (2%), and skin reactions (13%). 19 (13%) pts died in the pembro-Rd arm (6 from PD, 13 from AEs); 5/19 deaths were high risk. 9 (6%) pts died in the Rd arm (1 from PD, 8 from AE); 0/9 were high-risk. 6 (4%) treatment related deaths occurred; 4 (3%) [1 cardiac arrest, 1 pneumonia; 1 myocarditis, 1 cardiac failure]) were related to pembro. Median duration of follow-up was 6.4 mo vs 6.9 mo. Median TTP was not reached in either arm. Median PFS was not reached in either arm; HR, 1.22 (95% CI, 0.67-2.22); P= 0.75. Median OS was not reached in either arm; HR, 2.06 (95% CI, 0.93-4.55); P= 0.97. A retrospective random forest analysis and a subsequent multivariable Cox regression analysis led to no conclusive results due to the small number of death events ( < 10%) at time of analysis. Conclusions: Benefit-risk profile for combination of pembro-Rd is unfavorable for newly diagnosed MM. Evaluation of T-cell subsets and cytokines along with long-term safety and survival follow-up is ongoing. Clinical trial information: NCT02579863.
Interactive semi-automatic categorization for spinel group minerals (2015)

Spinel group minerals are excellent indicators of geological environments (tectonic settings). In 2001, Barnes and Roeder defined a set of contours corresponding to compositional fields for spinel group minerals. Geologists typically use this contours to estimate the tectonic environment where a particular spinel composition could have been formed. This task is prone to errors and requires tedious manual comparison of overlapping diagrams. We introduce a semi-automatic, interactive detection of tectonic settings for an arbitrary dataset based on the Barnes and Roeder contours. The new approach integrates the mentioned contours and includes a novel interaction called contour brush. The new methodology is integrated in the Spinel Explorer system and it improves the scientist's workflow significantly.
Resistance to hydrogen peroxide in Helicobacter pylori: role of catalase (KatA) and Fur, and functional analysis of a novel gene product designated ‘KatA-associated protein’, KapA (HP0874) (2002)

Helicobacter pylori infection elicits an aggressive inflammatory response that the bacterium is able to resist by virtue of its well-adapted antioxidant defence mechanisms. Catalase (KatA) appears to be a key enzyme in this resistance. Upstream of katA, a low-affinity ferric uptake regulator (Fur)-box has been identified. Downstream of katA, an ORF (HP0874) with no known function has also been identified. Non-polar isogenic mutants of katA, fur and HP0874 were constructed by allelic exchange. The impact of these mutations on the catalase activities and bacterial viability following exposure to hydrogen peroxide was studied. Concurrently, the effect of variation in the iron content of the media used to grow the cells was determined. The data showed that catalase-deficient isolates of H. pylori were hypersensitive to hydrogen peroxide, whereas wild-type cells could resist approximately approximately 100 mM hydrogen peroxide. Fur-deficient mutants and cells grown on low-iron-containing medium showed a distinct reduction in catalase activity and increased sensitivity to hydrogen peroxide. The data suggest a direct or indirect effect of Fur and iron on the activity of catalase. HP0874-deficient mutants showed no reduction in catalase activity but showed an increased sensitivity to hydrogen peroxide. That is, the protein encoded by HP0874 appears to have a role in resistance to hydrogen peroxide not directly related to catalase activity. This is the first report of a functional relationship of the product of this ORF. There is evidence of protein-protein interaction between KatA and the product encoded by HP0874, and the name 'KatA-associated protein' (KapA) is proposed.
Synthesizing third normal form relations from functional dependencies (1976)

It has been proposed that the description of a relational database can be formulated as a set of functional relationships among database attributes. These functional relationships can then be used to synthesize algorithmically a relational scheme. It is the purpose of this paper to present an effective procedure for performing such a synthesis. The schema that results from this procedure is proved to be in Codd's third normal form and to contain the fewest possible number of relations. Problems with earlier attempts to construct such a procedure are also discussed.
Closure to “Discussions of ‘The Optimum Design of Mechanical Systems With Competing Design Objectives’” (1974, ASME J. Eng. Ind., 96, pp. 1103–1104) (1974)

Second, fluids of the same viscosity be used (oil products).Third, arrive at some test to determine the wetting and spreading characteristics of the coolants when dropped onto sheets of metal at, say, 400-600 deg F.Fourth, investigate at what highest feed for a given speed, what pressure of the coolant is necessary to give optimum results.Personally, I am happy to see this type of investigation pursued, for I believe that continued research in this area (dynamic metal removal) is much more pertinent than the classical "lubrication studies" which are performed on primarily rubbed, but not cut, surfaces.