gebhart/patrepeval huggingface dataset:
Characterization ofgtf, a Glucosyltransferase Gene in the Genomes ofPediococcus parvulusandOenococcus oeni, Two Bacterial Species Commonly Found in Wine (2008)

"Ropiness" is a bacterial alteration in wines, beers, and ciders, caused by beta-glucan-synthesizing pediococci. A single glucosyltransferase, Gtf, controls ropy polysaccharide synthesis. In this study, we show that the corresponding gtf gene is also present on the chromosomes of several strains of Oenococcus oeni isolated from nonropy wines. gtf is surrounded by mobile elements that may be implicated in its integration into the chromosome of O. oeni. gtf is expressed in all the gtf(+) strains, and beta-glucan is detected in the majority of these strains. Part of this beta-glucan accumulates around the cells forming a capsule, while the other part is liberated into the medium together with heteropolysaccharides. Most of the time, this polymer excretion does not lead to ropiness in a model medium. In addition, we show that wild or recombinant bacterial strains harboring a functional gtf gene (gtf(+)) are more resistant to several stresses occurring in wine (alcohol, pH, and SO(2)) and exhibit increased adhesion capacities compared to their gtf mutant variants.
Ultra-Low Power Schottky Barrier TFT-Based Neurotransmitter Detection and Regenerative Studies (2022)

There is limited work on understanding Schottky barrier (SB) field-effect transistor (FET) behavior, and subsequent evolution of sensitivity metrics under wet detection conditions for neurotransmitter sensing applications. In this work, we report low-power deep subthreshold (DST) characteristics of SB InGaZnO<sub>4</sub> (IGZO) thin film transistors (TFTs) and implement this regime for sensitive and selective <i>ex vivo</i> detection of Dopamine against Adenosine Triphosphate (ATP). Device regeneration was performed under liquid solution environment over 34 days and sensor response was observed to drift less than two orders of magnitude. Nevertheless, the quantified trends due to buffer solution baseline versus target conjugation were virtually preserved across the TFTs. Widely improved detection metrics were extracted from the detection tests, namely the limit of detection (LoD) in the 100fM-100pM range, a binding affinity (<inline-formula> <tex-math notation="LaTeX">$k_{D}$ </tex-math></inline-formula>) between <inline-formula> <tex-math notation="LaTeX">$2.03\times 10^{-11}$ </tex-math></inline-formula>-<inline-formula> <tex-math notation="LaTeX">$3.02\times 10^{-9}\text{M}$ </tex-math></inline-formula> limits, and high sensitivity around 31-42mV/decade of target concentration. Although a steady drift with clear, repeatable differences between the device state at the start and end of the 34-day period were obtained, these devices were functional even after the regeneration test period. Such results can be used to estimate the regenerative lifetime of TFT biosensors under aptamer-immobilized solution environment detection conditions.
Polymerization of Guaiacol and a Phenolic β‐O‐4‐Substructure by Trameteshirsuta Laccase in the Presence of ABTS (2003)

The reaction of the monomeric lignin model compound guaiacol and the beta-O-4-type dimer erol (1-(4-hydroxy-3-methoxyphenyl)-2(2-methoxyphenoxy)-propane-1,3-diol with laccase from Trametes hirsuta was studied in the presence of the mediator ABTS (2,2'-azino-di[3ethylbenzothiazoline-6-sulfonic acid]). The product mixtures were analyzed by means of aqueous-phase size exclusion chromatography (SEC) with 50 mM NaOH as eluent. Interestingly, in the laccase-catalyzed reaction with both substrates, the mediator not only functioned as an electron carrier but underwent coupling reactions with the substrate to give polymeric coupling products. The molecular weight of these copolymeric products was significantly higher than the molecular weight of products obtained without ABTS. After ultrafiltration, 33% and 21% of the initially applied ABTS could be found in the polymeric product fraction for the substrates guaiacol and erol, respectively, on the basis of nitrogen analysis. When ABTS was added to substrates after full laccase-catalyzed polymerization, the reaction proceeded toward higher molecular weights.
Colleagues' Assistance Acknowledged by Temple (1977)

Journal Article Colleagues' Assistance Acknowledged by Temple Get access Michael R. Cohen, Michael R. Cohen Assistant Director, Pharmacy Service Temple University Hospital, Philadelphia, PA 19140 Search for other works by this author on: Oxford Academic Google Scholar Allan D. Marks, M.D. Allan D. Marks, M.D. Associate Professor of Medicine, Section of Endocrinology Temple University Hospital, Philadelphia, PA 19140 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 34, Issue 10, 1 October 1977, Page 1050, https://doi.org/10.1093/ajhp/34.10.1050a Published: 01 October 1977
Data from Alternate Metabolic Programs Define Regional Variation of Relevant Biological Features in Renal Cell Carcinoma Progression (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Clear cell renal cell carcinoma (ccRCC) has recently been redefined as a highly heterogeneous disease. In addition to genetic heterogeneity, the tumor displays risk variability for developing metastatic disease, therefore underscoring the urgent need for tissue-based prognostic strategies applicable to the clinical setting. We have recently employed the novel PET/magnetic resonance (MR) image modality to enrich our understanding of how tumor heterogeneity can relate to gene expression and tumor biology to assist in defining individualized treatment plans.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; ccRCC patients underwent PET/MR imaging, and these images subsequently used to identify areas of varied intensity for sampling. Samples from 8 patients were subjected to histologic, immunohistochemical, and microarray analysis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Tumor subsamples displayed a range of heterogeneity for common features of hypoxia-inducible factor expression and microvessel density, as well as for features closely linked to metabolic processes, such as GLUT1 and FBP1. In addition, gene signatures linked with disease risk (ccA and ccB) also demonstrated variable heterogeneity, with most tumors displaying a dominant panel of features across the sampled regions. Intriguingly, the ccA- and ccB-classified samples corresponded with metabolic features and functional imaging levels. These correlations further linked a variety of metabolic pathways (i.e., the pentose phosphate and mTOR pathways) with the more aggressive, and glucose avid ccB subtype.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Higher tumor dependency on exogenous glucose accompanies the development of features associated with the poor risk ccB subgroup. Linking these panels of features may provide the opportunity to create functional maps to enable enhanced visualization of the heterogeneous biologic processes of an individual's disease. &lt;i&gt;Clin Cancer Res; 22(12); 2950–9. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Efficient generation and multiplexing of optical orbital angular momentum modes in a ring fiber by using multiple coherent inputs (2012)

We propose an approach to efficiently generate and multiplex optical orbital angular momentum (OAM) modes in a fiber with a ring refractive index profile by using multiple coherent inputs from a Gaussian mode. By controlling the phase relationship of the multiple inputs, one can selectively generate OAM modes of different states l. By controlling both the amplitude and phase of the multiple inputs, multiple OAM modes can be generated simultaneously without additional loss coming from multiplexing. We show, by simulation, the generation of OAM modes (OAM state |l|<3) with mode purity greater than 99%. The power loss of generating and multiplexing seven modes is about 35%. A transmitter for an OAM-based mode-division multiplexing system is proposed based on the discrete Fourier transform between the data carried by the multiple inputs and the data carried by the OAM modes. The experimental implementation of the proposed approach could be achieved by integrating ring fiber, multicore fiber, and photonic integrated circuit technology.
Strain Property of Germanium Photonic Crystal Cavity on Silicon (2019)

Monolithic germanium on silicon 1 dimensional photonic crystal cavity is presented. Numerical simulation shows Q ∼ 100,000 for the cavity mode overlapped with strained germanium nanostructure. Raman measurement shows up to 1.5 % of uniaxial tensile strain at the center of the cavity.
Plectin-1 Targeted AAV Vector for the Molecular Imaging of Pancreatic Cancer (2013)

Pancreatic ductal adenocarcinoma (PDAC) is highly malignant disease that is the fourth leading cause of cancer-related death in the US. Gene therapy using AAV vectors to selectively deliver genes to PDAC cells is an attractive treatment option for pancreatic cancer. However, most AAV serotypes display a broad spectrum of tissue tropism and none of the existing serotypes specifically target PDAC cells. This study tests the hypothesis that AAV2 can be genetically re-engineered to specifically target PDAC cells by modifying the capsid surface to display a peptide that has previously been shown to bind plectin-1. Toward this end, a Plectin-1 Targeting Peptide (PTP) was inserted into the loop IV region of the AAV2 capsid, and the resulting capsid (AAV-PTP) was used in a series of in vitro and in vivo experiments. In vitro, AAV-PTP was found to target all five human PDAC cell lines tested (PANC-1, MIA PaCa-2, HPAC, MPanc-96, and BxPC-3) preferentially over two non-neoplastic human pancreatic cell lines (human pancreatic ductal epithelial and human pancreatic stellate cells). In vivo, mice bearing subcutaneous tumor xenografts were generated using the PANC-1 cell line. Once tumors reached a size of ∼1-2 mm in diameter, the mice were injected intravenously with luciferase reporter vectors packaged in the either AAV-PTP or wild type AAV2 capsids. Luciferase expression was then monitored by bioluminescence imaging on days 3, 7, and 14 after vector injection. The results indicate that the AAV-PTP capsid displays a 37-fold preference for PANC-1 tumor xenographs over liver and other tissues; whereas the wild type AAV2 capsid displays a complementary preference for liver over tumors and other tissues. Together, these results establish proof-of-principle for the ability of PTP-modified AAV capsids to selectively target gene delivery to PDAC cells in vivo, which opens promising new avenues for the early detection, diagnosis, and treatment of pancreatic cancer.
Pain management for the postoperative patient. (1994)

Studies have shown that patients often experience suboptimal analgesia in the postoperative period. In the past decade, a number of advances have been made to improve patient comfort after undergoing surgery. In addition to the obvious desirability of better pain control, adequate postoperative analgesia may decrease the incidence of cardiac and pulmonary complications. Opioid analgesics continue to be the main class of drugs used for postoperative analgesia. However, new methods and routes of administration, including patient-controlled analgesia and epidural and intrathecal drug administration, are currently being used. These modalities, when used appropriately, provide better analgesia, often with fewer side effects than when opiates are given by the traditional intramuscular route.
UWB communication for the human head (2012)

Ultra Wideband (UWB) technology is one of the promising technology for the Wireless Body Area Networks (WBANs), especially for the implanted one. The implanted device needs to be very small. Therefore, limitation on the implanted device size will put limitation on the antenna dimension, which will affect the antenna efficiency. It is necessary to know the propagation mechanism, as device is going to communicate from/to loosy media. we are presenting a theoretical studies on the UWB antenna to be used inside the human head for the frequency range of 3.1-10.6 GHz.
Clinical and laboratory markers of autosomal dominant polycystic kidney disease (ADPKD) progression: an overview. (2015)

Autosomal dominant polycystic kidney (ADPKD) is the most common inherited renal cystic disease and it occurs in all races, the reported prevalence is between 1:400 and 1:1000. It is characterized by development of cysts in both kidneys and progressive renal function loss. Among most Autosomal Dominant Polycystic Kidney patients, renal function remains intact until the fourth decade of life. It is very important to identify early markers of disease progression to recognize patients with a worse prognosis. The aim of this study is to review the clinical and laboratory markers of ADPKD progression. The early clinical parameters evaluated seem to be directly correlated with the volume of the cysts that determine the kidney volume. From a clinical point of view, total kidney volume (TKV) appears to be the best marker of early ADPKD progression. This review evaluated several ADPKD progression markers comparing the early consolidated clinical and the new promising laboratory indicators. From a laboratory point of view, copeptin has a potential role between the serum biomarkers of ADPKD progression. However, further studies are necessary to validate the potential predictive value of its serum level and to adopt it for routine use. The combination of biomarkers could probably predict ADPKD progression with more accuracy than the use of a single biomarker.
Rediscovering Multilayer Rigid-Flex with Z-interconnect Technology (2012)

Rigid-flex allows designers to replace multiple substrates interconnected with connectors, wires, and ribbon cables with a single package offering improved performance, reliability, and a potential cost-effective solution. However, processing and materials selection is critical in order to achieve high quality multilayer, rigid-flex structures. To date, there is no technology available which can economically produce high density multilayer rigid-flex with rigid or flex originating from any layer in the stack. In the present study, a novel strategy allowing for multi-layer rigid flex structures is reported. Specifically, metal-to-metal z-axis electrical interconnection among the flexible and rigid elements during lamination to form a single package rigid-flex structure is described. Conductive joints are formed during lamination using an electrically conductive adhesive (ECA). As a result, structures can be fabricated with multiple flexible elements at any arbitrary layer. Recent development work on flex joining using different pre-pregs is highlighted, particularly with respect to their integration in laminate chip carrier substrates, and the reliability of the joints formed between the rigid and flex surfaces. A variety of rigid-flex structures were fabricated, with 1 to 3 flex layers laminated into printed wiring board substrates. Photographs and optical microscopy were used to investigate the joining, bending, and failure mechanism. Several classes of flexible materials, including polyimides, PTFE, liquid crystal polymer (LCP), have been used to develop high-performance rigid-flex packages. Rigid-flex packages with embedded passives and actives are also being investigated.
Rational Design of Electrocatalytic Interfaces: Cd UPD Mediated Nitrate Reduction on Pd: Au Bimetallic Surfaces (2019)

Au surfaces modified by Pd electrodeposits have been found to enhance the rates of nitrate electroreduction in acidic aqueous solutions containing Cd2+ over those of the bare Au substrate in the same media. Rather surprisingly, similar electrocatalytic effects were also observed for ensembles of Au and Pd nanoparticles supported on otherwise inert glassy carbon (GC) surfaces under the same conditions, which suggest that this phenomenon does not originate solely from specific interactions between the two metals. In fact, the overall electrocatalytic activity of GC surfaces decorated with either a fixed number of Au in one case, or a fixed number of Pd nanoparticles in the other, displayed much lower activity than GC surfaces covered with a mixture of half of each of them. This unique behavior may be explained by the ability of Pd to reduce NO2−, which is known to be the main reaction product of NO3− reduction on underpotential deposited Cd on Au.
A system of array families and synthesized soft arrays for the POWER9™ processor in 14nm SOI FinFET technology (2017)

The POWER9™ Processor in 14 nm SOI FinFET technology makes use of 7 different families of arrays. This paper gives an overview on advantages of different implementations, focusing on two key innovations introduced with this processor generation: Fast and low-latency write assist schemes for single-voltage performance arrays, as well as a new methodology, the synthesized soft arrays, to enable significant improvements for small array structures in both area and design efficiency.
Aktualisierte S2k-Leitlinie chronische Obstipation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie & Motilität (DGNM) – April 2022 – AWMF-Registriernummer: 021–019 (2022)

Abkürzungsverzeichnis AST: Aspartat-Aminotransferase ALT: Alanin-Aminotransferase BFI: bowel function index CACP: Chirurgische Arbeitsgemeinschaft für Coloproktologie CAS: constipation assessment Skala (scale) CSBM: komplette spontane Stuhlentleerung (complete spontaneous bowel movement) DEGAM: Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin DGAV: Deutsche Gesellschaft für Allgemein- und Viszeralchirugie DGEM: Deutsche Gesellschaft für Ernährungsmedizin DGG: Deutsche Gesellschaft für Geriatrie DGIM: Deutsche Gesellschaft für Innere Medizin DGK: Deutsche Gesellschaft für Koloproktologie DGNHK: Deutsche Gesellschaft für Naturheilkunde DGNM: Deutsche Gesellschaft für Neurogastroenterologie & Motilität DGP: Deutsche Gesellschaft für Palliativmedizin DGVS: Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten EFSA: Europäische Behörde für Lebensmittelsicherheit 5-HT4-Antagonisten: 5-Hydroxytryptamin-Rezeptor-Antagonisten ICC: Interstitielle Cajal-Zelle GINMP: gastrointestinale neuromuskuläre Pathologien GIT: Gastrointestinaltrakt KHK: koronare Herzkrankheit MACE: Malone antegrade continence enema MAGDA: Informationsforum für Magen-Darm-Erkrankungen MRT: Magnetresonanztomographie NPV: negativer prädiktiver Wert NTC: Normaltransit-Obstipation (normal transit constipation) OD: obstruktive Defäkation ODS: obstruktives Defäkations-Syndrom OIC: Opoid-/Opiat-induzierte Obstipation (opoid-induced constipation) PAC-QOL: Patient Assessment of Constipation Quality of Life PAMORA: peripher wirksamer µ-Opioid-Rezeptorantagonist (peripherally acting µ-opioid receptor antagonist) PEG: Polyethylenglycol PNE: perkutane Nervenevaluation RDS-O: obstipationsdominantes Reizdarmsyndrom RCT: randomisiert kontrollierte Studie (randomized controlled trial) scFOS: Fructooligosaccharide SNS: sakrale Nervenstimulation STC: Obstipation mit verzögertem Colontransit (slow transit constipation) TCM: traditionelle chinesische Medizin TES: transcutaneous electrical stimulation TSH: Thyreoidea-stimulierendes Hormon SBM: spontane Stuhlentleerung (spontaneous bowel movement)
Using OMPS-LP color ratio to extract stratospheric aerosol particle size and concentration with application to volcanic eruptions (2023)

Abstract. We develop an algorithm that uses the aerosol extinction at two wavelengths (color ratio) to derive the size and number density for stratospheric aerosols. We apply our algorithm to Ozone Mapping Profiler Suite Limb Profiler (OMPS-LP) L2 and Stratospheric Aerosol and Gas Experiment (SAGE) data. We show that the color ratio between two wavelengths (e.g. 510 nm/869 nm) is insensitive to aerosol concentration and thus can be used to derive aerosol size assuming a log-normal size distribution. With the size and the extinction, we can compute a number density consistent with both wavelengths. Our results compare favorably to balloon borne particle size and concentration measurements. Our results are also consistent with SAGE solar occultation measurements. Finally, we show the background distribution of stratospheric aerosols and the changes in those distributions during the Reikoke and Hunga Tonga-Hunga Ha’apai volcanic eruptions. We also show the evolution of the size and number density of aerosols following both of those eruptions.
Applying Virtual Inertia Control Topology to SMES System for Frequency Stability Improvement of Low-Inertia Microgrids Driven by High Renewables (2019)

To integrate renewable energy into microgrids with a favorable inertia property, a virtual inertia control application is needed. Considering the inertia emulation capabilities, insufficient emulation of inertia power due to the lower and short-term power of storage systems could significantly cause system instability and failure. To enhance such capability, this paper applies a virtual inertia control topology to the superconducting magnetic energy storage (SMES) technology. The SMES-based virtual inertia control system is implemented in a microgrid with renewables to emulate sufficient inertia power and maintain good system frequency stability. The efficacy and control performance of the proposed control method are compared with those of the traditional virtual inertia control system. Simulation results show that the shortage of system inertia due to renewable penetration is properly compensated by the proposed control method, improving system frequency stability and maintaining the robustness of system operations.
Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis (2015)

OSS impairs autophagic flux to interfere with mitochondrial homeostasis. Antioxid. Redox Signal. 23, 1207-1219.
ChemInform Abstract: Synthesis and Crystal Structure of the New High‐Pressure Phase CdB2O4. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Reviewing the current classification of inhibitor of growth family proteins (2009)

Inhibitor of growth (ING) family proteins have been defined as candidate tumor suppressors for more than a decade. Recent emerging results using siRNA and knockout mice are expanding the previous understanding of this protein family. The results of ING1 knockout mouse experiments revealed that ING1 has a protective effect on apoptosis. Our recent results showed that ING2 is overexpressed in colorectal cancer, and induces colon cancer cell invasion through an MMP13-dependent pathway. Knockdown of ING2 by siRNA induces premature senescence in normal human fibroblast cells, and apoptosis or cell cycle arrest in various adherent cancer cells. Taken together, these results suggest that ING2 may also have roles in cancer progression and/or malignant transformation under some conditions. Additionally, knockdown of ING4 and ING5 by siRNA shows an inhibitory effect on the transition from G(2)/M to G(1) phase and DNA replication, respectively, suggesting that these proteins may play roles during cell proliferation in some context. ING family proteins may play dual roles, similar to transforming growth factor-beta, which has tumor suppressor-like functions in normal epithelium and also oncogenic functions in invasive metastatic cancers. In the present article, we briefly review ING history and propose a possible interpretation of discrepancies between past and recent data.