gebhart/patrepeval huggingface dataset:
Mechanism and kinetics of the silane decomposition in the presence of acetylene and in the presence of olefins (1985)

Abstract Kinetic data and product studies are reported for the silane pyrolysis in the presence of olefins and acetylene. The kinetics of silane loss in the presence of acetylene was found to be identical to the initial gas phase silane decomposition step (SiH 4 + M → SiH 2 + H 2 + M) when corrected for pressure fall‐off effects. This result and the absence of methane or ethane from the pyrolysis of SiH 4 in the presence of 1‐butene or 1‐pentene demonstrate that silyl radicals and H atoms are not involved in silane‐olefin or silane‐acetylene reactions. Qualitative aspects and kinetic data from the SiH 4 pyrolysis in the presence of propylene are in accord with propylsilane formation via propylsilylene formed by silylene addition to propylene.
The Proteins of mRNA Modification: Writers, Readers, and Erasers (2023)

Over the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled in large part by the development of tools for detecting RNA modifications transcriptome wide, researchers have uncovered a diverse epitranscriptome that serves as an additional layer of gene regulation beyond simple RNA sequence. Here, we review the proteins that write, read, and erase these marks, with a particular focus on the most abundant internal modification, <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A). We first describe the discovery of the key enzymes that deposit and remove m<sup>6</sup>A and other modifications and discuss how our understanding of these proteins has shaped our views of modification dynamics. We then review current models for the function of m<sup>6</sup>A reader proteins and how our knowledge of these proteins has evolved. Finally, we highlight important future directions for the field and discuss key questions that remain unanswered.
GABA, Its Receptors, and GABAergic Inhibition in Mouse Taste Buds (2011)

Taste buds consist of at least three principal cell types that have different functions in processing gustatory signals: glial-like (type I) cells, receptor (type II) cells, and presynaptic (type III) cells. Using a combination of Ca2+ imaging, single-cell reverse transcriptase-PCR and immunostaining, we show that GABA is an inhibitory transmitter in mouse taste buds, acting on GABA(A) and GABA(B) receptors to suppress transmitter (ATP) secretion from receptor cells during taste stimulation. Specifically, receptor cells express GABA(A) receptor subunits β2, δ, and π, as well as GABA(B) receptors. In contrast, presynaptic cells express the GABA(A) β3 subunit and only occasionally GABA(B) receptors. In keeping with the distinct expression pattern of GABA receptors in presynaptic cells, we detected no GABAergic suppression of transmitter release from presynaptic cells. We suggest that GABA may serve function(s) in taste buds in addition to synaptic inhibition. Finally, we also defined the source of GABA in taste buds: GABA is synthesized by GAD65 in type I taste cells as well as by GAD67 in presynaptic (type III) taste cells and is stored in both those two cell types. We conclude that GABA is an inhibitory transmitter released during taste stimulation and possibly also during growth and differentiation of taste buds.
Multi-ampere metal ion source (2003)

A new embodiment of the MEVVA (metal vapor vacuum arc) ion source has been constructed with which pulsed metal ion beams of current in the range 1-10 A can be produced. The source efficiency (ratio of beam current to arc current) has been increased and the ion beam current raised by an order of magnitude, by allowing the plasma to expand to a large diameter and forming the beam with a set of large-area extractor grids. Preliminary test results are presented. In a simplified configuration, the source can provide a beam at over 90 kV and with a pulsed beam current of 2 A.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Saudi Association for the Study of Liver diseases and Transplantation practice guidelines on the diagnosis and management of hepatocellular carcinoma (2020)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
New Methodology for the Synthesis of α,α-difluoroketones (2008)

Abstract A new methodology is described for the synthesis of α,α-difluorinated ketones by the addition of organolithium reagents to α,α-difluoro-N-methoxy-N-methyl amides (Weinreb amides). Keywords: α,α-Difluoroketonesα,α-Difluoro-N-methoxy-N-methyl amidesPyruvic acid ACKNOWLEDGMENTS We thank Drs. Arthur Taveras, T. K. Sasikumar, Robert Aslanian, and John Piwinski from Schering-Plough Research Institute (SPRI). We also thank the NMR and mass spectral groups of SPRI for spectral data.
Impaired cognitive empathy in criminal psychopathy: Evidence from a laboratory measure of empathic accuracy. (2012)

Empathy deficits feature prominently in theoretical accounts of psychopathy, yet studies that have examined various aspects of emotional processing related to empathy have produced a mixed body of findings. We created a laboratory measure of cognitive empathy based on the empathic accuracy paradigm (i.e., the ability to accurately infer others' emotions in a simulated interpersonal interaction) and used it to examine relationships between psychopathy (assessed with the Psychopathy Checklist-Revised) and cognitive empathy in a sample of incarcerated male offenders. Psychopathy was inversely associated with empathic accuracy performance, as well as with the number of responses when rating the emotional states of others. Empathic accuracy performance was most strongly associated with the behavioral/antisocial and lifestyle features of psychopathy. When the emotional content of target vignettes was examined, psychopathy was associated with poorer empathic accuracy for negatively valenced emotions only (fear and sadness), although nonsignificant moderate effect sizes were also observed for joy. Whereas the interpersonal/affective factor of psychopathy was associated with poor empathic accuracy for joy, the behavioral/antisocial factor was associated with poor overall empathic accuracy for negatively valenced emotions. At the psychopathy facet level, the interpersonal and lifestyle features of psychopathy were associated with poor empathic accuracy for positively valenced emotions, whereas the affective and antisocial features of psychopathy were inversely associated with empathic accuracy for negatively valenced emotions. In contrast to its association with poor empathic accuracy performance, psychopathy was not associated with ratings of perceived task difficulty.
Design techniques for very high speed digital delta-sigma modulators aimed at all-digital RE transmitters (2006)

This paper presents a very high-speed delta-sigma modulator for achieving digital generation of radio-frequency signals. About 68 dB of ACLR (adjacent channel leakage ratio) is obtained on the 7.8 GS/s output of the delta-sigma modulator for WCDMA standard. This is achieved by using original concepts like borrow-save arithmetic, non-exact quantization and differential dynamic logic.
The inner rod of virulence‐associated type III secretion systems constitutes a needle adapter of one helical turn that is deeply integrated into the system's export apparatus (2019)

Type III secretion injectisomes are essential virulence factors for many pathogenic bacteria by mediating the transport of effector proteins into eukaryotic host cells. The secretion conduit of injectisomes is formed by a helical assembly of three hydrophobic proteins (SctR, SctS and SctT), an inner rod (SctI) and a needle filament (SctF). SctI is thought to play a role in switching between the secretion of different substrate classes and assembly of the inner rod has been implicated in regulating the length of the needle filament. While high-resolution structures of the hydrophobic components and of the needle filament have been solved, little is known about the structure and the assembly of the inner rod, which impedes the deeper assessment of its function. Here we show by exhaustive in vivo photocrosslinking that SctI engages in extensive interactions with SctR and SctT throughout its entire length. Our data imply that the inner rod serves as an adapter between the export apparatus and the needle filament by forming one helical turn. We show that assembly of the inner rod does not play a role in needle length control nor in substrate specificity switching. Instead, our findings imply that inner rod assembly must precede assembly of the needle filament.
Relation between COD and J-Integral in Generally Yielded Rigid-Plastic Body (1981)

曲げ, 小形引張り, 片側き裂および中央き裂を持つ引張試験片のおのおのに対して, 剛塑性変形を仮定して全面降伏後のCODとJ積分の関係について考察を行なった. その結果これらすべてに対して小規模降伏の場合と同様にJ=λσYσ ( σ:き裂開口変位, COD, σY:引張降伏応力)の関係のあることが示された. ここにλの値はき裂先端の塑性拘束に依存することが明らかにされ, 各試験片に対してその具体的な値が求められた.
ETV6‐LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98‐HOXA9 (2015)

ETV6, which encodes an ETS family transcription factor, is frequently rearranged in human leukemias. We show here that a patient with acute myeloid leukemia with t(7;11)(p15;p15) gained, at the time of relapse, t(11;12)(q12.1;p13) with a split ETV6 FISH signal. Using 3'-RACE PCR analysis, we found that ETV6 was fused to LPXN at 11q12.1, which encodes leupaxin. ETV6-LPXN, an in-frame fusion between exon 4 of ETV6 and exon 2 of LPXN, did not transform the interleukin-3-dependent 32D myeloid cell line to cytokine independence; however, an enhanced proliferative response was observed when these cells were treated with G-CSF without inhibition of granulocytic differentiation. The 32D and human leukemia cell lines each transduced with ETV6-LPXN showed enhanced migration towards the chemokine CXCL12. We show here for the first time that LPXN is a fusion partner of ETV6 and present evidence indicating that ETV6-LPXN plays a crucial role in leukemia progression through enhancing the response to G-CSF and CXCL12.
Contrasting Host-Parasite Population Structure: Morphology and Mitogenomics of a Parasitic Flatworm on Pelagic Deepwater Cichlid Fishes from Lake Tanganyika (2021)

Little phylogeographic structure is presumed for highly mobile species in pelagic zones. Lake Tanganyika is a unique ecosystem with a speciose and largely endemic fauna famous for its remarkable evolutionary history. In bathybatine cichlid fishes, the pattern of lake-wide population differentiation differs among species. We assessed the congruence between the phylogeographic structure of bathybatine cichlids and their parasitic flatworm <i>Cichlidogyrus casuarinus</i> to test the magnifying glass hypothesis. Additionally, we evaluated the use of a PoolSeq approach to study intraspecific variation in dactylogyrid monogeneans. The lake-wide population structure of <i>C. casuarinus</i> ex <i>Hemibates stenosoma</i> was assessed based on a portion of the <i>cox</i>1 gene combined with morphological characterisation. Additionally, intraspecific mitogenomic variation among 80 parasite samples from one spatially constrained metapopulation was assessed using shotgun NGS. While no clear geographic genetic structure was detected in parasites, both geographic and host-related phenotypic variation was apparent. The incongruence with the genetic north-south gradient observed in <i>H. stenosoma</i> may be explained by the broad host range of this flatworm including eupelagic bathybatine host species that form panmictic populations across the lake. In addition, we present the first parasite mitogenome from Lake Tanganyika and propose a methodological framework for studying the intraspecific mitogenomic variation of dactylogyrid monogeneans.
The U.S.-Japanese Alliance Redefined: Implications for Security in the Taiwan Strait (2005)

The U.S-Japan alliance was the cornerstone for U.S. strategic posture in the Asia-Pacific and the regions peace and' security during the Cold War. However, success bred complacency, as alliance became adrift. The end of the Cold War, heightened bilateral trade frictions, and new security challenges, such as a rising China, a nuclear-armed North Korea, and terrorism necessitated a reevaluation of this important relationship. This article examines the redefined U.S-Japan alliance and especially the implications of the 1997 Revised Guidelines for the U.S-Japan Defense Cooperation and the 2005 "Two Plus Two" Talks for a military contingency in the Taiwan Strait. It will examine the special role that Okinawa plays in the US. security strategy in the region.
MacDonnell, the Boards and the 1928 Act (2003)

The Reorganisation of Offices (Scotland) Act, 1928 partially enacted the recommendations of the Royal Commission on the Civil Service (MacDonnell) and the Machinery of Government Committee (Haldane), each calling for Scottish administration to be modelled on Whitehall. But it was not until 1939 that the Scottish central administration was finally constituted on Whitehall lines with the dissolution of most of the remaining boards. The 1928 Act was passed fourteen years after the MacDonnell Commission and ten years after the Haldane Committee had issued reports. Bills were presented in 1923, 1924 and 1927 before an Act was passed in 1928; each bill had gone further than that of its predecessor towards a full implementation of a scheme consistent with the Whitehall model. The long wait was due to the lack of urgency attached to the measure, the desirability of which seemed to increase. Notably, the Act was passed at a convenient time when a large number of board members were about to retire and a year before a major overhaul of local government in Scotland. Nevertheless the case against the boards in Scotland had been assembled long before they were dismantled.
Minaprine, but not oxiracetam, prevents desipramine-induced impairment of avoidance learning in mice. (1995)

The tricyclic antidepressant desipramine impaired shuttle-box avoidance acquisition in mice of the CD-1 strain. The nootropic drug oxiracetam was unable to prevent the desipramine-induced learning impairment, while a protective action was exerted by minaprine, a psychotropic agent regarded as an atypical antidepressant drug, possessing dopaminergic and related memory-enhancing properties. It seems likely that the dopaminergic action of minaprine played a determinant role in its avoidance improving effects in desipramine treated mice, because similar effects were produced by amphetamine. However, in contrast to amphetamine, minaprine did not enhance locomotor activity and did not show signs of general behavioral stimulation.
B16-BL6 melanoma cells release inhibitory factor(s) of active pump activity in isolated lymph vessels (2001)

We investigated whether supernatant cultured with melanoma cell lines B16-BL6 and K1735 or the Lewis lung carcinoma cell line (LLC) can regulate lymphatic pump activity with bioassay preparations isolated from murine iliac lymph vessels. B16-BL6 and LLC supernatants caused significant dilation of lymph microvessels with cessation of pump activity. B16-BL6 supernatant produced dose-related cessation of lymphatic pump activity. There was no significant tachyphylaxis in the supernatant-mediated inhibitory response of lymphatic pump activity. Pretreatment with 3 x 10(-5) M N(omega)-nitro-L-arginine methyl ester (L-NAME) or 10(-7) M or 10(-6) M glibenclamide and 5 x 10(-4) M 5-hydroxydecanoic acid caused significant reduction of supernatant-mediated inhibitory responses. Simultaneous treatment with 10(-3) M L-arginine and 3 x 10(-5) M L-NAME significantly lessened L-NAME-induced inhibition of the supernatant-mediated response, suggesting that endogenous nitric oxide (NO) plays important roles in supernatant-mediated inhibitory responses. Chemical treatment dialyzed substances of <1,000 molecular weight (MW), producing complete reduction of the supernatant-mediated response. In contrast, pretreatment with heating or digestion with protease had no significant effect on supernatant-mediated response. These findings suggest that B16-BL6 cells may release nonpeptide substance(s) of <1,000 MW, resulting in significant cessation of lymphatic pump activity via production and release of endogenous NO and activation of mitochondrial ATP-sensitive K(+) channels.
Neural Face Rigging for Animating and Retargeting Facial Meshes in the Wild (2023)

We propose an end-to-end deep-learning approach for automatic rigging and retargeting of 3D models of human faces in the wild. Our approach, called Neural Face Rigging (NFR), holds three key properties: (i) NFR’s expression space maintains human-interpretable editing parameters for artistic controls; (ii) NFR is readily applicable to arbitrary facial meshes with different connectivity and expressions; (iii) NFR can encode and produce fine-grained details of complex expressions performed by arbitrary subjects. To the best of our knowledge, NFR is the first approach to provide realistic and controllable deformations of in-the-wild facial meshes, without the manual creation of blendshapes or correspondence. We design a deformation autoencoder and train it through a multi-dataset training scheme, which benefits from the unique advantages of two data sources: a linear 3DMM with interpretable control parameters as in FACS and 4D captures of real faces with fine-grained details. Through various experiments, we show NFR’s ability to automatically produce realistic and accurate facial deformations across a wide range of existing datasets and noisy facial scans in-the-wild, while providing artist-controlled, editable parameters.
A Zero Dead-Time, High Temporal Resolution, Time-of-Flight Particle Detector IC (1997)

This paper describes principles of the design of a CMOS time to digital converter integrated circuit, intended for time of flight spectrometry applications. The chip utilizes the differential delay line technique to achieve 150ps accuracy, and a novel read-out circuitry which allows the achievement of dead-time less operation.
Crystal and electronic structures of Bi4−xLaxTi3O12 ferroelectric materials (2001)

The crystal structures of Bi4Ti3O12 and Bi3.25La0.75Ti3O12 were refined by neutron powder diffraction. Large structural distortions were revealed, and ferroelectric polarizations along the a and c axes were calculated from the displacements of the constituent ions. In Bi3.25La0.75Ti3O12, La atoms substitute for Bi atoms in a perovskite-type unit only, and the substitution causes less distortion of the structure, resulting in smaller spontaneous polarization and lower ferroelectric Curie temperature. Electronic-structure calculations revealed that covalent interaction, which originates from the strong hybridization between Ti 3d and O 2p orbitals, plays an important role in the structural distortion and ferroelectricity of the materials. Changes in ceramic-sample density with sintering temperature give information concerning device fabrication temperature; that is, substituting La for Bi atoms appears to “increase” the synthesis temperature of the Bi4Ti3O12 and Bi3.25La0.75Ti3O12 systems.
WSJCAMO: a British English speech corpus for large vocabulary continuous speech recognition (2002)

A significant new speech corpus of British English has been recorded at Cambridge University. Derived from the Wall Street Journal text corpus, WSJCAMO constitutes one of the largest corpora of spoken British English currently in existence. It has been specifically designed for the construction and evaluation of speaker-independent speech recognition systems. The database consists of 140 speakers each speaking about 110 utterances. This paper describes the motivation for the corpus, the processes undertaken in its construction and the utilities needed as support tools. All utterance transcriptions have been verified and a phonetic dictionary has been developed to cover the training data and evaluation tasks. Two evaluation tasks have been defined using standard 5000 word bigram and 20000 word trigram language models. The paper concludes with comparative results on these tasks for British and American English.
Quality caesarean section in Burkina Faso: Beyond the technical procedure (2013)

info:eu-repo/semantics/published
Dietary fiber materials from corn. (1990)

Corn dietary fiber (CDF), a new source of dietary fiber, was prepared from corn pericarp by corn wet milling process. It has high dietary fiber content (85 % total dietary fiber) and may be used as fiber supplement in cookies, bread, soup, noodles, and other foods. This substance has significant effects : it shortens gastrointestinal transit time, stimulates bowel movement, and improves cholesterol metabolism. Recently, soluble corn dietary fiber (SCF), mainly?ghemicellulose B?hfraction, was prepared from corn pericarp. It is also high dietary fiber content (70-80 % total dietary fiber) and may be used in many foods. Because consumers are unlikely to eat enough vegetables or other fiberrich foods directly, natural fiber supplements of corn can play a role in achieving health benefits.
Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years (2016)

The extension of treatment with an adjuvant aromatase inhibitor to 10 years resulted in significantly higher rates of disease-free survival and a lower incidence of contralateral breast cancer than those with placebo, but the rate of overall survival was not higher with the aromatase inhibitor than with placebo. (Funded by the Canadian Cancer Society and others; ClinicalTrials.gov numbers, NCT00003140 and NCT00754845.).
Catalytic partial oxidation reforming of hydrocarbon fuels. (1998)

The polymer electrolyte fuel cell (PEFC) is the primary candidate as the power source for light-duty transportation systems. On-board conversion of fuels (reforming) to supply the required hydrogen has the potential to provide the driving range that is typical of today's automobiles. Petroleum-derived fuels, gasoline or some distillate similar to it, are attractive because of their existing production, distribution, and retailing infrastructure. The fuel may be either petroleum-derived or other alternative fuels such as methanol, ethanol, natural gas, etc. [1]. The ability to use a variety of fuels is also attractive for stationary distributed power generation [2], such as in buildings, or for portable power in remote locations. Argonne National Laboratory has developed a catalytic reactor based on partial oxidation reforming that is suitable for use in light-duty vehicles powered by fuel cells. The reactor has shown the ability to convert a wide variety of fuels to a hydrogen-rich gas at less than 800 C, temperatures that are several hundreds of degrees lower than alternative noncatalytic processes. The fuel may be methanol, ethanol, natural gas, or petroleum-derived fuels that are blends of various hydrocarbons such as paraffins, olefins, aromatics, etc., as in gasoline. This paper will discuss the results obtained from a bench-scale (3-kWe) reactor., where the reforming of gasoline and natural gas generated a product gas that contained 38% and 42% hydrogen on a dry basis at the reformer exit, respectively.