gebhart/patrepeval huggingface dataset:
HOUT-07. AN EVALUATION OF THE TREATMENT COURSE IN PATIENTS WITH GLIOBLASTOMA MULTIFORME (2018)

Glioblastoma multiforme (GBM) is a malignant brain tumor with a mean overall survival of 15 months using current treatment modalities. Previous studies have shown delays in treatment result in worse outcomes. Demographic and socioeconomic factors may have a role in treatment course variations. Therefore, the objective of this study was to investigate factors that influence time to treatment and effect overall survival in patients with GBM. Records from patients who were diagnosed with GBM and underwent surgery, radiotherapy, or chemotherapy at VCU Health between 2005 and 2015 were retrospectively reviewed. Linear regression was used to determine whether demographics, socioeconomic status, or presenting symptoms were associated with the time from first clinic visit to time of surgery, chemotherapy, radiotherapy first treatment, and time until all treatments were initiated. Then, cox proportional hazards regression assessed whether these five outcomes were independently related to overall survival. 126 patients were included in the study. Median survival was 10.6 months. None of the demographic factors or presenting symptoms were associated with time to treatment outcomes. Time to radiotherapy, chemotherapy, and all treatment initiation were significantly associated with overall survival after controlling for age, tumor location, and extent of resection (p< 0.01). A thirty-day decrease in time to radiotherapy, chemotherapy, and all treatment initiation were associated with increased mortality hazards of 1.05, 1.08, and 1.04, respectively. DISCUSSION: Our results indicated that demographics, socioeconomic factors, and presenting symptoms do not contribute to delays in treatment. Our study also revealed that, contrary to current literature, patients with shorter time to initiation of treatment had poorer outcomes. This could represent a specific population that presents later in their disease course and thus receives more aggressive treatment. Further investigation is therefore needed to elucidate the cause of this relationship and factors causing decreased survival in this population.
ChemInform Abstract: A Novel Photo‐Induced Substitution of Alkyl 2‐Cyano‐3‐quinolinecarboxylates. (1989)

Abstract The cyanoquinolinecarboxylates (I) are irradiated in the primary alcohols (II) or (V) to perform transesterification, followed by intramolecular substitution of the cyano group, yielding the fused lactones (III) or (VI) as the main products.
Fatigue Testing of Sheet Metals Subject to Uniaxial Tension-Compression (2001)

&lt;div class="htmlview paragraph"&gt;The paper describes the fabrication and testing of thin sheet metal uniaxial fatigue specimens that have been laminated to prevent buckling. When hot or cold rolled metal thicknesses are below 5 mm, the usual fatigue specimens, having a uniform gauge length of 7.5 mm or more, buckle in the short life region (∼10000 cycles) of strain-life testing. For thinner materials, non-standard specimen designs or anti-buckling guides have been used, but each of these solutions requires additional instrumentation. The results presented in this paper show that laminating multiple sheets of material together to increase the specimen's effective thickness raises the strain level for the onset of buckling of the standard uniaxial specimen. Constant and variable amplitude fatigue tests extending into the high-strain short-life region were performed. Fatigue life data for multiple layer specimens were in good agreement with those obtained for single layer specimens.&lt;/div&gt;
Design and Development of a Battery-Voltage-Driven Fuel Injector for Direct-Injection Gasoline Engines (2001)

&lt;div class="htmlview paragraph"&gt;The conventional fuel injector for direct-injection gasoline engines is driven by voltage step-up circuitry and current control circuitry. The voltage step-up circuitry boosts the battery voltage to near 100 volts. This conventional system is fairly large and a more compact system is preferable. We have developed a mass producible battery-voltage-driven fuel injector for direct-injection gasoline engines. The injector has a dual-coil structure that enables the injector to operate at the battery voltage, thus eliminating the need for either voltage step-up circuitry or current control circuitry. Deviation in battery voltage and changes in harness resistance are fully compensated through opening-coil energization-time control. In addition, with this control method, the injector can be used with a wide range of fuel pressures. In this paper, the design concept and the dynamic characteristics of the battery-voltage-driven fuel injector with a dual-coil structure and the opening-coil energized time control method is discussed in detail.&lt;/div&gt;
The Effect of Diclofenac Sodium on Renal Function (1989)

The effects of diclofenac sodium on the kidneys were studied during 4 1/2 hours in eight patients with normal renal function. Urinary output decreased within 10 min after the injection, and maximally by 80%. The renal plasma flow and the glomerular filtration rate initially diminished significantly, by 35%, but began to increase after only 2 hours. The dominant and persistent effect was reduction of free water clearance, with maximum fall from 5.9 to 0.08 ml/min after 2 1/2 hours. The long-lasting increased tubular reabsorption of water probably is important for the lowered intrapelvic pressure that is associated with good analgetic effect of diclofenac in ureteral colic.
A novel method to control microcapsule release behavior via photo‐crosslink polyurethane acrylate shells (2009)

Abstract A microcapsule system with polyurethane acrylate (PUA) shell is prepared by interfacial polymerization between acrylic polyurethane diisocyanate and water to achieve controlled release via UV irradiation. The size of the microcapsule is influenced by the concentration of protecting colloid and property of acrylic polyurethane diisocyanate. When concentration of polyvinyl alcohol (PVA) is 5% and molar ratio of TDI and acrylic ethoxylated pentaerythritol (acrylic PP50) rises to 1.50, average diameter of the microcapsule is only 3.3223 μm. Delivery of 4‐hydroxy‐4′‐isopropoxydiphenylsulfone (D‐8) encapsuled by PUA microcapsule in solution can be prevented effectively by 30‐min UV irradiation. Lightness (L*) is used to measure color changes of reaction between D‐8 in PUA microcapsule and 2‐anilino‐6‐dibutylamino‐3‐methylfluoran (ODB‐2) under thermal treatment. In dry state, irradiated PUA microcapsules are much harder to release D‐8 than those not irradiated. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Spectrum of mutations in the major human skeletal muscle chloride channel gene (CLCN1) leading to myotonia. (1995)

Autosomal dominant myotonia congenita and autosomal recessive generalized myotonia (GM) are genetic disorders characterized by the symptom of myotonia, which is based on an electrical instability of the muscle fiber membrane. Recently, these two phenotypes have been associated with mutations in the major muscle chloride channel gene CLCN1 on human chromosome 7q35. We have systematically screened the open reading frame of the CLCN1 gene for mutations by SSC analysis (SSCA) in a panel of 24 families and 17 single unrelated patients with human myotonia. By direct sequencing of aberrant SSCA conformers were revealed 15 different mutations in a total of 18 unrelated families and 13 single patients. Of these, 10 were novel (7 missense mutations, 2 mutations leading to frameshift, and 1 mutation predicted to affect normal splicing). In our overall sample of 94 GM chromosomes we were able to detect 48 (51%) mutant GM alleles. Three mutations (F413C), R894X, and a 14-bp deletion in exon 13) account for 32% of the GM chromosomes in the German population. Our finding that A437T is probably a polymorphism is in contrast to a recent report that the recessive phenotype GM is associated with this amino acid change. We also demonstrate that the R894X mutation may act as a recessive or a dominant mutation in the CLCN1 gene, probably depending on the genetic background. Functional expression of the R894X mutant in Xenopus oocytes revealed a large reduction, but not complete abolition, of chloride currents. Further, it had a weak dominant negative effect on wild-type currents in coexpression studies. Reduction of currents predicted for heterozygous carriers are close to the borderline value, which is sufficient to elicit myotonia.
Charge trapping and current–voltage bistability in InGaAs quantum wires (1996)

We report a clear evidence of bistability in the current–voltage characteristics of p-i-n heterostructures containing InGaAs V-shaped quantum wires. The observed phenomenon is explained in the framework of a single carrier transport model in which the quantum wires act like traps for the vertical current. The charge trapping phenomenon is indeed demonstrated by temperature-dependent photocurrent experiments.
Diamantoide. Chemie mit Nano‐Juwelen (2010)

Abstract Zukunft der Diamontoide. Obwohl die Klasse der Diamantoide schon seit Jahrzehnten bekannt ist, hat die Renaissance dieser molekularen Nanodiamanten erst vor kurzem begonnen. Im letzten Jahrhundert gab es bereits eine Vielzahl an Forschungsarbeiten auf dem Gebiet des kleinsten Diamantoiden, dem Adamantan. Viele dieser Arbeiten führten bereits zu Anwendungen auf unterschiedlichen wissenschaftlichen Gebieten. Allerdings wurden die großen Geschwister des Adamantans (bis auf Diamantan und Triamantan) bislang überhaupt noch nicht chemisch untersucht. Die selektive Modifikation der höheren Diamantoide stellt eine beeindruckende Herausforderung für die organische Chemie dar, bietet aber auch eine große Chance auf neuartige Materialien mit einzigartigen Eigenschaften. Während andere nanoskalige Diamantmaterialien oftmals Probleme mit Größenverteilungen und Reinheit aufweisen, besitzen die Diamantoide klar definierte Strukturen und hohe Reinheit. Nur sieben Jahre nach der ersten Isolation von höheren Diamantoiden aus Rohöl können wir festhalten, dass die Forschung auf diesem Gebiet mit sehr großen Schritten voranschreitet.
Retroviral-Mediated Gene Transduction (2003)

An obligatory part of the life cycle of retroviruses (Fig. 1) is a stable, chromosomally integrated form of the virus, known as the provirus. The existence of the proviral form of retroviruses has provided one of the main driving forces for their use as vectors for gene transfer because, in the instance of a replication-defective retrovirus vector, the proviral form is the end point of the transduction (infection) process of the target cell (Fig. 2). The use of (replication) defective retroviral vectors is therefore ideal where the goal is the stable genetic modification of the target cell. The term transduction is now used to describe the infection of a cell with such a replication-defective retrovirus. Although replication-competent retroviral vectors have also been made, these are not in general use and offer little to recommend them. In this chapter vector should be taken as referring specifically to replication-defective retroviral vectors.
An Efficient Probabilistic Approach for Graph Similarity Search (2018)

Graph similarity search is a common and fundamental operation in graph databases. One of the most popular graph similarity measures is the Graph Edit Distance (GED) mainly because of its broad applicability and high interpretability. Despite its prevalence, exact GED computation is proved to be NP-hard, which could result in unsatisfactory computational efficiency on large graphs. However, exactly accurate search results are usually unnecessary for real-world applications especially when the responsiveness is far more important than the accuracy. Thus, in this paper, we propose a novel probabilistic approach to efficiently estimate GED, which is further leveraged for the graph similarity search. Specifically, we first take branches as elementary structures in graphs, and introduce a novel graph similarity measure by comparing branches between graphs, i.e., Graph Branch Distance (GBD), which can be efficiently calculated in polynomial time. Then, we formulate the relationship between GED and GBD by considering branch variations as the result ascribed to graph edit operations, and model this process by probabilistic approaches. By applying our model, the GED between any two graphs can be efficiently estimated by their GBD, and these estimations are finally utilized in the graph similarity search. Extensive experiments show that our approach has better accuracy, efficiency and scalability than other comparable methods in the graph similarity search over real and synthetic data sets.
Realization of an Optical Filter Using POLICRYPS Holographic Gratings on Glass Waveguides (2008)

In this paper an optical filter is presented using a hybrid fabrication approach. The filter is made of a glass channel single mode optical waveguide covered by a POLICRYPS holographic grating. The fabrication process of the device is described and preliminary optical characterization is presented. The optical response of the filter is reported showing the capability of the device to filter wavelengths typically used in optical communication systems.
Connected Vehicle Diagnostics and Prognostics (2018)

This chapter describes a general framework, called an automatic field data analyzer (AFDA), as well as the related data analytic algorithms for connected vehicle diagnostics and prognostics (CVDP). The fault analysis results are provided to product development engineers with actionable design enhancement suggestions. A vehicle battery failure analysis on two years of data from 24 vehicles is performed to demonstrate the effectiveness of the proposed framework. An AFDA framework is developed that analyzes large volumes of on-road vehicle data, automatically identifies root causes of faults, and eventually provides actionable design enhancement suggestions. The framework and algorithms for the proposed AFDA have been applied to the data collected through a General Motors (GM) internal project. The chapter explains a high-level diagram of an AFDA. It consists of three parts, namely, the data collection subsystem, the information abstraction subsystem, and the root cause analysis subsystem.
Super-Twisting Differentiator-Based High Order Sliding Mode Voltage Control Design for DC-DC Buck Converters (2016)

This paper aims to focus on the smooth output of DC-DC buck converters in wireless power transfer systems under input perturbations and load disturbances using the high-order sliding mode controller (HOSM) and HOSM with super-twisting differentiator (HOSM + STD). The proposed control approach needs only measurement of converter output voltage. Theoretical analysis and design procedures, as well as the super-twisting differentiator of the proposed controller are presented in detail with the prescribed convergence law of high-order sliding modes. Comparisons of both simulation and experimental results among conventional proportional-integral (PI) control, traditional sliding mode control (SMC), HOSM and HOSM + STD under various test conditions such as steady state, input voltage perturbations and output load disturbances, are presented and discussed. The results demonstrate and validate the effectiveness and robustness of the proposed control method.
Gender Differences in Adrenal Cortex Steroid Production in SHR/N-Corpulent Rats (1994)

Gender differences in adrenal steroid hormone production and serum steroid hormone levels were compared in the spontaneous hypertensive/NIH-corpulent (cp) rat, which exhibits characteristics of both obesity and non-insulin-dependent diabetes mellitus. The study demonstrated that adrenal gland size correlated with adrenal production and serum levels of steroid hormones. Obese female SHR/N-cp rats were more steroidogenic than male SHR/N-cp rats; the size of their adrenal glands was twice that of the males (70 vs 33 mg). Body weights averaged 666 g for females and 829 g for males. Obese female rats had significantly higher serum concentrations of both corticosterone (827 vs 536 ng/ml) and aldosterone (675 vs 482 pg/ml) than obese male rats. As determined by in vitro assay, adrenal cortex production of corticosterone (2157 vs 1435 ng/30 min) and aldosterone (13.3 vs 9.5 ng/30 min) was significantly higher in obese female than in obese male rats. Adrenal production of testosterone in the in vitro assay was also significantly higher for obese female than male rats; however, adrenal estrogen production in obese rats did not differ significantly. The type of carbohydrate consumed (sucrose > starch) significantly affected serum levels of corticosterone, but not aldosterone, testosterone, or estrogen. Gender differences in adrenal steroid production and serum steroid levels suggest that hyperglycemia in obese SHR/N-cp rats may be, in part, the result of excess adrenal production of steroid hormones.
Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2) (2010)

The hSLC22A2 drug transporter is a critical determinant in the uptake and cytotoxicity of various platinum compounds, particularly oxaliplatin.
Static output feedback control for continuous-time TS descriptor models: Decoupling the Lyapunov function (2015)

The paper deals with static output feedback controller design for continuous-time Takagi-Sugeno descriptor models. Via the well-known Finsler's Lemma and the descriptor-redundancy approach a set of linear matrix inequalities are derived to solve this design problem. A numerical example shows the effectiveness of the proposed approaches.
Characterization of molybdenum oxide catalysts supported on anatase and rutile polymorphs of titania by low-temperature oxygen chemisorption (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of molybdenum oxide catalysts supported on anatase and rutile polymorphs of titania by low-temperature oxygen chemisorptionKomandur V. R. Chary, Veeramachaneni Vijayakumar, and Panja Kanta RaoCite this: Langmuir 1990, 6, 10, 1549–1550Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/la00100a004https://doi.org/10.1021/la00100a004research-articleACS PublicationsRequest reuse permissionsArticle Views144Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stable incidence and continued improvement in short term mortality of Staphylococcus aureus bacteraemia between 1995 and 2008 (2012)

Throughout a 14-year period the overall incidence of SAB remained stable while the overall short term prognosis continued to improve despite increased age and accumulation of comorbidity in the cohort. However, age and comorbidity were strong prognostic indicators for short term mortality.
Fin Performance Analysis for Microchannel Heat Exchangers Under Dry, Wet and Partial Wet Conditions (2014)

Numerical microchannel heat exchanger (MCHX) models are favored in recent research and development process due to their cost effectiveness as opposed to prototype development and testing. One of the challenges in using MCHX in the stationary heating, ventilating, air-conditioning and refrigeration (HVAC&R) applications is the evaporator design. A literature survey suggests that there lacks a unified air-to-surface heat transfer modeling approach for MCHX, especially under dehumidifying condition with tube-to-tube heat conduction. In this research, we present a fin heat transfer model under dry, wet and partial wet conditions for MCHX applications. Typically, there are two boundary conditions for the fins in MCHX. The adiabatic fin tip boundary condition is applied to the extended fins on top and bottom of the heat exchanger. The proposed model also accounts for tube-to-tube conduction wherein the surface temperatures of the two tubes bounding the fin are prescribed. The modeling approach is capable of locating the boundary between dry and wet surface if partial-wet condition appears. A finite volume approach is adopted in the proposed model where the fin is separated into segments in the air-flow direction. The model is verified against simulation results obtained using a commercially available Computational Fluid Dynamics (CFD) package. The changing air-side heat transfer coefficient along the air flow direction is calculated from CFD. These coefficients are then plugged into each segment in the fin analysis model. The prediction of two-dimensional temperature field along the fin surface using the proposed finite volume approach agrees very well with the CFD predictions. It is also expected that using the proposed wet-fin and partially-wet fin model, the latent load prediction in evaporators will be improved. The proposed model can serve as the foundation for further air-to-refrigerant heat transfer modeling in MCHX design and simulation tools.
A Review of Perovskites Solar Cell Stability (2019)

Abstract In this review, the factors influencing the power conversion efficiency (PCE) of perovskite solar cells (PSCs) is emphasized. The PCE of PSCs has remarkably increased from 3.8% to 23.7%, but on the other hand, poor stability is one of the main facets that creates a huge barrier in the commercialization of PSCs. Herein, a concise overview of the current efforts to enhance the stability of PSCs is provided; moreover, the degradation causes and mechanisms are summarized. The strategies to improve device stability are portrayed in terms of structural effects, a photoactive layer, hole‐ and electron‐transporting layers, electrode materials, and device encapsulation. Last but not least, the economic feasibility of PSCs is also vividly discussed.