gebhart/patrepeval huggingface dataset:
MD‐2 is involved in the stimulation of matrix metalloproteinase‐1 expression by interferon‐γ and high glucose in mononuclear cells – a potential role of MD‐2 in Toll‐like receptor 4‐independent signalling (2013)

We reported recently that treatment of diabetic apolipoprotein E-deficient mice with the Toll-like receptor 4 (TLR4) antagonist Rs-LPS, a lipopolysaccharide isolated from Rhodobacter sphaeroides, inhibited atherosclerosis. Since it is known that Rs-LPS antagonizes TLR4 by targeting TLR4 co-receptor MD-2, this finding indicates that MD-2 is a potential target for the treatment of atherosclerosis. In this study, we determined if MD-2 is involved in the gene expression regulated by signalling pathways independent of TLR4. Given that interferon-γ (IFNγ) and hyperglycaemia play key roles in atherosclerosis, we determined if MD-2 is involved in IFN-γ and high-glucose-regulated gene expression in mononuclear cells. Results showed that IFN-γ and high glucose synergistically stimulated matrix metalloproteinase 1 (MMP-1), a proteinase essential for vascular tissue remodelling and atherosclerosis, in U937 mononuclear cells, but Rs-LPS inhibited the MMP-1 stimulation. To provide more evidence for a role of MD-2 in IFN-γ-stimulated MMP-1, studies using antibodies and small interfering RNA demonstrated that MD-2 blockade or knockdown attenuated the effect of IFN-γ on MMP-1. Furthermore, studies using PCR arrays showed that MD-2 blockade had a similar effect as IFN-γ receptor blockade on the inhibition of IFN-γ-stimulated pro-inflammatory molecules. Although these findings indicate the involvement of MD-2 in IFN-γ signalling, we also observed that MD-2 was up-regulated by IFN-γ and high glucose. We found that MD-2 up-regulation by IFN-γ played an essential role in the synergistic effect of IFN-γ and LPS on MMP-1 expression. Taken together, these findings indicate that MD-2 is involved in IFN-γ signalling and IFN-γ-augmented MMP-1 up-regulation by LPS.
The constituents of licorice (Glycyrrhiza uralensis) differentially suppress nitric oxide production in interleukin-1β-treated hepatocytes (2015)

Licorice (Glycyrrhizae radix) is the roots and stolons of <i>Glycyrrhiza uralensis</i> Fischer or <i>Glycyrrhiza glabra</i> Linnaeus in the Japanese Pharmacopoeia. Glycyrrhizae radix has been widely used as a sweetener and a traditional medicine. A Glycyrrhizae radix extract contains many constituents and has antispasmodic, antitussive, anti-ulcer, and anti-inflammatory effects. However, reports comparing the anti-inflammatory effects of these constituents are very few. Here, we purified several constituents from the roots and stolons of <i>G. uralensis</i> and examined and compared their anti-inflammatory effects by monitoring the levels of the inflammatory mediator, nitric oxide (NO), in interleukin (IL)-1β-treated rat hepatocytes. From the <i>G. uralensis</i> extract, we purified the main constituent glycyrrhizin and the constituents that are characteristic of <i>G. uralensis</i> (chalcones and flavanones). These constituents suppressed NO production in IL-1β-treated rat hepatocytes, and isoliquiritigenin showed the greatest suppression activity. Isoliquiritigenin, isoliquiritin, and liquiritigenin significantly decreased both protein and mRNA for the inducible nitric oxide synthase. These constituents reduced the levels of mRNAs encoding tumor necrosis factor α and IL-6. In contrast, although glycyrrhizin is abundant, it showed a 100-fold lower potency in NO suppression. Therefore, both glycyrrhizin and the minor constituents (isoliquiritigenin, isoliquiritin, and liquiritigenin) may be responsible for the anti-inflammatory effects of <i>G. uralensis</i>. It is also implied that these constituents may have a therapeutic potential for inflammatory hepatic disorders.
Lipoblastoma en la infancia : informe de nueve casos y revisión de la literatura (2019)

Introduccion. El lipoblastoma es una neoplasia rara que contiene tejido adiposo
embrionario, se presenta con mayor frecuencia en la infancia. Se localiza de preferencia
en las extremidades. Se debe realizar diagnostico diferencial con lipoma y liposarcoma
mixoide.
El objetivo de este trabajo es conocer los aspectos clinicos. radiologicos y terapeuticos
para su deteccion temprana . tratamiento
Material y Metodos. Se revisaron los expedientes clinicos de los pacientes con diagnostico
histopatologico de lipob lastoma atendido en el Depanamento de Cirugia Oncologica del
Instituto Nacional de Pediatria del 1 de agosto de 1990 al 31 de julio de 1998. Las variables
estudiadas fueron edad al momento del diagnostico. sexo. manifestaciones clinicas. tamano
y localizacion del tumor. estudios radiolog icos. tipo de procedimiento quirurgico y estado
actual.
Resultados. Se atendieron nue\'e paciente . ocho (88.8%) con forma localizada y un caso
( 11.1 %) con fo rma di fu a· predomino el sexo femenino ( 1.25 :1) sobre el masculino. La
edad promedio fue de 53 mese . 66° o fueron menores de 38 meses. La principal
manifestacion clinica fue aumento de ,·olumen en nueve pacientes ( 1 00%): en cuatro casos
( 44.4%) se localizo en cabeza y cuello. en dos casos en extremidades, los tres restantes en
otros sitios anatomicos.
Las radiografias simples mostraron tmagene radiopacas en el tejido afectado, el
ultrasonido demostro imagene con eco mi;...-ios y la tomografia imagenes hipodensas se
realizo reseccion quirurgica completa en ocho pacientes (88 .8%) y reseccion parcial en un
caso ( 11 .1 %). en el que recurrio la enfermedad .
Conclusion: El lipoblastoma es una neoplasia benigna que en algunos casos tiene
componamiento agresi,·o. 66% fueron menores de tres anos y medio. Rara vez se presenta
despue de la primera decada de la ,·ida. Es importante identificarlo con Imagenes
radiologi cas. tratamiento debe ser la excis ion quirurgica completa
Purification and characterisation of endo-β-1,4-glucanase and laminarinase enzymes from the gecarcinid land crab Gecarcoidea natalis and the aquatic crayfish Cherax destructor (2008)

Laminarinase and endo-beta-1,4-glucanase were purified and characterised from the midgut gland of the herbivorous land crab Gecarcoidea natalis and the crayfish Cherax destructor. The laminarinase isolated from G. natalis was estimated to have a molecular mass of 41 kDa by SDS-PAGE and 71 kDa by gel filtration chromatography. A similar discrepancy was noted for C. destructor. Possible reasons for this are discussed. Laminarinase (EC 3.2.1.6) from G. natalis had a V(max) of 42.0 micromol reducing sugars produced min(-1) mg protein(-1), a K(m) of 0.126% (w/v) and an optimum pH range of 5.5-7, and hydrolysed mainly beta-1,3-glycosidic bonds. In addition to the hydrolysis of beta-1,3-glycosidic bonds, laminarinase (EC 3.2.1.39) from C. destructor was capable of significant hydrolysis of beta-1,4-glycosidic bonds. It had a V(max) of 19.6 mumol reducing sugars produced min(-1) mg protein(-1), a K(m) of 0.059% (w/v) and an optimum pH of 5.5. Laminarinase from both species produced glucose and other short oligomers from the hydrolysis of laminarin. Endo-beta-1,4-glucanase (EC 3.2.1.4) from G. natalis had a molecular mass of 52 kDa and an optimum pH of 4-7. It mainly hydrolysed beta-1,4-glycosidic bonds, but was also capable of significant hydrolysis of beta-1,3-glycosidic bonds. Two endo-beta-1,4-glucanases, termed 1 and 2, with respective molecular masses of 53+/-3 and 52 kDa, were purified from C. destructor. Endo-beta-1,4-glucanase 1 was only capable of hydrolysing beta-1,4-glycosidic bonds and had an optimum pH of 5.5. Endo-beta-1,4-glucanases from both species produced some glucose, cellobiose and other short oligomers from the hydrolysis of carboxymethyl cellulose.
Effectiveness and Safety of Pegfilgrastim in BEP Treatment for Patients with Germ Cell Tumor (2018)

Background: The effectiveness and safety of pegfilgrastim during bleomycin, etoposide and cisplatin (BEP) chemotherapy have not yet been investigated. Patients and Methods: Patients with germ cell tumors (GCTs) who received pegfilgrastim during BEP at the Kanazawa University Hospital between January 2014 and December 2016 were retrospectively analyzed. The frequency of adverse events and effectiveness in inhibiting neutropenia were compared between cycles using pegfilgrastim and those using filgrastim. Results: Pegfilgrastim and filgrastim were administered in 13 and 22 cycles, respectively. The absolute neutrophil count at the nadir was significantly lower in patients receiving pegfilgrastim than in those receiving filgrastim (p=0.003). The duration of grade 2-4 neutropenia in cycles using filgrastim was significantly longer than that in those pegfilgrastim (p=0.01). No significant differences in the incidence of febrile neutropenia and serious adverse events were observed. Conclusion: Pegfilgrastim can be safely and effectively administrated during BEP for patients with GCT.
Resonant diffraction losses in solid-state monomode lasers (2001)

The mechanism of resonant diffraction in solid-state lasers is theoretically investigated and experimentally isolated. It consists in a variation of the diffraction losses of a laser with the laser frequency, which is induced by a frequency-dependent saturation lenslike effect that occurs in the active medium. It is shown that this mechanism can lead to peculiar variations in the laser slope efficiency. The diffracted-light spectroscopy technique permits these variations to be connected with the calculated saturation lenslike effects in a diode end-pumped Er,Yb:glass laser.
Short papers in pharmaceutical analysis (1993)

C. J. Goodwin, K. D. Altria, S. D. Filbey, A. Scott, P. R. Vojvodic, N. H. Anderson, B. J. Clark, A. E. Bretnall, T. Cowen, R. Howling, G. Hutchinson, K. M. Sereda, T. C. Hardman, M. R. Dilloway, A. F. Lant, I. D. Smith, P. D. Blackler and D. G. Waters, Anal. Proc., 1993, 30, 361 DOI: 10.1039/AP9933000361
Emerging two-dimensional monoelemental materials (Xenes) for biomedical applications (2019)

The emergence of novel two-dimensional (2D) monoelemental materials (Xenes) has shown remarkable potential for their applications in different fields of technology, as well as addressing new discoveries in fundamental science. Xenes (e.g., borophene, silicene, germanene, stanene, phosphorene, arsenene, antimonene, bismuthene, and tellurene) are of particular interest because they are the most chemically tractable materials for synthetic exploration. Owing to their excellent physical, chemical, electronic and optical properties, Xenes have been regarded as promising agents for biosensors, bioimaging, therapeutic delivery, and theranostics, as well as in several other new bio-applications. In this tutorial review, we summarize their general properties including the classification of Xenes according to their bulk properties. The synthetic and modification methods of Xenes are also presented. Furthermore, the representative Xene nanoplatforms for various biomedical applications are highlighted. Finally, research progress, challenges, and perspectives for the future development of Xenes in biomedicines are discussed.
Cellular Origin of the Chemokinetic Inhibitor of Polymorphononuclear Leucocytes Found in Sera from Patients with Chronic Lymphocytic Leukaemia (1983)

In a previous study, we demonstrated the existence in serum from patients with chronic lymphocytic leukaemia (CLL) of a cell-directed, heat-labile chemokinetic inhibitor of polymorphonuclear leucocytes (PMN). The aim of this investigation was to study the cellular origin of this inhibitor. Supernatants from short term cultured lymphocytes from 3 healthy persons and 5 patients with CLL, and from 16 different established human non-haematopoietic and haematopoietic cell lines were analyzed. Only the leukaemic B-lymphocytes from the CLL patients produced the inhibitor. The presence of the inhibitor was also demonstrated in supernatants from the fresh CLL cells from one CLL patient and a leukaemic cell line established from these cells using Epstein-Barr virus as the immortalizing agent. A lymphoblastoid cell line derived from the normal B-cells of the same CLL patient did not produce the chemokinetic inhibitor. We therefore conclude that the cellular origin of the heat-labile, cell-directed chemokinetic inhibitor of PMN migration is the CLL cell.
Asymmetric Student-Teacher Networks for Industrial Anomaly Detection (2022)

Industrial defect detection is commonly addressed with anomaly detection (AD) methods where no or only incomplete data of potentially occurring defects is available. This work discovers previously unknown problems of student-teacher approaches for AD and proposes a solution, where two neural networks are trained to produce the same output for the defect-free training examples. The core assumption of student-teacher networks is that the distance between the outputs of both networks is larger for anomalies since they are absent in training. However, previous methods suffer from the similarity of student and teacher architecture, such that the distance is undesirably small for anomalies. For this reason, we propose asymmetric student-teacher networks (AST). We train a normalizing flow for density estimation as a teacher and a conventional feed-forward network as a student to trigger large distances for anomalies: The bijectivity of the normalizing flow enforces a divergence of teacher outputs for anomalies compared to normal data. Outside the training distribution the student cannot imitate this divergence due to its fundamentally different architecture. Our AST network compensates for wrongly estimated likelihoods by a normalizing flow, which was alternatively used for anomaly detection in previous work. We show that our method produces state-of-the-art results on the two currently most relevant defect detection datasets MVTec AD and MVTec 3D-AD regarding image-level anomaly detection on RGB and 3D data.
Interpenetrating polymer network based hydrogel: A smart approach for corroborating wound healing of various capacity (2023)

Abstract Hemorrhage of high intensity usually leads to severe mortality accidents, disaster, and warfare. The concomitant wound thereby induces immense psychological as well as physical trauma to the patients. Hence, a faster hemostasis with smart wound healing approaches are highly essential to deal such critical/life threatening situations. The traditional approaches such as implementation of gauze and bandages are found to be having limited scope for controlling hemorrhage, because of non‐biodegradability, high susceptibility towards infection, unsuitability for irregular wound and ineffective towards wound healing. By virtue of the merits revealed by remodeling interpenetrating polymer network (IPN) based hydrogels (biocompatibility, high porosity, tunability, biomimetic and better retention, and proliferative wound healing tendency), have drawn a rigorous attention to out play their ancestors. This review includes the involvement of numerous synthetic routes, types and physicochemical properties of IPN based hydrogels loaded with diverse therapeutic agents towards wound repair/healing. Moreover, some of the recent patents have been portrayed in the manuscript, dignifying the potentiality of fascinating IPN hydrogels towards effective wound healing. More research is required to engineer multifaceted IPN hydrogels to attain huge potential against the challenges and future perspectives in wound healing.
Incentive schemes in the financial services sector (2008)

Purpose The purpose of this paper is to show that new technologies have significantly changed the way that customers interact with their bank. Whilst a trip down to the local branch was mandatory in the past for a customer to do their banking, all that is required now in many situations is simply to send a text message or log on to the internet. However, the idea of exploiting customer competency with new technologies to create new distribution channels has become a double‐edged sword. Although the distance between the bank and its customer is shortened in that direct contact can be established within a matter of seconds with these new technologies, the impact on the customer's perceived relationship with the brand remains an issue of strategic importance that needs to be evaluated. In order to exploit the advantages of technology, a full understanding of the factors and processes involved in the customer‐brand relationship associated with use of self‐service banking channels is necessary. Design/methodology/approach The methodology is an empirical study using bank customers as participants, which was conducted to examine the impact of salient relationship norms on customers' perceptions of their relationship with their bank. Findings Based on the experiment data, the paper establishes the relevance of the concepts of communal and exchange relationship norms in the study of customer‐brand relationships in a business context. Originality/value The implications from the findings provide insights into the importance of relationship theory in explaining customers' perceived relationship with brands, specifically that of their bank.
Topoisomerase II Site-directed Alkylation of DNA by Psorospermin and Its Effect on Topoisomerase II-mediated DNA Cleavage (1998)

Psorospermin, a plant-derived antitumor agent, has been shown to selectively alkylate a guanine at the topoisomerase II cleavage site to trap the topoisomerase II-DNA cleaved complex. The results of this study provide further important insight into the mechanism of the topoisomerase II site-directed alkylation of DNA by psorospermin and its subsequent effects on the topoisomerase II-induced DNA cleavage. First, we demonstrate that the topoisomerase II-induced alkylation of DNA by psorospermin occurs at a time preceding the topoisomerase II-mediated strand cleavage event, because it occurs in the absence of Mg2+. We confirm that the alkylation of DNA by psorospermin takes place at N-7 of guanine in the presence of topoisomerase II, because substitution of the target guanine by 7-deazaguanine prevents alkylation. Because the stimulation of the topoisomerase II-induced DNA cleavage by psorospermin can be slowly reversed by the addition of excess salt, this indicates that alkylation of DNA by psorospermin traps a reversible topoisomerase II-DNA complex. Both the DNA alkylation by psorospermin in the presence of topoisomerase II and the enzyme-mediated DNA cleavage elevated by psorospermin are more enhanced at acidic pH values, in accordance with the increased stability of the topoisomerase II-DNA complex at acidic pH values. Finally, our results suggest that it is the psorospermin-DNA adducts, not the abasic sites resulting from depurination, that are responsible for the stimulation of the topoisomerase II-mediated cleavage. Because the precise location of the psorospermin within the topoisomerase II cleavage site is known, together with the covalent DNA linkage chemistry and the conformation of the psorospermin-DNA adduct, this structural insight provides an excellent opportunity for the design and synthesis of new, more effective topoisomerase II poisons.
Mass Spectrometry (2004)

This chapter contains sections titled: Introduction Fundamentals of Mass Spectrometry Fundamentals of Protein and Peptide Mass Spectrometry Mass Spectrometry for Protein and Proteome Characterization Summary
Fast time-of-flight MR angiography with improved background suppression. (1991)

A new technique for improving contrast in time-of-flight magnetic resonance (MR) angiography is described. A selective 180 degrees radio-frequency pulse was applied before data acquisition to suppress the signal intensity of stationary tissues. Vascular images were obtained in 1 second or less by using a single-shot, rapid gradient-echo sequence in conjunction with a very short echo time to minimize flow-related dephasing. Alternatively, the data acquisition could be divided into several segments that were combined to create an image. Because of the short imaging times, abdominal single-shot images were relatively insensitive to motion. The major drawback was decreased spatial resolution and limited signal-to-noise ratio. Spatial resolution of segmented flow images was comparable with that of standard gradient-echo images, but there was a marked reduction in the signal intensity of stationary tissues. For high-resolution MR angiography, the effective background suppression obtained by means of the segmented approach can improve the quality and reliability of images created by the maximum intensity projection algorithm.
A perspective of the generator testing and model validation program in WSCC (1999)

Western Systems Coordinating Council's (WSCC) Generator Testing Program (GTP) was developed and initiated as a direct result of the severe electric system disturbances experienced throughout the Western Interconnection in July and August 1996. The tests recommended by WSCC include static tests to verify the reactive MVAr limits of operation of generating units and synchronous condensers, and dynamic tests of synchronous machines for model validation of generators, excitation systems, power system stabilizers, and turbine-governors. The recommendation to test generating units was made recognizing that it would entail costs, potential risks, and significant effort. The recommendation for dynamic model validation testing of synchronous generators and static tests to verify the reactive MVAr limits of generators was endorsed at the highest level by the WSCC Board of Trustees and by the North American Electric Reliability Council (NERC). WSCC's testing initiative is applicable to all units, 10 MW or larger, regardless of ownership, class of market participant, or interconnection voltage level.
Carbene complexes. Part I. Electron-rich olefins as a source of carbene complexes of platinum(II) and palladium(II); and some experiments with (CF3)2CN2 (1973)

The reactions of electron-rich olefins with di-µ-chloro-dichlorobis(phosphine)diplatinum(II)(and bromo-, arsine-, and PdII analogues) have been investigated. In general, the product is the trans-PtII or PdII carbene complex, or the cis-isomer, or a mixture of these compounds, depending on the reagents, solvent, and reaction conditions. The compounds are stable, crystalline, and monomeric. Bis(trifluoromethyl)diazomethane reacts with (i) di-µ-chloro-dichlorobis(triethylphosphine)diplatinum(II) to give the product of insertion only into the terminal Pt–Cl bonds, and (II) tris(triphenylphosphine)platinum(0) to furnish the adduct Pt[(CF3)2CN2·(CF3)2C](PPh3)2. Structures and mechanisms are discussed.
Courtship in the Ring-Necked Duck (1963)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Lipid-Coated Mesoporous Silica Nanoparticle Technology for Antiviral Delivery to Inhibit Encephalitic Alphavirus Infection. (2020)

Abstract not provided.
Effect of Simazine on Nitrate Reductase Activity in Corn (1967)

The nutritional and environmental parameters required for eliciting increases in the nitrogen content and growth of corn (Zea mays L.) by non-toxic levels of simazine have been established. Corn seedlings with the endosperm removed 10 days after germination, proved to be a suitable test species. The addition of simazine to the root-zone area of corn plants grown under both sub-optimal temperatures and low nitrate levels, increased the nitrogen content and dry weight of the plants by 20 to 25%. This increase was found to be associated with an effect on nitrate reductase.
Plant morphological characteristics for year-round production and its fruit quality in response to different light wavelengths in blueberry (2018)

ISHS XIII International Symposium on Plant Bioregulators in Fruit Production Plant morphological characteristics for year-round production and its fruit quality in response to different light wavelengths in blueberry