gebhart/patrepeval huggingface dataset:
A dynamic energy recycling logic family for ultra-low-power gigascale integration (GSI) (1996)

A novel quasi-adiabatic, precharge-evaluate logic family, Dynamic Adiabatic MOS (DAMOS), is proposed. Wave-pipelined DAMOS inverter chain datapaths in a 0.25 /spl mu/m, 2.5 V CMOS device technology are shown to successfully recycle 73% and 89% of the energy available from the power-clock in high-performance (200 MHz) and fixed-throughput (10 MHz) applications, respectively. DAMOS offers significantly smaller energy dissipation and device count per gate compared to previously reported dynamic quasi-adiabatic (but irreversible) logic families. Computational energy and power of a wave-pipelined DAMOS inverter chain (excluding dissipations in the power-clock generator) are 83% to 93% smaller than that consumed by its conventional Domino CMOS counterpart (excluding dissipations in the clock drivers) at identical operational throughputs. In addition, DAMOS provides one to three orders of magnitude reduction in peak power compared to Domino logic, indicating significant relaxation of electrical stress in both devices and interconnections. Novel high-efficiency power-clock generation techniques must be pursued to fully exploit the large computational energy efficiency of quasi-adiabatic logic in general and of DAMOS in particular.
Perforation of the femoral shaft during total hip replacement. (1980)

Perforation of the femoral shaft by the prosthetic stem as a complication of total hip replacement is not well described in the literature. We studied twelve patients with this complication in order to define the predisposing factors, optimum management, and long-term outcome. Each patient was found to have one or more of the following factors: female sex, osteoporosis, previous fracture, or previous surgery. Once the complication was recognized, management consisted of protected weight-bearing for six weeks. All but two of the patients were asymptomatic after an average follow-up of five years. Judging from the long-term roetgenographic follow-up, penetration of the femoral shaft does not appear to seriously compromise the fixation of the femoral component.
Gene Expression Signatures of Energetic Acclimatisation in the Reef Building Coral Acropora millepora (2013)

Coral host gene expression adjusts rapidly upon change in nutritional conditions, and therefore can serve as an early signature of imminent coral stress. Consistent gene expression differences between populations indicate that corals acclimatize and/or adapt to local environments. Our results set the stage for analysis of these processes in natural coral populations, to better understand the responses of coral communities to global climate change and to develop more efficient management strategies.
Multiband product rule and consonant identification (2009)

The multiband product rule, also known as band-independence, is a basic assumption of articulation index and its extension, the speech intelligibility index. Previously Fletcher showed its validity for a balanced mix of 20% consonant-vowel (CV), 20% vowel-consonant (VC), and 60% consonant-vowel-consonant (CVC) sounds. This study repeats Miller and Nicely's version of the hi-/lo-pass experiment with minor changes to study band-independence for the 16 Miller-Nicely consonants. The cut-off frequencies are chosen such that the basilar membrane is evenly divided into 12 segments from 250 to 8000 Hz with the high-pass and low-pass filters sharing the same six cut-off frequencies in the middle. Results show that the multiband product rule is statistically valid for consonants on average. It also applies to subgroups of consonants, such as stops and fricatives, which are characterized by a flat distribution of speech cues along the frequency. It fails for individual consonants.
Enzymes degraded under high light maintain proteostasis by transcriptional regulation in Arabidopsis (2022)

Photoinhibitory high light stress in Arabidopsis leads to increases in markers of protein degradation and transcriptional up-regulation of proteases and proteolytic machinery, but proteostasis is largely maintained. We find significant increases in the in vivo degradation rate for specific molecular chaperones, nitrate reductase, glyceraldehyde-3 phosphate dehydrogenase, and phosphoglycerate kinase and other plastid, mitochondrial, peroxisomal, and cytosolic enzymes involved in redox shuttles. Coupled analysis of protein degradation rates, mRNA levels, and protein abundance reveal that 57% of the nuclear-encoded enzymes with higher degradation rates also had high light–induced transcriptional responses to maintain proteostasis. In contrast, plastid-encoded proteins with enhanced degradation rates showed decreased transcript abundances and must maintain protein abundance by other processes. This analysis reveals a light-induced transcriptional program for nuclear-encoded genes, beyond the regulation of the photosystem II (PSII) D1 subunit and the function of PSII, to replace key protein degradation targets in plants and ensure proteostasis under high light stress.
Morphology of the bentonite and kaolin-induced rat-paw oedemas. (1982)

The bentonite and kaolin oedemas were simultaneously induced in the rat hind paws and their courses and morphological patterns were observed under the conditions of the same biological background. Gross examination has confirmed the former experience that the kaolin oedema has a more pronounced acute phase (maximum after five to seven hours) followed by subsequent spontaneous regression of the oedema, while the bentonite oedema has its acute phase less pronounced, attains its peak only on the second day, maintaining this same size over several weeks without substantial changes. The courses of the two oedemas were in correlation with the results of histological evaluation (oedematous exudation, polymorphonuclear and mononuclear infiltration and the phagocytic activity of the latter). Resorption of kaolin in the newly-developed non-specific granulation tissue was much faster than that of bentonite (after about three weeks, while bentonite was not resorbed even after six weeks). Further, pharmacological and histological examination was performed of the effects on the bentonite oedema of sodium salicylate and Prednisone during the first 24 hours. Both substances suppressed the oedema, sodium salicylate delayed both polymorphonuclear and mononuclear infiltration, Prednisone delayed only mononuclear infiltration. The presence of mononuclear population was confirmed also by means of the positive activity of non-specific esterase and the negative activity of alkaline phosphatase. The bentonite rat-paw oedema has thus been proved to be a suitable model of inflammatory reaction for testing anti-inflammatory drugs not only in short-term (acute) tests, but also in long-term ones, where it yields a uniform picture of non-specific foreign-body low-turnover granuloma.
Active Region Cascading for Improved Performance in InAs–GaSb Superlattice LEDs (2008)

Cascading of active regions in InAs-GaSb superlattice light-emitting diodes (LEDs) grown by molecular beam epitaxy is demonstrated as an effective means of increasing optical emission. Devices were fabricated into 120 x 120 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> mesas to demonstrate suitability for high resolution projection systems. Devices with 1, 4, 8, and 16 stages were designed for midwave infrared emission at 3.8 mum operating at 77 K, and quasi-continuous-wave output powers in excess of 900 muW from a 16-stage LED have been demonstrated. External quantum efficiency is shown to improve substantially with cascading, approaching 10% for a 16-stage device.
Proteomics of Mouse BRCA1-deficient Mammary Tumors Identifies DNA Repair Proteins with Potential Diagnostic and Prognostic Value in Human Breast Cancer (2012)

Breast cancer 1, early onset (BRCA1) hereditary breast cancer, a type of cancer with defects in the homology-directed DNA repair pathway, would benefit from the identification of proteins for diagnosis, which might also be of potential use as screening, prognostic, or predictive markers. Sporadic breast cancers with defects in the BRCA1 pathway might also be diagnosed. We employed proteomics based on one-dimensional gel electrophoresis in combination with nano-LC-MS/MS and spectral counting to compare the protein profiles of mammary tumor tissues of genetic mouse models either deficient or proficient in BRCA1. We identified a total of 3,545 proteins, of which 801 were significantly differentially regulated between the BRCA1-deficient and -proficient breast tumors. Pathway and protein complex analysis identified DNA repair and related functions as the major processes associated with the up-regulated proteins in the BRCA1-deficient tumors. In addition, by selecting highly connected nodes, we identified a BRCA1 deficiency signature of 45 proteins that enriches for homology-directed DNA repair deficiency in human gene expression breast cancer data sets. This signature also exhibits prognostic power across multiple data sets, with optimal performance in a data set enriched in tumors deficient in homology-directed DNA repair. In conclusion, by comparing mouse proteomes from BRCA1-proficient and -deficient mammary tumors, we were able to identify several markers associated with BRCA1 deficiency and a prognostic signature for human breast cancer deficient in homology-directed DNA repair.
Local Wetting Modification on Carnauba Wax‐Coated Hierarchical Surfaces by Infrared Laser Treatment (2013)

This chapter contains sections titled: Introduction Experimental Results and Discussion Conclusions
Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo (1997)

Human immunodeficiency virus type 1 (HIV-1) accessory genes including nef, vif, and vpr are important factors that determine the replication and pathogenesis of HIV-1. The state of activation is also important for the replication of HIV-1. We evaluated the properties of nef-, vif-, and vpr-minus macrophage-tropic HIV-1(JR) CSF in primary CD4+ Th1- or Th2-like cell cultures which had been activated through CD3 molecules in the presence of interleukin-2 (IL-2) and IL-12 (Th1-like culture) or IL-4 (Th2-like culture), respectively. In activated Th1- or Th2-like cultures, replication of nef-minus HIV-1(JR-CSF) was markedly lower than that of wild-type HIV-1. Subsequent analysis by site-directed mutagenesis showed that (i) the presence of an acidic amino acid-rich domain (amino acid residues 72 to 75) in the Nef protein was critical for the enhancement of viral DNA synthesis, resulting in increased virus growth rate, and (ii) prolines that form part of Src homology 3 binding domain were not essential for viral replication. We also confirmed the importance of sites by using an HIV-1-infected animal model, the hu-PBL-SCID mouse system, representing HIV-1 replication and pathogenesis in activated CD4+ T cells in vivo. These results indicate that Nef accelerates viral replication in activated CD4+ T cells.
Thermocrinis minervae sp. nov., a hydrogen- and sulfur-oxidizing, thermophilic member of the Aquificales from a Costa Rican terrestrial hot spring (2009)

A thermophilic bacterium, designated strain CR11(T), was isolated from a filamentous sample collected from a terrestrial hot spring on the south-western foothills of the Rincón volcano in Costa Rica. The Gram-negative cells are approximately 2.4-3.9 microm long and 0.5-0.6 microm wide and are motile rods with polar flagella. Strain CR11(T) grows between 65 and 85 degrees C (optimum 75 degrees C, doubling time 4.5 h) and between pH 4.8 and 7.8 (optimum pH 5.9-6.5). The isolate grows chemolithotrophically with S(0), S(2)O(2)(3)(-) or H(2) as the electron donor and with O(2) (up to 16 %, v/v) as the sole electron acceptor. The isolate can grow on mannose, glucose, maltose, succinate, peptone, Casamino acids, starch, citrate and yeast extract in the presence of oxygen (4 %) and S(0). Growth occurs only at NaCl concentrations below 0.4 % (w/v). The G+C content of strain CR11(T) is 40.3 mol%. Phylogenetic analysis of the 16S rRNA gene sequence places the strain as a close relative of Thermocrinis ruber OC 1/4(T) (95.7 % sequence similarity). Based on phylogenetic and physiological characteristics, we propose the name Thermocrinis minervae sp. nov., with CR11(T) (=DSM 19557(T) =ATCC BAA-1533(T)) as the type strain.
Prediction of mechanical properties of short kevlar fiber‐nylon‐6,6 composites (1994)

Abstract Injection molded short Kevlar (DuPont) fiber/nylon‐6,6 composites have been studied. Fiber length and length distribution were measured as a function of processing variables. Critical fiber length was measured by an embedded single‐fiber method. Tensile modulus of the molded composites was predicted by an adapted classical lamination analogy. Fiber and matrix orientation factors, derived from X‐ray diffraction, were introduced to modify Kelly Tyson equation to estimate the composite tensile strength. It has been found that fiber length is dramatically shortened by the injection molding process, and is affected by processing conditions. Predictions gave reasonable agreement with data for tensile modulus and strength.
Clinical study of cardiac arrhythmias using a 24-hour continuous electrocardiographic recorder (5th report) - Antiarrhythmic action of coenzyme Q10 in diabetics. (1983)

An investigation was undertaken to evaluate the antiarrhythmic effect of CoQ10 on VPBs using the Holter ECG, in 27 patients with no clinical findings of organic cardiopathies. As a result, the effect of CoQ10 on VPBs was considered beneficial in 6 (22%) of 27 cases, consisting of 1 patient with hypertension and 5 patients with DM. Even in the remaining 2 patients with DM, the frequency of VPBs was reduced by 50% or more during treatment with CoQ10. The mean reduction of VPBs frequency in the 5 responders plus these 2 patients with DM was 85.7%. These findings suggest that CoQ10 exhibits an effective antiarrhythmic action not merely on organic heart disease but also on VPBs supervening on DM.
[Effect of integrative Chinese and western medicine on T-lymphocyte subsets in treating patients with severe acute respiratory syndrome]. (2004)

Glycocorticosteroid and Chinese herbal medicine treatments could promote the recovery of T-lymphocyte profile, rationally use of them is the effective therapeutic method.
Environmental Hotspot Identification in Limited Time with a UAV Equipped\n with a Downward-Facing Camera (2019)

Our work is motivated by environmental monitoring tasks, where finding the\nglobal maxima (i.e., hotspot) of a spatially varying field is crucial. We\ninvestigate the problem of identifying the hotspot for fields that can be\nsensed using an Unmanned Aerial Vehicle (UAV) equipped with a downward-facing\ncamera. The UAV has a limited time budget which it can use for learning the\nunknown field and identifying the hotspot. Our contribution is to show how this\nproblem can be formulated as a novel multi-fidelity variant of the Gaussian\nProcess (GP) multi-armed bandit problem. The novelty is two-fold: (i) unlike\nstandard multi-armed bandit settings, the rewards of the arms are correlated\nwith each other; and (ii) unlike standard GP regression, the measurements in\nour problem are images (i.e., vector measurements) whose quality depends on the\naltitude of the UAV. We present a strategy for finding the sequence of UAV\nsensing locations and empirically compare it with several baselines.\nExperimental results using images gathered onboard a UAV are also presented and\nthe scalability of the proposed methodology is assessed in a large-scale\nsimulated environment in Gazebo.\n
Gouy shift and temporal reshaping of focused single-cycle electromagnetic pulses:?errata (1998)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Simin Feng, Herbert G. Winful, and Robert W. Hellwarth, "Gouy shift and temporal reshaping of focused single-cycle electromagnetic pulses:?errata," Opt. Lett. 23, 1141-1141 (1998) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Targeted Somatic Mutagenesis in the Mouse Epidermis (2004)

The efficient introduction of somatic mutations in a given gene at a given time and in specific cell types of the skin will greatly facilitate the studies of a number of genes expressed in the skin and the production of animal models for skin diseases. We describe here strategies and techniques to create spatiotemporally controlled somatic mutations of target genes in the skin using a conditional Cre/LoxP system. They are based on cell-specific expression of the chimeric Cre recombinase Cre-ERT2, whose activity is induced by antiestrogens such as Tamoxifen (Tam), and which is obtained by fusing the Cre recombinase with a mutated ligand binding domain of the human estrogen receptor ERalpha. As an example, we present ablation of the retinoid receptor RXRalpha in epidermal basal keratinocytes of adult mice.
A kinetic study of the reactions of tert-butoxyl with alkenes: hydrogen abstraction vs. addition (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA kinetic study of the reactions of tert-butoxyl with alkenes: hydrogen abstraction vs. additionP. C. Wong, D. Griller, and J. C. ScaianoCite this: J. Am. Chem. Soc. 1982, 104, 19, 5106–5108Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/ja00383a018https://doi.org/10.1021/ja00383a018research-articleACS PublicationsRequest reuse permissionsArticle Views264Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Metabarcoding data reveal vertical multitaxa variation in topsoil communities during the colonization of deglaciated forelands (2022)

Ice-free areas are expanding worldwide due to dramatic glacier shrinkage and are undergoing rapid colonization by multiple lifeforms, thus representing key environments to study ecosystem development. It has been proposed that the colonization dynamics of deglaciated terrains is different between surface and deep soils but that the heterogeneity between communities inhabiting surface and deep soils decreases through time. Nevertheless, tests of this hypothesis remain scarce, and it is unclear whether patterns are consistent among different taxonomic groups. Here, we used environmental DNA metabarcoding to test whether community diversity and composition of six groups (Eukaryota, Bacteria, Mycota, Collembola, Insecta, and Oligochaeta) differ between the surface (0-5 cm) and deeper (7.5-20 cm) soil at different stages of development and across five Alpine glaciers. Taxonomic diversity increased with time since glacier retreat and with soil evolution. The pattern was consistent across groups and soil depths. For Eukaryota and Mycota, alpha-diversity was highest at the surface. Time since glacier retreat explained more variation of community composition than depth. Beta-diversity between surface and deep layers decreased with time since glacier retreat, supporting the hypothesis that the first 20 cm of soil tends to homogenize through time. Several molecular operational taxonomic units of bacteria and fungi were significant indicators of specific depths and/or soil development stages, confirming the strong functional variation of microbial communities through time and depth. The complexity of community patterns highlights the importance of integrating information from multiple taxonomic groups to unravel community variation in response to ongoing global changes.
Comparison of Media Proteins from Ovariectomized Rat Uteri Following Estrogen Treatment (1985)

Ovariectomized rats were treated with estradiol for 3 days after which their uteri were incubated in vitro and radioactive media proteins were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Media were also chromatographed on G-25 Sephadex Blue Sepharose columns to isolate subsets of proteins. The results demonstrate that two proteins are consistently increased following estrogen treatment. These proteins have molecular weights of 104,000 and 65,000. Neither protein binds to Blue Sepharose to a great extent. The use of the protein synthesis inhibitors, emetine and actinomycin D, demonstrates that the proteins are synthesized de novo. These two proteins may serve as markers for genomic response to estradiol in the rat uterus.
The role of indigenous microflora in the development of murine intestinal fucosyl‐ and sialyltransferases (2002)

Most enteric bacteria use intestinal brushborder glycoconjugates as their target host cell receptors. It has been postulated that resident microbes regulate specific glycosyltransferases that are responsible for synthesizing brushborder glycoconjugates. To investigate this hypothesis, we measured glycosyltransferase enzyme activities in intestine from different regions of maturing conventional (CONV), germ-free (GF), and ex-germ-free (XGF) mice and compared them to general enzyme markers of gut development, for example, disaccharidases. High alpha2,3/6-Sialyltransferase (ST) activity and low alpha1,2-fucosyltransferase (FT) activities were detected from duodenum to colon in suckling CONV mice, but the relative levels of these activities reversed during the third postnatal wk, rapidly reaching adult levels by the fourth wk. These age-related enzyme changes were significantly attenuated in GF mice, maintaining an immature pattern well past 3 wk. Introduction of gut microflora in GF mice rapidly initiated maturation of glycosyltransferase activity but had no significant affect on developmental programming of dissacharidases. Therefore, in mice, intestinal glycosyltransferase activities are under tissue and developmental control and microflora play a major role in their specific ontogeny but not in overall development. These findings may help explain the regional specificity of commensal bacteria and of enteric pathogens and may also relate age-related changes in microflora to susceptibility to enteropathogens.
Differential Expression Levels of MRP1, MRP4, and MRP5 in Response to Human Immunodeficiency Virus Infection in Human Macrophages (2004)

Multidrug resistance proteins (MRPs) have been reported to be involved in the efflux of some anti-human immunodeficiency virus (HIV) drugs. We show here that MRP1, MRP4, and MRP5 are expressed at the mRNA level in human monocyte-derived macrophages. HIV infection caused increased transcription of these MRPs; however, temporal differences in stimulation are reported.