gebhart/patrepeval huggingface dataset:
HEMORHEOLOGICAL PROPERTIES OF THE 5-HT2A-ANTAGONIST OF THE 2-METHOXYPHENYL-IMIDAZOBENZIMIDAZOLE DERIVATIVE OF THE RU-31 COMPOUND AND CYPROHEPTADINE, IN COMPARISON WITH PENTHOXYPHYLLINE (2021)

Migraine and its comorbid conditions are pathogenetically associated with many factors, including hemorheological disorders. A class of drugs with a 5-HT2A antagonistic mechanism of action, is promising for the prevention and treatment of migraine attacks and concomitant pathologies. The aim of the research is to study and compare a hemorheological activity of anti-migraine drugs, antagonists of 5-HT2A receptors of cyproheptadine, and a new drug that completed preclinical studies of the 1-(2-diethylaminoethyl)-2-(4-methoxyphenyl)-imidazo[1,2-a]benzimidazole derivative of the RU- 31 compound. Materials and methods . The study of the hemorheological activity of the RU-31 compound and cyproheptadine, was carried out using an experimental model of rabbit blood hyperthermia in vitro . Pentoxifylline was used as a reference drug. In the course of the work, the parameters of blood viscosity, aggregation and deformability of erythrocytes were recorded. Results . It has been established that in the concentration of 1 μM, the RU-31 compounds reduce blood viscosity by 17% at high shear rates, which is comparable with pentoxifylline in the concentration of 100 μM on the activity level. In the concentration of 1 μM, cyproheptadine also causes a general tendency to reduce blood viscosity at high shear rates, being inferior in activity to the RU-31 compound and pentoxifylline. In the concentration of 1 μM, the RU-31 compound has a pronounced effect on the aggregation ability of erythrocytes in autologous plasma, reducing the aggregation rate by 70%, while the level of activity is not inferior to the drug compared to pentoxifylline in the concentration of 100 μM, and surpasses the drug cyproheptadine. For the RU-31 compound and cyproheptadine, no significant effect on the deformability of erythrocytes has been shown. Conclusion . The capacity of cyproheptadine and the RU-31 compound to influence the rheological properties of blood by reducing blood viscosity and aggregation of erythrocytes has been revealed.
イメージフェノメナンからレッジョ・エミリアを問う -教育における映像の可能性に対する考察 (2012)

Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.
The Development of an Experimental Four-Wheel-Steering Vehicle (1986)

&lt;div class="htmlview paragraph"&gt;This paper describes the development of a vehicle with four-wheel steering in which the rear wheels can be controlled electronically in addition to the conventional front-wheel steering system. In the method for steering the rear wheels, the side-slip angle at the vehicle's center of gravity is maintained at zero, which improves the basic dynamic properties of the vehicle. This approach allows greater maneuverability at low speed by means of counter-phase rear steering and improved stability at high speed through same-phase rear steering.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;However, the use of counter-phase rear steering to improve maneuverability gives rise to problems in regard to practicality. In addition, continuously controlled four-wheel steering, using counter-phase at low speed and same-phase at high speed, leads to many other problems regarding practicality because of the strong apparent understeer characteristics.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Therefore a selection must be made between two approaches if a vehicle with four-wheel steering is to become a practical reality. That is, either sepatate systems must be adopted for low and high speed use, or a four-wheel steering system must be designed that would apply active steering to the front wheels as well.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper further describes an optimum control system based on active steering at both front and rear wheels, which brings out the maximum effects of four-wheel steering.&lt;/div&gt;
Human walking animation based on foot reaction force in the three-dimensional virtual world (2000)

This paper introduces a method that can generate continuous human walking motion automatically on an arbitrary path in a three-dimensional (3D) modelled scene. The method is based on a physical approach that solves the boundary value problem. In the motion generation stage, natural-looking walking motion, which includes plane walking, walking upstairs and downstairs and walking on a curved path, is created by applying dynamics and kinematics. The human body is approximated as a simple rigid skeleton model, and dynamic motion is created based on the ground reaction force of the human foot. To adapt to the 3D environment, the 3D walking path is divided into steps which are tagged with the parameters needed for motion generation, and step-by-step motion is connected end-to-end. Additional features include fast calculation and a reduced need for user control. The proposed method can produce interesting human motion and can create realistic computer animation scenes. Copyright © 2000 John Wiley & Sons, Ltd.
Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling (1996)

In contrast to mature B cells, immature stage B cells do not proliferate following Ag receptor cross-linking with anti-Ig Abs. To determine where in the cell cycle immature B cells arrest, we have examined the expression of specific G, cell cycle regulators. Following surface IgM (sIgM) cross-linking on mature B cells, we observed increased expression of the early G1 kinase, cyclin-dependent kinase 4 (cdk4), and one of its regulatory subunits, cyclin D2. Mature B cells also showed increased expression of components required for G1/S transition, including cyclin E and cdk2. Whereas immature stage B cells increased expression of cyclin D2 and cdk4 after anti-IgM stimulation, unlike mature stage B cells they failed to express cyclin E and cdk2. Expression of cyclin D2 and cdk4 indicates that these cells can exit G0 and enter the initial G1 phase following sIgM ligation. Interestingly, IL-4, which by itself does not stimulate proliferation of immature B cells, induced expression of cyclin E and cdk2. These latter results suggest that IL-4 complements sIgM, signaling for proliferation by increasing the basal levels of late G1 cell cycle regulators. Consistent with this idea, IL-4 synergizes with anti-Ig Abs to promote cell cycle progression and proliferation of immature B cells. Finally, c-myc, a transcriptional regulator of some members of the cell cycle machinery, is not induced following sIgM cross-linking of immature cells. This lack of inducible expression contrasts with that seen in mature stage B cells, and in immature stage cells stimulated to proliferate with LPS. These results suggest that c-myc may be a component of the signaling pathway that induces cyclin E and cdk2 expression.
in vivo Brain Imaging with Adaptive Optical Microscope (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text K. Wang, W. Sun, N. Ji, and E. Betzig, "in vivo Brain Imaging with Adaptive Optical Microscope," in Conference on Lasers and Electro-Optics, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper AM4O.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Creep and shrinkage behavior of improved ultrathin polymeric films (2002)

Abstract Long‐term creep‐deformation and shrinkage characteristics of improved ultrathin polymeric films for magnetic tapes are presented. These films include poly(ethylene terephthalate) (PET), poly(ethylene naphthalate) (PEN), and aromatic polyamide (ARAMID). PET film is currently the standard substrate used for magnetic tapes, and thinner tensilized‐type PET, PEN, and ARAMID have recently been used as alternate substrates with improved material properties. The thickness of the films ranges from 6.2 to 4.8 μm. More dimensional stability is required for advanced magnetic tapes, and the study of creep and shrinkage behavior is important for estimating the dimensional stability. Creep measurements were performed on all available substrates at 25, 40, and 55°C for 100 h. Based on these data, master curves were generated using time–temperature superposition to predict dimensional stability after several years. The amount of creep deformation is considerably smaller for ARAMID and tensilized‐type PET than for PEN, although Standard PET shows the largest amount of creep. In addition, creep measurements under high humidity also show similar trends. Shrinkage measurements at 55°C for 100 h show that the shrinkage of ARAMID is lower than that of PET and PEN. The relationship between the polymeric structure and dimensional stability are also discussed. Based on the creep and shrinkage behavior, ARAMID and tensilized‐type PET seem to be suitable for advanced magnetic tapes. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 84: 1477–1498, 2002; DOI 10.1002/app.10012
Filling factor and electronic structure ofDy3N@C80filled single-wall carbon nanotubes studied by photoemission spectroscopy (2006)

We report on a detailed study of the filling factor and electronic structure of the trimetal nitride fullerene ${\mathrm{Dy}}_{3}\mathrm{N}@{\mathrm{C}}_{80}(\mathrm{I})$ filled single-wall carbon nanotubes (SWCNTs), the so-called endohedral peapods $({\mathrm{Dy}}_{3}\mathrm{N}@{\mathrm{C}}_{80}@\mathrm{SWCNTs})$, using photoemission spectroscopy as a probe. The photoemission response close to the Fermi energy exhibits the manifestation of one-dimensional electronic structures, i.e., van Hove singularities and a power-law (Tomonaga-Luttinger liquid) behavior. Within the experimental accuracy the spectral shapes are the same as those of the pristine SWCNTs reference sample. From a comparison between the valence-band spectra of the peapods and the SWCNT measured with $400\phantom{\rule{0.3em}{0ex}}\mathrm{eV}$ photon energy, we determine the bulk filling of ${\mathrm{Dy}}_{3}\mathrm{N}@{\mathrm{C}}_{80}@\mathrm{SWCNTs}$ to be $74\ifmmode\pm\else\textpm\fi{}10\phantom{\rule{0.2em}{0ex}}%$. In addition, from a detailed analysis of the resonant photoemission across the Dy $4d\text{\ensuremath{-}}4f$ edge, we show that the effective Dy valency of ${\mathrm{Dy}}_{3}\mathrm{N}@{\mathrm{C}}_{80}@\mathrm{SWCNTs}$ is about 3.0 which is slightly larger than for ${\mathrm{Dy}}_{3}\mathrm{N}@{\mathrm{C}}_{80}$.
SURGICAL CORRECTION OF FUNNEL CHEST WITH CONGENITAL HEART DISEASE (1985)

Funnel chest is often associated with some other congenital disease. Over one hundred and fifty patients with funnel chest had been operated upon for surgical correction in our department by August 1983. Three patients had congenital heart disease and were treated by a one-stage or two-stage operation for the combination of funnel chest and heart disease. Two of them had atrial septal defects (ASD) and the other had a patent ductus arteriosum. One of the ASD patients was treated by a one-stage operation and the others by a two-stage one. The cosmetic results of the one-stage operation were superior to those of the two-stage one. Sternal turnover with the abdominal rectal muscle had the benefit of preservation of the resected sternum during extracorporeal circulation and good cosmetic results postoperatively. However, secure fixation for the removed sternum and careful hemostasis was necessary for a successful one-stage operation.
Group 4 Metal Mono-Dicarbollide Piano Stool Complexes. Synthesis, Structure, and Reactivity of (.eta.5-C2B9H11)M(NR2)2(NHR2) (M = Zr; R = Et; M = Ti, R = Me, Et) (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGroup 4 Metal Mono-Dicarbollide Piano Stool Complexes. Synthesis, Structure, and Reactivity of (.eta.5-C2B9H11)M(NR2)2(NHR2) (M = Zr; R = Et; M = Ti, R = Me, Et)Daniel E. Bowen, Richard F. Jordan, and Robin D. RogersCite this: Organometallics 1995, 14, 8, 3630–3635Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/om00008a009https://doi.org/10.1021/om00008a009research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Errors-and-erasures coding to combat impulse noise on digital subscriber loops (1990)

The issue addressed is how closely ideal performance can be approached using a practical erasure declaration mechanism. A description is given of a specific practical erasure declaration mechanism, and the resulting coded system performance is investigated on the digital subscriber loop. Results indicate that, by appropriate choice of system parameters, it is possible to closely approach the ideal performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Pose-Guided Human Parsing with Deep Learned Features (2015)

Parsing human body into semantic regions is crucial to human-centric analysis. In this paper, we propose a segment-based parsing pipeline that explores human pose information, i.e. the joint location of a human model, which improves the part proposal, accelerates the inference and regularizes the parsing process at the same time. Specifically, we first generate part segment proposals with respect to human joints predicted by a deep model, then part- specific ranking models are trained for segment selection using both pose-based features and deep-learned part potential features. Finally, the best ensemble of the proposed part segments are inferred though an And-Or Graph. We evaluate our approach on the popular Penn-Fudan pedestrian parsing dataset, and demonstrate the effectiveness of using the pose information for each stage of the parsing pipeline. Finally, we show that our approach yields superior part segmentation accuracy comparing to the state-of-the-art methods.
Understanding 2D-BarCode Technology and Applications in M-Commerce - Design and Implementation of A 2D Barcode Processing Solution (2007)

With the swift increase of the number of mobile device users, more wireless information services and mobile commerce applications are needed. Since various barcodes have been used for decades as a very effective means in many traditional commerce systems, today people are looking for innovative solutions to use barcodes in the wireless world. Recently, the mobile industry began to pay more attention to barcode applications in m-commerce because 2D-barcodes not only provide a simple and inexpensive method to present diverse commerce data, but also improve mobile user experience by reducing their inputs. This paper first discusses 2D-barcode concepts, types and classifications, major technology players, and applications in mobile commerce. Then, it reports a research project to develop a 2D-barcode processing solution to support mobile applications. Moreover, the paper also presents the application examples, and case study using the solution.
Transition relevance place (2006)

In this paper, we describe how users transfer language behavior commonly associated with directed dialog to natural language systems: they respond to the initial prompt with a single word (holophrase) instead of the naturally occurring unit of conversation (a sentence). We evaluate two solutions to this problem and offer a conversational turn-taking method together with a discourse clause tutorial as the effective way to get repeat callers to adapt to the natural language dialog style.
Palladium-Catalyzed Coupling of Two Alkynes and an Alkenyl Iodide:  Formation of Pentasubstituted Fulvenes (2001)

[reaction: see text]. Disubstituted alkynes reacted with alkenyl iodide in the presence of a catalytic amount of Pd(OAc)2 and Ag2CO3 to give pentasubstituted fulvene derivatives in excellent yields. Other Ag salts such as AgNO3, AgBF4, and AgOTf are not effective, whereas a combination of AgNO3 and K2CO3 has a remarkable effect on the formation of fulvene.
Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and 2 protein of reovirus (1993)

A sequence motif that is conserved in a number of S-adenosylmethionine (SAM)-utilizing methyltransferases and is implicated in SAM binding was identified in the N-terminal portion of NS5 proteins of flaviviruses and in lambda 2 protein of reovirus. An additional conserved motif was shared by these viral proteins and two distinct groups of methyltransferases including as the prototypes Rhodobacter capsulatus hydroxyneurosporene methylase (crtF gene product) and yeast 3,4-dihydroxy-5-hexaprenylbenzoate methylase (COQ3 gene product), respectively. Statistically significant similarity was revealed between the region of flavivirus NS5 containing the SAM-binding motif and a newly characterized family of putative methyltransferases from bacteria, yeast and plants, which is related to the Coq3 group. Amino acid sequence signatures were derived that are unique for NS5 proteins and different subsets of (putative) cellular methyltransferases. It is hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping. Thus NS5 may be a two-domain protein, with its C-terminal domain comprising the RNA-dependent RNA polymerase. The putative methyltransferase domain of flaviviruses is unrelated to the methyltransferase domain previously characterized in positive-strand RNA viruses of the alphavirus-like supergroup. The lack of sequence similarity and different location of the putative methyltransferase domain underscores the drastic difference in the genome layout of flaviviruses and alphaviruses. The identification of the putative methyltransferase domain in reovirus lambda 2 protein is compatible with the available evidence that this protein is the viral capping enzyme.
A 7 DOF Wearable Robotic Arm Using Pneumatic Actuators (2001)

As human-friendly robot techniques improve, the concept of the wearability of robotic arms becomes important. A master arm that detects human arm motion and provides virtual forces to the operator is an embodied concept of a wearable robotic arm. The medical orthosis used in the medical rehabilitation can also be included in the category of a wearable robotic arm. For the application areas such as human-power amplification or virtual reality experience, a kind of wearable robotic arm is also needed. In this study, we design a 7 DOF wearable robotic arm with high joint torques. An operator wearing this robotic arm can move around freely because this robotic arm was designed to have its fixed point at the shoulder part of the operator. The proposed robotic arm uses parallel mechanis ms at the shoulder part and the wrist part on the model of the human muscular structure of an upper limb. To reduce the computational load in solving the forward kinematics and to prevent singularity motions of the parallel mechanism, yawing motion of the parallel mechanisms was separated using a slip ling mechanism. A small-size pneumatic proportional control valve was also developed to improve the response characteristics of pneumatic actuators and to reduce the total weight of the robotic arm. The total weight of the proposed robotic arm is about 4 kgf. Some motion and force tracking experiments were performed to evaluate the capability of pneumatic control system of the proposed robotic arm. Some application examples using robotic arm such as teleoperation and VR experience are also described to show its validity.
Real-Time Correction of Intensity Nonlinearities in Imaging Systems (1977)

An analysis of two-dimensional imaging systems with general intensity nonlinearities is presented and several methods for real-time correction are discussed. Exact correction for measurement purposes and approximate correction for the human observer are described, and system implementation is by digital hardware, primarily using programmable read-only memories (PROM's). Calibration techniques for these systems are given, and estimates of computing time and required system complexity are made. Experimental application of these techniques is discussed.
Carbonyl‐Olefin‐Kreuzmetathese mittels Licht‐induzierter 1,3‐Diol‐Bildung‐ und Fragmentierungssequenz (2018)

Abstract Eine durch sichtbares Licht vermittelte Carbonyl‐Olefin‐Kreuzmetathese wird beschrieben. Photoinduzierte Lochkatalyse ermöglicht ausgehend von Aldehyden und Styrolen die Bildung von 1,3‐Diolen, die anschließend unter sauren Bedingungen direkt zu Kreuzmetatheseprodukten fragmentieren. Die Verwendung von 1,3‐Diolen als Intermediate anstelle der energetisch anspruchsvolleren Oxetane liefert eine neue, orthogonale Strategie für die Carbonyl‐Olefin‐Kreuzmetathese. Darüber hinaus erfordert dieser Ansatz keine Metalle, Liganden oder Additive und liefert die Produkte mit einer hohen E ‐Selektivität. Ein möglicher Mechanismus wird gezeigt, erklärt und durch theoretische Berechnungen sowie Experimente belegt. Weiterhin wird eine praktische Synthese eines neuen Photokatalysators auf Acridiniumbasis inklusive vollständiger Charakterisierung vorgestellt.
Conjugate additions to α,β-unsaturated sulphoxides: syntheses of cyclopentenones and 9-deoxyprostanoids (1984)

1,4- Dicarbonyl compounds, and hence cyclopentenone derivatives, were prepared by conjugate additions of enolate and related anions to α,β-unsaturated sulphoxides, followed by sulphoxide–ketone transformations. These transformations involved trapping the intermediate α-sulphinyl carbanions with dimethyl disulphide to give thioacetal monoxide derivatives, or Pummerer rearrangements of the sulphoxides to give alkenyl sulphides. 3-Substituted 2-ethoxycarbonylcyclopentenones prepared in this way were converted into 9-deoxyprostanoids and their 12-ethoxycarbonyl derivatives, the latter by use of 2-phenylsulphinyloct-1-en-3-one as an electrophilic prostanoid β-side-chain precursor.