gebhart/patrepeval huggingface dataset:
FLT3 mutations in canine acute lymphocytic leukemia (2011)

These results show that ALL and FLT3 biology is conserved between canine and human patients, supporting the notion that canine ALL, in conjunction with the GL-1 cell line, will be useful in the development of a relevant large animal model to aid in the study of human FLT3 mutant leukemias.
Estimating Sparsity Level for Enabling Compressive Sensing of Wireless Channels and Spectra in 5G and Beyond (2020)

Applying compressive sensing (CS) allows for sub-Nyquist sampling in several application areas in 5G and beyond. This reduces the associated training, feedback, and computation overheads in many applications. However, the applicability of CS relies on the validity of a signal sparsity assumption and knowing the exact sparsity level. It is customary to assume a foreknown sparsity level. Still, this assumption is not valid in practice, especially when applying learned dictionaries as sparsifying transforms. The problem is more strongly pronounced with multidimensional sparsity. In this paper, we propose an algorithm for estimating the composite sparsity lying in multiple domains defined by learned dictionaries. The proposed algorithm estimates the sparsity level over a dictionary by inferring it from its counterpart with respect to a compact discrete Fourier basis. This inference is achieved by a machine learning prediction. This setting learns the intrinsic relationship between the columns of a dictionary and those of such a fixed basis. The proposed algorithm is applied to estimating sparsity levels in wireless channels, and in cognitive radio spectra. Extensive simulations validate a high quality of sparsity estimation leading to performances very close to the impractical case of assuming known sparsity.
A Picoliter-Volume Mixer for Microfluidic Analytical Systems (2001)

Mixing confluent liquid streams is an important, but difficult operation in microfluidic systems. This paper reports the construction and characterization of a 100-pL mixer for liquids transported by electroosmotic flow. Mixing was achieved in a microfabricated device with multiple intersecting channels of varying lengths and a bimodal width distribution. All channels running parallel to the direction of flow were 5 microm in width whereas larger 27-microm-width channels ran back and forth through the parallel channel network at a 45 degrees angle. The channel network composing the mixer was approximately 10 microm deep. It was observed that little mixing of the confluent solvent streams occurred in the 100-microm-wide, 300-microm-long mixer inlet channel where mixing would be achieved almost exclusively by diffusion. In contrast, after passage through the channel network in the approximately 200-microm-length static mixer bed, mixing was complete as determined by confocal microscopy and CCD detection. Theoretical simulations were also performed in an attempt to describe the extent of mixing in microfabricated systems.
Improving P2P video streaming in wireless mesh networks (2010)

P2P Video Streaming has become a reliable and efficient solution for distributing video on the Internet. Similarly to regular P2P file-sharing, all the participating nodes exchange information. Wireless Mesh Networks, in turn, can be seen as a cost-effective solution to extend Internet access networks. In this paper we propose improvements to P2P Video Streaming. These improvements can provide gains in scenarios where the service is deployed over Wireless Mesh Networks and the nodes are simultaneously peers and packet forwarders. By using cross-layer interactions between application and network layers, we show that the proposed improvements reduce substantially the amount of traffic in the network.
LADAR And FLIR Based Sensor Fusion For Automatic Target Classification (1989)

The purpose of this report is to show results of automatic target classification and sensor fusion for forward looking infrared (FLIR) and Laser Radar sensors. The sensor fusion data base was acquired from the Naval Weapon Center and it consists of coregistered Laser RaDAR (range and reflectance image), FLIR (raw and preprocessed image) and TV. Using this data base we have developed techniques to extract relevant object edges from the FLIR and LADAR which are correlated to wireframe models. The resulting correlation coefficients from both the LADAR and FLIR are fused using either the Bayesian or the Dempster-Shafer combination method so as to provide a higher confidence target classifica-tion level output. Finally, to minimize the correlation process the wireframe models are modified to reflect target range (size of target) and target orientation which is extracted from the LADAR reflectance image.
Erratum: X-Ray Diffraction Investigation of β′-NiAl Alloys (1972)

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Data from eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival (2023)

&lt;div&gt;Abstract&lt;p&gt;Elevated eukaryotic translation initiation factor 4E (eIF4E) function induces malignancy in experimental models by selectively enhancing translation of key malignancy-related mRNAs (c-myc and BCL-2). eIF4E activation may reflect increased eIF4E expression or phosphorylation of its inhibitory binding proteins (4E-BP). By immunohistochemical analyses of 148 tissues from 89 prostate cancer patients, we now show that both eIF4E expression and 4E-BP1 phosphorylation (p4E-BP1) are increased significantly, particularly in advanced prostate cancer versus benign prostatic hyperplasia tissues. Further, increased eIF4E and p4E-BP1 levels are significantly related to reduced patient survival, whereas uniform 4E-BP1 expression is significantly related to better patient survival. Both immunohistochemistry and Western blotting reveal that elevated eIF4E and p4E-BP1 are evident in the same prostate cancer tissues. In two distinct prostate cancer cell models, the progression to androgen independence also involves increased eIF4E activation. In these prostate cancer cells, reducing eIF4E expression with an eIF4E-specific antisense oligonucleotide currently in phase I clinical trials robustly induces apoptosis, regardless of cell cycle phase, and reduces expression of the eIF4E-regulated proteins BCL-2 and c-myc. Collectively, these data implicate eIF4E activation in prostate cancer and suggest that targeting eIF4E may be attractive for prostate cancer therapy. [Cancer Res 2009;69(9):3866–73]&lt;/p&gt;&lt;/div&gt;
Increased expression of CD208 (DC‐LAMP) in epidermal keratinocytes of psoriatic lesions (2009)

Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation and infiltration of inflammatory leukocytes. The aim of this study was to clarify the role of innate immunity involving dendritic cells (DC) and keratinocytes in psoriasis. We immunohistochemically examined the expression of DC markers such as CD1a, CD83, CD207 (Langerin), CD208 (DC-LAMP) and CD209 (DC-SIGN) in psoriatic skin and gamma-interferon (IFN-gamma)/12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated keratinocytes in vitro. CD208 was strongly expressed in basal and suprabasal layer keratinocytes in addition to DC in the perivascular lesions of the psoriatic dermis. Furthermore, the enhanced expression of CD208 in the perinuclear lesions of IFN-gamma-/TPA-stimulated keratinocytes was observed in vitro. Because a defect of the granular layer in psoriatic lesions has been recognized, increased expression of lysosome-related CD208 in the basal and suprabasal keratinocytes of psoriatic lesions might represent aberrant epidermal differentiation. Additionally, these CD208-positive keratinocytes possessing putative antigen-processing activity might play a key role as antigen-presenting cells in psoriatic skin.
Transition-element doping effects inLa0.7Ca0.3MnO3 (1999)

The influence of transition element (TE) doping on the magnetotransport properties of ${\mathrm{La}}_{0.7}{\mathrm{Ca}}_{0.3}{\mathrm{MnO}}_{3}$ is studied for the entire transition element series ($\mathrm{T}\mathrm{E}=\mathrm{C}\mathrm{r},$ Fe, Co, Ni, Cu, Zn) for a fixed (5% at Mn sites) dopant concentration. The systematics of different properties such as the metal-insulator transition temperature ${T}_{p},$ the Curie temperature ${T}_{c},$ $\ensuremath{\rho}{(T}_{p}),\ensuremath{\rho}(5\mathrm{K}),$ and the maximum value of magnetoresistance (MR), with respect to lattice parameter and the ionic radii of dopants, are examined. The important findings include an interesting correlation between the maximum MR, the lattice parameter, and the ionic radii, and some distinct features exhibited by Fe, Cu, and Zn dopants.
Newly established LC-MS/MS method for measurement of plasma BH4 as a predictive biomarker for kidney injury in diabetes (2021)

Our established LC-MS/MS method could be used on human plasma BH4 measurements and our data suggested that BH4 level can be used as a biomarker for kidney injury in diabetes indicated by its association with ACR progression and early renal function decline.
Measuring displacement currents during fabrication of Mg/Si Schottky diodes due to band-bending evolution (2018)

The generation of a rectifying metal-semiconductor contact forms a charge depletion layer in the semiconductor surface. The resulting space charge leads to a surface band bending and the formation of a Schottky barrier. The present study introduces an unconventional method to measure and monitor the surface band bending during metal atom deposition by recording the displacement current between the metal and the semiconductor. Magnesium atoms are evaporated at 130 K onto hydrogen-passivated p-Si(001) surfaces. During deposition, the time-dependent reverse current in the diode is detected. A sharp current peak of a few nA can be attributed to the displaced charge when the first monolayers of the Mg film are formed. The currents are proportional to the number of Mg atoms impinging onto the surface. Integrating the observed displacement currents over time yields the total space charge densities at the interface between 8 and 23 nC/cm2. This is in excellent agreement with the calculated value for a Schottky barrier of 0.5 eV and assuming flatband condition for hydrogen-passivated Si(001) surfaces.
Magnetic tunnel junctions with ZnSe barriers (2003)

Magnetic tunnel junctions with ZnSe barriers were fabricated with a combination of magnetron sputtering, ion beam sputtering, and effusion cell evaporation. Tunneling magnetoresistance values of ∼10% are observed at room temperature. The temperature and barrier thickness dependences of the junction resistance and tunneling magnetoresistance are consistent with a predominant direct tunneling mechanism when the barrier thickness is less than ∼10 nm thick.
Surface Engineering and Design Strategy for Surface‐Amorphized TiO2@Graphene Hybrids for High Power Li‐Ion Battery Electrodes (2015)

<b>Surface amorphization</b> provides unprecedented opportunities for altering and tuning material properties. Surface-amorphized TiO<sub>2</sub>@graphene synthesized using a designed low temperature-phase transformation technique exhibits significantly improved rate capability compared to well-crystallized TiO<sub>2</sub>@graphene and bare TiO<sub>2</sub> electrodes. These improvements facilitates lithium-ion transport in both insertion and extraction processes and enhance electrolyte absorption capability.
Grafting Short Peptides onto Polybutadiene‐block‐poly(ethylene oxide): A Platform for Self‐Assembling Hybrid Amphiphiles (2006)

Durch das Anbinden eines hydrophoben Peptids an Polybutadien-block-polyethylenoxid verschieben sich die Morphologien des Systems in Wasser zu solchen mit geringerer Krümmung – von kugelförmigen Micellen zu wurmartigen Micellen und Vesikeln (siehe Bild; PBD=Polybutadien, PEO=Polyethylenoxid, wEO: Gewichtsanteil des hydrophilen PEO-Blocks). Zudem treten als Folge von Peptidwechselwirkungen im hydrophoben Kern helicale Überstrukturen auf.
Assessment of Babesia bovis 6cys A and 6cys B as components of transmission blocking vaccines for babesiosis (2021)

These data, combined with similar work performed on Plasmodium 6cys proteins, indicate that an effective 6cys protein-based TBV against B. bovis will require identifying and targeting selected regions of proteins containing epitopes able to reduce transmission.
Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR‐Chk1 pathway (2010)

At clinically relevant doses, chemotherapeutic S N 1 DNA methylating agents induce an ATR‐mediated checkpoint response in human cells that is dependent on functional mismatch repair activities MutSα and MutLα. To better understand the mechanisms linking mismatch repair to ATR‐Chk1 checkpoint activation, we have systematically examined interactions of human MutSα and MutLα with proteins of the ATR‐Chk1 pathway using both nuclear extracts and purified proteins. Using nuclear co‐immunoprecipitation, we have detected interaction of MutSα with ATR, TopBP1, BRCA1, Claspin and Chk1, and interaction of MutLα with TopBP1, BRCA1 and Claspin. We were unable to detect interaction of MutSα or MutLα with Rad17, Rad9 or RPA in the extract system. Use of purified proteins confirmed direct interaction of MutSα with ATR, TopBP1 and Chk1, and MutLα with TopBP1. Use of a modified chromatin immunoprecipitation assay showed that PCNA, ATR, TopBP1, and Chk1 are recruited to chromatin in a MutLα‐ and MutSα‐dependent fashion after treatment with N ‐methyl‐ N ′‐nitro‐ N ‐nitrosoguanidine. While our failure to observe chromatin enrichment of RPA, Claspin, Rad17‐RFC, and Rad9‐Rad1‐Hus1 could be due to sensitivity limitations, these observations may indicate a novel mechanism for ATR activation. This study was financially supported by the National Institute of General Medical Sciences and the Howard Hughes Medical Institute.
Working Group Report: Dark Energy and CMB (2013)

The American Physical Society's Division of Particles and Fields initiated a long-term planning exercise over 2012-13, with the goal of developing the community's long term aspirations. The sub-group "Dark Energy and CMB" prepared a series of papers explaining and highlighting the physics that will be studied with large galaxy surveys and cosmic microwave background experiments. This paper summarizes the findings of the other papers, all of which have been submitted jointly to the arXiv.
Room-temperature Q-switching of Nd:YAG by F2− color centers in LiF (1986)

We report recent research on the passive Q-switch properties of F2−:LiF, a color center material of keen interest for solid-state laser designs because of its saturation behavior at high intensity levels. Previously, color centers were thought to be subject to thermal and optical degradation in such operation. Early work has shown that F2−:LiF can achieve Q-switched Nd:YAG laser action.1,2 Now we have verified and demonstrated repeatable G-switching performance for over 106 shots at 20 Hz at room temperature.
Acoustic emission in asphalt mixtures at low temperature (2026)

The objective of the research was to investigate the use of acoustic emission to analyze the microstructural phenomena of damage and the corresponding macroscopic behavior in asphalt mixtures tested at low temperature. An acoustic emission system with eight channels of recording was used to monitor the specimens tested in creep and in strength testing. The source location and the AE event count were used to illustrate the relationship between the micro damage and macroscopic behavior for the two different test conditions. The analysis indicates that a damage zone develops in both the creep and the strength tests. The damage zone changes with the test temperature and the loading level applied during the creep test.
Variables Influencing the Thrombostat 4000: Recommended Standardization (1995)

The in vitro bleeding test (IVBT) (Thrombostat 4000) was performed on blood samples from healthy blood donors using a "preliminary standard test." Only one factor of the test procedure was changed each time. We found the following parameters to have a significant influence on the test results: time interval between sampling and testing, diameter of the filter's aperture, capillary diameter, aggregating agents and their concentration, temperature of the blood and cartridges, method of drying the capillaries, the aspiration pressure, and the hematocrit of the blood sample. According to our data, we propose a standard IVBT for routine application and modifications for special diagnostic use.
A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice (2009)

The BCR-ABL tyrosine kinase is the defining feature of chronic myeloid leukemia (CML) and its kinase activity is required for induction of this disease. Current thinking holds that BCR-ABL forms a multi-protein complex that incorporates several substrates and adaptor proteins and is stabilized by multiple direct and indirect interactions. Signaling output from this highly redundant network leads to cellular transformation. Proteins known to be associated with BCR-ABL in this complex include: GRB2, c-CBL, p62(DOK), and CRKL. These proteins in turn, link BCR-ABL to various signaling pathways indicated in cellular transformation. In this study we show that a triple mutant of BCR-ABL with mutations of the direct binding sites for GRB2, CBL, p62(DOK) and CRKL, is defective for transformation of primary hematopoietic cells in vitro and in a murine CML model, while it retains the capacity to induce IL-3 independence in 32D cells. Compared to BCR-ABL, the triple mutant's ability to activate the MAP kinase and PI3-kinase pathways is severely compromised, while STAT5 phosphorylation is maintained, suggesting that the former are crucial for the transformation of primary cells, but dispensable for transformation of factor dependent cell lines. Our data suggest that inhibition of BCR-ABL-induced leukemia by disrupting protein interactions could be possible, but would require blocking of multiple sites.
IGG3 Reactive Rheumatoid Factor in Rheumatoid: Arthritis: Etiologic and Pathogenic: Considerations (1994)

Rheumatoid factor (RF) is a polyclonal autoantibody directed against the Fc portion of IgG. Although the role of RF in patients with rheumatoid arthritis (RA) is unclear, immune complexes that form between RF and IgG can activate the classical complement (C) pathway, leading to pathogenic outcomes involving inflammatory events and tissue damage. The specificity of serum RF and RF produced by rheumatoid synovial cells (RSC) is different. Serum RF has specificity for rabbit IgG and human IgG subclasses IgG1, 2, and 4, but binds poorly to IgG3. The affinity of serum RF for IgG Fc is low, having an association constant of 10(4)-10(5) M-1. RSC RF, however, has specificity for human IgG and high avidity for IgG3. Because of this greater specificity and avidity for IgG3, and because RSC RF may be pathogenically more important than serum RF, an important role for IgG3-reactive RF in RA may exist. Binding of RF to IgG may be dependent on the allotype and glycosylation of IgG. Infectious agents present in RA patients may directly or indirectly induce the production of certain RF. In this communication, we review and expand on several observations examining the role of IgG3-reactive RF in RA including: 1) binding differences between RF derived from RSC and serum; 2) glycosylation characteristics of IgG and its interaction with RF; 3) apparent allotype dependent binding of IgG3-reactive RF; and 4) possible relationship between infectious agents and the production of IgG3-reactive RF. Taken together, these observations suggest an important role for IgG3-reactive RF in better understanding the etiology and pathogenesis of RA.
Probabilistic affine invariants for recognition (2002)

Under a weak perspective camera model, the image plane coordinates in different views of a planar object are related by an affine transformation. Because of this property, researchers have attempted to use affine invariants for recognition. However, there are two problems with this approach: (1) objects or object classes with inherent variability cannot be adequately treated using invariants; and (2) in practice the calculated affine invariants can be quite sensitive to errors in the image plane measurements. In this paper we use probability distributions to address both of these difficulties. Under the assumption that the feature positions of a planar object can be modeled using a jointly Gaussian density, we have derived the joint density over the corresponding set of affine coordinates. Even when the assumptions of a planar object and a weak perspective camera model do not strictly hold, the results are useful because deviations from the ideal can be treated as deformability in the underlying object model.
Directional scale analysis for seismic interpretation (1999)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1999Directional scale analysis for seismic interpretationAuthors: Rutger L. C. van SpaendonckRichard G. BaraniukRutger L. C. van SpaendonckDelft University of Technology and Richard G. BaraniukRice Universityhttps://doi.org/10.1190/1.1820902 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1820902FiguresReferencesRelatedDetailsCited ByResearch on direction detection based on complex wavelet transformLocal complex‐valued correlation of seismic phasesThomas J. Browaeys21 October 2010Handwriting-based writer identification with complex wavelet transformNon-redundant, directionally selective, complex wavelets SEG Technical Program Expanded Abstracts 1999ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1999 Pages: 2061 publication data© 1999 Copyright © 1999 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 04 Jan 2005 CITATION INFORMATION Rutger L. C. van Spaendonck and Richard G. Baraniuk, (1999), "Directional scale analysis for seismic interpretation," SEG Technical Program Expanded Abstracts : 1844-1847. https://doi.org/10.1190/1.1820902 Plain-Language Summary PDF DownloadLoading ...
Microbiote et lymphocytes T (2013)

Les cellules de notre corps coexistent en permanence avec une flore microbienne extremement dense et variee. Ce microbiote colonise des la naissance la surface de notre peau et de la plupart de nos muqueuses, en particulier la muqueuse intestinale. Chez un sujet sain, la flore microbienne du tube digestif, compte un nombre de bacteries equivalent a au moins 10 fois le nombre de ses propres cellules [1]. Ces bacteries, qualifiees de commensales, forment un ecosysteme complexe avec lequel se sont etablies, au cours de l’evolution, des relations mutualistes progressant du commensalisme a une veritable symbiose. En effet, bien que les bacteries du microbiote intestinal utilisent a leur profit les ressources disponibles chez leur hote, elles exercent aussi des effets physiologiques benefiques pour celui-ci. Notamment, elles apportent des activites enzymatiques non codees par le genome de leur hote qui sont cruciales pour extraire l’energie provenant de son alimentation et modifient son metabolisme [2]. Le microbiote intestinal favorise egalement la maturation de l’intestin et celle du systeme immunitaire intestinal [2].