gebhart/patrepeval huggingface dataset:
MR imaging-related heating of deep brain stimulation electrodes: in vitro study. (2003)

A potential exists for excessive MR imaging-related heating in patients with deep brain stimulation electrodes; however, the temperature increases are linearly related to SAR values. Clinical imaging sequences that are associated with tolerable temperature elevations in the <or=2.0 degrees C range at the electrode tips can be performed safely within an SAR range <2.4 W/kg local (0.9 W/kg whole body averaged).
A new method of the chaos encryption (2002)

Chaos encryption is a new branch in the field of security of computer data. We introduce the concept of chaos encryption and submit a new method of chaos encryption. We analyze the merit of this algorithm and implement it with the C language. Some experiments are given.
Tuberous Sclerosis Complex 1: An Epithelial Tumor Suppressor Essential to Prevent Spontaneous Prostate Cancer in Aged Mice (2010)

The phosphoinositide 3-kinase (PI3K) pathway regulates mammalian cell growth, survival, and motility and plays a major pathogenetic role in human prostate cancer (PCa). However, the oncogenic contributions downstream of the PI3K pathway made by mammalian target of rapamycin complex 1 (mTORC1)-mediated cell growth signal transduction in PCa have yet to be elucidated in detail. Here, we engineered constitutive mTORC1 activation in prostate epithelium by a conditional genetic deletion of tuberous sclerosis complex 1 (Tsc1), a potent negative regulator of mTORC1 signaling. Epithelial inactivation was not immediately tumorigenic, but Tsc1-deficient mice developed prostatic intraepithelial neoplasia (mPIN) in lateral and anterior prostates by 6 months of age, with increasing disease penetrance over time. Lateral prostate lesions in 16- to 22-month-old mutant mice progressed to two types of more advanced lesions, adenomatous gland forming lesion (Type 1) and atypical glands embedded in massively expanded reactive stroma (Type 2). Both Type 1 and Type 2 lesions contained multiple foci of microinvasive carcinoma. Epithelial neoplastic and atypical stromal lesions persisted despite 4 weeks of RAD001 chemotherapy. Rapalogue resistance was not due to AKT or extracellular signal-regulated kinase 1/2 activation. Expression of the homeobox gene Nkx3.1 was lost in Tsc1-deficient mPIN, and it cooperated with TSC1 loss in mPIN initiation in doubly mutant Tsc1:Nkx3.1 prostatic epithelial knockout mice. Thus, TSC1 inactivation distal to PI3K and AKT activation is sufficient to activate a molecular signaling cascade producing prostatic neoplasia and focal carcinogenesis.
Narrative as deliberative argument (2014)

AbstractThis essay argues that narratives or stories are an essential communication mechanism that define the differences between two conflicting groups, especially in asymmetric conflicts. Stories told during conflict resolution experiences are typically assumed to be subjective and emotional versions of reality, but I argue that stories function as arguments. Stories provide a foundation for reasons and are used as evidence to justify positions; this makes them fundamentally argumentative in nature. Interaction data from various Israeli–Palestinian dialogue groups are used to display turns at talk that illustrate the functioning of narratives as arguments during deliberation.Keywords:: narrativeargumentdeliberationethnopolitical conflictcommunication Notes1. The data in Turns 1, 2 and 3 are extracted from an Israeli–Palestinian group encounter in June 1998. The participants were students from Tel Aviv and Beit Jalah and the encounter was held in Tantur, Jerusalem. The communication patterns vacillated between routine interaction and deliberation. All of the "stories" identified in the interaction served argumentative and broadly deliberative functions, although the encounter was not explicitly constructed to achieve deliberative goals. Except for the case of highly structured deliberative encounters, this sort of melding of interaction patterns is typical of encounters between these two groups.2. The story in this turn was extracted from a meeting of the Strategic Thinking and Analysis Team formed by IPCRI (Israeli–Palestinian Center for Research and Information). This is a roughly half Israeli and half Palestinian composed group that met in August 2006 during the second Lebanon War. The story displayed in Turn 4 has been edited very slightly for readability.
Hough Voting for 3D Object Recognition under Occlusion and Clutter (2012)

This work proposes a novel approach for the detection of free-form shapes in a 3D space. The proposed method matches 3D features through their descriptions to attain correspondences, then accumulates evidence of the presence of the object(s) being sought by verifying the consensus of correspondences within a 3D Hough space. Our approach is capable of recognizing 3D shapes under significant degree of occlusion and clutter and can deal with multiple instances of the shape to be recognized. We validate our proposal by means of a quantitative experimental comparison to the state of the art over two datasets acquired with different sensors (a laser scanner and a stereo camera) and characterized by high degrees of clutter and occlusion. In addition, we propose an extension of the approach to RGB-D (i.e., color and depth) data together with results concerning 3D object recognition from RGB-D data acquired by a Microsoft Kinect sensor.
A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis (2013)

Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential of BAT to counteract obesity and obesity-related diseases, including insulin resistance. Much progress has been made, particularly in the areas of BAT physiology in adult humans, developmental lineages of brown adipose cell fate, and hormonal control of BAT thermogenesis. As we enter into a new era of brown fat biology, the next challenge will be to develop strategies for activating BAT thermogenesis in adult humans to increase whole-body energy expenditure. This article reviews the recent major advances in this field and discusses emerging questions.
Dual Die Processor Package Design Optimization and Performance Evaluation (2006)

The quest for higher performance in microprocessors has steered the industry towards multi-core architectures which has significantly increased the challenges in silicon-package integration. In the past, designers have exploited parallelism through hyper threading (HT) technology where the operating system sees one physical processor as two logical processors. Even though HT simulates dual processing, the performance gain from HT is limited to applications that don't utilize same processor resources. For example if an application generates two floating point intensive threads, the execution of these threads would need to alternate with the single floating point unit and in most cases this would result in performance slow down. To address this problem, an integration of multiple dies to increase processor resources namely level1/level2 cache, registers, floating point units etc., is warranted so the execution of the threads can be done in parallel. Although this configuration is scalable and improves performance, adds considerable package design challenges to generate optimized solutions.
Toll‐like receptor 3 mediated hyperphosphorylation of tau in human SH‐SY5Y neuroblastoma cells (2006)

Abstract Neurofibrillary tangles of abnormally phosphorylated tau are one of the characteristic pathological hallmarks of Alzheimer's disease (AD). In addition, immunological and inflammatory changes including complements and activated microglia are also common phenomena in AD. However, these pathological changes are yet to be interlinked in a common explainable background. In this study, the relevant mechanism of phosphorylation of tau protein and an innate immune signal transduction system were investigated. Toll‐like receptor 3 (TLR3) is a receptor working in the innate immune system and its expression in the brain has already been reported. Total RNA was isolated from SH‐SY5Y cells and reverse transcriptase polymerase chain reaction was done to see endogenous expression of TLR3 in SH‐SY5Y cells that was further confirmed at protein level by Western blot analysis. Cells were treated with 50 µg/mL of polyinosinic–polycytidylic acid (pIpC), a synthetic analog of dsRNA and the changes of phosphorylation of tau protein were investigated. Further the level of phosphorylation of tau protein was investigated after the cells had been previously treated with 10 ng/mL of lipopolysaccharide (LPS) for 6 h to induce over‐expression of TLR3. Increased phosphorylation of tau protein at PHF‐1 site (Ser396/404), activation of Jun N‐terminal kinase and p38 MAPK were observed in cells treated with pIpC. These effects were enhanced when cells were pretreated with LPS, a known transducer of TLR3. These data suggest that toll‐like receptor 3, an innate immune molecule, might be a potential link to mediate hyperphosphorylation of tau in neurodegenerative processes of AD.
Investigating the effects of external pressure on coronary arteries with plaques and its role in coronary artery disease (2022)

The risk of an acute coronary event stems from the amount and type of plaque present, as well as the fluid and structural dynamics in the coronary artery. If the plaque’s structural stress exceeds the mechanical strength, the fibrous cap may rupture and lead to thrombosis. The patient is then likely to face a sudden myocardial infarction. An association between Coronary Heart Disease (CHD) and Sudden Cardiac Death (SCD) has been long recognised. For the first time, we are reporting a correlation between applied external pressure, such as Cardiopulmonary Resuscitation (CPR), coughing, sneezing, blowing one’s nose, etc., and diseased coronary artery plaque via 3 D coronary artery models and two-way Fluid-Solid Interaction (FSI) models. Shear and von Mises stresses inside arteries and plaques have been shown to play a major role in plaque development, progression of disease, and the likelihood of plaque rupture. Our results show a drastic change in maximum shear (300%) and von Mises stresses (500%) with increasing external pressure. This change may indicate an onset of imminent plaque rupture. Furthermore, FSI modelling indicates a strong correlation between plaque thickness, location, and external pressure. With further clinical and simulation studies, this information could be helpful in understanding potential limit pressure in the CPR process for patients with CHD.
Advanced mask-to-mask overlay analysis for next generation technology node reticles (2010)

Double Patterning Lithography (DPL) for next-generation wafer exposure is placing greater demands on the requirements for pattern placement accuracy on photomasks: the DPL mask pair must now meet the pattern placement specifications that a single mask was required to meet in previous generations. As a result, each mask in the mask pair must individually conform to much tighter mask registration specs. Minimizing all sources of systematic overlay error has become critical. In addition, the mask-to-mask overlay between the two masks comprising the DPL pair must be measured-a methodology shift from the current practice of referencing mask registration error only to design data. Characterizing mask-to-mask overlay error requires the ability to measure pattern placement errors using in-die structures on reticle pairs. Today's analysis methods do not allow for comparison of registration maps based on different site locations. This gap has created a lack of information about the true overlay impact of mask-to-mask registration errors on masks with few or no common features. A new mask-to-mask overlay analysis method is demonstrated that provides new flexibility for mask-to-mask comparison. This new method enables mask manufacturers to meet fab requirements for DPL, and it enables semiconductor manufacturers to verify if overlay deviations are within acceptable limits.
Patterns of usage in an enterprise file-sharing service (2010)

How do people use an enterprise file-sharing service? We describe patterns of usage in a social file-sharing service that was deployed in a large multinational enterprise. Factor analyses revealed four factors: Upload & Publicize (regarding one's own files); Annotate & Watch (add information to files and maintain awareness); Discover & Tell (find files uploaded by other users, and communicate to additional users about those files); and Refind (re-use one's own files). We explore the attributes of users who score highly on each of these factors, and we propose implications for design to encourage innovation in usage.
Supplementary Figures 1-7, Tables 1-4 from von Hippel-Lindau–Dependent Patterns of RNA Polymerase II Hydroxylation in Human Renal Clear Cell Carcinomas (2023)

Supplementary Figures 1-7, Tables 1-4 from von Hippel-Lindau–Dependent Patterns of RNA Polymerase II Hydroxylation in Human Renal Clear Cell Carcinomas
A New Process to Deposit Thin Coatings by Injecting Nanoparticle Suspensions in a dc Plasma Jet (2002)

Abstract This paper describes a new spraying process that uses a special torch to inject aluminum oxide suspensions into a dc plasma jet. Based on the results obtained, a general mechanism of action is proposed in which factors such as acceleration, impact behavior, and heat transfer phenomena play a role. Paper includes a German-language abstract.
Radiotherapy of metastatic renal cell carcinoma. (1988)

Modern oncological treatment of metastatic renal cell carcinoma may have different goals: first of all, improvement of survival rates; secondly, elimination of symptoms like pain from osseous lesions or disorders of central nervous system functions. Chemotherapy or radiotherapy or the combination of both should improve life quality and be tolerable to the patient. Close interdisciplinary contacts of medical and radiological oncologists are therefore necessary. Radiotherapy should be carried out under conditions of high-voltage energy and modern treatment planning to concentrate and limit the irradiation volume as much as possible. Split-course technique and radiation as interval treatment between chemotherapy courses seem to be optimal. Our clinical results indicate that the reported radioresistance of renal cell carcinoma might result from radiobiological and methodological misinterpretations.
La doctrina de San Juan Damasceno sobre la muerte y la asunción de María al cielo, y su posible influencia en las correspondientes iconografías medievales [The doctrine of St John of Damascus on the death and the assumption of Mary into heaven...] (2017)

Este articulo pretende poner en luz la influencia que la doctrina de San Juan Damasceno (c. 675-c. 749) sobre la muerte, la resurreccion y la asuncion de la Virgen Maria podria haber ejercido sobre las complementarias iconografias medievales de la Dormicion y la Asuncion de Maria al cielo. El trabajo tiene dos vertientes esenciales. En la primera, mediante el analisis de tres homilias del Damasceno sobre la Dormicion de Maria, se estudia la posicion conceptual de dicho autor sobre la muerte, el sepelio y la asuncion del alma de la Virgen, asi como su resurreccion anticipada y su ascencion en cuerpo y alma al cielo. En la segunda vertiente se interpretan algunas obras pictoricas medievales de la Dormicion y la Asuncion de Maria al cielo desde la perspectiva doctrinal de San Juan Damasceno, poniendo en directa correspondencia los elementos narrativos contenidos en dichas pinturas con lo formulado por el teologo sirio en sus tres homilias sobre la Dormicion. This paper aims to highlight the influence that the doctrine of St John of Damascus (c.675-c.749) on the death, resurrection and assumption of the Virgin Mary could have exercised over the complementary medieval iconographies of the Dormition and the Assumption of Mary into heaven. The article has two essential sides. In the first one, through the analysis of three homilies of Damascene on the Dormition of Mary, we deal with the author's conceptual position on death, burial and the assumption of the soul of the Virgin, as well as with her anticipated resurrection and her assumption in body and soul into heaven. In the second side, some medieval paintings of the Dormition and the Assumption of Mary into heaven are interpreted from the doctrinal perspective of St John Damascene, putting in direct correspondence the narrative elements contained in these paintings with the formulations of the Syrian theologian in his three homilies on the Dormition.
Special and New Monolithics (2012)

The paper shows the constituents and technical properties of low calcium aluminates cement concretes with ultra dispersed mineral powders and admixtures.
KnowledgeLink update: just-in-time context-sensitive information retrieval. (2003)

Medical knowledge expands at a pace that makes it impossible for the individual clinician to keep up, especially for medications. Medication-related queries are the most common type of query that typically go unanswered during the course of providing care.1 Unanswered questions may result in errors, as found in one study evaluating systems failures associated with adverse drug events. This study found that better information might have prevented half of serious medication errors, and that lack of drug-specific knowledge accounted for the single largest proportion of these events (29%).2 While this information was available somewhere (either on paper or electronically), it was not at the providers' fingertips. Information technology should anticipate clinicians' needs, and bring the information they require to the point of care. For this purpose, we developed an application extender called KnowledgeLink, which provides "just-in-time" context-sensitive information retrieval for drug-related queries.
Effect of theophylline on the initiation phase of postischemic acute renal failure in rats. (1986)

These experiments were designed to test, pharmacologically, the hypothesis that adenosine mediates the reduction in glomerular filtration rate (GFR) observed during the initiation phase of postischemic acute renal failure (ARF). Six groups of pentobarbital-anesthetized rats were studied; in all groups, the left renal arteries were completely occluded for either 30 or 45 minutes, and 30 minutes after relieving the occlusion, two consecutive 40-minute clearances were begun. Two control groups received no pretreatment; two experimental groups were pretreated with intravenous theophylline (24 mumol/kg prime followed by 0.28 mumol/min/kg infusion); two further experimental groups were pretreated with a higher dose of theophylline (111 mumol/kg prime followed by 1.1 mumol/min/kg infusion). As assessed by reduction in inulin clearance, the impairment of GFR was directly related to the duration of ischemia. The lower dose of theophylline had no significant effects on inulin clearances of right or left kidneys in either group (previously ischemic for 30 or 45 minutes). The higher dose of theophylline also had no significant effects on right kidney inulin clearances, but it significantly increased the inulin clearances of left kidneys previously ischemic for 30 to 45 minutes. This theophylline-induced increase in inulin clearance after 30 minutes of ischemia was accompanied by an increase in renal plasma flow. Because theophylline is a competitive antagonist at adenosine receptors, these results are consistent with the hypothesis that endogenous adenosine mediates, at least in part, the hemodynamic changes in postischemic ARF in rats.
Successful treatment of severe psoriatic arthritis with infliximab in an 11-year-old child suffering from linear psoriasis along lines of Blaschko (2007)

Journal Article Successful treatment of severe psoriatic arthritis with infliximab in an 11‐year‐old child suffering from linear psoriasis along lines of Blaschko Get access S. Rott, S. Rott Psoriasis Center at the Department of Dermatology, University of Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany *Department of Paediatric Rheumatology, Rheumaklinik Bad Bramstedt, Bad Bramstedt, Germany E‐mail: srott@dermatology.uni‐kiel.de Search for other works by this author on: Oxford Academic Google Scholar R.M. Küster, R.M. Küster Psoriasis Center at the Department of Dermatology, University of Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany *Department of Paediatric Rheumatology, Rheumaklinik Bad Bramstedt, Bad Bramstedt, Germany E‐mail: srott@dermatology.uni‐kiel.de Search for other works by this author on: Oxford Academic Google Scholar U. Mrowietz U. Mrowietz Psoriasis Center at the Department of Dermatology, University of Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany *Department of Paediatric Rheumatology, Rheumaklinik Bad Bramstedt, Bad Bramstedt, Germany E‐mail: srott@dermatology.uni‐kiel.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 1, 1 July 2007, Pages 191–192, https://doi.org/10.1111/j.1365-2133.2007.07928.x Published: 01 July 2007
Adaptive boundary dependent transform optimization for HEVC (2015)

High Efficiency Video Coding (HEVC) adopts hybrid transform coding scheme to improve the transform performance. However, it does not consider the influence of the prediction unit boundary. This paper proposes an adaptive boundary dependent transform optimization scheme for HEVC. Based on the transform unit boundary type identification by checking whether it lies at a prediction unit boundary or not, some additional transform kernels, including DCT-IV, are incorporated for transform. Moreover, the additional adopted transform kernels are generated by re-using the existing kernels in HEVC. Therefore, the butterfly structure for transform implementation can be preserved to facilitate parallel computing, and computational complexity increasing can be avoided. Experimental results show that the coding performance improvements can be up to 0.96% and 0.64% for low delay P and random access testing configurations respectively.
Design, synthesis, docking and in vitro antifungal study of 1,2,4-triazole hybrids of 2-(aryloxy)quinolines (2017)

Abstract Substituted quinolines containing a 1,2,4-triazole moiety were synthesized using reported methods. The molecular docking studies support the experimental results that these compounds are active against A. fumigatus and C. albicans where N -myristoyl transferase (NMT) and dihydrofolate reductase (DHFR), respectively, are the target enzymes. The analogues that contain methoxy and chloro substituents exhibit the best antifungal activity.