gebhart/patrepeval huggingface dataset:
Monitoring technology to enable characterization of CCUS reservoirs (2022)

Surveillance monitoring technology enables effective injection projects by accurately capturing the physical properties of the subsurface that impact injection. Without proper monitoring and planning, fluid injection into the subsurface can lead to adverse effects, including fault reactivation or microseismic events, out of zone injection, or even fracturing into the overburden. Subsurface data enables model calibration and inclusion of complexity that can accurately explain and constrain these multifaceted systems, helping to design reliable storage systems for CO2 injection. A range of surveillance technologies are needed to adequately monitor the subsurface for proper characterization of the effectiveness of long-term storage in CCUS reservoirs and deliver innovations for increasing efficiency. As learnings are captured and innovations grow, utilization of the surveillance technologies will evolve and possibly be more selective. Core measurements of depletion and injection cycles are needed to build models that accurately represent hysteresis or plastic deformation. Enhanced physical property models improve the understanding of the potential to inject into a reservoir without any adverse subsurface effects. Data from Interferometric Synthetic Aperture Radar (InSAR) and Pressure Monitor Transponders (PMTs) are useful to constrain model deformation and to identify deformation due to out of zone injection and fault reactivation. Microseismic is critical for monitoring injection in fractured and faulted fields. 4D seismic can be used to monitor CO2 plume migration, but it is also useful for identifying strain responses associated with overburden fracturing and fault reactivation. Electromagnetic data can also be used to understand out of zone injection. Wellbore monitoring, including DAS/DTS/DSS/DPS, helps to understand cement integrity and long-term storage viability. CO2 leak detection technology at the wellbore and the field scale ensures reliability of the system. The gamut of surveillance technologies enables perspectives from the well scale to the regional scale and helps to uncover the subsurface complexities that inhibit efficiency and storage capacity.
Operation of the CO Dehydrogenase/Acetyl Coenzyme A Pathway in both Acetate Oxidation and Acetate Formation by the Syntrophically Acetate-Oxidizing Bacterium Thermacetogenium phaeum (2005)

Thermacetogenium phaeum is a homoacetogenic bacterium that can grow on various substrates, such as pyruvate, methanol, or H2/CO2. It can also grow on acetate if cocultured with the hydrogen-consuming methanogenic partner Methanothermobacter thermautotrophicus. Enzyme activities of the CO dehydrogenase/acetyl coenzyme A (CoA) pathway (CO dehydrogenase, formate dehydrogenase, formyl tetrahydrofolate synthase, methylene tetrahydrofolate dehydrogenase) were detected in cell extracts of pure cultures and of syntrophic cocultures. Mixed cell suspensions of T. phaeum and M. thermautotrophicus oxidized acetate rapidly and produced acetate after addition of H2/CO2 after a short time lag. CO dehydrogenase activity staining after native polyacrylamide gel electrophoresis exhibited three oxygen-labile bands which were identical in pure culture and coculture. Protein profiles of T. phaeum cells after sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that the strain exhibited basically the same protein patterns in both pure and syntrophic culture. These results indicate that T. phaeum operates the CO dehydrogenase/acetyl-CoA pathway reversibly both in acetate oxidation and in reductive acetogenesis by using the same biochemical apparatus, although it has to couple this pathway to ATP synthesis in different ways.
Identification of lncRNAs regulating variable stress-responding sheep naturally exposed to gastrointestinal nematode parasites (2019)

Better insight into the genetics of the ovine host response to gastrointestinal nematode parasites will enable improvement in integrated management strategies. Little is known about long noncoding RNA (lncRNA) function in the host response to nematodes infection. Samples from sheep naturally exposed to Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus gastrointestinal nematodes with High (n = 5) and Moderate (n = 5) cortisol responses, and non-exposed Controls (n = 4) were used to characterize lncRNA changes in liver using RNA-Seq. Samples were aligned to the sheep reference genome (Oar_v.3.1) using STAR software. Cufflinks and Stringtie software were used to construct 2 novel transcript models. FEELnc was used to identify lncRNAs in both approaches obtaining 3,688 and 4,854 lncRNAs with Cufflinks and Stringtie, respectively. The sensitivity and specificity for the lncRNA detection were 0.92. The coding potential threshold used to determine if a transcript was characterized as mRNA or lncRNA was 0.42. Among them, 3,307 lncRNAs were shared between the 2 transcript sets. When lncRNA models from the 2 assembly approaches and those shared among methodologies were compared with known sheep lncRNAs, those detected by both assemblers had the highest sensitivity (0.89) and precision (0.54) at the locus level. Common lncRNAs were used for further differential expression (DE) analyses between Control sheep and High and Moderate stress responders. The estimation of reads per lncRNA and DE analyses were performed using RSEM and DESeq2 software. A total of one, 16 and 23 DE lncRNAs were identified between High vs. Moderate, High vs. Control and Moderate vs. Control groups, respectively. Functional analyses performed using the list of genes located in close proximity (0.01–1 Mb window) to the lncRNAs suggested that regulation of steroid metabolism or oxidoreductase activity may influence the different responses to parasites in High and Moderate stress responder sheep. These results indicate that lncRNAs may be used as potential targets or indicators to control for gastrointestinal nematode parasites in sheep.
188Re-ZHER2:V2, a Promising Affibody-Based Targeting Agent Against HER2-Expressing Tumors: Preclinical Assessment (2014)

(188)Re-ZHER2:V2 can deliver high absorbed doses to tumors without exceeding kidney and bone marrow toxicity limits.
Interaction of hydroperoxopalladium complexes, (TpR)(py)Pd–OOH, with hydroxo-nickel and -cobalt complexes, [(μ-OH)(MTpR′)]2(M = Ni, Co), leading to oxidative dehydrogenation of the saturated hydrocarbyl moiety in the ancillary ligand (TpiPr2) (2003)

Treatment of hydroperoxopalladium complexes, (TpR)(py)Pd–OOH, with hydroxonickel complexes, [(μ-OH)NiTpR′]2, when either TpR or TpR′ is TpiPr2, results in dehydrogenation of an isopropyl group of the TpiPr2 ligand to give heterobimetallic di-μ-hydroxo complexes bearing the 3-isopropenyl-substituted Tp ligand [HB(pziPr2)2(pz3-isopropenyl-5-iPr). Similar dehydrogenation is observed for the reaction with the hydroxocobalt complex bearing the TpiPr2 ligand. The dehydrogenated products are characterized by spectroscopic and crystallographic methods and a mechanism involving a heterobimetallic μ-peroxo intermediate formed via dehydrative condensation has been proposed for the oxidative dehydrogenation.
Modular multilevel converter modeling for power system studies (2013)

This paper presents two modular multilevel converter model versions that could be used for power system studies, with slow dynamics. Additionally, the interfacing of the presented models with the control systems is been demonstrated when both models are used to simulate an HVDC converter station that operates in an inversion mode. The presented models have been validated against a detail modular converter model with 16 cells per arm (the same power rating and control systems). It is shown that the presented models are able to match the results obtained from a detail switch model of the modular converter. This includes active and reactive power manipulation, and voltage and current waveforms. Further results that illustrate the potential use of a modular converter dq model in small signal stability are also presented. This paper also presented detailed design of the current controller, taking into account the internal parameters of the modular converter.
Clinical laboratory mutation analysis performed on aggressive B cell non-Hodgkin lymphoma patient biopsies. (2022)

e19561 Background: Results from comprehensive genomic analysis performed on aggressive B cell non-Hodgkin lymphomas (aBNHL) patient (pt) biopsies (bx) have identified mutations (mut) which may be predictive of pt survival. However, results from mut analysis (MA) performed on aBNHL pt bx in clinical laboratories are not well-described. Methods: Bx diagnostic of non-Burkitt aBNHL obtained from 7/2015-2/2021 with MA performed in the Penn Center for Personalized Diagnostics clinical laboratory using 3 consecutive versions of lymphoma sequencing panels were retrospectively analyzed. Mut tested varied by panel. Mut detected with variant allele frequency (VAF) ≥10% were included. Results: MA was performed on 293 aBNHL pt bx with a successful assay for 270 (7.8% failure rate). Request for MA was made by interpreting hematopathologist 93% and treating clinician 7%. Median turnaround time (TAT) from receipt of bx to result report was 18 (range 8-53) days. Notable pt characteristics included prior/concurrent indolent lymphoma (IL) 31% and prior systemic therapy received for IL and/or aBNHL 38%. Notable bx characteristics included bx type paraffin-embedded tissue 85% and bone marrow 12%, histologic classification diffuse large B cell lymphoma 86% and high grade B cell lymphoma 13%, cell of origin (COO) by Hans algorithm non-germinal center B (non-GCB) 51% and GCB 44%, known double expressor lymphoma 30%, known MYC rearrangement 18%, known double hit lymphoma 9% and any mut detected with VAF ≥10% 82%. Number and percentage of mut occurring in ≥10% of bx (minimum tested bx for mut ≥92) with associated COO are listed in the table. Subset analysis of 147 bx obtained from pts with newly-diagnosed aBNHL (15% with previously-untreated IL) had similar bx characteristics to the entire population were analyzed for the presence of mut reported in poor-prognosis COO-associated classifications: Cluster 5 for non-GCB and Cluster 3 for GCB (PMID: 29713087), double-hit signature (DHITsig) for GCB (PMID: 30523716) and molecular high grade (MHG) for GCB (PMID: 30523719). For 77 non-GCB bx, 19% had Cluster 5 mut. For 59 GCB bx, 56% had at least one of Cluster 3, DHITsig or MHG mut. Conclusions: Clinical laboratory MA performed on nearly 300 aBNHL pt bx was highly successful with a short TAT and demonstrated recurrent gene mut associated with aBNHL development. In the subset of bx from previously-untreated pts, MA identified mut associated with poor-prognosis genetic subtypes of aBNHL.[Table: see text]
Quadruply bonded dimolybdenum compound containing only chelating ligands: bis(diethyl-2-pyrazolylhydroxoborato)bis(diethyldi-2-pyrazolylborato)dimolybdenum (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuadruply bonded dimolybdenum compound containing only chelating ligands: bis(diethyl-2-pyrazolylhydroxoborato)bis(diethyldi-2-pyrazolylborato)dimolybdenumF. Albert Cotton, Brian W. S. Kolthammer, and Graham N. MottCite this: Inorg. Chem. 1981, 20, 11, 3890–3895Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/ic50225a058https://doi.org/10.1021/ic50225a058research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Advances on the Way to a Stationary Hybrid Power Plant (2011)

The demand for electrical energy is&#13;\ngrowing continually. In order to meet&#13;\nthis demand in future power plants&#13;\nwith high efficiency and low emissions&#13;\nare needed such as a hybrid power&#13;\nplant consisting of an SOFC system&#13;\ncombined with a gas turbine which&#13;\noffers electrical efficiencies of up to&#13;\n60% at a wide range of applications&#13;\nfrom kW to MW. One mayor&#13;\nadvantage of this combination is that&#13;\nit can be operated on natural gas&#13;\nfrom the existing grid. Efficiencies&#13;\nhave been shown to be highest if the&#13;\nSOFC subsystem is pressurized. This&#13;\nand the requirements due to the&#13;\ninteraction with the gas turbine lead&#13;\nto a need to exactly understand the&#13;\nbehavior of SOFC at elevated&#13;\npressures. The German Aerospace&#13;\nCenter (DLR) is aiming to demonstrate&#13;\nstable operation of such a hybrid&#13;\npower plant and is currently&#13;\nexamining the behavior, requirements&#13;\nand limits of the subsystems.
Compact Architecture For Spectrum Analysis And Correlation (1984)

An acousto-optic architecture for simultaneously obtaining time integration correlation and high-speed power spectrum analysis has been constructed using commercially available Te02 modulators and photodiode detector-arrays. The correlator section of the processor uses coherent interferometry to attain maximum bandwidth and dynamic range while achieving a time-bandwidth product of 106. Two correlator outputs are achieved in this system configuration. One is optically filtered and magnified 2 : 1 to decrease the spatial frequency to a level where a 25-MHz bandwidth may be sampled by a 62-mm array with elements on 25-&mu;m centers. The other output is magnified by a factor of 10 such that the center 4 &mu;S of information is available for estimation of time-difference-of-arrival to within 10 ns. The Bragg cell spectrum-analyzer section, which also has two outputs, resolves a 25-MHz instantaneous bandwidth to 25 kHz and can determine discrete-frequency reception time to within 15 &mu;s. A microprocessor combines spectrum analysis information with that obtained from the correlator.
Exercise has a Disproportionate Role in the Pathogenesis of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy in Patients Without Desmosomal Mutations (2014)

Gene‐elusive, non‐familial ARVD/C is associated with very high intensity exercise suggesting exercise has a disproportionate role in the pathogenesis of these cases. As exercise negatively modifies cardiac structure and promotes arrhythmias, exercise restriction is warranted.
Intestinal microvascular responses to polymicrobial sepsis in prediabetic obese mice (2007)

Sepsis is the leading cause of morbidity and mortality in non‐coronary intensive care units in the United States and has a death rate comparable to that of myocardial infarction. Obesity has been on the rise over the past few decades and currently nearly two thirds of US adults are overweight. There is growing evidence that obese individuals have a significantly higher mortality and complication rates in critically ill patients with sepsis. The objective of this study was to define the microvascular alterations elicited by cecal ligation and puncture (CLP), a model of sepsis, in two different mouse models (ob/ob &amp; db/db) of obesity, compared to their lean counterparts. Intravital video microscopy was used to quantify leukocyte and platelet adhesion in the small bowel in wild type (WT) mice, ob/ob and db/db mice subjected to CLP. CLP (at 6 hrs) caused a significantly increased adhesion of leukocytes and platelets in both ob/ob and db/db mice compared to WT mice. No differences in blood cell adhesion were found in sham animals of all three strains tested. Adiponectin levels were significantly elevated in both sham and septic db/db mice when compared to WT mice. These findings indicate that obesity exaggerates the inflammatory and prothrombogenic phenotype that is assumed by the microvasculature during polymicrobial sepsis (Supported by DK43785).
[Drugs for relief of pain]. (1994)

Currently, the pharmacology of analgesics can be sum up to three main compounds: morphine, paracetamol and aspirin. The use of antidepressants and anticonvulsants will also be mentioned. Morphine remains the reference compound among centrally acting analgesics both for acute and chronic pain. Its mechanism of action is relatively well known as well as the role of opiate receptors. Paracetamol is largely used as analgesic for relief of slight to moderate pain. Its mechanism of action still remains unclear. Usually the tolerability of this compound is considered as being excellent. However overdosage can induce severe and possible lethal liver necrosis. Aspirin is also a very old and a largely used compound. Its inhibiting effect on cyclooxygenase acts mainly peripherally but it could also act centrally. According to the current knowledge of its mechanism of action, it seems that the main pharmacological properties as well as adverse events of aspirin are all related to its enzyme inhibiting effect. Slight to moderate pain, related or not to inflammatory disease responds well to aspirin and other NSAIDs.
A cluster of vitreoretinal lymphoma in New York with possible link to the Chernobyl nuclear disaster (2017)

Vitreoretinal lymphoma (VRL) is an ultra-rare disease and an unusual presentation of primary central nervous system lymphoma (PCNSL) [1]. A quarter of PCNSL patients develop VRL and upto 85% of VRL...
Identification of a novel uterine leiomyoma GWAS locus in a Japanese population (2020)

Uterine leiomyoma is one of the most common gynaecologic benign tumours, but its genetic basis remains largely unknown. Six previous GWAS identified 33 genetic factors in total. Here, we performed a two-staged GWAS using 13,746 cases and 70,316 controls from the Japanese population, followed by a replication analysis using 3,483 cases and 4,795 controls. The analysis identified 9 significant loci, including a novel locus on 12q23.2 (rs17033114, P = 6.12 × 10<sup>-25</sup> with an OR of 1.177 (1.141-1.213), LINC00485). Subgroup analysis indicated that 5 loci (3q26.2, 5p15.33, 10q24.33, 11p15.5, 13q14.11) exhibited a statistically significant effect among multiple leiomyomas, and 2 loci (3q26.2, 10q24.33) exhibited a significant effect among submucous leiomyomas. Pleiotropic analysis indicated that all 9 loci were associated with at least one proliferative disease, suggesting the role of these loci in the common neoplastic pathway. Furthermore, the risk T allele of rs2251795 (3q26.2) was associated with longer telomere length in both normal and tumour tissues. Our findings elucidated the significance of genetic factors in the pathogenesis of leiomyoma.
Modeling intercellular interactions in the peripheral immune system (2004)

Peripheral tissue microenvironments play an important role in determining responses to infection, but these small-scale interactions are usually not included in immune system models. An immune response to a pathogen involves numerous cells of several different types, each with a limited ability to sense its environment and to act. These cells produce many kinds of signalling molecules called cytokines that act locally to affect cell behavior. The dynamical interactions among this heterogeneous collection of cells and molecules are extremely complex. To begin to understand such a system, we need modeling approaches that can relate population-level dynamics to individual cell interactions and responses to cytokines. This thesis describes a spatially explicit simulator that tracks individual cell responses to local molecular signals, and the use of that simulator to study models of peripheral tissue dynamics in normal and disease conditions. 
The simulator implements a hybrid framework combining discrete representation of individual cells and continuous representation of molecular concentrations. Cell behaviors consist of sensing, intracellular processing, and action functions that can be combined in various ways to accommodate a variety of models. Connecting extracellular signals to individual cell actions is difficult because intracellular signalling itself is complex and incompletely understood. Many of the processes involved occur on different timescales and stochastic effects may be important. The approach presented here abstracts away much of this intracellular signalling complexity, while capturing the aspects most likely to affect intercellular dynamics. Separation of sensing and processing allows the kind of pleiotropy seen in intercellular systems—each cytokine may affect multiple cell actions, and multiple cytokines may affect a single action. 
The goal of this work is to relate individual cell actions and intercellular interactions to observed population-level dynamics. For concreteness, this study focuses on alveolar lung tissue and the response to Mycobacterium tuberculosis. In the absence of infection, a dynamic population of peripheral immune system effector cells provides a sentinel function. In an effective response to pathogenic challenge, this population expands and changes function to either eliminate the pathogen, or—as in many cases of tuberculosis—isolate it and minimize the effects on surrounding tissues. This requires recruitment and spatial organization of the right kinds of cells and appropriate regulation of their effector functions. The models presented here explore the relative importance of various regulatory mechanisms in effectively controlling a local population of immune cells.