gebhart/patrepeval huggingface dataset:
Hybrid user interfaces (1991)

While virtual worlds offer a compelling alternative to conventional interfaces, the technologies these systems currently use do not provide sufficient resolution and accuracy to support detailed work such as text editing. We describe a pragmatic approach to interface design that provides users with a large virtual world in which such high-resolution work can be performed. Our approach is based on combining heterogeneous display and interaction device technologies to produce a hybrid user interface. Display and interaction technologies that have relatively low resolution, but which cover a wide (visual and interactive) field are used to form an information surround. Display and interaction technologies that have relatively high resolution over a limited visual and interaction
Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. (1994)

Inbred strain C57BL/6J mice develop typical atherosclerotic fatty streaks in the aorta after 15 wk on a high fat, high cholesterol diet. To investigate the effects of the immune system on the development of fatty streaks in this model, C57BL/6J mice with a normal immune system were compared with C57BL/6J mice carrying mutations resulting in various immune deficiencies. These included mice with severe combined immune deficiency, athymic "nude" mice, class I MHC deficient mice, and class II MHC deficient mice. Despite similar lipoprotein profiles, lesion development in the immune compromised strains was similar to or increased compared with normal C57BL/6J mice. Class I MHC deficient mice demonstrated a threefold increase in lesion area (22,961 +/- 6,653 vs 8,868 +/- 1,817 microns2, P = 0.01). Immunohistochemical analysis of lesions showed characteristic features of atherosclerosis with vascular cell adhesion molecule-1 expression, immunoglobulin deposition, monocyte infiltration, and smooth muscle cell proliferation. These data indicate that the classical immune system, while not essential for atherosclerotic fatty streak development, may act to suppress the development of lesions.
Co-expression Analysis to Identify Key Modules and Hub Genes Associated With COVID19 in Platelets (2021)

Abstract The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a highly contagious virus that causes a severe respiratory disease known as Corona virus disease 2019 (COVID19). Indeed, COVID19 increases the risk of cardiovascular occlusive/thrombotic events and is linked to poor outcomes. The pathophysiological processes underlying COVID19-induced thrombosis are complex, and remain poorly understood. To this end, platelets play important roles in regulating our cardiovascular system, including via contributions to coagulation and inflammation. There is an ample of evidence that circulating platelets are activated in COVID19 patients, which is a primary driver of the thrombotic outcome observed in these patients. However, the comprehensive molecular basis of platelet activation in COVID19 disease remains elusive, which warrants more investigation. Hence, we employed gene co-expression network analysis combined with pathways enrichment analysis to further investigate the aforementioned issues. Our study revealed three important gene clusters/modules that were closely related to COVID19. Furthermore, enrichment analysis showed that these three modules were mostly related to platelet metabolism, protein translation, mitochondrial activity, and oxidative phosphorylation, as well as regulation of megakaryocyte differentiation, and apoptosis, suggesting a hyperactivation status of platelets in COVID19. We identified the three hub genes from each of three key modules according to their intramodular connectivity value ranking, namely: COPE, CDC37, CAPNS1, AURKAIP1, LAMTOR2, GABARAP MT-ND1, MT-ND5, and MTRNR2L12. Collectively, our results offer a new and interesting insight into platelet involvement in COVID19 disease at the molecular level, which might aid in defining new targets for treatment of COVID19–induced thrombosis.
Wavelength Coded Image Transmission and Holographic Optical Elements. (1984)

The results of a three year optics research program are described. Research was initially performed on wavelength coded image transmission. The goal of the program was to study various methods and systems for encoding object information in a wavelength multiplexed form so that the various wavelengths could be transmitted through a non-imaging media such as fog or a fiber optic and later spatially repositioned to reassemble an image of the original object. Such a system could be used to transmit image information at higher data rates and/or to transmit images through fewer optical channels. During the second year, the program was augmented to include research on a new type of holographic optical element called a multifact hologram,. Such holograms consist of a large number of small, adjacent holograms (facets) which collectively diffract light to produce a desired output. These elements share some of the flexibility advantageous to Computer Generated Holograms with the high optical efficiency inherent in interferometrically recorded volume holograms. A computer controlled recording system was built to fabricate these elements. A number of space-variant image operations not possible with conventional optics were demonstrated using multi-facet holograms. (Author)
Studies on positive inotropic agents. II. Synthesis of (4-substituted 1-piperazinylcarbonyl)-2-(1H)-quinolinone derivatives. (1986)

Many (1-piperazinylcarbonyl)-2(1H)-quinolinone derivatives were synthesized and examined for positive inotropic activity on the canine heart. Among them, 3, 4-dihydro-6-[4-(3-oxo-3-phenylpropyl)-1-piperazinylcarbonyl]-2(1H)-quinolinone (XXIj) and 3, 4-dihydro-6-[4-(oxo-4-phenylbutyl)-1-piperazinylcarbonyl]-2(1H)-quinolinone (XXIl) were found to have potent activity.
Theoretical studies of UV-preionized transverse discharge KrF and ArF lasers (1978)

A theoretical model has been developed to examine the behavior of UV preionized, fast transverse discharge, rare-gas halide lasers. The model integrates the time dependent circuit equations for the discharge, the kinetic equations for the important atomic and molecular species and electrons, and the equations describing the growth of the spontaneous and stimulated emission. Results of KrF and ArF are compared with those in a companion experimental paper by Sze and Loree. The effects of various self-absorption mechanisms in the laser media are discussed, along with the possible impact of several uncertainties regarding the fundamental processes occurring in such lasers.
Semantic Annotation of Predictive Modelling Experiments (2020)

Abstract In this paper, we address the task of representation, semantic annotation, storage, and querying of predictive modelling experiments. We introduce OntoExp, an OntoDM module which gives a more granular representation of a predictive modeling experiment and enables annotation of the experiment’s provenance, algorithm implementations, parameter settings and output metrics. This module is incorporated in SemanticHub, an online system that allows execution, annotation, storage and querying of predictive modeling experiments. The system offers two different user scenarios. The users can either define their own experiment and execute it, or they can browse the repository of completed experimental workflows across different predictive modelling tasks. Here, we showcase the capabilities of the system with executing multi-target regression experiment on a water quality prediction dataset using the Clus software. The system and created repositories are evaluated based on the FAIR data stewardship guidelines. The evaluation shows that OntoExp and SemanticHub provide the infrastructure needed for semantic annotation, execution, storage, and querying of the experiments.
Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response. (1989)

Cell-substratum adhesion strengths have been quantified using fibroblasts and glioma cells binding to two extracellular matrix proteins, fibronectin and tenascin. A centrifugal force-based adhesion assay was used for the adhesive strength measurements, and the corresponding morphology of the adhesions was visualized by interference reflection microscopy. The initial adhesions as measured at 4 degrees C were on the order of 10(-5)dynes/cell and did not involve the cytoskeleton. Adhesion to fibronectin after 15 min at 37 degrees C were more than an order of magnitude stronger; the strengthening response required cytoskeletal involvement. By contrast to the marked strengthening of adhesion to FN, adhesion to TN was unchanged or weakened after 15 min at 37 degrees C. The absolute strength of adhesion achieved varied according to protein and cell type. When a mixed substratum of fibronectin and tenascin was tested, the presence of tenascin was found to reduce the level of the strengthening of cell adhesion normally observed at 37 degrees C on a substratum of fibronectin alone. Parallel analysis of corresponding interference reflection micrographs showed that differences in the area of cell surface within 10-15 nm of the substratum correlated closely with each of the changes in adhesion observed: after incubation for 15 min on fibronectin at 37 degrees C, glioma cells increased their surface area within close contact to the substrate by integral to 125-fold. Cells on tenascin did not increase their surface area of contact. The increased surface area of contact and the inhibitory activity of cytochalasin b suggest that the adhesive "strengthening" in the 15 min after initial binding brings additional adhesion molecules into the adhesive site and couples the actin cytoskeleton to the adhesion complex.
Viscoelastic Properties of Comb-Shaped Polystyrenes (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTViscoelastic Properties of Comb-Shaped PolystyrenesTeruo Fujimoto, Hiroshi Narukawa, and Mitsuru NagasawaCite this: Macromolecules 1970, 3, 1, 57–64Publication Date (Print):January 1, 1970Publication History Published online1 May 2002Published inissue 1 January 1970https://pubs.acs.org/doi/10.1021/ma60013a013https://doi.org/10.1021/ma60013a013research-articleACS PublicationsRequest reuse permissionsArticle Views229Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A feedback regulatory pathway between LDL and alpha-1 proteinase inhibitor in chronic inflammation and infection. (2013)

Dietary lipids are transported via lymph to the liver and transformed to lipoproteins which bind to members of the low density lipoprotein receptor family (LDL-RFMs). Certain LDL-RFMs, e.g., very low density lipoprotein receptor (VLDLR), are also bound by inactivated proteinase inhibitors, the most abundant being α1proteinase inhibitor (α1PI, α1antitrypsin). Inflammation/infection, including HIV-1 infection, is accompanied by low levels of CD4+ T cells and active α1PI and high levels of inactivated α1PI. By inducing LDL-RFMs-mediated cellular locomotion, active α1PI regulates the number of CD4+ T cells. We sought to investigate whether CD4+ T cells and α1PI directly impact lipoprotein levels. At the cellular level, we show that active α1PI is required for VLDLR-mediated uptake of receptor-associated cargo, specifically CD4-bound HIV-1. We show that active α1PI levels linearly correlate with LDL levels in HIV-1 infected individuals (P<0.001) and that therapeutic, weekly infusions of active α1PI elevate the number of CD4+ T cells and HDL levels while lowering LDL levels in patients on antiretroviral therapy with controlled HIV-1. Based on the unusual combination of lipodystrophy and low levels of α1PI and CD4+ T cells in HIV-1 disease, we reveal that LDL and α1PI participate in a feedback regulatory pathway. We demonstrate integral roles for sequentially acting active and inactive α1PI in the uptake and recycling of receptors and cargo aggregated with VLDLR including CD4 and chemokine receptors. Evidence supports a role for α1PI as a primary sentinel to deploy the immune system as a consequence of its role in lipoprotein transport.
Corrosion and electrochemistry of zinc (1997)

Properties, Products, and Processes. Electrochemical Thermodynamics and Elemental Reactions. Passivation and Surface Film Formation. Semiconductor Electrochemistry of Zinc Oxide. Corrosion Potential and Corrosion Current. Corrosion Products. Corrosion Forms. Atmospheric Corrosion. Corrosion in Water and Aqueous Solutions. Corrosion in Soil. Under Paint Corrosion. Zinc Rich Coating. Corrosion in Concrete. Corrosion in Batteries. Corrosion in other Environments. Index.
Sequencing radium 223 (RA223) for metastatic castration-resistant prostate cancer (mCRPC) patients (pts) in the daily practice: Preliminary results from a retrospective study in Italian centers. (2018)

322 Background: The potential advantage of the sequential use of the active drugs (ADs) able to prolong overall survival (OS) in mCRPC (abiraterone, cabazitaxel, docetaxel, enzalutamide, RA223) could be limited by the development of common mechanisms of resistance. According to its unique targeted alpha-radiation mechanism of action, it could be postulated that RA223 does not induce and is not affected by cross-resistance with other agents and consequently its incorporation in therapeutic sequences may improve clinical outcomes. The present study is aimed to describe the clinical outcomes of pts who received RA223 and at least two other ADs for mCRPC. Methods: We collected data of pts who received sequentially 3 or more ADs of which one was RA223. For each pt we recorded the clinical outcome of all treatments received for mCRPC. We also compared the cumulative survival from the start of the first line to that of a contemporary series of 405 mCRPC pts without visceral mets sequentially treated with 3 or 4 ADs not comprising RA223. Results: A consecutive series of 119 mCRPC pts was collected: the median age was 72 yrs. Six pts received all 5 available ADs, 53 pts 4 ADs, and the remaining pts 3 ADs. Most of the pts received RA223 as the 3 rd or 4 th line of treatment (62 and 42, respectively), and the remaining were treated in less or more advanced lines (10 and 5 pts respectively). Overall the full 6-cycle treatment was completed in 61 pts (51.3%) and in 61.3% and 38.1% of pts when Ra223 was administered as 3 rd and 4 th treatment line respectively (p = 0.02). Partial response and stable disease as best objective response to RA223 was achieved in 11.3% and 24.5% of pts respectively, while a PSA reduction of ≥ 50% was observed in 7.2% of pts. Median OS from the start of the first line was 48 mos. In pts treated with 3 or 4 ADs that included Ra223, the median OS was significantly longer compared to that of pts whose treatment sequence did not include RA223 (48.4 vs 39.2 mos, p = 0.03). Conclusions: Despite the limitations of its retrospective nature, this preliminary data suggests that treatment sequencing of ADs that includes RA223 offers a survival advantage in mCRPC.
Crowdsourced Multi-View Live Video Streaming using Cloud Computing (2017)

Advances and commoditization of media generation devices enable capturing and sharing of any special event by multiple attendees. We propose a novel system to collect individual video streams (views) captured for the same event by multiple attendees, and combine them into multi-view videos, where viewers can watch the event from various angles, taking crowdsourced media streaming to a new immersive level. The proposed system is called Cloud-based Multi-View Crowd sourced Streaming (CMVCS), and it delivers multiple views of an event to viewers at the best possible video representation based on each viewer's available bandwidth. The CMVCS is a complex system having many research challenges. In this paper, we focus on resource allocation of the CMVCS system. The objective of the study is to maximize the overall viewer satisfaction by allocating available resources to transcode views in an optimal set of representations, subject to computational and bandwidth constraints. We choose the video representation set to maximize QoE using Mixed Integer Programming. Moreover, we propose a Fairness-Based Representation Selection (FBRS) heuristic algorithm to solve the resource allocation problem efficiently. We compare our results with optimal and Top-N strategies. The simulation results demonstrate that FBRS generates near optimal results and outperforms the state-of-the-art Top-N policy, which is used by a large-scale system (Twitch).
A Class-Based Feature Selection Method for Ensemble Systems (2008)

Diversity is considered as one of the main prerequisites for an efficient use of ensemble systems. One way of increasing diversity is through the use of feature selection methods in ensemble systems. In this paper, a class-based feature selection method for ensemble systems is proposed. The proposed method is inserted into the filter approach of feature selection methods and it chooses only the attributes that are important only for a specific class. An analysis of the performance of the proposed method is also investigated in this paper and it shows that the proposed method has outperformed the standard feature selection method.
Coordinate regulation of heterogeneous nuclear ribonucleoprotein dynamics by steroid hormones in the human fallopian tube and endometrium in vivo and in vitro (2012)

Heterogeneous nuclear ribonucleoproteins (hnRNPs), which are chromatin-associated RNA-binding proteins, participate in mRNA stability, transport, intracellular localization, and translation by acting as transacting factors. Several studies have shown that steroid hormones can regulate hnRNP expression. However, to date, the regulation of hnRNPs and their interactions with steroid hormone signaling in fallopian tubes and endometrium are not fully elucidated. In the present study, we determined whether hnRNP expression is regulated during the menstrual cycle and correlates with estrogen receptor (ER) and progesterone receptor (PR) levels in human fallopian tubes in vivo. Because of the limited availability of human tubal tissues for the research, we also explored the mechanisms of hnRNP regulation in human endometrium in vitro. Fallopian tissue was obtained from patients in the early, late, and postovulatory phases and the midsecretory phase and endometrial tissue from premenopausal and postmenopausal women undergoing hysterectomy. We measured expression of hnRNPs and assessed their intracellular localization and interactions with ERs and PRs. We also determined the effects of human chorionic gonadotropin, 17β-estradiol (E(2)), and progesterone (P(4)) on hnRNP expression. In fallopian tubes, mRNA and protein levels of hnRNP A1, AB, D, G, H, and U changed dynamically during ovulation and in the midsecretory phase. In coimmunolocation and coimmunoprecipitation experiments, hnRNPs interacted with each other and with ERs and PRs in fallopian tubes. After treatment with E(2) and/or P(4) to activate ERs and PRs, hnRNP A1, AB, D, G, and U proteins displayed overlapping but distinct patterns of regulation in the endometrium in vitro. Our findings expand the physiological repertoire of hnRNPs in human fallopian tubes and endometrium and suggest that steroid hormones regulate different hnRNPs directly by interacting with ERs and/or PRs or indirectly by binding other hnRNPs. Both actions may contribute to regulation of gene transcription.
An algorithm to adjust a rigid CT-SPECT fusion so as to maximize tumor counts from CT VoI in I-131 therapies (2005)

The accuracy of the estimate of tumor I-131 activity in therapy patients using CT-SPECT fusion is difficult to establish. In our work, we have had the impression that a tumor volume of interest (VoI) from CT sometimes does not perfectly overlay the true position of the tumor in the SPECT image set. However, the magnitude of the difference between the activity estimate from the procedure and that from a perfect overlay is uncertain. Although we have not estimated that magnitude, we have investigated how much the activity estimate increases if we apply a last variation on the fusion to change the location of the tumor VoI so as to increase tumor counts. The results show that the algorithm can be effective in registering tumors in CT and SPECT locally as proved by visual checks of the optimized location of the tumor VoI in SPECT. For 14 tumors in seven patients the increases in tumor counts average 6.65%. The maximum increase is 26.7%.
Evaluation of wound healing process based on texture analysis (2015)

The proposed work is to study a standardized and ob jective technique to assess the progress of wound h ealing in foot by means of texture analysis. The methods of i mage pre-processing, segmentation and texture analy sis together with visual expert’s evaluation were used to assess the wound healing process. The images were intensi ty normalized, and wounds were automatic segmented usi ng a snake’s segmentation system. We found texture characteristics that may indicate the progression o f wound healing process. More specifically, some te xture features increase (mean, contrast), while some other texture features decrease (entropy, sum of squares varianc e, sum average, sum variance) with the progression of the wound healing process. Some of these features were found to be significantly different in a specific time point and this could be used to indicate the rate of wound healing. No significant differences were found for all geometri cal measures. The results of this study suggest tha t some texture features might be used to monitor the wound healing process, thus reducing the workload of experts, pr ovide standardization, reduce costs, and improve the qual ity for patients. The simplicity of the method also suggests that it may be a valuable tool in clinical wound evaluation .
Design of the Traveling-Wave Series-Fed Microstrip Antenna Array with Power Control Slits of Unequal Inter-Element Spacing (2020)

This study aims to propose a novel traveling-wave series-fed microstrip array antenna and its design. The proposed antenna has two features: additional slits placed on the output side of the antenna element are introduced as a new degree of freedom to control the radiation power from each element. Also, the unequal element spacing is applied to compensate passing phases of each antenna element; meander lines that would increase the insertion loss are not used. A 9-element linear array is designed and tested, and the simulated and measured results agree, thus validating the proposed design.