gebhart/patrepeval huggingface dataset:
Molecular Design for Single-molecule Magnetism of Lanthanide Complexes (2016)

This review highlights the effective design criteria for lanthanide single-molecule magnets, which show strong magnetic blocking temperature up to 60 K. Increase in the anisotropy barrier and decrease in the quantum magnetization are attainable by controlling the ligand field, local molecular symmetry related to the coordination geometry of the complex, and magnetic dipole–dipole interactions between the lanthanide ions. With recent advances in this field, a new 2-coordinate complex, which is predicted to show a blocking temperature of more than 77 K, is also introduced. The existence of a proton in the nitrogen atom of porphyrin ligands quenches the single-molecule magnet because of the destruction of the symmetry, which can be possibly overlooked because of the disorder of the position of the proton in the crystals.
IoT Application Protocols Optimisation for Future Integrated M2M-Satellite Networks (2018)

Satellites are playing a key role in driving the vision for a truly connected world, providing ubiquitous coverage and reliability in places where no other terrestrial technology could. While the potentials of satellites for Internet of Things (IoT) are well recognised, to allow a smooth integration of Machine-toMachine (M2M) and satellite networks, a lot of tweaking and optimising is still required. The M2MSAT project, funded by the European space Agency (ESA) is contributing to fill this gap, investigating optimisations for Message Queuing Telemetry Transport (MQTT) and Constrained Application Protocol (CoAP), identified as IoT Application Protocols suitable for IoT data collection over satellite. This work outlines the efficient configuration of MQTT and CoAP in an integrated M2MSatellite network, and presents some optimisations, designed taking into account the peculiarities of satellite links.
Integrating Real World Experience Into A College Curriculum Using A Multidisciplinary Design Minor (2020)

The real world offers tremendous challenges and numerous opportunities for our engineering students after they complete their formal undergraduate education. Many of these challenges are intrinsically multidisciplinary and require work across the boundaries of traditional educational programs. Too often engineering programs fail to mirror this reality, but instead stovepipe student experiences along disciplinary boundaries (often excluding non-engineers entirely) and fail to provide the touchstone of reality that comes from actually implementing a design.
The 14 C‐urea breath‐test for the detection of gastric Campylobacter pylori infection (for editorial comment, see page 426; see also page 431) (1989)

A breath-test has been developed for the detection of gastric infection with Campylobacter pylori. Urea that is labelled with carbon 14 is administered to a fasting patient and the patient's breath is sampled for radioactivity over the following 30 minutes. If C. pylori is present in the patient's stomach, urease activity causes hydrolysis of the urea and the 14C is absorbed as carbon dioxide. This carbon dioxide enters the patient's bicarbonate pool and eventually is excreted in the breath. The results are expressed as a percentage of the administered dose/mmol carbon dioxide x kg body weight. Sixty-three patients who were undergoing endoscopy were studied. The radioactivity in exhaled breath which was sampled within five minutes of 14C-urea administration was attributed to the presence of urease enzyme in mouth organisms and was discounted. The time-radioactivity curves for breath samples from five to 30 minutes after the administration of 14C-urea gave an excellent separation between subjects with negative results of the examination of gastric-biopsy samples and patients with microbiological and histological evidence of infection with C. pylori. The area under the time-radioactivity curve at between five and 30 minutes after the administration of 14C-urea in 24 patients with negative microbiological results was 6.9 +/- 4.4 area units; in 35 of 39 patients with positive microbiological results, this area was greater than 40 area units. Measured against the results of the microbiological examination of gastric-biopsy samples, the sensitivity of breath-testing was 90% and the specificity was 100%. Measured against the results of histological examination for the presence of C. pylori infection, breath-testing had a sensitivity of 94% and a specificity of 93%. A positive breath-test result also correlated well (P = 0.0001) with the serological antibody test-result. The role of non-invasive tests--enzyme-linked immunosorbent assays and 14C-urea breath-testing--in the management of gastritis and peptic ulcer disease is discussed. We consider that the 14C-urea breath-test has an important role in the noninvasive confirmation of gastric infection with C. pylori and in the follow-up of patients after treatment.
Supplementary Figure 2 from Cofilin Drives Cell-Invasive and Metastatic Responses to TGF-β in Prostate Cancer (2023)

&lt;p&gt;PDF file - 41KB, TGF-β leads to cofilin dephsphorylation and activation (via regulating RhoA) in human LNCaP TβRII prostate cancer cells.&lt;/p&gt;
Secure and QoS-Managed Information Exchange Between Enterprise and Constrained Environments (2014)

Mobile devices performing mission-critical functions at the tactical edge, such as those employed by first responders, military personnel, and law enforcement, operate in environments that are vastly different from enterprise computing environments. In spite of the differences in resource availability, threat models, vulnerabilities, information formats, and communication protocols, there is a great advantage to (and great demand for) enabling information exchange between the tactical edge and enterprise environments. Creating a specialized mobile version of each desired service that incorporates an appropriate level of security protection and quality of service (QoS) for the tactical users is one possibility. Such an approach is not cost effective, however, as the market for a given tactical application is small compared to the commercial user base for mobile applications and services. Furthermore, the need for information or services from the enterprise by tactical users can be too ad hoc and time critical, e.g., during disaster response, to support developing a specialized version. Finally, service specialization for mobile web access covers only one of multiple information dissemination and access patterns that arise in tactical operations. This paper presents the design and a prototype implementation of a gateway solution that provides secure tactical-enterprise information exchange and handles the differences in resource availability, QoS requirements, communication formats, and protocols.
Synthesis and antitumor activity of 4'-O-methyldaunorubicin, 4'-O-methyladriamycin, and their 4'-epi analogs (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antitumor activity of 4'-O-methyldaunorubicin, 4'-O-methyladriamycin, and their 4'-epi analogsG. Cassinelli, D. Ruggieri, and F. ArcamoneCite this: J. Med. Chem. 1979, 22, 2, 121–123Publication Date (Print):February 1, 1979Publication History Published online1 May 2002Published inissue 1 February 1979https://doi.org/10.1021/jm00188a001RIGHTS & PERMISSIONSArticle Views52Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (316 KB) Get e-Alerts Get e-Alerts
Solution-processed efficient deep-blue fluorescent organic light-emitting diodes based on novel 9,10-diphenyl-anthracene derivatives (2015)

Carbazole substituted 9,10-diphenyl-anthracene derivatives used in deep-blue fluorescence OLED materials with excellent performance.
Calibrating Distributed Camera Networks (2008)

Recent developments in wireless sensor networks have made feasible distributed camera networks, in which cameras and processing nodes may be spread over a wide geographical area, with no centralized processor and limited ability to communicate a large amount of information over long distances. This paper overviews distributed algorithms for the calibration of such camera networks- that is, the automatic estimation of each camera's position, orientation, and focal length. In particular, we discuss a decentralized method for obtaining the vision graph for a distributed camera network, in which each edge of the graph represents two cameras that image a sufficiently large part of the same environment. We next describe a distributed algorithm in which each camera performs a local, robust nonlinear optimization over the camera parameters and scene points of its vision graph neighbors in order to obtain an initial calibration estimate. We then show how a distributed inference algorithm based on belief propagation can refine the initial estimate to be both accurate and globally consistent.
Hidden surface removal for axis-parallel polyhedra (2002)

An efficient, output-sensitive method for computing the visibility map of a set of axis-parallel polyhedra (i.e. polyhedra with their faces and edges parallel to the coordinate axes) as seen from a given viewpoint is introduced. For nonintersecting polyhedra with n edges in total, the algorithm runs in time O((n+k)log n), where k is the complexity of the visibility map. The method can handle cyclic overlap of the polyhedra and perspective views without any problem. For c-oriented polyhedra (with faces and edges in c orientations, for some constant c) the method can be extended to run in the same time bound. The method can be extended even further to deal with intersecting polyhedra with only a slight increase in the time bound.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Pathophysiology of asthma (1998)

Further insight into the inflammatory process of asthma has accumulated during the past few years. New inhalational anaesthetics seem to have a better bronchorelaxant effect, and prophylactic treatment with beta2-agonists and local anaesthetics may also be an alternative. Bronchospasm during anaesthesia appears to be less common now, but persons with asthma should still be considered to be at an increased risk of severe morbidity.
[Functional loss of the transplanted kidney: immunological and non-immunological factors]. (2005)

During the past few years, the short-term graft survival after kidney transplantation has improved dramatically, a phenomenon not paralleled by an increase in the long-term graft survival. This is due to the progressive renal injury and dysfunction known as chronic transplant nephropathy or 'chronic rejection', a process that involves both immune and non-immune factors. Immunological factors include T- and B-cell recognition of alloantigens, cytomegalovirus infection, and endothelial cell activation followed by vascular smooth cells proliferation. Among nonimmune mechanisms, proteinuria and hypertension play a relevant role. Moreover, the reduced number of functioning nephrons may trigger an inflammatory process that, eventually, contributes to the loss of the graft. Several studies have documented the efficacy of blocking the renin-angiotensin system (RAS) in reducing proteinuria and preventing renal function deterioration in experimental models of chronic rejection. Early results are promising. However, available clinical trials are rather limited in terms of number of patients enrolled, consequently they cannot be considered definitive. Since several pathogenetic factors are involved in the progression of chronic transplant nephropathy, a multidrug approach with specific immunosuppressants and RAS-blocking drugs has been proposed to control/prevent chronic injury and progressive renal deterioration. Preliminary results in experimental models are promising. Data from prospective clinical trials are, however, mandatory to confirm the efficacy of a polypharmacological strategy in preventing chronic rejection.
Early identification of patients with or at risk of acute lung injury. (2009)

Acute lung injury (ALI ) and its more severe form, acute respiratory distress syndrome (ARDS ), are important critical care syndromes for which the treatment options are limited once the condition is fully established. Enormous basic and clinical research efforts have led to improvements in supportive treatment, but surprisingly little has been done on the prevention of this devastating syndrome. The development and progression of ALI /ARDS may be triggered by various intrahospital exposures including but not limited to transfusion, aspiration, mechanical ventilation, certain medications and delayed treatment of shock and infection. Early recognition of patients with or at risk of ALI /ARDS is essential for designing novel prevention and treatment strategies. Automated electronic screening tools and novel scoring systems applied at the time of hospital admission may facilitate enrollment of patients into mechanistic and outcome studies, as well as future ALI /ARDS prevention trials.
Image segmentation algorithm based on feature fusion and cluster (2011)

In order to make balance between the effect and time consumption of image segmentation, an image segmentation algorithm based on feature fusion and cluster is proposed in this paper. Firstly, the segmentation granularity is obtained adaptively according to the coarseness of image; secondly, different features are extracted, multi features are fused and classified by K-means clustering, and the image can be segmented quickly. Experiments show that the proposed algorithm can segment image quickly, and the segmentation effect is good, which has verified the validity.
A novel transformer winding for phase shift full bridge converter (2009)

A phase-shift full-bridge (PSFB) converter with additional resonant inductor and clamping diodes is attractive topology in high power applications. The additional resonant inductor is used for improving zero voltage switching (ZVS) range and clamping voltage oscillation of the secondary rectifiers. However, since the high input voltage with small duty ratio is applied to the additional resonant inductor, it has very fast flux swing As a result, high eddy current loss and excess eddy current loss are occurred on magnetic core. To overcome this drawback, a new separated resonant inductor winding (SRW) is proposed. It can implement the additional resonant inductor and transformer using only one magnetic. Therefore, it can reduce the size, cost and core loss due to the additional resonant inductor. The experimental results shows that the proposed winding method can achieve high efficiency and high power density in a 1200 W (12 V,100 A) prototype converter.
Polarisation of a T-helper cell immune response by activation of dendritic cells with CpG-containing oligonucleotides: a potential therapeutic regime for bladder cancer immunotherapy (2003)

Intravesical bacillus Calmette-Guerin (BCG) is a treatment for transitional cell carcinoma (TCC) and carcinoma in situ (cis) of the urinary bladder, but some patients remain refractory. The mechanism of cancer clearance is not known, but T cells are thought to play a contributory role. Tissue dendritic cells (DCs) are known to initiate antigen-specific immune responses following activation of receptors, which recognise molecular patterns on the surface of microorganisms. A family of these receptors, the toll-like receptors (TLRs), are also crucial for activating DC to produce cytokines that polarise the T-cell response towards a T helper (Th)1 or Th2 phenotype. This study compared the potential of intact BCG to activate DC with that of the defined TLR4 ligand lipopolysaccharide (LPS) and the TLR9 ligand CpG-oligonucleotide. It was found that all three stimuli efficiently activated normal DC, but cells expressing a mutant TLR4 responded poorly to stimulation with LPS. Importantly, stimulation with BCG induced both IL-12 and IL-10, suggesting subsequent development of a poorly focused T-cell immune response containing both Th1 and Th2 immune function. By contrast, LPS- and CpG-oligonucleotides induced only IL-12, indicating the potential to produce a Th1 response, which is likely to clear cancer most efficiently. Given the toxicity of LPS, our data suggest that CpG-oligonucleotides may be beneficial for intravesical therapy of bladder cancer.
SHAPE: A Parallelization Tool for Sparse Matrix Computations (1992)

We describe the design, implementation and performance of a Sparse Hybrid Automatic Parallelization Environment (SHAPE). SHAPE partitions and schedules sparse matrix computations for Cholesky factorization with the goal of achieving good performance at low cost, while providing flexibility for use as an experimental tool. It employs efficient parallelization algorithms which reduce the communication cost without adversely affecting the load balance by using a hybrid mixture of column and block partitions. Through several parameters, SHAPE aims for portability across a diverse range of sparse matrix structures and message-passing multiprocessors with different communication cost parameters. We present preliminary timing results on the iPSC/860 and compare the performance of SHAPE with that of a commonly used column-based method. The results show that SHAPE significantly reduces computation time, number of messages, and overall communication time for a variety of test matrices.
Drama (2016)

Abstract Drama is a type of performance characterized by conflict and suspense and generally brought to life through theater. This entry emphasizes drama as a social process and art form, focusing on its origins and development primarily as related to the discipline of communication, with additional references to the disciplines of literature and theater.
Highly Efficient Organic Solar Cells Based on S,N-Heteroacene Non-Fullerene Acceptors (2018)

Two novel non-fullerene acceptors, SN6IC and SN6IC-4F, based on an S,N-heteroacene backbone were designed and synthesized. The cyclopentadiene fragments of commonly used acceptors were replaced with pyrrole rings to improve the electron-donating ability to increase the energy levels of the molecules. Both acceptors match well with the absorption and energy levels of the polymer donor PBDB-T, and PBDB-T:SN6IC-4F-based solar cells showed an excellent power conversion efficiency of 13.2%, with a relatively small VOC loss of 0.54 eV. This study proves that the introduction of a nitrogen atom to replace the sp3-hybridized carbon in the fused ring is very effective for making highly efficient NFAs to further improve the performance of organic solar cells.
Adaptive Learning of Engine Friction Specific Variations by Engine Management System (2005)

&lt;div class="htmlview paragraph"&gt;Several detailed models has been developed to determine the individual influence of vehicle related components on the calculation of the desired idle engine speed or torque estimation within the engine management system. Depending of the complexity of those models, calibration effort can become a challenge to ensure acceptable results towards drivability and emissions within the given limited development time. Capturing deviations over the lifetime are rarely traced within those models.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The aim of this writing is to point out a methodology that is able to simplify existing models and provides a way to include possible variations of components over their lifetime. This approach will be described on calculation of desired idle engine speed and torque estimation for a given engine management concept.&lt;/div&gt;
N -Acylhomoserine Lactones Antagonize Virulence Gene Expression and Quorum Sensing in Staphylococcus aureus (2006)

Many gram-negative bacteria employ N-acylhomoserine lactone (AHL)-mediated quorum sensing to control virulence. To determine whether gram-positive bacteria such as Staphylococcus aureus respond to AHLs, we used a growth-dependent lux reporter fusion. Exposure of S. aureus to different AHLs revealed that 3-oxo-substituted AHLs with C10 to C14 acyl chains inhibited light output and growth in a concentration-dependent manner, while short-chain AHLs had no effect. N-(3-Oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) inhibited the production of exotoxins and cell wall fibronectin-binding proteins but enhanced protein A expression. Since these processes are reciprocally regulated via the S. aureus agr quorum-sensing system, which in turn, is regulated via sar, we examined the effect of AHLs on sarA and agr. At sub-growth-inhibitory concentrations of 3-oxo-C12-HSL, both sarA expression and agr expression were inhibited, indicating that the action of 3-oxo-C12-HSL is mediated at least in part through antagonism of quorum sensing in S. aureus. Spent culture supernatants from Pseudomonas aeruginosa, which produces both 3-oxo-C12-HSL and N-butanoyl-homoserine lactone (C4-HSL), also inhibited agr expression, although C4-HSL itself was inactive in this assay. Since quorum sensing in S. aureus depends on the activities of membrane-associated proteins, such as AgrB, AgrC, and AgrD, we investigated whether AHLs perturbed S. aureus membrane functionality by determining their influence on the membrane dipole potential. From the binding curves obtained, a dissociation constant of 7 muM was obtained for 3-oxo-C12-HSL, indicating the presence of a specific saturable receptor, whereas no binding was observed for C4-HSL. These data demonstrate that long-chain 3-oxo-substituted AHLs, such as 3-oxo-C12-HSL, are capable of interacting with the S. aureus cytoplasmic membrane in a saturable, specific manner and at sub-growth-inhibitory concentrations, down-regulating exotoxin production and both sarA and agr expression.
CORRESPONDENCE ON STEEL RAILS. (1934)

Keywords STEEL, RAILS, RAILWAYS, BESSEMER, WEARING, MANUFACTURE, TESTS, FAILURES, FRACTURE, FLANGES, MANGANESE, CARBON, COOLING, TRACK, FISSURES, YIELD, FALLING, WEIGHT, HARDENING, ACID, BESSEMER, PROCESS, TRANSVERSE... Show All