gebhart/patrepeval huggingface dataset:
Choreographing the extended agent: performance graphics for dance theater (2005)

The marriage of and interactive image has been a persistent dream over the past decades, but reality has fallen far short of potential for both technical and conceptual reasons. This thesis proposes a new approach to the problem and lays out the theoretical, technical and aesthetic framework for the innovative art form of digitally augmented human movement. I will use as example works a series of installations, digital projections and compositions each of which contains a choreographic component---either through collaboration with a choreographer directly or by the creation of artworks that automatically organize and understand purely virtual movement. These works lead up to two unprecedented collaborations with two of the greatest choreographers working today; new pieces that combine and interactive projected light using real-time motion capture live on stage. 
The existing field of dance technology is one with many problems. This is a domain with many practitioners, few techniques and almost no a field that is generating experimental productions with every passing week, has literally hundreds of citable pieces and no canonical works; a field that is oddly disconnected from modern dance's history, pulled between the realities of the body and those of computer art, and has no influence on the prevailing digital art paradigms that it consumes. 
This thesis will seek to address each of these problems: by providing techniques and a basis for practical theory; by building artworks with resources and people that have never previously been brought together, in theaters and in front of audiences previously inaccessible to the field; and by proving through demonstration that a profitable and important dialogue between digital art and the pioneers of modern can in fact occur. 
The methodological perspective of this thesis is that of biologically inspired, agent-based artificial intelligence, taken to a high degree of technical depth. The representations, algorithms and techniques behind such agent architectures are extended and pushed into new territory for both interactive art and artificial intelligence. In particular, this thesis will focus on the control structures and the rendering of the extended agents bodies, the tools for creating complex agent-based artworks in intense collaborative situations, and the creation of agent structures that can span live image and interactive sound production. Each of these parts becomes an element of what it means to choreograph an extended agent for live performance. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)
Search for Flavor-Changing Neutral-Current Charm Decays (2006)

We search for rare FCNC charm decays of the form $X_c^+\\to h^+\\llp$, where $X_c^+$ is a charm hadron, $h$ is a pion, kaon or proton, and $\\ell^{(}{'}^{)}$ is an electron or a muon. In the pion and kaon modes, we study both $D^+$ and $D_s^+$ decays, while in the proton modes we study $\\Lambda_c^+$ decays. Based on a data sample of 288${fb}^{-1}$ of $e^+e^-$ collisions collected by BABAR, we set preliminary 90% confidence level limits between 4 to 40$\\times10^{-6}$ for the branching fractions of the different decay modes. For most decay modes, our analysis provides a significant improvement over previous results.
Rigorous hybrid systems simulation with continuous-time discontinuities and discrete-time components (2007)

Previous research in the modeling and simulation of hybrid systems led to the development of a general hybrid systems modeling language (HSML). In more recent work, we have implemented this concept in software. The standard Matlab model framework and integration algorithms have been extended to support state-event handling in continuous-time components and to deal with embedded discrete-time components, with utmost accuracy and efficiency. In this paper we overview the algorithmic implementation of the HSML ideas and language constructs for dealing with state events and embedded discrete-time components in Matlab. A practical example (a separately-excited DC motor coupled via a gear-train to a load driven by a digital controller) is presented to demonstrate the efficacy of these extensions.
Combinational logic synthesis for LUT based field programmable gate arrays (1996)

The increasing popularity of the field programmable gate-array (FPGA) technology has generated a great deal of interest in the algorithmic study and tool development for FPGA-specific design automation problems. The most widely used FPGAs are LUT based FPGAs, in which the basic logic element is a K -input one-output lookup-table (LUT) that can implement any Boolean function of up to K variables. This unique feature of the LUT has brought new challenges to logic synthesis and optimization, resulting in many new techniques reported in recent years. This article summarizes the research results on combinational logic synthesis for LUT based FPGAs under a coherent framework. These results were dispersed in various conference proceedings and journals and under various formulations and terminologies. We first present general problem formulations, various optimization objectives and measurements, then focus on a set of commonly used basic concepts and techniques, and finally summarize existing synthesis algorithms and systems. We classify and summarize the basic techniques into two categories, namely, logic optimization and technology mapping , and describe the existing algorithms and systems in terms of how they use the classified basic techniques. A comprehensive list of references is compiled in the attached bibliography.
Conclusive Evidence for an SN2‐Si Mechanism in the B(C6F5)3‐Catalyzed Hydrosilylation of Carbonyl Compounds: Implications for the Related Hydrogenation (2008)

Just ask silicon: An experimentally straightforward yet effective Walden-type analysis showcases the usefulness of silanes with a stereogenic silicon center as stereochemical probes. The B(C6F5)3-catalyzed hydrosilylation and likely the related hydrogenation proceed through linear B-H-Si-O transition states, as verified by flawless inversion of the absolute configuration at silicon (see scheme).
The Hybrids Algorithm Based on Fuzzy Cognitive Map for Fuzzy Time Series Prediction (2014)

Fuzzy logic relationship groups are crucial to fuzzy time series prediction. In generally, fuzzy logic relationship groups can be constructed by manually mining fuzzy logic relationship between adjacent data in time series. However, for the large-scale or long-term time series, the way of manually constructing fuzzy logical relationship groups is difficult and infeasible. In this paper, a hybrids prediction algorithm based on Fuzzy Cognitive Map (FCM) is proposed, in which fuzzy c-means clustering algorithm is used to construct the framework of FCM and genetic algorithm (GA) is applied to learn weights of FCM. Finally, a fully learned fuzzy cognitive map is used to represent, store fuzzy logic relationships of fuzzy time series and realize prediction. A benchmark time series — the enrollments of University of Alberta time series is applied to validate the feasibility and effectiveness of the proposed algorithm, whose results show that the proposed prediction algorithm based on FCM is effective and can obtain the satisfactory prediction precision. It is a potential virtue that the proposed algorithm can automatically process the prediction problem of the large-scale or long-term time series.
Robustness of plant quantitative disease resistance is provided by a decentralized immune network (2020)

Quantitative disease resistance (QDR) represents the predominant form of resistance in natural populations and crops. Surprisingly, very limited information exists on the biomolecular network of the signaling machineries underlying this form of plant immunity. This lack of information may result from its complex and quantitative nature. Here, we used an integrative approach including genomics, network reconstruction, and mutational analysis to identify and validate molecular networks that control QDR in <i>Arabidopsis thaliana</i> in response to the bacterial pathogen <i>Xanthomonas campestris</i> To tackle this challenge, we first performed a transcriptomic analysis focused on the early stages of infection and using transgenic lines deregulated for the expression of <i>RKS1</i>, a gene underlying a QTL conferring quantitative and broad-spectrum resistance to <i>X</i><i>campestris</i><i>RKS1</i>-dependent gene expression was shown to involve multiple cellular activities (signaling, transport, and metabolism processes), mainly distinct from effector-triggered immunity (ETI) and pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) responses already characterized in <i>A</i><i>thaliana</i> Protein-protein interaction network reconstitution then revealed a highly interconnected and distributed RKS1-dependent network, organized in five gene modules. Finally, knockout mutants for 41 genes belonging to the different functional modules of the network revealed that 76% of the genes and all gene modules participate partially in RKS1-mediated resistance. However, these functional modules exhibit differential robustness to genetic mutations, indicating that, within the decentralized structure of the QDR network, some modules are more resilient than others. In conclusion, our work sheds light on the complexity of QDR and provides comprehensive understanding of a QDR immune network.
Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3 (2020)

Overexpression of D-type cyclins in human cancer frequently occurs as a result of protein stabilization, emphasizing the importance of identification of the machinery that regulates their ubiqutin-dependent degradation. Cyclin D3 is overexpressed in ~50% of Burkitt's lymphoma correlating with a mutation of Thr-283. However, the E3 ligase that regulates phosphorylated cyclin D3 and whether a stabilized, phosphorylation deficient mutant of cyclin D3, has oncogenic activity are undefined. We describe the identification of SCF-Fbxl8 as the E3 ligase for Thr-283 phosphorylated cyclin D3. SCF-Fbxl8 poly-ubiquitylates p-Thr-283 cyclin D3 targeting it to the proteasome. Functional investigation demonstrates that Fbxl8 antagonizes cell cycle progression, hematopoietic cell proliferation, and oncogene-induced transformation through degradation of cyclin D3, which is abolished by expression of cyclin D3T283A, a non-phosphorylatable mutant. Clinically, the expression of cyclin D3 is inversely correlated with the expression of Fbxl8 in lymphomas from human patients implicating Fbxl8 functions as a tumor suppressor.
Quality assuring specification and design (1990)

Specification and design have a decisive influence over the quality of software and software-based systems. Much of the value of products is vested in the specification and in early phases of design. Yet the concepts of specification and design are poorly understood, and the practice of quality assurance of specifications, as products in their own right, has not been established. The paper defines the notions of specification and design and proposes a model that can be used in the measurement-based quality assurance of both. The model is illustrated in an example relating to a very simple communication system.
Modeling of optical scatterometry with finite-number-of-periods gratings (1999)

Optical scatterometry (OS) is a promising new technique for the in-line metrology of submicron features since it is non- invasive, rapid and highly accurate for multiparametric CD- measurements of submicon features. A serious drawback of the method is the need for relative large periodic areas to measure at. This is caused by the underlying model of plane- wave incidence. In this paper, the reduction of the measuring field to a few square microns is proposed. In this case, the diffraction of a focussed beam from a grating with a finite number of periods has to be investigated. This is done by means of rigorous modeling. One of the most essential outcomes is that, while increasing the number of covered grating periods with a wider beam, the integrated diffraction efficiency approaches very quickly the value obtained with plane wave diffraction on an infinite grating. Besides, it can be shown that both - a lateral shift as well as a moderate defocusing have negligible impact even at very small beam diameters. In addition, an effective model was developed for the efficient simulation of 2(theta) - scatterometry on FNPs.
Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53 Independent of Increased Ribosome Content (2019)

The role of MYC in regulating p53 stability as a function of increased ribosome biogenesis is controversial. On the one hand, it was suggested that MYC drives the overexpression of ribosomal proteins (RP)L5 and RPL11, which bind and inhibit HDM2, stabilizing p53. On the other, it has been proposed that increased ribosome biogenesis leads the consumption of RPL5/RPL11 into nascent ribosomes, reducing p53 levels and enhancing tumorigenesis. Here, we show that the components that make up the recently described impaired ribosome biogenesis checkpoint (IRBC) complex, RPL5, RPL11, and <i>5S</i> rRNA, are reduced following <i>MYC</i> silencing. This leads to a rapid reduction in p53 protein half-life in an HDM2-dependent manner. In contrast, MYC induction leads to increased ribosome biogenesis and p53 protein stabilization. Unexpectedly, there is no change in free RPL5/RPL11 levels, but there is a striking increase in IRBC complex bound to HDM2. Our data support a cell-intrinsic tumor-suppressor response to MYC expression, which is presently being exploited to treat cancer. SIGNIFICANCE: Oncogenic MYC induces the impaired ribosome biogenesis checkpoint, which could be potentially targeted for cancer treatment.
An integral approach for discretizing the reservoir flow equations (1988)

An approach for discretizing the integral form of the flow equations in porous media is proposed. The method has the advantage of providing the correct block volume calculations and steady-state flow in curvilinear coordinates. The harmonic mean for permeability is also obtained from the discretization. The equations are developed for a general orthogonal curvilinear grid system in terms of the components of the metric tensor.
A rapid and sensitive culture test for the laboratory diagnosis of genital herpes in women. (1986)

A rapid and sensitive cell culture test has been developed to detect herpes simplex virus (HSV) in women with genital herpes. The virus is cultured by inoculation and centrifugation of cell monolayers, and the virus inclusions are detected using an indirect immunofluorescence test. The test takes only 48 hours to complete compared with the conventional cell culture test, which may take up to eight days. Of a total of 2100 cervical specimens collected from unselected women attending a sexually transmitted diseases (STD) clinic and inoculated in parallel, HSV was isolated from 55 specimens by either or both tests. Of these 55 positive specimens, 54(98%) were positive by the rapid test but only 24(44%) by the conventional test (McNemars test; p less than 0.001).
Three-Dimensional Cell Morphometry for the Quantification of Cell–Substrate Interactions (2012)

The initial attachment of cells to biomaterials is an important indicator of longer term cell-substrate biocompatibility. To study and quantify this interaction, we have developed a protocol for measuring temporal changes in the three-dimensional (3D) morphology of mammalian cells seeded onto different substrates using fluorescence confocal laser scanning microscopy and image processing techniques. This method has been used to investigate how morphology parameters, such as cell thickness, volume, and the footprint area, change over time for osteosarcoma cells on uncoated glass control, fibronectin-coated glass, and titanium substrates. Consistent with other studies, our results show that the presence of a fibronectin coating significantly increases the rate of cell spreading, judged by an increase in the cell footprint area and a decrease in cell thickness, indicating enhanced biocompatibility. Using similar criteria, the same cell line was observed to spread faster on titanium than on uncoated glass. We propose that 3D cell morphometry is a valuable multiparametric tool for quantifying initial cell-substrate interactions providing data which has important applications in quality control for ensuring product/batch consistency and for developing tailored surface finishes.
Data from A Single Supratherapeutic Dose of Vorinostat Does Not Prolong the QTc Interval in Patients with Advanced Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; This dedicated QTc phase I study, conducted in advanced-stage cancer patients, assessed the effect of a single supratherapeutic dose (800 mg) of vorinostat on the QTc interval.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; A randomized, partially blind, placebo-controlled, two-period, crossover study was conducted. Patients (&lt;i&gt;n&lt;/i&gt; = 25) received single doses of 800 mg vorinostat and placebo in the fasted state. Holter electrocardiogram monitoring was done before each treatment and for 24 h postdose. Blood samples for vorinostat concentration were collected through 24 h postdose following vorinostat treatment only. Prescribed electrocardiogram and blood sampling times were designed to capture the expected &lt;i&gt;C&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; of vorinostat.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Twenty-four of the 25 patients enrolled in the study were included in the QTc analysis. The upper bound of the two-sided 90 confidence interval for the QTcF interval for the placebo-adjusted mean change from baseline of vorinostat was &lt;10 ms at every time point. No patient had a QTcF change from baseline value &gt;30 ms. One patient had QTcF values &gt;450 ms (seen after both vorinostat and placebo administration) and none had values &gt;480 ms. Mean AUC&lt;sub&gt;0-&lt;/sub&gt; and &lt;i&gt;C&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt; values attained were on the order of 1.93- and 1.41-fold higher, respectively, compared with the 400 mg clinical dose. Based on assessment of clinical and laboratory adverse experiences, single doses of 800 mg vorinostat were generally well tolerated.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Administration of a single supratherapeutic dose of the histone deacetylase inhibitor vorinostat is not associated with prolongation of the QTc interval. A dedicated QTc study in advanced cancer patients is a robust means for assessing risk for ventricular repolarization prolongation. (Clin Cancer Res 2009;15(22):707784)&lt;/p&gt;&lt;/div&gt;
Analytical Applications of Enzymatic Growth of Quantum Dots (2010)

We have developed an analytical assay to detect the enzymatic activity of acetylcholine esterase and alkaline phosphatase based on the generation of quantum dots by enzymatic products. Acetylcholine esterase converts acetylthiocholine into thiocholine. The latter enhances the rate of decomposition of sodium thiosulfate into H(2)S, which in the presence of cadmium sulfate yields CdS quantum dots showing a time dependent exponential growth, typical of autocatalytic processes. This assay was also applied to detect acetylcholine esterase inhibitors. Alkaline phosphatase hydrolyzes thiophosphate and yields H(2)S, which instantly reacts with Cd(2+) to give CdS quantum dots. The formation of CdS quantum dots in both reactions was followed by fluorescence spectroscopy and showed dependence on the concentration of enzyme and substrate.
Activation of Organonitriles toward β-Electrophilic Attack. Synthesis and Characterization of Methyleneamide (Azavinylidene) Complexes of Rhenium (2002)

Treatment of the nitrile complexes cis-[ReCl(NCR)(dppe)(2)] (R = aryl; dppe = Ph(2)PCH(2)CH(2)PPh(2)) with [Et(2)OH][BF(4)] or SiMe(3)CF(3)SO(3) in CH(2)Cl(2) led to the formation of the methyleneamide (alkylideneamide or azavinylidene) compounds cis-[ReCl[NC(E)C(6)H(4)X-4](dppe)(2)]Y [E = H; X = OMe (1b), Me (1c), H (1d), F (1e), or Cl (1f), Y = BF(4); E = SiMe(3), X = Me (1c'), Y = CF(3)SO(3)] and trans-[ReCl[NC(H)C(6)H(4)X-4](dppe)(2)][BF(4)] [X = NEt(2) (2a), OMe (2b), H (2d), F (2e), or Cl (2f)]. They were characterized by multinuclear NMR spectrometry and X-ray crystallography (2e) which shows that the methyleneamide ligand exhibits linear (three-electron donor) geometry and behaves as a strong pi-electron acceptor. The complex (31)P[(1)H] and (1)H [NC(H)C(6)H(4)X-4] NMR patterns for the cis isomers were analyzed as ABCD and ABCDX (X part) spin systems, respectively. Complexes 1 and 2 undergo deprotonation by base to form the trans isomers of the corresponding nitrile complexes, trans-[ReCl(NCC(6)H(4)X-4)(dppe)(2)] [X = NEt(2) (3a), OMe (3b), H (3d), F (3e), or Cl (3f)] whose spectroscopic data are also presented and which on protonation give the corresponding trans isomers of the methyleneamide complexes (2). Reactions of cis-[ReCl(NCR)(dppe)(2)] with [Et(3)O][PF(6)] resulted in their oxidation and isomerization to afford trans-[ReCl(NCC(6)H(4)X-4)(dppe)(2)][PF(6)] [X = Me (4c), H (4d), or Cl (4f)].
Ionization of β-carbolines in concentrated hydroxide solutions (1986)

The ionization of several β-carbolines (norharman or β-carboline, harman, harmine, harmaline, and tetrahydroharmine) in concentrated potassium hydroxide solutions have been examined. The pKa values, calculated using the H– acidity function, indicate that these compounds are stronger acids than indole and their acidities increase with the degree of aromaticity of the compounds in the order tetrahydro < dihydro < fully aromatic β-carbolines. This sequence can be interpreted in terms of resonance stabilization of the indolate anion.
Approximation and compression of arbitrary time-series based on nonlinear dynamics (2002)

Given a measured output signal from a nonlinear deterministic process in the form of a time series we estimate initial conditions in successive time intervals which reproduce in an optimal way sections of the output signal. Thus, the measured signal can be coded in terms of model equations, its parameters and a set of initial conditions. We achieve signal approximation and compression at the same time. We discuss continuous-time and discrete-time approaches.
Influence of Controlling Plasma Gas Species and Temperature on Reactive Species and Bactericidal Effect of the Plasma (2021)

In this study, plasma gas species and temperature were varied to evaluate the reactive species produced and the bactericidal effect of plasma. Nitrogen, carbon dioxide, oxygen, and argon were used as the gas species, and the gas temperature of each plasma was varied from 30 to 90 °C. Singlet oxygen, OH radicals, hydrogen peroxide, and ozone generated by the plasma were trapped in a liquid, and then measured. Nitrogen plasma produced up to 172 µM of the OH radical, which was higher than that of the other plasmas. In carbon dioxide plasma, the concentration of singlet oxygen increased from 77 to 812 µM, as the plasma gas temperature increased from 30 to 90 °C. The bactericidal effect of carbon dioxide and nitrogen plasma was evaluated using bactericidal ability, which indicated the log reduction per minute. In carbon dioxide plasma, the bactericidal ability increased from 5.6 to 38.8, as the temperature of the plasma gas increased from 30 to 90 °C. Conversely, nitrogen plasma did not exhibit a high bactericidal effect. These results demonstrate that the plasma gas type and temperature have a significant influence on the reactive species produced and the bactericidal effect of plasma.