gebhart/patrepeval huggingface dataset:
An overview of text-independent speaker recognition: From features to supervectors (2009)

Abstract\n This paper gives an overview of automatic speaker recognition technology, with an emphasis on text-independent recognition. Speaker recognition has been studied actively for several decades. We give an overview of both the classical and the state-of-the-art methods. We start with the fundamentals of automatic speaker recognition, concerning feature extraction and speaker modeling. We elaborate advanced computational techniques to address robustness and session variability. The recent progress from vectors towards supervectors opens up a new area of exploration and represents a technology trend. We also provide an overview of this recent development and discuss the evaluation methodology of speaker recognition systems. We conclude the paper with discussion on future directions.
Two-side sealer operation (2013)

Design parameters of a balanced sealing device are substantiated. Different design synchronizers are tested with an eye to ensure joint operation of air sealing devices. The article describes laboratory studies of operation modes of the sealing device and different design synchronizers.
Selection of natural health products for clinical trials: a preclinical template (2009)

In preparation for a clinical trial on the efficacy of Echinacea products with a pediatric population, a rational method for selection of test products was developed, based on phytochemical and bioassay evaluation. Ten currently available commercial products of Echinacea angustifolia (EA) or Echinacea purpurea (EP) were selected, and 3 bottles of each of 2 different lots were purchased for each product. Investigators were blinded to product identity before phytochemical analysis. Lot-to-lot variation was small, but product variation due to species and formulation was large. Products derived from ethanol extracts had low polysaccharide content and high levels of alkamides (EA), echinacoside (EA), cynarin (EA), cichoric acid (EP), and caftaric acid (EP). These products possessed high antiviral activities that differed between EA and EP products, but limited immune activation properties. In contrast, products derived without ethanol extraction had higher polysaccharide levels, but low levels of other components. These aqueous compounds showed immunostimulant activity as measured in a mouse macrophage model and a somewhat different antiviral profile. The choice of Echinacea product for clinical trial must therefore consider the impact of immune enhancement, the specific viral infection targeted, and the potential to reduce symptoms via antiinflammatory activity. Product selection may also depend on whether the intent of the trial is prophylaxis or treatment.
Kobophenol A Isolated from Roots of Caragana sinica (Buc’hoz) Rehder Exhibits Anti-inflammatory Activity by Regulating NF-κB Nuclear Translocation in J774A.1 Cells (2018)

Kobophenol A (KPA) is a biologically active natural compound isolated from the roots of Caragana sinica (Buc'hoz) Rehder (C. sinica). However, the anti-inflammatory effects of KPA have not been reported. This study aims to find out whether KPA isolated from roots of C. sinica can act as a potential substance on inflammation and analyze the molecular mechanism using the lipopolysaccharide (LPS)-stimulated J774 A.1 macrophage cell line. We showed that KPA treatment significantly suppressed the production of nitric oxide (NO) by inhibiting inducible nitric oxide synthase (iNOS) expression in a dose-dependent manner without cytotoxicity. In the KPA also inhibited pro-inflammatory cytokine gene expression and production, such as interleukin-1β (IL-1β) and interleukin-6 (IL-6) in LPS-stimulated J774 A.1 cells. As continuing study on the mechanisms involved, we confirmed that these effects of KPA were related to the inhibition of nuclear factor-κB (NF-κB) pathway including the suppression of IκB kinase α/β (IKKα/β) phosphorylation and translocation of NF-κB into the nucleus. Taken together, the present study is the first to demonstrate that KPA isolated from C. sinica suppresses the expression of inflammatory mediators and cytokines by inhibiting NF-κB nuclear translocation in LPS-stimulated J774 A.1 macrophages. KPA may be a potential candidate for the treatment of inflammatory diseases in the future.
Virtual Humans in the Mission Rehearsal Exercise System (2003)

This paper summarizes some of the progress that has been made toward populating such a world with embodied conversational agents
The Aiding of MEMS INS/GPS Integration Using Artificial Intelligence for Land Vehicle Navigation (2006)

This paper applies two Artificial Intelligence (AI) techniques, fuzzy logic and expert system, to enhance the Kalman filter-based MEMS INS/GPS integration. For better INS error control, the expert knowledge on vehicle dynamics is utilized to simplify dynamics models and to extend measurement update schemes in the velocity filter. To optimize position fusion, a fuzzy inference system is developed to provide GPS signal degradation information for modification of the innovation-based adaptive measurement covariance in the position filter. The effectiveness of the proposed AI-based enhancement methods is demonstrated through several field tests.
[Results of Krasovitov's dermatoplasty]. (1989)

The authors analyse their results of reimplantation of skin after Krasovitov in 34 patients. In 23 cases there were good or satisfactory results and in 10 cases where there were deviations from this technique the results were not satisfactory. The most frequent mistake was leaving of the scalped skin on the "feeding" pedicle. In scalped wounds associated with bone fractures the authors used perosseous osteosynthesis which stabilized the fracture and did not cause difficulties in taking care of the reimplanted skin. To improve the results of the operations drugs influencing the rheologic properties of the blood and the vegetative innervation were administered.
The GLOBE 3D Genome Platform Live Movie of the Presentation (2009)

The combination of genome sequence and structure, its annotation and experimental data in an accessible and &#13;\n&#13;\ncomprehensible way is a major challenge. Increasingly, there are a large number of extremely divergent data &#13;\n&#13;\nsets: the sequence itself, genes, regulatory regions, various forms of reoccurring sequence features and clone sets &#13;\n&#13;\netc. Currently, one possibility to represent this information in a visual form - and thus to reveal its scientific &#13;\n&#13;\nmeaning - is to use genome browsers such as "Ensembl" or "The UCSC Genome Browser". These browsers have &#13;\n&#13;\nbeen beneficial in the understanding of the complex organization of genomes. However, there are also huge &#13;\n&#13;\nlimitations concerning their focus on linear presentation, standardized input and data bank accessibility. Also &#13;\n&#13;\ncustomisability by a remote user with special requirements is difficult.&#13;\n&#13;\nTherefore, the GLOBE-Consortium has developed the next generation genome viewer - the GLOBE 3D-Viewer &#13;\n&#13;\n- to visualize multi-dimensional data sets from various sources in an easy intuitive manor while accounting for &#13;\n&#13;\nthe complexity of genome organization. Together with an easily accessible data-warehouse for archiving (un-&#13;\n&#13;\n)published experimental data and the Erasmus Computing Grid (ECG) for fast interactive large-scale &#13;\n&#13;\n(correlative) analysis the GLOBE-Consortium creates an intuitive holistic environment for genome research. &#13;\n&#13;\nThus, the GLOBE 3D-Viewer sets the new standard to integrate complex genomic data sets within a single &#13;\n&#13;\nholistic display system and thus is major advance for scientific and clinical genome research.
Perceptually based brush strokes for nonphotorealistic visualization (2004)

An important problem in the area of computer graphics is the visualization of large, complex information spaces. Datasets of this type have grown rapidly in recent years, both in number and in size. Images of the data stored in these collections must support rapid and accurate exploration and analysis. This article presents a method for constructing visualizations that are both effective and aesthetic. Our approach uses techniques from master paintings and human perception to visualize a multidimensional dataset. Individual data elements are drawn with one or more brush strokes that vary their appearance to represent the element's attribute values. The result is a nonphotorealistic visualization of information stored in the dataset. Our research extends existing glyph-based and nonphotorealistic techniques by applying perceptual guidelines to build an effective representation of the underlying data. The nonphotorealistic properties the strokes employ are selected from studies of the history and theory of Impressionist art. We show that these properties are similar to visual features that are detected by the low-level human visual system. This correspondence allows us to manage the strokes to produce perceptually salient visualizations. Psychophysical experiments confirm a strong relationship between the expressive power of our nonphotorealistic properties and previous findings on the use of perceptual color and texture patterns for data display. Results from these studies are used to produce effective nonphotorealistic visualizations. We conclude by applying our techniques to a large, multidimensional weather dataset to demonstrate their viability in a practical, real-world setting.
Effect of annealing current density on the microstructure of nanocrystalline FeCuNbSiB alloy (2007)

The amorphous Fe73.9Nb3.1Cu0.9Si13.2B8.9 alloy has been submitted to current annealing at four different current densities ranging from 3.3×107to3.9×107A∕m2. The effect of annealing current density on the structure of the resulting nanocrystalline phase in the same alloy has been studied using in situ wide angle x-ray scattering and small angle x-ray scattering measurements. Some information about the magnetic properties has been obtained from Mössbauer measurements. It is found that higher current density results in significant grain refinement and decrease in the lattice parameter of the nanocrystalline phase, as well as lowering of x-ray contrast between nanocrystalline grains and the amorphous grain boundary phase. These results suggest a variation, with increasing current density, in the composition of the nanocrystalline grains and/or the amorphous grain boundary phase and are corroborated by ex situ Mössbauer spectroscopy measurements on current annealed samples.
Uncertainties in passive seismic monitoring (2009)

The use of passive seismic techniques to monitor oil- field completion and production processes is on the rise. Stress changes induced by such reservoir activities as hydraulic fracturing, water injection, or fluid extraction will often result in failure of the rocks with a concurrent release of seismic energy in the form of compressional (P) and shear (S) waves. Passive seismic monitoring is based on recording these emitted waves and then using their arrival times to estimate the location of the failure events.
Sleep Stage Assessment Using Power Spectral Indices of Heart Rate Variability With a Simple Algorithm (2012)

Clinical researchers do not typically assess sleep with polysomnography (PSG) but rather with observation. However, methods relying on observation have limited reliability and are not suitable for assessing sleep depth and cycles. The purpose of this methodological study was to compare a sleep analysis method based on power spectral indices of heart rate variability (HRV) data to PSG. PSG and electrocardiography data were collected synchronously from 10 healthy women (ages 20-61 years) over 23 nights in a laboratory setting. HRV was analyzed for each 60-s epoch and calculated at 3 frequency band powers (very low frequency [VLF]-hi: 0.016-0.04 Hz; low frequency [LF]: 0.04-0.15 Hz; and high frequency [HF]: 0.15-0.4 Hz). Using HF/(VLF-hi + LF + HF) value, VLF-hi, and heart rate (HR) as indices, an algorithm to categorize sleep into 3 states (shallow sleep corresponding to Stages 1 & 2, deep sleep corresponding to Stages 3 & 4, and rapid eye movement [REM] sleep) was created. Movement epochs and time of sleep onset and wake-up were determined using VLF-hi and HR. The minute-by-minute agreement rate with the sleep stages as identified by PSG and HRV data ranged from 32 to 72% with an average of 56%. Longer wake after sleep onset (WASO) resulted in lower agreement rates. The mean differences between the 2 methods were 2 min for the time of sleep onset and 6 min for the time of wake-up. These results indicate that distinguishing WASO from shallow sleep segments is difficult using this HRV method. The algorithm's usefulness is thus limited in its current form, and it requires additional modification.
Tetracaine Reports a Conformational Change in the Pore of Cyclic Nucleotide–gated Channels (1997)

Local anesthetics are a diverse group of clinically useful compounds that act as pore blockers of both voltage- and cyclic nucleotide-gated (CNG) ion channels. We used the local anesthetic tetracaine to probe the nature of the conformational change that occurs in the pore of CNG channels during the opening allosteric transition. When applied to the intracellular side of wild-type rod CNG channels expressed in Xenopus oocytes from the alpha subunit, the local anesthetic tetracaine exhibits state-dependent block, binding with much higher affinity to closed states than to open states. Here we show that neutralization of a glutamic acid in the conserved P region (E363G) eliminated this state dependence of tetracaine block. Tetracaine blocked E363G channels with the same effectiveness at high concentrations of cGMP, when the channel spent more time open, and at low concentrations of cGMP, when the channel spent more time closed. In addition, Ni2+, which promotes the opening allosteric transition, decreased the effectiveness of tetracaine block of wild-type but not E363G channels. Similar results were obtained in a chimeric CNG channel that exhibits a more favorable opening allosteric transition. These results suggest that E363 is accessible to internal tetracaine in the closed but not the open configuration of the pore and that the conformational change that accompanies channel opening includes a change in the conformation or accessibility of E363.
SET‐LRP of acrylates in air (2010)

Abstract Single Electron Transfer‐Living Radical Polymerization (SET‐LRP) represents a robust and versatile method for the rapid synthesis of macromolecules with well defined topology. In SET‐LRP, certain combinations of solvents and ligands facilitate the disproportionation of in situ generated Cu(I) species into “nascent” Cu(0) and Cu(II) species. A combination of heterogeneous and “nascent” Cu(0) activation yields polymers with very high chain end functionality. Under suitable conditions the tolerance toward oxygen must be increased since Cu(0), the activator in SET‐LRP, acts as an oxygen scavenger in all inert gas purification systems. Here we demonstrate that SET‐LRP of methyl acrylate can be conducted in the presence of air. The addition of a small amount of reducing agent hydrazine hydrate to the reaction mixture reduces Cu 2 O generated by the oxidation of Cu(0) with air, regenerating Cu(0) and allowing for the synthesis of polymers with predictable molecular weight and perfect retention of chain end functionality. The kinetics plots obtained under these conditions were identical to these generated by degassed samples. High conversions were achieved within a very short reaction time. In these SET‐LRP experiments, the reagents were not deoxygenated or subjected to standard degassing procedures such as freeze‐pump‐thaw or nitrogen sparging. This simple SET‐LRP procedure provides an efficient and economical approach to the synthesis of functional macromolecules. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 1190–1196, 2010
Coordination Chemistry of N-Heterocyclic Stannylenes: A Combined Synthetic and Mössbauer Spectroscopy Study (2011)

The N-heterocyclic stannylenes (NHSns), [(Dipp) N(CH(2))(n)N(Dipp)S n] (Dipp = 2,6- (i)Pr(2)C(6)H(3); n = 2, 1; n = 3, 5) and [((t)Bu) N(CHMe)(2)N((t)Bu)S n] (10) are competent ligands toward a variety of transition metal centers, as seen in the complexes [W(CO)(5)·1] (2), [(OC)(4)Fe(μ-1)(2)Fe(CO)(4)] (3), [(OC)(4)Fe(μ-1)Fe(CO)(4)] (4), [Fe(CO)(4)·5](n) (6, n = 1 or 2), [(OC)(4)Fe(μ-5)Fe(CO)(4)] (7), [Ph(3)PPt(μ-1)(2)PtPPh(3)] (8), [Fe(CO)(4)·10] (11), and [(η(5)-C(5)H(5))(OC)(2)Mn·10] (12). X-ray crystallographic studies show that the NHSns are structurally largely unperturbed binding to the metal, but in contrast to the parent NHCs, NHSns often adopt a bridging position across dinuclear metal units. The balance between terminal and bridging positions for the stannylene is evidently closely balanced as shown by the observation of both monomers and dimers for 6 in the solid state and in solution. (119)Sn and (57)Fe Mössbauer spectroscopy of the complexes shows the tin atoms in such complexes to be consistent with electron deficient Sn(II) centers.
PCR amplification from single seeds, facilitating DNA marker-assisted breeding (1993)

Journal Article PCR amplification from single seeds, facilitating DNA marker-assisted breeding Get access Guo-Liang Wang, Guo-Liang Wang Department of Soil and Crop Sciences, Texas A&M UniversityCollege Station, TX 77843, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Rod A. Wing, Rod A. Wing Department of Soil and Crop Sciences, Texas A&M UniversityCollege Station, TX 77843, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrew H. Paterson Andrew H. Paterson * Department of Soil and Crop Sciences, Texas A&M UniversityCollege Station, TX 77843, USA * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 21, Issue 10, 25 May 1993, Page 2527, https://doi.org/10.1093/nar/21.10.2527 Published: 25 May 1993 Article history Received: 17 March 1993 Revision received: 19 April 1993 Accepted: 19 April 1993 Published: 25 May 1993
Supplementary Figure 11 from Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers (2023)

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Progress in new ultraviolet reflective coating techniques (2011)

Current FUV instrumentation is seriously compromised by poor reflectivity. The best existing coatings for the 90 - 115 nm range are SiC (30% reflectivity across the band) and LiF/Aluminum (60% reflectivity from 100 nm to 115 nm). An improved coating therefore would enable the production of vastly more sensitive instruments in the 90 - 200 nm range. An additional goal in the development of an alternate FUV coating is to overcome the well-documented hygroscopic behaviors of LiF coatings, which currently impose handling concerns that in turn drive cost and schedule. The coatings we will develop in this effort must also function well through the conventional silicon-based detector bandpass (200 nm to 1100 nm). By ensuring that these new coatings are usable at many wavelengths, we will make it possible to incorporate ultraviolet instruments into future large missions without compromising the science capability of other instruments or increasing cost and risk due to handling issues.
Molecular Cloning and Expression of cDNA Encoding 3α,7α,12α-Trihydroxy-5β-cholestanoyl-CoA Oxidase from Rabbit Liver (1997)

The steroid side chain cleavage in bile acid formation is catalyzed by liver peroxisomal enzymes (Pedersen, J. I. and Gustafsson, J. (1980) FEBS Lett. 121, 345-348; Kase, F., Björkhem, I., and Pedersen, J. I. (1983) J. Lipid Res. 24, 1560-1567). We here describe the cloning and sequencing of a cDNA coding the first of these enzymes, a 3alpha,7alpha,12alpha-trihydroxy-5beta-choles tanoyl-CoA oxidase (THCA-CoA oxidase) from rabbit liver peroxisomes. After tryptic digestion of purified protein in a polyacrylamide gel, five peptides were isolated and sequenced. Using two oligonucleotides deduced from the amino acid sequence data, two overlappping clones were isolated from a rabbit liver cDNA library, which together made up a unique cDNA sequence of 2139 base pairs. It contained an open reading frame of 2046 base pairs encoding a protein of 681 amino acids with a molecular mass of 76,209 daltons. All five peptides could be localized within the sequence. Transfection of COS cells with the coding part of the cDNA resulted in a significant expression of THCA-CoA oxidase activity. We were not able to demonstrate 3alpha, 7alpha-dihydroxy-5beta-cholestanoyl-CoA oxidase activity under the same conditions. The obtained sequence showed 73.6% similarity with a proposed rat THCA-CoA oxidase and 81% similarity with a recently reported human branched chain acyl-CoA oxidase, indicating that these three proteins represent the same enzyme. The similarity with rat palmitoyl-CoA oxidase was 41.8%. The C-terminal tripeptide of the protein was SNL, a previously undescribed variant of the main class of peroxisomal targeting signals. Northern blot analysis revealed that the gene is transcribed in liver and kidney, and the major mRNA fraction had a size of approximately 2.6 kilobase pairs.
Relationship between inoculum density of the nematophagous fungus Paeeilomyces Zilacinus and control of Meloidogyne arenaria on tomato (l) (1991)

SUMMARY Five doses (0.01 - 0.1 - 1 - 10 and 100 g/m*) of a commercial product of Paecilowzyces lilacinus isolated from eggs of Meloidogyne incognita were applied in a powder formulation (10” sporedg of product) in a glasshouse pot experiment against large infestations of Meloidogyne arenan‘a. The trial was conducted over eleven months on three successive tomato crops, cv. Saint Pierre. Results showed that the number of fungal propagules in the soil was correlated to the initial dose applied and decreased progressively through the time with increased dose. Populations of M. arenaria were significantly reduced by the fungus at 10 and 100 g of spores/m2 in the second and third nematode generations. The number of colonized egg masses and the number of non-viable eggs increased with fungal inoculum and the fungus was most effective at a density of IO6 sporedg of soil. In.the highest level of control (100 Yo colonized egg masses) only 50 O/O of the eggs were parasitized. Twenty three percent of the larvae remained which constitutes an important residual inoculum potential. This fact and a rapid decrease in fungal density in soil below the acceptable control levels, limit the use of this fungus as a bioIogical control agent.
Motion adaptation on a wheelchair driving simulator (2014)

The objective of the AccesSim project is to design a wheelchair simulator using Virtual Reality and a robotic platform to detect and illustrate accessibility issues in complex environments. In order to be efficient, the robotic platform must provide haptic and vestibular feedbacks to different profile of end users: urbanists to wheelchair users. It must be modular and adaptable to each one of them. In this paper we focus our robotic platform capable of adapting its configuration and feedback rendering based on the user. The design of the platform is described. The capacity of the platform to reproduce the motion of a wheelchair in a specific study case is tested experimen-tally. Finally the results introduce the possibility of adapting the dynamic feedback rendering based on a specific user and environmental situations.
Analogue boundary scan architecture for DC and ACtesting (1996)

A new mixed-mode boundary scan architecture is developed. The digital part of this architecture complies with the IEEE Std 1149.1. For the analogue part, we propose a new boundary scan cell design and define 4 analogue test instructions. The control signals for each instruction are also described.