gebhart/patrepeval huggingface dataset:
The use of hydromulches in organic farming: Effect on different soil parameters in Central Spain (2020)

&amp;lt;p&amp;gt;In recent years, the problem arising from the weed control in perennial crops is increasing, both in young woody crops during the first years of cultivation and in established plantations. The control of weeds through herbicides, the most widespread practice, presents many inconveniences, among which we can mention the appearance of weeds resistant or tolerant to them, crop phytotoxicities, especially in young plantations, or the significant reduction in the active materials allowed. Another aspect to take into account is the search for techniques that allow saving crop water consumption by reducing soil evaporation&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;Therefore, in this work we evaluate the effect of three mixtures based on by-products derived from the agricultural sector, mixed with a binder and recycled paper paste and applied in liquid form on the ground with subsequent solidification (hydromulch), on different soil parameters (soil water content, temperatura and flow of CO&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt;) in a young olive plantation in containers of 700 liters capacity. Additionally, two control treatments were included (manual weeding and a no-weeding treatments).&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;In summary, and as preliminary results, hydromulches increased the soil water content, reduced slightly the soil temperature in the summer season and increased the flow of CO&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt;, indicative of a higher soil microbial activity, closely related with the air temperature and the soil moisture. These preliminary results position hydromulches as an interesting alternative to herbicides and the conventional plastic mulches.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;amp;#160;&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Keywords&amp;lt;/strong&amp;gt;: hydromulches, soil CO&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt; flow, soil temperatura, soil water content.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Acknowledgements&amp;lt;/strong&amp;gt;: Project RTA2015-00047-C05-03 - INIA (Spanish Ministry of Economy and Competitiveness).&amp;lt;/p&amp;gt;
Organocatalytic syn-Aldol Reactions of Dioxanones with (S)-Isoserinal Hydrate: Synthesis of l-Deoxymannojirimycin and l-Deoxyidonojirimycin (2009)

We report a new protocol for synthesis of L-1-deoxymannojirimycin, L-1-deoxyidonojirimycin, and the N-isopropyl derivative of the latter compound from the readily available precursors (S)-isoserinal hydrate and 2-tert-butyl-2-methyl-1,3-dioxan-5-one. The key steps include diastereoselective proline-catalyzed syn aldol transformation and a reductive amination/cyclization.
Physical characteristics and aerosolization performance of insulin dry powders for inhalation prepared by a spray drying method (2007)

The objective of this study was to investigate the influence of formulation excipients on the physical characteristics and aerosolization performance of insulin dry powders for inhalation. Insulin dry powders were prepared by a spray drying technique using excipients such as sugars (trehalose, lactose and dextran), mannitol and amino acids (L-leucine, glycine and threonine). High performance liquid chromatography and the mouse blood glucose method were used for determination of the insulin content. The powder properties were determined and compared by scanning electron microscopy, thermo-gravimetric analysis and size distribution analysis by a time-of-flight technique. The in-vitro aerosolization behaviour of the powders was assessed with an Aerolizer inhaler using a twin-stage impinger. Powder yield and moisture absorption were also determined. Results showed that there was no noticeable change in insulin content in any of the formulations by both assay methods. All powders were highly wrinkled, with median aerodynamic diameters of 2-4 microm, and consequently suitable for pulmonary administration. The tapped density was reduced dramatically when glycine was added. The powders containing mannitol, with or without L-leucine, were less sensitive to moisture. The highest respirable fraction of 67.3 +/- 1.3% was obtained with the formulation containing L-leucine, in contrast to formulations containing glycine and threonine, which had a respirable fraction of 11.2 +/- 3.9% and 23.5 +/- 2.5%, respectively. In addition, powders with good physical properties were achieved by the combination of insulin and trehalose. This study suggests that L-leucine could be used to enhance the aerosolization behaviour of the insulin dry powders for inhalation, and trehalose could potentially be used as an excipient in the formulations.
Modified impact of emotion on temporal discrimination in a transgenic rat model of Huntington disease (2013)

Huntington's disease (HD) is characterized by triad of motor, cognitive, and emotional symptoms along with neuropathology in fronto-striatal circuit and limbic system including amygdala. Emotional alterations, which have a negative impact on patient well-being, represent some of the earliest symptoms of HD and might be related to the onset of the neurodegenerative process. In the transgenic rat model (tgHD rats), evidence suggest emotional alterations at the symptomatic stage along with neuropathology of the central nucleus of amygdala (CE). Studies in humans and animals demonstrate that emotion can modulate time perception. The impact of emotion on time perception has never been tested in HD, nor is it known if that impact could be part of the presymptomatic emotional phenotype of the pathology. The aim of this paper was to characterize the effect of emotion on temporal discrimination in presymptomatic tgHD animals. In the first experiment, we characterized the acute effect of an emotion (fear) conditioned stimulus on temporal discrimination using a bisection procedure, and tested its dependency upon an intact central amygdala. The second experiment was aimed at comparing presymptomatic homozygous transgenic animals at 7-months of age and their wild-type littermates (WT) in their performance on the modulation of temporal discrimination by emotion. Our principal findings show that (1) a fear cue produces a short-lived decrease of temporal precision after its termination, and (2) animals with medial CE lesion and presymptomatic tgHD animals demonstrate an alteration of this emotion-evoked temporal distortion. The results contribute to our knowledge about the presymptomatic phenotype of this HD rat model, showing susceptibility to emotion that may be related to dysfunction of the central nucleus of amygdala.
Switchable Diastereoselectivity in Enantioselective [4+2] Cycloadditions with Simple Olefins by Asymmetric Binary Acid Catalysis (2013)

The exchange of the metal ion from InIII to ScIII in a binary acid catalyst leads to a switch in the diastereoselectivity of [4+2] cycloadditions. Simple olefins and β,γ-unsaturated α-ketoester were thus transformed to the corresponding exo or endo products, respectively, with excellent diastereoselectivity (up to 99:1 d.r.) and enantioselectivity (up to 99 % ee). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Unbalanced cryptic 5p deletion/17p duplication identified by subtelomeric FISH in a family with a boy with chimerism and a balanced t(4;5) (2003)

The use of subtelomeric FISH probes has greatly supplemented conventional chromosome analysis in detecting cryptic anomalies in patients with mental retardation (MR), dysmorphic features, and congenital malformations. We report a 3-month-old boy who was diagnosed with ambiguous genitalia, dysmorphic features, and developmental delay. Standard chromosome studies on blood revealed a chimeric karyotype of 46,XY,t(4;5)(q31.1;q14)[46]/46,XX[4]. The boy had intra-abdominal gonads that were testicular in origin by biopsy. Multiple dysmorphic features, marked hypotonia, developmental delay, poor growth, and relative macrocephaly were noted on physical exam. His 2.5-year-old sister also presented with hypotonia, developmental delay, relative macrocephaly, and similar dysmorphic stigmata. In addition, she was diagnosed with several internal malformations. Her karyotype was 46,XX. Due to the striking phenotypic similarity, subtelomeric FISH studies were initiated in the siblings. In addition to the known balanced karyotypic abnormalities, the boy was found to have a derivative chromosome 5 with a 5pter deletion and a 17pter duplication. This cryptic abnormality was also detected in his sister. Chromosome analysis of the father revealed a subtle balanced t(5;17)(p15.31;p13.1) which was confirmed by subtelomeric FISH, whereas the mother's chromosome complement was normal. This familial constellation illustrates the usefulness of subtelomeric FISH in the diagnosis of cryptic chromosome abnormalities in patients for whom conventional karyotype does not disclose findings sufficient to explain the observed phenotypic anomalies.
Design of reverse transcriptase–specific nucleosides to visualize early steps of HIV-1 replication by click labeling (2019)

Only a small portion of human immunodeficiency virus type 1 (HIV-1) particles entering the host cell results in productive infection, emphasizing the importance of identifying the functional virus population. Because integration of viral DNA (vDNA) is required for productive infection, efficient vDNA detection is crucial. Here, we use click chemistry to label viruses with integrase coupled to eGFP (HIV<sub>IN-eGFP</sub>) and visualize vDNA. Because click labeling with 5-ethynyl-2'-deoxyuridine is hampered by intense background staining of the host nucleus, we opted for developing HIV-1 reverse transcriptase (RT)-specific 2'-deoxynucleoside analogs that contain a clickable triple bond. We synthesized seven propargylated 2'-deoxynucleosides and tested them for lack of cytotoxicity and viral replication inhibition, RT-specific primer extension and incorporation kinetics <i>in vitro</i>, and the capacity to stain HIV-1 DNA. The triphosphate of analog A5 was specifically incorporated by HIV-1 RT, but no vDNA staining was detected during infection. Analog A3 was incorporated <i>in vitro</i> by HIV-1 RT and human DNA polymerase γ and did enable specific HIV-1 DNA labeling. Additionally, A3 supported mitochondria-specific DNA labeling, in line with the <i>in vitro</i> findings. After obtaining proof-of-principle of RT-specific DNA labeling reported here, further chemical refinement is necessary to develop even more efficient HIV-1 DNA labels without background staining of the nucleus or mitochondria.
Molecular mechanisms of niclosamide antitumor activity (2015)

In this review the recent data regarding the antitumor activity of niclosamide and the molecular mechanisms of its antitumor activity are presented. Niclosamide has been used in the clinic for the treatment of intestinal parasite infections. In recent years in several screening investigations of various drugs and chemical compounds niclosamide was identified as a potential anticancer agent. Niclosamide not only inhibits the Wnt/β-catenin, mTORC1, STAT3, NF-κB and Notch signaling pathways, but also targets mitochondria in cancer cells to induce growth inhibition and apoptosis. A number of studies have established the anticancer activity of niclosamide in both in vitro and in vivo in xenotransplantation models using human tumors and immunodeficient mice. It is important that niclosamide is active not only against tumor cells but also cancer stem cells. Normal cells are resistant to niclosamide. The accumulated experimental data suggest niclosamide is a promising drug for the treatment of various types of cancer.
Novel Triene-.BETA.-lactone Antibiotics, Oxazolomycin Derivative and Its Isomer, Produced by Streptomyces sp. KSM-2690. (2000)

In the course of our screening for novel antibacterial antibiotics produced by microorganisms, a strain termed KSM-2690was found to produce a new complex of triene-/3-lactone antibiotics in the culture filtrate. The active principle was recovered from the broth filtrate with ethyl acetate extraction and could be divided into six components, three major components KSM-2690 A (1), B (2) and C (3), and three minor components KSM-2690 D, E and F, on the basis of their respective order of elution under the reverse-phase HPLC. The characteristic UV and IR spectra of their components were similar to those of oxazolomycins1'2^indicating that these new compoundsare members of the triene-/3-lactone group of antibiotics.
Author response: Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria (2021)

Comparative transcriptomics of whole blood can be used to evaluate the systemic host response and its concordance between human and mouse malaria and aid the selection of appropriate models for translational malaria research.
A complex high-temperature phase in Cu9Zr2 (1984)

CuZr alloys in the vicinity of Cu9Zr2 show a remarkable three-dimensional long-period superstructure based on a face centered cubic lattice. The CuZr alloy is studied by electron diffraction and high resolution electron microscopy. The complete structure remains unresolved but it is suggested that the structure consists of space filling polyhedral domains limited by octahedral as well as cube planes. The periodicity along the cube directions is mostly well defined but the spacing between the octahedral (111) planes is variable and the correlation between neighbouring polyhedra is small. CuZr-Legierungen in der Nähe von Cu9Zr2, zeigen eine deutliche dreidimensionale langperiodische Superstruktur auf der Grundlage eines flächenzentrierten kubischen Gitters. Die CuZr-Legierung wird mittels Elektronenbeugung und hochauflösender Elektronenmikroskopie untersucht. Die vollständige Struktur bleibt unaufgelöst, jedoch wird angenommen, daß die Struktur aus raum-füllenden polyedrischen Domänen besteht, die sowohl von oktaedrischen als auch von kubischen Ebenen begrenzt werden. Die Periodizität in Richtung der kubischen Ebenen ist in den meisten Fällen wohldefiniert, jedoch variiert der Abstand zwischen den oktaedrischen (111)-Ebenen und die Korrelation zwischen benachbarten Polyedern ist gering.
Two mRNAs Are Transcribed from the Human Gene for Choline Acetyltransferase (1992)

The product of the choline acetyltransferase (ChAT) gene is the enzyme that synthesizes the neurotransmitter acetylcholine. A 14.4-kb portion of the human ChAT gene contains 7 exons, which are estimated to comprise approximately one-third of the human protein coding sequence by comparison with porcine ChAT mRNA. Two of the exons were used to identify polyadenylated human ChAT gene transcripts on Northern blots. An exon with 84% identity to the region of porcine ChAT mRNA that codes for the amino terminus of the corresponding protein detected 6,000- and 2,300-nucleotide mRNAs in RNA isolated from human CHP134 neuroblastoma cells. Only the 2,300-nucleotide mRNA was detected by a second probe containing an exon with 96% identity to porcine ChAT mRNA in the domain that encodes amino acids 204-263 of the predicted porcine ChAT protein. Further evidence that two species of human mRNA are produced from the human ChAT gene was obtained from nuclease protection assays using an antisense RNA probe prepared from a human ChAT cDNA clone. Total RNA isolated from either CHP134 cells or adult human nucleus basalis protected 525- and 400-nucleotide fragments of this probe, confirming the presence of two species of RNA that differ by the inclusion of an internal exon. cDNA clones of each of these transcripts have been isolated. Their sequences suggest that the 2,300-nucleotide mRNA encodes enzymatically active human ChAT, while translation of the 6,000-nucleotide mRNA would be terminated prematurely by a shift in the reading frame. These results indicate that a complex pattern of transcription produces two mRNAs with different coding potentials from the human ChAT gene.
An iridoid glucoside from the leaves of Pavetta crassipes (2019)

An iridoid glucoside, ixoside, was isolated from the leaves of Pavetta crassipes (Rubiaceae), growing in North-Central region of Nigeria. The plant is used in traditional medicine by the people of the locality for the treatment of respiratory disorder and tuberculosis related symptoms. Extraction with methanol followed by chromatographic separation afforded the compound and it was identified on the basis of its UV, IR, MS, 1D and 2D NMR spectral data and comparison to literature reports. The occurrence of an iridoid glucoside in P.crassipes and the genus Pavetta is reported for the first time. Keywords: Pavetta crassipes, Rubiaceae, ixoside, iridoid, spectrophotometry
Aldehyde Biosensor Based on the Determination of NADH Enzymically Generated by Aldehyde Dehydrogenase (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAldehyde Biosensor Based on the Determination of NADH Enzymically Generated by Aldehyde DehydrogenaseF. Pariente, E. Lorenzo, F. Tobalina, and H. D. AbrunaCite this: Anal. Chem. 1995, 67, 21, 3936–3944Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://doi.org/10.1021/ac00117a019Request reuse permissionsArticle Views867Altmetric-Citations175LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (997 KB) Get e-Alertsclose Get e-Alerts
RD-Optimized Rate Shaping for Multiple Scalable Video Streams (2007)

Delivering streaming video over wired and wireless networks poses many challenges, primarily due to the throughput variations caused by time-varying network conditions. Scalable video coding gives an elegant way to adapt the video streams to the available transmission resource. In this paper, we consider a multi-user scenario wherein multiple scalable video streams compete for a shared transmission link with limited forwarding capacity. We propose a rate-distortion (RD) optimized rate shaping approach to improve the overall video quality. For this, compact RD side information is sent along with the sequences. Our simulation results show that significant improvements are achieved by the proposed RD-optimized rate shaping approach compared to conventional priority-based rate shaping.
MQML-Message Queuing Markup Language (2003)

Message Queuing allows applications to use components that communicate with one another using queued messages. In this paper, we propose a Message Queuing Markup Language (MQML), which is an XML based markup language designed to describe e-business applications and enterprise integration. The MQML language is extensible. The detailed description of the MQML is presented in this paper. An research prototype is given to validate the effectiveness and value of our proposed MQML for enterprise integration.
A Case of Pancreatic Pseudocyst Presenting as Duodenal Bleeding (2012)

ì·ì¥ì ê°ì±ë­ì¢ ì ì·ì¥ì¼ì ìíì¬ íí ë°ìíë í©ë³ì¦ì¼ë¡ ëê° ì·ì¥ ë´ë¶ë ì·ì¥ì ì£¼ìì¡°ì§ì ë°ìíë¤. í©ë³ì¦ì¼ë¡ë ê°ì¼, ì£¼ìë´ì¥ì´ë ë³µê° ë´ë¡ì íì´, ëê³µ, ì¥ê´íì, ì¶í ë±ì´ ë°ìíë©°, ê°ì±ë­ì¢ ì ìí ì¶íì ìë¶ìì¥ê´ ì¶íì ëë¬¸ ìì¸ì¤ì íëì´ì§ë§, ìíí í©ë³ì¦ì´ë¤. ì ìë¤ì íë³ì ì£¼ìë¡ ë´ìí ë§ì± ì·ì¥ì¼ íììì ì­ì´ì§ì¥ ì ë§íì¢ ì ì¶íë¡ ì¤ì¸íìë¤ê° ì·ì¥ ê°ì±ë­ì¢ ì´ ì­ì´ì§ì¥ì ì ëë¶ë¥¼ ì¹¨ë²íì¬ ì´ë¡ ì¸í´ ì ë°ë ìë¶ìì¥ê´ ì¶íë¡ ì§ë¨íìì¼ë©°, ë³´ì¡´ì  ì¹ë£ë¡ í¸ì ë 1ìë¥¼ ê²½ííìê¸°ì ë³´ê³ íê³ ì íë¤. ì¤ì¬ ë¨ì´: ì·ì¥ ê°ì±ë­ì¢ ; ì­ì´ì§ì¥; ì¶í
Survey and Evaluation of Neural 3D Shape Classification Approaches (2021)

&lt;div&gt; &lt;div&gt; &lt;div&gt; &lt;p&gt;Classification of 3D objects – the selection of a category in which each object belongs – is of great interest in the field of machine learning. Numerous researchers use deep neural networks to address this problem, altering the network architecture and representation of the 3D shape used as an input. To investigate the effectiveness of their approaches, we conduct an extensive survey of existing methods and identify common ideas by which we categorize them into a taxonomy. Second, we evaluate 11 selected classification networks on three 3D object datasets, extending the evaluation to a larger dataset on which most of the selected approaches have not been tested yet. For this, we provide a framework for converting shapes from common 3D mesh formats into formats native to each network, and for training and evaluating different classification approaches on this data. Despite being generally unable to reach the accuracies reported in the original papers, we can compare the relative performance of the approaches as well as their performance when changing datasets as the only variable to provide valuable insights into performance on different kinds of data. We make our code available to simplify running training experiments with multiple neural networks with different prerequisites. &lt;/p&gt;&lt;p&gt;&lt;b&gt;The final version was published: &lt;a href="https://doi.org/10.1109/TPAMI.2021.3102676"&gt;https://doi.org/10.1109/TPAMI.2021.3102676&lt;/a&gt;&lt;/b&gt;&lt;/p&gt; &lt;/div&gt; &lt;/div&gt; &lt;/div&gt;
Synthesis and Characterization of Layered-Double Hydroxide 3-(4-Hydroxyphenyl) Propionate Nanocomposite (2014)

A new layered-double hydroxide-3-(4-hydroxyphenyl) propionate (LDH-HPP) has been synthesized by intercalation of 3-(4-hydroxyphenyl) propionic acid (HPP) into Zn-Al-layered double hydroxide (LDH) by ion-exchange method. PXRD, FTIR, TGA/DTG, compositional studies and FESEM were used to characterize the synthesized nanocomposite. The intercalation of HPP into the interlayer gallery space of LDH was characterized by x-ray diffractogram showed expanded basal spacing of the value of 17.1 Å. The FTIR spectra of LDH-HPP nanocomposite synthesis by 0.025M HPP resembled a mixture of both FTIR spectra of HPP and LDH. Thermal analysis of LDH-HPP nanocomposite shows a better thermal stability as compared to the pure HPP, which proved that the intercalation of HPP into LDH interlayer enhanced the thermal stability of the HPP.