gebhart/patrepeval huggingface dataset:
Elasticity in Distributed File Systems (2016)

In IaaS Cloud Computing platforms, elasticity offers to users the possibility to adjust the number of resources to the current workload, taking into account peak and trough periods (high and low activity) by powering down/up some resources. In previous work, we solved the challenges raised by the extension of elasticity to storage resources in the context of static data popularities. In this paper, we address the same challenges in the context of dynamic data popularities. We propose 3 solutions that estimate the data popularities, and an algorithm that reduces or increases the number of used server according to the period activity. Based on the platform cost (the resources are paid for the time they are used), our simulations on top of SimGrid show that we could either improve HDFS' performance by up to 99% while providing similar cost, or we could reduce cost up to 50% while providing similar performance.
Learning and Complex Behavior (1993)

Written from the perspective of selectionist theory, this text presents a theoretically integrated approach to the study of animal learning and human cognition that co-ordinates behavioural research and research in neuroscience. It covers traditional topics such as acquisition and extinction of behaviour, stimulus control and schedules of reinforcement, and also deals with topics of student interest such as perception, memory, problem solving and verbal behaviour. All of these topics are discussed in terms of principles established by experimental analysis at the behavioural and neural levels, and scientific interpretation based on those principles.
Effect of synthetic and naturally occurring chalcones on ovarian cancer cell growth: structure-activity relationships. (1995)

This study was carried out to determine the effect of 15 different natural and synthetic chalcones on the proliferation of both established and primary ovarian cancer cells expressing type II oestrogen binding sites (type II EBS). The binding affinity of chalcones for type II EBS was also tested. At concentrations from 0.1 to 10 microM, chalcones inhibited ovarian cancer cell proliferation and [3H]oestradiol ([3H]E2) binding to type II EBS. Considering the structure-related variation in IC50 (concentration resulting in a 50% inhibition of cell growth) and Di50 (concentration resulting in a 50% displacement of [3H]E2 bound to type II EBS), it appeared that the presence of an alpha-beta double bond, the hydroxylation in 3 or 2 of ring B and the absence of a prenyl group were important to both the antiproliferative and binding activity. Structure-related variations in IC50 and Di50 were significantly concordant (Fisher's exact test: P = 0.0291), suggesting that there may be a type II EBS-mediated mechanism for chalcone antiproliferative activity. Our data indicate that chalcones could be considered as potential new anticancer drugs.
Invasion of mouse erythrocytes by the human malaria parasite, Plasmodium falciparum. (1987)

Plasmodium falciparum malaria merozoites require erythrocyte sialic acid for optimal invasion of human erythrocytes. Since mouse erythrocytes have the form of sialic acid found on human erythrocytes (N-acetyl neuraminic acid), mouse erythrocytes were tested for invasion in vitro. The Camp and 7G8 strains of P. falciparum invaded mouse erythrocytes at 17-45% of the invasion rate of human erythrocytes. Newly invaded mouse erythrocytes morphologically resembled parasitized human erythrocytes as shown on Giemsa-stained blood films and by electron microscopy. The rim of parasitized mouse erythrocytes contained the P. falciparum 155-kD protein, which is on the rim of ring-infected human erythrocytes. Camp but not 7G8 invaded rat erythrocytes, indicating receptor heterogeneity. These data suggest that it may be possible to adapt the asexual erythrocytic stage of P. falciparum to rodents. The development of a rodent model of P. falciparum malaria could facilitate vaccine development.
Stirring the porphyrin alphabet soup—functionalization reactions for porphyrins (2011)

Advances in the synthesis of unsymmetrically meso substituted porphyrins are based on the development of new total syntheses and porphyrin functionalization methods. These methods have replaced earlier mixed condensation reactions and give synthetic access to almost any desired meso-substituted porphyrin. They include the complete series of porphyrin homologues and regioisomers of the A(x)-series with either alkyl or aryl residues, and numerous examples of ABCD-type chromophores. The syntheses are based on a combination of classic functionalization reactions, the use of organolithium reagents in S(N)Ar reactions, and organometallic reactions with Pd, Ni, Cr, Ru, B, and Sn catalysis. This feature article gives an account of our work in the past decade to develop synthetic methods for the A(x)- and ABCD-type porphyrins and their use as optical materials and photosensitizers.
Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae (1996)

To identify mutations that cause defects in mitosis, a collection of mutants in Saccharomyces cerevisiae was screened by a rapid visual assay for abnormal chromosome segregation. From this screen we identified one mutation, pds1-1 that was independently identified in an alternative screen for mutants that exhibit inviability after transient exposure to nocodazole and precocious disassociation of sister chromatids (Guacci, V., A. Yamamoto, A. Strunnikov, J. Kingsbury, E. Hogan, P. Meluh, and D. Koshland. 1993. CSH Symp. Quant. Biol. 58:677-685; Yamamoto, T.J., G. Li, B. Schaar, I. Szilak, and D.W. Cleveland. 1992. Nature (Lond.). 359:536-539). At 23 degrees C pds1-1 mutants exhibit frequent cell death and a 300-fold increase in chromosome loss compared to wild type. At 37 degrees C pds1-1 cells fail to elongate their spindles during anaphase. This spindle defect of pds1 mutants results from a temperature-sensitive step that occurs around the G1/S boundary about the time of spindle assembly. In the absence of spindle elongation pds1 mutants undergo cytokinesis, leading to the missegregation of both chromosomes and spindle pole bodies. After abnormal cell division pds1-1 mutants also initiate new rounds of DNA replication, spindle pole body duplication, and bud formation. Thus, in the pds1-1 mutant at 37 degrees C, cell cycle progression is uncoupled from the completion of anaphase. A pds1 deletion allele has similar phenotypes to the original allele. Taken together these results suggest that Pds1 protein plays an important role in chromosome segregation at 23 degrees C and an essential role for this process at 37 degrees C. The PDS1 gene encodes a novel 42-kD nuclear protein that has both basic and acidic domains. The level of PDS1 mRNA varies with the cell cycle with maximal accumulation around the G1/S boundary. The stability of Pds1 protein also appears to change during the cell cycle as overproduced Pds1p is stable in S and M but degraded in early G1. Therefore, expression of Pds1p is regulated apparently both transcriptionally and postranslationally during the cell cycle. The phenotypes of pds1 mutants and expression pattern of Pds1p are discussed in the context of other spindle-defective mutants and the knowledge that Pds1 protein is an inhibitor of anaphase (Yamamoto, T.J., G. Li, B. Schaar, I. Szilak, and D.W. Cleveland. 1992. Nature (Lond.). 359:536-539).
Subtractive NCE‐MRA: Improved background suppression using robust regression‐based weighted subtraction (2020)

Weighted subtraction using RR was able to acquire the regression coefficients of background signal and improve background suppression of subtractive non-contrast-enhanced MR angiography techniques. RR deviation angle has the most robust and accurate overall performance among three regression methods.
Multi-path Intelligent Planning Method Based on Grid Division and Value Calculation (2018)

For agricultural products and fast-moving consumer goods companies, the realities of too many retail terminals and limited human resources are the main problems faced by market visit tasks. Therefore, planning multiple paths for the sales man to obtain higher commercial value is a concern of the company. In this paper, for reducing the scale of data calculations, the large dataset is divided into several small datasets by meshing method, and then the path planning operation is conducted in the divided small datasets. Two path planning methods are proposed in this paper, Point’s distance-first path traversal method (PDF) and Point’s value-first path recursive method (PVF). Experiments show that algorithm PDF gives the distribution of points in the path is more intensive and the overall length of the path is shorter. And algorithm PVF gives the distribution of points in the path is more dispersed and the total value is higher.
Wnt5a Inhibits Human Monocyte‐Derived Myeloid Dendritic Cell Generation (2013)

Wnt5a is a non-canonical Wnt protein that is expressed at elevated levels in inflammatory conditions. Its role in inflammation remains unclear, although it is known that Wnt5a is expressed at a higher level in monocyte-derived myeloid dendritic cells (Mo-mDCs) than in monocytes and macrophages. The function of Wnt5a in dendritic cells (DCs) remains relatively unexplored. Here, we found that under Mo-mDC culture conditions, Wnt5a inhibited the generation of CD14(⁺/low) Mo-mDCs while promoting the generation of CD14⁺/⁺⁺ CD16⁺ monocytes. We could further show that stimulation of monocytes with rWnt5a induced a rapid IL-6 production and that the rWnt5a treated Mo-mDC differentiation was restored upon blocking of IL-6. Also, conditioned media from Wnt5a stimulated human breast cancer cells producing IL-6, specifically inhibited Mo-mDC differentiation. These observations are strengthened by our finding that patients with sepsis, a disease involving elevated Wnt5a and IL-6 levels, also showed a significant increase in the CD14⁺ CD16⁺⁺/CD14⁺/⁺⁺ CD16⁺ monocyte populations, which was accompanied by a significant decrease in circulating mDCs. We finally show that under typical Mo-mDC culture conditions, monocytes isolated from patients with sepsis as compared to healthy controls, preferentially differentiated into CD14CD14⁺/⁺⁺ HLA-DR⁺⁺ cells. We suggest that Wnt5a is a possible candidate mediator for the CD14⁺/⁺⁺ CD16⁺ monocyte accumulation seen in patients with infectious disease and cancer.
Fabric filters for the electric utility industry (1988)

This publication is the fifth in a series presenting results of EPRI's research and development work applying baghouse technology to the collection of particulate matter at coal-fired electric power generating plants. The series, Fabric Filters for the Electric Utility Industry,'' is intended as a practical, hands-on reference for plant operators, engineers and home office managers. Multiple volumes were planned, each to be produced sequentially over the period 1987--1992. Topics that are addressed include operating principles and terminology, baghouse design considerations, bags and fabrics, flue gas dynamics, reverse-gas cleaning, reverse-gas cleaning with sonic assistance, shake/deflate cleaning, pulse-jet cleaning, combined SO[sub 2] collection, and operation and maintenance. Volume 5, Guidelines for Fabric Filter Design, is intended as a guide for electric utilities assessing the application of fabric filters for particulate matter control from coal-fired utility boilers. This guideline describes how baghouses function, provides data that can be used to project performance for different coals and boilers, and reviews key design considerations. A step-by-step approach is included that will assist the utility engineer evaluate the potential applicability for a specific situation and specify the proper baghouse design. This report focuses on low-ratio (reverse-gas with or without sonic assist, shake-deflate) baghouses in PC applications.more » Baghouse performance for other types of boilers are discussed where data are available. Pulse-jet baghouses, an increasingly attractive particulate control option for utilities, will be discussed in future volumes.« less
Mechanical stress-induced mast cell degranulation activates TGF-β1 signalling pathway in pulmonary fibrosis (2019)

This study suggests that mast cells may contribute to the progression of pulmonary fibrosis.
Analysis of apoptosis by propidium iodide and fluorescein diacetate (2007)

U poglavlju je opisana tehnika određivanja stanicne smrti bojanjem stanica s propidij jodidom i fluorescein diacetatom
ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors (2022)

The extracellular aggregation of destabilized transthyretin (TTR) variants is implicated in the onset and pathogenesis of familial TTR-related amyloid diseases. One strategy to reduce the toxic, extracellular aggregation of TTR is to decrease the population of aggregation-prone proteins secreted from mammalian cells. The stress-independent activation of the unfolded protein response (UPR)-associated transcription factor ATF6 preferentially decreases the secretion and subsequent aggregation of destabilized, aggregation-prone TTR variants. However, the mechanism of this reduced secretion was previously undefined. Here, we implement a mass-spectrometry-based interactomics approach to identify endoplasmic reticulum (ER) proteostasis factors involved in ATF6-dependent reductions in destabilized TTR secretion. We show that ATF6 activation reduces amyloidogenic TTR secretion and subsequent aggregation through a mechanism involving ER retention that is mediated by increased interactions with ATF6-regulated ER proteostasis factors including BiP and PDIA4. Intriguingly, the PDIA4-dependent retention of TTR is independent of both the single TTR cysteine residue and the redox activity of PDIA4, indicating that PDIA4 retains destabilized TTR in the ER through a redox-independent mechanism. Our results define a mechanistic basis to explain the ATF6 activation-dependent reduction in destabilized, amyloidogenic TTR secretion that could be therapeutically accessed to improve treatments of TTR-related amyloid diseases.
Red Sea Sponges of the Genus Hyrtios as a Source of Symbiotic Fungi with Antimicrobial Activities (2017)

The diversity of the symbiotic fungi associated with two Red Sea sponges of the genus Hyrtios (H. erecta and H. erectus) was investigated. A total of 20 isolates were purified from these sponges. Using the morphological properties, 10 fungal strains were identified to the genus level from each sponge. Strains isolated from H. erecta were identified to the species level using the Internal Transcribed Spacer ITS-rDNA sequences. Most of the identified fungal strains belong to the genera Penicillium and Aspergillus. The antibacterial activities of organic extracts of these fungi were investigated against three pathogenic microbes including E. coli, S. aureus and C. albicans. All of the fungal extracts displayed moderate to high levels of antimicrobial activities against the three pathogens. Several fungal strains of the genera Penicillium and Aspergillus displayedstrong antibacterial activities provide potential for future investigation of these strains to identify the bioactive leads in these fungal extracts.
Measurement of Tool Temperature Using Thermal Imaging in Interrupted Cut Turning (2009)

The creation of oscillating tool paths for turning operations that use the numerically controlled machine axes to ensure reliable chip breaking has been demonstrated in a variety of materials. The interrupted cuts created in this way have the additional benefit of allowing the temperature of the tool-chip interface to be controlled at a significantly lower level than in conventional turning. In traditional continuous turning, the interface temperature rises to a high level and stays there during machining. This is especially a problem for difficult-to-machine materials, because many tool wear mechanisms are strongly temperature dependent. In the chip breaking tool paths, the axes of the machine are used to oscillate the tool along the programmed tool path and before the temperature has a chance to rise to damaging levels, the cut can be interrupted so that the tool can cool. This is analogous to the technique of using shallow radial depths of cut in milling operations for difficult-to-machine materials. In this work, a thermal imaging camera is used to verify that this strategy can be effective in the machining of steel. The results from the thermal imaging studies show that over a broad range of conditions, oscillating tools paths create lower temperatures at the tool-chip interface.
Potato skin proteome is enriched with plant defence components (2008)

Periderm is a tissue of secondary origin that replaces damaged epidermis. It can be found in underground plant organs, as an above-ground tissue of woody species (cork), and as a wound-healing tissue. Its outer layers are composed of phellem cells with suberized walls that constitute a protective barrier, preventing pathogen invasion and fluid loss. In potato, a model for periderm studies, periderm tissue replaces the epidermis early in tuber development and the suberized phellems constitute the tuber's skin. To identify factors involved in phellem/skin development and that play a role in its defensive characteristics, two-dimensional gel electrophoresis was used to compare the skin and parenchymatic flesh proteomes of young developing tubers. Proteins exhibiting differentially high signal intensity in the skin were sorted by functional categories. As expected, the differential skin proteome was enriched in proteins whose activity is characteristic of actively dividing tissues such as cell proliferation, C(1) metabolism, and the oxidative respiratory chain. Interestingly, the major functional category consisted of proteins (63%) involved in plant defence responses to biotic and abiotic stresses. This group included three isozymes of caffeoyl-CoA O-methyltransferase and five isozymes of peroxidase that may play a role in suberization processes. The differential expression of these proteins in the skin was further verified by RT-PCR of their corresponding transcripts in skin and tuber flesh samples. The results presented here shed light on the early events in skin development and further expand the concept of the periderm as a protective tissue containing an array of plant defence components.
A distributed, energy-efficient and QoI-aware framework for in-network processing (2014)

In-network processing (INP) is a promising method that allows aggregation of data while it is being transferred along the communication paths as a means to optimize the utilization of network resources without violating the quality of information (QoI) requirements. Given the large amount of data existing in dynamic environments, the optimization of INP requires a distributed framework that can adapt easily to network changes and user requirements. In this work, we develop the principle for designing a distributed mechanism in order to determine and control INP. Specifically, the proposed framework can decide, in a distributed way, which nodes along the communication paths optimally perform INP, with consideration of operational energy consumption and QoI requirements for achieving global optimal INP. The significance of the proposed distributed method is that it requires each node to make independent decisions locally for data aggregations, thus naturally enhance robustness and efficiency against network and data load dynamics. Extensive numerical results are presented to confirm the validity of the proposed approach.
Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study (2021)

Selective P2X3 antagonism with eliapixant significantly reduced cough frequency and severity, confirming this as a viable therapeutic pathway for RCC. Taste-related side-effects were lower at therapeutic doses than with the less selective P2X3 antagonist gefapixant. Selective P2X3 antagonism appears to be a novel therapeutic approach for RCC.
A molecular cation channel (1982)

Abstract A polymer of an isocyanide, [RNC&lt;] n has been synthesized in which R contains a benzo‐18‐crown‐6 group. The crown ether rings are situated on top of each other and form channels which bind metal ions.
Pharmacokinetic/Pharmacodynamic Feedback Modelling of the Functional Corticosterone Response in Rats after Acute Treatment with Escitalopram (2007)

The objective of this study was to characterize the pharmacokinetic/pharmacodynamic (PK/PD) relationship of the drug-induced corticosterone response after administration of escitalopram in rats. To achieve this, a mechanistic feedback turnover model mimicking the acute mechanism of action of selective serotonin reuptake inhibitors was assessed. Conscious and freely moving rats received constant rate infusions of 2.5, 5 or 10 mg/kg escitalopram or vehicle over 60 min. Automated serial blood sampling was conducted to determine escitalopram and corticosterone concentrations. The PK/PD model consisted of a turnover model of escitalopram-evoked changes in response, which included an inhibitory feedback moderator function. Accordingly, response acted linearly on the production (k(tol)) of the moderator, which acted inversely on the production (k(in)) of response. The escitalopram plasma kinetics served as input to an inhibitory function acting on the loss (k(out)) of response. The corticosterone responses were successfully described using the model by fitting responses from all doses simultaneously resulting in estimation of drug parameters (I(max), IC(50) and n) in addition to system parameters (k(in), k(out) and k(tol)) for the whole exposure range. Thus, the applicability of the model for analysis of the acute selective serotonin reuptake inhibitor-induced corticosterone response including acute auto-inhibitory feedback was demonstrated.
Reduction of Aldehydes with Aluminum Isopropoxide1,2 (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduction of Aldehydes with Aluminum Isopropoxide1,2William G. Young, Walter H. Hartung, and Frank S. CrossleyCite this: J. Am. Chem. Soc. 1936, 58, 1, 100–102Publication Date (Print):January 1, 1936Publication History Published online1 May 2002Published inissue 1 January 1936https://pubs.acs.org/doi/10.1021/ja01292a033https://doi.org/10.1021/ja01292a033research-articleACS PublicationsRequest reuse permissionsArticle Views728Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts