gebhart/patrepeval huggingface dataset:
Intermolecular Fructosyl and Levanbiosyl Transfers by Levan Fructotransferase of Arthrobacter ureafaciens (1985)

A purified levan fructotransferase preparation from the culture of the bacterium Arthrobacter ureafaciens, which produces di-D-fructose 2,6':6,2' dianhydride (difructose anhydride IV) from levan by an intramolecular levan fructosyl transfer (ILFT) reaction, was found to produce a trioligofructan and a tetraoligofructan from levan in the presence of levanbiose, indicating the intermolecular fructosyl and levanbiosyl transfer (LFT and LBT) reactions. The tri- and tetraoligofructans were identified to be levantriose and -tetraose respectively. Increase in the levanbiose concentration brought about increased production of both oligofructans with decreased formation of difructose anhydride IV, supporting the previous theory proposed by Tanaka et al. (1983) that the ILFT, LFT, and LBT reactions are catalyzed by the same enzyme. In addition, there existed a roughly stoichiometric relationship between the increase and decrease in the productions of these oligofructans, and the LBT reaction was found to occur more intensively than the LFT reaction. Acceptor specificity of the LFT and LBT reactions was studied using fifteen sugars including mono-, di-, and trisaccharides. The enzyme showed both of the reactions only with levanbiose, -triose, and kestose, indicating that the exposed non-reducing levanbiosyl residue was essential for the acceptor and suggesting the existence of a levanbiosyl acceptor site on the enzyme molecule.
Catheter for endoluminal bipolar electrocoagulation. (1989)

An interventional catheter was designed that can induce controlled endoluminal tissue lesions by means of bipolar radio-frequency (RF) electrocoagulation under fluoroscopic guidance. The technique was used to obtain safe and reproducible percutaneous occlusion of the porcine cystic duct by reactive endoluminal scar formation. The new triple-lumen, 7-F, polyethylene catheter contains two insulated active wires and accommodates a 0.038-inch steerable guide wire, which facilitates insertion and placement of the active catheter tip under fluoroscopic control. The coagulation technique is relatively simple and requires only a small, portable bipolar RF generator and ammeter.
Nuclear orientation of praseodymium 142 (1958)

To test whether polarization of Pr/sup 143/ was likely to be obtained, experiments have been carried out on the neighboring 19-hr isotope Pr/sup 142/ whose orientation can be detected and measured by observation of its gamma radiation. A single crystal of cerium magnesium nitrate was grown from solution containing Pr/sup 142/, and this was mounted in the demagnetization cryostat: it was estimated that about 0.5% of the Ce/sup 3+/ ions had becn replaced by Pr/sup 3+/. The crystal was then cooled by adiabatic demagnetization, and the gamma - ray anisotropy waa measured as a function of temperature in zero field. (W.D.M.)
A case of indolent AML with five-year survival without treatment (2017)

"A case of indolent AML with five-year survival without treatment." Leukemia & Lymphoma, 59(2), p. 519
Nucleotide sequence of the glycoprotein S gene of bovine enteric coronavirus and comparison with the S proteins of two mouse hepatitis virus strains (1990)

The gene encoding the spike glycoprotein (S) of bovine enteric coronavirus (BECV) was cloned and its complete sequence of 4092 nucleotides was determined. This sequence contained a single long open reading frame with a coding capacity of 1363 amino acids (Mr 150,747). The predicted protein had 19 N-glycosylation sites. A signal sequence comprising 17 amino acids was observed starting from the first methionine residue. A potential peptidase cleavage site was located between amino acids 763 and 767. These cleavage explain the maturation of the primary product of the S gene to S1 (Mr 104,692) and S2 (Mr 84,175) spike structural proteins. Two amphipathic alpha-helices (amino acids 1007 to 1077 and 1269 to 1294) which may constitute the 12 nm stalk of the viral spike were also observed; another alpha-helix (amino acids 1305 to 1335) may be involved in the anchorage of the spike in the viral membrane. Comparison of this protein sequence to the described homologous mouse hepatitis (MHV) strain A59 and MHV-JHM S protein sequences led us to suggest that MHV-A59 and MHV-JHM S genes could be derived from a deletion of the BECV S gene.
Congo (1989)

The ethnic classifications selected for Congo as well as being based on cultural criteria, are based on locally recognized identity groups. The Kongo grouping, which constitutes nearly half the total population, is a broad group of culturally similar peoples who have historically come under the dominance of the Kongo kingdom and who speak Kikongo. They are also an important group in Zaire and Angola. It should be noted that the numerically and politically significant Lali (or Lari), although considered a Kongo group today, are of Téké origin and have formerly been classified as such. In addition to the major groups there are also Eshira peoples (4 percent), Maka (3 percent), and Kota (1 percent). Scattered Pygmy populations exist in the north. (Note: the term “M’bochi” is used in Congo census reports, but is not used by Murdock.) There were 8,000 French nationals resident in the Congo in 1977 (0.6 percent of the population.)
Oncologic outcomes in patients with radiation associated rectal adenocarcinoma. (2023)

e15529 Background: The rectal wall is often irradiated during pelvic radiotherapy for prostate cancer, potentially increasing the risk of rectal adenocarcinoma. The oncologic outcomes of rectal adenocarcinoma in previously irradiated patients remain largely unknown. Methods: We performed a retrospective analysis of patients with stage I-IV rectal adenocarcinoma after radiotherapy for prostate cancer (RCRPC). Clinical characteristics and treatment were compared to a background set of patients with rectal cancer not associated with prostate cancer (RCNAPC). We investigated the differences in survival using propensity score matching (1:1 ratio). Patients were matched based on stage, tumor size, distance from anal verge and circumferential tumor location, but were unable to be matched on age. Five-year disease-free survival (DFS), overall survival (OS), local recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) were visualized using Kaplan-Meier curves and statistical significance was assessed using log-rank tests. Results: The study included 66 RCRPC patients treated with prostate brachytherapy (n = 19), external beam radiation therapy (n = 31) or both (n = 16). The median latency period between the completion of prostate radiotherapy and the diagnosis of rectal cancer was 11.7 years. The median follow-up from rectal cancer diagnosis was 2.4 years. The median prostate radiation dose was 74 Gy. Compared to the 609 RCNAPC patients, the RCRPC group was older (median 78 vs 55 years, P &lt; 0.001) and more likely to be stage I (24% vs 5%, P &lt; 0.001). Tumors were more frequently found within the distal rectum (47% vs 22%, P &lt; 0.001) and along the anterior rectal wall (33% vs 11%, P &lt; 0.001). Patients in the RCRPC group were less likely to receive neoadjuvant chemotherapy (50% vs. 93%, P &lt; 0.001), neoadjuvant radiation (21% vs 85%, P &lt; 0.001), or undergo surgery (54% vs 61%, P &lt; 0.001) compared to the RCNAPC group. The oncologic outcomes for the RCRPC group and matched cohort of patients with RCNAPC are presented in table 1. Conclusions: Patients with radiation associated rectal cancer have earlier stage tumors but show higher rates of distant metastasis and lower survival compared to nonirradiated patients. They are older and less likely to receive chemotherapy or radiation and are often poor candidates for radical surgery. Whether the worse outcomes are attributable to differences in patient characteristics, available treatment options or a more aggressive biology remains unknown. [Table: see text]
Equine Malignant Lymphomas: Morphologic and Immunohistochemical Classification (1998)

Gross lesions, microscopic appearance, and immunophenotyping are reported in a retrospective study of 31 cases of equine malignant lymphoma. Immunohistochemical studies were performed on archived formalin-fixed, paraffin-embedded tissues. Monoclonal antibodies to surface glycoprotein BLA.36 and intracytoplasmic domains of mb-1 and B29 were used to document the presence of B lymphocytes in the equine tumors. Polyclonal antibody to CD3 and monoclonal antibodies to T-lymphocyte markers CD3 and CD5 revealed the presence of variable numbers of T cells within the equine lymphomas. The neoplastic component of the equine lymphomas was determined through morphologic evaluation, immunophenotyping, and the use of proliferation markers Ki-67 and proliferating cell nuclear antigen. Equine malignant lymphomas were composed of a heterogeneous cell population. Most tumors contained B and T lymphocytes. Twenty-four horses had diffuse lymphomas derived from B lymphocytes. Thirteen of these lymphomas contained primarily neoplastic B lymphocytes. Eleven additional cases of diffuse large B-cell lymphoma contained from 40% to 80% nonneoplastic T lymphocytes and were classified as T-cell-rich, large B-cell lymphomas. This is the first description of T-cell-rich, B-cell lymphoma in the horse. Six tumors with a diffuse architecture were derived from T lymphocytes. Four T-cell tumors were large-cell tumors, 1 was a small-cell tumor, and in 1 tumor the size of the cells could not be determined accurately because of autolytic change in the tissues. One diffuse large-cell lymphoma did not react with either B- or T-cell markers.
A simple DTC-SVM method for matrix converter drives using a deadbeat scheme (2005)

In this paper, a simple direct torque control (DTC) method for sensorless matrix converter drives is proposed, which is characterized by a simple structure, minimal torque ripple and unity input power factor. Also a good sensorless speed-control performance in the low speed operation is obtained, while maintaining constant switching frequency and fast torque dynamics. It is possible to combine the advantages of matrix converters with the advantages of the DTC strategy using space vector modulation a deadbeat algorithm in the stator flux reference frame. Experimental results are shown to illustrate the feasibility of the proposed strategy.
Nothing Is Irrelevant in a Noisy World: Sensory Illusions Reveal Obligatory within-and across-Modality Integration (2012)

In the "flash-beep illusion," a single light flash is perceived as multiple flashes when presented in close temporal proximity to multiple auditory beeps. Accounts of this illusion argue that temporal auditory information interferes with visual information because temporal acuity is better in audition than vision. However, it may also be that whenever there are multiple sensory inputs, the interference caused by a to-be-ignored stimulus on an attended stimulus depends on the likelihood that the stimuli are perceived as coming from a single distal source. Here we explore, in human observers, perceptual interactions between competing auditory and visual inputs while varying spatial proximity, which affects object formation. When two spatially separated streams are presented in the same (visual or auditory) modality, temporal judgments about a target stream from one direction are biased by the content of the competing distractor stream. Cross-modally, auditory streams from both target and distractor directions bias the perceived number of events in a target visual stream; however, importantly, the auditory stream from the target direction influences visual judgments more than does the auditory stream from the opposite hemifield. As in the original flash-beep illusion, visual streams weakly influence auditory judgments, regardless of spatial proximity. We also find that perceptual interference in the flash-beep illusion is similar to within-modality interference from a competing same-modality stream. Results reveal imperfect and obligatory within- and across-modality integration of information, and hint that the strength of these interactions depends on object binding.
Characterization of improved Capacitive Micromachined Ultrasonic Transducers (CMUTS) using ALD high-&#x039A; dielectric isolation (2014)

Use of high-κ dielectric, atomic layer deposition (ALD) hafnium oxide (HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) as an isolation layer material is demonstrated as an improvement over traditional plasma enhanced chemical vapor deposition (PECVD) silicon nitride (Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> ) for Capacitive Micromachined Ultrasonic Transducers (CMUTs) fabricated by a low temperature, CMOS compatible, sacrificial release method. ALD HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> dielectric properties are characterized to optimize CMUT design. Performance improvements are evaluated through parallel plate modeling which showed high gains especially for vacuum gaps of 50 nm and below. Experiments are performed on parallel fabricated test CMUTs with 50 nm gap and 16.5 MHz center frequency to measure and compare pressure output and receive sensitivity for both materials. Results show 6 dB improvement in receive sensitivity (Pa/V) with the collapse voltage reduced by one half, while in transmit mode, half the input voltage is needed to achieve the same maximum output pressure, both as predicted by the models.
Co-designing with office workers to reduce energy consumption and improve comfort (2015)

According to the EC Action Plan for Energy Efficiency, a reduction of up to 30% in energy use within the office and commercial building sector can be achieved through occupant behavior change. Multiple studies support similar estimations for countries outside of the EU (e.g. Lopes et al. 2011). Depending on the building type, office occupants can perform various low energy actions to increase office comfort (e.g. Barlow &amp; Fiala, 2007). However, sustained behavior change ensuring energy-efficiency may be difficult when not embedded and enforced in everyday office practices.\n This paper describes an approach based on co-creation methods as a means to engage office occupants to make them conscious of the impact that their actions have on comfort and energy use by reflecting on results from measurements and observations. Methods to create awareness include co-designing of a monitoring platform, self-reporting mechanisms and feedback systems, enabled by modular hardware and an adaptable software platform. Through the co-design process supported by engineers and designers, occupants define ways of how sensor monitoring, self-reporting and feedback displays can be introduced into their office environments to stimulate and guide their energy-efficient and comfort-efficient actions in the context of everyday office practices.\n The co-design approach is currently being deployed and evaluated in an ongoing study, which is being conducted in three large office buildings, each involving an experimental and a control group. Co-design workshops have demonstrated the value of involving office workers in exploring how best to involve stakeholders across various functions in the organizations. Office occupants were found to be particularly motivated towards improving comfort, which can act as a pathway to shaping energy behavior.
Detection of pre-microRNA with Convolutional Neural Networks (2019)

MicroRNAs (miRNAs) are small non-coding RNA sequences that have been implicated in many physiological processes and diseases. The experimental discovery of miRNAs is complicated because both miRNAs and their targets need to be expressed for the confirmation of functional interactions, but expression is under spatiotemporal control. This has motivated the development of computational methods for miRNA detection. This typically involves feature design by domain experts followed by machine learning. While handcrafted features can encode domain knowledge, feature engineering is a time-consuming task. Additionally, some of the currently most successful features for pre-miRNA detection, such as p-value based ones, require comparably large computations. In contrast, advances of representation learning methods such as deep learning can discover relevant features directly from data. Here, we propose a method that uses domain knowledge to create an efficient graphical representation of pre-miRNAs, encoding sequence, structure, and implicitly some thermodynamic information. A suitable convolutional neural network architecture for pre-miRNA detection was used to train a model. This model achieves state-of-the-art performance on all previously used datasets. Additionally, computations succeed in real time thereby overcoming current speed limitations. Finally, our strategy promises future interpretability of the trained models and in turn novel biological interpretations of pre-miRNA characteristics.
Relative localization of RFID tags using spatial-temporal phase profiling (2015)

Many object localization applications need the relative locations of a set of objects as oppose to their absolute locations. Although many schemes for object localization using Radio Frequency Identification (RFID) tags have been proposed, they mostly focus on absolute object localization and are not suitable for relative object localization because of large error margins and the special hardware that they require. In this paper, we propose an approach called Spatial-Temporal Phase Profiling (STPP) to RFID based relative object localization. The basic idea of STPP is that by moving a reader over a set of tags during which the reader continuously interrogating the tags, for each tag, the reader obtains a sequence of RF phase values, which we call a phase profile, from the tag's responses over time. By analyzing the spatial-temporal dynamics in the phase profiles, STPP can calculate the spatial ordering among the tags. In comparison with prior absolute object localization schemes, STPP requires neither dedicated infrastructure nor special hardware. We implemented STPP and evaluated its performance in two real-world applications: locating misplaced books in a library and determining baggage order in an airport. The experimental results show that STPP achieves about 84% ordering accuracy for misplaced books and 95% ordering accuracy for baggage handling.
Metallocene Antimalarials: The Continuing Quest (2007)

Over the last decade, a significant body of research has been developed around the inclusion of a metallocene moiety into known antimalarial compounds. Ferroquine is the most successful of these compounds. Herein, we describe our contribution to metallocene antimalarials. Our approach has sought to introduce diversity sites in the side chain of ferroquine in order to develop a series of ferroquine derivatives. The replacement of the ferrocenyl moiety with ruthenocene has given rise to ruthenoquine and a modest series of analogues. The reaction of ferroquine and selected analogues with Au(PPh3)NO3, Au(C6F5)(tht), and [Rh(COD)Cl2] has resulted in a series of heterobimetallic derivatives. In all cases, compounds have been evaluated for in vitro antiplasmodial activity in both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. Preliminary structure-activity relationships have been delineated.
Evaluation of EarthCARE Cloud Profiling Radar Doppler Velocity Measurements in Particle Sedimentation Regimes (2013)

Abstract The joint European Space Agency–Japan Aerospace Exploration Agency (ESA–JAXA) Earth Clouds, Aerosols and Radiation Explorer (EarthCARE) mission is scheduled for launch in 2016 and features the first atmospheric Cloud Profiling Radar (CPR) with Doppler capability in space. Here, the uncertainty of the CPR Doppler velocity measurements in cirrus clouds and large-scale precipitation areas is discussed. These regimes are characterized by weak vertical motion and relatively horizontally homogeneous conditions and thus represent optimum conditions for acquiring high-quality CPR Doppler measurements. A large dataset of radar reflectivity observations from ground-based radars is used to examine the homogeneity of the cloud fields at the horizontal scales of interest. In addition, a CPR instrument model that uses as input ground-based radar observations and outputs simulations of CPR Doppler measurements is described. The simulator accurately accounts for the beam geometry, nonuniform beam-filling, and signal integration effects, and it is applied to representative cases of cirrus cloud and stratiform precipitation. The simulated CPR Doppler velocities are compared against those derived from the ground-based radars. The unfolding of the CPR Doppler velocity is achieved using simple conditional rules and a smoothness requirement for the CPR Doppler measurements. The application of nonuniform beam-filling Doppler velocity bias-correction algorithms is found necessary even under these optimum conditions to reduce the CPR Doppler biases. Finally, the analysis indicates that a minimum along-track integration of 5000 m is needed to reduce the uncertainty in the CPR Doppler measurements to below 0.5 m s−1 and thus enable the detection of the melting layer and the characterization of the rain- and ice-layer Doppler velocities.
Physical compatibility of antithymocyte globulin (rabbit) with heparin sodium and hydrocortisone sodium succinate (2003)

Journal Article Physical compatibility of antithymocyte globulin (rabbit) with heparin sodium and hydrocortisone sodium succinate Get access Lawrence A. Trissel, B.S.PHARM., Lawrence A. Trissel, B.S.PHARM. Director Clinical Pharmaceutics Research, Division of Pharmacy, The University of Texas M. D. Anderson Cancer Center, Houston Address correspondence to Mr. Trissel at the Division of Pharmacy, Unit 90, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030. Search for other works by this author on: Oxford Academic Google Scholar Christopher A. Saenz Christopher A. Saenz Pharmacy Technician Clinical Pharmaceutics Research, Division of Pharmacy, The University of Texas M. D. Anderson Cancer Center, Houston Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 60, Issue 16, 15 August 2003, Pages 1650–1652, https://doi.org/10.1093/ajhp/60.16.1650 Published: 15 August 2003