gebhart/patrepeval huggingface dataset:
240 Impact and Outcomes of a Weekend Screening Colonoscopy Program in a Large Health Network in Western Pennsylvania (2019)

INTRODUCTION: Colorectal cancer screening remains underutilized with 66–67% of adults 50–75 years old being up to date with screening. The National CRC Roundtable and the ACG aimed to increase screening rates to 80% by 2018. To achieve this goal, screening colonoscopy was provided on Saturdays to improve access and provide for patients who could not take a day off of work. We evaluated the impact of improved access to colonoscopy through Saturday screenings. METHODS: In March 2018, Fall 2018, March 2019, colonoscopies were scheduled with 28 different providers on 12 Saturdays at 8 different sites. Patients were asked to complete a brief survey to capture demographics and reasons for choosing a Saturday for their colonoscopy. Pathology results and adenoma detection rates were collected and analyzed 1 week after procedure. RESULTS: 220 colonoscopies were scheduled and 214 procedures performed with 6 no-show/cancellations. 207 surveys were completed. Public awareness for Saturday colonoscopies was provided through our Network hospital and healthcare insurance provider websites as well as physician practices, and social media. The mean age of participants was 55 years with the majority being Caucasian and female. Post procedure results were analyzed for the number and size of polyps, polyp pathology, and resultant surveillance intervals. Of the 207 procedures, 37.7% (n = 78) of patient has at least one adenoma. Figure 1 shows breakdown of adenoma type by number of patients. Surveillance intervals changed to 5, 3 and 1 year for 37% (n = 76), 14% (n = 30), and 3% (n = 6) of patients, respectively (Figure 2). We also found that 86% of patients were more likely to complete their colonoscopy if scheduled on a Saturday. 42% indicated that the major reason for delay in scheduling was inability to take a day off of work (Table 1). CONCLUSION: The impact of Saturday colonoscopies within our large Network and surrounding community is evidenced by the overwhelming response that patients would be more likely to complete their screening colonoscopy on a Saturday, if offered. The convenience of non-traditional Saturday scheduling provides substantial positive impact in our mission to improve colorectal cancer screening rates in Western Pennsylvania and to provide high quality care as well as with improved patient experience.
Kaleido: Network Traffic Attribution using Multifaceted Footprinting (2014)

Network traffic attribution, namely, inferring users responsible for activities observed on network interfaces, is one fundamental yet challenging task in network security forensics. Compared with other user-system interaction records, network traces are inherently coarsegrained, context-sensitive, and detached from user ends. This paper presents Kaleido, a new network traffic attribution tool with a series of key features: a) it adopts a new class of inductive discriminant models to capture user- and context-specific patterns (“footprints”) from different aspects of network traffic; b) it applies efficient learning methods to extracting and aggregating such footprints from noisy historical traces; c) with the help of novel indexing structures, it is able to perform efficient, runtime traffic attribution over high-volume network traces. The efficacy of Kaleido is evaluated with extensive experimental studies using the real network traces collected over three months in a large enterprise network.
Four‐Color, Enzyme‐Free Interrogation of DNA Sequences with Chemically Activated, 3′‐Fluorophore‐Labeled Nucleotides (2006)

Color reveals base: The enzymatic template-directed elongation of primers with fluorophore-labeled nucleoside triphosphates is the most frequently used reaction for determining DNA sequences. Primer extension followed by optical read out can now be achieved without enzymes. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600804_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Infrared Spectra of Aqueous Solutions. I. Metal Chelate Compounds of Amino Acids1 (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared Spectra of Aqueous Solutions. I. Metal Chelate Compounds of Amino Acids1Kazuo Nakamoto, Yukiyoshi Morimoto, and Arthur E. MartellCite this: J. Am. Chem. Soc. 1961, 83, 22, 4528–4532Publication Date (Print):November 1, 1961Publication History Published online1 May 2002Published inissue 1 November 1961https://pubs.acs.org/doi/10.1021/ja01483a009https://doi.org/10.1021/ja01483a009research-articleACS PublicationsRequest reuse permissionsArticle Views1121Altmetric-Citations248LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Staudinger Ligation (2017)

The Staudinger Ligation has been developed as a versatile bioorthogonal conjugation tool for a wide variety of biological applications both in vitro and in vivo. This chemoselective reaction allows the ligation of two (bio)molecules through an azide group and different P(III) species including phosphines, phosphites or phosphonites. It has been demonstrated to be a powerful tool for the immobilization and PEGylation of proteins, cellular labelling, the installation of natural occurring posttranslational modifications and the modification of bioorthogonal reporters in glycans, peptides, proteins or lipids, among others.
From Symbols to Sound: AI-based Investigation of Sound Synthesis (2019)

In this paper we investigate the possibility of an intelligent system for sound synthesis that would allow composition with sounds thought of in terms of abstract descriptions and operations rather than low level computer programing. Our research work is aimed at looking for plausible guidelines and strategies to map a composer’s intuitive notion of sound structure to the parametric control of electronic sound synthesis. This paper shows how we attempted to approach the problem by means of a compilation of a few well known expert systems design techniques used in Artificial Intelligence (AI) research. We begin introducing the problem from a musician’s point of view. Then we focus on two major issues of AI/Music: knowledge representation and machine learning. We propose a suitable representation scheme for sound synthesis followed by an inductive learning experiment towards an example prototype synthesiser. We also introduce the prototype functioning and suggest further work.
The possibility of dexrazoxane to prevent ovarian damage caused by toxicity (2016)

Dexrazoxane (Dexra), a catalytic topoisomerase II inhibitor and strong chelator, has been safely used in the clinic to decrease cardiotoxicity and extravasation caused by the anthracycline class of chemotherapy agents. Dexra also effectively shields the ovary from doxorubicin (DXR) chemotherapy at a dose 10-fold lower than that clinically approved for cardioprotection, ameliorating concerns that this chemoprotectant may diminish anti-tumor efficacy or increase risk for secondary malignancies. Dexra prevents acute DNA damage caused by DXR in the ovary, prolongs the reproductive lifespan of the adult female mouse post-chemotherapy, and improves offspring health. Cross-application of clinically-approved Dexra pretreatment demonstrates timely drug-based ovoprotection can be clinically implemented to improve quality of life post-cancer.
Scalable 3D Bicontinuous Fluid Networks: Polymer Heat Exchangers Toward Artificial Organs (2015)

A scalable method for fabricating architected materials well-suited for heat and mass exchange is presented. These materials exhibit unprecedented combinations of small hydraulic diameters (13.0-0.09 mm) and large hydraulic-diameter-to-thickness ratios (5.0-30,100). This process expands the range of material architectures achievable starting from photopolymer waveguide lattices or additive manufacturing.
Efficacy of Habitual Exercise for Improving Lipid Profiles Depends on the PPRA^|^gamma; Genotype in Japanese Males (2014)

Peroxisome proliferator-activated receptor gamma (PPARγ) responds to thiazolidinedione derivatives, which are ligands of PPARγ, and affects insulin resistance. Recently, a PPARγ study reported that in high-fat-diet-induced obesity, the phosphorylation of PPARγ prevented the transcription of specific PPARγ targets that have anti-obesity effects. We previously reported that genetic variants of the fatty acid desaturase were associated with plasma lipid profiles and could contribute to dyslipidemia in Japanese males. The aim of this study was to investigate the anti-obesity effects of PPARγ variants on lipid profiles. One hundred and thirty-eight (138) Japanese males participated in the study. Their serum lipid markers and the fatty acid composition of their red blood cell (RBC) membranes were determined. The stearoyl-CoA desaturase 1 (SCD1) indices were represented as the fatty acid product : precursor ratios. The participants were genotyped for the single-nucleotide polymorphism rs2938392 in the PPARγ gene. The participants' fitness habits were also surveyed by questionnaire. The effects of habitual exercise on the measured lipid parameters were compared in each genotype group. No association between the genotypes in the PPARγ gene and the biochemical data was found. However, the serum triglyceride levels and the SCD1 indices in RBC membranes were significantly higher in the participants who carried the major rs2938392 allele (A/A) and did not habitually exercise than in those who did exercise. These findings indicate that the risk for detrimental lipid profiles in the absence of habitual exercise depends on the PPARγ genotype in Japanese males.
Multihead detection for multitrack recording channels (1998)

We look at multiple-track detection for magnetic recording systems that use array heads to write and read over multiple tracks simultaneously. The recording channel is modeled as having intersymbol interference (ISI) in the axial direction, and intertrack interference (ITI) in the radial direction. Optimum multihead and single-head detectors are derived and analyzed in terms of error-probability performance for various levels of intertrack interference. Among other results, it is seen that for a range of ITI levels, codes designed to increase distance in single-head systems can provide the same coding gains for multihead systems.
Ionosphere-thermosphere global time response to geomagnetic storms (2017)

In this study, we investigate thermospheric neutral mass density heating associated with 168 CME-driven geomagnetic storms in the period of May 2001 to September 2011. We use neutral density measured by two low-Earth orbit satellites: CHAMP and GRACE. For each storm, we superpose geomagnetic and density data for the time when the IMF B$_\mathrm{z}$ component turns sharply southward chosen as the zero epoch time. This indicates the storm main phase onset. We find that the average SYM-H index reaches the minimum of $-$42 nT near 12 hours after storm main phase onset. The Joule heating is enhanced by approximately 200\% in comparison to quiet values. In respect to thermosphere density, on average, high latitude regions (auroral zones and polar caps) of both hemispheres are highly heated in the first 1.5 hour of the storm. The equatorial response is presumably associated with direct equator-ward propagation of TADs (traveling atmospheric disturbances). A slight north-south asymmetry in thermosphere heating is found and is most likely due to a positive B$_\mathrm{y}$ component in the first hours of the storm main phase.
Protective antibodies against erythrocytic stages of Plasmodium falciparum in experimental infection of the squirrel monkey, Saimiri sciureus (1982)

Serum and ascitic fluid from squirrel monkeys (Saimiri sciureus) inoculated with erythrocytic stages of Plasmodium falciparum were collected at different periods of the infection. Protection against P. falciparum was achieved by passive transfer of the sera or fluid recovered from animals after spontaneous or drug-induced cure. Purified immunoglobulins from the ascitic fluid also conferred protection. In contrast, protective antibodies directed against erythrocytic stages of P. falciparum could never be demonstrated during the acute phase of infection in spite of the high titres of malarial antibodies detected by immunofluorescence. The comparative immunochemical analysis of antigens recognized by protective and non-protective antibodies revealed quantitative differences which may be of use for the identification of antigens inducing protection.
[Role of growth factor signaling in epithelial cell plasticity during development and in carcinogenesis]. (2001)

The work described in this review addresses the multifunctional roles of growth factors and their cognate receptors in normal development and in tumorigenesis. The concept of epithelial cell plasticity is described in the context of embryonic development during which frequent remodeling occurs in epithelial tissues. The critical role of one member of the FGF family of growth factors is demonstrated in lung branching morphogenesis. Several members of this family have been shown to induce an epithelial-mesenchymal transition in a bladder carcinoma line. In vivo the same factors act in an autocrine or paracrine mode to favor tumor progression. It is suggested that an EGFR-ligand autocrine loop exerts a positive role in tumor progression of human bladder carcinoma whereas FGFR2 acts as a phenotypic tumor suppressor gene. Unexpectedly, constitutive activating mutations in FGFR3 have been uncovered in the majority of the Ta superficial tumors which progress only very rarely to the invasive stages. In contrast, in situ carcinoma, which are considered to be associated with a strong malignant potential, do not carry the FGFR3 mutations. The presence or absence of the mutations defines two distinct oncogenic pathways in bladder carcinogenesis. The studies reveal the complexities in defining the putative functions of growth factors at different times and differentiation stages during development and in tumor progression. These results emphasize the need for caution in the interpretation of studies evaluating the potential of novel anti-cancer agents and for better designs of in vitro and in vivo biological assays.
Rebuttal to commentary of Prof Yilmaz (2019)

In her commentary on winning public and political regulatory support for safe agricultural products derived from biotechnology, Prof Yilmaz invokes Aesop’s fable, posing a metaphorical pro-science ...
A General Preparation of Protected Phosphoamino Acids (2012)

Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.
Reverse Thermal Gelling PEG−PTMC Diblock Copolymer Aqueous Solution (2007)

In the search for a new thermogelling biomaterial, we are reporting poly(ethylene glycol)−poly(trimethylene carbonate) (PEG−PTMC) diblock copolymers. The PEG−PTMC (550−2750) diblock copolymer aqueous solutions (>25 wt %) underwent sol-to-gel-to-syneresis (macroscopic phase separation between the polymer and water) transition as the temperature increased. The sol-to-gel transition temperature could be controlled in a range of 20−75 °C by varying polymer concentration in water, molecular weight, and composition of the polymer. 13C NMR spectra, a transmission electron microscopic image, and dynamic light scattering suggest that the micellar aggregation through the dehydration of PEG is involved in the sol-to-gel transition. The in-situ gel formation was confirmed by subcutaneous injection of the polymer aqueous solution (30 wt %, 0.5 mL) into rats. Because of the diffusion of the polymer with a low molecular weight out of the gel, mass loss of 15 wt % was observed over 20 days in in-vivo study. On the other hand, the polymer is so stable in phosphate buffer saline that any changes in molecular weight, pH, and gel mass were not observed over the same period of time in in-vitro study.
Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function (1991)

The text in lines 6 and 7 should read: "fadA gene, is located 9 nucleotides 3' to the stop codon (TAA) of the fudB gene".The text in lines 17 and 18 should read "composed of 387 residues and has a calculated M , of 40,876.The a-and 0-subunits were separated by gel".Page 10425, Fig. 3: The nucleotide at position 112 is a cytidylate, and the guanine nucleotides a t positions 1111, 1115, and 1125 should be deleted.The protein sequence from residue 368 should read GLATMCIGLG and not GLADGCVSGLG.The DNA sequence of the fadA gene in the GenBank'" EMBL Data Bank with the accession number 505498 was already corrected.
Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005 (2003)

Lantibiotics are ribosomally synthesized oligopeptide antibiotics that contain lanthionine bridges derived by the posttranslational modification of amino acid residues. Here, we describe the cinnamycin biosynthetic gene cluster (cin) from Streptomyces cinnamoneus cinnamoneus DSM 40005, the first, to our knowledge, lantibiotic gene cluster from a high G+C bacterium to be cloned and sequenced. The cin cluster contains many genes not found in lantibiotic clusters from low G+C Gram-positive bacteria, including a Streptomyces antibiotic regulatory protein regulatory gene, and lacks others found in such clusters, such as a LanT-type transporter and a LanP-type protease. Transfer of the cin cluster to Streptomyces lividans resulted in heterologous production of cinnamycin. Furthermore, modification of the cinnamycin structural gene (cinA) led to production of two naturally occurring lantibiotics, duramycin and duramycin B, closely resembling cinnamycin, whereas attempts to make a more widely diverged derivative, duramycin C, failed to generate biologically active material. These results provide a basis for future attempts to construct extensive libraries of cinnamycin variants.
An Investigation of Micro-emulsion and Fine Foams Induced by EOR Application in Malaysian Fields (2014)

Abstract Implementation of Enhanced Oil Recovery (EOR) methods to augment additional oil recovery is gaining momentum in Malaysia. A study completed in May 2010 revealed huge potential benefit in Malaysian fields by application of various EOR schemes. It was recommended to implement Alkaline Surfactant (AS) Flooding in Terengganu A, Alkaline Surfactant Polymer (ASP) Flooding in Sabah A, Foam Assisted CO2 WAG (FACO2WAG) for Terengganu B and, Foam Assisted Natural Gas WAG (FAWAG) for Sarawak A and B. EOR offer various top side challenges in terms of formation of tight emulsion, foam and poor effluent quality discharge (EQD) water. EOR fluids breakthrough for a particular field has a lot of behaviour on type and measure of the flow assurance challenges. The studies were conducted to identify potential problems and to find out right tailored chemicals to mitigate them. This paper illustrates the method of investigation and possible resolution of the problems. It was endeavoured to find a single chemical blend to alleviate the problem to ease the logistics of operation and procurement. Background EOR Processes Enhance Oil Recovery relates to the methods to obtain additional recovery from oil reservoirs by way of flooding some fluid to generate efficient sweep towards producers. Water Alternating Gas (WAG) and Chemical Flooding also called Chemical EOR (CEOR) are commonly employed. Some methods which improve the recovery of WAG by addition of chemicals like surfactants and polymers in the water phase are termed as Enhanced WAG (EWAG). Among EWAG schemes foam assisted WAG (FAWAG) has gained acceptance where a surfactant is added in the water phase which helps generate foam as soon the gas cycle is started. Movement of this foam at the interface provide added mobility control in the WAG process. It will be pertinent to add that usual WAG process entails natural gas as the gas phase. But use of CO2 (CO2WAG) and N2 (N2WAG) have been reported 1, 2. The EOR study completed in May 2010 revealed huge potential of additional recovery in Malaysian fields by application of various EOR schemes. It was recommended to implement Alkaline Surfactant (AS) Flooding in Terengganu A, Alkaline Surfactant Polymer (ASP) Flooding in Sabah A, Foam Assisted CO2 WAG (FACO2WAG) for Terengganu B and, Foam Assisted Natural Gas WAG (FAWAG) for Sarawak A and B fields. Implementation of EOR process poses some or other challenges on top side at producers' end. Formation of tough emulsion and foams and difficulty in removal residual oil from effluent water has been well recognised by the industry. Formation of tight emulsion and fine foam during EOR production process is recognised as major flow assurance challenge which occurs due to nature of crude oil, produced water and phase separation of solids like scales, asphaltenes and naphthenates. Implementation of EOR schemes may aggravate these problems at the producers' end because of use of surfactants and polymers. Increase in pH by use of alkali in ASP Floods may also cast its shadow on the process control4, 5.
Gene B Influences Susceptibility to Chilling Injury in Cucurbita pepo (1990)

The effects of gene B on susceptibility to chilling injury (CI) in two types of summer squash (Cucurbita pepo L.) were investigated. Two pairs of near-isogenic lines with (BB) and without (B + B + ) gene B were included in the study: `Caserta' (B + B + ) and `Precocious Caserta' (BB) of the vegetable marrow type, and `Benning's Green Tint' (B + B + ) and `Benning's Yellow Tint' (BB) of the scallop type. Respiration and ethylene evolution at nonchilling temperature were consistently higher in marrows than in scallops. Gene B had no influence on respiratory rates at nonchilling temperatures; however, the presence of gene B enhanced the chilling-induced stimulation of respiration in both marrows and scallops. Temporal differences in the patterns of chilling-induced stimulation of ethylene evolution indicated a greater sensitivity to chilling in marrows than in scallops and in both types in the presence of gene B. Electrolyte leakage was decreased by storage at chilling temperature in both marrow genotypes and was not influenced by storage temperature in B + B + scallops, but was increased by storage at chilling temperature in BB scallops. Therefore, electrolyte leakage was not a good CI index for these summer squash.