gebhart/patrepeval huggingface dataset:
Reidentification of Sex Pheromones of Tea GeometridEctropis obliquaProut (Lepidoptera: Geometridae) (2015)

Tea geometrid Ectropis obliqua Prout (Lepidoptera: Geometridae) is an important defoliator of the tree crop Camellia sinensis L. in China. The sex pheromones of E. obliqua have not been identified, but have potential importance relative to the biological control of this predator. In this study, the female sex pheromones of E. obliqua were identified and evaluated for use in the monitoring and mass trapping of this pest. The sex pheromone extracts were subjected to gas chromatography-electroantennographic detection and gas chromatography-mass spectrometry. The identified chemicals were synthesized and applied to wind-tunnel tests and field experiments. (Z,Z,Z)-3,6,9-octadecatriene and 6,7-epoxy-(Z,Z)-3,9-octadecadiene were determined to be the primary sex pheromones produced by the female E. obliqua; the latter elicits the strongest electroantennogram responses from male E. obliqua antennae. However, males did not respond to single components in the wind-tunnel tests. The results of a field-trapping experiment indicated that a 4:6 v/v blend of (Z,Z,Z)-3,6,9-octadecatriene and 6,7-epoxy-(Z,Z)-3,9-octadecadiene was highly effective in attracting male moths.
Applicable Possibility Studies on a Humanoid Robot to Cooperative Work on Construction Site with a Human Worker (2004)

Applicable Possibility Studies on a Humanoid Robot to Cooperative Work on Construction Site with a Human Worker Junichiro Maeda, Hiroo Takada, Yoshio Abe Abstract: Humanoid robot walks by a pair of legs and works using two hands. About this humanoid robot, authors investigate about the possibility of its application to various works on site. Investigation is conducted by the following three methods. The first one is an investigation of matching the demand function of the latest work on the construction site with the performance which a humanoid robot holds. The second is an investigation of the way that a worker cooperates with the most advance humanoid robot. In an experiment, they transport a lightweight board from a place to a final work place and attach it together. The name of the humanoid robot used for the experiment is HRP-2, developed by the METI national project. The human worker is a fixtures carpenter. And the third is an analysis of the needs of managers of construction site on the humanoid robot. The results of the investigation show that a humanoid robot can be applied to the on-site continuation works of 24 hours, works with high stress and degree of fatigue, various impersonal works, works in which sensors are utilized, and the business in a construction site office. Keywords: Applicable possibility study, Humanoid robot, Cooperative work on site, Cooperative work with a human worker DOI: https://doi.org/10.22260/ISARC2004/0058 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley
Vertically Aligned Single-Crystal ZnO Nanotubes Grown on γ-LiAlO2(100) Substrate by Metalorganic Chemical Vapor Deposition (2007)

Vertically aligned single-crystal ZnO nanotubes were grown on a γ-LiAlO2(100) substrate by metalorganic chemical vapor deposition (MOCVD) under proper growth conditions. The diameter of these nanotubes varies from 15 to 100 nm and their wall thickness is in the range of 5–30 nm. Photoluminescence measurements indicate that these nanotubes have enhanced green emission due to a much improved surface area, which is predominant over the near-band edge emission. The synthesis of ZnO nanotubes provides a new route and a new material system for forming nanostructures such as a quantum ring.
Influence of Matrix Solution Conditions on the MALDI-MS Analysis of Peptides and Proteins (1996)

Sample-matrix preparation procedures are shown to greatly influence the quality of the matrix-assisted laser desorption/ionization (MALDI) mass spectra of peptides and proteins. In particular, dramatic mass discrimination effects are observed when the matrix 4-hydroxy-alpha-cyanocinnamic acid is used for analyzing complex mixtures of peptides and proteins. The discrimination effects are found to be strongly dependent on the sample-matrix solution composition, pH, and the rates at which the sample-matrix cocrystals are grown. These findings demonstrate the need to exercise great care in performing and interpreting the MALDI analysis of biological samples. The results also indicate that there is a reverse-phase chromatographic-like dimension in the sample-matrix preparation procedures that can be exploited to optimize the analysis. The present work describes the conditions under which the majority of components of a complex mixture of peptides and proteins can be successfully measured.
WE‐A‐BRB‐09: Dosimetric Effects of Needle Tip Localization Errors in Prostate Brachytherapy (2012)

Purpose: In prostate seed implantation, beveled tip needles are used for convenience of steering. However, needle tip localization and seed deposition errors can occur due to the bevel tip orientation. Purpose of this study is to evaluate the dosimetric consequences of needle tip localization errors due to transrectal ultrasound (TRUS) elevation beamwidth artifacts and beveled needle tip orientation in prostate seed implantation cases. Methods: Using VariSeed brachytherapy seed planning software (Varian, version 8.0), 15 clinical cases were evaluated for dosimetry (145Gy prescription, I–125 seed each of 0.375mCi). Seed positions were adjusted to represent the localization errors of 0.8mm–6.5mm (combined errors due to elevation beamwidth artifacts (2.5mm) and needle tip orientation (4mm)) for an ultrasound setting of 50% gain, and 0.9mm‐8.5mm for 100% gain. Each plan had a corresponding reference plan for comparison purposes. Plan parameters were compared using the AAPM TG‐137 guidelines for the prostate, prostatic urethra, and rectum. Results: Compared to the reference plans, due to needle tip localization errors, prostate dosimetric parameters V100, V150, and V200 deviated by −2.8%, −2.4%, and −3.6%, respectively for TRUS setting of 50% gain. D90 was decreased by 7.3Gy. Observed rectal dose increased in V100, D2cc, and D0.1cc by 0.13%, 0.96Gy, and 2.78Gy, respectively. Urethral doses D30 and D10 changed by −0.85Gy and −0.44Gy respectively. For TRUS of 100% gain, prostate V100, V150, and V200 were decreased by 2.8%, 3.0%, and 3.8%, respectively. D90 was lowered by 6.7Gy. Rectal dose increased in V100, D2cc, and D0.1cc by 0.05%, 0.37Gy and 1.44Gy, respectively. Urethral doses D30 and D10 decreased by 1.03Gy and 1.37Gy, respectively. Conclusions: Seed deposition based on the erroneous needle tip localization can cause considerable dose deviation of the prostate, rectum, and urethra. These results may be prostate volume and shape dependent. Further investigation is warranted in this regard.
New approach to current control of AC-to-DC voltage-type convertors (1994)

A new phase- and amplitude-based current control strategy for a PWM AC-to-DC voltage-type convertor is presented which introduces state feedback control of an LC filter. The feedback of the state variables of the LC filter connected to the AC side of the convertor not only compensates a DC component of the AC input current but also eliminates the oscillations of the DC output current and voltage waveforms during transients. A mathematical model of the convertor system with proposed control strategy is developed to carry out computer simulation of the system under transient operating conditions. The simulation and the experimental results of the proposed system show that the transient waveforms of AC input and DC output currents are improved greatly, even for low damping effect. The simulated results also show that the dynamic response can be significantly improved even when the DC side capacitance is substantially reduced.
Simulation and synthesis of CSP-based interprocess communication (2003)

The Sea Cucumber project synthesizes parallel software threads into hardware on FPGAs (field programmable gate arrays). A communication system is needed which can be used to communicate between parallel software threads, and which can be synthesized into hardware with matching behavior. This paper describes a satisfactory communication system and presents three main contributions. First, it proposes a concise Java API for CSP (communication sequential processes) communication. Second, it presents a general hardware solution, which establishes interfaces and protocols for a various hardware implementations. Finally, it describes a hardware implementation created for the Xilinx Virtex II FPGA for performance analysis.
Gabor Frames without Inequalities (2007)

We study the frame property of sets of time-frequency shifts (Gabor frames) on a lattice and prove that thirteen conditions are equivalent to it. Remarkably, several of these conditions can be formulated without an inequality. In particular, instead of checking the invertibility of the frame operator on the Hilbert space &lt;it&gt;L&lt;/it&gt;2(&amp;Ropf;&lt;it&gt;d&lt;/it&gt;), it suffices to verify that it is one-to-one on a certain subspace of tempered distributions.
Multiphase Flow and Thermo-Mechanical Behaviors of Solidifying Shell in Continuous Casting Mold (2013)

The metallurgical phenomena occurring in the continuous casting mold have a significant influence on the performance and the quality of steel product.The multiphase flow phenomena of molten steel,steel/slag interface and gas bubbles in the slab continuous casting mold were described by numerical simulation,and the effect of electromagnetic brake(EMBR) and argon gas blowing on the process were investigated.The relationship between wavy fluctuation height near meniscus and the level fluctuation index F,which reflects the situation of mold flux entrapment,was clarified.Moreover,based on a microsegregation model of solute elements in mushy zone with δ/γ transformation and a thermo-mechanical coupling finite element model of shell solidification,the thermal and mechanical behaviors of solidifying shell including the dynamic distribution laws of air gap and mold flux,temperature and stress of shell in slab continuous casting mold were described.
Market spiral pricing of cancer drugs (2013)

High patented cancer drug prices are not related to the high cost of development or to the relative benefit of individual drugs over available ones. Several steps could be implemented to reduce these high prices to more acceptable ones.
Cementitious artificial aggregate particles for high-skid resistance pavements (2012)

For some critical road sections, a high skid resistance of wearing course is required to minimise the risk of traffic accidents. Nowadays this skid resistance is mainly brought by the use of special aggregates as calcined bauxite, a scarce and expensive material. The paper presents a patented technology, where a special high-performance mortar is produced and crushed at early age. These cementitious artificial aggregates (CAA) can display aggregate properties close to those of calcined bauxite. Various models are presented for the prediction of the aggregate resistance to wear, fragmentation, and polishing, making possible the optimisation of CAA for specific applications.
A Multi‐Stimuli‐Responsive Molecule with Responses to Light, Oxygen, and Mechanical Stress through Flexible Tuning of Triplet Excitons (2020)

Abstract Multifunctional stimuli‐responsive materials have attracted tremendous attention because of their great potential in a variety of applications. However, conventional stimuli‐responsive emitting materials are limited to single‐stimulus response with rare attention paid to triplet excitons controlling. Herein, a multi‐stimuli‐responsive molecule (SPh‐TP) with tuning of triplet excitons is reported. During illumination, the SPh‐TP crystals with unique twisted structure and loose packing have a high probability to contact with neighboring oxygen atoms, followed by the occurrence of triplet–triplet energy transfer, and thus showing a photosensitive property. Meanwhile, the photosensitive property is also observed for the crystalline sample in vacuum, which is associated with oxygens locked in crystal pores. Upon mechanical stress, the crystalline morphology is broken and the molecules become more planar with tighter stacking, revealing its mechanochromism. In comparison to the crystalline sample, the ground sample can respond to light with different rates depending on the ratio of oxygen. This multi‐stimuli‐responsive material shows potential applications in oxygen detection and double‐encryption of information.
Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models (2019)

Psoriasis is a chronic immune-mediated skin disease that involves the interaction of immune and skin cells, and is characterized by cytokine-driven epidermal hyperplasia, deviant differentiation, inflammation, and angiogenesis. Because the available treatments for psoriasis have significant limitations, dietary products are potential natural sources of therapeutic molecules, which can repair the molecular defects associated with psoriasis and could possibly be developed for its management. Fisetin (3,7,3',4'-tetrahydroxyflavone), a phytochemical naturally found in pigmented fruits and vegetables, has demonstrated proapoptotic and antioxidant effects in several malignancies. This study utilized biochemical, cellular, pharmacological, and tissue engineering tools to characterize the effects of fisetin on normal human epidermal keratinocytes (NHEKs), peripheral blood mononuclear cells (PBMC), and CD4+ T lymphocytes in 2D and 3D psoriasis-like disease models. Fisetin treatment of NHEKs dose- and time-dependently induced differentiation and inhibited interleukin-22-induced proliferation, as well as activation of the PI3K/Akt/mTOR pathway. Fisetin treatment of TNF-α stimulated NHEKs also significantly inhibited the activation of p38 and JNK, but had enhanced effect on ERK1/2 (MAPK). In addition, fisetin treatment significantly decreased the secretion of Th1/Th-17 pro-inflammatory cytokines, particularly IFN-γ and IL-17A by 12-<i>O</i>-tetradecanolylphorbol 13-acetate (TPA)-stimulated NHEKs and anti-CD3/CD28-activated human PBMCs. Furthermore, we established the in vivo relevance of fisetin functions, using a 3D full-thickness human skin model of psoriasis (FTRHSP) that closely mimics in vivo human psoriatic skin lesions. Herein, fisetin significantly ameliorated psoriasis-like disease features, and decreased the production of IL-17 by CD4+ T lymphocytes co-cultured with FTRHSP. Collectively, our data identify the prodifferentiative, antiproliferative, and anti-inflammatory effects of fisetin, via modulation of the PI3K-Akt-mTOR and p38/JNK pathways and the production of cytokines in 2D and 3D human skin models of psoriasis. These results suggest that fisetin has a great potential to be developed as an effective and inexpensive agent for the treatment of psoriasis and other related inflammatory skin disorders.
Protection or susceptibility to devastating childhood epilepsy: Nodding Syndrome associates with immunogenetic fingerprints in the HLA binding groove (2020)

Nodding syndrome (NS) is a devastating and enigmatic childhood epilepsy. NS is accompanied by multiple neurological impairments and neuroinflammation, and associated with the parasite Onchocerca volvulus (Ov) and other environmental factors. Moreover, NS seems to be an 'Autoimmune Epilepsy' since: 1. ~50% of NS patients have neurotoxic cross-reactive Ov/Leimodin-I autoimmune antibodies. 2. Our recently published findings: Most (~86%) of NS patients have glutamate-receptor AMPA-GluR3B peptide autoimmune antibodies that bind, induce Reactive Oxygen Species, and kill both neural cells and T cells. Furthermore, NS patient's IgG induce seizures, brain multiple damage alike occurring in brains of NS patients, and elevation of T cells and activated microglia and astrocytes, in brains of normal mice. Human Leukocyte antigen (HLA) class I and II molecules are critical for initiating effective beneficial immunity against foreign microorganisms and contributing to proper brain function, but also predispose to detrimental autoimmunity against self-peptides. We analyzed seven HLA loci, either by next-generation-sequencing or Sequence-Specific-Oligonucleotide-Probe, in 48 NS patients and 51 healthy controls from South Sudan. We discovered that NS associates significantly with both protective HLA haplotype: HLA-B*42:01, C*17:01, DRB1*03:02, DQB1*04:02 and DQA1*04:01, and susceptible motif: Ala24, Glu63 and Phe67, in the HLA-B peptide-binding groove. These amino acids create a hydrophobic and sterically closed peptide-binding HLA pocket, favoring proline residue. Our findings suggest that immunogenetic fingerprints in HLA peptide-binding grooves tentatively associate with protection or susceptibility to NS. Accordingly, different HLA molecules may explain why under similar environmental factors, only some children, within the same families, tribes and districts, develop NS, while others do not.
Conceptual Modeling of Business Networks and Business Strategies (2003)

The sophistication of technical and organizational networking enables not only a broader range of business networks and business strategies, but also allows for their faster adaptation to innovations.By increasing the degree of formalization of strategy modeling, model consistency can be enhanced and specifications can be reused in subsequent business engineering phases like process (re-)design and information systems development.Modeling techniques for business network specification and business strategy specification are outlined and notations are presented.Experience from applying these techniques in financial service companies is summarized.
Domain nucleation and relaxation kinetics in ferroelectric thin films (2000)

The time-dependent relaxation of the remanent polarization in epitaxial lead zirconate titanate (PbZr0.2Ti0.8O3) ferroelectric thin films, containing a uniform two-dimensional grid of 90° domains (c axis in the plane of the film), is examined using piezoresponse microscopy. The 90° domain walls preferentially nucleate the 180° reverse domains during relaxation, with a significant directional anisotropy. Relaxation occurs through the nucleation and growth of reverse domains, which subsequently coalesce and consume the entire region as a function of time.
Formation of Bioerodible Polymeric Microspheres and Microparticles by Rapid Expansion of Supercritical Solutions (1991)

Polyhydroxy acids [poly(L-lactic acid) (L-PLA), poly(D,L-lactic acid) (DL-PLA), and poly-(glycolic acid) (PGA)], biocompatible and bioerodible polymers that are being investigated for controlled delivery of pharmaceuticals and are approved by the Food and Drug Administration for in vivo sutures and bone repair implants, have been dissolved in supercritical CO2 and precipitated by rapid expansion of the resulting supercritical solutions (RESS). The formation of these microparticles and microspheres is a first step toward the goal of producing, in a single processing step, drug-loaded polymeric microspheres for use in controlled release applications. Nucleation of poly(L-lactic acid) from CO2 and CO2-acetone mixtures produced microparticles and microspheres ranging from 4 to 25 microns. Microspheres (2-20 microns) were also obtained with chlorotrifluoromethane as solvent. Commercial L-PLA precipitated after extraction of low molecular weight oligomers showed degradation kinetics similar to that of the starting material. The precipitation of DL-PLA from CO2 produced irregular-sized particles (10-20 microns). PGA, a polymer insoluble in most organic solvents, was found to be soluble in supercritical CO2. Nucleation of PGA from CO2 produced both regular-sized particles and needles of 10-40-microns length. The total solubility of commercial L-PLA in supercritical CO2 at 250 bar and 55 degrees C decreased from 0.14 wt % to less than 0.05 wt % and then leveled off as the cumulative flow of CO2 per unit mass of L-PLA loaded in the extractor increased beyond 20 standard L of CO2/g of L-PLA. Use of acetone (1 wt %) as a cosolvent increased L-PLA solubility by approximately 500%.
Tetracycline-Inducible Viral Interleukin-10 Intraocular Gene Transfer, Using Adeno-Associated Virus in Experimental Autoimmune Uveoretinitis (2005)

Members of the adeno-associated virus (AAV) family are good candidates for the treatment of ocular diseases because of their relative lack of pathogenicity. We studied the effect of intraocular injection of AAV2-viral IL-10 (vIL-10) on retinal S-antigen-induced experimental autoimmune uveoretinitis (EAU) in Lewis rats. We demonstrated that AAV2/2-GFP injected into the vitreous body transduced the iris and ciliary body, or anterior uvea, and the retina. We showed that intravitreal injection of the AAV2/2-tetON-vIL-10 construct achieved detectable levels of vIL-10 mRNA and protein within the eye and was effective in protecting the rat retina against destruction. This protection was dependent on the level of vIL-10 present in the aqueous humor/ vitreous body. Intravitreal injection of the same construct encased within an AAV5 shell, AAV2/5-tetONvIL- 10, did not confer any degree of protection. It appeared that the AAV2/5 vectors did not transduce the anterior uvea, the site at which inflammatory cells first localize in EAU, nor the ganglion cell layer; induced low expression of vIL-10 mRNA; and did not achieve detectable levels of transgene expression in the aqueous humor/vitreous body. Local treatment with AAV2/2-tetON-vIL-10 did not dampen the systemic immune response, as determined by S-antigen-specific lymphocyte proliferation. Our results show that local intravitreal injection of AAV2/2 is an effective means by which to deliver immunoregulatory molecules into the eye during uveitis, a chronic human ocular disease.
Haemostasis and cancer. (1989)

Patients with cancer have an increased incidence of thromboembolic disease and haemostatic abnormalities, and there is considerable evidence that the haemostatic system is involved in the growth and spread of malignant disease. Anti-haemostatic agents have given promising results in the treatment of experimental tumours, and several clinical trials in humans have been initiated. The formation of fibrin around the tumour may be a particularly important factor in malignant dissemination. The precise mechanisms of peri-tumour fibrin deposition remain to be elucidated, but may involve alterations in local vascular permeability and the presence of tumour and/or macrophage procoagulants. In addition to their role in fibrin formation, haemostatic components may also be involved in neovascularisation and angiogenesis.
Development of augmented reality technology for surgical resection accuracy via improved visualization (2023)

A challenge in arthroscopic hip surgery is visualizing patient anatomy beneath the skin's surface, specifically in femoroacetabular impingement (FAI) surgeries. FAI is characterized by a bony deformity and hip pain that leads to osteoarthritis. Due to both poor visualization and under-resection of the bone deformity in FAI surgeries, patients often undergo revision surgeries and/or ongoing pain. During surgery, the patient's preoperative medical images are displayed on a monitor alongside the arthroscope's view. Rather than the surgeon mentally fusing the medical images of the hip anatomy onto the patient, augmented reality (AR) could integrate surgical visualization through a head-mounted display that overlays the patient's virtual anatomy onto the real world. This work presents the results from a preliminary user study, which assessed the functionality and accuracy of our AR live-resection tracking model via Microsoft Hololens 2 with a motion capture (MoCap) system. Our primary objective was to assess the initial accuracy of our live-resection tracking model in a simplified simulation with a physical object compared to our ability to track the resection in a virtual object. Our secondary objective was to obtain user feedback on the current AR system for resection tracking.