gebhart/patrepeval huggingface dataset:
Nuclear methods in air and water pollution analysis (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNuclear methods in air and water pollution analysisFrank A. IddingsCite this: Environ. Sci. Technol. 1969, 3, 2, 132–140Publication Date (Print):February 1, 1969Publication History Published online1 May 2002Published inissue 1 February 1969https://pubs.acs.org/doi/10.1021/es60025a006https://doi.org/10.1021/es60025a006research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isopropyl Alcohol Intoxication-Reply (1991)

In Reply. —We agree with Dr Wrenn that identification of the specific offending alcohol is important in managing patients with acute intoxications. One purpose of our report was to alert readers to the laboratory findings in patients with acute isopropyl alcohol intoxication, a disorder that we believe is common, yet little appreciated. Unfortunately, many breathalyzer tests as well as a newly introduced saliva alcohol dipstick method 1 do not distinguish between alcohols. We agree with his comments about management of the acute intoxications, including generous administration of thiamine in these patients, many of whom also abuse ethanol and eat sparingly and poorly. Among the intoxicant alcohols (ethanol, methanol, isopropyl alcohol, ethylene glycol) isopropyl alcohol and ethanol are the only ones that are repeatedly and deliberately ingested for prolonged periods. The chronic effects of isopropyl alcohol are thus important. We are pleased to know that Wrenn's neurological experience in emergency medicine
Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic rapid eye movement sleep behavior disorder (2017)

DAT-SPECT identifies IRBD patients at short-term risk for synucleinopathy. Decreased FP-CIT putamen uptake greater than 25% predicts synucleinopathy after 3 years' follow-up. These observations may be useful to select candidates for disease modification trials in IRBD. Ann Neurol 2017;82:419-428.
A Small Yeast RNA Blocks Hepatitis C Virus Internal Ribosome Entry Site (HCV IRES)-Mediated Translation and Inhibits Replication of a Chimeric Poliovirus under Translational Control of the HCV IRES Element (1998)

Hepatitis C virus (HCV) infection frequently leads to chronic hepatitis and cirrhosis of the liver and has been linked to development of hepatocellular carcinoma. We previously identified a small yeast RNA (IRNA) capable of specifically inhibiting poliovirus (PV) internal ribosome entry site (IRES)-mediated translation. Here we report that IRNA specifically inhibits HCV IRES-mediated translation both in vivo and in vitro. A number of human hepatoma (Huh-7) cell lines expressing IRNA were prepared and characterized. Constitutive expression of IRNA was not detrimental to cell growth. HCV IRES-mediated cap-independent translation was markedly inhibited in cells constitutively expressing IRNA compared to control hepatoma cells. However, cap-dependent translation was not significantly affected in these cell lines. Additionally, Huh-7 cells constitutively expressing IRNA became refractory to infection by a PV-HCV chimera in which the PV IRES is replaced by the HCV IRES. In contrast, replication of a PV-encephalomyocarditis virus (EMCV) chimera containing the EMCV IRES element was not affected significantly in the IRNA-producing cell line. Finally, the binding of the La autoantigen to the HCV IRES element was specifically and efficiently competed by IRNA. These results provide a basis for development of novel drugs effective against HCV infection.
Exploration of a digital-based solution for the generation of 2.4GHz OQPSK test stimuli (2021)

In this paper, we explore a digital-based solution for the generation of 2.4GHz OSQSK test stimuli. The objective is to reduce the testing costs of ZigBee receivers by enabling their test on a standard digital Automatic Test Equipment (ATE). The proposed strategy relies on the generation of a modulated square wave signal in the intermediate frequency band using a digital tester channel, and the filtering of one of its harmonics to produce the RF signal. Appropriate modulation format has to be encoded in the square-wave signal so that the typical characteristics of a ZigBee signal are present in the chosen harmonic component. A dedicated pre-processing algorithm has been developed to determine this encoding. The proposed strategy is then evaluated through Matlab simulations, taking into account the practical constraints imposed by a standard digital ATE.
Design of electrical conductive poly(lactic acid)/carbon black composites by induced particle aggregation (2020)

Abstract The electrical conductivity of ternary composites composed of a biopolymer blend with conductive particles (carbon black [CB]) is induced by the control of particle dispersion in the dispersed phase. If the CB particles have higher chemical affinity for the secondary phase (poly(caprolactone) [PCL]]) than the matrix (poly(lactic acid) [PLA]), especially as the concentration of the PCL phase decreases significantly to 4 wt%, the PCL phase induces the aggregation of CB particles beyond the selective localization, resulting in a shift of the particle percolation threshold to a lower concentration of particles (2.44 wt% CB). Moreover, the mixing ratio between the CB and the PCL phase significantly affects the formation of percolation of particles. When the mixing ratio of CB to PCL is equivalent (1:1), the ternary composite shows high electrical DC conductivity above 1 S/m with 10 wt% CB. The addition of a small amount of PCL induces the formation of particle aggregates with a high aspect ratio, providing more electron transfer pathways due to the multiple points of contact between the particle aggregates (power law scaling exponent of the composites ~2.14). Meanwhile, a binary composite (PLA/CB) never reaches high electrical conductivity of 1 S/m and even requires a greater concentration of CB (13 wt% CB for 10 −3 S/m) to accomplish electron transfer because of the small aspect ratio of randomly dispersed particle aggregates (power law scaling exponent ~3.20).
Enhanced Stability of Gold Colloids Produced by Femtosecond Laser Synthesis in Aqueous Solution of CTAB (2009)

Femtosecond laser ablation of gold in an aqueous solution of cetyl trimethylammonium bromide (CTAB) is shown to produce nanoparticle suspensions with superior colloidal stability compared to other surfactants, with shelf lives exceeding 2 months even at low concentrations of CTAB, below 1 mM. CTAB also helps control nanoparticle size with mean diameters of 6.3, 5.6, and 4.7 nm obtained in 0.1, 0.5, and 1 mM concentrations of CTAB respectively, compared to 11.9 nm obtained in pure deionized water under same ablation conditions. The size distributions produced with low concentrations of CTAB are comparable to those produced by other surfactants, typically used at high concentrations.
A Versatile Oblique Plane Microscope for Large-Scale and High-Resolution Imaging of Subcellular Dynamics - Public Data (2020)

We present an Oblique Plane Microscope that uses a bespoke glass-tipped tertiary objective to improve the resolution, field of view, and usability over previous variants. Owing to its high numerical aperture optics, this microscope achieves lateral and axial resolutions that are comparable to the square illumination mode of Lattice Light-Sheet Microscopy, but in a user friendly and versatile format. Given this performance, we demonstrate high-resolution imaging of clathrin-mediated endocytosis, vimentin, the endoplasmic reticulum, membrane dynamics, and Natural Killer-mediated cytotoxicity. Furthermore, we image biological phenomena that would be otherwise challenging or impossible to perform in a traditional light-sheet microscope geometry, including cell migration through confined spaces within a microfluidic device, subcellular photoactivation of Rac1, diffusion of cytoplasmic rheological tracers at a volumetric rate of 14 Hz, and large field of view imaging of neurons, developing embryos, and centimeter-scale tissue sections.
ChemInform Abstract: THALLIUM IN DER ORGANISCHEN SYNTH. 34. MITT. OXIDATION VON ACETYLENEN MIT THALLIUM(III)‐NITRAT (1973)

Abstract Bei der Oxidation mit Tl(III)‐nitrat in wasserhaltigem Glyme in Gegenwart v HClO 4 werden die Acetylene (I) in die Diketone (II), die Acetylene (III) in Acyloine (IV) (die mit den entsprechenden Diketonen verunreinigt und sehr schwer rein isolierbar sind), die Acetylene (V) in die Carbonsäuren (VI) und Alkylarylacetylene in komplexe Ketongemische übergeführt.
Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates (1980)

Benzyloxycarbonyl-phenylalanyl-arginine 4-methyl-7-coumarylamide was found to be an excellent substrate for the fluorimetric assay of cathepsin B, and arginine 4-methyl-7-coumarylamide for cathepsin H. Procedures were developed that are very convenient, and avoid the hazards associated with the use of naphthylamides.
Cervical cytology in menopausal women at high risk for endometrial disease. (1998)

The objective of this study was to evaluate the value of cervical cytology in the diagnosis of endometrial disease in women after menopause. In 128 consecutive menopausal women presenting with uterine bleeding (116) or in whom endometrial cells were found on a previous cervical cytology smear (12), an endo- and ectocervical smear was taken before hysteroscopy with curettage. The results of the cervical cytology were compared with the endometrial histology. Mean age was 59 years. The average duration of menopause was 10 years. Endometrial carcinoma was diagnosed by endometrial sampling in six women. In two of these cases cervical smears did not contain endometrial cells. The presence of endometrial cells on ectocervical cytology showed a sensitivity of 67% and a specificity of 78% for endometrial carcinoma vs 80% and 76%, respectively, for endocervical cytology. The positive predictive value for endometrial malignancy of the presence of endometrial cells on cervical cytology ranged between 17% and 13%. The presence of 'atypical' endometrial cells on cervical smear was associated with endometrial malignancy in almost half the cases. Cervical cytology is of limited value in the diagnosis and the management of postmenopausal endometrial disease.
Effect of Citronella Oil on Time Kill Profile, Leakage and Morphological Changes ofPropionibacterium acnes (2010)

Abstract The aim of this study was to investigate the effect of citronella oil (Java type) (Cymbopogon winterianus Jowitt) on Propionibacterium acnes DMST 14916. Citronella oil compositions were determined by gas chromatography mass spectrometry (GC/MS). Anti-P. acnes activity of citronella oil and its major components were also investigated. After exposure with P. acnes at various concentrations of citronella oil (0–100 μL/mL), time-kill profiles, pentose leakage and electron microscopic characteristics were determined. The GC/MS results revealed that the major constituents of the oil were citronellal, geraniol and citronellol. At all concentrations above Minimum Bactericidal Concentrations (MBCs; 0.625μL/mL), this essential oil killed P. acnes in a dose-dependent manner. The intracellular materials leakage and electron microscopic characteristics evidenced that the major target sites of antibacterial activity appeared to be cell wall, cytoplasmic membrane and intracellular materials. Citronella oil exerted satisfactory bacteriostatic and bactericidal actions against P. acnes.
A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF (2009)

ADAMTS13 metalloprotease regulates the multimeric size of von Willebrand factor (VWF) by cleaving the Tyr1605-Met1606 bond in the VWF A2 domain. The mechanisms of VWF recognition by ADAMTS13 have yet to be fully resolved. Most studies have focused on the role of exosites within the VWF A2 domain, involved in interaction with the ADAMTS13 spacer domain. In the present study, we expressed different C-terminal domain VWF fragments and evaluated their binding to ADAMTS13 and its truncated mutants, MDTCS and del(TSP5-CUB). Using plate binding assay and surface plasmon resonance, we identified a novel ADAMTS13 binding site (K(D) approximately 86 nM) in the region of VWF spanning residues 1874 to 2813, which includes the VWF D4 domain and that interacts with the C-terminal domains of ADAMTS13. We show that the interaction occurs even when VWF is in static conditions, assumed to be globular and where the VWF A2 domain is hidden. We demonstrate that C-terminal VWF fragments, as well as an antibody specifically directed toward the VWF D4 domain, inhibit VWF proteolysis by ADAMTS13 under shear conditions. We propose that this novel VWF C-terminal binding site may participate as the initial step of a multistep interaction ultimately leading to proteolysis of VWF by ADAMTS13.
Vaccination and world health (1995)

Partial table of contents: PLENARY SESSION ADDRESSES. Vaccination: Successes and Challenges (R. Henderson). Strategies for Disease Control/Eradication in the Americas (C. de Quadros). Vaccine Production and Supply in Developing Countries (S. Shin & G. Shahi). The Development of New Vaccines (G. Ada). Evaluation of New Vaccines: Challenges for HIV/AIDS (S. Vermund, et al.). Does Economic Analysis Affect Vaccination Policy? (C. Waddington & H. Goodman). The Contribution of Modelling to Vaccination Policy (P. Fine). Who Determines National Health Policies? (S. Murugasampillay). WORKSHOP REPORTS. Evaluating New Vaccines (F. Nkrumah & A. Hall). When to Release New Vaccines (N. Gu?rin & P. Smith). Vaccine Production and Supply in Developing Countries (S. Shin & C. Lanata). Optimizing Use of Resources for Long-Term Development (A. LaFond & A. Mills). CLOSING SESSION ADDRESSES. Future Directions (A. Lucas). Index.
Neonatal Herpes Simplex Infection and the Three Musketeers (2011)

Metaphorically, the Three Musketeers can represent our defenses against viral pathogens. Actually, there were four Musketeers; the hero D'Artagnan was an add-on. In Dumas's novel, the Musketeers' motto, “one for all and all for one,” indicated a synergistic approach. Our four antiviral defenses include specific and nonspecific antiviral therapy, passive immunization, and, finally, active immunization, represented by D'Artagnan. We do not have all these defenses for every pathogen. Although active and passive immunization and nonspecific treatment (vitamin A)1 are available for measles, it would be better if a specific therapy existed, particularly now, when some parents are not vaccinating their . . .
Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion (2022)

NK cell exhaustion is caused by chronic exposure to activating stimuli during viral infection, tumorigenesis, and prolonged cytokine treatment. Evidence suggests that exhaustion may play a role in disease progression. However, relative to T cell exhaustion, the mechanisms underlying NK cell exhaustion and methods of reversing it are poorly understood. Here, we describe a potentially novel in vitro model of exhaustion that uses plate-bound agonists of the NK cell activating receptors NKp46 and NKG2D to induce canonical exhaustion phenotypes. In this model, prolonged activation resulted in downregulation of activating receptors, upregulation of checkpoint markers, decreased cytokine production and cytotoxicity in vitro, weakened glycolytic capacity, and decreased persistence, function, and tumor control in vivo. Furthermore, we discovered a beneficial effect of NK cell inhibitory receptor signaling during exhaustion. By simultaneously engaging the inhibitory receptor NKG2A during activation in our model, cytokine production and cytotoxicity defects were mitigated, suggesting that balancing positive and negative signals integrated by effector NK cells can be beneficial for antitumor immunity. Together, these data uncover some of the mechanisms underlying NK cell exhaustion in humans and establish our in vitro model as a valuable tool for studying the processes regulating exhaustion.
Yesterday, Today, and Tomorrow: 50 Years of Software Engineering (2018)

In 2018, we’re now 50 years after the famous groundbreaking conference on software engineering in Garmisch, organized by its chairman F.L. Bauer and his cochairs L. Bolliet and H.J. Helms. This conference introduced the notion and discipline of software engineering. This is a moment to look back at what we’ve achieved, what we haven’t achieved, where we are today, and what challenges lie ahead. This article is part of a theme issue on software engineering’s 50th anniversary.
Immune Implications of Gene Therapy for Hemophilia (2004)

Similar to any novel treatment strategy for hemophilia, gene therapy faces the question of the risk of formation of inhibitory antibodies to the therapeutic factor VIII or factor IX protein. Activation of CD4 (+) or CD8 (+) T cells could lead to antibody formation or cytotoxic T lymphocyte responses to transgene-expressing cells. Preclinical studies in animal models of hemophilia A and B with different mutations in the dysfunctional gene shed light on the risk for such immune responses and point toward strategies to avoid immune activation or even promote tolerance induction. The impacts of variables such as choice and design of gene transfer vector, underlying gene mutation, route of vector administration, and transient immune suppression are discussed. Maintenance of immunological hyporesponsiveness to the therapeutic gene product is critical for successful gene therapy. Recent studies provide evidence for tolerance induction to coagulation factor antigens by viral hepatic or neonatal in vivo gene transfer, by in utero gene delivery, and by oral or nasal administration of protein or peptides.
1,2-Addition of Activated Vinyl Carbanions to α,β-Unsaturated Carbonyls (1989)

Abstract Methyl acrylate reacts with α,β-unsaturated aldehydes in the presence of a tertiary amine to afford 1,2-addition products.
Electrode Locations and Artifact Suppression. (2016)

&lt;p&gt;(A) Surface model of an atlas brain showing locations of electrodes over the parietal regions in each of the three patients. Signals measured from only these electrodes were used in the analysis. Refer to &lt;a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002424#pbio.1002424.s002" target="_blank"&gt;S2 Fig&lt;/a&gt; for the stimulation electrodes and electrodes over other regions. (B) Schematic of stimulation waveform used. Stimulation consisted of one biphasic pulse 400 μs in duration every 100 ms for 5 s. (C) Stimulation artifacts in representative sample traces from four electrodes (top). Enlarged portion denoted by the black line (bottom). Artifacts appear as periodic sharp deflections with stereotyped waveforms. (D) Traces from the same four electrodes as in (B) after the artifact suppression procedure. The artifacts are suppressed compared to the signal amplitude. (E) Spectrum of the fourth waveform in (B) showing peaks at 10 Hz and harmonics of 10 Hz corresponding to artifact waveform. Top: Full frequency range. Bottom: Zoom-in on low frequencies. (F) Spectra of the same waveform after artifact suppression confirming the effectiveness of the algorithm. The only remaining exogenous peak is at 60 Hz, caused by electric line noise.&lt;/p&gt;
Demo: Zero touch configuration (2013)

The deployment of devices at remote or distributed locations is a typical scenario e.g. in large enterprise networks or industrial applications. In the deployment of a device identification of the device and the establishment of security relations (trust) between the device and other elements of the infrastructure is crucial. Usually, the process requires either to pre-configure the device or to let administrators physically access the device for configuration. Both options induce costs. For functional configurations and software distribution zero configuration solutions are available. One important step hereby is the establishment of trust into the individual device by the device owner. This trust establishment requires in typical schemes a large organizational involvement of the device owner resp. operator. The approach presented in this demo addresses the step of initial trust establishment. The demonstration shows the process of a device being securely configured and provides a visualization through a meta-data graph generated from an IFMAP server.
Dysbindin-1 Involvement in the Etiology of Schizophrenia (2017)

Schizophrenia is a major psychiatric disorder that afflicts about 1% of the world's population, falling into the top 10 medical disorders causing disability. Existing therapeutic strategies have had limited success on cognitive impairment and long-term disability and are burdened by side effects. Although new antipsychotic medications have been launched in the past decades, there has been a general lack of significant innovation. This lack of significant progress in the pharmacotherapy of schizophrenia is a reflection of the complexity and heterogeneity of the disease. To date, many susceptibility genes have been identified to be associated with schizophrenia. <i>DTNBP1</i> gene, which encodes dysbindin-1, has been linked to schizophrenia in multiple populations. Studies on genetic variations show that <i>DTNBP1</i> modulate prefrontal brain functions and psychiatric phenotypes. Dysbindin-1 is enriched in the dorsolateral prefrontal cortex and hippocampus, while postmortem brain studies of individuals with schizophrenia show decreased levels of dysbindin-1 mRNA and protein in these brain regions. These studies proposed a strong connection between dysbindin-1 function and the pathogenesis of disease. Dysbindin-1 protein was localized at both pre- and post-synaptic sites, where it regulates neurotransmitter release and receptors signaling. Moreover, dysbindin-1 has also been found to be involved in neuronal development. Reduced expression levels of dysbindin-1 mRNA and protein appear to be common in dysfunctional brain areas of schizophrenic patients. The present review addresses our current knowledge of dysbindin-1 with emphasis on its potential role in the schizophrenia pathology. We propose that dysbindin-1 and its signaling pathways may constitute potential therapeutic targets in the therapy of schizophrenia.
ChemInform Abstract: CONFORMATIONALLY RESTRAINED FENTANYL ANALOGS. 2. SYNTHESIS AND ANALGETIC EVALUATION OF PERHYDRO‐1,6‐NAPHTHYRIDIN‐2‐ONES (1985)

Abstract Conformationally Restrained Fentanyl Analogues.