gebhart/patrepeval huggingface dataset:
Generation and Characterization of Pluripotent Stem Cells from Cloned Bovine Embryos1 (2005)

Bovine embryonic stem (ES) cell lines reported to date vary in morphology and marker expression (e.g., alkaline phosphatase [ALPL], stage-specific embryonic antigen 4 [SSEA4], and OCT4) that normally are associated with the undifferentiated, pluripotent state. These observations suggest that the proper experimental conditions for consistently producing bovine ES cells have not been identified. Here, we report three bovine ES cell lines, one from in vitro-fertilized and two from nuclear transfer embryos. These bovine ES cells grew in large, multicellular colonies resembling the mouse ES and embryonic germ (EG) cells and human EG cells. Throughout the culture period, most of the cells within the colonies stained positive for ALPL and the cell surface markers SSEA4 and OCT4. The staining patterns of nuclear transfer ES cells were identical to those of the blastocysts generated in vitro yet different from most previously reported bovine ES cell lines, which were either negative or not detected. After undifferentiated culture for more than 1 yr, these cells maintained the ability to differentiate into embryoid bodies and derivatives of all three EG layers, thus demonstrating their pluripotency. However, unlike the mouse and human ES cells, following treatment with trypsin, type IV collagenase, or protease E, our bovine ES cells failed to self-renew and became spontaneously differentiated. Presumably, this resulted from an interruption of the self-renewal pathway. In summary, we generated pluripotent bovine ES cells with morphology similar to those of established ES cells in humans and mice as well as marker-staining patterns identical to those of the bovine blastocysts.
Role of Smoke Stimulatory and Inhibitory Biomolecules in Phytochrome-Regulated Seed Germination of Lactuca sativa (2019)

The biologically active molecules karrikinolide (KAR<sub>1</sub>) and trimethylbutenolide (TMB) present in wildfire smoke play a key role in regulating seed germination of many plant species. To elucidate the physiological mechanism by which smoke-water (SW), KAR<sub>1</sub>, and TMB regulate seed germination in photosensitive 'Grand Rapids' lettuce (<i>Lactuca sativa</i>), we investigated levels of the dormancy-inducing hormone abscisic acid (ABA), three auxin catabolites, and cytokinins (26 isoprenoid and four aromatic) in response to these compounds. Activity of the hydrolytic enzymes α-amylase and lipase along with stored food reserves (lipids, carbohydrate, starch, and protein) were also assessed. The smoke compounds precisely regulated ABA and hydrolytic enzymes under all light conditions. ABA levels under red (R) light were not significantly different in seeds treated with TMB or water. However, TMB-treated seeds showed significantly inhibited germination (33%) compared with water controls (100%). KAR<sub>1</sub> significantly enhanced total isoprenoid cytokinins under dark conditions in comparison with other treatments; however, there was no significant effect under R light. Enhanced levels of indole-3-aspartic acid (an indicator of high indole-3-acetic acid accumulation, which inhibits lettuce seed germination) and absence of trans-zeatin and trans-zeatin riboside (the most active cytokinins) in TMB-treated seeds might be responsible for reduced germination under R light. Our results demonstrate that SW and KAR<sub>1</sub> significantly promote lettuce seed germination by reducing levels of ABA and enhancing the activity of hydrolytic enzymes, which aids in mobilizing stored reserves. However, TMB inhibits germination by enhancing ABA levels and reducing the activity of hydrolytic enzymes.
Antiplasmodial Alkaloids from the Stem Bark ofStrychnos malacoclados (2011)

From the stem bark of Strychnos malacoclados, one new bisindole alkaloid, 3-hydroxylongicaudatine Y (1), was isolated along with the known alkaloids vomicine (2), bisnordihydrotoxiferine (3), divarine (4), longicaudatine (5), longicaudatine Y (6), and longicaudatine F (7). All the compounds were tested for their antimalarial activity against the chloroquine-sensitive 3D7 and -resistant W2 strains of Plasmodium falciparum. Longicaudatine was the most active compound with IC₅₀ values of 0.682 and 0.573 µM, respectively. The activity of compounds 1, 3, 4, 6, and 7 against the two strains ranged from 1.191 to 6.220 µM and 0.573 to 21.848 µM, respectively. Vomicine (2), the only monomer isolated, was inactive. The alkaloids of the longicaudatine-type ( 1, 5-7) were more active than those of the caracurine-type (3- 4). The presence of the ether bridge in the molecule seems to increase the antiplasmodial activity. Compounds 1, 5, and 7 were tested against the WI-38 human fibroblast cell line. Longicaudatine was the most cytotoxic compound with an IC₅₀ of 2.721 µM. Longicaudatine F was 40-46 times more active against the two strains of P. falciparum than against the human fibroblasts and was thus considered as the more selective alkaloid. The structures of the compounds were determined based on the analysis of their spectral data.
Work time, work interference with family, and psychological distress. (2002)

Despite public concern about time pressures experienced by working parents, few scholars have explicitly examined the effects of work time on work-family conflict. The authors developed and tested a model of the predictors of work time and the relationships between time, work interference with family (WIF). and psychological distress. Survey data came from 513 employees in a Fortune 500 company. As predicted, several work and family characteristics were significantly related to work time. In addition, work time was significantly, positively related to WIF, which in turn was significantly, negatively related to distress. The results suggest that work time fully or partially mediates the effects of many work and family characteristics on WIF.
Production of Pollen-Sized "Microforaminifera" from "Normal" Foraminifera (1968)

Pollen-sized 9microforaminifera9 were produced from 9normal-sized9 calcareous foraminifera of the species Ammonia limnetes (Todd and Bronnimann) by the differential destruction of the test with 5 percent HC1.
Hepatitis B virus: pathogenesis and prevention of primary cancer of the liver. (1982)

The currently available data indicate that persistent infection of the liver with hepatitis B virus (HBV) is involved in the etiology and pathogenesis of nearly all primary hepatocellular carcinomas in humans. Immunization of high risk populations with the hepatitis B vaccine and prevention of mother-to-child transmission of HBV with hepatitis B immunoglobulin should prevent the development of chronic hepatitis B infection and, therefore, should also prevent the development of hepatocellular carcinoma. How HBV "causes" cancer of the liver is unknown. Research on the role of HBV in hepatocarcinogenesis may provide information on how HBV and other viruses induce cancer and may lead to the discovery of other virus-cancer relationships in humans.
Increased osteoblast functions among nanophase titania/poly(lactide‐co‐glycolide) composites of the highest nanometer surface roughness (2006)

Currently, the scientific challenges for bone tissue engineering lie in the development of suitable scaffold materials that can improve bone cell adhesion, proliferation, and differentiation. The design of nanophase titania/poly(lactide-co-glycolide) (PLGA) composites offers an exciting approach to combine the advantages of a degradable polymer with nanosize ceramic particles to optimize the physical and biological properties necessary for bone regeneration. Moreover, because of the presence of nanosized ceramics, such composites can be formulated to match the surface roughness of bone. For these reasons, the objective of the present in vitro study was to investigate osteoblast (bone-forming cell) adhesion and long-term functions on nanophase titania/PLGA composites that mimic the surface roughness of bone. Various sonication powers were applied in this study to manipulate titania dispersions in PLGA and consequently control their surface roughness. Most importantly, results correlated better osteoblast adhesion and long-term functions (such as collagen, alkaline phosphatase activity, and calcium-containing mineral deposition) among nanophase titania/PLGA composites that had surface roughness values closer to natural bone. In this manner, this present study demonstrated that the nanophase titania/PLGA composites sonicated to have nanometer surface roughness values can improve osteoblast functions necessary for enhanced bone tissue engineering applications.
Optical conductivity of manganites: Crossover from Jahn-Teller small polaron to coherent transport in the ferromagnetic state (1998)

We report on the optical properties of the hole-doped manganites ${\mathrm{Nd}}_{0.7}{\mathrm{Sr}}_{0.3}{\mathrm{MnO}}_{3},$ ${\mathrm{La}}_{0.7}{\mathrm{Ca}}_{0.3}{\mathrm{MnO}}_{3},$ and ${\mathrm{La}}_{0.7}{\mathrm{Sr}}_{0.3}{\mathrm{MnO}}_{3}.$ The low-energy optical conductivity in the paramagnetic-insulating state of these materials is characterized by a broad maximum near 1 eV. This feature shifts to lower energy and grows in optical oscillator strength as the temperature is lowered into the ferromagnetic state. It remains identifiable well below ${T}_{c}$ and transforms eventually into a Drude-like response. This optical behavior and the activated transport in the paramagnetic state of these materials are consistent with a Jahn-Teller small polaron. The optical spectra and oscillator strength changes compare well with models that include both double exchange and the dynamic Jahn-Teller effect in the description of the electronic structure.
Engineering advanced middle ear tissues: where biomimicry of vibrating surfaces connects to optimal organ function (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Residue and Sampling Techniques in Deconvolution (2001)

In this chapter we will study techniques for solving the following general problem, which we will refer to as the Multisensor Deconvolution Problem or MDP: Given a collection of compactly supported distributions, $$\{ {\mu _i}\} _{i = 1}^m \subseteq \mathcal{E}\prime ({\mathbb{R}^d})$$ how can we recover an arbitrary function $$f \in {C^\infty }({\mathbb{R}^d})$$ from the data $$\left\{ {{S_i}} \right\}_{i = 1}^m = \left\{ {f*{\mu _i}} \right\}_{i = 1}^m?$$ The solution technique that we consider involves the construction of deconvolvers. These come in a variety of types but are essentially a collection of distributions which (1) depend only on the convolvers $$\left\{ {{\mu _i}} \right\}_{i = 1}^m$$ and (2) allow for the solution of the MDP with only simple linear operations on the data $$\left\{ {{\mu _i}} \right\}_{i = 1}^m$$
[Effects of Ligusticum wallichii on the plasma and CSF levels of dynorphin A1-13 in rabbits under acute experimental cerebral ischemia]. (1990)

By occluding the bilateral carotid arteries of rabbits to produce bilateral partial cerebral ischemia, and by using radioimmunoassays to measure the levels of dynorphin A1-13 like immunoreactivity (ir-Dyn A1-13) in plasma and cerebrospinal fluid (CSF), the authors find that the levels of ir-Dyn A1-13 in plasma and CSF have significantly increased (P less than 0.01) after cerebral ischemia appears. The result of the Ligusticum wallichii Franch (Ligusticum) pretreatment to the test-group shows a definite improvement of the changes of ir-Dyn A1-13 levels in plasma and CSF. The severity of brain ischemic damage and neurologic dysfunction in Ligusticum-treated animals is lighter than that of saline-treated group, too. In this study, some new approaches are explored to explain the pathophysiology of cerebral ischemia and the mechanisms by which Ligusticum prevents and treats cerebral ischemia.
Sparse Matrix Reconstruction Based on Sequential Sparse Recovery for Multiple Measurement Vectors (2021)

This paper considers recovery of two-dimensional (2D) sparse signals from incomplete measurements. The 2D sparse signals can be reconstructed by solving a sparse representation problem for Multiple Measurement Vectors (MMV). However, the extension of the sparse recovery algorithms to the MMV case may be inefficient if the vectors do not have the same sparsity profile. In this paper, a sequential sparse recovery (SSR) algorithm is proposed to reconstruct the two-dimensional (2D) sparse matrix. The sparsity of the matrix is much reduced after down-sampling observation and the sparse matrix can be reconstructed after sequential observations and reconstructions. Simulation results verify the effectiveness of the proposed method in 2D sparse signal reconstruction.
Quantifier elimination by cylindrical algebraic decomposition based on regular chains (2014)

A quantifier elimination algorithm by cylindrical algebraic decomposition based on regular chains is presented. The main idea is to refine a complex cylindrical tree until the signs of polynomials appearing in the tree are sufficient to distinguish the true and false cells. We report on an implementation of our algorithm in the RegularChains library in Maple and illustrate its effectiveness by examples.
ChemInform Abstract: Total Synthesis and Chemical Design of Useful Glycosidase Inhibitors (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Flexibility of the zeolite RHO framework: in situ x-ray and neutron powder structural characterization of divalent cation-exchanged zeolite RHO (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlexibility of the zeolite RHO framework: in situ x-ray and neutron powder structural characterization of divalent cation-exchanged zeolite RHODavid R. Corbin, L. Abrams, G. A. Jones, M. M. Eddy, W. T. A. Harrison, G. D. Stucky, and D. E. CoxCite this: J. Am. Chem. Soc. 1990, 112, 12, 4821–4830Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/ja00168a029https://doi.org/10.1021/ja00168a029research-articleACS PublicationsRequest reuse permissionsArticle Views558Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The retinal oxysterol pathway: a unifying hypothesis for the cause of age-related macular degeneration (2009)

The toxic role of 7-ketocholesterol and existing pathways for its neutralization may point the way to a unified theory that explains the cause of age-related macular degeneration and points towards novel therapeutic interventions.
Evidence for a Role of the Ubiquitin-Proteasome Pathway in Pancreatic Islets (2006)

The ubiquitin-proteasome pathway is crucial for protein turnover. Part of the pathway involves deubiquitination, which is carried out by cystein proteases known as ubiquitin COOH-terminal hydrolases. The isoform Uch-L1 was found to be present in large amounts in rat islets by immunostaining, Western blot analysis, and RT-PCR. Culturing islets in high glucose concentrations (16.7 mmol/l) for 24 h led to decreased gene expression. Exposure to chronic hyperglycemia following 90% partial pancreatectomy also led to reduced Uch-L1 expression. Expression of other members of the ubiquitin-proteasome pathway studied after culturing islets at high glucose concentrations revealed little change except for modest declines in parkin, human ubiquitin-conjugating enzyme 5 (UbcH5), and beta-TRCP (transducin repeat-containing protein). With the pancreatectomy model, expression of polyubiquitin-B and c-Cbl were increased and E6-associated protein was reduced. Further insight about the proteasome pathway was obtained with the proteasome inhibitor lactacystin, which in short-term 2-h experiments enhanced glucose-induced insulin secretion. An important role for the ubiquitin-proteasome pathways in beta-cells is suggested by the findings that changes in glucose concentration influence expression of genes in the pathway and that blockade of the proteasome degradation machinery enhances glucose-stimulated insulin secretion.
Standardized uptake values and attenuation correction in 18F‐sodium fluoride PET of the equine foot and fetlock (2022)

Maximal standardized uptake values (SUV<sub>max</sub> ) are commonly used for the interpretation of PET studies. Limited information regarding the SUV<sub>max</sub> of <sup>18</sup> F-NaF PET in horses is currently available in the literature. The goals of this retrospective secondary analysis study were to provide reference values for <sup>18</sup> F-NaF SUV<sub>max</sub> in the equine distal extremity and assess the effect of attenuation correction. Nonattenuation corrected (NAC) and CT-based attenuation corrected (CTAC) SUV<sub>max</sub> were obtained from 19 feet and 19 fetlocks. Twenty regions of interest (ROIs) were defined for the foot and 22 for the fetlock. Areas presenting abnormal uptake were excluded. The overall NAC and CTAC SUV<sub>max</sub> were 3.6 +/- 1.5 (mean +/- sd) and 5.0 +/- 1.8 for the feet and 2.9 +/- 1.1 and 3.8 +/- 1.4 for the fetlocks, respectively. The 3 ROIs showing the highest attenuation correction were the navicular center (83.4%), navicular flexor surface (74.9%) and distal phalanx flexor surface (81.3%), whereas attenuation correction was only 5.2% at the dorsal aspect of the proximal phalanx. Significant SUV<sub>max</sub> differences were observed between the different ROIs (P < 0.0001), with the toe (CTAC SUV<sub>max</sub> 7.7 +/- 3.7), dorsal (7.5 +/- 1.9) and central (6.1 +/- 2.2) ROIs of the distal phalanx being significantly higher than those of the other areas. This study demonstrates that attenuation correction affects SUVmax in the equine distal extremity and should be performed if CT data are available. However, as the maximal attenuation correction results in less than doubling the signal intensity, nonattenuation corrected images likely remain relevant for subjective clinical interpretation.
ChemInform Abstract: A NEW SYNTHESIS OF 1,7‐DIOXASPIRO(5.5)UNDECANES. APPLICATION TO A RECTAL GLAND SECRETION OF THE OLIVE FRUIT FLY (DACUS OLEAE) (1984)

Abstract Das Organolithio‐cuprat (II) reagiert mit dem Epoxid (III) zum Substitutionsprodukt (IV), aus dem isomere Spirocyclen (V) gewonnen werden können.
Buoyancy Effects in Forced-Convection Flow and Heat Transfer (1969)

An analysis is made for the effects of buoyancy forces in laminar forced-convection on a vertical flat plate. In general, since it is difficult to obtain an exact solution, an approximate similarity solution is given by introducing the assumption that a role of Gr/Re2 in stream function, [numerical formula] is negligibly small as compared with η. The validity of this assumption is examined by comparing with the experimental data of Kliegel. Numerical calculations are performed for both the constant fluid properties and the variable fluid properties, and the results are compared with Szewczyk's solution previously obtained by perturbation analysis. The velocity and temperature distribution, the friction factor and heat transfer coefficient are given for various values of the parameter Gr/Re2.
Hand Shape Classification with a Wrist Contour Sensor - (Comparison of Feature Types and Observation of Resemblance among Subjects). (2012)

Hand gesture can express rich information. However, existing hand shape recognition methods have several problems. In order to utilize hand gesture in a home automation, we have focused on ”wrist contour” , and have developed a wristwatch-type device that measures wrist contour using photo reflector arrays. In this paper, we try on two challenges: the first is improvement of the hand shape recognition performance, and the second is making clear the effect of personal difference and finding a key to overcome the difference. We collect wrist contour data from 28 subjects and conduct two kinds of experiments. As for the first challenge, three different feature types are compared. The experimental results extract several important contour statistics and the classification rate itself is also improved by introducing multiple subjects’ data for training. As for the second challenge, we compose a resemblance matrix to evaluate resemblance among subjects. The results indicate that training data selection is important to improve the classification performance, especially when we don’t have time to collect enough training data for a new user.
Expression of mRNA for Interferon-Gamma, Interleukin-10, and Interleukin-12 (p40) in Normal Gastric Mucosa and in Mucosa Infected withHelicobacter pylori (1997)

IFN-gamma and IL-10 expressions in healthy mucosa may indicate a biologic role in a healthy state. IL-12 expression in mucosa was related to the presence of bacterial stimulant and therefore resembles proinflammatory cytokines.
Fundamentals of Tracking (2010)

This chapter contains sections titled: Introduction Impact of User Mobility on Positioning Mobility Models Tracking Moving Devices Conclusions
Capacity limits and matching properties of integrated capacitors (2002)

Theoretical limits for the capacitance density of integrated capacitors with combined lateral and vertical field components are derived. These limits are used to investigate the efficiency of various capacitive structures such as lateral flux and quasifractal capacitors. This study leads to two new capacitor structures with high lateral-field efficiencies. These new capacitors demonstrate larger capacities, superior matching properties, tighter tolerances, and higher self-resonance frequencies than the standard horizontal parallel plate and previously reported lateral-field capacitors, while maintaining comparable quality factors. These superior qualities are verified by simulation and experimental results.