gebhart/patrepeval huggingface dataset:
Beyond home and school: community-based media and youth voice on pandemic life in the United States (2022)

Across the United States, educational institutions struggled to respond to the pandemic. In one program, black female teens gathered each week with their mentors, a group of five black female entrepreneurs, to design a product that responded to a local problem in their communities. The practice of being vulnerable and transparent extended into their TikToks. One of the facilitators, a documentary filmmaker, described how in the first weeks of the five week program the group “spent a lot of time building community, having more kinda deep conversations”, which were a jumping off point for developing pitches. After months of “Zoom school” and mandated learning apps, it’s notable that when given the opportunity to make media, youth in both of these examples opted to focus on making their voices heard when it came to their experiences of the pandemic – something especially important as youths’ locus of power and agency have been heavily disrupted by it.
ChemInform Abstract: Unusual Enolizations in 19‐Nor‐3‐ketosteroids. (1986)

Abstract Östradion (I) ergibt die Phcnylselenoether (II)‐(IV), die nach Oxidation zu den entsprechenden Seleninylverbindungen zu den Steroiden (V) bis (VII) eliminieren.
Optimum mean-square error use of convolutional codes (1985)

The <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</tex> input and output digits of a rate <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(k/n)</tex> linear convolutional code over a finite field GF <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(q)</tex> are related to a finite set of integers by a <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</tex> -ary expansion. The mean-square error criterion is used to simultaneously select the optimum encoder and decoder rules. This optimization is performed over all one-to-one generalized encoding rules and all decoding functions that map into the real numbers. The optimal design procedure relies upon generalized Fourier transforms, and it is shown that the encoder part of the optimum pair of rules can be taken as a linear function when the input space of symbols is viewed in a natural algebraic setting. The decoder part is a conditional mean estimator coupled with a rounding operation. One method of implementing the decoder uses the nonlinear combination of filter functions defined in the generalized frequency domain.
Open source application spaces (2005)

Building on the success of the first four workshops in the series, which were held at ICSE 2001 (Toronto), ICSE 2002 (Orlando), ICSE 2003 (Portland) and ICSE 2004 (Edinburgh), the 5th Workshop on Open Source Software Engineering, ("Open Source Application Spaces") brought together researchers and practitioners for the purpose of building a roadmap of the ways in which various computing application spaces have been impacted by open source software and also by open source development methods, tools and organizational structures.
Functional Interaction between the c-Abl and Arg Protein-tyrosine Kinases in the Oxidative Stress Response (2003)

The Abl family of mammalian nonreceptor tyrosine kinases consists of c-Abl and Arg. Recent work has shown that c-Abl and Arg are activated in the cellular response to oxidative stress. The present studies demonstrate that reactive oxygen species (ROS) induce the formation of c-Abl and Arg heterodimers. The results show that the c-Abl SH3 domain binds directly to a proline-rich site (amino acids 567-576) in the Arg C-terminal region. Formation of c-Abl.Arg heterodimers also involves direct binding of the Arg Src homology 3 domain to the C-terminal region of c-Abl. The results further demonstrate that the interaction between c-Abl and Arg involves c-Abl-mediated phosphorylation of Arg. The functional significance of the c-Abl-Arg interaction is supported by the demonstration that both c-Abl and Arg are required for ROS-induced apoptosis. These findings indicate that ROS induce c-Abl.Arg heterodimers and that both c-Abl and Arg are necessary as effectors in the apoptotic response to oxidative stress.
QoS monitoring in high performance environments (1996)

Forthcoming applications, especially distributed multimedia and interactive applications, have stringent requirements on the quality of the communication service. Therefore, an integrated Quality-ofService (QoS) management is needed including all involved components to guarantee a communication service from application to application. One promising approach to guarantee a certain level of service uses the reservation of communication resources and the assignment of these resources to individual data streams based on the requested service. However, often it is not sufficient to reserve resources only. Additionally, monitoring of QoS parameters must be applied to ensure that the negotiated QoS is achieved. Within this paper, the design and implementation of a QoS monitor for communication subsystems is presented. 1. Introduction Emerging communication subsystems need to integrate concurrent support for an increasing variety of applications, including audio, video, and conventio...
Worst case bin packing for OTN electrical layer networks dimensioning (2011)

The OTN (Optical Transport Network) standard, defined by ITU-T Recommendation G.709 and G.872, contains a flexible digital hierarchy of ODU (Optical Data Unit) signals. The ODU hierarchy provides sub-wavelength grooming in OTN networks, which is necessary for efficient utilization of the high bit rates of optical channels. When dimensioning the links of a transport network consisting of ODU switches, the packing of lower order ODU signals into higher order ODU signals needs to be taken into account. These networks are expected to be controlled by GMPLS (Generalized MPLS), which puts specific constraints on the dimensioning. We assume that there is no explicit label control and that the GMPLS control plane is using first-fit strategy for making reservations on a link. With these assumptions the link dimensioning problem is defined as deciding how many higher order ODU component links are required on an OTN GMPLS bundled link for first-fit packing of a given set of lower order ODU demands, in any order of arrival. The paper provides strict bounds for ODU hierarchy-specific item and bin sizes. Then, it introduces an extended variant of the dimensioning problem, when lower order ODU connections which are not controlled by GMPLS are also present.
Classification and Reconstruction From Random Projections for Hyperspectral Imagery (2012)

There is increasing interest in dimensionality reduction through random projections due in part to the emerging paradigm of compressed sensing. It is anticipated that signal acquisition with random projections will decrease signal-sensing costs significantly; moreover, it has been demonstrated that both supervised and unsupervised statistical learning algorithms work reliably within randomly projected subspaces. Capitalizing on this latter development, several class-dependent strategies are proposed for the reconstruction of hyperspectral imagery from random projections. In this approach, each hyperspectral pixel is first classified into one of several pixel groups using either a conventional supervised classifier or an unsupervised clustering algorithm. After the grouping procedure, a suitable reconstruction method, such as compressive projection principal component analysis, is employed independently within each group. Experimental results confirm that such class-dependent reconstruction, which employs statistics pertinent to each class as opposed to the global statistics estimated over the entire data set, results in more accurate reconstructions of hyperspectral pixels from random projections.
Soluble CD73 Can Predict Future Organ Failure in Pancreatitis (2014)

Department of Surgery, Pennsylvania State University, State College, PA * See also p. 2556. The authors have disclosed that they do not have any potential conflicts of interest.
A Proliferative p53-Responsive Element Mediates Tumor Necrosis Factor Alpha Induction of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat (1995)

Transforming mutants of the p53 tumor suppressor gene can positively regulate transcription from several promoters that do not contain known p53 binding sites. Here, we report the identification of a novel p53 binding site in the human immunodeficiency virus long terminal repeat that specifically mediates mutant p53 transactivation. This DNA element was bound by endogenous Jurkat p53 when these cells were stimulated by tumor necrosis factor. Mutation of this sequence inhibited p53 transactivation and tumor necrosis factor inducibility of the human immunodeficiency virus type 1 long terminal repeat. In addition, this DNA element was found to be sufficient to confer mutant p53 responsiveness on a heterologous minimal promoter. It has been hypothesized that transforming mutants of p53 represent a proliferative conformational stage that can be adopted by the native protein under stimulation by growth factors. The data presented suggest that proliferative and antiproliferative p53 conformations recognize different DNA binding sites in order to mediate distinct biological functions. Thus, transforming mutants of p53 that fold into the proliferative conformation would favor proliferative over antiproliferative functions.
Predicting Length of Stay among Patients Discharged from the Emergency Department—Using an Accelerated Failure Time Model (2017)

The influential factors on the ED LOS in discharged patients were identified and quantified in the current study. The model's predicted ED LOS may provide useful information for physicians or patients to better anticipate an individual's LOS and to help the administrative level plan its staffing policy.
A phase 1/2 study of the highly selective EGFR inhibitor, BLU-701, in patients with EGFR-mutant non–small cell lung cancer (NSCLC). (2022)

TPS9142 Background: Although 3rd-generation tyrosine kinase inhibitors (TKIs), such as osimertinib, are highly effective in front-line metastatic EGFR-mutated ( EGFRm) NSCLC, treatment resistance ultimately occurs, including the emergence of the on-target C797X mutation for which there are no approved TKIs. BLU-701 is an investigational, reversible, brain-penetrant, wildtype-sparing oral TKI with nanomolar potency on common activating (exon 19 deletion and L858R) and C797X resistance mutations (Tavera L et al. AACR 2022). BLU-701 has shown promising preclinical data, including antitumor central nervous system (CNS) activity that may improve patient outcomes. Additionally, combining BLU-701 with standard of care therapies may provide enhanced disease control across multiple lines of treatment, including against heterogenous tumors, in patients with EGFRm NSCLC. Methods: HARMONY (NCT05153408) is an ongoing, global phase 1/2, open-label, first-in-human study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of BLU-701 as a monotherapy or in combination with osimertinib or platinum-based chemotherapy in patients with EGFRm NSCLC. Key inclusion criteria include patients ≥18 years of age with metastatic EGFRm NSCLC; Eastern Cooperative Oncology Group performance status 0–1; and previous treatment with ≥1 EGFR-targeted TKI. Patients in the phase 2 monotherapy part must harbor an EGFR C797X resistance mutation (locally assessed). Key exclusion criteria are tumors harboring EGFR T790M mutations, EGFR exon 20 insertions, or other known driver alterations, including KRAS, BRAF V600E, NTRK1/2/3, HER2, ALK, ROS1, MET, or RET. Phase 1 primary endpoints are maximum tolerated dose, recommended phase 2 dose (RP2D), and safety. The phase 2 primary endpoint is overall response rate (ORR) by RECIST 1.1. Secondary endpoints include ORR (phase 1), duration of response, and PK/PD (phase 1 and phase 2); disease control rate, progression-free survival, overall survival, antitumor CNS activity, and safety (phase 2). The phase 1 dose escalation will adopt a Bayesian optimal interval design. Patients will be enrolled into 3 treatment cohorts: part 1A (n≈40–80; BLU-701), part 1B (n≈35; BLU-701 + osimertinib), and part 1C (n≈18; BLU-701 + carboplatin and pemetrexed). Patients in the phase 2 dose expansion (n≈24) will be treated at the RP2D of BLU-701 as monotherapy. Patients may receive treatment until disease progression, unacceptable toxicity, or other discontinuation criteria are met. Enrollment in this study has started, and sites will be open across North America, Europe, and Asia. Clinical trial information: NCT05153408.
Phylogeography and species delimitation of Cherax destructor (Decapoda: Parastacidae) using genome-wide SNPs (2019)

Cherax is a genus of 58 species of decapod crustaceans that are widespread across Australia and New Guinea. We use single-nucleotide polymorphisms (SNPs) to examine phylogeographic patterns in the most widespread species of Cherax, namely, C. destructor, and test the distinctiveness of one undescribed species, two C. destructor subspecies, previously proposed evolutionarily significant units, and management units. Both the phylogenetic analyses and the analysis of fixed allelic differences between populations support the current species-level taxonomy of C. setosus, C. depressus, C. dispar and C. destructor, the distinctiveness of C. destructor albidus and C. d. destructor and the existence of one undescribed species. The two populations of C. d. albidus from the Glenelg and Wimmera rivers were significantly distinct, with eight diagnostic differences (&amp;lt;1% fixed differences, null expectation is four fixed differences), but this low level of divergence is interpreted as within the range that might be expected of management units, that is, among allopatric populations of a single species or subspecies. A southern clade of C. d. destructor comprising the Murray River and its tributaries upstream from its confluence with the Darling River is genetically distinct from a northern clade comprising populations from the Lake Eyre Basin, the northern half of the Murray–Darling Basin (Darling River catchment) and the Lower Murray River below the Darling confluence.
Formation of intermolecular disulfide bonds on nascent immunoglobulin polypeptides. (1979)

The initial step of intermolecular covalent assembly of immunoglobulins molecules involves formation of heavy chain-light chain or heavy chain-heavy chain disulfide bonds. Using QAE-Sephadex chromatography to isolate microsomal nascent polypeptides, we have shown that this initial step of intermolecular covalent assembly occurs, to a substantial extent, on nascent heavy chains, as well as on completed heavy chains as previously demonstrated by others. In MPC 11 mouse myeloma cells, completed light chains are assembled covalently to nascent heavy chains, whereas in MOPC 21 mouse myeloma cells, completed heavy chains are assembled covalently to nascent heavy chains. These results are consisted with the heavy-light half-molecule being the major initial intermediate in the assembly of MPC 11 IgG2b and heavy-heavy dimer being the major initial intermediate formed in assembly of MOPC 21 IgG1. The nascent MPC 11 heavy chain must be at least 38,000 daltons in size before assembly with the light chain occurs, even though the heavy chain cysteine involved in this disulfide bond is 131 residues (approximately 15,000 daltons) from the NH2 terminus. In addition, pulse-chase labeling studies of MPC 11 cells have shown that the assembly of completed light chains with the nascent heavy chain must occur within a few minutes of the synthesis of the light chain even though a large excess of unassembled MPC 11 light chains remain inside the cell for an average time of 2 h before being secreted.
Supplementary Table S1 from The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer (2023)

&lt;p&gt;PDF file 70K, This table contains the IC50 values of in vitro cell survival assay for crizotinib or ceritinib in engineered EML4-ALK mutant Ba/F3 cells corresponding to Fig 4A&lt;/p&gt;
On the Reading of Tables of Contents (2008)

This paper presents a framework for understanding tables of contents (TOC) of books, journals, and magazines. We propose a universal logical structure representation in terms of a hierarchy of entries, each of which may contain a descriptor and a locator. We enumerate graphical and perceptual cues that provide cues to parsing of tables of contents in terms of this formalism. We make initial suggestions about the form of evaluation metrics for comparing ground truthed tables of contents with the output of recognition algorithms. Typical and a typical tables of contents are used throughout to illustrate significant phenomena that must be dealt with in principled ways in any general TOC interpretation scheme. Finally we discuss implications of our observations on the design of recognition algorithms.
High Tg and fast curing epoxy-based anisotropic conductive paste for electronic packaging (2016)

Herein, our main objective is to prepare the fast curing epoxy system with high glass transition temperature (Tg) by incorporating the multifunctional epoxy resin into the mixture of diglycidyl ether of bisphenol A (DGEBA) as a major epoxy component and aromatic diamine as a hardener. Furthermore, the curing behavior as well as thermal and thermomechanical properties were investigated by differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA) and thermomechanical analysis (TMA). It was found that Tg obtained from tan δ of DGEBA/aromatic diamine system increased from 100 °C to 205 °C with the presence of 30 percentage by weight of multifunctional epoxy resin. Additionally, the isothermal DSC results showed that the multifunctional epoxy resin can accelerate the curing reaction of DGEBA/aromatic diamine system. Namely, a high degree of curing (∼90%) was achieved after a few minutes of curing at low temperature of 130 °C, owing to a large number of epoxy ring of multifunctional epoxy resin towards the active hydrogen atoms of aromatic diamine.
Simultaneous Control and Trajectory Estimation for Collision Avoidance of Autonomous Robotic Spacecraft Systems (2022)

We propose factor graph optimization for simultaneous planning, control, and trajectory estimation for collision-free navigation of autonomous systems in environments with moving objects. The proposed online probabilistic motion planning and trajectory estimation navigation technique generates optimal collision-free state and control trajectories for autonomous vehicles when the obstacle motion model is both unknown and known. We evaluate the utility of the algorithm to support future autonomous robotic space missions.
Optical Organophosphate Sensor Based upon Gold Nanoparticle Functionalized Fumed Silica Gel (2007)

We report on the creation of a high surface area, chemically selective material for the efficient adsorption of organophosphate and organophosphonate species. Using silica microparticles in conjunction with gold nanoparticles and surface modification chemistry, we have demonstrated a material with a binding constant for organophosphonates and organophosphates (OPPs) of K=2x10(6) M-1. The binding of OPPs to the modified gold nanoparticles appears as a spectral shift in the gold nanoparticle resonance. The sensitivity of this technique is limited by scattering losses of suspensions of the particles, and we report on how this sensitivity can be recovered to a significant extent by the use of solvents with a refractive index close to that of the silica particles.
Biochemical, biophysical, and biological properties of densonucleosis virus. I. Structural proteins (1976)

The polypeptide composition of highly purified densonucleosis virus was studied by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The viral proteins showed a different behavior in sodium dodecyl sulfate-gels in comparison with the marker proteins. Therefore, the molecular weights were estimated by analyzing the retardation of the electrophoretic mobility of these proteins in gels with increasing polyacrylamide concentrations. Four structural proteins with molecular weights of 49,000, 58,500, 69,000, and 98,000 were found, ant they were designated p49, p59, p69, and p98, respectively. There are several indications that p98 is a dimer of p49. The relative quantity of the structural proteins in a virion suggests that at least p49 (accounting for +/-70% of total protein mass) is a capsid protein and that there will be 12 capsomers per virion.
The association between FcgRIIIB polymorphisms and systemic lupus erythematosus in Korea (2005)

Polymorphisms of FcgammaR have been proposed as genetic factors that influence susceptibility to SLE. FcgammaRIIIB polymorphism in systemic lupus erythematosus (SLE) have been studied in various populations, but the results were inconsistent. The aim of this study was to determine the association of FcgammaRIIIB polymorphism in Korean lupus patients. One-hundred and eighty-three SLE patients (166 female, 17 male) meeting 1982 ACR criteria and 300 Korean disease-free controls were enrolled. Genotyping for the FcgammaRIIIB NA1/NA2 was performed by PCR of genomic DNA using allele-specific primers. There was no significant skewing in the distribution of the three FcgammaRIIIB genotypes, and alleles between SLE and the controls. The frequency of FcgammaRIIIB genotypes in SLE patients and controls was FcgammaRIIIB NA1/NA1 27.9% versus 26%, NA1/NA2 55.2% versus 51.7%, NA2/NA2 16.9% versus 22.3%, respectively. The gene frequencies of NA1 allele were 0.56 in the SLE and 0.52 in controls, respectively. Among clinical manifestations, thrombocytopenia was more common in FcgammaRIIIB NA2/NA2 genotype (P = 0.04, OR 2.4, 95% CI 1.0-5.4), and NA2 allele (P = 0.03, OR 1.7, 95% CI 1.1-2.8). Although FcgammaRIIIB polymorphism was not associated with the development of SLE in Korean, thrombocytopenia was associated with FcgammaRIIIB NA2/NA2 genotype, and NA2 allele.
Evaluation of the Costs and Benefits of EU Wide Emission Trade for Finland (2002)

This study assesses the economic impacts of the proposed EU-wide emission trade both on the European union as a whole and on Finland in particular. The study utilises the global GTAP-E- CGE-model to analyse Europe-wide impacts and a Finland-specific, hybrid, CGE-model to study the impacts on the Finnish economy. The main finding of the study is that at a European level, emission trade appears to be very beneficial. However, emission trade along the lines of the EU Emission trade directive would not necessarily lower the macroeconomic costs of green house gas abatement in Finland, since it might very well misallocate quotas among the trading sectors on the one hand, and between the trading sectors and the rest of the economy on the other. Abatement costs might be lowered within some of the trading sectors, however. The study focuses on manufacturing of metals in particular and finds that emission trading would lower abatement costs in these industries only if permit prices were very low.
Pose-based composition improvement for portrait photographs (2017)

This paper studies the composition of portrait paintings and develops an algorithm to improve the composition of portrait photographs. The study of portrait paintings shows that placement of the face and the figure in portrait paintings is pose-related. Based on this observation, this paper develops an algorithm to improve the composition of a portrait photograph by learning the placement of the face and the figure from an example portrait painting. The example portrait painting is selected based on the similarity of its figure pose to that of the input photograph. This similarity measure is modeled as a graph matching problem. Finally, space cropping is performed using an optimization function. Experimental results and a user study demonstrate that the proposed pose-based improvement is preferred more than rule-based methods.