gebhart/patrepeval huggingface dataset:
The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer (2016)

Epithelial ovarian cancer (EOC) has poor prognosis and rapid recurrence because of widespread dissemination of peritoneal metastases at diagnosis. Multiple pathways contribute to the aggressiveness of ovarian cancer, including hypoxic signaling mechanisms. In this study, we have determined that the hypoxia-inducible histone demethylase KDM4B is expressed in ∼60% of EOC tumors assayed, including primary and matched metastatic tumors. Expression of KDM4B in tumors is positively correlated with expression of the tumor hypoxia marker CA-IX, and is robustly induced in EOC cell lines exposed to hypoxia. KDM4B regulates expression of metastatic genes and pathways, and loss of KDM4B increases H3K9 trimethylation at the promoters of target genes like LOXL2, LCN2 and PDGFB. Suppressing KDM4B inhibits ovarian cancer cell invasion, migration and spheroid formation in vitro. KDM4B also regulates seeding and growth of peritoneal tumors in vivo, where its expression corresponds to hypoxic regions. This is the first demonstration that a Jumonji-domain histone demethylase regulates cellular processes required for peritoneal dissemination of cancer cells, one of the predominant factors affecting prognosis of EOC. The pathways regulated by KDM4B may present novel opportunities to develop combinatorial therapies to improve existing therapies for EOC patients.
Characterization of CuO/ZnO/Al<sub>2</sub>O<sub>3</sub> Catalyst for Methanol Synthesis (2011)

The property of CuO/ZnO/Al 2 O 3 catalysts for methanol synthesis was investigated by means of XRD, H 2 -TPR and DTG. The results show that the thermal activity of the self-made CuO/ZnO/Al 2 O 3 catalyst is better than the commercial catalyst C302 and displayed stable property after 180h application. The catalyst calcinated revealed strong interaction between CuO and ZnO, and the dispersion of CuO crystal particular was uniform. There was a small amount of carbon deposition on the surface of CuO/ZnO/Al 2 O 3 catalyst after synthesis reaction. For synthesis of methanol with self-made catalyst in fixed reactor from the analog components of reformed bluecoke furnace gas, the space time yield and selectivity of coarse methanol respectively reached 1.5451 g·g -1 ·h -1 and 99.6143% under the conditions of temperature of 240°C, pressure of 5.5MPa and space velocity of 12000h -1 .
A compact electron cyclotron resonance negative hydrogen ion source for evaluation of plasma electrode materials (2020)

A compact ion source that produces hydrogen plasma with an electron cyclotron resonance (ECR) configuration combined with a 2-stage extraction system with a single aperture of 6 mm diameter has been designed and built to study the performance of different materials as the plasma electrode (PE) of a negative hydrogen ion source. The source has the capability to electrically bias the PE with respect to the ECR plasma. The first experiment with low ECR power input (less than 40 W) was carried out. The PE of the C12A7 electride showed the largest H<sup>-</sup> current among aluminum, molybdenum, and the C12A7 electride.
Ulnar Nerve Surgery (2000)

Summary: Cubital tunnel syndrome is a relatively common entity among compression neuropathies of the upper extremities. Different techniques to treat failure of conservative treatment have been described in the literature. These procedures are based on decompressing of the nerve alone or in combination with placement in a new physiologic bed. In this paper, we review the surgical options for treatment of the cubital tunnel syndrome.
IFAD RESEARCH SERIES 62 - The spillover effects of seed producer groups on non-member farmers in mid-hill communities of Nepal (2020)

Research Series Issue 62: The spillover effects of seed producer groups on non-member farmers in mid-hill communities of Nepal June 2020 Rice farmers in the mid-hills region of Nepal are vulnerable to drought, which can drastically reduce yields. Stress-tolerant rice varieties (STRVs) can mitigate this vulnerability, as can having a high seed replacement rate and using best management practices (BMPs) in rice cultivation. In 2013, IFAD established and trained 12 seed producer groups (SPGs) across three districts in Nepal to improve local access to STRV seed. This paper presents propensity-score–weighted regressions used to estimate the spillover effects of SPGs on the adoption of STRVs and BMPs, as well as on the seed replacement rate of non-member households in villages with an SPG, or that are next to a village with an SPG, compared to randomly selected villages in the region.
Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8 (2018)

A majority of the potential health benefits of green tea, including the potential to prevent cognitive decline, have been attributed to epigallocatechin gallate (EGCG). Sunrouge is a green tea cultivar that contains EGCG and several other bioactive components such as quercetin, myricetin, cyanidin and delphinidin. We compared the effects of Sunrouge and Yabukita, the most popular Japanese green tea cultivar, on cognitive function in the senescence-accelerated mouse Prone8. These mice were fed an experimental diet containing Sunrouge extract (SRE) or Yabukita extract (YBE). SRE feeding significantly prevented cognitive decline, whereas YBE feeding had little effect. Moreover, SRE feeding prevented elevation of the amyloid-β42 level while improving the gene expression of neprilysin and decreasing beta-site APP-cleaving enzyme 1 in the brain. These preventive effects of SRE against cognitive decline were attributed to the characteristic composition of Sunrouge and strongly suggest that consumption of this cultivar could protect against age-related cognitive decline.
Nth-order dynamics target observability from angle measurements (1988)

Necessary and sufficient conditions are presented for the observability of the target's Nth-order dynamics, given direction measurements. The derivations are extremely simple and do not require the examination of an observability matrix or nonlinear differential equations. Previously published observability requirements for the first-order dynamics are shown to be necessary but not sufficient.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Biological roles of glycans (2016)

Simple and complex carbohydrates (glycans) have long been known to play major metabolic, structural and physical roles in biological systems. Targeted microbial binding to host glycans has also been studied for decades. But such biological roles can only explain some of the remarkable complexity and organismal diversity of glycans in nature. Reviewing the subject about two decades ago, one could find very few clear-cut instances of glycan-recognition-specific biological roles of glycans that were of intrinsic value to the organism expressing them. In striking contrast there is now a profusion of examples, such that this updated review cannot be comprehensive. Instead, a historical overview is presented, broad principles outlined and a few examples cited, representing diverse types of roles, mediated by various glycan classes, in different evolutionary lineages. What remains unchanged is the fact that while all theories regarding biological roles of glycans are supported by compelling evidence, exceptions to each can be found. In retrospect, this is not surprising. Complex and diverse glycans appear to be ubiquitous to all cells in nature, and essential to all life forms. Thus, >3 billion years of evolution consistently generated organisms that use these molecules for many key biological roles, even while sometimes coopting them for minor functions. In this respect, glycans are no different from other major macromolecular building blocks of life (nucleic acids, proteins and lipids), simply more rapidly evolving and complex. It is time for the diverse functional roles of glycans to be fully incorporated into the mainstream of biological sciences.
Intrinsic Dimensionality Estimation of Submanifolds in Euclidean space (2005)

We present a new method to estimate the intrinsic dimensionality of a submanifold M in Euclidean space from random samples. The method is based on the\nconvergence rates of a certain U-statistic on the manifold. We solve at least partially the question of the choice of the scale of the data.\nMoreover the proposed method is easy to implement, can handle large data sets and performs very well even for small sample sizes. We compare the\nproposed method to two standard estimators on several artificial as well as real data sets.
In vitro interactions between low density lipoprotein from hyperapobetalipoproteinemic plasma and arterial wall proteoglycans. (1992)

To examine the interactions of low density lipoprotein-B (LDL-B) with proteoglycans (PG) in vitro.The PG were isolated from human aortas, removed at autopsy by a combination of extraction with 4M guanidine-Tris buffer containing protease inhibitors and fractionation on a DEAE-Sephacel ion-exchange chromatography column. LDL and LDL-B from healthy or hyperapobetalipoproteinemic sera, respectively, were isolated by standard density flotation techniques followed by radioiodination. Radiolabelled lipoproteins (LP) were incubated with proteoglycans at 4 or 37 degrees C in a low ionic strength buffer with or without addition of polyethylene glycol (PEG) which was used to enhance precipitation of the resulting LP-PG complexes.Data revealed that a specific ratio of LP to PG is a prerequisite for optimal interactions between these macromolecules. Further, it was observed that LDL-B forms fewer precipitable complexes than normal LDL at 4 degrees C. However, at physiological temperature or with the addition of PEG, precipitation of the two LDLs was equal.LDL and LDL-B showed equal reactivity with PG in terms of precipitable complexes.
Optimization of a door seal structure of a microwave oven using a FDTD method (2008)

Abstract The optimum door seal configuration to prevent radiation leakage from a microwave oven is still a manufacturing concern. Here, we propose a numerical algorithm to simulate the radiation propagation along a door seal structure using the finite‐difference time domain method, which is used for a priori shielding efficiency tests. The results agree with experimental data. The critical dimensions of the choke structure were found and high shielding is anticipated for a simpler choke structure. Copyright © 2008 John Wiley &amp; Sons, Ltd.
AbeI, a restriction endonuclease from Azotobacter beijerinckii, which recognizes the asymmetric heptanucleotide sequence 5'-CCTCAGC-3'(-5/-2) (1998)

A new restriction endonuclease Abe I has beenisolated from Azotobacter beijerinckii. This enzymerecognizes the asymmetric heptanucleotide sequence 5'-CCTCAGC-3' and cleaves within it symmetrically at positions -5/-2 in the opposing strands, producing three base protruding 5'-ends.
Intelligent control of mechatronic systems (2003)

This talk is dedicated to intelligent control of mechatronic systems. After a brief review of fuzzy logic and neural network systems, two main tools used for intelligent control, and some basic control concepts and methodologies, intelligent control is presented for two typical mechatronic systems, servo mechanisms and robotic systems by fully exploiting the physical properties of the systems. For servo mechanisms, both adaptive friction compensation and adaptive neural network (NN) control are investigated under various conditions. For robotic systems, intelligent control is discussed for rigid robots, flexible joint robots, flexible link robots, and smart materials flexible robots.
Renal Transport of Organic Acids and Bases in Genetically Obese Mice (1975)

Accumulation of p-aminohippurate (PAH) and N-methylnicotinamide (NMN) by renal cortical slices was used to estimate transport capacity for organic anions and cations, respectively. In a previous study, renal organic anion transport appeared to be selectively depressed in animals rendered obese by high fat feeding. However, the effects of obesity could not be discretely separated from the effects of the 30% fat diet used to produce the obesity. Genetically obese hyperglycemic mice provided a model to determine the effect of obesity on renal transport systems without the complication due to diet. Accumulation of both PAH and NMN was depressed in renal cortical slices from genetically obese mice. Addition of plasma from thin or obese animals increased PAH accumulation by slices from thin animals. Accumulation by slices from obese animals was unaffected by addition of plasma. Oxygen consumption with acetate in the medium was less in kidneys from obese mice than kidneys from thin mice. Thus, in addition to inhibition of transport capacity, renal cortex of genetically obese mice has a biochemical defect that prevents response to stimulators. It is concluded that several renal functions are depressed in the genetically obese hyperglycemic mouse. Whether the depressed function results from the obesity or is concomitant with the gene for obesity is as yet undertermined.
The Role of IGSF3 in Cell Adhesion, Proliferation, and Cell Migration (2018)

Abstract Rationale Tetraspanins are cell membrane–spanning proteins that transduce extracellular signals and control cell adhesion via interactions with multiple molecules, including the protein immunoglobulin superfamily, member 3 (IGSF3). Exhibiting a large extracellular domain, and anchored in tetraspanin-enriched microdomains within the plasma membrane, the function of IGSF3 is unknown. Objectives Building on our finding that IGSF3 knockdown in lung epithelial cells increases glucosylceramides, sphingolipids that are known to enhance the stability of tetraspanin complexes, we hypothesized that IGSF3 is critical for cell adhesion. Further, because we found that IGSF3 expression was consistently decreased after cigarette smoke exposure we investigated whether genomic alterations (single-nucleotide polymorphisms [SNPs]) within IGSF3 are present in chronic obstructive pulmonary disease (COPD). Methods To knock down IGSF3, human bronchial epithelial cells (Beas2b) were stably transfected with lentiviral IGSF3-shRNA or control short hairpin RNA and then compared, with respect to cell adhesion, with fibronectin and migration in a scratch wound assay. The role of glucosylceramides in IGSF3 function was tested with GENZ-123346, a pharmacological inhibitor of glucosylceramide synthase. IGSF3 SNPs were evaluated in COPDGene data sets. Results Cells with IGSF3 knockdown did not exhibit increased cell death; on the contrary, they had increased rates of proliferation. However, inhibition of IGSF3 expression markedly increased cell adhesion (&amp;gt;twofold; P &amp;lt; 0.01). This was associated with significantly decreased cell migration (P &amp;lt; 0.01) that was restored on glucosylceramide synthase inhibition. Of the 11 IGSF3 SNPs identified to associate with COPD, rs6703791, in the exon 11 coding region, consisting of a missense A-G mutation, may regulate IGSF3 expression. Conclusions IGSF3 may be required for lung structural cell adhesion and motility by controlling the synthesis of glycosphingolipids. Loss of IGSF3, either through exposure to cigarette smoking, or through mutations, may impair functions that require cell migration, such as lung tissue repair.
Relationship of cell wall composition toin vitro cell wall digestibility of maize inbred line stems (2000)

The phenolic equipment of maize stem tissues was investigated in relation to the feeding value of the detergent fibre components. Sixteen maize inbred lines, including three brown-midrib 3 mutants and their normal counterparts, were selected for highly divergent in vitro cell wall digestibility. These lines were grown during two years. Maize stems were analysed for detergent fibre concentration, esterified and etherified p-hydroxycinnamic acids, lignin content and structure and in vitro digestibility. A large genotypic variation was found for neutral detergent fibre, cell wall phenolic composition and cell wall digestibility. Within the normal maize lines the in vitro neutral detergent fibre digestibility (IVNDFD) of stem fractions was negatively correlated with their Klason lignin content. A multiple regression model based on esterified p-coumaric acid and lignin composition as two explanatory variates accounted for 58% of the IVNDFD variation. In this study, three normal maize inbred lines displaying a lignin content and a cell wall digestibility level close to those observed in the three bm3 lines could be detected, which opens up new breeding avenues. © 2000 Society of Chemical Industry
A Dynamic Embedding Algorithm for Wireless Network Virtualization (2014)

Wireless network virtualization enables multiple virtual wireless networks to coexist on shared physical infrastructure. However, one of the main challenges is the problem of assigning the physical resources to virtual networks in an efficient manner. Although some work has been done on solving the embedding problem for wireless networks, few solutions are applicable to dynamic networks with changing traffic patterns. In this paper we propose a dynamic greedy embedding algorithm for wireless virtualization. Virtual networks can be re-embedded dynamically using this algorithm, enabling increased resource usage and lower rejection rates. We compare the dynamic greedy algorithm to a static embedding algorithm and also to its dynamic version. We show that the dynamic algorithms provide increased performance to previous methods using simulated traffic. In addition we formulate the embedding problem with multiple priority levels for the static and dynamic case.
1-Olefin polymerization at bis(pentamethylcyclopentadienyl)zirconium and -hafnium centers: enantioface selectivity (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Olefin polymerization at bis(pentamethylcyclopentadienyl)zirconium and -hafnium centers: enantioface selectivityLuigi Resconi, Luigi Abis, and Giuseppe FrancisconoCite this: Macromolecules 1992, 25, 25, 6814–6817Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ma00051a014https://doi.org/10.1021/ma00051a014research-articleACS PublicationsRequest reuse permissionsArticle Views407Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Impairing Proliferation of Glioblastoma Multiforme with CD44+ Selective Conjugated Polymer Nanoparticles (2021)

Glioblastoma is one of the most aggressive types of cancer with median survival of only 15 months. Successful therapy is hampered by the existence of treatment resistant populations of stem-like tumour initiating cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable of effectively targeting the TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole (DPP)-based conjugated polymer nanoparticles (CPNs) with an average diameter of 109 nm. The CPN were designed to include fluorescein-conjugated hyaluronic acid (HA), a ligand for the CD44 receptor present on one population of TICs. We demonstrate blood-brain barrier permeability of this system and concentration and cell cycle phase-dependent selective uptake of HA-CPNs in CD44 positive GBM-patient derived cultures. Interestingly, we found that uptake alone decreases stemness, invasive properties and proliferation of the CD44-TIC population in zebrafish PDX models in vivo. This study is the first to show surface moiety-driven selectivity of conjugated polymer nanoparticles in targeting TIC populations in brain cancer.
On Information Leakage in Deduplicated Storage Systems (2016)

Most existing cloud storage providers rely on data deduplication in order to significantly save storage costs by storing duplicate data only once. While the literature has thoroughly analyzed client-side information leakage associated with the use of data deduplication techniques in the cloud, no previous work has analyzed the information leakage associated with access trace information information (e.g., object size and timing) that are available whenever a client uploads a file to a curious cloud provider.
Fixed point error analysis of CORDIC processor based on the variance propagation (2003)

The effects of angle approximation and founding in the CORDIC processor have been intensively studied for the determination of design parameters. However, the conventional analyses provide only the error bound which results in large discrepancy between the analysis and the actual implementation. Moreover, some of the signal processing architectures require the specification in terms of the mean squared error (MSE) as in the design specification of FFT processor for OFDM. This paper proposes a fixed point MSE analysis based on the variance propagation for more accurate error expression of CORDIC processor. It is shown that the proposed analysis can also be applied to the modified CORDIC algorithms. As an example of application, an FFT processor for OFDM using the CORDIC processor is presented. The results show close match between the analysis and simulation.