gebhart/patrepeval huggingface dataset:
Panobinostat induces cell death through Endoplasmic Reticulum stress in hepatocellular cancer cells (2010)

Aims: Panobinostat (LBH589), a pan-deacetylase inhibitor, represents a novel therapeutic option for human cancer diseases. We have previously shown that panobinostat has a potent apoptotic activity in vitro and causes a significant growth delay of hepatocellular carcinoma (HCC) tumor xenografts in nude mice models. We have demonstrated that treatment with panobinostat is able to induce cell death in HepG2 (p53wt) and in Hep3B (p53null) cell lines that, interestingly, is not dependent on canonical apoptotic pathways. Here we analyse the involvement of Endoplasmic Reticulum (ER) in cell death induced by panobinostat treatment.
Regression, ARIMA and ARIMAX Models to Study the Factors affecting Foreign Direct Investment in India (2015)

The paper describes Regression, ARIMA and ARIMAX analyses on GDP, inflation, exchange rate, export, import, energy generation and trade balance to estimate the foreign direct investment (FDI) in India. Specifically, we compared the results achieved from the fitted models viz., ARIMA and ARIMA with explanatory variable(s). The main emphasis was to see whether the ARIMA model including other time series as input variables helps in improving the forecasting performance. For this empirical study, we found that ARIMA(1, 1, 0) model with GDP as explanatory variable outperformed the Regression/ARIMA models for estimating the value of FDI in india.
Improving the cross regulation of multi-output SRC by adding the magnetic fence and capacitance compensation (2015)

In this paper, a novel method for improving the cross regulation characteristics in multi-output series resonant converter (SRC) is proposed. The proposed method is based on the theory of eddy demagnetization and series resonant. The proposed method is verified on a single input with four outputs SRC, the input of SRC is 12V with 24V in every output. Both the experimental results and FEM simulation are presented to demonstrate the theoretical analysis. The experimental results illustrate that the proposed method can improve the cross regulation characteristics in multi-output SRC, and make the outputs of multi-output SRC stable.
Prospective randomized study on the use of a computer‐based endoscopic simulator for training in esophagogastroduodenoscopy (2008)

The performance of endoscopy was improved by 5 h of simulator training. The simulator was more effective with regard to the items related to manipulation skills. Computer-based simulator training in EGD is useful for beginners.
Increasing the International competitiveness of exports from Caribbean countries (1991)

This summary report attempts to capture the main points of view presented both in the background papers and from the floor of the Economic Development Institute (EDI) seminar held in Barbados. The four main sections conform with the following themes: (a) the definition of a conceptual framework for measuring and monitoring the degree of export competitiveness; (b) the main elements of an economic package necessary to achieve improved export competitiveness; (c) the experience of successful exporters, drawing on two background papers - one in the experience of East Asia, and the second, on the export performance of Mauritius; and (d) regional arrangements to stimulate improved export performance, especially the role of the Caribbean Community.
Discotic liquid crystals Physical parameters of some 2,3,7,8,12,13-hexa(alkanoyloxy)truxenes. Observation of a re-entrant isotropic phase in a pure disc-like mesogen (1988)

\n Contains fulltext :\n 10647.pdf (Publisher’s version ) (Open Access)\n
IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation (2022)

Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases. To better understand how IL-6 signaling may influence human T cell fate, we investigated the relationships between levels of components of the IL-6R complex, pSTAT responses, and transcriptomic and translational changes in CD4<sup>+</sup> and CD8<sup>+</sup> T cell subsets from healthy individuals after exposure to IL-6. Our findings highlight the striking heterogeneity in mbIL-6R and gp130 expression and IL-6-driven pSTAT1/3 responses across T cell subsets. Increased mbIL-6R expression correlated with enhanced signaling <i>via</i> pSTAT1 with less impact on pSTAT3, most strikingly in CD4<sup>+</sup> naïve T cells. Additionally, IL-6 rapidly induced expression of transcription factors and surface receptors expressed by T follicular helper cells and altered expression of markers of apoptosis. Importantly, many of the features associated with the level of mbIL-6R expression on T cells were recapitulated both in the setting of tocilizumab therapy and when comparing donor CD4<sup>+</sup> T cells harboring the genetic variant, <i>IL6R</i> Asp358Ala (rs2228145), known to alter mbIL-6R expression on T cells. Collectively, these findings should be taken into account as we consider the role of IL-6 in disease pathogenesis and translating IL-6 biology into effective therapies for T cell-mediated autoimmune disease.
Overview on Development of Remote Teaching Laboratories: from LabVIEW to Web Services (2006)

For last years, a large number of universities have been focusing their attention on the opportunity of making students capable to observe experimental activities, from their home and at any time, through Internet. The realization of remote laboratories for engineering disciplines, in particular for a measurement course, presents further problems, since it is required that students interact with remote circuit and handle measurement instruments. The crucial task is, hence, to implement Web/Internet-enabled applications that can be fully controlled and monitored from remote locations. There is a wide variety of solutions enabling the remote control of measurement instrumentation; each one is characterized by its peculiarities, advantages, and drawbacks. In the paper an overview on the most adopted technologies is performed. Particular attention is paid on Web services technology that proves to be a general solution, suitable for each type of application
Histologic and Ultrastructural Characterization of Corneal Femtosecond Laser Trephination (2009)

Corneal trephination performed by the femtosecond laser preserves the ultrastructure of the disrupted collagen fibers. In edematous corneas, a layer of cellular and collagenic debris thicker in the anterior stroma and thinner in the posterior stroma runs along the edges of the incision obtained at a constant laser energy density.
3,3'-Dinitrobenzophenone as a cathode material in a magnesium/zinc based primary battery (2000)

The efficiency of 3,3'-dinitrobenzophenone as a cathode material in a magnesium/zinc based primary battery is examined. The discharge performance of the cell is investigated under different parametric variations such as temperature, nature of electrolyte, current drain and zeolite modification . A 14e reduction seems to be responsible for the electrochemical reaction causing the red uction of 3,3'-dinitrobenzophenone to the diamino derivative, including the reduction of carbony l group.
Pro-inflammatory effects ofBurkholderia cepaciaon cystic fibrosis respiratory epithelium (2003)

Burkholderia cepacia causes pulmonary infection with high mortality in cystic fibrosis (CF) patients which is likely to involve interaction with respiratory epithelium. In this study the pro-inflammatory properties of B. cepacia were examined using a range of respiratory epithelial cell lines. B. cepacia and cell-free culture supernatants were used to stimulate cell lines with (SigmaCFTE29o- and IB3) and without (A549) the CF transmembrane conductance regulator mutation (CFTR), together with corrected cell lines (C38 and S9). Interleukin (IL)-6 and IL-8, but not GM-CSF or IL-1beta, were released from all the cell lines whereas PGE(2) (prostaglandin E(2)) was released from the A549, IB3 and S9 cell lines only. Nuclear factor (NF)-kappaB activation preceded cytokine release and suppression of NF-kappaB activity diminished cytokine release. These studies indicated that B. cepacia secretory products are potent pro-inflammatory agents for respiratory epithelium and suggest functional CFTR is not required for cytokine or prostanoid responses.
On Progresses and Inspiration of Oil Painting since China's Reform:Influence of Social Form on Composition of Oil Painting (2011)

Chinese oil painting in content and presentation are subject to the effects of social form,especially political and economic influence since reform and opening.The painting of the first phase is dominated by the effect of political and policy factors;the second is influenced by political and economic ones in common;the third is majored by the economic elements.The economy could be the main factors affecting the creation of oil painting in China for a certain time in the future.
Direct Sulfide-Catalyzed Enantioselective Cyclopropanations of Electron-Deficient Dienes and Bromides (2018)

A catalytic highly regioselective, diastereoselective, and enantioselective cyclopropanation of electron-deficient dienes and bromides via direct sulfide organocatalysis is reported. A variety of vinylcyclopropanes featuring a quaternary chiral center were synthesized in up to 99% yield and up to 98:2 enantiomeric ratio (er). These products could be facilely transformed to various interesting molecules with great structural diversity.
A Simple Synchronous Distributed-Memory Algorithm for the HPCC RandomAccess Benchmark. (2016)

Abstract not provided.
Optimizing the Balance Between Radiation Dose and Image Quality in Pediatric Head CT: Findings Before and After Intensive Radiologic Staff Training (2014)

Radiologic staff training can be effective in reducing radiation dose while preserving diagnostic image quality in pediatric head CT examinations.
Standardized Surgical Video Curriculum for Teaching Residents Principles of Abdominal Hysterectomy (2021)

A video module can be a high-quality and effective educational tool for teaching the surgical principles, anatomy, and steps to perform abdominal hysterectomy to obstetrics and gynecology residents.
Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis (2009)

Dysfunction and loss of insulin-producing pancreatic beta cells represent hallmarks of diabetes mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38delta display improved glucose tolerance due to enhanced insulin secretion from pancreatic beta cells. Deletion of p38delta results in pronounced activation of protein kinase D (PKD), the latter of which we have identified as a pivotal regulator of stimulated insulin exocytosis. p38delta catalyzes an inhibitory phosphorylation of PKD1, thereby attenuating stimulated insulin secretion. In addition, p38delta null mice are protected against high-fat-feeding-induced insulin resistance and oxidative stress-mediated beta cell failure. Inhibition of PKD1 reverses enhanced insulin secretion from p38delta-deficient islets and glucose tolerance in p38delta null mice as well as their susceptibility to oxidative stress. In conclusion, the p38delta-PKD pathway integrates regulation of the insulin secretory capacity and survival of pancreatic beta cells, pointing to a pivotal role for this pathway in the development of overt diabetes mellitus.
Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells (2012)

Medullary thyroid cancer (MTC) is associated with activation of mammalian target of rapamycin (mTOR) signaling pathways. Recent studies showed that the antidiabetic agent metformin decreases proliferation of cancer cells through 5'-AMP-activated protein kinase (AMPK)-dependent inhibition of mTOR. In the current study, we assessed the effect of metformin on MTC cells. For this purpose, we determined growth, viability, migration, and resistance to anoikis assays using two MTC-derived cell lines (TT and MZ-CRC-1). Expressions of molecular targets of metformin were examined in MTC cell lines and in 14 human MTC tissue samples. We found that metformin inhibited growth and decreased expression of cyclin D1 in MTC cells. Treatment with metformin was associated with inhibition of mTOR/p70S6K/pS6 signaling and downregulation of pERK in both TT and MZ-CRC-1 cells. Metformin had no significant effects on pAKT in the cell lines examined. Metformin-inducible AMPK activation was noted only in TT cells. Treatment with AMPK inhibitor (compound C) or AMPK silencing did not prevent growth inhibitory effects of metformin in TT cells. Metformin had no effect on MTC cell migration but reduced the ability of cells to form multicellular spheroids in nonadherent conditions. Immunostaining of human MTC showed over-expression of cyclin D1 in all tumors compared with corresponding normal tissue. Activation of mTOR/p70S6K was detected in 8/14 (57.1%) examined tumors. Together, these findings indicate that growth inhibitory effects in MTC cells are associated with downregulation of both mTOR/6SK and pERK signaling pathways. Expression of metformin's molecular targets in human MTC cells suggests its potential utility for the treatment of MTC in patients.
H134 Time-resolved measurement and characterization of transient lens effect in liquid excited by nanosecond pulse YAG laser (2012)

Laser processing and laser measurement has attracted attention from a vaiety of fields with the recent advances in laser technology. In particular, short pulse laser is useful in microfabrication and high-speed measurement, and further research of transient lens effect is expected. We have proposed a temporal and spatial pulse shaping technique with an effective refractive index change due to ransient lens effect. However, sub-nanosecond time scale change in refractive index of the transient lens effect has not been clear. In this study, we have established a method of time-resolved measurement of the refractive index change caused by the transient lens effect and measured tub-nanosecond time scale change in refractive index of the transient lens effect.
Reduction in Hospital System Opioid Prescribing for Acute Pain Through Default Prescription Preference Settings: Pre–Post Study (Preprint) (2020)

<sec> <title>BACKGROUND</title> The United States is in an opioid epidemic. Passive decision support in the electronic health record (EHR) through opioid prescription presets may aid in curbing opioid dependence. </sec> <sec> <title>OBJECTIVE</title> The objective of this study is to determine whether modification of opioid prescribing presets in the EHR could change prescribing patterns for an entire hospital system. </sec> <sec> <title>METHODS</title> We performed a quasi-experimental retrospective pre–post analysis of a 24-month period before and after modifications to our EHR’s opioid prescription presets to match Centers for Disease Control and Prevention guidelines. We included all opioid prescriptions prescribed at our institution for nonchronic pain. Our modifications to the EHR include (1) making duration of treatment for an opioid prescription mandatory, (2) adding a quick button for 3 days’ duration while removing others, and (3) setting the default quantity of all oral opioid formulations to 10 tablets. We examined the quantity in tablets, duration in days, and proportion of prescriptions greater than 90 morphine milligram equivalents/day for our hospital system, and compared these values before and after our intervention for effect. </sec> <sec> <title>RESULTS</title> There were 78,246 prescriptions included in our study written on 30,975 unique patients. There was a significant reduction for all opioid prescriptions pre versus post in (1) the overall median quantity of tablets dispensed (54 [IQR 40-120] vs 42 [IQR 18-90]; &lt;i&gt;P&lt;/i&gt;&amp;lt;.001), (2) median duration of treatment (10.5 days [IQR 5.0-30] vs 7.5 days [IQR 3.0-30]; &lt;i&gt;P&lt;/i&gt;&amp;lt;.001), and (3) proportion of prescriptions greater than 90 morphine milligram equivalents/day (27.46% [10,704/38,976; 95% CI 27.02%-27.91%] vs 22.86% [8979/39,270; 95% CI 22.45%-23.28%]; &lt;i&gt;P&lt;/i&gt;&amp;lt;.001). </sec> <sec> <title>CONCLUSIONS</title> Modifications of opioid prescribing presets in the EHR can improve prescribing practice patterns. Reducing duration and quantity of opioid prescriptions could reduce the risk of dependence and overdose. </sec>
Pressure-driven spreadable deferoxamine-laden hydrogels for vascularized skin flaps (2021)

The development of hydrogels that support vascularization to improve the survival of skin flaps, yet establishing homogeneous angiogenic niches without compromising the ease of use in surgical settings remains a challenge. Here, pressure-driven spreadable hydrogels were developed utilizing beta-sheet rich silk nanofiber materials. These silk nanofiber-based hydrogels exhibited excellent spreading under mild pressure to form a thin coating to cover all the regions of the skin flaps. Deferoxamine (DFO) was loaded onto the silk nanofibers to support vascularization and these DFO-laden hydrogels were implanted under skin flaps in rats to fill the interface between the wound bed and the flap using the applied pressure. The thickness of the spread hydrogels was below 200 μm, minimizing the physical barrier effects from the hydrogels. The distribution of the hydrogels provided homogeneous angiogenic stimulation, accelerating rapid blood vessel network formation and significantly improving the survival of the skin flaps. The hydrogels also modulated the immune reactions, further facilitating the regeneration of the skin flaps. Considering the homogeneous distribution at the wound sites, improved vascularization, reduced barrier effects and low inflammation, these hydrogels appear to be promising candidates for use in tissue repair where a high blood supply is in demand. The pressure-driven spreading properties should simplify the use of the hydrogels in surgical settings to facilitate clinical translation.
Lexical semantics to disambiguate polysemous phenomena of Japanese adnominal constitutents (1999)

We exploit and extend the Generative Lexicon Theory to develop a formal description of adnominal constituents in a lexicon which can deal with linguistic phenomena found in Japanese adnominal constituents. We classify the problematic behavior into "static disambiguation" and "dynamic disambiguation" tasks. Static disambiguation can be done using lexical information in a dictionary, whereas dynamic disambiguation requires inferences at the knowledge representation level.
PRODUCTION OF THE ANTITUMOR L-GLUTAMINASE ENZYME FROM THERMOTOLERANT Streptomyces sp. D214, UNDER SUBMERGED FERMENTATION CONDITIONS (2017)

L-glutaminase is an amidohydrolase which produced by a variety of microorganisms including bacteria, yeast and fungi. In recent years, it widely used as an anticancer drug and as flavor enhancing agent. This study was aimed to production of extracellular L-glutaminase from bacteria. About 20 soil samples were collected and out of 40 pure bacterial cultures, the isolate RK9 was the most active in L-glutaminase production in solid and broth media containing L-glutamine as the carbon and nitrogen sources. Lglutaminase producing isolate was identified as Streptomyces sp. D214 by using morphological, physiological and molecular characters. Further, it was reported that maximum enzyme production occurred by using minimal medium containing L-glutamine at pH7 and incubation temperature 45C after 5 days of growth at 120 rpm. Addition of 3% NaCl enhanced enzyme production. The enzyme was collected and purified by using column chromatography. The purified enzyme showed excellent antitumor activity against the tumor cell line MCF-7 with IC50 of 10g/ml. In conclusion, saline soil is a good source of bacteria especially genus Streptomyces that produce salt tolerant L-glutaminase, the antitumor agent with more activity and less toxicity.
Generation of extreme ultraviolet vector beams from infrared laser pulses (2017)

Vector beams are light beams with spatially variant polarization [1]. During the last decade vector beams have become an indispensable tool in many areas of science and technology such as optical trapping, quantum memories, and quantum optics. In particular, radially and azimuthally polarized light beams are the paradigm of vector beams. Radial vector beams are especially interesting due to the non-vanishing longitudinal electric field component present in tightly focusing systems, which allows to sharply focus light below the diffraction limit [2]. On the other hand, azimuthal vector beams can induce longitudinal magnetic fields with potential applications in spectroscopy and microscopy. However, the spectral limitations of the generation techniques of vector beams based on linear optics prevent their efficient generation in the extreme-ultraviolet (EUV) and x-ray regimes, which would further extend their applications down to the nanometric scale. High-order harmonic generation (HHG) is known as a unique non-perturbative frequency up-conversion process for the generation of coherent EUV and soft x-ray radiation. A remarkable aspect of HHG is its fully coherent nature, mapping the characteristics of the driving field to the high frequency spectral region and thus allowing to harness the angular momentum properties of the harmonic radiation through modifications of the driving field [3-5].
Comparison of Revalor XS to a Revalor IS / Revalor S Implant Strategy in Finishing Steers (2010)

A commercial feedlot study compared effects of Revalor IS/Revalor S (RevIS-S) implant strategy to a Revalor XS (RevX) single implant strategy on performance and carcass characteristics of feedlot cattle. There were no differences (P > 0.90) in DMI, final BW, ADG, or F:G. Hot carcass weight, marbling score, 12th rib fat, LM area and calculated yield grade also were unaffected (P > 0.10) by implant strategy. The RevX treatment resulted in a greater (P < 0.01) percentage of Choice carcasses than RevIS-S. Cattle receiving Revalor XS performed similar to cattle implanted with RevIS-S using a traditional reimplant program.
Antihyperglycemic N-Sulfonyl-1a,2,6,6a-tetrahydro-1H,4H-[1,3]dioxepino[5,6-b]azirines: Synthesis, X-ray Structure Analysis, Conformational Behavior, Quantitative Stroposcopic Pulse Radiolysis, and Quantitative Structure-Activity Relationships (1995)

A series of 1-sulfonyl-1a,2,6,6a-tetrahydro-1H,4H- [1,3]dioxepino[5,6-b]azirines, 4, has been synthesized and evaluated for its effects on blood glucose-decreasing activity. These derivatives were prepared from 4,7-dihydro-1,3-dioxepins 1 via vic(acylamino)halogenodioxepanes 2 and dioxepinoazirines 3. Quantitative structure--property relationship and quantitative structure--activity relationship models, based on X-ray and molecular mechanics analyses, to our knowledge the first in the field of antihyperglycemics, were developed. They allow the prediction of properties (RP-HPLC attention times) and activities (hypoglycemic activity ratio) by the Connolly's molecular surface areas. The lead compound in these models, sulfonyldioxepinoazirine 4i, expressed superior antihyperglycemic activity in comparison to metformin in alloxanized mice, irrespective of route of application. It significantly reduced blood glucose levels in glucose-primed mice, but it did not cause a dose dependent decrease of blood glucose level in healthy (nondiabetic, control) animals.