gebhart/patrepeval huggingface dataset:
Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine (2023)

It is concluded that intracellular adenosine/2'-deoxyadenosine regulates negatively the PI3K pathway and is therefore an important mediator of beta-cell apoptosis. Adenosine levels are controlled, at least in part, by ADA1, and strategies to upregulate ADA1 activity, during conditions of metabolic stress, could be useful in attempts to preserve beta-cell mass in diabetes.
Transient Activation and Tyrosine Phosphorylation of a Protein Kinase in Tobacco Cells Treated with a Fungal Elicitor (1995)

Kaoru Suzuki, Hideaki Shinshi, Transient Activation and Tyrosine Phosphorylation of a Protein Kinase in Tobacco Cells Treated with a Fungal Elicitor, The Plant Cell, Vol. 7, No. 5 (May, 1995), pp. 639-647
Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability (1986)

A solid-phase method using a phosphoramidite approach is described for synthesis of oligoribonucleotides. The method was used to synthesize pairs of oligomers with identical nearest neighbors but different sequences. Comparison of thermodynamic parameters for these pairs provides a test of the nearest-neighbor hypothesis for prediction of helix stability. In general, pairs of sequences with identical nearest neighbors have enthalpy and entropy changes for helix formation that differ by 8% on average, delta Go37 that differ by 6% on average, and melting temperatures within 0-5 degrees C of each other. These limits are typical of the accuracy that should be expected from nearest-neighbor predictions of RNA helix stability. UCAUGA and UGAUCA have the same nearest neighbors but melting temperatures that differ by 7 degrees C. This suggests some sequences will not be approximated well by the nearest-neighbor model.
Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery (2017)

Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for globally important pathogens such as human immunodeficiency virus, malaria, and tuberculosis. Exciting recent advances in immunology and biotechnology over the past few decades have facilitated a shift from empirical to rational vaccine design, opening possibilities for improved vaccines. Some of the most important advancements include (i) the purification of subunit antigens with high safety profiles, (ii) the identification of innate pattern recognition receptors (PRRs) and cognate agonists responsible for inducing immune responses, and (iii) developments in nano- and microparticle fabrication and characterization techniques. Advances in particle engineering now allow highly tunable physicochemical properties of particle-based vaccines, including composition, size, shape, surface characteristics, and degradability. Enhanced collaborative efforts between researchers in immunology and materials science are expected to rise to next-generation vaccines. This process will be significantly aided by a greater understanding of the immunological principles guiding vaccine antigenicity, immunogenicity, and efficacy. With specific emphasis on PRR-targeted adjuvants and particle physicochemical properties, this review aims to provide an overview of the current literature to guide and focus rational particle-based vaccine design efforts.
A Compound Possessing Antitumor and Interferon-Inducing Acticites Derived from the Common Antigen (OEP) of Pseudomonas aeruginosa1 (1978)

OEP, a component consisting mainly of protein with small amounts of lipids and sugars, has been isolated from the autolysate of Pseudomonas aeruginosa and purified by physicochemical methods. It possesses remarkable biological properties, showing antitumor and interferon-inducing activities. As regards the antitumor activity of the sample, the ED50 value against ascites sarcoma-180 was 1 microgram/kg mouse/day, and its interferon-inducing activity amounted to 15 units at a concentration of 0.01 microgram/ml. Both activities increased after protease digestion, reaching about ten times those of the sample which had not undergone digestion. The protease-treated OEP contained 17% protein, 14.5% total sugars, 31% lipids, 12.5% hexosamine, 3.8% KDO, and 2.7% phosphorus. Neutral sugars consisted of 12.4% rhamnose, 2.7% mannose, 66.9% glucose, and other unidentified material. Total lipids derived from OEP consisted of 65% loosely-bound and 35% covalently-bound lipids; the former contained C14:10, C16:0, C16:1, C18:0, and C15:1 acids and the latter, beta-OH C10:0, C12:0, alpha-OH C12:0, beta-OH C12:0, C16:0, and C16:1 acids. The antitumor and interferon-inducing activities of OEP remained after the removal of loosely-bound lipids from OEP.
DESIGN ATTRIBUTES AND PERFORMANCE OUTCOMES: A FRAMEWORK FOR COMPARING BUSINESS PROCESSES (2005)

Though business processes have been a topic of constant attention to the organization in this decade, the term “Business Process” is understood and interpreted by people differently. This difference in understanding and interpretation is presenting difficulties for organizations to learn from business processes of other organizations or functions. Based on existing literature, this study attempts to identify and demonstrate the common design attributes and performance various business processes share. The common design attributes are identified as process context, process sub parts, process interaction and process management. The common performance measures are classified into higher level measures as process efficiency, process effectiveness and process flexibility. These attributes and outcomes can be used to compare various business processes and thus enable learning from one business process to another.
A New Use for a Familiar Fold:  The X-ray Crystal Structure of GTP-Bound GTP Cyclohydrolase III fromMethanocaldococcus jannaschiiReveals a Two Metal Ion Catalytic Mechanism, (2007)

GTP cyclohydrolase (GCH) III from Methanocaldococcus jannaschii, which catalyzes the conversion of GTP to 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (FAPy), has been shown to require Mg2+ for catalytic activity and is activated by monovalent cations such as K+ and ammonium [Graham, D. E., Xu, H., and White, R. H. (2002) Biochemistry 41, 15074-15084]. The reaction is formally identical to that catalyzed by a GCH II ortholog (SCO 6655) from Streptomyces coelicolor; however, SCO 6655, like other GCH II proteins, is a zinc-containing protein. The structure of GCH III complexed with GTP solved at 2 A resolution clearly shows that GCH III adopts a distinct fold that is closely related to the palm domains of phosphodiesterases, such as DNA polymerase I. GCH III is a tetramer of identical subunits; each monomer is composed of an N- and a C-terminal domain that adopt nearly superimposible structures, suggesting that the protein has arisen by gene duplication. Three metal ions were located in the active site, two of which occupy positions that are analogous to those occupied by divalent metal ions in the structures of a number of palm domain containing proteins, such as DNA polymerase I. Two conserved Asp residues that coordinate the metal ions, which are also found in palm domain containing proteins, are observed in GCH III. Site-directed variants (Asp-->Asn) of these residues in GCH III are less active than wild-type. The third metal ion, most likely a potassium ion, is involved in substrate recognition through coordination of O6 of GTP. The arrangement of the metal ions in the active site suggests that GCH III utilizes two metal ion catalysis. The structure of GCH III extends the repertoire of possible reactions with a palm fold to include cyclohydrolase chemistry.
Comment on "Nonplanar VLSI arrays with high fault-tolerance capabilities (1989)

In the above-named work (see ibid., vol.38, p.51-7, April 1989), S. Lafiti and A. El-Amawy apply, in a straightforward manner, the method developed by A.D. Singh (1985) to calculate lower bounds for the yield of nonplanar interstitial redundancy topologies of processor arrays with spare processors. In their introduction, they claim that the models suggested by I. Koren and D.K. Pradhan (1987) are highly theoretical since the number of states in the Markov model might be very large and the determination of the transition rates might be intractable. They add that applying some empirical rules, as suggested by Koren and Pradhan (1987), can lead to unrealistic results and may require a large number of computations. They also claim that the model of Koren and Pradhan does not suggest an algorithm to replace faulty elements. They conclude that a simpler model, like the one proposed by Singh, is needed for calculating the yield of fault-tolerant processor arrays. In the present comment, Koren and Pradhan respond to the above comments and attempt to clarify the differences between their yield analysis and that of Singh.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cardiac Gene Delivery With Cardiopulmonary Bypass (2001)

By using cardiopulmonary bypass and cardioplegic arrest, intracoronary delivery of adenoviral vectors resulted in efficient myocardial uptake and expression. Undetectable transgene expression in liver or lung tissue suggests cardiac-selective expression.
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature (2012)

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is implicated in the etiology of metabolic syndrome. We previously showed that pharmacological inhibition of 11β-HSD1 ameliorated multiple facets of metabolic syndrome and attenuated atherosclerosis in ApoE-/- mice. However, the molecular mechanism underlying the atheroprotective effect was not clear. In this study, we tested whether and how 11β-HSD1 inhibition affects vascular inflammation, a major culprit for atherosclerosis and its associated complications. ApoE-/- mice were treated with an 11β-HSD1 inhibitor for various periods of time. Plasma lipids and aortic cholesterol accumulation were quantified. Several microarray studies were carried out to examine the effect of 11β-HSD1 inhibition on gene expression in atherosclerotic tissues. Our data suggest 11β-HSD1 inhibition can directly modulate atherosclerotic plaques and attenuate atherosclerosis independently of lipid lowering effects. We identified immune response genes as the category of mRNA most significantly suppressed by 11β-HSD1 inhibition. This anti-inflammatory effect was further confirmed in plaque macrophages and smooth muscle cells procured by laser capture microdissection. These findings in the vascular wall were corroborated by reduction in circulating MCP1 levels after 11β-HSD1 inhibition. Taken together, our data suggest 11β-HSD1 inhibition regulates proinflammatory gene expression in atherosclerotic tissues of ApoE-/- mice, and this effect may contribute to the attenuation of atherosclerosis in these animals.
Transesophageal Echocardiogram-Guided Stent Placement in Superior Vena Cava Syndrome Secondary to Granulomatous Lung Disease: A Case Series and Literature Review (2017)

Obstruction of the superior vena cava (SVC) is an uncommon, but potentially life-threatening condition due to likely development of edema in the head and neck and potential respiratory compromise. Less than half of those affected by SVC syndrome survive more than a year. Obstruction can be from neoplasms or secondary to benign disease. Treatment for most cases of symptomatic SVC syndrome involves placement of a stent to relieve the stenosis. Serious complications such as stent migration, pulmonary embolism, and cardiac tamponade can occur in 5% to 10% of cases, and inadequate imaging of the SVC-atrial junction by fluoroscopy contributes to these problems. The overlapping contrast in the atrium makes it difficult to precisely place the distal end of the stent, potentially allowing for embolization of the stent to occur. We present a case series of 3 patients wherein transesophageal echocardiography was used for guidance of stent placement in the SVC and significantly aided in placement.
Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging (2013)

The radiosynthesis of glucosamine and similar analogues would be of great interest due to their role in the biochemical synthesis of glycosylated proteins and lipids. This biochemistry can be exploited for visualisation of cancer cells via molecular imaging. This report details the synthesis of a number of 18F-labelled glucosamine derivatives and evaluation of their tumour uptake and normal tissue distribution in vivo in a mouse model of cancer by positron emission tomography (PET) imaging.
Solar energy research at LASL. Progress report, October 1, 1977-March 31, 1978 (1979)

This report documents the work of the Solar Energy Group, Q-11, of the Los Alamos Scientific Laboratory from October 1977 through March 1978. We provided scientific and technical support to DOE, performed research on solar collectors, and carried out studies and evaluations of both passive and active solar heating systems. The Group's work also included vigorous information dissemination activities.
FABRICATION TECHNOLOGY OF PIEZORESISTIVE CONDUCTIVE PDMS F FOR R M MI ICR RO FING GE ER RPRI INT T SENS SO OR RS S (2007)

This paper reports the characterization of piezoresistivity of Conductive Polydimethylsiloxane (CPDMS) and the corresponding fabricating process for a parylene-coated, CPDMS Micro Fingerprint Sensor (MFS) with mushroomshaped electrodes. Gauge factor of about 7.4 was demonstrated, and the piezoresistive sensitivity was about 3×10 -6 Pa -1 in the tensile test setup. The packaged MFS sensors were characterized by a pneumatic test and a nanoindentation test. We demonstrate that the fabricated device can detect pressure and force levels bellow 10 kPa and 50 µN, respectively. The use of the material and process presented in this paper offers the opportunity to realize a robust micro fingerprint sensor with low cost, low temperature process on different substrates.
Exploiting common subqueries for complex query optimization (2024)

As database technology is applied to more and more application areas, user queries on a database become more and more complex. Existing query optimization techniques were not developed for dealing with complex queries and may suffer from some serious problem such as intolerably long optimization time and poor optimizing results. To tackle this challenge, we introduce a new technique to improve the quality of complex query optimization in this paper. The key idea is to exploit the common subqueries that often appear in a complex query and reuse the optimization work done for each common subquery. An algorithm to identify common subqueries efficiently and generate a high-quality execution plan for a given complex query is proposed. The complexity of the algorithm is analyzed. Experiments demonstrate that this proposed polynomial-time technique is quite promising in optimizing complex queries for a database management system.
Reactivity with alkali carbonates of a newly developed oxide ionic conductor, Nd9.83(SiO4)4.5(AlO4)1.5O2 with apatite-type structure (2009)

The reactivity of a newly developed oxygen ionic conductor, Nd9.83(SiO4)4.5(AlO4)1.5O2, with alkali carbonates was examined in air and CO2. The reactivity of the developed ionic conductor was substantially lower than that of ZrO2, 3YSZ and 8YSZ in air and also in CO2. It is concluded that this newly developed oxide is more tolerant to the alkali contamination and is applicable as a potentiometric oxygen concentration gas sensor.
Coding capacity of complementary DNA strands (1981)

A Fortran computer algorithm has been used to analyze the nucleotide sequence of several structural genes. The analysis performed on both coding and complementary DNA strands shows that whereas open reading frames shorter than 100 codons are randomly distributed on both DNA strands, open reading frames longer than 100 codons ("virtual genes") are significantly more frequent on the complementary DNA strand than on the coding one. These "virtual genes" were further investigated by looking at intron sequences, splicing points, signal sequences and by analyzing gene mutations. On the basis of this analysis coding and complementary DNA strands of several eukaryotic structural genes cannot be distinguished. In particular we suggest that the complementary DNA strand of the human epsilon-globin gene might indeed code for a protein.
Electrochemical Comparison and Deposition of Lithium and Potassium from Phosphonium- and Ammonium-TFSI Ionic Liquids (2009)

Two room-temperature ionic liquids, [(trifluoromethanesulfonyl)imide] and , were synthesized and their electrochemical behavior was investigated using CV. The phosphonium-based ionic liquid (IL) showed improved stability and physical properties compared to the analogous ammonium-based IL. The phosphonium-based IL had higher conductivity than the ammonium-based IL . The lower viscosity and higher stability of the phosphonium-based IL led to higher current density and stability for electrodeposited lithium metal. The addition of LiTFSI to both ILs led to a decrease in conductivity and increase in viscosity. An optimum deposition potential was found that was bounded by the electrochemical stability of each IL. The stability of lithium in the ILs increased at lower temperature due to slower reactivity with the IL. The electrodeposition and reoxidation of potassium was also demonstrated. It was found that a lithium-potassium alloy could be deposited at high current for long times without the occurrence of dendrites.
Mixed lumped and distributed network applied to superconducting thin-film broadband impedance transforming (2002)

A detailed analysis of the properties of a mixed lumped and distributed (MLD) lossless network is carried out showing why the MLD network can be used as an extreme impedance transformer between source and load impedances without using extreme impedance values in the network. Then, the lossy transformation technique, which can be employed for the transformation between an MLD lossy or lossless network and a lumped lossless one, is discussed and compared with Carlin's method. Finally, as an example, one quarter-wave and two MLD lossless broadband impedance transformers are synthesized for transforming the extremely low input or output impedance of a superconducting device to a 50 Omega microwave system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
V6-04 FULL IMMERSION SIMULATED PERCUTANEOUS NEPHROLITHOTOMY USING 3D PRINTING TECHNOLOGY (2016)

flexible nephroscope. The technique requires pressure irrigation to 300mmHg and an Amplatz sheath to allow free egress of the fragments. J-wire is particularly useful for calyces that are difficult to reach with the rigid nephroscope and allows for quick and atraumatic removal of small fragments. J-wire also allows relocation of stone fragments to a position that can be easily reached with a rigid nephroscope and lithotriptor.
Cardiac Glycosides Inhibit LPS-induced Activation of Pro-inflammatory Cytokines in Whole Blood through an NF-kB-dependent Mechanism (2011)

Summary: The process of hemodialysis (HD) produces a pro-inflammatory state that can lead to an increased risk for cardiovascular disease. In part, this is the result of activation of the pro-inflammatory transcription factor NF-kB in response to uremia as well as in response to HD itself, which not only involves exposure of blood leukocytes to abnormal surfaces but also potentially to any bacterial contamination associated with HD. Previously, we used lipopolysaccharide (LPS) to activate isolated peripheral blood mononuclear cells (PBMC), as a model of HD-induced stress, and demonstrated that specific natural products that are known to inhibit the activation of NF-kB exhibited a broad anti-inflammatory activity.  These natural products, however, were not effective when whole blood was used. In the present study, a natural product library (TimTec NPL480) was screened, using whole blood, for the abilities of these natural products to protect against LPS-induced expression and secretion of the pro-inflammatory cytokines TNFa, IL-1b and IL-6.  We report here that the cardiac glycosides strophanthidin, ouabain, proscillaridin A, digoxin, digitoxin and lanatoside C are effective natural products that limit the development of a pro-inflammatory state by preventing the activation of these pro-inflammatory signals. These active natural products also inhibited the stress-induced activation of NF-kB in a reporter assay, suggesting that inhibition of NF-kB is at least partly the mechanism by which these natural products protect whole blood leukocytes from activation by LPS. Industrial relevance: Media for hemodialysis is used millions of times annually for patients with end stage renal disease, each use representing a potential pro-inflammatory insult. It would be useful to have a drug that could be added to the media which would protect blood leukocytes from any pro-inflammatory activation that may accompany the dialysis procedure. A natural product, if demonstrated to have low toxicity, could be especially attractive as a drug candidate for this application.
Motion Artifact Reduction in Quantitative Susceptibility Mapping using Deep Neural Network (2021)

An approach to reduce motion artifacts in Quantitative Susceptibility Mapping using deep learning is proposed. We use an affine motion model with randomly created motion profiles to simulate motion-corrupted QSM images. The simulated QSM image is paired with its motion-free reference to train a neural network using supervised learning. The trained network is tested on unseen simulated motion-corrupted QSM images, in healthy volunteers and in Parkinson's disease patients. The results show that motion artifacts, such as ringing and ghosting, were successfully suppressed.
Oxygen atom transfer in low-temperature matrixes. 1. Formation and characterization of matrix-isolated OMF3 (M = P, As) (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygen atom transfer in low-temperature matrixes. 1. Formation and characterization of matrix-isolated OMF3 (M = P, As)Anthony J. Downs, Geoffrey P. Gaskill, and Simon B. SavilleCite this: Inorg. Chem. 1982, 21, 9, 3385–3393Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/ic00139a023https://doi.org/10.1021/ic00139a023research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts