gebhart/patrepeval huggingface dataset:
Differentially Expressed Proteins in ER+MCF7 and ER-MDA-MB-231 Human Breast Cancer Cells by RhoGDI-α Silencing and Overexpression (2014)

Future studies are needed to determine the mechanisms by which these proteins regulate cell migration. The combination of RhoGDIα with other potential biomarkers may be a more promising approach in the inhibition of breast cancer cell migration.
SHORT COMMUNICATION: EFFECT OF KAPPAPHYCUS ALVAREZII (DOTY) DOTY EX SILVA. EXTRACT ON GRAIN QUALITY, YIELD AND SOME YIELD COMPONENTS OF WHEAT (TRITICUM AESTIVUM L.) (2009)

A pot experiment was conducted in rabi season 2004-05 to study the effect of Kappaphycus alvarezii extract applied as a foliar spray at 0.25%, 0.50% and 1.0% on wheat. Compared to control the yield of grain increased by 80.44% when, the plants were sprayed with 1.0% K. alvarezii extract. The nutritional quality of grain such as carbohydrate, protein and minerals also improved under the influence of treatment.
Nutritional supplements, foods, and epilepsy: Is there a relationship? (2008)

Anecdotal reports suggest that certain foods and dietary contents might influence the occurrence of seizures. However, the existing data are scanty and sometimes controversial. Some studies have found that the supplementation with individual nutrients reduced seizure frequency or improved other aspects of health in patients with epilepsy, while other studies have failed to confirm those findings. Nutrient supplementation may be necessary to prevent or reverse the effects of certain deficiencies that frequently result from the use of antiepileptic drugs (AEDs). However, the potential benefits of nutrient supplementation in patients with epilepsy must be weighed against reports that large doses of certain nutrients can interfere with the action of some AEDs. This paper reviews dietary and nutritional considerations in patients with epilepsy and also the relationship between foods, dietary elements, and seizures.
Synthesis and the Initiator Activity of Fluorenyltriphenylphosphonium Salts in the Cationic Polymerization of Epoxide. Novel Thermally Latent Initiators (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis and the Initiator Activity of Fluorenyltriphenylphosphonium Salts in the Cationic Polymerization of Epoxide. Novel Thermally Latent InitiatorsTatsuya Toneri, Ken-ichi Watanabe, Fumio Sanda, and Takeshi EndoView Author Information Research Laboratory of Resources Utilization, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan Cite this: Macromolecules 1999, 32, 4, 1293–1296Publication Date (Web):February 3, 1999Publication History Received11 August 1998Revised25 November 1998Published online3 February 1999Published inissue 1 February 1999https://doi.org/10.1021/ma981275qCopyright © 1999 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views300Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (154 KB) Get e-AlertsSUBJECTS:Acidity,Cations,Order,Polymerization,Salts Get e-Alerts
Direct Assembly of Hydrophobic Nanoparticles to Multifunctional Structures (2011)

We present a general process that allows convenient production of multifunctional composite particles by direct self-assembly of hydrophobic nanoparticles on host nanostructures containing high-density surface thiol groups. Hydrophobic nanoparticles of various compositions and combinations can be directly assembled onto the host surface through the strong coordination interactions between metal cations and thiol groups. The resulting structures can be further conveniently overcoated with a layer of normal silica to stabilize the assemblies and render them highly dispersible in water for biomedical applications. As the entire fabrication process does not involve complicated surface modification procedures, the hydrophobic ligands on the nanoparticles are not disturbed significantly so that they retain their original properties such as highly efficient luminescence. Many complex composite nanostructures with tailored functions can be efficiently produced by using this versatile approach. For example, multifunctional nonspherical nanostructures can be efficiently produced by using mercapto-silica coated nano-objects of arbitrary shapes as hosts for immobilizing functional nanoparticles. Multilayer structures can also be achieved by repeating the mercapto-silica coating and nanoparticle immobilization processes. Such assembly approach will provide the research community a highly versatile, configurable, scalable, and reproducible process for the preparation of various multifunctional structures.
The effect of testosterone on human T cells in health and autoimmune liver disease (2023)

Females are more prone to develop autoimmune diseases, including primary biliary cholangitis (PBC). The mechanisms underlying this dichotomy are still unknown.
Absorbing Layers and Non-Reflecting Boundary Conditions for Wave Propagation Problems (2005)

The presence of wave motion is the defining feature in many fields of application,such as electro-magnetics, seismics, acoustics, aerodynamics,oceanography and optics. In these fields, accurate numerical simulation of wave phenomena is important for the enhanced understanding of basic phenomenon, but also in design and development of various engineering applications. In general, numerical simulations must be confined to truncated domains, much smaller than the physical space were the wave phenomena takes place. To truncate the physical space, artificial boundaries, and corresponding boundary conditions, are introduced. There are four main classes of methods that can be used to truncate problems on unbounded or large domains: boundary integral methods, infinite element methods, non-reflecting boundary condition methods and absorbing layer methods. In this thesis, we consider different aspects of non-reflecting boundary conditions and absorbing layers. In paper I, we construct discretely non-reflecting boundary conditions for a high order centered finite difference scheme. This is done by separating the numerical solution into spurious and physical waves, using the discrete dispersion relation. In paper II-IV, we focus on the perfectly matched layer method, which is a particular absorbing layer method. An open issue is whether stable perfectly matched layers can be constructed for a general hyperbolic system. In paper II, we present a stable perfectly matched layer formulation for 2 x 2 symmetric hyperbolic systems in (2 + 1) dimensions. We also show how to choose the layer parameters as functions of the coefficient matrices to guarantee stability. In paper III, we construct a new perfectly matched layer for the simulation of elastic waves in an anisotropic media. We present theoretical and numerical results, showing that the stability properties of the present layer are better than previously suggested layers. In paper IV, we develop general tools for constructing PMLs for first order hyperbolic systems. We present a model with many parameters which is applicable to all hyperbolic systems, and which we prove is well-posed and perfectly matched. We also use an automatic method, derived in paper V, for analyzing the stability of the model and establishing energy inequalities. We illustrate our techniques with applications to Maxwell s equations, the linearized Euler equations, as well as arbitrary 2 x 2 systems in (2 + 1) dimensions. In paper V, we use the method of Sturm sequences for bounding the real parts of roots of polynomials, to construct an automatic method for checking Petrowsky well-posedness of a general Cauchy problem. We prove that this method can be adapted to automatically symmetrize any well-posed problem, producing an energy estimate involving only local quantities.
Revenue-Maximizing Rankings for Online Platforms with Quality-Sensitive Consumers (2017)

When a keyword-based search query is received by a search engine, a classified ads website, or an online retailer site, the platform has exponentially many choices in how to sort the search results. Two extreme rules are (a) to use a ranking based on estimated relevance only, which improves customer experience in the long run because of perceived quality and (b) to use a ranking based only on the expected revenue to be generated immediately, which maximizes short-term revenue. Typically, these two objectives and the corresponding rankings differ. A key question then is what middle ground between them should be chosen. We introduce stochastic models that yield elegant solutions for this situation, and we propose effective solution methods to compute a ranking strategy that optimizes long-term revenues. This strategy has a very simple form and is easy to implement if the necessary data is available. It consists of ordering the output items by decreasing order of a score attributed to each, similarly to value models used in practice by e-commerce platforms. This score results from evaluating a simple function of the estimated relevance, the expected revenue of the link, and a real-valued parameter. We find the latter via simulation-based optimization, and its optimal value is related to the endogeneity of user activity in the platform as a function of the relevance offered to them.
Robust & Asymptotically Locally Optimal UAV-Trajectory Generation Based on Spline Subdivision (2020)

Generating locally optimal UAV-trajectories is challenging due to the non-convex constraints of collision avoidance and actuation limits. We present the first local, optimization-based UAV-trajectory generator that simultaneously guarantees the validity and asymptotic optimality for known environments. \textit{Validity:} Given a feasible initial guess, our algorithm guarantees the satisfaction of all constraints throughout the process of optimization. \textit{Asymptotic Optimality:} We use an asymptotic exact piecewise approximation of the trajectory with an automatically adjustable resolution of its discretization. The trajectory converges under refinement to the first-order stationary point of the exact non-convex programming problem. Our method has additional practical advantages including joint optimality in terms of trajectory and time-allocation, and robustness to challenging environments as demonstrated in our experiments.
microRNAs calibrate T cell responses by regulating mTOR (2015)

International audience
Lower conjunctival fornix packing for mydriasis in premature infants: a randomized trial (2012)

The dilated pupil diameter after receiving the lower conjunctival fornix packing was larger than conventional instillation with a statistically significant difference. We recommended the packing method to dilate the preterm infant pupil, especially if the pupil is difficult to dilate.
Spurious structures created by interpolation-based CT metal artifact reduction (2009)

Under normal circumstances the quality of images reconstructed with the classic FBP CT reconstruction algorithm is adequate for medical diagnosis. However, in some special cases the assumptions made by this method are not applicable because of non-linearities in the underlying physical imaging processes. Especially in the presence of metal implants in the field of view, effects like beam hardening, scatter and photon starvation result in serious streaking and banding artifacts around and between these objects. In order to reduce the artifacts, several different types of correction methods were introduced during the last two decades. In one of the most often used approaches, an interpolation scheme is used to replace all corrupted beam data in the shadow of the metal with artificially generated values. Although this leads to a reduction of the most severe artifacts, typically the results are far from being perfect. Instead of removing all artifacts, in most cases new streak artifacts are introduced. In the present work it is shown that the origin of these new artifacts is related to the loss of edge information of the objects by using surrogate data. The application of a more sophisticated artifact reduction method based on a segmentation of a preliminary reconstructed image decreases the number of newly introduced artifacts to a large degree. This is possible, because edge information between air and tissue recovered from the preliminary reconstruction can be included into the correction scheme. It is concluded that a restoration scheme without additionally information is not sufficient for a successful metal artifact reduction method.
Development of a specific fluorescent phage endolysin for in situ detection of Clostridium species associated with cheese spoilage (2017)

Late blowing defect (LBD) is a major cause of spoilage in cheeses, caused by the growth of Clostridium spp. in the cheese matrix. We investigated the application of CTP1L, a bacteriophage endolysin active against Clostridium tyrobutyricum, and its enzymatically active and cell wall-binding domains (EAD and CBD) attached to green fluorescent protein (GFP) to detect dairy-related Clostridium species by fluorescence microscopy. GFP-CTP1L and GFP-CBD demonstrated specificity for Clostridium spp. by labelling 15 and 17 of 20 Clostridium strains, respectively, but neither bound to other members of the cheese microbiota. However, GFP-EAD did not label any Clostridium strain tested. Unexpectedly, GFP-CTP1L and GFP-CBD were also able to bind to clostridial spores. In addition, GFP-CBD allowed us to visualize the vegetative cells of C. tyrobutyricum directly in the matrix of a LBD cheese. Site-directed mutants of GFP-CTP1L and GFP-CBD were made to examine the amino acids involved in binding and oligomer formation. Oligomerization was not essential for binding, but specific mutations in the CBD which affected oligomer formation also affected binding and lytic activity. We conclude that GFP-CTP1L and GFP-CBD could be good biomarkers for rapid detection of Clostridium spores in milk, so measures can be taken for the prevention of LBD in cheese, and also provide effective tools to study the development of Clostridium populations during cheese ripening.
A new power control algorithm in CDMA systems (2005)

Next generation wireless networks are mainly designed to support intermittent packetized data traffic. This situation raises the question of how to do power control for information sources other than voice. To explore this issue, we utilize the delay insensitive property of the data traffic to transmit packets when the channel condition is good and stop transmission when the channel condition is bad. An algorithm is proposed to control the transmission power based on signal-to-interference ratio estimation in a code-division multiple-access (CDMA) mobile radio system under multipath environment. Simulation results show that significant performance improvement has been achieved.
Simulation of laparoscopic ultrasound imaging and suturing of the bile duct using silicone (2022)

The laparoscopic treatment of gallstone is a complex procedure requiring multiple skills, notably laparoscopic ultrasounds imaging and laparoscopic suturing. This procedure has many benefits comparing to open surgery, but still fail to be generalised because of these challenging steps. Surgical simulation can provide a useful way to train for the complex skills required by the surgery in a safe environment. This study focuses on the evaluation of the utilisation of silicone to create a simulator for this procedure. Silicone samples are tested quantitively and qualitatively. The qualitative evaluation compares the ultrasound examination of the silicone samples to the images of ultrasound captured during a real procedure. For the quantitative evaluation, the density, the speed of sound in the material, and the mechanical properties are measured and compared to the properties of the soft tissues. The qualitative evaluation shows that silicone requires the addition of scattering agents to be visible using ultrasound, especially for the hardest silicones which are the most suitable to simulate the bile duct in term of mechanical properties. The quantitative evaluation shows that the density of silicone and the Young modulus are close to the properties of soft tissues, but the speed of sound is slower in the silicone, which results in deformed images. A solution is to perform image processing, which can lead to a more realistic appearance of the images.
Toxicity evaluation of wastewater from the pharmaceutical industry to aquatic organisms (1999)

The aim of our research was to evaluate the acute and chronic toxicity of wastewater from the pharmaceutical industry to some aquatic organisms. The toxicity of three 24h proportional samples of wastewater was determined with the acute toxicity tests using the bacterium Vibrio fischeri and daphnid Daphnia magna. The inhibition of bacterial luminescence was measured after a 30 min exposure period and the immobility of daphnids was determined after 24 and 48h. The chronic effects on daphnid survival and reproduction were observed for three weeks. The toxicity tests indicated that all investigated samples were acutely toxic to the organisms, but in each sample the responses of bacteria and daphnids were quite different. Acute and chronic effects on daphnids were observed when testing the first sample of wastewater, but no influence on bacteria was determined. The second sample was acutely toxic to both organisms. The third sample was toxic only to bacteria, while no influence on daphnid survival and reproduction was found. The reason for the different toxicity of the samples lay in their compositions. The comparison between chemical analyses and toxicity data showed that for daphnids the main cause of toxic effects was zinc.
智利的生活用纸市场：居家用市场日渐成熟，居家外用市场存在机遇 (2016)

在智利待一段时间后，您可能会认为它不属于拉丁美洲。与拉美其他国家相比，智利沿用的是德国式效率。您也许会说，与哥伦比亚人或巴西人相比，智利人异常严肃。不断发展的中产阶级以及大幅提高的可支配收入水平是形成这个国家消费者行为习惯的重要因素。
A 60ns 16Mb Flash EEPROM With Program And Erase Sequence Controller (1991)

An erase and program control system is used in this 60ns 16Mb flash EEPROM intended for internal and external storage in the palm-top and notebook personal computers. The stackedgate flash EEPROM demonstrates that an electrically-erasable nonvolatile memory can be constructed in almost the same chip area as UV-erasable EPROM.1• 2 However, there are several problems to be solved in high-density flash EEPROM beyond 16Mb. The problems related to the erasure operation are: 1) overerasure of the 16Mb memory array, 2) large Vpp current caused by the band-to-band tunneling at the source region overlapping the floating gate of memory cells, and 3) long erasure time resulting from programming-before-erasure.
Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney (1994)

Complementary DNAs encoding rat kidney chloride channels (ClC-K2L and ClC-K2S) were isolated by a polymerase chain reaction cloning strategy. Degenerate primers were designed based on the significant amino acid identity of the previously cloned chloride channels (ClC-0, -1, -2, and -K1). The 687-amino acid protein encoded by ClC-K2L is about 80% identical to rat ClC-K1 and about 40% identical to ClC-0, -1, and -2. ClC-K2S encodes a 632-amino acid protein in which 55 amino acids containing the putative second membrane-spanning domain of ClC-K2L are deleted. Chloride currents induced by both clones were very similar in terms of inhibitor sensitivity and anion selectivity (Br- > I- > Cl- >> cyclamate-). Northern blot with total ClC-K2L as a probe under high stringency revealed its message predominantly in kidney, especially in the outer and inner medulla. Reverse transcription polymerase chain reaction technique using microdissected nephron segments revealed that the main site of expression of both clones in kidney was the thick ascending limb of Henle's loop and collecting ducts, where the existence of a variety of chloride channels and their importance for maintaining body fluid homeostasis have been demonstrated. These results suggest that ClC-K2L and -K2S are chloride channels in the thick ascending limb and collecting ducts and may be important routes for transcellular chloride transport like ClC-K1.
Collective instructional scaffolding in English as a Second Language classrooms (2005)

This article proposes a contextual, multimodal model of instructional scaffolding as teacher-led, task-enabling activity. The model is developed from analysis of authentic classroom interaction from schools participating in the ESL (English as a Second Language) Scaffolding action research project (2001–2003), as well as drawing on sociocultural research literature relating to scaffolding. It is hoped that the model will contribute to an understanding of the nature and value of inclusive pedagogies that specifically address the language, literacy and cultural learning needs of ESL students in schools.
Methamphetamine Effects on Cognitive Processing During Extended Wakefulness (1996)

We examined the effects of both 5- and 10-mg/7O kg body weight of d-methamphetamine HCl on high event rate vigilance and tracking performance in a 13.5-hr sustained-performance session during one night of sleep loss. At 0116 hours participants were administered either a 5 mg/70 kg oral dose of d-methamphetamine (n=10), 10 mg/70 kg d-methamphetamine (n=10), or a placebo (n=10) using standard double-blind procedures. Performance on all measures degraded markedly during the night in the placebo group. Both the 5- and 10-mg methamphetamines treatment reversed an initial decline in d', and reversed increases in nonresponses (lapses) and tracking error within approximately 3 hr of administration. No evidence that amphetamine treatment increased impulsive responding (fast guesses) was observed. The magnitude of the performance effects of the methamphetamine treatments was similar at 3 hr postadministration. However, the effects of the 5-mg dose were shorter-lived, disappearing by the last testing session (6.5 hr postadministration), whereas effects of the 10-mg dose tended to remain throughout testing. Both amphetamine treatments decreased subjective sleepiness during the night and tended to increase subjective sleep latencies during a post-testing sleep period.