gebhart/patrepeval huggingface dataset:
Transducing methyltransferase activity into electrical signals in a carbon nanotube–DNA device (2011)

This study creates a device where the DNA is electronically integrated to serve as both the biological target and electrical transducer in a CNT-DNA-CNT device. We detect DNA binding and methylation by the methyltransferase M.SssI at the single molecule level. We demonstrate sequence-specific, reversible binding of M.SssI and protein-catalyzed methylation that alters the protein-binding affinity of the device. This device, which relies on the exquisite electrical sensitivity of DNA, represents a unique route for the specific, single molecule detection of enzymatic activity.
Valuing the Treasury's Capital Assistance Program (2011)

The Capital Assistance Program (CAP) was created by the U.S. government in February 2009 to provide backup capital to large financial institutions unable to raise sufficient capital from private investors. Under the terms of the CAP, a participating bank receives contingent capital by issuing preferred shares to the Treasury combined with embedded options for both parties: The bank gets the option to redeem the shares or convert them to common equity, with conversion mandatory after seven years; the Treasury earns dividends on the preferred shares and gets warrants on the bank's common equity. We develop a contingent claims framework in which to estimate market values of these CAP securities. The interaction between the competing options held by the buyer and issuer of these securities creates a game between the two parties, and our approach captures this strategic element of the joint valuation problem and clarifies the incentives it creates. We apply our method to the 18 publicly held bank holding companies that participated in the Supervisory Capital Assessment Program (the stress test) launched together with the CAP. On average, we estimate that compared to a market transaction, the CAP securities carry a net value of approximately 30% of the capital invested for a bank participating to the maximum extent allowed under the terms of the program. We also find that the net value varies widely across banks. We compare our estimates with abnormal stock price returns for the stress test banks at the time the terms of the CAP were announced; we find correlations between 0.78 and 0.85, depending on the precise choice of period and set of banks included. These results suggest that our valuation aligns with shareholder perception of the value of the program, prompting questions about industry reactions and the overall impact of the program. This paper was accepted by Wei Xiong, finance.
Specific In Vivo Roles for E2Fs in Differentiation and Development (2007)

E2Fs have been historically considered as key interacting factors for the retinoblastoma (Rb) family of pocket proteins, acting as universal regulators of cell cycle progression. Often exhibiting overlapping function, deregulated E2F activity is thought to cancer or cell death. While early reports hypothesized that E2Fs may be capable of regulating distinct functions beyond proliferation, several recent reports have characterized increasingly diverse, context dependent functions for different E2Fs in vivo, often in what appears to a manner beyond traditional cell cycle regulation. Ironically, many of these new functions are still mediated through the classical cell cycle regulatory Rb family of interacting factors. Here we review the recent advances, focusing on differentiation and development, to emphasize that E2F function is likely more complex than the simple model suggests, capable of exhibiting both specificity of function, and roles beyond cell cycle progression in vivo.
Non‐label homogeneous protein detection based on laser interferometric photo‐thermal displacement measurement using aptamers (2010)

Photo-thermal displacement measurement by laser interferometry involves the measurement of temperature change caused by illumination of the sample. To develop a system of detecting unlabeled homogeneous proteins based on laser interferometric measurement of photo-thermal displacement, we studied the interaction between aptamers and their target molecules by using thrombin and the thrombin aptamer as a model target and ligand, respectively. Because of the energy consumed by aptamer-thrombin interactions, the signals obtained from solutions containing aptamer-thrombin mixtures varied depending on the thrombin concentration. We propose that this method involving the use of aptamers and photo-thermal displacement measurement will provide a biomolecular detection system for rapid diagnosis.
Sustained release bioadhesive effervescent ketoconazole microcapsules tabletted for vaginal delivery (2002)

Microcapsules of ketoconazole with 1:1 and 1:2 core-wall ratios were prepared by means of the phase separation technique using sodium carboxymethylcellulose as a coating material. The microcapsules were mixed with effervescent granules and were tabletted. Dissolution studies of microcapsules, tabletted microcapsules and commercial ovules were carried out with a new basket method (horizontal rotating basket). A good sustained action was obtained with tablets. Micromeritic investigations were carried out on microcapsules in order to standardize the microcapsule product and to optimize the pilot production of the dosage forms prepared with these microcapsules. Bulk volume and weight, tapping volume and weight, fluidity, angle of repose, weight deviation, relative deviation, particle size distribution, density and porosity values of the microcapsules were determined. In addition, to evaluate whether some kind of glidant will be needed during tabletting of microcapsules, the Hausner ratio o and consolidaton index were also calculated and it may be concluded that microcapsules do not need any glidant.
Wipe Scene Change Detector For Segmenting Uncompressed Video Sequences (2005)

The use of wipes in video production to smooth the transition between two consecutive scenes complicates subsequent video compression, video editing, and video database indexing. It is important to detect the wipe region in order to improve the quality of the compressed video or to allow automatic parsing of the video for the purpose of editing and data base indexing. In this paper, a model is developed for the wipe region and is used to derive the statistical characteristics of the frames in the wipe region. A wipe detector that exploits the linear change in the means and the variances of the frames in the wipe region is developed. The developed wipe detector is implemented and tested with video sequences containing wipes of different types and lengths. Simulation results indicate that wipe regions are well represented by the developed wipe model, and that the developed wipe detector is robust to wipe type and length.
Colorimetric High-Throughput Screen for Detection of Heme Crystallization Inhibitors (2009)

Malaria infects 500 million people annually, a number that is likely to rise as drug resistance to currently used antimalarials increases. During its intraerythrocytic stage, the causative parasite, Plasmodium falciparum, metabolizes hemoglobin and releases toxic heme, which is neutralized by a parasite-specific crystallization mechanism to form hemozoin. Evidence suggests that chloroquine, the most successful antimalarial agent in history, acts by disrupting the formation of hemozoin. Here we describe the development of a 384-well microtiter plate screen to detect small molecules that can also disrupt heme crystallization. This assay, which is based on a colorimetric assay developed by Ncokazi and Egan (K. K. Ncokazi and T. J. Egan, Anal. Biochem. 338:306-319, 2005), requires no parasites or parasite-derived reagents and no radioactive materials and is suitable for a high-throughput screening platform. The assay's reproducibility and large dynamic range are reflected by a Z factor of 0.74. A pilot screen of 16,000 small molecules belonging to diverse structural classes was conducted. The results of the target-based assay were compared with a whole-parasite viability assay of the same small molecules to identify small molecules active in both assays.
3D Interconnected Binder-Free Electrospun MnO@C Nanofibers for Supercapacitor Devices (2018)

Rational design of binder-free materials with high cyclic stability and high conductivity is a great need for high performance supercapacitors. We demonstrate a facile one-step synthesis method of binder-free MnO@C nanofibers as electrodes for supercapacitor applications. The topology of the fabricated nanofibers was investigated using FESEM and HRTEM. The X-ray photoelectron spectroscopy (XPS) and the X-ray diffraction (XRD) analyses confirm the formation of the MnO structure. The electrospun MnO@C electrodes achieve high specific capacitance of 578 F/g at 1 A/g with an outstanding cycling performance. The electrodes also show 127% capacity increasing after 3000 cycles. An asymmetric supercapacitor composed of activated carbon as the negative electrode and MnO@C as the positive electrode shows an ultrahigh energy density of 35.5 Wh/kg with a power density of 1000 W/kg. The device shows a superior columbic efficiency, cycle life, and capacity retention.
Network performance analysis of a PIC-based reconfigurable add-drop multiplexer for multiband applications (2023)

To reduce costs and simplify operations, network operators are deploying the latest network devices that are power efficient and compact. In this paper, a detailed comparison is made between the design of a reconfigurable add-drop multiplexer (ROADM) based on an integrated circuit (PIC) and the state-of-the-art ROADM devices. In particular, the performance of the device in terms of frequency response parameters is presented in the paper in comparison with the state-of-the-art ROADMs. The proposed PIC based ROADM can operate in a multi-band scenario, including C+L+S bands, and is potentially scalable to many output fibers and routed channels while maintaining a small footprint. A detailed network performance analysis is performed with the proposed PIC-based ROADM device and its impact on the network. Due to increasing traffic demand, the current optical transport infrastructure is experiencing capacity problems: two possible solutions are Spatial Division Multiplexing (SDM) and Bandwidth Division Multiplexing (BDM), which both allow capacity expansion of the existing infrastructure. We have studied the network performance of the proposed ROADM device on the Spain-E network and performed a detailed comparison for the SDM and BDM scenarios. Compared to the SDM approach, which requires the deployment of additional fiber, the cost-effective BDM scenario can better utilize capacity without installing new fiber infrastructure or using dark fibers.
Plasma amyloid-β, Aβ1-42, load is reduced by haemodialysis (2006)

Patients with chronic renal failure treated with haemodialysis have vascular risk factors that, in the general population, are associated with increased prevalence of Alzheimer's disease (AD). Patients in haemodialysis, however, present different kinds of dementia but they do not have an increased risk of AD. We have hypothesized that amyloid-beta (Abeta)1-42 is washed out from plasma during the dialysis and that this procedure enhances Abeta elimination and reduces the risk of AD. We have measured plasma Abeta1-42 levels in 11 patients with renal failure, before and after haemodialysis. A single procedure reduced the plasma Abeta levels in all subjects with a mean decrement of 30% of baseline. Since Abeta deposition could be altered by certain metals like Cu and Zn, we have also measured the effects of dialysis on the levels of these ions in plasma. We found no changes in levels of Cu and Zn after dialysis. Haemodialysis, therefore, reduces very effectively plasma Abeta without modifying Cu and Zn levels. The potential use of this strategy in patients with AD requires further investigation.
[Alternative Splicing Detection as Biomarker Candidates for Cancer Diagnosis and Treatment with Establishment of Clinical Biobank in Chiba University]. (2015)

Alternative splicing is a fundamental process of gene regulation that contributes to protein diversity, a common phenomenon in the mammalian genome. Alternative splicing events not only happen in the normal gene regulation process, but are also closely related to certain diseases, including cancer. In this review, we briefly demonstrate the proof of concept (POC) of the relationship between alternative splicing and DNA damage, and describe the associations among alternative splicing and cancer pathogenesis, DNA damage, and gastrointestinal cancers. We discuss whether alternative splicing leads to genetic instability, which is considered to be a driving force for tumorigenesis. FUSE-binding protein (FBP) -interacting repressor (FIR) is a c-myc transcriptional suppressor. A splice variant of FIR that lacks exon 2 in the transcriptional repressor domain (FIRΔexon2), upregulates c-myc transcription by inactivating wild-type FIR. FIR+/- mice exhibited marked c-myc mRNA upregulation, particularly in the peripheral blood (PB), without any significant pathogenic phenotype. Because the single knockout of TP53 generates thymic lymphoma, FIR+/-TP53-/- mice developed T-cell type acute lymphocytic/lymphoblastic leukemia (T-ALL) with increased organ or bone marrow invasion and showed a poor prognosis. After describing the POC of alternative splicing of FIR in DNA damage and carcinogenesis, clinical application for cancer diagnosis and treatment by FIR/FIRΔexon2 was briefly summarized. Chiba University has prepared a biobank to support studies to develop biomarker detection, molecular diagnosis, and "Omics" research. In conclusion, alternative splicing of FIR, generating FIRΔexon2, potentially contributes to not only colorectal carcinogenesis, but also leukemogenesis, and a better understanding of the role and mechanism of alternative splicing in tumorigenesis may reveal new directions for cancer biomarker detection.
Crystallization and preliminary cryogenic X‐ray diffraction analyses of protein L‐isoaspartyl O‐methyltransferase from human fetal brain (1997)

Recombinant human fetal brain protein L-isoaspartyl O-methyltransferase, EC 2.1.1.77, was crystallized in PEG 8000 with adenosine homocysteine by a macroseeding technique. The space group was P21 with a = 47.4 Å, b = 53.9 Å, c = 48.7 Å and β = 116.4° for cryofrozen crystals at 90 K. The crystals diffracted to 2.1 Å and have one molecule per asymmetric unit. Proteins 28:457–460, 1997. © 1997 Wiley-Liss, Inc.
Development of wide band negative permeability structure (2015)

In recent year, negative permittivity or/and permeability materials for microwave region have been proposed. These structures can be applied to enhance an antenna property such as super gain. On the other hand, bandwidths of these structures are relatively narrow. The narrow bandwidth sometime becomes an obstacle to develop applications which utilize these materials. In this paper, we develop new wideband negative permeability structures.
Mixed depression and anxiety: serotonin1A receptors as a common pharmacologic link. (1997)

Although depressive and anxious symptoms frequently coexist, most studies tend to dichotomize anxiety disorders from depression. Consequently, pharmacologic agents are designated as antidepressants or anxiolytics. A number of developments are reversing this trend. One is changes in conceptualization of generalized anxiety disorder (GAD) and major depressive disorder to recognize the frequent existence of simultaneous symptoms of anxiety and depression in patients with related affective and anxiety disorders. A second is the increasing recognition that subsyndromal symptoms of anxiety and depression frequently exist that do not reach thresholds for GAD or depression but that may decompensate to overt anxiety disorder or depression. A third is the discovery of partial agonists for serotonin1A receptor subtypes that have promising efficacy in mixed depression and anxiety.
ChemInform Abstract: SYNTH. VON TRANS‐9‐OXO‐ UND TRANS‐9‐HYDROXY‐DECEN‐(2)‐SAEURE (1971)

Abstract Die durch etwa vierstündige Reaktion der Chlorheptansäure (Ia) mit Brom in Thionylchlorid bei 65‐75°C (und Verseifung des entstehenden Säurechlorids) dargestellte Bromverbindung (Ib) (Ausbeute 85%) läßt sich durch vierstündige Behandlung mit K‐tert.‐butylat in tert.‐Butanol bei 80°C zur Chlorheptensäure (II) (51%) dehydrobromieren; als Nebenprodukt entsteht trans‐7‐Chlor‐hepten‐(3)‐säure.
Tbit/Inch 2 Data Storage Using Scanning Nonlinear Dielectric Microscopy (2003)

Nano-sized inverted domain dots in ferroelectric materials is a technology with potential applications in ultrahigh-density rewritable data storage systems. Up to now, we have studied domain inversion characteristics of stoichiometric and congruent LiTaO 3 single crystals in nanoscopic area using scanning nonlinear dielectric microscopy (SNDM), which is the technique for observing ferroelectric polarization distribution with sub-nanometer resolution. In this study, we have revealed nano-sized inverted domain remained stably for a long time, and successfully formed inverted domain dots at a data density of 1.50 Tbit/inch 2, representing the highest memory density for rewritable electric data storage reported to date. Keywords: Ferroelectric Data StorageScanning Nonlinear Dielectric MicroscopyTbit/inch
On the Performance of Opportunistic Cooperative Wireless Networks (2008)

The aim of this paper is to study the impact of channel state information on the design of cooperative transmission protocols. This is motivated by the fact that the performance gain achieved by cooperative diversity comes at the price of the extra bandwidth resource consumption. Several opportunistic relaying strategies are developed to fully utilize the different types of a priori channel information. The analytical and numerical results demonstrate that the use of such a priori information increases the spectral efficiency of cooperative diversity, especially at low signal-to-noise ratio.
The Timing Group Delay (TGD) Correction and GPS Timing Biases (2007)

The Timing Group Delay (TGD) is the bias difference between each GPS satellites P-code transmissions at the L1 and L2 frequencies. They are broadcast in the GPS navigation message so that single-frequency users can use them in conjunction with ionosphere delay estimates, such as the Klobuchar ionosphere model, to improve their position determination and to better derive UTC(USNO), which is the U.S. Naval Observatory’s realization of Coordinated Universal Time (UTC). There are at most a few nanoseconds of bias in the TGDs with respect to the official GPS monitor receivers maintained at the USNO. These are within the calibration uncertainties. This paper analyzes the problem, and outlines an approach to a solution.
Studies on the function of chloroplast acyl lipids (1982)

Conference Article| August 01 1982 Studies on the function of chloroplast acyl lipids ADRIAN A. FOLEY; ADRIAN A. FOLEY 1Department of Biochemistry, University College, P.O. Box 78, Cardiff CF1 1XL, Wales, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOHN L. HARWOOD JOHN L. HARWOOD 2Department of Biochemistry, University College, P.O. Box 78, Cardiff CF1 1XL, Wales, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1982) 10 (4): 247–248. https://doi.org/10.1042/bst0100247 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation ADRIAN A. FOLEY, JOHN L. HARWOOD; Studies on the function of chloroplast acyl lipids. Biochem Soc Trans 1 August 1982; 10 (4): 247–248. doi: https://doi.org/10.1042/bst0100247 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1982 Biochemical Society1982 Article PDF first page preview Close Modal You do not currently have access to this content.
Verfahren der Dateninterpretation (1993)

Zur Auswertung der über Interviews und gegebenenfalls über Beobachtungen erhobenen Daten sowie des dokumentarischen Materials, also der in Textwirklichkeiten transformierten und damit der soziologischen Analyse überhaupt erst verfügbar gemachten ‘gelebten’ Wirklichkeiten (vgl. Soeffner 1989, bes. S. 66ff und 98ff; vgl. auch Gross 1981), verfügen wir heute bekanntlich über eine beträchtliche Zahl ‘qualitativer’ Methoden, die zur Analyse von Texten samt und sonders geeignet sind, von denen aber keine einzelne beanspruchen kann (und dies — mit Einschränkungen — auch nicht will), die Methode schlechthin zu sein. Denn generell gilt, daß das jeweilige Forschungsinteresse den Umgang mit dem Material anleitet. Methoden haben nämlich keinen Eigen-Wert — auch, und schon garnicht, in den Sozialwissenschaften. Methoden sind nur dazu da, daß man (sozial-)wissenschaftliche Probleme ‘in den Griff bekommt (dazu aber sind sie ‘in der Tat’ grundsätzlich nützlich). Dieses Problem bekommt man besser mit dieser, und jenes Problem bekommt man besser mit jener Methode’ in den Griff. Jede einzelne Methode gibt eben Antwort auf einen spezifischen Fragetyp, der an den Text gestellt wird. Interessant ist also ‘eigentlich’ nicht die Methodenfrage, sondern die Frage danach, welchem Problem man sich stellt (dann erst wiederum stellt sich einem die Frage, mit welcher Methode man dies am besten tut).
Glutamic acid decarboxylase and somatostatin immunoreactivities in rat visual cortex (1986)

Antibodies to glutamic acid decarboxylase (GAD) and somatostatin (SS) were used to determine the laminar distribution and morphology of GAD- and SS-immunoreactive neurons and terminals in rat visual cortex. The present study demonstrates that GAD-immunoreactive neurons constitute several morphologically distinct subclasses of neurons in rat visual cortex. These subclasses of neurons can be distinguished by differences in soma size, soma shape, dendritic branching patterns, axonal arborizations, and location in the neuropil. GAD-immunoreactive neurons are found throughout all layers of visual cortex. They have nonpyramidal morphology and constitute roughly 15% of the total neuronal population. The laminar pattern of GAD-immunoreactive puncta is uneven, with a prominent band of terminals in layer IV. Numerous large GAD-positive puncta surround the somata and proximal dendrites of pyramidal cells in layers II, III, and V. SS-immunoreactive neurons constitute a less numerous and more restricted population of nonpyramidal neurons. Their somata are located mainly in layers II, III, V, and VI. Very few, if any, SS-immunoreactive neurons are found in layers I and IV. SS-immunoreactive terminals are arranged along vertical and diagonal collateral branches that have a beaded appearance. Finally, many neurons in the supra- and infragranular layers and in the white matter are immunoreactive to both glutamic acid decarboxylase and somatostatin. This coexistence of immunoreactivity to both GAD and SS may characterize a broad subclass of cortical nonpyramidal neurons.
ChemInform Abstract: Rapid Assembly of Substituted Dihydrocyclohepta[3,4]pyrrolo[1,2‐a]indoles via a Novel, Carbene‐Based, Rearrangement Reaction. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.