gebhart/patrepeval huggingface dataset:
Abstract 1838: Efficacy of ribonuclease QBI-139 in combination with standard of care therapies (2012)

Abstract RNA has been recognized as a drug target for cancer therapy, as evidenced by the ongoing clinical trials of RNAi and antisense therapies. An alternative approach that circumvents the delivery and stability issues of those drugs is to harness the activity of naturally occurring RNA degradation enzymes. Human ribonuclease (RNase) variants have been generated with diminished binding to their natural inhibitor inside cells, which allows the new proteins to kill cancer cells. One of these RNase variants, referred to as QBI-139, demonstrated efficacy against multiple tumor types in xenograft models of human cancer and was selected for an ongoing first in human Phase I clinical trial. Non-small cell lung and ovarian cancer are two of the indications where QBI-139 has shown significant efficacy as a single agent in xenograft models. In planning for the next stage of clinical trials, the impact of combinations of QBI-139 plus standard of care agents in these diseases was determined both in vitro and in vivo. QBI-139 showed additive and synergistic activity in combination with cisplatin and docetaxel, which are standard of care for non-small cell lung and ovarian cancer, respectively. Fixed ratios of QBI-139 and the combination drug based on their EC50 values were tested. The Combination Index (CI) was determined using median effect analysis. Synergy was demonstrated with QBI-139 in combination with cisplatin against non-small cell lung cancer (A549 and H1975). An additive effect of QBI-139 and cisplatin was seen in ovarian (Ovcar-3) cancer. In ovarian cancer (SK-OV-3), a combination of docetaxel and QBI-139 was synergistic with QBI-139. The benefit of the combinations were repeated in xenograft models of both cancers and were signifcat relative to each agent alone. Non-small cell lung and ovarian cancer represent critical unmet needs and new, differentiated treatment approaches such as QBI-139 combination therapy are critical. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1838. doi:1538-7445.AM2012-1838
p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats (1997)

Recent studies suggest that superoxide production by the NADPH/NADH oxidase may be involved in smooth muscle cell growth and the pathogenesis of hypertension. We previously showed that angiotensin II (Ang II) activates a p22phox-based NADPH/NADH oxidase in cultured rat vascular smooth muscle cells and in animals made hypertensive by infusion of Ang II. To investigate the mechanism responsible for this increased oxidase activity, we examined p22phox mRNA expression in rats made hypertensive by implanting an osmotic minipump that delivered Ang II (0.7 mg/kg per day). Blood pressure began to increase 3 days after the start of Ang II infusion and remained elevated for up to 14 days. Expression of p22phox mRNA in aorta was also increased after 3 days and reached a maximum increase of 338±41% by 5 days after pump implantation compared with the value after sham operation. This increase in mRNA expression was accompanied by an increase in the content of the corresponding cytochrome (twofold) and NADPH oxidase activity (179±11% of that in sham-operated rats 5 days after pump implantation). Treatment with the antihypertensive agents losartan (25 mg/kg per day) or hydralazine (15 mg/kg per day) inhibited this upregulation of mRNA levels and activity. Furthermore, infusion of recombinant heparin-binding superoxide dismutase decreased both blood pressure and p22phox mRNA expression. In situ hybridization of aortic tissue showed that p22phox mRNA was expressed in medial smooth muscle as well as in the adventitia. These findings suggest that Ang II–induced hypertension activates the NADPH/NADH oxidase system by upregulating mRNA levels of one or several components of this oxidase system, including the p22phox, and that the NADPH/NADH oxidase system is associated with the pathology of hypertension in vivo.
Ionic balance, biomass production, and organic nitrogen as affected by salinity and nitrogen source in annual ryegrass (1997)

Abstract Studies on the effects of salinity and nitrogen (N) fertilization on ionic balance, biomass, and organic N production of annual ryegrass (Lolium multiflorum Lam.) were conducted. Plants grown in sand were irrigated with nutrient solution with an electrical conductivity of 2 or 11.2 dS#lbm‐1, and N in the form of sodium nitrate (NaNO3), ammonium nitrate (NH4NO3), or ammonium sulfate [(NH4)2SO4] ranging from 0.5 to 9.0 mM. Salinity increased the concentration of total inorganic cations (C) in plants and specifically sodium (Na) by more than 3‐fold higher in plants grown at high salinity as compared with plants at low salinity. Sodium (Na) concentration in roots was higher than in shoots irrespective of the salinity level, suggesting a restriction of Na transport from roots to shoots. The concentration of total inorganic anions (A) increased with salinity and when plants were supplied with nitrate (NO3), salinity increased the concentrations of NO3 and chloride (Cl) in plants. Increasing salinity and N concentration in the growth medium increased organic anions concentration in plants, estimated as the difference between C and A. The effect of different N sources on C‐A followed the order: NH4NO3 > NO3 > ammonium (NH4). The base of organic anions and inorganic ions with salinity contributed significantly to the osmotic potential of plants shoots and roots. Changes in C affected N and organic acids metabolism in plants, since C were highly correlated (p=0.0001) with C‐A and organic N (Norg) concentrations regardless of the salinity level or N source in the nutrient solutions. A high and positive linear dependency was found between Norg and C‐A in plants grown at high and low salinity levels and different N sources, pointing out the close relationship between Norg and organic anions on metabolism under these conditions. The amount of biomass produced was correlated positively with organic anion concentration in plants exposed to different salinity levels. Plant biomass increased with N concentration in the nutrient solution regardless of the salinity level applied. Biomass accumulation decreased while Norg concentration increased with salinity. Organic N content remained unaffected in plants exposed to salinity when grown in N less than 9.0 mM.
Numerical Investigation of Capabilities for Dynamic Self-Shading through Shape Changing Building Surface Tiles (2017)

A concept for a smart material morphing building surface tile that would utilize adaptive surface wrinkle patterns to improve solar interaction is explored. The effect of the wrinkle patterns is numerically investigated in the context of an objective to reduce solar irradiance entering buildings by changing the shape of the surface (i.e., surface topography) so that the facade is self-shading, thereby reducing energy costs of the building for temperature control. A generally applicable algorithm was utilized and is presented to quantify the area of an arbitrarily shaped/oriented surface that is in shade for any given date/time and geographic location. Numerical case studies are shown that utilize the surface shading algorithm to evaluate the capabilities of various basic wrinkle patterns, both static and dynamically changing, to self-shade a building surface over the course of a day. The results indicate that a morphing wrinkle pattern can substantially increase the amount and duration of surface area in shade over time in comparison to any of the static (non-morphing) patterns, although it is noted that there is an expected tradeoff in the energy cost to change the surface pattern. Furthermore, it is shown that as the location of the proposed tile on the building facade changes, the optimal wrinkle pattern changes as well.
New Robust Bleomycin Analogues:  Synthesis, Spectroscopy, and Crystal Structures of the Copper(II) Complexes. (1999)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionNew Robust Bleomycin Analogues: Synthesis, Spectroscopy, and Crystal Structures of the Copper(II) Complexes.Hiromasa Kurosaki, Kentarou Hayashi, Yoshinobu Ishikawa, Masafumi Goto, Kazufumi Inada, Isao Taniguchi, Mitsuhiko Shionoya, and Eiichi KimuraCite this: Inorg. Chem. 1999, 38, 19, 4372Publication Date (Web):September 3, 1999Publication History Published online3 September 1999Published inissue 1 September 1999https://pubs.acs.org/doi/10.1021/ic990898xhttps://doi.org/10.1021/ic990898xcorrectionACS PublicationsCopyright © 1999 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views223Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (16 KB) Get e-Alertsclose Get e-Alerts
Optical frequency mixers for WDM and TDM applications (2002)

All-optical wavelength conversion for WDM, gated mixing for TDM, and spectral inversion for dispersion correction have been demonstrated in simple three-wave mixing and in cascade mixing devices. Low conversion loss (3 dB) and wide bandwidths (70 nm) can be obtained with moderate pump powers (tens of mW).
Impact Characterization of New Composite Materials (1986)

Drop-weight instrumented impact tests were used in conjunction with ultrasonic C-scan inspection to characterize the impact responses of several new graphitefiber composite material systems. The AS4/Hercules 3501-6 graphite/epoxy was compared with the newer AS4/Hercules 2220-1, Celion high-strain/Narmco 5245 and IM6/Narmco 5245C systems in the 394 K (250°F) service category. The materials tested in the 450 K (350°F) service category were T300/Avco 130B, T300/Hexcel 81-5, T300/U.S. Polymeric V378A, XAS/Hysol 9101-3, and HX/Hexcel 1516 graphite/bismaleimides. A material ranking is given, along with measured impact parameters and impact energy versus damage relationships. The impact behavior of all four 394 K (250°F) systems was similar, except that IM6/5245C had the highest impact resistance. The bismaleimides had incipient damage levels similar to those of the epoxies but were more easily punctured. The impact resistance of the five 450 K (350°F) systems was similar except that T300/130B had the lowest impact resistance.
New soft materials? – Strong luminescence of rare earth compounds in ionic liquids (2005)

status: Published
Adherence with the National Cholesterol Education Program guidelines in men with chronic spinal cord injury (2011)

Dyslipidemia is common in men age 45-70 with chronic SCI and no evidence of clinical cardiovascular disease. Rates of treatment and control of dyslipidemia in this population are far from optimal, especially among the intermediate- and high-risk groups.
ChemInform Abstract: New Synthetic Routes for the Preparation of 2′‐C‐Methylene Nucleosides. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A diamond anvil cell with resistive heating for high pressure and high temperature x-ray diffraction and absorption studies (2008)

In this paper we describe a prototype of a diamond anvil cell (DAC) for high pressure/high temperature studies. This DAC combines the use of a resistive oven of 250 W power in a very small volume, associated with special conical seats for Boehler-type diamond anvils in order to have a large angular acceptance. To protect the diamond anvils from burning and to avoid the oven oxidation, the heated DAC is enclosed in a vacuum chamber. The assemblage was used to study the melting curve of germanium at high pressure (up to 20 GPa) and high temperature (up to 1200 K) using x-ray diffraction and x-ray absorption spectroscopy.
Strategies of optimizing crop production in rainfed areas (1985)

The paper develops a conceptual model of crop production system in rainfed area with an objective to develop appropriate package of practices for maximising production. The model visualises the arable land as a water storage element from which water is depleted over time due to its utilization in crop growth and is replenished by rains. If the rains are scant the water reservoir in the soil is unable to support the crops. The paper proposes how to seek the best crop yields under moisture conditions sometimes unfavourable to them in varying, degrees. The model comprises five elements besides the natural input in terms of seasonal rains and designed strategies involving rate of fertilizer application, choice of harvest time, cultural practices and possible irrigation through stored rainwater. The five elements of the system are: (i) a region under cultivation, (ii) soil sub-system, (iii) kharif soil crop sub-system, (iv)rabi soil-crop sub--system, and (v) reservoir for run-off water from rain. The outputs of the system are crop yields and the crop wastes both of which are usable and have a value. With the known system characteristics, strategies for optimizing the crop yields can be designed using the system model proposed in this paper.
Effect of Curvature on Shock Loading Response of Aluminum Panels (2011)

Accidental explosions or bomb blasts cause extreme loadings on civilian and military structures. These structures have different curvatures, which affect their blast mitigation properties. Thus a controlled study has been performed to understand the effect of curvature on blast mitigation. The shock tube apparatus was utilized to obtain a controlled blast loading. Aluminum 2024 T3 panels having three different curvatures (infinity, 304.8 mm, and 111.76 mm) were used in the experiments. All the panels had un-deformed dimensions of 203.2 mm × 203.2 mm × 2 mm. A fully clamped boundary condition was applied. Digital Image Correlation (DIC) techniques were applied to obtain full-field in-plane and out-of-plane deformation data and in-plane strain on the back face of the panel. The results show that the panel with a 304.8 mm radius of curvature had a better blast resistance as compared to the other two panels.
WAVEGUIDE COUPLER KICK TO BEAM BUNCH AND CURRENT DEPENDENCY ON SRF CAVITIES (2008)

JLAB SRF cavities employ waveguide type fundamental power couplers (FPC). The FPC design for the 7-cell upgrade cavities was optimized to minimize the dipole field kick. For continuous wave (CW) operation, the forwarding RF power will be at different magnitude to drive the different beam current and cavity gradient. This introduces some deviation from optimized FPC field for varying beam loading. This article analyzes the beam behavior both in centroid kick and head-tail kick under different beam loading conditions.
Fibrin Sealant as a Delivery Vehicle for Sustained and Controlled Release of Chemotherapy Agents (2020)

The desirable effects of most chemotherapy agents depend upon the differences in the proliferation rates between those normal cells that proliferate and the cancer cells that are the target of treatment. Since these rates may be similar, the results are unpleasant side effects that are usually dose-limiting. It is generally believed that the higher the concentration of chemotherapy the tumor can be exposed to and the longer the duration of exposure, the greater the efficacy of the treatment. The effectiveness of most antiproliferative chemotherapy is limited by the severity of these side effects. Fibrin sealant, a gel similar to a natural clot, is formed by mixing concentrates of virally-inactivated human fibrinogen and thrombin solutions. It has been used mostly as a hemostatic and/or adhesive agent in Europe and Canada for over a decade. The results indicate that fibrin sealant may be capable of serving as a delivery system for local/regional therapy of neoplasms in vivo.
Assessing teaching effectiveness in higher education (2019)

Recently, a robust tool for assessment of different teaching methodologies in engineering education has been developed by the consortium of the iTeach project (www.iteach-chemeng.eu). The tool was initially tested for its applicability in teaching units of chemical engineering education, evaluating several educational approaches used to deliver core knowledge and employability competences in different geographical and educational contexts. After some modifications, the framework was subjected to a wider testing, including teaching units that are part of other engineering disciplines, but also, extended to other higher education disciplines. In the presented case-study, the framework, including six metrics, was used in the assessment of two pedagogical approaches, practical instructions via lab and self-instruction delivery, applied in the teaching units Microbiology and Engineering Economy, respectively. Necessary data were collected by online surveys, carried out among four target groups of stakeholders, i.e. academics, employers, graduates and students. The results of this testing will be presented and discussed.
Effect of Anesthesia in Stroke Models (2010)

Many investigators have examined or are examining the effects of focal and global cerebral ischemia on brain physiology, chemistry, and molecular aspects and function. Many animal and cellular models are utilized for these types of studies. However, anesthetics must be used for the in vivo studies, or at least in most animal models of cerebral ischemia. In many of these studies, there has been an intensive search for agents that are neuroprotective for cerebral ischemia. The use of anesthetics may complicate the issues relating to neuroprotection because many anesthetics themselves possess neuroprotective characteristics. This chapter addresses the more commonly used anesthetics for the study of cerebral ischemia. At the conclusion of the chapter, the issues related to why anesthetics have not been successfully used in humans as neuroprotective agents are discussed.
MODELAGEM DA POLIMERIZAÇÃO DO ÁCIDO ACRÍLICO (2015)

RESUMO – Um modelo matematico para polimerizacao do acido acrilico (AA) em um processo batelada e proposto neste trabalho. A partir deste, foi possivel simular o avanco da massa molar media ponderal, e da distribuicao de massas molares. Alem disso, foi possivel estimar parâmetros cineticos,nao disponiveis na literatura,desse sistema reacional. Os resultados obtidos pela modelagem foram validados satisfatoriamente com dados experimentais obtidos em um reator em escala de bancada.
Salmonella typhi 205aTy, a strain with two attenuating auxotrophic characters, for use in laboratory teaching (1987)

The need for p-aminobenzoic acid of a previously reported pab mutant in a Salmonella typhi strain causes loss of virulence (mouse median lethal dose by the intraperitoneal route with mucin, ca. 10(7) CFU, versus less than 200 CFU for related pab+ strains). This strain, however, gave p-aminobenzoic acid-independent revertants at a low frequency (ca. 4 X 10(-10) per bacterium per generation). It was therefore given, by transduction and mutation, a transposon-generated, nonreverting (rate, less than 3 X 10(-11) per bacterium per generation) mutation at purA, causing a requirement for adenine; such a mutation in a wild-type strain caused about the same loss of virulence as the pab mutation. The pab purA strain, 205aTy, has mouse median lethal dose of ca. 5 X 10(7) and is expected to be unable to cause typhoid fever. Since strain 205aTy behaves like a typical Vi-positive S. typhi strain in nearly all common tests, we propose that it is a safe strain for use in laboratory teaching, proficiency testing, and the like.
Cavity-enhanced second harmonic generation via nonlinear-overlap optimization (2015)

We describe an approach based on topology optimization that enables automatic discovery of wavelength-scale photonic structures for achieving high-efficiency second-harmonic generation (SHG). A key distinction from previous formulation and designs that seek to maximize Purcell factors at individual frequencies is that our method not only aims to achieve frequency matching (across an entire octave) and large radiative lifetimes, but also optimizes the equally important nonlinear--coupling figure of merit $\barβ$, involving a complicated spatial overlap-integral between modes. We apply this method to the particular problem of optimizing micropost and grating-slab cavities (one-dimensional multilayered structures) and demonstrate that a variety of material platforms can support modes with the requisite frequencies, large lifetimes $Q &gt; 10^4$, small modal volumes $\sim (λ/n)^3$, and extremely large $\barβ \gtrsim 10^{-2}$, leading to orders of magnitude enhancements in SHG efficiency compared to state of the art photonic designs. Such giant $\barβ$ alleviate the need for ultra-narrow linewidths and thus pave the way for wavelength-scale SHG devices with faster operating timescales and higher tolerance to fabrication imperfections.
Detection of Prostate Cancer Cells in Circulation (2010)

Metode otkrivanja malog broja stanica raka prostate u krvotoku istražuju se prvenstveno kako bi se među bolesnicima s lokaliziranim rakom prostate izdvojili oni koji ce kasnije razviti recidiv ili udaljene metastaze, ali i kao potencijalni prognosticki i prediktivni biljeg u bolesnika s uznapredovalom bolesti. U radu su opisane metode detekcije cirkulirajucih stanica raka prostate, prvenstveno lancana reakcija polimerazom nakon reverzne transkripcije (RT-PCR) i CellSearch, zatim biljezi koji se primjenjuju pri otkrivanju cirkulirajucih stanica raka prostate te njihova osjetljivost i specificnost. Na kraju je opisana moguca klinicka primjena i klinicka vrijednost ove metode s obzirom na rezultate objavljenih istraživanja.
Impact of Water Mist Thickness on Shock Wave Attenuation (2019)

Explosion protection systems for underground structures are designed to create a suppressing barrier between the site of explosion and the facility to be protected. Studies have shown that water mist, provided that its properties are correctly selected, can effectively reduce shock wave overpressure in tunnels. The influence of droplet sizes and concentration of water in mist on shock wave mitigation processes have been studied by various researchers through experiments and modelling. However, the effect of geometric dimensions of mist on shock wave attenuation in tunnels has not been sufficiently studied.
James, William, 1889 January 19 (1877)

offers condolences for WJ's bout with grippe; talks with frustration of his problems with Daly and the theatrical side of writing plays
Comparison of 8-MOP Aqueous Bath and 8-MOP Ethanolic Lotion (Meladinine<sup>®</sup>) in Local PUVA Therapy (1998)

The difference between bath PUVA and lotion PUVA can be described as 'gentle' versus 'strong' therapy. The better therapy depends on clinical indication.