gebhart/patrepeval huggingface dataset:
Perturbing highly conserved spatial relationships in the regulatory domain that controls inducible cat translation (1992)

Chloramphenicol activates translation of cat-86 mRNA by stalling a ribosome in the leader of individual transcripts. Stalling triggers two sequential events: the destabilization of a region of secondary structure that sequesters the cat ribosome-binding site (RBS-C), and the initiation of cat translation. The site of drug-dependent ribosome stalling is dictated by the leader sequence, crb; crb causes a ribosome to stall with its aminoacyl site at leader codon 6. We demonstrate that induction requires the maintenance of a precise spatial relationship between crb and sequences within the left inverted repeat of the secondary structure. Therefore, destabilization of the secondary structure during chloramphenicol induction may result from the interaction of a stalled ribosome with a specific sequence in the secondary structure rather than from non-specific masking of RNA sequences. cat-86 regulation also depends on the distance that separates crb from RBS-C. This interval of 33 nucleotides was incrementally increased and decreased by mutations within a loop in the secondary structure. Shortening the distance between crb and RBS-C by three nucleotides reduced induction by half and a deletion of nine nucleotides abolished induction. Insertion mutations were without effect on induced expression but elevated basal expression. The results indicate that when the A site of a ribosome occupies leader codon 6 the secondary structure is destabilized and there is no interference with entry of a second ribosome at RBS-C. The data further demonstrate that when the A site of a ribosome in the leader is within 30 nucleotides of RBS-C, cat expression decreases. This decrease probably results from competition of the leader ribosome with the ribosome initiating cat translation. Our observations demonstrate that in wild-type cat-86 the distances between crb and the secondary structure, and between crb and RBS-C provide the precise spacing necessary to achieve three interdependent effects: the destabilization of the RNA secondary structure by a ribosome stalled at crb; a lack of competition between a ribosome stalled at crb and the initiating ribosome; and maintenance of a low, but measurable, basal level of cat expression. The spatial relationships identified as necessary for the regulation of cat-86 are conserved in the regulatory regions for five other inducible cat genes.
Use of ANN to simulate the effects of welding process parameters in curved steel plates: residual stresses, strains and distortions (2003)

In large steel fabrication industries such as shipbuilding, and high-speed train guideways, the problem of residual stresses and overall distortion has been and continues to be a major issue. In the last few decades, various research efforts have been directed at the control of the welding process parameters aiming to reduce distortions and residual stresses. Yet, in actual practice, large amounts of resources are still required to rework welds. These costs increase production costs and delay work completion. In the work reported here the Finite Element Method (FEM) is used to simulate the welding process in two-steps; first a non-linear heat transfer step that yields the dynamic temperature distribution throughout the weld seam and the plates, and second, the elasto-plastic analysis, which yields the residual stresses, strains, and the displacements. The responses focused upon were those along the longitudinal cross sections after the welded piece had cooled down to room temperature. An artificial neural network is trained using FEM simulation data for a wide variety of geometric and process parameter combinations. Then, the resulting neural networks is shown to be capable of predicting the welding response without having to carry out a computationally complex, time consuming full finite element analysis. This concept is shown to be a highly effective and efficient way to predict welding responses for welding process design purposes.
Micro-bioreactor array for controlling cellular microenvironments (2007)

High throughput experiments can be used to spatially and temporally investigate the many factors that regulate cell differentiation. We have developed a micro-bioreactor array (MBA) that is fabricated using soft lithography and contains twelve independent micro-bioreactors perfused with culture medium. The MBA enables cultivation of cells that are either attached to substrates or encapsulated in hydrogels, at variable levels of hydrodynamic shear, and with automated image analysis of the expression of cell differentiation markers. The flow and mass transport in the MBA were characterized by computational fluid dynamic (CFD) modeling. The representative MBA configurations were validated using the C2C12 cell line, primary rat cardiac myocytes and human embryonic stem cells (hESCs) (lines H09 and H13). To illustrate the utility of the MBA for controlled studies of hESCs, we established correlations between the expression of smooth muscle actin and cell density for three different flow configurations.
Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B (2015)

ChiCTR-DCS-07000039.
Expedient tandem dehydrogenative alkylation and cyclization reactions under Mn(i)-catalysis (2023)

Sustainable chemical production requires fundamentally new types of catalysts and catalytic technologies.
Incidence of Appendicitis over Time: A Comparative Analysis of an Administrative Healthcare Database and a Pathology-Proven Appendicitis Registry (2016)

The administrative database overestimated the incidence of appendicitis, particularly among perforated appendicitis. Therefore, studies utilizing administrative data to analyze perforated appendicitis should be interpreted cautiously.
MULTITEXCO – High Performance Smart Multifunctional Technical Textiles for the Construction Sector (2015)

The overall objective of the MULTITEXCO project is to scientifically and technologically characterize the latest achievements within the technical textile sector for the development of Guidelines and Pre-normative research, enabling future standards at EU level. These will support the SMEs involved in the construction sector to fully exploit the new generation of multifunctional technical textiles. MULTITEXCO is focusing on key developments in smart textiles for 1/ roadwork and embankments, 2/ structure retrofitting and 3/ fabrics for tensile structures. For each field of application a demonstrator is exemplifying the use and reliability of novel, smart multifunctional fabrics for the construction sector. In this contribution we will show examples for all three application areas, such as for example the use of textile integrated sensors for tensile architecture applications, sensor embedded soil reinforcing fabrics and meshes for masonry retrofitting.
H.264/AVC interleaving for 3G wireless video streaming (2005)

We present a streaming system that utilizes interleaved transmission for real-time H.264/AVC video in 3G wireless environments with benefits shown especially in the presence of link outages. In the 3GPP packet-switched streaming Service Rel. 6, H.264/AVC and its RTP payload format are specified. The RTP payload format allows interleaved transmission of NAL units of H.264/AVC. Our simulations also include audio into the interleaving framework and are conducted within a testbed that emulates a 3G network including block error rates on the physical layer, a buffer for retransmission on the link layer for different error rates, and link outages. The experimental results demonstrate the superior performance of interleaving for typical link outage settings.
Optimizing Acoustic Array Beamforming to Aid a Speech Recognition System (2012)

The iBrutus is a pilot project at the Computer Science and Engineering (CSE) department at OSU which develops human-computer interaction via spoken dialog. The goal of the iBrutus project is to design a kiosk with a talking avatar on a screen which will answer questions at a public event like a football game at a potentially noisy environment like the Ohio Stadium. \n\nIn such an environment, the speech recognition software employed by the system would be ineffective without prior processing to obtain a cleaner speech signal. As a rule of thumb, if the iBrutus could correctly interpret 70% or more words, it could successfully to map the input to a known question/command. To improve the speech recognition rate the author has chosen to research a beamforming algorithm. Such an algorithm combines inputs of from a microphone array to minimize the interference while preserving the desired signal (i.e. speech arriving from a known direction/location).\n\n\nThe goal of the research has been to develop such an algorithm and a means of testing to determine which parameters associated with the algorithm – such as the spatial geometry of the microphone array – will produce the desired speech recognition rate in minimum processing time. The beamforming algorithm designed by the author in MATLAB was frequency based wideband Minimum Variance Distortionless Response (MVDR). Tests showed that at least 70% word recognition rate could be achieved under certain parameter choices. The processing time of the MATLAB-based algorithm is currently larger than desired for use with iBrutus, but there is potential for improvement.
The SuperNO2VA to treat upper airway obstruction and respiratory compromise after major head and neck surgery: a case report (2019)

Postoperative pulmonary complications are common after major neck surgery, with airway compromise a leading cause for hypoxemia, hypercarbia, and reintubation. There are advantages to tracheal extubation upon emergence from anesthesia when appropriate. Recognizing that reintubation in the setting of upper airway obstruction or respiratory compromise may be challenging with presence of a cervical collar or anatomic changes following surgery. We present a 42-year-old man who underwent emergent cervical decompression and fusion with corpectomy following blunt force trauma. Upon emergence, a deep extubation was performed directly to the SuperNO 2 VA nasal mask connected to a Mapleson C circuit. This is a nasal positive pressure device used to maintain upper airway patency and provide ventilatory support during emergence. While in the intensive care unit, the patient was weaned to nasal cannula. However, mental status remained poor; and upper airway obstruction ensued leading to hypoxemic respiratory insufficiency, as shown by arterial blood gas. The SuperNO 2 VA was replaced with normalization of respiratory function and blood gas analysis. After 14 hours, including the use of SuperNO 2 VA during transport to and use inside the computed tomography scanner, the patient’s mental status recovered and ventilatory support was downgraded to nasal cannula without further events. Nasal positive pressure via the SuperNO 2 VA device as described may offer an inexpensive, transportable option for providing airway and ventilatory support in high-risk patients with anticipated difficult airways.
An Online Four-Dimensional HIC×SEC-IM×MS Methodology for Proof-of-Concept Characterization of Antibody Drug Conjugates (2017)

There are currently two main techniques allowing the analytical characterization of interchain cysteine-linked antibody drug conjugates (ADCs) under native conditions, namely, hydrophobic interaction chromatography (HIC) and native mass spectrometry (MS). HIC is a chromatographic technique allowing the evaluation of drug load profile and calculation of average drug-to-antibody ratio (DAR) in quality control laboratories. Native MS offers structural insights into multiple ADC critical quality attributes, thanks to accurate mass measurement. However, both techniques can lead to misinterpretations or incomplete characterization when used as standalone methods. Online coupling of both techniques can thus potentially be of great interest, but the presence of large amounts of nonvolatile salts in HIC mobile phases makes it not easily directly compatible with native MS. Here, we present an innovative multidimensional analytical approach combining comprehensive online two-dimensional (2D)-chromatography that consists of HIC and size-exclusion chromatography (SEC), to ion mobility and mass spectrometry (IM-MS) for performing analytical characterization of ADCs under nondenaturing conditions. This setup enabled comprehensive and streamlined characterization of both native and forced degraded ADC samples. The proposed 4D methodology might be more generally adapted for online all-in-one HIC×SEC-IM×MS analysis of single proteins or analysis of protein complexes in nondenaturing conditions.
Hide and Seek -- Preserving Location Privacy and Utility in the Remote Identification of Unmanned Aerial Vehicles (2022)

Due to the frequent unauthorized access by commercial drones to Critical Infrastructures (CIs) such as airports and oil refineries, the US-based Federal Avionics Administration (FAA) recently published a new specification, namely RemoteID. The aforementioned rule mandates that all Unmanned Aerial Vehicles (UAVs) have to broadcast information about their identity and location wirelessly to allow for immediate invasion attribution. However, the enforcement of such a rule poses severe concerns on UAV operators, especially in terms of location privacy and tracking threats, to name a few. Indeed, by simply eavesdropping on the wireless channel, an adversary could know the precise location of the UAV and track it, as well as obtaining sensitive information on path source and destination of the UAV. In this paper, we investigate the trade-off between location privacy and data utility that can be provided to UAVs when obfuscating the broadcasted location through differential privacy techniques. Leveraging the concept of Geo-Indistinguishability (Geo-Ind), already adopted in the context of Location-Based Services (LBS), we show that it is possible to enhance the privacy of the UAVs without preventing CI operators to timely detect unauthorized invasions. In particular, our experiments showed that when the location of an UAV is obfuscated with an average distance of 1.959 km, a carefully designed UAV detection system can detect 97.9% of invasions, with an average detection delay of 303.97 msec. The UAVs have to trade-off such enhanced location privacy with a non-negligible probability of false positives, i.e., being detected as invading while not really invading the no-fly zone. UAVs and CI operators can solve such ambiguous situations later on through the help of the FAA, being this latter the only one that can unveil the actual location of the UAV.
Solving noisy linear operator equations by Gaussian processes: application to ordinary and partial differential equations (2003)

We formulate the problem of solving stochastic linear operator equations in a Bayesian Ganssian process (GP) framework. The solution is obtained in the spirit of a collocation method based on noisy evaluations of the target function at randomly drawn or deliberately chosen points. Prior knowledge about the solution is encoded by the covariance kernel of the GP. As in GP regression, analytical expressions for the mean and variance of the estimated target function are obtained, from which the solution of the operator equation follows by a manipulation of the kernel. Linear initial and boundary value constraints can be enforced by embedding the non-parametric model in a form that automatically satisfies the boundary conditions. The method is illustrated on a noisy linear first-order ordinary differential equation with initial condition and on a noisy second-order partial differential equation with Dirichlet boundary conditions. 1.
Use of ground-penetrating radar to study tree roots in the southeastern United States (2001)

The objectives of our study were to assess the feasibility of using ground-penetrating radar (GPR) to study roots over a broad range of soil conditions in the southeastern United States. Study sites were located in the Southern Piedmont, Carolina Sandhills and Atlantic Coast Flatwoods. At each site, we tested for selection of the appropriate antenna (400 MHz versus 1.5 GHz), determined the ability of GPR to resolve roots and buried organic debris, assessed root size, estimated root biomass, and gauged the practicality of using GPR. Resolution of roots was best in sandy, excessively drained soils, whereas soils with high soil water and clay contents seriously degraded resolution and observation depth. In the Carolina Sandhills, 16 1 x 1-m plots were scanned with the 1.5 GHz antenna using overlapping grids. Plots were subsequently excavated, larger roots (> 0.5 cm diameter) sketched on graph paper before removal, and all roots oven-dried, classified by size and weighed. Roots as small as 0.5 cm in diameter were detected with GPR. We were able to size roots (0.5 to 6.5 cm in diameter) that were oriented perpendicular to the radar sweep (r(2) = 0.81, P = 0.0004). Use of image analysis software to relate the magnitude of radar parabolas to actual root biomass resulted in significant correlations (r(2) = 0.55, P = 0.0274). Orientation and geometry of the reflective surface seemed to have a greater influence on parabola dimensions than did root size. We conclude that the utility of current GPR technology for estimating root biomass is site-specific, and that GPR is ineffective in soils with high clay or water content and at sites with rough terrain (most forests). Under particular soil and site conditions, GPR appears to be useful for augmenting traditional biomass sampling.
A technology mapping method based on perfect and semi-perfect matchings (1991)

Article Free Access Share on A technology mapping method based on perfect and semi-perfect matchings Authors: M. Crastes Institut National Polytechnique de Grenoble/CSI, 46 Av. F. Viallet 38031 GRENOBLE Cedex, France Institut National Polytechnique de Grenoble/CSI, 46 Av. F. Viallet 38031 GRENOBLE Cedex, FranceView Profile , K. Sakouti Institut National Polytechnique de Grenoble/CSI, 46 Av. F. Viallet 38031 GRENOBLE Cedex, France Institut National Polytechnique de Grenoble/CSI, 46 Av. F. Viallet 38031 GRENOBLE Cedex, FranceView Profile , G. Saucier Institut National Polytechnique de Grenoble/CSI, 46 Av. F. Viallet 38031 GRENOBLE Cedex, France Institut National Polytechnique de Grenoble/CSI, 46 Av. F. Viallet 38031 GRENOBLE Cedex, FranceView Profile Authors Info & Claims DAC '91: Proceedings of the 28th ACM/IEEE Design Automation ConferenceJune 1991 Pages 93–98https://doi.org/10.1145/127601.127634Published:01 June 1991Publication History 8citation165DownloadsMetricsTotal Citations8Total Downloads165Last 12 Months7Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Photothermal fabrication of microstructures in transparent low-melting media doped with rare earth ions as a light absorber (2006)

Microstructures were fabricated by a photothermal process in a low-melting organic-inorganic hybrid material of tin silicophosphate doped with Nd3+ ion as a light absorber. The negative refractive index change of the order of 10−3 was photothermally induced inside the low-melting glass with a spatial resolution ranging from 10to100μm using a 514.5nm emission from an Ar+ laser of less than 30mW as the excitation source. The volume expansion due to the photogenerated heat at the laser focus is found to be responsible for the photothermally induced negative photorefractive index change.
Oseltamivir Resistance in Adult Oncology and Hematology Patients Infected with Pandemic (H1N1) 2009 Virus, Australia (2010)

We describe laboratory-confirmed influenza A pandemic (H1N1) 2009 in 17 hospitalized recipients of a hematopoietic stem cell transplant (HSCT) (8 allogeneic) and in 15 patients with malignancy treated at 6 Australian tertiary centers during winter 2009. Ten (31.3%) patients were admitted to intensive care, and 9 of them were HSCT recipients. All recipients of allogeneic HSCT with infection <100 days posttransplantation or severe graft-versus-host disease were admitted to an intensive care unit. In-hospital mortality rate was 21.9% (7/32). The H275Y neuraminidase mutation, which confers oseltamivir resistance developed in 4 of 7 patients with PCR positive for influenza after > or = 4 days of oseltamivir therapy. Three of these 4 patients were critically ill. Oseltamivir resistance in 4 (13.3%) of 30 patients who were administered oseltamivir highlights the need for ongoing surveillance of such resistance and further research on optimal antiviral therapy in the immunocompromised.
Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus (2007)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
‘Gladiator’: A new potato cultivar with high resistance to potato cyst nematode and powdery scab suitable for french fries and fresh market (1995)

Abstract ‘Gladiator’ is a new maincrop potato (Solanum tuberosum L.) cultivar with resistance to both potato cyst nematode species (Globodera rostochiensis and G. pallida) and powdery scab (Spongospora subterranea). It has long oval, block‐shaped tubers suitable for french fry manufacture when mature and for fresh market when still immature.
Comparison of Corneal Shape Changes and Aberrations Induced By FS-LASIK and SMILE for Myopia (2015)

SMILE and FS-LASIK produced distinct changes in anterior corneal shape evident in different postoperative corneal curvatures and power measurements between the two groups. Postoperative HOAs were much lower after SMILE as compared to FS-LASIK.
A practical approach to polar codes (2011)

In this paper, we study polar codes from a practical point of view. In particular, we study concatenated polar codes and rate-compatible polar codes. First, we propose a concatenation scheme including polar codes and Low-Density Parity-Check (LDPC) codes. We will show that our proposed scheme outperforms conventional concatenation schemes formed by LDPC and Reed-Solomon (RS) codes. We then study two rate-compatible coding schemes using polar codes. We will see that polar codes can be designed as universally capacity achieving rate-compatible codes over a set of physically degraded channels. We also study the effect of puncturing on polar codes to design rate-compatible codes.
New approaches to insulin resistance in polycystic ovarian syndrome (1998)

The aetiology of the polycystic ovarian syndrome together with new advances in the molecular genetics and possible candidate genes for the inheritance of the syndrome is discussed. The possible role of leptin in the obesity of polycystic ovarian syndrome is reviewed. Hyperinsulinaemia acts not only as the trigger for hyperandrogenaemia and infertility, but also by stimulating plasminogen activator inhibitor type 1; hyperinsulinaemia may also promote atherogenesis in polycystic ovarian syndrome. The long-term effects of the metabolic derangements accompanying hyperinsulinaemia are reviewed. Special emphasis is placed on the use of novel insulin sensitizers such as troglitazone which promise new treatment opportunities in polycystic ovarian syndrome for both fertility and long-term disease prevention.