gebhart/patrepeval huggingface dataset:
Transcripts for cysteine-rich secretory protein-1 (CRISP-1; DE/AEG) and the novel related CRISP-3 are expressed under androgen control in the mouse salivary gland. (1993)

Expression of the gene for cysteine-rich secretory protein-1 (CRISP-1), the counterpart of the rat sperm-coating protein DE/AEG, was evidenced in male mouse salivary gland by both isolation of the corresponding cDNA clone and RNA blot analysis. In addition, the cDNA coding for the new related CRISP-3, which shares 77% amino acid identity with CRISP-1, was isolated from a salivary gland cDNA library. The activity of CRISP-1 and -3 genes in mouse salivary gland is strongly androgen dependent, as seen in castrated males; also, no CRISP-1 and only weak CRISP-3 expression was detected in female salivary gland. A variety of tissues were tested for the presence of CRISP-3 transcripts, but specific signals were only found in salivary gland. The results of genomic DNA blot analysis are compatible with the existence of single discrete genes for CRISP-1 and CRISP-3.
Thermodynamics and phase equilibria in the system Cu2O CuO ()Ga2O3 (1976)

The standard Gibbs free energies of formation of CuAlO2 and CuAl2O4 were determined in the range 700° to 1100°C, using emf measurements on the galvanic cells (1) Pt,CuO +] Cu2O/CaO-ZrO2/O2,Pt; (2) Pt,Cu +] CuAlO2+] Al2O3/CaO-ZrO2/ Cu +] Cu2O,Pt; and (3) Pt,CuAl2O4+] CuAlO2+]Al2O3/CaO-ZrO2/O2,Pt. The results are compared with published information on the stability of these compounds. The entropy of transformation of CuO from tenorite to the rock-salt structure is evaluated from the present results and from earlier studies on the entropy of formation of spinels from oxides of the rock-salt and corundum structures. The temperatures corresponding to 3-phase equilibria in the system Cu2O-CuO-Al2O3 at specified O2 pressures calculated from the present results are discussed in reference to available phase diagrams.
Use of a Microstructured Mixer for Reaction Kinetics of Thermal Cracking (2013)

A microstructured mixer was used to construct an isothermal continuous flow reactor with application to the study of vapor phase cracking kinetics. The reactor was able to heat up the reactant to the reaction temperature in a few milliseconds. The heat transfer performance of the microstructured mixer was investigated by direct measurement of the fluid temperature along the reactor. The performance of the reactor for kinetic studies was tested by investigation of the rate of pyrolysis of n-hexadecane. At temperature range of 600–750 °C, atmospheric pressure and mean residence time of 110–170 ms, the activation energy and pre-exponential factor in Arrhenius equation for overall first order thermal cracking reaction were calculated as 235 kJ/mol and 1.1 × 1013 s–1, respectively.
Hemodialysis in Patients Requiring 131I Treatment for Thyroid Carcinoma (2013)

We conclude that a successful reduction of radioactivity, without dispersing its therapeutic efficacy, can be obtained with daily hemodialysis with a CRRT machine in patients in isolation treated with 131I. A therapeutic model is proposed.
An Oxygen Reduction Study of Graphene-Based Nanomaterials of Different Origin (2016)

The aim of this study is to compare the electrochemical behaviour of graphene-based materials of different origin, e.g., commercially available graphene nanosheets from two producers and reduced graphene oxide (rGO) towards the oxygen reduction reaction (ORR) using linear sweep voltammetry, rotating disc electrode and rotating ring-disc electrode methods. We also investigate the effect of catalyst ink preparation using two different solvents (2-propanol containing OH− ionomer or N,N-dimethylformamide) on the ORR. The graphene-based materials are characterised by scanning electron microscopy, transmission electron microscopy, Raman spectroscopy and X-ray photoelectron spectroscopy. Clearly, the catalytic effect depends on the origin of graphene material and, interestingly, the electrocatalytic activity of the catalyst material for ORR is lower when using the OH− ionomer in electrode modification. The graphene electrodes fabricated with commercial graphene show better ORR performance than rGO in alkaline solution.
A Chemometric Tool to Monitor and Predict Cell Viability in Filamentous Fungi Bioprocesses Using UV Chromatogram Fingerprints (2020)

Monitoring process variables in bioprocesses with complex expression systems, such as filamentous fungi, requires a vast number of offline methods or sophisticated inline sensors. In this respect, cell viability is a crucial process variable determining the overall process performance. Thus, fast and precise tools for identification of key process deviations or transitions are needed. However, such reliable monitoring tools are still scarce to date or require sophisticated equipment. In this study, we used the commonly available size exclusion chromatography (SEC) HPLC technique to capture impurity release information in Penicillium chrysogenum bioprocesses. We exploited the impurity release information contained in UV chromatograms as fingerprints for development of principal component analysis (PCA) models to descriptively analyze the process trends. Prediction models using well established approaches, such as partial least squares (PLS), orthogonal PLS (OPLS) and principal component regression (PCR), were made to predict the viability with model accuracies of 90% or higher. Furthermore, we demonstrated the platform applicability of our method by monitoring viability in a Trichoderma reesei process for cellulase production. We are convinced that this method will not only facilitate monitoring viability of complex bioprocesses but could also be used for enhanced process control with hybrid models in the future.
Interferon α2 recombinant and epidermal growth factor modulate proliferation and hypusine synthesis in human epidermoid cancer KB cells (1997)

We previously found that interferon alpha2 recombinant (IFNalpha) increases the expression of epidermal growth factor receptor (EGF-R) in the human epidermoid cancer KB cell line. Here we report the effects of IFNalpha and epidermal growth factor (EGF) on KB cell cycle kinetics. IFNalpha (1000 i.u./ml) for 48 h decreased the S-phase fraction and diminished the expression of Ki67 and proliferating cell nuclear antigen on KB cells. Incubation of IFNalpha-treated KB cells with 10 nM EGF for 12 h reversed these effects. We then studied several biochemical markers of cell proliferation. Ornithine decarboxylase activity was decreased to about one-tenth by IFNalpha and partly restored by EGF. Hypusine is contained only in eukaryotic initiation factor 5A and its levels are correlated with cell proliferation. IFNalpha decreased hypusine synthesis by 75%; exposure of cells to EGF for 12 h restored hypusine synthesis almost completely. We also studied the effects of IFNalpha on the cytotoxicity of the recombinant toxin TP40, which inhibits elongation factor 2 through EGF-R binding and internalization. IFNalpha greatly enhanced the TP40-induced inhibition of protein synthesis in KB cells. In conclusion, IFNalpha, which affects protein synthesis machinery and increases EGF-R expression, enhances the tumoricidal activity of TP40 and hence could be useful in the setting of anti-cancer therapy.
On demand multicast routing with unidirectional links (2005)

In wireless ad-hoc networks, unidirectional links occur for several reasons: nonuniform transmit power, nonuniform background noise, and external interference. Several researchers have addressed unidirectional links and the associated unidirectional routing problem. The main focus has been so far on unicast routing; the consensus is that unidirectional links should be detected and avoided. In this paper, we consider the multicast case and derive a different conclusion: namely, it pays to exploit unidirectional links rather then avoid them. To prove the point, we select a popular ad hoc multicast protocol, on-demand multicast routing protocol (ODMRP) and introduce a slightly modified version, ODMRP-ASYM, that can handle unidirectional links. Specifically, ODMRP-ASYM reroutes the join reply packet when a unidirectional link is detected on the join query path. The option is invoked only when a unidirectional link is detected. The main advantages are: control overhead comparable with ODMRP even in highly asymmetric topologies; virtually no performance degradation in the presence of unidirectional links (while ODMRP typically suffers up to 15% drop in delivery performance); 2-connectivity maintenance even if no bidirectional path exists between sender and receiver (in this case, unidirectional link avoidance strategies fail). Extensive simulation experiments demonstrate ODMRP-ASYM robustness to unidirectional links and superiority over conventional ODMRP.
Erratum: “X-ray photoelectron spectroscopy study of irradiation-induced amorphization of Gd2Ti2O7” [Appl. Phy. Lett. 79, 1989 (2001)] (2002)

The second sentence on p. 1990: ''A carbon layer was deposited onto the surface of the sample holder in order to calibrate the binding energy shifts resulting from surface charging effects,'' should be changed to the following: ''The C 1s photoelectron line (E b 284.6 eV) was used to calibrate the binding energies of the photoelectron.'' a
Early–late heterobimetallic Rh–Ti and Rh–Zr complexes via addition of early metal chlorides to mono- and divalent rhodium (2011)

Addition of TiCl(4) or ZrCl(4) to (PNP)Rh(CH(2)==CH(t)Bu) (1) rapidly gives complexes (PNP)Rh(MCl(3))(Cl) (M = Ti, 2; Zr, 3) in 75-77% yield (PNP = (4-Me-2-((i)Pr(2)P)-C(6)H(3))(2)N). Compound 2 can also be synthesized via a reaction of (PNP)RhCl with TiCl(3) or of (PNP)TiCl(3) with 1/2 [(cod)RhCl](2).
Spiking and LFP activity in PRR during symbolically instructed reaches (2011)

The spiking activity in the parietal reach region (PRR) represents the spatial goal of an impending reach when the reach is directed toward or away from a visual object. The local field potentials (LFPs) in this region also represent the reach goal when the reach is directed to a visual object. Thus PRR is a candidate area for reading out a patient's intended reach goals for neural prosthetic applications. For natural behaviors, reach goals are not always based on the location of a visual object, e.g., playing the piano following sheet music or moving following verbal directions. So far it has not been directly tested whether and how PRR represents reach goals in such cognitive, nonlocational conditions, and knowing the encoding properties in various task conditions would help in designing a reach goal decoder for prosthetic applications. To address this issue, we examined the macaque PRR under two reach conditions: reach goal determined by the stimulus location (direct) or shape (symbolic). For the same goal, the spiking activity near reach onset was indistinguishable between the two tasks, and thus a reach goal decoder trained with spiking activity in one task performed perfectly in the other. In contrast, the LFP activity at 20-40 Hz showed small but significantly enhanced reach goal tuning in the symbolic task, but its spatial preference remained the same. Consequently, a decoder trained with LFP activity performed worse in the other task than in the same task. These results suggest that LFP decoders in PRR should take into account the task context (e.g., locational vs. nonlocational) to be accurate, while spike decoders can robustly provide reach goal information regardless of the task context in various prosthetic applications.
Optomechanical switching of adsorption configurations of polar organic molecules by UV radiation pressure (2021)

Using photoemission spectroscopy (PES), we have systematically investigated the behavior of polar organic molecule, chloroaluminum phthalocyanine (ClAlPc), adsorbed in the Cl-down configuration on the Ag(111) substrate at low temperature - 195 °C under UV irradiation with a range of different photon fluxes. Judging from the evolution of photoemission spectral line shapes of molecular energy states, we discovered that the Cl atoms are so robustly anchored at Ag(111) that the impinging photons cannot flip the ClAlPc molecules, but instead they crouch them down due to radiation pressure; we observe that the phthalocyanine (Pc) lobes bend down to interact with Ag atoms on the substrate and induce charge transfer from them. As photon flux is increased, radiation pressure on the Pc plane initiates tunneling of the Cl atom through the molecular plane to turn the adsorption configuration of ClAlPc from Cl-down to an upheld Cl-up configuration, elucidating an optomechanical way of manipulating the dipole direction of polar molecules. Finally, work function measurements provide a distinct signature of the resulting upheld Cl-up configuration as it leads to a large increase in vacuum level (VL), ~ 0.4 eV higher than that of a typical flat-on Cl-up configuration driven by thermal annealing.
Georeferencing of airborne laser altimeter measurements (1996)

Abstract The primary purpose of airborne laser altimetry is to determine the ellipsoidal or geoidal coordinates of a series of points on the surface of the Earth. An aircraft that is instrumented with a laser altimeter, an inertial navigation system, and a Global Positioning System (GPS) receiver provides the following data: (1) laser range to the Earth's surface, (2) measurement platform spatial location and orientation, and (3) aircraft kinematic trajectory in ellipsoidal coordinates. These data are sufficient to determine (georeference) the three dimensional coordinates of the points where the beam from a pulsed laser intersects the Earth. We develop the exact equations necessary to georeference the laser points. We also discuss calibrating the laser pulse timing, laser positioning and alignment relative to the local-level reference frame, correcting atmospheric refraction effects on the laser pulse, and time synchronizing the various data streams. We use a laser altimeter mission flown over Lake Crowley in California to demonstrate our methods. For seven passes over the lake, our heights agreed with a local tide gauge at the Lake Crowley dam to better than 10 cm with standard deviations ranging from 1-4 cm. The horizontal accuracy of the georeferenced points is still problematic; we have no three-dimensional control points that the laser has hit. Geometrical considerations indicate that the measured horizontal location of the laser footprint is within two metres of the true location when the aircraft altitude is less than one kilometre above the local surface.
What Will the Future of UAV Cellular Communications Be? A Flight from 5G to 6G (2021)

What will the future of UAV cellular communications be? In this tutorial article, we address such a compelling yet difficult question by embarking on a journey from 5G to 6G and sharing a large number of realistic case studies supported by original results. We start by overviewing the status quo on UAV communications from an industrial standpoint, providing fresh updates from the 3GPP and detailing new 5G NR features in support of aerial devices. We then show the potential and the limitations of such features. In particular, we demonstrate how sub-6 GHz massive MIMO can successfully tackle cell selection and interference challenges, we showcase encouraging mmWave coverage evaluations in both urban and suburban/rural settings, and we examine the peculiarities of direct device-to-device communications in the sky. Moving on, we sneak a peek at next-generation UAV communications, listing some of the use cases envisioned for the 2030s. We identify the most promising 6G enablers for UAV communication, those expected to take the performance and reliability to the next level. For each of these disruptive new paradigms (non-terrestrial networks, cell-free architectures, artificial intelligence, reconfigurable intelligent surfaces, and THz communications), we gauge the prospective benefits for UAVs and discuss the main technological hurdles that stand in the way. All along, we distil our numerous findings into essential takeaways, and we identify key open problems worthy of further study.
Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. (1993)

Immunosuppressants FK506 and cyclosporin A inhibit neurotoxicity of N-methyl-D-aspartate in primary cortical cultures, while having no effect on quisqualate- and kainate-mediated neurotoxicity. Rapamycin completely reverses the neuroprotective effect of FK506. Both FK506 and cyclosporin A inhibit NMDA-elicited/nitric oxide-mediated increases in cGMP levels in cortical cultures. FK506 has no effect on sodium nitroprusside-induced increases in cGMP. In a stably transfected human kidney 293 cell line overexpressing the gene encoding nitric oxide synthase [L-arginine, NADPH:oxygen oxidoreductase (nitric oxide-forming), EC 1.14.13.39], FK506 inhibits the calcium ionophore A23187, stimulated increases in nitrite (a breakdown product of nitric oxide), and potentiates phorbol ester-mediated inhibition of nitrite formation. FK506-mediated inhibition of nitric oxide formation is completely reversed by rapamycin. Calcineurin dephosphorylates protein kinase C-mediated phosphorylation of nitric oxide synthase. FK506 prevents the calcineurin-mediated dephosphorylation of nitric oxide synthase and thereby diminishes the enzyme's catalytic activity. These data establish nitric oxide synthase as a calcineurin substrate. Nitric oxide synthase catalytic activity is regulated by the phosphorylation state of the enzyme. Enhanced phosphorylation of nitric oxide synthase diminishes catalytic activity, and dephosphorylation (through activation of calcineurin) enhances catalytic activity. The neuroprotective effect of FK506 and cyclosporin A presumably involves the inhibition of calcineurin, preventing the dephosphorylation of nitric oxide synthase and its subsequent activation.
Secure session management with cookies (2009)

HTTP (hypertext transfer protocol) is a stateless protocol widely used in Internet World Wide Web. The idea behind a stateless design is to simplify the server conception because there is no need to dynamically allocate storage to deal with conversations in progress. If a client dies in mid-transaction, no part of the system needs to be responsible for cleaning the present state of the server. However, this forces Web developers to use alternative methods to authenticate HTTP requests and to maintain users' states. A common method for solving this problem involves sending and receiving cookies. Such mechanism implies a serious security threats. Some secure cookie solutions have been proposed in literature, but still vulnerable, particularly to replay attacks. In this paper, we propose a secure cookie mechanism that implements an intermediary reverse Proxy patterns to ensure users' sessions management and to provide the following security services: source authentication, integrity control and no-replay attacks.
Tool Support for Enterprise Architecture Management - Strengths and Weaknesses (2006)

This paper sketches the approach we have taken in an extensive survey to evaluate existing tools providing support for enterprise architecture (EA) management. From there, we outline important strengths and weaknesses of existing EA management tools discovered in the survey and suggest some approaches for improving the tool support available in this field. The tool evaluation, to which the paper refers, is built on a definition of EA management, which we operationalized via a set of scenarios, which constitute a sufficiently concrete base for making precise statements about the tool support. The paper outlines some scenarios, which are constructed to be representative for EA management, and therefore cover typical tasks. In order to ensure the representativeness of the scenarios, they were validated by ten of our industry partners. Considering the results of the evaluation, which covered nine EA management tools, we show characteristic strengths and weaknesses common to the tools. From this analysis, which e.g. covered the tools' metamodeling capabilities, the methodologies they offer to address EA management, and especially their visualization-specific capabilities, we suggest areas for further improvement regarding the software support for EA management. This is meant as a contribution to the field of EA management, which we view as not adequately addressable in practice without tool support due to the inherent complexity of this field
Gelation of Lyotropic Liquid-Crystal Phases—The Interplay between Liquid Crystalline Order and Physical Gel Formation (2019)

We present a systematical investigation of gelled lyotropic liquid crystals (LLCs). This new class of soft materials combines the anisotropy of LLCs with the mechanical stability of a physical gel. The studied LLC system consists of sodium dodecyl sulfate as a surfactant, <i>n</i>-decanol as a cosurfactant, and water as a solvent. At room temperature, four liquid crystalline phases (lamellar L<sub>α</sub>, nematic N<sub>d</sub> and N<sub>c</sub>, and hexagonal H<sub>1</sub>) are formed depending on the composition. We were successful in gelling the lyotropic lamellar phase with the low-molecular-weight organogelator 12-hydroxyoctadecanoic acid (12-HOA). The obtained gelled lamellar phase shows optical birefringence, elastic response, and no macroscopic flow. However, we were not able to obtain gels with hexagonal or nematic structure. These findings can be explained twofold. When gelling the hexagonal phase, the long-range hexagonal order was destroyed and an isotropic gel was formed. The reason might be the incompatibility between the gel fiber network and the two-dimensional long-range translational order of the cylindrical micelles in the hexagonal phase. Otherwise, the lyotropic nematic phase was transformed into an anisotropic gel with the lamellar structure during gelation. Evidently, the addition of the gelator 12-HOA to the lyotropic system considerably widens the lamellar regime because the integration of the surface-active 12-HOA gelator molecules into the nematic micelles flattens out the micelle curvature. We further investigated the successfully gelated L<sub>α</sub> phase to examine the impacts of the gel network and the remaining monomeric gelator on both the structure and properties of the gelled lamellar phase. Small-angle X-ray scattering results showed an arrested lamellar layer spacing in the gelled state, which indicates a higher translational order for the gelled lamellar phases in comparison with their gelator-free counterparts.
Cell harvesting method influences results of apoptosis analysis by annexin V staining. (2013)

To avoid substantial experimental bias caused by membrane damage, we recommend pre-testing of different harvesting methods before performing apoptosis analysis.
Coherent coupling of diode lasers by phase conjugation (1986)

We report experimental demonstrations of the use of a photorefractive barium titanate ring passive phase conjugate mirror in the coherent coupling of two GaAlAs diode lasers. By cooling the crystal towards its tetragonal to orthorhombic phase transition, we were also able to achieve infrared photorefractive phase conjugation with gain.