gebhart/patrepeval huggingface dataset:
Running Real-Time Engine Model Simulation with Hardware-in-the-Loop for Diesel Engine Development (2005)

&lt;div class="htmlview paragraph"&gt;The paper reports the design of a model and HIL system produced to support the development and testing of Electronic Control Unit/Engine Management System (ECU/EMS) software for a V6 turbo-charged automotive diesel engine. The engine model, developed in Simulink, is compiled to execute on a dSpace platform and interacts with the ECU/EMS module in real time. The main features of the engine model are outlined. The configuration of the model and HIL components are described, and the performance of the system is illustrated and discussed. Practical decisions on the inclusion of real or virtual sensors and actuators, and other implementation issues, are explained. Recent and potential future applications of the system are described.&lt;/div&gt;
Equilibrium Pricing in Incomplete Markets Under Translation Invariant Preferences (2015)

We propose a general discrete-time framework for deriving equilibrium prices of financial securities. It allows for heterogeneous agents, unspanned random endowments, and convex trading constraints. We give a dual characterization of equilibria and provide general results on their existence and uniqueness. In the special case where all agents have preferences of the same type and in equilibrium, all random endowments are replicable by trading in the financial market, we show that a one-fund theorem holds and give an explicit expression for the equilibrium pricing kernel.
In vitro alteration of physiological parameters do not hamper the growth of human multipotent vascular wall-mesenchymal stem cells (2015)

AAA-MSCs survive to extremely adverse culture conditions, keeping their morphology and stemness features. Besides MMP-9 role in pathological tissue remodeling, this protease may be related to MSC survival. Future studies on MSCs derived from other tissues will be necessary to refine our culture protocol, which can represent an empirical method to demonstrate MSC stemness, with potential implications for their clinical use.
High-resolution visualization of pial surface vessels by flattened whole mount staining (2023)

Understanding development of the cerebral vasculature is essential for the central nervous system (CNS) research and therapeutic developments. Here, we developed a simple, convenient, and fast method-the flattened cortex whole mount (FCWM) technique-for imaging of pial cerebral vessels. FCWM involves dissection of the whole cerebral cortex followed by flattening, sectioning and application of CLARITY technology. Compared to conventional methods, FCWM offers several advantages including (1) high-resolution visualization of the whole cortex pial surface vessel structures and distributions; (2) precise localization of a particular blood vessel, allowing observations of a desired blood vessel during normal development or in disease settings; (3) compatibility with confocal imaging. Application of FCWM for examination of cerebral vasculature during postnatal development or in stroke settings allowed us to demonstrate that cerebral blood vessels manifest type-specific maturation and remodeling which are linked to the rate of endothelial proliferation.
Retrieval of Scientific and Technological Resources for Experts and Scholars (2022)

Institutions of higher learning, research institutes and other scientific research units have abundant scientific and technological resources of experts and scholars, and these talents with great scientific and technological innovation ability are an important force to promote industrial upgrading. The scientific and technological resources of experts and scholars are mainly composed of basic attributes and scientific research achievements. The basic attributes include information such as research interests, institutions, and educational work experience. However, due to information asymmetry and other reasons, the scientific and technological resources of experts and scholars cannot be connected with the society in a timely manner, and social needs cannot be accurately matched with experts and scholars. Therefore, it is very necessary to build an expert and scholar information database and provide relevant expert and scholar retrieval services. This paper sorts out the related research work in this field from four aspects: text relation extraction, text knowledge representation learning, text vector retrieval and visualization system.
Our Distinctive and Noble Profession (2014)

Sound and rational decision-making: we act on our skills, education, knowledge, and experience * Honesty: needed to gain and retain the
Photoinduced Decomposition of Dibenzoyldiethylgermane: A Photochemical Route to Polygermanes (2009)

Öz bulunamadı.
Specific changes in hypothalamic alpha-adrenoceptors in young spontaneously hypertensive rats. (1981)

Changes in the activity of hypothalamic and brain-stem adrenergic neurons have been reported in young spontaneously hypertensive rats (SHR) prior to the development of hypertension. We have measured central alpha- and beta-adrenoceptor concentrations in 4-week-old SHR and Wistar-Kyoto (WKY) controls by direct radioligand binding studies using [3H]prazosin (alpha 1), [3H]clonidine (alpha 2), and [125I]iodohydroxybenzlpindolol (beta). The concentration of alpha 2-adrenoceptors was significantly elevated in the hypothalamus of the SHR, 156.9 +/- 10.4 compared with WKY, 119.4 +/- 10.0 fmole/mg protein (n = 7, mean +/- SEM, p less than 0.0125). Alpha 2-adrenoceptor concentrations in both the brain stem and cerebral cortex were similar in the two groups of animals. The increase in hypothalamic adrenoceptors was specific for alpha 2-adrenoceptors, since similar concentrations of alpha 2- and beta-adrenoceptors were found in this region.
Decrease in Expression of the Master Operon of Flagellin Synthesis in a dnaA46 Mutant of Escherichia coli. (1997)

We examined the expression of the fliC, fliA and fihD genes in the dnaA46 mutant. In Northern blot analysis, the amounts of fliC, fliA, and flhD mRNA decreased in the dnaA46 mutant growing at 37 degrees C but not at 28 degrees C. The promoter activity of each gene also decreased in this mutant at 37 degrees C. The decrease in expression of the flh D gene was not related to the cAMP-catabolite activator protein (CAP) pathway. We tentatively conclude that DnaA protein is involved in the expression of the flhD gene by a mechanism independent of the cAMP-CAP pathway.
Validating SAT solvers using an independent resolution-based checker: practical implementations and other applications (2003)

As the use of SAT solvers as core engines in EDA applications grows, it becomes increasingly important to validate their correctness. In this paper, we describe the implementation of an independent resolution-based checking procedure that can check the validity of unsatisfiable claims produced by the SAT solver zchaff. We examine the practical implementation issues of such a checker and describe two implementations with different pros and cons. Experimental results show low overhead for the checking process. Our checker can work with many other modern SAT solvers with minor modifications, and it can provide information for debugging when checking fails. Finally we describe additional results that can be obtained by the validation process and briefly discuss their applications.
Safety and efficacy of autologous tumour cell vaccines as a cancer therapeutic to treat solid tumours and haematological malignancies: a meta-analysis protocol for two systematic reviews (2020)

CRD42019140187.
Radiation effects on optical fibers and amplifiers (2001)

The effects of gamma radiation on rare-earth doped optical fibers have been investigated over the range of 0.01 to 145 kilorads(Si) per hour to total doses exceeding 100 kilorads(Si). The effects of 3 to 4 MeV protons have also been investigated. The level of radiation induced damage has been found to be strongly dependent on radiation dose rate and fiber composition. The existence of dose rate dependence is explained by the process of simultaneous creation of color center defects and annihilation via thermal annealing. Through the use of a suitable kinetic analysis technique, we have determined appropriate rate constants for this process and have developed an empirical model based on our experimental results. In addition to these results, we present the effects of gamma radiation on the performance of operational high power erbium-ytterbium optical amplifiers.
Open source development tools for IMS research (2008)

The 3GPP IMS is a next generation network architecture aimed at bringing the features and rich services of the Internet to the telephony world. Traditionally telephony products are developed by large companies with access to the proprietary solutions required for PSTN products. However, the shift to a packet-switched architecture and open Internet protocols has increased the developer base to include the huge community of web-developers.Consequently there are currently several open source software projects that aim to provide proof-of-concept implementations and research tools for promoting the development and adoption of IMS technologies. This work investigates the tools created by four open source IMS projects and incorporates these tools into a practical IMS test-bed framework. Evaluations are performed that demonstrate the capabilities and limitations of these tools in providing rich services to IMS users.
A decentralized lateral-longitudinal controller for a platoon of vehicles operating on a plane (2006)

This paper studies the decentralized control of a platoon of identical vehicles which are moving on a plane, where each vehicle is assumed to have steering dynamics; each vehicle in this case is assumed to be described by a 6 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> order model and has two inputs: traction force and steering angle. Special cases such as a "side-tracking" formation with decentralized coordinated lateral-longitudinal control is studied. An example of a 10-vehicle platoon which is controlled to "sweep a field" is included to illustrate the results which can be obtained
KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation (2019)

Kaposi's sarcoma associated herpesvirus (KSHV), like all herpesviruses maintains lifelong persistence with its host genome in latently infected cells with only a small fraction of cells showing signatures of productive lytic replication. Modulation of cellular signaling pathways by KSHV-encoded latent antigens, and microRNAs, as well as some level of spontaneous reactivation are important requirements for establishment of viral-associated diseases. Hypoxia, a prominent characteristic of the microenvironment of cancers, can exert specific effects on cell cycle control, and DNA replication through HIF1α-dependent pathways. Furthermore, hypoxia can induce lytic replication of KSHV. The mechanism by which KSHV-encoded RNAs and antigens regulate cellular and viral replication in the hypoxic microenvironment has yet to be fully elucidated. We investigated replication-associated events in the isogenic background of KSHV positive and negative cells grown under normoxic or hypoxic conditions and discovered an indispensable role of KSHV for sustained cellular and viral replication, through protection of critical components of the replication machinery from degradation at different stages of the process. These include proteins involved in origin recognition, pre-initiation, initiation and elongation of replicating genomes. Our results demonstrate that KSHV-encoded LANA inhibits hypoxia-mediated degradation of these proteins to sustain continued replication of both host and KSHV DNA. The present study provides a new dimension to our understanding of the role of KSHV in survival and growth of viral infected cells growing under hypoxic conditions and suggests potential new strategies for targeted treatment of KSHV-associated cancer.
Molecular motors implicated in the axonal transport of tau and α-synuclein (2005)

Tau and α-synuclein are both proteins implicated in the pathology of neurodegenerative disease. Here we have investigated the mechanisms of axonal transport of tau and α-synuclein, because failure of axonal transport has been implicated in the development of several neurodegenerative disorders. We found that the transport of both of these proteins depend on an intact microtubule- but not actin-cytoskeleton, and that tau and α-synuclein both move at overall slow rates of transport. We used time-lapse video microscopy to obtain images of live neurons that had been transfected with plasmids expressing proteins tagged with enhanced green fluorescent protein. We found that particulate structures containing tau or α-synuclein travel rapidly when moving along axons but spend the majority of the time paused, and these structures have similar characteristics to those previously observed for neurofilaments. The motile particles containing tau or α-synuclein colocalise with the fast-transporting molecular motor kinesin-1 in neurons. Co-immunoprecipitation experiments demonstrate that tau and α-synuclein are each associated with complexes containing kinesin-1, whereas only α-synuclein appears to interact with dynein-containing complexes. In vitro glutathione S-transferase-binding assays using rat brain homogenate or recombinant protein as bait reveals a direct interaction of kinesin-1 light chains 1 and 2 with tau, but not with α-synuclein. Our findings suggest that the axonal transport of tau occurs via a mechanism utilising fast transport motors, including the kinesin family of proteins, and that α-synuclein transport in neurons may involve both kinesin and dynein motor proteins.
Interplay of the Trion Singlet and Triplet State Transitions in Magnetooptical and Time-Resolved Investigation of ZnSe/Zn(S,Se) Single Quantum Wells (2002)

Negatively charged trions are investigated for ZnSe single quantum wells embedded in ternary barriers. Polarization and excitation dependent photoluminescence measurements were performed in magnetic fields up to 11.8 T. From these measurements we are able to develop an energy-term scheme for the spin-singlet and the spin-triplet state of the trion.
Comparison of protein expression profiles between monolayer and spheroid cell culture of HT-29 cells revealed fragmentation of CK18 in three-dimensional cell culture (2002)

The use of three-dimensional cell culture models, so-called multicellular tumor spheroids, is a special approach in experimental cancer research, because spheroids are similar to in vivo tumors in structural as well as functional sense. Cells grown in spheroids exhibit alterations of cell cycle regulation, induction of apoptosis and differentiation and can acquire multidrug resistance. In this study we investigated the protein expression in human colorectal cancer cells grown in monolayer and in spheroid cultures using proteomics. Evaluation by computer-assisted image analysis revealed overexpression of three cytokeratin 18 fragments that were generated in vivo. Cytokeratin 18 has previously been described as a target for caspase-mediated cleavage during apoptosis and our results indicate that apoptosis may take place in spheroids. Other proteins upregulated in spheroids include calreticulin precursor, a rho GDP dissociation inhibitor variant, several cytokeratins and peroxiredoxin 4. Some of these proteins have already been linked to chemoresistance and apoptotic phenomena.
Monitoring SARS-CoV-2 seroprevalence over time among pregnant women admitted to delivery units: Suitability for surveillance (2023)

Women at delivery represent a highly exposed and readily accessible population for sentinel surveillance of emerging infections such as SARS-CoV-2.
멀티미디어 & HCI : 분산 멀티미디어 응용을 위한 실시간 동기화 메커니즘 (2000)

분산 멀티미디어 시스템에서는 미디어들 간에 존재하는 시간 관계성을 정확하게 표현하면서 네트워크의 가변적인 지연으로 인해 유발되는 비동기 문제를 해결할 수 있는 동기화 메카니즘이 필요하다. 본 논문에서는 실시간 분산 환경의 멀티미디어 응용을 지원하기 위해 Petri Net에 기반한 RTPN(Real-Time Petri Net) 동기화 명세 모델을 제안한다. 제안하는 모델은 미디어의 지연관계나 중요도에 의해 주요 키 미디어와 상대 키 미디어를 정의하여 다양한 미디어 객체간의 시간 관계를 유연하게 명세 한다. 그리고 점화 규칙은 비동기 허용율에 기반한 점화 함수에 의해 즉시 발생 되어 미디어 내 및 미디어간 실시간 동기화를 지원한다. 한편 프리젠테이션 레벨의 재동기를 위한 비동기 제어 알고리즘은 보다 효율적인 QoS 보장이 가능하다.
Sustainability: the capacity of smokeless biomass pyrolysis for energy production, global carbon capture and sequestration (2010)

Smokeless biomass pyrolysis for biochar and biofuel production is a possible arsenal for global carbon capture and sequestration at gigatons of carbon (GtC) scales. The United States can annually harvest over 1.3 Gt (gigaton) of dry biomass. Use of the smokeless (clean and efficient) biomass-pyrolysis technology would enable the United States to converts its 1.3 Gt of annually harvestable biomass to biochar products equivalent to 325 million tons of stable carbon plus significant amount of biofuels including syngas and bio-oils. Currently, the world could annually harvest more than 6.5 GtC y−1 of biomass. The 6.5 GtC y−1 of biomass could be converted to biochar (3.25 GtC y−1) and biofuels (with heating value equivalent to that of 6500 million barrels of crude oil). Because biochar is mostly not digestible to microorganisms, a biochar-based soil amendment could serve as a permanent carbon-sequestration agent in soils/subsoil earth layers for thousands of years. By storing 3.25 GtC y−1 of biochar (equivalent to 11.9 Gt of CO2 per year) into soil and/or underground reservoirs alone, it would offset the world's 8.67 GtC y−1 of fossil fuel CO2 emissions by about 38%. The worldwide maximum capacity for storing biochar carbon into agricultural soils (1411 million hectares) is estimated to be about 428 GtC. It may be also possible to provide a global carbon “thermostat” mechanism by creating biochar carbon energy storage reserves. This biomass-pyrolysis “carbon-negative” energy approach merits serious research and development worldwide to help provide clean energy and control global warming for a sustainable future of human civilization on Earth.
Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy (2022)

Locally advanced cancers remain therapeutically challenging to eradicate. The most successful treatments continue to combine decades old non-targeted chemotherapies with radiotherapy that unfortunately increase normal tissue damage in the irradiated field and have systemic toxicities precluding further treatment intensification. Therefore, alternative molecularly guided systemic therapies are needed to improve patient outcomes when applied with radiotherapy. In this work, we report a trimodal precision cytotoxic chemo-radio-immunotherapy paradigm using spatially targeted auristatin warheads. Tumor-directed antibodies and peptides conjugated to radiosensitizing monomethyl auristatin E (MMAE) specifically produce CD8 T cell dependent durable tumor control of irradiated tumors and immunologic memory. In combination with ionizing radiation, MMAE sculpts the tumor immune infiltrate to potentiate immune checkpoint inhibition. Here, we report therapeutic synergies of targeted cytotoxic auristatin radiosensitization to stimulate anti-tumor immune responses providing a rationale for clinical translational of auristatin antibody drug conjugates with radio-immunotherapy combinations to improve tumor control.
The ultra-wideband signal propagation (2004)

In the ultra-wideband (UWB) system the pulses are transmitted at a very low level, where the signal looks like low level noise to the other wireless system. Therefore, a good understanding of the UWB signal propagation is necessary. Moreover, UWB communications rely on an unusual wireless technology (a carrier free and huge bandwidth), so that designing of UWB system raises a number of questions. This paper describes a theoretical study of the UWB propagation and losses. This study is based on two ray model in the case of short range line of sight UWB transmission. The model takes into account both frequency dependent parameters and distance.
Super Resolution Fluorescence Microscopy and Tracking of Bacterial Flotillin (Reggie) Paralogs Provide Evidence for Defined-Sized Protein Microdomains within the Bacterial Membrane but Absence of Clusters Containing Detergent-Resistant Proteins (2016)

Biological membranes have been proposed to contain microdomains of a specific lipid composition, in which distinct groups of proteins are clustered. Flotillin-like proteins are conserved between pro-and eukaryotes, play an important function in several eukaryotic and bacterial cells, and define in vertebrates a type of so-called detergent-resistant microdomains. Using STED microscopy, we show that two bacterial flotillins, FloA and FloT, form defined assemblies with an average diameter of 85 to 110 nm in the model bacterium Bacillus subtilis. Interestingly, flotillin microdomains are of similar size in eukaryotic cells. The soluble domains of FloA form higher order oligomers of up to several hundred kDa in vitro, showing that like eukaryotic flotillins, bacterial assemblies are based in part on their ability to self-oligomerize. However, B. subtilis paralogs show significantly different diffusion rates, and consequently do not colocalize into a common microdomain. Dual colour time lapse experiments of flotillins together with other detergent-resistant proteins in bacteria show that proteins colocalize for no longer than a few hundred milliseconds, and do not move together. Our data reveal that the bacterial membrane contains defined-sized protein domains rather than functional microdomains dependent on flotillins. Based on their distinct dynamics, FloA and FloT confer spatially distinguishable activities, but do not serve as molecular scaffolds.
Synthesis and thermal stability of sodium, magnesium co-substituted hydroxyapatites (2005)

Sodium and magnesium co-substituted hydroxyapatite (Hap) and β-tricalcium phosphate mixtures were prepared through an aqueous precipitation method. Characterization results from XRD, FT-IR and thermal analysis have indicated the influence of additives (Na and Mg) on the thermal stability of the apatites. The elemental analyses have also confirmed the presence of Na+ and Mg2+ ions in the apatite structure. Calculated lattice parameters for the combined substitution of elements on the apatite structure were found to have contraction of the a-axis and expansion of the c-axis as well as of the unit cell volume with respect to that of pure Hap.