gebhart/patrepeval huggingface dataset:
An internal deletion in the cytoplasmic tail reverses the apical localization of human NGF receptor in transfected MDCK cells. (1991)

A cDNA encoding the full-length 75-kD human nerve growth factor receptor was transfected into MDCK cells and its product was found to be expressed predominantly (80%) on the apical membrane, as a result of vectorial targeting from an intracellular site. Apical hNGFR bound NGF with low affinity and internalized it inefficiently (6% of surface bound NGF per hour). Several mutant hNGFRs were analyzed, after transfection in MDCK cells, for polarized surface expression, ligand binding, and endocytosis. Deletionof juxta-membrane attachment sites for a cluster of O-linked sugars did not alter apical localization. A mutant receptor lacking the entire cytoplasmic tail (except for the five proximal amino acids) was also expressed on the apical membrane, suggesting that information for apical sorting was contained in the ectoplasmic or transmembrane domains. However, a 58 amino acid deletion in the hNGFR tail that moved a cytoplasmic tyrosine (Tyr 308) closer to the membrane into a more charged environment resulted in a basolateral distribution of the mutant receptor and reversed vectorial (basolateral) targeting. The basolateral mutant receptor also internalized 125I-NGF rapidly (90% of surface bound NGF per hour), exhibited a larger intracellular fraction and displayed a considerably shortened half-life (approximately 3 h). We suggest that hNGFR with the internal cytoplasmic deletion expresses a basolateral targeting signal, related to endocytic signals, that is dominant over apical targeting information in the ecto/transmembrane domains. These results apparently contradict a current model that postulates that basolateral targeting is a default mechanism.
EUROSENSORS 2014, the XXVIII edition of the conference series Water based PVA sacrificial ma terial for low temperature MEMS fabrication and applications on e-textiles (2014)

Abstract A sacrificial-layer approach enables the realisation of free-standing mechanical structures on textiles. This work presents a screen printable water based polyvinyl alcohol (PVA) sacrificial material, which, when printed and dried, provides a stable mechanical support for subsequent printed structural layers. The PVA support layer can be removed in water once all other processes are complete. The sacrificial paste is compatible with most textiles and is environmentally friendly due to a low release of volatile organic compounds (VOC). The process is demonstrated by fabricating a capacitively coupled cantilever on textile using screen printing. The resultant cantilever has a resonant frequency of 145 Hz that confirms the PVA sacrificial material has been entirely removed. © 2014 The Authors. Published by Elsevier Ltd. Peer-review under responsibility of the scientific committee of Eurosensors 2014. Keywords: e-textile; sacrifical material; polyvinyl alcohol (PVA); screen printing; cantilever
Field-Effect Flow Control for Microfabricated Fluidic Networks (2006)

The magnitude and direction of the electro-osmotic flow (EOF) inside a microfabricated fluid channel can be controlled by a perpendicular electric field of 1.5 megavolts per centimeter generated by a voltage of only 50 volts. A microdevice called a flowFET, with functionality comparable to that of a field-effect transistor (FET) in microelectronics, has been realized. Two flowFETs integrated with a channel junction have been used to generate opposite flows inside a single EOF-pumped channel, thus illustrating the potential of the flowFET as a controlling and switching element in microfluidic networks.
Procoagulant and prothrombotic activation of human erythrocytes by phosphatidic acid (2010)

Increased phosphatidic acid (PA) and phospholipase D (PLD) activity are frequently observed in various disease states including cancers, diabetes, sepsis, and thrombosis. Previously, PA has been regarded as just a precursor for lysophosphatidic acid (LPA) and diacylglycerol (DAG). However, increasing evidence has suggested independent biological activities of PA itself. In the present study, we demonstrated that PA can enhance thrombogenic activities in human erythrocytes through phosphatidylserine (PS) exposure in a Ca(2+)-dependent manner. In freshly isolated human erythrocytes, treatment of PA or PLD induced PS exposure. PA-induced PS exposure was not attenuated by inhibitors of phospholipase A(2) or phosphatidate phosphatase, which converts PA to LPA or DAG. An intracellular Ca(2+) increase and the resultant activation of Ca(2+)-dependent PKC-alpha appeared to underlie the PA-induced PS exposure through the activation of scramblase. A marginal decrease in flippase activity was also noted, contributing further to the maintenance of exposed PS on the outer membrane. PA-treated erythrocytes showed strong thrombogenic activities, as demonstrated by increased thrombin generation, endothelial cell adhesion, and erythrocyte aggregation. Importantly, these procoagulant activations by PA were confirmed in a rat in vivo venous thrombosis model, where PA significantly enhanced thrombus formation. In conclusion, these results suggest that PA can induce thrombogenic activities in erythrocytes through PS exposure, which can increase thrombus formation and ultimately contribute to the development of cardiovascular diseases.
Supplementary Fig Legends from Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins (2023)

Supplementary Fig Legends from Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins
Reduction of attenuation effects in 3D transrectal ultrasound images (2007)

Ultrasound (US) is one of the most used imaging modalities today as it is cheap, reliable, safe and widely available. There are a number of issues with US images in general. Besides reflections which is the basis of ultrasonic imaging, other phenomena such as diffraction, refraction, attenuation, dispersion and scattering appear when ultrasound propagates through different tissues. The generated images are therefore corrupted by false boundaries, lack of signal for surface tangential to ultrasound propagation, large amount of noise giving rise to local properties, and anisotropic sampling space complicating image processing tasks. Although 3D Transrectal US (TRUS) probes are not yet widely available, within a few years they will likely be introduced in hospitals. Therefore, the improvement of automatic segmentation from 3D TRUS images, making the process independent of human factor is desirable. We introduce an algorithm for attenuation correction, reducing enhancement/shadowing effects and average attenuation effects in 3D US images, taking into account the physical properties of US. The parameters of acquisition such as logarithmic correction are unknown, therefore no additional information is available to restore the image. As the physical properties are related to the direction of each US ray, the 3D US data set is resampled into cylindrical coordinates using a fully automatic algorithm. Enhancement and shadowing effects, as well as average attenuation effects, are then removed with a rescaling process optimizing simultaneously in and perpendicular to the US ray direction. A set of tests using anisotropic diffusion are performed to illustrate the improvement in image quality, where well defined structures are visible. The evolution of both the entropy and the contrast show that our algorithm is a suitable pre-processing step for segmentation tasks.
Nonlinear Breakup Model for a Liquid Sheet Emanating From a Pressure-Swirl Atomizer (2007)

Predictions of breakup length of a liquid sheet emanating from a pressure-swirl (simplex) fuel atomizer have been carried out by computationally modeling the two-phase flow in the atomizer coupled with a nonlinear analysis of instability of the liquid sheet. The volume-of-fluid (VOF) method has been employed to study the flow field inside the pressure-swirl atomizer. A nonlinear instability model has been developed using a perturbation expansion technique with the initial amplitude of the disturbance as the perturbation parameter to determine the sheet instability and breakup. The results for sheet thickness and velocities from the internal flow solutions are used as input in the nonlinear instability model. Computational results for internal flow are validated by comparing film thickness at exit, spray angle, and discharge coefficient with available experimental data. The predictions of breakup length show a good agreement with semiempirical correlations and available experimental measurements. The effect of elevated ambient pressure on the atomizer internal flow field and sheet breakup is investigated. A decrease in air core diameter is obtained at higher ambient pressure due to increased liquid-air momentum transport. Shorter breakup lengths are obtained at elevated air pressure. The coupled internal flow simulation and sheet instability analysis provides a comprehensive approach to modeling sheet breakup from a pressure-swirl atomizer.
Animal models of extracranial pediatric solid tumors (2012)

Animal models, including xenografts, models of metastatic invasion, syngeneic models and transgenic models, are important tools for basic research in solid pediatric tumors, while humanized animal models are useful for novel immunotherapeutical approaches. Optical and molecular imaging techniques are used for in vivo imaging and may be used in conjunction with alternative treatment approaches, including photodynamic therapy. The aim of this review is to highlight the various animal models that may be used for basic research in pediatric solid tumors.
Collagen Fiber Alignment in the Human Preauricular Dermis Before and After Rhytidectomy-A Scanning Electron Microscopy Study (1986)

The microarchitecture of collagen fibers in preauricular dermis specimens that were obtained during two-phase rhytidectomy were visualized and recorded using the scanning electron microscope. Examination of photomicrographs revealed that both spatial arrangement and degree of convolution of the collagen fibers were completely different in the specimens of the two phases. The results are interpreted in terms of the viscoelastic properties of the skin.
The Optical Stark Shift on a Two-Photon Transition in Rubidium (2018)

An atomic clock designed around the 778 nm two-photon transition in rubidium vapor has become an appealing option for future portable optical clocks. However, two-photon transitions are known to suffer from large AC Stark shifts. We present an analysis of the AC Stark shift in the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$5\mathrm{S}_{1/2}\rightarrow 5\mathrm{D}_{5/2}$</tex> two photon transition of Rb, along with an improved determination of the blackbody radiation Stark shift.
Micromechanical Optical Crossconnect With 4-&gt;tex&lt;$F$&gt;/tex&lt;Relay Imaging Optics (2004)

We describe a novel optical configuration for a microelectromechanical system (MEMS)-based beam-steering optical crossconnect. It incorporates 4-F imaging optics to relay light to the MEMS chip. This makes the system more tolerant to fiber-microlens misalignment. The use of a relay plus Fourier lens and patterned mirror removes the skew angle on the MEMS array and reduces the maximum angle for the MEMS mirror. A prototype 110 /spl times/ 110 crossconnect employing imaging optics was constructed to validate the approach. This achieved a mean fiber-to-fiber insertion loss of 2.9 dB.
Quantitative potential of Y-90 PET (2011)

601 Objectives The feasibility of yttrium-90 PET has recently been demonstrated in patients following liver tumor radioembolization with Y-90 microspheres. In addition to confirming the in-vivo microsphere distribution, PET can potentially be used to quantify the dose delivered, although this capability has not yet been confirmed. In this study we assess the quantitative accuracy of Y-90 PET which is potentially compromised by an extremely low positron fraction and intrinsic radioactivity in the detectors. Methods Y-90 phantom experiments were performed using an elliptical chest phantom that included a 6 cm spherical insert. The activity in each compartment was measured using an ionization chamber with a calibration setting that had been previously validated for Y-90 (55×10, Zimmerman 2004). The initial sphere concentration was 1287 kBq/mL and was typical of tumors following Y-90 therapy. PET data were acquired at a single bed position using a Discovery RX PET/CT scanner: LYSO; 425 keV LLD; no time-of-flight; 3D acquisition; randoms correction from singles; OSEM (2i, 21s, 7mm Gaussian); positron fraction 0.00003186 (Selwyn 2007). Six images were acquired over 2 half-lives and ROI analysis was used to compare image-derived activity concentrations with values determined by the ionization chamber. Results Coincidence count rates ranged from 61-257 cps trues and 2288-2911 cps randoms. Lu-176 in the detectors contributed 8 cps trues and 2100 cps randoms. The average number of true events recorded at each scan was 461 ± 69 kcounts. Bland-Altman analysis comparing PET and ionization chamber measurements showed a mean difference of 16.2 kBq/mL and 95% confidence intervals of +134.8 and -102.4 kBq/mL. Although image noise contributed variability between the two measurements (indicated by the 95 % limits), systematic bias was very low compared to the high activity concentrations encountered in tumors. Conclusions Despite the extremely low positron fraction of Y-90, quantitatively accurate PET images can be acquired with a conventionally calibrated, non-time-of-flight, lutetium-based PET/CT scanner
Unified Power Management Framework for Portable Media Devices (2007)

Power management is one of the key design challenges in the design of portable multimedia devices (PMD). Existing power management techniques are limited to hardware based DVFS (dynamic schemes) and do not take into account application states and many usage scenarios. In this correspondence, a new unified power management framework (UPMF) is proposed which describes a software architecture for a unified hardware and software controlled power management. The framework provides a set of rules for classifying the several devices on a PMD into device classes. Each of these device classes has a set of well-defined states based on the application state. The power management framework contains a power manager module that monitors the application and maintains the states of the devices and based on the power management strategy, controls the states of the devices. The proposed UPMF is very simple to implement and is well suited to handle power management strategies for several classes of applications. Performance of this proposed scheme for a portable media player and recorder device is also presented.
Prevalence of anxiety disorders and their comorbidity with mood and addictive disorders (1998)

Anxiety disorders, especially social and simple phobias, appear to have an early onset in adolescence with potentially severe consequences, predisposing those affected to greater vulnerability to major depression and addictive disorders.
Mycoplasma genitalium: prevalence, clinical significance, and transmission (2005)

M genitalium is associated with urethritis in both men and women and with cervicitis in women. A high concordance rate was found among sexual partners of M genitalium infected patients, indicating that the infection is sexually transmitted.
EMOTIVE Cloud (2011)

This chapter introduces Elastic Management of Tasks in Virtualized Environments (EMOTIVE), which is the Barcelona Supercomputing Center (BSC)’s IaaS open-source solution for Cloud Computing. EMOTIVE provides users with elastic fully customized virtual environments in which to execute their applications. Further, it simplifies the development of new middleware services for managing Cloud systems by supporting resource allocation and monitoring, data management, live migration, and checkpoints. These features and its facility to be extended and configured make EMOTIVE especially appropriate to support research on Cloud Computing scenarios. Offering functionality comparable to its commercial counterparts allows EMOTIME to be used on production to set up small Cloud platforms.
ChemInform Abstract: EFFECT OF CHROMYL FLUORIDE ON GRAPHITE INTERCALATION WITH FLUORIDES AND OXYFLUORIDES OF METALS FROM THE VANADIUM AND CHROMIUM FAMILIES (1983)

Abstract Graphit‐Intercalationsverbindungen der ersten Stufe mit (Oxid‐)Fluoriden von VB‐ und VIB‐Metallen ließen sich unter CrOzFz‐Atmosphäre leicht herstellen.
Optimization of DRAM sense amplifiers for the gigabit era (2002)

This paper reviews sense amplifier design challenges as DRAM densities are increased beyond a gigabit. Various proposed solutions for maintaining high performance and sensitivity, while reducing the array voltage are reviewed. Preamplification, body-effect control, V/sub t/ mismatch cancellation, and two revolutionary solutions are presented and discussed.
Don't forget increased risk of fetal growth restriction (2009)

The article on how easily coeliac disease is missed did not highlight the association between undiagnosed coeliac disease and an increased risk of fetal growth restriction.1 Fetal growth restriction is a major pregnancy complication responsible for a …
A flow cytometric method for measuring neutralization of HIV-1 subtype B and E primary isolates (2000)

Flow cytometric detection of intracellular HIV-1 p24 can be used as an endpoint assay to assess neutralization of HIV-1 subtypes B' and E primary isolates. This enumerative method has the advantage of identifying intracellular p24 in specific subsets at an early culture timepoint. It also provides an alternative quantitative endpoint for HIV neutralization assays.
Rapid modeling of animated faces from video (2001)

Abstract Generating realistic 3D human face models and facial animations has been a persistent challenge in computer graphics. We have developed a system that constructs textured 3Dface models from videos with minimal user interaction. Our system takes images andvideo sequences of a face with an ordinary video camera. After five manual clicks ontwo images to tell the system where the eye corners, nose top and mouth corners are, thesystem automatically generates a realistic looking 3D human head model and the constructed model can be animated immediately. A user with a PC and an ordinary camera can use our system to generate his/her face model in a few minutes. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Unified Data Model of Urban Air Pollution Dispersion and 3D Spatial City Model: Groundwork Assessment towards Sustainable Urban Development for Malaysia (2013)

Understanding the behavior of urban air pollution is important en route for sustainable urban development (SUD). Malaysia is on its mission to be a developed country by year 2020 comprehends dealing with air pollution is one of the indicators headed towards it. At present monitoring and managing air pollution in urban areas encompasses sophisticated air quality modeling and data acquisition. However, rapid developments in major cities cause difficulties in acquiring the city geometries. The existing method in acquiring city geometries data via ground or space measurement inspection such as field survey, photogrammetry, laser scanning, remote sensing or using architectural plans appears not to be practical because of its cost and efforts. Moreover, air monitoring stations deployed are intended for regional to global scale model whereby it is not accurate for urban areas with typical resolution of less than 2 km. Furthermore in urban areas, the pollutant dispersion movements are trapped between buildings initiating it to move vertically causing visualization complications which imply the limitations of existing visualization scheme that is based on two-dimensional (2D) framework. Therefore this paper aims is to perform groundwork assessment and discuss on the current scenario in Malaysia in the aspect of current policies towards SUD, air quality monitoring stations, scale model and detail discussion on air pollution dispersion model used called the Operational Street Pollution Model (OSPM). This research proposed the implementation of three-dimensional (3D) spatial city model as a new physical data input for OSPM. The five Level of Details (LOD) of 3D spatial city model shows the scale applicability for the dispersion model implementtation. Subsequently 3D spatial city model data commonly available on the web, by having a unified data model shows the advantages in easy data acquisition, 3D visualization of air pollution dispersion and improves visual analysis of air quality monitoring in urban areas.
Dosing angiotensin II blockers—beyond blood pressure (1999)

Key words: angiotensin II; TGF-b; fibrosis inhibitors progressively lose their antiproteinuric superiority compared with other antihypertensive agents when blood pressure is reduced progressively to ever lower values within the range of normotension; Antihypertensive treatment and progression ofthis is true both for the antiproteinuric action [8] and for renal events ( E. Lewis, personal communication).
Medical-surgical nursing : clinical management for continuity of care (1997)

The edition of this landmark medical-surgical nursing text retains the comprehensiveness, authority, and in-depth pathophysiology coverage that made earlier editions so effective. However, the 5th Edition features a significant new emphasis on the continuum of medical-surgical nursing--from on-site care through emergency room, intensive, acute, subacute, general, and community care settings. New chapters address essential issues such as aging, acute care, home health care, ambulatory care, and diagnostic testing. Ancillaries include a Study Guide, ExaMaster, Pocket Companion, Instructor's Manual, Test Manual, and Transparencies.
Phase transition asymptotics for random walks on a stationary random potential (2005)

We describe a universal transition mechanism characterizing the passage to an annealed behavior and to a regime where the fluctuations about this behavior are Gaussian, for the long time asymptotics of the empirical average of the expected value of the number of random walks which branch and annihilate on Z d, with stationary random rates. The random walks are independent, continuous time rate 2dκ, simple, symmetric, with κ ≥ 0. A random walk at x ∈ Z d, binary branches at rate v+(x), and annihilates at rate v−(x). The random environment w has coordinates w(x) = (v−(x), v+(x)) which are i.i.d. We identify a natural way to describe the annealed-Gaussian transition mechanism under mild conditions on the rates. Indeed, we introduce the exponents
Enantioselective Hydrogenation of Isomeric β‐Acylamido β‐Alkylacrylates with Chiral Rh(I) Complexes—Comparison of Phosphine Ligands and Substrates. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.