gebhart/patrepeval huggingface dataset:
FPGA Implementation of High Speed FIR Filters Using Add and Shift Method (2006)

We present a method for implementing high speed finite impulse response (FIR) filters using just registered adders and hardwired shifts. We extensively use a modified common subexpression elimination algorithm to reduce the number of adders. We target our optimizations to Xilinx Virtex II devices where we compare our implementations with those produced by Xilinx CoregenTM using Distributed Arithmetic. We observe up to 50% reduction in the number of slices and up to 75% reduction in the number of LUTs for fully parallel implementations. We also observed up to 50% reduction in the total dynamic power consumption of the filters. Our designs perform significantly faster than the MAC filters, which use embedded multipliers.
Location of ligand-binding sites on the nicotinic acetylcholine receptor alpha-subunit. (1986)

The portions of the Torpedo californica nicotinic acetylcholine receptor (AChR) alpha-subunit that contribute to the allosteric antagonist-binding site and to the agonist-binding site have been localized by affinity labeling and proteolytic mapping. [3H]Meproadifen mustard was employed as an affinity label for the allosteric antagonist-binding site and [3H]tubocurare as a photoaffinity label for the agonist-binding site. Both labels were found in a 20-kDa proteolytic fragment generated from the AChR alpha-subunit by Staphylococcus aureus V8 protease. This 20-kDa peptide also contains the 3H-labeled 4-(N-maleimido)-alpha-benzyltrimethylammonium iodide-reactive site and binds 125I-alpha-bungarotoxin. N-terminal sequencing established that the 20-kDa fragment began at Ser-173 of the alpha-subunit. Fluorescein isothiocyanate-conjugated concanavalin A could be bound to the second of the two major V8 cleavage products, an 18-kDa peptide. This peptide was also sensitive to treatment with endo-beta-N-acetyl-glucosaminidase H, consistent with the presence of N-linked carbohydrate on this fragment. The N terminus of this peptide was found to be Val-46 of the alpha-subunit sequence. Experiments designed to map disulfide bonds within the AChR alpha-subunit indicate that no bonds exist between the 18-kDa fragment (containing Cys-128 and Cys-142) and the 20-kDa fragment (containing Cys-192, Cys-193, and Cys-222). These results establish that the 20-kDa fragment contributes to both the acetylcholine and the allosteric antagonist-binding sites, whereas there is no evidence that the 18-kDa fragment is part of either site.
Shift Reference Manual - eScholarship (1997)

This document is a reference manual for SHIFT, a description language for dynamic networks of hybrid systems. This model offers the proper level of abstraction for describing complex applications such as highway and air traffic control systems, robotic shopfloors, and other systems whose operation cannot be captured by conventional models. SHIFT is planned for use as a mechanism for defining the Automated Highway System Tool Interchange Format (AHSTIF). An automated highway system is a hybrid system with specific characteristics and restrictions. SHIFT supports the definition and enforcement of AHSTIF-specific semantics.
Human CD38 ligand. A 120-KDA protein predominantly expressed on endothelial cells. (1996)

Human CD38, a pleiotropic molecule with ADP-ribosyl cyclase activity, regulates activation and growth of several cell types. Its in vivo function is incompletely determined, mainly due to the lack of evidence concerning the existence of a single or multiple ligands. We recently observed that CD38 rules a selectin-type adhesion between lymphoid cells and HUVECs. A panel of murine mAbs raised against HUVEC included one (Moon-1) constantly blocking the CD38-mediated adhesion of several cell lines to HUVEC. Tissue distribution studies and an extended immunohistochemical analysis on the majority of normal human tissues revealed that the Moon-1 molecule displays a unique pattern of expression, being present at high levels on resting and activated vascular endothelium, on the majority of monocytes, platelets, NK cells, and to a lesser extent on T, B, and myeloid cells. The Moon-1 structure of an apparent molecular mass of 120 kDa proved to be a ligand for human CD38, as inferred by the direct binding observed when using a chimeric mouse CD8 alpha-human CD38 (mCD8 alpha-hCD38) molecule as a probe in Western blot experiments. Furthermore, Ab-induced modulation experiments highlighted an association between the Moon-1 molecule and human CD38 on the surface of cell lines coexpressing the two structures, which also share a common regulation system of surface expression. Finally, direct ligation of Moon-1 on T cell lines caused a relevant increase in the cytoplasmic concentration of calcium ([Ca2+]i).
Inversion de la forme d'onde dans le domaine fréquentiel de données sismiques grands offsets (2003)

L'approche standard en imagerie sismique repose sur une décomposition par échelle du modèle de vitesse: la détermination des bas nombres d'ondes est suivie par une reconstruction des hauts nombres d'ondes. Cependant, pour des modèles présentant une structure complexe, la détermination des hauts nombres d'ondes peut être améliorée de manière significative par l'apport des nombres d'ondes intermédiaires. Ces derniers peuvent être déterminés par l'inversion non-linéaire de la forme d'onde de données sismiques grands angles qui est, par ailleurs, limitée par la non-linéarité du problème inverse. La non-linéarité est gouvernée par la fréquence minimum dans les données et le modèle de vitesse initial. Pour les très basses fréquences, inférieures à 7 Hz, le problème est raisonnablement linéaire pour appliquer l'inversion de la forme d'onde à partir d'un modèle de départ déterminé par inversion tomographique des temps de trajets. Le domaine fréquentiel est alors très efficace pour inverser des basses vers les hautes fréquences. De plus, il est possible de discrétiser les fréquences avec un pas d'échantillonnage plus grand que celui dicté par le théorème d'échantillonnage. Une stratégie pour sélectionner les fréquences est développée qui réduit le nombre de fréquences nécessaire en imagerie lorsqu'une gamme d'offset est disponible: le nombre de fréquences diminue lorsque l'offset maximum augmente. Les donnés sismiques réelles ne contiennent malheureusement pas de très basses fréquences. Des techniques de pré-conditionnement doivent alors être appliquées afin d'améliorer l'efficacité de l'inversion à partir de fréquences réalistes. Le lissage du vecteur gradient ainsi que l'inversion des premières arrivées augmente les chances de convergence au minimum global. L'efficacité des méthodes de pré-conditionnement est tout de même limitée par le degré d'information contenu dans le modèle de départ.
Role of shape and kinematics in human movement analysis (2004)

Human gait and activity analysis from video is presently attracting a lot of attention in the computer vision community. In this paper we analyze the role of two of the most important cues in human motion-shape and kinematics. We present an experimental framework whereby it is possible to evaluate the relative importance of these two cues in computer vision based recognition algorithms. In the process, we propose a new gait recognition algorithm by computing the distance between two sequences of shapes that lie on a spherical manifold. In our experiments, shape is represented using Kendall's definition of shape. Kinematics is represented using a Linear Dynamical system We place particular emphasis on human gait. Our conclusions show that shape plays a role which is more significant than kinematics in current automated gait based human identification algorithms. As a natural extension we study the role of shape and kinematics in activity recognition. Our experiments indicate that we require models that contain both shape and kinematics in order to perform accurate activity classification. These conclusions also allow us to explain the relative performance of many existing methods in computer-based human activity modeling.
Supplementary Figure 3 from Secreted Frizzle-Related Protein 2 Stimulates Angiogenesis via a Calcineurin/NFAT Signaling Pathway (2023)

Supplementary Figure 3 from Secreted Frizzle-Related Protein 2 Stimulates Angiogenesis via a Calcineurin/NFAT Signaling Pathway
Factors Controlling Short‐Range Methane Migration of Gas Hydrate Accumulations in Thin Coarse‐Grained Layers (2019)

Abstract Natural gas hydrate is often found in marine sediment in heterogeneous distributions in different sediment types. Diffusion may be a dominant mechanism for methane migration and affect hydrate distribution. We use a 1‐D advection‐diffusion‐reaction model to understand hydrate distribution in and surrounding thin coarse‐grained layers to examine the sensitivity of four controlling factors in a diffusion‐dominant gas hydrate system. These factors are the particulate organic carbon content at seafloor, the microbial reaction rate constant, the sediment grading pattern, and the cementation factor of the coarse‐grained layer. We use available data at Walker Ridge 313 in the northern Gulf of Mexico where two ~3‐m‐thick hydrate‐bearing coarse‐grained layers were observed at different depths. The results show that the hydrate volume and the total amount of methane within thin, coarse‐grained layers are most sensitive to the particulate organic carbon of fine‐grained sediments when deposited at the seafloor. The thickness of fine‐grained hydrate free zones surrounding the coarse‐grained layers is most sensitive to the microbial reaction rate constant. Moreover, it may be possible to estimate microbial reaction rate constants at other locations by studying the thickness of the hydrate free zones using the Damköhler number. In addition, we note that sediment grading patterns have a strong influence on gas hydrate occurrence within coarse‐grained layers.
Scalable Neural Architectures for End-to-End Environmental Sound Classification (2022)

Sound Event Detection (SED) is a complex task simulating human ability to recognize what is happening in the surrounding from auditory signals only. This technology is a crucial asset in many applications such as smart cities. Here, urban sounds can be detected and processed by embedded devices in an Internet of Things (IoT) to identify meaningful events for municipalities or law enforcement. However, while current deep learning techniques for SED are effective, they are also resource- and power-hungry, thus not appropriate for pervasive battery-powered devices. In this paper, we propose novel neural architectures based on PhiNets for real-time acoustic event detection on microcontroller units. The proposed models are easily scalable to fit the hardware requirements and can operate both on spectrograms and waveforms. In particular, our architectures achieve state-of-the-art performance on UrbanSound8K in spectrogram classification (around 77%) with extreme compression factors (99.8%) with respect to current state-of-the-art architectures.
Near Infrared Light-Triggerd on-Demand Drug Delivery From Non-Toxic Hydrogel Microbeads with Heat Transducer (2021)

This paper describes a near-infrared (NIR) light-triggered drug release system using alginate hydrogel microbeads. As a drug carrier, calcium alginate hydrogel microbeads encapsulating heat transducing particle (Fe304 particles) were fabricated by a centrifugal based fabrication method. The Fe304 particles instantly generate heat due to localized surface plasmon resonance when irradiated with NIR light. As a result, the calcium alginate hydrogel is thermally denatured to release a drug model. By irradiating NIR-laser to the hydrogel microbeads, we confirmed the release of fluorescent polystyrene particles (~ 10 nm) as a drug model. This result indicates that the polymer network of the calcium alginate hydrogel responded to the heat at the molecular scale, even though calcium alginate hydrogel is generally stable to heat. This NIR light-triggered drug release system using Fe3O4 particles would be an effectiveand safe platform for on-demand drug delivery.
Introduction to the article by Harold Biswell: Prescribed Burning in Georgia and California Compared (2021)

Abstract Harold Biswell first learned about the benefits of prescribed fire in forest management when he was a Forest Service researcher in Georgia, USA. After he accepted a professorship in the School of Forestry at the University of California, Berkeley, USA, he was surprised to find out that prescribed fire was not an accepted practice in California. He set out to conduct a series of studies to explore the effects of prescribed fire in forests of California and compare those effects to those he observed in Georgia.
Adaptive intemally turbo-coded ultra wideband-impulse radio (AITC-UWB-IR) system (2004)

As a new spread spectrum system, an ultra wideband-impulse radio (UWB-IR) has attracted much attention in high speed indoor multiple access radio communications. Since the UWB-IR system repeats and transmits pulses for each bit, the UWB-IR system is considered as a coded scheme with a simple repetition block code. As an error correcting code, turbo-codes proposed by C. Berrou et al. in 1993 have attracted much attention beyond the field of coding theory, because the performance is very close to the Shannon limit with practical decoding complexity. In this paper, we propose an adaptive internally turbo-coded UWB-IR (AITC-UWB-IR) system. The proposed system employs a turbo code in addition to a repetition block code and shares the transmission bandwidth adaptively between them. We evaluate the performance of the AITC-UWB-IR by theoretical analysis and computer simulation. From our numerical and simulation results, we show that the BER of the AITC-UWB-IR is superior to that of the SOC-UWB-IR on an AWGN channel when the bit rate is high. We also showed that the AITC-UWB-IR system using low rate turbo codes improves the BER on an AWGN channel and a real Gaussian fading channel. Consequently, we confirm that for the same bit rate, we had better make the code rate of turbo codes lower and make the number of repetitions of the repetition codes smaller to achieve the better BER.
How To Use Adobe Photoshop CS2 (2005)

Have you ever looked at your color pictures and wished you could make them black and white? Or maybe you've dreamed about taking that photo of your brother, cutting the head off and placing it on the body of a grizzly bear. The tool that you need is Adobe Photoshop and the book you need to learn all about it is How to Use Adobe Photoshop CS 2. Visually step through the process of creating images, manipulating them and then optimizing them for print or the web. The step-by-step approach used throughout the book will make it simple to learn the basic techniques involved in using Photoshop. You will learn to: Convert files Work with tone and color Edit images using tools, paths and layers Build web filesMaster the basics of Photoshop with the visual examples and easy-to-follow lessons in How to Use Photoshop CS 2.
Assessment of three automated assays for C-reactive protein determination in dogs (2007)

The automated canine CRP assay had less interassay imprecision, compared with the ELISA. The 2 human CRP assays were not suitable for analysis of canine plasma samples. The automated canine CRP assay was more precise than the ELISA for serial evaluations of plasma CRP concentration in dogs.
A downstream-element-binding factor facilitates assembly of a functional preinitiation complex at the simian virus 40 major late promoter. (1990)

Recent work has shown that many promoters recognized by eucaryotic RNA polymerase II contain essential sequences located downstream of the transcriptional initiation site. We show here that the activity of a promoter element centered 28 base pairs downstream of the simian virus 40 major late initiation site appears to be mediated by a DNA-binding protein, which was isolated by affinity chromatography from HeLa cell nuclear extracts. In the absence of the other components of the transcriptional machinery, the protein bound specifically but weakly to its recognition sequence, with a Kd of approximately 10(-8) M. Analysis of kinetic data showed that mutation of the downstream element decreased the number of functional preinitiation complexes assembled at the promoter without significantly altering the time required for half the complexes to assemble. This suggests that in the absence of the downstream activating protein, preinitiation complexes are at least partially assembled but are not transcriptionally competent.
pH-Dependent Inhibitory Effects of Angiotensin-Converting Enzyme Inhibitors on Cefroxadine Uptake by Rabbit Small Intestinal Brush-Border Membrane Vesicles and Their Relationship with Hydrophobicity and the Ratio of Zwitterionic Species. (1999)

The inhibitory effects of five angiotensin-converting enzyme (ACE) inhibitors on the uptake of an aminocephalosporin antibiotic, cefroxadine, by rabbit small intestinal brush-border membrane vesicles were examined in the presence of an inward H+ gradient. Dixon plot analysis showed that all these ACE inhibitors inhibited the uptake of cefroxadine, which is transported by a H+/oligopeptide transporter in the membrane, in the order of enalapril<quinapril, benazepril<temocapril, trandolapril at extravesicular pH 6.0. These drugs, except for enalapril, which are relatively hydrophobic, exhibited a mix of competitive and noncompetitive inhibition. We also examined the inhibitory effects of quinapril and temocapril at extravesicular pH 5.5, at which the ratio of the zwitterionic species of the drugs increased. The inhibition occurred in a nearly competitive manner at this pH and the inhibitory effects were stronger than at pH 6.0. Regression analysis of the inhibitory effects suggested that the affinity of these ACE inhibitors for the transporter was regulated by the hydrophobicity of these ACE inhibitors and the ratio of the zwitterionic species of the drugs.
Down-modulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific T cell responses (IRM10P.737) (2014)

Abstract We report here that antigen-specific proliferative responses of naïve and memory CD4 T cells require the down-modulation of tumor suppressor p53. In the absence of TCR signal, IL-2 induces a sustained increase in p53 protein, which prevents proliferative responses despite strong signaling through the IL-2 receptor. In contrast, TCR signaling results in early termination of p53 protein expression by decreasing p53 mRNA as well as by strong transcriptional induction of the p53-regulating protein Mdm2. Down-modulation of p53 in response to antigen stimulation is in fact critical for antigen-specific T cell proliferation; and preventing p53 degradation by inhibiting Mdm2 results in sustained p53 protein levels and prevents antigen-specific T cell proliferation. These studies elucidate a critical role of p53 as a negative regulator of T cell proliferation. It is the termination of p53 elevation by TCR signaling that allows proliferative responses to occur, enforcing antigen specificity.
High-spin collective structures in178Pt (2000)

Collective structures in ${}^{178}\mathrm{Pt}$ have been investigated with $\ensuremath{\gamma}$-ray spectroscopic techniques following mass selection. The present data expand considerably the level scheme of this nucleus. A new collective structure has been identified and the known bands have been extended to higher spins. Firm spin and parity assignments have been made to many levels. Of particular interest are the negative parity bands which are interpreted in terms of structures associated with octupole vibrations crossed at moderate spin by two-quasiparticle excitations. The systematics of the $\ensuremath{\alpha}$-decay reduced widths in Pt nuclei has also been investigated. The differences of a factor of about 2 between the widths for the odd- and the even-$A$ isotopes is attributed to changes in neutron pairing associated with the blocking effect. The trend is reproduced in calculations based on the Lipkin-Nogami pairing model.
New Methods of Analyzing Tannins (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Methods of Analyzing TanninsTakuo Okuda, Takashi Yoshida, and Tsutomu HatanoCite this: J. Nat. Prod. 1989, 52, 1, 1–31Publication Date (Print):January 1, 1989Publication History Published online1 July 2004Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/np50061a001https://doi.org/10.1021/np50061a001research-articleACS PublicationsRequest reuse permissionsArticle Views1220Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands. (1993)

The mitochrondrial benzodiazepine receptor (mBzR) binds a subset of benzodiazepines and isoquinoline carboxamides with nanomolar affinity and consists of the voltage-dependent anion channel, the adenine nucleotide translocator, and an 18-kDa protein. The effect of ligands of the mBzR on two inner mitochondrial membrane channel activities was determined with patch-clamp techniques. The relative inhibitory potencies of the drugs resemble their binding affinities for the mBzR. Ro5-4864 and protoporphyrin IX inhibit activity of the multiple conductance channel (MCC) and the mitochondrial centum-picosiemen (mCtS) channel activities at nanomolar concentrations. PK11195 inhibits mCtS activity at similar levels. Higher concentrations of protoporphyrin IX induce MCC but possibly not mCtS activity. Clonazepam, which has low affinity for mBzR, is at least 500 times less potent at both channel activities. Ro15-1788, which also has a low mBzR affinity, inhibits MCC at very high concentrations (16 microM). The findings indicate an association of these two channel activities with the proteins forming the mBzR complex and are consistent with an interaction of inner and outer membrane channels.
Studies on biological methylation. Part XV. The formation of dimethyl selenide in mould cultures in presence of D- and L-methionine, or of thetins, all containing the 14CH3 group (1955)

P. B. Dransfield and F. Challenger, J. Chem. Soc., 1955, 1153 DOI: 10.1039/JR9550001153