gebhart/patrepeval huggingface dataset:
Supplementary Methods, Tables 1-3, Figures 1-6 from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells (2023)

Supplementary Methods, Tables 1-3, Figures 1-6 from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells
Analysis of Mountaintop Data Reductions. (1997)

Abstract : The Ozturk Algorithm is a statistical algorithm which determine the best probability density function (PDF) to approximate the input data. This report describes in detail the research performed, the insights gained and the results obtained during this effort. The work performed was to provide all the necessary items to automate the application of the Ozturk Algorithm to radar clutter data under the Rome Laboratory Space-Time Adaptive Processing/Algorithm Development Tool (RLSTAP/ADT). These items are divided into five sections for this report; Requirements for Measured Clutter Data, Khoros Flow Control Mechanism, Modification of the Ozturk Algorithm Modules, Implementation of the Graphics for a Range-Angle Map, and Implementation of the Ozturk Algorithm Loop Application. The automated range-angle Ozturk Algorithm loop application was completed under RLSTAP/ADT and all necessary modules and change sets were provided for integration into Rome Lab's resident version.
Relationship between Mesogenic Side Chain Fraction in Liquid Crystalline Copolymer and Bistable Electro-Optical Switching for (Liquid Crystalline Copolymer/Liquid Crystals) Composite Systems (1998)

The influence of the mesogenic side chain fraction in a side chain liquid crystalline copolymer (LCcoP) on electro-optical effects for (LCcoP/low-molecular-weight nematic liquid crystals (nematic LCs)) composite systems in a smectic state was studied in order to improve reversible and bistable electro-optical switching characteristics driven by ac electric fields with two different frequencies. In the case of the LCcoP fraction lower than 40 wt %, the magnitudes of glass transition temperature (Tg) and the mesophase temperature range for the binary composite systems were independent of the mesogenic side chain fraction in LCcoP, that is, ∼220 K and 220−340 K, respectively. In the case of the LCcoP fraction of 30 wt % and, also, its mesogenic side chain fraction of 52.5 and 32.5 mol %, the binary composite systems showed a homogeneous smectic phase at room temperature. On the other hand, the LCcoP with the mesogenic side chain fraction 16.5 mol % did not exhibit any mesomorphic characteristics at any temperature without any addition of LCs. Then, this LCcoP was named as the pseudo-LCcoP in this study. However, the (pseudo-LCcoP/nematic LCs) composite system showed a novel type of induced smectic phase over a wide range of both mixing concentration (35−85 wt % pseudo-LCcoP) and temperature (220−320 K). This composite system showed a fast switching speed from a transparency state to a light-scattering state. Therefore, it was reasonably concluded that the application of LCcoP with the optimum substituent fraction of mesogenic side chain is useful to realize a high electro-optical switching speed (∼50 ms) as well as a stable memory effect (∼years) at room temperature.
An Electron Beam Method for Creating Combinatorial Libraries: Application to Next Generation Thermal Barrier Coatings Systems (2002)

The next generation of thermal barriers coating (TBC) systems used on turbine engines must be able to endure higher operating temperatures. The thermally protective top coat layers of these TBC systems must therefore exhibit lower thermal conductivity and improved thermochemical stability. The underlying bond coat layers should have substantially improved oxidation resistance and increased high temperature strength. These properties strongly depend upon coating composition. However, as these layers become increasingly complex the relationship between composition and properties becomes difficult to predict and thus, the development of advanced materials systems is slowed. To accelerate the design and manufacture of advanced coatings we have developed a combinatorial synthesis approach. A library of compositions is created and their properties are measured using parallel measurement techniques to allow rapid investigation of a wide range of compositions. Compositionally graded libraries are directly deposited using multi-source electron beam evaporation in conjunction with an inert, transonic gas jet. The properties of the gas jet control the degree of intermixing between co-evaporated melt pools and thus, the compositional gradient of the library. Direct Simulation Monte Carlo simulations along with binary collision theory has been used to investigate the origin of the lateral compositional variation. Deposition conditions which lead to sharp, lateral composition gradients across a substrate have been identified.
Bone Mineral Density in Estrogen-Deficient Young Women (2009)

Women with POI have lower bone density compared to regularly menstruating women. Compared to Caucasians, minority women with estrogen deficiency are more likely to have BMD below the expected range for age. This racial disparity appears to be related to a combined effect of several modifiable risk factors. Delay in diagnosis of POI also contributes to reduced bone density by delaying proper therapy.
Cardiorespiratory Fitness, Different Adiposity Exposures, and Cardiovascular Disease Mortality Risk in Healthy Women (2018)

PURPOSE: We examined the prospective associations among cardiorespiratory fitness (CRF), different adiposity exposures, and cardiovascular disease (CVD) mortality in women. METHODS: 19,838 apparently healthy women without history of CVD completed a comprehensive baseline health examination between 1970 and 2013. Clinical measures included body mass index (BMI), waist circumference (WC), waist-to-height ratio (W:HT), percent body fat (%Fat), and CRF quantified as duration of a maximal treadmill exercise test. Women were classified by CRF as low (quintile 1), moderate (quintiles 2-3), and high fit (quintiles 4-5) as well as by standard clinical cut points for adiposity exposures. Hazard ratios (HRs) were computed using Cox regression analysis. RESULTS: During a mean follow-up period of 19.2 ± 10.3 years, 391 CVD deaths occurred. Adjusted mortality rates for high, moderate, and low CRF groups were 0.55, 1.28, and 2.0 deaths/10,000 woman-years, respectively (p for trend <.001). Adjusted mortality rates of overweight women within each adiposity exposure were higher when compared with normal-weight women (p<.001). When grouped for joint analyses into CRF x adiposity categories, there was a significant positive trend in CVD mortality across decreasing categories of CRF within each category of W:HT and %Fat, as well as within the normal and overweight BMI categories and the normal WC category (p<.03). CRF was not significantly associated with CVD mortality within the obese BMI or high WC categories. CONCLUSION: Higher levels of CRF are associated with lower CVD mortality risk in women, and attenuate the risk of CVD mortality in overweight women. The use of various adiposity measures to estimate CVD mortality risk in women may be misleading unless CRF is also considered. These findings support the 2016 American Heart Association Scientific Statement recommending that CRF measurement or estimation be included in routine clinical practice.
In praise of joint sessions (2009)

The working premise for this article is that over the last three to five years we have seen a move away from mediators doing their work in joint session with all the mediation parties together at the table towards the process becoming dominated by private or caucus sessions where the mediator meets separately with individual parties only. This article, which is written in the context of mediating the litigated case, will deal with this increasing trend among mediators to do away with a joint session and adopt a shuttle mediation model. This is an especially topical debate among mediators with some advocating that a purely caucus model saves time and is what the market now requires. This contrasts with other mediators resisting the demise of the joint session, saying it is at the heart of what we do.
Advantages of NIR radiation use for optical determination of skin horny layer thickness with embedded TiO2 nanoparticles during tape stripping procedure (2006)

The tape stripping technique is an experimental method frequently used for reconstruction of the in-depth distribution of various topically administered substances within the horny layer of human skin, e.g., compounds contained in sunscreens. Titanium dioxide (TiO2) nanoparticles (25–200 nm in diameter) are one such compound. Optical techniques which apply blue light are found to be suitable for reconstruction. However, the presence of particles affects the light propagation within the skin and therefore causes incorrect determination of strip thickness, leading to an improper reconstructed distribution of nanoparticle concentration revealed from the experimental data. This study evaluates the errors emerging from the use of blue (400 nm) and NIR (800 nm) radiation and finds the use of longer wavelength light more advantageous. Particles of different diameters are considered, and it is revealed that the application of small particles (25–60 nm) results in the lowest rate of error.
Pyruvoyl Chloride (2001)

[5704-66-5] C3H3ClO2 (MW 106.51) InChI = 1S/C3H3ClO2/c1-2(5)3(4)6/h1H3 InChIKey = AUUTXOKCFQTKPL-UHFFFAOYSA-N (α-ketoacylating agent; selective oxidation of alcohols) Physical Data: light yellow liquid; bp 53 °C/126 mmHg. Solubility: sol CCl4, Et2O, THF, etc. Preparative Methods: most of the conventional reagents for the synthesis of acid chlorides from carboxylic acids are unsatisfactory for the preparation of pyruvoyl chloride. For example, treatment of pyruvic acid with Phosgene or Oxalyl Chloride11 affords the acid chloride in low yield. The method of choice for the preparation of the title compound1 is the reaction of pyruvic acid with Dichloromethyl Methyl Ether12, 13 to yield chloromethoxymethyl pyruvate, which readily decomposes into pyruvoyl chloride and methyl formate at 50 °C (eq 1).13 This simple and economical procedure has also been used for the preparation of other α-keto acid chlorides.1 (1) Another facile, but less often used, method for the preparation of pyruvoyl chloride involves the treatment of trimethylsilyl pyruvate, derived from pyruvic acid and Chlorotrimethylsilane, with oxalyl chloride in DMF solution (eq 2).2 (2) Handling, Storage, and Precautions: pyruvoyl chloride reacts vigorously with moisture, giving off fumes of HCl. It should be stored at −20 °C as the pure liquid in a sealed tube or in CCl4 solution. The compound may be characterized as the p-nitroanilide derivative.1a Use in a fume hood.
Explorations of sequential ATPG using Boolean satisfiability (2002)

Presents a sequential test generation method based on Boolean satisfiability. The method produces near-minimal test sizes. The authors discuss the flexibility provided by Boolean satisfiability to extend the fault model to realistic faults. Experimental results using ISCAS-89 benchmark circuits and comparisons with previously published results are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: A FORMAL TOTAL SYNTHESIS OF VALIDAMYCIN A (1983)

Abstract Aus Validoxylamin A (Ia) wird über die im Formelschema angegebenen Zwischenstufen (Ib) ‐ (le) und (IIIa)‐(IIIc) das Validamycin A (IIId) synthetisiert.
Ground and Excited State Dipole Moments of BADAN and ACRYLODAN Determined from Solvatochromic Shifts of Absorption and Fluorescence Spectra (2001)

Abstract The electric dipole moments in the ground μ g , and excited states μ e of the fluorescent probes BADAN (6-bromoacetyl-2-dimethylamino-naphthalene) and ACRYLODAN (6-acrylolyl-2-dimethylamino-naphthalene) are determined from the solvatochromic shifts of their absorption and fluorescence spec­tra for two Onsager interaction radii (a = 4.2 and 4.6 Å). The obtained values of μ g and μ e for BADAN are comparable to those of PRODAN, while for ACRYLODAN they are distinctly greater.
Hypertrophied Facial Fat in An HIV-1-Infected Patient after Autologous Transplantation from ‘Buffalo Hump’ Retains a Partial Brown-Fat-Like Molecular Signature (2013)

Despite being implanted in a former lipoatrophic area, facially grafted 'buffalo hump' tissue appears to retain the altered phenotype of dorso-cervical adipose cells, thus accounting for its progressive enlargement. These results argue that caution should be exercised when considering 'buffalo hump' fat depots as a fat source for autologous transplantation.
Inheritance of Low-Phytate Phosphorus in Soybean (2004)

A reduction in the phytic acid (phytate) content of soybean [Glycine max (L.) Merr.] seed would improve the bioavailability of P in rations of nonruminant animals containing soybean meal. A soybean mutant with low phytate and increased inorganic P was developed by the USDA-ARS and Purdue University. The objective of this study was to determine the inheritance of low phytate in a line derived from the mutant. The low-phytate line was crossed reciprocally to a line with normal phytate. The F1 seeds from the reciprocal crosses had normal phytate, indicating complete dominance for the wild-type alleles and no maternal effects. The segregation of 210 F2 seeds satisfactorily fit a phenotypic ratio of 15:1 normal to low phytate. The F2–derived lines satisfactorily fit a ratio of 7:8:1 homogeneous normal phytate to segregating to homogeneous low phytate. The segregation ratios indicated that low phytate was controlled by recessive alleles designated pha1 and pha2 at two independent loci that exhibited duplicate dominant epistasis. Both of the alleles must be homozygous to obtain low-phytate seed.
Paul Jorion, Principes des systèmes intelligents (2012)

L’ouvrage de Paul Jorion constitue une introduction rigoureuse et prealable a une reflexion et a un travail dans le champ de l’intelligence artificielle ‑ c’est a ce titre que nous le recommanderions comme lecture introductive a des etudiants en robotique. Il a le merite de poser les problemes d’ordre logique, psychologique et dans une moindre mesure anthropologique qui travaillent ce champ disciplinaire (mobilisant a ce titre une vaste erudition). La lecture des Principes des systemes intell...
Regulation of APD and Force by the Na+/Ca2+ Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue (2022)

The physiological importance of NCX in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is not well characterized but may depend on the relative strength of the current, compared to adult cardiomyocytes, and on the exact spatial arrangement of proteins involved in Ca2+ extrusion. Here, we determined NCX currents and its contribution to action potential and force in hiPSC-CMs cultured in engineered heart tissue (EHT). The results were compared with data from rat and human left ventricular tissue. The NCX currents in hiPSC-CMs were larger than in ventricular cardiomyocytes isolated from human left ventricles (1.3 ± 0.2 pA/pF and 3.2 ± 0.2 pA/pF for human ventricle and EHT, respectively, p < 0.05). SEA0400 (10 µM) markedly shortened the APD90 in EHT (by 26.6 ± 5%, p < 0.05) and, to a lesser extent, in rat ventricular tissue (by 10.7 ± 1.6%, p < 0.05). Shortening in human left ventricular preparations was small and not different from time-matched controls (TMCs; p > 0.05). Force was increased by the NCX block in rat ventricle (by 31 ± 5.4%, p < 0.05) and EHT (by 20.8 ± 3.9%, p < 0.05), but not in human left ventricular preparations. In conclusion, hiPSC-CMs possess NCX currents not smaller than human left ventricular tissue. Robust NCX block-induced APD shortening and inotropy makes EHT an attractive pharmacological model.
Hydrodynamic Simulation of Horizontal Slurry Pipeline Flow Using ANSYS-CFX (2009)

The behavior of horizontal solid−liquid (slurry) pipeline flows was predicted using a transient three-dimensional (3D) hydrodynamic model based on the kinetic theory of granular flows. Computational fluid dynamics (CFD) simulation results, obtained using a commercial CFD software package, ANSYS-CFX, were compared with a number of experimental data sets available in the literature. The simulations were carried out to investigate the effect of in situ solids volume concentration (8 to 45%), particle size (90 to 500 μm), mixture velocity (1.5 to 5.5 m/s), and pipe diameter (50 to 500 mm) on local, time-averaged solids concentration profiles, particle and liquid velocity profiles, and frictional pressure loss. Excellent agreement between the model predictions and the experimental data was obtained. The experimental and simulated results indicate that the particles are asymmetrically distributed in the vertical plane with the degree of asymmetry increasing with increasing particle size. Once the particles are sufficiently large, concentration profiles are dependent only on the in situ solids volume fraction. The present CFD model requires no experimentally determined slurry pipeline flow data for parameter tuning, and thus can be considered to be superior to commonly used, correlation-based empirical models.
A quantitative method for mono- and multistatic radar coverage area prediction (2010)

The prediction of radar coverage as a function of the position of the radar has always been a key step in radar network planning. In the past, simple geometric models backed up by the deployment of siting radars were the only options for potential site evaluation, but the development of sophisticated propagation models (e.g. AREPS [1]) has moved the technology forward to another level of prediction accuracy. Modelling takes into account atmospheric refraction, as well as terrain effects and clutter. In previous papers [2], [3] we have shown that the modelling can also cater for multistatic radar systems. In this paper we have extended our modelling to give a statistical measure of the effectiveness of a site that measures the signal to noise ratio (SNR) or (for multistatic radar) the signal to interference ratio (SIR) over regions of interest. The area is pixellated into values of SNR and SIR, and pixels meeting the required SNR and / SIR are counted. We show some results for a multistatic radar. We conclude by indicating how we plan to include ground clutter. We mention how this method of obtaining quantitative coverage performance can be used with all forms of radar, and will be able to improve future networks of cognitive radars.
An Encapsulated Energy Harvesting Platform for On-road Low Power Sensing Systems (2019)

The development of the emerging Smart Cities concept aims to enhance city infrastructures and services via the capabilities offered by information and communication technologies (ICT). One of the Smart City main pillars is Smart Mobility. Improvements to the existing physical transportation infrastructure are necessary, to accommodate safety and efficiency. This paper provides a technical overview regarding energy harvesting and packaging issues of the European Horizon 2020 funded project on Safe and green Sensor Technologies for self-explaining and forgiving Road Interactive aPplications (SAFE STRIP). In particular, it focuses on the integration of a number of on-road entities, named as On Road Units (ORU), into an intelligent road tapes/markers in order to improve road surface condition monitoring, traffic and safety. Even though ORU consists of multiple modules (ambient condition sensors, traffic sensors, communication, etc.), here we choose to discuss critical aspects regarding energy provisioning and harvesting, and packaging of this particular system. Particularly, besides primary and secondary batteries, we incorporate solar and piezoelectric harvesters as well as wireless charging receivers and antennas, while all of them co-exist under a hierarchical schema. Finally, we provide a design and implementation study, while results from a number of simulations are also outlined.
Isolation and Quantification of Exosomes (2015)

Cells are communicating each other by exchanging their nucleic acids, proteins, metabolites, lipids etc, many of them are carried by extracellular vesicles (EVs) including exosomes and microvesicles. Thus, exosomes are rich sources of information regarding the host cells that released them. In this review, I introduce a brief history of exosome researches and discuss about what are needed at the moment to establish the “exosome medicine”.
ChemInform Abstract: A New Two‐Step Stereospecific Synthesis of Glycidic Spiroacetals. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Caractérisation du comportement cyclique d'un matériau tissé en traction ondulée (2008)

Des résultats expérimentaux sur un matériau tissé en fils de polyamide 6-6 (PA66) sont présentés. Les essais ont été effectués d'une part en traction monotone à différentes vitesses de déformation et d'autre part en sollicitations cycliques sophistiqués de type traction ondulée avec des séquences de fluage ou de relaxation.
Chemistry of tricarbonyl hemiketals and application of Evans technology to the total synthesis of the immunosuppressant (-)-FK-506 (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of tricarbonyl hemiketals and application of Evans technology to the total synthesis of the immunosuppressant (-)-FK-506Todd K. Jones, Robert A. Reamer, Richard Desmond, and Sander G. MillsCite this: J. Am. Chem. Soc. 1990, 112, 8, 2998–3017Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ja00164a023https://doi.org/10.1021/ja00164a023research-articleACS PublicationsRequest reuse permissionsArticle Views2950Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts