gebhart/patrepeval huggingface dataset:
Esm1 and Stc1 as Angiogenic Factors Responsible for Protective Actions of Adipose-Derived Stem Cell Sheets on Chronic Heart Failure After Rat Myocardial Infarction (2021)

ADSC sheets improved cardiac contractile functions after MI by suppressing cardiac fibrosis and enhancing neovascularization. Transplanted ADSCs existed for >2 weeks on MI hearts and produced the angiogenic factors Esm1 and Stc1, which may improve cardiac functions after MI.
Struktur und Wirkung von Insulin, IX. Merrifield-Synthesen variierter A-Ketten unter Verwendung verschiedenerS-Alkylmercapto-Schutzgruppen (1971)

Article Struktur und Wirkung von Insulin, IX. Merrifield-Synthesen variierter A-Ketten unter Verwendung verschiedener S-Alkylmercapto-Schutzgruppen was published on January 1, 1971 in the journal Biological Chemistry (volume 352, issue 1).
The great contribution: Index Medicus, Index-Catalogue, and IndexCat (2009)

Inclusion, form, content, authority control, and subject headings were evaluated, revealing that the relationship between the two publications was neither simple nor static through time. In addition, the authors found interesting anomalies that shed light on how medical literature was selected and indexed in "America's greatest contribution to medical knowledge."
Oxcarbazepine form III : observation of twisted habit in crystals of an elusive pharmaceutical polymorph (2019)

Crystals exhibiting twisted habit have been observed at the nanoscale, mesoscale, and macroscale and pose challenges with respect to structural characterisation because of their lack of long-range translational symmetry [1]. Crystal structure prediction (CSP) investigations of an active pharmaceutical ingredient’s lattice energy landscape are a potent tool for assisting experimentalists in identifying and characterising novel polymorphic forms that are thermodynamically feasible, including ones that crystallise with twisted morphologies [2-4]. Oxcarbazepine (OXCBZ) is a pharmaceutical used for the treatment of epileptic seizures and three polymorphic forms have been reported, two of which (form I and form II) crystallise in the monoclinic space groups P21/c and P21 respectively [5]. OXCBZ form III was originally prepared by slow evaporation from methanol solutions containing polymer additives but structure determination was not possible because of the small size and poor quality of the crystals produced. Herein, we present robust protocols for the crystallisation of OXCBZ III from both solution and the vapour phase. Our efforts combined CSP studies of OXCBZ with physical vapour deposition and solution-based polymorph screening experiments. Needle-like and fibre-like crystals of form III exhibiting variable twisted habit were serendipitously obtained through vapour deposition of OXCBZ onto metallic substrates. By performing scanning electron and atomic force microscopy investigations we have managed to gain insight into the mechanism of formation and growth of the twisted OXCBZ III crystals over the course of the deposition process.
[Hand transplantation and implantation of nerve chips. New developments within hand surgery]. (2000)

Injuries and diseases of the hand naturally have an enormous impact on hand function and on quality of life, both occupational and social. The majority of hand-injury patients are under 30 years of age. Hand surgery, an established specialty in Sweden since 1969, is of great importance in terms of clinical developments, education and research. In the coming decade, scientific and clinical advances are to be expected in several fields such as nerve injuries including brachial plexus lesion, microsurgery, flexor tendon injuries and tendon transfer. Bioimplant research and new advances at the biotechnological interface will yield new options in nerve reconstruction, microchip implants in the nervous system, and the restoration of muscle-tendon function following injury. Artificial limbs with advanced motor and sensory functions will be important future aids in the rehabilitation of amputees. Transplantation of human hands is another promising reconstructive procedure which may open iup new perspectives in the coming millennium.
miR-21 Expression in Cancer Cells may Not Predict Resistance to Adjuvant Trastuzumab in Primary Breast Cancer (2014)

Trastuzumab is established as standard care for patients with HER2-positive breast cancer both in the adjuvant and metastatic setting. However, 50% of the patients do not respond to the trastuzumab therapy, and therefore new predictive biomarkers are highly warranted. MicroRNAs (miRs) constitute a new group of biomarkers and their cellular expression can be determined in tumor samples by in situ hybridization (ISH) analysis. miR-21 is highly prevalent and up-regulated in breast cancer and has been linked to drug resistance in clinical and in vitro settings. To determine expression patterns of miR-21 in high-grade breast cancers, we examined miR-21 expression in 22 HER2-positive tumors and 15 HER2-negative high-grade tumors by ISH. The histological examination indicated that patient samples could be divided into three major expression patterns: miR-21 predominantly in tumor stroma, predominantly in cancer cells, or in both stromal and cancer cells. There was no obvious difference between the HER2-positive and HER2-negative tumors in terms of the miR-21 expression patterns and intensities. To explore the possibility that miR-21 expression levels and/or cellular localization could predict resistance to adjuvant trastuzumab in HER2-positive breast cancer patients, we analyzed additional 16 HER2-positive tumors from patients who were treated with trastuzumab in the adjuvant setting. Eight of the 16 patients showed clinical recurrence and were considered resistant. Examination of the miR-21 expression patterns and intensities revealed no association between the miR-21 scores in the cancer cell population (p = 0.69) or the stromal cells population (p = 0.13) and recurrent disease after adjuvant trastuzumab. Thus, our findings show that elevated miR-21 expression does not predict resistance to adjuvant trastuzumab.
Production of ß‐galactosidase in liquid cultures ofbeauveria bassiana. (1991)

Abstract Beauveria bassiana, a filamentous fungus produced ß‐galactosidase when grown on arabinose, fructose, galactose, gelatin, glucose, glutamate, lactose, mannitol, mannose, maltose, sucrose or xylose. The synthesis of ß‐galactosidase started with the onset of mycelial growth (developmental stage III) and continued throughout later stages of growth. The majority of the ß‐galactosidase activity was cell associated. However, 15% of the total ß‐galactosidase activity was found in the culture supernatant. ß‐Galactosidase synthesis in B. bassiana was observed from all media types and the level of activity was influenced by carbon source. Synthesis was greatest when the organism was grown on 0.1% sucrose. A combination of glucose and nitrogen compounds reduced the levels of ß‐galactosidase activity three fold when compared to the enzyme expression during fungal growth on glucose alone.
Information criteria performance for feature selection (2011)

This paper shows the information criteria (IC) performances in feature selection framework. Feature selection aims to select a representative subset among a wide set of features. We apply this approach to classify an hand segmented image. The performance is tested using various feature selection schemes (SFS, SBS, SFFS and SBFS) to select the candidate subsets. The accuracy of the approach is based on a good quality of the joint probability density approximation of the combined features. They are obtained using histogram optimized thanks to the adaptive arithmetic coding principles. Our approach is tested on different reference data. The subsets quality is evaluated using correct classification rate computed on multiple classifiers. Results show stability and convergence properties of this tool and its ability to select representative subsets (in the sense that the subset of feature is a good characterization of the classes in which the data belong). Information Criteria could be used for feature selection as a good alternative to other criteria.
Neuroretinal atrophy following resolution of macular oedema in retinal vein occlusion (2018)

In this exploratory analysis, we describe the characteristics of neuroretinal atrophy in RVO eyes with resolved macular oedema after ranibizumab therapy. Our analysis shows significant, predominantly retinal thinning in the IPL to ONL compartment in focal macular areas in 11% of patients with RVO. Eyes with retinal atrophy did not show poorer BCVA outcomes.
Effect of Ti Addition on Oxidation Behavior of High-Purity Ferritic Stainless Steel (2018)

The effect of Ti addition on the oxidation resistance of high-purity 19%Cr ferritic stainless steels has been investigated during isothermal heat treatment at temperatures between 1073 K and 1273 K in air. The microstructures of scale and the scale/metal interface were investigated in detail by means of SEM-EBSD and FE-TEM together with μ-EDS.
Automation Provides Unique Insights of The Rock Record and Subsurface Through the Delivery of a Robotic Sample Collection and Analysis Device (2018)

Abstract Objectives/Scope From the very early days of oil and gas exploration, appraisal and development drilling, samples have been collected at the rig by mud logging personnel to conduct a preliminary geological analysis of the rock being drilled. This collection typically involves a sample collection recipient, board or bucket to collect a sample of rock over the desired interval. The sample is then sieved and cleaned in the appropriate way depending on the type of drilling fluid being used. As penetration rates have increased in some instances to more than 400 ft. / hr. the sample resolution has deteriorated exponentially. From an ergonomics perspective, the highest frequency to which a person onsite can collect a sample is once every 20 minutes. At 300 ft. / hr. this translates to 100 ft. of drilled rock. A new device has been developed and deployed which automates this manual process and thus ensures faster and more accurate collection of geological samples of the drilled rock interval. Sample resolutions of 5ft rock intervals have been attained at 400 ft./ hr. This technology has provided an important technological breakthrough and enables reduction of personnel at the rig site with a subsequent reduction in cost and HSE risk, particularly in areas of H2S. It further has provided for the potential integration with Measurement while drilling personnel. For both conventional and unconventional play development, this has provided oil and gas operators with an important and cost and risk reducing modus operandi compared to conventional drilling and evaluation techniques. The tool was deployed for an operator in West Texas where both manually collected traditional mudlog samples and automatically collected samples were taken. The samples were analyzed and compared for rock content. In addition, comparisons were made between point sampling with the automated system versus samples collected over a defined interval manually. Results of these comparisons will be presented. Results, Observations, Conclusions A new method of automated drill cuttings sample collection has been successfully deployed. The new method provides a step change improvement in accuracy and resolution for sampling the rock record during drilling. Novel/Additive Information Additional data of the rock record provides potential insights to optimize wellbore placement and provide increased geo-mechanical data to optimize completions.
Correction to Orientation Control of Interfacial Magnetism at La0.67Sr0.33MnO3/SrTiO3 Interfaces (2017)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Orientation Control of Interfacial Magnetism at La0.67Sr0.33MnO3/SrTiO3 InterfacesEr-Jia Guo*, Timothy Charlton, Haile Ambaye, Ryan D. Desautels, Ho Nyung Lee, and Michael R. Fitzsimmons*Cite this: ACS Appl. Mater. Interfaces 2017, 9, 31, 26630Publication Date (Web):July 26, 2017Publication History Published online26 July 2017Published inissue 9 August 2017https://pubs.acs.org/doi/10.1021/acsami.7b10078https://doi.org/10.1021/acsami.7b10078correctionACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views655Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (122 KB) Get e-Alertsclose Get e-Alerts
Dibenzotetraaza[14]Annulene Complexes. Part. 3: Mesomorphic Properties of Six and Eight Chain Substituted Compounds (1997)

Abstract The mesomorphic properties of some dibenzotetraaza[14]annulene complexes bearing six and eight alkoxy chains have been investigated by microscopic observations, DSC experiments and X-ray diffraction. In each case, D h phases were identified. The influence of the number, the length and the position of the grafted chains on the liquid crystal behaviour is discussed.
Respect the ORIGIN! (2022)

Connection coalescing, enabled by HTTP/2, permits a client to use an existing connection to request additional resources at the connected hostname. The potential for requests to be coalesced is hindered by the practice of domain sharding introduced by HTTP/1.1, because subresources are scattered across subdomains in an effort to improve performance with additional connections. When this happens, HTTP/2 clients invoke additional DNS queries and new connections to retrieve content that is available at the same server. ORIGIN Frame is an HTTP/2 extension that can be used by servers to inform clients about other domains that are reachable on the same connection. Despite being proposed by content delivery network (CDN) operators and standardized by the IETF in 2018, the extension has no known server implementation and is supported by only one browser. In this paper, we collect and characterize a large dataset. We use that dataset to model connection coalescing and identify a least-effort set of certificate changes that maximize opportunities for clients to coalesce. We then implemented and deployed ORIGIN Frame support at a large CDN. To evaluate and validate our modeling at scale, 5000 certificates were reissued. Passive measurements were conducted on production traffic over two weeks, during which we also actively measured on the 5000 domains.
2° Analyse factorielle (1952)

Bernyer G., Fraisse P. 2° Analyse factorielle. In: L'année psychologique. 1952 vol. 52, n°2. pp. 647-651.
Pediatric genitourinary tumors (1991)

Childhood genitourinary tumors are rare and continue to demand collaborative protocols to accumulate adequate numbers of patients for studies, and a multidisciplinary approach for treatment. This paper reviews all the 1990 literature on the most common of these tumors--Wilms' and testicular tumors and rhabdomyosarcoma. The molecular and cellular biology and pathology of Wilms' tumor, as well as treatment advances, are discussed, emphasizing attempts to minimize treatment morbidity and mortality while maintaining optimal quality and quantity of life.
Circulating Cardiac Autoantibodies in Dilated Cardiomyopathy and Myocarditis: Pathogenetic and Clinical Significance (2002)

Dilated cardiomyopathy (DCM) is a relevant cause of heart failure and a common indication for heart transplantation. It may be idiopathic, familial/genetic, viral, autoimmune or immune-mediated associated with a viral infection. Myocarditis is an inflammatory disease of the myocardium; it may be idiopathic, infectious or autoimmune and may heal or lead to DCM. Thus, in a patient subset, myocarditis and DCM are thought to represent the acute and chronic stages of an organ-specific autoimmune disease of the myocardium. In keeping with this hypothesis, autoimmune features in patients with myocarditis/DCM include: familial aggregation; a weak association with HLA-DR4; abnormal expression of HLA class II on cardiac endothelium on endomyocardial biopsy; and detection of organ- and disease-specific cardiac autoantibodies of the IgG class in the sera of affected patients and symptom-free relatives. The cardiac autoantibodies detected by immunofluorescence are directed against multiple antigens. Two of these, first identified using immunoblotting and confirmed by ELISA, are the atrial-specific alpha- and the ventricular and skeletal muscle beta-heavy chain isoform. The alpha-myosin isoform fulfils the expected criteria for organ-specific autoimmunity, in that immunization with cardiac, but not skeletal myosin reproduces, in susceptible mouse strains, the human disease phenotype of myocarditis/DCM; in addition, alpha-myosin is entirely cardiac-specific. Additional antigenic targets of heart-reactive autoantibodies include unknown sarcolemmal proteins, mitochondrial enzymes, beta-adrenergic and muscarinic receptors. For some of these antibodies, there is in vitro evidence for a functional role. The organ-specific cardiac autoantibodies detected by immunofluorescence in symptom-free relatives were associated with echocardiographic features suggestive of early disease. Mid-term follow-up suggests that these antibodies are predictive markers of progression to DCM among symptom-free relatives with or without abnormal echocardiographic findings.
Germline polymorphisms of the VEGF-pathway predict recurrence in non-advanced differentiated thyroid cancer (2016)

Analysis of germline VEGF-A SNPs could empower a prognostic approach to DTC.
Transplantation osteoporosis (2001)

Transplantation osteoporosis causes significant morbidity in the growing population of survivors of organ transplantation. Rapid bone loss and increased fracture rates, particularly in the first 6 to 18 months after transplantation, have been associated with the independent and combined effects of immunosuppressive medications such as glucocorticoids, cyclosporine, and tacrolimus. In contrast to the low-turnover bone disease found in glucocorticoid-induced osteoporosis, a high-turnover state is found in the posttransplant period. No pretransplantation variables reliably predict posttransplantation bone loss or fracture risk in the individual patient. As a result, preventative therapy should be considered in all organ transplant recipients. Such therapy should be instituted immediately after transplantation, because most bone loss occurs during this early period. Preventive regimens including calcium, vitamin D metabolites, hormone replacement therapy, calcitonin, and bisphosphonates have been studied. Currently, antiresorptive therapy with bisphosphonates is the most promising approach to the prevention and treatment of transplantation osteoporosis.
In vivo responses to inhaled proteins. II. Induction of interstitial pneumonitis and enhancement of immune complex-mediated alveolitis by inhaled concanavalin A. (1979)

An animal model of environmental lung disease is described in which phytomitogen, antigen, or both, are administered in aerosol form to previously immunized or immunologically naive rabbits. Inhalation of concanavalin A alone induced an interstitial pneumonitis in nonimmunized rabbits. Inhalation of concanavalin A alone induced an interstitial pneumonitis in nonimmunized rabbits. Inhalation of bovine serum albumin (BSA) alone typically produced only focal eosinophilic granulomas in BSA-immunized animals, and no injury whatever in nonimmune animals. However, simultaneous administration of BSA-concanavalin A aerosol mixtures to BSA-immunized rabbits induced a severe interstitial pneumonitis and granulomatous vasculitis, together with areas of frank parenchymal necrosis. When repeated on a chronic basis over a 4- or 8-week interval, challenge with BSA-concanavalin A aerosols resulted in both acute necrotic lesions as well as areas of frank interstitial fibrosis. Necrotic foci in acutely injured lungs were associated with interstitial deposits of BSA, rabbit anti-BSA antibody, and complement. Electron microscopy revealed numerous neutrophils within the pulmonary interstitial spaces of these animals, often in association with collagen and elastin fibers. The pattern of injury in immune rabbits induced by antigen-concanavalin A aerosols, in its nonnecrotizing form, is consistent with that of an extrinsic allergic alveolitis. However, the severe, necrotizing form of acute injury closely resembles changes seen in Wegener's granulomatosis. Possible mechanisms of injury produced by antigen and phytomitogen inhalation are discussed.
Lack of implementation of Hepatitis B Virus (HBV) vaccination policy in household contacts of HBV carriers in Italy (2009)

Understanding the different uptake of hepatitis B vaccination in these populations may provide useful information for optimizing vaccination campaigns in other contexts. Our data clearly demonstrated the need of improving the uptake of vaccination for household contacts of HBV carriers.
Enhancing the Data Collection Rate of Tree-Based Aggregation in Wireless Sensor Networks (2008)

What is the fastest rate at which we can collect a stream of aggregated data from a set of wireless sensors organized as a tree? We explore a hierarchy of techniques using realistic simulation models to address this question. We begin by considering TDMA scheduling on a single channel, reducing the original problem to minimizing the number of time slots needed to schedule each link of the aggregation tree. The second technique is to combine the scheduling with transmission power control to reduce the effects of interference. To better cope with interference, we then study the impact of utilizing multiple frequency channels by introducing a simple receiver-based frequency and time scheduling approach. We find that for networks of about a hundred nodes, the use of multi-frequency scheduling can suffice to eliminate most of the interference. The data collection rate then becomes limited not by interference, but by the maximum degree of the routing tree. Therefore we consider finally how the data collection rate can be further enhanced by the use of degree-constrained routing trees. Considering deployments at different densities, we show that these enhancements can improve the streaming aggregated data collection by as much as 10 times compared to the baseline of single-channel data collection over non-degree constrained routing trees. Addition to our primary conclusion, in the frequency scheduling domain we evaluate the impact of different interference models on the scheduling performance and give topology-specific bounds on time slot and frequency channel requirements.