gebhart/patrepeval huggingface dataset:
Dithiocarbamates with potent inhibitory activity against theSaccharomyces cerevisiaeβ-carbonic anhydrase (2015)

Dithiocarbamates (DTCs) prepared from primary or secondary amines, which incorporated amino/hydroxyl-alkyl, mono-/bicyclic aliphatic/heterocyclic rings based on the quinuclidine, piperidine, hydroxy-/carboxy-/amino-substituted piperidine, morpholine and piperazine scaffolds, were investigated for the inhibition of α- and β-carbonic anhydrases (CAs, EC 4.2.1.1) of pharmacologic relevance, such as the human (h) isoform hCA I and II, as well as the Saccharomyces cerevisiae β-CA, scCA. The yeast and its β-CA were shown earlier to be useful models of pathogenic fungal infections. The DTCs investigated here were medium potency hCA I inhibitors (K(I)s of 66.5-910 nM), were more effective as hCA II inhibitors (K(I)s of 8.9-107 nM) and some of them showed excellent, low nanomolar activity against the yeast enzyme, with inhibition constants ranging between 6.4 and 259 nM. The detailed structure activity relationship for inhibition of the yeast and human enzymes is discussed. Several of the investigated DTCs showed excellent selectivity ratios for inhibiting the yeast over the human cytosolic CA isoforms.
Nanomechanics weighs in (2004)

We tend to associate mass with the quantity or size of an object. At the microscopic scale, however, mass measurements are a powerful tool that can provide information about the molecular and atomic composition of an object. While measurements of macroscopic masses traditionally rely on the fact that the gravitational force is directly proportional to the mass of the object, the Earth's gravitational field is too weak to produce reliable measurements of the force in the case of molecular-scale objects.
Microalgae growth rate multivariable mathematical model for biomass production (2022)

This work could be used in the production of microalgae biomass for the design and development of topical applications to replace commercial options based on compounds that compromise health and have a harmful impact on the environment.
Human walking estimation with radar (2003)

Radar can be used to observe humans that are obscured by objects such as walls. These humans cannot be visually observed. The radar measurements are used to animate an obscured human in virtual reality. This requires detailed information about the motion. The radar measurements give detailed information about the movements of the human body parts; the Doppler signatures are time-varying and observed in the spectrogram. The authors focus on the extraction of parameters and describe a method for estimating human walking parameters from radar measurements. The parameters are estimated by minimising the difference between a simulated model and real measurements. A human walking model is presented which can be used both to calculate the radar response and to visually animate a walking person. The method is applied to real radar measurements of inbound walking humans from a distance of 20 m. The results show that estimation of the walking parameters is possible. The animated walking human generated with estimated parameters is a realistic likeness of the real walking human.
Development of a wearable multi-sensor system for lower limb joint torque evaluation during stairs climbing (2017)

Torque control is significant for the control of the exoskeleton robot. Different from the classical Newton-Euler method, this paper introduces a novel human model during low-speed stairs climbing for estimating the lower limbs joint torque in the sagittal plane. In this model, the stair ascent gait cycle is divided into four phases: single support, double support, right leg support with left redundancy and left leg support with right redundancy, which manifest to four different models. To verify the model, IMUs and smart shoes are used to measure the joint kinematic and ground contact force. A fuzzy logic rule is proposed for gait analysis in one stair ascent gait cycle. The optical measurement system and force plates are used as a reference, of which the basic principle is the Newton-Euler method. The results of kinematic and dynamic analysis based on the model are compared with the reference through a low-speed climbing stairs experiment with different loads.
Ventricular uptake during brain scanning. A case report of ventricular lymphomatosis. [/sup 99m/Tc-stamous glucoheptonate] (1978)

Visualization of the cerebral ventricles during radionuclide brain scanning is rarely reported. A case demonstrating the lateral ventricles by brain scanning with /sup 99m/Tc-stannous glucoheptonate in a patient with lymphoma is presented.
Energetically Demanding Transport in a Supramolecular Assembly (2014)

A challenge in contemporary chemistry is the realization of artificial molecular machines that can perform work in solution on their environments. Here, we report on the design and production of a supramolecular flashing energy ratchet capable of processing chemical fuel generated by redox changes to drive a ring in one direction relative to a dumbbell toward an energetically uphill state. The kinetics of the reaction pathway juxtapose a low energy [2]pseudorotaxane that forms under equilibrium conditions with a high energy, metastable [2]pseudorotaxane which resides away from equilibrium.
Radio Frequency Impedance Interrogation monitoring of hemodynamic parameters (2011)

Non-contact, non-invasive monitoring of hemodynamic parameters has long been deemed to be important to medical monitoring in a variety of environments. Radio Frequency Impedance Interrogation (RFII) measures hemodynamic function via resonance frequency coupling to a hydrophilic protein molecule. We examined the use of RFII for hemodynamic monitoring of human subjects during Lower Body Negative Pressure (LBNP) and physiological hemodynamic maneuvers using valsalva and orthostatic position changes in this small pilot study. Results demonstrate a high degree of correlation between stroke volume waveform amplitude (R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> = 0.92) and RFII derived R-R interval (R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> = 0.99) and classic electrocardiogram (ECG). These results suggest that RFII may be of great utility in the pre-hospital triage setting and for in-hospital patient monitoring.
Supplementary Fig. S8 from Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells (2023)

Supplementary Fig. S8 from Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells
Evaluation of mTOR-Regulated mRNA Translation (2011)

mTOR, the mammalian target of rapamycin, regulates protein synthesis (mRNA translation) by affecting the phosphorylation or activity of several translation factors. Here, we describe methods for studying the impact of mTOR signalling on protein synthesis, using inhibitors of mTOR such as rapamycin (which impairs some of its functions) or mTOR kinase inhibitors (which probably block all functions).To assess effects of mTOR inhibition on general protein synthesis in cells, the incorporation of radiolabelled amino acids into protein is measured. This does not yield information on the effects of mTOR on the synthesis of specific proteins. To do this, two methods are described. In one, stable-isotope labelled amino acids are used, and their incorporation into new proteins is determined using mass spectrometric methods. The proportions of labelled vs. unlabeled versions of each peptide from a given protein provide quantitative information about the rate of that protein's synthesis under different conditions. Actively translated mRNAs are associated with ribosomes in polyribosomes (polysomes); thus, examining which mRNAs are found in polysomes under different conditions provides information on the translation of specific mRNAs under different conditions. A method for the separation of polysomes from non-polysomal mRNAs is described.
Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems. (1992)

Since human colorectal tumors are insensitive to most chemotherapeutic agents, there is a need for the discovery of new drugs that would show activity against this disease. In an attempt to better appreciate the relevance of a widely used mouse colon tumor (colon adenocarcinoma Co38) as a screening model for human colorectal tumors, we compared the main phase I and phase II drug-metabolizing enzyme systems in both tumoral and nontumoral colon tissues. The following enzymes were assayed by Western blot: cytochromes P-450 (1A1/A2, 2B1/B2, 2C, 2E1, and 3A), epoxide hydrolase, and glutathione-S-transferases (GST-alpha, -mu, and -pi). The activities of the following enzymes or cofactors were determined by spectrophotometric or fluorometric assays: total cytochrome P-450, 1-chloro-2,4-dinitrobenzene-GST, selenium-independent glutathione peroxidase, 3,4-dichloronitrobenzene-GST, ethacrynic acid-GST, total glutathione, epoxide hydrolase, UDP-glucuronosyltransferase, beta-glucuronidase, sulfotransferase, and sulfatase. Results obtained by Western blot showed that mouse colon adenocarcinoma Co38 did not express any of the probed cytochromes P-450, whereas human colorectal tumors expressed only low levels of cytochrome P-450 3A. GST-alpha and GST-pi were detected in all tumoral and nontumoral tissues of both species. The neutral GST-mu was expressed in all murine tissues investigated and was found to be polymorphic in human tissues. For human peritumoral and tumoral colorectal tissues there was no significant difference between GST isoenzyme levels, whereas mouse colon adenocarcinoma Co38 had a lower expression of GST-mu and GST-pi, compared to normal mouse colon. Enzymatic activities for glutathione peroxidase, 3,4-dichloronitrobenzene-GST, and ethacrynic acid-GST confirmed the Western blot results for GST-alpha, GST-mu, and GST-pi, respectively. Total GSH levels were similar between murine and human tumors but were 3-fold higher in human tumors than in peritumoral tissues, whereas they were 7-fold lower in mouse colon tumor Co38, compared to normal mouse colon. Epoxide hydrolase was not expressed in either mouse colon adenocarcinoma Co38 or normal mouse colon tissues, whereas it was expressed in human colon peritumoral and tumoral tissues at similar levels. No significant difference was observed between human tumors and peritumoral tissues for UDP-glucuronosyltransferase, beta-glucuronidase, sulfotransferase, and sulfatase. For murine colon tissues, the conjugation pathways (UDP-glucuronosyltransferase and sulfotransferase) were lower in colon adenocarcinoma Co38, whereas the converse was observed for the corresponding hydrolytic enzymes (beta-glucuronidase and sulfatase).(ABSTRACT TRUNCATED AT 400 WORDS)
The value of echocardiography for the assessment of the cardiac impairment in chronic renal failure in child. (2002)

Echo exam has a great utility for the diagnosis of cardiac disturbances in children with CRF, especially in cases with severe cardiac involvement and without cardiac symptoms; this investigation has to be performed right since the initial diagnosis, as well as for long-term surveillance.
About the Author (2016)

No AccessRheological and Morphological Properties of Dispersed Polymeric MaterialsJul 2016About the AuthorHelmut MünstedtHelmut MünstedtSearch for more papers by this authorhttps://doi.org/10.3139/9781569906088.020SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2016Pages: 447-447Print ISBN: 978-1-56990-607-1eISBN: 978-1-56990-608-8 Copyright & Permissions© 2016 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Focal Prostate Stereotactic Body Radiation Therapy With Correlative Pathological and Radiographic-Based Treatment Planning (2021)

On our pilot trials of f-SBRT planning using rigorous imaging and pathology concordance, image-guided confirmatory biopsies frequently revealed additional disease, suggesting the need for caution in partial-gland therapy. For truly focal disease, f-SBRT provided excellent dosimetry, minimal toxicity, and encouraging biochemical response. <b>Clinical Trial Registration</b>: www.clinicaltrials.gov, NCT02681614; NCT02163317.
Oncolytic virotherapy for multiple myeloma (2008)

Several viruses are currently being developed preclinically and clinically to treat MM, including measles virus, vesicular stomatitis virus, coxsackievirus A21 and vaccinia virus. Other viruses are being used preclinically to purge myeloma cells from autologous bone marrow transplants. Efforts to improve myeloma-specific targeting, avoid the antiviral immune response and evaluate combination therapies for MM are ongoing.
Computed Tomography of the Breast (1977)

Initial studies indicate that computed tomography can detect both benign and malignant breast disease in both fatty and dense, thick breasts. CT may also be capable of diagnosing early cancer or a precancerous lesion in women with dysplastic breasts or patients who have had radiation therapy or surgery, whereas some of these lesions cannot be diagnosed by mammography because the breast is too dense.
Comparison of Cyanex 272 and Cyanex 572 for the separation of Neodymium from a Nd/Tb/Dy mixture by pertraction (2017)

Abstract BACKGROUND Recovering Nd(III) from waste magnets is an alternative method to satisfy the increasing demand for this metal. For this reason, the separation of Nd from a mixture containing Nd/Tb/Dy in chloride media using Cyanex 272 and Cyanex 572 has been evaluated. RESULTS Using Cyanex 272 and Cyanex 572, the metals are transported in the order Dy(III) &gt; Tb(III) &gt; &gt; Nd(III) in all conditions studied. The optimum feed conditions to achieve Nd(III) separation are: Cyanex 272: pH 2 and Cyanex 572: pH 1.5 with 1.2 mol L ‐1 HCl as a receiving agent for both carriers. CONCLUSION The results obtained suggest that Cyanex 572 is a better carrier than Cyanex 272 for separating Nd(III) from a mixture containing Nd/Tb/Dy. © 2017 Society of Chemical Industry
Fabrication Micro-Nozzle Plates for Inkjet Print Head Using LIGA Process (2008)

This paper presents a novel LIGA-like process to fabricate the nozzle plate for matching the requirements of the 600 dpi inkjet printhead. This novel fabrication technique reduces the production cost from 100% current process to 50%. This mass production technique comprises two main technologies: Ni-Co electroforming and plastic injection molding. The nozzle plate consists ink channels, ink cavities, and nozzles for enhancing the integrity and excusing the assembly process. The dimensions of nozzle plate are 4.16mm in width and 7.3mm in length, respectively. Total thickness of micro-nozzle plates are thickness≦100um(ink channels and ink cavities), and the diameter and pitch of the nozzle holes are 40±3um and 168±3 um, respectively. Straightly speaking, for being the main compositions of the 600 dpi inkjet printhead design, the above fabrication process is qualified enough and capable of yielding satisfactory results.
Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. (1996)

We have shown previously that chronic exposure of HIT-T15 cells to supraphysiologic glucose concentrations causes decreased insulin gene transcription and decreased binding activities of two beta-cell specific transcription factors, STF-1 and the RIPE3b1 activator, and have suggested that these events may provide a mechanism for glucose toxicity on beta-cell function. However, this contention can be criticized because it is not clear whether these observations are unique to the HIT-T15 cell or generalizable to other beta-cell lines and the islet. Therefore, we cultured betaTC-6 cells for up to 41 wk in either 11.1 or 0.8 mM glucose. We observed a passage-dependent decrease in insulin content and insulin mRNA levels in betaTC-6 cells chronically cultured in 11.1 mM glucose. Cells chronically cultured in 0.8 mM glucose had higher insulin mRNA levels than cells chronically cultured in 11.1 mM glucose. The relative activity of a chloramphenicol acetyl transferase (CAT) reporter gene controlled by the 5' regulatory region of the human insulin gene was decreased in late passage betaTC-6 cells chronically cultured in 11.1 mM glucose, but was preserved in late passages of cells chronically cultured in 0.8 mM glucose. Electromobility shift assays demonstrated that binding of a specific nuclear protein that recognizes the RIPE3b1 binding site of the insulin gene was markedly diminished in late passage cells chronically exposed to 11.1 mM glucose, whereas binding activities of STF-1 and ICE activators were unchanged. RIPE3b1 binding activity was preserved in late passage cells chronically exposed to 0.8 mM glucose. Mutation of the RIPE3b1 binding site almost completely abolished insulin gene transcription as well as binding activity. We conclude that chronic exposure of betaTC-6 cells to high glucose concentrations paradoxically decreases insulin gene transcription, in part, by decreasing activity of the trans-activating factor which binds to the RIPE3b1 sequence. This study uniquely demonstrates that altered binding to the RIPE3b1 sequence mediates glucose toxicity in betaTC-6 cells, thus reinforcing the importance of this cis-acting element in the regulation of insulin gene transcription. We conclude that the phenomenon of glucose toxicity decreasing binding of transcription factors and thereby reducing insulin gene expression is not a feature solely of HIT-T15 cells and may be demonstrable generally in beta-cell lines.
Titanium disilicide contact resistivity and its impact on 1-&#181;m CMOS circuit performance (1987)

A major feature of modern 1-µm CMOS technology is the use of TiSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -clad diffusions with effective sheet resistances of typically 1 Ω /square. However, until now very little attention has been given to the contact resistance between the TiSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> and the underlying diffusions which form the source and drain of the active transistors. Our experimental results have shown that, depending on process conditions, the specific contact resistivity from silicide to n-diffusion varies by six orders of magnitude. In this work it is demonstrated that unless proper care is taken with respect to junction doping concentrations and post-silicide processing to minimize the silicide to diffusion contact resistance, the use of silicided diffusions actually can be detrimental to circuit performance instead of the intended performance enhancement. In this paper we will present: 1) a novel method to evaluate silicide to diffusion contact resistance using only two masks, 2) an outline of the process conditions that yield a minimum contact resistance, 3)circuit simulations showing the impact of this work on circuit performance, and 4) results showing that the modulation of the contact resistance at high current levels can distort the MOS linear region current-voltage characteristics.
Chronic Infusion of Low Doses of Atrial Natriuretic Factor (ANF Arg 101-Tyr 126) Reduces Blood Pressure in Conscious SHR without Apparent Changes in Sodium Excretion (1985)

Conscious SHR and WKY rats were infused during 7 days with synthetic ANF (Arg 101-Tyr 126), 100 ng/hr/rat (35 pmol/hr/rat) by means of miniosmotic pumps. The SHR initial blood pressure of 177 +/- 5 mmHg gradually dropped to 133 +/- 3 and 142 +/- 4 mmHg the last two days of infusion. No significant change in blood pressure was observed in the ANF-infused WKY group. No apparent difference in natriuresis or diuresis was observed in ANF-infused SHR and WKY when compared with non-infused control groups. A slight but significant lower immunoreactive ANF concentration was found in the atria of SHR than in their normotensive controls. No difference in cardiac weight was found between infused and non-infused rats. It is suggested that the hypotensive response observed in SHR and not in WKY is due to a decrease in vascular peripheral resistance. Whether ANF is involved in the development and maintenance of high blood pressure in SHR remains to be elucidated.
Optical-Phonon Assisted Tunneling in an Asymmetric Double-Quantum-Well Structure (1997)

Electroreflectance (ER), time-integrated photoluminescence (PL) and time-resolved PL experiments were performed on an Al0.36Ga0.64As/GaAs asymmetric double-quantum well (ADQWs) structure with coupled narrow and wide quantum wells in order to investigate the optical-phonon assisted tunneling. At a certain external applied voltage, a distinct quenching of the time-integrated PL intensity for the narrow quantum well is observed. By calibrating the internal electric field through the ER measurements and calculating subband levels in the ADQWs structure, the quenching is attributed to the resonant optical-phonon assisted tunneling of electrons between the narrow and wide quantum wells. The decay time of electrons in the narrow quantum well was also found to become minima at the same applied voltage.
Sub-60 °C atmospheric helium–water plasma jets: modes, electron heating and downstream reaction chemistry (2011)

For plasma treatment of many heat-labile materials (e.g. living tissues) that either are moist or contain a surface layer of liquid, it is desirable that the gas plasma is generated at atmospheric pressure for process convenience and with a gas temperature ideally no more than 60 °C for mitigating permanent damage to the integrity of the test material. This implies that the liquid-containing plasma needs to be of low dissipated electrical energy and that plasma treatment should be based largely on non-equilibrium reaction chemistry. In this paper, a class of sub-60 °C atmospheric helium–water plasma jets is studied in terms of their main physiochemical properties. It is shown that there are five distinct modes appearing in the sequence of, with increasing voltage, the first chaotic mode, the plasma bullet mode, the second chaotic mode, the abnormal glow mode and the non-thermal arc mode. Its chaotic modes may be sustained over a wide range of water vapour concentrations (0–2500 ppm). Compared with other liquid-containing plasmas, the He–H 2 O plasma jet operated below its non-thermal arc mode has several distinct advantages, namely very low energy consumption (2–10 µJ per pulse), sub-60 °C gas temperature, electron-modulated production of He, N 2 , , O * , H and OH( A – X ), and low ozone production (0.1–0.4 ppm). These results provide a first attempt at the landscape of the physiochemical characteristics in atmospheric He–H 2 O plasma jets.