gebhart/patrepeval huggingface dataset:
Evaluation of intrauterine immune suppression during pregnancy in a species with epitheliochorial placentation. (1987)

Cells capable of suppressing the immune response of PBL to the mitogen PHA are associated with the epitheliochorial placenta during normal first pregnancy in the pig. Because placentation in the pig is noninvasive, these suppressor cells are not associated with decidua. Cells with similar activity are also found between the implantation sites and in the uterus of pseudopregnant pigs, suggesting that fetal trophoblast is not essential for recruitment of intrauterine suppressor cells. Cell separation studies demonstrate that two independent populations of suppressor cells are present in the pig uterus on day 28 of gestation, as well as a population of PHA-responsive cells. The inability of unseparated porcine uterine cells to respond to PHA, plus the reconstitution of suppression in remixing experiments, demonstrate directly that a functional, putative T effector cell population is blocked within the uterus during normal mammalian pregnancy.
Structural principles of parallel beta-barrels in proteins. (1988)

Eight-stranded beta-sheets in nine protein structures containing "TIM (triose phosphate isomerase) barrels" are shown to be fitted satisfactorily by hyperboloids, the generating lines of which pass through the beta-strands. Simple parameterizations of the hyperboloid model are then used to determine the constraints that govern key parameters, such as the number of strands in the barrel, and to rationalize the remarkable conservation of strand number, observed to be eight, in nearly all the known examples of parallel beta-barrels. It is shown that the requirement to exclude solvent from the barrel interior, while at the same time keeping an upper limit on strand twist and interstrand distance so as to foster extensive hydrogen bonding interactions within the sheet, imposes strong constraints on barrel geometry. A formal description of the relationships between beta-sheet twist, strand number, and barrel dimensions is given here. It could have important implications for studies of protein folding and design.
Diversification of Nonionic Amphiphilic Poly(N-vinylacetamide) Hydrogels by a Double Network Approach (2007)

Abstract The amphiphilic aprotic vinyl monomer, N-vinylacetamide (NVA), was firstly employed to fabricate double network (DN) hydrogels in water at 37 °C. Although N,N-methylenebisacrylamide as a crosslinker did not form hydrogels, novel crosslinker which is based on the structure of NVA was effective in creating first and second network hydrogels. DN structures of nonionic NVA hydrogels will expand the pool of various functional hydrogels, as well as give rise to stronger NVA hydrogel preparations.
ChemInform Abstract: THE ALKYL HALIDE CATALYZED PSEUDOMOLECULAR REARRANGEMENT OF IMIDATES TO AMIDES‐ AN EXPLANATION FOR THE AMBIDENT NUCLEOPHILIC PROPERTIES OF NEUTRAL AMIDES (1978)

Abstract Die Thermolyse der Benzimidate (Ia) in Nitrobenzol in Gegenwart der entsprechenden Alkyliodide (IIa) ergibt in pseudomolekularer Reaktion über die intermediären Benzimidoniumionen die tertiären Amide (IIIa).
Heavy-Ion Radiography: Density Resolution and Specimen Radiography (1978)

Heavy-ion radiography is performed by the passage of a beam of nuclei accelerated to energies of several hundred MeV/nucleon through an object. The technique of recording transmitted nuclei in a downstream stack of plastic sheets affords excellent resolution of density by recording the nuclei only at their stopping points. Imaging of a phantom--which stimulated tumors of low density contrast in a body part--by conventional radiography, computed tomographic scanning and the heavy-ion technique indicated superior density resolution for heavy-ion imaging at radiation dose. Superior imaging of tumors in pathologic specimens was demonstrated for heavy-ion imaging compared to conventional radiography. Values of stopping power for various tumors and normal tissues were determined by a computer-aided technique. Heavy-ion radiography shows promise for superior imaging of low contrast tumors at relatively low radiation low levels.
Ex-situ and in-situ Microscopy Study of ZrO 2 -stabilized Pd/Al 2 O 3 Catalysts (2016)

Stability issues are of great importance in emissions-control catalysis, in which high temperatures and redox cycling can lead to severe deactivation due to coarsening of metal catalyst particles. Supported Pd is the one of the most widely used catalysts for methane oxidation, and contact between Pd and some oxides, such as CeO 2 , is known to promote the reaction. Further, encapsulation of Pd particles by thin shells of these oxides (e.g., Pd@CeO 2 ) has been found to provide good thermal stability [1]. Alternatively, the deposition of thin overlayers of the oxide onto a supported metal catalyst by atomic layer deposition (ALD) has proven to be an equally effective, though simpler way to both stabilize Pd at high temperature and enhance catalytic activity [2]. In this work, we use atomic scale Scanning Transmission Electron Microcopy (STEM) and Energy Dispersive Spectroscopy (EDS) to study the spatial distribution of a very thin ZrO 2 overlayer deposited by ALD onto high-surface-area aluminasupported Pd. The stability of the ZrO 2 overlayer was also examined by dynamic in-situ microscopy, conducted at 150 Torr O 2 at elevated temperatures.
Direct Light Pattern Integration of Low-Temperature Solution-Processed All-Oxide Flexible Electronics (2014)

The rise of solution-processed electronics, together with their processing methods and materials, provides unique opportunities to achieve low-cost and low-temperature roll-to-roll printing of non-Si-based devices. Here, we demonstrate a wafer-scale direct light-patterned, fully transparent, all-solution-processed, and layer-by-layer-integrated electronic device. The deep ultraviolet irradiation of specially designed metal oxide gel films can generate fine-patterned shapes of ∼3 μm, which easily manifest their intrinsic properties at low-temperature annealing. This direct light patterning can be easily applied to the 4 in. wafer scale and diverse pattern shapes and provides feasibility for integrated circuit applications through the penetration of the deep ultraviolet range on the quartz mask. With this approach, we successfully fabricate all-oxide-based high-performance transparent thin-film transistors on flexible polymer substrates.
ChemInform Abstract: Highly Efficient Asymmetric Amination of β‐Keto Esters Catalyzed by Chiral Quaternary Ammonium Bromides. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
L5 luciferase reporter mycobacteriophages: a sensitive tool for the detection and assay of live mycobacteria (1995)

Recombinant bacteriophages provide efficient delivery systems for introducing reporter genes into specific bacterial hosts. We have constructed mycobacteriophage L5 recombinants carrying the firefly luciferase gene inserted into the tRNA region of the phage genome. Infection of Mycobacterium smegmatis by these phages results in expression of the luciferase gene and light emission. Fortuitously, the luciferase gene is expressed continuously in lysogens surviving infection. Synthesis of luciferase from a mycobacterial promoter created by cloning enables the detection of extremely small numbers of M. smegmatis cells. These reporter phages can be used to discriminate between drug-sensitive and drug-resistant strains of M. smegmatis, and may provide tools for the rapid identification and classification of antimycobacterial agents.
Towards Systems Biology of Human Pulmonary Fibrosis (2007)

The integrated effect of multiple pathways, molecules, genetic polymorphisms, environmental stimuli, and possible infection determines the lung phenotype in idiopathic pulmonary fibrosis (IPF), a chronic progressive and often lethal lung disease. Systems biology approaches aim to provide a systemwide view of biological process using computational tools and high-throughput technologies. Although much of the analysis of genome-level transcriptional high-resolution profiles of IPF was reductionist, usually focusing on a single factor in the disease process, there are some studies that implement systems approaches. We discuss these analyses and provide examples of the global analysis of IPF, hypersensitivity pneumonitis, and nonspecific interstitial pneumonia. Detailed quantitative phenotyping and correlation with microarray results as well as high-throughput genotyping should provide us with the datasets to implement systems biology approaches in fibrosis research. Interdisciplinary teams and training of junior investigators in the vocabulary of systems biology should allow us to use these datasets integratively and generate a global model of human pulmonary fibrosis.
The effects of an integrated supportive care intervention on quality of life outcomes in outpatients with breast and gynecologic cancer undergoing chemotherapy: Results from a randomized controlled trial (2019)

The aim of the Complementary Nursing in Gynecologic Oncology study was to investigate the effects of a complex, nurse-led, supportive care intervention using Complementary and Integrative Medicine (CIM) on patients' quality of life (QoL) and associated patient-reported outcomes. In this prospective, pragmatic, bicentric, randomized controlled trial, women with breast or gynecologic cancer undergoing a new regimen of chemotherapy (CHT) were randomly assigned to routine supportive care plus intervention (intervention group, IG) or routine care alone (control group, CG). The intervention consisted of CIM applications and counseling for symptom management, as well as CIM information material. The primary endpoint was global QoL measured with the EORTC-QLQ-C30 before and after CHT. Mixed linear models considering fixed and random factors were used to analyze the data. In total, 126 patients were randomly assigned into the IG and 125 patients into the CG (median age 51 years). The patients' medical and socio-demographic characteristics were homogenous at baseline and at follow-up. No group effects on QoL were found upon completion of CHT (estimate -1.04 [-4.89; 2.81]; P = 0.596), but there was a significant group difference in favor of the IG 6 months later (estimate 6.643 [1.65; 11.64]; P = 0.010). IG patients did also experience significant better emotional functioning (P = 0.007) and less fatigue (P = 0.027). The tested supportive intervention did not improve patients' QoL outcomes directly after CHT (T3), but was associated with significant QoL improvements when considering the change from baseline to the time point T4, which could be assessed 6 months after patients' completion of CHT. This delayed effect may have resulted due to a strengthening of patients' self-management competencies.
Time-Lock Puzzles from Randomized Encodings (2016)

Time-lock puzzles are a mechanism for sending messages "to the future". A sender can quickly generate a puzzle with a solution s that remains hidden until a moderately large amount of time t has elapsed. The solution s should be hidden from any adversary that runs in time significantly less than t, including resourceful parallel adversaries with polynomially many processors.
Facile Deposition of Mesoporous PbI2 through DMF:DMSO Solvent Engineering for Sequentially Deposited Metal Halide Perovskites (2020)

Sequential deposition is one of the most promising approaches toward achieving scalable fabrication of metal halide perovskite thin films. However, this fabrication approach conventionally lends itself to the incomplete conversion of the lead halide, which impacts the stability, performance, and reproducibility of functional devices featuring such thin films. In this work, we have overcome this limitation by using a simple solvent and process engineering approach. We show that through the use of an optimized dimethylformamide and dimethyl sulfoxide solvent mixture in the precursor solution, and through the judicious control of this solution, the substrate, and final annealing temperatures, highly uniform and mesoporous PbI2 thin films can be deposited. The porous structure of these films is found to accelerate the interdiffusion of CH3NH3I (MAI) during the second-step process when carried out at room temperature, enabling their complete conversion into CH3NH3PbI3 perovskite. Detailed investigations using scanning electron microscopy, X-ray diffraction, grazing-incidence wide-angle X-ray scattering, thermogravimetric analysis, UV–vis absorption, photoluminescence, and time-of-flight secondary ion mass spectrometry have been used to provide mechanistic insights into the porous PbI2 film formation and the interdiffusion process. Solar cells based on planar fluorine-doped tin oxide (FTO)/TiO2/CH3NH3PbI3/spiro-OMeTAD/Au device architectures yield optimized device efficiencies of 19%, which is among the highest for this device structure and perovskite absorber material. The applicability of this enhanced sequential deposition method to other perovskite systems has been further validated through the fabrication of efficient FAxMA1–xPbIxBr3–x and CsPbIxBr3–x solar cells.
Design Studies for Quarter-Wave Resonators and Cryomodules for the Riken SC-LINAC (2015)

Recently we proposed a new project aimed at intensity upgrade of uranium beams of RIKEN RIBF. In this new project, construction of a superconducting linac is planned replacing the injector cyclotron so called RRC. The RIKEN superconducting linac consists of 14 cryomodules each of which contains four quarter-wave-resonators (QWRs) in each. The QWR operates at an rf frequency of 73 MHz in the continuous wave mode with beta as low as 0.055-1.008. A coaxial probe-type RF fundamental power-coupler which transmits RF power of several kW will be utilized for beam loading of 1.3 kW/resonator at the maximum with Qext of several x10⁶. Tuning of the resonant frequency will be realized with a mechanical tuner pressing the resonator wall in the direction parallel to the beam. This year, we started a development of a test cryomodule with SC-QWRs. In this paper, design studies for a SC-QWR and its cryomodule, e.g., QWR, coupler, and, tuner will be presented together with a construction schedule of the prototype. Prototyping of a superconducting cavity and its test cryomodule was funded by ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan).
Sustained release of buserelin acetate, a luteinizing hormone-releasing hormone agonist, from an injectable oily preparation utilizing ethylated β-cyclodextrin (1989)

The possible use of heptakis (2,6-di-O-ethyl)-beta-cyclodextrin (DE-beta-CyD) as a parenteral sustained-release carrier for buserelin acetate, a luteinizing hormone-releasing hormone superagonist, has been examined. The in-vitro release of buserelin from the oily suspension was significantly retarded by the complexation with DE-beta-CyD, mainly due to the poor water solubility of the complex. A single subcutaneous injection of the suspension containing the buserelin-DE-beta-CyD complex to rats provided an effective continuous plasma level of buserelin lasting for at least one month, indicating a potential therapeutic efficacy for the treatment of the endocrine-dependent diseases. These results suggest that DE-beta-CyD serves as an injectable sustained-release drug carrier suitable for chronic treatment with buserelin acetate.
Supplementary Figure 1 from Evolutionary Approaches to Prolong Progression-Free Survival in Breast Cancer (2023)

&lt;p&gt;PDF file - 41K, Computational model of competition between drug sensitive and PGP+ mutants&lt;/p&gt;
Intestinal expression of human apolipoprotein A-IV in transgenic mice fails to influence dietary lipid absorption or feeding behavior. (1994)

Two transgenic mouse lines, expressing low or high amounts of human apo A-IV were created. In low and high expressor HuAIVTg mice on a chow diet, serum human apo A-IV levels were 6 and 25 times the normal human level and on a high fat diet, they were 12 and 77 times higher. Human apo A-IV was equally distributed between lipoprotein (mainly HDL) and lipid-free fractions. Intestinal absorption of radiolabeled cholesterol and triglycerides was unaffected in HuAIVTg mice. Vitamin A, carried exclusively in chylomicrons and their remnants, was catabolized normally. When an intragastric vitamin E bolus is given to the HuAIVTg mice, the initial absorption and appearance in triglyceride-rich lipoproteins was similar to that observed in normal mice. However, elevated amounts of vitamin E were subsequently observed in the VLDL of the HuAIVTg mice. Furthermore, in the fed state, serum VLDL triglycerides were markedly elevated in HuAIVTg mice. This effect was greater in high expressor mice. Serum total cholesterol was not elevated, but the distribution was altered in the HuAIVTg mice; VLDL-C was increased at the expense of VLDL-C. Kinetic studies suggested a delayed clearance of VLDL in HuAIVTg mice. Apo A-IV has been suggested to be a satiety factor, but no effect on feeding behavior or weight gain was observed in these HuAIVTg mice. In summary, our studies with HuAIVTg mice show that additional apo A-IV does not effect intestinal absorption of fat and fat-soluble vitamins, and at least chronic elevation of plasma apo A-IV does not effect feeding behavior in this model system.
A Grand Canonical Monte-Carlo Simulation of the Textural, Mechanical and Adsorption Properties of Faujasite zeolite Carbon Replica (2006)

In this work, we present a Grand Canonical Monte-Carlo simulation results for the adsorption of carbon vapour in the pores of faujasite zeolite (in its siliceous form). The carboncarbon interactions are described within the frame of a Tight Binding approach (fourth momentum’s method) while the carbon-zeolite interactions are modelled using a PN-TrAZ physisorption potential. Siliceous faujasite allows obtaining a 3D connected porous material. The intrinsic stability of such carbon nanostructures was also investigated after removal of the inorganic phase, for there mechanical properties, and there gas adsorption properties. We also have shown that the replica hydrostatic mechanical properties are much better compared to the zeolite and with a very low density. The comparison of the calculated structure factor with experimental studies has given a criterium to characterize the perfect replica. Therefore, we calculated the pore size distribution (PSD) offering to experiments a precision more.
Semiconductor properties of polyphosphides (1984)

For the first time, the electro-optical properties of nontetrahedrally bonded crystalline and amorphous polyphosphides have been investigated. The crystalline archetype KP15 is a high resistivity semiconductor, with photoconductivity and photoluminescence at the band gap (1.7 eV). These measurements are extended to amorphous films prepared by vapor transport methods. The resistivity of the films has been varied over eight orders of magnitude by the incorporation of 0%–2% Ni. Nonlinear metal-semiconductor behavior with good current carrying capability (1 A/cm2) has been observed. When deposited on InP, the films reduce the density of surface states in metal-insulator-semiconductor diodes to ∼1010/cm2 eV, probably by providing continuity to the group V element at the interface. It is concluded that the low crystal symmetry of polyphosphides leads to a significant new amorphous semiconductor in which the electronic coherence length is commensurate with the intermediate range order.
Coadsorption of hydrocarbons and water on BPL activated carbon (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoadsorption of hydrocarbons and water on BPL activated carbonEdgar N. Rudisill, John J. Hacskaylo, and M. Douglas LeVanCite this: Ind. Eng. Chem. Res. 1992, 31, 4, 1122–1130Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/ie00004a022https://doi.org/10.1021/ie00004a022research-articleACS PublicationsRequest reuse permissionsArticle Views727Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Copper‐Catalyzed Trifluoromethylation of N,N‐Dialkylhydrazones (2013)

Mild and practical: Trifluoromethylation of (hetero)aromatic aldehyde N,N-dialkylhydrazones was achieved at room temperature by using Togni's trifluoromethylation reagent under CuCl catalysis (see scheme). This simple reaction is believed to occur by a CF3-radical-transfer mechanism and yields useful trifluoromethylated building blocks. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Evaluation of adenomyosis after gonadotrophin-releasing hormone agonist therapy using ultrasound post-processing imaging: a pilot study (2020)

Computer-aided image analysis of grayscale histograms of the myometrium obtained from ultrasound images is an alternative method for assessing myometrial conditions after GnRH agonist treatment in patients with adenomyosis.