gebhart/patrepeval huggingface dataset:
An N-Path Enhanced-Q Tunable Filter With Reduced Harmonic Fold Back Effects (2013)

A high-Q, tunable, bandpass filtered amplifier structure is proposed which is based on a novel Q enhancement technique in N-path filters. Using Fourier series analysis, frequency response of an N-path filter as well as the aliasing effects which are present in it are derived. Frequency translation of unwanted contents at higher frequencies to the center frequency of the bandpass filter is called harmonic fold back (HFB). It is shown that using an additional N-path filter with the same clock frequency but different clock phases can reduce the HFB. The required conditions for fold back elimination are derived from Fourier series expansion analysis. In order to achieve HFB reduction as well as increasing stop-band rejection and Q factor, an LNA containing an N-path filter is added to each of the two filters. The LNA in the proposed structure is designed for high linearity and low NF, utilizing noise and distortion cancellation methods. The filter is designed and simulated in 0.18 um CMOS with an ideal balun. The voltage gain is 17.5 dB across the 0.25-1 GHz frequency band, while achieving a NF between 2.2 to 2.4 dB, an IIP3 between -2 to +2 dBm, HFB attenuation of between 25 to 45 dB and power consumption of 4.5 mW for each LNA. Finally, the proposed filter (with 4-path sub-filters) is simulated and compared to filters with 4-path and 8-path sub-filters without the proposed built-in HFB reduction.
EFFECT OF HYSTERECTOMY ON THE LIFE-SPAN OF CORPORA LUTEA INDUCED ARTIFICIALLY IN PROGESTERONE-TREATED EWES (1966)

The normal periodicity of the oestrous cycle in sheep is not significantly altered when the formation of additional corpora lutea is induced during the luteal phase by the administration of gonadotrophic hormones (Casida, Dutt &amp; Meyer, 1945). It has been established by Inskeep, Oloufa, Pope &amp; Casida (1963) that such artificially induced corpora lutea become fully functional, but regress prematurely at the time of involution of the naturally formed corpus luteum. The life-span of induced corpora lutea is even more restricted, however, when they are formed in ewes that have previously been treated with exogenous progesterone for an extended period of time (Inskeep, Howland, Pope &amp; Casida, 1964a). As a result of their studies Inskeep et al. (1963, 1964a, b) concluded that the life-span of artificially induced corpora lutea is dependent upon the level of
Enhanced Oral Bioavailability of Curcumin via a Solid Lipid-Based Self-Emulsifying Drug Delivery System Using a Spray-Drying Technique (2011)

In this study, a novel liquid self-emulsifying drug delivery system (SEDDS) containing curcumin was formulated and further developed into a solid form by a spray drying method using Aerosil 200 as the solid carrier. The optimum liquid SEDDS consisted of Lauroglycol Fcc, Labrasol and Transcutol HP as the oil phase, the surfactant and the co-surfactant at a weight ratio of 15.0 : 70.8 : 14.2 (w/w/w), respectively. There was no difference in droplet size between the emulsions obtained from the liquid and solid forms of SEDDS. Solid state characterization of the solid SEDDS was performed by scanning electron micrograph (SEM), differential scanning calorimetry (DSC), and X-ray powder diffraction (XRPD). The drug formulated in the solid SEDDS was quickly and completely dissolved within 5 min, both in 0.1 N HCl and phosphate buffer pH 6.8 dissolution media, whereas crude curcumin powder was significantly less dissoluble. The solid SEDDS formulation was stable for at least 3 months at 40°C with 75% relative humidity. After oral administration to rats, curcumin in the solid SEDDS resulted in significant improvement in in vivo absorption compared with that of curcumin powder. As the dose of curcumin formulated in solid SEDDS increased from 25 to 100 mg/kg, the C(max) and area under the drug concentration time curve (AUC) of curcumin were increased by 4.6 and 7.6 times, respectively. However, the over-proportional increase in the AUC in the higher dose group might be due to underestimation of AUC in the lower dose group. In conclusion, this solid SEDDS is a promising solid dosage form for poorly water-soluble curcumin.
Reactive GRASP: An Application to a Matrix Decomposition Problem in TDMA Traffic Assignment (2000)

A greedy randomized adaptive search procedure (GRASP) is a metaheuristic for combinatorial optimization. In this paper, we describe a GRASP for a matrix decomposition problem arising in the context of traffic assignment in communication satellites. We review basic concepts of GRASP: construction and local search algorithms. The local search phase is based on the use of a new type of neighborhood defined by constructive and destructive moves. The implementation of a GRASP for the matrix decomposition problem is described in detail. Extensive computational experiments on literature and randomly generated problems are reported. Moreover, we propose a new procedure Reactive GRASP, in which the basic parameter that defines the restrictiveness of the candidate list during the construction phase is self-adjusted according to the quality of the solutions previously found. The approach is robust and does not require calibration efforts. On most of the literature problems considered, the new Reactive GRASP heuristic matches the optimal solution found by an exact column-generation with branch-and-bound algorithm.
A new approach for event detection based on energy functions (2014)

This paper proposes a novel framework for event detection based on energy functions. The key idea is that any event (or disturbance) in the system will leave a signature (like a fingerprint) in Wide Area Measurement Systems (WAMS) data-sets. We show that signatures for four broad classes of disturbance events are buried in the components that constitute the energy function for the system. This establishes a direct correspondence (or mapping) between an event and certain component(s) of the energy function. Dynamic states required to compute the energy function are estimated with a particle filter. The estimated states along with wide-area phasor information from PMUs is used to reconstruct the components of the energy function. The individual components of the energy function are tracked dynamically and the sensitivity of these components is used to detect a disturbance in the system. Results show promising distinction between signatures of different events.
Modeling Medical Devices for Plug-and-Play Interoperability (2007)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007.
All this QE, so why no inflation? : comment (2016)

It's one of those arcane words that has emerged as part of debris from global financial crisis (GFC), and has now become a part of lexicon of man on street: 'Quantitative Easing' (QE). However, despite trillions and trillions of dollars' worth of QE, there are no signs that inflation is becoming unmanageable, never mind developing into the sum of all fears for any central banker: hyper-inflation.
Using high-order harmonics with momentum imaging techniques to study atomic and molecular dynamics (2007)

We use high harmonics in conjunction with coincidence momentum imaging (COLTRIMS) techniques to study simple molecules like CO, CO2 and N2. We explore the dynamics near the double ionization threshold using EUV/IR pump/probe techniques.
A Unified Graphics Rendering Pipeline for Autostereoscopic Rendering (2007)

Autostereoscopic displays require rendering a scene from multiple viewpoints. The architecture of current-generation graphics processors are still grounded in the historic evolution of monoscopic rendering. In this paper, we present a novel programmable rendering pipeline that renders to multiple viewpoints in a single pass. Our approach leverages on the computational and memory fetch coherence of rendering to multiple viewpoints to achieve significant speedup. We present an emulation of the principles of our pipeline using the current-generation GPUs and present a quantitative estimate of the benefits of our approach. We make a case for the new rendering pipeline by demonstrating its benefits for a range of applications such as autostereoscopic rendering and for shadow map computation for a scene with multiple light sources.
Metallaindenes of Molybdenum, Tungsten, and Ruthenium (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetallaindenes of Molybdenum, Tungsten, and RutheniumJing Yang, Jianguo Yin, Khalil A. Abboud, and W. M. JonesCite this: Organometallics 1994, 13, 3, 971–978Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/om00015a034https://doi.org/10.1021/om00015a034research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
GSK3 takes centre stage more than 20 years after its discovery (2001)

Identified originally as a regulator of glycogen metabolism, glycogen synthase kinase-3 (GSK3) is now a well-established component of the Wnt signalling pathway, which is essential for setting up the entire body pattern during embryonic development. It may also play important roles in protein synthesis, cell proliferation, cell differentiation, microtubule dynamics and cell motility by phosphorylating initiation factors, components of the cell-division cycle, transcription factors and proteins involved in microtubule function and cell adhesion. Generation of the mouse knockout of GSK3beta, as well as studies in neurons, also suggest an important role in apoptosis. The substrate specificity of GSK3 is unusual in that efficient phosphorylation of many of its substrates requires the presence of another phosphorylated residue optimally located four amino acids C-terminal to the site of GSK3 phosphorylation. Recent experiments, including the elucidation of its three-dimensional structure, have enhanced our understanding of the molecular basis for the unique substrate specificity of GSK3. Insulin and growth factors inhibit GSK3 by triggering its phosphorylation, turning the N-terminus into a pseudosubstrate inhibitor that competes for binding with the 'priming phosphate' of substrates. In contrast, Wnt proteins inhibit GSK3 in a completely different way, by disrupting a multiprotein complex comprising GSK3 and its substrates in the Wnt signalling pathway, which do not appear to require a 'priming phosphate'. These latest findings have generated an enormous amount of interest in the development of drugs that inhibit GSK3 and which may have therapeutic potential for the treatment of diabetes, stroke and Alzheimer's disease.
Three-dimensional diagnostics in air and water by molecular tagging and molecular scattering (1996)

Molecular-based approaches are particularly well suited to three-dimensional flow field diagnostics. Images simultaneously capture a wide range of scales and give both vector and scalar quantities. The diagnostic approaches discussed here include flow tagging by RELIEF and PHANTOMM in air and water, respectively; planar imaging in air with Rayleigh Scattering and Filtered Rayleigh Scattering; and planar imaging in water with Laser-Induced Fluorescence. For the tagging approaches, images can be captured using a stereoscopic camera pair to observe the threedimensional displacement of patterns written into the flow field. In the case of Rayleigh Scattering and Laser-Induced Fluorescence, three-dimensional images are captured by sequential or simultaneous images of planar cross sections through the three-dimensional volume. The visualization of these three-dimensional volume data sets requires transparent reprojection, preferably with partial obscuration and motion, if the full complex structure is to be visualized.
Prodduction of clone secretor of antibodies (IgG) againt of infection bursal disease virus. (2015)

ABSTRACT. Marín S.Y., dos Santos B.M., Patarroyo J.H. &amp;amp; Vargas M.I. [Prodduction of clone secretor of antibodies (IgG) againt of infection bursal disease virus.] Produção de clones secretores de anticorpos (IgG) contra o vírus da doença infecciosa bursal. Revista Brasileira de Medicina Veterinária, 37(2):238-144, 2015. Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Viçosa, Avenida PH Rolfs, s/n, Viçosa, MG 36570- 000, Brasil. E-mail: bmsantos@ufv.br Three clones secreting of antibodies (Abs) IgG against infection bursal disease virus IBDV was development. The IBDV was strain S706 (the intermediate vaccine) was replicated in VERO cell and purified by sucrose gradient, for ELISA and mice inoculation. For the immunization of the mice BALB/c using as a saponin adjuvant, that allowed an inflammation reaction which enhanced the antibody response, detectable by ELISA. The fusion of splenic cells of the immunized mice and the mieloma SP2/0 resulted in 2 hybridoma families (2H11 and 5C7). After cloning by limiting dilution, 3 clones secretors of Abs from IgG class were obtained. The 3 obtained Abs were capable to reveal the proteins turn VPX and VP2 by “western blotting”, respectively of 47 kDa and 41 kDa. The definition of the isotypes recognized by obtained Abs must be object of characterization to allow the use of the antibodies in immunodiagnostic tests such as immunofluorescence, immunocitochemistry or capture ELISA, for epidemiologic of the disease researches or to differentiate vaccine’s virus of the field virus.
Loss of α-Catenin Decreases the Strength of Single E-cadherin Bonds between Human Cancer Cells (2009)

The progression of several human cancers correlates with the loss of cytoplasmic protein alpha-catenin from E-cadherin-rich intercellular junctions and loss of adhesion. However, the potential role of alpha-catenin in directly modulating the adhesive function of individual E-cadherin molecules in human cancer is unknown. Here we use single-molecule force spectroscopy to probe the tensile strength, unstressed bond lifetime, and interaction energy between E-cadherins expressed on the surface of live human parental breast cancer cells lacking alpha-catenin and these cells where alpha-catenin is re-expressed. We find that the tensile strength and the lifetime of single E-cadherin/E-cadherin bonds between parental cells are significantly lower over a wide range of loading rates. Statistical analysis of the force displacement spectra reveals that single cadherin bonds between cancer cells feature an exceedingly low energy barrier against tensile forces and low molecular stiffness. Disassembly of filamentous actin using latrunculin B has no significant effect on the strength of single intercellular E-cadherin bonds. The absence of alpha-catenin causes a dominant negative effect on both global cell-cell adhesion and single E-cadherin bond strength. These results suggest that the loss of alpha-catenin alone drastically reduces the adhesive force between individual cadherin pairs on adjoining cells, explain the global loss of cell adhesion in human breast cancer cells, and show that the forced expression of alpha-catenin in cancer cells can restore both higher intercellular avidity and intercellular E-cadherin bond strength.
Technology trends in power-grid-induced noise (2002)

With technology scaling, the trend for high performance integrated circuits is towards higher power dissipation, higher operating frequency and lower power supply voltages. This causes a dramatic increase in power supply current being delivered through the on-chip power grid and is recognized in the International Technology Roadmap for Semiconductors as one of the difficult challenges. The design of appropriate power grids and the addition of decoupling capacitance has become crucially important in order to control power-grid-induced noise. In this paper, we show analytical relationships between noise and various technology parameters, and we show the resulting trends in noise based on current roadmap predictions.
Performance Analysis and Optimization of Asynchronous Circuits Produced by Martin Synthesis (1990)

We present a method for analyzing the timing performance of asynchronous circuits, in particular, those derived by program transformation from concurrent programs using the synthesis approach developed by Martin. The analysis method produces a performance metric (related to the time needed to perform an operation) in terms of the primitive gate delays of the circuit. Because the gate delays are functions of transistor sizes, the performance metric can be optimized with respect to these sizes. For a large class of asynchronous circuits -- including those produced by the Martin synthesis -- these techniques produce the global optimum of the performance metric. A CAD tool has been implemented to perform this optimization.
3D High-Spatial-Resolution Cerebral MR Venography at 3T: A Contrast-Dose-Reduction Study (2008)

At 3T, high-spatial-resolution cerebral MRV can be performed with contrast doses as low as 7.5 mL, without compromising image quality as compared with full-dose protocols, except in the smallest veins, and without compromise of acquisition speed or spatial resolution.
Rosacea: An update (2000)

Rosacea is a common inflammatory skin disease affecting the central face of adults. Its etiology is unknown. Early diagnosis and appropriate treatment, usually with topical or systemic antibiotics or both, minimizes symptoms and helps to prevent complications.
Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with Alzheimer&rsquo;s disease and related dementia living in long-term care facilities (2014)

A lighting intervention, tailored to increase daytime circadian stimulation, can be used to increase sleep quality and improve behavior in patients with ADRD. The present field study, while promising for application, should be replicated using a larger sample size and perhaps using longer treatment duration.
Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat (1996)

1. Rhythmic activity was induced with either serotonin (5-HT; 10-100 microM) or dopamine (0.1-1.0 mM), in the in vitro spinal cord preparation of neonatal rats, with one intact hindlimb attached. Patterns of activity were investigated with multiple EMG recordings and the spatiotemporal characteristics of 5-HT- and dopamine-induced activity compared. 2. Dopamine-induced rhythmic activity was slow (cycle duration: 2.2-70.1 s) and irregular, whereas rhythmic activity induced by 5-HT was fast (cycle duration: 1.3-5.1 s) and regular. 3. During 5-HT- and dopamine-induced rhythmic activity, the timing of muscular activity was similar for hip flexors and hip adductors, for semimembranosus (hip extensor), and for muscles controlling the ankle and the foot. 4. In contrast, notable differences in the phase in the pattern induced by 5-HT compared with that induced by dopamine were found in the biceps femoris, semitendinosus, and quadriceps muscles. Biceps femoris and semitendinosus (functional hip extensors and knee flexors) were always extensor-like during 5-HT-induced activity, whereas in dopamine, these muscles displayed flexor-like bursts and double bursts as well as extensor-like bursts. Lack of EMG activity in biceps femoris and semitendinosus was encountered also in dopamine. In rectus femoris, vastus lateralis, and vastus medialis (main function: knee extension), the activity was dominated by flexor-like bursts in 5-HT, whereas in dopamine the activity was shifted to a predominantly extensor-like pattern. 5. The relationship between flexor and extensor burst duration and cycle duration was more variable than described for locomotor activity in adult animals. 6. The relative timing of muscle activity was stable from P0 to P4. The most important difference between rats aged 0-1 days and rats aged 2-4 days was a delayed flexor-extensor transition in older animals. 7. The complex timing of hindlimb muscle activity was relatively unchanged after transecting all dorsal roots. 8. Finally, the relationship between flexor and extensor activity and ventral root discharges was determined. It was found that the L2 ventral root burst was in phase with simple flexors while the L5 burst coincide with the extensor phase. 9. We conclude, that 5-HT and dopamine can activate spinal central pattern generators (CPGs) that already at birth are able to produce distinct patterns of motor activity. Modulatory inputs thus seems to be able to reconfigure the CPGs to produce specific motor outputs.
A General Framework for Planning Landmark-Based Motions for Mobile Robots (2011)

In this paper, we present a novel generic approach for planning landmark-based motion. The method consists in selecting automatically the most relevant landmarks along a preplanned geometric path. It proposes a strategy to correct the trajectory and to smoothly switch among the landmarks of the environment. Experimental results highlight the relevance of the proposed formalism.
Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1 (2016)

Plasmodium falciparum virulence is associated with sequestration of infected erythrocytes. Microvascular binding mediated by PfEMP1 in complex with non-immune immunoglobulin M (IgM) is common among parasites that cause both severe childhood malaria and pregnancy-associated malaria. Here, we present cryo-molecular electron tomography structures of human IgM, PfEMP1 and their complex. Three-dimensional reconstructions of IgM reveal that it has a dome-like core, randomly oriented Fab2s units, and the overall shape of a turtle. PfEMP1 is a C- shaped molecule with a flexible N terminus followed by an arc-shaped backbone and a bulky C terminus that interacts with IgM. Our data demonstrate that the PfEMP1 binding pockets on IgM overlap with those of C1q, and the bulkiness of PfEMP1 limits the capacity of IgM to interact with PfEMP1. We suggest that P. falciparum exploits IgM to cluster PfEMP1 into an organized matrix to augment its affinity to host cell receptors.
Giga-π: a new compact parallel optical interconnect module (2002)

A compact (3.4 cc of volume) and low-cost parallel optical interconnect module, Giga-/spl pi/, with a throughput of 15 Gbit/s has been developed and successfully demonstrated. We use 1.3-/spl mu/m Fabry Perot laser diode arrays. We describe the features, packaging technology, and characteristics of the Giga-/spl Pi/ module.