gebhart/patrepeval huggingface dataset:
イネのクロロフィル突然変異の形質発現に関する研究(II) : 低温感受性xantha (1977)

The effect of growth temperature on the character manifestation in a xantha mutant of rice (CM-14), which was induced by n-nitroso-n-methylurea treatment, was investigated. The phenotype of xantha seedling was distinctly modified by temperature, having orange yellow leaves at 20℃ and light green leaves at 30℃. Therefore, the amounts of chlorophyll and carotenoid in the expanded third leaf was used as a indicator of character manifestation. The chlorophyll content was negligible at 20℃, whereas it was about 55% of wild type at 30℃. The carotenoid content was unchanged at any temperature, showing nearly the same content as the wild type. When the chlorophyll-deficient xantha seedlings grown in the light at 20℃ were transferred after the emergence of their third leaf to 25℃ or 30℃, the third leaf formed chlorophyll. This result is distinctly different from that obtained in the virescent mutants, in which the chlorophyll content was never changed when they transferred after the emergence of their third leaf from 20℃ to 30℃. On the other hand, when the green xantha grown at 30℃ were transferred to 20℃, chlorophyll content was unchanged. When etiolated xantha seedlings grown in the dark at 30℃ were exposed to incandescent light at 20℃ for various periods of time and then they illuminated at 30℃, all of the seedlings had a certain chlorophyll content, however, they reached this content quickly with increase in period of illumination at 20℃. It is thought from these results that the xantha is a mutant inhibited by low temperature from chlorophyll synthesis in the light.
THE INFLOW PREDICTION TO SEWAGE PROCESS USING CASE-BASED TECHNOLOGY AND ITS EFFECTIVENESS IN PROCESS OPERATION (2002)

In a combined sewer system, rainfall causes sudden increase of sewage water. Itsamount often reaches more than disposal capacity of a sewage plant, so the sewage water is poured into rivers and the sea without sewage purification. That causes a problem of an environmental pollution.The prediction of inflow into a sewage plant can provide an optimal operation plan for the sewage plant. So the prediction is useful for preventing from the emission of swage water with heavy pollution load in the beginning of rainfall.However, there are many difficulties to predict the sewage inflow using traditional modeling method because of its complex relationships between process and environment.To overcome the difficulties in this inflow prediction problem, we applied a case-based technology named Topological Case-Based Modeling (TCBM). TCBM has a capable of making a causal model easily from sampled data that include inherent characteristics of the object.In this paper, we introduce the results of inflow predictions by the model using TCBM in a swage plant and show the examples of effective applications of this model.
<title>Security enhancement of holograms with interference coatings</title> (2000)

Most people in developed nations are familiar with the hologram. It appears on VISA, Discover and MasterCard credit cards. It is doubtful however, that a great number of people could identify the respective images. The public tends to confirm the presence of such a security device rather than verifying the actual image. As noted by Steve McGrew, "It is very rare that security holograms are subjected to close inspection in actual use" .Thus,there is now the opportunity for the use of poor counterfeits or the substitution of commercial holograms for the genuine security hologram. In an effort to thwart counterfeiters, the hologram industry has resorted to more complex products with multiple images as the device is rotated. These enhanced images provide the observer with a high level of "flash" or aesthetic appeal. Unfortunately, this added complexity does not confer added security because this complex imagery is hard to communicate and recollection of such imagery is difficult, if not impossible, to remember2 Every type of first order diffraction structure, including conventional holograms and grating images, has a major shortcoming even if encapsulated in a rigid plastic. Under an overcast sky or other diffuse illumination all diffraction orders expand and overlap so that the diffraction colors are lost. Under such viewing conditions all such devices look silvery or pastel at best. An additional hurdle that security holograms must overcome, to be truly secure, is the ease of which holograms can be counterfeited. One step and two step optical copying, direct mechanical copying and even re-origination have been extensively discussed over the Internet.3 Ways to counteract all these methods have been discussed but the conclusion was that none of the countermeasures, taken alone, was an effective deterrent. It has been discovered that by combining diffraction effects with thin film interference effects, a security device can be made with new enhanced features that allow for ready identification by the average person while still preserving complex optical patterns. This new security device, using LightGateTM technology, also appears to overcome the cited disadvantages of holographic technology.
Learning user's preferences by analyzing Web-browsing behaviors (2000)

This paper describes a method for an information filtering agent to learn user's preferences. The proposed method observes user's reactions to the filtered documents and learns from them the profiles for the individual users. Reinforcement learning is used to adapt the most significant terms that best represent user's interests. In contrast to conventional relevance feedback methods which require explicit user feedbacks, our approach learns user preferences implicitly from direct observations of browsing behaviors during interaction. Field tests have been made which involved 10 users reading a total of 18,750 HTML documents during 45 days. The proposed method showed superior performance in personalized information filtering compared to the existing relevance feedback methods.
Bergamottin contribution to the grapefruit juice?felodipine interaction and disposition in humans (2004)

Bergamottin enhanced the oral bioavailability of felodipine and may cause a clinically relevant drug interaction in susceptible individuals. Grapefruit juice-drug interactions likely also involve other furanocoumarins, possibly acting in combination by additive or synergistic mechanisms. Bergamottin has systemic availability and is metabolized in vivo to 6',7'-dihydroxybergamottin.
Mass spectrometric peptide mapping analysis and structural characterization of dihydrodiol dehydrogenase isoenzymes. (1990)

The direct molecular weight determination and structural analysis of polypeptides and peptide mixtures have become amenable by the recent development of fast atom bombardment (FABMS) and 252Cf-plasma desorption (PDMS) mass spectrometry. FABMS and PDMS peptide mapping, i.e., the direct analysis of peptide mixtures resulting from proteolytic digestion, have been developed as powerful methods for the structural characterization of epoxide-metabolizing isoenzymes. The major advantage of this approach is provided by the selectivity of the endoproteolytic cleavage, combined with the specific and accurate molecular weight determination of complex digest mixtures containing peptides up to several thousands daltons in size. Furthermore, the mass spectrometric peptide mapping analysis can be combined with a range of protein-chemical modification reactions and with sequential degradation such as by carboxypeptidases. Both FABMS and PDMS peptide mapping have already been successfully applied to the structural differentiation of glutathione transferase and epoxide hydrolase isoenzymes in cases where references sequence data for at least one isoenzyme form was available. In the application described here, for a series of dihydrodiol dehydrogenase (DDH) isoenzymes with hitherto undetermined primary structures, a direct correlation between the structural differentiation from peptide mapping data and differences in their substrate specificities could be demonstrated. The mass spectrometric peptide mapping analysis of isoenzymes proved to be an efficient basis for the elucidation of the structure of one major DDH isoenzyme form; partial sequence data for this protein are reported.
72nd Congress of the Italian Society of Pediatrics (2017)

Study on 88 adolescents with severe obesity (BMI >99°pc WHO), median age 12 ± 2 yrs, F 45%, of which 57 treated with Therapeutic Education and 31 with Dietotherapy. At T0: BMI 30.2 ± 5, BMI z score 2.98 ± 0,4. Grade of excess weight after 2.5 ± 1.3 years in the two groups. [Tanas R Congresso Nazionale Società Italiana di Medicina dell’Adolescenza, Palermo 2012]
CCDC 971041: Experimental Crystal Structure Determination (2013)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Evaluating Voice Traffic in a Differentiated Services Environment (2001)

This paper evaluates the performance achieved by voice traffic when using Expedited Forwarding (EF) and Assured Forwarding (AF) schemes in a Differentiated Services (DS) environment. The mutual inuence of the two schemes is evaluated: (i) when a controlled amount of voice bursts are allowed into a DS domain; (ii) in the presence of an increasing number of voice flows handled by EF; and (iii) for different packet sizes of the best-effort traffic. Results show that allowing controlled EF traffic bursts into a DS domain does not significantly increase the delay and jitter of the AF traffic if idle periods from EF traffic do not become scarce. Results also show that different packet sizes of the best-effort traffic exert a stronger influence on the delay of AF packets than on the delay of EF packets
Magnetic Nanoparticle-Based Mechanical Stimulation for Restoration of Mechano-Sensitive Ion Channel Equilibrium in Neural Networks (2017)

Techniques offering remote control of neural activity with high spatiotemporal resolution and specificity are invaluable for deciphering the physiological roles of different classes of neurons in brain development and disease. Here, we first confirm that microfabricated substrates with enhanced magnetic field gradients allow for wireless stimulation of neural circuits dosed with magnetic nanoparticles using calcium indicator dyes. We also investigate the mechanism of mechano-transduction in this system and identify that N-type mechano-sensitive calcium ion channels play a key role in signal generation in response to magnetic force. We next applied this method for chronic stimulation of a fragile X syndrome (FXS) neural network model and found that magnetic force-based stimulation modulated the expression of mechano-sensitive ion channels which are out of equilibrium in a number of neurological diseases including FXS. This technique can serve as a tool for acute and chronic modulation of endogenous ion channel expression in neural circuits in a spatially localized manner to investigate a number of disease processes in the future.
Differential Effects of the Antianginal Drug Nicorandil on Canine Arteries and Veins (1990)

Nicorandil, a potent coronary vasorelaxant used in the treatment of angina, has differential effects on arteries and veins in vivo. To explain this phenomenon, experiments were designed to characterize the relaxant and inhibitory actions of this compound on canine isolated arteries and veins. Paired rings of canine coronary, femoral, and saphenous arteries and saphenous veins were suspended at optimal length for isometric tension recording in organ chambers containing physiologic salt solution at 37 degrees C and gassed with 95% O2-5% CO2. In certain experiments, one ring of each pair was denuded of the endothelium. Removal of the endothelium did not affect nicorandil-induced relaxations of contracted blood vessels. Nicorandil exerted a differential relaxant effect on arteries and veins contracted with KCl (order of potency: saphenous vein greater than coronary artery greater than femoral artery). No difference in sensitivity to nicorandil was observed in arteries and veins contracted with prostaglandin F2 alpha. Contractions of saphenous arteries and veins to norepinephrine (NE) were equally sensitive to the inhibitory action of nicorandil. However, contractions of saphenous veins induced by sympathetic nerve stimulation were more sensitive to nicorandil than were contractions of saphenous arteries. Furthermore, nicorandil did not affect contractions to phenylephrine in saphenous veins, although contractions to B-HT 920 were virtually abolished by the compound. Saphenous veins contracted with St 587 were more sensitive to the relaxant action of nicorandil than when contracted with phenylephrine. These results suggest that nicorandil inhibits preferentially contractions of canine arteries and veins mediated by alpha 2- rather than alpha 1-adrenoceptors.(ABSTRACT TRUNCATED AT 250 WORDS)
STATUS OF THE MEVVA HIGH CURRENT METAL ION SOURCE (1987)

1 he MEVVA (Metal Vapor Vacuum Arc) ion source that has been developed at LBL was reported on lor the first time at the 1985 Particle Accelerator Conference [1].Ihis source can produce hundreds ol milliamperes of beam current of metal species from lithium up to uranium.In the period since then we have developed the source further, and this work is summarized here.We have now run the source with over 30 different beam species, and with an extraction voltage up to 110 kv.We have made and operated a miniature source, the MicroMEVVA.A multi -cathode version, in which one can switch rapidly between cathodes of different materials, has recently been constructed and tested.Applications of the source include: as a synchrotron ion source, as an ion source for heavy ion fusion, and for metallurgical ion implantation; we have done some preliminary work in these directions.
A Postural Model of Balance-Correcting Movement Strategies (1992)

The patterns of joint torques and movement strategies underlying human balance corrections were examined using a postural model. Two types of support-surface perturbation, dorsiflexion rotation (ROT) and rearward translation (TRANS), were employed. These two perturbations were adjusted to produce similar profiles of ankle dorsiflexion in order to obtain information on the role of lower leg proprioceptive inputs on triggering balance corrections. In addition, the dependence of balance control on head angular and linear accelerations was investigated by comparing the responses of normal and vestibularly deficient subjects under eyes-closed and eyes-open conditions. Differences in ROT and TRANS movement strategies were examined in three ways First, the amplitude and polarity of active joint torques were analysed. These were obtained by altering joint torques applied to a postural model until movements of the model accurately duplicated those of measured responses. Second, the pattern of body-segment angular movements depicted by stick figures moving in response to the computed joint torques was investigated. Third, the peak amplitude and patterns of crosscorrelations between joint torques were measured. Active ankle, knee, and hip joint torques computed for normal subjects rotated the body forward for ROT. In the case of TRANS, computed active torques in normals were of opposite polarity to those of ROT and reversed the forward motion of the body. Subjects with vestibular deficits had lower amplitude torques for ROT and failed to counter the platform rotation. Hip torques for TRANS in vestibular deficient subjects were of opposite polarity to those of normal subjects and resulted in excessive forward trunk rotation. Normally, neck torques acted to stabilize the head in space when trunk angular velocity peaked. Vestibular deficient subjects displayed head movements in response to ROT similar to those generated when neck torques were absent. For TRANS, these same subjects exhibited overcompensatory neck torques. Stick figures of normal responses indicated a stiffening of the body into a leg and a trunk-head link for ROT and a flexible multilink motion for TRANS. Likewise, normal response strategies, defined by using crosscorrelations of joint torques, differed for ROT and TRANS. All joint torque crosscorrelations were significant for TRANS. Neck torques led those of all other joint torques by 40 ms or more, and hip joint led ankle torques by 30 ms. Joint torque correlations for ROT were organised around hip and ankle torques without a major correlation to neck torques. Fundamental changes in all torque crosscorrelations occurred for vestibularly deficient subjects under both eyes-open and eyes-closed conditions.(ABSTRACT TRUNCATED AT 400 WORDS)
Minimum alveolar concentration: ongoing relevance and clinical utility (2013)

Since its introduction in 1965, minimum alveolar concentration (MAC) has served as the standard measure of potency for volatile anaesthetic agents. It is defined as the minimum alveolar concentration of inhaled anaesthetic at which 50% of people do not move in response to a noxious stimulus. Within the last 20 years, it has been discovered that volatile anaesthetics inhibit mobility largely through action on the spinal cord, whereas the amnesic and hypnotic effects are mediated by the brain. Studies suggest that the concentration of volatile anaesthetic needed to prevent explicit memory from developing, and to produce unconsciousness, is usually substantially lower than the concentration required to prevent movement in response to surgery. This review highlights the contributions and limitations of MAC and its derivatives as metrics of anaesthetic potency with respect to particular behavioural outcomes. Recent evidence is presented suggesting that a protocol that alerts anaesthetists whenever MAC falls to < 0.5 or 0.7 has the potential to decrease intra-operative awareness with explicit recall, possibly to a similar extent as does a protocol based on processed electroencephalography-driven alerting.
Abstract B104: Tid1 as a novel target for HSP-directed therapy in NSCLC. (2011)

Abstract Molecular chaperones, commonly known as heat shock proteins (HSPs), are essential for mammalian cells to maintain homeostasis. HSPs may interact with diverse co-chaperones and induce an ATPase-coupled structural change in client proteins and regulate critical signaling networks. More than 200 client proteins have been identified which may serve as important therapeutic targets in human diseases. The human tumorous imaginal disc 1 (Tid1) protein, a member of the DnaJ domain protein family, is a tumor suppressor and is known to promote ubiquitin-mediated degradation of oncogenic kinases. The Tid1 is a heat shock protein and function as molecular chaperone. In this work, we investigated the role of Tid1 in the tumorigenesis of non-small-cell lung cancer (NSCLC). The expression of two alternatively spliced isoforms of Tid1 (Tid1L and Tid1S) as well as EGFR was examined with RT-PCR and immunohistochemistry (IHC) in tumors from NSCLC patients. The expression of Tid1 was reduced in the majority of NSCLCs and an inverse correlation was observed for the expression of Tid1 and EGFR. Furthermore, we demonstrated that Tid1L, EGFR, HSP70, and HSP90 interacted with each other, and this interaction is dependent on functional DnaJ domain of the Tid1L. Overexpression of the Tid1L in lung cancer cells in vitro inhibited cell proliferation, anchorage-independent growth, and induced apoptosis. We further showed that overexpression of the Tid1L in lung cancer cells attenuated EGFR signaling activity and inhibited the activation of AKT, ERK and STAT3. In contrast, knockdown of Tid1 in EGFR-transfected lung cancer cells markedly increased the stability of EGFR. Taken together, our results support that Tid1L may play a critical role in regulating EGFR signaling in NSCLC; raising the possibility that Tid1 may be a novel target for HSP directed therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B104.
Simple theory of current fluctuations and noise in bridge-mediated nano-junctions (2008)

We develop a simplified, model theory of noise caused by highly damped oscillating conformational fluctuations of a chain molecule mediating a nano-junction. Considering the most 'primitive' approximation of direct tunneling of electrons and barrier coupling with collective coordinates that describe internal conformations of the chain molecule, we derive approximate analytical formulas for the temporary current correlation function, noise power, and Fano factor. We analyze the role of different cumulative parameters of the model that affect the noise, as well as the effect of the temperature and of the number of groups in the chain. We present this analysis in expectation of experiments on this type of noise and in an attempt to trigger such experiments.
ChemInform Abstract: SYNTHESIS AND ABSOLUTE CONFIGURATION OF (R)‐ AND (S)‐ETHYL 3‐(4‐OXOCYCLOHEX‐2‐ENYL)PROPIONATE (1985)

Abstract Das nach Diels‐Alder gut zugängliche Carbonsäure‐Gemisch (I) wird über eine Iodlactonisierung unter Bildung von (II) und (III) aufgetrennt.
Binary Systems Formed by Alkali Bromides with Barium or Strontium Bromide (1970)

By DTA and visual methods the phase diagrams of the ten binary systems formed by lithium, sodium, potassium, rubidium and cesium bromide with barium or strontium bromide have been drawn. Moreover, the fusion thermal effects regarding the eutectics and the congruent compounds singled out in the systems have been evaluated. The general thermodynamic behaviour of these systems is discussed in comparison with the ideal one.
Energy Efficient with Network Coding Multipath Routing Algorithm in Wireless Sensor Networks (2014)

. Through an analytical study, we provide guidance on how to choose parameters in our scheme and demonstrate that the scheme is efficient in both multipath and energy consumption. We also present an algorithm for deciding the network coding scheme for a node to further reduce energy consumption by minimizing redundant packet transmissions. Simulation results show that, with the proposed energy efficient with network coding in WSN multipath routing protocol (ENM-WSN), energy consumption, packet delivery ratio, and network lifetime can be improved in most of cases. It is an available approach to multipath routing decision.
A camera based closed loop control system for keyhole welding processes: Algorithm comparison (2010)

Real time monitoring of laser welding has a more and more importance in several manufacturing processes ranging from automobile production to precision mechanics. Despite the huge improvement in welding technology, sophisticated image based closed loop control systems have not been integrated in commercially available equipments yet. Due to the high dynamics of laser beam welding (LBW) processes, robust closed loop control systems require fast real time image processing with frame rates in the multi kilo Hertz range. In the last few years, some new high speed Cellular Neural Network (CNN) based algorithms for the full penetration hole detection in keyhole welding processes have been introduced. In particular, they can be distinguished in two categories: Orientation dependent and orientation independent algorithms. The former can be used only for the welding of straight lines, while the latter has been implemented for the control of curved weld seams. Both algorithms have been used to build up a real time closed loop control system for LBW processes. An algorithm comparison by the description of some experimental results is addressed in this paper.