gebhart/patrepeval huggingface dataset:
Prospects for Early Detection of Alzheimers Disease from Serial MR Images in Transgenic Mouse Models (2009)

The existing literature on the magnetic resonance imaging of murine models of Alzheimer's disease is reviewed. Particular attention is paid to the possibilities for the early detection of the disease. To this effect, not only are relaxometric and volumetric approaches discussed, but also mathematical models for plaque distribution and aggregation. Image analysis plays a prominent role in this line of research, as stochastic image models and texture analysis have shown some success in the classification of subjects affected by Alzheimer's disease. It is concluded that relaxometric approaches seem to be a promising candidate for the task at hand, especially when combined with sophisticated image analysis, and when data from more than one time-point is available. There have been few longitudinal studies of mice models so far, so this direction of research warrants future efforts.
pH and Haemoglobin Oxygen Affinity in Blood from the Antarctic Cod Dissostichus Mawsoni (1977)

ABSTRACT Blood pH in the antarctic cod (Dissostichus mawsoni) and in two Trematomus species, occurring at –1·9°C, is extremely high ( ∼ 8·2 to 8·3). This supports and extends Rahn’s (1966) model for the temperature-pH relationship in cold-blooded vertebrates. The blood of D. mawsoni shows a low oxygen affinity (P50 ≃ 14·5 mmHg at pH 8·16 and – 1·9°C). Despite normal in vitro temperature and pH sensitivities, blood P50 increases only slightly when five fish are temperature-stressed ( + 4 ·0 °C), or become acidotic as a result of agitational stress (blood pH 7 ·71 ), primarily as a result of compensatory decreases in blood ATP levels. Oxygen-binding properties of ‘stripped’ (cofactor-firee) solutions of D. maw-soni haemoglobin were measured in attempts to elucidate the molecular mechanisms involved in the function of the pigment.
Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate (2017)

The CSF actively penetrates within the brain parenchyma in the gyrencephalic brain, as described for the glymphatic system in rodent. This parenchymal CSF circulation is severely impaired by SAH.
Rheumatologic Evaluation of Adjuvant Letrozole in Post-Menopausal Breast Cancer Patients Discontinuing Anastrozole Due to Grade 2-3 Arthralgia – Myalgia. (2009)

Abstract Background:Non-steroidal aromatase inhibitors (AIs) are standard of care in the adjuvant treatment of postmenopausal women with hormone receptor positive (HR+) early stage breast cancer. Side effects such as arthralgia and/or myalgia (A/M) occur in 20 -35% of women on AI therapy with onset as early as 1-2 months from AI initiation. As many as 20% of patients may discontinue therapy due to A/M. Switching to another AI could improve the A/M and allow patients to remain on AI therapy. This study evaluated if patients (pts) who discontinued anastrozole (Ana) due to grade 2-3 A/M would be able to continue AI therapy if switched to Let. We measured whether switching to Let resulted in a lower proportion of grade &amp;gt;2 A/M symptoms and less discontinuation among women who previously discontinued Ana therapy due to A/M.Methods: Pts were eligible for treatment with Let (2.5mg/day for 6 months) if they were postmenopausal, HR+, had early stage breast cancer including LCIS and DCIS, and experienced grade 2-3 A/M on Ana resulting in discontinuation. Pts taking analgesics for any reason were excluded. A/M symptoms and self reported quality of life (QoL) outcomes were assessed by Basic Pain Inventory (BPI), Visual Analog Scale (VAS) and Health Assessment Questionnaires (HAQ) at baseline, during Let therapy and upon study completion. Pts tolerating Let therapy at 6 months had the option of continuing Let for their prescribed course of 5 years.Results: The study enrolled 261 pts of which 2 pts were ineligible. The median age of pts was 61, and 235 (90%) were Caucasian, 14 (5.4%) were Black, 3 (1.2 %) were Asian and 9 (3.4%) were other. At baseline, 107 (41.0%) and 70 (26.8%) had grade 2 or higher A/M respectively. At study completion, fewer patients suffered from grade ≥ 2 A/M, 61 (23.6%) and 46 (17.8%) respectively. Changes in QOL assessments showed a statistically significant improvement (p &amp;lt;0.05) according to the BPI composite score, VAS scale and disability index of the HAQ at -0.5, -6.4 and -0.1 respectively. 228 (87.4 %) pts remained on Let therapy until study completion (6 months). Only 25 (9.6%) of the 261 pts enrolled discontinued due to A/M and another 8 (3.1%) discontinued for other reasons. The mean time to AI discontinuation due to A/M was 157 days and the median duration of study drug was 169 days. Baseline A/M grade, age, BMI, prior use of pain medications or baseline vitamin D results were not significantly associated with Let discontinuation.Conclusion:These results suggest that pts who are intolerant of and have discontinued Ana due to A/M may better tolerate AI therapy and avoid discontinuation when switched to Let. Less A/M and QoL function were maintained upon switching to Let with, 228 (87.4 %) of women in this study remaining on therapy with Let despite previous discontinuation of Ana due to A/M. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 805.
Numerical Modelling and Mitigation Technique of Welding Distortion for Fillet Welding of Aluminum Plate (2016)

Numerical Modelling and Mitigation Technique of Welding Distortion for Fillet Welding of Aluminum Plate M. Tsunori, M. Mouri, S. Saso, H. Kusumoto Abstract. In marine and offshore industries, aluminium welding processes are often used especially for floating LNG (Liquefied Natural Gas) production, storage and LNG fuelled vessels. Welding distortions of aluminium plates are known to […]
Correlation between the hydrophobic nature of monosaccharides and cholates, and their hydrophobic indices (1988)

Hydrophobic and hydrophilic surface areas, which are the surface areas occupied by CH and CH2 groups and by OH, COO– and ether oxygen groups, respectively, are calculated for monosaccharides and cholates using the computer program developed by Hermann. Hydrophobic indices, defined by the surface-area ratio of the hydrophobic to hydrophilic groups, correlate well with the partition coefficients of the polystyrene–water system for monosaccharides and with values of the critical micelle concentration for cholates. These facts indicate that the concept of hydrophobic index is important in considering hydrophobic interactions of flat molecules in aqueous solutions.
2 kW Pulse Power from Internal Wavelength Stabilized Diode Laser Bar for LiDAR Applications (2022)

We present a bipolar-cascade distributed-Bragg-reflector laser bar with an intended wavelength of 905 nm emitting 8 ns long pulses with 2 kW peak power at a current slightly above 1 kA into the third vertical mode. The spectral width of the pulses is 0.3 nm.
S5 IMPLANT ARTHROPLASTY OF THE HAND IN JAPAN (2006)

Development of newer finger implant in Japan started with hinged Ceramic implant in early 1980’ and was abandoned its use in early stage (Doi 1984 and Minami 1988). Although silicone finger implant has been most popular, breakage of the implant, particle induced inflammation and implant subsidence continued to be the problems of the silicone implant. In turning to new century, there was another enthusiasm of developing new finger implant in Japan. Surface replacement was chosen for the PIP joints, however, most of design for the MP joint had constrained mechanism, including ball and socket joint with stem allows piston motion and semi-hinged joint with much freedom. Currently available finger implants in Japan will be discussed briefly. The author developed cement-less surface finger implants (Self Locking Finger Joint, SLFJ) for the MP (including thumb) and PIP. Characteristics of the implant include,(1) the joints anchor(stem) has tapered screw with two long legs which spread intramedullary allows fixation without cement and thus change the position during the operation for optimum collateral tension, (2) joint design that preserve collateral ligament and surface contour, (3) simultaneous replacements of both MP and PIP are possible. Over 500 joins in 200 patients have been operated during last seven years. Of 50 cases operated by author with minimum of 4 years follow up, 34 cases were available for evaluation. There were 98 joints: 72 MP, 12 PIP and 14 MP of the thumbs. Average follow up was 5 years and 5 months (4 years ~ 6 years and 6 months). Fixation of the joints anchor were stable, only three joints showed marked loosening. Breakage of the joint anchors was found in 7 MP and 2 PIP; 5 out of 9 breakage of the legs were occurred during the operation. In x-ray evaluation, about half of the joint anchors were found securely fixed to the bone within 2 years. Dislocations of the joints were found in 4 MP joints in 3 cases (3 were early dislocation and were found to be technical failure and one late dislocation) and 2 PIP joints (one early and one late dislocation). Five MP implants were removed because of progressive flexion contracture and 3 MP and 2 PIP were re-operated. Range of motion of ext/flex averaged −25/70 in MP and −20/65 in PIP.
Large bowel transit times using radiopaque markers in normal cats (1995)

Seven normal, young adult, female cats each had its colon evacuated with warm-water enemas (at 24 hours, 12 hours, and one hour) before oral administration of a gelatin capsule containing 20 radiopaque markers to determine normal colonic transit times. Abdominal radiographs were taken twice daily until all markers were expelled. There were no significant differences between animals or trials (p = 0.05 or less). Markers accumulated in the first section of large bowel within eight hours. Evacuation from the colon took another 40 hours. Cecum (right side midline), left side midline, and rectum were defined radiographically. This study establishes large bowel transit times in normal cats and provides the basis for similar evaluation in constipated cats.
Chinese herbal medicine TangBi Formula treatment of patients with type 2 diabetic distal symmetric polyneuropathy disease: study protocol for a randomized controlled trial (2017)

ClinicalTrials.gov, NCT03010241 . Registered on 2 January 2017.
Wide-field broadband extreme ultraviolet transmission ptychography using a high-harmonic source (2016)

High-harmonic generation (HHG) provides a laboratory-scale source of coherent radiation ideally suited to lensless coherent diffractive imaging (CDI) in the EUV and x-ray spectral region. Here we demonstrate transmission extreme ultraviolet (EUV) ptychography, a scanning variant of CDI, using radiation at a wavelength around 29 nm from an HHG source. Image resolution is diffraction-limited at 54 nm and fields of view up to ∼100 μm are demonstrated. These results demonstrate the potential for wide-field, high-resolution, laboratory-scale EUV imaging using HHG-based sources with potential application in biological imaging or EUV lithography pellicle inspection.
C2, C5, and C4 Azole N-Oxide Direct Arylation Including Room-Temperature Reactions (2008)

The N-oxide group imparts a dramatic increase in reactivity at all positions of the azole ring of thiazoles and imidazoles and changes the weak bias for C5 > C2 arylation to a reliable C2 > C5 > C4 reactivity profile. Use of this cross-coupling strategy enables high yielding and room-temperature C2 arylations, mild reactions at C5, and the first examples of C4 arylationproviding a unique opportunity for exhaustive functionalization of the azole core with complete control of regioselectivity. A correlation of reactivity with the relative contributions of each carbon atom to the HOMO is observed and discussed.
Determination of the pipe stemming load (1979)

A mechanical model for the emplacement pipe system is developed. The model is then employed to determine the force applied to the surface collar of the emplacement pipe, the pipe-stemming load, and the stress along the emplacement pipe as a function of stemming height. These results are presented as integrals and a method for their numerical integration is given.
Left Ventricular Thrombus Identification A Scintigraphic and Echocardiographic Correlation (1993)

A prominent and protruding left ventricular filling defect was noted on a routine radionuclide ventriculogram in a patient with congestive heart failure. An echocardiogram further documented the existence of a septal thrombus, which was suspected by radionuclide ventriculogram.
Temporal profile of T2-Weighted MRI Distinguishes between Pannecrosis and Selective Neuronal Death after Transient Focal Cerebral Ischemia in the Rat (2005)

Transient middle cerebral artery occlusion (MCAO) by an intraluminal thread leads to primarily subcortical infarctions with little sensorimotor impairment in the Wistar rat strain. We investigated the course of infarct development in this lesion type for 10 weeks using magnetic resonance imaging (MRI) along with histological characterization. MCAO was induced in male Wistar rats (260 to 300 g) for 60 mins. Animals received follow-up T1- and T2-weighted MRI from day 1 until week 10. Separate groups of animals were analyzed histologically after 2, 6, and 10 weeks. Histology included immunohistochemistry for neuronal and astrocytic markers as well as hematoxylin eosin and luxol fast blue-cresyl violet staining. In contrast to lesions involving the cortex, exclusively subcortical infarctions were characterized by a complete resolution of initially increased T1 and T2 relaxation times by 10 weeks. Between 2 and 10 weeks, neuronal death and gliosis as well as a dense inflammatory infiltrate were evident in these lesions, without damage to fiber tracts or development of cystic cavities. Exclusively subcortical lesions in Wistar rats are characterized by normalization of T1 and T2 relaxation times, which might, however, not be mistaken for tissue recovery. Despite this MRI normalization, selective neuronal death and gliosis develop. Although MRI at individual time points might therefore be ambiguous, the temporal profile of relaxation time changes over the chronic time period allows discrimination of the lesion development into selective neuronal death or pannecrosis.
Young Bone Marrow Sca-1 Cells Rejuvenate the Aged Heart by Promoting Epithelial-to-Mesenchymal Transition: Erratum (2023)

[This corrects the article DOI: 10.7150/thno.22788.].
Realisierung eines Konzepts zur Diagnose Ethernet-basierter Echtzeitkommunikationssysteme (2012)

Diese Arbeit beschaftigt sich mit dem Thema der Diagnose von Echtzeitkommunikationssystemen auf Basis von Industrial Ethernet. Durch die Visualisierung soll ein Uberblick uber das Kommunikationssystem vermittelt und eine effektive Diagnose ermoglicht werden. Um den Nutzer zu unterstutzen, sollen auf Basis von Anamoliedetektion Fehlermeldungen analysiert und die moglichen Fehlerquellen lokalisiert werden. Zusatzlich zur Vorstellung dieses Konzeptes wird der aktuelle Implementierungsstand erlautert. Im ersten Schritt wurden Methoden der Datenextraktion und der Visualisierung implementiert.
Niedermolekulare Verbindungen aus Spinnen als chemische Sensoren (2011)

Abstract Spinnen sind für viele Ökosysteme wichtig, und als Hauptfeinde von Insekten verfügen sie über eine Fülle von niedermolekularen Naturstoffen mit faszinierenden biologischen Wirkungen. Die Isolierung und die biologische Charakterisierung dieser Verbindungen sind wohlbekannt, aber erst kürzlich wurden sie als Leitstrukturen für die Entwicklung, Synthese und biologische Untersuchung synthetischer Analoga verwendet. Weit weniger erforscht sind hingegen Verbindungen, die der Kommunikation von Spinnen dienen. Vor kurzem wurden jedoch auf dem Gebiet der Pheromone und Allomone aus Spinnen neue Erkenntnisse erhalten, die wir hier zusammenfassen und mit früheren Ergebnissen in Zusammenhang bringen. Abschließend geben wir einen Ausblick auf künftige Untersuchungen an dieser Art von Verbindungen.
The role of AiiA, a quorum-quenching enzyme from Bacillus thuringiensis, on the rhizosphere competence. (2008)

Bacteria sense their population density and coordinate the expression of target genes, including virulence factors in Gram-negative bacteria, by the N-acylhomoserine lactones (AHLs)-dependent quorum-sensing (QS) mechanism. In contrast, several soil bacteria are able to interfere with QS by enzymatic degradation of AHLs, referred to as quorum quenching. A potent AHL-degrading enzyme, AiiA, of Bacillus thuringiensis has been reported to effectively attenuate the virulence of bacteria by quorum quenching. However, little is known about the role of AiiA in B. thuringiensis itself. In the present study, an aiiA-defective mutant was generated to investigate the role of AiiA in rhizosphere competence in the root system of pepper. The aiiA mutant showed no detectable AHL-degrading activity and was less effective for suppression of soft-rot symptom caused by Erwinia carotovora on the potato slice. On the pepper root, the survival rate of the aiiA mutant significantly decreased over time compared with that of wild type. Interestingly, viable cell count analysis revealed that the bacterial number and composition of E. carotovora were not different between treatments of wild type and the aiiA mutant, although root application of the aiiA mutant in pepper failed to protect the plant from root rot. These results provide evidence that AiiA can play an important role in rhizosphere competentce of B. thuringiensis and bacterial quorum quenching to Gram-negative bacteria without changing bacterial number or composition.
Results of a Comparative Study of a Reconstruction Procedure for Producing Improved Estimates of Radioactivity Distributions in Time-of-Flight Emission Tomography (1984)

Several reconstruction algorithms for estimating distributions of radioactivity in an emission-tomography system having time-of-flight measurements have previously been identified. We present here a comparative study of various images reconstructed from data acquired with an emission-tomography system having time-of-flight data. Preliminary results indicate that a new recursive algorithm provides substantial improvements in image quality.
Effect of cilofungin (LY121019), a fungal cell wall synthesis inhibitor, on interactions of Candida albicans with human neutrophils (1989)

The effects of cilofungin, a lipopeptide antifungal agent active against several species of Candida, on human neutrophil candidacidal activity were investigated. While no increase or decrease in neutrophil killing of blastospores was observed when cilofungin was simultaneously incubated with neutrophils and yeasts, preincubation of yeasts with serum containing cilofungin resulted in approximately 90% decrease in killing of five of six strains. Attachment/phagocytosis of these strains was unchanged from controls. We conclude that cilofungin interferes with opsonization of most strains of C. albicans, resulting in a marked decrease in neutrophil candidacidal activity, a phenomenon which may be of significance in vivo in certain tissues where access to antibodies and/or complement is limited.
Detection and Isolation of Small Faults in Lithium-Ion Batteries via the\n Asymptotic Local Approach (2021)

This contribution presents a diagnosis scheme for batteries to detect and\nisolate internal faults in the form of small parameter changes. This scheme is\nbased on an electrochemical reduced-order model of the battery, which allows\nthe inclusion of physically meaningful faults that might affect the battery\nperformance. The sensitivity properties of the model are analyzed. The model is\nthen used to compute residuals based on an unscented Kalman filter. Primary\nresiduals and a limiting covariance matrix are obtained thanks to the local\napproach, allowing for fault detection and isolation by chi-squared statistical\ntests. Results show that faults resulting in limited 0.15% capacity and 0.004%\npower fade can be effectively detected by the local approach. The algorithm is\nalso able to correctly isolate faults related with sensitive parameters,\nwhereas parameters with low sensitivity or linearly correlated are more\ndifficult to precise.\n
Robust state estimation of electricity‐gas‐heat integrated energy system based on the bilinear transformations (2020)

Abstract A comprehensive energy system state estimation is of great significance to promote efficient, stable and reliable operation of the system. Based on coupling characteristics of electricity‐gas‐heat multi‐energy flow and bilinear transformation method, this paper proposes a robust state estimation method suitable for integrated energy systems. First, the state estimation models of electricity, gas and heat energy subsystems and coupling components are constructed. Then, by introducing pseudo state variables and intermediate variables, the nonlinear state estimation process is divided into four stages. Among them, the first and third stages are solved by WLAV method and WLS method respectively, and the second and fourth stages are simple nonlinear transformation processes. Finally, the robust state estimation method is verified on a 40‐node simulation example. The bilinear robust state estimation method proposed not only solves the difficulty of selecting initial values of heterogeneous networks and the problem of non‐convergence of algorithms, but also can search and identify various types of bad data, and has high computational efficiency and good robustness.
Evaluation des risques liés à la production d'amines biogènes par des staphylocoques à coagulase négative isolés de fromages et salaisons (2008)

National audience
Influence on the accuracy of clamp-on ultrasonic flowmeters due to the recombination of multiple propagation paths (2017)

The following topics are dealt with: biomedical ultrasonics; medical image processing; ultrasonic imaging; biological tissues; ultrasonic transducers; biomechanics; blood vessels; biomedical transducers; diseases; and cancer.
Twinning in Laves Phases by Synchroshear: Atomic Mechanisms and Compositional Control. Final report, May 15, 1997 to August 31, 2001 (2003)

Compression tests between 4.2 and 1273 K, compositional variation and conventional transmission electron microscopy were used to investigate the deformation and twinning behavior of C15 HfV2+Nb - based Laves phase alloys. We chose two phase C15/bcc alloys to improve the ambient temperature ductility which has not been found in the single phase Laves intermetallic compound. Transmission electron microscopy revealed that substantial mechanical twinning takes place in the CI5 Laves phase matrix at room temperature and 77 K. A deep minimum in the flow stress, with a drop of nearly 500 MPa, appears at around 77 K in the C15/bcc two-phase alloy with C15 matrix. Since no such anomaly is seen in the bcc phase, we believe that the cause of this can be attributed to mechanical twinning in the CI5 Laves phase. Twin bands observed in the CI5 matrix of deformed samples at both 298 K and 77 K can be classified into three categories by their thicknesses; coarse twin bands about 10nm to several hundreds nm thick, fine twin bands around 3 to 10 nm thick, and ultra fine twin bands with average thickness of 1.5 nm. A high density of ultra-fine twin bands is the characteristic feature of twinning in the C15 matrix. They belong to the <112>(111) twinning system and commonly intersect with each other.