gebhart/patrepeval huggingface dataset:
Doppler recordings of fetal movement: II. Comparison with maternal perception. (1990)

Twenty-seven women were studied to assess the relationship between maternally perceived fetal movement and that recorded by a Doppler device. Eighty-eight percent (433 of 492) of maternally perceived movements were detected by Doppler, but only 16% of movements detected by Doppler were maternally perceived (433 of 2196). When complex movements were classified by duration, those movements lasting between 20-60 seconds were most likely (correlation greater than 0.9) to be perceived by the mother. This Doppler method has the potential to replace maternal event marking and other techniques in the recording of fetal movement.
Characterization of a highly structured domain in Tbp2 from Neisseria meningitidis involved in binding to human transferrin (1994)

The binding of iron-loaded human transferrin at the surface of Neisseria meningitidis is mediated by two polypeptides, Tbp1 and Tbp2. Predicted Tbp amino acid sequences from N. meningitidis strains are highly divergent. This variability is particularly pronounced throughout the Tbp2 polypeptide. In this study, a highly structured and extremely stable Tbp2 domain of about 270 to 290 amino acids which is involved in the binding to transferrin and whose position is well conserved has been characterized. The conservation of such a remarkable structure in a very divergent protein domain (there is only 43% amino acid identity within this region) suggests that is plays an essential biological role and raises a number of questions regarding tbp2 evolution.
Polyangiitis overlap syndrome: a rare clinical entity (2023)

Polyangiitis overlap syndrome is a rare clinical entity comprising patients with overlapping features of more than one vasculitis, usually eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis (GPA). Few cases of polyangiitis overlap syndrome have been described in the literature, mostly associated with c-ANCA, anti-proteinase (PR)-3 positivity, a protean clinical picture characterized by vasculitis, eosinophilia and eosinophilic infiltrates in tissues and a favorable response to steroids and immunosuppressant treatments. Herein, we present a case of a 66-year-old woman with nasal obstruction, external nose deformity, sensorineural hearing loss, peripheral blood eosinophilia, high titer anti-PR3 antibodies and lung involvement. Nasal septum biopsies showed inflammatory infiltrate with eosinophilic component; histopathology of the lung demonstrated necrotizing granulomas associated with inflammatory infiltrate composed of numerous neutrophils and some eosinophils. The patient was diagnosed with polyangiitis overlap syndrome and successfully treated with cyclophosphamide. Recognizing this entity is fundamental given the distinct clinical phenotype and outcomes to therapy in the complex scenario of ANCA-associated vasculitides.
Microwave thermotherapy in benign prostatic hypertrophy (1993)

The response to transurethral microwave thermotherapy (TUMT) is thermal-dose-dependent. Over 70% of patients can be relieved of their symptoms using conventional TUMT (intraprostatic temperatures between 46 and 60°C). More severe degrees of bladder outflow obstruction will require high temperature treatment (<60°C) using the same device but with the treatment parameters of thermo-ablation to create a cavity within the prostate. In either protocol, treatment is delivered during a single 1 h session, on an ambulatory basis, and without the need for neuroleptanalgesia.
Zero-Power Acoustic Wake-Up Receiver Based on DMUT Transmitter, PMUTS Arrays Receivers and MEMS Switches for Intrabody Links (2019)

This paper demonstrates, for the first time, a zero-power acoustic wake-up receiver for intrabody links, allowing Implanted Medical Devices (IMDs) to minimize the IDLE power consumption. This architecture is based on Directly Modulated Ultrasonic Transducers (dMUT) made of Lead Zirconate Titanate (PZT) as transmitter (TX), a Piezoelectric Micro Machined Ultrasonic Transducer (pMUT) array as receiver (RX), and a Micro Electro-Mechanical System (MEMS) switch. The role of the dMUTs and the pMUT array is to establish an acoustic link sensitive to signals as low as 50mV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> peak-peak at a distance of 10cm. This low signal triggers the switch which will turn on the IMDs from an IDLE-state to a full power mode.
Effects of Third Component on Hydrophobic and Hydrophilic Moities of Tryptophan in Aqueous Solution. Approach to Understanding of Denaturation of Globular Protein (1970)

The solubility properties of tryptophan were observed in various solutions of the denaturants for β-lactoglobulin reported by Tanford, et al., and the effects of such 3rd component on the hydrophobic and the hydrophilic moieties of solute molecule was discussed on the basis of the enthalpy of mixing. As a result, it seemed possible to classify the denaturants into three types according to the balance of the effects on hydrophobic and hydrophilic moieties of tryptophan resulting in a change of solubility. In comparison with the existing data, the same classification might be extended to the denaturants according to their effects on the denaturation of β-lactoglobulin, and it was established that the solubility of tryptophan or the denaturation of β-lactoglobulin varies with the effects of additive (or denaturant) on hydrophobic and hydrophilic moieties of molecule, where the decrease in enthalpy of mixing is considered to be a predominant factor to result in the increase in solubility of tryptophan or to result in the denaturation of β-lactoglobulin.
Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues (1992)

Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.
Impact of African Swine Fever on US and World Commodity Markets (2019)

Recent outbreaks of African Swine Fever (ASF) in Vietnam, Cambodia, Laos, South Korea, and especially China, have generated interest in how world commodity markets will adjust in response to pig herd losses due to the disease and to panic culling to avoid the negative impacts of the disease. This adjustment is complicated by the retaliatory duties of 25% and 60% that China has placed on US soybean and pork exports, respectively, and the duration of temporary exemptions on these tariffs on soybeans and pork. It is clear that a scarcity of pork will cause a reduction in pork consumption in impacted countries and a switch to alternative proteins. It is also clear that countries (such as the European Union and Brazil) who have direct access to China’s pork and chicken markets will see an increase in exports. What is less clear is the second-round impact of these adjustments. Will the United States ship more pork to markets vacated by the European Union and Brazil as these countries pursue lucrative markets in China? What is the net impact on US and world soybean and corn exports and prices? What would be the implications for the United States if China removes retaliatory duties?
An explicit solution for the energy-efficient cooperative transmission problem in wireless sensor networks (2013)

This paper considers low-complexity implementation of energy-efficient cooperative transmission in wireless sensor networks. In particular, an optimization framework is considered which, for a given configuration of the source, destination and relay nodes, performs optimal relay selection and power allocation subject to signal-to-noise ratio constraints. While the proposed framework gives the optimal solution, considering simple platforms of sensing nodes, solving the corresponding mixed-integer linear programming problem is computationally complex. To overcome this hurdle, an explicit solution to the optimization problem at hand is presented by invoking the theory of multi-parametric programming. This technique provides the solution as a function of measurable parameters in an off-line manner. The piecewise-constant values in such a solution can be stored in a memory chip and the online computational tasks are reduced to finding the parameters and evaluating simple functions to obtain the optimal solution.
Propagation simulation with the ParFlow method: fast computation using a multi-resolution scheme (2002)

The increase of potential applications of wireless networks in indoor environments calls for robust and efficient tools for predicting the wave propagation in such complex environments. The ParFlow technique is a discrete approach which accurately reflects the behavior of wave propagation but in turn requires very high computation and time resources. Initially this method has been implemented in a parallel architecture to reduce the computation time. A new resolution scheme is proposed to solve the discrete ParFlow equations. This approach is based on a multi-resolution formulation in the Fourier domain. The major result of our approach is that the computation complexity may be settled in two parts. Firstly, the multi-resolution pyramid is built (taking into account the geometry arrangement of the indoor environment). Secondly, the propagation from a point source is evaluated through the soft pyramidal architecture with a high gain in terms of computational efficiency. We guess that this approach could increase the interest of the ParFlow technique which could be more accurate than ray-tracing methods at least in a theoretical point of view.
Design Development of Rotational Energy Harvesting Vibration Absorber (R-EHTVA) (2018)

This paper proposes a novel idea of a combined piezoelectric energy harvesting and torsional vibration absorber for rotating system. In particular, among possible alternative solutions for durable power sources useable in mechanical components, vibration represents a suitable method for the amount of power required to feed a wireless sensor network. For this purpose energy harvesting from structural vibration has received much attention in the past few years. Suitable vibration can be found in numerous mechanical environments including automotive moving structures, household applications, but also buildings and bridges. Similarly, a dynamic vibration absorber (DVA) is one of the most used devices to mitigate the vibration structures. This device is used to transfer the primary structural vibration to the auxiliary system. Thus, vibration energy is effectively localized in the secondary less sensitive structure and it can be harvested. This paper describes the design process of an energy harvesting tuned vibration absorber for rotating system using piezoelectricity components. Instead of being dissipated as heat, the energy of vibration is converted into electricity. The device proposed is designed to mitigate torsional vibrations as a rotational vibration absorber and to harvest energy as a power source for immediate use. The initial rotational multi degree of freedom system is initially reduced in equivalent single degree of freedom (SDOF) systems. An optimization method is used for evaluating the optimal mechanical parameters of the initial absorber for the SDOF systems defined. The design is modified for the integration of the active patches without detuning the absorber. In order to estimate the real power generated, a complex storage circuit is implemented. A fixed voltage is obtained as output. Through the introduction of a big capacitor, the energy stored is measured at different frequencies. Finally, the simultaneously achievement of the vibration reduction function and the energy harvesting function is evaluated.
Image deconvolution by nonlinear signal processing (1989)

We describe a nonlinear optical processor that can perform image deconvolution to restore a smeared or out-of-focus image. In this technique both the smeared image and the blur function are displayed side by side at the input plane of the processor. The joint power spectrum of the input signals is modified and hard clipped/ thresholded to remove the amplitude distortion effects and to restore the correct phase of the original image. The phase information is restored by multiplying the Fourier transform of the blurred image by the conjugate of the phase of the blur function transform. An amplitude mask averaged over an ensemble of images is assigned to the thresholded power spectrum to provide the amplitude magnitude of the restored image. An analysis of the nonlinear processor for image deconvolution is presented. Computer simulation of the proposed technique for a linearly smeared image is provided.
The Nonparametric Adaptive Grid Algorithm for Population Pharmacokinetic Modeling (2013)

The nonparametric adaptive grid (NPAG) algorithm is described. NPAG is a primal dual interior point method for determining the nonparametric maximum likelihood distribution of random parameters for a nonlinear regression model. In pharmacokinetic (PK) population modeling, NPAG is useful for the case where a series of measurements are made on diverse individuals, distinguished by diverse measurement conditions. This paper includes sufficient mat hematical background and program detail to allow computational scientists to translate NPAG from PK
Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis (2017)

Blood coagulation functions as part of the innate immune system by preventing bacterial invasion, and it is critical to stopping blood loss (hemostasis). Coagulation involves the external membrane surface of activated platelets and leukocytes. Using lipidomic, genetic, biochemical, and mathematical modeling approaches, we found that enzymatically oxidized phospholipids (eoxPLs) generated by the activity of leukocyte or platelet lipoxygenases (LOXs) were required for normal hemostasis and promoted coagulation factor activities in a Ca<sup>2+</sup>- and phosphatidylserine (PS)-dependent manner. In wild-type mice, hydroxyeicosatetraenoic acid-phospholipids (HETE-PLs) enhanced coagulation and restored normal hemostasis in clotting-deficient animals genetically lacking p12-LOX or 12/15-LOX activity. Murine platelets generated 22 eoxPL species, all of which were missing in the absence of p12-LOX. Humans with the thrombotic disorder antiphospholipid syndrome (APS) had statistically significantly increased HETE-PLs in platelets and leukocytes, as well as greater HETE-PL immunoreactivity, than healthy controls. HETE-PLs enhanced membrane binding of the serum protein β2GP1 (β2-glycoprotein 1), an event considered central to the autoimmune reactivity responsible for APS symptoms. Correlation network analysis of 47 platelet eoxPL species in platelets from APS and control subjects identified their enzymatic origin and revealed a complex network of regulation, with the abundance of 31 p12-LOX-derived eoxPL molecules substantially increased in APS. In summary, circulating blood cells generate networks of eoxPL molecules, including HETE-PLs, which change membrane properties to enhance blood coagulation and contribute to the excessive clotting and immunoreactivity of patients with APS.
Isometric multi-signature multi-user MC-CDMA in frequency-selective fading (2004)

We characterize the asymptotic spectral efficiency of the linear minimum mean squared error (LMMSE) receiver for multiuser multisignature multicarrier (MC) code-division multiple access (CDMA) communication systems. We consider signatures which are orthogonal at each transmitter. Our results are asymptotic as the number of signatures per user and processing gain both tend to infinity with fixed ratio. Our results rely on approximating covariance matrices with unitarily invariant matrices that are asymptotically free.
Selective targeting of PI3Kδ suppresses human IL-17-producing T cells and innate-like lymphocytes and may be therapeutic for IL-17-mediated diseases (2020)

The delta isoform of phosphoinositide 3-kinase (PI3Kδ) regulates various lymphocyte functions. Considering the key pro-inflammatory role of IL-17A and IL-17F cytokines in psoriasis and spondyloarthritis (SpA), we investigated the potential of PI3Kδ blockade to suppress IL-17A, IL-17F and associated pro-inflammatory cytokines that could synergize with IL-17A and IL-17F. Using in vitro studies with primary human cells and ex vivo studies with inflamed target tissues, we assessed if seletalisib, a selective PI3Kδ inhibitor, suppresses cytokine production by T cells and innate-like lymphocytes, and if seletalisib modulates the inflammatory responses in stromal cell populations in psoriasis (human dermal fibroblasts (HDF)) and SpA (fibroblast-like synoviocytes (FLS)). In vitro, seletalisib inhibited the production of pro-inflammatory cytokines, including IL-17A and IL-17F, from peripheral blood mononuclear cells (PBMCs), T helper 17 (Th17) cells as well as γδ-T cells and mucosal-associated invariant T cells. This inhibition resulted in decreased inflammatory activation of HDF in co-culture systems. Seletalisib was also efficacious in inhibiting SpA PBMCs and synovial fluid mononuclear cells (SFMCs) from producing pro-inflammatory cytokines. Furthermore, supernatant derived from cultured seletalisib-treated Th17 cells showed reduced potency for activating inflammatory responses from cultured SpA FLS and decreased their osteogenic differentiation capacity. Finally, analysis of inflamed SpA synovial tissue biopsies revealed activation of the PI3K-Akt-mTOR pathway. We observed that ex vivo seletalisib treatment of inflamed synovial tissue reduced IL-17A and IL-17F expression. Collectively, inhibition of PI3Kδ reduces the production of pro-inflammatory cytokines from IL-17-producing adaptive and innate-like lymphocytes and thereby inhibits downstream inflammatory and tissue remodeling responses. PI3Kδ-targeting may therefore represent a novel therapeutic avenue for the treatment of IL-17-mediated chronic inflammatory diseases such as psoriasis and SpA.
Olfactory Epithelium Grafts in the Cerebral Cortex: An Immunohistochemical Analysis (2001)

Studies of olfactory neuron regeneration have been limited by the inability to produce cultures with long-term viability. Olfactory epithelial grafts to the cerebral cortex provide an alternative approach to the study of olfactory neuron regeneration.
A 5 GHz, 1 mW CMOS voltage controlled differential injection locked frequency divider (2003)

A voltage controlled differential injection locked frequency divider (VCDILFD) with a large locking range is designed in a 0.24 /spl mu/m CMOS technology. A 29% locking range is achieved by an optimal inductor design and also by employing high Q accumulation mode MOS varactors to change the free-running oscillation frequency of the divider. The measurement results show frequency division at 5 GHz, with more than 1 GHz locking range and power consumption of less than 1 mW.
Synthesis and Structure−Activity Relationships of Trisubstituted Phenyl Urea Derivatives as Neuropeptide Y5 Receptor Antagonists (2001)

1-((1R,2R)-2-Hydroxy-1-methyl-2-phenylethyl)-1-methyl-3-(4-phenoxyphenyl)urea (1) was identified as a hit from the screening of the neuropeptide Y5 (NPY5) receptor. This lead was optimized for in vitro potency by changing the stereochemistry, the phenylethyl segment, the urea portion, and the 4-phenoxyphenyl group on the molecule. Over 40 analogues of 1 were prepared to study the structure-activity relationship for this series. The most potent compounds in this class have IC(50)s less than 0.1 nM at the NPY5 receptor (e.g., 40f, 44a, and 47). To determine the functional activity for this series of compounds, selected analogues were tested in a cellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor. All urea analogues tested in the functional assay acted as antagonists (e.g., 1, 32, 40a, and 44e).
Epidemiology of intentional self-poisoning in rural Sri Lanka (2005)

We investigated the epidemiology of intentional self-poisoning in rural Sri Lanka by prospectively recording 2189 admissions to two secondary hospitals. Many patients were young (median age 25 years), male (57%) and used pesticides (49%). Of the 198 who died,156 were men (case fatality 12.4%) and 42 were women (4.5%). Over half of female deaths were in those under 25 years old; male deaths were spread more evenly across age groups. Oleander and paraquat caused 74% of deaths in people under 25 years old; thereafter organophosphorous pesticides caused many deaths. Although the age pattern of self-poisoning was similar to that of industrialised countries, case fatality was more than 15 times higher and the pattern of fatal self-poisoning different.
Enhancing 802.11 Wireless Networks with Directional Antenna and Multiple Receivers (2006)

When directional antennas are used in 802.11 based wireless LANs, higher network capacity is often accompanied with more collisions. This is due to the enhanced hidden node problem and the deafness problem that arise in the directional transmission/reception scenario. These problems are caused by an inconsistent view of the medium status by neighboring nodes. We have developed a new variation to the 802.11 protocol called sectorized MAC (S-MAC), which employs a novel architecture consisting of multiple directional antennas and multiple receivers. With a new self-interference cancellation scheme, an S-MAC node can continuously monitor the channel status in all directions in order to avoid the aforementioned problems. It is fully compatible with the standard 802.11 protocol and can inter-operate with omni-antenna-based 802.11 nodes. It is applicable to both infrastructure mode and ad hoc mode. Simulation studies show that it achieves significant capacity gains, even if only used in part of the network.
Ghrelin Receptor Agonists in Cachexia of Human Aging (2012)

Frailty is one of the key features of aging and it is associated with a loss of function, an increased risk of falls, and ultimately loss of the ability to live independently. Based on the demographic shift of the older population, as a result of the aging of the baby boomers, interventions to slow or delay the development of frailty will be of increasing importance. One of the physiologic correlates of frailty is the cachexia of aging. The underlying mechanism of the cachexia of aging is cytokine-associated wasting of protein and energy stores and ghrelin receptor agonists target some of these mechanisms. Clinical trials have shown that ghrelin receptor agonists have orexigenic effects, enhance GH secretion, and increase lean body mass and limb fat mass in the elderly. The potential benefits of ghrelin receptor agonists in the treatment of cachexia of aging and of cachexia secondary to various diseases are reviewed.
Research of TDOA Based Self-localization Approach in Wireless Sensor Network (2006)

Sensor network, which has integrated wireless communication, date collection and information processing capacities, is a booming technique in information collecting. With the development of research on wireless sensor networks (WSNs), localization in the WSNs has become a very important research point. At present, there are mainly two kinds of approaches, range-based approach and range-free approach. Localization precision of range-based approach is higher than the range-free approach. In the range-based approach, time difference of arrival (TDOA) method needs less requirements for time synchronization. This paper proposes a self-localization approach based on TDOA, which utilizes average value of time difference by rolling average to decrease the measurement error, and adopts unconstrained least squares (LS) estimator to achieve the accurate localization. Simulation results and error analysis prove its validity