gebhart/patrepeval huggingface dataset:
<title>Confocal scanning beam laser microscope/macroscope: applications in fluorescence</title> (1996)

A new confocal scanning beam laser microscope/macroscope is described that combines the rapid scan of a scanning beam laser microscope with the large specimen capability of a scanning stage microscope. This instrument combines an infinity-corrected confocal scanning laser microscope with a scanning laser macroscope that uses a telecentric f*(Theta) laser scan lens to produce a confocal imaging system with a resolution of 0.25 microns at a field of view of 25 microns and 5 microns at a field of view of 75,000 microns. The frame rate is 5 seconds per frame for a 512 by 512 pixel image, and 25 seconds for a 2048 by 2048 pixel image. Applications in fluorescence are discussed that focus on two important advantages of the instrument over a confocal scanning laser microscope: an extremely wide range of magnification, and the ability to image very large specimens. Examples are presented of fluorescence and reflected-light images of high quality printing, fluorescence images of latent fingerprints, packaging foam, and confocal autofluorescence images of a cricket.
Increase in Colony-Forming Unit of Bacterial Communities in Aquatic Environments by Supplementation with Sodium Pyruvate. (2000)

It has been reported that higher plate counts for bacterial communities in river epilithon were yielded on agar plates by supplementation with sodium pyruvate, compared to the counts without supplementation.To support the credibility of this phenomenon, studies were conducted regarding the bacterial communities in several aquatic environments.Consequently, degrees of the ratio of colony-forming unit(CFU)on agar plates supplemented with sodium pyruvate to that without supplementation were grouped into two categories:a 2 to 3 magnitude group and a 5 to 6 magnitude one.According to cluster analysis of the water quality, higher degrees of the ratio were observed at environments that had a DOC concentration around 1ppm and had a low NO3- concentration.The compositions of the abundantly-appearing bacterial colonies were suggested to be different from that of those appearing on the agar plates without supplementation of sodium pyruvate.
Supplementary Table 2 from Expression of Interleukin-4 Receptor Alpha in Human Pleural Mesothelioma Is Associated with Poor Survival and Promotion of Tumor Inflammation (2023)

&lt;p&gt;PDF file - 49K&lt;/p&gt;
A Brownian Dynamics Study of the Initial Stages of Hen Egg-White Lysozyme Adsorption at a Solid Interface (2001)

We investigate the initial stages of hen egg-white lysozyme (HEWL) adsorption at a charged solid interface using Brownian Dynamics simulation. The protein is modeled at the atomistic level and the adsorption surface is represented by a planar array of positively charged sites. Adsorption reactions are simulated at neutral pH and at low and high salt concentrations. We find that the HEWL, which has a net positive charge, can adsorb onto the positively charged surface. The results are consistent with an electrostatically driven adsorption process. While the orientational distribution of the adsorbed protein is nonuniform, there is no dominant patch composed of two or more oppositely charged residues. The electric field distribution around the protein is the best predictor of the adsorption behavior.
İki Farklı Lokasyona ait Altın Otunun (Helichrysum arenarium) Uçucu Bileşenlerinin Belirlenmesi ve Karşılaştırılması (2020)

Bu çalışmada, 2019 yılı Haziran-Ağustos ayında iki farklı bölgede toplanan Altın Otunun ( Helichrysum arenarium ) Katı Faz Mikro Ekstraksiyon (SPME) yöntemi kullanılarak uçucu bileşenleri Gaz Kromatografisi-Kütle Spektroskopisi (GC-MS) ile belirlendi. Bitlis Nemrut Krater Gölü çevresindeki Altın Otu örneğinde toplam 21 adet uçucu bileşen tespit edilirken, Giresun’un Şebinkarahisar İlçesi’nin dağlık bölgelerindeki Altın Otu örneğinde toplam 33 adet uçucu bileşen tespit edildi. Bitlis Nemrut Krater Gölü çevresindeki Altın Otunda α-sedren (% 26.65), α-pinen (% 14.97), α-humulen (% 10.65), aromadendren (% 6.79), α-kurkumen (% 6.31), germakren B (% 4.43), α-kadinen (% 3.82), ökaliptol (% 3.57), α-duprezianen (% 3.57) ve limonen (% 2.69) uçucu ana bileşen olarak tespit edilirken, Giresun Şebinkarahisar İlçesinin dağlık alanlarındaki Altın Otuna ait örnekte α-pinen (% 47.63), α-himakhalen (% 17.01), α-humulen (% 5.21), δ-kadinen (% 4.98), γ-kadinen (% 4.01) ve ökaliptol (% 3.46) uçucu ana bileşen olarak tespit edildi.
Effects of cigarette and biomass smoke exposure on oxidant–antioxidant status in rabbits (2006)

To evaluate the effects of cigarette smoking and biomass (dried dung) smoke on the oxidant–antioxidant status, three groups each with 5 rabbits were used. Groups of rabbits were exposed to either cigarette smoke, dried dung smoke or dry air, 1 h daily for one month. Protein carbonyls, prostaglandin F2α and malondialdehyde levels were significantly increased and protein sulfhydryls levels were significantly decreased in the cigarette smoke group compared with the control group. Only protein sulfhydryls levels were significantly decreased in dung group compared with the control group. Short course exposure to both cigarette smoke and biomass smoke decreased plasma antioxidant levels but only cigarette smoke increased plasma oxidant levels, whereas biomass smoke did not produce any change.
Deconvoluting complex tissues for expression quantitative trait locus-based analyses (2013)

Breast cancer genome-wide association studies have pinpointed dozens of variants associated with breast cancer pathogenesis. The majority of risk variants, however, are located outside of known protein-coding regions. Therefore, identifying which genes the risk variants are acting through presents an important challenge. Variants that are associated with mRNA transcript levels are referred to as expression quantitative trait loci (eQTLs). Many studies have demonstrated that eQTL-based strategies provide a direct way to connect a trait-associated locus with its candidate target gene. Performing eQTL-based analyses in human samples is complicated because of the heterogeneous nature of human tissue. We addressed this issue by devising a method to computationally infer the fraction of cell types in normal human breast tissues. We then applied this method to 13 known breast cancer risk loci, which we hypothesized were eQTLs. For each risk locus, we took all known transcripts within a 2 Mb interval and performed an eQTL analysis in 100 reduction mammoplasty cases. A total of 18 significant associations were discovered (eight in the epithelial compartment and 10 in the stromal compartment). This study highlights the ability to perform large-scale eQTL studies in heterogeneous tissues.
Gate Diffusion Input (GDI) logic in standard CMOS nanoscale process (2010)

In this paper CMOS compatible Gate Diffusion Input (GDI) design technique is proposed. The GDI method enables the implementation of a wide range of complex logic functions using only two transistors. This method is suitable for the design of low-power logic gates, with a much smaller area than Static CMOS and existing PTL techniques. As opposite to our originally proposed GDI logic, the modified GDI logic is fully compatible for implementation in a standard CMOS process. Simulations of basic GDI gates under process and temperature corners in 40nm CMOS process are shown and compared to similar CMOS gates. We show that while having the same delay, GDI gates achieve leakage and active power reduction of up to 70% and 50%, respectively.
13.4: Subpixel Image Scaling for Color Matrix Displays (2002)

Abstract The apparent resolution of matrix displays is increased when the relative position of the color subpixels is taken into account. This paper shows that a general method to achieve this for any subpixel arrangement, can be incorporated in an image scaler at low additional cost, allowing simple quality trade‐off control.
Immunoinformatics approaches to explore Helicobacter Pylori proteome (Virulence Factors) to design B and T cell multi-epitope subunit vaccine (2019)

Helicobacter Pylori is a known causal agent of gastric malignancies and peptic ulcers. The extremophile nature of this bacterium is protecting it from designing a potent drug against it. Therefore, the use of computational approaches to design antigenic, stable and safe vaccine against this pathogen could help to control the infections associated with it. Therefore, in this study, we used multiple immunoinformatics approaches along with other computational approaches to design a multi-epitopes subunit vaccine against H. Pylori. A total of 7 CTL and 12 HTL antigenic epitopes based on c-terminal cleavage and MHC binding scores were predicted from the four selected proteins (CagA, OipA, GroEL and cagA). The predicted epitopes were joined by AYY and GPGPG linkers. Β-defensins adjuvant was added to the N-terminus of the vaccine. For validation, immunogenicity, allergenicity and physiochemical analysis were conducted. The designed vaccine is likely antigenic in nature and produced robust and substantial interactions with Toll-like receptors (TLR-2, 4, 5, and 9). The vaccine developed was also subjected to an in silico cloning and immune response prediction model, which verified its efficiency of expression and the immune system provoking response. These analyses indicate that the suggested vaccine may produce particular immune responses against H. pylori, but laboratory validation is needed to verify the safety and immunogenicity status of the suggested vaccine design.
Transcriptome Sequencing and Metabolism Analysis Reveals the role of Cyanidin Metabolism in Dark-red Onion (Allium cepa L.) Bulbs (2018)

Onion (Allium cepa L.) is an important bulbous vegetable crop that possesses important properties related to health as well as extraordinary colors. Naturally white onion bulbs were used in this study to reveal the complex metabolic mechanisms that underlie phenotypic traits, especially bulb pigmentation. Six libraries (three dark-red and three white) were constructed and analyzed to elucidate differences in cyanidin (Cy) metabolism between dark-red and white onion bulbs. Libraries were screened using RNA-sequencing (RNA-seq) to reveal the differentially expressed genes (DEGs) involved in anthocyanin biosynthesis at the transcriptional level. Comparison with the Kyoto Encyclopedia of Genes and Genomes (KEGG) database shows that a total of 27 unigenes participate in onion anthocyanin biosynthesis and 16 DEGs perform critical roles in flavonoid biosynthesis. Expression patterns of color-related flavonoid compounds associated with the onion anthocyanin biosynthesis pathway (ABP) show that flavonoid 3',5'-hydroxylase (F3'5'H) and dihydroflavonol 4-reductase (DFR) genes play crucial roles in the biosynthesis of dark-red bulbs, the expression levels of flavonol synthase (FLS) and DFR genes may act to block blue pigmentation, and the loss of Cy from white onion bulbs might explain multibranching in the synthesis of this compound. Positive variation in the F3'5'H/F3'H ratio also affects onion bulb color diversity. The transcriptome presented here provides a basis for future onion molecular breeding based on variations in the diversity of ornamental plant pigmentation.
Wavelet Frames: an Alternative to Spherical Harmonic Representation of Potential Fields? (2004)

Potential fields are classically represented on the sphere using spherical harmonics. However, this decomposition leads to numerical difficulties when data to be modelled are irregularly distributed or cover a regional zone. To overcome this drawback, we develop a new representation of the magnetic and the gravity fields based on wavelet frames. In this paper, we first describe how to build wavelet frames on the sphere. The chosen frames are based on the Poisson multipole wavelets, which are of special interest for geophysical modelling, since their scaling parameter is linked to the multipole depth (Holschneider et al.). The implementation of wavelet frames results from a discretization of the continuous wavelet transform in space and scale. We also build different frames using two kinds of spherical meshes and various scale sequences. We then validate the mathematical method through simple fits of scalar functions on the sphere, named 'scalar models'. Moreover, we propose magnetic and gravity models, referred to as 'vectorial models', taking into account geophysical constraints. We then discuss the representation of the Earth's magnetic and gravity fields from data regularly or irregularly distributed. Comparisons of the obtained wavelet models with the initial spherical harmonic models point out the advantages of wavelet modelling when the used magnetic or gravity data are sparsely distributed or cover just a very local zone
On-Orbit System Identification Experiments of the Engineering Test Satellite-VIII (2009)

This paper presents the results of on-orbit system identification of the Engineering Test Satellite-VIII (ETS-VIII), which was launched by the H-IIA Launch Vehicle No. 11 in December 2006. On-orbit system identification experiments were performed using data acquired during normal operations in the initial check-out phase, such as station acquisition and wheel unloading. The satellite's unconstrained modes were identified using attitude rates and data from accelerometers located on the main body, solar array paddles and large deployable antenna reflectors at various solar array paddle angles. In addition, the constrained modal parameters of the solar array paddles and large deployable antenna reflectors were estimated for comparison with the analytical model.
Critical fluctuations near the smectic-hexatic phase transition with anticlinic structure (2002)

Layer compression modulus B measurements have been conducted near the transitions between smectic and hexatic phases with synclinic and anticlinic structures. In the synclinic structure, B shows no pretransitional softening near the phase transition. However, in the anticlinic structure, we observed evident critical softening of B near the smectic-hexatic phase transition. These results clearly reveal that the introduction of the in-plane hexatic order in the anticlinic structure is different from the usual smectic-hexatic phase transition.
Improved outcome with fluid restriction in treatment of uncontrolled hemorrhagic shock. (1995)

Attempts to achieve normal MAP during uncontrolled bleeding increased blood loss, hemodilution and mortality. Hypotensive resuscitation resulted in less acidemia and improved long-term survival.
Carcinogenicity, mutagenicity and cancer preventing activities of flavonoids: A structure-system-activity relationship (SSAR) analysis (1994)

Flavonoids and related phenolic compounds are widely distributed among vascular plants and are found in numerous fruits, grains vegetables and other parts of higher plants [1–3]. Isolation and structural determination of flavonoids have been employed in plant taxonomy [1, 2]. Because of the wide range of chemical structures of flavonoids, coupled with a variety of test systems and different dose levels used, sometimes conflicting reports have been published in the literature regarding their numerous pharmacological and toxicological activities. This prompted us to conduct a literature survey and a structure-system-activity-relationship (SSAR) analysis of existing data, with particular emphasis on the carcinogenicity/mutagenicity and cancer preventive aspects of the flavonoids.
Computer aided diagnosis (CAD) of breast mass on ultrasonography and scintimammography (2005)

Both breast ultrasonography (US) and scintimammography (SMM) shows limited diagnostic accuracy in the differential diagnosis of breast cancer. We investigated whether the diagnostic performance of computer-aided diagnosis (CAD) of US was improved by adding SMM results. We retrospectively reviewed 40 breast US images and corresponding SMM images from 40 patients who presented with breast masses (21 malignant and 19 benign tumors). The morphologic features of the breast lesions on US were extracted and quantitated using the automated CAD software program (So no Eye, CAD Impact, Inc., Seoul, Korea), which calculated the probability of malignancy based on the stored database. The quantitative data of SMM were obtained as the uptake ratio of lesion to contralateral normal breast on SMM SPECT. The diagnostic accuracy of CAD of US and SMM was determined using ROC curve analysis, respectively. The best discriminating function combining the CAD results of US and SMM uptake value was created using linear discriminant analysis and the diagnostic performance was compared to that using only one diagnostic modality. Both US and SMM showed a relatively good diagnostic accuracy (area under curve=0.831 and 0.846, respectively). Combining CAD results of US and SMM resulted in improved diagnostic accuracy (area under curve =0.860), but it was not statistically significant. The diagnostic performance of CAD of breast US in the differential diagnosis of the breast mass was not significantly improved by adding SMM. However, SMM SPECT may be complementary to CAD of US in differential diagnosis of breast cancer.
Performance of random-wavelength switching of three-electrode DBR laser with packet headers used for routing (1992)

The performance of random-wavelength switching of a wavelength-tunable three-electrode DBR laser is demonstrated. Packet header information is used to randomly switch the currents of the laser and route 155Mbit/s data packets onto four different wavelength modes. BERs of 10−9 are achieved over a 4.8nm tuning range with a packet guard time &lt;25ns and a packet holding time &gt;3 μs. Modepartition noise and mode hopping are not degrading factors under random-wavelength-switching conditions.
Predicting the behavior of interacting humans by fusing data from multiple sources (2014)

Multi-fidelity methods combine inexpensive low-fidelity simulations with costly but highfidelity simulations to produce an accurate model of a system of interest at minimal cost. They have proven useful in modeling physical systems and have been applied to engineering problems such as wing-design optimization. During human-in-the-loop experimentation, it has become increasingly common to use online platforms, like Mechanical Turk, to run low-fidelity experiments to gather human performance data in an efficient manner. One concern with these experiments is that the results obtained from the online environment generalize poorly to the actual domain of interest. To address this limitation, we extend traditional multi-fidelity approaches to allow us to combine fewer data points from high-fidelity human-in-the-loop experiments with plentiful but less accurate data from low-fidelity experiments to produce accurate models of how humans interact. We present both model-based and model-free methods, and summarize the predictive performance of each method under dierent conditions.
Satellite Symposium on Cabergoline (Farmitalia - Carlo Erba) (1990)

Journal Article Satellite Symposium on Cabergoline (Farmitalia - Carlo Erba) Get access E. di Salle E. di Salle Oncology Line, R&D, Farmitalia Carlo Erba , Nerviano (Mi), Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction, Volume 5, Issue Supplement, 1 November 1990, Page 127, https://doi.org/10.1093/humrep/5.Supplement.127 Published: 01 July 1990
Nonintrusive Biosignal Measurement System in a Vehicle (2007)

Measurement of driver's state is important in both daily healthcare and prevention of car accidents. Existing measurement methods, however, are too complex and uncomfortable to measure for everyday. A nonintrusive biosignal monitoring system is demanded for increasing the accessibility. In this paper, we proposed a nonintrusive measurement system integrated in a vehicle for recording electrocardiographic (ECG) signals and tested the performance of the system. The system consists of dry electrodes attached to the steering wheel and a wireless communication module using a Bluetooth device. ECG signals measured by our system were compared with those by a conventional system employing wet electrodes during real city road driving. Various parameters used for HRV analysis in time and frequency domain showed no significant differences between the two simultaneously measured ECG signals. The result implies the possibility that developed system could have a potential to monitor health information in a vehicle instead of commercial equipments.
Deformation Microstructures in a Two-Phase Stainless Steel during Large Strain Deformation (2006)

Deformation microstructures were studied in a two-phase (about 60% ferrite and 40% austenite) Fe – 27%Cr – 9%Ni stainless steel. Severe plastic working was carried out by rolling from 21.3×21.3 mm2 to 7.8×7.8 mm2 square bar followed by swaging from Ø7.0 to 0.6 mm rod at an ambient temperature, providing a total strain of 6.9. After a rapid increase in the hardness at an early deformation, the rate of the strain hardening gradually decreased to almost zero at large strains above 4. In other words, the hardness approached a saturation level, leading to an apparent steadystate deformation behaviour during cold working. The severe deformation resulted in the evolution of highly elongated (sub)grains aligned along the rolling/swaging axis with the final transverse (sub)grain size of about 0.1 μm and the fraction of high-angle (sub)boundaries above 60%. However, the kinetics of microstructure evolution in the two phases was different. In the ferrite phase, the transverse size of deformation (sub)grains gradually decreased during the processing and approached 0.1 μm at strains of about 6.0, while the transverse size of the austenite (sub)grains rapidly reduced to its final value of 0.1 μm after a relatively low strain about 1.0.
Organocatalytic Phosphonylation of in Situ Formed o-Quinone Methides (2017)

A new class of Brønsted acid catalysts based on N-heterocyclic phosphorodiamidic acids (NHPAs) has been developed. The NHPA catalyst promotes phospha-Michael addition reaction of trialkylphosphites to in situ generated ortho-quinone methides (o-QMs) for the construction of diaryl phosphonates in moderate to excellent yields with 1.5 mol % catalyst. Diastereoselective synthesis of P-chiral phosphinate esters is achieved with the use of dialkyl phenylphosphonites.
Early Neolithic genomes from the eastern Fertile Crescent (2016)

We sequenced Early Neolithic genomes from the Zagros region of Iran (eastern Fertile Crescent), where some of the earliest evidence for farming is found, and identify a previously uncharacterized population that is neither ancestral to the first European farmers nor has contributed substantially to the ancestry of modern Europeans. These people are estimated to have separated from Early Neolithic farmers in Anatolia some 46,000 to 77,000 years ago and show affinities to modern-day Pakistani and Afghan populations, but particularly to Iranian Zoroastrians. We conclude that multiple, genetically differentiated hunter-gatherer populations adopted farming in southwestern Asia, that components of pre-Neolithic population structure were preserved as farming spread into neighboring regions, and that the Zagros region was the cradle of eastward expansion.