gebhart/patrepeval huggingface dataset:
Unconditional security of Gaussian post-selected continuous variable quantum key distribution (2013)

Continuous Variable (CV) Quantum Key Distribution (QKD) has the advantage of high raw bit rates due to the high efficiency and high bandwidth of homodyne detection and ease of integration with existing communications infrastructure. CV protocols that employ Post-Selection (PS) [1] - a classical filtering of the measurement results - enjoy additional advantages in terms of versatility and reconciliation efficiency.
The Static and Stochastic Vehicle Routing Problem with Time Windows and both random Customers and Reveal Times (abstract) (2016)

International audience
Self‐Assembled Arrays of Dendrimer–Gold‐Nanoparticle Hybrids for Functional Cell Studies (2011)

Kontrolliertes Zellwachstum: Ein Hybridmaterial aus Dendrimeren und Nanogoldpartikeln (siehe Abbildung; PEG=Polyethylenglycol) mit kontrollierter effektiver Oberflächenkonzentration des Dendrimers wurde in Zelladhäsionsstudien verwendet. Die Wirkung der makromolekularen Architektur auf das Anlagerungsverhalten und die Morphologieänderung der Endothelzellen wurde betrachtet. Höchstwahrscheinlich aufgrund unterschiedlicher Wechselwirkungen mit den Zellproteinen übertraf das Dendrimer ein lineares Pendant. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Human T-cell leukemia virus type I tax/rex DNA and RNA in cutaneous T- cell lymphoma (1994)

Peripheral blood mononuclear cells (PBMCs) and T-cell lines from patients with Sezary syndrome (SS) and skin lesions from patients with mycosis fungoides (MF) were examined by polymerase chain reaction (PCR) for DNA sequences homologous to the human retroviruses human T- lymphotropic virus (HTLV)-I and -II. Results obtained using primers and probes from the tax/rex region of HTLV-I indicate that 72% (18/25) of SS patients PBMCs, 80% (20/25) of T-cell lines established from SS- PBMC, and 30% (3/10) of skin lesions from MF patients were positive for HTLV-I tax/rex region DNA. Sequence analysis of the 127-bp fragment amplified by the tax/rex primers from 4 of these individuals was found to be identical to that in prototypic HTLV-I. Negative results were obtained using primers and probes from the HTLV-I gag region and the HTLV-II gag and tax regions. No PCR products were obtained using all primers and probes using DNA from 9 healthy blood donors and 10 cord bloods. Expression of HTLV-I tax/rex mRNA was found in 4 of 8 Sezary patients, as determined by RNA-PCR, indicating that this viral region is being transcribed in vivo. Exposure to Tax/Rex protein in SS- patients is supported by the fact that serum antibodies against p27rex and p40tax was observed in 43% and 29% of these SS patients, respectively. Although the causal relationship between the HTLV-I tax/rex region and cutaneous T-cell lymphoma (CTCL) remains unclear, these findings support the presence of a truncated HTLV-I retrovirus in CTCL patients.
Computation of Velocity and Temperature Distributions in Extrusion Dies (2003)

No AccessExtrusion Dies for Plastics and RubberAug 2003Computation of Velocity and Temperature Distributions in Extrusion DiesWalter MichaeliWalter Michaelihttps://doi.org/10.3139/9783446401815.004SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2003Pages: 77-139Print ISBN: 978-3-446-22561-9eISBN: 978-3-446-40181-5 Copyright & Permissions© 2003 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Removal of bronchoalveolar cells augments the late eosinophilic response to segmental allergen challenge (2002)

Background In patients with quiescent asthma, macrophages are the most prevalent cells recovered by bronchoalveolar lavage (BAL). Through activation via their FcεRII receptors or by acting as antigen‐presenting cells, macrophages could, in theory, promote the late airway response to allergen. Objective In order to investigate the importance of macrophages and other airway luminal cells in inducing the late airway response, a novel washout experiment was designed. Methods Five patients with ragweed‐allergic asthma underwent bronchoscopy and segmental bronchial challenge with either normal saline or short ragweed extract in two segments of one lung. In a third segment of the opposite lung, 12 successive BALs (25 mL each) were performed, followed by challenge with an identical dose of short ragweed (washed‐challenged segment). After 24 h, all three challenged segments underwent BAL. Results Initially, in the washed‐challenged segment, over 80% (mean 80.4%, range 68–88%) of the recoverable airway dwelling cells were removed. Unexpectedly, 24 h later these same washed‐challenged segments contained more eosinophils in the BAL than the challenged segments from the opposite lung ( P = 0.033). Conclusions Removing the majority of airway luminal cells followed by allergen bronchoprovocation increased the number of eosinophils recovered 24 h after challenge. Our results suggest that in quiescent allergic asthma, the airway luminal cells are protective and attenuate the late eosinophilic response to allergen challenge.
Proneurogenic and neuroprotective effect of a multi strain probiotic mixture in a mouse model of acute inflammation: Involvement of the gut-brain axis (2021)

Neuroinflammation can severely affect brain homeostasis and adult hippocampal neurogenesis with detrimental effects on cognitive processes. Brain and gut are intimately connected via the "gut-brain axis", a bidirectional communication system, and the administration of live bacteria (probiotics) has been shown to represent an intriguing approach for the prevention or even the cure of several diseases. In the present study we evaluated the putative neuroprotective effect of 15-days consumption of a multi-strain probiotic formulation based on food-associated strains and human gut bacteria at the dose of 10<sup>9</sup> CFU/mouse/day in a mouse model of acute inflammation, induced by an intraperitoneal single injection of LPS (0.1 mg/kg) at the end of probiotic administration. The results indicate that the prolonged administration of the multi-strain probiotic formulation not only prevents the LPS-dependent increase of pro-inflammatory cytokines in specific regions of the brain (hippocampus and cortex) and in the gastrointestinal district but also triggers a potent proneurogenic response capable of enhancing hippocampal neurogenesis. This effect is accompanied by a potentiation of intestinal barrier, as documented by the increased epithelial junction expression in the colon. Our hypothesis is that pre-treatment with the multi-strain probiotic formulation helps to create a systemic protection able to counteract or alleviate the effects of LPS-dependent acute pro-inflammatory responses.
A cloudlet-based multi-lateral resource exchange framework for mobile users (2015)

The hardware improvement of mobile devices and pervasiveness of wireless technology expedite the convergence with the fast growing cloud computing trend, where the abundant resources on the cloud meet well with the deficiency of hand-held devices. Cloudlet, as a newly emerging paradigm “bringing the cloud closer” to the end users, features a more scalable deployment fashion where idle personal servers can be efficiently harnessed. Despite an envisioned monetary saving, such a paradigm confines itself to limited application scenarios, which fails to reach a wide realm of roaming users outside the distance coverage of the access points. In this paper, we propose a cloudlet-based multi-lateral resource exchange framework for mobile users, relying on no central entities. Inspired by the success of BitCoin, we design a novel virtual currency tailored for our framework. To realize an efficient resource exchange market, we also introduce flexible pricing strategies adopted by the individual users whom we assume are rational price-takers, with solid theoretical analysis on the equilibrium state and the stability. After elaborating the key functional modules, we introduce a prototype design enabling seamless trading among mobile users on Internet bandwidth as a proof-of-concept, with least user intervention. Both simulations and experiments are conducted to verify the practicality and efficiency of our system.
A Comparative Evaluation of Measurement-Based Psychiatric Care Delivered via Specialized Telemental Health Platform Versus Treatment As Usual: A Retrospective Analysis (2022)

Background and objective A significant proportion of the adult population in the United States (US) live with some form of mental illness. The more prevalent conditions of depression and anxiety are typically managed in primary care settings rather than specialty care. The aim of this study was to determine the efficacy of a novel, measurement-driven psychiatric treatment platform delivered via an online telemental health platform as compared to treatment as usual (TAU). Methods The TAU dataset and the telemental health platform (Brightside) dataset were constructed based on the total populations of adult patients receiving care for depression from January 2018 through December 2020 (November 2018 through March 2021 for the Brightside group). Patients in both groups had a primary mental health diagnosis of depression and the presence of a positive screen for depression as measured by the Patient Health Questionnaire-9 (PHQ-9) upon initiation of treatment. HITLAB, an independent digital health verification and testing lab, conducted comparative analyses of the two groups using the Chi-square test of independence. Results Close to 80% of telemental health platform patients experienced a reduction of 5 or more points from their baseline PHQ-9 score as compared to 52% of TAU patients. The mean reduction in PHQ-9 score was slightly higher in the Brightside group (-11.5) versus the TAU group (-10.1). Chi-square tests of independence [x2 (1, n=6281) = 256.75, p≤0.001] for meaningful reduction and for remission [x2 (1, n=6281) = 105.50 p≤0.001] were highly significant. Conclusion The telemental health platform patients performed significantly better than those under psychiatric TAU in terms of reduction in symptoms of depression in adults.
A Role for Interaction of the RNA Polymerase Flap Domain with the σ Subunit in Promoter Recognition (2002)

In bacteria, promoter recognition depends on the RNA polymerase sigma subunit, which combines with the catalytically proficient RNA polymerase core to form the holoenzyme. The major class of bacterial promoters is defined by two conserved elements (the -10 and -35 elements, which are 10 and 35 nucleotides upstream of the initiation point, respectively) that are contacted by sigma in the holoenzyme. We show that recognition of promoters of this class depends on the "flexible flap" domain of the RNA polymerase beta subunit. The flap interacts with conserved region 4 of sigma and triggers a conformational change that moves region 4 into the correct position for interaction with the -35 element. Because the flexible flap is evolutionarily conserved, this domain may facilitate promoter recognition by specificity factors in eukaryotes as well.
Cell Wall Chemical Composition of Enterococcus faecalis in the Viable but Nonculturable State (2000)

The viable but nonculturable (VBNC) state is a survival mechanism adopted by many bacteria (including those of medical interest) when exposed to adverse environmental conditions. In this state bacteria lose the ability to grow in bacteriological media but maintain viability and pathogenicity and sometimes are able to revert to regular division upon restoration of normal growth conditions. The aim of this work was to analyze the biochemical composition of the cell wall of Enterococcus faecalis in the VBNC state in comparison with exponentially growing and stationary cells. VBNC enterococcal cells appeared as slightly elongated and were endowed with a wall more resistant to mechanical disruption than dividing cells. Analysis of the peptidoglycan chemical composition showed an increase in total cross-linking, which rose from 39% in growing cells to 48% in VBNC cells. This increase was detected in oligomers of a higher order than dimers, such as trimers (24% increase), tetramers (37% increase), pentamers (65% increase), and higher oligomers (95% increase). Changes were also observed in penicillin binding proteins (PBPs), the enzymes involved in the terminal stages of peptidoglycan assembly, with PBPs 5 and 1 being prevalent, and in autolytic enzymes, with a threefold increase in the activity of latent muramidase-1 in E. faecalis in the VBNC state. Accessory wall polymers such as teichoic acid and lipoteichoic acid proved unchanged and doubled in quantity, respectively, in VBNC cells in comparison to dividing cells. It is suggested that all these changes in the cell wall of VBNC enterococci are specific to this particular physiological state. This may provide indirect confirmation of the viability of these cells.
The specificity of human spermatozoa/zona pellucida interaction under hemizona assay conditions (1993)

The objective of this prospective study was to evaluate the specificity of human sperm/zona pellucida interaction under hemizona assay (HZA) conditions in experiments with gametes from the same and different species. Human, cynomolgus monkey and hamster oocytes were used after salt-storage. Oocytes were bisected into matching hemizonae by micromanipulation and used in the HZA. Semen was obtained from healthy men (donors) and male cynomolgus monkeys and prepared by wash and swim-up. Sperm binding to matching hemizonae was assessed (tight binding) after 4-h coincubation in the HZA in homologous and interspecies experiments. Acrosome reaction was evaluated in the sperm droplets using FITC-PSA and on the hemizonae using the T-6 monoclonal antibody. On human hemizonae, the number of tightly bound sperm for human and monkey were 93.2 +/- 15.8 and 3.9 +/- 1.3, respectively (P < 0.001). On monkey hemizonae, the number of tightly bound sperm for monkey and human were 126.0 +/- 34.8 and 2.8 +/- 1.6, (P = 0.02) respectively. On hamster hemizonae, there was negligible binding of human and monkey sperm. There was a significantly higher incidence of acrosome reacted sperm on the zona pellucida in homologous compared to heterologous experiments. These results demonstrate a high species-specificity of human gamete functions under HZA conditions, providing further support for the use of this bioassay in infertility and contraception testing.
Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense (1990)

DL-alpha-Difluoromethylornithine is an enzyme-activated inhibitor of ornithine decarboxylase and an antagonist of polyamine metabolism that has been successful in clinical trials against West African sleeping sickness caused by Trypanosoma brucei gambiense. Its potential for use against the more virulent East African form of the disease, caused by T. brucei rhodesiense, is not certain. We examined 14 East African clinical isolates from the Kenya Trypanosomiasis Research Institute strain bank plus 2 established isolates for susceptibility to DL-alpha-difluoromethylornithine and to standard trypanocides. Seven of 16 strains were partially or totally refractory to DL-alpha-difluoromethylornithine in our test system. Four strains were also refractory to arsenical drugs, and five were refractory to diamidines. The results indicate that other novel agents or combinations of established agents may be needed for chemotherapy of East African disease.
Beyond proof-of-compliance: security analysis in trust management (2005)

Trust management is a form of distributed access control that allows one principal to delegate some access decisions to other principals. While the use of delegation greatly enhances flexibility and scalability, it may also reduce the control that a principal has over the resources it owns. Security analysis asks whether safety, availability, and other properties can be maintained while delegating to partially trusted principals. We show that in contrast to the undecidability of classical Harrison--Ruzzo--Ullman safety properties, our primary security properties are decidable. In particular, most security properties we study are decidable in polynomial time. The computational complexity of containment analysis, the most complicated security property we study, varies according to the expressive power of the trust management language.
Absorption of CO{sub 2}, H{sub 2}, S, and NO using dry FGD wastes (1996)

Limestone-based sorbents are used extensively in utility boilers and tail-gas desulfurization units to remove sulfur oxides formed during the combustion of fossil fuels. Such units generate {approximately}20 million tons of flue-gas desulfurization (FGD) wastes in the U.S. annually, the bulk of which ({approximately}95%) are discarded in landfills or holding ponds. However, a significant portion of the Ca in these materials is not sulfated (remains as CaO or Ca(OH){sub 2}), particularly in units that generate dry wastes. When hydrated, such wastes exhibit a strong affinity to absorb acid gases at ambient temperature. This study represents a continuation of previously reported CO{sub 2}-absorption studies and includes more recent work on the absorption of H{sub 2}S and NO. Ten FGD-waste samples along with a control fly ash were examined. Absorption capacities, the role of available calcium and particle size, and mineralogic changes in the wastes following exposure are discussed.
Total Diet Comparison in Fishes by Spearman Rank Correlation Coefficients (1974)

The Spearman rank correlation and t-test were employed as a novel method for comparative analysis of total diets of three species of Killifish (Cyprinodontidae). The Calfornia killifish, Fundulus parvipinnis and mummichog, F. heteroclitus, of Nova Scotia have similar diets in similar but remotely separated habitats. In contrast two populations of F. heteroclitus inhabiting substantially different habitats have different diets. Two phylogenetically related sympatric species, F. heteroclitus and the banded killifish, F. diaphanus are shown to have differing diets. These results agree with the expected feeding performance of closely related species inhabiting the same trophic level sympatrically and allopatrically.
Orchestrating and sharing large multimodal data for transparent and reproducible research (2021)

Reproducibility is essential to open science, as there is limited relevance for findings that can not be reproduced by independent research groups, regardless of its validity. It is therefore crucial for scientists to describe their experiments in sufficient detail so they can be reproduced, scrutinized, challenged, and built upon. However, the intrinsic complexity and continuous growth of biomedical data makes it increasingly difficult to process, analyze, and share with the community in a FAIR (findable, accessible, interoperable, and reusable) manner. To overcome these issues, we created a cloud-based platform called ORCESTRA ( orcestra.ca ), which provides a flexible framework for the reproducible processing of multimodal biomedical data. It enables processing of clinical, genomic and perturbation profiles of cancer samples through automated processing pipelines that are user-customizable. ORCESTRA creates integrated and fully documented data objects with persistent identifiers (DOI) and manages multiple dataset versions, which can be shared for future studies.
Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin‐derived peptides (2009)

Ubiquitin-derived peptides are bactericidal in vitro and contribute to the mycobactericidal activity of the lysosome. To further define interactions of ubiquitin-derived peptides with mycobacteria, we screened for mutants with increased resistance to the bactericidal activity of the synthetic ubiquitin-derived peptide Ub2. The four Ub2-resistant Mycobacterium smegmatis mutants were also resistant to the bactericidal action of other antimicrobial peptides and macrophages. Two mutants were in the mspA gene encoding the main M. smegmatis porin. Using a translocation-deficient MspA point mutant, we showed that susceptibility of M. smegmatis to Ub2 was independent of MspA channel activity. Instead, the M. smegmatis Ub2-resistant mutants shared a common phenotype of decreased cell wall permeability compared with wild-type bacteria. Expression of mspA rendered Mycobacterium tuberculosis CDC1551 more susceptible both to ubiquitin-derived peptides in vitro and to lysosomal killing in macrophages. Finally, biochemical assays designed to assess membrane integrity indicated that Ub2 treatment impairs membrane function of M. smegmatis and M. tuberculosis cells. The M. smegmatis Ub2-resistant mutants were more resistant than wild-type M. smegmatis to this damage. We conclude that Ub2 targets mycobacterial membranes and that reduced membrane permeability provides mycobacteria intrinsic resistance against antimicrobial compounds including bactericidal ubiquitin-derived peptides.
Mitogen-activated Protein Kinase p38 Mediates Regulation of Chondrocyte Differentiation by Parathyroid Hormone (2001)

Parathyroid hormone (PTH) and its related peptide regulate endochondral ossification by inhibiting chondrocyte differentiation toward hypertrophy. However, the intracellular pathway for transducing PTH/PTH-related peptide signals in chondrocytes remains unclear. Here, we show that this pathway is mediated by mitogen-activated protein kinase (MAPK) p38. Incubation of hypertrophic chondrocytes with PTH (1-34) induces an inhibition of p38 kinase activity in a time- and dose-dependent manner. Inhibition of protein kinase C prevents PTH-induced p38 MAPK inhibition, whereas inhibition of protein kinase A has no effect. Thus, protein kinase C, but not protein kinase A, is required for the inhibition of p38 MAPK by PTH. Treatment of hypertrophic chondrocytes by PTH or by p38 MAPK inhibitor SB203580 up-regulates Bcl-2, suggesting that Bcl-2 lies downstream of p38 MAPK in the PTH signaling pathway. Inhibition of p38 MAPK in hypertrophic chondrocytes by either PTH, SB303580, or both together leads to a decrease of hypertrophic marker type X collagen mRNA and an increase of the expression of prehypertrophic marker cartilage matrix protein. Therefore, inhibition of p38 converts a hypertrophic cell phenotype to a prehypertrophic one, thereby preventing precocious chondrocyte hypertrophy. Taken together, these data suggest a major role for p38 MAPK in transmitting PTH signals to regulate chondrocyte differentiation.
Second group of LBC scholars begin classes in Valdosta (2011)

A second group of 15 Librarians Build Communities scholars have begun the MLIS program at Valdosta State University. The program focuses on building communities through public librarians. Additional scholarships are available for ongoing semesters.
Processo per la sintesi del modafinil (2005)

The invention relates to the synthesis of modafinil [Ph2CHS(O)CH2CONH2] by oxidn. of sulfide Ph2CHSCH2CONH2 using H2O2 and isonicotinic acid-diethylene glycol. Examples describe the synthesis of the sulfide from diphenylmethanol and thiourea and its S-oxidn
<title>Endoscopic inspection and measurement</title> (1993)

The design of a panoramic viewing system and its application to cavity inspection and measurement are discussed, along with the general properties of a special panoramic annular lens (PAL). Various examples are described, showing how the PAL can be used for simple inspection or for precision contouring of interior walls of cavities using techniques such as moire, holointerferometry, and Electronic Speckle Pattern Interferometry (ESPI).