gebhart/patrepeval huggingface dataset:
Maturation pathways of dendritic cells determine TAP1 and TAP2 levels and cross‐presenting function (2008)

Cross‐presentation of exogenous antigens in the HLA class I pathway is key to the antigen presenting function of mature tumor‐loaded dendritic cells (DC). Conditions of DC maturation have been shown to influence the ability of DCs to induce T cell effector functions. However, it remains unknown if different pathways of DC maturation are associated with modulation in the ability of DCs to cross‐present tumor‐associated antigens. We compared DC matured with three clinically relevant cytokine protocols: IL‐1β, TNF‐α, IL‐6 (DC‐0), DC‐0+PGE‐2, or IFN‐γ, IFN‐α, TNF‐α, and IL1‐β (DC‐1). We found that these DC vary in the ability to cross‐present tumor antigens to CTL, with DC‐1 protocol being significantly more effective than the other protocols. This level of TA cross presentation was correlated with the level of expression of the antigen processing machinery (APM) components, TAP1 and TAP2, and to a lesser extent, tapasin, indicating that these components could be used to standardize DC preparations for optimal function. However, upregulation of TAP1/2 was not sufficient to explain the strongest cross‐presentation ability induced by DC‐1 cells, since IFN‐γ did not generate DC as effective at cross‐presentation as the full DC‐1 cytokine cocktail. These data indicate that DC maturation pathways modulate APM component expression and that DC vary in the ability to cross‐present TA to HLA class I‐restricted CTL.
Some recent improvements in modeling of electromagnetic well-logging sensors via numerical mode-matching (2017)

The numerical mode-matching (NMM) technique is a very efficient method to solve the electromagnetic problem of logging-while-drilling (LWD) sensors for geophysical prospecting. In this paper we present recent trends that have improved the numerical efficiency of the traditional NMM. Two NMM formulations are discussed here, with focus on its main relevant upgrades compared to previous approaches. We present numerical results for two case scenarios that demonstrate the accuracy of these new proposals to modeling typical well-logging tools used for oil and gas exploration.
Genome Sequence of Aggregatibacter actinomycetemcomitans RHAA1, Isolated from a Rhesus Macaque, an Old World Primate (2012)

Aggregatibacter actinomycetemcomitans is implicated in localized aggressive periodontitis. We report the first genome sequence of an A. actinomycetemcomitans strain isolated from an Old World primate.
A volatile silicon–transition-metal compound (1965)

B. J. Aylett and J. M. Campbell, Chem. Commun. (London), 1965, 217 DOI: 10.1039/C19650000217
Retinal Vascular Patterns (1961)

In the first paper of this series we presented observations on normal retinal vascular patterns prepared by a new technique. 1 The retinal vessels and certain adherent structures were separated from the rest of the retina by trypsin digestion and gentle agitation. The isolated network of intercommunicating vessels was then available for study with a variety of stains, unobscured by surrounding tissue which has prevented visualization of the minute vessels and their cells heretofore. In the second paper of this series la we reported on the relation of the capillary plexuses to each other as determined by observing the human retinal vascular pattern in 3 dimensions. The present paper will concern the distinctive vascular patterns found in different age groups and in association with hypertension, absolute glaucoma, and injury to the retina. Subsequent papers of this series will probably be concerned with vascular changes resulting from diabetes and experimental lesions.
Diagnostic and Therapeutic Use of Sonography-Guided Iliopsoas Peritendinous Injections (2005)

Sonography-guided iliopsoas bursal/peritendinous injections are useful in determining the cause of hip pain. They can provide relief to most patients with iliopsoas tendinosis/bursitis after hip replacement. The results of injection alone are not as successful in cases of idiopathic iliopsoas tendinosis/bursitis, but the technique can help determine which patients may benefit from a surgical tendon release.
Structure of the neuroleptic drug N-[(1-allyl-2-pyrrolidinyl)methyl]-6-methoxy-1H-benzotriazole-5-carboxamide hydrochloride (alizapride) (1990)

C16H22NsO~-.CI -, Mr = 3515, monoclinic, P2~/c, a = 8.8439 (7), b = 16.6827 (9), c = 12.2196 (10)/~,/3 = 92.510 (6) °, V = 1801.2 (2)/~3, Z =4, Dm=129, Dx=1297Mgm-3, Ni-filtered Cu Ka radiation, a = 1-54178/~, /1, = 2.045 mm-~, F(000) = 744, T = 293 K. Final R = 0.052 for 2281 unique observed reflections. The benzamide moiety is planar. This planar conformation is stabilized by an intramolecular hydrogen bond which is typical for most o-methoxybenzamides. The folded conforma- tion of the pyrrolidine side chain is stabilized by an intramolecular hydrogen bond between H(14) and C1. Part of the pyrrolidine ring seems to be dis- ordered.
Gain Compression and Above-Threshold Linewidth Enhancement Factor in 1.3-$\mu\hbox{m}$ InAs–GaAs Quantum-Dot Lasers (2008)

Quantum-dot (QD) lasers exhibit many useful properties such as low threshold current, temperature and feedback insensitivity, chirpless behavior, and low linewidth enhancement factor (alpha <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</sub> -factor). Although many breakthroughs have been demonstrated, the maximum modulation bandwidth remains limited in QD devices, and a strong damping of the modulation response is usually observed pointing out the role of gain compression. This paper investigates the influence of the gain compression in a 1.3-mum InAs-GaAs QD laser and its consequences on the above-threshold alpha <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</sub> -factor. A model is used to explain the dependence of the alpha <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</sub> -factor with the injected current and is compared with AM/FM experiments. Finally, it is shown that the higher the maximum gain, the lower the effects of gain compression and the lower the alpha <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</sub> -factor. This analysis can be useful for designing chirpless QD lasers with improved modulation bandwidth as well as for isolator-free transmission under direct modulation.
Aluminum foil as anode material of lithium-ion batteries: Effect of electrolyte compositions on cycling parameters (2013)

Aluminum is used as an example to demonstrate the possibility of spatial stabilization of alloy-forming electrodes of lithium-ion batteries using target formation on their surface of a thin compact inorganic layer and elastic organopolymer coating of products of electroreduction of electrolyte components for improvement of capacity retention and suppression of processes corresponding to irreversible capacity. It is suggested to use aluminum foil as a convenient material and the general approach can be employed as a methodological technique for accelerated composition of an acceptable electrolyte formula for electrodes containing other elements forming alloys with lithium (in particular, silicon and tin).
ChemInform Abstract: The Use of Reaction Intermediates to Probe Supercritical Fluid Solvent Effects (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identifying the Primary Site Using Gene Expression Profiling in Patients with Carcinoma of an Unknown Primary (CUP): A Feasibility Study from the GEFCAPI (2012)

specimens from 18 of the 22 patients (82%). In the remaining 4 cases the test could not be performed because of low RNA preservation in the specimens. Results concerning the 18 patients are reported in the table 1, with 5 suggested tumor types according to the gene expression profile and final suggested diagnosis, integrating analysis of medical history, immunohistochemistry, and type of biopsy. The median age of the patients was 54 years (range: 29–70 years). The median delay from tissue shipping to receipt of CupPrint result was 11 days (range: 1–26 days). The most common tissues of origin identified were lung cancer (22%) and colorectal cancer (17%). Of note, primary cancers which would not be adequately treated by an empiric chemotherapy regimen currently recommended in CUP (such as cisplatin-gemcitabine or carboplatin-paclitaxel) was identified in about half of the patients: kidney cancer (1), hepatocarcinoma (1), colorectal cancer (3), head and neck cancer (2), cholangiocarcinoma (1) (table 1). At least two clinical cases suggested the potential implication of adjusting treatment according to the suggested primary. The first patient, a 50-year-old woman (patient 1, table 1), presented with a swollen left inguinal lymph node. The biopsy specimen revealed an undifferentiated carcinoma, ck7–, ck20–, RE–, PS100–, EMA– (07/2008). The CupPrint suggested the diagnosis of breast cancer, melanoma, or oral carcinoma. She underwent an inguinal dissection that showed a metastasis from melanoma (PS100 and vimentin positive). The dermatological examination revealed a lesion of the skin on the left knee. Surgical excision and histology confirmed the diagnosis of a superficial melanoma, SSM level 2, 0.44 mm deep. The patient is still in remission. The second case, a 63-year-old woman, presented with swollen left supra-clavicular, mediastinal and axillary lymph nodes (patient 2, table 1). The axillary lymph node dissection revealed an epidermoid carcinoma (ck7+, 20-). The CupPrint
Cumulants: A powerful tool in signal processing (1987)

The impulse response of a linear, time-invariant system is related in a simple closed-form solution to the output cumulants, when the input is assumed to be non-Gaussian and independent. This expression permits the use of one-dimensional processing of the output cumulants for identification of non-minimum-phase systems, and opens new directions in other signal processing applications.
Antagonism of Glyphosate Toxicity to Johnsongrass (Sorghum halepense) by 2,4-D and Dicamba (1989)

Greenhouse studies were conducted to determine the basis for reduced johnsongrass control when glyphosate was applied in mixtures with 2,4-D or dicamba. Glyphosate was applied to johnsongrass at 0.28, 0.56, 0.84, and 1.12 kg/ha alone and in combination with 2,4-D or dicamba at 0.14, 0.28, 0.14, or 0.56 kg/ha. Johnsongrass shoot and root fresh weights measured 4 weeks after treatment were higher when glyphosate was applied with 2,4-D (0.28 kg/ha glyphosate) or dicamba (0.28 kg/ha or 0.56 kg/ha glyphosate) compared to glyphosate applied alone at these rates. The antagonism of johnsongrass control was not observed with combinations of some of the higher glyphosate rates with 2,4-D (0.56 or 0.84 kg/ha glyphosate) or dicamba (0.84 or 1.12 kg/ha glyphosate). The reduction of glyphosate activity on johnsongrass occurred when any of four forms of 2,4-D or two forms of dicamba were added to the glyphosate spray mixture. Glyphosate uptake into johnsongrass leaves and subsequent translocation to the roots was reduced by the presence of 2,4-D or dicamba. The reduced glyphosate uptake and translocation could account for the decreased toxicity of glyphosate to johnsongrass when applied with 2,4-D or dicamba.
Polymorphism of B-tropic leukemia viruses from BALB/c mice: association of a p30 antigen with N- versus B-tropism (1979)

Comparison of a number of murine leukemia virus clones by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed extensive protein polymorphism among B-tropic, but not N-tropic, isolates from BALB/c mice, particularly in migration of p30 proteins. A type-specific radioimmunoassay for p30 was developed which uniformly discriminated all B-tropic viruses from N-tropic viruses of BALB/c origin. N- and B-tropic viruses of C57BL/6 and AKR Fv-1b/b origin could also be distinguished by this assay.
The Fanconi Anemia Group C Gene Product Is Located in Both the Nucleus and Cytoplasm of Human Cells (1998)

The Fanconi anemia (FA) complementation group C (FAC) protein gene encodes a cytoplasmic protein with a predicted Mr of 63,000. The protein's function is unknown, but it has been hypothesized that it either mediates resistance to DNA cross-linking agents or facilitates repair after exposure to such factors. The protein also plays a permissive role in the growth of colony-forming unit-granulocyte/macrophage (CFU-GM), burst-forming unit-erythroid (BFU-E), and CFU-erythroid (CFU-E). Attributing a specific function to this protein requires an understanding of its intracellular location. Recognizing that prior study has established the functional importance of its cytoplasmic location, we tested the hypothesis that FAC protein can also be found in the nucleus. Purified recombinant Escherichia coli-derived FAC antigens were used to create antisera able to specifically identify an Mr = 58,000 protein in lysates from human Epstein-Barr virus (EBV)-transformed cell lines by immunoblot analysis. Subcellular fractionation of the cell lysates followed by immunoblot analysis revealed that the majority of the FAC protein was cytoplasmic, as reported previously; however, approximately 10% of FAC protein was reproducibly detected in nuclear fractions. These results were reproducible by two different fractionation methods, and included markers to control for contamination of nuclear fractions by cytoplasmic proteins. Moreover, confocal image analysis of human 293 cells engineered to express FAC clearly demonstrated that FAC protein is located in both cytoplasmic and nuclear compartments, consistent with data obtained from fractionation of the FA cell lines. Finally, complementation of the FAC defect using retroviral-mediated gene transfer resulted in a substantial increase in nuclear FAC protein. Therefore, while cytoplasmic localization of this protein appears to be functionally important, it may also exert some essential nuclear function.
Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors (2015)

Mesenchymal stem/stromal cells (MSCs) represent a promising adult progenitor cell source for tissue repair and regeneration. Their mysterious identity in situ has gradually been unveiled by the accumulating evidence indicating an association between adult multipotent stem/progenitor cells and vascular/perivascular niches. Using immunohistochemistry and fluorescence-activated cell sorting, we and other groups have prospectively identified and purified subpopulations of multipotent precursor cells associated with the blood vessels within multiple human organs. The three precursor subsets, myogenic endothelial cells (MECs), pericytes (PCs), and adventitial cells (ACs), are located, respectively, in the three structural tiers of typical blood vessels: intima, media, and adventitia. MECs, PCs, and ACs have been extensively characterized in prior studies and are currently under investigation for their therapeutic potentials in preclinical animal models. In this review, we will briefly discuss the identification, isolation, and characterization of these human blood-vessel-derived stem cells (hBVSCs) and summarize the current status of regenerative applications of hBVSC subsets.
Application of a Macroporous Silica-Based CMPO-Impregnated Polymeric Composite in Group Partitioning of Long-Lived Minor Actinides from Highly Active Liquid by Extraction Chromatography (2008)

A macroporous silica-based octyl(phenyl)-N,N-diisobutylcarbamoylmethylphoshine oxide (CMPO) chelating polymeric composite, CMPO/SiO2−P, was synthesized by impregnating and immobilizing CMPO into the pores of SiO2−P particles support. To separate long-lived minor actinide (MA(III)) elements such as Am(III) and Cm(III) from highly active liquid waste (HLW), the adsorption and elution of 13 representative simulated fission products from a 3.0 M HNO3 were performed. It was carried out through two columns, both packed with CMPO/SiO2−P at 323 K. In the first column, all of the simulated elements were separated into three groups: (1) Cs(I), Sr(II), and a portion of Ru(III) (nonadsorption group); (2) Pd(II), a portion of Zr(IV), and all of REs(III) (MA-RE−Pd-Zr group); and (3) most of Zr(IV), Mo(VI), and a portion of Ru(III) (FPs group) by eluting with 3.0 M HNO3, H2O, and 0.5 M H2C2O4, respectively. MA(III) were predicted to flow into the second group along with Gd(III) because of their close adsorption and elution behaviors onto CMPO/SiO2−P. By addition of 0.5 M DTPA and conditioning of the HNO3 concentration to 3.0 M, the MA(III)-containing effluent was then supplied to the second column and separated into (1) Pd(II), (2) RE(III) elements Sm(III), Eu(III), Gd(III), and Y(III) (MA-RE group), and (3) Zr(IV) by eluting with 3.0 M HNO3, H2O, and 0.5 M H2C2O4, respectively. MA(III) flowed into the MA-RE group along with Gd(III). Based on the position of MA(III) in the elution curves, an effective group partitioning process of MA(III) and RE(III) from HLW by extraction chromatography was proposed.
스포츠 중계방송에서 VR을 활용한 가상광고 제작에 관한 연구 -생방송 야구 중계에서의 가상광고를 중심으로- (2013)

2010년 1월 가상광고가 국내에 허용되어지고, 2010년 3월 2010 세계여자피겨선수권 대회에 서 삼성전자의 ``하우젠``이 우리나라 최초의 가상 광고로 방송되어졌다. 가상광고는 컴퓨터 그래픽 가상현실 기술을 이용하여 제작?가공되어진 이미지 혹 은 영상을 가상광고 송출 시스템에 의하여 생방송 중계 사이에 자연스럽게 삽입하여 실제로 현장에 존재하는 것처럼 보이게 하는 것이다. 2002년 가상 광고 도입에 대한 공청회를 통하여 입법화 되어진 가상광고는 2010년 1월 19일 스포츠 경기에 한정 되어 실행 될 수 있도록 공식적으로 허용되어졌다. 각 방송사들은 정부시행령에 의한 사전준비를 하였으나, 가상광고 제작에 대한 경험의 전무함으로 개 발의 어려움을 겪고 있었다. 따라서, 이미 활발하 게활용되어지고 있는 외국의 사례를 분석하여 제 작을 벤치마킹하였고, 기술적 부분에 대한 많은 시행착오를 겪어야 했다. 현재 가상광고에 대한 마케팅적 연구 및 광고효과와 관련된 연구 논문들은 다 소 있으나, 구체적 사례에 의한 제작과 표현방법에 대한 논문은 미진하다고 볼 수 있다. 따라서, 방송 에서 송출되어졌던 가상광고의 제작과 표현의 방식 을 비교분석하고, 스포츠방송에서 송출되어졌던 가상광고의 제작과정과 가상광고 제작에 대한 효율적 인 방안과 문제점을 서술하고, 가상광고의 초기 발 전 시점에서 가상광고 제작자와 연구자들에게 도움 이 되고자 한다.
NCMP-03. ANATOMIC AND SURGICAL FACTORS PREDICT DEVELOPMENT OF LEPTOMENINGEAL DISEASE IN PATIENTS WITH METASTATIC MELANOMA (2021)

Abstract Leptomeningeal disease (LMD) is a devastating complication of systemic malignancy, portending a poor prognosis with an estimated median survival of 4-6 weeks if left untreated. Several reports have suggested surgical resection as a potential causative factor. Herein, we explore if surgical and anatomical factors are correlated with development of LMD in patients with melanoma brain metastases. METHODS: Patients treated at our institution between 1999-2019 for primary melanoma with brain metastasis were compiled into a database based on ICD9/10 coding. 1,079 patients with melanoma brain metastases and appropriate imaging were identified, and 834 patients with a minimum of 3 months’ follow up were included. Patients were dichotomized by development of LMD or lack thereof, and categorized into an overall cohort, and surgical and non-surgical cohorts. Anatomic factors and ventricular access during surgery were investigated as possible correlative factors for the development of LMD. RESULTS: In the overall cohort, female gender(p=0.033), presence of dural metastasis(p=0.018), presence of periventricular lesions(p&amp;lt; .001), presence of intraventricular lesions(p&amp;lt; .001), and ventricular access during surgery(p&amp;lt; .001) were significantly associated with LMD. Patients undergoing surgery, or those undergoing surgery without ventricular access, were not at higher risk of LMD. On multivariate analysis, female gender(p=.033), presence of periventricular lesions (p&amp;lt; .001), presence of intraventricular lesions(p&amp;lt; .002), and presence of dural metastasis(p=0.032) were significantly associated with development of LMD. In patients who had surgery, iatrogenic ventricular access(p&amp;lt; .001) was significantly correlated with LMD. In the group of patients without surgery, those with periventricular lesions had significantly higher odds of LMD(p&amp;lt; .001). CONCLUSIONS: In a retrospective cohort of patients with melanoma metastatic to the brain, surgical intervention does not increase odds of LMD; however, iatrogenic access to the CSF space during surgery is highly correlated with LMD development. Anatomic contact with the CSF space predicts LMD regardless of surgical status.
Numerical prediction of SDOF-Perforate Plate Acoustic Treatment Impedance. Part 1: Linear domain (2007)

A new numerical prediction tool has been developed in order to improve acoustics impedance predictions for typical Nacelle SDOF with perforated-plate liners, accounting for realistic geometry and flow. This method is based on domain breakdown and Linearized Compressible Navier-Stokes equations in the holes. Numerical Results are successfully compared to analytical predictions and measurements in the linear domain without flow. Next steps are non-linear effects and the influence of grazing mean flow.
Plasmon-Enhanced Photoluminescence of Silicon Quantum Dots:  Simulation and Experiment (2007)

The enhancement of photoluminescence emission from silicon quantum dots in the near field of cylindrical silver particles has been calculated using finite integration techniques. This computational method permitted a quantitative examination of the plasmon resonance frequencies and locally enhanced fields surrounding coupled arrays of silver particles having arbitrary shapes and finite sizes. We have studied Ag nanoparticles with diameters in the 50−300 nanometer range and array pitches in the range of 50−800 nm, near a plane of optical emitters spaced 10−40 nm from the arrays. The calculated and experimental plasmon resonance frequencies and luminescence enhancements are in good agreement. In the tens-of-nanometers size regime, for the geometries under investigation, two competing factors affect the photoluminescence enhancement; on one hand, larger field enhancements, which produce greater emission enhancements, exist around smaller silver particles. However, as the spacing of such particles is decreased to attain higher surface coverages, the interparticle coupling draws the enhanced field into the lateral gaps between particles and away from the emitters, leading to a decrease in the plasmonic emission enhancement. The computations have thus revealed the limitations of using arbitrarily dense arrays of plasmonic metal particles to enhance the emission from coplanar arrays of dipole-like emitters. For such a geometry, a maximum sixfold net emission enhancement is predicted for the situation in which the plasmonic layer is composed of 50 nm diameter Ag particles in an array having a 300 nm pitch.