gebhart/patrepeval huggingface dataset:
Fabrication of vertically standing metal nanowire arrays on silicon substrates using anodized aluminum oxide (AAO) and polycarbonate (PC) templates (2009)

We present a new fabrication method to grow vertically aligned nanowire arrays on a silicon substrate using commercially available anodized aluminum oxide (AAO) and polycarbonate (PC) templates. This technique eliminates the preparation procedure of coating one side of the template with a conductive layer, which is required in most template assisted nanowire growth methods. In this study, vertically aligned nanowires with a high aspect ratio of over 10 were fabricated on silicon substrate by electrodeposition, potentially enabling mass production.
A SNP‐based genetic dissection of versatile traits in bread wheat (Triticum aestivum L.) (2021)

The continuous increase in global population prompts increased wheat production. Future wheat (Triticum aestivum L.) breeding will heavily rely on dissecting molecular and genetic bases of wheat yield and related traits which is possible through the discovery of quantitative trait loci (QTLs) in constructed populations, such as recombinant inbred lines (RILs). Here, we present an evaluation of 92 RILs in a bi-parental RIL mapping population (the International Triticeae Mapping Initiative Mapping Population [ITMI/MP]) using newly generated phenotypic data in 3-year experiments (2015), older phenotypic data (1997-2009), and newly created single nucleotide polymorphism (SNP) marker data based on 92 of the original RILs to search for novel and stable QTLs. Our analyses of more than 15 unique traits observed in multiple experiments included analyses of 46 traits in three environments in the USA, 69 traits in eight environments in Germany, 149 traits in 10 environments in Russia, and 28 traits in four environments in India (292 traits in 25 environments) with 7584 SNPs (292 × 7584 = 2 214 528 data points). A total of 874 QTLs were detected with limit of detection (LOD) scores of 2.01-3.0 and 432 QTLs were detected with LOD > 3.0. Moreover, 769 QTLs could be assigned to 183 clusters based on the common markers and relative proximity of related QTLs, indicating gene-rich regions throughout the A, B, and D genomes of common wheat. This upgraded genotype-phenotype information of ITMI/MP can assist breeders and geneticists who can make crosses with suitable RILs to improve or investigate traits of interest.
Early morphological effects in word recognition in Hebrew: Evidence from parafoveal preview benefit (2000)

Hebrew words are composed of two interwoven morphemes: a triconsonantal root and a word pattern. Two experiments examined the effect of the root morpheme on word identification by assessing parafoveal preview benefit effects. Although the information of the preview was not consciously perceived, preview of the root's letters facilitated both naming and lexical decisions of target words derived from these roots. These results converge with previous results in Hebrew using the masked priming paradigm, suggesting that morphological units mediate early stages of word identification in Hebrew.
Reservoir computing model of prefrontal cortex creates novel combinations of previous navigation sequences from hippocampal place-cell replay with spatial reward propagation (2019)

As rats learn to search for multiple sources of food or water in a complex environment, they generate increasingly efficient trajectories between reward sites. Such spatial navigation capacity involves the replay of hippocampal place-cells during awake states, generating small sequences of spatially related place-cell activity that we call "snippets". These snippets occur primarily during sharp-wave-ripples (SWRs). Here we focus on the role of such replay events, as the animal is learning a traveling salesperson task (TSP) across multiple trials. We hypothesize that snippet replay generates synthetic data that can substantially expand and restructure the experience available and make learning more optimal. We developed a model of snippet generation that is modulated by reward, propagated in the forward and reverse directions. This implements a form of spatial credit assignment for reinforcement learning. We use a biologically motivated computational framework known as 'reservoir computing' to model prefrontal cortex (PFC) in sequence learning, in which large pools of prewired neural elements process information dynamically through reverberations. This PFC model consolidates snippets into larger spatial sequences that may be later recalled by subsets of the original sequences. Our simulation experiments provide neurophysiological explanations for two pertinent observations related to navigation. Reward modulation allows the system to reject non-optimal segments of experienced trajectories, and reverse replay allows the system to "learn" trajectories that it has not physically experienced, both of which significantly contribute to the TSP behavior.
Factors Affecting the Manufacturing Industry Transformation and Upgrading: A Case Study of Guangdong–Hong Kong–Macao Greater Bay Area (2021)

This study aims to analyze the development trend of the manufacturing industry transformation and upgrading in the Guangdong-Hong Kong-Macao Greater Bay Area (2008-2018). On the basis of synergetics, the order parameter method of factor analysis is used to study these factors. The results show that: (1) There are five slow variable factors, such as intelligent manufacturing industry, technological innovation, scale agglomeration, market demand, and fixed asset investment, which are important power sources of the transformation and upgrading of the manufacturing industry in Greater Bay Area. The development of these factors is relatively mature, and they cooperate with each other. (2) Similar to a fast variable of manufacturing development ecology, green development is an important coordinating factor in removing bottlenecks. Finally, suggestions for the development of the transformation and upgrading of the manufacturing industry are put forward.
Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior (2019)

Previous studies have shown that insulin and IGF-1 signaling in the brain, especially the hypothalamus, is important for regulation of systemic metabolism. Here, we develop mice in which we have specifically inactivated both insulin receptors (IRs) and IGF-1 receptors (IGF1Rs) in the hippocampus (Hippo-DKO) or central amygdala (CeA-DKO) by stereotaxic delivery of AAV-Cre into IR<sup>lox/lox</sup>/IGF1R<sup>lox/lox</sup> mice. Consequently, both Hippo-DKO and CeA-DKO mice have decreased levels of the GluA1 subunit of glutamate AMPA receptor and display increased anxiety-like behavior, impaired cognition, and metabolic abnormalities, including glucose intolerance. Hippo-DKO mice also display abnormal spatial learning and memory whereas CeA-DKO mice have impaired cold-induced thermogenesis. Thus, insulin/IGF-1 signaling has common roles in the hippocampus and central amygdala, affecting synaptic function, systemic glucose homeostasis, behavior, and cognition. In addition, in the hippocampus, insulin/IGF-1 signaling is important for spatial learning and memory whereas insulin/IGF-1 signaling in the central amygdala controls thermogenesis via regulation of neural circuits innervating interscapular brown adipose tissue.
Typical data models are inadequate for hypertemporal imagery (2015)

We highlight challenges associated with using conventional pattern recognition methods to test imagery from a persistent longwave infrared remote sensing experiment, where material surface emissivity and temperature among other factors dominate the apparent radiance observed at the sensor. We also propose a superior data model for the task.
Demonstration of a high resolution x-ray detector for medical imaging (2018)

In digital X-ray imaging, a crucial factor determining image resolution of all indirect detection systems is the spread of light in the X-ray scintillator. Currently deployed clinical x-ray detectors, with a resolution between 75 and 300 microns, are affected by such spread of light. This work demonstrates the significantly improved the resolution of an indirect X-ray scintillation detector using a new structuring approach The new structured scintillator consists of three main components: a high optical quality ‘channel plate’, a reflective material within the capillaries of the channel plate, and a polymer-based scintillating material that is incorporated in the capillaries. Channel plates, which are utilized for a variety of optical applications, are produced from bundles of hollow drawn borosilicate glass fibers, with repeated bundling and drawing reducing the diameter of the core and capillary pores down to values as low as 5 microns. These bundles are then cut to make high quality plates (‘channel plates’) with a thickness around 1 mm. Channel plates contain geometrically ordered capillary channels (about 5 million channels per square cm). The channel walls were coated with a 70 nm thick coating of Al<sub>2</sub>O<sub>3</sub>:W using atomic layer deposition (ALD) to optically confine the photoemission within the channel. The optical channel plates were infiltrated with a new bismuth-based scintillating polymer developed at Lawrence Livermore National Laboratory, with a photon yield of &gt; 30,600 photons/keV for X-ray energies of 20-30 keV, a range of interest for mammography. The new scintillator plate was used to experimentally demonstrate an X-ray resolution of 10 microns (or 50 linepairs/ mm), an approximately 7 times improvement over existing scintillating detectors. A structured scintillator plate, coupled with a digital detection system may be used to improve the spatial resolution in applications such as mammography, radiography, and computed tomography.
Bisphenol A activates BK channels through effects on α and β1 subunits (2014)

We demonstrated previously that BK (K(Ca)1.1) channel activity (NP(o)) increases in response to bisphenol A (BPA). Moreover, BK channels containing regulatory β1 subunits were more sensitive to the stimulatory effect of BPA. How BPA increases BK channel NPo remains mostly unknown. Estradiol activates BK channels by binding to an extracellular site, but neither the existence nor location of a BPA binding site has been demonstrated. We tested the hypothesis that an extracellular binding site is responsible for activation of BK channels by BPA. We synthesized membrane-impermeant BPA-monosulfate (BPA-MS) and used patch clamp electrophysiology to study channels composed of α or α + β1 subunits in cell-attached (C-A), whole-cell (W-C), and inside-out (I-O) patches. In C-A patches, bath application of BPA-MS (100 μM) had no effect on the NP(o) of BK channels, regardless of their subunit composition. Importantly, however, subsequent addition of membrane-permeant BPA (100 μM) increased the NP(o) of both α and α + β1 channels in C-A patches. The C-A data indicate that in order to alter BK channel NP(o), BPA must interact with the channel itself (or some closely associated partner) and diffusible messengers are not involved. In W-C patches, 100 μM BPA-MS activated current in cells expressingα subunits, whereas cells expressing α + β1 subunits responded similarly to a log-order lower concentration (10 μM). The W-C data suggest that an extracellular activation site exists, but do not eliminate the possibility that an intracellular site may also be present. In I-O patches, where the cytoplasmic face was exposed to the bath, BPA-MS had no effect on the NP(o) of BK α subunits, but BPA increased it. BPA-MS increased the NP(o) of α + β1 channels in I-O patches, but not as much as BPA. We conclude that BPA activates BK α via an extracellular site and that BPA-sensitivity is increased by the β1 subunit, which may also constitute part of an intracellular binding site.
Auswirkungen der langfristigen Landnutzungsdynamik auf die Ökosysteme Südost-Polens (2006)

Ziel dieser Arbeit ist es, die langfristigen Auswirkungen der Landnutzungsdynamik auf die Ökosysteme in Südost-Polen zu untersuchen. Die Untersuchungsgebiete liegen westlich von Lublin im Landschaftsschutzpark Kazimierz Dolny an der Vistula/Weichsel und südlich von Lublin im Roztocze Höhenrücken. Die durch Starkniederschläge ausgelöste und durch Landnutzung ermöglichte Bodenerosion hat in diesen Gebieten Topographie, Abflussgeschehen und Bodenfruchtbarkeit stark beeinflusst. Im Mittelpunkt dieser Arbeit steht die Bodenerosion durch Wasser, ausgelöst durch Abfluss auf der Bodenoberfläche nach erosiven Niederschlägen und Schneeschmelze. Um die räumlichen und zeitlichen Größenordnungen der Bodenerosion besser einschätzen zu können, wurden vor Ort mit der Methodik der vierdimensionalen Landschaftssystemanalyse drei Untersuchungsgebiete mit mehreren Meter mächtigen Kolluvien analysiert.
PCR‐RFLP and DAMD‐PCR genotyping for Salvia species (2008)

Abstract BACKGROUND: Identification of genotypes in Salvia is complicated owing to the morphological similarity and common occurrence of natural hybridisation within Salvia species. Species‐ and genotype‐specific DNA markers are very useful for plant identification, breeding and preservation programmes and can also provide a general overview on the prediction of plant essential oil yield. RESULTS: Polymerase chain reaction restriction fragment length polymorphism (PCR‐RFLP) was used for identification of species‐specific chloroplast and mitochondrial organelle DNA markers, and directed amplification of minisatellite DNA polymerase chain reaction (DAMD‐PCR) was used for genotyping of plant materials. Application of PCR‐RFLP resulted in species‐specific DNA markers, and use of DAMD‐PCR resulted in reproducible DNA patterns that are useful in Salvia genetic studies. Multivariate cluster analysis and principal coordinate analysis indicated that there were relationships between DNA marker patterns and essential oil yields at the species level. CONCLUSION: Results showed that genetic variations in Salvia are wide, and DNA patterns of relatedness among plant species appeared to correlate with essential oil yields. Further studies are required to confirm the application of PCR‐RFLP and DAMD‐PCR markers for selection of Salvia species with higher essential oil yield. Copyright © 2008 Society of Chemical Industry
Hardware-Accelerated Visual Hull Reconstruction and Rendering (2003)

Collision detection is a vital task in almost all forms of computer animation and physical simulation. It is also one of the most computationally expensive, and therefore a frequent impediment to efficient implementation of real-time graphics applications. We describe how graphics hardware can be used as a geometric co-processor to carry out the bulk of the computation involved with collision detection. Hardware frame buffer operations are used to implement a ray-casting algorithm which detects static interference between solid polyhedral objects. The algorithm is linear in both the number of objects and number of polygons in the models. It also requires no preprocessing or special data structures.
Tumor-derived indoleamine 2,3- dioxygenase regulates density of tumor infiltrating CD8+ T cells and myeloid derived suppressor cells in a murine model of ovarian cancer (2017)

Abstract The catabolism of the essential amino-acid tryptophan by indoleamine 2,3-dioxygenase (IDO1) is a central pathway that contributes to an immunosuppressive microenvironment in many types of cancer. Our lab has previously shown that IDO1 expression in human ovarian tumor correlates with poor prognosis and poor tumor infiltration by CD8+ T cells, and that improved survival is associated with increased tumor infiltrating lymphocytes. Thus, IDO1 inhibition represents an attractive target for cancer immunotherapy. To establish the mechanism by which IDO1 inhibition augments immune responses in a murine model of metastatic ovarian cancer, we generated a stable IDO1-overexpressing cell line (IE9mp1-mIDO1) and confirmed functional IDO1 enzyme activity. C57BL/6 mice were challenged intraperitoneally with IE9mp1-mIDO1 or IE9mp1-Empty Vector as a control. IE9mp1-mIDO1 tumor-bearing mice displayed earlier onset of tumor burden and decreased overall survival. To delineate the role of host- and tumor-derived IDO1 on immune cell infiltration in the tumor, IDO1 genetic knockout and C57BL/6 mice were challenged with IE9mp1-EV or -mIDO1 tumor cells. All mice challenged with IE9mp1-mIDO1 demonstrate decreased CD8+ T cells in the tumor compared to IDO1KO mice challenged with IE9mp1-EV tumor cells. Moreover, tumor-derived IDO1 mediates increased CD11b+Gr1+ myeloid derived suppressor cells (MDSC) in tumor ascites. From these data, we conclude that regulation of IDO1 will promote anti-tumor immune responses by permitting increased effector T cells in tumor tissues and decrease MDSCs in ascites. Ongoing experiments will characterize the mechanism by which IDO1 inhibition may augment vaccine-induced immune responses in ovarian cancer.
Seasonal Expression of INSL3 and Lgr8/Insl3 Receptor Transcripts Indicates Variable Differentiation of Leydig Cells in the Roe Deer Testis (2004)

Roe deer are seasonal breeders and show cyclic variation in testicular volume and cellular differentiation within the tubular and interstitial testis compartment. We have employed the roe deer as a model to elucidate the expression of the postpubertal Leydig cell marker INSL3 during seasonal changes in Leydig cell differentiation. Roe deer testis and serum samples were collected bimonthly throughout the complete reproductive cycle. Peak levels of testicular Insl3 mRNA and INSL3 immunoprotein were detected well before the onset of rut in April and coincided with the highest percentage of INSL3-positive cell number/square millimeter of testicular interstitial area. During the winter (December, February), roe deer INSL3 was exclusively detected in a subpopulation of alpha-actin-negative, spindle-shaped peritubular cells. Concordant with the increase in INSL3 production in April and 1 mo after the reported LH peak, a sharp increase in serum testosterone concentrations was observed. High serum testosterone concentrations coincided with the presence of detectable 17alpha-hydroxylase, mRNA and protein, in Leydig cells. Upregulation of INSL3 production in spring appeared to reflect LH-dependent differentiation of Leydig cells. The considerable changes in percentage of INSL3 immunopositive cells within the numerically constant interstitial cell population indicated cyclic seasonal de- and redifferentiation of Leydig cells. A complex functional role of the INSL3/LGR8 ligand-receptor system in the roe deer testis was suggested by the detection of specific hybridization signals for roe deer Lgr8 transcripts in Sertoli cells of the roe deer testis.
The Regiochemical Influence of Oxo-Substitution in Palladium-Mediated Hydrostannations of 1-Alkynes (2002)

A systematic study of hydroxyalkynes and their derivatives showed that the presence and position of the oxygen functionality can influence the regioselectivity of their Pd(0)-catalyzed and free radical hydrostannations. Regioselectivity is influenced by functional group proximity, sterics, and the nature of the substituent (hydroxyl, ether, or ester). Information provided herein may be useful when deciding which methodology and/or protective group strategy to employ when forming vinylstannanes.
Is the σ2 Receptor a Histone Binding Protein? (2006)

Starting from the high affinity sigma(2) receptor ligand 2, (PB28), we synthesized amino derivative 4 and coupled it to an NHS-ester activated sepharose stationary phase column to elute a crude protein prepared by lysed human SK-N-SH neuroblastoma cells. We characterized the SDS-PAGE gel electrophoresis stained bands by MALDI-MS and LC-MS-MS analysis. The MASCOT MS-MS ion search program led to the identification of the protein components. The six eluted proteins had a molecular weight ranging from 13 kDa to 26 kDa and were human histone proteins. A human 40S ribosomal protein S3 (SwissProt accession number: P23396) was also identified as a comigrated band. The human histone proteins that were characterized were H3.3A histone (NCBI accession number: 51859376), H2B histone (NCBI accession number: 1568557), H2A.5 histone (NCBI accession number: 70686), H1 (NCBI accession number: 22770677), and H2.1 histone (SwissProt accession number: P16403). These results disclosed a dual hypothesis about the sigma(2) receptor, that is, that it is formed by histones or that the sigma(2) ligands also bind histone proteins.
Performance evaluation of quantitative coronary angiography algorithms (2003)

There is a lack of an objective performance evaluation method for quantitative coronary angiography (QCA) algorithms. We present a novel approach to an accurate and objective performance evaluation. A simulation tool used to generate synthetic angiograms of a single coronary artery with a known centerline and diameter function is developed. It is used for an objective comparison of two QCA algorithms,.
Transparent Zeolite–Polymer Hybrid Materials with Adaptable Properties (2007)

Abstract We report here on a simple preparation procedure for highly transparent zeolite‐polymer hybrid materials and polymer covered zeolite L monolayers. Wrapping up zeolites containing, e.g., dye molecules as guest species with alkoxysilane derivatives results in an efficient dispersion of the nano particles into the organic liquid monomer. The following copolymerisation process leads to a hard, insoluble and transparent material containing zeolites. Optical properties such as colour, luminescence, refractive index or photochromism can be adapted by simply changing the type and amount of the guest in the zeolite crystals, while transparency is maintained.
ERRATA. 2-Amino-4-Methyl-6-Methoxymethylpyrimidine, Some Derivatives and Related Compounds. (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleERRATA. 2-Amino-4-Methyl-6-Methoxymethylpyrimidine, Some Derivatives and Related Compounds.Charles Price, Nelson Leonard, and David CurtainCite this: J. Org. Chem. 1946, 11, 6, 849Publication Date (Print):November 1, 1946Publication History Published online1 May 2002Published inissue 1 November 1946https://doi.org/10.1021/jo01176a027RIGHTS & PERMISSIONSArticle Views34Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (45 KB) Get e-Alerts Get e-Alerts