gebhart/patrepeval huggingface dataset:
Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles (2011)

Autophagy is a catabolic process that provides the degradation of altered/damaged organelles through the fusion between autophagosomes and lysosomes. Proper regulation of the autophagic flux is fundamental for the homeostasis of skeletal muscles in physiological conditions and in response to stress. Defective as well as excessive autophagy is detrimental for muscle health and has a pathogenic role in several forms of muscle diseases. Recently, we found that defective activation of the autophagic machinery plays a key role in the pathogenesis of muscular dystrophies linked to collagen VI. Impairment of the autophagic flux in collagen VI null (Col6a1–/–) mice causes accumulation of dysfunctional mitochondria and altered sarcoplasmic reticulum, leading to apoptosis and degeneration of muscle fibers. Here we show that physical exercise activates autophagy in skeletal muscles. Notably, physical training exacerbated the dystrophic phenotype of Col6a1–/– mice, where autophagy flux is compromised. Autophagy was not induced in Col6a1–/– muscles after either acute or prolonged exercise, and this led to a marked increase of muscle wasting and apoptosis. These findings indicate that proper activation of autophagy is important for muscle homeostasis during physical activity.
Deferred neural rendering (2019)

The modern computer graphics pipeline can synthesize images at remarkable visual quality; however, it requires well-defined, high-quality 3D content as input. In this work, we explore the use of imperfect 3D content, for instance, obtained from photo-metric reconstructions with noisy and incomplete surface geometry, while still aiming to produce photo-realistic (re-)renderings. To address this challenging problem, we introduce Deferred Neural Rendering , a new paradigm for image synthesis that combines the traditional graphics pipeline with learnable components. Specifically, we propose Neural Textures , which are learned feature maps that are trained as part of the scene capture process. Similar to traditional textures, neural textures are stored as maps on top of 3D mesh proxies; however, the high-dimensional feature maps contain significantly more information, which can be interpreted by our new deferred neural rendering pipeline. Both neural textures and deferred neural renderer are trained end-to-end, enabling us to synthesize photo-realistic images even when the original 3D content was imperfect. In contrast to traditional, black-box 2D generative neural networks, our 3D representation gives us explicit control over the generated output, and allows for a wide range of application domains. For instance, we can synthesize temporally-consistent video re-renderings of recorded 3D scenes as our representation is inherently embedded in 3D space. This way, neural textures can be utilized to coherently re-render or manipulate existing video content in both static and dynamic environments at real-time rates. We show the effectiveness of our approach in several experiments on novel view synthesis, scene editing, and facial reenactment, and compare to state-of-the-art approaches that leverage the standard graphics pipeline as well as conventional generative neural networks.
Synthesis, Structure, and Coordination Chemistry of the Bicyclic π-Acid Phosphatri(3-methylindolyl)methane (2000)

Reaction of tri(3-methylindolyl)methane (1) with PCl3 in the presence of triethylamine produces the bicyclic π-acid phosphatri(3-methylindolyl)methane (2). The unconstrained analogue tri(N-3-methylindolyl)phosphine (3) was synthesized by reaction of lithium 3-methylindolide with PCl3. Both 2 and 3 are stable to hydrolysis, alcoholysis, and aerial oxidation. Reactions of 2 with tBuOOH, S8, or Se powder under forcing conditions produce the chalcogenide derivatives 2O (4), 2S (5), and 2Se (6), respectively. Tri(N-3-methylindolyl)phosphine selenide (7) and SeP(N-pyrrolyl)3 (8) were synthesized by reaction of Se powder with 3 and P(N-pyrrolyl)3, respectively. The reaction of 2 with Rh(acac)(CO)2 (acac = acetylacetonate) under forcing conditions yields Rh(acac)(CO)(2) (9), whereas Rh(acac)(CO)(3) (10) was synthesized by reaction of 3 with Rh(acac)(CO)2 under mild conditions. Spectroscopic data for 6−10 were used to assess the electronic properties of 2 and 3. Reduced σ-basicity of 2 and 3 is indicated by lack of their reactivity with methyl iodide. Furthermore, comparison of the 1JP-Se values of 6−8 shows the parent phosphines to be slightly stronger σ-bases than P(OPh)3, but much weaker than triaminophosphines. In addition, comparison of the νCO data of 9 and 10 with those of known Rh(acac)(CO)(PR3) complexes shows 2 is a stronger π-acid than P(N-pyrrolyl)3 and P(OPh)3, while 3 has π-acceptor properties similar to P(OPh)3. The molecular structures of compounds 2, 4, and 9 were determined by X-ray crystallography.
Synthesis and Properties of Ethylenethiotetra- selenafulvalene (ET-TSF) and Its Conductive Radical Cation Salts (2006)

The title heterocycle-fused tetraselenafulvalene derivative, ET-TSF (ethylenethiotetraselenafulvalene) has been synthesized as a novel electron donor.Electrocrystallization of ET-TSF gave highly conductive radical cation salts with I 3 -, Cl -, Br -, and AuI 2 -counter anions.Among them, the AuI 2 salt isostructural with the organic superconductor (MDT-TSF)-AuI 2 (MDT-TSF = methylenedithiotetraselenafulvalene) was highly conductive (1600 S cm -1 ) and metallic down to 1.8 K with no superconducting transition.
More than a decade of real-world experience of pegvisomant for acromegaly: ACROSTUDY (2021)

This comprehensive review of the complete cohort in ACROSTUDY confirmed the overall favourable benefit-to-risk profile and high efficacy of PEGV as mono- and combination therapy in patients with an aggressive course/uncontrolled/active acromegaly requiring long-term medical therapy for control.
B cell lineage progression and identity are impeded synergistically in EBF1 and Runx1 haploinsuficient mice (36.13) (2010)

Abstract The transcription factors Early B cell factor 1 (EBF1) and Runx1 are essential for B cell development. B lymphopoiesis is arrested at an early state and hematopoiesis is ablated in the absence of EBF1 and Runx1, respectively. Previously, we demonstrated synergistic activity of EBF1 and Runx1 in the activation of the B cell-specific gene mb-1(Cd79a). To identify cooperative functions of these factors in vivo, we generated Ebf(Ehet)Runx(Rhet)-double haploinsufficient(ERhet ) mice. Significant compound effects were observed in ERhet mice. B cell numbers in the bone marrow and spleen were reduced greatly. Generation of pre-B and immature B cells in ERhet mice is impeded by: 1) reduced frequencies of Ig light chain gene rearrangements and 2) significant alterations in B cell-specific gene expression. Notably, repression of c-kit and activation of Aiolos were delayed. Interestingly, a high percentage of pro- and pre-B cells from ERhet mice expressed the NK cell markers NK1.1, CD160 and 2B4. Co-expressions of these NK cell markers with genes indicative of B cell commitment was demonstrated using multiplex, single cell PCR. Retroviral complimentation of Ebf1 and Runx1 deficiencies eliminated the promiscuous expression of NK cell genes in ERhet pro-B cells. Thus, appropriate dosage of Ebf1 and Runx1 is necessary for efficient activation of the B cell-specific program and suppression of lineage inappropriate genes. Our data solidify EBF1’s role in controlling B cell lineage commitment.
Electron Microscopic Cytochemical Demonstration of Heterogeneity of Mitochondria with Respect to the Activity of Different Oxidoreductases (1974)

Ultrahistochemical methods have only occasionally been used to demonstrate a heterogeneity of intracellular mitochondria. Methods have recently become available, however, for the direct demonstration of oxidoreductases such aa cytochrome oxidase (CYO), lactate dehydrogenase (LDH) and NADH dehydrogenase (NADHDH), in formalin-fixed tissues. By assessment of oxidoreductase activity at different parts of the electron transport system, an indication of the relative metabolic competence of mitochondria may be obtained.
An Efficient Dye‐Sensitized Solar Cell with an Organic Sensitizer Encapsulated in a Cyclodextrin Cavity (2009)

Dying to get inside: Charge recombination is retarded and dye aggregation is prevented in solar cells that contain the JK-2 dye encapsulated in a cyclodextrin (CD) cavity (see picture). The β-CD/JK-2 device with a polymer gel electrolyte gave an overall conversion efficiency of 7.40 %, which is the highest value reported to date for DSSCs based on the organic sensitizers, and showed excellent stability. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Application of smart-pixel and microlens arrays to early vision (2002)

We are developing smart sensors that perform retina-like functions in the analog optical domain using optically cascaded smart-pixel arrays. By performing operations such as center-surround or oriented edge detection in a fully parallel fashion before the image is digitized and passed on to a computer, such smart sensors can greatly reduce the computational overhead associated with preprocessing. In order to implement the smart-pixel arrays, we have developed and demonstrated a device known as the monolithic optoelectronic transistor (MOET). In this paper we discuss the advantages of the proposed implementation, such as compactness, manufacturability, and broad spectral coverage, over approaches involving diffractive optical elements. We also discuss the fabrication and performance of the MOET and the mass transported lenslet arrays.
Additional file 1: of Active recombinant Tol2 transposase for gene transfer and gene discovery applications (2016)

Estimation of transposon insertion numbers by Southern analysis. Individual GFP-positive F1 fish from random selected F0 founder families were fin-clipped for gDNA isolation. Southern blotting with a GFP probe was conducted for each fish gDNA and the number of clear-labeled Southern bands was recorded as estimation of transposon insertions. Total number of unique Southern bands was used to estimate total transposon insertions for each F0 founder family. An average insertion number over all the families analyzed was calculated for both injection methods. (DOCX 91Â kb)
Comments on "Data Mining Static Code Attributes to Learn Defect Predictors" (2007)

In this correspondence, we point out a discrepancy in a recent paper, "data mining static code attributes to learn defect predictors," that was published in this journal. Because of the small percentage of defective modules, using probability of detection (pd) and probability of false alarm (pf) as accuracy measures may lead to impractical prediction models.
Good News for Gene Therapy (2004)

The promise of gene therapy has been dimmed in the past few years by a number of setbacks, including the development of T-cell leukemia in infants treated for severe combined immunodeficiency. A recent study suggests that these cases do not augur ill for the field as a whole and that specific changes to gene-therapy protocols may reduce the chances that such therapy will inadvertently trigger cancer.
Novel insb-based quantum well transistors for ultra-high speed, low power logic applications (2005)

InSb-based quantum well field-effect transistors, with gate length down to 0.2 /spl mu/m, are fabricated for the first time. Hall measurements show that room temperature electron mobilities over 30,000 cm /sup 2/V/sup -1/s/sup -1/ are achieved with a sheet carrier density over 1/spl times/10/sup 12/ cm/sup -2/ in a modulation doped InSb quantum well with Al/sub x/In/sub 1-x/Sb barrier layers. Devices with 0.2 /spl mu/m gate length and 20% Al barrier exhibit DC transconductance of 625 /spl mu/S//spl mu/m and f/sub T/ of 150 GHz at V/sub DS/ =0.5V. 0.2 /spl mu/m devices fabricated on 30% Al barrier material show DC transconductance of 920 /spl mu/S//spl mu/m at V/sub DS/ = 0.5 V. Benchmarking against state-of-the-art Si MOSFETs indicates that InSb QW transistors can achieve equivalent high speed performance with 5-10 times lower dynamic power dissipation and therefore are a promising device technology to complement scaled silicon-based devices for very low power, ultra-high speed logic applications.
Dose-reduced fludarabine, cyclophosphamide and rituximab is well tolerated in older patients with chronic lymphocytic leukemia and has preserved therapeutic efficacy (2015)

Despite its efficacy in prospective trials, full dose fludarabine, cyclophosphamide and rituximab (FCR) may be too toxic for elderly patients with chronic lymphocytic leukemia (CLL) in clinical practice. We retrospectively reviewed the impact of dose reductions in FCR therapy on the outcomes of 42 consecutive patients aged 65-87 (median 72) years. Despite a median cumulative fludarabine dose reduction of 50% from full dose, the objective response and complete response rates were 86% and 38% respectively (frontline 94%/59%; previously treated 80%/24%). Dose reductions of 25-75% were not significantly associated with inferior progression free survival compared to minimal reductions (≤25%) (p=0.49), and did not preclude deep responses, including six cases (14%) of minimal residual disease negativity. Although hematological and infectious toxicities were common, treatment limiting adverse effects were infrequent. Dose attenuated FCR appears to have preserved efficacy and may be a viable therapeutic option for elderly patients with CLL.
228-Spatial-Channel Bi-Directional Data Communication System Enabled by 39-Core 3-Mode Fiber (2019)

We demonstrated simultaneous usage of 228 spatial channels (effectively) within a strand of fiber. We fabricated a 13-km 39-core 3-mode fiber and constructed a bi-directional space division multiplexing (SDM) transmission setup by using cascaded spatial multiplexers on both fiber ends. Aggregated intercore crosstalk and return loss of the system were below -35 and above 31 dB, respectively, over the C and L bands. The feasibility of using bi-directional SDM transmission was investigated using 10 GBaud, 37.38-Gb/s dual-polarization QPSK signals at 1550 nm and coherent detection with a 6 × 6 multi-input-multi-output equalizer. Excellent transmission properties were obtained for most spatial channels.
Arterial blood pressure analysis based on scattering transform I (2007)

This article presents a new method for analyzing arterial blood pressure waves. The technique is based on the scattering transform and consists in solving the spectral problem associated to a one-dimensional Schrödinger operator with a potential depending linearly upon the pressure. This potential is then expressed with the discrete spectrum which includes negative eigenvalues and corresponds to the interacting components of an N-soliton. The approach is analogous to the Fourier transform where the solitons play the role of sinus and cosinus components. The proposed method seems to have interesting clinical applications. It can be used for example to separate the fast and slow parts of the blood pressure that correspond to the systolic (pulse transit time) and diastolic phases (low velocity flow) respectively.
Diarylbibenzofuranone-Based Dynamic Covalent Polymer Gels Prepared via Radical Polymerization and Subsequent Polymer Reaction (2015)

Diarylbibenzofuranone (DABBF) is a dynamic covalent bonding unit, which is in equilibrium with the corresponding radicals at room temperature, and polymers with DABBF linkages show notable properties such as self-healing. The preparation routes have been strictly limited, however, and no polymer with the linkages has been synthesized via radical polymerization because of the strong antioxidant activity of DABBF. Here we present a new method to prepare DABBF-containing polymers via radical polymerization of the precursor, arylbenzofuranone (ABF), and subsequent polymer reaction, dimerization of ABF units in the linear polymers. Polymer gels cross-linked by DABBF linkages were obtained against the relatively strong antioxidant activity of ABF and showed dynamic network reorganization at room temperature.
Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere. (2001)

Abstract For Abstract see ChemInform Abstract in Full Text.
ChemInform Abstract: EFFECT OF THE PHASE TRANSFORMATION ON THE FRACTURE BEHAVIOR OF BARIUM TITANATE(IV) (1978)

Abstract Die Bruchzähigkeit von ein‐ und polykristallinem BaTiO 3 wird oberhalb und unterhalb der ferroelektrischen Curie‐Temp.
Thymidine phosphorylase expression in normal and hyperplastic endometrium: Figure 1 (2000)

TP is expressed consistently in normal and hyperplastic endometrium, suggesting a role in physiological and pathological angiogenesis. In normal endometrium, TP has a definite pattern of distribution, which is dependent on the phase of the menstrual cycle, whereas in all forms of endometrial hyperplasia the enzyme is randomly distributed and lacks an orderly pattern.
Influence of pulsed-arc welding conditions on change of parameters of weld and haz of welded joints and mechanical properties of low-alloy steels (2020)

The Paton Welding Journal, 2020, №12. International Scientific-Technical and Production Journal «The Paton Welding Journal» «The Paton Welding Journal» has been published monthly since 2000 in English, ISSN 0957-798X. «The Paton Welding Journal» is a cover-to-cover English translation of the «Avtomaticheskaya Svarka» (Automatic Welding) journal. The «Avtomaticheskaya Svarka» journal has been published monthly since 1948 in Russian, ISSN 005-111X.
Stacked Convolutional Bidirectional LSTM Recurrent Neural Network for Bearing Anomaly Detection in Rotating Machinery Diagnostics (2018)

This paper proposes a multi-layered anomaly detection scheme to train feature extraction and to test anomaly prediction by using Convolutional Neural Networks (CNNs) layer, Bidirectional and Unidirectional Long Short-Term Memory (LSTM) Recurrent Neural Networks (RNNs), which is one of a novel deep architecture named stacked convolutional bidirectional LSTM network (SCB-LSTM). In the proposed model, the stacked CNNs perform feature extraction of vibration sensor signal patterns, and the result is used to feature learning with the stacked bidirectional LSTMs (SB-LSTMs). After this procedure, the stacked unidirectional LSTMs (SU-LSTMs) enhance the feature learning, and a regression layer finally predicts anomaly detections. The experimental results of bearing data not only show the accuracy of the proposed model in anomaly detection for rotating machinery diagnostics, but also suggest the better performance than other state-of-the-art algorithms such as a plain uni-LSTM or Bi-LSTM.
Unraveling the 13C NMR Chemical Shifts in Single-Walled Carbon Nanotubes: Dependence on Diameter and Electronic Structure (2012)

The atomic specificity afforded by nuclear magnetic resonance (NMR) spectroscopy could enable detailed mechanistic information about single-walled carbon nanotube (SWCNT) functionalization as well as the noncovalent molecular interactions that dictate ground-state charge transfer and separation by electronic structure and diameter. However, to date, the polydispersity present in as-synthesized SWCNT populations has obscured the dependence of the SWCNT (13)C chemical shift on intrinsic parameters such as diameter and electronic structure, meaning that no information is gleaned for specific SWCNTs with unique chiral indices. In this article, we utilize a combination of (13)C labeling and density gradient ultracentrifugation (DGU) to produce an array of (13)C-labeled SWCNT populations with varying diameter, electronic structure, and chiral angle. We find that the SWCNT isotropic (13)C chemical shift decreases systematically with increasing diameter for semiconducting SWCNTs, in agreement with recent theoretical predictions that have heretofore gone unaddressed. Furthermore, we find that the (13)C chemical shifts for small diameter metallic and semiconducting SWCNTs differ significantly, and that the full-width of the isotropic peak for metallic SWCNTs is much larger than that of semiconducting nanotubes, irrespective of diameter.
GRANOGRAPHICAL LIFE RECORD CURVE METHOD FOR IDENTIFYING EACH STOCK OF PELAGIC FISHES-III (1963)

In this part of his granographical studies, the author tries on the basis of the data published in References 1 and 2 (see the corresponding column below) to answer the unsettled problem as to whether sardine yearlings having formed summer rings can of cannot further form winter rings within the year. In Table 1 and Fig. 1 are illustrated the data as the distinctiveness between the summer ring and the winter ring. While the first peak on life record curve draun for Stock D or E relates to the summer ring, other peaks correspond all to winter rings (see Fig. 3). From the known conformity of the time of spawning to that of scale-ring formation, it follows that these winter rings represent the annual rings proper. It was thus confirmed the possibility of that yearling sardine of some stock forms both summer ring and winter one. As to the embodiment of said possibility, however, the growth is not alone the determining factor. Referring to life record curve, it seems likely that each winter ring is produced as a configuration accompanied by e secondary ring to be formed contiguously to the former. The relation discovered between the age and growth is illustrated in Table 2 and Fig. 2.
2-Amino-3-(Oxirane-2,3-Dicarboxamido)-Propanoyl-Valine, an Effective Peptide Antibiotic from the Epiphyte Pantoea agglomerans 48b/90 (2009)

The epiphyte Pantoea agglomerans 48b/90, which has been isolated from soybean leaves, belongs to the Enterobacteriaceae, as does the plant pathogen Erwinia amylovora, which causes fire blight on rosaceous plants such as apples and leads to severe economic losses. Since P. agglomerans efficiently antagonizes phytopathogenic bacteria, the P. agglomerans strain C9-1 is used as a biocontrol agent (BlightBan C9-1). Here we describe the bioassay-guided isolation of a peptide antibiotic that is highly active against the plant pathogen E. amylovora and pathovars of Pseudomonas syringae, and we elucidate its structure. Bioassay-guided fractionation using anion-exchange chromatography followed by hydrophobic interaction liquid chromatography yielded the bioactive, highly polar antibiotic. The compound was identified as 2-amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine by using high-resolution electrospray ionization mass spectrometry and nuclear magnetic resonance techniques. This peptide was found to be produced by three of the nine P. agglomerans strains analyzed. Notably, the biocontrol strain P. agglomerans C9-1 also produces 2-amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine. Previously, 2-amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine has been characterized only from Serratia plymuthica. 2-Amino-3-(oxirane-2,3-dicarboxamido)-propanoyl-valine has been shown to inhibit the growth of the human pathogen Candida albicans efficiently, but its involvement in the defense of epiphytes against phytopathogenic bacteria has not been investigated so far.