gebhart/patrepeval huggingface dataset:
A PERIODIC REACTION IN HOMOGENEOUS SOLUTION AND ITS RELATION TO CATALYSIS. (1921)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA PERIODIC REACTION IN HOMOGENEOUS SOLUTION AND ITS RELATION TO CATALYSIS.William C. BrayCite this: J. Am. Chem. Soc. 1921, 43, 6, 1262–1267Publication Date (Print):June 1, 1921Publication History Published online1 May 2002Published inissue 1 June 1921https://pubs.acs.org/doi/10.1021/ja01439a007https://doi.org/10.1021/ja01439a007research-articleACS PublicationsRequest reuse permissionsArticle Views1794Altmetric-Citations381LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figure 8 from The Splicing Factor PTBP1 Represses <i>TP63 γ</i> Isoform Production in Squamous Cell Carcinoma (2023)

&lt;p&gt;endogenous TP63 regulation is unaffected in HaCaT cell lines expressing minigenes&lt;/p&gt;
Data from Inhibition of Wee1, AKT, and CDK4 Underlies the Efficacy of the HSP90 Inhibitor XL888 in an <i>In Vivo</i> Model of <i>NRAS</i>-Mutant Melanoma (2023)

&lt;div&gt;Abstract&lt;p&gt;The HSP90 inhibitor XL888 is effective at reversing BRAF inhibitor resistance in melanoma, including that mediated through acquired &lt;i&gt;NRAS&lt;/i&gt; mutations. The present study has investigated the mechanism of action of XL888 in &lt;i&gt;NRAS&lt;/i&gt;-mutant melanoma. Treatment of &lt;i&gt;NRAS&lt;/i&gt;-mutant melanoma cell lines with XL888 led to an inhibition of growth, G&lt;sub&gt;2&lt;/sub&gt;–M phase cell-cycle arrest, and the inhibition of cell survival in three-dimensional spheroid and colony formation assays. &lt;i&gt;In vitro&lt;/i&gt;, HSP90 inhibition led to the degradation of ARAF, CRAF, Wee1, Chk1, and cdc2 and was associated with decreased mitogen-activated protein kinase (MAPK), AKT, mTOR, and &lt;i&gt;c&lt;/i&gt;-jun NH&lt;sub&gt;2&lt;/sub&gt; kinase (JNK) signaling. Apoptosis induction was associated with increased BIM expression and a decrease in the expression of the prosurvival protein Mcl-1. The critical role of increased BIM and decreased Mcl-1 expression in the survival of &lt;i&gt;NRAS&lt;/i&gt;-mutant melanoma cell lines was shown through siRNA knockdown and overexpression studies. In an animal xenograft model of &lt;i&gt;NRAS&lt;/i&gt;-mutant melanoma, XL888 treatment led to reduced tumor growth and apoptosis induction. Important differences in the pattern of client degradation were noted between the &lt;i&gt;in vivo&lt;/i&gt; and &lt;i&gt;in vitro&lt;/i&gt; studies. &lt;i&gt;In vivo&lt;/i&gt;, XL888 treatment led to degradation of CDK4 and Wee1 and the inhibition of AKT/S6 signaling with little or no effect observed upon ARAF, CRAF, or MAPK. Blockade of Wee1, using either siRNA knockdown or the inhibitor MK1775, was associated with significant levels of growth inhibition and apoptosis induction. Together, these studies have identified Wee1 as a key target of XL888, suggesting novel therapeutic strategies for &lt;i&gt;NRAS-&lt;/i&gt;mutant melanoma. &lt;i&gt;Mol Cancer Ther; 12(6); 901–12. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Skin Depth of Electromagnetic Waves in Plasma with Magnetic Field and Collisions (1996)

Skin depth δ and wave number of various electromagnetic waves in plasma in which collisions occur have been analyzed without and with the magnetic field: right (R)- and left (L)- hand circularly polarized, ordinary (O) and extraordinary (X) waves. For most evanescent waves, δ is expressed as fc / ω pe for ω pe ≫ω, ν (f: collision term, ν : collision frequency, c : velocity of light, ω pe : electron plasma angular frequency). For L and X waves under limited conditions, δ is c / ω pe multiplied by (ω ce / ω)0.5 and ω ce / ω pe, respectively (ω ce: electron cyclotron angular frequency). In the low ν range with ω≈ω pe, δ becomes large for light, O, R and X waves (ω≫ω ce).
Microsystems, Space Qualified Electronics and Mobile Sensor Platforms for Harsh Environment Applications and Planetary Exploration (2007)

NASA Glenn Research Center is presently developing and applying a range of sensor and electronic technologies that can enable future planetary missions. These include space qualified instruments and electronics, high temperature sensors for Venus missions, mobile sensor platforms, and Microsystems for detection of a range of chemical species and particulates. A discussion of each technology area and its level of maturity is given. It is concluded that there is a strong need for low power devices which can be mobile and provide substantial characterization of the planetary environment where and when needed. While a given mission will require tailoring of the technology for the application, basic tools which can enable new planetary missions are being developed.
Interaction mechanism of carbon clusters and dislocation through molecular dynamics simulation (2018)

When a steel undergoes a heat treatment, the maximum strength appears in the middle of transition of carbon-atom states from the solid solution to the precipitation states. Recently, the latest observation technic has revealed the carbon cluster state where the steel shows the maximum strength. However, the strengthening mechanism by the carbon cluster has not been fully understood yet. In this study, to investigate the interaction mechanism between dislocation and carbon clusters, we perform molecular dynamics simulations. We show the strongest carbon cluster's diameter, which well corresponds to the experimental value, and propose strengthening mechanisms for each carbon cluster with different diameters.
Crystal Rotations under Conditions of Imposed Strain and the Influence of Twinning and Cross-Slip (1968)

Slip rotations in cubic crystals under conditions of imposed strain are not, in general, uniquely determined, since several equivalent sets of slip systems are available to produce the particular shape change. However, it is shown that for certain crystal orientations undergoing deformation by rolling only four systems are required to operate and in these cases the slip rotations are determined unambiguously. Two orientation ranges, those having 〈110〉 and 〈111〉 transverse directions, are considered and the rate of crystal rotation determined as a function of orientation. It is shown that orientations of the types {1110}〈112〉, {110}〈001〉, and near-{4,4,11}〈11,11,8〉 are stable for f.c.c. crystals and {112}〈110〉, {001}〈110〉, and near-{11,11,8}〈4,4,11〉 for b.c.c. crystals. The predictions of this limited analysis allow the various mechanistic theories of rolling texture formation in f.c.c. metals to be assessed. It is concluded that both twinning and cross-slip are required to account for the full range of textures obtained in f.c.c. metals over a range of stacking-fault energy.
Restoration of insulin receptor improves diabetic phenotype in T2DM mice (2019)

Type 2 diabetes mellitus (T2DM), also known as adult-onset diabetes, is characterized by ineffective insulin action due to insulin resistance in key metabolic tissues. Insulin receptor (IR) plays an important role in insulin signal transduction, defect of which has been considered the fundamental cause of T2DM. IR content reduction in diabetes is one key contributor to the defective insulin signaling and diabetes progression. Rescuing IR levels by transgenic complementation has not been considered as a treatment option because it is limited by uncontrollable expression level, tissue selectivity, or developmental defects. In the current study, we demonstrated that single-dose adeno-associated virus (AAV) vector delivered expression of human IR (hIR) in the liver of inducible IR-knockout mice and significantly improved the diabetic phenotype caused by IR deletion during adulthood. Such an approach was also applied, for the first time to our knowledge, to treating ob/ob mice, a model of severe T2DM attributed to superfluous calorie intake and insulin resistance. Interestingly, similar treatment with AAV-hIR had no obvious effect in healthy animals, indicative of low hypoglycemic risk as a consequence of potential excessive insulin action. The results described here support restoration of IR expression as a safe and effective T2DM therapeutic with a long-lasting profile.
Machine learning for cell classification and neighborhood analysis in glioma tissue (2021)

Abstract Multiplexed and spatially resolved single-cell analyses that intend to study tissue heterogeneity and cell organization invariably face as a first step the challenge of cell classification. Accuracy and reproducibility are important for the down-stream process of counting cells, quantifying cell-cell interactions, and extracting information on disease-specific localized cell niches. Novel staining techniques make it possible to visualize and quantify large numbers of cell-specific molecular markers in parallel. However, due to variations in sample handling and artefacts from staining and scanning, cells of the same type may present different marker profiles both within and across samples. We address multiplexed immunofluorescence data from tissue microarrays of low grade gliomas and present a methodology using two different machine learning architectures and features insensitive to illumination to perform cell classification. The fully automated cell classification provides a measure of confidence for the decision and requires a comparably small annotated dataset for training, which can be created using freely available tools. Using the proposed method, we reached an accuracy of 83.1% on cell classification without the need for standardization of samples. Using our confidence measure, cells with low-confidence classifications could be excluded, pushing the classification accuracy to 94.5%. Next, we used the cell classification results to search for cell niches with an unsupervised learning approach based on graph neural networks. We show that the approach can re-detect specialized tissue niches in previously published data, and that our proposed cell classification leads to niche definitions that may be relevant for sub-groups of glioma, if applied to larger datasets.
Synthesis and plant growth-promoting activity of brassinolide analogues. (1981)

The analogues of brassinolide, 15, 19-23, 29 and 30, were synthesized via key intermediate 5 from stigmasterol. Compound 15 which has the same functional groups as brassinolide on rings A and B showed one tenth of the activity of brassinolide in the lamina inclination test on rice seedlings. However, other analogues with modified ring A were poorly active, and an analogue with modified ring B, 6-oxa-ketone 30, showed only one hundredth of the activity of its 7-oxa-ketone isomer, 29, suggesting that the 2α, 3α-dihydroxy-7-oxa-6-ketone moiety is one of the requisites for the biological activity.
Pomegranate juice to reduce fecal calprotectin levels in inflammatory bowel disease patients with a high risk of clinical relapse: Study protocol for a randomized controlled trial (2019)

ClinicalTrials.gov, NCT03000101 . Registered on 21 December 2016.
Radar polarization comparisons in sea-clutter suppression by decorrelation and constant false alarm rate receivers (1969)

An X-band radar with back-to-back horizontally and vertically polarized antennas of equal gain and beamwidths was built. The antennas were enclosed in a symmetrical aerodynamic radome permitting speeds of rotation from 20 rev/min to 600 rev/min. The radar power was switched every half revolution from one antenna to the other, so that a sea-clutter picture presented on the top 180° of the p.p.i. display was identically repeated on the lower 180°, but with the orthogonal polarization. Some of the different characteristics of sea-clutter on the two polarizations were strikingly illustrated by this virtually simultaneous presentation. The sea-clutter smoothing effects obtained by decorrelation and integration are demonstrated. The r.m.s. sea-clutter amplitude was brought down to that of the noise by a true i.f. (amplifying logarithmically at the input frequency) type of constant false alarm rate (c.f.a.r.) receiver developed during this work. Recent work on logarithmic receivers has shown that the output noise fluctuations do not always become constant and independent of input r.m.s. noise amplitude, even though a near perfect logarithmic input-output law may be obtained on pulse or continuous wave (c.w.) inputs. The performance of the true i.f. logarithmic amplifier has been investigated using a wide-band noise source (the output of which may be varied through 50 dB) to feed the amplifier. The conditions which must be observed if the output noise fluctuations are to remain constant while the input noise varies over this range have been established. When these conditions are met there is no significant impairment of detectability of weak signals against noise when using a logarithmic receiver, compared with a linear receiver.
Apparent Diffusivity of Copper Ions in Copper Chevrel Phase Compound-Synthetic Rubber Composite Electrode (1992)

Potential sweep and current pulse measements were carried out to evalute the apparent diffusivity of copper ions in the sheet_form composite electrode which consisted of copper Chevrel phase compound of Cu2Mo6S78copper ion conductive solid electrolyte of Rb4Cu617C113andsyntheticrubberbinderThediffusivitydependedntheptentialfthe electrode and the mixing amount ofthe solid electrolytel a larger value of5010-9cm2sec was obtained at O051V(vs Cu)for the electrode with50wtsolid electrolyteand a smaller valueofO13109cm2secatO509V(vsCu)fbrtheelectrodewith2Gwtsoli(1electrolyte
The CPEB3 ribozyme modulates hippocampal-dependent memory (2021)

Abstract A self-cleaving ribozyme mapping to an intron of the cytoplasmic polyadenylation element binding protein 3 ( CPEB3 ) gene has been suggested to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. The ribozyme’s self-scission half-life matches the time it takes an RNA polymerase to reach the immediate downstream exon, suggesting that the ribozyme-dependent intron cleavage is tuned to co-transcriptional splicing of the CPEB3 mRNA. Here we report that the murine ribozyme modulates its own host mRNA maturation in both cultured cortical neurons and the hippocampus. Inhibition of the ribozyme using an antisense oligonucleotide leads to increased CPEB3 protein expression, which enhances polyadenylation and translation of localized plasticity-related target mRNAs, and subsequently strengthens hippocampal-dependent long-term memory. These findings reveal a previously unknown role for self-cleaving ribozyme activity in regulating experience-induced co-transcriptional and local translational processes required for learning and memory.
Space time frequency coded (STF) OFDM for broadband wireless communication systems (2011)

The current problems in wireless systems are multi-path propagation, frequency selective fading, Inter-Symbol Interference (ISI) and Inter-Carrier Interference (ICI), with the major challenge being transmission of information having high data rates over long distances. The Orthogonal Frequency Division Multiplexing (OFDM) systems solve a few of the above stated problems by the use of diversity schemes, which increase the reliability and security of the message. By adopting Multiple-Input Multiple-Output (MIMO) and OFDM technologies, wireless systems could reach data rates up to several hundreds of Mbps and achieve spectral efficiencies of several tens of bits/Hz/s, which are unattainable for conventional Single-Input Single-Output (SISO) systems. This paper deals with the simulation of Space Time Frequency (STF) coded OFDM system. The coding schemes like Space Time (ST), Space Frequency (SF) and Space Time Frequency (STF) coding are compared and from the results it is proved that STF scheme performs better than ST and SF schemes. The Space Time Frequency coded communication system when is used along with diversity schemes like MIMO and Multiple Input Single Output (MISO) is compared for their performance over a fading channel having inherent noise, and it is further proved that MIMO performs better than MISO schemes.
A Flexible Remote Electronics Laboratory (2005)

The Internet provides new possibilities for universities and other teaching organizations to share laboratories equipped with expensive instruments. A remotely operated electronics laboratory has been set up by Blekinge Institute of Technology in Sweden. The laboratory is a client/server application and the Internet is used as the communication infrastructure. In the new version presented in this paper security problems are solved and an authentic appearance of instruments and components are provided. Most remote electronics laboratories elsewhere offer fixed experiments but in this one, students can simultaneously assemble circuits and conduct experiments much like they do in a traditional university laboratory. The laboratory is always open and can be used by registered students and guest users around the world.
Ellipsometric study of single-crystal γ-InSe from 1.5 to 9.2 eV (2010)

We report the component E⃑⊥ĉ of the pseudodielectric-function tensor ⟨ε(E)⟩=⟨ε1(E)⟩+i⟨ε2(E)⟩ of γ-phase single-crystal InSe, obtained from 1.5 to 9.2 eV by vacuum-ultraviolet spectroscopic ellipsometry with the sample at room temperature. Overlayer artifacts were reduced as far as possible by measuring fresh surfaces prepared by cleavage. Accurate critical-point energies of observed structures were obtained by a combined method of spectral analysis.
Investigation of mask absorber induced image shift in EUV lithography (2019)

With the introduction of EUV lithography into early manufacturing, the lithography community still struggles with some imaging issues, like the magnitude of usable depth of focus, and reduced contrast which can impact stochastic effects such as defectivity and line edge roughness. In recent years EMF mask effects and their impact on best focus shift in EUV lithography were investigated, and alternative absorber stacks were proposed in order to improve control of focus and contrast. Recently, interest in phase shifting masks has resurfaced, and there are proposals for alternative absorber stacks that depend on feature type to be patterned. In this paper, we investigate the phenomenon that for a dipole the separate images of the two monopoles do not overlap with each other. This means that the contrast for the dipole is measurably lower than that of the individual monopoles. We discuss the impact of this effect on contrast and usable depth of focus, propose a method to measure this image split effect, and investigate which absorber materials can reduce it. One approach to suppressing the image split has been the choice of a material that is index matched to vacuum, which therefore shows a negligible image split behavior. While this image split is indeed largely suppressed for absorbers with n &asymp; 1, those materials have markedly low intrinsic image contrast, making them unsuitable as absorbers. Instead, we have converged on absorbers that create either a significant phase shift or feature very strong absorption, with recent proposals coming close to a &pi; phase shift for attPSM. We hypothesize that the close index match to vacuum is detrimental to imaging because a larger part of the light is absorbed which would otherwise have contributed to imaging.
Anhang B: Werkstoffdatenblätter mit Zeitstanddaten für Ni-Basis-Legierungen (2019)

No AccessZeitstandverhalten von metallischen WerkstoffenMar 2019Anhang B: Werkstoffdatenblätter mit Zeitstanddaten für Ni-Basis-LegierungenUlrich BrillUlrich Brillhttps://doi.org/10.3139/9783446459854.014SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2019Pages: 245-308Print ISBN: 978-3-446-45531-3eISBN: 978-3-446-45985-4 Copyright & Permissions© 2019 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
A case study of the influence of shadows and shading on multispectral airborne imaging data. (1997)

Non-uniform illumination due to three-dimensional shape of land surface and land coverage can cause seriously falsified results when remote sensing data are analyzed automatically, whereas shadow borders and shading patterns are highly informative image features for photogrammetric applications. In this study, the influence of shading and shadows on the radiance measured by a Compact Airborne Spectrographic Images (casi) is investigated. the image data were recorded in the visible and near infrared wavelength range and have a high spectral, spatial and radiometric resolution. We examine the feasibilty of an information extraction from strongly shaded areas based on histrogram properties of shaded image regions and by estimating the noise performance of the imager. We show, that the numerical information content of shaded image areas is only reduced by a small factor compared with well illuminated regions. Analyzing shaded surfaces can be performed with acceptable signal to noise rations using high radiometric resolution sensors. We discuss our findings with respect to the problem of detecting illumination variations and present results of a detection algorithm based on thresholding and a multispectral gradient classification procedure.