gebhart/patrepeval huggingface dataset:
Efficiency of MIMO configuration and adaptive optics corrections in free space optical fading channels (2009)

Free Space Optical (FSO) communications is the only practical candidate for realizing universal network coverage between ground and airborne nodes, satellites, and even moon and other nearby planets. When atmosphere (be it the earth or Mars) is a part of the optical channel, attributes of scattering and turbulence bring about amplitude attenuation, and scintillation, as well as beam wander and phase aberrations at the receiving aperture. Phase screens are usually used in order to simulate the atmospheric fading channel and phase fluctuations. In this paper, different methods of generating phase screens are compared based on their accuracy and computational complexity, as in most computer simulations, a large ensemble of phase screens are required for averaging purposes. To combat the focal plane intensity fading, caused by amplitude and phase variations in the received wave-front, it is possible to replace the Single Input-Single Output (SISO) communications system with its Multiple Input Multiple Output (MIMO) equivalent, which has the same total transmit power and receiving aperture area. Another alternative is to equip the receiver with a state of the art Adaptive Optics (AO) correction system. Using average Bit Error Rate (BER), as a performance metric, effectiveness of these two approaches are compared and it is shown that while a MIMO configuration outperforms a basic AO system capable of only tilt corrections, an ideal AO system, which is able to remove higher orders of Zernike modes can asymptotically perform as well as an equivalent MIMO configuration.
Irreversible enzyme inhibitors. CX. Candidate irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine. 4 (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIrreversible enzyme inhibitors. CX. Candidate irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine. 4Bernard Randall Baker and Gerhardus J. LourensCite this: J. Med. Chem. 1968, 11, 1, 34–37Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/jm00307a006https://doi.org/10.1021/jm00307a006research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simplified binary cat swarm optimization (2020)

Inspired by the biological behavior of domestic cats, the Cat Swarm Optimization (CSO) is a metaheuristic which has been successfully applied to solve several optimization problems. For binary problems, the Boolean Binary Cat Swarm Optimization (BBCSO) presents consistent performance and differentiates itself from most of the other algorithms by not considering the agents as continuous vectors using transfer and discretization functions. In this paper, we present a simplified version of the BBCSO. This new version, named Simplified Binary CSO (SBCSO) which features a new position update rule for the tracing mode, demonstrates improved performance, and reduced computational cost when compared to previous CSO versions, including the BBCSO. Furthermore, the results of the experiments indicate that SBCSO can outperform other well-known algorithms such as the Improved Binary Fish School Search (IBFSS), the Binary Artificial Bee Colony (BABC), the Binary Genetic Algorithm (BGA), and the Modified Binary Particle Swarm Optimization (MBPSO) in several instances of the One Max, 0/1 Knapsack, Multiple 0/1 Knapsack, SubsetSum problem besides Feature Selection problems for eight datasets.
Immunomodulatory drug FTY720 induces regulatory CD4+CD25+ T cellsin vitro (2009)

As a novel immunosuppressant, FTY720 (2-amino-2-(2-[4-octylphenyl] ethyl)-1, 3-propanediol hydrochloride) has been used to prevent the allograft rejection in organ transplantation. FTY720 can prolong markedly survival of the allograft by inducing apoptosis of reactive lymphocytes and by redirecting the homing of lymphocytes. However, as the archetype of a new class of immune modulators, the potential effect of FTY720 on the immune response needs to be elucidated further. In this study, FTY720 was added into the mixed lymphocyte reaction (MLR) consisting of murine splenocytes from BALB/c and C57BL/6, to observe its direct effect on the induction of CD4(+)CD25(+) regulatory T cells. It was demonstrated that the proportion of CD4(+)CD25(+) and CD4(+)CD25(+)forkhead box P3 (FoxP3)(+) T cells in MLR were increased significantly by FTY720 treatment, and the expression of FoxP3 mRNA in lymphocytes was also enhanced markedly by the drug. A synergetic effect was observed between FTY720 and co-stimulation blockades. Moreover, analysis of the function of FTY720-treated cells manifested an increased suppressive activity in an in vitro antigen-specific proliferation assay. In conclusion, FTY720 can increase the number and enhance the functional activity of CD4(+)CD25(+) regulatory T cells in MLR, and these FTY720-treated cells possess the activity to down-regulate the alloreactivity of lymphocytes, indicating its potential use for therapeutic purposes.
Dermatological diseases affecting fishes of the Tar-Pamlico Estuary, North Carolina (1991)

Over the last several years, various epidemic dermatological diseases have been observed in fishes of the Tar-Pamlico estuary. The most important is ulcerative mycosis, an infection associated with oomycete fungi that affects Atlantic menhaden Brevoortia tyrannus. In the present report we describe lesions resembling ulcerative mycosis in other estuarine species such as southern flounder Paralichthys lethostigma, hickory shad Alosa medjocrjs, striped bass Morone saxatilis, bluefish Pomatomus saltatrix, Atlantic croaker Micropogon~as undulatus, weakfish Cynoscion regalis, spot Leiostomus xanthurus, silver perch Ba~rdella chrysura, plnf~sh Lagodon rhomboides, and hogchoker Trinectes maculatus. Less prevalent dernlatological diseases were also ~bserved~including lymphocystis, bacterial dermatitis and myositis, Argulus dermatitis, Henneguya myositis, and various idiopathic dermatopathies. Only one tumor, a fibroma, was seen. The occurrence of many of these diseases is of concern to fisheries managers because of their potential impact upon estuarine fish populations. Many environmental problems (noxious algae blooms, increasing turbidity, anoxic/hypoxic events, loss of submerged aquatic vegetation, etc.) plague the Tar-Pamlico estuary. The relationship of the observed diseases to these environmental problems is presently unknown.
In vivo inhibition of Maillard protein fluorescence by acetylarginine: possible multiplicity of mechanisms (2000)

Conference Abstract| October 01 2000 In vivo inhibition of Maillard protein fluorescence by acetylarginine: possible multiplicity of mechanisms G. Suárez; G. Suárez 1New York Medical College, Valhalla, NY 10595, USA Search for other works by this author on: This Site PubMed Google Scholar C. Raventós-Suárez; C. Raventós-Suárez 1New York Medical College, Valhalla, NY 10595, USA Search for other works by this author on: This Site PubMed Google Scholar R. Devés R. Devés 2Instituto de Ciencias Biomédicas, Santiago, Chile Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A204. https://doi.org/10.1042/bst028a204b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation G. Suárez, C. Raventós-Suárez, R. Devés; In vivo inhibition of Maillard protein fluorescence by acetylarginine: possible multiplicity of mechanisms. Biochem Soc Trans 1 October 2000; 28 (5): A204. doi: https://doi.org/10.1042/bst028a204b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
A Chemical Approach to Protein Design—Template‐Assembled Synthetic Proteins (TASP) (1989)

Abstract Advances in methodology in both chemistry and molecular biology allow us to take a fresh look at protein science. Chemical synthesis of peptides and site‐directed mutagenesis are now standard research tools, paving the way for the construction of new proteins with tailor‐made structural and functional properties. The decisive hurdle on the way lies not in the synthesis of the molecules proper but rather in a better understanding of the complex folding pathways of polypeptide chains into spatially well‐defined structures. Can the chemist use his synthetic tools to bypass the notorious “folding problem?” In this article, we present a new approach developed in our laboratory, which opens a chemical route to artificial proteins with predetermined three‐dimensional structures, allowing a first step towards the synthesis of new proteins with functional properties.
14XX nm-wavelength electrically-pumped VECSELs fabricated by wafer fusion (2013)

We report on the design, fabrication and characterization of electrically pumped vertical external cavity surface emitting lasers (EP-VECSELs) emitting at 1470 nm. We demonstrate 6.2 mW of CW output power, which represents the highest power value reported so far for EP-VECSELs in the 14XX nm and 15XX nm wavelength bands.
TiO2 thin Films for Biofouling Applications (2017)

This work presents a study of TiO2 thin films prepared by sputtering, for using as protection for biofouling action on marine structures. Titanium oxide thin films were prepared with different amount of oxygen on the surface of regular 1020 steel, a structural material for marine technology. The cristalline structure analysis evidenced the formation of anatase and rutile phases, as well as an amorphous phase of titanium oxide. Roughness measurements shown that the surface finish can contribute to the fixation of microorganisms. The crystalline TiO2 thin films was evaluated as a potential biofouling protective coating. Contact angle measurements revealed that under UV-C light, the material evidenced a changing in wettability from hydrophobic to hydrophilic behavior, what is associated to the activation of photocatalytic reactions that is nocive for living beings on its surface. The effect of marine ambient on sample corroborates this conclusion, where after 6 months of exposure it was not sufficient for growing of biofouling on surface.
Monoclonal antibody-mediated inhibition of HIV-1 reverse transcriptase polymerase activity. Interaction with a possible deoxynucleoside triphosphate binding domain (1993)

A series of monoclonal antibodies against p51/p66 human immunodeficiency virus-1 (HIV-1) reverse transcriptase (RT) were prepared by immunizing mice with the native enzyme immobilized on nitrocellulose. One of these antibodies, designated 1E8, was found to inhibit both RNA-dependent and DNA-dependent polymerase activities of RT but had no effect on the RNase H activity of the enzyme. This inhibition was noncompetitive with respect to primer/template and competitive with respect to deoxynucleoside triphosphate (dNTP). The extent of 1E8 inhibition of RT polymerase activity decreased with increasing concentrations of dNTP in the incubation but was not affected by changes in primer/template concentration. 1E8 bound equally well in solution to both free RT and to the RT-primer/template complex. However, binding to the latter was significantly reduced by the addition of increasing concentrations of dNTP. The ability of dNTP to inhibit the interaction of 1E8 with the RT-primer/template complex was dependent on the identity of the homopolymeric primer/template used; only that dNTP complementary to the template was effective in this respect. 1E8 bound to the p51/p66 reverse transcriptase heterodimer in solution and reacted with both p51 and p66 subunits of reverse transcriptase on Western blots. The antibody is therefore presumed to recognize a linear surface epitope on the enzyme. 1E8 was found to specifically recognize a peptide with the sequence KKDSTKWRK. This sequence corresponds to residues 65-73 of HIV-1 reverse transcriptase, a region identified as highly antigenic by several computer algorithms. Two mutations within this sequence have been identified with resistance to 3'-azido,3'-deoxythymidine. We conclude that residues 65-73 of HIV-1 reverse transcriptase may be at or near the polymerase active site of the enzyme, and may form part of the deoxynucleoside triphosphate binding domain of the enzyme.
Chicken T‐Cell Growth Factor: Use in the Generation of a Long‐Term Cultured T‐Cell Line and Biochemical Characterization (1986)

Supernatants from concanavalin A (Con A)-stimulated chicken spleen cells were used to generate a long-term cultured cell line from antigen-primed chicken peripheral blood leukocytes. This line has been kept in continuous proliferation in vitro for more than 25 weeks. Morphologically these cells were lymphoblastoid and expressed class I and class II antigens of the major histocompatibility complex as well as T-cell (but not B-cell or macrophage) antigens. In addition they contained no peroxidase or non-specific esterase activity, neither were they phagocytic. Proliferation of the line was totally dependent on exogenous T-cell growth factor (TCGF) activity provided by the Con-A-stimulated spleen cell supernatant, comparable with the proliferation of Con-A-induced T-cell blasts. TCGF activity from the supernatant was absorbed both by the long-term cultured T cells and by Con A blasts, demonstrating the presence of receptors for the same TCGF species on the two populations. We have used the long-term cultured cell line to characterize chicken TCGF further. The molecular weight of the biologically active fractions found by gel filtration on Sephadex G-100 was approximately 13,000 and isoelectric focusing showed chicken TCGF to have a pI of pH 5.9. We propose that the TCGF described here is the chicken analogue to the mammalian interleukin 2.
Chemical Composition of Lipophilic Extractives from Eucalyptus globulus Labill. Wood (1999)

Summary The composition of lipophilic extractives in the chloroform soluble fraction of the acetone extract from Eucalyptus globulus wood has been examined. The lipid extract was fractionated by solid-phase extraction on aminopropyl-phase cartridges into four different fractions of increasing polarity. The total lipid extract and the resulting fractions were analyzed by gas chromatography and gas chromatography-mass spectrometry, using high temperature capillary columns. The main compounds identified included sterols, sterol esters, fatty acids, steroid ketones, hydrocarbons and triglycerides. Minor compounds such as fatty alcohols, mono- and diglycerides, waxes and tocopherols were also identified among the lipids from E. globulus wood.
Molecular Alterations in Lung Adenocarcinoma With Ground-Glass Nodules: A Systematic Review and Meta-Analysis (2021)

Somatic genetic alterations are considered in early-stage GGO patients without distinct changes of the frequency following the progress of the tumor. This review sheds insight on molecular alterations in LUAD with GGOs.
"Receiver makes right" data conversion in PVM (2002)

Using a receiver makes it right (RMR) data conversion technique in PVM significantly improves the message-passing performance in heterogeneous environments. The improvements are due to two factors: (1). RMR reduces the need for conversions in a heterogeneous environment; (2). At most each message is converted, only once compared to twice for XDR used in public version of PVM, and our conversion routines are streamlined and are several times faster than the XDR routines. The drawback to RMR is the potential need for a large number of conversion routines. We demonstrate that only a small number of routines are required because many vendors use the IEEE standard for data representation. Given this fact, RMR may emerge as a promising technique in distributed computing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ILI: an adaptive infrastructure for dynamic interactive distributed applications (2002)

Addresses the middleware that is necessary to realize the construction of distributed laboratories in which scientists can construct and use complex computations and then analyze and share their results across geographically separated collaborations. We present a model of such middleware for heterogeneous distributed computing platforms and also show how middleware can dynamically adapt to changes in the behavior of instruments and end users. To address the demands of applications executing in a distributed laboratory, we have developed an infrastructure, called ILI (Interactivity Layer Infrastructure), that can dynamically adapt to changes in the behavior of the computational instruments and end users across a shared and dynamically changing set of computational nodes and networks.
ChemInform Abstract: Single Crystal Growth of CaMn2O4 and CaMn3O6 in Molten CaCl2. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Expression of a Functional C5a Receptor in Regenerating Hepatocytes and Its Involvement in a Proliferative Signaling Pathway in Rat (2004)

Activation of the complement system generates the anaphylatoxin C5a whose activities are mediated through its binding to the widely expressed C5aR. C5aR mRNA and protein expressions are known to be induced in rat hepatocytes under inflammatory conditions. However, little is known about the role of the C5a/C5aR complex in liver and its involvement during a proliferative process. We have evaluated the expression of C5aR in regenerating rat hepatocytes following a partial hepatectomy and in hepatocyte cultures. C5aR induction was observed in hepatocytes from regenerating liver, as well as in normal hepatocytes under a culture-induced stress. The effect of a stimulation by a C5a agonist upon the synthesis of a growth factor/receptor pair (hepatocyte growth factor/c-Met) was also evaluated. Our data demonstrated an up-regulated expression of hepatocyte growth factor and c-Met mRNAs, but we failed to observe a direct mitogenic effect of C5a in culture. However, a significantly increased expression of cyclin E and D1mRNA levels, as well as an increased BrdU incorporation, were observed in rats given an i.v. C5a agonist injection following an 80% partial hepatectomy. These studies demonstrate for the first time that: 1) C5aR is up-regulated during liver regeneration, 2) the binding of C5a to C5aR promotes a growth response, and 3) C5aR is involved in a cell cycle signaling pathway. Taken together, these findings point to a novel role for the hepatic C5aR implicating this complement system in the context of normal or abnormal proliferative pathways.
Characterization of LQG Differential Games with Different Information Patterns (2007)

This chapter contains sections titled: Introduction Formulation of the discrete-time LQG game Solution of the LQG game as the limit to the LEG Game LQG game as the limit of the LEG Game Correlation properties of the LQG game filter in the limit Cost function properties—effect of a perturbation in up Performance of the Kalman filtering algorithm Comparison with the Willman algorithm Equilibrium properties of the cost function: the saddle interval Conclusion Acknowledgements References
Buoyancy-based separation of antigen-specific T cells (2016)

This project focuses on the proof-of-concept development of a separation construct to isolate antigen-specific CD4 T cells using a buoyant lipid microparticle (microbubble) reagent attaching major histocompatibility complex class II (MHCII) molecules. These cells are implicated in the progression of cardiovascular disease. The project relied critically on preexisting reagents produced by collaborators: microbubbles and biotinylated recombinant MHCII monomers.Current cell separation methods rely primarily on either magnetic separation or flow-cytometry based sorting. The method presented here provides the basis for a new avenue of investigation using a principally different separation scheme based on buoyancy. It is intended to be extensible to the separation of antigen-specific T cells in other contexts and was originally intended to be a removable separation reagent (unsuccessful). The ultimate goal is the development of a separation system which may be used to further clinical work or research relying on cell isolation.Here, the buoyancy-based method is first used to perform bulk B and CD4 T cell separations. These are common lab procedures for which many commercial kits are available, which made them an ideal testbed for initial study. Flow cytometric analysis and confocal microscopy were performed to confirm successful cell enrichment. The separation system was then further developed to separate antigen-specific CD4 T cells reactive to the endogenous murine peptide P6 (TGAYSNASSTESASY), relevant in the study of atherosclerosis. Flow cytometric and microscopic confirmation of successful separation was performed in this section as well.Several devices for centrifugation were designed and constructed in the course of this project. These attempted to create a pendant droplet between the buoyant and non-buoyant fractions in a single column of liquid formed by centrifugation, allowing for these layers to be completely sequestered from one another. Though these devices were unsuccessful, they merit further study. Another device, a centrifuge adapter, was created as an all-purpose experimental aid to hold and centrifuge all combinations of reagent tubes used in the cell separation protocol. Computer graphics animations and diagrams of various facets of the project were also made, including molecular-scale models of separation constructs derived from Protein Data Bank (PDB) structural data.