gebhart/patrepeval huggingface dataset:
Factors Associated with Post-Transplant Active Epstein-Barr Virus Infection and Lymphoproliferative Disease in Hematopoietic Stem Cell Transplant Recipients: A Systematic Review and Meta-Analysis (2021)

This systematic review was undertaken to identify risk factors associated with post-transplant Epstein-Barr virus (EBV) active infection and post-transplant lymphoproliferative disease (PTLD) in pediatric and adult recipients of hematopoietic stem cell transplants (HSCT). A literature search was conducted in PubMed and EMBASE to identify studies published until 30 June 2020. Descriptive information was extracted for each individual study, and data were compiled for individual risk factors, including, when possible, relative risks with 95% confidence intervals and/or <i>p</i>-values. Meta-analyses were planned when possible. The methodological quality and potential for bias of included studies were also evaluated. Of the 3362 titles retrieved, 77 were included (62 for EBV infection and 22 for PTLD). The overall quality of the studies was strong. Several risk factors were explored in these studies, but few statistically significant associations were identified. The use of anti-thymocyte globulin (ATG) was identified as the most important risk factor positively associated with post-transplant active EBV infection and with PTLD. The pooled relative risks obtained using the random-effect model were 5.26 (95% CI: 2.92-9.45) and 4.17 (95% CI: 2.61-6.68) for the association between ATG and post-transplant EBV infection and PTLD, respectively. Other risk factors for EBV and PTLD were found in the included studies, such as graft-versus-host disease, type of conditioning regimen or type of donor, but results are conflicting. In conclusion, the results of this systematic review indicate that ATG increases the risk of EBV infection and PTLD, but the link with all other factors is either nonexistent or much less convincing.
Time Needed for Treatment Is the Major Predictor of Quality of Life in Psoriasis (2010)

Treatment burden requires special attention when quality of life in psoriasis is to be improved. Since the larger part of variance is left unexplained, further factors predicting quality of life have yet to be detected.
Low frequency intensity noise characterization of an all fiber single frequency erbium ring laser (1992)

Erbium doped fiber ring lasers are drawing increasing interest because of their narrow linewidth, broad tunability, and inherent compatibility with optical fiber. We have recently developed such a laser that is broadly tunable (&gt;30 nm) and stable from mode hopping for a period of time on the order of minutes in spite of having a cavity length on the order of 30 m. This is achieved through the use of tandem fiber Fabry-Perot filters. One broadband filter (30 GHz bandwidth, 30 nm free spectral range) provides tuning. The other narrowband filter (125 MHz bandwidth, 10 GHz free spectral range) provides sufficient loss difference between cavity modes to achieve a sidemode suppression greater than 50 dB. We report here on the low frequency intensity noise characteristics of this device. The relaxation oscillation frequency has been characterized as a function of laser power. It is found to vary as the square root of laser power, as expected. The relaxation oscillation frequency varies from 10 kHz to 30 kHz when the laser power is varied from 0.088 mW to 0.840 mW. Mode hopping amplitude instabilities were also investigated. When the broadband tuning element was tuned so as to give approximately equal loss to two competing modes one narrowband filter free spectral range apart, a sustained, large amplitude oscillation was observed. The oscillation has a power dependence similar to that of the relaxation oscillation frequency.
ChemInform Abstract: STEREOCHEMISTRY OF IODOFLUORINATION OF PHENYL‐SUBSTITUTED OLEFINS WITH (DIFLUOROIODO)METHANE (1976)

Abstract Die Jodfluorierung der substituierten cis‐(I) bzw. trans‐Olefine (II) mit Difluorjodmethan ‐ erhältlich aus Xenondifluorid (III) und Methyljodid (IV) ‐ erfolgt mit Markownikoff‐Selektivität und anti‐Stereospezifität: Mit (Ia)‐(Ic) werden die threo‐(VI), aus (II) werden die erythro‐Verbindungen (VII) gebildet.
Magnetoresistance ofc-axis-oriented epitaxialYBa2Cu3O7−xfilms aboveTc (1989)

Magnetoresistance in high-quality single-crystal films of ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathrm{x}}$ studied in a temperature range ${T}_{c}$\ensuremath{\lesssim}T\ensuremath{\lesssim}210 K is presented for magnetic field configurations both parallel and perpendicular to the conducting ab plane. The data are analyzed in terms of recent theories of superconducting fluctuations considering both orbital and Zeeman effects in Aslamazov-Larkin and Maki-Thompson terms. From the analysis, the phase-breaking time of carriers is determined to be ${\ensuremath{\tau}}_{\ensuremath{\rho}}$=(1\ifmmode\pm\else\textpm\fi{}0.1)\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}13}$ sec at 100 K with a T dependence of 1/${\ensuremath{\tau}}_{\ensuremath{\rho}}$\ensuremath{\propto}${T}^{1\mathrm{\ensuremath{-}}2}$. ${\ensuremath{\xi}}_{c}$(0)=1.5\ifmmode\pm\else\textpm\fi{}0.5 A\r{} and ${\ensuremath{\xi}}_{\mathrm{ab}}$(0) =11.5\ifmmode\pm\else\textpm\fi{}0.5 A\r{} are also derived for the inter- and intralayer coherence lengths.
A principal component analysis ensemble classifier for P300 speller applications (2013)

Recent advances in developing Brain-Computer Interfaces (BCIs) have opened up a new realm for designing efficient systems that could enable disabled people to communicate. The P300 speller is one important BCI application that allows the selection of characters on a virtual keyboard by analyzing recorded electroencephalography (EEG) activity. In this work, we propose an ensemble classifier that uses Principal Component Analysis (PCA) features to identify evoked P300 signals from EEG recordings. We examine the performance of the proposed method, using different linear classifiers, on the datasets provided by the BCI competition III. Results demonstrate a classification accuracy of 91% using the proposed method. In addition, our results indicate a significant improvement in classification accuracy compared to traditional feature extraction and classification approaches. The proposed method results in low across-subjects variability compared to other methods with minimal parameter tuning required which could be useful in mobile platform P300 applications.
[Orthodontic contribution in sleep apnea]. (1997)

This study details the role that the orthodontist can play, when faced with sleeping obstructive apneas and snoring phénomena. Of special importance are knowledge of cranio-facial growth, radiographic exam and cephalometric analysis: they mainly help to understand all the aspects of this specific syndrome, and reveal the interest for a neuro-orthodontic or a neuro-surgical orthodontic approach.
Abstract WMP54: Cerebrovascular Accidents in Patients With a Left Ventricular Assist Device (2016)

Background: Cerebrovascular accidents (CVAs), including ischemic stroke, transient ischemic attack, and intracranial hemorrhage, are major and devastating complications of left ventricular assist devices (LVADs). However, little is known about their incidence and risk factors. Materials and methods: We retrospectively reviewed the medical records of 75 consecutive cases supported with a LVAD (mean age of 39 years, 60 men, paracorporeal pulsatile-flow LVAD in 31, implantable centrifugal-flow in 18, and implantable axial-flow in 26) in our institution between December 2009 and June 2014. The incidence rate of CVAs was estimated as events per patient-year, and baseline characteristics (age, sex, etiologies of heart failure, comorbid diseases, and types of LVAD) were assessed to determine their contribution to the incidences of total, ischemic and hemorrhagic CVAs. Results: During 113.7 patient-years of observation, a total of 59 CVA events (26 hemorrhagic and 33 ischemic) were identified in 31 cases, yielding an incidence rate of 0.52 events per patient-year. Univariate negative binomial regression (NBR) analysis demonstrated that patients with an axial-flow LVAD had significantly lower incidence of total CVAs [incidence rate ratio (IRR) 0.29, 95% confidence interval (CI) 0.10 - 0.88, p=0.03] and subsignificantly of both of ischemic (0.30, 0.05 - 1.69, p=0.17) and hemorrhagic CVAs (0.29, 0.08 - 1.02, p=0.05) than those with a paracorporeal LVAD (reference), whereas those with a centrifugal-flow LVAD did not. Patients with diabetes had a significantly higher incidence of total CVAs (IRR 2.39, 95% CI 1.03 - 5.57, p=0.04) and ischemic CVAs (4.01, 1.31 - 12.2, p=0.02) than those without diabetes but not of hemorrhagic CVAs (1.41, 0.54 - 3.66, p=0.48). Results of multivariate NBR analysis were similar with those of univariate analysis. Conclusion: Among patients on LVAD support, CVA occurred at a rate of 0.52 events per patient-year. Axial-flow LVADs reduced the incidence of CVAs, regardless of ischemic or hemorrhagic subtype, compared with paracorporeal LVADs. Diabetes was associated with an increased risk of CVAs, but the influence was different between ischemic and hemorrhagic CVAs.
The Regulator of G Protein Signaling Family (2000)

Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. The major mechanism whereby RGS proteins negatively regulate G proteins is via the GTPase activating protein activity of their RGS domain. Structural and mutational analyses have characterized the RGS/G alpha interaction in detail, explaining the molecular mechanisms of the GTPase activating protein activity of RGS proteins. More than 20 RGS proteins have been isolated, and there are indications that specific RGS proteins regulate specific G protein-coupled receptor pathways. This specificity is probably created by a combination of cell type-specific expression, tissue distribution, intracellular localization, posttranslational modifications, and domains other than the RGS domain that link them to other signaling pathways. In this review we discuss what has been learned so far about the role of RGS proteins in regulating G protein-coupled receptor signaling and point out areas that may be fruitful for future research.
Glucokinase activity in the arcuate nucleus regulates glucose intake (2014)

The brain relies on a constant supply of glucose, its primary fuel, for optimal function. A taste-independent mechanism within the CNS that promotes glucose delivery to the brain has been postulated to maintain glucose homeostasis; however, evidence for such a mechanism is lacking. Here, we determined that glucokinase activity within the hypothalamic arcuate nucleus is involved in regulation of dietary glucose intake. In fasted rats, glucokinase activity was specifically increased in the arcuate nucleus but not other regions of the hypothalamus. Moreover, pharmacologic and genetic activation of glucokinase in the arcuate nucleus of rodent models increased glucose ingestion, while decreased arcuate nucleus glucokinase activity reduced glucose intake. Pharmacologic targeting of potential downstream glucokinase effectors revealed that ATP-sensitive potassium channel and P/Q calcium channel activity are required for glucokinase-mediated glucose intake. Additionally, altered glucokinase activity affected release of the orexigenic neurotransmitter neuropeptide Y in response to glucose. Together, our results suggest that glucokinase activity in the arcuate nucleus specifically regulates glucose intake and that appetite for glucose is an important driver of overall food intake. Arcuate nucleus glucokinase activation may represent a CNS mechanism that underlies the oft-described phenomena of the "sweet tooth" and carbohydrate craving.
Fast booting based on nand flash memory (2012)

Fast booting is an important tool for minimizing the booting time of embedded systems, and a major factor in determining the usability of the systems. Most fast booting tools have focused on minimizing the booting time by optimizing the processing time from the starting stage of the boot loader to mounting stage of the root file system. However, previous research works did not consider read and write overheads of nand flash memory. In this paper we propose an efficient fast booting for embedded systems based on nand flash memory. We also show that the proposed fast booting mechanism has better performance.
Bronchoarterial Inversion (1997)

Pulmonary arteries of the right middle (RML) and right lower (RLL) lobes lie toward the lung periphery relative to their corresponding bronchi, i.e., along their lateral or posterior aspects. In contrast, those of the right upper lobe (RUL) tend to be located along the medial or anterior aspect of the bronchi. We postulate that a reversal of the normal bronchoarterial relationship at the lung base may indicate combined RML and RLL collapse. We evaluated bronchoarterial relation by computed tomography (CT) and posteroanterior (PA) chest radiographs n patients with combined RML and RLL collapse. On PA chest radiographs, an inverse bronchoarterial relationship could be recognized in the lower perihilar region in seven of 10 patients. In the 10 patients with complete collapse of both the RML and RLL, CT disclosed that the normal bronchoarterial relationship of the RUL was preserved, despite caudal extension of the RUL. In no case were arteries visible along the lateral aspect of bronchi. Thus, on frontal radiographs, when the bronchoarterial relationship in the right lower lung is inverse to that of normal subjects, combined collapse is strongly suggested.
Determination of the Glycemic Index of a Weight Loss Meal Plan Program Using Energy Controlled, Pre‐packaged Products (2013)

Background Consumption of low glycemic index (GI) diets has been associated with a range of health benefits including weight loss. Meal plans incorporating pre‐packaged, energy‐controlled, low‐GI products may therefore be a convenient and effective intervention for weight management. However, GI is affected by the degree of food processing. This suggests that a low‐GI diet based on such foods could be difficult to construct. Objective Determine the GI of a meal plan based on a line of prepackaged foods designed to have a low‐GI. Methods Sixty‐six foods, including 16 breakfast, 15 lunch, 13 dinner and 22 snack items, were tested. Groups of ten healthy subjects tested each food once and a control food three times. The GI of test foods was calculated using standard methodology from capillary blood samples obtained at −5, 0, 15, 30, 45, 60, 90, and 120 minutes. GI for the full meal plan was estimated from tested foods and recommended supplemental grocery items. Results 49 foods fell in the low GI range, 13 in the medium and 4 high. Estimated dietary GI of the full meal plan was in the low range (GI = 44). Conclusion This study demonstrated that an energy‐controlled, low‐GI diet can be assembled using a line of pre‐packaged foods, thus providing an option in designing research or clinical interventions requiring a low‐GI diet. Funding Source: Nutrisystem, Inc.
Electronic and Optical Property Control of Polycation/MXene Layer-by-Layer Assemblies with Chemically Diverse MXenes (2021)

MXenes, 2D nanomaterials derived from ceramic MAX phases, have drawn considerable interest in a wide variety of fields including energy storage, catalysis, and sensing. There are many possible MXene compositions due to the chemical and structural diversity of parent MAX phases, which can bear different possible metal atoms "M", number of layers, and carbon or nitrogen "X" constituents. Despite the potential variety in MXene types, the bulk of MXene research focuses upon the first MXene discovered, Ti<sub>3</sub>C<sub>2</sub>T. With the recent discovery of polymer/MXene multilayer assemblies as thin films and coatings, there is a need to broaden the accessible types of multilayers by including MXenes other than Ti<sub>3</sub>C<sub>2</sub>T<sub><i>z</i></sub>; however, it is not clear how altering the MXene type influences the resulting multilayer growth and properties. Here, we report on the first use of MXenes other than Ti<sub>3</sub>C<sub>2</sub>T<i><sub>z</sub></i>, specifically Ti<sub>2</sub>CT<i><sub>z</sub></i> and Nb<sub>2</sub>CT<i><sub>z</sub></i>, for the layer-by-layer (LbL) assembly of polycation/MXene multilayers. By comparing these MXenes, we evaluate both how changing M (Ti <i>vs</i> Nb) and "<i>n</i>" (Ti<sub>3</sub>C<sub>2</sub>T<i><sub>z</sub>vs</i> Ti<sub>2</sub>CT<i><sub>z</sub></i>) affect the growth and properties of the resulting multilayer. Specifically, the aqueous LbL assembly of each MXene with poly(diallyldimethylammonium) into films and coatings is examined. Further, we compare the oxidative stability, optoelectronic properties (refractive index, absorption coefficient, optical conductivity, and direct and indirect optical band gaps), and the radio frequency heating response of each multilayer. We observe that MXene multilayers with higher "<i>n</i>" are more electrically conductive and oxidatively stable. We also demonstrate that Nb<sub>2</sub>CT<i><sub>z</sub></i> containing films have lower optical band gaps and refractive indices at the cost of lower electrical conductivities as compared to their Ti<sub>2</sub>CT<i><sub>z</sub></i> counterparts. Our work demonstrates that the properties of MXene/polycation multilayers are highly dependent on the choice of constituent MXene and that the MXene type can be altered to suit specific applications.
Importance of lipolysis in oral cavity for orosensory detection of fat (2003)

Lingual lipase is usually secreted from von Ebner's glands, although there is great variation between species. Lingual lipase is thought to be an auxiliary enzyme for fat digestion and absorption in mammals; however, the reason for lipolysis in the oral cavity is not known. We focused on the gustatory sense and investigated the significance of lingual lipase in the perception of a fat taste by using orlistat, a potent lipase inhibitor. Five-minute two-bottle preference tests demonstrated that the addition of orlistat diminished the preference for triacylglycerides but not for free fatty acids. Radioactive triolein applied on rats' circumvallate papilla revealed that lingual lipase was released continuously to generate significant amounts of fatty acids and other lipolytic products within 1-5 s, which was enough time to taste fat. These findings suggest that lingual lipase is released to perceive the taste of triacylglycerides and to find nutritive lipids in food.
Multihormonal Regulation of Insulin-Like Growth Factor-I-Related Protein in MCF-7 Human Breast Cancer Cells (1988)

MCF-7 human breast cancer cells have been studied for hormonal regulation of secretion of an insulin growth factor-I (IGF-I)-related growth factor. 17 beta-Estradiol, which is required for tumorigenesis of the cell line in the nude mouse and which stimulates proliferation in vitro, was able to significantly induce IGF-I secretion at 10(-13) M, with maximal induction at 10(-11) M. Under optimal conditions IGF-I could be induced 4-fold after 4 days. Demonstration of estrogenic stimulations required removal of phenol red, a weak estrogen, from the cell culture medium. In addition to estrogen, insulin, epidermal growth factor, and transforming growth factor alpha induce both cellular proliferation and IGF-I secretion, while growth inhibitory antiestrogens, transforming growth factor beta, and glucocorticoids have the opposite effect. In each case, modulations in IGF-I secretion preceeded effects on cellular proliferation. IGF-I was not regulated by human GH, basic fibroblast growth factor, platelet-derived growth factor, or PRL, none of which affected proliferation rate. Thus, regulation of IGF-I secretion in human breast cancer is controlled by different hormones from those previously reported in human fibroblasts. Regulation of IGF-I by neither estrogen nor antiestrogen was associated with changes in steady-state mRNA levels; thus regulation may occur at a step beyond mRNA. We conclude that IGF-I production is tightly coupled to growth regulation by estrogens, antiestrogens, and other hormones and may contribute to autocrine and/or paracrine growth regulation by these agents in breast cancer.
Immersive 4D Interactive Visualization of Large-Scale Simulations (2001)

In dense clusters a bewildering variety of interactions between stars can be observed, ranging from simple encounters to collisions and other mass-transfer encounters. With faster and special-purpose computers like GRAPE, the amount of data per simulation is now exceeding 1TB. Visualization of such data has now become a complex 4D data-mining problem, combining space and time, and finding interesting events in these large datasets. We have recently starting using the virtual reality simulator, installed in the Hayden Planetarium in the American Museum for Natural History, to tackle some of these problem. This work (http://www.astro.umd.edu/nemo/amnh/) reports on our first ``observations'', modifications needed for our specific experiments, and perhaps field ideas for other fields in science which can benefit from such immersion. We also discuss how our normal analysis programs can be interfaced with this kind of visualization.
Some Experimental Methods in Magnetostriction* (1927)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. R. Williams, "Some Experimental Methods in Magnetostriction*," J. Opt. Soc. Am. 14, 383-408 (1927) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Nanocrystal-mediated charge screening effects in nanowire field-effect transistors (2009)

ZnO nanowire field-effect transistors having an omega-shaped floating gate (OSFG) have been successfully fabricated by directly coating CdTe nanocrystals (∼6±2.5 nm) at room temperature, and compared to simultaneously prepared control devices without nanocrystals. Herein, we demonstrate that channel punchthrough may occur when the depletion from the OSFG takes place due to the trapped charges in the nanocrystals. Electrical measurements on the OSFG nanowire devices showed static-induction transistorlike behavior in the drain output IDS-VDS characteristics and a hysteresis window as large as ∼3.1 V in the gate transfer IDS-VGS characteristics. This behavior is ascribed to the presence of the CdTe nanocrystals, and is indicative of the trapping and emission of electrons in the nanocrystals. The numerical simulations clearly show qualitatively the same characteristics as the experimental data and confirm the effect, showing that the change in the potential distribution across the channel, induced by both the wrapping-around gate and the drain, affects the transport characteristics of the device. The cross-sectional energy band and potential profile of the OSFG channel corresponding to the “programed (noncharged)” and “erased (charged)” operations for the device are also discussed on the basis of the numerical capacitance-voltage simulations.
Progress of LED backlights for LCDs (2008)

Abstract— Cold‐cathode fluorescent lamps (CCFLs) are being used for LCD backlighting and is currently the dominant technology for LCD backlighting. However, recent attention has been given to LEDs as light sources for LCD backlighting because of their (i) long life, (ii) low‐voltage operation, (iii) fast response time, and (iv) wide color gamut. This review article commences with the basics of LEDs as light sources and their limitations, followed by various backlight structures employing LEDs in cell phones, notebook computers, and LCD TVs. The description of the improvement in image quality on an LCD screen, stemming from the characteristics of LEDs, is also given. In conclusion, the possible rapid growth of LED backlights is outlined, thus gradually ending the domination of CCFL backlights.