gebhart/patrepeval huggingface dataset:
2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent (2014)

The ability of flavonoids to affect multiple key pathways of glucose toxicity, as well as to attenuate inflammation has been well documented. In this study, the inhibition of rat lens aldose reductase by 3,7-di-hydroxy-2-[4-(2-chloro-1,4-naphthoquinone-3-yloxy)-3-hydroxy-phenyl]-5-hydroxy-chromen-4-one (compound 1), was studied in greater detail in comparison with the parent quercetin (compound 2). The inhibition activity of 1, characterized by IC50 in low micromolar range, surpassed that of 2. Selectivity in relation to the closely related rat kidney aldehyde reductase was evaluated. At organ level in isolated rat lenses incubated in the presence of high glucose, compound 1 significantly inhibited accumulation of sorbitol in a concentration-dependent manner, which indicated that 1 was readily taken up by the eye lens cells and interfered with cytosolic aldose reductase. In addition, compound 1 provided macroscopic protection of colonic mucosa in experimental colitis in rats. At pharmacologically active concentrations, compound 1 and one of its potential metabolite 2-chloro-3-hydroxy-[1,4]-naphthoquinone (compound 3) did not affect osmotic fragility of red blood cells.
Deltoid Ligament Strain After Correction of Acquired Flatfoot Deformity by Triple Arthrodesis (2000)

Deltoid insufficiency represents a difficult surgical challenge. We have witnessed patients who have developed a valgus tibiotalar deformity following a properly positioned triple arthrodesis. To investigate whether the triple arthrodesis itself, by creating a rigid triple joint complex below the ankle, leads to increased strain of the deltoid complex, a flatfoot model was created in 8 fresh-frozen below-knee amputation specimens. Each specimen was loaded in three gait cycle (GC) positions: Heel strike (0% GC), midstance (10% GC), and heel rise (40% GC). The three components of the ground reaction force (GRF) and the tendon forces consistent with those respective positions were applied. To simulate a posterior tibial tendon insufficient state the posterior tibial tendon was not loaded. Strain at the tibiocalcaneal fibers of the superficial deltoid ligament complex was determined at each of the three foot positions. A triple arthrodesis was performed and the deltoid strains were again recorded for each position. A significant increase in the strain of the deltoid ligament was observed for only the heel rise position (p=0.007) in our cadaver model following triple arthrodesis. The results favor medializing the calcaneus following arthrodesis to protect the deltoid complex.
Zur Struktur eines kristallinen Alkalimetallcyclopentadienids (1987)

Als „Supersandwich”︁-Komplex kann das feste Kalium-trimethylsilylcyclopentadienid 1 angesehen werden. Es ist das erste basenfreie Alkalimetallcyclopentadienid, das kristallin erhalten werden konnte. 1 enthält parallel angeordnete, eindimensional-unendliche Einheiten, in denen Kaliumatome (schwarz) mit beidseitig pentahapto-gebundenen Cyclopentadienylringen abwechseln. Zwischen den Strängen bestehen schwache Wechselwirkungen.
Vortex Fluctuations in High-TcFilms: Flux Noise Spectrum and Complex Impedance (1999)

The flux noise spectrum and complex impedance for a 500 \AA{} thick YBCO film are measured and compared with predictions for two-dimensional vortex fluctuations. It is verified that the complex impedance and the flux noise spectra are proportional to each other, that the logarithm of the flux noise spectra for different temperatures has a common tangent with slope $\ensuremath{\approx}\ensuremath{-}1$, and that the amplitude of the noise decreases as ${d}^{\ensuremath{-}3}$, where $d$ is the height above the film at which the magnetic flux is measured. A crossover from normal to anomalous vortex diffusion is indicated by the measurements and is discussed in terms of a two-dimensional decoupling.
Bandgap energy bowing parameter of strained and relaxed InGaN layers (2014)

International audience
PET versus SPECT: strengths, limitations and challenges (2008)

The recent introduction of high-resolution molecular imaging technology is considered by many experts as a major breakthrough that will potentially lead to a revolutionary paradigm shift in health care and revolutionize clinical practice. This paper intends to balance the capabilities of the two major molecular imaging modalities used in nuclear medicine, namely positron emission tomography (PET) and single photon emission computed tomography (SPECT). The motivations are many-fold: (1) to gain a better understanding of the strengths and limitations of the two imaging modalities in the context of recent and ongoing developments in hardware and software design; (2) to emphasize that certain issues, historically and commonly thought as limitations of one technology, may now instead be viewed as challenges that can be addressed; (3) to point out that current state of the art PET and SPECT scanners can (greatly) benefit from improvements in innovative image reconstruction algorithms; and (4) to identify important areas of research in PET and SPECT imaging that will be instrumental to further improvements in the two modalities. Both technologies are poised to advance molecular imaging and have a direct impact on clinical and research practice to influence the future of molecular medicine.
Development of Anti-pp60 src Serum with Antigen Produced in Escherichia coli (1983)

We have purified p60(src) from bacterial recombinants which direct the synthesis of the Rous sarcoma virus transforming gene (src) product. This protein was injected into rabbits, and they produced a highly cross-reactive serum which can recognize the src protein from many different strains of Rous sarcoma virus.
CT1-2: Autoignition Characteristics of Laminar Lifted Flames in Coflow Jets(CT: Combustion, Thermal and Fluid Science,General Session Papers) (2008)

Autoignition characteristics are an important parameter in designing diesel or PCCI engines. Especially diesel spray flames are lifted from the nozzle and initial flame is formed by an autoignition phenomena. The lifted nature of diesel spray flames influences soot formation since air will be entrained into the spray core by the entrainment of air between the region of nozzle and lifted flame base. The objective of the present study is to identify the autoignition characteristics by adopting a coflow jet as a model problem. The propane jets have been injected into high temperature air and autoignition and lifted flame characteristics have been investigated experimentally. The result showed that the fuel jet in the high temperature coflow air with the initial temperature larger than 860 K was autoignited by itself without having any external ignition source. The liftoff height of the autoignited lifted flame increased nonlinearly with the fuel jet velocity, in much the similar behavior as to non-autoignited lifted flames at relatively low temperature. However, the data reduction demonstrated that the liftoff height of the autoignited flame exhibited marked difference as compared to non-autoignited cases, where the liftoff height was controlled by the balance of the propagation speed of lifted edge flame and local flow velocity. At a certain excessive jet velocity, the autoignited lifted flame had a repetitive behavior of extinction and reignition at a critical liftoff height. An analysis for this critical autoignition showed that the ignition delay time for the adiabatic case should be modified by considering heat loss to ambience. A liftoff height correlation for autoignited lifted flames has also been determined.
Effects of rare-earth elements on muskmelon(シ-ボルト2) in vitro (2001)

The paper deals with the effects of three different rare-earth elements: Ce、Y and La. The results of different concentrations of Ce and Y show that it can decrease the xanthochroism of shoots and increase the concentration of chlorophyll clearly at 50-100 mg/L; in addition, the treatment of La and IBA inhibits the formation of root of melon (シ-ボルト2). These results are significant in culture of melon in vitro with regard to the normal growth of plantlet and restrain xanthochroism.
Autoencoder Regularized Network For Driving Style Representation Learning (2017)

In this paper, we study learning generalized driving style representations from automobile GPS trip data. We propose a novel Autoencoder Regularized deep neural Network (ARNet) and a trip encoding framework trip2vec to learn drivers' driving styles directly from GPS records, by combining supervised and unsupervised feature learning in a unified architecture. Experiments on a challenging driver number estimation problem and the driver identification problem show that ARNet can learn a good generalized driving style representation: It significantly outperforms existing methods and alternative architectures by reaching the least estimation error on average (0.68, less than one driver) and the highest identification accuracy (by at least 3% improvement) compared with traditional supervised learning methods.
Expediting the Method Development and Quality Control of Reversed-Phase Liquid Chromatography Electrospray Ionization Mass Spectrometry for Pharmaceutical Analysis by Using an LC/MS Performance Test Mix (2000)

Mass spectrometry combined with liquid chromatography (LC/MS) has become an important analytical methodology in both pharmaceutical and biomolecule analyses. LC/MS, especially with reversed-phase HPLC (RP-LC), is extensively used in the separation and structural identification of pharmaceutical samples. However, many parameters have to be considered when a new LC/MS method is developed for either separation and structural analysis of unknown mixtures or quantitative analysis of a set of known compounds in an assay. The optimization of a new LC/MS method can be a time-consuming process. A novel kit-LC/MS performance test mix-composed of aspartame, cortisone, reserpine, and dioctyl phthalate has been developed to accelerate the process of establishing a new RP-LC/MS method. The LC/MS mix makes the evaluation and validation of an LC/MS method more efficient and easier. It also simplifies the quality control procedure for an LC/MS method in use.
Combined EPMA and SHRIMP Analyses of Xenotime to Interpret the Geochronological Record (2008)

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008
Secretion in Mast Cells Induced by Calcium Entrapped Within Phospholipid Vesicles (1978)

Purified mast cells secreted histamine when fused to phospholipid vesicles containing calcium but not magnesium or potassium. Microscopic observation revealed highly localized exocytotic responses involving punctate extrusion of individual granules. Calcium delivered from the vesicles to the cytoplasm is apparently a sufficient stimulus to initiate exocytosis. The results support the calcium hypothesis of stimulus-secretion coupling.
Chaotic optical phase generated by electro-optic and optoelectronic nonlinear and nonlocal delayed feedback: Successful field experiment at 10 Gb/s (2010)

We report on very recent achievements in optical chaos communications. Electro-optic phase modulation principles have been used to design a new chaos generator based on nonlinear delay dynamics. A multiple delay (both short and long) architecture allowed for an enhanced chaotic complexity, as well as a more accurate synchronization capability, over the full bandwidth of a typical 10 Gb/s binary message. Laboratory and field experiments proved the efficiency of the setup at that bit rate, demonstrating the supriority of the proposed orginal approach for practical high speed optical communications secured at the physical layer. The setup is also flexible to allow for the definition of hardware key defining the physical parameters ruling the dynamics, and which knowledge is conditional to the proper decoding. Additional variations of the setup is proposed in order to offer a higher security degree through the increase of the analogue processing occuring in the chaos generation process.
RW Aur B: a modest UX Ori-type companion of the famous primary (2020)

ABSTRACT The secondary of the famous young binary RW Aur is much less studied than the primary. To rectify this shortcoming, we present here the results of UBVRIJHK photometric, VRI polarimetric and optical spectral observations of RW Aur B. The star demonstrates chaotic brightness variations in the optical band, with irregular, short (∼1-d) dimmings with an amplitude ΔV up to 1.3 mag. The dimmings are accompanied by an increase in the linear polarization (up to 3 per cent in the I band), presumably as a result of the scattering of stellar radiation by dust in the circumstellar disc, which means that RW Aur B can be classified as a UX Ori-type star. We conclude that the observed excess emission at λ ≲ 0.45 μm and longwards of ~2 μm as well as the variability of fluxes and profiles of the H i, He i and Na i D emission lines are due to the accretion process. At the same time, emission components of Ca ii lines indicate that RW Aur B has a powerful chromosphere. Assuming solar elemental abundances, we find the following parameters for the star: Teff = 4100–4200 K, AV = 0.6 ± 0.1 (out of the dimming events), L* ≈ 0.6 ${\rm L}_\odot ,\, R_* \approx 1.5$ ${\rm R}_\odot ,\, M\approx 0.85$ M$_\odot ,\, \dot{M}_{\rm acc}\lt 5\times 10^{-9}$ M⊙ yr−1. Finally, we discuss possible reasons for the different levels of accretion activity of the RW Aur binary components and present arguments in favour of the fact that the components are gravitationally bound.
Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia. (1994)

A form of associative plasticity in Aplysia, activity-dependent neuromodulation, involves the convergence of neuronal activity and the effects of a modulatory transmitter. To investigate the role of protein synthesis in associative plasticity, we examined the effects of a biochemical analogue of activity-dependent neuromodulation on the level of incorporation of labeled amino acid into proteins. To mimic associative training, abdominal ganglia were exposed to paired treatments of a depolarizing agent, elevated potassium, and a modulatory transmitter, serotonin. The effects of elevated potassium and serotonin applied alone were also examined. At least two proteins (nos. 9 and 17) were affected in a nonadditive way by the paired procedure. Incorporation of label into protein 9 was increased by the paired procedure but was not affected by either elevated potassium or serotonin. Incorporation of label into protein 17 was significantly affected by elevated potassium or serotonin, but the effect of the paired procedure was significantly less than the summed effects of elevated potassium and serotonin applied alone. These results indicate that changes in protein synthesis may be important in the induction of associative plasticities. Amino acid sequences of two peptides derived from protein 9 were obtained. Then, a partial cDNA clone for protein 9 was obtained by performing PCR with degenerate primers corresponding to portions of the sequences of the two peptides. The sequence of protein 9 is related to sequences previously reported for a family of genes comprising the stringent starvation protein of Escherichia coli, auxin-induced proteins of plants, and glutathione S-transferases of a number of organisms.
Absolute Lymphocyte Count Recovery Predicts Superior Survival and Is Independent of the International Prognostic Index in Patients Treated with CHOP or R-CHOP Chemotherapy for Diffuse Large B Cell Lymphoma. (2005)

Abstract Absolute lymphocyte count (ALC) recovery post-autologous stem cell transplantation has been documented as an independent predictor for survival in non-Hodgkin lymphoma. The effect of ALC recovery on survival during standard CHOP or R-CHOP chemotherapy for newly diagnosed diffuse large B cell lymphoma (DLBCL) is unknown. To participate in the study, patients required to receive their full treatment with complete blood count determinations at the Mayo Clinic College of Medicine. Of 1633 DLBCL cases seen at the Mayo Clinic College of Medicine between February 1994 through August 2004, 212 consecutive DLBCL patients were eligible for the study. We study ALC recovery as a prognostic factor for progression-free survival (PFS) and overall survival (OS) in DLBCL patients treated with at least 3 cycles of CHOP or R-CHOP. 57% were male and the median age was 66 years (range: 20 – 87); 42% had elevated LDH, only 11% had a PS of 2 or higher; 58% were low stage (I or II); 88% of pts achieved a complete response. ALC was evaluated at the beginning of each treatment cycle, focusing on cycles 1–3 and the 3 month post treatment sample. ALC for each of the cycles were significantly correlated with PFS and OS, with cycle 1 ALC most significantly correlated when accounting for inherent differences based on treatment (Rx) type (i.e. CHOP vs. R-CHOP) as well as high vs. low IPI (PFS: p = 0.0012; OS: p = 0.005). Also, 74 pts achieved an ALC of at least 1,000 during all three cycles, where there was no significant relationship with this incidence and Rx type; this incidence was significantly associated with higher PFS (p = 0.0007) and OS (p = 0.0006), even when accounting for Rx type and high vs. low IPI. In the 179 pts who had 3-month post-Rx ALC data, this was also significantly associated with PFS (p = 0.002) and OS (p = 0.0009), while still accounting for Rx type and IPI status. Achievement of ALC &amp;gt;= 1,000 post-Rx was also significant for PFS (p = 0.0014) and OS (0.003). Also of note, only cycle 1 ALC was significantly different in high vs. low IPI pts (p = 0.008). In summary, these data support the hypothesis that there is a critical role of lymphocyte (immune) recovery during CHOP/R-CHOP chemotherapy in DLBCL.
Quality assessment of quiet areas: a multi-criteria approach (invited paper) (2006)

The quiet area concept has found its way to the EC environmental noise directive and the noise policy of several member states.A quiet area is generally defined as an area that is quieter than the surrounding region and has a psychological restoring effect on people visiting it.Nevertheless a clear and objective definition of what constitutes a quiet area and how its quality can be assessed is still lacking.This paper reports on work performed for the Flemish government aiming at summarizing current state of the art knowledge on quiet areas in a multi-criteria quality assessment system.A suitable soundscape for a quiet area is defined as a background that arouses a perception of silence combined with a limited number of disturbing noise events.Natural or location typical noise events are assumed to accentuate quietness rather than to jeopardize it.This view is translated to noise level based criteria at the one hand and to perception based criteria at the other hand.The role of the human listener (both the expert and the laymen enjoying the soundscape) is nevertheless prominent in the set of criteria.Quality assessment depends on the main use of the area and results in three grades of quality, thereby introducing sufficient flexibility to accommodate rural and urban quiet areas alike.
Somatostatin-induced cholestasis can be independent of portal blood flow. (1983)

Short-term experiments were performed on adult mongrel dogs (15 to 25 kg) anesthetized with sodium pentobarbital. The operative procedure included cholecystectomy, side-to-side mesocaval shunt with ligation of the portal vein, and cannulation of the common bile duct. Intravenous sodium taurocholate (500 mg/hr) was administered to prevent depletion of bile salts. Somatostatin (125 micrograms over 30 minutes) was given to six dogs after 2 hours of bile salt infusion, while six additional dogs received saline to serve as control. Bile flow decreased significantly during administration of somatostatin (206 +/- 28 to 150 +/- 21 microliters kg-1 15 min-1, P less than 0.001) and was unchanged during administration of saline (216 +/- 45 to 216 +/- 46 microliters kg-1 15 min-1). This decrease persisted for 1/2 hour after cessation of the somatostatin infusion. Bile salt outputs were similar for both groups throughout the experiment. The data demonstrate that somatostatin-induced cholestasis can be independent of portal blood flow.
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection (2009)

Identification of full-length transmitted HIV-1 genomes could be instrumental in HIV-1 pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those viruses actually responsible for productive clinical infection. We show in 12 acutely infected subjects (9 clade B and 3 clade C) that complete HIV-1 genomes of transmitted/founder viruses can be inferred by single genome amplification and sequencing of plasma virion RNA. This allowed for the molecular cloning and biological analysis of transmitted/founder viruses and a comprehensive genome-wide assessment of the genetic imprint left on the evolving virus quasispecies by a composite of host selection pressures. Transmitted viruses encoded intact canonical genes (gag-pol-vif-vpr-tat-rev-vpu-env-nef) and replicated efficiently in primary human CD4(+) T lymphocytes but much less so in monocyte-derived macrophages. Transmitted viruses were CD4 and CCR5 tropic and demonstrated concealment of coreceptor binding surfaces of the envelope bridging sheet and variable loop 3. 2 mo after infection, transmitted/founder viruses in three subjects were nearly completely replaced by viruses differing at two to five highly selected genomic loci; by 12-20 mo, viruses exhibited concentrated mutations at 17-34 discrete locations. These findings reveal viral properties associated with mucosal HIV-1 transmission and a limited set of rapidly evolving adaptive mutations driven primarily, but not exclusively, by early cytotoxic T cell responses.
Plasma Synthetic Jet for Flow Control (2010)

The necessity of having an efficient actuator to control flow has driven ONERA to develop a pioneer actuator called Plasma Synthetic Jet (PSJ). This actuator was inspired by the John Hopkins University device. It produces a high exhaust velocity jet using electrical power. This paper presents advances in characterization of its performances by using experimental and numerical approaches with the objectives of controlling flow. Then practical application of the PSJ interaction with a main flow is shown.