gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Microbiological Transformations. Part 31. Synthesis of Enantiopure Epoxides and Vicinal Diols Using Fungal Epoxide Hydrolase Mediated Hydrolysis. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interference between Sounding Reference Signal and Random Access Preamble Based on LTE Uplink (2009)

This paper discussed the interference between 3G LTE random access preamble and the SRS (Sounding Reference Signal) via multi-UE link level simulations, analyzed the performance changes of two types of signal under the influence of interference and found out the factors which leading these changes, then we summarized the way of reducing the interference.
Electro-mechanochemical approach towards the chloro sulfoximidations of allenes under solvent-free conditions in a ball mill (2022)

An electro-mechanochemical protocol for the synthesis of vinylic sulfoximines has been developed. Utilising mechanochemically strained BaTiO<sub>3</sub> nanoparticles, the catalytic active system is generated <i>in situ</i> by the reduction of copper(II) chloride. Various combinations of electron-donating and -withdrawing groups are tolerated, and the approach leads to products with difunctionalised double bonds in good to excellent yields. Attempts to add a sulfoximidoyl chloride to an alkyne proved difficult. Additions of a sulfonyl iodide to allenes and alkynes proceeded smoothly in the presence of silica gel without the need for activation by a piezoelectric material.
In Situ Synthesis of Metal Nanoparticles and Selective Naked-Eye Detection of Lead Ions from Aqueous Media (2007)

A novel one step synthesis of water soluble Au and Ag nanoparticles has been reported at room temperature using a naturally occurring bifunctional molecule, namely, gallic acid. The mechanistic details of nanoparticle formation were elucidated by carrying out control experiments using a variety of model compounds. The newly synthesized nanoparticles are extremely stable in the pH range of 4.5−5.0, due to (i) the strong electrostatic interaction of the carboxylate anion of the capping agent with the surface of the nanoparticle and (ii) a very high ζ potential (−45 mV). Under these pH conditions, it is difficult to bring nanoparticles in proximity due to strong interparticle electrostatic repulsion. However, the unique coordination behavior of Pb2+ ions (coordination number up to 12, flexible bond length and geometry) allows the formation of a stable supramolecular complex resulting in plasmon coupling and a visual color change. Because of the rigid coordination geometry, other metal cations (Ca2+, Cu2+, Cd2+, Hg2+, Mg2+, Ni2+, and Zn2+) interact only with lesser numbers of ligands, leaving the nanoparticles isolated; hence, no spectral change was observed under the experimental conditions. The ratiometric plots of the aggregated to the isolated forms indicate a high sensitivity as well as selectivity of Au and Ag nanoparticles toward Pb2+ ions. One of the significant features of the present system is its ability to detect micromolar quantities (ppm level) of Pb2+ ions in the presence of other metal cations in water. Further, we have theoretically modeled the interaction between the newly synthesized nanoparticles and the Pb2+ ion, and various optimized geometries are evaluated. On the basis of the experimental and theoretical studies, a tentative structure of the supramolecular complex leading to a strong interparticle interaction is provided.
Mechanical harvesting of citrus: an overview. (2010)

Florida is the second largest producer of orange juice in the world today, second only to Brazil. However, the production costs in Florida are nearly three times the production costs in Brazil. Reducing production costs is vital to price U.S. citrus products competitively and remain profitable in the global market. Harvesting accounts for about half of the production costs in U.S. citrus production, so mechanical harvesting could reduce costs by increasing the rate of harvest, and thereby increase profits for Florida growers. Mechanical harvesting research for citrus began in the 1950s to address the inadequate availability of labor. This research has been led by the Florida Department of Citrus, the USDA, and the University of Florida.
1155 (2014)

Cies, Jeffrey; Moore, Wayne; Dickerman, Mindy; Small, Christine; Carella, Dominick; Shea, Paul; Parker, Jason; Chopra, Arun Author Information
N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer (2008)

N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene) is a novel anti-histaminic and chemopotentiating agent that has a hormetic effect on DNA synthesis in MCF (Michigan Cancer Foundation)-7 human breast cancer cells in vitro and stimulates the growth of experimental tumors in rodents. In a prospectively randomized phase three trial (NCIC MA.19), 152 patients who were co-administered DPPE and doxorubicin survived 50% longer (P < 0.03) than 153 patients who were administered the same dose and schedule of doxorubicin alone. At clinically relevant in vitro concentrations that do not inhibit the P-glycoprotein (P-gp) pump, DPPE selectively sensitizes the cancer cells that express the multiple drug resistance phenotype, making them more susceptible to the cytotoxic effects of chemotherapeutic agents, including anthracyclines and taxanes. Based on its previously demonstrated interaction with histamine at CYP3A4, a P450 that metabolizes arachidonic acid, and its induction of high levels of prostacyclin in the gut of rodents, modulation by DPPE of the intracellular concentration of arachidonate products, such as hydroxyeicosatetraeinoic acids, implicated in increased cancer cell proliferation and metastasis, is postulated.
One Explicitly Solvable Model For The Galton-Watson Processes In the Random Environment (2020)

In this paper, we study the Galton-Watson process in the random environment for the particular case when the number of the offsprings in each generation has the fractional linear generation function with random parameters. In this case, the distribution of $N_t$, the number of particles at the moment time $t=0,1,2,\cdots$ can be calculated explicitly. We present the classification of such processes and limit theorems of two types: quenched type which is for the fixed realization of the random environment and annealed type which includes the averaging over the environment.
Colinguals among bilinguals (2008)

ABSTRACT: Discussions about intranational uses of English tend to follow the predominant theme of international uses, namely communication between people who do not have the same native language (L1). But how often do compatriots who share an L1 speak L2 English with each other? In other words, how many of a country's bilinguals are also colinguals ? If citizens are not speaking English with each other, does it make sense for their educators, literati, or politicians to claim that they have their own national variety? Is spoken discourse the prime mover that generates independent canons? That is, does abundance or lack of speech interaction in intranational contexts act as a touchstone for separating norm‐providing varieties (e.g. Indian English) from norm‐dependent varieties (e.g. so‐called “Japanese English”)? These questions serve to reinforce the tripartite classification of Kachru's model, with a focus on the similarities between the Inner and Outer Circles, counterbalancing the tendency to combine the Outer and Expanding Circles.
RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss (2018)

Precisely deciphering the molecular mechanisms of age-related memory loss is crucial to create appropriate therapeutic interventions. We have previously shown that the histone-binding protein RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss. By exploring how this protein regulates the genomic landscape of the hippocampal circuit, we find that RbAp48 controls the expression of BDNF and GPR158 proteins, both critical components of osteocalcin (OCN) signaling in the mouse hippocampus. We show that inhibition of RbAp48 in the hippocampal formation inhibits OCN's beneficial functions in cognition and causes deficits in discrimination memory. In turn, disruption of OCN/GPR158 signaling leads to the downregulation of RbAp48 protein, mimicking the discrimination memory deficits observed in the aged hippocampus. We also show that activation of the OCN/GPR158 pathway increases the expression of RbAp48 in the aged dentate gyrus and rescues age-related memory loss.
Helicos BioSciences (2008)

Helicos BioSciences Corporation is a life sciences company developing revolutionary new single molecule sequencing technology to provide the path to the US$1000 genome. True Single Molecule Sequencing (tSMS) will drive advancements in pharmacogenomics that can enable a better understanding of an individual's susceptibility to disease, develop more effective disease diagnoses and differentiate response to disease therapies. During 2007, genome-wide disease-association studies, the encylopedia of DNA elements (ENCODE) and the published genome sequence of two individuals have revealed human genome variation far more extensive than originally believed. These also demonstrated that common variations explain only a fraction of the genetic basis of disease. Therefore, the capability to understand an individual genome is critical in setting the foundation for the next great revolution in healthcare. Helicos is committed to this vision and will provide cost-effective genome sequencing and comprehensive analysis of the transcribed genome that can unlock the era of personalized healthcare.
Heat Recuperator Engineering for an ARL Liquid-Fueled Thermophotovoltaic Power Source Demonstrator (2014)

Abstract : Direct thermal-to-electrical conversion shows promise for small-scale portable power sources using logistics and multiple other fuels. Some potential technologies include thermoelectric, thermophotovoltaic (TPV), and thermionic. For these technologies, thermal efficiency is critical to achieve high energy density and thermal-to-electric conversion efficiency. Combustion can be used to convert fuel to heat a surface, but more than 50% of the thermal power of the combustor can be lost to the exhaust. As a result, heat recuperation is absolutely necessary to reclaim this lost energy. This is accomplished by heating the inlet air and fuel going into the microcombustor using the hot exhaust gases from the microcombustor. The US Army Research Laboratory (ARL) is pursuing a concept demonstration to integrate key components of a combustion-based TPV power source including a microcombustor and heat recuperator. The heat recuperator employs counter flow and microchannel heat transfer to enable high transfer rates in compact form due to a high surface area-to-volume ratio, but challenges exist with pressure drop tradeoffs and fabrication complexity. This report focuses on identifying appropriate materials and fabrication limitations for a microchannel heat recuperator preliminary design.
Identification under Random Processes (1996)

After it has been understood how common randomness of sender and receiver&amp;apos;s increases identification capacity, we study here the effect of randomness of a more general structure, namely a correlated source, when the sender has access to one marginal-source and the receivers have access to the other marginal source. The typical phenomena can be and are explained for binary symmetric correlated sources.
Adenoviral Expression of Reporter Proteins for High-Throughput Cell-Based Screening (2005)

Recombinant adenoviruses are versatile tools for gene delivery into mammalian tissue-culture cells. Adenoviruses can infect both dividing and nondividing cells, with efficiencies approaching 100%. Here we describe the use of adenoviruses to express reporter proteins in high-throughput cell-based assays.
The antidepressant tianeptine persistently modulates glutamate receptor currents of the hippocampal CA3 commissural associational synapse in chronically stressed rats (2002)

Recent hypotheses on the action of antidepressants imply a modulation of excitatory amino acid transmission. Here, the effects of long-term antidepressant application in rats with the drug tianeptine were examined at hippocampal CA3 commissural associational (c/a) glutamate receptor ion channels, employing the whole-cell patch-clamp technique. The drug's impact was tested by subjecting rats to daily restraint stress for three weeks in combination with tianeptine treatment (10 mg/kg/day). Whereas stress increased the deactivation time-constant and amplitude of the N-methyl-d-aspartate (NMDA) receptor-mediated excitatory postsynaptic currents (EPSCs), it did not affect the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate receptor-mediated EPSCs. Concomitant pharmacological treatment of stressed animals with tianeptine resulted in a normalized scaling of the amplitude ratio of NMDA receptor to AMPA/kainate receptor-mediated currents and prevented the stress-induced attenuation of NMDA-EPSCs deactivation. Both paired-pulse-facilitation and frequency-dependent plasticity remained unchanged. Both in control and stressed animals, however, tianeptine treatment strengthened the slope of the input-output relation of EPSCs. The latter was mimicked by exposing hippocampal slices in vitro with 10 micro m tianeptine, which rapidly increased the amplitudes of NMDA- and AMPA/kainate EPSCs. The enhancement of EPSCs could be blocked by the intracellular presence of the kinase inhibitor staurosporine (1 micro m), suggesting the involvement of a postsynaptic phosphorylation cascade rather then presynaptic release mechanisms at CA3 c/a synapses. These results indicate that tianeptine targets the phosphorylation-state of glutamate receptors at the CA3 c/a synapse. This novel signal transduction mechanism for tianeptine may provide a mechanistic resolution for its neuroprotective properties and, moreover, a pharmacological trajectory for its memory enhancing and/or antidepressant activity.
Micromachined Tunable Bandstop Filters for Wireless Sensor Networks (2006)

A MEMS based tunable bandstop filter is proposed for the wireless sensor networks. A tunable band-stop filter (BSF) has been designed with flat response at a selected frequency by incorporating microelectromechanical systems (MEMS) bridges. An equivalent circuit model for the tunable bandstop filter is derived and its parameters are extracted by using commercial software. High resistivity silicon substrate and MEMS surface micromachining process are employed. The measurement results for the tunable band stop filter reveals a tuning range from 19 GHz to 17.3 GHz. Additionally, low-pass-band insertion loss is found to be 1.3-2.4 db.
A Pilot Study Evaluating Presurgery Neuroanatomical Biomarkers for Postoperative Cognitive Decline After Total Knee Arthroplasty in Older Adults (2014)

Price, Catherine C.; Tanner, Jared J.; Schmalfuss, Ilona; Garvan, Cynthia Wilson; Gearen, Peter; Dickey, David; Heilman, Kenneth; McDonagh, David L.; Libon, David J.; Leonard, Christiana; Bowers, Dawn; Monk, Terri G. Author Information
Probing neural networks with t-SNE, class-specific projections and a\n guided tour (2021)

We use graphical methods to probe neural nets that classify images. Plots of\nt-SNE outputs at successive layers in a network reveal increasingly organized\narrangement of the data points. They can also reveal how a network can diminish\nor even forget about within-class structure as the data proceeds through\nlayers. We use class-specific analogues of principal components to visualize\nhow succeeding layers separate the classes. These allow us to sort images from\na given class from most typical to least typical (in the data) and they also\nserve as very useful projection coordinates for data visualization. We find\nthem especially useful when defining versions guided tours for animated data\nvisualization.\n
One Belt One Road Initiative of China: Implication for Future of Global Development (2018)

One Belt One Road (OBOR) initiative is a historical initiative which connects the people over the world and facilitates various opportunities for global peace. The main purpose of this study is to explore implication of One Belt One Road initiative for global future development. It also analyzes the reasons of origin, strategy, opportunities and challenges of OBOR initiatives on the basis of business, economic, political, social and environmental aspects. This study uses qualitative approach and secondary data particularly journal articles, conference proceedings, various documents of government, books, newspaper articles, magazine articles, and various websites of internet have been extensively used to determine the objectives. This article argues that partner countries and agencies will get economic and political benefits from these initiatives. It facilitates to connect people through road ways, air ways and water ways, coordinating policies of various governments, financial integration through cross border business, productivity and regional energy security. This study also analyzes risks and challenges associated to OBOR initiative implementation. It suggests that strong coordination among partners of OBOR is necessary to get full fruits of OBOR through supportive law, policy, rules and regulations, proper strategy implementation, transparent procurement system, sincere consideration on political, financial, environmental and social factors.
One dimensional Schrödinger operators with high potential barriers (1992)

A quantum mechanical particle moving in one-dimensional half-space under the influence of a potential V is described by the Hamiltonian (1) $$ {H_\alpha } = - \frac{{{d^2}}}{{d{x^2}}} + V\left( x \right) $$ acting on L 2 [0, ∞) with boundary conditions (2) $$ \psi \left( 0 \right)\cos \alpha + \psi '\left( 0 \right)\sin \alpha = 0\quad \alpha \in \left[ {0,2\pi } \right) $$
cAMP levels and measurement of cAMP related enzymes during yeast-to-hyphae transition in (1990)

Intracellular levels of cAMP and specific activities of adenylate cyclase, cAMP phosphodiesterase and cAMP-dependent protein kinase were measured during filamentation in the dimorphic fungus Candida albicans. Enzymatic assays were performed in permeabilized cells under conditions prevented endogenous proteolysis. The variations observed in cAMP levels were mainly accounted for by variations in the specific activities of adenylate cyclase and cAMP phosphodiesterase at different stages during germ tube formation. cAMP-dependent protein kinase, measured with kemptide as exogenous substrate, was developmental regulated. Some properties of the enzymatic activities from cell-free extracts are described.
Transmissão do sinal de insulina e acetilcolina na aorta de modelos animais e resistencia a insulina (2007)

The actions of acetylcholine on endothelium are mainly mediated through muscarinic receptors, which are members of the G protein-coupled receptor family. In the present study we show that acetylcholine induces rapid tyrosine phosphorylation and activation of Janus kinase 2 (JAK2) in rat aorta. Upon JAK2 activation, tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) is detected. In addition, acetylcholine induces JAK2/IRS-1 and IRS-1/phosphatidylinositol (PI) 3-kinase associations, downstream activation of Akt/protein kinase B, endothelial cell-nitric oxide synthase (eNOS), and extracellular signal-regulated kinase (ERK1/2). The pharmacological blockade of JAK2 or PI 3-kinase reduced acetylcholine-stimulated eNOS phosphorylation, NOS activity and aorta relaxation. These data indicate a new signal transduction pathway for IRS-1/PI 3-kinase/Akt/eNOS activation and ERK1/2 by means of JAK2 tyrosine phosphorylation stimulated by acetylcholine in vessels. Moreover, we demonstrate that, in aorta of obese rats (high-fat diet), there is an impairment in insulin-and acetylcholinestimulated IRS-1/PI 3-kinase pathway, leading to reduced activation with lower protein levels of eNOS associated with a hyperactivated ERK/MAP kinase pathway. These results suggest that in aorta of obese rats, there is not only insulin resistance, but also acetylcholine resistance, probably mediated by a common signaling pathway that controls the activity and the protein levels of eNOS.
Effect of Traumatic Brain Injury on Mouse Spatial and Nonspatial Learning in the Barnes Circular Maze (1998)

Controlled cortical impact (CCI) is a relatively new model of traumatic brain injury in the mouse, which, in combination with behavioral and histological methods, has potential for elucidating underlying mechanisms of neurodegeneration using genetically altered animals. Previously, we have demonstrated impaired spatial learning in a water maze task following CCI injury at a moderate level. There are many difficulties associated with this task, however, such as stress, physical demand, and the multiple trials over days required for satisfactory training. As a potential alternative to the water maze, we adapted the Barnes circular maze to our mouse model and assessed spatial/nonspatial learning following injury. Mice were trained to locate a dark tunnel, hidden beneath one of 40 holes positioned around the perimeter of a large, flat, plastic disk, brightly illuminated by four overhead halogen lamps. Sham-operated animals rapidly acquired this task, exhibiting reduced latency to find the tunnel and a more efficient search strategy as compared with injured mice. This difference was not due to visuomotor deficits, as all mice performed equally well in a cued version of the same task. These results demonstrate spatial learning impairment following CCI injury in a task that offers an efficient alternative to the water maze.
Planar printed monopole antennas for ultra-wideband/multi-band wireless systems (2011)

An ultra-wideband (UWB) antenna with band rejection of WLAN/WiMAX systems and a tri-band antenna for WLAN/WiMAX applications are, respectively, proposed by the band-rejected design of the coplanar waveguide (CPW) fed circular monopole antenna. In order to notch the frequency bands covered by WLAN and WiMAX, two pieces of bent slotline are loaded at the patch bottom of the conventional UWB antenna. The proposed antenna has a good UWB characteristic with the measured notched frequency bands of 3.29-4GHz and 5.1-6GHz. In the new design of the tri-band monopole antenna, the slotline, resonant stub and radial slot are adopted to reject and control the frequency band of the conventional UWB antenna. This new tri-band monopole antenna renders the measured frequency bands of 2.25-2.8GHz, 3.3-3.8GHz and 5.1-5.9GHz for WLAN/WiMAX applications, and has a good band rejected characteristic in the other bands.
High performance polarization-independent WDM filtering using an InP reflective arrayed waveguide grating (2002)

Summary form only given. We report a high-performance polarization-independent InP arrayed waveguide grating (AWG) filter employing a compact reflective geometry. Here, we show that square-core AWGs may be realized in a reflection geometry, and still provide high quality filtering. Successful use of a reflective AWG geometry will permit advanced AWG-based components to be made with smaller die-sizes.