gebhart/patrepeval huggingface dataset:
Israel: coronary and structural heart interventions from 2010 to 2015 (2017)

The Israel Heart Society is a member of the European Society of Cardiology, and the Israeli Working Group of Interventional Cardiology is an active participant in EAPCI. The aim of this manuscript is to provide a snapshot of cardiac interventions performed in the State of Israel during the period 2010-2015. Data for this manuscript were collected via collaboration with the National Diseases Registries Unit of the Israel Center for Disease Control. During the survey period, the Israeli population increased by 7% but only one additional hospital with an active cardiac catheterisation laboratory was opened. The vast majority of the percutaneous procedures are performed in public hospital settings. Total coronary angiography procedures remained stable throughout the survey period, and the percentage of PCI out of total coronary angiography procedures remained approximately 50% throughout the survey period. More than 90% of the PCI procedures were performed using stent deployment, and the use of drug-eluting stents increased significantly during the survey period from 46% in 2010 to 92% in 2015. The number of TAVI procedures increased dramatically, by more than sixfold, from 130 procedures in 2010 to 851 procedures in 2015 (with 130 implants/million population at Q4 of 2015). The vast majority of interventional cardiology procedures are funded by the governmental healthcare providers, and all the citizens of the country have access to the most advanced cardiac interventions. If corrected for the increase in the population, the volumes of coronary interventions are decreasing throughout the country. However, structural heart disease interventions, and specifically valvular interventions, are growing rapidly and this trend is expected to continue in the near future.
Longevity of Laboratory-Reared Adult Female Anopheles Stephensiin Four Types of Cylinders1 (1970)

Anopheles Stephensi Liston has proved to be a valuable laboratory vector of human and simian malaria. Studies on the sporogonous cycle may require large numbers of experimental groups which must be maintained for 20–30 days after infection. It was found that this objective could not be attained when the adults were housed in smooth, clear-lucite cylinders which have been routinely used for other species of mosquitoes. Accordingly, longevity studies were conducted with 4 types of cylinders, maintaining the adults therein for 30 days on raisin juice at a dry-bulb temperature of 26.5°C and 75±5% RH.
Infrared laser post-ionization of large biomolecules from an IR-MALD(I) plume (2004)

A two-infrared laser desorption/ionization method is described. A first laser, which was either an Er:YAG laser or an optical parametric oscillator (OPO), served for ablation/vaporization of small volumes of analyte/matrix sample at fluences below the ion detection threshold for direct matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). A second IR-laser, whose beam intersected the expanding ablation plume at a variable distance and time delay, was used to generate biomolecular ions out of the matrix-assisted laser desorption (MALD) plume. Either one of the two above lasers or an Er:YSGG laser was used for post-ionization. Glycerol was used as IR-MALDI matrix, and mass spectra of peptides, proteins, as well as nucleic acids, some of which in excess of 10(5) u in molecular weight, were recorded with a time-of-flight mass spectrometer. A mass spectrum of cytochrome c from a water ice matrix is also presented. The MALD plume expansion was investigated by varying the position of the post-ionization laser beam above the glycerol sample surface and its delay time relative to the desorption laser. Comparison between the OPO (pulse duration, tau(L) = 6 ns) and the Er:YAG laser (tau(L) approximately 120 ns) as primary excitation laser demonstrates a significant effect of the laser pulse duration on the MALD process.
Nonlinear precession of the polarization ellipse in resonant atomic media: two-level systems and Rb (2000)

Summary form only given. Self-rotation (SR) of the polarization ellipse upon propagation through a nonlinear medium was among the first nonlinear optics phenomena observed. SR in resonant atomic vapors has been the subject of several theoretical and experimental studies. We describe SR in two-level F/spl rarr/F' systems (F, F' are the total angular momenta of the lower and the upper state) and present experiments and theoretical interpretation (based on density matrix calculations) of SR on the Rb D/sub 1,2/ lines.
Magnetic Tracker Calibration for Improved Augmented Reality Registration (1997)

We apply a look-up table technique to calibrate both position and orientation readings from a magnetic tracker for use in virtual environments within a defined working volume. In a test volume of 2.4 cubic meters, the method reduced the tracker's average position error by 79% and its average orientation error by 40%. We test the correction table against the tracker's performance outdoors (a metal-poor environment) and show that readings taken in our lab and corrected by our method exhibit less error than uncorrected readings taken outdoors. We demonstrate that such reduction in position error visibly improves registration in an augmented reality system, whereas the (lesser) reduction in orientation error does not visibly improve registration. We show that the model we used for the orientation error function was incorrect, preventing our method from achieving better correction of orientation error, We discuss future directions for correction of orientation error.
Technical Innovation: Gasless Laparoscopic Hepatectomy Using Self-Designed Abdominal Lifting System (2009)

In this article, we describe a new technique for performing a laparoscopic-assisted hepatectomy, using a self-designed abdominal wall-lifting systems. We used this system for 5 patients; 2 were left lateral segmentectomy, 1 was S6 segmentectomy, and 1 was S8 wedge resection, and the other was an extended left hepatectomy. This procedure can minimize the length of the wound, while avoiding the lethal complications associated with the pneumoperitonium. This device and technique can also provide a bridge for young or less-experienced surgeons to be familiar with advanced laparoscopic surgery from open surgery. Also, the patients under such an operation were found to have fast postoperation recovery and short hospital stay.
Image quality--critical to PACS (1993)

Consistent image presentation is crucial to the diagnostic and commercial success of medical imaging networks. The issues and factors involved with insuring the integrity of the tonal presentation in a networked environment are discussed, and a solution is proposed incorporating the ACR-NEMA 3.0 data structure. An example of a representative system configuration is given.
Phigaro: high-throughput prophage sequence annotation (2020)

Supplementary data are available at Bioinformatics online.
National Laboratory Planning: Developing Sustainable Biocontainment Laboratories in Limited Resource Areas (2016)

Strategic laboratory planning in limited resource areas is essential for addressing global health security issues. Establishing a national reference laboratory, especially one with BSL-3 or -4 biocontainment facilities, requires a heavy investment of resources, a multisectoral approach, and commitments from multiple stakeholders. We make the case for donor organizations and recipient partners to develop a comprehensive laboratory operations roadmap that addresses factors such as mission and roles, engaging national and political support, securing financial support, defining stakeholder involvement, fostering partnerships, and building trust. Successful development occurred with projects in African countries and in Azerbaijan, where strong leadership and a clear management framework have been key to success. A clearly identified and agreed management framework facilitate identifying the responsibility for developing laboratory capabilities and support services, including biosafety and biosecurity, quality assurance, equipment maintenance, supply chain establishment, staff certification and training, retention of human resources, and sustainable operating revenue. These capabilities and support services pose rate-limiting yet necessary challenges. Laboratory capabilities depend on mission and role, as determined by all stakeholders, and demonstrate the need for relevant metrics to monitor the success of the laboratory, including support for internal and external audits. Our analysis concludes that alternative frameworks for success exist for developing and implementing capabilities at regional and national levels in limited resource areas. Thus, achieving a balance for standardizing practices between local procedures and accepted international standards is a prerequisite for integrating new facilities into a country's existing public health infrastructure and into the overall international scientific community.
PTEN, Akt, and GSK3β signalling in rat primary cortical neuronal cultures following tumor necrosis factor‐α and trans‐4‐hydroxy‐2‐nonenal treatments (2006)

PTEN is a dual phosphatase that negatively regulates the phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway important for cell survival. We determined effects of the inflammation and oxidative stresses of tumor necrosis factor-alpha (TNFalpha) and trans-4-hydroxy-2-nonenal (HNE), respectively, on PTEN, Akt, and GSK3beta signalling in rat primary cortical neurons. The inhibitors bisperoxovanadium [bpV(Pic)] and LY294002 were also used to determine PTEN and PI3K involvement in TNFalpha and HNE modulation of neuronal cell death. PTEN inhibition with bpV(Pic) alone did not affect Ser(473)Akt or Ser(9)GSK3beta phosphorylation. Instead, effects of this inhibitor were manifest when it was used together with TNFalpha and to a lesser extent with HNE. TNFalpha together with PTEN inhibition increased phosphorylation of Ser(473)Akt and Ser(9)GSK3beta. TNFalpha and HNE both gave decreased numbers of viable and increased numbers of early apoptotic neurons. PTEN inhibition partially reversed the toxic effect of TNFalpha as shown by an increased number of viable and a decreased number of early apoptotic neurons. All effects were reversed by PI3K inhibition. HNE together with inhibition of PTEN gave increased Ser(473)Akt but not Ser(9)GSK3beta phosphorylation and no effects on the number of viable or early apoptotic cells. In conclusion, PTEN inhibition gives a mild reversal of TNFalpha- but not HNE-induced cell death via the PI3K pathway.
Pelvic Organ Prolapse (2020)

Pelvic organ prolapse (POP) is the herniation of the genital tract through the vagina. Risk factors for POP include increasing parity, advancing age, obesity, and hysterectomy, chronic constipation, heavy lifting jobs, as well as genetic background. This chapter discusses the background of the disease, including the incidence/prevalence, economic impact, etiology, and pathology/pathogenesis of POP. It provides information on the screening, primary prevention and secondary prevention of the disease. The chapter describes the typical presentation and clinical diagnosis of POP. It discusses treatment options, including treatment rationale and complications, and prognosis for POP. The chapter also provides information on special populations, such as pregnant women, elderly women, and obese women, who are at the risk of POP. Conservative treatments include vaginal pessaries and pelvic floor muscle exercises. Surgical managements are offered to women with symptomatic POP, who have failed or declined conservative management.
AB005: Anatomical and optical changes during the development of myopia (2017)

: Myopia is not only a serious problem in Hong Kong, but is a rising global phenomena. It is predicted that by 2050, 49.8% of the world’s population will have myopia with approximately 900 million people developing high myopia. High myopia is associated with the development of staphyloma, lacquer cracks and myopic macular degeneration, and is a leading cause of profound blindness. Understanding how high myopia develops and its relationship to myopia susceptibility is critical for the development of appropriate treatments. Animal models have provided insight into the possible underlying mechanisms, and are useful for testing potential treatment options. We have developed a mammalian model of myopia using the guinea pig in which eye growth is manipulated though classical aberrant visual input. This talk will review some of the major insights gained from such models and present new data on the anatomical and optical changes associated with the progression of myopia. This includes the effect of blur exposure on the optical development of the eye, the transition between myopia and high myopia development, and the potential impact of scleral treatments for high myopia.
The chemical energetics of muscle contraction I. Activation heat, heat of shortening and ATP utilization for activation-relaxation processes (1969)

Abstract Measurements have been made of the changes in adenosine triphosphate and inorganic phosphate associated with activation and shortening in isolated sartorius muscles of Rana pipiens at 0°C. The muscles were pretreated with 2, 4-dinitrofluorobenzene to inhibit adenosine triphosphate: creatine phosphotransferase. When unloaded muscles were stimu­lated electrically, allowed to shorten fully and stay shortened during further stimulation, it was found that the usage of adenosine triphosphate (and production of inorganic phosphate) per pulse became less and less at greater rates of stimulation. The adenosine triphosphate usage per second reached a plateau and continued for a short while after the last pulse. This adenosine triphosphate is presumably used almost entirely for pumping calcium. Very little adenosine triphosphate was used per pulse by muscles in hypertonic solutions. These muscles passed normal action potentials but did not shorten or develop tension. Muscles which were re-extended after each of a series of almost completely unloaded shortenings had been completed used only the small amount of extra adenosine triphosphate needed for the little extra work done. Even the total breakdown of adenosine triphosphate was much too small to account for the heat of shortening, if this heat is assumed to be degraded free energy from adenosine triphosphate. Experiments were carried out according to Professor A. V. Hill’s ‘Further challenge to biochemists’. They showed that less adenosine triphosphate was used in the first 200 ms by a lightly loaded isotonic muscle than by an isometric muscle. Thus the heat of shortening, which is observed only while the muscle is shortening but not in the whole contraction-relaxation cycle, cannot be degraded free energy from adenosine triphosphate.
Low-density granular fill for damping structural vibrations (1995)

Granular materials have been used for many years to damp structural vibrations. Often these treatments incorporate sand or lead shot. Both are heavy and provide some of their damping effect through mass loading. This paper discusses the damping properties of a low-density granular material, 3M glass microbubbles (tradename Scothlite). A paste was made using water and Scothlite and placed in an aluminum free-free beam. Resonant peaks of the beam were reduced by 10 dB, and in some cases more. The specific gravity of the Scothlite is about 0.1, so mass loading effects cannot account for the damping. Further, glass is not normally considered to be highly viscoelastic at room temperature. Rather, the attenuation mechanism is thought to be activated by the low bulk sound speed of the granular fill. With a low sound speed, the wavelength is short, and incipient attenuation in the fill becomes important. The mechanism is a combination of four possibilities: (1) small but finite intrinsic material attenuation, (2) frictional losses between rubbing grains, (3) nonlinear hystere viscous losses of the fluid flow between grains. [Research sponsored by ARPA/ONR.] a)E-mail: fricke@mit.edu
A Successful Polymer Treatment For Water Coning Abatement in Gas Storage Reservoir (2001)

Abstract A polymer treatment has been successfully applied in a Gaz-de-France gas storage well facing excessive water production problems limiting its maximum gas flow rate. The well was located in a limestone reservoir submitted to an active bottom aquifer. To reduce the risk of well impairment while enhancing the efficiency to fight water coning, the polymer slug was injected into the half of the open interval located at the bottom of the reservoir. A study consisting of laboratory core tests and numerical simulations aimed at sizing polymer slug and concentration before performing the treatment. The level of water permeability reduction to reach was fulfilled with single polymer adsorption without the need of adding cross-linker. After a period of two years where no significant effect on water production occurred, the well progressively improved its performances while water production remained at the same level in neighbour wells. After ten years of survey, the well, which was one of the worse of the storage, became one of the best, capable to sustain high levels of gas production with low water. The delay in well response is probably due to the high water saturation level of the reservoir surrounding the wellbore consecutive to the injection of the polymer slug. The results show that the technique, while easy to handle, gives remarkably efficient long-lasting effect.
Single chain FV constructs of anti-ganglioside GD2 antibodies for radioimaging and radioimmumotheraphy. Progress report (1993)

For the past several years, we have studied the anti-G{sub D2} murine monoclonal antibody, 3F8, in radiolabeled form, for diagnosis and therapy of neuroblastoma. The targeting properties of this antibody/antigen system are exceptional, with uptakes consistently in the highest range of reported results for in vivo human studies. The radioiodinated antibody 3F8 is now used by us as our criteria for diagnosis and staging of advanced neuroblastoma. This antibody is showing considerable promise also in our Phase I trials in Stage 4 neuroblastoma, and major responses are being seen at current dose level, with manageable marrow toxicity, but no limiting organ toxicity.
Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer (2023)

Notch signaling is a conserved signaling pathway that participates in many aspects of mammary gland development and homeostasis, and has extensively been associated with breast tumorigenesis. Here, to unravel the as yet debated role of Notch3 in breast cancer development, we investigated its expression in human breast cancer samples and effects of its loss in mice. Notch3 expression was very weak in breast cancer cells and was associated with good patient prognosis. Interestingly, its expression was very strong in stromal cells of these patients, though this had no prognostic value. Mechanistically, we demonstrated that Notch3 prevents tumor initiation via HeyL-mediated inhibition of Mybl2, an important regulator of cell cycle. In the mammary glands of Notch3-deficient mice, we observed accelerated tumor initiation and proliferation in a MMTV-Neu model. Notch3-null tumors were enriched in Mybl2 mRNA signature and protein expression. Hence, our study reinforces the anti-tumoral role of Notch3 in breast tumorigenesis.
Supernovae in Low‐Redshift Galaxy Clusters: Observations by the Wise Observatory Optical Transient Search (WOOTS) (2008)

We describe the Wise Observatory Optical Transient Search (WOOTS), a survey for supernovae (SNe) and other variable and transient objects in the fields of redshift 0.06-0.2 Abell galaxy clusters. We present the survey design and data-analysis procedures, and our object detection and follow-up strategies. We have obtained follow-up spectroscopy for all viable SN candidates, and present the resulting SN sample here. Out of the 12 SNe we have discovered, seven are associated with our target clusters while five are foreground or background field events. All but one of the SNe (a foreground field event) are Type Ia SNe. Our non-cluster SN sample is uniquely complete, since all SN candidates have been either spectroscopically confirmed or ruled out. This allows us to estimate that flux-limited surveys similar to WOOTS would be dominated (~80%) by SNe Ia. Our spectroscopic follow-up observations also elucidate the difficulty in distinguishing active galactic nuclei from SNe. In separate papers we use the WOOTS sample to derive the SN rate in clusters for this redshift range, and to measure the fraction of intergalactic cluster SNe. We also briefly report here on some quasars and asteroids discovered by WOOTS.
Computer-assisted Navigation in Hip Resurfacing Arthroplasty: A Case Study utilizing the ReCap Femoral Resurfacing System. (2019)

These findings are the first to describe the use of navigation with the ReCap system and provide encouraging results for further clinical evaluation.
Persistence of the efficacy of doramectin against Ostertagia ostertagi and Cooperia oncophora in cattle (1998)

The persistence of the efficacy of doramectin injectable against Ostertagia ostertagi and Cooperia oncophora was evaluated in two studies in calves. In both, the calves were allocated to six groups of six. Calves in the first control group (C1) and first treated group (T1) received a daily infection of 200 L3 of O ostertagi and 200 L3 of C oncophora; the calves in groups C2 and T2 received a daily infection of 1000 L3 of each species, and groups C3 and T3 received 10,000 L3 of each species per day. The calves in the three treated groups each received 0.2 mg/kg doramectin injectable on day 0. In the first study, the calves were infected for 21 days with Cooperia and for 28 days with Ostertagia, and they were slaughtered on day 33. In the second study, the calves were infected for 21 days with both species, the infections with Cooperia and Ostertagia starting from eight and 15 days, respectively, after the treatment, and the animals were slaughtered on day 40. The calculation of the persistence of the activity of doramectin was based on its efficacy against the different developmental and adult stages of the two parasites. The data from both studies indicated that the efficacy of doramectin against Ostertagia persisted for at least five weeks, but no conclusions could be drawn about the effect of the size of the infective doses on the persistence of the activity. In contrast, the Cooperia worm counts from the second study suggested that the efficacy of doramectin against Cooperia persisted for at least four weeks when the calves were exposed to a low or moderate infection level, whereas at the highest infection level it persisted for between three and four weeks.