gebhart/patrepeval huggingface dataset:
Regulatory Interaction between Arylhydrocarbon Receptor and SIM1, Two Basic Helix-Loop-Helix PAS Proteins Involved in the Control of Food Intake (2004)

The basic helix-loop-helix PAS (bHLH-PAS) transcription factors SIM1 and arylhydrocarbon receptor (AHR) are involved in the control of feeding behavior. Sim1 haploinsufficiency causes hyperphagia in mice and humans, most likely by perturbing the hypothalamus function. The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a ligand of AHR, causes severe anorexia, which also appears to be of central origin. Both SIM1 and AHR require heterodimerization either with ARNT or ARNT2 to function. Here, we characterize the promoter for Sim1 and show that a consensus AHR-ARNT/2 binding site positively regulates its activity in the context of transfection experiments in Neuro-2A cells. A gel shift assay indicated that AHR-ARNT/2 can bind its putative site in the Sim1 promoter. Overexpression of Arnt, Arnt2, or Ahr increased the activity of a reporter construct containing the Sim1 promoter by 1.8-, 1.5-, and 2.2-fold, respectively, but failed to do so when the AHR-ARNT/2 binding site was mutated. Similarly, TCDD increased the activity of the reporter construct by 1.8-fold but not that of its mutated version. Finally, we found that TCDD increased Sim1 expression in Neuro-2A cells and in mouse kidney and hypothalamus by 4-, 3-, and 2-fold, respectively. We conclude that Sim1 expression is regulated by AHR-ARNT/2. This result raises the possibility that Sim1 mediates the effect of TCDD on feeding and points to a complex network of regulatory interactions between bHLH-PAS proteins.
ID Based Cryptography for Cloud Data Storage (2013)

This paper addresses the security issues of storing sensitive data in a cloud storage service and the need for users to trust the commercial cloud providers. It proposes a cryptographic scheme for cloud storage, based on an original usage of ID-Based Cryptography. Our solution has several advantages. First, it provides secrecy for encrypted data which are stored in public servers. Second, it offers controlled data access and sharing among users, so that unauthorized users or untrusted servers cannot access or search over data without client's authorization.
Extraction of bioactive principles from Mucuna pruriens seeds. (2007)

Mucuna pruriens (L.) DC. Syn. M. prurita Hook. (Papilionaceae) is used in male impotency, as aphrodisiac, in sexual debility, and as nervine tonic. It also possesses anti-parkinson property, possibly due to the presence of L-DOPA. In the present study, attempts were made to develop the suitable method(s) for extraction of L-DOPA/other active components from the seeds using different solvents. The various extracts were also screened for their neuroprotective and antioxidant activities. In addition, TLC and HPLC fingerprinting of the extracts for amino acid components were also developed for preliminary and sophisticated analysis. The L-DOPA could be obtained in good yield on extraction with EtOH-H2O mixture (1:1) using ascorbic acid as protector. Interestingly, n-propanol extract, which contained negligible amount of L-DOPA, had shown significant neuroprotective activity, suggesting that some components, other than L-DOPA, might also be responsible for anti-Parkinson property of seeds. The extract (MW-0100) containing mainly amino acids and water-ethanol extract (1:1) (MWEL-1299) showed promising antioxidant activity (EC50 = 2.5 microg) against DPPH radicals. MWEL-1299 also exhibited encouraging results against 1-methyl-4-phenylpyridinium ion (MPP+) toxicity. The TLC fingerprinting may be used to authenticate the plant material in herbal industry.
Learning Representative Features for Robot Topological Localization (2013)

This paper proposes a new method for mobile robots to recognize places with the use of a single camera and natural landmarks. In the learning stage, the robot is manually guided along a path. Video sequences are captured with a front-facing camera. To reduce the perceptual alias of visual features, which are easily confused, we propose a modified visual feature descriptor which combines the dominant hue colour information with the local texture. A Location Features Vocabulary Model (LVFM) is established for each individual location using an unsupervised learning algorithm. During the course of travelling, the robot employs each detected interest point to vote for the most likely place. The spatial relationships between the locations, modelled by the Hidden Markov Model (HMM), are exploited to increase the robustness of location recognition in cases of dynamic change or visual similarity. The proposed descriptors are compared with several state-of-the-art descriptors including SIFT, colour SIFT, GLOH and SURF. Experiments show that both the LVFM based on the dominant Hue-SIFT feature and the spatial relationships between the locations contribute considerably to the high recognition rate.
Spectral target classification with SOSTAR-X (2008)

The SOSTAR-X project has developed a demonstrator dedicated to the surveillance of both fixed and moving targets on large coverage areas, target activity analysis on dedicated areas and classification on designated targets. In this project, The Netherlands contribution has been in the areas of Spectral Classification (SPC mode), SAR SPOT mode autofocus, antenna harness, and ground target coordination during the flight campaign in the Netherlands. This paper focuses on the topic of Spectral Classification. The so-called SPC mode is a dedicated mode activated on a designated target, which classifies the target as wheeled, tracked (treaded), rotary wing, or rotating antenna. This is achieved by producing a high resolution Doppler profile, containing modulations caused by moving parts of the vehicle, and classifying on the basis of this profile. The SPC mode has been designed, implemented in the sensor and the Radar Processing Unit, and validated during extensive flight trials, in the Netherlands, Germany, and France.
Biphotonic Microscopy for in vitro, in vivo tissue phenotyping and cell tracking (2017)

Biphotonic Microscopy for [i]in vitro[/i], [i]in vivo[/i] tissue phenotyping and cell tracking. Gen2bio2017
Independent, voluntary control of extra robotic limbs (2017)

Most of the wearable robots today assist their users by acting in parallel or in series to their natural limbs. We propose a different approach to wearable robotics, consisting of devices that provide users with additional, independent robotic limbs. We present a wearable robot prototype that can achieve these goals with an extremely light weight apparatus. In order to control additional robotic limbs as if they were part of the user's body, we need voluntary signals that are independent of natural limb motions and comfortable to measure. One suitable solution - explored in this study - is the use of muscle activation signals generated by the torso. We hypothesize that a human is competent to move the extra limbs voluntarily and independently without interfering with the natural arms and legs. We developed a wearable suit to measure these signals, and we tested three possible real-time control strategies linking torso muscle contraction to the motions of two simulated extra limbs. The experimental data show that the velocity control strategy yields the highest motion accuracy, minimum muscular effort, maximum independence from the natural limbs and the fastest learning rate. This control strategy has then been applied to the control of the physical robot prototype, worn by human subjects. All of the subjects achieved accurate (normalized tracking error <; 0.5), independent (normalized natural arm motions <; 0.15) control of the extra limbs.
The Service Imperative (2018)

This chapter suggests that the shift from products to services, if it is to be fully leveraged as a driving force, requires a parallel transformation in the way organizations are conceptualized, structured, and, most importantly, managed. It argues that organizations that place a premium on the design, development, and delivery of services are as different from traditional industrial organizations as the factory is from the farm. Harvard Business School professor Theodore Levitt agrees that the service and nonservice distinction becomes less and less meaningful as our understanding of service increases. The tendency in Japan is, as it has been, to equate service with servitude and face-to-face attention rather than with customer-centered management. Housekeeping services for females, military conscription for males, and street vending for both sexes are the primary type of service activity in traditional societies. Industrial services are really organized groups of highly skilled specialists.
Neighbourhood crime and anti-social behaviour: the Audit Commission report (2006)

This article explores the findings of the recent Audit Commission report. Crime and disorder reduction partnerships (CDRPs) need a sound understanding of what makes people safe in a particular area. The report identifies some positive achievements and ways in which agencies can improve further in the light of new policy developments in neighbourhood policing and community safety.
The Dispersion of Nearest-Neighbor Decoding for Additive Non-Gaussian Channels (2016)

We study the second-order asymptotics of information transmission using random Gaussian codebooks and nearest neighbor decoding over a power-limited stationary memoryless additive non-Gaussian noise channel. We show that the dispersion term depends on the non-Gaussian noise only through its second and fourth moments, thus complementing the capacity result (Lapidoth, 1996), which depends only on the second moment. Furthermore, we characterize the second-order asymptotics of point-to-point codes over K-sender interference networks with non-Gaussian additive noise. Specifically, we assume that each user's codebook is Gaussian and that NN decoding is employed, i.e., that interference from the K -1 unintended users (Gaussian interfering signals) is treated as noise at each decoder. We show that while the first-order term in the asymptotic expansion of the maximum number of messages depends on the power of the interfering codewords only through their sum, this does not hold for the second-order term.
Determination of partitioning values of parathion-methyl and related compounds (1970)

Hansch and Fujita have developed a structure-activity relationship based on partition coefficients in which they use a water-octanol system for determining π-values. Beroza and his co-workers have determined partitioning values (p-values) for many pesticides using a simple method and equation for conversion from p-value into partition coefficient. In this paper the relationship between p-value and π-value is established and the p-values of some new organophosphorus compounds are reported. The p-value determined by gas chromatography is compared with π-values derived from radiotracer methods; the advantages of determining p-values by Beroza's method over the radiotracer method are emphasised.
Early hours of treatment in a neonate nine-banded armadillo (dasypus novemcinctus) rescued from illegal trafficking in Ecuador (2009)

This paper presents the case of a baby nine-banded armadillo (Dasypus novemcinctus), which was rescued from illegal wildlife trafficking in the province of Pastaza (Ecuador) and was delivered to the Center for Wildlife Rescue Flor de la Amazonia Wayra Urku (Km.35 via Arajuno, Puyo-Pastaza, Ecuador). This animal had at the time of rescue, severe hypothermia and dehydration, was treated and later was introduced to a change in diet ideal for raising it. In this review we discuss the different ways to approach the case and the treatment chosen to avoid premature death of the animal. It is believed that proper protocol was chosen to correct the initial unstable state and start hand rearing.
Considering processing cost in network simulations (2003)

In many network simulations and models the cost of processing a packet is considered negligible or overly simplified. The functionality of routers is steadily increasing and complex processing of packet payloads is being implemented (deep packet classification, encryption, content transcoding). We show two examples where processing cost can contribute to a significant portion of the overall packet delay. To enable a more precise consideration of processing delay, we present a tool called NPEST (Network Processing Estimator). NPEST is a framework on top of which packet processing functionality can be implemented and simulated using an actual processor simulator. NPEST can be programmed in C and greatly simplifies the implementation and simulation process as compared to using network processor simulators. The results derived from NPEST can either be used directly or be aggregated to processing statistics for network simulations. We present such results for two prototype applications: IP forwarding and IP security. We also show a comparison between the results obtained from NPEST and an Intel IXP1200 network processor.
The effect of the barrier thickness on DC and RF performances of AlGaN/GaN HEMTs on silicon (2023)

Abstract In this study, the effect of barrier thickness on the DC and RF performances of AlGaN/GaN high-electron mobility transistors (HEMTs) on silicon for millimeter wave applications is experimentally investigated. GaN HEMT devices with different barrier thicknesses were fabricated and characterized. While the device with the thinnest barrier exhibited the highest extrinsic transconductance (g m ) resulting from the shortest gate-to-channel distance, such configuration suffered from the lowest unit current-gain cut-off frequency (f T ) due to the increase of the total gate capacitance. Moreover, degradation in the output power was observed for devices with thinner barriers. Such degradation was related to the severe knee walkout as evidenced from drain-lag characterization.
Phase I/IIclinical trial of local GM-CSF application in patients with cervical HPV-associated low grade squamous intraepithelial lesions (2007)

Background: Quantitative and functional alterations of professional antigen-presenting cells (APC) in SIL suggest that these lesions may have a diminished capacity to capture viral antigens. Moreover, GM-CSF (whose production is decreased in HPV-transformed keratinocytes) is an essential factor for the migration of APC in cervical (pre)neoplastic lesions formed in vitro and transplanted in vivo on mouse. In this study we performed a phase I/II clinical trial in order to determine whether a local application of GM-CSF on cervical low-grade squamous intraepithelial lesions (LSIL) might increase the recruitment of APC into the epithelium and indirectly the viral antigen presentation to the immune system. Methods: Fifteen patients with LSIL (10 GM-CSF and 5 placebo) were enrolled in this study. Patients received 4 GM-CSF applications (or placebo gel) and were followed during 6-7 months. APC infiltration was quantified by immunostaining with anti-CD1a mAb. Cellular immune response was evaluated by using an IFN-gamma intracellular staining on PBMC stimulated in vitro with the E7 HPV16 protein and L1 HPV16 Virus-like particles (VLP). Hybrid capture was performed to semi-quantify the viral DNA in cervical brush specimens. Results: GM-CSF applications were well tolerated in all patients. No difference in the cytological/histological and viral parameters assessed at 2 and 6 months after the last application was observed between the GM-CSF and the placebo group. An increased number of CD1a+ APC was observed in 6/10 patients treated by GM-CSF compared to 1/5 patient in the placebo group. There was an increased immune response against HPV in the GM-CSF group showed by NK and T cells producing IFN-gamma.
Parathyroid Hormone and Parathyroid Hormone-related Peptide Activate the Na+/H+ Exchanger NHE-1 Isoform in Osteoblastic Cells (UMR-106) via a cAMP-dependent Pathway (1995)

Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHRP) regulate Na+/H+ exchanger activity in osteoblastic cells, although the signaling components involved are not precisely defined. Since these peptide hormones can stimulate production of diverse second messengers (i.e. cAMP and diacylglycerol) that activate protein kinase A (PKA) and protein kinase C (PKC) in target cells, it is conceivable that either one or both of these pathways can participate in modulating exchanger activity. To discriminate among these possibilities, a series of synthetic PTH and PTHRP fragments were used that stimulate adenylate cyclase and/or PKC. In the osteoblastic cell line UMR-106, human PTH(1-34) and PTHRP(1-34) augmented adenylate cyclase activity, whereas PTH(3-34), PTH(28-42), and PTH(28-48) had no effect. Nevertheless, all these peptide fragments were found to enhance PKC translocation from the cytosol to the membrane in a dose-dependent (10(-11) to 10(-7) M) manner. PTHRP(1-16), a biologically inert fragment, was incapable of influencing either the PKA or PKC pathway. PTH(1-34) and PTHRP(1-34), but not PTH(3-34), PTH(28-42), PTH(28-48), or PTHRP(1-16), elevated Na+/H+ exchanger activity, implicating cAMP as the transducing signal. In accordance with this observation, forskolin (10 microM), which directly stimulates adenylate cyclase, also activated Na+/H+ exchanger activity. The involvement of PKA was verified when the highly specific PKA inhibitor, H-89, completely abolished the stimulatory effect of PTH(1-34) and forskolin on Na+/H+ exchange. In addition, Northern blot analysis revealed the presence of only the NHE-1 isoform of the Na+/H+ exchanger in UMR-106 cells. In summary, these results indicated that PTH and PTHRP activate the Na+/H+ exchanger NHE-1 isoform in osteoblastic UMR-106 cells exclusively via a cAMP-dependent pathway.
A Multimedia Distance Learning Trial Using ISDN BRI (1993)

Distance Learning using multimedia communications can be conducted in a point-to-point or multipoint mode. Trials were conducted at California State University in Chico to assess the viability of using Integrated Services Digital Network (ISDN) Basic Rate Interface (BRI) for transmission of voice, data and video. A prototype multimedia bridge was developed for the multipoint trial based on Definity® telecommunications system technology.
A QoS Monitoring Framework for Composite Web services in the Cloud (2012)

Abstract — Due to the dynamic nature of the Cloud, continuous monitoring of QoS requirements is necessary to manage the Cloud computing environment and enforce service level agreements. In this paper, we propose a QoS monitoring framework for composite Web services implemented using the BPEL process and deployed in the Cloud environment. The proposed framework is composed of three basic modules to: collect low and high level information, analyze the collected information, and take corrective actions when SLA violations are detected. This framework provides for a monitoring approach that modifies neither the server nor the client implementation. In addition, its monitoring approach is based on composition patterns to compute elementary QoS metrics for the composed Web service. In this paper, we illustrate our framework for the response time QoS requirement. Keywords- Monitoring of Web service composition; Cloud environment; Service Level Agreement; SLA violation
Spectroscopic Properties of a Biologically Relevant [Fe2(μ‐O)2] Diamond Core Motif with a Short Iron‐Iron Distance (2022)

Diiron cofactors in enzymes perform diverse challenging transformations. The structures of high valent intermediates (Q in methane monooxygenase and X in ribonucleotide reductase) are debated since Fe-Fe distances of 2.5-3.4 Å were attributed to "open" or "closed" cores with bridging or terminal oxido groups. We report the crystallographic and spectroscopic characterization of a Fe<sup>III</sup> <sub>2</sub> (μ-O)<sub>2</sub> complex (2) with tetrahedral (4C) centres and short Fe-Fe distance (2.52 Å), persisting in organic solutions. 2 shows a large Fe K-pre-edge intensity, which is caused by the pronounced asymmetry at the T<sub>D</sub> Fe<sup>III</sup> centres due to the short Fe-μ-O bonds. A ≈2.5 Å Fe-Fe distance is unlikely for six-coordinate sites in Q or X, but for a Fe<sub>2</sub> (μ-O)<sub>2</sub> core containing four-coordinate (or by possible extension five-coordinate) iron centres there may be enough flexibility to accommodate a particularly short Fe-Fe separation with intense pre-edge transition. This finding may broaden the scope of models considered for the structure of high-valent diiron intermediates formed upon O<sub>2</sub> activation in biology.
Chemical Origins of Electrochemical Overpotential in Surface‐Conversion Nanocomposite Cathodes (2019)

Abstract A new branch of promising nanocomposite cathode materials for rechargeable batteries based on non‐intercalation materials has been recently discovered. However, all the nanocomposite cathodes reported thus far suffer from a large overpotential in the first charge, which hinders the activation and lowers the energy efficiency. Here, a series of model nanocomposites consisting of MnO and various metal fluorides (LiF, NaF, KF, RbF, CsF, MgF 2 , CaF 2 , and AlF 3 ) to identify the key parameters affecting the activation and overpotential in the first charge are evaluated. It is demonstrated that the F 1s binding energy of the metal fluorides is a plausible indicator of the overpotential in the first charge as well as the subsequent reversible discharge capacity. The stability of the cation in the electrolyte and its solvation nature are also shown to affect the overall activation process. Finally, it is proposed that appropriate tuning of the binding energy of metal fluorides (e.g., by forming solid solutions such as LiCsF 2 ) is a feasible approach to reduce the overpotential and increase the reversible capacity. The findings broaden the current understanding of surface‐conversion nanocomposite chemistries, thus providing guidelines for the design of nanomixture cathode materials for rechargeable batteries.
On the assessment of probabilistic WCET estimates reliability for arbitrary programs (2017)

Measurement-Based Probabilistic Timing Analysis (MBPTA) has been shown to be an industrially viable method to estimate the Worst-Case Execution Time (WCET) of real-time programs running on processors including several high-performance features. MBPTA requires hardware/software support so that program's execution time, and so its WCET, has a probabilistic behaviour and can be modelled with probabilistic and statistic methods. MBPTA also requires that those events with high impact on execution time are properly captured in the (R) runs made at analysis time. Thus, a representativeness argument is needed to provide evidence that those events have been captured. This paper addresses the MBPTA representativeness problems caused by set-associative caches and presents a novel representativeness validation method (ReVS) for cache placement. Building on cache simulation, ReVS explores the probability and impact (miss count) of those cache placements that can occur during operation. ReVS determines the number of runs R , which can be higher than R, such that those cache placements with the highest impact are effectively observed in the analysis runs, and hence, MBPTA can be reliably applied to estimate the WCET.
Up-Regulated Expression of the cbb I and cbb II Operons during Photoheterotrophic Growth of a Ribulose 1,5-Bisphosphate Carboxylase-Oxygenase Deletion Mutant of Rhodobacter sphaeroides (2002)

In a Rhodobacter sphaeroides ribulose 1,5-bisphosphate carboxylase-oxygenase deletion strain that requires an exogenous electron donor for photoheterotrophic growth, transcription of the genes of the Calvin-Benson-Bassham (CBB) cycle was increased. This finding pointed to a potential physiological effector that enhances the capability of the positive transcriptional activator CbbR to mediate cbb transcription. This effector is most likely ribulose 1,5-bisphosphate or a metabolite derived from this CBB pathway intermediate.