gebhart/patrepeval huggingface dataset:
Comparison of the Adsorption of Different Charge Density Polyelectrolytes:  A Quartz Crystal Microbalance and X-ray Photoelectron Spectroscopy Study (2003)

The adsorption of a series of six cationic polyelectrolytes onto a gold surface was monitored via a quartz crystal microbalance with dissipation (QCM-D). The series of polyelectrolytes were chemically similar but differing in the ratio of two randomly ordered constituent monomers, one of which was charged, the other neutral. Thus the series of polyelectrolytes differed systematically in their charge densities, ranging from a high charge density (100% of monomers charged) to a low charge density (1% charged). It was determined that high charge density polyelectrolytes adsorbed in a relatively flat and rigid layer, while the low charge density polyelectrolyte, as expected, adsorbed in a much more extended structure that coupled strongly to the bulk solvent. By comparison to X-ray photoelectron spectroscopy results, we have also calculated the relative solvent mass hydrodynamically coupled to the adsorbed polymer, which ranges from almost 80% solvent for the 1% charged case down to close to zero for the 100% charged case. Since the QCM-D results are measured relative to uncoated gold in aqueous solution, the latter results should be interpreted as showing that the amount of water hydrodynamically coupled to gold and that coupled to gold coated with the 100% charged polyelectrolyte is very similar. It is believed that this systematic study on the effect of polyelectrolyte structure on the measured dissipation change in the QCM-D may serve as a first guide when inferring structural and viscoelastic information based solely on the QCM-D technique for other similar systems. In addition, a preliminary study on the ability of one polymer to replace another preadsorbed polymer layer was conducted that showed that a steric layer was able to prevent the adsorption of a thermodynamically more favorable polymer. In the reverse case, greater exchange was possible.
Tobacco nicotine uptake permease (NUP1) affects alkaloid metabolism (2011)

An effective plant alkaloid chemical defense requires a variety of transport processes, but few alkaloid transporters have been characterized at the molecular level. Previously, a gene fragment encoding a putative plasma membrane proton symporter was isolated, because it was coordinately regulated with several nicotine biosynthetic genes. Here, we show that this gene fragment corresponds to a Nicotiana tabacum gene encoding a nicotine uptake permease (NUP1). NUP1 belongs to a plant-specific class of purine uptake permease-like transporters that originated after the bryophytes but before or within the lycophytes. NUP1 expressed in yeast cells preferentially transported nicotine relative to other pyridine alkaloids, tropane alkaloids, kinetin, and adenine. NUP1-GFP primarily localized to the plasma membrane of tobacco Bright Yellow-2 protoplasts. WT NUP1 transcripts accumulated to high levels in the roots, particularly in root tips. NUP1-RNAi hairy roots had reduced NUP1 mRNA accumulation levels, reduced total nicotine levels, and increased nicotine accumulation in the hairy root culture media. Regenerated NUP1-RNAi plants showed reduced foliar and root nicotine levels as well as increased seedling root elongation rates. Thus, NUP1 affected nicotine metabolism, localization, and root growth.
Evaluation for riding comfort of railway vehicle with optical topography (2016)

We evaluated the ride comfort of high-speed railway vehicle for the section between Morioka and Shin-Aomori in Tohoku Shinkansen-line by using the optical topography. Although the result shows the unclear correlation between the ride quality level and the stress brain index (LIR) estimated by the difference between left and right cerebral blood flow, we obtained the clear correlation between the tendency of ride quality level variation and LIR variation for the each section. For the correlation parameters between differences of LIR and ride quality level, 0.72 for the vertical vibration and 0.69 for the lateral vibration, respectively, were obtained. In addition, we found that the objective estimation of the optical topography has a high potential to evaluate the riding comfort for the total experimental condition in detail under the time series and/or the running section.
Mach Conference, 2022. (2022)

There has been considerable interest in chemical vapor infiltration (CVI) manufactured silicon carbide fiber and silicon carbide matrix (SiC/SiC) composite tubes due to their superior mechanical properties. The SiC/SiC tubes are known to remain stable even after prolonged exposure to radiation. However, there are many variables in the manufacturing of SiC/SiC composite tubes such as elastic constants of constituent SiC fiber and SiC matrix, braiding angle, porosity, and others whose values vary over a range. The intention is to identify the distribution of elastic constants of SiC/SiC tubes which would help model the performance of the novel cladding material. To do so, a sensitivity analysis will be carried out to determine the dominant variables that influence the elastic constants of SiC/SiC tubes. A chosen number of combinations of dominant variables will be sampled through the Latin hypercube sampling (LHS) method. The elastic constants of composite tube namely Young's moduli in the circumferential and longitudinal direction, Poisson's ratio, and shear modulus will be calculated at sampled points through finite element (FE) analysis. A polynomial response surface (PRS) will be built for each of the elastic constants to be used as a surrogate to FE analysis. Once the predictive accuracy of PRS is verified at the validation set of data points, the PRS will be invoked 105 times in Monte Carlo simulations (MCS). The uncertainty can be quantified by calculating the coefficient of variation (CV) based on MCS-generated data which will be presented at the conference.
Research on application of block chain in distributed energy transaction (2017)

With the promotion of electric power reform in China, distributed energy participating in power market transaction becomes possible. However, due to the characteristics of transaction decentralization, multiple energy synergies, information symmetry and the large quantity, the transaction cost and the risk of information leak increase significantly, which inhibits the enthusiasm of distributed energy to participate in electric power transaction. The block chain has been widely used in finance, logistics and other industries because of its decentralized data processing. In this paper, the characteristics and infrastructure of the block chain is analyzed and the distributed energy trading frame work based on the block chain is built. The result shows that block chain has significant effect on the information security of the energy transaction.
YEAST ALCOHOL DEHYDROGENASE, A ZINC METALLOENZYME (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTYEAST ALCOHOL DEHYDROGENASE, A ZINC METALLOENZYMEBert L. Vallee and Frederic L. HochCite this: J. Am. Chem. Soc. 1955, 77, 3, 821–822Publication Date (Print):February 1, 1955Publication History Published online1 May 2002Published inissue 1 February 1955https://pubs.acs.org/doi/10.1021/ja01608a103https://doi.org/10.1021/ja01608a103research-articleACS PublicationsRequest reuse permissionsArticle Views591Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Preparation and application of water-soluble polymer-metal complexes (1980)

A series of water-soluble polymers and derivatives with chelating groups has been prepared and investigated for the complex formation with various metals. The complexation of basis polymers, such as poly(ethyleneiruine) , poly(vinylamine) , and poly(acrylic acid), as well as copolymers was carried out in homogeneous phase. Membrane filtration allowed continuous or discontinuous separation of the polymer chelates from metallic ions not bound to the polymer. The polymer complexes remained water-soluble independent of the chelated metal and the polymeric ligand. Studies on the dependency of the capacities of the polymers upon various parairters and methods for regenerating the polymeric ligands are described. The introduction of chelating groups, e.g. pyridine-2-aldimine, thiourea, iminodiacetic acid, 8-hydroxy quinoline, and hydroxyaniline, to the macromolecules by polymer-analogous reaction or by copolymerization improved significantly the selectivity for the metals cobalt, nickel, copper, cadmium, palladium, mercury, silver, gold, and platinum. By the use of membrane filtration in the preparation and application of water-soluble polymer-metal complexes it is possible to recover metal ions from solutions in a short time and in homogeneous phase.
Supplementary Methods from Exploiting the Mutanome for Tumor Vaccination (2023)

&lt;p&gt;PDF file - 101K&lt;/p&gt;
Le Code du Mariage et de la Famille de la République de Russie (1970)

info:eu-repo/semantics/published
Sustained Down-regulation of the Epidermal Growth Factor Receptor by Decorin (2000)

The small leucine-rich proteoglycan decorin interacts with the epidermal growth factor receptor (EGFR) and triggers a signaling cascade that leads to elevation of endogenous p21 and growth suppression. We demonstrate that decorin causes a sustained down-regulation of the EGFR. Upon stable expression of decorin, the EGFR number is reduced by approximately 40%, without changes in EGFR expression. However, EGFR phosphorylation is nearly completely abolished. Concurrently, decorin attenuates the EGFR-mediated mobilization of intracellular calcium and blocks the growth of tumor xenografts by down-regulating the EGFR kinase in vivo. Thus, decorin acts as an autocrine and paracrine regulator of tumor growth and could be utilized as an effective anti-cancer agent.
Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate (2001)

Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK). By phosphorylating inositol 4,5-bisphosphate, mIPMK provides an alternative biosynthesis for inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)]. mIPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-InsP(4)) from InsP(5). Additionally, mIPMK forms InsP(4) from Ins(1,4,5)P(3) and InsP(5) from Ins(1,3,4,5)P(4).
Encoding in Style: a StyleGAN Encoder for Image-to-Image Translation (2021)

We present a generic image-to-image translation framework, pixel2style2pixel (pSp). Our pSp framework is based on a novel encoder network that directly generates a series of style vectors which are fed into a pretrained StyleGAN generator, forming the extended $\mathcal{W} + $ latent space. We first show that our encoder can directly embed real images into $\mathcal{W} + $, with no additional optimization. Next, we propose utilizing our encoder to directly solve image-to-image translation tasks, defining them as encoding problems from some input domain into the latent domain. By deviating from the standard "invert first, edit later" methodology used with previous StyleGAN encoders, our approach can handle a variety of tasks even when the input image is not represented in the StyleGAN domain. We show that solving translation tasks through StyleGAN significantly simplifies the training process, as no adversary is required, has better support for solving tasks without pixel-to-pixel correspondence, and inherently supports multi-modal synthesis via the resampling of styles. Finally, we demonstrate the potential of our framework on a variety of facial image-to-image translation tasks, even when compared to state-of-the-art solutions designed specifically for a single task, and further show that it can be extended beyond the human facial domain. Code is available at https://github.com/eladrich/pixel2style2pixel.
Bio-dielectrics based on DNA-Ceramic hybrid films for potential energy storage applications (2011)

The potential of DNA-based dielectrics for energy storage applications was explored via the incorporation of high dielectric constant (&epsilon;) ceramics such as TiO2 (rutile) and BaTiO3 in the DNA bio-polymer. The DNA-Ceramic hybrid films were fabricated from stable suspensions of the nanoparticles in aqueous DNA solutions. Dielectric characterization revealed that the incorporation of TiO2 (rutile) in DNA resulted in enhanced dielectric constant (14.3 at 1 kHz for 40 wt % TiO2) relative to that of DNA in the entire frequency range of 1 kHz-1 MHz. Variable temperature dielectric measurements, in the 20-80&deg;C range, of both DNA-TiO2 and DNA-BaTiO3 films, revealed that the ceramic additive stabilizes DNA against large temperature-dependent variations in both &epsilon; and the dielectric loss factor tan &delta;. The bulk resistivity of the DNA-Ceramic hybrid films, in the case of both TiO2 and BaTiO3 additives in DNA, was measured to be two to three orders of magnitude higher than that of the control DNA films, indicating their potential for utilization as insulating dielectrics in capacitor applications. As a part of a baseline study, results based on a comparison of the temperature-dependent dielectric behavior of DNA and DNA-CTMA complex films as well as their frequency-dependent polarization behavior, are also discussed.
Single Institution Review of Patients With Prior Breast Augmentation Undergoing Breast Conservation Therapy for Breast Cancer (2017)

Our results indicate that, from the oncological standpoint, patients with prior augmentation can undergo lumpectomy with equivalent tumor margins and re-excision rates. To the best of our knowledge, this is the first reported comparative study between these 2 groups.
A17402 Mid-regional proadrenomedullin predicts reduced blood pressure and glucose elevation over time despite enhanced progression of obesity markers (2018)

Objectives: Elevated plasma levels of the vasodilating hormone adrenomedullin (ADM) predict cardiovascular disease and have been associated with hypertension and obesity. We aimed to examine the independent relationship between ADM and the progression of cardiometabolic risk factors during long-term follow-up. Methods: We studied mid-regional pro-adrenomedullin (MR-proADM) in fasting plasma in 3298 subjects from the population-based Malmö Diet and Cancer Study-Cardiovascular cohort, re-examined after 17 years, and related baseline MR-proADM to cardiometabolic risk factors cross sectionally and longitudinally. Results: At baseline, after full adjustment, each standard deviation (SD) increment of MR-proADM was independently related to (beta ± standard error, P-value) higher systolic blood pressure (SBP) (0.956 ± 0.319 mmHg, P = 0.003), body mass index (BMI) (0.912 ± 0.061 kg/m2, P = 1.42 x 10–48), waist (2.28 ± 0.158 cm, P = 8.46 x 10–46) and fasting blood glucose (FBG) (0.046 ± 0.018 mmol/L, P = 0.01). After full adjustment, including the baseline level of the risk factor whose degree of progression was studied, each SD increment of MR-proADM predicted significantly reduced progression of SBP ( − 1.170 ± 0.337 mmHg, P = 0.001) and FBG ( − 0.055 ± 0.023 mmol/L, P = 0.015), but greater increase of BMI (0.101 ± 0.051 kg/m2, P = 0.047) and waist (0.600 ± 0.144 cm, P = 3.1 x 10–5). Conclusion: Despite cross-sectional associations with higher levels of blood pressure and glucose, high levels of MR-proADM predict a slower progression of blood pressure and glycemia during long-term follow-up. Conversely, the cross sectional associations with higher levels of MR-proADM and obesity were paralleled by a faster progression of obesity markers over time. These results may be important for assessment of long term effects of therapies modulating levels of ADM.
Down-regulation of natural killer cell activity in MoLV leukemogenesis: evidence for tumor-cell-mediated suppression. (1988)

The role of natural killer (NK) cells in retrovirus-induced leukemogenesis was studied. These cells which do not require prior sensitization are considered as a part of the body's defense system against tumor development and spread. Neonate BALB/c mice infected with Moloney murine leukemia virus (MoLV) develop leukemia within 3-6 months. The MoLV-infected mice showed a progressive loss of endogenous and augmented NK activity, correlated with the development of the leukemic state. Mixing of spleen cells from tumor-bearing mice with NK-augmented splenocytes resulted in suppression of NK activity. In addition, mixing of T cell lines isolated from MoLV-induced tumors with augmented splenocytes also resulted in the down-regulation of NK cell activity. The present study demonstrates that tumor cells from leukemic organs and leukemic T cell lines can actively suppress NK cell function. It is postulated that after MoLV infection the progression of virus-transformed T cells to a fully developed tumor depends on the ability of these cells to down-regulate NK cell activity and thus escape immune surveillance.
The USTC-NELSLIP Systems for Simultaneous Speech Translation Task at IWSLT 2021 (2021)

This paper describes USTC-NELSLIP's submissions to the IWSLT2021 Simultaneous Speech Translation task. We proposed a novel simultaneous translation model, Cross Attention Augmented Transducer (CAAT), which extends conventional RNN-T to sequence-to-sequence tasks without monotonic constraints, e.g., simultaneous translation. Experiments on speech-to-text (S2T) and text-to-text (T2T) simultaneous translation tasks shows CAAT achieves better quality-latency trade-offs compared to \textit{wait-k}, one of the previous state-of-the-art approaches. Based on CAAT architecture and data augmentation, we build S2T and T2T simultaneous translation systems in this evaluation campaign. Compared to last year's optimal systems, our S2T simultaneous translation system improves by an average of 11.3 BLEU for all latency regimes, and our T2T simultaneous translation system improves by an average of 4.6 BLEU.
On studying asymmetric membranes made from polymethylmethacrylate/xylene by the thermal-inversion method. (1989)

Both polydisperse and monodisperse PMMA/xylene phase diagrams have been determined successfully by applying the optical density method. The changes in optical density for the polydisperse PMMA system are not as dramatic as the changes for the monodisperse PMMA system. Through the thermal-inversion process, the asymmetric membranes can be successfully made for this PMMA/xylene system. In the later stages of phase separation by spinodal decomposition, the flow properties of the PMMA/xylene system play a vital role in determining the final membrane microstructure. During the very early stage of phase separation by spinodal decomposition, a membrane with lacy structure results. In contrast, during the later stage of phase separation, a membrane structure with small pores dispersed in the polymer matrix results.
Influence of Ga-concentration on the electrical and magnetic properties of magnetoelectric CoGaxFe2−xO4/BaTiO3 composite (2015)

Multiferroic materials exhibit magnetoelectric (ME) coupling and promise new device applications including magnetic sensors, generators, and filters. An effective method for developing ME materials with enhanced ME effect is achieved by the coupling through the interfacial strain between piezoelectric and magnetostrictive materials. In this study, the electrical and magnetic properties of Ga doped magnetoelectric CoGaxFe2−xO4/BaTiO3 composite are studied systematically. It is found that Ga doping improves the sensitivity of magnetoelastic response and stabilizes the magnetic phase of the composites. More importantly, Ga doping reduces the electrical conductivity of composite, as well as the dielectric loss. An enhancement of the electrostrain with doping Ga is also observed. Quantitative estimation indicates that magnetoelectric coupling is enhanced for Ga-doped CoGaxFe2−xO4/BaTiO3 composites. Thus, the present work is beneficial to the practical application of composite CoFe2O4/BaTiO3-based multiferroic materials.
The Early Natural History of Nephropathy in Type 1 Diabetes (2002)

Renal structural abnormalities are known to precede the development of proteinuria, hypertension, and reduced renal function in patients with type 1 diabetes. The determinants of these early structural abnormalities are, however, largely unknown. The International Diabetic Nephropathy Study (IDNS) has recruited 243 children and adults (aged 10-40 years) in Montreal, Minneapolis, and Paris to identify and quantify these determinants. All study subjects were normotensive and had normal-to-high glomerular filtration rates (GFRs) and urinary albumin excretion rates (AERs) <100 microg/min at study entry. Only 8 of 243 had an AER > or =20 microg/min (microalbuminuria). Two renal biopsies are obtained at a 5-year intervals, with baseline and follow-up measures of renal function, blood pressure (BP), HbA(1c), plasma lipids, and AER. Herein, we examine the baseline renal biopsy morphometric findings in these subjects and in 87 kidney donor control subjects and explore the associations between findings and clinical and demographic variables. The principal morphometric abnormalities were increased glomerular basement membrane (GBM) width and fractional volume of mesangium [Vv(Mes/glom)] and mesangial matrix [Vv(MM/glom)]. The frequency of these abnormalities increased with increasing duration of diabetes but was observed as early as 2-8 years after onset. Diastolic BP (DBP), but not HbA(1c), was directly associated with these abnormalities. Elevated GFR was associated with only a small increase in peripheral glomerular capillary basement membrane filtration surface density. Center differences were detected in renal structural, renal functional, and BP parameters, especially between the Paris and North American centers. GBM width, Vv(Mes/glom), and Vv(MM/glom) are significantly increased even within a few years of onset of type 1 diabetes. These changes are detectable in normoalbuminuric patients and are related to duration, BP, and study site. Changes in these and other morphometric measures over 5-year follow-up should help clarify the roles of glycemia and other determinants of the rates of development of diabetic nephropathy lesions, as well as their relationships to early changes in BP, albumin excretion, and renal function.
Gene Therapy for Adenosine Deaminase Deficiency and Malignant Solid Tumors (1994)

Gene therapy may be considered the ultimate treatment for genetic diseases (Anderson, 1984). The possibility of reversing genetic defects by replacing the defective gene instead of merely treating symptoms is very appealing. Significant progress in the development of clinical applications of gene therapy has occurred. More than 40 human gene transfer and therapy experiments have been initiated since the introduction of this approach in 1989 (Anderson, 1992; Miller, 1992).