gebhart/patrepeval huggingface dataset:
Sporadic frame dropping impact on quality perception (2004)

Over the past few years there has been an increasing interest in real time video services over packet networks. When considering quality, it is essential to quantify user perception of the received sequence. Severe motion discontinuities are one of the most common degradations in video streaming. The end-user perceives a jerky motion when the discontinuities are uniformly distributed over time and an instantaneous fluidity break is perceived when the motion loss is isolated or irregularly distributed. Bit rate adaptation techniques, transmission errors in the packet networks or restitution strategy could be the origin of this perceived jerkiness. In this paper we present a psychovisual experiment performed to quantify the effect of sporadically dropped pictures on the overall perceived quality. First, the perceptual detection thresholds of generated temporal discontinuities were measured. Then, the quality function was estimated in relation to a single frame dropping for different durations. Finally, a set of tests was performed to quantify the effect of several impairments distributed over time. We have found that the detection thresholds are content, duration and motion dependent. The assessment results show how quality is impaired by a single burst of dropped frames in a 10 sec sequence. The effect of several bursts of discarded frames, irregularly distributed over the time is also discussed.
Netscape IFC in a nutshell : a desktop quick reference for Java programmers (1997)

Inspired by the bestselling in a Nutshell, IFC in a Nutshell is a quick reference and programmer's guide to the Internet Foundation Classes (Version 1.1) from Netscape. This book contains all the documentation programmers need to start creating highly customizable, great looking graphical user interfaces (GUIs) for their applets and applications. In addition to the complete and thorough quick reference, IFC in a Nutshell also contains more than 20 tutorial-style, example-based chapters that introduce each of the features and GUI components of the IFC. These features include: A Pure Java platform-independent, customizable look-and-feel, with a complete suite of GUI componentsIntra-application drag-and-dropMulti-font formatted text display, with a built-in HTML parserPre-defined color, font, and file-selection dialog boxesTimer objects that simplify animation by replacing threadsConstructor, an interface builder application freely available from Netscape The IFC 1.1 library is freely available on the Internet, for use in any application or with any Java-capable Web browser, and is bundled with Netscape's Navigator 4.0 Web browser, making it the ideal, and preferred, development library for that platform.The Netscape IFC classes documented in this book will strongly influence the development of the Foundation Classes (JFC), under development by Sun, Netscape, IBM, and others. The JFC will reportedly merge IFC technology with Sun's AWT GUI toolkit. Although the JFC will eventually supersede the IFC, the IFC is a powerful class library, is availablenow, and is a very useful and stable predecessor to the JFC. Developers, particularly those targeting the Navigator 4.0 platform, should begin right away to take advantage of the advanced GUI features of the IFC, secure in the knowledge that Netscape will provide a migration path to the JFC, when it eventually becomes available. Experience now with the IFC will give programmers a head-start on the JFC.
Sintering by infiltration of loose mixture of powders, a method for metal matrix composite elaboration (1993)

Starting from the observation that Sintering by Infiltration of Loose Mixture of Powders confers large possibilities for both complex shaped and of large dimensions Particulate Reinforced Metal Matrix Composite components elaboration, its mechanism comparative with those of the classical melt infiltration was investigated. Appropriate measures in order to prevent an excessive hydrostatic flow of the melt and, consequently, reinforcement particle dispersion, as well as to promote wetting in both infiltration and liquid phase sintering stages of the process were established as necessary. Some experimental results in the method application to the fusion tungsten carbide and diamond reinforced metal matrix composite elaboration are, also, presented.
Network management standards: approaches by T1M1 and an LEC perspective (1990)

The authors present an overview of TSC T1M1 standards projects, as well as important standards required for remote management and operation of a telecommunications network. They provide an LEC (local exchange carrier) perspective on the need for a standard interface to facilitate end-to-end customer network management and they describe a new, related standards project in T1M1.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The influence of exercise during growth on ultrasonographic parameters of the superficial digital flexor tendon of young Thoroughbred horses (2008)

A moderate amount of early conditioning exercise against a background of constant exercise at pasture is not harmful to the development of the flexor tendons.
Morphological and Phenotypic Analyses of the Human Placenta Using Whole Mount Immunofluorescence1 (2014)

The human placenta performs multiple essential functions required for successful pregnancy. Alterations in the placental vasculature have been implicated in severe complications of pregnancy. Despite the importance of placental vascular function during pregnancy, there are gaps in our knowledge regarding the molecular pathways that control vessel development. Furthermore, there are limited tools available to simultaneously examine the morphology, phenotype, and spatial arrangement of cells within intact placental structures. To overcome these limitations, we developed whole mount immunofluorescence (WMIF) of the human placenta. Morphological analyses using WMIF revealed that blood vessel structures were consistent with an immature, angiogenic morphology in first-trimester placentas and mature, remodeled endothelium at term. To investigate placental expression of factors that control blood vessel development, we utilized WMIF to examine gestation age-specific expression of 1) the receptors for vascular endothelial growth factor (VEGFR-1, VEGFR-2, and VEGFR-3), which are required for placental vascular development in mice, and 2) activated, tyrosine phosphorylated STAT3 (pSTAT3), a transcription factor that mediates VEGFR2 signaling. We detected high levels of VEGFR2, VEGFR3, and pSTAT3 expression in early placental blood vessels that were significantly diminished by term. VEGFR1 was expressed primarily in trophoblast and Hofbauer cells throughout gestation. Based on our collective results, we propose that VEGFR2, VEGFR3, and STAT3 play essential roles in the development of the human placental vasculature. In addition, we anticipate that WMIF will provide a powerful approach for comparing placental morphology and protein expression in normal versus pathological pregnancies and for investigating the effects of environmental factors on placental function.
Slow frequency hopping solutions for GSM networks of small bandwidth (2002)

Slow frequency hopping is a quality and capacity enhancement feature for the GSM system. However, in order to achieve a significant gain from frequency hopping, it has been shown that at least 3 to 4 frequencies are required in the hopping sequence. In band-limited networks that many frequencies per cell are not always available. Two network features, MAIO-management (mobile allocation index offset management) and using a lower reuse with admission load control, compensate for the lack of spectrum even with very narrow bandwidths. The performance of these two features have been investigated and compared to a non-hopping network. A network with a bandwidth of 21 frequencies has been analysed. Simulation results show that MAIO-management gives the best quality. The comparison is based on individually reported frame erasure rates of each mobile station.
Inclusion complexes of .BETA.-cyclodextrin with antiinflammatory drugs fenamates in aqueous solution. (1975)

Inclusion of antiinflammatory drugs fenamates within the cavity of β-cyclodextrin in aqueous solution was confirmed by circular dichroism, ultraviolet absorption, and nuclear magnetic resonance spectroscopies. Solubility and spectral changes were quantitatively investigated and stoichiometric ratio, which was found to be 1 : 1, formation constants, and thermodvnamic parameters were obtained for complex formation of β-cyclodextrin with fenamates. Hydrophobic and steric factors were reflected in the values of formation constants. Isoequilibrium relationship between ΔH and ΔS values were observed having a compensation temperature of 284°K. From these evidences mode of inclusion was discussed.
Spatialized audio for mixed reality theater: the Egyptian oracle (2012)

In the Egyptian Oracle, we project a simulation of an ancient temple onto a large projection screen. (See
Recovery and Composition of Swiss Cheese Whey Lipid-Containing Fractions (1997)

Cheese whey contains 0.1−0.2% residual lipids. The present study was conducted to develop a high-speed centrifugation procedure for fractionating and recovering residual whey lipids (RWL) from commercial Swiss cheese whey (SCW) and to determine the yields and compositions of the resulting fractions. Three RWL fractions were obtained: (1) a low-density lipid-containing fraction (LDLF) at the top of the centrifuge tubes; (2) a medium-density lipid-containing fraction (MDLF) in the clear, middle zone; and (3) a high-density lipid-containing fraction (HDLF) in the small, compact, and gelatinous pellet at the bottom of the centrifuge tubes. LDLF, MDLF, and HDLF contained about 95, 5, and 0.13% of the total SCW lipids, respectively. Palmitic acid was the major fatty acid, and oleic, stearic and myristic acids were present in lower concentrations. The major phospholipid components of all three SCW lipid fractions were phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin. Keywords: Swiss cheese whey; residual whey lipids; centrifugation; fractionation
Hyperaldosteronism caused by sertraline (2022)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism (2020)

Recurrent venous thromboembolism (VTE) occurs infrequently following a provoked event but occurs in up to 30% of individuals following an initial unprovoked event. There is limited understanding of the biological mechanisms that predispose patients to recurrent VTE.
Altered calcium handling is an early sign of streptozotocin-induced diabetic cardiomyopathy (2006)

The main objective of the present study was to determine alterations of calcium handling in the diabetic rat heart during the transition from adaptive to maladaptive phase of cardiomyopathy. By inhibiting the nuclear enzyme poly(ADP-ribose) polymerase (PARP), we also investigated the possible role of this enzyme in the sequence of pathological events. Six weeks after induction of type I diabetes by injection of streptozotocin in rats, the hearts were perfused according to Langendorff. Intracellular-free calcium (Ca(2+)(i)) levels were measured by surface fluorometry using Indo-1 AM. Cyclic changes in Ca(2+)(i) concentrations and hemodynamic parameters were measured simultaneously. The hearts were challenged by infusion of isoproterenol. Six weeks of diabetes resulted in reduced inotropy and lusitropy. The diabetic hearts (DM) expressed a significantly elevated end-diastolic Ca(2+)(i) level (control, 111-/+20 vs DM, 221-/+35 nM). The maximal transport capacity of SERCA2a and conductance of RyR2 were reduced. These changes were not accompanied by major alterations in the tissue content of SERCA2a, RyR2, phospholamban and Na(+)/Ca(2+) exchanger. In response to beta-adrenergic activation, SERCA2a transport capacity and RyR2 conductance were stunted in the DM hearts. Inhibition of PARP induced minor changes in the mechanical function and calcium handling of the DM hearts. In conclusion, the observed changes in contractility and in Ca(2+)(i) handling are most likely attributable to functional disturbances of SERCA2a and RyR2 in this transitional phase of diabetes. At this stage of diabetes, PARP does not appear to play a significant pathogenetic role in the alterations in contractile function and calcium handling.
Distribution of Tocotrienols in Rats Fed a Rice Bran Tocotrienol Concentrate (2007)

To examine the distribution of rice bran tocotrienol (T3), we gave rice bran T3 to rats after considering an acceptable daily intake of vitamin E for humans. Male SD rats (5 weeks of age) were fed for 3 weeks on a commercial diet containing 6.4 mg of vitamin E per 100 g wt and additively received vitamin E or the vehicle (vitamin E-free corn oil) by oral intubation. The animals were randomly divided into 4 groups depending on the type of test diet: control (vehicle), non-T3 (no T3 + 4.3 mg of tocopherol (TOC)/kg body weight (b.w.)/day), low-T3 (0.8 mg T3 + 3.5 mg TOC/kg b.w./day), and high-T3 (3.2 mg T3 + 1.1 mg TOC/kg b.w./day). The control rats and rats in the non-T3, low-T3, and high-T3 groups took 4.3 and 8.6 mg of vitamin E/kg b.w./day, respectively. Rice bran gamma-T3 was significantly distributed to the adipose tissue and increased from 1.1 to 10.2 nmol/g of adipose tissue according to the rice bran T3 intake.
Automated high-throughput high-content autophagy and mitophagy analysis platform (2019)

Autophagic processes play a central role in cellular homeostasis. In pathological conditions, the flow of autophagy can be affected at multiple and distinct steps of the pathway. Current analyses tools do not deliver the required detail for dissecting pathway intermediates. The development of new tools to analyze autophagic processes qualitatively and quantitatively in a more straightforward manner is required. Defining all autophagy pathway intermediates in a high-throughput manner is technologically challenging and has not been addressed yet. Here, we overcome those requirements and limitations by the developed of stable autophagy and mitophagy reporter-iPSC and the establishment of a novel high-throughput phenotyping platform utilizing automated high-content image analysis to assess autophagy and mitophagy pathway intermediates.
Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes (2020)

Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term health. The underlying mechanisms and effective interventions to abrogate such effect remain unclear. Our previous studies demonstrated impaired mitochondrial biogenesis in male human placenta of diabetic mothers. In the present studies, epigenetic marks possibly related to mitochondrial biogenesis in placentae of women with diabetes (n = 23) and controls (n = 23) were analyzed. Effects of metformin were examined in human placental explants from a subgroup of diabetic women and in a mouse model of maternal high fat diet feeding. We found that maternal diabetes was associated with epigenetic regulation of mitochondrial biogenesis in human placenta in a fetal sex-dependent manner, including decreased histone acetylation (H3K27 acetylation) and increased promoter methylation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). In male placenta, the levels of H3K27 acetylation and PGC-1α promoter methylation correlated significantly with the activity of AMP-activated protein kinase (AMPK). Metformin treatment on male diabetic placental explant activated AMPK and stimulated PGC-1α expression, concomitant with increased H3K27 acetylation and decreased PGC-1α promoter methylation. In vivo, we show that maternal metformin treatment along with maternal high fat diet significantly increased mouse placental abundance of PGC-1α expression and downstream mitochondrial transcription factor A (TFAM) and inhibited maternal high fat diet-impaired placental efficiency and glucose tolerance in offspring. Together, these findings suggest the capability of metformin to stimulate placental mitochondrial biogenesis and inhibit the aberrant epigenetic alterations occurring in maternal diabetes during pregnancy, conferring protective effects on offspring.
Recycled Tyre Rubber Modified Bitumens for road asphalt mixtures: A literature review (2013)

Nowadays, only a small percentage of waste tyres are being land-filled. The Recycled Tyre Rubber is being used in new tyres, in tyre-derived fuel, in civil engineering applications and products, in moulded rubber products, in agricultural uses, recreational and sports applications and in rubber modified asphalt applications. The benefits of using rubber modified asphalts are being more widely experienced and recognized, and the incorporation of tyres into asphalt is likely to increase. The technology with much different evidence of success demonstrated by roads built in the last 40 years is the rubberised asphalt mixture obtained through the so-called “wet process” which involves the utilisation of the Recycled Tyre Rubber Modified Bitumens (RTR-MBs). Since 1960s, asphalt mixtures produced with RTR-MBs have been used in different parts of the world as solutions for different quality problems and, despite some downsides, in the majority of the cases they have demonstrated to enhance performance of road’s pavement. This study reports the results of a literature review upon the existing technologies and specifications related to the production, handling and storage of RTR-MBs and on their current applications within road asphalt mixtures. Furthermore, considering that RTR-MBs technologies are still struggling to be fully adopted worldwide, mainly because of poor information, lack of training of personnel and stakeholders and rare support of local policies, the present work aims to be an up-to-date reference to clarify benefits and issues associated to this family of technologies and to finally provide suggestions for their wide-spread use.
Targeting Exercise Interventions to Patients With Cancer in Need: An Individual Patient Data Meta-Analysis (2018)

Although exercise should be encouraged for most cancer patients during and post-treatments, targeting specific subgroups may be especially beneficial and cost effective. For fatigue and PF, interventions during and post-treatment should target patients with high fatigue and low PF. During treatment, patients experience benefit for muscle strength and QoL regardless of baseline values; however, only patients with low baseline values benefit post-treatment. For aerobic fitness, patients with low baseline values do not appear to benefit from exercise during treatment.
Optimization of output power and transmission efficiency of magnetically coupled resonance wireless power transfer system (2018)

Magnetically coupled resonance (MCR) wireless power transfer (WPT) system is a promising technology in electric energy transmission. But, if its system parameters are designed unreasonably, output power and transmission efficiency will be low. Therefore, optimized parameters design of MCR WPT has important research value. In the MCR WPT system with designated coil structure, the main parameters affecting output power and transmission efficiency are the distance between the coils, the resonance frequency and the resistance of the load. Based on the established mathematical model and the differential evolution algorithm, the change of output power and transmission efficiency with parameters can be simulated. From the simulation results, it can be seen that output power and transmission efficiency of the two-coil MCR WPT system and four-coil one with designated coil structure are improved. The simulation results confirm the validity of the optimization method for MCR WPT system with designated coil structure.
Mast Cell - Glia Dialogue in Chronic Pain and Neuropathic Pain: Blood-Brain Barrier Implications (2016)

Mast cells and microglia, working singly and in partnership, produce proinflammatory agents which play key roles in a wide array of nervous system disorders. Such neuroinflammatory settings may compromise integrity of both the blood-nerve barrier and blood-brain barrier (BBB) and blood-spinal cord barrier. While both belong to the innate immune system mast cells are far more ubiquitous, are resident in peripheral nerves and the central nervous system, and can influence blood-nerve barrier characteristics. Mast cells, being near the perivasculature especially within the dura, on the brain side of the BBB, are strategically located to play havoc with the BBB. Mast cells and glia are endowed with homeostatic mechanisms/molecules which come into play following tissue damage. These include the N-acylethanolamine family, especially N-palmitoylethanolamine, which is posited to be a key player in maintaining cellular homeostasis against external stressors provoking, for example, inflammation. This review is intended as an overview covering the pathobiology of neuroinflammation in the context of mast cells and microglia, their role in BBB integrity, and therapeutic perspectives in targeting these cells to preserve BBB function.
Switching patients with schizophrenia from paliperidone palmitate to aripiprazole lauroxil: A 6-month, prospective, open-label study (2019)

We assessed the effectiveness of switching from paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) to aripiprazole lauroxil (AL). Prospective, 6-month study in patients with schizophrenia with residual symptoms or intolerance with PP/RLAI. Effectiveness assessed via all-cause and medication-related discontinuation; CGI-S/BPRS and adverse event monitoring assessed efficacy/tolerability, respectively. Fifty-one patients (n = 50 PP; n = 1 RLAI) enrolled; 35 completed the study. All-cause and medication-related discontinuation was 30% and 9% over 6 months, respectively. CGI-S/BPRS improved significantly in those continuing treatment. Adverse events were generally mild to moderate. Patients with efficacy or tolerability concerns with PP/RLAI can be switched to AL.
Vitamin D and skin: new aspects for dermatology (2004)

It has been shown that epidermal keratinocytes have the capacity for the UVB-induced photochemical conversion of 7-dehydrocholesterol to vitamin D3, and also for the enzymatically controlled hydroxylation of the photolysis product. This metabolic loop results in the formation of the biologically active final product 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3, calcitriol). The epidermal synthesis of calcitriol is of fundamental relevance because calcitriol regulates important cellular functions in keratinocytes and immunocompetent cells. Because of their anti-proliferative and prodifferentiating effects, calcitriol and other vitamin D analogs are highly efficient in the treatment of psoriasis vulgaris. In addition, the known therapeutic effect of UVB light therapy in the treatment of psoriasis may, at least in part, be mediated via UVB-induced synthesis of calcitriol. Increasing evidence now indicates that cutaneous vitamin D synthesis is of great importance for the prevention of a broad variety of diseases, including various malignancies. It has been postulated that cancer mortality could be reduced via careful UV exposure or, more safely, via oral substitution with vitamin D. These new findings must be taken into account when establishing new sun protection guidelines for the prevention of skin cancer. In addition, better understanding of the metabolism of vitamin D in the skin has opened up new perspectives for the therapeutic application of vitamin D analogs, e.g. in inflammatory skin diseases.