gebhart/patrepeval huggingface dataset:
A Comprehensive Analysis in Terms of Molecule-Intrinsic Quasi-Atomic Orbitals. IV. Bond Breaking and Bond Forming along the Dissociative Reaction Path of Dioxetane (2015)

The quantitative analysis of molecular density matrices in terms of oriented quasi-atomic orbitals (QUAOs) is shown to yield detailed conceptual insight into the dissociation of dioxetane on the basis of ab initio wave functions. The QUAOs persist and can be followed throughout the reaction path. The kinetic bond orders and the orbital populations of the QUAOs quantitatively reveal the changes of the bonding interactions along the reaction path. At the transition state the OO bond is broken, and the molecule becomes a biradical. After the transition state the reaction path bifurcates. The minimum energy path gently descends from the transition state via a valley-ridge inflection point to a second saddle point, from which two new minimum energy paths lead to two equivalent formaldehyde dimers. The CC bond breaks, and the π-bonds of the formaldehyde fragments form in close vicinity of the second saddle point. The changes of the interactions in this region are elucidated by the analysis of the rearrangements of the QUAOs.
Defect Reduction in Through Wafer Via Photolithography Processing (2006)

As customer requirements reduce the maximum product defects allowed to less than one part-per-million, identifying the source of the occasional defect during wafer processing becomes more challenging. We observed a defect on wafers we call “via rings”. This defect occurs when the street photoresist does not sufficiently protect the plated gold film at the top edge of the through wafer vias during the street etch process. This paper discusses the use of an additional step during the street resist coat process to ensure that the resist properly protects the edges of the vias during the etch process.
Analysis of Time-Dependent Flow-Sensitive PC-MRI Data (2011)

Many flow visualization techniques, especially integration-based methods, are problematic when the measured data exhibit noise and discretization issues. Particularly, this is the case for flow-sensitive phase-contrast magnetic resonance imaging (PC-MRI) data sets which not only record anatomic information, but also time-varying flow information. We propose a novel approach for the visualization of such data sets using integration-based methods. Our ideas are based upon finite-time Lyapunov exponents (FTLE) and enable identification of vessel boundaries in the data as high regions of separation. This allows us to correctly restrict integration-based visualization to blood vessels. We validate our technique by comparing our approach to existing anatomy-based methods as well as addressing the benefits and limitations of using FTLE to restrict flow. We also discuss the importance of parameters, i.e., advection length and data resolution, in establishing a well-defined vessel boundary. We extract appropriate flow lines and surfaces that enable the visualization of blood flow within the vessels. We further enhance the visualization by analyzing flow behavior in the seeded region and generating simplified depictions.
REDUCTION OF SUSCEPTIBILITY TO POROSITY DURING GAS-SHIELDED METAL-ARC WELDING BY MEANS OF PULSE-CONTROLLED ARCS (1986)

Tests to determine the effects of using a pulse-controlled arc for the gas-shielded metal-arc welding of carbon steel, austenitic chromium-nickel steel, and aluminium have shown that in all cases the amount of visible porosity in the seams was considerably reduced.
Traditional dishes of Britain [title page] (2025)

Introduction, Cornish pastry, Richmond maids of honour, the most wonderful fish in the sea, bakewell pudding, hindle wakes, Yorkshire pudding, shortbread, Lancashire hotpot, bread, scones, the buns of Britain, simnel cake, pancakes, steak and kidney pudding, muffins and crumpets, mincemeat.
Abstract 21495: The Utility of Exercise Stress Test in Predicting Coronary Plaque and Stenosis as detected by Coronary Computed Tomography Angiography: The ROMICAT Study (2010)

Background: Despite the recent adoption of advanced imaging techniques such as Coronary CT angiography (CTA) and myocardial perfusion imaging, exercise treadmill testing (ETT), remains an inexpensi...
The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma (2018)

Glioma-associated microglia/macrophages (Gam) represent an attractive therapeutic target for the development of the alternative methodology in the treatment of gliomas. this study was aimed to investigate the effect of intranasally administered TLR3 agonist Larifan on microglial cell metabolic profile in rats with c6 glioma. our results demonstrate progressive generation microglial cell population with immunosuppressive and pro-inflammatory properties in C6 glioma-bearing brain. Intranasally delivered TLR3 agonist is capable to abrogate the creation of this pro-tumoral immune infiltrates, probably, through the effect on myeloid-derived suppressor cells, and can be considered as a promising agent for glioma therapy aimed the Gam re-education. k e y w o r d s: glioma,
Hepatic abnormalities in patients with chronic granulomatous disease (2007)

Liver enzyme abnormalities occur frequently in patients with CGD. In addition to liver abscesses and granulomata, drug hepatotoxicity is likely underappreciated. Vascular lesions such as venopathy and--to a lesser extent--NRH are common. The cause and clinical consequences of venopathy await prospective evaluation.
Crystallization by settling in suspensions of hard spheres (1999)

We examine crystallization by settling for two different model hard-sphere suspensions. Sedimentation velocities, internal shock velocities, and crystal growth velocities are measured. Dynamic light scattering experiments measure volume fraction profiles in fluid phases, while Bragg scattering experiments determine volume fraction profiles in crystal phases. Centrifugation experiments determine the particle Péclet number above which samples will not crystallize. The sedimentation velocities, as a function of volume fraction, agree with other "hard-sphere" data. Remarkably, the value of the reduced crystal growth velocity (approximately 0.075) obtains for two orders of magnitude of the particle Péclet number. Kynch theory provides an adequate description of the data in the fluid phase, but is less adequate for volume fraction profiles in the crystal phase. The crystals in the dense sediment are compressed more along a vertical axis relative to the horizontal axis. Predicted Wilson-Frenkel crystal growth velocities, calculated using known hard-sphere equations of state and a short-time self-diffusion constant, rationalize the measured crystal growth velocities.
Preliminary studies for using magnetic resonance imaging systems as a mean of propulsion for microrobots in blood vessels and evaluation of ferromagnetic artefacts (2004)

A prototype for a magnetically controlled microrobot for applications in blood vessels is being developed. A strong and variable driving magnetic field exerts propulsion forces in three dimensions to a ferromagnetic core embedded onto the microrobot. Magnetic resonance imaging (MRI) systems are being considered as they provide the required magnetic fields and controls. Their imaging capabilities could also be used to track the displacements of the robots, providing position feedback informations. The paper describes tests made for spin echo and gradient echo sequences. They show that ferromagnetic materials cause imaging distortions (artefacts) several times larger than the size of the ferromagnetic core. It is critical to retrieve the robot's position from the distorted image but, the elimination or reduction of such ferromagnetic artefacts is currently a serious problem. Therefore, alternative solutions to the imaging problems like artefact cancelation or artefact pattern tracking softwares need to be developed.
Comparison Between Independent Component Analysis and Wiener-Hopf Filter Techniques for Eye Blink Removal (2020)

Electroencephalogram (EEG) is useful in the clinical diagnosis of various brain diseases. However, the existence of artifacts corrupting the EEG reduces the ability to do such a proper diagnosis. One of these unwanted signals is the eye blink. Therefore, pre-processing of the EEG is of great importance for proper diagnosis. This work compares between using the Independent component Analysis (ICA) and the Wiener filter techniques for removing eye blink (EB) artifacts from EEG. EEG datasets contaminated with EBs are used for quantifying the performance of the EB rejection methods. Mean squared error (MSE) is calculated and compared between the two methods. The Results show that the Wiener-Hopf filter gives better results in rejecting EBs and producing artifact-free EEG signal.
Prognosis of Women With Metastatic Breast Cancer by HER2 Status and Trastuzumab Treatment: An Institutional-Based Review (2009)

PURPOSE The purpose of this study was to determine whether trastuzumab improves prognosis of women with metastatic human epidermal growth factor receptor 2 (HER2)/neu -positive breast cancer beyond that of women with HER2/neu-negative disease. PATIENTS AND METHODS Two thousand ninety-one women with metastatic breast cancer diagnosed from 1991 to 2007, with known HER2/neu status and who had not received trastuzumab in the adjuvant setting, were identified. Disease was classified into the following three groups: HER2/neu negative, HER2/neu positive without first-line trastuzumab treatment, and HER2/neu positive with first-line trastuzumab treatment. Overall survival (OS) was estimated using the Kaplan-Meier product-limit method and compared between groups with the log-rank test. Cox proportional hazards models were used to determine associations between OS and HER2/neu status after controlling for patient characteristics. Results One hundred eighteen patients (5.6%) had HER2/neu-positive disease without trastuzumab treatment, 191 (9.1%) had HER2/neu-positive disease and received trastuzumab treatment, and 1,782 (85.3%) had HER2/neu-negative disease. Median-follow-up was 16.9 months. One-year survival rates among patients with HER2/neu-negative disease, HER2/neu-positive disease and trastuzumab treatment, and HER2/neu-positive disease and no trastuzumab treatment were 75.1% (95% CI, 72.9% to 77.2%), 86.6% (95% CI, 80.8% to 90.8%), and 70.2% (95% CI, 60.3% to 78.1%), respectively. In a multivariable model, women with HER2/neu-positive disease who received trastuzumab had a 44% reduction in the risk of death compared with women with HER2/neu-negative disease (hazard ratio [HR] = 0.56; 95% CI, 0.45 to 0.69; P < .0001). This HR varied with time and was significant for the first 24 months and not significant after 24 months. CONCLUSION Our results show that women with HER2/neu-positive disease who received trastuzumab had improved prognosis compared with women with HER2/neu-negative disease.
A microstrip array fed by a nonhomogeneous stripline feeding network (2002)

Using high-dielectric plugs instead of via-holes eliminates the need for ohmic contact, which sometimes is difficult to ensure in the vias. This technological process requires one less plating round which considerably reduces the price of the product. All the layers are simultaneously processed and bonded together in the same way stripline circuits are. A 4/spl times/4 microstrip array fed by a feeding network which makes use of this new technology was built and tested. The implementation of this technique at 66 GHz is being considered.
B-Cache: A Behavior-Level Caching Framework for the Programmable Data Plane (2018)

By enabling operators to program behaviors of the packet processing pipeline, P4, a domain-specific language, unleashes new opportunities for offloading network functions onto the programmable data plane (PDP) and enhancing network performance. However, recent research shows that as P4 programs and the corresponding packet processing pipeline grow in size and complexity, the performance of the PDP will decrease significantly, which compromises the programmability and flexibility brought by P4. To overcome this performance degradation, we propose B-Cache, a general behavior-level caching framework for both stateful and stateless behaviors on the PDP. The basic idea of B-Cache is to compile packet processing behaviors that were once distributed across multiple tables into one synthetic cache table, thus guarantee the performance on various P4 targets. Our experiment results indicate that B-Cache comparably yields significant performance benefits including a 49% delay decrease and a 200% throughput increase on the software target, and a 60% throughput increase on the hardware target.
Implementation and evaluation of a time-driven scheduling processor (2003)

C.D. Locke developed a heuristic, best-effort (BE) time-driven scheduling policy (Ph.D. thesis, Dept. of Comput. Sci., Carnegie-Mellon Univ., (1986)) and demonstrated its superiority to simpler policies using extensive simulations. The author describes an implementation of Locke's BE policy that uses a dedicated scheduling processor to reduce the scheduling overhead significantly. The scheduler was implemented in the Mach operating system kernel, running on a VAX 11/784 multiprocessor. Experimental results under synthetic real-time processing loads of varying intensity show that the high computational overheads of the BE policy make it impractical on a uniprocessor system. Under heavy loads, over 80% of the processors's time can be spent in the scheduler, deciding which task to run next. Using the scheduling processor, less than 2% of the host processor's time is spent in the scheduler.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Bacterial lipopolysaccharide-induced interferon-gamma production: roles of interleukin 1 and interleukin 2. (1986)

Bacterial lipopolysaccharide (LPS) induced human peripheral blood mononuclear cells (PBMC) to produce interferon-gamma (IFN-gamma). Monocytes play a mandatory accessory role in this process, because purified T lymphocytes failed to produce IFN-gamma in response to LPS and the addition of 2% monocytes to T cell cultures resulted in an optimal LPS-induced IFN-gamma production. IFN-gamma production was abolished in the presence of monoclonal antibodies specific for HLA-DR antigen. Addition of exogenous interleukin 2 (IL 2) markedly enhanced IFN-gamma secretion by PBMC induced with LPS. The addition of anti-Tac antibody specific for IL 2 receptors abrogated IFN-gamma production, suggesting that an interaction of IL 2 with IL 2 receptors was involved. By using a specific antibody binding assay, LPS was shown to amplify IL 2 receptor expression on PBMC, whereas exogenous IL 2 showed only a negligible enhancing effect on the expression of its own receptors. Interleukin 1 (IL 1), a product of LPS-stimulated monocytes, potentiated IL 2-induced IFN-gamma production in the absence of LPS. Neither IL 1 nor IL 2 alone induced IFN-gamma production in purified T lymphocyte cultures. When added together, however, substantial levels of IFN-gamma were induced. An enhanced IL 2 receptor expression on T cells was also demonstrated as a result of the combined action of IL 1 and IL 2. These results suggest that induction of IFN-gamma by LPS is due mainly to the generation of IL 1 and an enhanced expression of IL 2 receptors.
Observation and analysis of the temperature changes in nursing of patients with lumbar post-operation (2009)

Objective To study the temperature changes in lumbar post-operation, which is helpful for nurses to find out abnormal behaviors of patients and the related reasons on time. Methods The temperature, blood and urine routine of 101 patients with lumbar operation were analyzed for 1 day pre-operafion, the day on operation, and 3～5 days post-operation. Results Basic temperature was compared to mean temperature of 3 days post-operation, 24 hours post-decannulation and 3 days post-decannulation. Data analysis showed significant difference among basic temperature and those mean temperatures (P<0.01). Conclusions The temperature changes after operation and decannulation are important. This issue might be stressed in the future nursing education.

Key words: 
Lumbar vertebrae;  Care, postoperative;  Body temperature changes
Some Amide Derivatives of Certain Aminomethylpyridines (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Amide Derivatives of Certain AminomethylpyridinesJohn D. Sculley and Cliff S. HamiltonCite this: J. Am. Chem. Soc. 1953, 75, 14, 3400–3403Publication Date (Print):July 1, 1953Publication History Published online1 May 2002Published inissue 1 July 1953https://pubs.acs.org/doi/10.1021/ja01110a030https://doi.org/10.1021/ja01110a030research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ancient gene linkages support ctenophores as sister to other animals (2023)

A central question in evolutionary biology is whether sponges or ctenophores (comb jellies) are the sister group to all other animals. These alternative phylogenetic hypotheses imply different scenarios for the evolution of complex neural systems and other animal-specific traits<sup>1-6</sup>. Conventional phylogenetic approaches based on morphological characters and increasingly extensive gene sequence collections have not been able to definitively answer this question<sup>7-11</sup>. Here we develop chromosome-scale gene linkage, also known as synteny, as a phylogenetic character for resolving this question<sup>12</sup>. We report new chromosome-scale genomes for a ctenophore and two marine sponges, and for three unicellular relatives of animals (a choanoflagellate, a filasterean amoeba and an ichthyosporean) that serve as outgroups for phylogenetic analysis. We find ancient syntenies that are conserved between animals and their close unicellular relatives. Ctenophores and unicellular eukaryotes share ancestral metazoan patterns, whereas sponges, bilaterians, and cnidarians share derived chromosomal rearrangements. Conserved syntenic characters unite sponges with bilaterians, cnidarians, and placozoans in a monophyletic clade to the exclusion of ctenophores, placing ctenophores as the sister group to all other animals. The patterns of synteny shared by sponges, bilaterians, and cnidarians are the result of rare and irreversible chromosome fusion-and-mixing events that provide robust and unambiguous phylogenetic support for the ctenophore-sister hypothesis. These findings provide a new framework for resolving deep, recalcitrant phylogenetic problems and have implications for our understanding of animal evolution.
Electrocardiographic Events Preceding Onset of Atrial Fibrillation: Insights Gained Using an Implantable Loop Recorder (2006)

Using the ILR, serial, long-term characterization of electrocardiographic events preceding AF onset was feasible, and typically demonstrated a varied pattern within individuals. There was significant incongruity between symptomatic and electrocardiographic AF burden. As described here, ILR technology is inadequate for the purpose of accurate characterization of AF burden.
Isolation and characterization of equine native MSC populations (2017)

This study reports for the first time the successful isolation and culture of CD146<sup>+</sup> and CD34<sup>+</sup> cell populations from equine tissues. Characterization of these cells evidenced their distinct properties and MSC-like phenotype, and identified CD146<sup>+</sup> cells as distinctly angiogenic, which may provide a novel source for enhanced regenerative therapies.
Parasellar Chronic Inflammatory Disease Presenting Tolosa-Hunt Syndrome, Hypopituitarism and Diabetes Insipidus: A Case Report. (1996)

We describe a 60-year-old man with a history of Tolosa-Hunt syndrome associated with intermittent painful ophthalmoplegia and a visual disturbance on the left side, who presented with signs and symptoms of severe hypoadrenalism and diabetes insipidus. Magnetic resonance imaging demonstrated enlargement of the hypophysis and infundibulum and left cavernous sinus. An endocrinologic study revealed anterior pituitary dysfunction and diabetes insipidus. The patient underwent a transsphenoidal biopsy which revealed chronic inflammation in the hypophysis, mucosa of the sphenoid sinus, and dura mater. The patient was treated with steroids that decreased the size of the hypophysis and infundibulum, but the symptoms of anterior pituitary insufficiency and diabetes insipidus have persisted. The chronic inflammation of the hypophysis and infundibulum is thought to have spread from the cavernous sinus.
Dynamic Segment Repackaging at the Edge for HTTP Adaptive Streaming (2020)

Adaptive video streaming systems typically support different media delivery formats, e.g., MPEG-DASH and HLS, replicating the same content multiple times into the network. Such a diversified system results in inefficient use of storage, caching, and bandwidth resources. The Common Media Application Format (CMAF) emerges to simplify HTTP Adaptive Streaming (HAS), providing a single encoding and packaging format of segmented media content and offering the opportunities of bandwidth savings, more cache hits, and less storage needed. However, CMAF is not yet supported by most devices. To solve this issue, we present a solution where we maintain the main advantages of CMAF while supporting heterogeneous devices using different media delivery formats. For that purpose, we propose to dynamically convert the content from CMAF to the desired media delivery format at an edge node. We study the bandwidth savings with our proposed approach using an analytical model and simulation, resulting in bandwidth savings of up to 20% with different media delivery format distributions. We analyze the runtime impact of the required operations on the segmented content performed in two scenarios: (i) the classic one, with four different media delivery formats, and (ii) the proposed scenario, using CMAF-only delivery through the network. We compare both scenarios with different edge compute power assumptions. Finally, we perform experiments in a real video streaming testbed delivering MPEG-DASH using CMAF content to serve a DASH and an HLS client, performing the media conversion for the latter one.