gebhart/patrepeval huggingface dataset:
Active Regulation of Insect Respiration (1999)

Journal Article Active Regulation of Insect Respiration Get access Karel Sláma Karel Sláma Institute of Entomology, Czech Academy of Sciences, Drnovská 507, Praha 6, 16100 Czech Republic. Search for other works by this author on: Oxford Academic Google Scholar Annals of the Entomological Society of America, Volume 92, Issue 6, 1 November 1999, Pages 916–929, https://doi.org/10.1093/aesa/92.6.916 Published: 01 November 1999 Article history Received: 23 November 1998 Accepted: 11 May 1999 Published: 01 November 1999
Supplementary Figures 1-6 from Single-Cell Transcriptomics Analysis Identifies Nuclear Protein 1 as a Regulator of Docetaxel Resistance in Prostate Cancer Cells (2023)

&lt;p&gt;Supplementary Figure 1: Cell outlier removal. Supplementary Figure 2: Gene Expression Profiles. Supplementary Figure 3: Technical Variation in DU145 clusters. Supplementary Figure 4: Upstream Regulator Analyses in Bulk Sequencing Samples. Supplementary Figure 5: Comparison of NUPR1 Target Gene Expression between Single Cell and Bulk Sequencing Samples. Supplementary Figure 6: NUPR1 necessary for docetaxel resistance in PC3 cells.&lt;/p&gt;
Task Allocation and Precedence Relations for Distributed Real-Time Systems (1987)

In a distributed processing system with the application software partitioned into a set of program modules, allocation of those modules to the processors is an important problem. This paper presents a method for optimal module allocation that satisfies certain performance constraints. An objective function that includes the intermodule communication (IMC) and accumulative execution time (AET) of each module is proposed. It minimizes the bottleneck-processor utilization—a good principle for task allocation. Next, the effects of precedence relationship (PR) among program modules on response time are studied. Both simulation and analytical results reveal that the program-size ratio between two consecutive modules plays an important role in task response time. Finally, an algorithm based on PR, AET, and IMC and on the proposed objective function is presented. This algorithm generates better module assignments than those that do not consider the PR effects.
Supplementary Figure S6 from Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development <i>In Vivo</i> (2023)

&lt;p&gt;High magnification pmCiC staining (Fig. 5C) of benign prostate epithelial cells versus cancer cells.&lt;/p&gt;
Polarimetric radar remote sensing of ocean surface wind (2002)

Experimental data are presented to support the development of a new concept for ocean wind velocity measurement (speed and direction) with the polarimetric microwave radar technology. This new concept has strong potential for improving the wind direction accuracy and extending the useful swath width by up to 30% for follow-on NASA spaceborne scatterometer mission to SeaWinds series. The key issue is whether there is a relationship between the polarization state of ocean backscatter and surface wind velocity at NASA scatterometer frequencies (13 GHz). An airborne Ku-band polarimetric scatterometer (POLSCAT) was developed for proof-of-concept measurements. A set of aircraft flights indicated repeatable wind direction signals in the POLSCAT observations of sea surfaces at 9-11 m/s wind speed. The correlation coefficients between co- and cross-polarized radar response of ocean surfaces have a peak-to-peak amplitude of about 0.4 and are shown to have an odd-symmetry with respect to the wind direction, unlike the normalized radar cross sections.
Serum MicroRNAs in HIV-Infected Individuals as Pre-Diagnosis Biomarkers for AIDS-NHL (2014)

Altered serum levels of miR-21, miR-122, and miR-223 are seen in HIV-infected individuals. Higher serum level of miR-222 has clear potential as a serum biomarker for earlier detection of DLBCL and PCNSL among HIV-infected individuals.
Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice. (2014)

Tumor blood vessels are leaky and immature, which causes inadequate blood supply to tumor tissues resulting in hypoxic microenvironment and promotes metastasis. Here we have explored tumor vessel modulating activity of Sac-1004, a recently developed molecule in our lab, which directly potentiates VE-cadherin-mediated endothelial cell junction. Sac-1004 could enhance vascular junction integrity in tumor vessels and thereby inhibit vascular leakage and enhance vascular perfusion. Improved perfusion enabled Sac-1004 to have synergistic anti-tumor effect on cisplatin-mediated apoptosis of tumor cells. Interestingly, characteristics of normalized blood vessels namely reduced hypoxia, improved pericyte coverage and decreased basement membrane thickness were readily observed in tumors treated with Sac-1004. Remarkably, Sac-1004 was also able to inhibit lung and lymph node metastasis in MMTV and B16BL6 tumor models. This was in correlation with a reduction in epithelial-to-mesenchymal transition of tumor cells with considerable diminution in expression of related transcription factors. Moreover, cancer stem cell population dropped substantially in Sac-1004 treated tumor tissues. Taken together, our results showed that direct restoration of vascular junction could be a significant strategy to induce normalization of tumor blood vessels and reduce metastasis.
Rational design of a scytalone dehydratase-like enzyme using a structurally homologous protein scaffold (1999)

The generation of enzymes to catalyze specific reactions is one of the more challenging problems facing protein engineers. Structural similarities between the enzyme scytalone dehydratase with nuclear transport factor 2 (NTF2) suggested the potential for NTF2 to be re-engineered into a scytalone dehydratase-like enzyme. We introduced four key catalytic residues into NTF2 to create a scytalone dehydratase-like active site. A C-terminal helix found in scytalone dehydratase but absent in NTF2 also was added. Mutant NTF2 proteins were tested for catalytic activity by using a spectroscopic assay. One of the engineered enzymes exhibited catalytic activity with minimal kcat and Km values of 0.125 min-1 and 800 microM, respectively. This level of catalytic activity represents minimally a 150-fold improvement in activity over the background rate for substrate dehydration and a dramatic step forward from the catalytically inert parent NTF2. This work represents one of the few examples of converting a protein scaffold into an enzyme, outside those arising from the induction of catalytic activity into antibodies.
A multi-centre study of the efficacy and safety of pravastatin in hypercholesterolaemic patients with non-insulin-dependent diabetes mellitus (1994)

A multi-centre, non-randomized clinical study of 12-months' duration was performed in 112 patients with hyperlipidaemia associated with non-insulin-dependent diabetes mellitus to evaluate the clinical efficacy and tolerability of pravastatin and to assess its effect on glycaemic control. Patients were eligible for this trial if they fulfilled the following criteria; a high plasma total cholesterol level greater than 220 mg/dl associated with stable glycaemic control for at least 3-months' observation period. On entry, patients received 10 mg pravastatin per day (5 mg twice daily) for 12 months. Clinical efficacy was evaluated in 108 patients. The results showed that pravastatin induced a significant decrease in serum cholesterol level mainly with LDL-cholesterol. Total cholesterol levels were decreased significantly from 275 +/- 3 mg/dl to 222 +/- 4 mg/dl within 3 months of the start of treatment, and LDL-cholesterol decreased from 192 +/- 4 mg/dl to 137 +/- 4 mg/dl. After 12 months' treatment, total cholesterol and LDL-cholesterol levels were 216 +/- 4 mg/dl (p < 0.001) and 137 +/- 5 mg/dl (p < 0.001), respectively. HDL-cholesterol levels were increased from 51 +/- 2 mg/dl to 56 +/- 2 mg/dl at 3 months (p < 0.001) and 55 +/- 2 mg/dl at 12 months (p < 0.01). Triglyceride concentrations were also decreased from 173 +/- 11 mg/dl to 156 +/- 13 mg/dl at 3 months and 137 +/- 10 mg/dl at 12 months (p < 0.01). Fasting plasma glucose and glycated haemoglobin levels were not affected by pravastatin. Adverse events observed in 5 cases were always mild and reversible. These results indicate a clinical usefulness of pravastatin with high compliance in patients with hyperlipidaemia associated with non-insulin-dependent diabetes mellitus.
Arch-trapped propagation in enclosed and free space biological objects (2018)

The tendency of arch-trapped microwave propagation at curved surfaces is a kind of diffraction which needs more attention in the development of measurement systems, from the oil industry to the investigations using antenna applicator systems for biological objects. We develop equations for propagation in very Iossy substances in metal pipes. Similar such propagation occurs at the periphery of rounded objects in air, where also surface wave effects occur and can cause measurement problems. We show a modified contacting antenna applicator minimizing arch-trapped as well as surface waves.
Flow-Based Anomaly Detection Using Neural Network Optimized with GSA Algorithm (2013)

Reliable high-speed networks are essential to provide quality services to ever growing Internet applications. A Network Intrusion Detection System (NIDS) is an important tool to protect computer networks from attacks. Traditional packet-based NIDSs are time-intensive as they analyze all network packets. A state-of-the-art NIDS should be able to handle a high volume of traffic in real time. Flow-based intrusion detection is an effective method for high speed networks since it inspects only packet headers. The existence of new attacks in the future is another challenge for intrusion detection. Anomaly-based intrusion detection is a well-known method capable of detecting unknown attacks. In this paper, we propose a flow-based anomaly detection system. Artificial Neural Network (ANN) is an important approach for anomaly detection. We used a Multi-Layer Perceptron (MLP) neural network with one hidden layer. We investigate the use of a Gravitational Search Algorithm (GSA) in optimizing interconnection weights of a MLP network. Our proposed GSA-based flow anomaly detection system (GFADS) is trained with a flow-based data set. The trained system can classify benign and malicious flows with 99.43% accuracy. We compare the performance of GSA with traditional gradient descent training algorithms and a particle swarm optimization (PSO) algorithm. The results show that GFADS is effective in flow-based anomaly detection. Finally, we propose a four-feature subset as the optimal set of features.
Palladium-catalyzed arylation of allylic alcohols with aryl halides (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPalladium-catalyzed arylation of allylic alcohols with aryl halidesJohn B. Melpolder and Richard F. HeckCite this: J. Org. Chem. 1976, 41, 2, 265–272Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://doi.org/10.1021/jo00864a017Request reuse permissionsArticle Views3655Altmetric-Citations228LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (951 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Raman spectra of GexAsySe1−x−y glasses (2009)

Various Ge–As–Se glasses spanning a mean coordination number (MCN) from 2.2 to 2.94 have been investigated using differential scanning calorimetry and Raman spectroscopy. The glass transition temperature Tg was found to increase with increasing MCN, except for those glasses located within the nanoscale phase-separated region of the phase diagram. The evolution of Raman features at wavenumbers from 150 to 350 cm−1 exhibits two transitionlike features. Merging of the 225 and 250 cm−1 modes at MCN=2.5 is a symbol of the extinction of Se–Se bonds. Additionally, the appearance of two modes at 280–290 and 170 cm−1 at MCN&amp;gt;2.7 come from the defect modes of ethanelike Ge2Se6/2. The increase in the scattering from these defects is an important factor leading to enhanced optical loss in the glasses with high MCN.
ChemInform Abstract: Preparation and Structure of Manganese Molybdates. (1986)

Abstract Manganese molybdates are prepared by precipitation from aqueous solutions of Na 2 MoO 4 ‐2 H 2 O with l M MnSO 4 ‐ H 2 O at various pH.
User assisted stereo image segmentation (2012)

The wide availability of stereoscopic 3D displays created a considerable market for content producers. This encouraged researchers to focus on methods to alter and process the content for various purposes. This study concentrates on user assisted image segmentation and proposes a method to extend previous techniques on monoscopic image segmentation to stereoscopic footage with minimum effort. User assistance is required to indicate the representative locations of an image as object and background regions. An MRF based energy minimization technique is utilized where user inputs are applied only on one of the stereoscopic pairs. A key contribution of the proposed study is the elimination of dense disparity estimation by introducing a sparse feature matching idea. Segmentation results are evaluated by objective metrics on a ground truth stereo segmentation dataset and it can be concluded that competitive results with minimum user interaction have been obtained even without dense disparity estimation.
Butyrate-Induced Transcriptional Changes in Human Colonic Mucosa (2009)

Colonic administration of butyrate in concentrations that can be achieved by consumption of a high-fiber diet enhances the maintenance of colonic homeostasis in healthy subjects, by regulating fatty acid metabolism, electron transport and oxidative stress pathways on the transcriptional level and provide for the first time, detailed molecular insight in the transcriptional response of gut mucosa to butyrate.
Pass-by noise acoustic sensing for estimating speed and wheelbase length of two-axle vehicles. (2013)

This paper focuses on acoustic road traffic monitoring and looks, more specifically, into the problem of joint speed and wheelbase length estimation of two-axle vehicles as they pass by. It is known that both front and rear axle trajectories may be observed using a cross-correlation based processing in conjunction with a well designed two-element microphone array placed on the roadside. This is mainly due to the broadband nature of the tyre/road noise which makes two peaks appear in, one per axle, in the correlation function. In a former work, we proposed to conduct this double-peak-tracking problem using a specific particle filter that model road vehicles as bimodal sound sources (bimodal particle filter). After a brief theoretical recall of the method, this paper stresses on the recent preliminary results we obtained from simulation and in-situ experiments.
Next Generation Munitions Handler: Human-Machine Interface and Preliminary Performance Evaluation (1999)

The Next Generation Munitions Handler/Advanced Technology Demonstrator (NGMI-VATTD) is a technology demonstrator for the application of an advanced robotic device for re-arming U.S. Air Force (USAF) and U.S. Navy (USN) tactical fighters. It comprises two key hardware components: a heavy-lift dexterous manipulator (HDM) and a nonholonomic mobility platform. The NGMWATTD is capable of lifting weapons up to 4400 kg (2000 lb) and placing them on any weapons rack on existing fighters (including the F-22 Raptor). This report describes the NGMH mission with particular reference to human-machine interfaces. It also describes preliminary testing to garner feedback about the heavy-lift manipulator arm from experienced fighter load crewmen. The purpose of the testing was to provide preliminary information about control system parameters and to gather feed- back from users about manipulator arm functionality. To that end, the Air Force load crewmen interacted with the NGMWATTD in an informal testing session and provided feedback about the performance of the system. Certain con- trol system parameters were changed during the course of the testing and feedback from the participants was used to make a rough estimate of "good" initial operating parameters. Later, formal testing will concentrate within this range to identify optimal operating parameters. User reactions to the HDM were generally positive, All of the USAF personnel were favorably impressed with the capabilities of the system. Fine-tuning operating parameters created a system even more favorably regarded by the load crews. Further adjustment to control system parameters will result in a system that is operationally efficient, easy to use, and well accepted by users.
Side effect profile and adherence to in the treatment of Multiple Sclerosis with interferon beta-la (1998)

This study examines the course of patient-reported side effects during the first 4 months of treatment for multiple sclerosis (MS) with interferon beta-1a (IFN beta-1a), and the relationship of those side effects to discontinuation of medication. Flu-like symptoms, muscle aches and chills decreased over the first 2 months of treatment but did not change over the second 2 months. Loss of feeling or numbness, tingling and depression increased over 4 months, however these side effects were generally mild. Loss of feeling or numbness and tingling at 2 month follow-up were significantly related to discontinuation of IFN beta-1a by 4 month follow-up.
Driving the Deployment of Citywide Ubiquitous WiFi Access (2007)

Cost-efficiency is a critical factor for citywide deployments of WiFi networks that are being planned by telecom operators and governments around the world. Building such networks by reusing the broadband infrastructure, currently used only by the mass costumer at home, is an attractive approach to follow. We tackle the problem of selecting locations from the existing broadband infrastructure to build such an overlay WiFi access network. We use an algorithm that solves the budgeted version of the Maximum Coverage Problem to select hotspot deployment points out of the available ones in an area. These points represent premises of the broadband customers where hotspots can be installed. The hotspots are placed in such a way that the connectivity demand in the given deployment area is satisfied at the lowest possible cost. The proposed algorithm is assessed by simulations, applying it to random and real datasets representing access demand, geographical distributions, and locations where hotspots can be deployed. The key findings of this study are: The connectivity demand can be satisfied by the coverage at a cost growing faster than linearly. In fact, the cost of covering the first 85 % of the demand is as much as 1/4 of the one needed to satisfy it fully. Additionally, the current broadband penetration in cities, like Berlin, makes WiFi access almost ubiquitous with an average distance between nomadic users and hotspots of 200 m. Christopher Thraves is currently affiliated, as PhD student,
The monitoring system of DoS/DDoS attacks in the global network (2011)

In this article we created the mathematical model of “client to server” communication including the compromised node probabilities and a number of possible routes having an admission to access points, also comparative characteristics of DoS/DDoS attacks in computer network has been provided herewith.
Effects of particle size distribution in thick film conductors (1983)

We isolated cDNAs encoding xanthine dehydrogenase (XD; xanthine:NAD+ oxidoreductase, EC 1.1.1.204) from a human liver cDNA library. The complete nucleotide sequence of human XD was determined; the deduced amino acid sequence encoded a protein of 1336 amino acid residues of M(r) 147,782. Human XD possessed many of the signature sequences typical of XDs from flies and rodents, including an unusual cysteine distribution, a potential 2Fe/2S binding site, and a putative molybdopterin cofactor binding domain. Analysis of potential NAD binding sites suggested a simple hypothesis for the conversion of human XD into the oxygen metabolite forming xanthine oxidase (XO; xanthine:oxygen oxidoreductase, EC 1.1.3.22). Using a human XD complementary RNA hybridization probe, we found a 5100-base RNA in human liver by RNA blot-hybridization analysis. This RNA exhibited tissue-specific distribution that may be pertinent to XD- and XO-mediated oxygen radical injury in ischemia/reperfusion and inflammation. A second 4500-base RNA was detected in some tissues and may arise through differential transcription termination.
Validation of presentation and 3 h high-sensitivity troponin to rule-in and rule-out acute myocardial infarction (2016)

The ESC-rule-in algorithm has good PPV with hs-cTnI and reasonable with hs-cTnT and can rule-in over 50% of AMIs. However, the sensitivity of the 99th percentile to rule-out AMI is too low for clinical use.
Stimulation of Phosphatidylinositol-4-phosphate 5-Kinase by Rho-Kinase (2000)

The serine/threonine kinase Rho-kinase was recently identified as a downstream effector of the small GTPase Rho, mediating effects of Rho on the actin cytoskeleton. Also phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) has been implicated in the regulation of actin polymerization. As the synthesis of PI(4,5)P(2) has been suggested to be affected by Rho proteins, we investigated whether Rho-kinase is involved in the control of PI(4,5)P(2) levels. Overexpression of RhoA in HEK-293 cells increased phosphatidylinositol 4-phosphate (PI4P) 5-kinase activity and concomitantly enhanced cellular PI(4,5)P(2) levels, whereas overexpression of the Rho-inactivating C3 transferase decreased both PI4P 5-kinase activity and PI(4,5)P(2) levels. These effects of RhoA could be mimicked by overexpression of wild-type Rho-kinase and of the constitutively active catalytic domain of Rho-kinase, Rho-kinase-CAT. In contrast, a kinase-deficient mutant of Rho-kinase had no effect on PI4P 5-kinase activity. Importantly, the increase in PI4P 5-kinase activity and PI(4,5)P(2) levels by wild-type Rho-kinase, but not by Rho-kinase-CAT, was completely prevented by coexpression of C3 transferase, indicating that the effect of Rho-kinase was under the control of endogenous Rho. In cell lysates, addition of recombinant RhoA and Rho-kinase-CAT stimulated PI4P 5-kinase activity. Finally, the increase in PI(4,5)P(2) levels induced by both Rho-kinase-CAT and RhoA was reversed by the Rho-kinase inhibitor HA-1077. Our data suggest that Rho-kinase is involved in the Rho-controlled synthesis of PI(4,5)P(2) by PI4P 5-kinase.
A Method for Collecting the Honey-Sac Contents from Honeybees (1976)

SummaryA simple method is described for collecting the honey-sac contents from honeybees. Captured foraging bees are anaesthetized with C02; the abdomen is squeezed in a special apparatus, which is described, to express the contents of the honey sac through the mouthparts. The expressed liquid is collected in a glass capillary tube and sealed and frozen for analysis later. Nectar loads can be collected very quickly, enabling large-scale studies to be made.The ingestion of fluid into the ventriculus is discussed.