gebhart/patrepeval huggingface dataset:
Tissue-type plasminogen activator and the low-density lipoprotein receptor–related protein induce Akt phosphorylation in the ischemic brain (2008)

Tissue-type plasminogen activator (tPA) is found in the intravascular space and in the central nervous system. The low-density lipoprotein receptor-related protein (LRP) is expressed in neurons and in perivascular astrocytes. During cerebral ischemia, tPA induces the shedding of LRP's extracellular domain from perivascular astrocytes, and this is followed by the development of cerebral edema. Protein kinase B (Akt) is a serine/threonine kinase that plays a critical role not only in cell survival but also in the regulation of the permeability of the blood-brain barrier. We found that, in the early phases of the ischemic insult, the interaction between tPA and LRP induces Akt phosphorylation (pAkt) in perivascular astrocytes and inhibits pAkt in neurons. Coimmunoprecipitation studies indicate that pAkt and LRP's intracellular domain interact in perivascular astrocytes and that this interaction is dependent on the presence of tPA and results in the development of edema. Together, these results indicate that, in the early stages of cerebral ischemia, the interaction between tPA and LRP in perivascular astrocytes induces the activation of a cell signaling event mediated by pAkt that leads to increase in the permeability of the blood-brain barrier.
Effect of spin excitations with simultaneous magnetic- and electric-dipole character on the static magnetoelectric properties of multiferroic materials (2014)

We derive a sum rule to demonstrate that the static magnetoelectric (ME) effect is governed by optical transitions that are simultaneously excited by the electric and magnetic components of light. The ME sum rule is applicable to a broad class of materials lacking the spatial inversion and the time-reversal symmetries, including multiferroic compounds. Due to the dynamical ME effect, the optical excitations in these materials can exhibit directional dichroism, i.e., the absorption coefficient can be different for counter-propagating light beams. According to the ME sum rule, the magnitude of the linear ME effect of a material is mainly determined by the directional dichroism of its low-energy optical excitations. An application of the sum rule to the multiferroic ${\mathrm{Ba}}_{2}$${\mathrm{CoGe}}_{2}$${\mathrm{O}}_{7}$, ${\mathrm{Sr}}_{2}$${\mathrm{CoSi}}_{2}$${\mathrm{O}}_{7}$, and ${\mathrm{Ca}}_{2}$${\mathrm{CoSi}}_{2}$${\mathrm{O}}_{7}$ shows that in these compounds the static ME effect is mostly governed by the directional dichroism of the spin-wave excitations in the giga-terahertz spectral range. On this basis, we argue that the studies of directional dichroism and the application of the ME sum rule promote the synthesis of new materials with large static ME effect.
Physical Association with Ras Enhances Activation of Membrane-bound Raf (RafCAAX) (1997)

The transforming activity of artificially membrane-targeted Raf1 suggests that Ras-mediated recruitment of Raf1 to the plasma membrane is an important step in Raf1 activation. Cellular Ras is concentrated in the caveolae, a microdomain of the plasma membrane that is highly enriched in caveolin, glycosylphosphatidylinositol-anchored proteins, and signal transduction molecules. Growth factor stimulation recruits Raf1 to this membrane domain. Whether Ras simply promotes Raf1 association with caveolae membranes or also modulates subsequent activation events is presently unclear. We have identified a ras variant, ras12V,37G, that does not interact with Raf1 but does interact with a mutant raf1, raf1(257L). To examine the role of Ras in the activation of membrane-bound Raf1, raf1CAAX, and raf1(257L)CAAX, membrane-targeted variants of Raf1 and raf1(257L), respectively, were expressed in fibroblasts with or without coexpression of ras12V, 37G. Cell fractionation localized both raf1CAAX and raf1(257L)CAAX to caveolae membranes independent of ras12V,37G expression; however, coexpression of ras12V,37G enhanced the activation of raf(257L)CAAX, but not raf1CAAX, as monitored by induction of cellular transformation, increased Raf kinase activity, and induction of activated MAP kinase. These results suggest that the Ras/Raf1 interaction plays a role in Raf1 activation that is distinct from membrane recruitment.
Improving thermal stability of hard coating films via a concept of multicomponent alloying (2011)

We propose a design route for the next generation of nitride alloys via a concept of multicomponent alloying based on self-organization on the nanoscale via a formation of metastable intermediate products during the spinodal decomposition. We predict theoretically and demonstrate experimentally that quasi-ternary (TiCrAl)N alloys decompose spinodally into (TiCr)N and (CrAl)N-rich nanometer sized regions. The spinodal decomposition results in age hardening, while the presence of Cr within the AlN phase delays the formation of a detrimental wurtzite phase leading to a substantial improvement of thermal stability compared to the quasi-binary (TiAl)N or (CrAl)N alloys.
Homonuclear radio frequency-driven recoupling in rotating solids (1998)

We discuss several aspects of homonuclear recoupling and longitudinal exchange using rotor-synchronized spin echo sequences in solid state magic-angle spinning (MAS) experiments. These include the accurate measurement of weak dipole–dipole couplings between rare spins, the behavior of dipolar trajectories in multiple spin environments, and chemical shift correlation spectroscopy via polarization exchange. To describe dipolar trajectories accurately, we adopt an approach to the simulation of these experiments which includes finite pulses and the influence of coherence decay. The latter effect becomes competitive with the strength of weak couplings in many experiments, and a simple empirical approach is outlined for the selection of decay parameters. Dipolar trajectories are shown to be dominated by the largest couplings in multiple spin systems via comparison of two and three interacting spins. Two-dimensional correlation spectroscopy based on dipolar exchange among proximate nuclei is illustrated with a uniformly N15,C13-labeled sample of the tetrapeptide achatin-II (Gly-L-Phe-L-Ala-L-Asp). In addition, a frequency-selective approach to recoupling dipolar interactions among homonuclear spins is introduced; selective approaches have possible utility in examining weak dipole–dipole couplings in the presence of strong interactions.
Ageing and Fertility (1985)

To examine whether fecundity is affected by age, peripheral oestradiol (E2) measurement and reproductive potential were studied in patients in different age groups receiving ovulation induction prior to in vitro fertilization (IVF) and embryo transfer (ET). The term pregnancy rate of 179 patients who had reversal of sterilization following 4 different sterilization procedures was also assessed in similar age groups. In the IVF group, age did not influence maximal E2 rise prior to oocyte retrieval, number of oocytes available for fertilization, fertilization rate, miscarriage or clinical pregnancy rate up to the age of 40. Similarly, in the reversal of sterilization group, term pregnancy rate was not affected by age, but was affected by the method of sterilization originally performed.We conclude from this study that IVF and reversal of sterilization procedures may be successful in women in the later reproductive age group.
미국의 고부담 시험의 가능성과 한계 (2010)

이 연구는 시험의 결과가 수험자의 인생을 바꿀 정도로 중요한 결정을 내리는데 활용되는 시험제도를 가지고 있는 미국의 고부담 시험의 가능성과 한계를 논의하는 것이다. 이를 위해 우선 고부담 시험의 의미를 고찰하고, 고부담 시험의 기원과 역사를 개관하였다. 그 후에 고부담 시험의 가능성과 한계를 검토하고, 마지막으로 우리나라에서의 바람직한 시험의 방향 정립을...
Identification of Kv11.1 Isoform Switch as a Novel Pathogenic Mechanism of Long-QT Syndrome (2014)

Our findings indicate that the IVS9-2delA mutation causes a switch in the expression of the functional Kv11.1a isoform to the nonfunctional Kv11.1a-USO isoform. Kv11.1 isoform switch represents a novel mechanism in the pathogenesis of long-QT syndrome.
Radial error propagation issues in self servo track writing technology (2003)

Summary form only given. A typical servo track writer employs an external radial positioning device such as a laser interferometer to guide the VCM to a known radial position. In this process, the head is prone to external vibration and has poor disturbance rejection. An alternative to the external positioner is self-radial propagation (Cribbs, Patent US5448429, 1996). This paper analyzed the radial error propagation in the process and algorithm for error containment.
Lipopolysaccharide- and Cholera Toxin-Specific Subclass Distribution of B-Cell Responses in Cholera (1999)

The immunoglobulin subclass responses to homologous lipopolysaccharide (LPS) and to cholera toxin (CT) in adult patients infected with Vibrio cholerae O1 and V. cholerae O139 were studied. LPS-specific antibody-secreting cells (ASC) of both the immunoglobulin A1 (IgA1) and IgA2 subclasses were seen, with the IgA1 ASC response predominating in both V. cholerae O1- and O139-infected patients. For antibodies in plasma, by day 11 after onset of disease, all V. cholerae O1- infected patients responded to homologous LPS with the IgA1 subclass (P = 0.001), whereas fewer (68%) responded with the IgA2 subclass (P = 0.007). About 89% of V. cholerae O139-infected patients responded with the IgA1 subclass (P = 0.003), and only 21% responded with the IgA2 subclass (not significant [NS]). Both groups of cholera patients showed significant increases in LPS-specific IgG1, IgG2, and IgG3 antibodies in plasma. In feces, the response to homologous LPS occurred in both groups of patients with the IgA1 and IgA2 subclasses, with 55 to 67% of patients showing a positive response. V. cholerae O1- and O139-infected patients showed CT-specific ASC responses of the different IgG and IgA subclasses in the circulation, and the pattern followed the order IgG1 > IgA1 > IgG2 > IgA2, with low levels of IgG3 and IgG4 ASC. Plasma anti-CT antibody responses in all subclasses were seen by day 11 after onset of disease. Although there were no increases in CT-specific ASC of the IgG3 (NS) and IgG4 (NS) subtypes, there were significant increases of these two subclasses in plasma (P </= 0.001). The response to CT in the fecal extracts was contributed to by both IgA1 and IgA2 isotypes, with 67 to 75% of the patients responding. Thus, the mucosa-derived ASC and fecal antibodies to LPS and CT were of both the IgA1 and IgA2 subclasses; in plasma, the contribution from IgA2 was lower. Very little difference in the B-cell responses to LPS and CT in the different subclasses was seen in the two groups of cholera patients. Vaccines against O1 and O139 cholera ideally should stimulate antibody subclasses that are likely to offer protection.
Nonlinear singular first order partial differential equations of Briot-Bouquet type (1990)

In this paper we will present a generalization of the Briot-Bouquet ordinary differential equation to partial differential equations.
Training the next generation of translational scientists: The Case Western Reserve University Translational Fellows Program (2022)

We are now continuing and improving the program and searching for sustainable support to stabilize the program for a long-term productive future.
Detecting, tracking and predicting human motion inside an industrial robotic cell using a map-based particle filtering strategy (2015)

In order to enable safe and efficient human-robot interaction it is beneficial for the robot control system to be able not only to detect the presence and track the motion of human workers entering the robotic cell, but also to predict in the least possible time their trajectory and the area they are heading to. This paper proposes an innovative particle filtering strategy addressing at the same time the problems of Human Detection and Tracking and Intention Estimation, based on low-cost commercial RGB surveillance cameras, a map of the robotic cell environment, and a probabilistic description of the trajectories followed by human workers inside the cell. Results of several validation experiments are presented.
The role of Pax6 in restricting cell migration between developing cortex and basal ganglia (1999)

It is not clear to what extent restricted cell migration contributes to patterning of the developing telencephalon, since both restricted and widespread cell migration have been observed. Here, we have analysed dorso-ventral cell migration in the telencephalon of Pax6 mutant mice (Small Eye). The transcription factor Pax6 is expressed in the dorsal telencephalon, the cerebral cortex. Focal injections of adenoviral vectors containing the green fluorescent protein were used to follow and quantify cell movements between two adjacent regions in the developing telencephalon, the cerebral cortex and the ganglionic eminence (the prospective basal ganglia). The analysis in wild-type mice confirmed that the cortico-striatal boundary acts as a semipermeable filter and allows a proportion of cells from the ganglionic eminence to invade the cortex, but not vice versa. Ventro-dorsal cell migration was strongly enhanced in the Pax6 mutant. An essential function of Pax6 in the regionalisation of the telencephalon is then to limit the invasion of the cortex by cells originating in the ganglionic eminence. Cortical cells, however, remain confined to the cortex in the Pax6 mutant. Thus, dorsal and ventral cells are restricted to their respective territories by distinct mechanisms.
Predicting trajectories and mechanisms of antibiotic resistance evolution (2020)

Bacteria evolve resistance to antibiotics by a multitude of mechanisms. A central, yet unsolved question is how resistance evolution affects cell growth at different drug levels. Here we develop a fitness model that predicts growth rates of common resistance mutants from their effects on cell metabolism. We map metabolic effects of resistance mutations in drug-free environments and under drug challenge; the resulting fitness trade-off defines a Pareto surface of resistance evolution. We predict evolutionary trajectories of dosage-dependent growth rates and resistance levels, as well as the prevalent resistance mechanism depending on drug and nutrient levels. These predictions are confirmed by empirical growth curves and genomic data of E. coli populations. Our results show that resistance evolution, by coupling major metabolic pathways, is strongly intertwined with systems biology and ecology of microbial populations.
Condensed as‐triazines. Synthesis of 7‐aryl‐8H‐[1,4]thiazino[2,3‐e]‐1,2,4‐triazin‐3(2H)‐one (1993)

Abstract Ring closure of 6‐amino‐3‐oxo‐ as ‐triazine‐5‐thione with α‐haloketones provides the thiazino[2,3‐ e ]‐1,2,4‐triazines which dehydrate via an unusual pathway to give 7‐aryl‐8 H [1,4]thiazino[2,3‐ e ]‐1,2,4‐triazin‐3(2 H )‐ones.
OPTICAL COMB AND INTERFEROMETER DEVELOPMENT FOR LASER SYNCHRONIZATION IN FEMTOSECOND FELS (2012)

We describe a method of synchronizing lasers in FELs to potential sub-femtosecond precision using interferometry and optical clock techniques, and show supporting experimental results. This precision is needed for pump/probe experiments in ultrafast FELs. The proposed system consists of carrier/offset phase stabilized, pulsed lasers synchronized via a single optical frequency delivered over fiber, analogous to RF oscillators synchronized with a reference frequency, but at 200 to 400THz. Our tests of modelocked lasers, interferometers and stabilized CW lasers show that subsystems can perform to the required precision. We have synchronized fiber lasers to less than 10fs jitter using two different frequency comb line locking schemes, and demonstrated interferometers in a working FEL with less than 100as jitter over 150m fiber. Based on these tests and published work by others, we calculate the performance of an optimized, integrated timing system to be less than 1fs in the short term. Long term stability is maintained by feedback from X-ray/optical cross-correlation at the experiment.
Efficacy of Oral Nutritional Supplements in Patients Undergoing Surgical Intervention for Hip Fracture (2022)

<b>Introduction:</b> Malnutrition is considered a risk factor among geriatric individuals with hip fracture, affecting functional healing and recovery, increasing healthcare spending, and associated with high mortality. In this study, we sought to evaluate the clinical efficacy of oral nutritional supplements in geriatric patients undergoing surgery for hip fracture. <b>Material and Methods:</b> We retrospectively analyzed data of 1625 consecutive patients who underwent fixation or arthroplasty for hip fracture in a tertiary medical center between 2017 and 2020. Patients who had no available albumin or body mass index levels were excluded. The study group is of patients who received an advanced formula in the form of an oral nutritional supplement (ONS), and the control group of patients that received no ONS. Peri- and postoperative complications, readmissions, short-term mortality, and albumin levels were compared between the 2 groups. <b>Results:</b> The final cohort included 1123 patients, 298 in the study group and 825 controls, with a follow-up of at least 1-year. Provision of the advanced enriched formula was not associated with 30-day, 90-day, or 1-year mortality (P = .62, P = .52, and P = .72, respectively) or any perioperative complications, such as 30-day or 90-day readmission (P = .37 and P = .1, respectively), revision surgery of any cause (P = .35), and postoperative infection rates (P = .73). Albumin levels on admission and the minimum albumin levels during hospitalization were similar between the groups, but they were significantly higher in the study group before discharge (33.42 g/L vs. 32.79 g/L, P = .01). <b>Discussion:</b> The use of an ONS was not associated with reduced perioperative complications or mortality, although it did affect nutritional status, as indicated by increased albumin levels, a known marker of nutritional status. <b>Conclusions.</b> While current findings do not support ONS use to minimize major postoperative complication after hip fracture surgery, further long-term study is warranted to evaluate subjective and functional outcomes associated with improved nutritional status.
A NOVEL TERRAMECHANICS TESTBED SETUP FOR PLANETARY ROVER WHEEL- SOIL INTERACTION (2009)

The two genes, named BnNHL18A and BnNHL18B, showing sequence homology with Arabidopsis NDR1/HIN1-like (NHL) genes, were isolated from cDNA library prepared with oilseed rape (Brassica napus) seedlings treated with NaCl. The transcript level of BnNHL18A was increased by sodium chloride, ethephon, hydrogen peroxide, methyl jasmonate, or salicylic acid treatment. The coding regions of BnNHL18A and BnNHL18B contain a sarcolipin (SLN)-like sequence. Analysis of the localization of smGFP fusion proteins showed that BnNHL18A is mainly localized to endoplasmic reticulum (ER). This result suggests that the SLN-like sequence plays a role in retaining proteins in ER membrane in plants. In response to NaCl, hydrogen peroxide, ethephon, and salicylic acid treatments, the protein localization of BnNHL18A was changed. Our findings suggest a common function of BnNHL18A in biotic and abiotic stresses, and demonstrate the presence of the shared mechanism of protein translocalization between the responses to plant pathogen and to osmotic stress.
A combinatorial biocatalysis approach to an array of cholic acid derivatives (2002)

A 39-member library of bile acid derivatives was prepared starting from 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid methyl ester using a combinatorial biocatalytic approach. A regioselective oxidation step, catalyzed by hydroxysteroid dehydrogenases, followed by an acylation step with a series of different acyl donors catalyzed by Candida antarctica lipase B, led to the modification of the bile acid scaffold. Each member of the library was obtained in high purity and good yield.
The Video-Based Test of Communication Skills: Description, Development, and Preliminary Findings (2007)

The VTCS is a short, portable test of communication skills. Results reported here suggest that scores reflect differences in skill levels and are generalizable. However, these findings are based on very small sample sizes and must be considered preliminary. Additional work is required before it will be possible to argue confidently that this test in particular, and this approach to testing communication skills in general, is valuable and likely to make a substantial contribution to assessment in medical education.
The role of tumour necrosis factor‐α in combination with interferon‐γ or interleukin‐1 in the induction of immunosuppressive macrophages because of Mycobacterium avium complex infection (1996)

The role of some cytokines including tumour necrosis factor-alpha (TNF-alpha), interleukin-1 alpha (IL-1 alpha), interferon-gamma (IFN-gamma), transforming growth factor-beta (TGF-beta) and interleukin-6 (IL-6) in the generation of immunosuppressive macrophages (M phi s) in host spleen cells of Mycobacterium avium complex (MAC)-infected mice was studied. M phi populations with potent suppressor activity against concanavalin A (Con A)-induced mitogenesis of splenocytes (SPCs) were elicited not only in euthymic but also in athymic nude mice during MAC infection. The suppressor M phi s are, therefore, inducible not only through a T-cell-dependent mechanism but also through T-cell-independent mechanism. However, MAC-induced M phi s of athymic mice displayed about four times lower suppressor activity than those of euthymic mice, indicating that mature T cells are important for M phi activation to the highly immunosuppressive state. Anti-TNF, anti-IFN-gamma, and anti-TGF-beta antibodies (Abs) but not anti-IL-6 Ab inhibited in vivo generation of MAC-induced immunosuppressive M phi s, and the neutralizing efficacy was in the order of anti-IFN-gamma Ab > anti-TNF Ab > anti-TGF-beta Ab. The effects of TNF-alpha, IL-1 alpha, IL-6, and IFN-gamma alone or combinations of them upon the acquisition of the suppressor activity by cultured splenic M phi s were studied. When normal splenic M phi s were treated with each cytokine for 3 days, TNF-alpha, IFN-gamma, and IL-1 alpha alone caused a slight elevation of their suppressive activity. Treatment of the normal M phi s with the combination of either TNF-alpha+IL-1 alpha or TNF-alpha+IFN-gamma yielded a marked increase in the suppressor activity, followed by IL-1 alpha+IFN-gamma. These findings indicate the important roles of TNF-alpha, IFN-gamma, and IL-1 alpha in the generation of MAC-induced suppressor M phi s.
Fixed-point fast Fourier transform error analysis (1976)

A statistical model for roundoff errors is used to predict the output noise of the two common forms of the fast Fourier transform (FFT) algorithm, the decimations in-time and in-frequency. This paper deals with two's complement arithmetic with either rounding or chopping. The total mean-square errors and the mean-square errors for the individual points are derived for radix-2 FFT's. Results for mixed-radix FFT are also given.