gebhart/patrepeval huggingface dataset:
Prolactin, Growth Hormone, and Luteinizing Hormone in the Maintenance of Testicular Luteinizing Hormone Receptors* (1978)

To elucidate further pituitary influence on testicular function, we studied the effect of PRL, GH, and LH alone or in various combinations on the maintenance of testicular LH receptor concentration and testosterone synthesis in response to LH (testicular responsiveness) in hypophysectomized adult rats. Hypophysectomy reduced LH receptor concentration by 80% and testicular responsiveness to LH by 70% 7 days after surgery. Treatment with PRL (75 or 150 μg/day) or with GH (75 or 150 μg/day) initiated within 6 h after surgery and continued twice daily for 6 days partially prevented the loss of LH receptors. The effect of PRL (150 μg/day) plus GH (150 μg/day) on LH receptor concentration was additive. The combination of LH (5 μg/day), PRL, and GH prevented any loss of LH receptors after hypophysectomy. A positive effect of LH on its receptor occurred in the presence of PRL. Treatment of hypophysectomized rats with 5 /μg LH plus 150 /μg PRL enhanced the effect observed with PRL alone (1.31 pmol/testis vs. 1.68 pmol/testis, P < 0.05). We previously reported that administration of 5, 25, or 50 μg LH/day to hypophysectomized rats caused a further decrease in LH receptor concentration (1). In the present study, administration of PRL (150 μg sol;day) together with 25 or 50 μg LH/day prevented LH from exerting a negative effect on LH receptor concentration. Similar treatment with GH plus LH neither allowed a positive effect of LH nor prevented higher doses of LH from exerting a negative effect on LH receptor concentration. Despite the ability of PRL to increase LH receptor concentration, PRL treatments did not enhance testicular responsiveness to LH. Only when LH was administered together with either PRL and/or GH was testicular responsiveness to LH maintained at intact control values. These data indicate that 1) maintenance of testicular LH receptors is at least partially dependent on PRL and GH; 2) PRL prevents LH from exerting a negative effect and allows LH to have a positive effect on its receptor; 3) PRL and GH seem to act at different sites and by different mechanisms; and 4) hormonal regulation of LH receptor concentration is distinct from hormonal regulation of testicular responsiveness to LH.
Supplementary material to "Sources of black carbon at residential and traffic environments" (2021)

Table The contribution of rBC (the sum of C2 + , C3 + and C4 + ) to the mass spectra of the PMF factors at the residential site.
<title>Endoluminal photodynamic therapy: influence of tissue optical properties on light fluence in the cylindrical diffusing fiber geometry</title> (1996)

A Monte Carlo model has been developed to simulate the fluence distribution in a fully cylindrical geometry, when a finite linear light source is placed on the axis of a hollow organ during PDT treatment. Height and radius of the cavity, scattering and absorption coefficients, anisotropy factor (g), refractive index of medium and cavity are required as input by the MC code. Data obtained from this model were subsequently compared with experimental results using a tissue simulating phantom. An aqueous solution of Intralipid-10 percent and black ink were used to simulate optical properties. A helium-neon laser, coupled to a cylindrical diffuser was employed as light source. A good agreement between the MC simulations and experimental measurements was found.
Microscopy in the Study of Polymorph Stability (2004)

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
[Antibiotic resistance: epidemiological developments and preventive measures]. (2007)

European countries differ with regard to the occurrence of resistant micro-organisms. This indicates that the development of resistance can be influenced. Resistance levels are low in the Netherlands, but the resistance to various antibiotics is increasing. Factors that are known to contribute to antibiotic resistance are: the dosage and duration of antibiotic exposure and the type of antibiotic used in combination with a specific micro-organism. The selection pressure can be decreased by making use of antibiotics with a narrow spectrum. A new pharmacodynamic finding is that the dosage of antibiotics can be regulated in a way that minimises the selection of resistant clones. Implementation ofnational guidelines for the treatment of infections will contribute to more efficient use of antibiotics and the control of antibiotic resistance in the Netherlands.
Topical carbonic anhydrase inhibitors (1997)

Dorzolamide, a topically active carbonic anhydrase inhibitor, is an effective new glaucoma medication that creates a decrease in intraocular pressure similar to that produced by beta-blockers. When beta-blockers are contraindicated, dorzolamide may be used as a first-line therapy. It has excellent additivity with other topical ocular hypotensive medications, including beta-blockers and pilocarpine. Systemic side effects are minimal, particularly compared with those of oral carbonic anhydrase inhibitors. However, local side effects, including corneal edema in patients with borderline endothelial function, may occur. Decreased visual acuity and allergic reactions, which occur frequently, may curtail the use of dorzolamide in some patients.
Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. (2001)

Light absorption by RPE melanin can explain differences between the in vivo and ex vivo estimates of the rate of lipofuscin accumulation. Declining fluorescence at old age may represent removal of atrophic RPE cells. The spatial distribution of lipofuscin generally matches that of rods and reflects, rather than predicts, the pattern of age-related loss of rod photoreceptors.
Revised list of acronyms (2005)

Journal Article Revised list of acronyms Get access Nobuyuki Miyasaka Nobuyuki Miyasaka Search for other works by this author on: Oxford Academic Google Scholar Modern Rheumatology, Volume 15, Issue 1, 1 February 2005, Pages 1–3, https://doi.org/10.3109/s10165-004-0371-9 Published: 01 February 2005
Japanese Advanced Semiconductor Manufacturing (1992)

Abstract : During the week of April 5 through 9, 1993 an ARPA technology assessment team visited four Japanese semiconductor companies and one Japanese university to evaluate Japanese trends in flexible manufacturing and assess their strategic direction. Of the manufacturing facilities visited, the Mitsubishi 16Mb DRAM facility in Saijo was the most advanced and provided good insight into the Japanese manufacturing directions. All of the manufacturing sites (excluding Tohoku University) are on the classic mega-fab trend which will result in the multi-billion dollar next-generation facilities. Although several of the companies visited knew of the MMST program, we saw no evidence of an analogous Japanese program. Contrary to US manufacturers, the Japanese manufacturers have little concern over the capability and cost of lithography tools and processes.
Pre-Trained Convolutional Neural Networks for Breast Cancer Detection Using Ultrasound Images (2021)

Volunteer computing based data processing is a new trend in healthcare applications. Researchers are now leveraging volunteer computing power to train deep learning networks consisting of billions of parameters. Breast cancer is the second most common cause of death in women among cancers. The early detection of cancer may diminish the death risk of patients. Since the diagnosis of breast cancer manually takes lengthy time and there is a scarcity of detection systems, development of an automatic diagnosis system is needed for early detection of cancer. Machine learning models are now widely used for cancer detection and prediction research for improving the successive therapy of patients. Considering this need, this study implements pre-trained convolutional neural network based models for detecting breast cancer using ultrasound images. In particular, we tuned the pre-trained models for extracting key features from ultrasound images and included a classifier on the top layer. We measured accuracy of seven popular state-of-the-art pre-trained models using different optimizers and hyper-parameters through fivefold cross validation. Moreover, we consider Grad-CAM and occlusion mapping techniques to examine how well the models extract key features from the ultrasound images to detect cancers. We observe that after fine tuning, DenseNet201 and ResNet50 show 100% accuracy with Adam and RMSprop optimizers. VGG16 shows 100% accuracy using the Stochastic Gradient Descent optimizer. We also develop a custom convolutional neural network model with a smaller number of layers compared to large layers in the pre-trained models. The model also shows 100% accuracy using the Adam optimizer in classifying healthy and breast cancer patients. It is our belief that the model will assist healthcare experts with improved and faster patient screening and pave a way to further breast cancer research.
Two-dimensional aperture synthesis radiometers in a low earth orbit mission and instrument analysis (2002)

The mission and configuration of spaceborne two-dimensional synthetic aperture radiometers are considered in order to assess the possibilities and limits of this sensor type for global soil moisture monitoring. Results are presented which include the selection of orbit, scan type and basic sensor parameters as well as predictions for performance and mass/power requirements of different sensor options.
Atomic Local Coordinations and Multivalent States in YBa 2 Cu 3 O 9-δ Superconductors (1987)

EXAFS and XANES spectra at the edges of Cu and Y have been measured in the YBa2Cu3O9-δ(δ 2) superconductor. The oxygen coordination around the two metals is found to generally agree with the model suggested by diffraction experiments, especially as the occurrence of two distinct distances between Cu and O along the perovskite structure c-axis is concerned. Conversely, some evidence is found for a partial occupation of the oxygen sites in the yttrium plane, a result excluded by diffraction experiments. This is better supported by EXAFS spectra at the Y-edge. The XANES spectra of the superconductor are remarkably different from those of Cu oxides suggesting the presence of both divalent and trivalent Cu, in agreement with EXAFS and diffraction results.
LATTE: Location And Time Triggered Email (2004)

Abstract. Computer users, especially mobile ones, have developed a significant dependency on electronic communication. Enhancing the capabilities of such communication by adding an awareness of context such as location and time increases the quality and intuitiveness of the services available to the mobile user. This paper describes the design and implementation of a context-aware messaging system called LATTE (Location And Time Triggered Email). LATTE is based on the email paradigm, and extends it to include dynamic consideration of location and time to determine the appropriate recipients for a message. It uses SMTP (Simple Mail Transfer Protocol) for message delivery and an event middleware as the underlying communication infrastructure.
Service provider DevOps for large scale modern network services (2015)

Network service providers are facing challenges for deploying new services mainly due to the growing complexity of software architecture and development process. Moreover, the recent architectural innovation of network systems such as Network Function Virtualization (NFV), Software-defined Networking (SDN), and Cloud computing increases the development and operation complexity yet again. One of the emerging solutions to this problem is a novel software development concept, namely DevOps, that is widely employed by major Internet software companies. Although the goals of DevOps in data centers are well-suited for the demands of agile service creation, additional requirements specific to the virtualized and software-defined network environment are important to be addressed from the perspective of modern network carriers. In this paper, we thoroughly debate DevOps requirements for developing a modern service creation platform by taking EU FP7 project UNIFY as a reference architecture and suggest the corresponding extensions of UNIFY interfaces that meet the discovered requirements.
Periodontal Repair in Dogs: Expanded Polytetrafluoroethylene Barrier Membranes Support Wound Stabilization and Enhance Bone Regeneration (1993)

A wound stabilizing effect of expanded polytetrafluoroethylene (ePTFE) membranes was evaluated in supra-alveolar periodontal defects in 5 beagle dogs. The defects, 5 to 6 mm in height, were surgically created around the 2nd, 3rd, and 4th mandibular premolar teeth in contralateral jaw quadrants. The root surfaces were conditioned with heparin, which, in this model, has been demonstrated to compromise periodontal healing and result in formation of a long junctional epithelium. Wound closure included application of ePTFE membranes around each premolar tooth in one jaw quadrant in each dog and flap positioning coronal to the cemento-enamel junction in both jaw quadrants. Healing progressed uneventfully except for 3 teeth in 2 dogs, which experienced membrane exposure. The dogs were sacrificed after a 4-week healing period and tissue blocks were prepared for histometric analysis. Connective tissue repair in heparin+membrane-treated teeth averaged 98% of the defect height compared to 84% in control heparin-treated teeth (P < or = 0.05). Junctional epithelium formation was smaller in membrane-treated teeth than in control teeth (P < or = 0.05) and was usually terminated coronal to the membrane. Bone regeneration was enhanced in membrane-treated teeth compared to controls (P < or = 0.01) and was strongly correlated to the area under the membrane in teeth without membrane exposure (r2 = 0.993; P = 0.002). This correlation was reduced when teeth with membrane exposure were included in the analysis (P < or = 0.05). Cementum regeneration was minimal under both treatment conditions. Root resorption was increased in membrane-treated compared to control teeth (P < or = 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Creation and annihilation of phase singularities in a focal field (1997)

It is well known that uniform illumination of a lens leads to a focal field with a pattern of dark Airy rings in the focal plane, whereas this is not the case for Gaussian illumination. We show theoretically and experimentally that in the transition between the two cases the Airy rings, being phase singularities, reorganize themselves by means of a creation-annihilation process leading to new dark rings outside the focal plane.
Supplementary Movie 2 from Intravital Imaging Reveals Transient Changes in Pigment Production and Brn2 Expression during Metastatic Melanoma Dissemination (2023)

Supplementary Movie 2 from Intravital Imaging Reveals Transient Changes in Pigment Production and Brn2 Expression during Metastatic Melanoma Dissemination
Is Objective News Possible? (2010)

Abstract The structure of this chapter is as follows. It briefly explains the nature of objective news and of the debate regarding its possibility. It then assesses the main arguments for the unattainability of objective news. A close examination of these arguments shows that, contrary to widespread belief, journalists who try to provide objective news are not striving in vain. The chapter discusses the effect of competing journalistic aims and other limitations on our efforts to generate objective news. It suggests that the unwarranted skepticism regarding the possibility of objective news is an artifact of the changing priorities of journalists and inadequate journalistic methods, and that the only real issue is how we can better train those journalists who want to generate objective news.
Preparation of Hollow Fiber Membranes Based On Poly(4-methyl-1-pentene) for Gas Separation (2021)

New hollow fiber gas separation membranes with a non-porous selective layer based on poly(4-methyl-1-pentene) (PMP) granules have been obtained using the solution-free melt spinning process. The influence of the preparation conditions on the geometry of the obtained samples was studied. It was found that a spin head temperature of 280 °C and a specific mass throughput of 103 g mm−2 h−1 are optimal to obtain defect-free, thin-walled hollow fibers in a stable melt spinning process, using the given spinneret geometry and a winding speed of 25 m/min. The gas permeability and separation properties of new fibers were studied using CO2/N2 and CO2/CH4 mixtures, and it was found that the level of gas selectivity characteristic of homogeneous polymer films can be achieved. The features of the gas mixture components permeability below and above the PMP glass transition temperature have been experimentally studied in the range of CO2 concentrations from 10 to 90% vol. The temperature dependences of the permeability of the CO2/CH4/N2 mixture through the obtained HF based on PMP have been investigated, and the values of the apparent activation energies of the permeability have been calculated, which make it possible to predict the properties of membrane modules based on the obtained membranes in a wide temperature range.
DNA-dependent Protein Kinase and Checkpoint Kinase 2 Synergistically Activate a Latent Population of p53 upon DNA Damage (2004)

The role of the checkpoint kinase 2 (Chk2) as an upstream activator of p53 following DNA damage has been controversial. We have recently shown that Chk2 and the DNA-dependent protein kinase (DNA-PK) are both involved in DNA damage-induced apoptosis but not G(1) arrest in mouse embryo fibroblasts. Here we demonstrate that Chk2 is required to activate p53 in vitro as measured by its ability to bind its consensus DNA target sequence following DNA damage and is in fact the previously unidentified factor working synergistically with DNA-PK to activate p53. The gene mutated in ataxia telangiectasia is not involved in this p53 activation. Using wortmannin, serine 15 mutants of p53, DNA-PK null cells and Chk2 null cells, we demonstrate that DNA-PK and Chk2 act independently and sequentially on p53. Furthermore, the p53 target of these two kinases represents a latent (preexisting) population of p53. Taken together, the results from these studies are consistent with a model in which DNA damage causes an immediate and sequential modification of latent p53 by DNA-PK and Chk2, which under appropriate conditions can lead to apoptosis.
Real-world scenarios help improve selection of radiology employees. (1999)

Choosing the right candidate through the interview process is critical, particularly in light of rapidly changing skills in various technologies. The authors have changed the interviewing process at Jeanes Hospital in Philadelphia in order to examine and evaluate multiple objectives simultaneously. To do this, they created an instrument that elicits impromptu responses to real-world radiology situations. Such responses help assess a potential candidate's training, emotional strength, technical experience and growth potential. They also determine how much additional training the potential candidate will need to be effective in the department. Using the instrument helps sharpen the assessment of candidate traits such as face-to-face communication skills and response time. The impact on hiring is positive. Quality staff, improved patient care and improved patient safety are only some of the results. Many of the questions included on the instrument come from past problem situations and help the interviewers to determine whether a candidate understands underlying issues and the seriousness of situations. The goal is to ensure that patient care and productivity are not hampered by unusual situations. When a concrete difference is detected between a candidate's response and the department's needs, it is possible to assess the cost-effectiveness of training for the discrepancy. For entry-level candidates, the question is whether the person is trainable. Consistently using this interview document forces hiring managers to identify specific abilities, traits and experience desirable in the workplace.
Analysis of Superplastic Deformation of AZ31 Magnesium Alloy (2007)

AZ31 is a magnesium alloy possessing good mechanical properties, which makes it particularly attractive for automotive applications. Yet, in order to advance the utilization of this alloy, a broad database of its superplastic behavior is needed. This work presents the results of a comprehensive study on the elevated temperature superplastic behavior of the AZ31 magnesium alloy. Flow stress, fracture strain and strain sensitivity index maps were constructed over a wide range of strain rates, covering temperatures between 325 and 450 °C.
Nutrition and food for health and longevity (2015)

None of the nutritional components is by itself good or bad, and none of the foodstuffs is either healthy or unhealthy. Nutrition can lead to either good effects or bad effects, and food can have consequences, making us either healthy or unhealthy. It is the quantity, quality, frequency, and emotional satisfaction that<br/>determine whether any particular food can help us achieve the aim of maintaining and improving health, and delaying, preventing, or treating a disease
Theoretical framework for spectrum analysis in ultrasonic tissue characterization (1983)

An analytic model is described for application in ultrasonic tissue characterization. The model is applicable to clinical broadband pulse echo systems. It treats spectra derived from received echo signals and relates them to physical tissue properties. The model can be applied to deterministic tissue structures (e.g., retinal detachments, larger blood vessels, and surface layers of the kidney) and to stochastic tissue structures (e.g., various tumors). The beam patterns included in the model are those generated by focused transducers typically used in high-resolution clinical ultrasound. Appropriate calibration procedures are also treated; these are needed for interpretation of absolute spectral parameters. The results obtained with the analytic model have been used to design a digital processing system and the associated techniques which are now being applied during examinations of the eye and abdominal organs. The results have proven useful in interpreting data from various types of tissues. To illustrate the application of these results, representative clinical data, obtained from the digital system, are presented for two types of tissue architectures. The first case is a detached retina representing a deterministic structure characterized by well-defined thickness and reflection coefficients. The second case is asteroid hyalosis and represents a stochastic entity in which the positions of small scattering particles are best described in statistical terms, and characterization is accompanied by means of normalized power spectra.
Effect of spray calcination conditions on Synroc-D crystalline phases. [Titanate-based crystalline ceramic] (1983)

Spray calcination conditions modified the crystalline phase composition formed during hot pressing of Synroc-D. The final desired phases can be controlled by the choice of calciner temperature and atomizing gas. A subsequent stage of redox calcination should not be required prior to hot pressing.