gebhart/patrepeval huggingface dataset:
Data from Antibody Response to Merkel Cell Polyomavirus Associated with Incident Lymphoma in the Epilymph Case–Control Study in Spain (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Merkel cell polyomavirus (MCV) has been identified as the cause of Merkel cell carcinoma. The increased incidence of chronic lymphocytic leukemia in Merkel cell cancer cohorts and the lymphotropic properties of the virus suggest a possible viral association with lymphomagenesis. To investigate this potential role, we explored seroreactivity against MCV VP1 capsids within the Epilymph case–control study in Spain.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; Serum samples from 468 incident lymphomas, categorized into up to 11 entities, and 522 controls frequency matched by age, sex, and recruitment center were tested for MCV antibodies by enzyme immunoassay using Virus-Like-Particles. Adjusted multinomial logistic regression was used to estimate the OR and 95% confidence interval (CI) associated to MCV seroprevalence. Immunosuppressed subjects were excluded.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; MCV seroprevalence was 82% in controls and 85% in lymphoma cases. Among 11 lymphoma categories, MCV seropositivity was significantly higher in diffuse large B-cell lymphomas (DLBCL; 96.4%; OR = 6.1, 95%CI = 1.9–19.8), as compared with controls. MCV prevalences were also higher in follicular lymphoma, lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, Hodgkin lymphoma, and mature T-cell lymphoma but differences did not reach statistical significance. Lower prevalences were observed for multiple myeloma and other B-cell lymphoma. Exclusion of samples collected after start of treatment did not change the results. In a subset analysis, no significant association was observed between BKV and JCV seroprevalence and DLBCL.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; The association observed between serologic evidence of MCV exposure and DLBCL warrants further research.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Impact:&lt;/b&gt; MCV might be involved in the pathway of DLBCL and other lymphomas. &lt;i&gt;Cancer Epidemiol Biomarkers Prev; 21(9); 1592–8. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Chemical Composition of the Essential Oil of Teucrium yemense Deflers (2008)

The chemical composition of the essential oil (EO) obtained by hydrodistillation from the leaves of Teucrium yemense Deflers was determined by GC-MS. Twelve compounds accounting to 77.7% of the total oil were identified. Sesquiterpene hydrocarbons (73.9%) were the predominant portion of the oil with �-cadinene (34.9%), �-caryophyllene (22.7%), α-humulene (6.1%), and α-selinene (5.4%) as the main constituents.
Intramarrow Bone Morphogenetic Protein 4 Gene Delivery Enhances Early Implant Stability in Femurs of Ovariectomized Rabbits (2011)

The results of this study suggest that intramarrow adenoviral gene delivery of BMP4 enhances peri-implant bone healing and improves early implant stability in osteoporotic rabbit femurs.
Purification of Thermotoga maritima enzymes for the degradation of cellulosic materials (1995)

A separation procedure for the analysis of the enzyme components of the hyperthermophilic bacterium Thermotoga maritima involved in cellulose and xylan degradation was developed. Resolution of the enzymes was achieved by a combination of fast protein liquid chromatography anion exchange and hydrophobic interaction chromatography. Enzyme fractions were assayed for hydrolysis of Avicel, carboxymethylcellulose (CMC), beta-glucan, laminarin, xylan, p-nitrophenyl-beta-D-glucoside, p-nitrophenyl-beta-D-cellobioside, p-nitrophenyl-beta-D-xyloside, p-nitrophenyl-alpha-L-arabinofuranoside, and 4-O-methyl-glucuronosyl-xylotriose. The activities of two cellulases, one laminarinase, one xylanase, two putative beta-D-xylosidases, alpha-D-glucuronidase, and alpha-L-arabinosidase were identified. Because of their selective retardation on a Superdex gel filtration column, the two cellulases could be purified to homogeneity. According to sodium dodecyl sulfate-polyacrylamide gel electrophoresis, molecular masses of 27 and 29 kDa, respectively, were determined for cellulase I and cellulase II. Maximal activities of both enzymes were observed at 95 degree C between pH 6.0 and 7.5. In the presence of 2.5 M NaC1 the purified enzymes retained about 90% of their initial activities after a 6-h incubation at 80 degree C. On the basis of its activity towards CMC, cellulase I was classified as endo-beta-1,4-glucanase. Cellulase II was able to attack Avicel in addition to CMC, beta-glucan, and p-nitrophenyl-beta-D-cellobioside. It releases cellobiose and cellotriose from Avicel. The latter product is further cleaved into glucose and cellobiose. Cellulase II may therefore be classified as exo-beta-1,4-glucanase.
Solving A Class of Mean-Field LQG Problems (2019)

In this work, we study a class of mean-field linear quadratic Gaussian (LQG) problems. Under suitable conditions, explicit solutions of the distribution-dependent optimal control problems are obtained. Riccati systems are derived by directly solving the associated master equations. Some extensions on controls with partial observations are also considered.
A simple finite element-based framework for the analysis of elastic pseudo-rigid bodies (1999)

This article advocates a general procedure for the numerical investigation of pseudo-rigid bodies. The equations of motion for pseudo-rigid bodies are shown to be mathematically equivalent to those corresponding to certain constant-strain finite element approximations for general deformable continua. A straightforward algorithmic implementation is achieved in a classical finite element framework. Also, a penalty formulation is suggested for modelling contact between pseudo-rigid bodies. Representative planar simulations using a non-linear elastic model demonstrate the predictive capacity of the pseudo-rigid theory, as well as the robustness of the proposed computational procedure. Copyright © 1999 John Wiley & Sons, Ltd.
Amoebicidal Activity of Multipurpose Contact Lens Solutions (2005)

The multipurpose solution containing polyquaternium-1 and myristamidopropyl dimethylamine reduced more cysts and trophozoites than did the alternative solution tested. Because there were differences in the effect of the multipurpose solutions on strains, it is recommended that more than one strain or species of Acanthamoeba be tested to determine efficacy of disinfecting solutions. The lack of difference between disinfection times may indicate that 4 hours could be considered as an adequate disinfecting time to ensure sufficient kill of Acanthamoeba species.
¿Podrá salvar la reforma a la ONU?: Oportunidades para la creación de un organismo multilateral eficaz para el siglo XXI (2005)

En una epoca de crisis del sistema internacional y de inquietud entre los que apoyan el multilateralismo, vale la pena recordar las palabras de Eleanor Roosevelt: ?el futuro pertenece a quienes creen en la belleza de los suenos?. Defensora de la Organizacion de las Naciones Unidas desde sus inicios, es posible que no anduviera muy desencaminada cuando se refirio a la belleza de los suenos. En efecto, el concepto de una organizacion de participacion mundial creada para poner fin al azote de las guerras y promover la paz sigue siendo, pese a que la ONU inicia su 60o ano, una mision ilusoria.
Laparoscopic telesurgical workstation (1998)

Robotic telesurgery is a promising application of robotics to medicine, aiming to enhance the dexterity and sensation of minimally invasive surgery through millimeter-scale manipulators under control of the surgeon. With appropriate communication links, it would also be possible to perform remote surgery for care in rural areas where specialty care is unavailable, or to provide emergency care en route to a hospital. The UC Berkeley/Endorobotics/UCSF Telesurgical Workstation is a master-slave telerobotic system, with two 6 degree of freedom (DOF) robotic manipulators, designed for laparoscopic surgery. The slave robotic has a 2 DOF wrist inside the body to allow high dexterity manipulation in addition to the 4 DOF of motion possible through the entry port, which are actuated by an external gross motion platform. The kinematics and the controller of the system are designed to accommodate the force and movement requirements of complex tasks, including suturing and knot tying. The system has force feedback in 4 axes to improve the sensation of telesurgery. In this paper, the telesurgical system will be introduced with discussion of kinematic and control issues and presentation of in vitro test results.
Corrosion of Ferrous Structural Alloys in Biomass Derived Fuels and Organic Acids (2021)

This work investigated the corrosivity of biomass-derived liquid fuels and organic acids associated with bio-oils and conducted a corrosion compatibility evaluation of several structural ferrous alloys in the fuels and acids. The acidity parameters and solution conductivity values were higher in raw pyrolysis bio-oils than postprocessed oils with significant corrosion attack for carbon steel and Fe-2.25Cr-1Mo. However, higher-grade stainless steels, ferritic Fe-15Cr (15Cb) and austenitic types 304L and 316L, showed negligible corrosion loss, whereas lower-Cr ferritic grades 409, 410, and 416 were attacked. Metal leaching tests and electrochemical impedance spectroscopy measurements revealed superior corrosion resistance of 316 over 410 stainless steels in solutions of formic and oxalic acids that can be present in bio-oils. The corrosion evaluation methods utilized in this work provide effective screening tools to identify the compatible structural alloys for bio-oils.
Bovine tuberculosis: making a case for effective surveillance (2010)

In 2008, a cow with marked gross lesions suspicious for bovine tuberculosis (bTB) was identified by meat inspection at home slaughtering in north-western Germany. Epidemiological investigations led to the identification of another 11 affected farms with a total of 135 animals which reacted positive to the skin test. Eight affected farms had been in trade contact with the putative index farm. While the source for the initial introduction remained unknown, it was shown that all isolates tested shared the same molecular characteristics suggesting a common source of infection. The findings demonstrate that bTB can easily be transmitted via animal trade and may remain undetected for years in herds in the absence of tuberculin testing. Hence, we believe that bTB surveillance should not rely only on meat inspection, but on a combination of both meat inspection and intradermal tuberculin testing.
Population biology of Streptococcus pneumoniae isolated from oropharyngeal carriage and invasive disease The GenBank accession numbers for the sequences of the trpA/B alleles determined in this study are AF157817 to AF157826. (1999)

The population structure of Streptococcus pneumoniae in a sample of 134 carried antibiotic-susceptible isolates, and 53 resistant and susceptible invasive isolates, was examined using a DNA-based version of multilocus enzyme electrophoresis: multilocus restriction typing (MLRT). This involved RFLP analysis of PCR products generated from nine loci of housekeeping genes located around the pneumococcal chromosome. The combination of alleles at each of the nine loci gave an allelic profile or restriction type (RT). All carried (throat or nasopharyngeal) isolates from children or adults in Oxford and Manchester, UK, and from an HIV-seropositive cohort in Nairobi, Kenya, showed an epidemic population structure. Twelve carried clonal groups, each with different serotypes, were identified at both locations within the UK. Almost all of the carried clones examined (16/17) were found to possess identical RTs or sequence types (STs) to invasive isolates, indicating that frequently carried clones are also associated with cases of invasive disease. As expected from previous studies, the population of 53 invasive, mainly penicillin-resistant, isolates was also found to be at linkage equilibrium. Serotype switching was identified among 14% of RTs that possessed two or more members, or 5.7% of individual isolates within these RTs. In support of a population structure in which there is frequent recombination, there is also clear evidence that the trpA/B locus within pneumococci has evolved by horizontal gene transfer. A non-serotypable isolate from an HIV-seropositive patient in Kenya was clearly genetically distinct from other strains studied, with unique alleles at eight out of nine loci examined. However, it was initially identified as a pneumococcus by a 16S RNA gene probe (Gen-Probe), optochin susceptibility and the presence of pneumolysin and autolysin.
Paliperidone palmitate: Japanese postmarketing mortality results in patients with schizophrenia (2016)

Based on this review of the 32 fatal cases in the PP1M EPPV period, the observed death rate does not necessarily result from a risk with PP1M treatment in Japanese patients. The higher mortality reporting rates in Japan may be attributed to a variety of factors: the effectiveness of mortality reporting in the unique Japanese EPPV program, the advanced age of the fatal cases, high cardiovascular risk factors, multiple underlying diseases and high antipsychotic polypharmacy among the cases with fatal outcomes.
Evaluation of the mechanical properties of cements with fillers derived from the CO2 reduction of cement plants (2019)

This work introduces a novel method for the development of CO2 recovery systems derived from the production process of cement in order to obtain CaCO3 nanofiller in cement-based composites. Research was carried out in collaboration between the Department of Applied Science and Technology (DISAT) and the Department of Structural, Construction and Geotechnical Engineering (DISEG) of Politecnico di Torino. The objective of this method was dual. Firstly, it aimed to obtain a precipitated calcium carbonate - nanoCaCO3 - with a high degree of purity. Secondly, it aimed to optimize the characteristics of these nanoparticles e.g. additional percentages, morphology, particle size distribution or crystal phase, according to their use in cement-based composites. The synthesized nanoCaCO3 particles were subsequently added into the cementitious composites in different percentages according to the weight of the cement, in order to understand their behaviour within the cement matrix. The mechanical properties were also evaluated, both at 7 and 28 days, through three point bending and compression tests. The results of the mechanical tests showed a promising improvement in strength and toughness. This study is a first step towards developing a CO2 circular economy.
Practical Applications (2010)

This chapter contains sections titled: Introduction Akutagwa River Side Project in Japan Florence New Station Project in Italy Sagrada Família Church in Spain Pedestrian Bridge Project in Australia Conclusion References
Understanding Scenes With Shadows (1971)

Work reported herein was conducted at the Artificial Intelligence Laboratory, a Massachusetts Institute of Technology research program supported by the Advanced Research Projects Agency of the Department of Defense, and was monitored by the Office of Naval Research under Contract Number N00014-70-A-0362-0002.
Nuclear Binding of [125I]Triiodothyronine in Dispersed Cultured Skin Fibroblasts from Patients with Resistance to Thyroid Hormone* (1982)

To reexamine the possibility of a defect in nuclear receptors for T3 in patients with resistance to thyroid hormone, we have developed a method for measuring the nuclear uptake of [125I]T3 by intact dispersed fibroblasts grown from human skin. Fibroblasts were grown in serial passage, dispersed with mild trypsin digestion, and incubated at 37 C in serum-free medium with increasing concentrations of [125I]T3 in the presence or absence of unlabeled T3. After 60 min, cells were collected, and nuclei were isolated and counted for radioactivity. With fibrobiasts from eight normal subjects (four males and four females; age, neonate to 53 yr), the nuclear binding of [125I]T3 was saturable and demonstrated a single class of high affinity receptors, with a mean (±SE) binding capacity (Ro) of 3800 ± 500 nuclear sites/cell and a mean (±SE) apparent dissociation constant (Kd) of 1.0 ± 0.1 × 1O−10 M. Analysis of [125I]T3 nuclear binding in normal fibroblasts performed between passages 3–15 showed no significant variation in these parameters. Competition of nuclear [125I]T3 binding by thyroid hormone analogs showed affinity characteristics similar to those seen with nuclear T3 receptors in other tissues, such as rat liver. When fibroblasts from four patients from four different kindreds with thyroid hormone resistance [three males (age, 1 6/12 to 17 yr) and one female (age, 11.5 years)] were analyzed at multiple passages (3–12), no significant differences in the mean (±SE) characteristics of nuclear [125I]T3 binding were detectable (Ro = 5380 ± 650 sites/cell; Kd = 1.28 ± 0.17 × 10−10 M). However, the values for both nuclear T3 binding parameters from one patient's fibroblasts were above the normal range. We conclude that fibroblasts from three patients from three separate families with the syndrome of resistance to thyroid hormone have normal affinity and capacity for nuclear binding of [I25I]T3. The fourth patient's cells had a slight decrease in affinity (i.e. increased Kd) and a slightly elevated nuclear binding capacity for T3, but it is unclear whether these characteristics in nuclear T3 binding parameters are related to this patient's resistance to thyroid hormone. Assuming that these fibroblasts manifest resistance to thyroid hormone, these data suggest that the target organ defect in most cases of thyroid hormone resistance is not in the number or affinity of nuclear T3 receptors or in T3 cellular or nuclear transport mechanisms; the defect(s) may reside in nonnuclear T3 receptors, in postreceptor processes, or in qualitative properties of nuclear T3 receptors not demonstrated in conventional binding assays. Alternatively, it is possible that tissue resistance due to a nuclear receptor abnormality is present in these patients, but is not shared by cultured fibroblasts.
Differences in the Pathogenicity of the p.H723R Mutation of the Common Deafness-Associated SLC26A4 Gene in Humans and Mice (2013)

Mutations in the SLC26A4 gene are a common cause of human hereditary hearing impairment worldwide. Previous studies have demonstrated that different SLC26A4 mutations have different pathogenetic mechanisms. By using a genotype-driven approach, we established a knock-in mouse model (i.e., Slc26a4(tm2Dontuh/tm2Dontuh) mice) homozygous for the common p.H723R mutation in the East Asian population. To verify the pathogenicity of the p.H723R allele in mice, we further generated mice with compound heterozygous mutations (i.e., Slc26a4(tm1Dontuh/tm2Dontuh) ) by intercrossing Slc26a4(+/tm2Dontuh) mice with Slc26a4(tm1Dontuh/tm1Dontuh) mice, which segregated the c.919-2A>G mutation with an abolished Slc26a4 function. Mice were then subjected to audiologic assessments, a battery of vestibular evaluations, inner ear morphological studies, and noise exposure experiments. The results were unexpected; both Slc26a4(tm2Dontuh/tm2Dontuh) and Slc26a4(tm1Dontuh/tm2Dontuh) mice showed normal audiovestibular phenotypes and inner ear morphology, and they did not show significantly higher shifts in hearing thresholds after noise exposure than the wild-type mice. The results indicated not only the p.H723R allele was non-pathogenic in mice, but also a single p.H723R allele was sufficient to maintain normal inner ear physiology in heterozygous compound mice. There might be discrepancies in the pathogenicity of specific SLC26A4 mutations in humans and mice; therefore, precautions should be taken when extrapolating the results of animal studies to humans.
Ultrashort pulse cascaded third-harmonic generation in two-dimensional quasi-phase-matching structure (2007)

We propose and demonstrate group-velocity mismatch compensation in cascaded third-harmonic generation. Second- and third-harmonic generation efficiency of 25% and 7%, respectively, were experimentally obtained for femtosecond pulses by use of two-dimensionally periodically-poled lithium niobate.
Tuning electrospinning parameters for production of 3D-fiber-fleeces with increased porosity for soft tissue engineering applications (2011)

Degrapol® and PLGA electrospun fiber fleeces were characterized with regard to fiber diameter, alignment, mechanical properties as well as scaffold porosity. The study showed that electrospinning parameters affect fiber diameter and alignment in an inverse relation: fiber diameter was increased with increased flow rate, with decrease in working distance and collector velocity, whereas fiber alignment increased with the working distance and collector velocity but decreased with increased flow rate. When Degrapol® or PLGA-polymers were co-spun with increasing ratios of a water-soluble polymer that was subsequently removed; fibrous scaffolds with increased porosities were obtained. Mechanical properties correlated with fiber alignment rather than fiber diameter as aligned fiber scaffolds demonstrated strong mechanical anisotropy. For co-spun fibers the Young's modulus correlated inversely with the amount of co-spun polymer. Cell proliferation was independent of the porosity of the scaffold, but different between the two polymers. Furthermore, fibrous scaffolds with different porosities were analyzed for cell infiltration suggesting that cell infiltration was enhanced with increased porosity and increasing time. These experiments indicate that 3D-fiber fleeces can be produced with controlled properties, being prerequisites for successful scaffolds in tissue engineering applications.
Ag nanoparticles obtained by pulsed laser ablation in water: surface properties and SERS activity (2015)

We studied the surface properties and reactivity of silver nanoparticles obtained by picosecond or nanosecond pulsed laser ablation in water and with 1064‐nm wavelength. Ultraviolet–visible spectroscopy results and subsequent modelling by Mie theory indicated the presence of an oxide layer on the nanoparticle surface, which favours the colloidal stability, but reduces the interaction with the environment. The oxide layer is also responsible for the reduced surface enhanced Raman spectroscopy (SERS) activity of these colloids with respect to those obtained by chemical reduction. However, SERS activation can be efficiently obtained by addition of chloride ions to the colloids, leading to SERS enhancement factors that are comparable with those of the chemically prepared counterparts. Copyright © 2015 John Wiley &amp; Sons, Ltd.
Theoretical Study of Population Inversion in Graphene under Pulse Excitation (2011)

We study theoretically the population inversion in intrinsic graphene under optical pulse excitation at room temperature. We develop the theoretical model of carrier relaxation dynamics based on the rate equations derived from the quasi-classical Boltzmann equation. We take into account the energy relaxation and recombination by the intra and interband optical phonon (OP) scattering, and we assume that the carrier–carrier (CC) scattering is dominant so that the carrier distribution is always the quasi-Fermi distribution. Using the model developed, we demonstrate that the population inversion can be achieved under the pulse excitation even in the limiting case of the dominant CC scattering.
Stereoselective Synthesis and Immunogenic Activity of the C-Analogue of Sulfatide (2006)

[Structure: see text] The C-sulfatide 1b was synthesized through a [2,3]-Wittig sigmatropic rearrangement and a Horner-Wadsworth-Emmons olefination as the key steps. The C-analogue 1b is less immunogenic than natural sulfatide 1a, but induces a preferential secretion of the proinflammatory cytokine IFN-gamma.