gebhart/patrepeval huggingface dataset:
The Amphibian Antimicrobial Peptide Uperin 3.5 is a Cross-α/Cross-β Chameleon Functional Amyloid (2020)

Abstract Antimicrobial activity is being increasingly linked to amyloid fibril formation, suggesting physiological roles for some human amyloids, which have historically been viewed as strictly pathological agents. This work reports on formation of functional cross-α amyloid fibrils of the amphibian antimicrobial peptide uperin 3.5 at atomic-resolution, an architecture initially discovered in the bacterial PSMα3 cytotoxin. The fibrils of uperin 3.5 and PSMα3 were comprised of parallel and anti-parallel helical sheets, respectively, recapitulating properties of β-sheets. Uperin 3.5 helical fibril formation was largely induced by, and formed on, bacterial cells or membrane mimetics, and led to membrane damage and cell death. Uperin 3.5 demonstrated chameleon properties, with a secondary structure switch to cross-β fibrils with reduced antibacterial activity in the absence of lipids or after heat shock. These findings suggest a regulation mechanism, which includes storage of inactive peptides as well as environmentally induced activation of uperin 3.5, via chameleon cross-α/β amyloid fibrils.
SU‐FF‐T‐321: Micro‐Computed Tomography: A Tool for the Determination of the Sensitive Volume of Cylindrical and Plane Parallel Ion Chambers (2006)

Purpose: To use micro‐computed tomography (micro‐CT) as a tool for non‐destructive imaging of air ionization chambers for independent sensitive volume determination and quality assurance of the chambers. Methods and Materials: A GE Locus Micro‐CT imaging system was used to acquire high‐resolution images of several common small‐volume chambers (Exradin T11 plane‐parallel chamber and Exradin A1SL cylindrical chamber). Initial scans were taken of these chambers with a 4cm field of view, 80kVp energy, 450μA tube current, 399 views, and 400ms exposure time per view. Images were reconstructed with 89μm pixel size. GE MicroView visualization software was used to determine the chambers' air volumes for comparison with the manufacturer's specifications. The ability of micro‐CT to differentiate materials and the effect of high density materials on image quality was assessed. In addition, four Exradin A1SL cylindrical chambers were imaged with an increased number of views (720) and acquisition angles (360°) and reconstructed with 20μm pixel size. Air volumes from all of the chambers were compared to the chamber relative ionization signals generated in a 10×10cm 2 reference field from a Varian 2100C/D linac. Results: The air cavity volumes derived from the micro‐CT images agreed with nominal volumes given by the manufacturers within 5% for both the cylindrical and plane parallel chambers. The relative response of the cylindrical chambers agreed with the relative volumes (semi‐automatic method) within 2%. The presence of the connecting cables or pins within the chambers did not affect the ability to accurately visualize the sensitive air volumes. Conclusions: Micro‐CT is a promising tool for the measurement of ion chamber air volume and potentially for determining calibration factors for use in dosimetry. These high resolution images could also prove useful as input to Monte Carlo simulations and the calculation of ion chamber response factors from first principles.
Unmanned-Aerial-Vehicle-Aided Integrated Sensing and Computation With Mobile-Edge Computing (2023)

Integrated sensing and communication (ISAC), which enables the joint radar sensing and data communications, shows its great potential in many intelligent applications. In this article, we investigate the unmanned aerial vehicle (UAV)-aided ISAC with mobile-edge computing (MEC), where the ISAC device deployed on the UAV senses multiple targets with the sensing scheduling and offloads the radar sensing data to the edge-server to train a machine learning model for target recognition. The radar estimation information rate is utilized to measure the radar sensing performance. We aim to minimize a systemwise cost that includes both the UAV’s energy consumption and the data collecting time, while satisfying the requirements on both the model training error and the radar sensing performance. We formulate a joint optimization problem of the sensing scheduling, the number of time-slots, the sensing power, the communication power, and the UAV trajectory. Despite the strict nonconvexity of the formulated problem, we propose an efficient algorithm for solving it. Our algorithm jointly leverages the vertical decomposition that exploits the layered structure of the formulated problem and the horizontal decomposition that utilizes the block coordinate descent (BCD) method. Numerical results are presented to validate the effectiveness of our proposed algorithms and show the performance gain of our proposed scheme.
Influences of wind energy on the operation of transmission systems (2008)

In this work the impact of wind energy on the power flow is analyzed. After the development of a reduced sample network, possible network congestions are identified and the costs for the required redispatch of the generation are evaluated. To avoid or reduce the probability of congestions, different network upgrades can be installed. The efficiency of additional lines and power flow controlling devices is discussed on the basis of power flow calculations and dynamic simulations.
Mobile Agent Attack Resistant Distributed Hierarchical Intrusion Detection Systems (1999)

Distributed intrusion detection systems are especially vulnerable to attacks because the components reside at a static location and are connected together into a hierarchical structure. An attacker can disable such a system by taking out a node high in the hierarchy, thus amputating a portion of the distributed system. One solution to this problem is to cast the internal nodes in the system hierarchy as mobile agents. These mobile agents randomly move around the network such that an attacker can not locate their position. If an attacker takes out a mobile agent platform, the remaining agents estimate the location of the attacker and automatically avoid those networks. Killed agents are resurrected by a group of backups that retain all or partial state information. We are implementing this technology as an API such that existing intrusion detection systems can wrap their components as mobile agents in order to gain a type of “attack resistance”. Intrusion detection systems (IDS) are obvious targets for network intruders. Take out the IDS and an attacker can slip invisibly into vulnerable computer systems. This problem becomes more pronounced as commercial IDSs migrate to massively distributed hierarchical architectures. In these systems, an attacker
Higher mortality risk among kidney transplant recipients than among estimated glomerular filtration rate–matched patients with CKD—preliminary results (2020)

Abstract Background Although kidney transplantation prolongs survival relative to dialysis, it is associated with a higher death rate than in the general population. The objective of the present study was to assess and compare the risk of mortality and frequency of non-lethal cardiovascular (CV) events in kidney transplant recipients (KTRs) beyond 1 year after successful transplantation versus patients with chronic kidney disease (CKD) using propensity score–matched analysis of estimated glomerular filtration rate (eGFR) and other parameters. Methods After propensity score matching, we studied 340 KTRs from the French Données Informatisées et Validées en Transplantation cohort and 605 non-transplant patients with CKD (CKDps) from the French Chronic Kidney Disease–Renal Epidemiology and Information Network cohort. The mean ± standard deviation eGFR was 42 ± 13 and 41 ± 12 mL/min/ 1.73 m2, respectively (P = 0.649). Descriptive data were completed by a survival analysis with Cox regression models. Results After a median follow-up period of 2.8 years (KTRs 2.0 years, CKDp 2.9 years), 71 deaths were recorded (31 and 40 in the KTR and CKD groups, respectively). Univariate analysis showed that KTRs had a significantly greater risk of mortality than CKDps. In multivariable analysis, KTRs were found to have a 2.7-fold greater risk of mortality [hazard ratio 2.7 (95% confidence interval 1.6–4.7); P = 0.005]. There was no between-group difference concerning the risk of CV events (P = 0.448). CV death rates in KTRs (29.0%) approximated those of CKDps (22.5%), whereas death rates due to infections were higher in KTRs (19.4% versus 10.0%). Conclusion Beyond 1 year after transplantation, KTRs, who possibly had a longer CKD history, had a significantly greater mortality risk than eGFR-matched CKDps. The excess risk was not associated with CV events.
Biomedical imaging using optical coherent tomography (2002)

Optical Coherence Tomography (OCT) is a new optical technique for performing non-contact, micron resolution, cross sectional tomography imaging in biological systems. The authors discuss applications of OCT to ophthalmology, general medicine, and microscopy.
Cholangiocyte‐derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans (2018)

Cholangiocyte-derived exosomal-H19 plays a critical role in cholestatic liver injury. Serum exosomal H19 represents a noninvasive biomarker and potential therapeutic target for cholestatic diseases. (Hepatology 2018).
Draft Genome Sequence of Methylobacterium sp. Strain V23, Isolated from Accretion Ice of the Antarctic Subglacial Lake Vostok (2018)

Here, we report the draft genome sequence of <i>Methylobacterium</i> sp. strain V23, a bacterium isolated from accretion ice of the subglacial Lake Vostok (3,592 meters below the surface). This genome makes possible the study of ancient and psychrophilic genes and proteins from a subglacial environment isolated from the surface for at least 15 million years.
Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces (2012)

This review article describes fundamental aspects of cell membrane-inspired phospholipid polymers and their usefulness in the development of medical devices. Since the early 1990s, polymers composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) units have been considered in the preparation of biomaterials. MPC polymers can provide an artificial cell membrane structure at the surface and serve as excellent biointerfaces between artificial and biological systems. They have also been applied in the surface modification of some medical devices including long-term implantable artificial organs. An MPC polymer biointerface can suppress unfavorable biological reactions such as protein adsorption and cell adhesion - in other words, specific biomolecules immobilized on an MPC polymer surface retain their original functions. MPC polymers are also being increasingly used for creating biointerfaces with artificial cell membrane structures.
A Basic Study on the Fatigue Estimation Using Voice Analysis (2011)

본 연구는 인간의 피로를 정량적으로 측정할 수 있는 기술을 개발하기 위한 기초 연구로서, 인간의 피로가 음성에 미치는 영향을 파악하기 위해 수행하였다. 실험을 위해 피실험자 8명을 대상으로 4수준의 육체피로 부하(4단계)와 5수준의 모음(아,어,오,우,이)의 조합조건에서 턱 열림의 정도인 제 1 포먼트(F1)주파수와 Borg-RPE 주관적 설문을 사용하였다. 실험결과 육체피로 부하 수준이 높아 질수록 모든 모음 수준에서 제 1 포먼트(F1)주파수의 수치가 유의하게 작아졌고, Borg-RPE 또한 피로의 수준과 함께 높아지는 것으로 분석 되었다. 본 연구의 결과는 음성을 활용하여 인간의 피로를 정량적으로 측정할 수 있는 음성 피로도 평가 시스템을 위한 기초 자료로 이용될 수 있을 것이라 생각된다.
Culex torrentium: A Potent Vector for the Transmission of West Nile Virus in Central Europe (2019)

The continuous circulation of West Nile virus (WNV) in Central, South and East Europe and its recent detection in several dead birds and two horses in Germany highlights the need for information on WNV vector competence of mosquitoes from Central Europe. Therefore, three common <i>Culex</i> species (<i>Culex pipiens</i> biotype <i>pipiens</i>, <i>Culex pipiens</i> biotype <i>molestus</i> and <i>Culex torrentium</i>) from Germany were orally infected with WNV and kept at 18 °C, 21 °C, 24 °C or 27 °C for 14 or 21 days post infection (dpi). Thereafter viable WNV was present in the saliva in all tested taxa, but only at incubation temperatures of 24 °C or 27 °C and predominantly at the extended incubation period of 21 dpi. Highest transmission efficiency rates of 17 % (24 °C) and 24% (27 °C) were found for <i>Cx. torrentium</i>. <i>Culex p. pipiens</i> and <i>Cx. p. molestus</i> showed low transmission efficiencies with a maximum of only 3%. Consequently, temperatures above 21 °C support transmission of WNV, which matches the predominant distribution of human WNV cases around the Mediterranean Sea and in South-East Europe. <i>Culex torrentium</i> has been identified as a potent vector for WNV in Central and Northern Europe, which highlights the need for surveillance of mosquito-borne viruses north of the Alps.
Design for Additive Manufacturing of Cellular Structures (2008)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Zinc and copper carbenoids as efficient and selective a1/d1 multicoupling reagents. 1 (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTZinc and copper carbenoids as efficient and selective a1/d1 multicoupling reagents. 1Paul Knochel, Nakcheol Jeong, Michael J. Rozema, and Ming Chang P. YehCite this: J. Am. Chem. Soc. 1989, 111, 16, 6474–6476Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ja00198a097https://doi.org/10.1021/ja00198a097research-articleACS PublicationsRequest reuse permissionsArticle Views678Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex. (1996)

Coatomer is a cytosolic protein complex that forms the coat of COP I-coated transport vesicles. In our attempt to analyze the physical and functional interactions between its seven subunits (coat proteins, [COPs] alpha-zeta), we engaged in a program to clone and characterize the individual coatomer subunits. We have now cloned, sequenced, and overexpressed bovine alpha-COP, the 135-kD subunit of coatomer as well as delta-COP, the 57-kD subunit and have identified a yeast homolog of delta-COP by cDNA sequence comparison and by NH2-terminal peptide sequencing. delta-COP shows homologies to subunits of the clathrin adaptor complexes AP1 and AP2. We show that in Golgi-enriched membrane fractions, the protein is predominantly found in COP I-coated transport vesicles and in the budding regions of the Golgi membranes. A knock-out of the delta-COP gene in yeast is lethal. Immunoprecipitation, as well as analysis exploiting the two-hybrid system in a complete COP screen, showed physical interactions between alpha- and epsilon-COPs and between beta- and delta-COPs. Moreover, the two-hybrid system indicates interactions between gamma- and zeta-COPs as well as between alpha- and beta' COPs. We propose that these interactions reflect in vivo associations of those subunits and thus play a functional role in the assembly of coatomer and/or serve to maintain the molecular architecture of the complex.
A Diffuse Reflectance Infrared Fourier-Transform Spectra and Density Functional Theory Study of CO Adsorption on Rh/γ-Al2O3 (2007)

The vibrational frequencies and bond dissociation energies of carbon monoxide adsorbed to various rhodium clusters are computed, and the diffuse reflectance infrared Fourier-transform (DRIFT) spectrum of carbon monoxide adsorbed onto Rh/γ-Al2O3 is reported. The computations reveal that the spectral features that have previously been assigned to symmetric and antisymmetric vibrational modes of isolated dicarbonyl species on Rh can also be assigned to vibrational coupling of adjacent linearly bound carbonyl groups (atop M−CO). We explore, in small rhodium clusters, the effects of binding configuration, surface coverage, metal−support charge transfer, and cluster dimension on the vibrational frequency of the C−O bond and the adsorption energy of CO to rhodium. In particular, we find a linear correlation between the vibrational frequency of the carbon−oxygen bond with respect to the metal−carbonyl bond adsorption energy as well as the carbon-oxygen bond length for small rhodium clusters. A semiquantitative relationship is derived that may be used to calculate bond dissociation enthalpies of rhodium−carbonyl bonds with the use of crystallographic or IR data associated to the rhodium−carbonyl bond.
Numerical modeling of heat assisted magnetic recording system (2014)

Heat assisted magnetic recording (HAMR) is envisioned as the next technology for boosting the recording densities. In HAMR, a localized optical field is used to locally heat the magnetic recording media layer, thus reducing the thermal stability and allowing recording at sufficiently weak magnetic fields. After cooling down, the recording layer restores the original high thermal stability. From the simulation point of view HAMR requires integrated modeling approaches, including magnetics, optics, heat transport, and electromagnetics.
Specificity of childhood psychotic symptoms for predicting schizophrenia by 38 years of age: a birth cohort study (2013)

Childhood psychotic symptoms were not specific to a diagnosis of schizophrenia in adulthood and thus future studies of early symptoms should be cautious in extrapolating findings only to this clinical disorder. However, these symptoms may be useful as a marker of adult mental health problems more broadly.
Establishment of Glycosaminoglycan Assays for Mucopolysaccharidoses (2014)

Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders caused by deficiency of the lysosomal enzymes essential for catabolism of glycosaminoglycans (GAGs). Accumulation of undegraded GAGs results in dysfunction of multiple organs, resulting in distinct clinical manifestations. A range of methods have been developed to measure specific GAGs in various human samples to investigate diagnosis, prognosis, pathogenesis, GAG interaction with other molecules, and monitoring therapeutic efficacy. We established ELISA, liquid chromatography tandem mass spectrometry (LC-MS/MS), and an automated high-throughput mass spectrometry (HT-MS/MS) system (RapidFire) to identify epitopes (ELISA) or disaccharides (MS/MS) derived from different GAGs (dermatan sulfate, heparan sulfate, keratan sulfate, and/or chondroitin sulfate). These methods have a high sensitivity and specificity in GAG analysis, applicable to the analysis of blood, urine, tissues, and cells. ELISA is feasible, sensitive, and reproducible with the standard equipment. HT-MS/MS yields higher throughput than conventional LC-MS/MS-based methods while the HT-MS/MS system does not have a chromatographic step and cannot distinguish GAGs with identical molecular weights, leading to a limitation of measurements for some specific GAGs. Here we review the advantages and disadvantages of these methods for measuring GAG levels in biological specimens. We also describe an unexpected secondary elevation of keratan sulfate in patients with MPS that is an indirect consequence of disruption of catabolism of other GAGs.
Higher expression of Bax in regulatory T cells increases vascular inflammation (2008)

This study is to examine our hypothesis that CD4+CD25(high)Foxp3+ regulatory T cells (Tregs) have an interleukin-2 (IL-2) withdrawal-triggered apoptosis pathway, and modulation of Treg apoptosis pathway affects development of vascular inflammation. We found that pro-apoptotic protein Bax upregulation in Tregs is induced by IL-2 withdrawal. Treg apoptosis induced by IL-2 withdrawal is inhibited by a Bax inhibitor, suggesting that highly expressed Bax is functional. To define the role of upregulated Bax in Treg apoptosis, we established a Tregs-specific Bax transgenic mouse model. Enforced expression of Bax in Tregs promotes Treg apoptosis triggered by IL-2 withdrawal and other apoptosis stimuli, suggesting pro-apoptotic role of highly expressed Bax in wild-type Tregs. Finally, higher expression of Bax in Tregs decreases the striking threshold of vascular inflammation due to the failure of suppression of inflammatory cells resulting from Treg apoptosis. These results have demonstrated the proof of principle that the modulation of Tregs apoptosis/survival could be used as a new therapeutic approach for inflammatory cardiovascular diseases.
Modélisation multi-échelle et expérimentation du μ-usinage et du μ-contact outil-copeau (2019)

International audience
AC magnetorheology of polymer magnetic composites (2022)

One-step magnetocuring and AC-magnetorheology of AMF susceptible materials.
Cardiorespiratory Effects and Kinetics of Intrathecally Injected D-Ala2-D-Leu5-Enkephalin and Morphine in Unanesthetized Dogs (1986)

In unanesthetized dogs prepared with chronic tracheostomies and chronically implanted intrathecal (IT) catheters having openings in the cisterna magna and lumbar region, lumbar IT injection of D-Ala2-D-Leu5-enkephalin (DADL, 1-10 mg) and morphine (3-30 mg) produced a dose-dependent depression of the slope of the CO2 response function (minute expired volume [VE] vs. end-tidal [ET] CO2) as investigated by a modified Read rebreathing technique. The maximum depression occurred less than 3 h after IT injection of either agent and lasted as long as 12 h. The depression was totally reversed by naloxone (0.4 mg/kg, iv). Naloxone alone had no effect on ventilatory function. After 10 mg DADL, there was no significant change in heart rate (HR), mean arterial pressure (MAP), mean pulmonary artery pressure (MPAP), cardiac output (CO), systemic vascular resistance (SVR), pulmonary vascular resistance (PVR), or PaO2 during the 3 h postinjection. In contrast, PaCO2 was significantly elevated and pH significantly decreased (P less than 0.05). Naloxone administration after high-dose IT DADL resulted in a doubling of MABP, MPBP, CO, and SVR that lasted approximately 20 min. In concurrently measured cisternal cerebrospinal fluid (CSF) levels, both morphine and DADL displayed peak levels by 30-60 min. The lumbar CSF clearance curves for both agents were fitted with a two-compartment intravenous bolus model. The t 1/2 alpha was 13.8 +/- 3.6 min for DADL and 9.4 +/- 1.6 min for morphine (mean +/- SE). The t 1/2 beta was 101.3 +/- 17.7 min for DADL and 116.7 +/- 27.9 min for morphine.(ABSTRACT TRUNCATED AT 250 WORDS)