gebhart/patrepeval huggingface dataset:
Design research methods to understand user needs for an etextile knee sleeve (2013)

Knee replacement surgery is dramatically increasing in the United States for people over the age of 45 and rehabilitation after surgery is a necessary step for the success of the replacement. Rehabilitation requires regular access to a wide variety of resources and personnel. Currently, there are no self-care tools to enable tracking a patient's rehabilitative progress at home. As such, there is an opportunity to design and develop sensing technology tools to help alleviate the healthcare system and empower people in the knee rehabilitation process. The purpose of this paper is to describe the design process for a wearable, home rehabilitation device for knee replacement: an eTextile Knee Sleeve. More specifically, it describes the design research methods undertaken to understand user needs, including expert interviews, rehabilitation observation, and a participatory design workshop, to leverage advancements in technology and the field of eTextiles.
Pervasive Computing for the 99% (2011)

A key limiting factor for the pervasive community has been the difficulty developing and deploying general purpose systems. Such systems should make application development easy, support a wide range of devices and sensors, and allow users to share these resources. Designing a multi-user middleware system that allows novice users to add arbitrary hardware and software raises several challenges, such as resolution between conflicting and stale data, managing data dependencies as software and hardware is changed, and tradeoffs between complexity and expressiveness in the API of such a system. We will discuss the feature set that could solve these problem, and test these features through a software implementation. We then evaluate the system after a year long deployment supporting smart office applications.
Photochemical, Metal‐Free Sigmatropic Rearrangement Reactions of Sulfur Ylides (2019)

Sigmatropic rearrangement reactions constitute one of the most fundamental reactions of carbenes. While state-of-the-art synthetic methods require the use of expensive precious metal catalysts, the application of visible light for the photolysis of α-aryldiazoacetates is much less investigated and provides an operationally simple entry to carbenes under mild reaction conditions. Herein, we report on blue-light induced sigmatropic rearrangement reactions of sulfur compounds with α-aryldiazoacetates. This process, depending on the substitution pattern of the sulfide, opens up formal insertion reactions of carbenes into S-N, S-C, or C-H bonds.
Class II Composite Restorations and Proximal Concavities: Clinical Implications and Management (2012)

Clinical experience supports the notion that the restoration of MOD cavities may pose a challenge to the practitioner. Proper placement of precontoured matrices and commercial wedges help the clinician to establish an optimal emergence profile and sufficient contours. However, the presence of proximal concavities in premolars or molars can turn the reproduction of previous cervical architecture into an even more demanding task. Wedges with customized form or adequate design can precisely conform the matrix to the cavosurface area and prevent any gap formation. This article presents two different options that allow for successful and predictable reestablishing of anatomically correct contours and optimal proximal contacts in posterior teeth with proximal concavities.
What is the lowest refractive index of an organic polymer? (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWhat is the lowest refractive index of an organic polymer?W. Groh and A. ZimmermannCite this: Macromolecules 1991, 24, 25, 6660–6663Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ma00025a016https://doi.org/10.1021/ma00025a016research-articleACS PublicationsRequest reuse permissionsArticle Views2813Altmetric-Citations189LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vertical Permeability Measurement in New Reservoirs Using Tidal Pressure Changes (1990)

ABSTRACT A new method of measuring vertical permeability is presented and successfully tested with field data. It takes advantage of naturally induced tidal pressure changes that occur in all reservoirs and can therefore be used at the appraisal stage. A single well drilled through a gas liquid contact is required - ideally in an offshore field. The pore volume compressibility is also measured using tidal data and compared with core measurements.
Nanotechnology in Biological Agent Decontamination (2005)

This chapter contains sections titled: Introduction Standard Methods for Chemical Decontamination of Biological Agents Nanomaterials for Decontamination Magnesium Oxide Mechanism of Action Titanium Dioxide Summary
A New Call Admission Control Scheme for Heterogeneous Wireless Networks (2010)

Call Admission Control (CAC) between heterogeneous networks, such as an integrated 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) network and a Wireless Local Area Network (WLAN), plays an important role to utilize the system resources in a more efficient way. In this paper, we propose that the preference to the WLAN is determined based on the traffic load in the WLAN and the location of the cellular users. Our analysis relies on a previous study that divides the 3G cellular coverage area into zones based on the amount of resources that are required to support a connection to a mobile user. Using this model, we derive new call blocking and handoff failure probabilities as well as new call and handoff attempt failure probabilities. Through simulations, we investigate proper preference settings by changing the WLAN load in a 3 ring-based sector with a WLAN hotspot.
Molecular methods for diagnosis of monkeypox: A mini-review (2022)

ABSTRACT Background Monkeypox is a global public health issue caused by the monkeypox virus (MPXV), a virus belonging to the Orthopoxvirus genus. As of October 28 2022, a total of 77,115 laboratory-confirmed cases and 3,610 probable cases, including 36 deaths, were reported, with 9,070 cases reported in Brazil, the second most affected country. The need to develop national technologies for the rapid diagnosis of emerging diseases for mass testing of the population is evident, as observed in the current SARS-CoV-2 pandemic. With that in mind, this article provides an overview of current methods, techniques, and their applications in the molecular detection of monkeypox. Methods The relevant documents or papers covered in this study were selected by a search in international bibliographic databases. The search terms used in the databases were aimed at summarizing existing knowledge on molecular diagnostic methods, such as: monkeypox; MPX, MPXV, qPCR, PCR, PCR-ELISA, and Diagnosis and Detection searched separately or together using the Boolean operator “AND” either in the title or abstract. The searches took place in September 2022, and the corresponding articles were selected between 2012 and 2022. Results We found 256 documents in total and twelve studies addressing the molecular diagnosis of monkeypox were classified as possible sources for this review. Conclusion This paper presents new perspectives and an overview of current methods, technologies, and applications in the molecular diagnosis of monkeypox. It is evident there is a pressing need to develop national technologies for the rapid diagnosis of emerging diseases for mass testing of the population. It is extremely important to have national detection kits with greater diagnostic capacity to assist in developing effective public policies in countries affected by this disease.
Expression of a human polyomavirus oncoprotein and tumour suppressor proteins in medulloblastomas (2001)

<i>Aims</i>—Although the aetiology of medulloblastoma remains elusive, several lines of evidence suggest an association with the human neurotropic polyomavirus JC and its oncoprotein T antigen. The tumour forming properties of JC virus T antigen are the result, at least in part, of its ability to bind and inactivate tumour suppressor/cell cycle regulatory proteins, such as p53 and the retinoblastoma family of proteins. <i>Methods</i>—To examine potential relations between these factors, immunohistochemistry was used to determine associations between the T antigen and the expression of p53 and the retinoblastoma proteins pRb, p107, and Rb2/p130 in eight medulloblastomas. <i>Results</i>—Only the three medulloblastomas with T antigen expression also showed nuclear positivity with antibodies to p53. Although immunohistochemistry detected nuclear labelling for pRb in five of the cases, the three that were positive for T antigen showed the highest pRb labelling. The retinoblastoma related proteins p107 and Rb2/p130 were also immunopositive in most T antigen positive medulloblastomas. Double label immunohistochemistry also demonstrated p53 and pRb positivity in the same cells that were T antigen positive. <i>Conclusions</i>—These correlations suggest that associations between T antigen and p53 and/or T antigen and pRb occur in some of these tumours. These data provide indirect evidence that JC virus, acting through T antigen, might be involved in the formation and progression of medulloblastoma.
Identification of a molecular gating determinant within the carboxy terminal region of Cav3.3 T-type channels (2019)

The physiological functions controlled by T-type channels are intrinsically dependent on their gating properties, and alteration of T-type channel activity is linked to several human disorders. Therefore, it is essential to develop a clear understanding of the structural determinants responsible for the unique gating features of T-type channels. Here, we have investigated the specific role of the carboxy terminal region by creating a series a deletion constructs expressed in tsA-201 cells and analyzing them by patch clamp electrophysiology. Our data reveal that the proximal region of the carboxy terminus contains a structural determinant essential for shaping several gating aspects of Ca<sub>v</sub>3.3 channels, including voltage-dependence of activation and inactivation, inactivation kinetics, and coupling between the voltage sensing and the pore opening of the channel. Altogether, our data are consistent with a model in which the carboxy terminus stabilizes the channel in a closed state.
Using Magnetically Responsive Tea Waste to Remove Lead in Waters under Environmentally Relevant Conditions (2013)

We report the use of a simple yet highly effective magnetite-waste tea composite to remove lead(II) (Pb 2+ ) ions from water. Magnetite-waste tea composites were dispersed in four different types of water-deionized (DI), artificial rainwater, artificial groundwater and artificial freshwater-that mimic actual environmental conditions. The water samples had varying initial concentrations (0.16-5.55 ppm) of Pb 2+ ions and were mixed with the magnetite-waste tea composite for at least 24 hours to allow adsorption of the Pb 2+ ions to reach equilibrium. The magnetite-waste tea composites were stable in all the water samples for at least 3 months and could be easily removed from the aqueous media via the use of permanent magnets. We detected no significant leaching of iron (Fe) ions into the water from the magnetite-waste tea composites. The percentage of Pb adsorbed onto the magnetite-waste tea composite ranged from ,70% to 100%; the composites were as effective as activated carbon (AC) in removing the Pb 2+ ions from water, depending on the initial Pb concentration. Our prepared magnetite-waste tea composites show promise as a green, inexpensive and highly effective sorbent for removal of Pb in water under environmentally realistic conditions.
Extraction of BMAA from Cyanobacteria (2016)

In order for proper analysis of cyanobacterial toxins, extraction methods are required to release toxins from cells. Various extraction techniques are used for different cyanotoxins. β-N-Methylamino-l-alanine has been found as a free amino acid and as a bound component in cyanobacteria. This SOP provides instruction for the extraction of both components from cyanobacterial cells.
Development of a flow cell based Raman spectroscopy technique to overcome photodegradation in human blood (2019)

Raman spectroscopy of blood offers significant potential for label-free diagnostics of disease. However, current techniques are limited by the use of low laser power to avoid photodegradation of blood; this translates to a low signal to noise ratio in the Raman spectra. We developed a novel flow cell based Raman spectroscopy technique that provides reproducible Raman spectra with a high signal to noise ratio and low data acquisition time while ensuring a short dwell time in the laser spot to avoid photodamage in blood lysates. We show that our novel setup is capable of detecting minute changes in blood lysate spectral features from natural aging. Moreover, we demonstrate that by rigorously controlling the experimental conditions, the aging effect due to natural oxidation does not confound the Raman spectral measurements and that blood treated with hydrogen peroxide to induce oxidative stress can be discriminated from normal blood with a high accuracy of greater than 90% demonstrating potential for use in a clinical setting.
Low Nitrogen Losses with a New Source of Nitrogen for Cultivation of Conifer Seedlings (2002)

Losses of nitrogen (N) when cultivating plants may cause a number of adverse environmental effects. N losses from conifer nurseries, for instance, may have a considerable impact on the local environment, and studies indicate that the bulk of added N is not recovered in the cultivated plants. This study was conducted to obtain insight into the causes of the low recovery and to test an alternative N fertilizer. Hence, growth of the economically important Scots pine (Pinus sylvestris (L).) seedlings and the recovery of different forms of added nitrogen (N) were investigated in a greenhouse experiment. Containerized seedlings were grown in peat for one summer, with two different N fertilizers, one organic (arginine) and one inorganic (a commercial fertilizer (CF) containing a mixture of ammonium and nitrate) each at an N concentration of 3 mM. At the end of the growth period, some seedlings were labeled with solutions containing either U-[13C6], [15N4]-arginine, (15NH4)2SO4, or K15NO3 supplied to the growth substrate. Labeled seedlings were harvested 1 h, 5 days, and 19 days after tracer addition, and the recovery of each added nitrogen source in both the seedlings and the growth substrate was measured. The retention of the three N forms during discharge of solutions from the growth substrate, peat, was tested in a separate experiment. Arginine-fed seedlings grew better and had higher needle N concentrations than the CF-fed seedlings. Isotopic data showed that the arginine treatment gave significantly higher N recoveries (80%) compared to the CF treatment (50%). The low recovery of N in the CF treatment was largely due to very low recovery (30%) of NO3- -N. The retention of the different N forms during discharge of solutions from the growth substrate was highest for arginine, somewhat lower for NH44+, and very low for NO3-. The high rate of seedling growth and the small nitrogen losses observed when using arginine suggest that this amino acid may be an efficient and environmentally favorable N source for cultivating conifer seedlings.
Neural Wave Functions for Superfluids (2023)

Understanding superfluidity remains a major goal of condensed matter physics. Here we tackle this challenge utilizing the recently developed Fermionic neural network (FermiNet) wave function Ansatz [D. Pfau et al., Phys. Rev. Res. 2, 033429 (2020).] for variational Monte Carlo calculations. We study the unitary Fermi gas, a system with strong, short-range, two-body interactions known to possess a superfluid ground state but difficult to describe quantitatively. We demonstrate key limitations of the FermiNet Ansatz in studying the unitary Fermi gas and propose a simple modification based on the idea of an antisymmetric geminal power singlet (AGPs) wave function. The new AGPs FermiNet outperforms the original FermiNet significantly in paired systems, giving results which are more accurate than fixed-node diffusion Monte Carlo and are consistent with experiment. We prove mathematically that the new Ansatz, which only differs from the original Ansatz by the method of antisymmetrization, is a strict generalization of the original FermiNet architecture, despite the use of fewer parameters. Our approach shares several advantages with the original FermiNet: the use of a neural network removes the need for an underlying basis set; and the flexibility of the network yields extremely accurate results within a variational quantum Monte Carlo framework that provides access to unbiased estimates of arbitrary ground-state expectation values. We discuss how the method can be extended to study other superfluids.
Induction of Differentiation in Normal Human Keratinocytes by Adenovirus-Mediated Introduction of the η and δ Isoforms of Protein Kinase C (1998)

Protein kinase C (PKC) plays a crucial role(s) in regulation of growth and differentiation of cells. In the present study, we examined possible roles of the alpha, delta, eta, and zeta isoforms of PKC in squamous differentiation by overexpressing these genes in normal human keratinocytes. Because of the difficulty of introducing foreign genes into keratinocytes, we used an adenovirus vector system, Ax, which allows expression of these genes at a high level in almost all the cells infected for at least 72 h. Increased kinase activity was demonstrated in the cells overexpressing the alpha, delta, and eta isoforms. Overexpression of the eta isoform inhibited the growth of keratinocytes of humans and mice in a dose (multiplicity of infection [MOI])-dependent manner, leading to G1 arrest. The eta-overexpressing cells became enlarged and flattened, showing squamous cell phenotypes. Expression and activity of transglutaminase 1, a key enzyme of squamous cell differentiation, were induced in the eta-overexpressing cells in dose (MOI)- and time-dependent manners. The inhibition of growth and the induction of transglutaminase 1 activity were found only in the cells that express the eta isoform endogenously, i.e., in human and mouse keratinocytes but not in human and mouse fibroblasts or COS1 cells. A dominant-negative eta isoform counteracted the induction of transglutaminase 1 by differentiation inducers such as a phorbol ester, 1alpha,25-dihydroxyvitamin D3, and a high concentration of Ca2+. Among the isoforms examined, the delta isoform also inhibited the growth of keratinocytes and induced transglutaminase 1, but the alpha and zeta isoforms did not. These findings indicate that the eta and delta isoforms of PKC are involved crucially in squamous cell differentiation.
ChemInform Abstract: Pd Nanoparticles for C—C Coupling Reactions (2011)

Abstract Review: ca. 100 refs.
Predicting risk of death from cardiovascular disease - Reply (2001)

In reply to White, extrapolating risk scores to ages over 75 is desirable, but our data (like those of others) include few such elderly subjects.The benefits of stopping smoking are not immediate so recent
ALTERNATIVES TO SPINAL FUSION (1998)

Techniques have changed significantly with the advent of less invasive surgical techniques for disc excision and spinal fusion; these include the development of rigid internal fixation devices using multiple points of fixation and the better knowledge of the biology of spinal fusion. Despite these improvements in technology, room exists for alternative forms of surgical treatment because of significant failures particularly related to spinal fusions.
FPGA-based accelerator for losslessly quantized convolutional neural networks (2017)

Convolutional Neural Networks (CNN) have been widely used for various computer vision tasks. While GPUs are the most common platform for CNN implementation, FPGAs are promising alternatives to provide better energy efficiency. Recent work demonstrates the potential of network quantization to reduce the model size and enhance computation efficiency while maintaining comparable accuracy to the full precision counterparts. Quantized CNN is especially suitable for FPGA implementation due to the presence of values with non-trivial bitwidth. In this paper, we present the design of an FPGA-based accelerator for losslessly quantized CNNs using High Level Synthesis tool. The experiment result shows that our design achieves 12.9 GOPS/Watt for quantized Alexnet on Imagnet Dataset.
Abstract 18898: Abnormal Conduction and Arrhythmias Precede the Development of Dilated Cardiomyopathy in D1275n Mutant Mice (2016)

Background: The D1275N SCN5A mutation is associated with dilated cardiomyopathy (DCM) in humans. We have previously reported that in 12 week old mice carrying humanized SCN5A alleles, DCM is evident by echo in those homozygous for D1275N (DN/DN) compared to those homozygous for the wild-type allele (H/H), with striking conduction slowing and disorganization by ECG. The present experiments were designed establish the time course of these defects to further understand the pathophysiology of D1275N-related DCM. Methods and Results: By 3 weeks, QRS duration was markedly prolonged and disorganized in DN/DN mice (HH, n=11, 9.8 ± 0.2; DN/DN, n=9, 22.3 ± 2.2 P<0.05) and optical mapping at 3 and 10 weeks showed slow, dyssynchronous conduction in DN/DN mice. However, at 3 weeks, there was no significant difference in ejection fraction or heart rate. Indices of calcium handling were also near-identical in DN/DN and H/H mice, and there were no differences in alpha-actinin, ryanodine receptor, dystrophin, and syntroph...
Engineered microneedle arrays for transcutaneous HIV vaccine delivery (2012)

Background Needle-free delivery has the potential to enhance vaccine efficacy and safety, as well as facilitate cost-effective global vaccine distribution and storage. To this end, microneedle arrays provide the ability for pain-free, safe, and convenient materials delivery through disruption of the outer layers of the skin to access potent immunecompetent cell populations residing within the epidermal/dermal tissues.
Metal-Free N–H Insertions of Donor/Acceptor Carbenes (2012)

Synthetically useful transformations arise from the thermal decomposition of aryldiazoacetates in the presence of primary and secondary amines without the use of a metal catalyst. Thermally generated, free donor/acceptor carbenes directly undergo N-H insertion with amines through selective aza-ylide formation to afford a variety of α-amino esters in 53-96% yields.