gebhart/patrepeval huggingface dataset:
Cardiorespiratory-Based Sleep Staging in Subjects With Obstructive Sleep Apnea (2006)

A cardiorespiratory-based automatic sleep staging system for subjects with sleep-disordered breathing is described. A simplified three-state system is used: Wakefulness (W), rapid eye movement (REM) sleep (R), and non-REM sleep (S). The system scores the sleep stages in standard 30-s epochs. A number of features associated with the epoch RR-intervals, an inductance plethysmography estimate of rib cage respiratory effort, and an electrocardiogram-derived respiration (EDR) signal were investigated. A subject-specific quadratic discriminant classifier was trained, randomly choosing 20% of the subject's epochs (in appropriate proportions of W, S and R) as the training data. The remaining 80% of epochs were presented to the classifier for testing. An estimated classification accuracy of 79% (Cohen's kappa value of 0.56) was achieved. When a similar subject-independent classifier was trained, using epochs from all other subjects as the training data, a drop in classification accuracy to 67% (kappa = 0.32) was observed. The subjects were further broken in groups of low apnoea-hypopnea index (AHI) and high AHI and the experiments repeated. The subject-specific classifier performed better on subjects with low AHI than high AHI; the performance of the subject-independent classifier is not correlated with AHI. For comparison an electroencephalograms (EEGs)-based classifier was trained utilizing several standard EEG features. The subject-specific classifier yielded an accuracy of 87% (kappa = 0.75), and an accuracy of 84% (kappa = 0.68) was obtained for the subject-independent classifier, indicating that EEG features are quite robust across subjects. We conclude that the cardiorespiratory signals provide moderate sleep-staging accuracy, however, features exhibit significant subject dependence which presents potential limits to the use of these signals in a general subject-independent sleep staging system.
The injured larynx: a new surgical procedure for repair. (1976)

This case illustrates an instance by which serious stricture of the subglottic lumen was repaired by a composite pedicle graft. A half circular portion of the normal clavicle cortical bone was incorporated in a regional full-thickness pedicle graft. A defect in the cricoid cartilage and adjacent tissues was thus repaired successfully, preserving the patient's physiologic integrity as to breathing, speaking, coughing, eating, and drinking.
Osteoblast response to plasma‐spray porous Ti6Al4V coating on substrates of identical alloy (2006)

We have evaluated the in-vitro biocompatibility of Ti6Al4V alloy coated by plasma spraying with an identical alloy. These surfaces are widely used in cementless prosthetic components, although osteoblasts behavior on this treated alloy has not been evaluated to date. Cross sectional examination revealed a thick and rough coating of identical composition without sign of delamination. Within the coating, small discontinuities and nonconnected pores were observed. Osteoblast response was evaluated by assessing cell adhesion, proliferation, and differentiation of primary cultures of human osteoblastic cells. Compared to the polished alloy, osteoblast adhesion measured as cell attachment and actin network reorganization was delayed on the plasma-sprayed surface. Cell proliferation and viability were also impaired on the rough surface. Several informative markers of osteoblastic differentiation such as procollagen I peptide, alkaline phosphatase, osteocalcin, osteoprotegerin, and mineralized nodule formation were evaluated and indicated that the plasma-sprayed alloy favored a more differentiated phenotype than polished alloy. Taken together, our in vitro results indicate that successful osseointegration of plasma spraying of Ti6Al4V with an identical alloy is mediated by modulation of osteoblastic differentiation and mineralization.
Surrogate materials for calibration and control: the use of latex particles as calibrants for red cell volume measurements. (1990)

Latex particles, including BCR Certified Reference Material CRM 166a, have important applications for checking linearity and for calibrating aperture-impedance instruments used to determine red-cell volumes. Studies performed on Coulter Counters, e.g. the ZBi/C1000, ZM/C256 and Model S Plus IV, using a series of three different mono-sized latex particles have shown linearity but non-zero intercepts. This emphasizes the importance of calibrating instruments at more than one point. Latex particles also have an important role in calibration of red-cell volume measurements provided that a relative latex: red-cell shape factor has been assigned when the instrument is calibrated with fresh blood. Such relative shape factors are independent of latex particle size but need to be specific for instrument type and probably also for the orifice and diluent to be used. Nevertheless latex calibrants can serve an important role in standardizing red-cell volume measurements.
Antibiotics-Peptide Conjugates Against Multidrug-resistant Bacterial Pathogens (2018)

The menace of multi-drug resistance by bacterial pathogens that are responsible for infectious diseases in humans and animals cannot be over-emphasized. Many bacteria develop resistance to antibiotics by one or more combination of resistance mechanisms namely, efflux pump activation thereby reducing bacteria intracellular antibiotic concentration, synthesizing a protein that protects target site causing poor antibiotic affinity to the binding site, or mutations in DNA and topoisomerase gene coding that alters residues in the binding sites. The ability to use a combination of these resistance mechanisms among others creates a phenomenon known as antimicrobial drug resistance. The development of a new class of antibiotics to address bacterial resistance will require many resources, such as time-consuming effort and high cost associated with commercial risk. Hence, the researchers have adopted a strategic approach to enhance the antibacterial efficacy of existing antibiotics by conjugation or combination of existing antibiotics. A number of peptides have become known as antibacterial, cell-penetrating, or membrane-active agents. Antibiotics-Peptide Conjugates (APCs) are a combination of known antibiotics with a peptide connected through a linker. The rationale is to produce an alternative multifunctional antimicrobial compound that will elicit synergistic antibacterial activities while reducing known shortcomings of antibiotics or peptides, such as cellular penetration, serum instability, cytotoxicity, hemolysis, and instability in high salt conditions. In this review, we overview APCs which are used, as a strategy to combat the menace of multi-drug resistance of bacterial pathogens. Furthermore, we explain the focus area of adopted APC strategies and physicochemical properties data that show how they can be used to improve antibacterial efficacy.
LYMPHOID HYPERPLASIA OF THE LARGE INTESTINE ASSOCIATED WITH DYSGAMMAGLOBULINEMIA (1970)

LYMPHOID HYPERPLASIA OF THE LARGE INTESTINE ASSOCIATED WITH DYSGAMMAGLOBULINEMIA REPORT OF A CASEJ. J. WOLFSON, M.D., G. GOLDSTEIN, M.D., W. KRIVIT, M.D. and R. HONG, M.D.Audio Available | Share
Testbed design for in-vitro characterisation of biomimetic vocal folds (2021)

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Automated DNA electrophoresis, hybridization and detection (1986)

A fully automated, computer controlled system for nucleic acid hybridization analysis has been devised and constructed. In practice, DNA is digested with restriction endonuclease enzyme(s) and loaded into the system by pipette; /sup 32/P-labelled nucleic acid probe(s) is loaded into the nine hybridization chambers. Instructions for all the steps in the automated process are specified by answering questions that appear on the computer screen at the start of the experiment. Subsequent steps are performed automatically. The system performs horizontal electrophoresis in agarose gel, fixed the fragments to a solid phase matrix, denatures, neutralizes, prehybridizes, hybridizes, washes, dries and detects the radioactivity according to the specifications given by the operator. The results, printed out at the end, give the positions on the matrix to which radioactivity remains hybridized following stringent washing.
Dynamical Transition in polypeptides (2008)

In this research article, Zr-MOFs based copper complex as a novel heterogeneous and porous catalyst was designed and prepared. The structure of catalyst has verified by various techniques such as FT-IR, XRD, SEM, N<sub>2</sub> adsorption-desorption isotherms (BET), EDS, SEM-elemental mapping, TG and DTG analysis. UiO-66-NH<sub>2</sub>/TCT/2-amino-Py@Cu(OAc)<sub>2</sub> was used as an efficient catalyst in the synthesis of pyrazolo[3,4-b]pyridine-5-carbonitrile derivatives. The aromatization of titled molecules is performed via a cooperative vinylogous anomeric-based oxidation both under air and inert atmospheres. The unique properties of the presented method are short reaction time, high yield, reusability of catalyst, synthesis of desired product under mild and green condition.
Advanced National Seismic System delivers improved information (2006)

The Advanced National Seismic System (ANSS),an initiative begun in 1998 to integrate, expand, and modernize seismic monitoring nationwide, is providing improvements in earthquake monitoring and in the development, production, and delivery of earthquake data, information, and science. The ANSS initiative is an element of the Earthquake Hazard Program (EHP) of the U.S.Geological Survey (USGS). The USGS National Earthquake Information Center (NEIC),an integral part of ANSS, has incorporated into its routine operations many of the developments in data processing and data products supported by the ANSS. The four principal elements of ANSS monitoring operations are, in sequence: data collection, data processing, generation of data products, and product dissemination. This article describes the current status and new developments in each of these elements, and how they have affected NEIC capabilities.
Comparison of a Hydraulic Vane Actuator With Oil and Water (2001)

Abstract The aim of this paper is to compare the performance of a hydraulic vane actuator with oil and water as the pressure medium. If the same performance level can be achieved with water and oil hydraulics, water as the pressure medium is preferred in applications where external oil leakage is not allowed or in applications that need fireproof fluids. In order to compare the performance, a theoretical analysis of the actuator characteristics is carried out. The analysis includes a linear model of the hydraulic drive and allows identifying which factors should be analyzed in detail. As a result of this study, the parameters that greatly affect the performance of a hydraulic drive are identified (mainly, natural frequency, leakage, friction, damping and servovalve behaviour). To experimentally verify the influence of these factors on the behaviour of the vane actuator, a set of measurements is designed to be able to identify the critical parameters. During this study, special attention is paid to friction and leakage effects. Due to the lower water viscosity, sealing of the fluid chambers is difficult and internal leakage is difficult to avoid.
Fractional Laplacian pyramids (2009)

We provide an extension of the L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -spline pyramid (Unser et al., 1993) using polyharmonic splines. We analytically prove that the corresponding error pyramid behaves exactly as a multi-scale Laplace operator. We use the multiresolution properties of polyharmonic splines to derive an efficient, non-separable filterbank implementation. Finally, we illustrate the potentials of our pyramid by performing an estimation of the parameters of multivariate fractal processes.
Approximation Errors and Model Reduction in Three-Dimensional Diffuse Optical Tomography (2012)

We apply the Bayesian approximation error model for treatment of model reduction by domain truncation and coarse computation mesh in diffuse optical tomography. The approach is tested with a three-dimensional example using experimental data.
Exact Solutions of One-Dimensional TGV (2013)

L2-TGV-regularization has been introduced by Bredies, Kunisch, and Pock. This regularization method requires careful tuning of two regularization parameters. The focus of this paper is to derive analytical results, which allow for characterizing parameter settings, which make this method in fact different from L2-TV (the ROF-model) and L2-TV2 regularization, respectively. In this paper we also provide explicit solutions of TGV-denoising for particular one-dimensional function data.
Comparison of the Immunopotentiating Activity with Structural Characteristics among Water-soluble Polysaccharides Isolated from the Genus Bifidobacterium (1998)

The whole cells (WC) of three strains of bifidobacteria, Bifidobacterium adolescentis M101-4 (M101-4), B. pseudocatenulatum MBL8320 (MBL8320) and B. catenulatum MBL8318, were transformed into water-soluble and insoluble fractions (SF and IF, respectively) having mitogenic activity in murine splenocytes assay in vitro. A soluble high-molecular weight fraction (SHF) with mitogenic activity was successfully isolated from the SF by the following 6-step procedure: proteinase K treatment, ultrafiltration through a 50 kDa cut-off membrane filter, anion-exchange chromatography, dialysis, ultrafiltration through a 6 kDa cut-off membrane filter, and gel-filtration chromatography. The SHF obtained from the three strains were found to consist of polysaccharides containing -4Gal p 1-(and/or -5Gal f 1-) and -6Glc p 1- as the major residues, and Gal f 1- and -6Gal f 1- as characteristic galactofuranosyl residues by their analytical data. β- Glucosidase digestion of the high-molecular weight fractions after proteinase K treatment led to a decrease in the mitogenic activity for splenocytes, suggesting that β-glucosyl residue in the polysaccharides may play an important role in immunopotentiating activity.
Learning the local molecular pattern of Alzheimer's disease by non-negative matrix factorization (2010)

Gene microarray technology is an effective tool to monitor simultaneous activity of multiple cellular pathways from thousands of genes in a single chip. Many clustering methods have been developed to identify groups of genes or experimental conditions that exhibit similar expression patterns from gene expression data, such as hierarchical clustering, k-means, and self-organizing maps (SOM). The limitations of these clustering algorithms are: they group genes (or conditions) based on global similarities in their expression profiles and only assign each gene to a single cluster. In this work we present a biclustering method-nonnegtive matrix factorization (NMF) to avoid the above drawbacks and discover the local molecular pattern from gene expression datasets of Alzheimer's disease (AD). NMF can be applied to reduce the dimensionality of the data and describe the data as a positive linear combination of a reduced number of factors. By applying a sparseness enforcement variable into classical NMF, the more local structures with meaningful biological information inherent in the data are captured by clustering genes and samples simultaneously, and the classification of samples is well improved. The analysis and discussion of the identified local structures demonstrated that they related many pathways which play a prominent role in AD and the activation patterns to AD phenotypes.
Reactivity patterns of mAb 18B7, 18B7dg and chAb 18B7 against polyreactive antigens. (2015)

&lt;p&gt;Panels correspond to the binding profiles of these Abs to, &lt;i&gt;A&lt;/i&gt;, tubulin, &lt;i&gt;B&lt;/i&gt;, ssDNA, &lt;i&gt;C&lt;/i&gt;, thyroglobulin and &lt;i&gt;D&lt;/i&gt;, actin. Human (hIgG1) and mouse (mIgG1) IgG1 were used as control. Data represent mean±SD of three measurements.&lt;/p&gt;
Modulating effect of vitamin D status on serum anti-adenovirus 36 antibody amount in children with obesity: National Food and Nutrition Surveillance (2020)

Abstract Background. The association of ADV-36 infection and obesity has been reported in children. The objective of this study was to examine the hypothesis that the association between ADV-36 infection and adiposity may be mediated by sub-optimal vitamin D status of the host. Methods. Ninety one apparently healthy children in different weight categories (normal weight: 33, overweight: 33, obesity: 25) aged 5-18 years were randomly selected from the registered population at National Food and Nutrition Surveillance Program (NFNS). The groups were matched based on age and sex. Anthropometric, biochemical and serological assessments were performed. Results. The amount of anti-ADV36-Ab increased whereas circulating concentrations of 25(OH)D decreased across BMI categories with higher amounts in children with normal weight than in children with overweight and obesity (31.0±16.4, 22.5±10.5 and 21.9±9.8 nmol/L, respectively, p=0.004). Logistic regression analysis revealed that for each unit increment of anti-ADV36-Ab, the chance of increase in weight was 8.5 times (OR: 8.5, p=0.029). Interestingly, when 25(OH)D was introduced into the model, anti-ADV36-Ab was no longer the predictor of weight increment and the chance of increase in weight reduced 5% for each unit increase in 25(OH)D concentration (OR: 0.95, p=0.012). Conclusion. It is suggested that ADV36-induced lipogenesis may be mediated by vitamin D deficiency in children with obesity.
Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases (2015)

The infectious agents of the transmissible spongiform encephalopathies are composed of amyloidogenic prion protein, PrPSc. Real-time quaking-induced conversion can amplify very small amounts of PrPSc seeds in tissues/body fluids of patients or animals. Using this in vitro PrP-amyloid amplification assay, we quantitated the seeding activity of affected human brains. End-point assay using serially diluted brain homogenates of sporadic Creutzfeldt-Jakob disease patients demonstrated that 50% seeding dose (SD50) is reached approximately 10(10)/g brain (values varies 10(8.79-10.63)/g). A genetic case (GSS-P102L) yielded a similar level of seeding activity in an autopsy brain sample. The range of PrPSc concentrations in the samples, determined by dot-blot assay, was 0.6-5.4 μg/g brain; therefore, we estimated that 1 SD50 unit was equivalent to 0.06-0.27 fg of PrPSc. The SD50 values of the affected brains dropped more than three orders of magnitude after autoclaving at 121°C. This new method for quantitation of human prion activity provides a new way to reduce the risk of iatrogenic prion transmission.
Development of a Fluorescent Latex Immunoassay for Detection of a Spectinomycin Antibiotic (2004)

There is a need to develop a rapid and sensitive method to detect spectinomycin residues in animal tissues. A latex fluorescent immunoassay was designed using reagents developed for this assay. The spectinomycin antibody was produced in sheep, and the immunoglobulin (IgG) was purified through a Protein G affinity column and was immobilized onto latex particles. Spectinomycin was labeled with 5-([4,6-dichlorotriazin-2-yl]amino)fluorescein (DTAF). The optimum assay conditions consisted of preincubating the latex-IgG with spectinomycin in buffer solutions or in bovine kidney extracts. DTAF-spectinomycin was added and was further incubated. The bound spectinomycin-DTAF/IgG-latex complex was separated by centrifugation at 4000 g for 10 min. The fluorescence signals of the unbound spectinomycin-DTAF in the supernatant were measured at 485/535 nm excitation/emission. The measured signals were directly proportional to the concentration of spectinomycin in the samples, and spectinomycin was detected at 0-100 ppb with minimum detectability of 5 ppb. The mean regression correlation of four trials in buffer was 0.936 when the % bound complex vs spectinomycin concentration was plotted. Analysis of the kidney extract spiked with 0-100 ppb spectinomycin had a regression correlation of 0.959. This assay provides a rapid screening method for low ppb detection of spectinomycin.
The Scientific Basis for the Relations Between Pulsed‐Doppler Transmitral Velocity Patterns and Left Heart Chamber Properties (1992)

This article presents a didactic approach toward understanding the complex relations between transmitral flow patterns and cardiac properties. We start with some observations, obtained noninvasively, from normal and diseased human hearts, and supplement them with noninvasive and invasive observations from the dog laboratory. We then formulate a conceptual approach that is consistent with a physical interpretation of the data, and that enables us to clarify the roles of the active and passive properties of the left atrium and left ventricle. These basic concepts are incorporated into a computational model wherein the properties of the cardiovascular system can be varied to simulate physiological and pathological states of diastolic function to produce normal and abnormal ventricular flow patterns. We present examples of normal hearts, pressure overload hypertrophy, dilated failing hearts, and ventricles with poor compliance but apparently normal flow patterns. Various isolated perturbations of interest were performed in each of these conditions; and finally, we studied the effects on diastolic indices of a systematic variation of the time constant of ventricular relaxation, and of cardiac output. Among the interesting findings are: flow patterns that mimic mitral stenosis can be created by the properties of the ventricle as well as by the properties of the mitral apparatus; the A/E ratio is greater than normal in the dilated ventricle and in the hypertrophied ventricle with slowed relaxation; and in both conditions, the A/E ratio also increases with decreased cardiac output. Thus, changes in stroke volume, whether due to diastolic or to systolic function, will change indices of diastolic function. Finally, in concentric hypertrophy: large increases in atrial contractility are a necessary condition for large A/E ratios; and slowed ventricular relaxation by itself is incapable of producing a slowed deceleration of early filling; incomplete relaxation and myocardial viscoelasticity are also required.
An Optimization-Based Approach for the Calibration of Lookup Tables in Electronic Engine Control (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.