gebhart/patrepeval huggingface dataset:
Globular glial tauopathy Type I presenting with behavioral variant frontotemporal dementia (2020)

Globular glial tauopathy (GGT) is a recently proposed tauopathy characterized by the globular accumulation of four-repeat (4R) tau in the oligodendroglia (globular oligodendroglial inclusion (GOI)) and astrocytes (globular astrocytic inclusion (GAI)), in addition to deposition in neurons. Although it is proposed that GGT should be classified into three different neuropathological subtypes, previous reports have indicated that subclassification might be difficult in some cases. We report an autopy case of a 79-year-old man with behavioral variant frontotemporal dementia (bvFTD). He developed behavioral changes at 67 years of age and had auditory hallucinations and persecutory delusions at admission to a psychiatric hospital at 69 years of age. Neuropathologically, marked atrophy of the frontotemporal lobes and severe degeneration of the white matter and frontopontine tract were observed. The present case corresponded to GGT Type I, as numerous GOIs were observed, predominantly in the frontotemporal region. However, concurrent degeneration of the motor cortex and corticospinal tract suggest characteristics of Type II. Although the relationship between psychotic symptoms and GGT remains unclear, the present case demonstrates heterogeneity of GGT subtypes.
Apple Cultivar Variations in Response to Heat Treatment and Minimal Processing (1993)

ABSTRACT Eleven apple cultivars were subjected to heat treatments at various times and temperatures. Susceptibility to browning during heat treatment and after heat treatment was evaluated. Changes in firmness, respiration rate, soluble solids and acidity of slices prepared with heat treated apples were measured. Incidence of browning was dependent upon cultivar and heating temperature; Liberty, Monroe, RI Greening and Rome were very susceptive, while McIntosh, NY 674 and Empire were less susceptive. Golden Delicious and Delicious showed relative strong tolerance to heat. Apples that received heat treatment at 45°C produced slices with less browning and firmer texture compared to non‐treated apples. The positive effect of heat treatment might help produce high quality minimum processed fruits.
Micro-grid powered by photovoltaic and micro turbine. (2017)

In this paper, we propose to study the possibility of using a photovoltaic system combined with a high speed micro-turbine. This hybrid system can work as stand-alone system or grid connected system as it will be a part of a micro-grid. Initially, we propose simple dynamic models of photovoltaic and micro turbine systems. Then, we carry out a comparison between simulations and measurements of the two systems. At last, simulation results show the effectiveness of the suggested hybrid system.
O2 transfer kinetics in a whole blood unicellular thin layer (1990)

A planar monocellular layer of whole blood (WB) sandwiched between two Gore-Tex membranes is used to study O2 uptake and release kinetics at 37 degrees C. Gore-Tex, a highly gas-permeable open mesh of Teflon fibrils (78% porosity, 0.2-microns pore size, 75-microns thick), constrains WB to form a thin film without imposing an appreciable gas diffusion barrier. WB layer thickness, measured by isotope dilution, is 1.7 +/- 0.2 microns. WB films are mounted between fiber optics in a gas flow tube for dual-wavelength (536/558 nm) oxyhemoglobin saturation measurements after a step change in PO2. For isocapnic (6% CO2) step changes in PO2 between 0 and 104 Torr, WB O2 uptake half time is 10.4 +/- 0.9 ms; WB O2 release half time is 20.6 +/- 2.4 ms. Half-time values are half of those previously reported. The thin-layer method reduces erythrocyte diffusion boundary layer error and thereby offers an attractive alternative to classical rapid fluid-mixing techniques.
Inter-organization cooperative DDoS protection mechanism (2016)

As DDoS attacks evolve rapidly in the aspect of volume and
sophistication, cooperation among operators has become very necessary
because it gives us quicker and more sophisticated protection to cope
with the varius DDoS attacks. This document describes possible
mechanisms which implement the cooperative inter-organization DDoS
protection by DOTS protocol. The described data models are intended to
cover intra-organization and inter-organization solutions.
Traceless Solid-Phase Synthesis of Substituted Benzimidazolones (2004)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTraceless Solid-Phase Synthesis of Substituted BenzimidazolonesChih-Chung Wang and Wen-Ren LiView Author Information Department of Chemistry, National Central University, Chung-Li, Taiwan 32054 Cite this: J. Comb. Chem. 2004, 6, 6, 899–902Publication Date (Web):September 11, 2004Publication History Received2 April 2004Published online11 September 2004Published inissue 1 November 2004https://pubs.acs.org/doi/10.1021/cc049926jhttps://doi.org/10.1021/cc049926jresearch-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views220Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (3)»Supporting Information Supporting Information SUBJECTS:Anions,Organic compounds,Organic polymers,Solid phase synthesis,Solvents Get e-Alerts
Bafilomycin A1 in bone resorption and tooth eruption in dogs (1995)

Tooth eruption depends on bone resorption to form an eruption pathway. We have previously shown that a 2-wk local infusion of bafilomycin A1, an inhibitor of vacuolar H(+)-ATPases in osteoclasts, into the crypts of erupting mandibular premolars in dogs blocks bone resorption during this period and eruption of these teeth is delayed for 8 wk. Here we report the limits of inhibition of resorption that still permit eruption of these teeth. In 3 dogs 10(-6) M bafilomycin was delivered by osmotic minipumps early (18 wk) in eruption to the fourth premolar for 1, 3 or 4 wk. Radiographs taken at weekly intervals thereafter showed that bafilomycin delivery for 1 wk delayed eruption for 3 wk, delivery for 3 wk delayed eruption 9 wk and delivery for 4 wk prevented eruption. These data show that tooth eruption is delayed in direct proportion to the time resorption is blocked, and that this process for dog premolars cannot be blocked for more than 3 wk with 10(-6) M bafilomycin without blocking eruption itself.
Robust Design of Fuzzy Structured Controllers via a Moving Boundaries Process (2014)

In this paper, we consider the design of a fuzzy structured controller for systems that can be well described by uncertain T-S fuzzy models. Finding such a controller is known to be computationally intractable by the conventional techniques. Therefore, to solve this design problem easily and directly, we utilize a moving boundary process together with a robust stability test, for finding a solution to the corresponding feasibility problem. Some design examples are presented to illustrate the main points introduced in this paper.
Determination of the Inorganic Ion Composition of Rat Airway Surface Fluid by Capillary Electrophoresis: Direct Sample Injection To Allow Multiple Analyses from Nanoliter Volumes (1995)

The pulmonary airways are covered by a layer of airway surface fluid (ASF) which is typically < 30 microm in thickness. ASF composition is an important factor in the pathogenesis of several lung diseases including cystic fibrosis. Because of the very small volume of ASF, it is difficult to determine ASF composition, Particularly for inorganic ions, since sampling by lavage is not suitable. With nanoliter injected volumes, capillary electrophoresis (CE) is ideally suited to ASF analysis. We have developed a novel technique using separate sampling and injection capillaries whereby submicroliter volumes of ASF (typically approximately 100 nL) can be collected from airways and then analyzed by CE. Cations (Na+, K+, Ca2+, Mg2+) and anions (including Cl-) are quantitated (RSD < 10%) using indirect UV detection. In healthy rat lungs, ASF was found to be hypotonic, consistent with observations made in human airways. This technique has been developed using rats, which have not previously been studied because their small size prohibits the use of other sampling techniques.
Thermal Decomposition of Zircon Refractories (2001)

Zircon can be used to make refractory brick for the glass industry. At elevated temperatures it is known to dissociate into silica and zirconia. This study was undertaken because one of the factors that can adversely affect the quality of the glass melted in zircon‐lined tanks is the degree of dissociation. The thermal dissociation of purified and unpurified zircon refractory was studied by ambient‐ and high‐temperature X‐ray diffraction (HTXRD) to understand the high‐temperature performance of brick made from this material. Most of the data were collected on powders at or below 1650°C; however, data were collected between 1400° and 2000°C. In addition, small pieces of the refractory were heated to 1650°C, cooled to room temperature, and then examined under ambient conditions. The degree of dissociation was shown to be dependent on purity, particle size, peak temperature, and time at temperature. The HTXRD dissociation was monitored using the intensity of the tetragonal zirconia peaks. The monoclinic polymorph was measured in the ambient runs. High‐temperature mass spectrometry (HTMS) showed that the silica is vaporized at elevated temperatures.
Increased Mucosal IL-12 Expression is Associated with Relapse of Ulcerative Colitis (2021)

Abstract Background: The role of IL-12/23 in the pathogenesis of ulcerative colitis (UC) is unclear. We analyzed mucosal IL-12/23 expression and its relationship with endoscopic severity, histological activity, and UC relapse. Methods: Rectal biopsies were collected from 70 UC patients with clinical remission. IL-12, IL-23, IFN-g, IL-17A, and IL-17F mRNA expression was measured by real-time PCR. Endoscopic severity and histological activity were evaluated using the Mayo endoscopic subscore (MES) and the Geboes score, respectively. Results: The longest follow-up period was 51 months. Thirty-four patients relapsed during the study period. Samples from these subsequently relapsed patients formed the “relapse” group, while those from patients that did not relapse formed the “remission” group. IL-12 ( P =0.0003) and IL-23 ( P =0.014) mRNA expression was significantly higher in the relapse than the remission group. Expression of IL-23 ( P =0.015) but not IL-12 ( P =0.374) was correlated with MES. However, in patients with an MES of 0 and 1, IL-12 expression was statistically higher in the relapse than the remission group ( P =0.0015, P =0.0342). IL-12 and IL-23 expression did not vary significantly between histologically active and inactive mucosa; both were higher in histologically inactive patients in the remission group (IL-12: P =0.0002, IL-23: P =0.046). Conclusions: Rectal IL-12 and IL-23 expression was elevated in the relapse group, but IL-12 was more strongly associated with UC relapse, irrespective of endoscopic severity and histological activity. Mucosal IL-12 was elevated in patients with deep mucosal healing. Our results suggest an important role of IL-12 in UC pathogenesis and the molecular mechanism of UC relapse.
The Fiduciary Duties of the Crown to Maori: Will the Canadian Remedy Travel? (2005)

The article identifies and examines the various features of the equitable remedy developed in Canada, under which the Crown is held liable to indigenous peoples for acts and omissions in breach of a fiduciary duty. It argues that the Canadian remedy and the ideas on which it is based are largely applicable in the context of New Zealand law. It also evaluates the elements of the Crown/Maori relationship under which the remedy could be used and examines how lapse of time impacts the availability of the remedy.
Final feasibility - environmental and resettlement impact assessment (2000)

While the Road Sector Institutional Support Technical Assistance Project will examine rehabilitation options to minimize the need for ongoing road maintenance, the environmental assessment considers the potential environmental effects of the project on social, cultural, and economic resources, in a two-volume report covering the Katunguru - Kasese - Fort Portal Road, and Kasese - Kilembe Road - Equator Road segments. Measures to mitigate adversity are: To reduce the effects of road widening, those works within road reserves, should be conducted after harvest period, and, for those outside road reserve, compensation should be granted to affected landowners. As a result of earthworks, borrow pits will be available for waste, and spoil disposal, in an effort to reduce hydrological damage. Noise, dust, and safety risks will be minimized by limiting working hours to daytime schedules, enforcing control measures to reduce traffic speed, and, securing access to pedestrians, and cyclists through adequate traffic signals, and temporary diversions. During construction, health facilities will be available on-site, to ensure the well-being of local workforce, and communities. Maintenance of drainage infrastructure will be pursued, to avoid potential flooding of adjacent properties.
High‐dose therapy and autologous stem cell transplantation for children with HIV‐associated non‐Hodgkin lymphoma (2006)

In contrast to adults, autologous stem cell transplantation (ASCT) as part of the salvage strategy after high-dose chemo/radiotherapy in human immunodeficiency virus (HIV) related Non-Hodgkin lymphoma (NHL) is not yet established for children. We report on a 13-year patient with congenital HIV infection and refractory Burkitt lymphoma, who was successfully treated by high-dose therapy (HDT) including rituximab followed by ASCT. After 26 months follow-up the patient remains in complete remission and his HIV parameters have normalized with continued highly active antiretroviral therapy (HAART). HIV infection may no longer exclude children from ASCT as part of salvage therapy.
Adaptive immunity to murine skin commensals (2014)

The adaptive immune system provides critical defense against pathogenic bacteria. Commensal bacteria have begun to receive much attention in recent years, especially in the gut where there is growing evidence of complex interactions with the adaptive immune system. In the present study, we observed that commensal skin bacteria are recognized by major populations of T cells in skin-draining lymph nodes of mice. Recombination activating gene 1 (Rag1)(-/-) mice, which lack adaptive immune cells, contained living skin-derived bacteria and bacterial sequences, especially mycobacteria, in their skin-draining lymph nodes. T cells from skin-draining lymph nodes of normal mice were shown, in vitro, to specifically recognize bacteria of several species that were grown from Rag1(-/-) lymph nodes. T cells from skin-draining lymph nodes, transferred into Rag1(-/-) mice proliferated in skin-draining lymph nodes, expressed a restricted T-cell receptor spectrotype and produced cytokines. Transfer of T cells into Rag1(-/-) mice had the effect of reducing bacterial sequences in skin-draining lymph nodes and in skin itself. Antibacterial effects of transferred T cells were dependent on IFNγ and IL-17A. These studies suggest a previously unrecognized role for T cells in controlling skin commensal bacteria and provide a mechanism to account for cutaneous infections and mycobacterial infections in T-cell-deficient patients.
Abstract ND09: The discovery and characterization of CFT8634: A potent and selective degrader of BRD9 for the treatment of SMARCB1-perturbed cancers (2022)

Abstract Introduction: The chromatin factor BRD9 is a genetic dependency in some cancers, often referred to as SMARCB1-perturbed cancers. Two types of genetic alterations result in SMARCB1 perturbation: SS18-SSX gene fusion and SMARCB1 loss-of-function mutations. In synovial sarcoma, a rare and aggressive soft tissue malignancy comprising approximately 10% of all soft tissue sarcomas, the presence of the SS18-SSX fusion gene drives the disruption of SMARCB1 function and leads to a synthetic lethal dependence on BRD9. In SMARCB1-null solid tumors, for example malignant rhabdoid tumors (MRT), poorly differentiated chordomas, and epithelioid sarcomas, the absence of SMARCB1 protein results in a similar BRD9 dependence. Thus, in SMARCB1-perturbed cancers, including synovial sarcoma and SMARCB1-null cancers, degradation of BRD9 is hypothesized to result in an anticancer effect. CFT8634 is an orally bioavailable heterobifunctional degrader that induces ternary complex formation with BRD9 and an E3 ligase, leading to the ubiquitination of BRD9 and its subsequent degradation by the proteasome. Results: Here we describe the chemical structure of CFT8634 and an overview of the medicinal chemistry path leading to its discovery. In vitro, CFT8634 promotes rapid, potent, deep, and selective degradation of BRD9 with a half-maximal degradation concentration (DC50) of 2 nM in a synovial sarcoma cell line. In long-term growth assays, CFT8634 is effective at impairing cell growth in a concentration-dependent manner specifically in SMARCB1-perturbed contexts. In vivo, oral dosing of CFT8634 in xenograft models of SMARCB1-perturbed cancers leads to robust and dose-dependent degradation of BRD9, which translates to significant and dose-dependent inhibition of tumor growth in preclinical xenograft models. Conclusion: The preclinical data presented herein support the clinical development of CFT8634 for the treatment of synovial sarcoma and SMARCB1-null tumors. Citation Format: Katrina L. Jackson, Roman V. Agafonov, Mark W. Carlson, Prasoon Chaturvedi, David Cocozziello, Kyle Cole, Richard Deibler, Scott J. Eron, Andrew Good, Ashley A. Hart, Minsheng He, Christina S. Henderson, Hongwei Huang, Marta Isasa, R. Jason Kirby, Linda Lee, Michelle Mahler, Moses Moustakim, Christopher G. Nasveschuk, Michael Palmer, Laura L. Poling, Roy M. Pollock, Matthew Schnaderbeck, Stan Spence, Gesine K. Veits, Jeremy L. Yap, Ning Yin, Rhamy Zeid, Adam S. Crystal, Andrew J. Phillips, Stewart L. Fisher. The discovery and characterization of CFT8634: A potent and selective degrader of BRD9 for the treatment of SMARCB1-perturbed cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr ND09.
P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer. (1993)

Activated platelets and stimulated endothelial cells express P-selectin, an integral membrane protein receptor that binds monocytes and neutrophils. P-selectin mediates adhesion to glycoproteins with carbohydrate structures containing sialyl-Lewis X. Since many carcinoma cells also express these carbohydrate structures and are known to interact with platelets, we asked whether P-selectin may mediate this interaction. Both small cell lung cancer and neuroblastoma cell lines bound to activated platelets, and this interaction was blocked with inhibitory anti-P-selectin antibodies and by pretreatment of these cancer cells with neuraminidase or trypsin. Platelet binding to the small cell lung cancer cells was not inhibited with anti-GP IIb-IIIa antibody or Arg-Gly-Asp-Ser peptide. Pretreatment of the neuroblastoma cells with inhibitors of N-linked carbohydrate biosynthesis had little effect on binding to P-selectin, indicating that relevant carbohydrate ligand(s) may be O-linked. In addition, lipospheres containing P-selectin specifically bound to cryostat sections derived from a small cell lung tumor and two neuroblastoma tumors, but not to sections of normal lung. These observations demonstrate that P-selectin mediates binding of platelets to small cell lung cancer and to neuroblastoma and suggest a possible role for this lectin in metastasis.
Basement membrane proteins in the space of Disse: a reappraisal. (1991)

The distribution of two major basement membrane components, type IV collagen and laminin, was studied within the perisinusoidal space of Disse in normal human liver using (i) an immunoperoxidase method for light microscopy and (ii) immunogold labelling for ultrastructural localisation. Although immunoreactivity depended on the mode of tissue fixation, both proteins could be identified at this site using a panel of affinity purified antibodies. These findings indicate that these proteins are normal constituents of the perisinusoidal extracellular matrix, and refute the hypothesis that capillarization of the sinusoids in chronic liver disease results from neo-expression of laminin in the space of Disse.
Left ventricular aneurysms: pathophysiologic observations and standard resection. (1997)

For the past four decades, the standard approach to the treatment of left ventricular aneurysms has been to resect the aneurysm wall and close it in a linear fashion. During the past decade, evidence has accumulated that this simple approach may not be the most efficacious in terms of either short-term ventricular function or long-term survival and quality of life. To establish the basis against which the newer techniques are to be compared, this article describe the historical evolution of procedures designed to treat ventricular aneurysms, the pathophysiolgy of aneurysms, the standard surgical technique still used by most surgeons, and the rationale for the newer surgical approaches.
Effect of Hydrated Metal Salts on the Coordination Product of Cobalt(II) halide and PNP Type Ligand, 2,6-bis(di-tertbutylphosphinomethyl) pyridine (2018)

Chemical treatment of CoX2. 6H2O (X = Cl, Br, I) with the potentially tridentate PNP pincer ligand 2,6-bis(di-tert-butylphosphinomethyl)pyridine in 1:1 molar ratio results in cobalt(II) halide-PNP pincer complexes. The effect of the hydrated metal source on molecular structure and geometry of the complexes was studied by single crystal X-ray diffraction analysis. The complexes are neutral and the cobalt center adopts a penta-coordinate system with potential atropisomerization. Within the unit cell there are two distinct molecules per asymmetric unit. One of the two phosphorus atoms in the PNP ligand was observed to be partially oxidized to phosphinoxide. Disorder in the structure reflects a mixture of square pyramidal and distorted tetrahedral geometry.
Pollen-Pistil Interactions and Their Role in Mate Selection (2016)

Pollen-pistil interactions contribute to mate selection at the postmating, prezygotic level.