gebhart/patrepeval huggingface dataset:
How to make a 350-m-thick lowstand systems tract in 17,000 years: The Late Pleistocene Po River (Italy) lowstand wedge (2017)

Abstract The 350-m-thick succession of the Po River lowstand wedge (Italy) associated with the Last Glacial Maximum (deposited over ∼17 k.y) contains stratal architecture at a physical scale commonly attributed to much longer time scales, with complex, systematically varying internal clinothem characteristics. This study investigated clinothem stacking patterns and controls through the integration of seismic reflection data with sediment attributes, micropaleontology, regional climate, eustacy, and high-resolution age control possible only in Quaternary sequences. Three clinothem types are differentiated based on topset geometry, shelf-edge and onlap-point trajectory, internal seismic facies, and interpreted bottomset deposits: type A has moderate topset aggradation, ascending shelf-edge trajectory, and mass-transport bottomset deposits; type B has eroded topset, descending shelf-edge trajectory, and bottomset distributary channel-lobe complexes; and type C has maximal topset aggradation, ascending shelf-edge trajectory, and concordant bottomsets. Type A and C clinothems exhibit reduced sediment bypass and delivery to the basin, whereas type B clinothems are associated with short intervals of increased sediment export from the shelf to deeper water. Clinothems individually span a range of 0.4–4.7 k.y., contemporaneous with significant eustatic and climate changes, but their stacking patterns resemble those found in ancient successions and ascribed to significantly longer durations, indicating that (1) the response time of ancient continental margin–scale systems to high-frequency variations in accommodation and sediment supply could be as short as centuries, (2) even millennial- to centennial-scale stratal units can record substantial influence of allogenic controls, and (3) sandy deposits can be compartmentalized even in a short-duration lowstand systems tract.
An Ego-Vision System for Hand Grasp Analysis (2017)

This paper presents an egocentric vision (ego-vision) system for hand grasp analysis in unstructured environments. Our goal is to automatically recognize hand grasp types and to discover the visual structures of hand grasps using a wearable camera. In the proposed system, free hand–object interactions are recorded from a first-person viewing perspective. State-of-the-art computer vision techniques are used to detect hands and extract hand-based features. A new feature representation that incorporates hand tracking information is also proposed. Then, grasp classifiers are trained to discriminate among different grasp types from a predefined grasp taxonomy. Based on the trained grasp classifiers, visual structures of hand grasps are learned using an iterative grasp clustering method. In experiments, grasp recognition performance in both laboratory and real-world scenarios is evaluated. The best classification accuracy our system achieves is $\text{92}\%$ and $\text{59}\%$ , respectively. System generality to different tasks and users is also verified by the experiments. Analysis in a real-world scenario shows that it is possible to automatically learn intuitive visual grasp structures that are consistent with expert-designed grasp taxonomies.
Microcapsules based on glycinin–sodium dodecyl sulfate complex coacervation (2004)

Microcapsules processed by complex coacervation were prepared using hexadecane for the oil phase and glycinin (a soybean storage protein)-sodium dodecyl sulfate (SDS) as the main wall-forming material. The study underlines the essential role of SDS, which, by the way of [glycinin(+)-SDS(-)] insoluble complex formation, allowed the precipitation of proteins around oil droplets. Moreover, particular attention was attributed to the study of suitable conditions of glycinin cross-linking with glutaraldehyde. The reticulation step was performed at pH 4.0 and it was observed that the precipitated state of proteins increased considerably the efficiency of the cross-linking reaction. Analysis of the reactional medium after each main step of the process (emulsification, complex coacervation, cross-linking) allowed the follow-up and characterization of microcapsule formation. Optimization of different process parameters such as glycinin concentration, glycinin/SDS/glutaraldehyde ratios, pH and the kinetics of cross-linking allowed the encapsulation of the totality of oil and the use of more than 98% of initially introduced proteins for the microcapsule wall formation.
Fatty Acid Composition of Hydrocarbon-Assimilating Yeast (1966)

As a part of extensive program on microbial utilization of hydrocarbons, lipid components of Candida petrophillum SD-14 grown on n-alkanes and glucose as carbon sources were studied. In any carbon source, cellular fatty acids of the yeast contained palmitic, palmitoleic, stearic, oleic and linoleic acids as major components. When n-tridecane was fed to the yeast, fatty acids with odd- and even-number of carbon atoms were produced in almost identical quantity. Another yeast, Torulopsis petrophillum SD-77, also gave a very similar fatty acid pattern by n-tridecane substrate. These phenomena indicate the existence of C2 addition and β-oxidation of the fatty acid formed in the yeasts. In the cases of n-tridecane, n-hexadecane and glucose as substrate, about a half of SD-14’s lipid was phospholipid, which consisted of phosphatidyl ethanolamine and phosphatidyl choline principally. Free alcohol and wax were not detected in any case.
Development of an environmentally-durable, low-friction coating (2021)

Abstract In this communication, we highlight the development of a new coating that offers environmental durability and low-friction characteristics by exploiting the low interfacial bond strength of fillers with lamellar structures. The water-based coating has low volatile organic compound (VOC) content (&lt; 50 g/L), offers the ability to be pigmented, demonstrates resilience against accelerated aging exposures, and exhibits even lower friction with extended weathering. The low-friction coating provides a simple method for modifying surface properties, and has the potential to complement Jersey walls by inhibiting vertical climb and thus decreasing the probability of vehicular roll-over upon impact. Graphic Abstract
A T-cell–redirecting bispecific G-protein–coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma (2020)

T-cell-mediated approaches have shown promise in myeloma treatment. However, there are currently a limited number of specific myeloma antigens that can be targeted, and multiple myeloma (MM) remains an incurable disease. G-protein-coupled receptor class 5 member D (GPRC5D) is expressed in MM and smoldering MM patient plasma cells. Here, we demonstrate that GPRC5D protein is present on the surface of MM cells and describe JNJ-64407564, a GPRC5DxCD3 bispecific antibody that recruits CD3+ T cells to GPRC5D+ MM cells and induces killing of GPRC5D+ cells. In vitro, JNJ-64407564 induced specific cytotoxicity of GPRC5D+ cells with concomitant T-cell activation and also killed plasma cells in MM patient samples ex vivo. JNJ-64407564 can recruit T cells and induce tumor regression in GPRC5D+ MM murine models, which coincide with T-cell infiltration at the tumor site. This antibody is also able to induce cytotoxicity of patient primary MM cells from bone marrow, which is the natural site of this disease. GPRC5D is a promising surface antigen for MM immunotherapy, and JNJ-64407564 is currently being evaluated in a phase 1 clinical trial in patients with relapsed or refractory MM (NCT03399799).
Steroidogenesis-Inducing Protein, Isolated from Human Ovarian Follicular Fluid, Is a Potent Mitogen for Cell Lines Derived from Ovarian Surface Epithelial Carcinomas (1997)

The majority of human ovarian cancers originate from the surface epithelial (OSE) cells that surround the ovary. The incidence of OSE cancer is correlated with the number of ovulations that occur during fertile life. OSE cells remain quiescent but undergo rapid mitotic activity after ovulation to repair the wound. This increase in mitotic activity following each ovulation may give rise to mutations that make the OSE susceptible to malignant transformation. Steroidogenesis-inducing protein (SIP), a protein isolated from human follicular fluid obtained from hyperstimulated ovaries, is a potent mitogen for several gonadal cells. To investigate the possibility that SIP may be involved in the proliferation of OSE cells, we have studied its effects on DNA synthesis in seven cell lines derived from OSE carcinomas (HEY, MLS, SKA, OW-1, SAU, NIH:OVCAR-3, and Caov-3). The cells were cultured in serum-free medium in the presence of SIP for 18 hr, followed by incubation with [3H]thymidine for 4 hr. The radioactivity incorporated into the DNA was measured. SIP stimulated DNA synthesis in six of the cell lines. HEY, SKA, MLS, and OVCAR3 were most responsive to SIP. Interactions between SIP and other growth factors and cytokines known to be present in follicular fluid (EGF/TGFalpha, TGFbeta, FGF, IGF-1, IL-1beta, and TNFalpha) were also investigated in HEY and SKA cells. EGF/TGFalpha and IGF-1 potentiated the effects of SIP. TGFbeta had no effect on SIP, and/or EGF/TGFalpha stimulated DNA synthesis. Other growth factors which were tested in this study had no effect on DNA synthesis in SKA cells. Dibutyryl cyclic-AMP blocked the effects of SIP on DNA synthesis. We conclude that SIP is a potent mitogen for OSE cell lines and together with TGFalpha and IGF-1 may be involved in the proliferation of normal OSE cells after ovulation. Since SIP is obtained from the preovulatory follicle, it may represent a link between the number of ovulations and the increased incidence of OSE cancers.
Valve prosthesis hemodynamics and the problem of high transprosthetic pressure gradients (1992)

Recent studies suggest that all prosthetic valves are at least mildly stenotic and may cause relatively high pressure gradients despite normal prosthesis function; such gradients could be due to a mismatch between prosthesis effective orifice area and patient's body size. In order to address this problem more directly, we derived, using a physiologic pulse duplicator system, the theoretical relations between transprosthetic pressure gradients and prosthesis effective orifice areas indexed for body surface area, assuming a normal resting cardiac index of 3.0 l/min m-2 and 10-50% increases in stroke volume such as may occur during maximal upright exercise. These exponential relations show that a small decrease in indexed effective orifice area produces a large increase in pressure gradient, and that the indexed effective orifice area should ideally be not less than 0.9-1.0 cm2/m2 for aortic prostheses and 1.3-1.5 cm2/m2 for mitral prostheses in order to minimize postoperative gradients. Thus, high postoperative gradients do not necessarily indicate intrinsic prosthesis dysfunction but may also be due to patient prosthesis mismatch. Intrinsic prosthetic performance is best assessed by comparing in vivo calculated effective orifice areas to in vitro measurements for same type and size of prosthesis. Patient prosthesis mismatch can be avoided by calculating before operation the projected indexed effective orifice area of the prosthesis being implanted.
Elevated atmospheric sulfur levels off the Peruvian coast (1986)

Elevated levels of non‐sea‐salt sulfate and SO 2 in samples collected off the west coast of South America indicate that there is a major source of atmospheric sulfur in the region of southern Peru and northern Chile. During a 1983 cruise, observed concentrations of non‐sea‐salt sulfur, SO 2 , selenium, arsenic, and antimony were comparable to levels reported for moderately polluted urban air. In contrast, methanesulfonic acid levels were typical of coastal marine air. Clearly, the elevated atmospheric sulfur levels in this region cannot be ascribed to oceanic organosulfur emissions. The major inputs are tentatively attributed to the smelting of sulfide ores which is a major industry in this region. The transport of smelter derived aerosols to this region may have a number of consequences for the atmospheric and oceanic chemistry of the Peruvian upwelling area.
Correction: Amino acids regulate mTORC1 by an obligate two-step mechanism. (2020)

In the originally published Fig. The mistake was caused by confusion over file names during creation of the figure. This error has now been corrected. The bar graphs in the original Fig. 1, B and C, are based on quantitation of multiple blots and are correct as shown. This correction does not affect the results or conclusions of this work.
Large-Scale 13 C Flux Profiling Reveals Conservation of the Entner-Doudoroff Pathway as a Glycolytic Strategy among Marine Bacteria That Use Glucose (2015)

ABSTRACT Marine bacteria form one of the largest living surfaces on Earth, and their metabolic activity is of fundamental importance for global nutrient cycling. Here, we explored the largely unknown intracellular pathways in 25 microbes representing different classes of marine bacteria that use glucose: Alphaproteobacteria , Gammaproteobacteria , and Flavobacteriia of the Bacteriodetes phylum. We used 13 C isotope experiments to infer metabolic fluxes through their carbon core pathways. Notably, 90% of all strains studied use the Entner-Doudoroff (ED) pathway for glucose catabolism, whereas only 10% rely on the Embden-Meyerhof-Parnas (EMP) pathway. This result differed dramatically from the terrestrial model strains studied, which preferentially used the EMP pathway yielding high levels of ATP. Strains using the ED pathway exhibited a more robust resistance against the oxidative stress typically found in this environment. An important feature contributing to the preferential use of the ED pathway in the oceans could therefore be enhanced supply of NADPH through this pathway. The marine bacteria studied did not specifically rely on a distinct anaplerotic route, but the carboxylation of phosphoenolpyruvate (PEP) or pyruvate for fueling of the tricarboxylic acid (TCA) cycle was evenly distributed. The marine isolates studied belong to clades that dominate the uptake of glucose, a major carbon source for bacteria in seawater. Therefore, the ED pathway may play a significant role in the cycling of mono- and polysaccharides by bacterial communities in marine ecosystems.
Measurements of crystal growth kinetics at extreme deviations from equilibrium. [Rapid solidification processing] (1993)

We have measured solute trapping of Sn in Al over a wide enough range of velocities to make a quantitative test of theory. The Continuous Growth Model of Aziz is the only one-parameter model that fits the data. We have also measured the diffusive speed - the growth rate at which interfacial partitioning is in mid-transition between equilibrium partitioning and complete solute trapping - for several solutes in A1. We have found an inverse correlation between the equilibrium partition coefficient and the diffusive speed. Taken together, these results give us heretofore unprecedented predictive capability in modeling rapid solidification processing. We have also examined theoretically short-range diffusion-limited growth, characteristic of incomplete solute trapping, and interface-limited growth, characteristic of complete solute trapping, in alloy solidification and have shown that the two regimes fall naturally out of a single unified theory of solidification.
Menopausia, isoflavonas, equol y poblaciones microbianas intestinales (2014)

Trabajo presentado en el V Workshop Probióticos, Prebióticos y Salud: Evidencia Científica, celebrado en Valencia el 23 y 24 de enero de 2014.
Antibody Responses to Cancer Antigens Identify Patients with a Poor Prognosis among HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma Patients (2019)

We identified antibody responses to cancer antigens that associate with a dismal prognosis in patients with HNSCC beyond HPV-positive status. AR<sub>high risk</sub> may be used to detect HPV-negative patients with an extraordinarily bad prognosis. Most importantly, antibody response to IMP-1 may serve as a marker for a subgroup of HPV-positive patients who present with a poor prognosis similar to that in HPV-negative patients.
Practical Methods for Tissue Microarray Construction (2004)

The tissue microarray (TMA) of Kononen et al. is an extension of an idea originally developed by Battifora and consists of an array of cylindrical cores of paraffin-embedded tissue that are removed from preexisting "donor" paraffin blocks. The donor block is a standard tissue block that may be from surgical pathology, autopsy, or research material. A morphologically representative area of interest within the donor block is identified under the microscope using a stained section (usually hematoxylin and eosin stained) on a glass slide as a guide. The tissue cores are removed from the donor and inserted into a "recipient" paraffin block usually using a custom patented instrument from Beecher Instruments. Using a precise spacing pattern, tissues are inserted at high density, with up to 1000 tissue cores in a single paraffin block. Sections from this block that are cut with a microtome are placed onto standard slides that can then be used for in situ analysis. Depending on the overall depth of tissue remaining in the donor blocks, tissue arrays can generate between 100 and 500 sections. Once constructed tissue microarrays can be used with a wide range of techniques including histochemical staining, immunohistochemical/immunofluorescent staining, or in situ hybridization for either DNA or mRNA. In this chapter we present methods of TMA construction with emphasis on providing detailed tips and techniques.
Defect Structure of Heteroepitaxial SnO2 Thin Films Grown on TiO2 Substrates (2001)

Heteroepitaxal SnO 2 thin films were grown on rutile (100) TiO 2 single crystal substrates by pulsed laser deposition. The defect structure and surface morphology were investigated by transmission electron microscopy, reflection high-energy electron diffraction, and atomic force microscopy. The misfit-induced large biaxial compressive stress in the 200-nm-thick SnO 2 thin film was almost fully relaxed to yield the high-density interfacial misfit dislocations and related planar defects. The misfit dislocation network on the hetero-interface consisted of two types of partial edge dislocations with Burgers vectors of 1/2&lt;101&gt; and 1/2&lt;110&gt;, which involved {101} and {010} planar defects formed in the film, respectively. The evolution of the surface morphology and cross-sectional structure for thinner films suggested that the introduction of such defects occurs at the early growth stage, due to large lattice misfit, and is strongly affected by point defect condensation.
Performance of Horizontal Injection–Horizontal Production Wells in a Five Spot Pattern: Experimental Approach (2009)

Abstract This article presents an experimental investigation to study the effect of horizontal injector well length on oil recovery in a five spot water flood pattern having arrays of horizontal wells. The results of this study show that breakthrough recovery increases as the length of the horizontal injection well increases. However, recoveries at 95% water cut were found to be almost the same for all the injection well lengths investigated. It is also found that the additional recoveries after water breakthrough decreases as the length of the horizontal injection well increases. This is associated with sharp increase in % water cut after breakthrough. Keywords: Performance of horizontal injectors/producerswater flooding using horizontal injection wells ACKNOWLEDGEMENTS The author gratefully acknowledges the support of the Petroleum Engineering Department at King Fahd University of Petroleum & Minerals for allowing him to use their laboratory facilities and for providing the manpower for conducting the experiments. The author also extends his thanks to Mr. Mousa Ali for conducting the experiments.
Präoperativer transjugulärer intrahepatischer portosystemischer Shunt reduziert das Auftreten von postoperativem Akut-auf-chronische Leberversagen bei Patienten mit hohem CLIF-C AD score (2021)

Einleitung Das Akut-auf-chronische Leberversagen (ACLF) ist ein Syndrom mit Organversagen und hoher Mortalität. Chirurgische Eingriffe wurden als auslösender Faktor für die Entwicklung von ACLF beschrieben. Der Einfluss eines präoperativ bestehenden TIPS auf die postoperative ACLF-Entwicklung bei Patienten mit Leberzirrhose ist noch nicht untersucht und Ziel dieser Studie.
Unsteady heat transfer characteristics in a semitransparent medium heated by diffuse and collimated radiation. (1985)

Solar radiation energy incident to the surface of the earth consists of two components: collimated radiation characterized as direct-beam, and diffuse radiation resulting from multi-scattering of dust, aero-
An enzyme immunoassay for the simultaneous determination of active type-1 plasminogen activator inhibitor (PAI-1), and t-PA/PAI-1 complexes (1995)

An assay has been developed which enables the simultaneous determination of active free PAI-1 and t-PA/PAI-1 complexes in plasma samples. Test plasma is divided into two subsamples in which (a) active PAI-1 is quantitatively converted to t-PA/PAI-1 complexes, and (b) conversion of PAI-1 to t-PA/PAI-1 complexes is prevented. The amounts of t-PA/PAI-1 complex in the two subsamples are then assessed in a one-step enzyme immunoassay (EIA) consisting of a monoclonal anti-PA antibody, and a HRP conjugate of polyclonal anti-PAI-1 antibodies. The amounts of t-PA/PAI-1 complexes in the two subsamples are the t-PA/PAI-1 complex concentrations at the time of sampling (b); whereas the difference between the two values (a)-(b) equals the amount of active PAI-1. The assay has a high sensitivity, specificity, accuracy and precision. The time-to-result is 4.5 h. It meets the criteria set by the Scientific and Standardization Committee (SSC) of the International Society of Thrombosis and Haemostasis (ISTH) for a candidate reference method.
Investigation of a full duplex acoustic link for a tetherless micro-ROV (2011)

Over the last decade, vast improvements have been made in overcoming Inter Symbol Interference (ISI) in a dynamic underwater channel, with recent work focussing on multi-carrier systems due to their inherent multipath tolerance. However, the practical implementation of a bi-directional link for a micro remotely operated vehicle (ROV) presents additional complications. Erratic acceleration poses a challenge to previously reported Doppler compensation techniques, thus improvements in estimation and tracking are required. The use of a single-carrier scheme is demonstrated and critically evaluated in the presence of severe Doppler and interference caused by the vehicle. Through the tuning of an adaptive closed loop Doppler compensation structure, single-carrier modulation schemes demonstrate reliable high data rate communications. Minimum latency is essential for precise control and simultaneous video transmission, which can be achieved through the use of an asymmetric full duplex link. In this paper, filtering techniques are demonstrated to enable isolation of frequency multiplexed data streams and to prevent saturation of receiver circuitry. Results are presented demonstrating both single-carrier and multi-carrier high data rate transmissions (>;30kbps) simultaneously with low data rate (<;100bps) control signals at distances of over 300m.