gebhart/patrepeval huggingface dataset:
Modified target and concatenated coding for d=1 constrained magnetic recording channels (2002)

A modified E3PRML (ME3PRML) channel with concatenated coding is proposed for d=1 coded magnetic recording channels. First an analytical approach to obtain the optimized target is detailed, and compared with that obtained by search. It is observed that the channel is dominated by single bit error events. A concatenated code with interleaving in conjunction with the 2/3 (1,7) code, and a low-complexity correction method are proposed to detect and correct the dominant error events. For a code rate of 300/459 with 6-way interleaving, the proposed channel provides an improvement of 1.5 dB (including code rate loss) over conventional d=1 E3PRML channel at a bit-error rate of 1E-5, and better robustness to non-linearities than d=0 ME2PRML channel.
Broccoli: Semantic Full-Text Search at your Fingertips (2012)

We present Broccoli, a fast and easy-to-use search engine for what we call semantic full-text search. Semantic full-text search combines the capabilities of standard full-text search and ontology search. The search operates on four kinds of objects: ordinary words (e.g., edible), classes (e.g., plants), instances (e.g., Broccoli), and relations (e.g., occurs-with or native-to). Queries are trees, where nodes are arbitrary bags of these objects, and arcs are relations. The user interface guides the user in incrementally constructing such trees by instant (search-as-you-type) suggestions of words, classes, instances, or relations that lead to good hits. Both standard full-text search and pure ontology search are included as special cases. In this paper, we describe the query language of Broccoli, the main idea behind a new kind of index that enables fast processing of queries from that language as well as fast query suggestion, the natural language processing required, and the user interface. We evaluated query times and result quality on the full version of the English Wikipedia (40 GB XML dump) combined with the YAGO ontology (26 million facts). We have implemented a fully functional prototype based on our ideas and provide a web application to reproduce our quality experiments. Both are accessible via http://broccoli.informatik.uni-freiburg.de/repro-corr/ .
Photo-Voltage Transients for Real-Time Analysis of the Interactions between Molecules and Membranes (2020)

The interfacial dynamic interactions between molecules and cell membranes are critical in many basic biological processes. An effective method for sensitive, real-time, and noninvasive monitoring of these processes is needed. Here, using photoelectric responses of a silicon wafer, the charge–discharge processes of a phospholipid membrane are recorded as voltage transients, which directly reflect the instant structure and properties of the membrane. Based on the time evolution of the as-calculated charge relaxation time constant, dynamic changes in the membrane structure under molecular actions can be analyzed. The swelling and Tween 20 action processes on both mono- and multilayered membranes were taken as examples, which showed more mechanism details in comparison to the traditional X-ray diffraction or fluorescence imaging tests. Our method provides a promising solution for label-free, noninvasive, and real-time studies on the dynamic interactions between molecules and a membrane.
Supplementary Figure 2 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer (2023)

&lt;p&gt;Co-culture with PBNs does not impact on growth of CRC cell lines. (A) PBNs from healthy donors (HD) were co-cultured with 6 different CRC cell lines at a CRC: PBN ratio 1: 20, as described in â€œmaterials and methodsâ€�. After 72h, tumour cells proliferation was measured by 3Hthymidine incorporation. Similar experiments, using LS180 as target cells were also performed by utilizing PBN from patients with CRC (B) and PBN from HD, untreated or following one hour treatment with IFN-Î³ (1ng/ml), fMLP (50Î¼M) or both (C).&lt;/p&gt;
Noise Stimuli (Aci Experiment) (2014)

Noise stimuli involved in the Auditory Classification Image experiment (gaussian noise). 10.000 stimuli for each participant. wav format, 48 kHz
RTOG 0436: A phase III trial evaluating the addition of cetuximab to paclitaxel, cisplatin, and radiation for patients with esophageal cancer treated without surgery. (2014)

4007 Background: RTOG 0436 is a randomized Ph III trial evaluating cetuximab added to concurrent chemoradiation for patients (pts) undergoing non-operative management of esophageal carcinoma (EC). Methods: Pts with biopsy proven squamous cell or adenocarcinoma of the esophagus (T1N1M0; T2-4 AnyN M0; Any T/N M1a) were randomized to weekly concurrent cisplatin (50 mg/m2), paclitaxel (25 mg/m2) for 6 weeks and daily radiation 50.4 Gy/1.8 Gy fractions ± weekly cetuximab (400 mg/m2 day 1 then weekly 250 mg/m2) for 6 weeks. Pts were stratified by histology, tumor size (< 5 cm vs > 5cm) and the status of celiac lymph nodal involvement. Overall survival (OS) was the primary endpoint, with a planned accrual of 420 pts to detect an increase in 2-year OS from 41% to 53%; 80% power and 1-sided 0.025 alpha. An interim analysis of cCR was planned for the first 150 of each histology. Results: The study accrued 344 pts from 2008-2013 and 328 were eligible. Based on interim analyses, the study stopped accruing adeno pts in 5/2012 and SCC pts in 1/2013. Pts were well matched for pretreatment characteristics: 80% T3/4 disease, 66% N1, and 19% celiac nodes. Grade 3/4/5 treatment (tx) related AEs were 45%, 22%, 4% in Arm 1 (cetuximab) and 49%, 17%, 1% in Arm 2 (no cetuximab). A cCR rate of 56% was observed in Arm 1 vs 59% in Arm 2 [p=0.72]. No differences were seen in cCR between tx arms for either histology. The 12 and 24 mo OS rates for cCR pts were 79% and 58% vs 53% and 30% for those with residual disease [p<0.0001]. Median follow-up for all pts is 15.4 mos. The 12 and 24 mo OS (95% CI) for Arm 1 is 64% (56%, 71%) and 44% (36%, 52%) vs 65% (57%, 72%) and 42% (34%, 50%) for Arm 2 [p=0.70]. Adeno pts (n=203) had a 12 and 24 mo OS of 65% and 43% for Arm 1 vs 64% and 41% for Arm 2 [p=0.37]. The 12 and 24 mo OS for the 125 SCC pts was 62% and 46% for Arm 1 vs 67% and 43% for Arm 2 [p=0.97]. Conclusions: Cetuximab added to chemoradiation did not improve OS. There were no differences in cCR rates by tx arm. These results add to the growing body of literature indicating no benefit for current EGFR targeted agents in the tx of unselected patients with EC. Supported by RTOG CA21661 and CCOP CA3742 NCI grants and Bristol Myers Squibb. Clinical trial information: NCT00655876.
Resting cardiovascular status and vasodilator function in a vasopressin-deficient, hypertensive strain of rat. (1994)

There is vasoconstriction in the hindquarters but not in renal and mesenteric vascular beds of DI/H rats. Vasodilator function is not necessarily impaired in congenital hypertension.
Observation ofB+→K¯0K+andB0→K0K¯0 (2006)

We report observations of the b --> d penguin-dominated decays B+ --> K0K+ and B0 --> K0K0 in 316 fb(-1) of e+ e- collision data collected with the BABAR detector. We measure the branching fractions B(B+ --> K0K+) = (1.61+/-0.44+/-0.09) x 10(-6) and B(B0 --> K0K0 = (1.08+/-0.28+/-0.11) x 10(-6) and the CP-violating charge asymmetry A(CP)(K0K+) = 0.10+/-0.26+/-0.03. Using a vertexing technique previously employed in several analyses of all-neutral final states containing kaons, we report the first measurement of time-dependent CP-violating asymmetries in B0 --> K(S)0K(S)0, obtaining S = -1.28(-0.73-0.16)(+0.80+0.11) and C = -0.40+/-0.41+/-0.06. We also report improved measurements of the branching fraction B(B+ --> K0 pi+) = (23.9+/-1.1+/-1.0) x 10(-6) and CP-violating charge asymmetry A(CP)(K0 pi+) = -0.029+/-0.039+/-0.010.
Towards an Improved SVC-to-AVC Rewriter (2010)

The Scalable Video Coding (SVC) extension of the H.264/AVC (AVC) video coding standard features spatial, quality and temporal scalability. Backwards compatibility with legacy decoding devices is maintained through an H.264/AVC compliant base layer, which represents the lowest quality of an SVC bit-stream. However, it is often desirable to also provide the higher quality layers to legacy H.264/AVC devices. This is achieved by a process commonly known as “bit-stream rewriting”, which allows for an efficient SVC to AVC conversion by exploiting the similarities of the two codecs. This paper introduces an improved version of the existing JSVM reference software rewriter (JSVM-rewriter). The improvements include a better run-time performance through parallel processing, as well as applicability in streaming scenarios. A detailed evaluation provides performance measurements for the improved rewriter and compares it to the existing JSVM-rewriter. The evaluation shows that notable performance improvements can be achieved using the presented approach. The paper concludes on how the rewriter could be further improved.
Critical issues in large offshore wind farm design and operation (2009)

Interest in the realization of offshore wind farms is growing even in zones where exploitation was considered unprofitable so far. For this reason, studies are needed in order to design suitable methodologies aiming to investigate economic feasibility and control strategies both in steady-state and dynamic conditions. In this work, the analysis of steady-state behaviour and investment concerns of electric system for offshore wind farms is carried out. In particular, the case of a 300-MW offshore wind farm is taken as the reference case in order to investigate issues concerning both design and operation of the electrical system of offshore wind farms.
Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology. (1997)

The interactions of caffeine (CAS 58-08-2) with acetylsalicylic acid (CAS 50-78-2, ASA) and paracetamol (CAS 103-90-2) were investigated with regard to the analgesic, antiphlogistic, antipyretic and other properties. The inhibitory effect of paracetamol and ASA on the prostaglandin biosynthesis in a cyclooxygenase preparation from bovine brain in vitro was not affected by the addition of caffeine. Caffeine additively increases the antinociceptive effect of paracetamol with regard to the heat-induced pain in the mouse, as does aminophenazone. The antinociceptive effect of aminophenazone on the mechanically induced pain in the mouse is also additively increased by caffeine. In contrast to the effect of aminophenazone on the inflammatory pain in the rat, the effect of ASA is not increased by caffeine and that of paracetamol only negligibly. The antipyretic effect of paracetamol is additively increased by caffeine in the normothermic rat. The antipyretic effect of ASA and paracetamol on the yeast-induced pyrexia of the rat is not affected by caffeine. Caffeine additively increases the acute antiexudative effect of ASA and aminophenazone on the carageenin-induced oedema of the hind paw of the rat. The increase in locomotor activity caused by caffeine in mouse and rat is neutralised or diminished when the caffeine is given in combination with paracetamol. This effect is maintained even if the rats are pretreated with the combination of active ingredients for 3 weeks. The ulcerogenic effect of ASA in the stomach of the rat is not increased by caffeine. The protective effect of ASA against the hepatotoxic effect of paracetamol in the mouse is not influenced by the addition of caffeine. The plasma levels after the oral administration of 20 mg/caffeine/ kg and 80 mg paracetamol/kg in the rat are not significantly changed when the substances are given in combination. The toxicological advantages resulting from combining ASA and paracetamol with caffeine are discussed.
From Triclosan toward the Clinic: Discovery of Nonbiocidal, Potent FabI Inhibitors for the Treatment of Resistant Bacteria (2012)

In this paper, we present some elements of our optimization program to decouple triclosan's specific FabI effect from its nonspecific cytotoxic component. The implementation of this strategy delivered highly specific, potent, and nonbiocidal new FabI inhibitors. We also disclose some preclinical data of one of their representatives, 83, a novel antibacterial compound active against resistant staphylococci and some clinically relevant Gram negative bacteria that is currently undergoing clinical trials.
Editor's Note (1977)

Beginning with this issue, Chinese Education will use the official pinyin phonetic system rather than the Wade-Giles system for transcribing Chinese words and names. A conversion table can be found on pages 103-106 of this issue.
Intrinsic steric deuterium isotope effects on proton and carbon-13 chemical shifts (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntrinsic steric deuterium isotope effects on proton and carbon-13 chemical shiftsFrank A. L. Anet and Armenag H. DekmezianCite this: J. Am. Chem. Soc. 1979, 101, 18, 5449–5451Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/ja00512a073https://doi.org/10.1021/ja00512a073research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Loss of activation-induced CD45RO with maintenance of CD45RA expression during prolonged culture of T cells and NK cells. (1991)

The results of the present study show that activation-induced changes in CD45RA and CD45RO expression on T cells and natural killer (NK) cells are not unidirectional for all cells during a 5-week culture period. T cells and NK cells were generated from a resting subpopulation of peripheral blood mononuclear cells (PBMC) defined by sedimentation at Percoll high buoyant densities (p greater than 1.0640 g/ml) and unresponsiveness to IL-2. T cells were activated by a combination of PHA, sheep erythrocytes and IL-2-conditioned medium (IL-2-CM), and NK cells were activated by co-culture with gamma-irradiated malignant melanoma (MM-170) cells and IL-2-CM. Both T-cell and NK-cell cultures were maintained by subculture in IL-2-CM. NK cells and the CD45R(Abright)RO(dim/neg) subpopulation of T cells gained CD45RO following activation and this was accompanied by a two-fold decrease in CD45RA expression. In different cultures, CD45RO expression was not stable on 28-80% of T cells and 10-55% of NK cells. Cells with decreased CD45RO expression showed increased expression of CD45RA. Instability of CD45RO expression on cultured T cells and NK cells occurred at a time following the period of rapid cell growth when the cells were entering a quiescent phase. Both the CD4+ and CD8+ T-cell subpopulation showed similar changes in CD45 isoform expression. In contrast to the results obtained with the CD45R(Abright)RO(dim/neg) resting T cells, the CD45RO(bright)RA(dim/neg) subpopulation of resting T cells when activated and cultured under identical conditions retained CD45RO expression and remained CD45RAdim/neg. Thus a significant proportion of resting CD45R(Abright)RO(dim/neg) T cells is not related in a differentiation sequence to resting CD45RObrightRAdim/neg T cells, and therefore resting CD45RAbrightROdim/neg T cells and resting NK cells may be heterogeneous with respect to their activation history.
Desempenho de argamassas leves em isolamento a sons de percussão (2008)

portuguesA actual abordagem dos codigos e regulamentos a nivel europeu impoe a limitacao a valores maximos para os indices de isolamento a sons de percussao na generalidade das utilizacoes de edificios. Frequentemente, estas exigencias levam a utilizacao de solucoes construtivas que fazem uso de sistemas ditos flutuantes, com camadas resilientes aplicadas sob o pavimento. Solucoes como lajetas flutuantes (sobre mantas de espumas sinteticas ou de fibras naturais) ou pavimentos flutuantes (p.ex. pavimentos em madeira aplicados sobre mantas de espumas sinteticas) tornaram-se comuns nos nossos dias. Em alternativa a estas solucoes, a utilizacao de camadas de enchimento leves e pouco rigidas, aplicadas sobre a laje estrutural, pode revelar-se como um contributo importante na minimizacao da transmissao dos ruidos de percussao. No presente trabalho avalia-se a melhoria proporcionada por diferentes solucoes argamassas de enchimento leves no isolamento a sons de percussao. Analisam-se, especificamente, argamassas leves com poliestireno expandido, com argila expandida e com granulado de cortica. O desempenho destas solucoes e estudado em laboratorio, com recurso a uma câmara acustica de dimensoes reduzidas, permitindo uma comparacao expedita entre diversas solucoes ensaiadas nas mesmas condicoes. EnglishMost recent European acoustic design codes and regulations establish a maximum value for percution sound insulation on pavement slabs. These requirements, demand the implementation of technical solutions such as floating floors, with the introduction of a resilient layer under the finishing pavement layer. Technical solutions such as floating concrete slabs (placed over synthetic foam or natural fibers layers), or floating pavements (like wooden floors built over synthetic foam layers) became quite common on recently built constructions. A possible alternative solution to floating pavements is the use of lightweight soft layers, applied over the structural concrete slab. These lightweight materials may present high quality results on the reduction of impact sound transmission. In the present work, lightweight mortar slabs were tested, and the impact sound insulation for different materials was quantified. Different types of cement mortar containing expanded polystyrene, expanded cork and expanded clay granulates were compared. The acoustical performance of these solutions was evaluated through laboratory tests, using an acoustic chamber with small dimensions, which allows comparing several solutions, on similar test conditions, in an expedite way.
Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis (2011)

IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because drugs targeting either cytokine are highly effective treatments for this disease. The efficacy of these drugs has been attributed to blocking the function of IL-17-producing T cells and their IL-23-induced expansion. However, we demonstrate that mast cells and neutrophils, not T cells, are the predominant cell types that contain IL-17 in human skin. IL-17(+) mast cells and neutrophils are found at higher densities than IL-17(+) T cells in psoriasis lesions and frequently release IL-17 in the process of forming specialized structures called extracellular traps. Furthermore, we find that IL-23 and IL-1β can induce mast cell extracellular trap formation and degranulation of human mast cells. Release of IL-17 from innate immune cells may be central to the pathogenesis of psoriasis, representing a fundamental mechanism by which the IL-23-IL-17 axis mediates host defense and autoimmunity.
High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura (2022)

The major therapeutic goal for immune thrombocytopenic purpura (ITP) is to restore normal platelet counts using drugs to promote platelet production or by interfering with mechanisms responsible for platelet destruction. Eighty percent of patients with ITP possess anti???integrin ??IIb??3 IgG autoantibodies that cause platelet opsonization and phagocytosis. The spleen is considered the primary site of autoantibody production by autoreactive B cells and platelet destruction. The immediate failure in approximately 50% of patients to recover a normal platelet count after anti-CD20 rituximab-mediated B cell depletion and splenectomy suggests that autoreactive, rituximab-resistant, IgG-secreting B cells (IgG-SCs) reside in other anatomical compartments. We analyzed more than 3,300 single IgG-SCs from spleen, bone marrow, and/or blood of 27 patients with ITP, revealing high interindividual variability in affinity for ??IIb??3, with variations over 3 logs. IgG-SC dissemination and range of affinities were, however, similar for each patient. Longitudinal analysis of autoreactive IgG-SCs upon treatment with the anti-CD38 mAb daratumumab demonstrated variable outcomes, from complete remission to failure with persistence of high-affinity anti?????IIb??3 IgG-SCs in the bone marrow. This study demonstrates the existence and dissemination of high-affinity autoreactive plasma cells in multiple anatomical compartments of patients with ITP that may cause the failure of current therapies.