gebhart/patrepeval huggingface dataset:
OS7.2 Measuring change in health-related quality of life: the added value of analysis on the individual patient level in glioma patients in clinical decision making (2019)

Abstract BACKGROUND Health-related quality of life (HRQoL) is often used as an outcome in glioma research, reflecting the impact of disease and treatment on a patient’s functioning and wellbeing. Data on changes in HRQoL scores may provide important information for clinical decision-making, but different analytical methods may lead to different interpretations of the impact of treatment on HRQoL. This study aimed to examine three different methods to evaluate change in HRQoL, and to study whether these methods result in different interpretations. MATERIAL AND METHODS HRQoL and sociodemographical/clinical data from 15 randomized clinical trials were combined. Change in HRQoL scores was analyzed in three ways: (1) at the group level, comparing mean changes in scale/item scores between treatment arms over time, (2) at the patient level per scale/item by calculating the percentage of patients that deteriorated, improved or remained stable on a scale/item per scale/item, and (3) at the individual patient level combining all scales/items. RESULTS Baseline and first follow-up HRQoL data were available for 3727 patients. At the group scale/item level (method 1), only the item ‘hair loss’ showed a significant and clinically relevant change (i.e. ≥10 points) over time, whereas change scores on the other scales/items showed a statistically significant change only (all p&lt;.001, range in change score: 0.1–6.2). Analyses on the patient level per scale (method 2) indicated that, while a large proportion of patients had stable HRQoL over time (range 27–84%), many patients deteriorated (range: 6–43%) or improved (range: 8–32%) on a specific scale/item. At the individual patient level (method 3), the majority of patients (86%) showed both deterioration and improvement, while only 1% of the patients remained stable on all scales. Clustering on clinical characteristics (WHO performance status, sex, tumor type, type of resection, newly diagnosed versus recurrent tumor and age) did not identify subgroups of patients with a specific pattern of change in their HRQoL score. CONCLUSION Different analytical methods of changes in HRQoL result in distinct interpretations of treatment effects, all of which may be relevant for clinical decision-making. Additional information about the joint impact of treatment on all outcomes, showing that most patients experience both deterioration and improvement, may help patients and physicians to make the best treatment decision.
Telerobotics, Automation, and Human Supervisory Control (1992)

Theory and models of supervisory control - frameworks and fragments supervisory control of anthropomorphic teleoperators for space, undersea, and other applications supervisory control in transportation, process, and other automated systems social implications of telerobotics, automation, and supervisory control.
Direct detection and spectroscopy of O4* (1997)

We have produced and directly detected a metastable state of tetraoxygen in a molecular beam, both by means of a dc discharge and by photodissociation of ozone in the collision region. The O4* produces a complex spectrum from which general conclusions may be made about its energetics and structure. The detection proceeds through a (1+1) resonant photoionization process in the vicinity of 300 nm, implying an energy for this species about 4 eV above that of two isolated O2 molecules. A predominance of peak frequency differences in the range 411–419 cm-1 supports a cyclic D2d geometry as predicted by abinitio calculations, although a definitive judgment on the structure of O4* awaits further study.
Probabilistic Temporal Logic for Motion Planning with Resource Threshold Constraints (2013)

Temporal logic and model-checking are useful theoretical tools for specifying complex goals at the task level and formally verifying the performance of control policies. We are interested in tasks that involve constraints on real-valued energy resources. In particular, autonomous gliding aircraft gain energy in the form of altitude by exploiting wind currents and must maintain altitude within some range during motion planning. We propose an extension to probabilistic computation tree logic that expresses such real-valued resource threshold constraints, and present model-checking algorithms that evaluate a piecewise control policy with respect to a formal specification and hard or soft performance guarantees. We validate this approach through simulated examples of motion planning among obstacles for an autonomous thermal glider. Our results demonstrate probabilistic performance guarantees on the ability of the glider to complete its task, following a given piecewise control policy, without knowing the exact path of the glider in advance.
BOREAS: A Global, Phase III Study of the MDM2 Inhibitor Navtemadlin (KRT-232) in Relapsed/Refractory Myelofibrosis (2022)

Patients with myelofibrosis (MF) who discontinue ruxolitinib due to progression/resistance have poor prognoses. JAK inhibitors control symptoms and reduce spleen volumes with limited impact on underlying disease pathophysiology. Murine double minute 2 (MDM2), a negative regulator of p53, is overexpressed in circulating malignant CD34<sup>+</sup> MF cells. The oral MDM2 inhibitor navtemadlin (KRT-232) restores p53 activity to drive apoptosis of wild-type <i>TP53</i> tumor cells by inducing expression of pro-apoptotic Bcl-2 family proteins. Navtemadlin demonstrated promising clinical and disease-modifying activity and acceptable safety in a phase II study in patients with relapsed/refractory MF. The randomized phase III BOREAS study compares the efficacy and safety of navtemadlin to best available therapy in patients with MF that is relapsed/refractory to JAK inhibitor treatment.
Robust Lane Detection in Shadows and Low Illumination Conditions using Local Gradient Features (2013)

This paper presents a method for lane boundaries detection which is not affected by the shadows, illumination and un-even road conditions. This method is based upon processing grayscale images using local gradient features, characteris-tic spectrum of lanes, and linear prediction. Firstly, points on the adjacent right and left lane are recognized using the local gradient descriptors. A simple linear prediction model is deployed to predict the direction of lane markers. The contribution of this paper is the use of vertical gradient image without converting into binary image(using suitable thre-shold), and introduction of characteristic lane gradient spectrum within the local window to locate the preciselane marking points along the horizontal scan line over the image. Experimental results show that this method has greater tolerance to shadows and low illumination conditions. A comparison is drawn between this method and recent methods reported in the literature.
Substitution reaction of diphenylcyclopropenone with ammonia to give α-amino-β-phenylcinnamic aldehyde (1969)

F. Toda, T. Mitote and K. Akagi, J. Chem. Soc. D, 1969, 228 DOI: 10.1039/C29690000228
High-efficiency diode-pumped femtosecond Yb:YAG ceramic laser (2010)

A highly efficient diode-end-pumped femtosecond Yb:yttrium aluminum garnet (YAG) ceramic laser was demonstrated. Pumped by a 968 nm fiber-coupled diode laser, 1.9 W mode-locked output power at a repetition rate of 64.27 MHz was obtained with 3.5 W absorbed pump power, corresponding to a slope efficiency of 76%. Our measurement showed that the pulse duration was 418 fs with the central wavelength of 1048 nm.
Industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles-catalyzed hydrogenation of nitroarenes (2022)

The development of green and efficient methods for hydrogenation of nitroarenes is still highly demanding in organic synthesis. Herein, we report an industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles process for the synthesis of aryl amines with good yields via hydrogenation of nitroarenes. Nine key anti-cancer drug intermediates were successfully achieved with protocol. And Osimertinib intermediate 4m can be smoothly synthesized at a 2.67 kg-scale with >99.5% HPLC purity. This protocol features cheap carbon source, highly catalytic activity, simple operation, kilogram-scalable and recyclable catalysts (eight times without observable losing activity).
NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis (2006)

Normal mode analysis (NMA) is an efficient way to study collective motions in biomolecules that bypasses the computational costs and many limitations associated with full dynamics simulations. The NOMAD-Ref web server presented here provides tools for online calculation of the normal modes of large molecules (up to 100,000 atoms) maintaining a full all-atom representation of their structures, as well as access to a number of programs that utilize these collective motions for deformation and refinement of biomolecular structures. Applications include the generation of sets of decoys with correct stereochemistry but arbitrary large amplitude movements, the quantification of the overlap between alternative conformations of a molecule, refinement of structures against experimental data, such as X-ray diffraction structure factors or Cryo-EM maps and optimization of docked complexes by modeling receptor/ligand flexibility through normal mode motions. The server can be accessed at the URL http://lorentz.immstr.pasteur.fr/nomad-ref.php.
Controlled selective growth of ZnO nanorod and microrod arrays on Si substrates by a wet chemical method (2006)

The use of a wet chemical method to selectively grow ZnO microrod and nanorod arrays on Si substrates is described. To control the size and position of the ZnO microrods and nanorods, polymethylmethacrylate (PMMA) submicron patterns were prepared on the Si substrates with an intermediate ZnO layer using e-beam lithography. Selective growth of the ZnO structures was achieved by the absence of ZnO nucleation sites on the PMMA mask, resulting in position-controlled growth of ZnO structures only on patterned holes where the ZnO layer was exposed. In addition, the diameters of the ZnO microrods were determined by the patterned hole size, and the diameters as small as 250nm were obtained when a hole diameter of 250nm was employed. The structural and optical characteristics of the ZnO microrods were further investigated using x-ray diffraction, transmission electron microscopy, and photoluminescence spectroscopy.
The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs (2018)

ABSTRACT Improper regulation of translation initiation, a vital checkpoint of protein synthesis in the cell, has been linked to a number of cancers. Overexpression of protein subunits of eukaryotic translation initiation factor 3 (eIF3) is associated with increased translation of mRNAs involved in cell proliferation. In addition to playing a major role in general translation initiation by serving as a scaffold for the assembly of translation initiation complexes, eIF3 regulates translation of specific cellular mRNAs and viral RNAs. Mutations in the N-terminal Helix-Loop-Helix (HLH) RNA-binding motif of the EIF3A subunit interfere with Hepatitis C Virus Internal Ribosome Entry Site (IRES) mediated translation initiation in vitro. Here we show that the EIF3A HLH motif controls translation of a small set of cellular transcripts enriched in oncogenic mRNAs, including MYC . We demonstrate that the HLH motif of EIF3A acts specifically on the 5’-UTR of MYC mRNA and modulates the function of EIF4A1 on select transcripts during translation initiation. In Ramos lymphoma cell lines, which are dependent on MYC overexpression, mutations in the HLH motif greatly reduce MYC expression, impede proliferation and sensitize cells to anti-cancer compounds. These results reveal the potential of the EIF3A HLH motif in eIF3 as a promising chemotherapeutic target.
Nonlinear Magnetooptical Effects Caused by Piezoelectric Ferromagnetism in F43m-type Prussian Blue Analogues (2005)

The second harmonic generation (SHG) and magnetization-induced SHG (MSHG) of AMA[MB(CN)6]-type (F3m) Prussian blue analogues (i.e., CsCo[Cr(CN)6].0.5H2O and RbMn[Fe(CN)6]) were observed. A large interaction between the nonlinear optical response and magnetic spins was observed in CsCo[Cr(CN)6].0.5H2O. These observations of SHG and MSHG imply that AMA[MB(CN)6]-type Prussian blue analogues are piezoelectric above the Curie temperature (TC) and piezoelectric ferromagnet below TC.
SRAM immunity to cosmic-ray-induced multierrors based on analysis of an induced parasitic bipolar effect (2004)

This paper describes an investigation of cosmic-ray-induced multicell error behavior in SRAMs. A combination of device- and circuit-level simulation was used to show that a parasitic bipolar effect is responsible for such errors, and the underlying mechanism is what we call a battery effect. We have also demonstrated, for the first time, that the maximum number of cell errors per cosmic-ray strike depends on the number of cells between well taps (Nc). The results are used as the basis of an error checking and correction (ECC) design guideline for the handling of cosmic-ray-induced multicell errors. The proposed guideline simply states that the allocation of memory cells to addresses should be based on consideration of the Nc. The architecture in its form reduces the soft error rate of an SRAM with Nc=16 by 88%.
Flat-panel autostereoscopic displays: characterization and enhancement (2000)

An analysis of the basic approaches to flat panel autostereoscopic 3D display is presented, together with a discussion of the application of LCDs in this field. We show that of particular importance in the design of parallax barrier type displays is the diffractive performance of the barriers. A near field diffraction model is used to analyze the detailed illumination structure of the output and can be used to assess viewing freedom and cross talk considerations. A comparison between front and rear parallax barrier displays is given, and compared with experimental result. Recent progress in the design of low cost flat panel 3D displays including a novel viewer position indicator and 2D/3D reconfigurable systems using novel patterned retarder elements are described. We describe the performance and manufacturing considerations for these elements.
3-D Model-Based Frame Interpolation for Distributed Video Coding of Static Scenes (2007)

This paper addresses the problem of side information extraction for distributed coding of videos captured by a camera moving in a 3-D static environment. Examples of targeted applications are augmented reality, remote-controlled robots operating in hazardous environments, or remote exploration by drones. It explores the benefits of the structure-from-motion paradigm for distributed coding of this type of video content. Two interpolation methods constrained by the scene geometry, based either on block matching along epipolar lines or on 3-D mesh fitting, are first developed. These techniques are based on a robust algorithm for sub-pel matching of feature points, which leads to semi-dense correspondences between key frames. However, their rate-distortion (RD) performances are limited by misalignments between the side information and the actual Wyner-Ziv (WZ) frames due to the assumption of linear motion between key frames. To cope with this problem, two feature point tracking techniques are introduced, which recover the camera parameters of the WZ frames. A first technique, in which the frames remain encoded separately, performs tracking at the decoder and leads to significant RD performance gains. A second technique further improves the RD performances by allowing a limited tracking at the encoder. As an additional benefit, statistics on tracks allow the encoder to adapt the key frame frequency to the video motion content.
The security of vehicular ad hoc networks (2005)

Vehicular networks are likely to become the most relevant form of mobile ad hoc networks. In this paper, we address the security of these networks. We provide a detailed threat analysis and devise an appropriate security architecture. We also describe some major design decisions still to be made, which in some cases have more than mere technical implications. We provide a set of security protocols, we show that they protect privacy and we analyze their robustness, and we carry out a quantitative assessment of the proposed solution.
Using machine learning for predicting intensive care unit resource use during the COVID-19 pandemic in Denmark (2021)

The COVID-19 pandemic has put massive strains on hospitals, and tools to guide hospital planners in resource allocation during the ebbs and flows of the pandemic are urgently needed. We investigate whether machine learning (ML) can be used for predictions of intensive care requirements a fixed number of days into the future. Retrospective design where health Records from 42,526 SARS-CoV-2 positive patients in Denmark was extracted. Random Forest (RF) models were trained to predict risk of ICU admission and use of mechanical ventilation after n days (n = 1, 2, …, 15). An extended analysis was provided for n = 5 and n = 10. Models predicted n-day risk of ICU admission with an area under the receiver operator characteristic curve (ROC-AUC) between 0.981 and 0.995, and n-day risk of use of ventilation with an ROC-AUC between 0.982 and 0.997. The corresponding n-day forecasting models predicted the needed ICU capacity with a coefficient of determination (R<sup>2</sup>) between 0.334 and 0.989 and use of ventilation with an R<sup>2</sup> between 0.446 and 0.973. The forecasting models performed worst, when forecasting many days into the future (for large n). For n = 5, ICU capacity was predicted with ROC-AUC 0.990 and R<sup>2</sup> 0.928, and use of ventilator was predicted with ROC-AUC 0.994 and R<sup>2</sup> 0.854. Random Forest-based modelling can be used for accurate n-day forecasting predictions of ICU resource requirements, when n is not too large.
Microwave testing of moist and oven-dry wood to evaluate grain angle, density, moisture content and the dielectric constant of spruce from 8 GHz to 12 GHz (2017)

The scope of this work is to discuss the challenges and demonstrate the potential of microwave testing for applications in the wood processing industry. Microwave technology benefits from the anisotropic dielectric properties of wood to simultaneously identify grain angle, density, and moisture content of wood. Therefore, the theory of free space transmission measurement is thoroughly discussed with emphasis on the characteristics of (and how to deal with) reflections occurring in real measurements. A more sophisticated calculation method for the derivation of the desired physical wood properties is presented. The advantages of a modern laboratory style setup are shown and its possible transition in an industrial-style application is discussed. Moist (moisture content 7.6–14%) and oven-dry spruce samples are tested. The detection of grain angle for moist and oven-dry wood yields an RMSE (root-mean-squared-error) of 0.14° and 0.4°, respectively. Moisture content is evaluated with density- and thickness-independent methods. Adapted regression models are proposed yielding an RMSE for moisture content of 0.45% for a single frequency measurement. The promising advantages of wood moisture estimation with frequency sweeps instead of fixed frequency signals are discussed and demonstrated for all samples (RMSE 0.39%). The dielectric constant of moist and oven dry spruce in the range from 8 to 12 GHz is evaluated in respect to density, moisture content and temperature. The respective constants ε′, ε′′, and tan(δ) are formulated in a general form via a non-linear regression and compared to existing data in literature.
Panorama to cube (2015)

As panoramas provide a brand new viewpoint for the public, relevant cameras and software such as RICOH Theta, Microsoft Photosynth are embracing more and more users. However, the display methods for panoramas remain monotonous. In this paper, we propose a novel representation method called Content-Aware Cube Unwrapping using the effective and interactive techniques of orientational rectification, image modification and energy estimation. Thus, a number of fascinating applications will come into reality. For instance, six surfaces of a Rubiks cube can be automatically rendered from a vertically oriented panorama, without cutting any person or significant object apart. Moreover, seam carving and inserting are applied to each surface to enhance the key content and to make the scenery more consistent.
Fixation de l'alphabet et de l'orthographe de la langue Kikuyu (1934)

Cohen Marcel. Fixation de l'alphabet et de l'orthographe de la langue Kikuyu. In: Journal de la Société des Africanistes, 1934, tome 4, fascicule 2. pp. 322-324.
Development of Tablet-Shaped Ingestible Core-Body Thermometer Powered by Gastric Acid Battery (2018)

In this paper, we have developed a tablet-shaped ingestible core-body temperature sensor based on gastric acid power generation for daily health care. A custom integrated circuit (IC), which had voltage boosting, bit-rate conversion, coding, modulating, and transmitting functions, was prototyped for the feasibility study of this system. A pair of Mg and Au electrodes was chosen as the negative and positive electrodes for the gastric acid battery, respectively. The battery with a diameter of 2 mm in an artificial gastric juice generated approximately 1.2 V of output voltage. Subsequently, it successfully boosted the generated voltages to more than 3.5 V by the custom IC and demonstrated the charging of a multilayer ceramic capacitor at the boosted voltage within a reasonably short time. The feasibility of mass production of the Mg thin-film-based battery on a print circuit board (PCB) was also verified through sputter deposition of a Mg thin film on a Au pad of a PCB. Next, electrical components of diameter approximately 7 mm were mounted on the PCBs and compactly packaged with a resin. Consequently, a tablet-shaped device of diameter 10 mm and height 8 mm was prototyped as a specimen for a telemetry experiment. Finally, we successfully demonstrated that the temperature data measured by the device in pork were transferred to a commercially available loop antenna as a receiver at a distance of more than 20 cm via magnetic-field coupling telecommunication. This achievement paves the way to realizing a safe and ingestible core-body thermometer for daily use.
An Experimental Investigation of R134a Clathrates with Liquid Additives (2016)

A Master of Science thesis in Mechanical Engineering by Hafiz M. Ahmad Gulzar entitled, "An Experimental Investigation of R134a Clathrates with Liquid Additives," submitted in September 2016. Thesis advisor is Dr. Saad A. Ahmed and thesis co-advisor is Dr. Mohamed Gadalla. Soft and hard copy available.
Modeling the human operator with finite-state machines (1968)

Finite-state machines and evolutionary programming for representing and analyzing performance of human operator in control of dynamic systems