gebhart/patrepeval huggingface dataset:
Mast cell activation disorder masquerading as a nervous breakdown (2017)

While mast cells have been implicated in human disease since the early 1900s, mast cell activation syndrome (MCAS) was only recently discovered and recognized as a disorder caused by aberrant release of mast cell mediator enzymes. These mediators trigger a wide variety of symptoms ranging from headache, pruritis and gastrointestinal discomfort to life-threatening anaphylaxis. MCAS is frequently unrecognized and misdiagnosed because symptoms associated with MCAS are often present in other medical conditions and are highly variable among patients. We describe a case of a 62-year-old male who presented to the emergency department (ED) with three days of recurrent flushing, diarrhea, mild edema of his hands bilaterally, and severe emotional lability with recurrent crying. In the ED, he was misdiagnosed with severe anxiety and directly sent to a mental health clinic for assistance. However, he was previously seen in allergy clinic for suspected MCAS. Fortuitously standing labs including plasma histamine, tryptase, and urine studies that were ordered in allergy clinic were drawn concurrently with the initial ED workup. He was found to have elevated histamine level during his ED episode and treatment for MCAS was initiated. In subsequent visits, his symptoms, except for episodes of “brain fog” and emotional lability, improved significantly on a combination of antihistamines, oral cromolyn sodium, and montelukast. Additionally every other day prednisone has substantially cleared the neurocognitive symptoms. This case highlights the difficulty of MCAS diagnosis and the importance of assessing for MCAS, especially in patients who have multisystem complaints.
Determinants of Survival following Hepatic Resection for Metastatic Colorectal Cancer (1998)

Hepatic resection remains the only potentially curative treatment for metastatic colorectal cancer. This retrospective review study was undertaken in an attempt to identify factors that influence patient survival following hepatic resection for metastatic colorectal cancer. From January 1978 to December 1993, a total of 301 patients underwent a total of 345 planned hepatic resections for metastatic colorectal cancer. Of those, 245 patients had one resection, 44 had two resections, and 12 had three resections. For all patients the overall median survival was 20.6 months, operative mortality was 1.1%, and overall morbidity was 17.2%. Average hospital stay was 9 days. Statistical analysis included univariate analysis using log rank comparisons, Kaplan-Meier survival curves, and multivariate analysis using Cox proportional hazards regression. The statistically significant factors that influenced survival were distribution of liver metastases, unilobar versus bilobar (p = 0.0001), resected versus nonresected (p < 0.0001), and tumor-free surgical margins versus positive margins (p = 0.001). Surprisingly, the disease-free interval and the original stage of the primary tumor did not predict survival (p = not significant). Other factors that had no influence on survival were type of resection, size and number of liver metastases, ABO blood group, and the number of perioperative blood transfusions. For those patients who underwent resection of unilobar metastases with tumor-free margins, the 5-year survival rate was 29% with a median survival of 35 months and eight survivors > 7 years. In addition, one patient with bilobar disease had survival > 7 years and five patients who had resection of hepatic metastases and extrahepatic cancer simultaneously had survival > 3 years. Our data support the concept that patients with unilobar metastatic disease who undergo surgical resection with tumor-free surgical margins can be afforded a significant opportunity at long-term survival with acceptable morbidity, mortality, and hospital stay. Also, certain patients with bilobar or extrahepatic disease (or both) who undergo complete resection can enjoy a long-term survival. In these subgroups of patients resection should be considered on an individual basis.
Toward a model of unreliability to study error prevention supports (1999)

The paper reviews aspects of system development. It focuses on system specification which aims at defining off-line error prevention supports such as training programme, ergonomic improvement or rules modification and at defining on-line error prevention supports such as assistance tools, automated tools or human-machine interfaces. A model of unreliability is proposed to describe both human and machine dysfunctions and to guide the specification of error prevention supports. One of its uses is illustrated by an application in air traffic control. The project is an experimental feasibility study which aims at assessing the impact of automation on human behaviour. This study consists of sharing tasks dynamically between a human air traffic controller and a computer based tool. Results are analysed in the light of workload, safety and unreliability.
Toward Molecular Recognition of REEs: Comparative Analysis of Hybrid Nanoadsorbents with the Different Complexonate Ligands EDTA, DTPA, and TTHA (2017)

Highly efficient tailored SiO<sub>2</sub>-based nanoadsorbents were synthesized for the selective extraction of rare-earth elements (REEs). Three different complexonates (EDTA, DTPA, and TTHA) were investigated in terms of uptake capacity and selectivity, showing capacities of up to 300 mg of RE<sup>3+</sup>/g and distinct preferential trends depending on the complexonate. EDTA-functionalized nanoadsorbents showed higher uptake for Dy<sup>3+</sup>, DTPA-functionalized ones for Nd<sup>3+</sup>, and TTHA-functionalized ones for La<sup>3+</sup>. The selectivity was even more pronounced in desorption at pH 3, with separation factors of up to 76 in ternary mixtures. A broad comparative study of single-crystal structures of the complexes between REE and the nongrafted complexonates at different pHs led to a molecular understanding of their individual modes of action. EDTA-derived nanoadsorbents combine concerted action and chelation, whereas the latter is the preferential coordination mechanism for DTPA- and TTHA-derived nanoadsorbents. These different mechanisms result in quite specific REE affinities, which opens great possibilities toward molecular recognition of REEs and for tailoring nanoadsorbents for a particular REE or group of REEs in their production from minerals and in recycling. It also brings new insights into how REEs are adsorbed on nanomaterials applied in a broad variety of fields, including bioimaging and MRI.
Radiation Damage to Amine Extractants, (II) (1965)

Radiation damage to 5 v/0 alkyl amine/kerosene modified with lauryl alcohol was studied for changes brought thereby in their behavior in Th and Pa extraction by scrubbing with 3N nitric acid, and stripping with 0.01 N nitric acid at 25°C. Eight amines were used; Tri-n-octyl amine, N-cyclohexyl dilauryl amine, N-benzyl dilauryl amine, N-cyclohexyl lauryl amine, Dilauryl amine, Amberlite LA-1, Amberlite LA-2 and Primene JM-T. These solvents were used virgin as well as irradiated by 60Co γ-ray to various doses up to 108R. No marked changes in extraction-scrubbing-stripping behavior were observed in all the amines tested, except N-cyclohexyl lauryl amine and Dilauryl amine, which tended to form either third phase or emulsion.
Capacitance-type blade-tip clearance measurement system using a dual amplifier with ramp/DC inputs and integration (1992)

The analysis and prototype results for a dual-amplifier circuit for measuring blade-tip clearance in turbine engines are presented. The capacitance between the blade tip and mounted capacitance electrode within a guard ring of a probe forms one of the feedback elements of an operational amplifier (op amp). The differential equation governing the circuit taking into consideration the nonideal features of the op amp was formulated and solved for two types of inputs (ramp and DC) that are of interest for the application. Under certain time-dependent constraints, it is shown that (1) with a ramp input the circuit has an output voltage proportional to the static tip clearance capacitance, and (2) with a DC input, the output is proportional to the derivative of the clearance capacitance. and subsequent integration recovers the dynamic capacitance. The technique accommodates long cable lengths and environmentally induced changes in cable and probe parameters. System implementation for both static and dynamic measurements having the same high sensitivity is also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
100 hidden heroes of cinema (2021)

We turn the spotlight on 100 of the undersung geniuses who make film possible, from casting directors to layout artists to stuntpeople to publicists. James Bell introduces our list.
Distribution, Neuronal Colocalization, and 17β-E2 Modulation of Small Conductance Calcium-Activated K+ Channel (SK3) mRNA in the Guinea Pig Brain (2002)

Molecular cloning has revealed the existence of three distinct small conductance (SK1-3) Ca(2+)-activated K(+) channels. Because SK channels underlie the afterhyperpolarization (AHP) that is critical for sculpturing phasic firing in hypothalamic neurons, we investigated the distribution of these channels in the female guinea pig. Both SK1 and SK3 cDNA fragments were cloned using PCR, and ribonuclease protection assay as well as in situ hybridization analysis illustrated that the SK3 channel was the predominant subtype expressed in the guinea pig hypothalamus. Combined in situ hybridization and fluorescence immunocytochemistry revealed that SK3 mRNA was expressed in GnRH, dopamine, and vasopressin neurons, and all of these neurons exhibited an AHP current. Moreover, SK3 mRNA was found in other brain areas, including the septum, bed nucleus, amygdala, thalamus, midbrain, and hippocampus. Using quantitative ribonuclease protection assay, the rank order of SK3 mRNA expression was septum >or= midbrain > rostral thalamus >or= rostral basal hypothalamus >or= caudal thalamus >or= preoptic area >> caudal basal hypothalamus >or= hippocampus. Moreover, 17beta-E2 treatment, which reduces plasma LH during the negative feedback phase, significantly increased SK3 mRNA levels in the rostral basal hypothalamus (P < 0.05; n = 6). Therefore, these findings suggest that estrogen increases the mRNA expression of SK3 channels, which may represent a mechanism by which estrogen regulates hypothalamic neuronal excitability during negative feedback.
Strength characterization of silicon microprobes in neurophysiological tissues (1990)

Strength characteristics of thin-silicon probes in neural tissues have been determined experimentally. It is shown that by proper selection of the substrate length, width, and thickness, silicon substrates can be designed and used to penetrate a variety of biological tissues without breakage or excessive dimpling. Thin-silicon structures have a maximum fracture stress which is a factor of six larger than bulk silicon, and are very flexible and capable of bending to angles larger than 90 degrees. Silicon substrates 15 microns thick x 30 microns wide can easily penetrate guinea pig and rat pia arachnoid layers with minimum dimpling and no breakage, while substrates 30 microns thick x 80 microns wide can penetrate guinea pig and rat dura mater repeatedly without breakage. Quantitative comparison on the relative toughness of neurophysiological tissues in rat and guinea pig have also been experimentally obtained.
The Results of Radiation Therapy of Limited Stage Small Cell Lung Cancer (1993)

1983년 4월부터 1991년 9월까지 가톨릭 의과대학 강남성모병원 치료방사선과에서 국한된 폐소세포암으로 확진되어 방사선치료받은 32명의 환자를 대상으로 치료성적을 후향 분석하였다. 이중 5명은 방사선 치료 단독으로 치료받았으며 27명은 화학요법과 방사선치료 병용요법을 하였다. 남녀의 비는 4.3:1 이었으며 연령분포는 24세에서 78세였다(중앙값 : 63세). 6 MV X 선에의한 방사선치료선량은 일일 160-180 cGy씩 치료하여 총 1000-6660 cGy (중앙값 4500 cGy)였다. 치료 후 완전관해율은 $37.5{\%}$ (12/32), 부분관해율은 $34.4{\%}$ (11/32)였고, 무반응은 $28.1{\%}$ (0/32)였다. 생존기간의 중앙값은 10개월이었고 1년생존율과 2년생존율은 각각 $59.4{\%}$ 와 $28.1{\%}$ 였다. 1년생존율을 유의하게 증가시키는 요소로서는 70이상의 Karnofsky수행상태(p $34{\%}$ (11명), 전신피로 $28{\%}$ (9명)에서 있었으며 오심 구토 같은 위장관 증상은 $15{\%}$ (5명) 그리고 백혈구감소증이 $3{\%}$ (1명)에서 관찰되었다. 【A retrospective analysis of various characteristics in 32 limited stage small cell lung cancer patients treated at the Department of Therapeutic Radiology in Kangnam St. Mary's Hospital, Catholic University Medical College from April 1983 to September 1991, was carried out to identify factors which had prognostic significance for survival from initiation of radiation therapy. There were 26 men and 6 women. Median age was 63 years (range: 24-78 years). The follow up duration was 1.5 to 44 months (median: 9 months). External radiation therapy was done with daily 160-180 cGy,5 fraction/week, total of 1000-6660 cGy (median: 4500 cGy) to the mediastinum by 6 MV linear accelerator. Of 32 Patients, 27 ( $84.4{\%}$ ) patients were treated with combined modality (chemotherapy plus radiation therapy), and 5 ( $15.6{\%}$ ) patients were treated with radiation therapy only. Complete responders were 12 patients ( $37.5{\%}$ ), partial responders were 11 ( $34.4{\%}$ ), and no responders were 9( $28.1{\%}$ ). Karnofsky performance status over 70 (p $34{\%}$ ), general weakness in 9( $28{\%}$ ), gastrointestinal symptoms in terms of nausea, vomiting and indigestion in 5 ( $15{\%}$ ) and leukopenia in 1 ( $3{\%}$ ).】
Management of Popliteal Sentinel Nodes in Melanoma (2011)

In our series, a high percentage of popliteal sentinel lymph nodes contained metastases, and these patients frequently also had inguinal metastases. In our patients, all inguinal metastases were associated with concomitant popliteal metastases. Although it is anatomically separate, the inguinal basin appears to be a functional extension of the popliteal basin.
Regulatory interactions governing the proliferation of T cell subsets stimulated with pokeweed mitogen. (1984)

Serial phenotyping of human peripheral blood mononuclear cells (PBMC) cultured with pokeweed mitogen (PWM) demonstrated an excess of T8+ cells after stimulation. Preferential expansion of the T8+ cell compartment was a result of T8+ cell blast transformation while T4+ cells generated fewer blasts and tended to remain as small resting cells. When the proliferative behavior of T cell subsets in PWM-stimulated PBMC with physiologic proportions of T4+ and T8+ cells was compared with that of cultures depleted of T4+ or T8+ cells, two levels of regulation of proliferation were found: without T4+ cell help, T8+ cells were unable to divide; however, in the presence of T4+ cells, PWM-stimulated T8+ cells became potent feedback inhibitors of T4+ cell proliferation. The mechanism of suppression by PWM-activated T8+ cells of T4+ cell proliferation, not only to PWM, but also to tetanus toxoid, was pursued by measuring decreased interleukin 2 (IL2) recovery from cultures containing suppressors. Although passive absorption of IL2 by PWM-activated cells could contribute to the suppression of fresh proliferative responses, as shown directly with isolated T4+ cells induced by PWM to express IL2 receptors, a much more profound suppression was mediated by PWM-activated T8+ cells. The regulation of proliferative responses of helper and suppressor T cell subsets may determine the magnitude of their subsequent interactions and thus control the ultimate outcome of in vivo physiologic and pathologic immune responses.
Scanning the Internet for ROS: A View of Security in Robotics Research (2019)

Security is particularly important in robotics, as robots can directly perceive and affect the physical world. We describe the results of a scan of the entire IPv4 address space of the Internet for instances of the Robot Operating System (ROS), a widely used robotics software platform. We identified a number of hosts supporting ROS that are exposed to the public Internet, thereby allowing anyone to access robotic sensors and actuators. As a proof of concept, and with the consent of the relevant researchers, we were able to read image sensor information from and actuate a physical robot present in a research lab in an American university. This paper gives an overview of our findings, including our methodology, the geographic distribution of publicly-accessible platforms, the sorts of sensor and actuator data that is available, and the different kinds of robots and sensors that our scan uncovered. Additionally, we offer recommendations on best practices to mitigate these security issues in the future.
The Russian entrepreneur: a study of psychological characteristics (1996)

Outlines the methodology and results of a study into entrepreneurism in the new Russian economy. Asks whether the Russian entrepreneur can be characterized as similar to entrepreneurs identified in research in Western economies. Discusses the results in the context of the debate on individual v. situational causes of entrepreneurial success. Claims it would be helpful to the promotion of business venturing in growing economies, if differences in entrepreneurial psychological profiles could not only be identified, but were indicative of the potential for training or socialization.
Efficient Synthesis of Dibenzoxaborininols from Diaryl Ethers and Their Application to Dibenzofuran Synthesis (2013)

Abstract A convenient and efficient method for the borylation of diaryl ethers leading to dibenzoxaborininols and the synthesis of dibenzofuran derivatives has been developed. The borylation involves the sequential three‐step process: lithiation, borylation and hydrolysis. The synthesized dibenzoxaborininols could be readily transformed into dibenzofuran derivatives in good to excellent yields under palladium catalysis in the presence of iodine, and this is the first example for the formation of an aryl CC bond from diarylborinic acids. magnified image
Accurately identifying patients who are excellent candidates or unsuitable for a medication: a novel approach (2017)

In two separate analyses with two different treatments, this analytic approach - which is also applicable to pretreatment laboratory tests - identified a meaningful proportion (over 20%) of depressed patients for whom a treatment outcome was predicted with sufficient certainty that the clinician can elect to strongly recommend for or choose to avoid a particular treatment. Different persons seem to be remitting or not benefiting with these two different treatments.
Isothermal self-assembly of multicomponent and evolutive DNA nanostructures (2022)

Self-assembly is both an advantageously spontaneous process to organize molecular or colloidal entities into synthetic functional superstructures and a key-feature of how life builds its components. However, compared to their living counterparts, synthetic materials made by self-assembly usually lack some of the interesting properties of living systems such as multicomponent character or capability to adapt, transform and evolve. Here we describe an isothermal multicomponent DNA self-assembly method that recapitulates all these characteristics and leads to user-defined objects with programmable shape, site-specific function, intrinsic reconfigurability and unprecedented capacity of major transformation and shape evolution. Using a generic magnesium-free buffer containing NaCl, we show that a complex cocktail of hundreds of different DNA strands can spontaneously assemble at room or body temperature to form desired DNA origamis of various shapes with site-specific protein functionalization, extended nanogrids or single-strand tile-assemblies. In situ atomic force microscopy allows us to follow the self-assembly process and demonstrate that DNA origami assembly proceeds through multiple folding pathways, the system escaping kinetic traps until it reaches its equilibrium target structure. We also show that, under thermodynamic control, this method allows a given system to self-select its most stable shape in a large pool of competitive DNA strands. We finally demonstrate the first giant morphological transformation of DNA origamis spontaneously evolving at constant temperature from one shape to a radically different one by the massive exchange of all its constitutive staple strands. This method greatly expands the repertoire of shapes and functions attainable by isothermal self-assembly as well as provides tools to design evolutive DNA assemblies, with applications ranging from directed or self-adaptive morphological changes to nanostructure optimization by evolution.
Anti‐tuberculosis Drug Discovery from Phenotypic High‐throughput Screening of Actinomycete Cultures (2018)

This report presents over a decade of efforts in anti‐tuberculosis (anti‐TB) drug discovery at the UIC Institute for Tuberculosis Research (ITR). During this period, a library of approximately 200,000 actinomycete‐derived extracts was screened directly against virulent Mycobacterium tuberculosis ( M. tb ) H37Rv using a luxABCDE reporter and the Microplate Alamar Blue Assay.1 The collection consisted of soil microorganisms from sites in Southeastern Asia with distinctive ecosystems and climate, e.g. , polar, tropical, volcanic, and deserted areas. The extracts of interest were subjected to extensive biological profiling under replicating and non‐replicating M. tb conditions, against mono‐drug resistant M. tb strains, and panels of microorganisms other than mycobacteria. The aim was to identify and validate the extracts with the most interesting activity profile by fractionation and bioassay‐guided isolation of the active principles. New approaches were implemented not only for the biological activity testing but also for the isolation and structure identification of the potential leads.2 The established anti‐TB drug discovery platform led to the discovery of the two anti‐mycobacterial cyclic peptides, ecumicin and rufomycin, which both target ClpC1 in M. tb . Support or Funding Information The Next‐Generation BioGreen 21 Program (No. PJ01328403), Rural Development Administration, Republic of Korea; and T32AT007533 from NCCIH/NIH. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Normalization of Glenohumeral Articular Contact Pressures After Latarjet or Iliac Crest Bone-Grafting (2010)

Glenohumeral contact pressure is optimally restored with a flush iliac crest bone graft or with a flush Latarjet bone block with the inferior aspect of the coracoid becoming the glenoid surface. Bone grafts placed in a proud position not only increase the peak pressure anteroinferiorly, but also shift the articular contact pressure to the posterosuperior quadrant. Glenoid bone augmentation with a Latarjet bone block with the inferior aspect of the coracoid as the glenoid surface resulted in complete restoration of the 30% anterior glenoid defect to the intact state. These findings indicate the clinical utility of a flush iliac crest bone graft and utilization of the inferior surface of the coracoid as the glenoid face for glenoid bone augmentation with a Latarjet graft.
Figure FS1 from Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer (2023)

&lt;p&gt;Fig. S1 DLL3 is expressed in small cell lung tumors, PDX models and cell lines, with limited expression in normal tissue.&lt;/p&gt;