gebhart/patrepeval huggingface dataset:
Hybrid inorganic–organic composite nanoparticles from crosslinkable polyfluorenes (2013)

Polyfluorenes with pendant alkoxysilyl groups have been used to prepare inorganic–organic composite nanoparticles (diameter = 80–220 nm) in which the conjugated polymer is dispersed within a silica matrix. Preparation of these nanoparticles is achieved by simultaneous nanoprecipitation of the conjugated polymer and hydrolysis/crosslinking of the alkoxysilyl groups under basic conditions. The composition of the nanocomposites is controlled by addition of an alkoxysilane monomer, tetramethylorthosilicate. The hybrid nanoparticles form highly stable dispersions in water and buffer (pH 9.2). The size of the nanoparticles can be tuned by varying the amount of the alkoxysilane monomer added during the nanoprecipitation process. Increasing the relative amount of alkoxysilane monomer also increases the proportion of polyfluorene chains that adopt the higher energy β-phase conformation within the resultant nanoparticles. Nanoparticles with the highest silica content were found to have increased photoluminescence quantum yields. This work provides a controllable method for optimisation of the photophysical properties of light-emitting conjugated polymer nanoparticles via a simple aqueous processing technique.
ChemInform Abstract: SUBSTANZEN MIT ANTINEOPLASTISCHER AKTIVITAET 47. MITT. S‐SUBSTITUIERTE 6‐STYRYL‐3‐THIOXO‐2,3,4,5‐TETRAHYDRO‐1,2,4‐TRIAZINONE‐(5) UND ANALOGE 3‐AMINO(HYDRAZINO)‐DERIVATE (1972)

Abstract Die Triazine (I) werden mit den Halogeniden (II) (beim Einsatz von Alkyljodiden bzw. Esterbromiden in Gegenwart von NaOH bzw. von K2CO3/DM unter Erhitzen) zu den S‐Alkyl‐triazinen (IIIa)‐(IIIf) (7‐79% Ausbeute) u gesetzt.
Notes on the genus Celotes, with the description of a new species from Mexico (Lepidoptera: Hesperiidae: Pyrginae: Pyrgini) (2008)

Warren, Andrew D., Steinhauser, Stephen R., Hernández-Mejía, Claudia, Grishin, Nick V. (2008): Notes on the genus Celotes, with the description of a new species from Mexico (Lepidoptera: Hesperiidae: Pyrginae: Pyrgini). Zootaxa 1926: 27-40, DOI: 10.5281/zenodo.184811
Secure Multicast for Mobile Commerce Applications (2008)

With the rapid growth in mobile commerce (m-commerce) applications, the need for providing suitable infrastructure to support these applications has become critical. Secure multicast is a key element of this infrastructure, in particular, to support group m-commerce applications such as mobile auctions, product recommendation systems, and financial services. Despite considerable attention to m-commerce security, most existing security solutions focus on unicast communications. On the other hand, numerous solutions for secure multicast exist that are not specifically designed with m-commerce as a target environment. Clearly, to address secure multicast in m-commerce, we must start by forming a comprehensive picture of the different facets of the problem and its solutions. In this chapter, we identify system parameters and subsequent security requirements for secure multicast in m-commerce. Attacks on m-commerce environments may undermine satisfying these security requirements resulting, at most times, in major losses. We present a taxonomy of common attacks and identify core services needed to mitigate these attacks and provide efficient solutions for secure multicast in m-commerce. Among these services, authentication and key management play a major role. Given the varying requirements of m-commerce applications and the large number of current key management schemes, we provide a taxonomy and a set of performance metrics to aid m-commerce system designers in the evaluation and selection of key management schemes.
Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection (2021)

The human pathogen Mycobacterium tuberculosis depends on host fatty acids as a carbon source. However, fatty acid β-oxidation is mediated by redundant enzymes, which hampers the development of antitubercular drugs targeting this pathway. Here, we show that rv0338c, which we refer to as etfD, encodes a membrane oxidoreductase essential for β-oxidation in M. tuberculosis. An etfD deletion mutant is incapable of growing on fatty acids or cholesterol, with long-chain fatty acids being bactericidal, and fails to grow and survive in mice. Analysis of the mutant's metabolome reveals a block in β-oxidation at the step catalyzed by acyl-CoA dehydrogenases (ACADs), which in other organisms are functionally dependent on an electron transfer flavoprotein (ETF) and its cognate oxidoreductase. We use immunoprecipitation to show that M. tuberculosis EtfD interacts with FixA (EtfB), a protein that is homologous to the human ETF subunit β and is encoded in an operon with fixB, encoding a homologue of human ETF subunit α. We thus refer to FixA and FixB as EtfB and EtfA, respectively. Our results indicate that EtfBA and EtfD (which is not homologous to human EtfD) function as the ETF and oxidoreductase for β-oxidation in M. tuberculosis and support this pathway as a potential target for tuberculosis drug development.
Polyglot: Distributed Word Representations for Multilingual NLP (2013)

Distributed word representations (word embeddings) have recently contributed to competitive performance in language modeling and several NLP tasks. In this work, we train word embeddings for more than 100 languages using their corresponding Wikipedias. We quantitatively demonstrate the utility of our word embeddings by using them as the sole features for training a part of speech tagger for a subset of these languages. We find their performance to be competitive with near state-of-art methods in English, Danish and Swedish. Moreover, we investigate the semantic features captured by these embeddings through the proximity of word groupings. We will release these embeddings publicly to help researchers in the development and enhancement of multilingual applications.
Supplementary Table S4 from Safety Run-in of Intramuscular pNGVL4a-Sig/E7(detox)/HSP70 DNA and TA-CIN Protein Vaccination as Treatment for HPV16+ ASC-US, ASC-H, or LSIL/CIN1 (2023)

&lt;p&gt;Supplementary Table S4 shows respiratory rate of study participants at each visit, including immediately pre- and 30 minutes post-vaccination&lt;/p&gt;
A novel fuzzy neural network: the vague neural network (2005)

Fuzzy neural network that combines the artificial neural network and fuzzy logic is regarded as one of promising intelligent system. Based on fuzzy theory, fuzzy neural network has its problems: fuzzy membership function is a single value which combines the evidence for and against the pattern without indicating how much there is of which, hence it cannot get the more reasonable result of classification and recognition. Vague sets is characterized by a truth-membership function and a false-membership function which can solve the problem. Based on the idea of vague set theory, in this paper, a new kind of FNN: vague neuron network (VNN) is put forward, the properties are discussed. Then the VNN is applied to the problem of fault diagnosis and shows good performance.
A fast feedback method to design easy-molding freeform optical system with uniform illuminance and high light control efficiency (2013)

A feedback method combined with fitting technique based on variable separation mapping is proposed to design freeform optical systems for an extended LED source with prescribed illumination patterns, especially with uniform illuminance distribution. Feedback process performs well with extended sources, while fitting technique contributes not only to the decrease of pieces of sub-surfaces in discontinuous freeform lenses which may cause loss in manufacture, but also the reduction in the number of feedback iterations. It is proved that light control efficiency can be improved by 5%, while keeping a high uniformity of 82%, with only two feedback iterations and one fitting operation can improve. Furthermore, the polar angle θ and azimuthal angle φ is used to specify the light direction from the light source, and the (θ,φ)-(x,y) based mapping and feedback strategy makes sure that even few discontinuous sections along the equi-φ plane exist in the system, they are perpendicular to the base plane, making it eligible for manufacturing the surfaces using injection molding.
Compression depth estimation for CPR quality assessment using DSP on accelerometer signals (2002)

Chest compression is a vital part of cardiopulmonary resuscitation (CPR). This paper demonstrates how the compression depth can be estimated using the principles of inertia navigation. The proposed method uses accelerometer sensors, one placed on the patient's chest, the other beside the patient. The acceleration-to-position conversion is performed using discrete-time digital signal processing (DSP). Instability problems due to integration are combated using a set of boundary conditions. The proposed algorithm is tested on a mannequin in harsh environments, where the patient is exposed to external forces as in a boat or car, as well as improper sensor/patient alignment. The overall performance is an estimation depth error of 4.3 mm in these environments, which is reduced to 1.6 mm in a regular, flat-floor controlled environment.
The optical detection of individual DNA-conjugated gold nanoparticle labels after metal enhancement (2003)

The detection of DNA using nanoparticles as labels is an interesting alternative to the standard fluorescence technique. It requires simpler detection equipment, resulting in higher stability and lower costs. Besides easier detection, metal enhancement allows a higher sensitivity of detection. The signal-response curve for labelled DNA before and after silver enhancement was studied, applying both atomic force microscope (AFM) and optical (reflection/transmission) measurements. The dynamic range and the sensitivity were determined for nanoparticle labelling with and without metal enhancement. Nanoparticle concentrations down to the fM range could be detected. The ultimate limit of detection, the identification of individual labels, is demonstrated for the optical readout. Therefore, AFM images of the particles were correlated with the optical signal of individual or clustered particles. We demonstrate that the optical signal allows the identification of single particles.
Results of the WEGENER/GPS‐92 Campaign (1994)

During the International GPS Service for Geodynamics (IGS) Epoch'92 campaign a special sub‐campaign was organized to occupy all WEGENER/MEDLAS SLR sites with Trimble SST GPS receivers. This campaign, WEGENER/GPS‐92, was initiated by the Institute for Applied Geodesy in cooperation with Delft University of Technology. The purpose was to observe the whole SLR network, for the first time, with GPS to establish a connection between the SLR and GPS reference frames. The dataset was analyzed at the Section Space Research and Technology, using the GIPSY software developed at the Jet Propulsion Laboratory and the Bernese GPS software version 3.4. In the analysis a weighted combination of the orbits provided by the IGS was used to model the motion of the GPS satellites. The results show a baseline length repeatability, which is a measure for the precision, in the order of 5 mm. More importantly, the GPS coordinate solution compares very well with the most recent SLR coordinate solution computed at Delft University of Technology. The rms differences are 3.8, 5.2 and 12.5 mm in North, East and Up, respectively, using 14 sites. It is therefore obvious that GPS will play an increasingly important role in the monitoring of the deformation and a further densification of this network. Especially since starting January 1, 1994 the IGS has become operational and combined orbits are being produced and made available with only a few week delay.
ChemInform Abstract: A Facile Synthesis of (4S)‐4‐((1R)‐1‐Carboxyethyl)‐1‐(tert‐ butyldimethylsilyl)azetidin‐2‐one: Key Intermediate of 1‐β‐ Methylcarbapenems. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Demand-side Energy Management Method for Building Clusters Based on Reinforcement Learning (2020)

Aiming at the problems that the feasibility of reinforcement learning in demand-side energy management needs further exploration, this paper proposes a demand-side energy management method for building clusters based on reinforcement learning. Firstly, taking the building cluster as the terminal energy load carrier, the demand-side energy management framework is constructed. Secondly, based on the virtual energy storage characteristics of intelligent buildings, a novel heat resistance-capacity (R-C) balance model and user flexibility load model of intelligent buildings are constructed, and a demand-side energy management model based on reinforcement learning is constructed by combining Q-learning algorithm. Finally, through an actual simulation case, the results of demand-side energy management and the performance of the algorithm are compared and analyzed, which verifies the effectiveness and practicability of the theoretical method proposed in this paper.
From Pairwise Comparisons and Rating to a Unified Quality Scale (2019)

The goal of psychometric scaling is the quantification of perceptual experiences, understanding the relationship between an external stimulus, the internal representation and the response. In this paper, we propose a probabilistic framework to fuse the outcome of different psychophysical experimental protocols, namely rating and pairwise comparisons experiments. Such a method can be used for merging existing datasets of subjective nature and for experiments in which both measurements are collected. We analyze and compare the outcomes of both types of experimental protocols in terms of time and accuracy in a set of simulations and experiments with benchmark and real-world image quality assessment datasets, showing the necessity of scaling and the advantages of each protocol and mixing. Although most of our examples focus on image quality assessment, our findings generalize to any other subjective quality-of-experience task.
Inhibitory Effect of Galanin on Basal and Pentagastrin-Stimulated Gastric Acid Secretion in Rats (1990)

The dose-dependent effects of galanin on basal and pentagastrin-stimulated gastric acid secretion in pentobarbital-anesthetized rats were examined. Intravenous infusion of galanin at doses of 0.31, 0.62, 1.25, 1.87, 3.11, and 6.22 nmol/kg-1/h-1 into pentagastrin-stimulated rats produced a diminution in gastric acid secretion which was maximal (54.7%) at the level of the 1.87 nmol/kg-1/h-1 dose. Furthermore, the effect was biphasic, since both lower and higher doses of peptide were less effective. At the optimum concentration of 1.87 nmol/kg-1/h-1 galanin also inhibited basal gastric acid secretion. We conclude that endogenous galanin might be involved in the physiologic regulation of gastric acid secretion.
A peptide HPLC experiment for biochemistry laboratory (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA peptide HPLC experiment for biochemistry laboratoryMartha M. Vestling Cite this: J. Chem. Educ. 1991, 68, 1, 72Publication Date (Print):January 1, 1991Publication History Received3 August 2009Published online1 January 1991Published inissue 1 January 1991https://doi.org/10.1021/ed068p72RIGHTS & PERMISSIONSArticle Views494Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (345 KB) Get e-Alerts Get e-Alerts
Decolorization of acid, disperse and reactive dyes byTrametes versicolorCBR43 (2017)

The mycoremediation has been considered as a promising method for decolorizing dye wastewater. To explore new bioresource for mycoremediation, a new white-rot fungus that could decolorize various dyes commonly used in textile industries was isolated, and its ligninolytic enzyme activity and decolorization capacity were characterized. The isolated CBR43 was identified as Trametes versicolor based on the morphological properties of its fruit body and spores, as well as through partial 18S rDNA gene sequences. Isolated CBR43 displayed high activities of laccase and Mn-dependent peroxidase, whereas its lignin peroxidase activity was relatively low. These ligninolytic enzyme activities in potato dextrose broth (PDB) medium were enhanced by the addition of yeast extract (1-10 g L<sup>-1</sup>). In particular, lignin peroxidase activity was increased more than 5 times in the PDB medium amended with 10 g L<sup>-1</sup> of yeast extract. The CBR43 decolorized more than 90% of 200 mg L<sup>-1</sup> acid dyes (red 114, blue 62 and black 172) and reactive dyes (red 120, blue 4, orange 16 and black 5) within 6 days in the PDB medium. CBR43 decolorized 67% of 200 mg L<sup>-1</sup> acid orange 7 within 9 days. The decolorization efficiencies for disperse dyes (red 1, orange 3 and black 1) were 51-80% within 9 days. The CBR43 could effectively decolorize high concentrations of acid blue 62 and acid black 172 (500-700 mg L<sup>-1</sup>). The maximum dye decolorization rate was obtained at 28°C, pH 5, and 150 rpm in the PDB medium. T. versicolor CBR43 had high laccase and Mn-dependent peroxidase activities, and could decolorize a wide variety of dyes such as acid, disperse and reactive textile dyes. This fungus had decolorizing activities of azo-type dyes as well as anthraquinone-type dyes. T. versicolor CBR43 is one of promising bioresources for the decolorization of textile wastewater including various dyes.
Improved recovery of cryopreserved cell monolayers with a hyaluronic acid surface treatment (2020)

Cryopreservation is an essential part of tissue banking and effective cryopreservation methods are critical for the development of cost-effective cell therapy products. Cell sheets are an attractive subset of cell therapy types, and cryopreservation has the potential to further drive down costs of allogeneic cell sheet therapy. This is currently a challenge as adhered cell monolayers are more susceptible to membrane damage during the freezing process. In this article, we investigate the performance of a surface-modified dressing for the cryopreservation of cells and strategies to improve cell recovery. Cryopreservation of multipotent adult progenitor cells (MAPC<sup>®</sup>) was performed on cells following their attachment to a surface for different periods of time. MAPC cells, given just 1 h to attach, washed off and were not recovered on the surface following thawing. Cells attached for longer periods, elongated further, and were more susceptible to damage from cryopreservation. A temporal window was identified that could allow cryopreservation on adherent surfaces where cells had attached to a surface without full elongation. By functionalizing the surface with coupled hyaluronic acid, cell spreading was initially retarded, thereby widening this temporal window. This approach demonstrates a novel method for enhancing the recovery of cryopreserved cell sheets on surfaces.
A four harmonic wideband impedance tuner (2009)

A slide screw microwave impedance tuner is presented which has four independent carriages, which slide across a low loss slabline. Each carriage has one or two vertical axes and associated stepper motors and gear, allowing the precise positioning of RF probes (slugs) into the slot of the slabline at any horizontal or vertical position. Each RF probe generates wideband reflection when approaching the center conductor. The associated calibration and tuning software can identify combinations of tuner probe positions corresponding to reflection factors such as to create independent tuning at up to four different frequencies. In case of harmonic frequencies the coverage of the RF probes has to be at least two octaves, i.e.: maximum: minimum frequency ¿ 4:1; in practice frequency coverage is higher than 4:1, since most applications require a certain operation bandwidth; in the typical case of a fundamental frequency band of 1.8-2.5 GHz the frequency range covered by the RF probes needs to be 1.8 to 10 GHz, the maximum frequency being 4 · 2.5 GHz = 10 GHz..
Phase I study of HER3 targeted antibody patritumab in combination with trastuzumab and paclitaxel in patients with HER2-overexpressing metastatic breast cancer (MBC). (2015)

584 Background: It is considered that HER2-HER3 heterodimerization is mechanically important in HER2-overexpressing breast cancer. Patritumab is a fully human anti-HER3 monoclonal antibody, which inhibits ligand binding, receptor activation and induces HER3 down-regulation. This study aimed to assess recommended dose for subsequent studies as well as the safety, pharmacokinetics (PK), and preliminary efficacy of patritumab in combination with trastuzumab and paclitaxel in patients with HER2-overexpressing MBC. Methods: This study was an open-label, multicenter phase I study in patients with HER2-overexpressing MBC who had progressed after at least one prior chemotherapy regimen including trastuzumab. Patients received patritumab 9 mg/kg or 18 mg/kg i.v. Q3W, trastuzumab 8 mg/kg loading dose, followed by 6 mg/kg maintenance dose i.v. Q3W, and paclitaxel 175 mg/m2 i.v. Q3W or 80 mg/m2i.v. 2 weeks administration followed by 1 week rest (Q3W). Results: Eighteen patients were enrolled in total in this study. As of the October 10, 2014 cutoff, four patients were continuing treatment. All patients had received prior trastuzumab and 66.7% patients had received prior paclitaxel. No DLTs were observed. The most common ( ≥ 50.0%) adverse events (AEs) were diarrhea (88.9%), alopecia (72.2% ), leukopenia (72.2%), neutropenia (66.7%), and rash maculo-papular (50.0%). Some AEs including leukopenia and neutropenia were more frequent in patients received paclitaxel 175 mg/m2i.v. Q3W. These AEs were generally mild and manageable. As a serious adverse event (SAE), cataract was reported in one patient and it was not related to study drugs. All patients were negative for anti-patritumab antibodies. The target trough serum concentration of patritumab was achieved in all patients at a dose of 18 mg/kg. The response rate was 38.9% (2 CR and 5 PR). The median progression-free survival was 274 days. Conclusions: Patritumab in combination with trastuzumab and paclitaxel was well tolerated up to 18 mg/kg and the preliminary efficacy was encouraging in patients with HER2-overexpressing MBC. Clinical trial information: JapicCTI-121772.