gebhart/patrepeval huggingface dataset:
ChemInform Abstract: PHOSPHORUS PENTOXIDE IN ORGANIC SYNTHESIS. XV. A NEW SYNTHESIS OF ADENINES FROM 4‐ACYLAMINO‐1H‐IMIDAZOLE‐5‐CARBONITRILES (1985)

Abstract Erhitzen des Acetylamins (Ia) mit P 2 O 5 , Bu 3 N und den Aminen (III) gibt bei 180°C die Purine (II), während bei einer Arbeitstemp. von 240°C die demethylierten Produkte (IV) erhalten werden.
MISO concepts for frequency-selective channels (2003)

In order to limit interference and increase system capacity in CDMA systems, the transmitted power required to achieve a certain performance should be as low as possible. Usually, receivers are designed to overcome the problems caused by the frequency-selective wireless channel. However, if the channel impulse response (CIR) is a priori known at the transmitter, the signal we want to transmit can be preprocessed. The CIR for the downlink can be estimated in the uplink in time-division duplex (TDD) systems or conveyed in a feedback channel from the receiver to the transmitter. By using multiple transmit antennas in multiple-input single-output (MISO) systems, performance improvement potentials are created. Several MISO concepts using FIR filters both in the transmitter and receiver are compared, their decision variables are given and the SNRs at the receivers are calculated analytically. The MISO generalized selection eigenprecoder is derived which offers the possibility to trade off performance and complexity.
The Aromatase Knock-Out Mouse Provides New Evidence That Estradiol Is Required during Development in the Female for the Expression of Sociosexual Behaviors in Adulthood (2002)

We used estrogen-deficient aromatase knock-out (ArKO) mice to determine whether estrogens contribute to the development of the brain and behavior in females. Female mice of three different genotypes [i.e., wild type (WT), heterozygous (HET), and homozygous (ArKO)] were ovariectomized in adulthood and subsequently tested for odor preferences (choice: intact male vs estrous female) in a Y-maze. When treated with testosterone, ArKO females spent significantly less time sniffing odors (both volatile and nonvolatile) from either male or female stimuli compared with WT and HET females. When given direct access to anesthetized stimulus animals or when given a choice between odor and visual cues from both stimulus animals, ArKO females continued to spend less time investigating the stimuli compared with WT and HET females. These defects in olfactory investigation of ArKO females were partially corrected with estradiol treatment in adulthood. Estradiol-treated ArKO females no longer differed from WT and HET females in the time spent investigating either nonvolatile odors or the anogenital region of anesthetized animals. However, ArKO females still investigated volatile odors and/or visual cues less than WT and HET females. Sexual receptivity was severely impaired in ArKO females after treatments with estradiol and progesterone that successfully induced receptivity in WT and HET females. Furthermore, ArKO females showed diminished levels of male sexual behaviors, whereas WT and HET females readily mounted an estrous female. Together, these findings demonstrate that estrogen is required for normal female development. The concept that the female brain develops in the absence of any hormonal stimulation should therefore be reconsidered.
자유와 상황의 충돌의 재현 : 『레 망다랭』의 다성화 전략 (2019)

본 논문은 시몬 드 보부아르의 『레 망다랭』의 전반부를 중심으로, 자유와 상황이 맺고 있는 대립적이면서도 상호적인 관계를 재현하는 데 있어서 작가가 택한 다성화 전략이 어떠한 기여를 하고 있는가를 살펴보는 것을 목적으로 한다. 『레 망다랭』은 제2차 세계대전을 겪으면서 자유와 상황을 조화롭게 종합할 수 있는 실질적인 가능성을 모색해야 할 필요성을 절감하게 된 보부아르의 인식을 담고 있는 중요한 문학적 결과물에 해당한다. 이 작품의 내용은 자유의 가치를 중시하며 살아가는 앙리와 상황의 무게에 짓눌려 살아가는 안느라는 두 주인공이 겪는 실패담 및 인간다운 삶에 대한 재인식 과정으로 요약될 수 있다. 이야기의 전반부에서는 두 주인공의 실패담이 집중적으로 그려지고 있는데, 이를 재현하기 위한 서술 방식으로 작가가 활용하고 있는 것이 바로 음악 기법의 하나인 대위법에 입각한 다성화 전략이다. 텍스트가 앙리와 안느 간에 이루어지는 대화의 형태를 띠도록 하는 이 전략을 통해 자유와 상황이 맺고 있는 대립적이면서도 상호적인 관계를 가시화함으로써, 보부아르는 진정한 실존은 자유와 상황 모두를 중시할 때에만 구현될 수 있는 것이라 보았던 자신의 입장을 문학적으로 형상화하고자 했다.
Preparation of .beta.-keto esters by 4-DMAP-catalyzed ester exchange (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of .beta.-keto esters by 4-DMAP-catalyzed ester exchangeDouglass F. Taber, John C. Amedio Jr., and Yogesh K. PatelCite this: J. Org. Chem. 1985, 50, 19, 3618–3619Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/jo00219a035https://doi.org/10.1021/jo00219a035research-articleACS PublicationsRequest reuse permissionsArticle Views1854Altmetric-Citations124LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Uncovering the Binding and Specificity of β-Wrapins for Amyloid-β and α-Synuclein (2016)

Amyloidogenic proteins amyloid-β peptide (Aβ) and α-synuclein (α-syn) self-assemble into fibrillar amyloid deposits, senile plaques and Lewy bodies, pathological features of Alzheimer's and Parkinson's diseases, respectively. Interestingly, a portion of Alzheimer's disease cases also exhibit aggregation of α-syn into Lewy bodies, and growing evidence also suggests that Aβ and α-syn oligomers are toxic. Therefore, the simultaneous inhibition through sequestration of the two amyloidogenic proteins may constitute a promising therapeutic strategy. Recently discovered β-wrapin proteins pave the way toward this direction as they can inhibit the aggregation and toxicity of both Aβ and α-syn. Here, we used computational methods, primarily molecular dynamics simulations and free energy calculations, to shed light into the key interaction-based commonalities leading to the dual binding properties of β-wrapins for both amyloidogenic proteins, to identify which interactions potentially act as switches diminishing β-wrapins' binding activity for Aβ/α-syn, and to examine the binding properties of the current most potent β-wrapin for Aβ. Our analysis provides insights into the distinct role of the key determinants leading to β-wrapin binding to Aβ and α-syn, and suggests that the Aβ <sub>18</sub>VFFAED<sub>23</sub> and α-syn <sub>38</sub>LYVGSK<sub>43</sub> are key domains determining the binding specificity of a β-wrapin. Our findings can potentially lead to the discovery of novel therapeutics for Alzheimer's and Parkinson's diseases.
Enzyme-Catalysed Conversion of Atranol and Derivatives into Dimeric Hydrosoluble Materials: Application to the Preparation of a Low-Atranol Oakmoss Absolute (2018)

Oakmoss absolute, a solvent extract from Evernia prunastri, is a valuable fragrance ingredient widely used in fine fragrance for almost two centuries. Some minor components of oakmoss absolute, such as atranol and chloroatranol, are attested contact allergens and their presence in fragrance and cosmetic products should be as low as possible. In this context, we have developed an enzyme-based protocol upon which these undesirable molecules are converted in a hydrosoluble dimeric material, and thus easily separated from the absolute by liquid–liquid extraction. Analytical and sensory analyses were performed to confirm the specificity of the process, the absence of alteration of the olfactory quality of the absolute, and the final titles of atranol and chloroatranol, which eventually were observed in the ppm range. This highly sustainable process is a viable alternative to conventional time-, energy-, and manpower-consuming techniques to produce very low-atranol oakmoss absolute.
Predictive Algorithms for Browser Support of Habitual User Activities on the Web (2005)

Routine user activities on the Web result in the revisitation of Web sites and pages. Standard browser applications provide limited support for this type of habitual behaviour. They typically expose lists of visited URLs that are automatically recorded by the system or manually created by the user, such as bookmarks. Studies have shown that these approaches are not successful in supporting routine user activities. Informed by our user research, we designed a browser feature that automatically exposes candidate URLs for revisitation by the user. In this paper, we describe and evaluate the algorithms that we use to model the user's habitual behaviour. We demonstrate how a structured navigation history model facilitates the discovery of relevant usage patterns and supports predictive algorithms that are applicable to relatively short personal navigation histories.
Short‐term outcomes in patients with lung cancer‐associated acute ischemic stroke (2022)

In this study, we have identified three independent risk factors associated with poor short-term outcomes in pLCAIS: higher NC, CRP, and D-dimer levels. These findings may be helpful for clinicians in identifying poor short-term outcomes patients.
Dynamic Pressure of Seabed around Buried Pipelines in Shallow Water (2015)

Due to the obvious nonlinear effect caused by the shallow waves, the nonlinear wave loads have a great influence on the buried pipelines in shallow water. In order to ensure their stability, the forces on the pipelines that resulted from nonlinear waves should be considered thoroughly. Based on the Biot consolidation theory and the first-order approximate cnoidal wave theory, analytical solutions of the pore water pressure around the buried pipelines in shallow water caused by waves are firstly derived in this paper. The dynamic response of the seabed around the pipelines under the action of irregular waves is explored in laboratory, and the results are compared with the analytical ones. Experiments show that the maximum value of the pore water pressure is at the upper part of the pipelines, and the value at the bottom of the pipelines is the minimum. The pore water pressure amplitude at the upper half of the seabed that arises from waves has a larger fluctuation, and the amplitude at the lower half remains stable. For the sandy seabed, the pore water pressure at the same depth changes over time, with the fluctuating amplitude, and the theoretical values meet well with the test results.
Cooperative nitrogen insertion processes: Thermal transformation ofNH3on a Si(100) surface (2007)

The thermal behavior of an ammonia-covered Si(100) surface is investigated by infrared spectroscopy and density functional methods. Upon adsorption at room temperature, $(\mathrm{Si})\mathrm{N}{\mathrm{H}}_{2}$ and Si-H species are formed on the surface. Comparison of the vibrational studies with density functional calculations suggests that the $(\mathrm{Si})\mathrm{N}{\mathrm{H}}_{2}$ structures are preferentially located on the same side along the silicon dimer row on a $(2\ifmmode\times\else\texttimes\fi{}1)$ reconstructed Si(100) surface, although a mixture of different long-range configurations is likely formed. Decomposition of these $(\mathrm{Si})\mathrm{N}{\mathrm{H}}_{2}$ species is observed to start at temperatures as low as $500\phantom{\rule{0.3em}{0ex}}\mathrm{K}$. Theoretical predictions of the vibrational modes indicate that at this point, the spectrum is composed of a combination of ${(\mathrm{Si})}_{2}\mathrm{N}\mathrm{H}$ and ${(\mathrm{Si})}_{3}\mathrm{N}$ vibrational signatures, which result from insertion of N into Si-Si bonds. Our computational study of the formation of ${(\mathrm{Si})}_{2}\mathrm{N}\mathrm{H}$ structures indicates that subsurface insertion is more feasible if the strain imposed during the insertion in a Si dimer is attenuated by a ${(\mathrm{Si})}_{2}\mathrm{N}\mathrm{H}$ structure already inserted in the neighboring dimer along the same silicon dimer row. This cooperative reaction lowers the energetic requirements for subsurface insertion, providing a theoretical explanation for the mechanism of thermal decomposition of $\mathrm{N}{\mathrm{H}}_{3}$ on Si(100) and for other systems where subsurface migration is observed experimentally.
Volatile Anaesthesia (2017)

Mathematical modelling and model-based control of anaesthesia attracted the attention of researchers during the past decades and are believed to benefit the safety of the patient undergoing surgery and provide anaesthetists with valuable insights. The expectations are that detailed modelling and optimized regulation of anaesthesia could pave the way for personalized healthcare, where the individual patient characteristics are taken into account for optimal and flexible drug administration. Volatile anaesthetics are preferred by most anaesthetists to provide hypnosis, because the concentration of the anaesthetic in the expired air is directly related to the partial pressure in the brain and thus gives a direct feedback of the hypnotic state of the patient. Pharmacodynamics describes the link between the concentration of the anaesthetic agent and the effect of the drug.
Canine granulocytopathy syndrome: an inherited disorder of leukocyte function. (1979)

A disease closely resembling the human neutrophil dysfunction syndromes has been identified in a colony of dogs. The syndrome, referred to as the canine granulocytopathy syndrome, is characterized by recurrent-life-threatening bacterial infections and a greatly shortened life span. The disease is genetically determined, being transmitted as an autosomal recessive trait. The increased susceptibity to pyogenic infections and shortened life span is related to an impairment of leukocyte function at the cellular level. Preparation of neutrophils from affected animals exhibit impaired in vitro killing of Esherichia coli. The defect in bactericidal activity is associated with reduced glucose oxidation by the hexose monophosphate shunt and an increase capacity to reduce nitroblue tetrazolium dye. The data obtained thus far indicate the canine granulocytopathy syndrome will be of considerable value as a model for study of granulocytypathy sydromes in man.
Thermoresponsive, redox-polymerized cellulosic hydrogels undergo in situ gelation and restore intervertebral disc biomechanics post discectomy (2018)

Back and neck pain are commonly associated with intervertebral disc (IVD) degeneration. Structural augmentation of diseased nucleus pulposus (NP) tissue with biomaterials could restore degeneration-related IVD height loss and degraded biomechanical behaviors; however, effective NP replacement biomaterials are not commercially available. This study developed a novel, crosslinked, dual-polymer network (DPN) hydrogel comprised of methacrylated carboxymethylcellulose (CMC) and methylcellulose (MC), and used in vitro, in situ and in vivo testing to assess its efficacy as an injectable, in situ gelling, biocompatible material that matches native NP properties and restores IVD biomechanical behaviors. Thermogelling MC was required to enable consistent and timely gelation of CMC in situ within whole IVDs. The CMC-MC hydrogel was tuned to match compressive and swelling NP tissue properties. When injected into whole IVDs after discectomy injury, CMC-MC restored IVD height and compressive biomechanical behaviors, including range of motion and neutral zone stiffness, to intact levels. Subcutaneous implantation of the hydrogels in rats further demonstrated good biocompatibility of CMC-MC with a relatively thin fibrous capsule, similar to comparable biomaterials. In conclusion, CMC-MC is an injectable, tunable and biocompatible hydrogel with strong potential to be used as an NP replacement biomaterial since it can gel in situ, match NP properties, and restore IVD height and biomechanical function. Future investigations will evaluate herniation risk under severe loading conditions and assess long-term in vivo performance.
Response regulator–mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast (2013)

The Spc1 mitogen-activated protein kinase (MAPK) cascade in fission yeast is activated by two MAPK kinase kinase (MAPKKK) paralogues, Wis4 and Win1, in response to multiple forms of environmental stress. Previous studies identified Mcs4, a "response regulator" protein that associates with the MAPKKKs and receives peroxide stress signals by phosphorelay from the Mak2/Mak3 sensor histidine kinases. Here we show that Mcs4 has an unexpected, phosphorelay-independent function in promoting heteromer association between the Wis4 and Win1 MAPKKKs. Only one of the MAPKKKs in the heteromer complex needs to be catalytically active, but disturbing the integrity of the complex by mutations to Mcs4, Wis4, or Win1 results in reduced MAPKKK-MAPKK interaction and, consequently, compromised MAPK activation. The physical interaction among Mcs4, Wis4, and Win1 is constitutive and not responsive to stress stimuli. Therefore the Mcs4-MAPKKK heteromer complex might serve as a stable platform/scaffold for signaling proteins that convey input and output of different stress signals. The Wis4-Win1 complex discovered in fission yeast demonstrates that heteromer-mediated mechanisms are not limited to mammalian MAPKKKs.
Reforma política y perspectivas para una transición democrática en el Golfo Pérsico (2005)

Dentro de un contexto de creciente enfasis en Estados Unidos sobre la reforma politica en Oriente Medio como objetivo central de su politica exterior, este informe analiza los procesos de reforma politica que han tenido lugar en la ultima decada en los Estados que forman el Consejo de Cooperacion para los Estados Arabes del Golfo Persico. Mediante el analisis de las reformas en Bahrein, Qatar, Kuwait, Oman, los Emiratos Arabes Unidos y Arabia Saudi, el informe trata de explicar los limites de la liberalizacion, y senala el papel desempenado por la presion externa y nacional. Tras analizar la reforma politica en relacion con factores estructurales economicos, institucionales y sociales, el informe concluye con una serie de recomendaciones politicas para aquellos actores occidentales involucrados en la promocion de la liberalizacion politica en el Golfo Persico, y que son: - garantizar que las politicas exteriores no obstaculizan la reforma; - hacer hincapie en los cambios estructurales y la construccion de instituciones; y - ser selectivos a la hora de trasplantar modelos concretos de sistemas politicos
Malignant germ cell tumors in men infected with the human immunodeficiency virus: natural history and results of therapy. (1995)

The natural history of GCTs is comparable in HIV-infected and non-HIV-infected men and standard therapy including orchiectomy, retroperitoneal lymph node dissection, radiation therapy, and chemotherapy is well tolerated.
Metal-Free Brønsted Acid Catalyzed Formal [3 + 3] Annulation. Straightforward Synthesis of Dihydro-2H-Chromenones, Pyranones, and Tetrahydroquinolinones (2009)

Brønsted acids catalyze the addition of enolizable beta-diketones, beta-ketoesters, and vinylogous amides to alpha,beta-unsaturated aldehydes to lead to substituted chromenones, pyranones, and tetrahydroquinolinones in good yields under mild reaction conditions via a formal [3 + 3] cycloaddition.
Advances in Quantitative Structure Property Relationships. Volume 2 Edited by Marvin Charton (Pratt Institute) and Barbara I. Charton (St. John's University). JAI Press Inc.:  Stamford, CT. 1999. xi + 257 pp. $109.50. ISBN 0-7623-0067-1. (1999)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewAdvances in Quantitative Structure Property Relationships. Volume 2 Edited by Marvin Charton (Pratt Institute) and Barbara I. Charton (St. John's University). JAI Press Inc.: Stamford, CT. 1999. xi + 257 pp. $109.50. ISBN 0-7623-0067-1.Alan R. KatritzkyView Author Information University of FloridaCite this: J. Am. Chem. Soc. 2000, 122, 8, 1846Publication Date (Web):December 22, 1999Publication History Published online22 December 1999Published inissue 1 March 2000https://pubs.acs.org/doi/10.1021/ja995762chttps://doi.org/10.1021/ja995762cbook-reviewACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views117Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Bioinformatics and computational biology,Chemical structure,Quantitative structure property relationship,Structure activity relationship,Transition temperature Get e-Alerts
Decreased expression of microRNA-125b may contribute to the pathogenesis of hepatocellular carcinoma (2010)

Introduction: . microRNA (miR), that posttranscriptionally regulate expression of numerous cellular genes by targeting mRNA, play an important role in cell proliferation and differentiation. Dysregulation of miRNA expression, particularly of miR-125b, was shown to be involved in carcinogenesis. We here focused on the expression and putative pathogenic role of miR-125b in development of hepatocellular carcinoma (HCC).