gebhart/patrepeval huggingface dataset:
ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway (2020)

Growing incidence of lung adenocarcinoma (LUAD) has been detected recently. Multiple long non-coding RNAs (lncRNAs) have been proven as tumor facilitators or inhibitors by extensive works. Present study concentrated on characterizing the potential role of LINC01123 in LUAD. We explored the differential expression of LINC01123 through qRT-PCR and found the amplification of LINC01123 in LUAD cell lines. It was ascertained that LINC01123 was definitely responsible for the malignant processes of LUAD cells. Further, we validated the ceRNA network of LINC01123/miR-449b-5p/NOTCH1 in LUAD via mechanical experiments. As a transcriptional factor related to epithelial mesenchymal transition (EMT), ZEB1 was responsible for the transcriptional activation of both LINC01123 and NOTCH1. The involvement of NOTCH signaling in LUAD was interrogated through evaluating functional changes after treating with FLI-06 (NOTCH pathway suppressor). It showed that FLI-06-caused NOTCH signaling inactivation suppressed malignant functions in LUAD cells. Additionally, LINC01123 facilitated NOTCH1-dependent NOTCH signaling activation. Rescue experiments probed the modulatory function of LINC01123/miR-449b-5p/NOTCH1 in LUAD cellular processes. Altogether, ZEB1-activated LINC01123 accelerates the malignancy in LUAD through miR-449b-5p/NOTCH1 axis-mediated NOTCH signaling pathway, while NOTCH1 boosts ZEB1 in return. These observations suggest the huge potential of LINC01123 as a new target for LUAD therapy.
Inhaled iloprost is a potent acute pulmonary vasodilator in HIV‐related severe pulmonary hypertension (2004)

As antiretroviral therapy has improved life expectancy in human immunodeficiency virus (HIV) infection, the life-limiting complication of HIV-related pulmonary hypertension has come into focus. Inhalation of the stable prostacyclin analogue iloprost is an effective treatment for various forms of precapillary pulmonary hypertension. The main objective of the present study was to evaluate the safety and efficacy of inhaled iloprost in HIV-related pulmonary hypertension. In eight patients with severe pulmonary hypertension related to HIV infection, right heart and femoral artery catheterisation were performed. The acute effect of oxygen, inhaled nitric oxide and aerosolised iloprost was investigated. Four patients underwent long-term treatment with inhaled iloprost. The rank order of pulmonary vasodilatory potency was iloprost>NO>O2, with a maximum reduction (mean +/- SEM) in pulmonary vascular resistance of 30.6 +/- 3.1% (p < 0.001), 5.9 +/- 3.9% and -0.6 +/- 3.9%, respectively. Concomitantly, inhaled iloprost significantly increased the cardiac index and central venous oxygen saturation. Chronic treatment with inhaled iloprost tended to improve the 6 min walking distance and decreased pulmonary vascular resistance in all patients (although not significantly). No serious adverse events and no major interactions with the ongoing antiretroviral therapy were noted. In conclusion, inhaled iloprost is a potent pulmonary vasodilator in human immune deficiency virus-related pulmonary hypertension. Future studies are warranted to confirm the encouraging long-term beneficial results observed in the present limited number of patients.
Compressibility of 18 Molecular Organic Solids to 45 kbar (1971)

New compressibility data on 18 organic solids are reported. Measurements on a number of these solids have been made for the first time. Compressibilities up to 45 kbar were determined by observing piston displacement in a static high-pressure apparatus. Related compounds show a progressive decrease in compressibility with increase in molecular volume.
MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence (2015)

Among a number of non-coding RNAs, role of microRNAs (miRNAs) in cancer cell proliferation, cancer initiation, development and metastasis have been extensively studied and miRNA based therapeutic approaches are being pursued. Prostate cancer (PCa) is a major health concern and several deregulated miRNAs have been described in PCa. miR-212 is differentially modulated in multiple cancers however its function remains elusive. In this study, we found that miR-212 is downregulated in PCa tissues when compared with benign adjacent regions (n = 40). Also, we observed reduced levels of circulatory miR-212 in serum from PCa patients (n = 40) when compared with healthy controls (n = 32). Elucidating the functional role of miR-212, we demonstrate that miR-212 negatively modulates starvation induced autophagy in PCa cells by targeting sirtuin 1 (SIRT1). Overexpression of miR-212 also leads to inhibition of angiogenesis and cellular senescence. In conclusion, our study indicates a functional role of miR-212 in PCa and suggests the development of miR-212 based therapies.
COMPOSITION OF LACTIC ACID PRODUCTION OF A HIGHLY CONCENTRATED ACID (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCOMPOSITION OF LACTIC ACID PRODUCTION OF A HIGHLY CONCENTRATED ACIDPaul D. WatsonCite this: Ind. Eng. Chem. 1940, 32, 3, 399–401Publication Date (Print):March 1, 1940Publication History Published online1 May 2002Published inissue 1 March 1940https://pubs.acs.org/doi/10.1021/ie50363a027https://doi.org/10.1021/ie50363a027research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO Nanostructures (2017)

Ag/Ag@AgCl/ZnO hybrid nanostructures are embedded in a hydrogel by a simple two-step technique. The Ag/Ag@AgCl nanostructures are assembled in the hydrogel via ultraviolet light chemical reduction followed by incorporation of ZnO nanostructures by NaOH precipitation. The hydrogel accelerates wound healing and exhibits high antibacterial efficiency against both Escherichia coli and Staphylococcus aureus under visible light irradiation. The Ag/Ag@AgCl nanostructures enhance the photocatalytic and antibacterial activity of ZnO due to the enhancement of reactive oxygen species by visible light. This hydrogel system kills 95.95% of E. coli and 98.49% of S. aureus within 20 min upon exposure to simulated visible light, and rapid sterilization plays a crucial role in wound healing. In addition, this system provides controllable, sustained release of silver and zinc ions over a period of 21 days arising from the reversible swelling-shrinking transition of the hydrogel triggered by the changing pH value in the biological environment. About 90% Zn<sup>2+</sup> release is observed in the acidic environment after 3 days, whereas only 10% Zn<sup>2+</sup> release occurs in the neutral environment after 21 days. In vivo results show that release of Ag<sup>+</sup> and Zn<sup>2+</sup> stimulates the immune function to produce a large number of white blood cells and neutrophils (2-4 times more than the control), thereby producing the synergistic antibacterial effects and accelerated wound healing.
Mechanism of Late In-Stent Restenosis After Implantation of a Paclitaxel Derivate–Eluting Polymer Stent System in Humans (2002)

Restenotic lesions from QuaDS-QP2-eluting stents at 12 months show persistent fibrin deposition with varying degrees of inflammation. These pathological changes, representing delayed healing, are usually observed up to only 3 months in human coronary arteries with stainless steel balloon-expandable stents. The nonreabsorbable polymer alone may have induced chronic inflammation.
New strategies for gridded physical design for 32nm technologies and beyond (2009)

In this invited talk, we present a physical design solution for manufacturability in advanced technology nodes that is significantly different than existing approaches based on DFM analysis tools and rules-based restrictions. This new gridded design strategy optimizes layout efficiency, conforms to existing CAD flows, and results in improved device and interconnect formation, which in turn reduces sub-threshold leakage and electrical variability.
Couches minces et optiques multicouches dans le domaine spectral XUV (1 nm à 60 nm) (2010)

The XUV spectral domain (1-60 nm wavelength range) has experienced rapid growth in recent years. On one side, the sources (synchrotron radiation, harmonic generation, x-ray laser, free-electron laser ...) require ever more efficient optics, on the other hand, applications (diagnostics of hot plasma, solar physics, x-ray microscopy, EUV lithography, x-ray analysis ...) provide new constraints on the design of multilayer stacks. The multilayer mirrors are the only way to achieve efficient optics operating at non-grazing incidence angles in this spectral range. Our work within the team XUV Optics at Laboratoire Charles Fabry de l'Institut d'Optique focuses on the study of materials in thin layers correlated to the study of optical properties of multilayers. The objective is to achieve new multilayer components previously unavailable in the XUV domain, through a better understanding of physical phenomena in these nanolayer stacks. We show through several examples of how we have managed both to improve the performance of multilayer mirrors in a broad spectral range, and secondly, to develop new optical functions: beamsplitters, broadband mirrors, dual-band mirrors or phase compensation mirrors.
Craniopharyngiomas of the Third Ventricle: Trans-Lamina Terminalis Approach (2000)

In our experience, the trans-lamina terminalis approach is a valid choice for the removal of purely intraventricular craniopharyngiomas. These tumors can be removed without significant sequelae related to the surgical approach. The proximity to the hypothalamus requires accurate neuroendocrine and electrolyte control in the postoperative period, in some cases even years after surgery.
Circumplexer: a Novel Dual-Band Dual-Circular Polarization Antenna Feeding Network for Satellite Communications (2022)

In this paper, Anteral presents a novel dual-band dual-circular polarization antenna feeding network for satellite communications. Circumplexer is the idea of Anteral for compactness of an antenna feeding network by integrating a septum in the common port of a diplexer. Therefore, the new device provides dual circular polarization with excellent axial ratio levels and very high isolation between channels simultaneously. Two different waveguide filters are utilized to provide very high isolation between two different channels while a septum in the common port is used to provide with the dual circular polarization. This kind of components is presented for the first time in the literature. The proposed design example accomplishes measured results with more than 23 dB return loss, 70 dB isolation between channels with an axial ratio better than 0.45 dB. Due to its compact design, it is especially attractive for satellite communications where size and weight are key parameters. We have called this component circumplexer since it is really the junction of circular polarization inside a diplexer.
Simultaneous Doping of Nitrogen and Fluorine into Carbon (NFC) as Metal-Free Oxygen Reduction Electrocatalysts (2017)

Here, we have simply prepared and optimized nitrogen, fluorine co-doped carbon (NFC) as metal-free oxygen reduction reaction (ORR) electrocatalyst from directly pyrolysing the mixture of carbon black and ammonium fluoride. Electrochemical results reveal that pyrolysis temperature plays an essential role on improving the electrocatalytic performance of NFC for the ORR and it reaches the maximum at 900°C, exhibiting the best ORR electrocatalytic activity in terms of the ORR peak potential, onset potential, and half-wave potential. Furthermore, the number of electrons transferred per oxygen molecular is 3.92, the percentage of four-electron is 96.3% and the percentage of peroxide is 3.74% at the disk potential of −0.4 V. Both XRD and Raman indicate that the higher pyrolysis temperature the greater defective nature of NFC. In special, NFC900 has a high portion of mesopores with the BET surface area of 1057 m2/g, and XPS indicates that N and F have been co-doped into the carbon matrix with F mainly in the ionic C-F bond.
High-resolution fluorocarbon-based resist for 157-nm lithography (2002)

Lithography with 157 nm fluorine lasers is rapidly emerging as the next evolutionary step in optical lithography and is clearly seen as the likely successor to 193 nm lithography. In fact, it may become the technology of choice for the sub-100-nm node features. The photoresists used for this technology will be required to be extendable to less than 70 nm. As has been demonstrated with the transition to shorter wavelengths in the past, the photoresist materials that were developed for the longer wavelength applications are too absorbent for practical use as high-resolution single layer resist with 157 nm radiation. This high absorbency will force the coated resist thicknesses to be well under 100 nm. Fluorine containing polymers have been demonstrated to be more transparent in this spectral region than pure hydrocarbon polymers. We have developed and evaluated a number of unique 4-hexafluoroisopropanol styrene based polymer systems which we previously termed FESCAP resists and have developed new acetal partially blocked 4-hexafluoroisopropanol styrene based copolymers. These resists can have absorbencies of under 3 micrometers <SUP>-1</SUP> at 157 nm which could allow imaging to thicknesses of 150 nm. Our recent resist designs are shown to have imaging capability down to 70 nm with a 0.60 NA microstepper.
Towards a [4+2] Route to (+/-)-decarestrictines J and H: Synthesis of a Bicyclic Key-intermediate (2004)

International audience
Social-Aware Replication in Geo-Diverse Online Systems (2014)

Distributing long-tail content is a difficult task due to the low amortization of bandwidth transfer costs as such content has limited number of views. Two recent trends are making this problem harder. First, the increasing popularity of user-generated content and online social networks create and reinforce such popularity distributions. Second, the recent trend of geo-replicating content across multiple points of presence spread around the world, done for improving quality of experience (QoE) for users. In this paper, we analyze and explore the tradeoff involving the “freshness” of the information available to the users and WAN bandwidth costs, and we propose ways to reduce the latter through smart update propagation scheduling, by leveraging on the knowledge of the mapping between social relationships and geographic location, the timing regularities and time differences in end user activity. We first assess the potential of our approach by implementing a simple social-aware scheduling algorithm that operates under bandwidth budget constraints and by quantifying its benefits through a trace-driven analysis. We show that it can reduce WAN traffic by up to 55 percent compared to an immediate update of all replicas, with a minimal effect on information freshness and latency. Second, we build TailGate, a practical system that implements our social-aware scheduling approach, which distributes on the fly long-tail content across PoPs at reduced bandwidth costs by flattening the traffic. We evaluate TailGate by using traces from an OSN and show that it can decrease WAN bandwidth costs by as much as 80 percent and improve QoE. We deploy TailGate on PlanetLab and show that even in the case when imprecise social information is available, it can still decrease by a factor of 2 the latency for accessing long-tail YouTube videos.
LTE for 4G Mobile Broadband (2009)

Do you need to get up to speed quickly on LTE? Understand the new technologies of the LTE standard and how they contribute to improvements in system performance with this practical and valuable guide, written by an expert on LTE who was intimately involved in drafting the standard. In addition to a strong grounding in the technical details, you'll also get fascinating insights into why particular technologies were chosen in the development process. Core topics covered include low-PAPR orthogonal uplink multiple access based on SC-FDMA, MIMO multi-antenna technologies, and inter-cell interference mitigation techniques. Low-latency channel structure and single-frequency network (SFN) broadcast are also discussed in detail. With extensive references, a useful discussion of technologies that were not included in the standard, and end-of-chapter summaries that emphasize all the key points, this book is an essential resource for practitioners in the mobile cellular communications industry and for graduate students studying advanced wireless communications.
The value of pre-symptomatic genetic risk assessment for age-related macular degeneration: the Moran AMD Genetic Testing Assessment (MAGENTA) study—a study protocol for a randomized controlled trial (2023)

ClinicalTrials.gov NCT05265624 . Registered on March 3, 2022.
Uncertainty Estimation in Deep Speech Enhancement Using Complex Gaussian Mixture Models (2022)

Single-channel deep speech enhancement approaches often estimate a single multiplicative mask to extract clean speech without a measure of its accuracy. Instead, in this work, we propose to quantify the uncertainty associated with clean speech estimates in neural network-based speech enhancement. Predictive uncertainty is typically categorized into aleatoric uncertainty and epistemic uncertainty. The former accounts for the inherent uncertainty in data and the latter corresponds to the model uncertainty. Aiming for robust clean speech estimation and efficient predictive uncertainty quantification, we propose to integrate statistical complex Gaussian mixture models (CGMMs) into a deep speech enhancement framework. More specifically, we model the dependency between input and output stochastically by means of a conditional probability density and train a neural network to map the noisy input to the full posterior distribution of clean speech, modeled as a mixture of multiple complex Gaussian components. Experimental results on different datasets show that the proposed algorithm effectively captures predictive uncertainty and that combining powerful statistical models and deep learning also delivers a superior speech enhancement performance.
Autonomous global sky monitoring with real-time robotic follow-up (2008)

We discuss the development of prototypes for a global grid of advanced 'thinking' sky sentinels and robotic follow-up telescopes that observe the full night sky to provide real-time monitoring of the night sky by autonomously recognizing anomalous behavior, selecting targets for detailed investigation, and making real-time anomaly detection to enable rapid recognition and a swift response to transients as they emerge. This T3 global EO grid avoids the limitations imposed by geography and weather to provide persistent monitoring of the night sky.
Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings (2003)

Revertant mosaicism due to true back mutations or second-site mutations has been identified in several inherited disorders. The occurrence of revertants is considered rare, and the underlying genetic mechanisms remain mostly unknown. Here we describe somatic mosaicism in two brothers affected with Wiskott-Aldrich syndrome (WAS). The original mutation causing disease in this family is a single base insertion (1305insG) in the WAS protein (WASP) gene, which results in frameshift and abrogates protein expression. Both patients, however, showed expression of WASP in a fraction of their T cells that were demonstrated to carry a second-site mutation causing the deletion of 19 nucleotides from nucleotide 1299 to 1316. This deletion abrogated the effects of the original mutation and restored the WASP reading frame. In vitro expression studies indicated that mutant protein encoded by the second-site mutation was expressed and functional, since it was able to bind to cellular partners and mediate T cell receptor/CD3 downregulation. These observations were consistent with evidence of in vivo selective advantage of WASP-expressing lymphocytes. Molecular analysis revealed that the sequence surrounding the deletion contained two 4-bp direct repeats and that a hairpin structure could be formed by five GC pairs within the deleted fragment. These findings strongly suggest that slipped mispairing was the cause of this second-site mutation and that selective accumulation of WASP-expressing T lymphocytes led to revertant mosaicism in these patients.
Progress and Challenges Developing a Coating for Next Generation Gravitational-wave Detectors (2007)

The worldwide effort to detect gravitational-waves uses long baseline laser interferometry. The optics in the interferometers use ion-beam deposited multilayer dielectric coatings, for high reflectivity. In addition, the coatings must have very low optical absorption to reduce thermal effects, low mechanical loss and low changes in optical path with temperature to reduce thermal noise. We discuss progress made on developing a suitable coating for the next generation of detectors.
Improved electrical and material characteristics of hafnium titanate multi-metal oxide n-MOSFETs with ultra-thin EOT (~8Å) gate dielectric application (2005)

A novel approach of fabricating laminated TiO/sub 2//HfO/sub 2/ bi-layer multi-metal oxide dielectric was developed for high performance CMOS applications. Both layers showed negligible intermixing and no silicide formation. For the first time, ultra-thin EOT (/spl sim/8 /spl Aring/) was achieved with increased effective permittivity (k /spl sim/ 36) using the bi-layer dielectric. Leakage current characteristic was slightly higher than HfO/sub 2/ due to lower band offset of TiO/sub 2/. However, superior thermal stability (>950/spl deg/C), significantly reduced hysteresis characteristic, and comparable interface state density represent the high quality of TiO/sub 2//HfO/sub 2/ multi-metal oxide. Also, excellent subthreshold swing, increased transconductance, higher current drive, and -33% improved channel electron mobility compared to the control HfO/sub 2/ samples demonstrate the feasibility of new multi-metal oxide application for future CMOS technology.