gebhart/patrepeval huggingface dataset:
Preparation of GDP-L-Fucose by Using Microbial Enzymes (1984)

Journal Article Preparation of GDP-L-Fucose by Using Microbial Enzymes Get access Kenji Yamamoto, Kenji Yamamoto Department of Food Science and Technology, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Takashi Maruyama, Takashi Maruyama Department of Food Science and Technology, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Hidehiko Kumagai, Hidehiko Kumagai Department of Food Science and Technology, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Tatsurokuro Tochikura, Tatsurokuro Tochikura Department of Food Science and Technology, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Taiko Seno, Taiko Seno Department of Food Science and Technology, Kyoto University, Kyoto 606, Japan Osaka Red Cross Blood Center, Jyoto-ku, Osaka 536, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideo Yamaguchi Hideo Yamaguchi Department of Food Science and Technology, Kyoto University, Kyoto 606, Japan Osaka Red Cross Blood Center, Jyoto-ku, Osaka 536, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 48, Issue 3, 1 March 1984, Pages 823–824, https://doi.org/10.1080/00021369.1984.10866226 Published: 01 March 1984 Article history Received: 16 August 1983 Published: 01 March 1984
Basilar branch disease presenting with progressive pure motor stroke (2009)

Although VPI due to basilar branch disease may clinically mimic a classical lacunar syndrome, it is related to a particular pathogenetic mechanism different from microangiopathy or embolism. In contrast to the MRI feature of lacunes, VPI typically extend to the basal surface of the pons. The progressive pattern, ending up in a relative uniform clinical picture, is probably caused by propagating thrombosis.
Broadband microstrip array antennas (2002)

Microstrip antennas and microstrip arrays have several practical features, which could make them interesting candidates for a lot of antenna applications, ranging from mobile communications to phased array radar systems. The required bandwidth of these applications varies from less then a few percent to 30 percent or more for radar applications. Most of the microstrip arrays that have been published in literature are made on electrically thin dielectric materials and are therefore narrow-banded. The bandwidth can be improved if thicker substrates are being used. However, electrically thick substrates give rise to an inductive shift in the input impedance, which means that a good impedance match can only be achieved if a compensating input network is used. A solution for this problem could be the so-called electromagnetically coupled (EMC) microstrip structure. In this case the patches are not physically connected to the feeding coaxial cables. This configuration is shown. The results are presented of a theoretical and experimental study of microstrip array antennas with EMC elements. Mutual coupling between array elements and the input reflection coefficients are investigated and compared with measurements.
Persistent right coronary flow reserve at low perfusion pressure (1989)

To determine whether right coronary (RC) flow reserve persists at perfusion pressures below the apparent autoregulatory range, the RC artery of 18 anesthetized dogs was cannulated and perfused at controlled pressures. RC blood flow (RCBF) fell from 65.3 +/- 6.1 to 33.7 +/- 2.3 ml.min-1.100 g-1 as RC perfusion pressure (RCPP) was reduced from 80 to 40 mmHg. At 40 mmHg, intracoronary adenosine increased RCBF by 97.9 +/- 10.6 ml.min-1.100 g-1 (P less than 0.001). RCBF fell to 9.5 +/- 1.7 ml.min-1.100 g-1 at 20 mmHg, and RCBF did not significantly increase during adenosine, although RC vasodilation was observed in four dogs. Regional right ventricular (RV) blood flows at RCPP of 80 and 40 mmHg were measured by radioactive microsphere technique. Before adenosine infusion, RCBF was distributed uniformly across the RV free wall at normal and low perfusion pressures. During adenosine infusion, blood flow in both regions increased significantly, but the flow reserve was greater in the subendocardial region at both normal and reduced pressures. RV myocardial O2 consumption (MVo2) was decreased significantly at 40 mmHg, however, there was no evidence of ischemia at this pressure, since the RV lactate extraction ratio was normal (n = 8). Thus RV O2 demand fell when RC O2 supply was reduced, although a flow reserve was available. RV MVo2 was restored to normal when right coronary flow reserve was mobilized by adenosine infusion. For RCBF from 65 to 365 ml.min-1.100 g-1, RC venous O2 content rose and RV MVo2 was essentially constant.(ABSTRACT TRUNCATED AT 250 WORDS)
<title>Coding for higher-order partial-response channels</title> (1995)

Partial-response maximum-likelihood (PRML) methods are now being adopted in many digital magnetic recording systems. It is expected that as linear densities continue to increase, there will be a need to use 'extended' PRML techniques. In fact, commercial systems incorporating extended partial-response target channels, denoted EPRML and EEPRML, employing the EPR4 transfer polynomial h(D) equals 1 plus D minus D<SUP>2</SUP> minus D<SUP>3</SUP> and the EEPR4 transfer polynomial h(D) equals 1 plus 2D minus 2D<SUP>3</SUP> minus D<SUP>4</SUP>, respectively, have recently appeared. Among these systems, several apply the rate 2/3, (d,k) equals (1,7) runlength-limited code, originally designed for use with peak-detection, in combination with a detector trellis structure reflecting the d equals 1 constraint. In the EEPR4 case, the d equals 1 constraint is known to provide a coding gain of 2.2 dB, unnormalized for the rate loss, relative to the uncoded channel. In this paper, we describe a nested family of code constraints, properly containing the d equals 1 constraint, intended for use on the EEPR4 channel. These constraints are shown to have the same distance-enhancing properties as the d equals 1 constraint. They permit the design of practical codes for EEPR4 that offer the same coding gain as the (1,7)-coded system, but with higher achievable code rates. The paper concludes with the construction for such a code which, having rate 4/5, offers a 20% increase over the 1,7) code.
Effect of Antiepileptic Drugs on Bone Mineral Density and Bone Metabolism in Epileptic Patients (2004)

Background: Bone mineral density (BMD) is influenced by genetic, hormonal, and environmental factors. Long-term antiepileptic drug (AED) use also causes osteopenia or osteoporosis that have been most extensively described in institutionalized patients. But, the mechanism of these abnormalities is unclear. The objective of this study is to determine the effect of AED on bone density and to explain the pathophysiologic mechanisms by analyzing bone related factors. Methods: We prospectively examined BMD by dual-energy X-ray absorptiometry in 45 patients with epilepsy. We measured the serum calcium, phosphorus, protein, alkaline phosphatase (ALP), bone specific ALP, vitamin D and osteocalcin to analyze the factors that influence bone metabolism. Results: BMD was significantly lower in the patient group than in the control group (p
Improving round-trip time estimates in reliable transport protocols (1991)

article Free AccessImproving round-trip time estimates in reliable transport protocols Authors: Phil Karn Bell Communications Research, Morristown, NJ Bell Communications Research, Morristown, NJView Profile , Craig Partridge Bolt Beranek and Newman, Inc., Cambridge, MA Bolt Beranek and Newman, Inc., Cambridge, MAView Profile Authors Info & Claims ACM Transactions on Computer SystemsVolume 9Issue 4Nov. 1991 pp 364–373https://doi.org/10.1145/118544.118549Published:01 November 1991Publication History 94citation1,450DownloadsMetricsTotal Citations94Total Downloads1,450Last 12 Months87Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
An artificial spiking synapse made of molecules and nanoparticles (2009)

Abstract Molecule-based devices are envisioned to complement silicon devices by providing new functions or already existing functions at a simpler process level and at a lower cost by virtue of their self-organization capabilities, moreover, they are not bound to von Neuman architecture and this may open the way to other architectural paradigms. Here we demonstrate a device made of conjugated molecules and metal nanoparticles (NPs) which behaves as a spiking synapse suitable for integration in neural network architectures. We demonstrate that this device exhibits the main behavior of a biological synapse. These results open the way to rate coding utilization of the NOMFET in perceptron and Hopfield networks. We can also envision the NOMFET as a building block of neuroelectronics for interfacing neurons or neuronal logic devices made from patterned neuronal cultures with solid-state devices and circuits.
Supersensitivity in rat cerebral cortex: pre- and postsynaptic effects of 6-hydroxydopamine at noradrenergic synapses. (1977)

The intraventricular administration of 6-hydroxydopamine resulted in the destruction of noradrenergic nerve terminals in the rat cerebral cortex and a 90% decrease in norepinephrine content. The time courses of the effects of this treatment on catecholamine-stimulated cyclic 39,59-AMP accumulation in slices of cerebral cortex and on beta adrenergic receptors were determined to investigate the mechanisms underlying supersensitivity in this system. The EC50 for norepinephrine stimulation of cyclic AMP accumulation decreased following 6-hydroxydopamine administration. This decrease was apparent within 1 day and was probably due to the loss of the presynaptic uptake system for norepinephrine. The density of beta adrenergic receptors, as determined by measuring the binding of the high-affinity beta adrenergic receptor antagonist [125I]iodohydroxybenzylpindolol, and maximal levels of catecholamine-stimulated cyclic AMP accumulation increased with a slower time course, reaching peak levels approximately 16 days after treatment with 6-hydroxydopamine. The maximal increase in the density of beta adrenergic receptors was 50%, while maximal levels of cyclic AMP accumulation in treated rats were approximately twice those measured in control animals. The KD of [125I]iodohydroxybenzylpindolol for beta adrenergic receptors and the EC50 of isoproterenol for stimulation of cyclic AMP accumulation were unchanged following 6-hydroxydopamine administration, suggesting that the intrinsic properties of the postsynaptic receptor were not affected by denervation. The administration of 6-hydroxydopamine did not affect fluoride-sensitive adenylate cyclase activity. The results are consistent with the idea that the supersensitivity to catecholamines that occurs in the cerebral cortex following 6-hydroxydopamine administration had both pre- and postsynaptic components. The slowly developing postsynaptic component can be at least partially explained by an increase in the density of beta adrenergic receptors.
Amylose, the new perspective in oral drug delivery to the human large intestine (1995)

Research is lacking on the reversibility of antimicrobial resistance (AMR). Thus, we aimed to determine the influence of previous antibiotic use on the development and decay over time of third generation cephalosporin (3GC)-resistance of <i>E. coli</i>. Using the database of hospital laboratories of the Autonomous Province of Bolzano/Bozen (Italy), anonymously linked to the database of outpatient pharmaceutical prescriptions and the hospital discharge record database, this matched case-control study was conducted including as cases all those who have had a positive culture from any site for 3GC resistant <i>E. coli</i> (3GCREC) during a 2016 hospital stay. Data were analyzed by conditional logistic regression. 244 cases were matched to 1553 controls by the date of the first isolate. Male sex (OR 1.49, 95% CI 1.10-2.01), older age (OR 1.11, 95% CI 1.02-1.21), the number of different antibiotics taken in the previous five years (OR 1.20, 95% CI 1.08-1.33), at least one antibiotic prescription in the previous year (OR 1.92, 95% CI 1.36-2.71), and the diagnosis of diabetes (OR 1.57, 95% CI 1.08-2.30) were independent risk factors for 3GCREC colonization/infection. Patients who last received an antibiotic prescription two years or three to five years before hospitalization showed non-significant differences with controls (OR 0.97, 95% CI 0.68-1.38 and OR 0.85, 95% CI 0.59-1.24), compared to an OR of 1.92 (95% CI 1.36-2.71) in those receiving antibiotics in the year preceding hospitalization. The effect of previous antibiotic use on 3GC-resistance of <i>E. coli</i> is highest after greater cumulative exposure to any antibiotic as well as to 3GCs and in the first 12 months after antibiotics are taken and then decreases progressively.
Access to Enantiopure Triarylmethanes and 1,1‐Diarylalkanes by NHC‐Catalyzed Acylative Desymmetrization (2016)

Abstract We present herein an unprecedented, efficient and enantioselective synthesis of triarylmethanes and 1,1‐diarylalkanes through N‐heterocyclic carbene‐catalyzed acylative desymmetrization of bisphenols. This method utilizes readily available substrates, reagents and a simple procedure to deliver the valuable products in excellent enantiopurity. DFT calculations reveal that the selectivity is governed by the C−C bond cleavage step of the tetrahedral intermediate leading to the ester product. A transition state model featuring a combination of intramolecular hydrogen bond and steric effect is developed to explain the enantioselectivity.
Single-Cell Transcriptomics Reveals Heterogeneity and Drug Response of Human Colorectal Cancer Organoids (2018)

Organoids are three-dimensional cell cultures that mimic organ functions and structures. The organoid model has been developed as a versatile in vitro platform for stem cell biology and diseases modeling. Tumor organoids are shown to share ~ 90% of genetic mutations with biopsies from same patients. However, it's not clear whether tumor organoids recapitulate the cellular heterogeneity observed in patient tumors. Here, we used single-cell RNA-Seq to investigate the transcriptomics of tumor organoids derived from human colorectal tumors, and applied machine learning methods to unbiasedly cluster subtypes in tumor organoids. Computational analysis reveals cancer heterogeneity sustained in tumor organoids, and the subtypes in organoids displayed high diversity. Furthermore, we treated the tumor organoids with a first-line cancer drug, Oxaliplatin, and investigated drug response in single-cell scale. Diversity of tumor cell populations in organoids were significantly perturbed by drug treatment. Single-cell analysis detected the depletion of chemosensitive subgroups and emergence of new drug tolerant subgroups after drug treatment. Our study suggests that the organoid model is capable of recapitulating clinical heterogeneity and its evolution in response to chemotherapy.
Nitric Acid Oxidation of Dixylylethane to Benzophenone Tetracarboxylic Acid (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitric Acid Oxidation of Dixylylethane to Benzophenone Tetracarboxylic AcidJohann G. D. Schulz and Anatoli OnopchenkoCite this: Ind. Eng. Chem. Prod. Res. Dev. 1976, 15, 2, 152–156Publication Date (Print):June 1, 1976Publication History Published online1 May 2002Published inissue 1 June 1976https://pubs.acs.org/doi/10.1021/i360058a010https://doi.org/10.1021/i360058a010research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Modifying Surface Structure to Tune Surface Properties of Vertically Aligned Carbon Nanotube Films (2010)

We report a simple etching process to modify surface of vertically aligned carbon nanotube (VACNT) arrays for their applications in superhydrophobic surface, field emission display, and sun energy conversion, etc. At a high temperature (700-800 degrees C), very low concentration water vapor in presence with Ar and hydrogen flow can be a weak oxidant, and mildly etch nanotube tips without damaging their walls. This process can be performed right after the CNT growth process. Surface of nanotube arrays becomes multi-tiered nanotube patterns with open-ended nanotubes standing straightly. Surface morphology of nanotube arrays can be tuned by changing the etching time. Water droplets on a modified nanotube surface show a large contact angle and sliding angle, which make the etched nanotube film suitable for application such as small amount liquid transport. Light absorption measurement indicated that surface roughness has no effect to improve the light absorption, indicating a different mechanism from other black material. The surface modified nanotube arrays have much increased field enhancement factor in our field emission test, showing the better field emission ability of the nanotube arrays with open tips.
A new clinically relevant method of calculating adherence (2015)

Currently calculating adherence is based on pill counting which tends to overestimate and can only present adherence as a percentage of total consumption with no information on pattern or potential reasons of non-adherence. We hypothesize a method of calculating adherence, area under the curve (AUC), will be more reflective of drug consumption and correlate better with clinical parameters. In the studies used for this analysis, patients were given an acoustic electronic adherence monitor INCA<sup>TM</sup> attached to a salmeterol/fluticasone inhaler to measure adherence one month at a time. The AUC was calculated using the trapezoid function We calculated the dose counter rate (Dc) attempted rate (At, patient attempting to take their inhaler) and the actual rate (Ac, accounting for technique errors). This method was developed on 30 patients and validated in more than a 100 patients from different patient cohorts, COPD, Asthma &amp; Community Care. At 1 month there was a significant difference in At and Ac rates (71%, 47% respectively) and Dc (85%) and Ac, p&lt;0.001. Looking at clinical parameters over 3 months 56% of patients with a significant fall in AQLQ had an Ac &lt;80%. With the Dc, 70% of patients with a fall in AQLQ had a Dc &gt; than 80%. Similarly, patients who had &gt; 2 exacerbations in the prior year had a Dc of 85%, and an Ac of 45%. (p&lt;0.001). Looking at asthma control (ACT) at 3 months, the mean Dc of uncontrolled patients (ACT&lt;19) was 88%, and the Ac was 67%. (p&lt;0.001). Finally looking at reliever use, patients who used their reliever every day had a Dc of 94% and an Ac of 75% (p=0.001) We have developed a new method of calculating adherence from data collected by a novel electronic monitor that correlates well with clinical measures.
Educational Objectives Of Different Laboratory Types: A Comparative Study (2009)

Laboratory based courses play a critical role in scientific education. Automation is changing the nature of the laboratories, and there is a long running debate about the value of hands on versus simulated and remote laboratories. The remote lab technology has brought a significant improvement in communication within the Academic community and has improved students learning experiences. There are different educational objectives as criteria for judging the laboratories: Hands on advocates emphasize design skills, while remote lab advocates focus on conceptual understanding. Remote laboratories offer all the advantages of the new technology, but are often a poor replacement for real laboratory work. Remote laboratories are similar to simulation techniques in that they require minimal space and time, because the experiments can be rapidly configured and run over the Internet [Web]. But unlike simulations, they provide real data. This paper presents a comparative analysis for the educational objectives of the three laboratory techniques, hands on, simulated, and remote laboratories. In addition, it proposes enhancements for the remote lab activities leading to improving its performance.
Carrier Transport in Dye-sensitized ZnO and TiO2 Nanoparticles: What Can We Learn from Ultrafast Terahertz Spectra? (2010)

We used time-resolved spectroscopies in terahertz and visible ranges complemented with Monte-Carlo simulations to assess the connection between ultrafast charge injection and formation and transport of mobile charge carriers in dye-sensitized nano-structured semiconductors.
Intranasal Carbetocin Reduces Hyperphagia, Anxiousness, and Distress in Prader-Willi Syndrome: CARE-PWS Phase 3 Trial (2023)

NCT03649477.