gebhart/patrepeval huggingface dataset:
Structure-functional property relationships in rf-sputtered vanadium dioxide thin films (2007)

The study of metal-insulator transition (MIT) in VO2 thin films synthesized by means of rf sputtering from a VO2 target is presented. A comparison with conventional reactive sputtering from a V target is also given. Detailed x-ray diffraction analysis, electrical resistance switching, and infrared optical reflectance measurements confirm that our sputtering technique yields high-quality VO2 films. We discuss in depth how synthesis conditions affect MIT parameters derived from temperature dependence of electrical resistance. Sharp MIT is observed in films sputtered on technologically important Si substrates. The choice of Si (or sapphire) substrates results in the transition temperature above (below) the values obtained for single VO2 crystals. The MIT becomes narrower and stronger in thinner films. This is consistent with the assumption that the increased width of the MIT in thin films with respect to single crystals is the result of averaging of the transition parameters over a distribution of crystallites in the film. The measurements of MIT in VO2 patterned into devices do not reveal a noticeable lateral size effect down to 20 μm devices, encouraging use of the phase transition in switching electronic devices. The effect of substrate temperature and ambient during the sputtering on MIT is discussed. While VO2 films are found to be stable in ambient environment with time, the additional exposure to UV radiation near room temperature is shown to enhance the oxidation kinetics and produce changes in film resistance. Using UV radiation as an additional tool to control the oxidation process during VO2 synthesis may allow the synthesis temperature to be lowered and an improvement in material quality. We anticipate these results may be of relevance to synthesizing functional oxide films with potential applications in electronics and sensors.
InAs/InAsSb Type-II Superlattice Mid-Wavelength Infrared Focal Plane Array With Significantly Higher Operating Temperature Than InSb (2018)

We report focal plane array (FPA) results on a mid-wavelength InAs/InAsSb type-II strained layer superlattice (T2SLS) unipolar barrier infrared detector with a cutoff wavelength of 5.4 μm. For 300 K background in the 3-5-μm band, f/2 aperture, an FPA operating at 150 K exhibits a mean noise equivalent differential temperature (NEDT) of 18.5 mK, and an NEDT operability of 99.7%. The NEΔT distribution has a width of 8 mK, with no noticeable distribution tail, indicating excellent uniformity. The mean noise-equivalent irradiance is 9.1 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> photons/sec-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The mean quantum efficiency is 49.1% without antireflection coating, and the mean specific detectivity (D <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">*</sup> ) is 2.53 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> cm-Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">½</sup> /W. Benefitting from an absorber material with a much longer Shockley-Read-Hall minority carrier lifetime, and a device architecture that suppresses generation-recombination and surface-leakage dark current, the InAs/InAsSb T2SLS barrier infrared detector FPA has demonstrated a significantly higher operating temperature than the mid-wavelength infrared market-leading InSb.
Reconstruction of sparse signals from distorted randomized measurements (2010)

In this paper we show that, surprisingly, it is possible to recover sparse signals from nonlinearly distorted measurements, even if the nonlinearity is unknown. Assuming just that the nonlinearity is monotonic, we use the only reliable information in the distorted measurements: their ordering. We demonstrate that this information is sufficient to recover the signal with high precision and present two approaches to do so. The first uses order statistics to compute the minimum mean square (MMSE) estimate of the undistorted measurements and use it with standard compressive sensing (CS) reconstruction algorithms. The second uses the principle of consistent reconstruction to develop a deterministic nonlinear reconstruction algorithm that ensures that measurements of the reconstructed signal have ordering consistent with the ordering of the distorted measurements. Our experiments demonstrate the superior performance of both approaches compared to standard CS methods.
Cable Overvoltage for Mmc Based Vsc Hvdc System: Interaction with Converters (2018)

MMC (Modular Multilevel Converter) type Voltage Source Converter (VSC) based High Voltage Direct Current (HVDC) transmission system often uses cables as DC power transmission medium. One potential challenge faced by the cable system is new type of OVs (overvoltages) occurring in the dc cable due to faults in the HVDC system depending on system topology and converter design. The cable generally needs to be designed to withstand the voltage occurring during a fault, which makes it important to find the highest possible OV appearing in the cable of various transmission system designs.
3931 Drive-by-Wire System of Micro Electric Vehicle by Utilizing Road Image Information (2005)

This paper examines the feasibility of drive-by-wire system of electric vehicle in the context of lane keeping system. The drive-by-wire, which is designed to generate differential traction force distribution, induces direct yaw moment about center of gravity to assist the driver steering maneuver for lane keeping task. Consequently, the controller is designed to regulate the lateral deviation based on the lane marker position acquired via CCD camera with on-board image processing system. The effectiveness of the proposed control system was verified by actual driving test with micro-scale electric vehicle equipped with two independent in-wheel-motors.
Signal processing and discriminating techniques incorporated in a protective scheme based on travelling waves (1989)

The incorporation of correlation techniques in a protective scheme based on travelling waves is described and it is shown that important features of signals arriving at the relaying point can be extracted, even from complex waveforms, using correlation techniques. The influence of window length on detection accuracy is also investigated. The results are used in a protective algorithm, previously described by the authors, to obtain reliable relaying information. A method for dealing with close-up faults is also presented together with a range of results showing the discriminating ability of the algorithm.
Blockade of LH Release and Ovulation in the Rabbit with Inhibitory Analogues of Luteinizing Hormone Releasing Hormone1 (1977)

Plasma LH levels and ovulation were studied in female rabbits following administration of several inhibitory analogues of luteinizing hormone-releasing hormone (LHRH) before and after mating with experienced males. Administration of (D-Phe2, D-Leu6)-LHRH (1.5 mg/kg sc) to does 30 min before mating did not prevent either LH release or ovulation. However, a single sc injection of (D-Phe2, L-Phe3, D-Phe6y-LHRH (6 mg/kg) given 30 min before mating in 4 rabbits resulted in a 30-60 min delay in the coitus-induced release of LH when compared with post-coital changes in the same animals injected with vehicle; however, all of the does ovulated. When multiple dosages of 4 mg/kg (D-Phe2, L-Phe3, D-Phe6)-LHRH were administered 3-5 times at half-hourly intervals beginning 30 min prior to mating there was a considerable reduction in plasma LH elevations at 0.5, 1.0, 2.0 and 4.0 h after mating and 3/5 treated rabbits showed partial or complete blockade of ovulation. Quite similar results were obtained with the same dosage of (D-Phe2, D-Trp3, D-Phe6)-LHRH. An early sharp peak in LH release and full ovulation were stimulated in 6 out of 6 does by a single iv injection of synthetic LHRH (500 ng/kg). However, in another experiment, three half-hourly sc injections (4 mg/kg) of (D-Phe2, L-Phe3, D-Phe6)-LHRH beginning 30 min before administering LHRH markedly reduced the rise in plasma LH (P less than 0.01) and completely blocked ovulation in all of the same 6 animals. An unsuccessful attempt was made to provide a test animal for LHRH analogue investigations by implanting 4 cm of silastic tubing filled with crystalline estradiol (E2) sc in ovariectomized (OVX) AND INTACT DOES. In OVX does the silastic E2 implants resulted in a progressive decline in the ability to release LH in response to mating at 6 and at 20 days after implantation. With ovaries present, the E2 implant permitted post-coital LH release and ovulation at 4 d but not at 30 d post-implantation. At 30 d after removal of the E2 implant three out of four does had fully recovered the ability to release LH and ovulate post-coitally. Collectively, these results indicate that inhibitory analogues of LHRH can effectively block the ovulatory response to exogenous LHRH in rabbits, but that coitally-induced LH release and ovulation are less susceptible to blockade by the analogues. Silastic E2 implants, however, progressively and reversibly reduce the capacity of does to release LH after mating.
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding (2007)

The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram-negative bacteria and a promising antibiotic target. CHIR-090, the most potent LpxC inhibitor discovered to date, displays two-step time-dependent inhibition and kills a wide range of Gram-negative pathogens as effectively as ciprofloxacin or tobramycin. In this study, we report the solution structure of the LpxC-CHIR-090 complex. CHIR-090 exploits conserved features of LpxC that are critical for catalysis, including the hydrophobic passage and essential active-site residues. CHIR-090 is adjacent to, but does not occupy, the UDP-binding pocket of LpxC, suggesting that a fragment-based approach may facilitate further optimization of LpxC inhibitors. Additionally, we identified key residues in the Insert II hydrophobic passage that modulate time-dependent inhibition and CHIR-090 resistance. CHIR-090 shares a similar, although previously unrecognized, chemical scaffold with other small-molecule antibiotics such as L-161,240 targeting LpxC, and provides a template for understanding the binding mode of these inhibitors. Consistent with this model, we provide evidence that L-161,240 also occupies the hydrophobic passage.
CD71 is Selectively and Ubiquitously Expressed at High Levels in Erythroid Precursors of All Maturation Stages (2011)

Histology assessment of erythroid precursors in bone marrow biopsies can be challenging under pathologic conditions and often requires ancillary studies. CD71 (transferring receptor-1) is known to be expressed in the earliest erythroid precursors, and has been useful for flow cytometry. However, CD71 is also regarded as a proliferation marker, and its lineage specificity has not been systemically investigated by immunohistochemistry in detail. In this study, we found that CD71 was strongly expressed in all erythroid precursors in normal and dyspoietic marrows. Staining of CD71 effectively highlighted pronormoblasts in all 4 cases of parvovirus infection and erythroblasts in all 6 cases of acute erythroleukemia, for which staining of glycophorin A and hemoglobin A was either absent or unreliable. CD71 was absent in the background mature red blood cells in general, nonerythroid elements in the normal marrow, myeloid precursors in myeloproliferative disorders, and blasts in nearly all acute myeloid leukemia encompassing all common French-American-British subtypes. Benign lymphoid infiltrates and low-grade lymphomas involving the marrow also lacked detectable CD71. Although weak CD71 expression was found in acute lymphoblastic leukemia, diffuse large B-cell lymphoma, and 1 of 2 cases of acute megakaryoblastic leukemia, it had little impact on interpretation due to a high signal-to-noise ratio of the staining intensities when compared with erythroid precursors in the same section. We conclude that CD71 is selectively expressed at high levels in erythroid precursors, including those at early maturation stages. It can be reliably used as an independent erythroid marker for immunohistochemical analysis of the marrow.
Data from Radiation-Induced Caspase-8 Mediates p53-Independent Apoptosis in Glioma Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Malignant gliomas are almost uniformly fatal and display exquisite radiation resistance. Glioma cells lacking wild-type (WT) p53 function are more susceptible to radiation-induced apoptosis than their isogenic counterparts expressing WT p53. We explored the mechanisms of such apoptosis and found that, in the absence of WT p53, radiation increases caspase-8 expression and activity. Inhibition of caspase-8 expression using caspase-8 antisense or small interfering RNA (siRNA) oligonucleotides partially blocks radiation-induced apoptosis. In contrast, inhibition of the mitochondrial death pathway by expression of Bcl-2 has no effect on radiation-induced caspase-8 activity or apoptosis. Our data indicate that, in contrast to commonly accepted models of p53-dependent radiation-induced apoptosis, in our cell system, radiation relies on caspase-8 activity to help mediate p53-independent cell death. In a system of inducible E2F1 activity, E2F1 activated caspase-8 and, accordingly, decreased cellular viability, effects that were abolished by caspase-8 siRNA. In this model, in the absence of WT p53, p21&lt;sup&gt;Cip1&lt;/sup&gt; is not induced, and E2F1 activity is sustained and allows transcription and activation of caspase-8. This model may explain why p53 mutations in adult gliomas paradoxically correlate with improved survival and enhanced response to radiation. (Cancer Res 2006; 66(8): 4223-32)&lt;/p&gt;&lt;/div&gt;
New Model of Permeability of Tight Shale Gas Rock Based on Open-System Geomechanics (2013)

Finding an adequate description of permeability in shale gas is a challenging problem because of complexity of the rock which contains both organic and non-organic components. Due to small pore size, which is comparable with the mean free path of molecular motion, matrix permeability should include Knudsen and slip flow components as well as conventional Poiseuille one. If we assume as usual that permeability is a function of porosity, k(φ), then stress and pore pressure dependence of variation of permeability can be found as determined by porosity related effective (Terzaghi) stress, i.e. difference between confining stress and pore pressure (Carroll, 1980; Charlez, 1997)
Microvascular responses in rabbit skeletal muscle after fixed volume hemorrhage (1990)

The effect of hemorrhage on the microvascular responses in the tenuissimus muscle was studied by means of intravital microscopy in rabbits anesthetized with urethan. The rabbits were bled 30% of their calculated blood volume within 3 min. Hemorrhage initially caused mean arterial pressure to drop from 70 +/- 7 to 26 +/- 5 mmHg. During the subsequent 30-min observation period it increased to 43 +/- 8 mmHg. The transverse arterioles (TRs), supplying both muscle tissue proper and adjacent connective tissue, gradually constricted to 75% of control over the 30-min period. Terminal arterioles (TEs) branching from the TR in the muscle tissue constricted to 65% in 10 min and then gradually relaxed, eventually reaching 80% of control diameter. The constriction of the TEs was confined to a short sphincterlike structure (10-20 microns) at the origin of the bifurcation. Upon constriction, the diameter of the sphincterlike structure was less than the critical diameter for erythrocyte passage. Given that the effective blood viscosity in the narrow TE is strongly dependent on luminal diameter, the overall effect on blood flow and its distribution in the tenuissimus muscle was a dramatic reduction of volume flow to 20-30% of the control value. During the early phase, the reduced flow was diverted to the connective tissue at the expense of nutrient flow to the muscle tissue. This early blood flow pattern gradually reversed, partially restoring nutrient flow to the muscle fibers.
JAAOS at 25 Years (2017)

Dr. Levine is Editor-in-Chief of the Journal of the American Academy of Orthopaedic Surgeons, Rosemont, IL, and the Frank E. Stinchfield Professor and Chairman, Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY. Dr. Levine or an immediate family member serves as an unpaid consultant to Zimmer Biomet.
Quantitative analysis of vitamin D and its main metabolites in human milk by supercritical fluid chromatography coupled to tandem mass spectrometry (2019)

A novel method to quantitate vitamin D and its main metabolites (vitamin D3, vitamin D2, and their 25-hydroxy metabolites) in breast milk by supercritical fluid chromatography has been developed and fully validated. A small volume of sample (1 mL) is subjected to ethanolic protein precipitation and liquid-liquid extraction. Final extracts are derivatized with 4-phenyl-1,2,4-triazoline-3,5-dione and vitamin D derivatives analyzed by supercritical fluid chromatography hyphenated to tandem mass spectrometry with atmospheric pressure chemical ionization. Multiple reaction monitoring is used for quantitation. Separation conditions were optimized using a gradient of methanol-water-ammonium formate into carbon dioxide. Make-up solvent was methanol containing ammonium formate. The quantitation limit reached levels as low as 50 pmol/L, with intra- and inter-day relative standard deviations lower than 15% and 20% for all analytes. Accuracy was evaluated by spiking experiments and was well within acceptability ratios (± 15%). The method was then applied to a subset of commercially available human milk samples. The newly developed method provides opportunities to determine the nutritional status of mother-infant dyads from a non-invasive measure, or for interventional or observational studies building knowledge on the composition of human milk. Graphical abstract.
#MeTooMA: Multi-Aspect Annotations of Tweets Related to the MeToo\n Movement (2019)

In this paper, we present a dataset containing 9,973 tweets related to the\nMeToo movement that were manually annotated for five different linguistic\naspects: relevance, stance, hate speech, sarcasm, and dialogue acts. We present\na detailed account of the data collection and annotation processes. The\nannotations have a very high inter-annotator agreement (0.79 to 0.93 k-alpha)\ndue to the domain expertise of the annotators and clear annotation\ninstructions. We analyze the data in terms of geographical distribution, label\ncorrelations, and keywords. Lastly, we present some potential use cases of this\ndataset. We expect this dataset would be of great interest to psycholinguists,\nsocio-linguists, and computational linguists to study the discursive space of\ndigitally mobilized social movements on sensitive issues like sexual\nharassment.\n
Sensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populations (2009)

Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of applications from disease mapping to learning about history. Most methods require the use of unlinked markers; but, using all markers from genome-wide scanning arrays, it should in principle be possible to infer the ancestry of even very small segments with exquisite accuracy. We describe a method, HAPMIX, which employs an explicit population genetic model to perform such local ancestry inference based on fine-scale variation data. We show that HAPMIX outperforms other methods, and we explore its utility for inferring ancestry, learning about ancestral populations, and inferring dates of admixture. We validate the method empirically by applying it to populations that have experienced recent and ancient admixture: 935 African Americans from the United States and 29 Mozabites from North Africa. HAPMIX will be of particular utility for mapping disease genes in recently admixed populations, as its accurate estimates of local ancestry permit admixture and case-control association signals to be combined, enabling more powerful tests of association than with either signal alone.
Slow Dynamics in Folded and Unfolded States of an SH3 Domain (2001)

(15)N relaxation dispersion experiments were applied to the isolated N-terminal SH3 domain of the Drosophila protein drk (drkN SH3) to study microsecond to second time scale exchange processes. The drkN SH3 domain exists in equilibrium between folded (F(exch)) and unfolded (U(exch)) states under nondenaturing conditions in a ratio of 2:1 at 20 degrees C, with an average exchange rate constant, k(ex), of 2.2 s(-1) (slow exchange on the NMR chemical shift time scale). Consequently a discrete set of resonances is observed for each state in NMR spectra. Within the U(exch) ensemble there is a contiguous stretch of residues undergoing conformational exchange on a micros/ms time scale, likely due to local, non-native hydrophobic collapse. For these residues both the F(exch) <--> U(exch) conformational exchange process and the micros/ms exchange event within the U(exch) state contribute to the (15)N line width and can be analyzed using CPMG-based (15)N relaxation dispersion measurements. The contribution of both processes to the apparent relaxation rate can be deconvoluted numerically by combining the experimental (15)N relaxation dispersion data with results from an (15)N longitudinal relaxation experiment that accurately quantifies exchange rates in slow exchanging systems (Farrow, N. A.; Zhang, O.; Forman-Kay, J. D.; Kay, L. E. J. Biomol. NMR 1994, 4, 727-734). A simple, generally applicable analytical expression for the dependence of the effective transverse relaxation rate constant on the pulse spacing in CPMG experiments has been derived for a two-state exchange process in the slow exchange limit, which can be used to fit the experimental data on the global folding/unfolding transition. The results illustrate that relaxation dispersion experiments provide an extremely sensitive tool to probe conformational exchange processes in unfolded states and to obtain information on the free energy landscape of such systems.