gebhart/patrepeval huggingface dataset:
Multisensory visual–tactile object related network in humans: insights gained using a novel crossmodal adaptation approach (2009)

Neuroimaging techniques have provided ample evidence for multisensory integration in humans. However, it is not clear whether this integration occurs at the neuronal level or whether it reflects areal convergence without such integration. To examine this issue as regards visuo-tactile object integration we used the repetition suppression effect, also known as the fMRI-based adaptation paradigm (fMR-A). Under some assumptions, fMR-A can tag specific neuronal populations within an area and investigate their characteristics. This technique has been used extensively in unisensory studies. Here we applied it for the first time to study multisensory integration and identified a network of occipital (LOtv and calcarine sulcus), parietal (aIPS), and prefrontal (precentral sulcus and the insula) areas all showing a clear crossmodal repetition suppression effect. These results provide a crucial first insight into the neuronal basis of visuo-haptic integration of objects in humans and highlight the power of using fMR-A to study multisensory integration using non-invasinve neuroimaging techniques.
Simple theory for correction of marine vibroseis phase dispersion (1989)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1989Simple theory for correction of marine vibroseis phase dispersionAuthors: Philip S. SchultzAndrew W. PieprzakGraham R. JohnsonLeon WalkerPhilip S. SchultzGECO Geophysical Co., England, Andrew W. PieprzakGECO Geophysical Co. Inc. (US), Graham R. JohnsonGECO Geophysical Co. Inc. (US), and Leon WalkerGECO Geophysical Co. Inc. (US)https://doi.org/10.1190/1.1889560 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1889560FiguresReferencesRelatedDetailsCited ByThe effects of source and receiver motion on seismic data1Geophysical Prospecting, Vol. 43, No. 2 SEG Technical Program Expanded Abstracts 1989ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1989 Pages: 1375 publication data© 1989 Copyright © 1989 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Philip S. Schultz, Andrew W. Pieprzak, Graham R. Johnson, and Leon Walker, (1989), "Simple theory for correction of marine vibroseis phase dispersion," SEG Technical Program Expanded Abstracts : 660-662. https://doi.org/10.1190/1.1889560 Plain-Language Summary PDF DownloadLoading ...
Using Chemoattractants to Lure Bacteria to Contact‐Killing Surfaces (2016)

Abstract Antimicrobial surfaces with covalently attached biocidal functionalities only kill microbes that come into direct contact with the surfaces (contact‐killing surfaces). Herein, the activity of contact‐killing surfaces is shown to be enhanced by using gradients in the concentration of soluble chemoattractants (CAs) to attract bacteria to the surfaces. Two natural and nonbiocidal CAs (aspartate and glucose) were used to attract bacteria to model surfaces decorated with quaternary ammonium groups (known to kill bacteria that come into contact with them). These results demonstrate the killing of Escherichia coli and Salmonella typhimurium , two common pathogens, at levels 10‐ to 20‐times greater than that of the native surfaces alone. This approach is general and provides new strategies for the design of active or dynamic contact‐killing surfaces with enhanced antimicrobial activities.
Intercalation of Natural Cyclodextrins into Layered Double Hydroxide by Calcination–Rehydration Reaction (2005)

Abstract Natural α-, β-, and γ-cyclodextrins (CDs) were intercalated in the interlayer of layered double hydroxide (LDH) by calcination–rehydration reaction using the calcined precursor of Mg–Al/CO3/LDH. The intercalated amount was considerably large in spite of nonanionic macrocyclic molecule in the wide CD concentration range. The presence of hydroxyl group on upper and lower rim in CD molecule favors the intercalation driving force by hydrogen bond with the hydroxide basal layer. In addition, CDs in the CD/LDHs were deintercalated by the ion exchange with carbonate ion with regeneration of the pristine Mg–Al/CO3/LDH.
Production of lesions in gnotobiotic mice by inoculation with Treponema hyodysenteriae (1981)

Treponema hyodysenteriae was established in the ceca of gnotobiotic mice in the absence of other organisms. Superficial mucosal lesions characteristic of swine dysentery were present in the ceca of mice inoculated with T. hyodysenteriae in combination with viable Bacteroides vulgatus. Deep crypt necrosis was detected in the ceca of mice inoculated with T. hyodysenteriae alone.
Visual Programming in a Visual Domain: A Case Study of Cognitive Dimensions (2010)

We present a new visual programming language and environment that serves as a form of feedback and representation in a Programming by Demonstration system. The language differs from existing visual languages because it explicitly represents data objects and implicitly represents operations by changes in data objects. The system was designed to provide non-programmers with programming support for common, repetitive tasks and incorporates some principles of cognition to assist these users in learning to use it. With this in mind, we analyzed the language and its editor along cognitive dimensions. The assessment provided insight into both strengths and weaknesses of the system, prompting a number of design changes. This demonstrates how useful such an analysis can be.
Base‐Catalyzed Domino Reaction Between Aldoxime and N‐Chlorosuccinimide in Alcohol: One‐Pot Synthesis of Alkyl 3‐(3‐Aryl‐1,2,4‐oxadiazol‐5‐yl)propanoates (2022)

Abstract A method for preparation of alkyl 3‐aryl‐(1,2,4‐oxadiazol‐5‐yl)propanoates by base‐catalyzed domino reaction of an aryl aldoxime with N ‐chlorosuccinimide in alcohol is described. In this reaction, initially aldoxime and N ‐chlorosuccinimide react to produce hydroximidoyl chloride and succinimide. The hydroximidoyl chloride and base produces nitrile oxide which undergoes [3+2] annulation with succinimide followed by ring opening reaction with the assistance of alcohol to give alkyl 3‐aryl‐(1,2,4‐oxadiazol‐5‐yl)propanoates in 65–95% yield. magnified image
Rapid identification of 11 human intestinalLactobacillusspecies by multiplex PCR assays using group- and species-specific primers derived from the 16Sâ23S rRNA intergenic spacer region and its flanking 23S rRNA (2000)

Rapid and reliable two-step multiplex polymerase chain reaction (PCR) assays were established to identify human intestinal lactobacilli; a multiplex PCR was used for grouping of lactobacilli with a mixture of group-specific primers followed by four multiplex PCR assays with four sorts of species-specific primer mixtures for identification at the species level. Primers used were designed from nucleotide sequences of the 16S-23S rRNA intergenic spacer region and its flanking 23S rRNA gene of members of the genus Lactobacillus which are commonly isolated from human stool specimens: Lactobacillus acidophilus, Lactobacillus crispatus, Lactobacillus delbrueckii (ssp. bulgaricus and ssp. lactis), Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus jensenii, Lactobacillus paracasei (ssp. paracasei and ssp. tolerans), Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus and Lactobacillus salivarius (ssp. salicinius and ssp. salivarius). The established two-step multiplex PCR assays were applied to the identification of 84 Lactobacillus strains isolated from human stool specimens and the PCR results were consistent with the results from the DNA-DNA hybridization assay. These results suggest that the multiplex PCR system established in this study is a simple, rapid and reliable method for the identification of common Lactobacillus isolates from human stool samples.
Controlled-source Elastodynamic Interferometry by Cross-correlation of Decomposed Wavefields (2009)

Controlled-source interferometry can be applied to redatum source locations to downhole receiver locations by cross-correlation and summation over sources. The methodology does not require a velocity model between sources and receivers. Starting with a re
Geometric superresolution and field-of-view extension achieved using digital mirror devices (2013)

Superresolving configurations that integrate two digital mirror devices (DMDs) in the aperture and/or in the intermediate image plane are presented. The usage of DMDs allows obtaining geometric resolution improvement, enhancing field of view (FOV), and reducing aberrations such as defocusing and blurring (obtained due to relative movement during the integration time of the camera). The idea behind all the above-mentioned applications is to use the DMDs to properly encode the space and the spatial frequency domains such that the object’s information can be separated from the above mentioned aberrations, distortions, limitations, and noises. The compressed sensing concept is applied in order to allow capturing in time-less images than the obtainable improvement factor (of resolution, of FOV, or of aberration correction).
Analysis and synthesis of facial expressions with hand-generated muscle actuation basis (2002)

We present a performance-driven facial animation system for analyzing captured expressions to find muscle actuation and synthesizing expressions with the actuation values. A significantly different approach of our work is that we let artists sculpt the initial draft of the actuation basis: the basic facial shapes corresponding to the isolated actuation of individual muscles, instead of calculating skin surface deformation entirely, relying on mathematical models such as finite element methods. We synthesize expressions by linear combinations of the basis elements, and analyze expressions by finding the weights for the combinations. Even though the hand-generated actuation basis represents the essence of the subject's characteristic expressions, it is not accurate enough to be used in the subsequent computational procedures. We also describe an iterative algorithm to increase the accuracy of the actuation basis. The experimental results suggest that our artist-in-the-loop method produces a more predictable and controllable outcome than pure mathematical models, and thus can be a quite useful tool in animation productions.
Production of quorum-sensing-related signal molecules by epiphytic bacteria inhabiting wheat heads (2006)

The production of quorum-sensing-related signal molecules (QSRMs) among culturable bacteria comprising the community on wheat heads was investigated. The taxonomic position of 186 bacterial isolates obtained from ten heads was inferred based on 16S rRNA gene sequences, and their QSRM production was determined using two bioreporter strains of N-acylhomoserine lactones. Approximately 33% of isolates produced QSRMs, though the proportion of QSRM-producing isolates on a wheat head was significantly negatively correlated with population size. Most of the producing isolates were Pantoea species, most commonly Pantoea ananatis. Furthermore, the proportion of Pantoea ananatis that produced QSRMs was significantly negatively correlated with the number of bacterial genera (community richness) on each head. Finally, community richness was positively correlated with population size. Qualitative analysis using thin-layer-chromatography revealed that the QSRMs of Pantoea isolates were composed of at least two compounds. This is the first report indicating that Pantoea ananatis isolates inhabiting wheat heads are capable of producing QSRMs. QSRM production by Pantoea spp. may contribute to the predominance of this genus on wheat heads, particularly at relatively low population densities and community diversity.
Monolithic CMOS-MEMS integration for high-g accelerometers (2014)

This paper highlights work-in-progress towards the conceptualization, simulation, fabrication and initial testing of a silicon-germanium (SiGe) integrated CMOS-MEMS high-g accelerometer for military, munition, fuze and shock measurement applications. Developed on IMEC’s SiGe MEMS platform, the MEMS offers a dynamic range of 5,000 g and a bandwidth of 12 kHz. The low noise readout circuit adopts a chopper-stabilization technique implementing the CMOS through the TSMC 0.18 µm process. The device structure employs a fully differential split comb-drive set up with two sets of stators and a rotor all driven separately. Dummy structures acting as protective over-range stops were designed to protect the active components when under impacts well above the designed dynamic range.
The Influence of Hydrogen and Hydrophobic Bonds on the Stability of the Carboxylic Acid Dimers in Aqueous Solution (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Influence of Hydrogen and Hydrophobic Bonds on the Stability of the Carboxylic Acid Dimers in Aqueous SolutionEugene E. Schrier, Marcia. Pottle, and Harold A. ScheragaCite this: J. Am. Chem. Soc. 1964, 86, 17, 3444–3449Publication Date (Print):September 1, 1964Publication History Published online1 May 2002Published inissue 1 September 1964https://pubs.acs.org/doi/10.1021/ja01071a009https://doi.org/10.1021/ja01071a009research-articleACS PublicationsRequest reuse permissionsArticle Views614Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Facile Synthesis of BaTiO3 Nanocubes with the Use of Anatase TiO2 Nanorods as a Precursor to Titanium Hydroxide (2016)

Abstract We report a solvothermal method for the facile and reproducible synthesis of BaTiO 3 nanocubes by employing anatase TiO 2 nanorods as a precursor to titanium hydroxide. The TiO 2 nanorods were, in turn, synthesized in advance through another solvothermal process. We could obtain high‐quality BaTiO 3 nanocubes by reacting the TiO 2 nanorods with Ba(NO 3 ) 2 under solvothermal conditions in the presence of oleic acid and acetic acid as dual capping agents, followed by a purification process involving chemical washing and physical filtration. The addition of acetic acid alongside oleic acid was critical to the formation of well‐defined {100} facets on the nanocrystals and also increased batch‐to‐batch reproducibility without the use of a glove box or similar air‐free experimental design. Using this method, BaTiO 3 nanocubes crystallized in the cubic phase could be readily obtained with an average edge length around 8 nm.
Detection of multiple extracytoplasmic function (ECF) sigma factors in the genome of Pseudomonas putida KT2440 and their counterparts in Pseudomonas aeruginosa PA01 (2002)

Pseudomonas putida KT2440 is highly successful in colonizing a variety habitats, including aquatic and edaphic niches. In accordance with this ability and with the need to adapt to changing environmental conditions, P. putida has developed sophisticated mechanisms of transcriptional regulation. We analysed, at the genome level, the repertoire of sigma factors in P. putida KT2440 and identified 24 sigma factors, 19 of which corresponded to the subfamily of extracytoplasmic function (ECF) sigma factors. We detected 13 ECF sigma factors that showed similarity to the Escherichia coli FecI sigma factor, which is involved in iron acquisition. In 11 cases, a fecR-like gene was found adjacent to the fecI-like gene and, in 10 cases, a gene encoding an iron receptor lies in the vicinity of the fecI/fecR cluster. This may explain the ability of P. putida KT2440 to grow under low iron availability conditions. Five fecI/fecR/iron receptor gene clusters from P. putida were also identified in the human pathogen Pseudomonas aeruginosa.
Optimizing kidney exchange with transplant chains: theory and reality (2012)

Kidney exchange, where needy patients swap incompatible donors with each other, offers a lifesaving alternative to waiting for an organ from the deceased-donor waiting list. Recently, chains---sequences of transplants initiated by an altruistic kidney donor---have shown marked success practice, yet remain poorly understood. We provide a theoretical analysis of the efficacy of chains the most widely used kidney exchange model, proving that long chains do not help beyond chains of length of 3 the This completely contradicts our real-world results gathered from the budding nationwide kidney exchange the United States; there, solution quality improves by increasing the chain length cap to 13 or beyond. We analyze reasons for this gulf between theory and practice, motivated by our experiences running the only nationwide kidney exchange. We augment the standard kidney exchange model to include a variety of real-world features. Experiments the static setting support the theory and help determine how large is really in the large. Experiments the dynamic setting cannot be conducted the large due to computational limitations, but with up to 460 candidates, a chain cap of 4 was best (in fact, better than 5).
A new dual biocide concept for fine papermaking (2010)

Electrochemical generation of oxidants was studied to find new solutions to control microbial contamination at paper mills. Laboratory and semi-pilot trials using a Wet End Simulator indicated that the combination of an electrochemically produced halogen-containing oxidant together with sodium percarbonate was an efficient new biocide concept, especially in fine papermaking. Addition of sodium percarbonate considerably reduced the need for halogen-containing biocides, thus lessening risk of corrosion. The trials with samples from fine paper machines indicated that the new concept required halogenated biocides to be dosed first, and the time delay between additions of biocide needed to be sufficient to ensure that no residual halogen was left when sodium percarbonate was added. Electrochemical generation enables on-site biocide production, which decreases transportation cost, risk associated with storage of hazardous chemicals, and biocide lost due to degradation. Thus, on-site generation of biocides together with potential reduction in amount of halogen containing oxidants make this dual concept economically attractive and environmentally positive.
P-Glycoprotein Efflux Inhibition by Amphiphilic Diblock Copolymers: Relationship between Copolymer Concentration and Substrate Hydrophobicity (2008)

The utilization of surfactants to increase intestinal absorption of drugs is a viable strategy that benefits from increases in drug solubilization and the potential for inhibition of P-glycoprotein (P-gp) mediated efflux. However, the effective concentration range for P-gp inhibition of most surfactants is defined over a narrow concentration range, below the critical micelle concentration (CMC), as a result of significant micelle sequestration of drug. Therefore, the objectives of these studies were to assess if association of P-gp substrates differing in hydrophobicity will impact the effective concentration range for P-gp inhibition by amphiphilic diblock copolymers based on methoxypolyethylene glycol-block-polycaprolatone (MePEG-b-PCL). Comparisons between the micelle association and Caco-2 cellular accumulation were evaluated using two structurally homologous P-gp substrates, the relatively hydrophobic R-6G and the hydrophilic R-123, over concentrations above and below the CMC for MePEG-b-PCL diblock copolymers. An approximately 3.75-fold enhancement of R-123 accumulation occurred with 2 mM MePEG17-b-PCL5, compared to approximately 1.25-fold for R-6G. This decrease in the accumulation enhancement corresponds with the higher R-6G fraction (0.75) associated at 2 mM MePEG17-b-PCL5 compared with R-123 (0.25). Interestingly, R-6G accumulation was enhanced over a very broad range of MePEG17-b-PCL5 concentrations below the CMC. This was in contrast to R-123, which demonstrated no enhancement below the CMC. A similar concentration dependent accumulation profile was seen with other surfactants such as vitamin E TPGS and Cremophor EL and with two other P-gp substrates differing in hydrophobicity, the relatively hydrophobic paclitaxel and hydrophilic doxorubicin. In conclusion, the effective concentration range for surfactant mediated inhibition of P-gp appears to depend on the P-gp substrate hydrophobicity.
Novel Syntheses of the Major Flavor Components of Bread and Cooked Rice (1996)

A new synthetic pathway toward the Maillard flavor compounds 6-acyl-1,2,3,4-tetrahydropyridines and 2-acetyl-1-pyrroline is presented. The reaction sequence involves deprotonation of a vicinal diimine and subsequent alkylation with an N,N-diprotected ω-bromoalkylamine, followed by deprotection and intramolecular transimination of the functionalized intermediate. Acidic workup affords the above-mentioned heterocycles, which are principal flavor constituents of bread and cooked rice, respectively. In addition, the synthesis of the more stable diethyl acetal of 2-acetyl-1-pyrroline is described. Keywords: Rice flavor; bread flavor; 2-acetyl-1-pyrroline; 6-acetyl-1,2,3,4-tetrahydropyridine; Maillard
Conversion of Green Fluorescent Protein into a Toxic, Aggregation-prone Protein by C-terminal Addition of a Short Peptide (2005)

A non-natural 16-residue "degron" peptide has been reported to convey proteasome-dependent degradation when fused to proteins expressed in yeast (Gilon, T., Chomsky, O., and Kulka, R. (2000) Mol. Cell. Biol. 20, 7214-7219) or when fused to green fluorescent protein (GFP) and expressed in mammalian cells (Bence, N. F., Sampat, R. M., and Kopito, R. R. (2001) Science 292, 1552-1555). We find that expression of the GFP::degron in Caenorhabditis elegans muscle or neurons results in the formation of stable perinuclear deposits. Similar perinuclear deposition of GFP::degron was also observed upon transfection of primary rat hippocampal neurons or mouse Neuro2A cells. The generality of this observation was supported by transfection of HEK 293 cells with both GFP::degron and DsRed(monomer)::degron constructs. GFP::degron expressed in C. elegans is less soluble than unmodified GFP and induces the small chaperone protein HSP-16, which co-localizes and co-immunoprecipitates with GFP::degron deposits. Induction of GFP::degron in C. elegans muscle leads to rapid paralysis, demonstrating the in vivo toxicity of this aggregating variant. This paralysis is suppressed by co-expression of HSP-16, which dramatically alters the subcellular distribution of GFP::degron. Our results suggest that in C. elegans, and perhaps in mammalian cells, the degron peptide is not a specific proteasome-targeting signal but acts instead by altering GFP secondary or tertiary structure, resulting in an aggregation-prone form recognized by the chaperone system. This altered form of GFP can form toxic aggregates if its expression level exceeds the capacity of chaperone-based degradation pathways. GFP::degron may serve as an instructive "generic" aggregating control protein for studies of disease-associated aggregating proteins, such as huntingtin, alpha-synuclein, and the beta-amyloid peptide.