gebhart/patrepeval huggingface dataset:
The systematic error correction in measurement transduction of the physical quantities X, X/sup 2/ and X/sup 3/ (2002)

The paper develops the theory of correcting the systematic errors for the care with measurement and calculation transduction of physical quantity X into X, X/sup 2/ and X/sup 3/ under the nonlinear function of sensor or measurement transducer. The paper enumerates the problem for the systematic error correction theory at which the scientists' efforts should be directed. The systematic error correction algorithms are derived and represented for some special cases with the transfer functions. Also, the paper discusses the theoretical and practical problems of implementing the directional effects method i.e. the generalized systematic error correction one.
Comments on "Nonthermal effects of extremely high-frequency microwaves on chromatin conformation in cells in vitro-dependence on physical, physiological, and genetic factors" [comment and reply] (2002)

As long-time workers on development of microwave safe-exposure standards, we are keenly aware of the deficient quality in many of the papers in the bioeffect literature, particularly those relating to microwave artifacts. In the November 2000 issue of this Transactions there are many good papers but there are also papers displaying deficiencies. We are not able to review all such deficiencies, but we restrict our comments here to the above paper [see ibid., vol. 44, no. 11, p. 2172-9, 2000], which makes the extraordinary claim of a significant microwave bioeffect at an incident power density of 10/sup -19/ W/cm/sup 2/, well below that of thermal noise in a bandwidth of practical significance. A reply is included.
The Microanatomy of Trabecular Bone Loss in Normal Aging Men and Women (1987)

Histomorphometric changes in normal bone were investigated using tissue from the ilium of 86 women and 98 men, aged 20-90 years. While loss of trabecular volume was common to both sexes, the histologic basis for the loss differed. Decreased formation (expressed primarily as static indices) seemed to be the principal factor in bone loss in men; in women these features remained unchanged, suggesting that increased resorption was the principal factor. Bone loss in women was principally attributable to the total removal of individual trabeculae; conversely in men, there was generalized attenuation of trabecular bone. Similar findings in bone tissues of vertebral bodies suggest that differences in bone remodelling between the sexes produce different patterns of bone loss as a sequence of aging.
A Novel, Practical Synthesis of Estra-1,3,5(10)-triene-3,17.beta.-dicarboxylic Acid 17-tert-Butylamide (SK&F 105656) from Estrone, via a Palladium-Catalyzed Methoxycarbonylation of a 3-Fluorosulfonate (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Novel, Practical Synthesis of Estra-1,3,5(10)-triene-3,17.beta.-dicarboxylic Acid 17-tert-Butylamide (SK&F 105656) from Estrone, via a Palladium-Catalyzed Methoxycarbonylation of a 3-FluorosulfonateMichael A. McGuire, Edmund Sorenson, Franklin W. Owings, Theodore M. Resnick, Margaret Fox, and Neil H. BaineCite this: J. Org. Chem. 1994, 59, 22, 6683–6686Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/jo00101a028https://doi.org/10.1021/jo00101a028research-articleACS PublicationsRequest reuse permissionsArticle Views610Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polyomavirus BK Viremia in Kidney Transplant Recipients After Desensitization With IVIG and Rituximab (2013)

Desensitization with IVIG and rituximab is associated with a higher incidence of BKV viremia with high viral copies and was the major predictor of BKV viremia in the multivariable model. More frequent surveillance for BKV viremia and an early, aggressive treatment strategy are essential for preventing high BKV viral loads in this patient population.
G proteins as a biochemical tool for diagnosis and monitoring treatments of mental disorders. (2000)

There is a significant gap between advances in medication for mental disorders and the present static situation of diagnosis and monitoring treatments of these disorders. Heterotrimeric G proteins play a pivotal role in postreceptor information transduction. These proteins were previously implicated by us in the biochemical mechanism underlying lithium action, and in the pathophysiology of mood disorders. We aimed at quantitatively and functionally evaluating G proteins in patients with major mental disorders in an attempt to unravel a differential pattern of G protein measures characterizing each disorder. We undertook G protein functional measurements coupled to beta-adrenergic, muscarinic or dopamine receptors through bacterial toxin-sensitive, agonist-enhanced [3H]-Gpp(NH)p binding capacity, substituted by quantitative measures of G alpha s, G alpha i, and G beta subunit proteins through immunoblot analysis using polyclonal anti-G submit antibodies in mononuclear leukocytes obtained from patients with major mental disorders in comparison with healthy volunteers. A differential pattern of receptor coupled G protein function and of their immunoreactive levels were detected in mononuclear leukocytes of patient s for the following mental disorders: mania, depression, schizophrenia, and panic. Normalization of altered G protein measures in mood-disorder ed patients occurred under specific treatments. As state-dependent markers, G protein measures can potentially be used as an aid in both the biochemical diagnosis of mental disorders and in the biochemical monitoring of the response to a specific treatment.
File system measurements and their application to the design of efficient operation logging algorithms (2002)

File system operation in a transparently fault-tolerant system that uses checkpointing and message logging is discussed. Logging messages to disk is one of the primary performance costs of such systems. The author has measured the file system operations performed on large timesharing systems running Unix in terms of the level of concurrency (number of consecutive operations that do not change the state of the file system). By performing much of the data analysis online within a modified Unix kernel, statistics were collected over a long period of time with a substantial variation in system load. Using this data, it is demonstrated that a technique called null logging can reduce the number of messages logged to disk by a factor of 10 to 25, depending on the workload. This reduces the overhead of the fault-tolerance mechanism and allows a large fraction of file system operations to commit instantaneously.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Topical E6005, a novel phosphodiesterase 4 inhibitor, attenuates spontaneous itch‐related responses in mice with chronic atopy‐like dermatitis (2014)

Atopic dermatitis is a chronic inflammatory cutaneous disease with difficult-to-treat pruritus. Although phosphodiesterase (PDE) 4 inhibitors have an anti-inflammatory effect on inflammatory skin diseases, such as atopic dermatitis, their acute antipruritic activities remain unclear. Therefore, in this study, we examined whether E6005, a novel PDE4 inhibitor, has antipruritic activity in dermatitis, using a mouse model of atopic dermatitis (NC/Nga mice). A single topical application of E6005 inhibited spontaneous hind-paw scratching, an itch-associated response and spontaneous activity of the cutaneous nerve in mice with chronic dermatitis. The cutaneous concentration of cAMP was significantly decreased in mice with chronic dermatitis, and this decrease was reversed by topical E6005 application. These results suggest that E6005 increases the cutaneous concentration of cAMP to relieve dermatitis-associated itching. Thus, E6005 may be a useful therapy for pruritic dermatitis such as atopic dermatitis.
Impact of Multidrug-Resistant Pseudomonas aeruginosa Bacteremia on Patient Outcomes (2010)

Trends of rising rates of resistance in Pseudomonas aeruginosa make selection of appropriate empirical therapy increasingly difficult, but whether multidrug-resistant (MDR) P. aeruginosa is associated with worse clinical outcomes is not well established. The objective of this study was to determine the impact of MDR (resistance to three or more classes of antipseudomonal agents) P. aeruginosa bacteremia on patient outcomes. We performed a retrospective cohort study of adult patients with P. aeruginosa bacteremia from 2005 to 2008. Patients were identified by the microbiology laboratory database, and pertinent clinical data were collected. Logistic regression was used to explore independent risk factors for 30-day mortality. Classification and regression tree analysis was used to determine threshold breakpoints for continuous variables. Kaplan-Meier survival analysis was used to compare time to mortality, after normalization of the patients' underlying risks by propensity scoring. A total of 109 bacteremia episodes were identified; 25 episodes (22.9%) were caused by MDR P. aeruginosa. Patients with MDR P. aeruginosa bacteremia were more likely to receive inappropriate empirical therapy (44.0% and 6.0%, respectively; P < 0.001) and had longer prior hospital stays (32.6 +/- 37.3 and 14.4 +/- 43.6 days, respectively; P = 0.046). Multivariate regression revealed that 30-day mortality was associated with multidrug resistance (odds ratio [OR], 6.8; 95% confidence interval [CI], 1.9 to 24.0), immunosuppression (OR, 5.0; 95% CI, 1.4 to 17.5), and an APACHE II score of > or = 22 (OR, 29.0; 95% CI, 5.0 to 168.2). Time to mortality was also shorter in the MDR cohort (P = 0.011). Multidrug resistance is a significant risk factor for 30-day mortality in patients with P. aeruginosa bacteremia; efforts to curb the spread of MDR P. aeruginosa could be beneficial.
Lateral Tegmental Pontine Haemorrhage due to Vascular Malformations (1991)

Lateral tegmental pontine haemorrhages were diagnosed in 3 young, normotensive patients. All had stereotyped symptoms and signs. In 2, the onset was subacute, and the haemorrhage was recurrent, suggesting the presence of an underlying vascular malformation. The diagnoses were established by computerised tomography or magnetic resonance imaging, with angiographic abnormalities confirmed in all cases. Two patients had surgical management and 1 had stereotactic radiosurgery. The risks and potential benefits of these therapeutic options are discussed.
Data Analysis and Statistical Interpolation of Signals for Human Footstep Tracking Using Intelligent Carpet (2016)

This article describes an intelligent carpet for human footstep detection and tracking. The carpet consists of textile based piezoresistive layer sandwiched between crossed conductive wires to make pressure sensor grids or pixels inside the carpet. Further, a preliminary noise filtering and signal extraction have been demonstrated by means of data analysis and statistical interpolation of signals (pressure based resistance change) obtained from the carpet.
Er: YAG Laser Resurfacing Using Combined Ablation and Coagulation Modes (2001)

BACKGROUND The two main laser types used in resurfacing, the CO2 and the Er:YAG lasers, have their supporters and detractors, and each system has clear advantages and disadvantages. OBJECTIVE The Er:YAG laser can be used in the usual efficient ablative mode, followed by reprogramming to achieve nonablative deeper dermal coagulation associated with the CO2 laser, thereby achieving the main advantages of both laser types. PATIENTS AND METHODS Twenty-three female patients, ages 42–72 yrs, skin types I–IV, were treated. The epidermis was first removed in the ablative settings in a single pass with 50% overlap. The Er:YAG laser was reprogrammed for the subablative mode, and several passes produced controlled residual thermal damage (RTD) without further ablation. RESULTS At 2 months postresurfacing the results were assessed. Thirteen patients were rated “very good,” eight as “good,” and two as “fair.” CONCLUSION The dual mode Er:YAG laser can first be used in the ablative mode to remove the epidermis with minimal RTD, following which, in the subablative mode, the same laser induces a controlled layer of dermal RTD, stimulating the dermis to achieve collagenesis and collagen remodeling and giving good long-term results.
A Self-Organizing Storage Cluster for Parallel Data-Intensive Applications (2005)

Cluster-based storage systems are popular for data-intensive applications and it is desirable yet challenging to provide incremental expansion and high availability while achieving scalability and strong consistency. This paper presents the design and implementation of a self-organizing storage cluster called Sorrento, which targets data-intensive workload with highly parallel requests and low write-sharing patterns. Sorrento automatically adapts to storage node joins and departures, and the system can be configured and maintained incrementally without interrupting its normal operation. Data location information is distributed across storage nodes using consistent hashing and the location protocol differentiates small and large data objects for access efficiency. It adopts versioning to achieve single-file serializability and replication consistency. In this paper, we present experimental results to demonstrate features and performance of Sorrento using microbenchmarks, application benchmarks, and application trace replay.
Synthesis and Biodistribution Studies of 3H- and 64Cu-Labeled Dendritic Polyglycerol and Dendritic Polyglycerol Sulfate (2015)

Dendritic polyglycerol sulfate (dPGS) is a biocompatible, bioactive polymer which exhibits anti-inflammatory activity in vivo and thus represents a promising candidate for therapeutic and diagnostic applications. To investigate the in vivo pharmacokinetics in detail, dPGS with a molecular weight of approx. 10 kDa was radiolabeled with (3)H and (64)Cu, and evaluated by performing biodistribution studies and small animal positron emission tomography (PET). (3)H-labeling was accomplished by an oxidation-reduction process with sodium periodate and [(3)H]-borohydride. (64)Cu-labeling was achieved by conjugation of isothiocyanate- or maleimide-functionalized copper(II)-chelating ligands based on 1,4-bis(2-pyridinylmethyl)-1,4,7-triazacyclononane (DMPTACN) to an amino functionalized dPGS scaffold, followed by reaction with an aqueous solution containing (64)CuCl2. Independent biodistribution by radioimaging and PET imaging studies with healthy mice and rats showed that the neutral dPG was quantitatively renally eliminated, whereas the polysulfated analogues accumulated mainly in the liver and spleen. Small amounts of the dPGS derivatives were slowly excreted via the kidneys. The degree of uptake by the reticuloendothelial system (RES) was similar for dPGS with 40% or 85% sulfation, and surface modification of the scaffold with the DMPTACN chelator did not appear to significantly affect the biodistribution profile. On the basis of our data, the applicability of bioactive dPGS as a therapeutic agent might be limited due to organ accumulation even after 3 weeks. The inert characteristics and clearance of the neutral polymer, however, emphasizes the potential of dPG as a multifunctional scaffold for various nanomedical applications.
Cell Type-Specific Tumor Suppression by Ink4a and Arf in Kras-Induced Mouse Gliomagenesis (2005)

Homozygous deletion of the INK4a-ARF locus is one of the most frequent mutations found in human glioblastoma. We have previously shown that combined Ink4a-Arf loss can increase tumor incidence in both glial progenitor cells and astrocytes during mouse gliomagenesis. Here we have investigated the separate contribution of loss of each of the tumor suppressor genes in glial progenitor cells and astrocytes in Akt + Kras-induced gliomagenesis. We show that Arf is the major tumor suppressor gene in both cell types. Arf loss generated glioblastomas from both nestin-expressing glial progenitor cells and glial fibrillary acidic protein-expressing astrocytes, with a significantly higher incidence in astrocytes. Ink4a loss, on the other hand, could only significantly contribute to gliomagenesis from glial progenitor cells and the induced tumors were of lower malignancy than those seen in Arf-deficient mice. Thus, Ink4a and Arf have independent and differential tumor suppressor functions in vivo in the glial cell compartment.
Functional CeOx nanoglues for efficient and robust atomically dispersed catalysts (2021)

Abstract Single-atom catalysts (SACs) exhibit unique catalytic property and maximum atom efficiency of rare, expensive metals. A critical barrier to applications of SACs is sintering of active metal atoms under operating conditions. Anchoring metal atoms onto oxide supports via strong metal-support bonds may alleviate sintering. Such an approach, however, usually comes at a cost: stabilization results from passivation of metal sites by excessive oxygen ligation—too many open coordination sites taken up by the support, too few left for catalytic action. Furthermore, when such stabilized metal atoms are activated by reduction at elevated temperatures they become unlinked and so move and sinter, leading to loss of catalytic function. We report a new strategy, confining atomically dispersed metal atoms onto functional oxide nanoclusters (denoted as nanoglues) that are isolated and immobilized on a robust, high-surface-area support—so that metal atoms do not sinter under conditions of catalyst activation and/or operation. High-number-density, ultra-small and defective CeOx nanoclusters were grafted onto high-surface-area SiO2 as nanoglues to host atomically dispersed Pt. The Pt atoms remained on the CeOx nanoglue islands under both O2 and H2 environment at high temperatures. Activation of CeOx supported Pt atoms increased the turnover frequency for CO oxidation by 150 times. The exceptional stability under reductive conditions is attributed to the much stronger affinity of Pt atoms for CeOx than for SiO2—the Pt atoms can move but they are confined to their respective nanoglue islands, preventing formation of larger Pt particles. The strategy of using functional nanoglues to confine atomically dispersed metal atoms and simultaneously enhance catalytic performance of localized metal atoms is general and takes SACs one major step closer to practical applications as robust catalysts for a wide range of catalytic transformations
Convolutional neural networks (CNN) based human fall detection on Body Sensor Networks (BSN) sensor data (2017)

According to the World Health Organization, around 28-35% of people aged 65 and older fall each year. This number increases to around 32-42% for people over 70 years old. For this reason, this research targets the exploration of the role of Convolutional Neural Networks(CNN) in human fall detection. There are a number of current solutions related to fall detection; however, remain low detection accuracy. Although CNN has proven a powerful technique for image recognition problems, and the CNN library in Matlab was designed to work with either images or matrices, this research explored how to apply CNN to streaming sensor data, collected from Body Sensor Networks (BSN), in order to improve the fall detection accuracy. The idea of this research is that given the stream data sets as input, we converted them into images before applying CNN. The final accuracy result achieved is, to the best of our knowledge, the highest compared to other proposed methods: 92.3%.
Consumer Preferences for Meat Products Blended with Plant-Based Proteins in Germany (2020)

High levels ofmeat consumption are increasingly being criticised for ethical, environmental, 2 and social reasons. Plant-based meat substitutes have been identified as healthy sources of protein in 3 comparison to meat. This alternative offers several social, environmental and health benefits and may 4 play a role in reducing meat consumption. However, there has been a lack of research on how specific 5 meat substitute attributes can influence consumers to replace or partially replace meat in their diets. 6 Research demonstrates that in many countries consumers are highly attached to meat.They consider 7 it as an essential and integral element of their daily diet. For these consumers which are not interested 8 in vegan or vegetarian alternatives to meat, so-called meathybrids could be a low-threshold option 9 for a more sustainable food consumption behaviour. In meathybrids only a fraction of the meat 10 product (e.g. 20% to 50%) is replaced with plant-based proteins. In this paper, the results of an online 11 survey with 500 German consumers are presented with focus on preferences and attitudes relating 12 to meathyrids. The results show that more than fifty percent of consumers substitute meat at least 13 occasionally. Thus, about half of the respondents reveal an eligible consumption behaviour in respect 14 to sustainability and healthiness to a certain degree. Concerning the determinants of choosing either 15 meathybrid or meat it becomes evident that the highest effect is exerted by the health perception. The 16 healthier meathybrids are perceived, the higher is the choice probability. Thus, this egoistic motive 17 seems to outperform altruistic motives like animal welfare or environmental concerns when it comes 18 to choice for this new product category.
A Dynamic, Globally Diversified, Index Neutral Synthetic Asset Allocation Strategy (1997)

An investor with the ability to assess the prospective return and risk structure of the global capital markets can construct portfolios that, over time, will not only outperform actively or passively managed domestic asset portfolios but will also outperform passively managed global portfolios. A Bayesian approach to dynamic seemingly unrelated regression (DSUR) is a robust and effective means to forecast the one-step ahead, conditional distribution of asset returns. This approach recognizes the time-varying nature of the global capital markets. The predictive moments are used to derive a single-factor return model once an index portfolio is specified. The index portfolio represents an investor's underlying portfolio. Given the factor model that assesses the relative attractiveness and risk of the assets in relation to the index, an index neutral portfolio is constructed as an overlay to enhance the returns of the index portfolio. This portfolio is mean-variance optimal, is notional neutral (i.e., the sum of the asset exposures is zero), and has returns that are designed to be uncorrelated with the returns of the index portfolio. The implementation of such an index neutral portfolio using derivative securities is simulated over the period January 1988 to December 1993.