gebhart/patrepeval huggingface dataset:
Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to the heterotypic neutralization domain of VP7 and the VP8 fragment of VP4 (1989)

A murine model was used to determine whether neutralizing monoclonal antibodies (MAbs) with heterotypic specificity directed to VP7 (MAb 57-8) or to the VP8 fragment of VP4 (MAb M14) passively protect mice against challenge with various strains of rotavirus. (The gene 4 product, an outer capsid protein, has traditionally been called VP3. It has been proposed, however, that the rotavirus gene 4 product be named VP4. The gene 3 product, a core protein, has been identified recently and named VP3 [M. Liu, P. A. Offit, and M. K. Estes, Virology 163:28-32, 1988]). Suckling mice orally inoculated with MAb 57-8 did not develop diarrhea when challenged with virulent serotype 3, 4, or 6 rotaviruses, while those inoculated with MAb M14 were passively protected from challenge with serotype 3 or 6 rotaviruses, as predicted by in vitro neutralization tests. These MAbs, however, did not protect mice from infection when the mice were challenged with rotaviruses of other serotypes. We conclude that specific neutralization epitopes on each surface protein are capable of mediating protection against one or several rotavirus serotypes.
Cathodoluminescence from Amorphous and Nanocrystalline Nitride Thin Films Doped with Rare Earth and Transition Metals (2012)

Cathodoluminescence from Amorphous and Nanocrystalline Nitride Thin Films Doped with Rare Earth and Transition Metals
Identification of Human Glandular Kallikrein hK2 From LNCaP Cells (1996)

Based on studies indicating that human glandular kallikrein (hK2) mRNA is present in the prostate, we prepared a monoclonal antibody to a synthetic peptide corresponding to the 41-56 region of hK2 to try to identify the hK2 protein. Although prostate-specific antigen (PSA) and hK2 share 80% homology, the 41-56 amino acid sequence of hK2 is only 50% homologous with PSA. A monoclonal antibody, HK1A523, was identified that demonstrates high specificity for hK2. In western blot analysis, the antibody has a 1,000-fold greater sensitivity for the detection of hK2 than for PSA. The antibody was used to probe spent media from the prostate carcinoma cell line, LNCaP. An immunoreactive species was N-terminally sequenced and identified as mature hK2. HK1A523 was also utilized to probe prostate tumor cytosols and seminal fluid where putative forms of hK2 were also identified. The hK2 protein therefore is expressed and secreted from prostate carcinoma cells.
New directions in traffic measurement and accounting (2001)

Accurate network traffic measurement is required for accounting, bandwidth provisioning, and detecting DOS attacks. However, keeping a counter to measure the traffic sent by each of a million concurrent flows is too expensive (using SRAM) or slow (using DRAM). The current state-of-the-art (e.g., Cisco NetFlow) methods which count periodically sampled packets are slow, inaccurate, and memory-intensive. Our paper introduces a paradigm shift by concentrating on the problem of measuring only "heavy" flows --- i.e., flows whose traffic is above some threshold such as 1% of the link. After showing that a number of simple solutions based on cached counters and classical sampling do not work, we describe two novel and scalable schemes for this purpose which take a constant number of memory references per packet and use a small amount of memory. Further, unlike NetFlow estimates, we have provable bounds on the accuracy of measured rates and the probability of false negatives. We also propose a new form of accounting called threshold accounting in which only flows above threshold are charge by usage while the rest are charged a fixed fee. Threshold accounting generalizes the familiar notions of usage-based and duration based pricing.
Ultrashort stretched-pulse L-band laser using carbon-nanotube saturable absorber (2015)

In the paper, a passively mode-locked erbium-doped fiber ring laser in the long-wavelength band (L-band) is presented by using a single-wall nanotube saturable absorber (SWNT-SA). The optical properties of the SWNT-SA are compared with those in the C-band in view of the absorbance spectrum and the power-dependent transmittance of the SWNT-SA film. The effects of the net cavity dispersion and the length of the erbium-doped fiber (EDF) on L-band stretched pulse generation are discussed. The designed stretched-pulse L-band laser has a net dispersion of 0.017-ps<sup>2</sup> and generates ultrashort (110 fs), broad-spectrum (41 nm) pulses with a signal-to-noise ratio over 70 dB.
Quality assurance device for four‐dimensional IMRT or SBRT and respiratory gating using patient‐specific intrafraction motion kernels (2007)

Emerging technologies such as four-dimensional computed tomography (4D CT) and implanted beacons are expected to allow clinicians to accurately model intrafraction motion and to quantitatively estimate internal target volumes (ITVs) for radiation therapy involving moving targets. In the case of intensity-modulated (IMRT) and stereotactic body radiation therapy (SBRT) delivery, clinicians must consider the interplay between the temporal nature of the modulation and the target motion within the ITV. A need exists for a 4D IMRT/SBRT quality assurance (QA) device that can incorporate and analyze customized intrafraction motion as it relates to dose delivery and respiratory gating. We built a 4D IMRT/SBRT prototype device and entered (X, Y, Z)(T) coordinates representing a motion kernel into a software application that 1. transformed the kernel into beam-specific two-dimensional (2D) motion "projections," 2. previewed the motion in real time, and 3. drove a recision X-Y motorized device that had, atop it, a mounted planar IMRT QA measurement device. The detectors that intersected the target in the beam's-eye-view of any single phase of the breathing cycle (a small subset of all the detectors) were defined as "target detectors" to be analyzed for dose uniformity between multiple fractions. Data regarding the use of this device to quantify dose variation fraction-to-fraction resulting from target motion (for several delivery modalities and with and without gating) have been recently published. A combined software and hardware solution for patient-customized 4D IMRT/SBRT QA is an effective tool for assessing IMRT delivery under conditions of intrafraction motion. The 4D IMRT QA device accurately reproduced the projected motion kernels for all beam's-eye-view motion kernels. This device has been proved to, effectively quantify the degradation in dose uniformity resulting from a moving target within a static planning target volume, and, integrate with a commercial respiratory gating system to ensure that the system is working effectively. Such a device is discussed as a potential tool to optimize the gating duty cycle to maximize delivery efficiency while minimizing dose variability.
Energy Awareness and Uncertainty in Microarchitecture-Level Design (2005)

The authors present microarchitecture-level statistical models for characterizing process and system parameter variability, concentrating on gate length and on-chip temperature variations. To assess the effect of microarchitecture decisions on these variations, and vice versa, they propose a joint performance, power, and variability metric that distinguishes among various design choices.
Moulage des alliages d’aluminium - Sable, moulage de précision et procédés apparentés (2013)

&nbsp; Le moulage sable est de loin le plus important des procédés à moule destructible par le tonnage produit. Il permet de réaliser pratiquement tous les types de pièces (grande et petites, massives et minces, hautes caractéristiques et très courantes), tous les volumes de production (ultra grande série pour l’automobile sur chantiers automatisés et pièces à l’unité en moulage manuel). Les autres procédés, moulage sable à modèles gazéifiables (Lost Foam), cire perdue, moulage plâtre, procédé V et moulage sable par ablation (encore en développement) possèdent chacun des créneaux plus étroits.
Efficient Visible-Light-Induced Photocatalytic Disinfection on Sulfur-Doped Nanocrystalline Titania (2005)

Sulfur-doped titanium dioxide exhibits a strong visible-light-induced antibacterial effect. The new photocatalyst can effectively kill Micrococcus lylae, a common Gram-positive bacterium. The relationship between sulfur concentration and the bactericidal activity of S-doped TiO2 was investigated. Results from DMPO spin-trapping electron spin resonance measurements confirm the formation of hydroxyl radicals, which is the origin of the considerable bactericidal activity under visible light irradiation.
Automatic failure recovery for software-defined networks (2013)

Tolerating and recovering from link and switch failures are fundamental requirements of most networks, including Software-Defined Networks (SDNs). However, instead of traditional behaviors such as network-wide routing re-convergence, failure recovery in an SDN is determined by the specific software logic running at the controller. While this admits more freedom to respond to a failure event, it ultimately means that each controller application must include its own recovery logic, which makes the code more difficult to write and potentially more error-prone.
High-throughput functional screening for next-generation cancer immunotherapy using droplet-based microfluidics (2021)

Microfluidics system enables high-throughput functional screening of antibodies for cancer immunotherapy.
Conformationally Constrained Peptides from CD2 To Modulate Protein–Protein Interactions between CD2 and CD58 (2011)

Cell adhesion molecule CD2 and its ligand CD58 provide good examples of protein-protein interactions in cells that participate in the immune response. To modulate the cell adhesion interaction, peptides were designed from the discontinuous epitopes of the β-strand region of CD2 protein. The two strands were linked by a peptide bond. β-Strands in the peptides were nucleated by inserting a β-sheet-inducing (D)-Pro-Pro sequence or a dibenzofuran (DBF) turn mimetic with key amino acid sequences from CD2 protein that binds to CD58. The solution structures of the peptides (5-10) were studied by NMR and molecular dynamics simulations. The ability of these peptides to inhibit cell adhesion interaction was studied by E-rosetting and lymphocyte epithelial assays. Peptides 6 and 7 inhibit the cell adhesion activity with an IC(50) of 7 and 11 nM, respectively, in lymphocyte epithelial adhesion assay. NMR and molecular modeling results indicated that peptides 6 and 7 exhibited β-hairpin structure in solution.
An unstable manganese(III) complex incorporating ligand donor types proposed for an acid phosphatase from sweet potato: (p-nitrobenzenethiolato)[N,N'-ethylenebis(salicylideneaminato)]manganese(III) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn unstable manganese(III) complex incorporating ligand donor types proposed for an acid phosphatase from sweet potato: (p-nitrobenzenethiolato)[N,N'-ethylenebis(salicylideneaminato)]manganese(III)Joel W. Gohdes and William H. ArmstrongCite this: Inorg. Chem. 1988, 27, 11, 1841–1842Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ic00284a001https://doi.org/10.1021/ic00284a001research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
BRAFmutation as a novel driver of eosinophilic cystitis (2017)

Eosinophilic cystitis is a rare manifestation of hypereosinophilia and a cause of morbidity, including dysuria and hematuria. Although some cases can be attributed to infection or allergy, most cases are assessed to be idiopathic and treated with corticosteroids. However, hypereosinophilia can also be due to actionable clonal molecular alterations in the haematopoietic cells, similar to other myeloproliferative neoplasms. Common mutations associated with eosonophilic syndromes are of platelet-derived growth factor receptor α or β or c-kit, though other pathogenic mutations have been found by next generation sequencing. Determination of a specific mutation may therefore identify clonality and refine treatment of some cases. Here we review the molecular features of eosinophilic disorders. We also describe the use of a liquid biopsy of circulating cell-free DNA in the workup of a case of eosinophilic cystitis in which next generation sequencing of cell-free DNA showed a BRAF I463T mutation. In silico modeling supports the functional impact and potential clinical relevance of BRAF I463T.
Purification and properties of acid pectinesterase from Corticium rolfsii. (1977)

A pectinesterase was purified from the culture filtrate of C. rolfsii IFO 6146 by a combination of salting out, gel filtration on Sephadex G-100 and chromatography on DEAE-Sephadex A-50, SP-Sephadex C-50 and hydroxylapatite. The purified enzyme was found to be homogeneous protein by ultracentrifugal analysis. The molecular weight of the purified enzyme was found to be about 37, 000 by the gel filtration. The enzyme was stable over the pH range of 1.1 to 10.0 and retained 90% of its activity when stored at pH 1.1 at 5°C for 72 hr. The maximum activity occurred at pH 2.5 to 4.5 at 45°C. The enzyme was fairly active at a very low pH (1.1) or low temperature (10°C). Hg2+ was a potent inhibitor. The enzyme was active not only on high molecular pectin methyl esters but also on low molecular esters. The high enzymatic activity at very low pH values and the unusual tolerance to hydrogen ions are characteristics of pectinesterase from C. rolfsii. The enzyme is one of the acid esterases.
Spectral_li-ion_SPM: Initial release (2016)

Spectral li-ion SPM is a MATLAB code that solves the so-called lithium-ion battery Single Particle Model (SPM) using spectral numerical methods.
Game design as marketing: How game mechanics create demand for virtual goods (2010)

Selling virtual goods for real money is an increasingly popular revenue model for massively-multiplayer online games (MMOs), social networking sites (SNSs) and other online hangouts. In this paper, we argue that the marketing of virtual goods currently falls short of what it could be. Game developers have long created compelling game designs, but having to market virtual goods to players is a relatively new situation to them. Professional marketers, on the other hand, tend to overlook the internal design of games and hangouts and focus on marketing the services as a whole. To begin bridging the gap, we propose that the design patterns and game mechanics commonly used in games and online hangouts should be viewed as a set of marketing techniques designed to sell virtual goods. Based on a review of a number of MMOs, we describe some of the most common patterns and game mechanics and show how their effects can be explained in terms of analogous techniques from marketing science. The results provide a new perspective to game design with interesting implications to developers. Moreover, they also suggest a radically new perspective to marketers of ordinary goods and services: viewing marketing as a form of game design.
Development of gamma-tocotrienol as a radiation medical countermeasure for the acute radiation syndrome: current status and future perspectives (2023)

GT3 is a newer type of radioprotector having significant injury-countering potential and is currently under advanced development for H-ARS. As a pre-exposure drug, it requires only single doses, lacks significant toxicity, and has minimal, ambient temperature storage requirements; thus, GT3 appears to be an ideal MCM for military and first responders as well as for storage in the Strategic National Stockpile.
Das ISO-Referenzmodell für offene Systeme und seine sieben Schichten (1986)

The essential oil from Satureja Khuzestanica Jamzad (SKEO), an endemic plant from Iran, was evaluated for its activity against inflammatory bowel disease (IBD). SKEO was examined on the experimental mouse model of inflammatory bowel disease, which is acetic acid-induced colitis. Prednisolone was used as the standard drug for comparison. Biochemical, macroscopic, and microscopic examinations of colon were performed. Lipid peroxidation significantly increased in acetic acid-treated mice in comparison to the normal group (4.88 vs. 3.02 mumol/g) and was significantly restored by SKEO (500, 1000, 1500 ppm) and prednisolone treatment. The mean percentage of decreases of lipid peroxidation in SKEO (500, 1000, 1500 ppm)- and prednisolone-treated groups were 10.5, 28.5, 42.85, and 33.33 of control, respectively. The myeloperoxidase activity significantly increased in acetic acid-treated mice in comparison to the normal group (4.1 vs. 0.8 U/g) and significantly restored in SKEO (1000 and 1500 ppm)- and prednisolone-treated groups. The mean percentage of decreases of myeloperoxidase activity in SKEO (1000 and 1500 ppm)- and prednisolone-treated groups were 24.56, 50, and 52.63 of control, respectively. SKEO (1000 and 1500 ppm)- and prednisolone-treated groups showed significantly lower score values of macroscopic and microscopic characters when compared to the acetic acid-treated group. The beneficial effect of SKEO (1500 ppm) was comparable to that of prednisolone. Known antioxidant, antimicrobial, antiinflammatory, and antispasmodic potentials of Satureja Khuzestanica may be the mechanisms by which this plant protects animals against experimentally induced IBD. Proper clinical investigation should be carried out to confirm the activity in human disease.
Shack–Hartmann versus reverse Hartmann wavefront sensors: experimental results (2020)

With respect to the classical Shack-Hartmann (SH) wavefront sensor (WFS), the recently proposed reverse Hartmann (RH) sensor inverts the locations of the filtering and observation planes and forms a direct image of the pupil on a detector array. The slopes of the wavefront error (WFE) are then reconstructed by using a double Fourier transform algorithm. It turns out that the same algorithm can also be applied to the raw data acquired by SH sensors. This Letter presents the first, to the best of our knowledge, experimental results obtained with a simplified RH WFS and their comparison to those provided by a reference SH sensor, in both classical and double Fourier transform modes. They demonstrate that similar WFE measurement accuracy is achievable when using the three techniques, at least within the limit of our test bench that is estimated around $\lambda/10$λ/10 RMS.
Fièvre catarrhale du mouton. Convention d'appui technique du CIRAD-EMVT à la DGAL, rapport technique 2001 (2002)

Ce rapport technique présente l'ensemble des résultats de surveillance sérologique et entomologique en Corse et sur le continent prévus par la convention DGAL-CIRAD 2001 et détaille les activités complémentaires réalisées par le CIRAD à la demande de la DGAL pour faire face à l'évolution de la fièvre catarrhale dans le pays (suspicion de fièvre catarrhale dans le Cantal, enquête écotoxicologique en Corse, enquête sur les causes des échecs vaccinaux en Corse, enquête sérologique sur ovins vaccinés en Corse, programme européen d'éradication).
Supplementary Figure 3c from Targeting ALDH<sup>bright</sup> Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8<sup>+</sup> T Cells (2023)

&lt;p&gt;PDF file - 43KB&lt;/p&gt;
Scales to assess psychosis in Parkinson's disease: Critique and recommendations (2008)

Psychotic symptoms are a frequent occurrence in Parkinson's disease (PD), affecting up to 50% of patients. The Movement Disorder Society established a Task Force on Rating Scales in PD, and this critique applies to published, peer-reviewed rating psychosis scales used in PD psychosis studies. Twelve psychosis scales/questionnaires were reviewed. None of the reviewed scales adequately captured the entire phenomenology of PD psychosis. While the Task Force has labeled some scales as "recommended" or "suggested" based on the fulfilling-defined criteria, none of the current scales contained all the basic content, mechanistic and psychometric properties needed to capture PD psychotic phenomena and to measure clinical response over time. Different scales may be better for some settings versus others. Since one scale may not be able to serve all needs, a scale used to measure clinical response and change over time [such as the Clinical Global Impression Scale (CGIS)] may need to be combined with another scale better at cataloging specific features [such as the Neuropsychiatric Inventory (NPI) or Schedule for Assessment of Positive Symptoms (SAPS)]. At the present time, for clinical trials on PD psychosis assessing new treatments, the following are recommended primary outcome scales: NPI (for the cognitively impaired PD population or when a caregiver is required), SAPS, Positive and Negative Syndrome Scale (PANSS), or Brief Psychiatric Rating Scale (BPRS) (for the cognitively intact PD population or when the patient is the sole informant). The CGIS is suggested as a secondary outcome scale to measure change and response to treatment over time.
Correction to "The Generalized Stochastic Likelihood Decoder: Random\n Coding and Expurgated Bounds" (2017)

This purpose of this letter is to handle a gap that was found in the proof of\nTheorem 2 in the paper "The generalized stochastic likelihood decoder: random\ncoding and expurgated bounds."\n