gebhart/patrepeval huggingface dataset:
Antibody formation towards porcine tissue in patients implanted with crosslinked heart valves is directed to antigenic tissue proteins and αGal epitopes and is reduced in healthy vegetarian subjects (2017)

Immune response in patients towards ga-pV is induced by the porcine proteins albumin and collagen 6A1 as well as αGal epitopes, which seemed to be more sustained. In contrast, in healthy young subjects pre-formed anti-Gal antibodies were reduced by a meat-free nutrition.
Biocompatible Europium Doped Hydroxyapatite Nanoparticles as a Biological Fluorescent Probe (2010)

In this study, a cell labelling method is presented using biocompatible europium doped hydroxyapatite (Eu-HAP) inorganic nanoparticles. Eu-HAP nanoparticles were successfully prepared by precipitation method and utilized to label Bel-7402 human liver cancer cells as fluorescent probe. After Eu-HAP nanoparticles were internalized by cells, the strong green fluorescence and the red fluorescence were observed with excitation of blue light and green light respectively. Results show that the Eu-HAP nanoparticles exhibit the potential to become valuable biocompatible fluorescent labelling material in biological studies.
Design and performance analysis of a noncoherent code tracking loop with variable loop bandwidth (2004)

In this paper, the performance of a noncoherent DLL code tracking loop with a variable loop bandwidth is analyzed in detail and some practical design issues for loop filter are discussed. First, an analytical closed-form expression on steady-state jitter variance is derived as a function of a pulse-shaping filter, timing offset, signal-to-interference ratio, and a loop bandwidth. A noncoherent code tracking loop with a variable loop bandwidth is then designed for application to WCDMA mobile stations and its performance is verified by computer simulation.
Noninvasive determination of the optical properties of two-layered turbid media (1998)

Light propagation in two-layered turbid media having an infinitely thick second layer is investigated in the steady-state, frequency, and time domains. A solution of the diffusion approximation to the transport equation is derived by employing the extrapolated boundary condition. We compare the reflectance calculated from this solution with that computed with Monte Carlo simulations and show good agreement. To investigate if it is possible to determine the optical coefficients of the two layers and the thickness of the first layer, the solution of the diffusion equation is fitted to reflectance data obtained from both the diffusion equation and the Monte Carlo simulations. Although it is found that it is, in principle, possible to derive the optical coefficients of the two layers and the thickness of the first layer, we concentrate on the determination of the optical coefficients, knowing the thickness of the first layer. In the frequency domain, for example, it is shown that it is sufficient to make relative measurements of the phase and the steady-state reflectance at three distances from the illumination point to obtain useful estimates of the optical coefficients. Measurements of the absolute steady-state spatially resolved reflectance performed on two-layered solid phantoms confirm the theoretical results.
Cytosine Methylation Profiles as a Molecular Marker in Non–Small Cell Lung Cancer (2006)

Aberrant promoter methylation is frequently observed in different types of lung cancer. Epigenetic modifications are believed to occur before the clinical onset of the disease and hence hold a great promise as early detection markers. Extensive analysis of DNA methylation has been impeded by methods that are either too labor intensive to allow large-scale studies or not sufficiently quantitative to measure subtle changes in the degree of methylation. We used a novel quantitative DNA methylation analysis technology to complete a large-scale cytosine methylation profiling study involving 47 gene promoter regions in 96 lung cancer patients. Each individual contributed a lung cancer specimen and corresponding adjacent normal tissue. The study identified six genes with statistically significant differences in methylation between normal and tumor tissue (P < 10(-6)). We explored the quantitative methylation data using an unsupervised hierarchical clustering algorithm. The data analysis revealed that methylation patterns differentiate normal from tumor tissue. For validation of our approach, we divided the samples to train a classifier and test its performance. We were able to distinguish normal from lung cancer tissue with >95% sensitivity and specificity. These results show that quantitative cytosine methylation profiling can be used to identify molecular classification markers in lung cancer.
Extranodal presentation of non-Hodgkin's lymphomas in the testis (1976)

The clinical and pathologic features of six patients, each of whom exhibited a testicular mass as the first sign of a lymphoma, are discussed. All underwent extensive staging procedures. Retroperitoneal lymph nodes and bone were frequent sites of extratesticular involvement early in the disease. Later widespread dissemination to multiple organs occurred in five of six patients. CNS involvement was a prominent feature of advancing disease. One patient was apparently cured by orchiectomy alone. Although the others exhibited partial responses to chemotherapy and radiation, the disease was fatal to all of them within a year of orchiectomy. Early, aggressive systemic treatment of these patients appears necessary.
Cytomegalovirus in the Pediatric Transplant Recipient (2016)

In Brief A discussion of the retrospective study of Nicastro and colleagues on the use of preemptive cytomegalovirus therapy alone in children after liver transplantation.
A Novel UPLC-MS/MS Method Identifies Organ-Specific Dipeptide Profiles (2021)

Our multi-dipeptide quantification approach demonstrates organ-specific dipeptide distribution. This method allows us to understand more about the dipeptide metabolism in disease or in healthy state.
Raf kinases in signal transduction and interaction with translation machinery (2013)

In recent years, a large amount of evidence has given a central role to translational control in diseases such as cancer, tissue hypertrophy and neurodegeneration. Its deregulation can directly modulate cell cycling, transformation and survival response. The aim of this review is to describe the interaction between Raf activation and the main characters of the translational machinery, such as the elongation factor 1A (eEF1A), which has been recognized in recent years as one of the most interesting putative oncogenes. A particular emphasis is given to an intriguing non-canonical role that eEF1A can play in the relationship between the Ras→Raf-1→MEK1→ERK-1/2 and PI3K→Akt signaling pathways. Recently, our group has described a C-Raf kinase-mediated phosphorylation of eEF1A triggered by a survival pathway induced upon interferon alpha (IFNα) treatment in the human epidermoid cancer cell line (H1355). This phosphorylation seems to be the center of the survival pathway that counteracts the well-known pro-apoptotic function of IFNα. Furthermore, we have identified two new phosphorylation sites on eEF1A (Ser21 and Thr88) that are substrates for Raf kinases in vitro and, likely, in vivo as well. These residues seem to have a significant functional role in the control of cellular processes, such as cell proliferation and survival. In fact, overexpression of eEF1A2 in gemcitabine-treated cancer cells caused the upregulation of phosphoAkt and an increase in cell viability, thereby suggesting that eEF1A2 could exert its oncogenic behavior by participating in the regulation of PI3K pathway.
Hierarchical Control Scheme for two Static Compensators in the Brazilian 45-Bus Power System (2006)

This paper presents a conventional external scheme for controlling two neighboring static compensators (STATCOMs) from a supervisory level. The two STATCOMs are connected to two buses of a load area in a multimachine power system. The power network analyzed in this paper is a 45-bus 10-generator section of the Brazilian power system. Regulating the voltages at the points of connection to the power system is considered to be the primary objective of the local controllers of the two STATCOMs in this study. Based on the deviations of the voltages with respect to their corresponding reference values, the hierarchical control generates the appropriate signals in the form of the auxiliary reference signals for the line voltage control loops in the two devices. Simulation results are provided to show the proposed external controller improves the performance of the power system during small and large scale disturbances
Study of Growth Kinetics of Fe3Se4 Nanocrystallites and the Influence of Size and Shape Tunability on their Magnetic Properties (2021)

Crystalline iron selenide (Fe3Se4) nanoparticles (NPs) present a useful model system for a fundamental understanding of magnetism apart from having potential applications in permanent-magnet-related technologies. Despite significant advancements in understanding of the nucleation and growth processes, control over size and shape tunability is nontrivial, especially for the transition metal chalcogenides (TMC). The Wulff theorem states that if a crystal can grow purely under thermodynamic control of parameters then it will adopt the shape determined by the surface-energy minimization, i.e., the surface energy minimization will drive the growth of each crystalline facet. However, the known or unknown, controllable or uncontrollable parameters of a typical reaction which makes kinetic growth more art than science, depending upon whether we understand them or not. There is hardly any study based on existing models and theories to explain the TMC morphology evolution. In this work, there is a conscious effort to know, understand, and control the individual role of various reaction pathways on the shape and size of the Fe3Se4 nanocrystals. A qualitative growth mechanism is proposed based on the diffusion and reaction processes. Furthermore, the influence of shape/size on the magnetic parameters such as coercivity (HC), magnetization (M60kOe), effective magnetic anisotropy constant (Keff), energy product (BHmax), and average blocking temperature (TB) is investigated for Fe3Se4 NPs. After diving deeper into the science of crystal growth, our insight provides valuable guidance on experimental conditions for the synthesis of Fe3Se4 NPs with tunable sizes/shapes which for the first time can be extended to most TMCs.
Aging and Inflammation in Two Epidemiological Worlds (2008)

Humans evolved in a world with high levels of infection resulting in high mortality across the life span and few survivors to advanced ages. Under such conditions, a strong acute-phase inflammatory response was required for survival; however, inflammatory responses can also promote chronic diseases of aging. We hypothesize that global historical increases in life span at older ages are partly explained by reduced lifetime exposure to infection and subsequent inflammation. To begin a test of this hypothesis, we compare C-reactive protein (CRP); levels in two populations with different epidemiological environments: the Tsimane of Bolivia and persons in the United States. High CRP is significantly more prevalent among the Tsimane up through middle age; by age 35, the Tsimane have spent more years with high CRP than have Americans at age 55. Further testing of the links among infection, inflammation, and chronic diseases of aging among the Tsimane requires collection of age-specific indicators of atherosclerosis and cardiac function.
Refill-Exchange Procedure of the Port Delivery System With Ranibizumab: Overview and Clinical Trial Experience (2022)

The procedure is straightforward but distinct from intravitreal injections and requires adherence to standardized techniques. With appropriate preparation, the procedure can be performed in specific cases. <b>[<i>Ophthalmic Surg Lasers Imaging Retina.</i> 2022;53:257-265.]</b>.
Association of a 76 kDa polypeptide with soluble starch synthase I activity in maize (cv B73) endosperm (1994)

Summary Soluble starch synthase (SSS) I was purified 361‐fold from hand‐dissected endosperm tissue of inbred maize ( Zea mays , cv. B73) to specific activities ranging between 5 and 9 µmol min −1 mg −1 . A key to this purification protocol was the introduction of a size‐exclusion chromatography step, a size‐based fractionation which provided abundant levels of desalted SSS forms I and II. The native molecular masses calculated for SSS forms I and II were 75.5 kDa and 180 kDa, respectively. SSSI was then further purified by hydrophobic interaction chromatography on Phenyl‐Superose and by FPLC on Mono Q. Analysis of column peaks by SDS—PAGE and scanning densitometry revealed that a 76 kDa polypeptide is strongly correlated with SSSI activity. Antibodies were then generated against a 76 kDa polypeptide extracted from starch granules. These antibodies, which were monospecific for the soluble 76 kDa polypeptide, neutralized greater than 90% of SSSI activity, and precipitated the 76 kDa protein. These results establish the 76 kDa protein as an SSSI in the B73 line of inbred maize. An immunologically similar 76 kDa protein also appears to be tightly associated with the starch granule.
Buckling of Woven Fabrics (1990)

The buckling behavior of fabrics initially lying on a horizontal surface has been studied in a three-part series. Parts I and II developed theoretical models that included the effects of fabric weight and nonlinear stiffness properties, respectively. Part III is an experimental study designed to validate the theoretical models. A special apparatus was developed to measure the load-deflection curves of a fabric in buckling. Two materials, a plain weave fabric and a cellulose film, were selected to study the effect of fabric weight and nonlinear bending stiffness on the buckling behavior. The ex perimental results compared favorably with the theoretical predictions. The model that included the fabric weight and realistic nonlinear bending stiffness most accurately represented the actual load-deflection behavior. The model and the experimental results showed that the force to initiate buckling increased dramatically as the weight factor or the nonlinearity of the bending stiffness increased.
Workshop on Dendritic Cells as Natural Adjuvants (2001)

Se propusieron como temas a discutir en futuras reuniones los procedimientos para evaluar de forma segura nuevos adyuvantes y los aspectos regulatorios para su aplicaciUn en humanos, asI como enfatizar en los adyuvantes vacunales que ya estAEn en estudios clInicos. Otro punto interesante sugerido para reuniones futuras fue discutir el uso de citolisinas en el desarrollo de nuevas vacunas como una novedosa aproximaciUn para desviar al sistema inmune hacia la inducciUn de respuesta CTL Investigadores de veintitrOs instituciones acadOmicas y tres compaaeIas farmacOuticas asistieron a la reuniUn, siendo el objetivo mAEs importante de este taller discutir los resultados mAEs actuales en el campo de los adyuvantes y estrechar las relaciones entre los investigadores y compaaeIas dedicadas a la investigaciUn y producciUn de vacunas. El presente reporte estAE estructurado por temas los cuales incluyen una explicaciUn resumida de cada uno elaborada por los presidentes de cada sesiUn seguida de los resœmenes de las presentaciones orales y en carteles. Palabras claves: adyuvantes, inmunologIa, vacunas
Dynamics filter - concept and implementation of online motion generator for human figures (2002)

Humanoid robots are required to make a variety of dynamics and even expressive motions in changing environments. However, the conventional methods for generating humanoid motions fail do achieve this requirement since they can only generate quite artificial and predefined motions through rather complicated optimization processes. In this paper, we propose the concept of "dynamics filter" which transforms a physically inconsistent motion into a consistent one, and provide an example of its implementation using feedback control and local optimization. The optimization is based on the equation of motion of constrained kinematic chains, which is derived from our previously proposed method for computing the dynamics of structure-varying kinematic chains. The proposed method can be applied to online motion generator of humanoid robots.
ChemInform Abstract: Synthesis of Seryl Threonyl Phosphate. A Model Compound Designed to Study the Spectroscopic and Chemical Features of a Phosphodiester Linkage Similar to the One Proposed to Exist in Azotobacter Flavodoxin. (1989)

Abstract The phosphodiester linkage in the title model compound (V) (yield given in g) is very resistant toward alkaline treatment.
Severe Accident Sequence Analysis (1984)

An analysis is presented of key phenomena and scenario which imply some general trends for beyond design-basis-accident in Kori-1 PWR dry containment. The study covers a wide range of severe accident sequences initiated by small break LOCA. The MARCH computer code, with KAERI modifications was used in this analysis. The major emphasis of the paper are two folds, 1) the phenomenologic understanding of severe accident and 2) a study of H2 combustion and debris/ water interactions in a specific small break LOCA for Kori-1 plant. The sensitivity studies for the specific plant data and thermal interaction modelings used in the SASA were performed. The results show that if hydrogen burning does occur at low concentration, the resulting peak pressure does not exceed the design value, while the lower concentration assumption results in repeated burning due to the continuing H generation. For debris/water interaction, the particle size has no effect on the magnitude of peak pressure for the amount of water assumed to be in the reactor cavity. But, the occurrence of peak pressure is considerably delayed in case of using the dryout correlation. The peak containment pressure predicted from the hydrogen combustion and steam pressure spite during full core meltdown scenario does not present a severe threat to the containment integrity.
Complex susceptibility for collisional broadening (1987)

A unified approximate expression for the real part of the susceptibility for collisionally broadened transitions, including line coupling, has been developed. The Hilbert transform has been applied to the impact approximation line shape (Kramers-Kronig relationship) to obtain a result that is applicable from the microwave to the infrared. The approximate function has been compared numerically with the exact result using a newly developed algorithm. The results are applicable to spectral computations of the index of refraction and propagation delays.
Silicon-Germanium-Based Combined MBE and CVD Processing for Vertical "Silicon-on-Nothing" (SON) Device Technology (2004)

A combined molecular beam epitaxy (MBE) / chemical vapor deposition (CVD) processing sequence for the fabrication of vertical fully-depleted and partially-depleted “ silicon-on-Nothing” metal-oxide-semiconductor (MOS) devices is introduced. The key idea is that the transistor channel length as well as depletion width are determined by means of well defined epitaxial deposition in the sub-30nm regime. To obtain the “ silicon-on-nothing” (SON) transistor channel a sacrificial layer made from Si1-xGex and the selective wet-chemical removal of this layer is used. In a first step, this sacrificial layer, grown under biaxial compression by means of MBE, is used for physical channel length definition and to introduce uniaxial strain to the intrinsic silicon channel, grown afterwards by means of CVD. The thickness of the intrinsic Si layer defines the channel depletion width. In a final step the sacrificial Si1-xGex is selectively removed, and the uniaxial strained silicon channel, connecting source and drain, remains free standing.
Techniques for improving CMOS VCO performance (2009)

In this paper, we review some of the well known techniques for improving the performance of CMOS tail current bias LC VCO, such as the phase noise and the tuning range. Based on the better understanding on VCO phase noise mechanism and tuning range limitations, this has lead to newly developed techniques such as noise cancellation VCO and resistively tuned variable inductor, which help improving the VCO performance. The former technique achieves FOM of -186 dBc/Hz while the latter leads to wide tuning range VCO of 56% suitable for tuner application.
A Novel Production of .GAMMA.-Butyrolactone Catalyzed by Homogeneous Ruthenium Complexes. (2000)

γ-Butyrolactone (GBL) is produced by a two-stage hydrogenation of maleic anhydride (MAH) in the liquid phase : a hydrogenation of MAH to succinic anhydride (SAH) in the first stage and a subsequent hydrogenation of SAH to GBL in the second stage. A novel ruthenium catalyst system consisting of Ru salts, trialkylphosphine and p-toluenesulfonic acid (p-TsOH) was found very effective for the hydrogenation of SAH affording GBL in selectivities not less than 95%. Acid promoters like p-TsOH induce structural change in the Ru complexes, leading to the cationic complexes, which show higher catalytic activity and selectivity than the neutral ones. A new process to produce GBL was also developed, in which the features are external preparation of Ru complexes, the reaction protocol which combine over-flow reaction with stripping and the catalyst recovery system by the extraction.
4.-8. März 2019 (2019)

Online dating allows for interactions between users with a high degree of connectivity. This digital form of interaction attracts spammers and scammers, who try to trick users to visit low-class competitors’ websites or steal the users’ money. Fortunately, each attacker leaves a footprint of its actions in the network. It is the task of an Anti-Spam system to detect these and punish the culprit. In this paper, we demonstrate how LOVOO fights such illegal activities using a system of modular, scalable, and fault-tolerant Anti-Spam components. We describe our stream-processing architecture and how it ensures flexibility and facilitates resource-efficient processing of the millions of events produced by hundreds of thousands of users.
Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes (2004)

This study establishes that activation of p38 MAPK by UVB represents a crucial signal required for the conformational change and translocation of Bax to the mitochondria in human keratinocytes. UVB-induced Bax translocation and mitochondrial cytochrome c release, which precede caspase activation and other endpoints of the apoptotic program such as chromatin fragmentation and loss of mitochondrial transmembrane potential, are blocked by genetic or pharmacological inhibition of the p38alpha MAPK. Inhibition of p38 MAPK strongly reduces the UVB-induced formation of sunburn cells and blocks Bax conformational change both in cultured human keratinocytes and in human skin, providing clear evidence for the physiological role of the p38 MAPK-Bax pathway in the removal of precancerous, UVB-damaged keratinocytes. Furthermore, we show that Bcl-2 overexpression, but not the pan-caspase inhibitor zVAD-fmk, blocks Bax conformational change and its subsequent translocation downstream of p38 MAPK. These data indicate that the activation of p38 MAPK by UVB engages a caspase-independent death signal leading to mitochondrial membrane permeabilization and apoptosis in human keratinocytes and suggest that p38 MAPK might have a preventive role in the process of photocarcinogenesis.