gebhart/patrepeval huggingface dataset:
Interaction of the recA protein of Escherichia coli with adenosine 5'-O-(3-thiotriphosphate). (1981)

Incubation of the recA protein of Escherichia coli with the ATP analog adenosine 5'-O-(3-thiotriphosphate) (ATP(gamma S)) in the presence of DNA produces an irreversible inhibition of ATPase activity, although in the presence of ATP, ATP(gamma S) shows an initial competitive inhibition. ATP(gamma S) is not appreciably hydrolyzed by recA protein and the inhibition of ATPase activity is due to the formation of stable complexes which contain equimolar amounts of ATP(gamma S) and recA protein. Formation of stable complexes requires DNA, which is also stably bound to recA protein in the presence of ATP(gammaS), at a ratio of 5 to 10 nucleotides/recA protein monomer. The DNA requirement is satisfied by either single-or double-stranded DNA, and in the latter case, the pH dependence is comparable to that observed for ATP hydrolysis. Binding of ATP(gamma S) is inhibited by other nucleoside di- and triphosphates with efficiencies corresponding to their inhibitory effects on the ATPase activity of recA protein.
Novel optics/micro-optics for miniature imaging systems (2006)

The visual revolution triggered by the commercial application of digital image capturing devices generates the need for new miniaturized and cheap optical imaging systems and cameras. However, in imaging we can observe only a permanent miniaturization of elements but always similar optical principles are applied which are known to the optical designers for many decades. With the newly gained spectrum of technological capabilities it is the time to ask: Which vision principle should be used at which level of miniaturization and which technology has to be applied in order to achieve the perfectly adapted imaging system? In this paper we present an overview of two insect inspired artificial compound eye concepts for compact vision systems fabricated by lithographic technologies, one classical miniaturized objective and its wafer-scale fabrication and the use of variable focal length liquid lenses for miniaturized autofocus- and zoom objectives without moving parts.
Mechanisms of retardation of rigid spherical particles with 3 to 1,085 nm radius in capillary electrophoresis, using buffered polyacrylamide (molecular weight 5 × 106) solutions (1996)

Subjecting particles in the size range of 3 to 1085 nm radius (R) to capillary electrophoresis in buffered solution of entangled uncrosslinked polyacrylamide (M(r) 5 x 10(6)), it was found that particle size-dependent retardation ("molecular sieving") becomes electric field- and particle size range-dependent once the particle size exceeds 15-20 nm in radius. The field strength dependence of the retardation coefficient [KR = d(log mobility)/ d(polymer concentration] and the positive or negative sign of dKR/dR suggest the existence of two different mechanisms of molecular sieving depending on the particle size range: particles with diameters less than the screening length (or blob size) of the polymer network are thought to penetrate into the available spaces within a discontinuous polymer network; particles with diameters larger than the screening length (or blob size) of the polymer network are thought to undergo size-dependent retardation by exerting shear stress against polymer chains, and displacing them, so as to cause local deformations in a continuous polymer network. A limit in the separating capacity of molecular sieving, due to a sharp increase in the rate of band widening with polymer concentration, was found when the value of the retardation coefficient exceeded 60 (mL/g).
Monomer and Excimer Fluorescence of 2-Phenylindole in p-Xylene at 20 °C Studied by Frequency-Domain Fluorometry (1993)

Abstract The effect of 2-phenylindole (2PI) concentration in p-xylene upon the fluorescence decay time was investigated by frequency-domain fluorometry. The fluorescence decay of a dilute (10~ 5 M) 2PI solution in p-xylene at 20 °C is single exponential with the mean decay time t = 1.87 ns and practically independent of the observation wavelength (A obs) in the fluorescence band. The fluores-cence decay in a highly concentrated solution (6 x 10" 3 M) is heterogenic and depends on A obs . For a given modulation frequency (~ 200 Hz), the fluorescence phase shifts at the longwave observation (440-480 nm) distinctly exceed 90°, thus clearly indicating that the observed (excimer) fluorescence results from a process taking place in the excited state. The fluorescence decays were measured at seven values of A obs (360-480 nm), and all the results were analyzed comprehensively (tj and t 2 are equal for all A obs ; the amplitudes are different). The lifetimes of the excimer state is relatively short (~3.5 ns). Radiative (r e) and non-radiative (t,) rate constants for monomer fluorescence of 2PI in p-xylene were determined using appropriate data from photo-and radioluminescence measure-ments.
Influence of extracellular polymeric substances on deposition and redeposition of Pseudomonas aeruginosa to surfaces (2002)

In this study, the role of extracellular polymeric substances (EPS) in the initial adhesion of EPS-producing Pseudomonas aeruginosa SG81 and SG81R1, a non-EPS-producing strain, to substrata with different hydrophobicity was investigated. The release of EPS by SG81 was concurrent with a decrease in surface tension of a bacterial suspension from 70 to 45 mJ m(-2) that was absent for SG81R1. Both strains adhered faster and in higher numbers to a hydrophilic than to a hydrophobic substratum, but the initial deposition rates and numbers of adhering bacteria in a stationary-end point were highest for the non-EPS-producing strain SG81R1, regardless of substratum hydrophobicity. Both strains adhered less to substrata pre-coated with isolated EPS of strain SG81. Furthermore, it was investigated whether bacteria, detached by passing air-bubbles, had left behind 'footprints' with an influence on adhesion of newly redepositing bacteria. Redeposition on glass was highest for non-EPS-producing SG81R1 and decreased linearly with the number of times these cycles of detachment and deposition were repeated to become similar to the redeposition of SG81 after six cycles. This indicates that P. aeruginosa SG81 leaves the substratum surface nearly completely covered with EPS after detachment, while SG81R1 releases only minor amounts of surface active EPS, completely covering the substratum after repeated cycles of detachment and adhesion. Atomic force microscopy showed a thick and irregular EPS layer (up to 32 nm) after the first detachment cycle of EPS-producing strain SG81, whereas the putatively non-EPS-producing strain SG81R1 left a 9 nm thin layer after one cycle. X-ray photoelectron spectroscopy indicated that the bacterial footprints consisted of uronic acids, the prevalence of which increased with the number of detachment and deposition cycles.
Excitonic Materials for Hybrid Solar Cells and Energy Efficient Lighting (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Dinesh Kabra, Li Ping Lu, Yana Vaynzof, Myounghoon Song, Henry J. Snaith, Richard H. Friend; Excitonic Materials for Hybrid Solar Cells and Energy Efficient Lighting. AIP Conference Proceedings 15 July 2011; 1349 (1): 60. https://doi.org/10.1063/1.3605741 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Double parton interactions inγ+3jet andγ+b/cjet+2jet events inpp¯collisions ats=1.96 TeV (2014)

We determine the fraction of events with double parton (DP) scattering in a single $p\overline{p}$ collision at $\sqrt{s}=1.96\text{ }\text{ }\mathrm{TeV}$ in samples of $\ensuremath{\gamma}+3$ jet and $\ensuremath{\gamma}+b/c\text{ }\text{jet}+2$ jet events collected with the D0 detector and corresponding to an integrated luminosity of about $8.7\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$. The DP fractions and effective cross sections (${\ensuremath{\sigma}}_{\text{eff}}$) are measured for both event samples using the same kinematic selections. The measured DP fractions range from 0.21 to 0.17, with effective cross sections in the $\ensuremath{\gamma}+3$ jet and $\ensuremath{\gamma}+b/c\text{jet}+2$ jet samples of ${\ensuremath{\sigma}}_{\text{eff}}^{\text{incl}}=12.7\ifmmode\pm\else\textpm\fi{}0.2(\text{stat})\ifmmode\pm\else\textpm\fi{}1.3(\text{syst})\text{ }\text{ }\mathrm{mb}$ and ${\ensuremath{\sigma}}_{\text{eff}}^{\text{HF}}=14.6\ifmmode\pm\else\textpm\fi{}0.6(\text{stat})\ifmmode\pm\else\textpm\fi{}3.2(\text{syst})\text{ }\text{ }\mathrm{mb}$, respectively.
Asymmetric Allylic Alkylation, an Enabling Methodology (2004)

The diversity of mechanisms for enantiodiscrimination and of bond types that can be formed make Pd-catalyzed asymmetric allylic alkylation a powerful key step for simplification of synthetic strategy to complex molecular targets. Using a wide range of different classes of compounds including alkaloids, polyhydrofurans, nucleosides and carbanucleosides, cyclohexitols and cyclopentitols, chromanes, cyclopentanoids, amino acids, barbiturates, etc., novel synthetic strategies emerge that provide short efficient asymmetric syntheses.
Preparation of a Sulfonated Poly(ether ether ketone)-Based Composite Membrane with Phenyl Isocyanate Treated Sulfonated Graphene Oxide for a Vanadium Redox Flow Battery (2016)

A sulfonated poly(ether ether ketone) (SPEEK)-based composite membrane was developed using functionalized graphene oxide (GO) as the carbon filler for a vanadium redox flow battery. Functionalization of sulfonated GO through phenyl isocyanate treatment (isGO) enabled GO to be dispersed uniformly in the composite membrane, which led to lower vanadium ion permeation. The isGO incorporated SPEEK (SPEEK/isGO) composite membrane exhibited very low vanadium ion permeability (1.0 × 10−7 cm2 min−1), which was approximately eight times lower than that of a Nafion 117 membrane (7.96 × 10−7 cm2 min−1). As a result, the SPEEK/isGO composite membrane showed low discharge capacity decay (19.4%) compared to the Nafion 117 membrane (72.3%) after 200 charge-discharge cycles. This was due to the uniformly dispersed and exfoliated isGO, which acted as a good barrier to prevent vanadium ion crossover through the membrane.
A New High-Temperature Oil-Based Drilling Fluid (1999)

Abstract This paper presents the laboratory development and a field trial of a novel 100% oil base drilling fluid system. In response to the need for a competitive high temperature inhibitive system, lab testing found an oil soluble polymer that imparts high temperature high pressure fluid loss control in a mud system with stable rheology and low formation damage. The polymeric additive is the basis for the 100% oil system, which also has an application in standard invert emulsion systems. The 100% oil system is designed to use mineral or diesel oil as the base. The attributes of the system include inherent inhibition and lubricity from the base oil, a mud weight range of 7.0–18.0 ppg, minimal formation damage, resistance to contamination and maintenance of the HPHT filtration control and rheology during high temperature high pressure applications. Laboratory testing has shown the fluid is temperature stable to 400 °F with diesel or low toxicity mineral oil as the base. This system has been field tested on two wells in Eastern Venezuela. One test was a 6,353', 8 ½" directional interval and the other a 1,053', 5 7/8" horizontal section drilled in near balance conditions with the fluid being nitrogenated to achieve the desired ECD. Both wells were drilled successfully and one well is discussed in this report. This fluid has a wide range of applications evidenced by the documented properties from the lab and the field tests. This paper covers the system formulations, properties, formation damage tests, and the results from the field test.
ChemInform Abstract: Synthesis of Pyridopyrazine‐1,6‐diones from 6‐Hydroxypicolinic Acids via a One‐Pot Coupling/Cyclization Reaction (2013)

Abstract with amino alcohols
Splines for Engineers (1987)

This paper introduces the concept of interpolation consistency. It is claimed that this property is an essential one for splines that are intended for use in Computer Aided Design. Consistency is defined as the property of an interpolation algorithm that, if the given set of points is extended by any point on the interpolated curve, the algorithm applied to the extended set of points will yield exactly the same curve as before. A clear distinction is made between function interpolation, where y is a function of x, and curve interpolation, where x and y are Cartesian coordinates in the geometric plane. The class of consistent curve interpolating planear splines that corresponds to cubic function interpolation is discussed in some detail and includes the Cornu spiral, the lemniscate, and the tension-free mechanical spline. Next the class that corresponds to pentic function interpolation is considered, and an efficient algorithm is presented for the calculation of one such spline, a planar spline where the curvature is a cubic polynomial in the arclength. This algorithm produces curves where the curvature is, loosely speaking, as constant as possible. Some examples illustrating the desirable properties of this spline are given.
Comparison of the distribution of glial fibrillary acidic protein, heat shock protein 60, and hypoxia-inducible factor-1α in retinas from glaucomatous and normal canine eyes (2008)

Results of the study reported here supported a clinically evident, rapidly progressive disease with a shift in cell regulation between acute and chronic glaucoma and also supported ischemia as a mechanism of retinal injury in this disease.
A new cytoplasmic bar-like structure seen in type II alveolar cells of rat lungs. (1980)

Type II alveolar cells from healthy (control) and from pilocarpine-treated rats were studied using transmission electron microscopy of ultra-thin sections and freeze fracture replicas. In freeze-fracture preparations, a bar-like laminated structure about 0.4 micrometer in diameter and 1 similar to or approximately 6 micrometer in length was found in type II alveolar cells; it seemed to be identical to the membrane-bound slits containing electron dense materials which were also observed in ultra-thin sections. The frequency of this structure in the cells increased together with an increase in the number of lamellar bodies after injection of pilocarpine, suggesting a close connection between the bar-like structure and the formation of pulmonary surfactant.
Comparative Protein Expression in Different Strains of the Bloom-forming Cyanobacterium Microcystis aeruginosa (2011)

Toxin production in algal blooms presents a significant problem for the water industry. Of particular concern is microcystin, a potent hepatotoxin produced by the unicellular freshwater species Microcystis aeruginosa. In this study, the proteomes of six toxic and nontoxic strains of M. aeruginosa were analyzed to gain further knowledge in elucidating the role of microcystin production in this microorganism. This represents the first comparative proteomic study in a cyanobacterial species. A large diversity in the protein expression profiles of each strain was observed, with a significant proportion of the identified proteins appearing to be strain-specific. In total, 475 proteins were identified reproducibly and of these, 82 comprised the core proteome of M. aeruginosa. The expression of several hypothetical and unknown proteins, including four possible operons was confirmed. Surprisingly, no proteins were found to be produced only by toxic or nontoxic strains. Quantitative proteome analysis using the label-free normalized spectrum abundance factor approach revealed nine proteins that were differentially expressed between toxic and nontoxic strains. These proteins participate in carbon-nitrogen metabolism and redox balance maintenance and point to an involvement of the global nitrogen regulator NtcA in toxicity. In addition, the switching of a previously inactive toxin-producing strain to microcystin synthesis is reported.
Sparse multivariate polynomial interpolation via the quotient-difference algorithm (2009)

To reconstruct a black box multivariate sparse polynomial from its floating point evaluations, the existing algorithms need to know upper bounds for both the number of terms in the polynomial and the partial degree in each of the variables [2]. On the other hand, Rutishauser's quotient-difference algorithm [7, 3], or the qd-algorithm, is an iterative method that can be use to determine the poles of a meromorphic function from its Taylor coefficients. Combining the relation between the qd-algorithm, Prony's method and their connections to the Ben-Or/Tiwari algorithm [6], we present a new algorithm for reconstructing sparse multivariate polynomials in floating point arithmetic, in which neither the number of terms nor any partial degrees are required in the input [1]. For example, consider the bivariate black box polynomial function, f ( x 1 , x 2 ) = 1/3 x 6/1+4 x 4/2--2.1 x 4/1--4 x 2/2+ x 1 x 2 +4 x 2/1, termed the six-hump camel back function. Evaluate f (x1 , x2 ) at the non-equidistant s-th powers of (1/3, 1/5), in which 3 and 5 are relatively prime, and proceed with the qd-algorithm on the data f (1/3, 1/5), f (1/3 2 , 1/5 2 ), f (1/3 3 , 1/5 3 ), ....The magnitude of the values in the first five e -columns drops from 10 --2 to machine precision, while all values in the sixth e -column are of the order of machine precision. We conclude that the number of terms is 6 and obtain the multi-indices in the support directly from the q -values: 1/q 1 (S) → 9 = 3 2 . 1/q 2 (S) → 25 = 5 2 . 1/q 3 (S) → 625 = 5 4 . 1/q 2 (S) → 15 = 3 1 5 1 . 1/q 1 (S) → 81 = 3 4 . 1/q 1 (S) → 729 = 3 6 . After all six multi-indices in f are known, the coefficients in f can be recovered by a linear system formed by (at least six) evaluations of f . The convergence to zero of some e-columns in the qd-algorithm can be interpreted in an analogous way as the zero discrepancies in the early termination strategy [5, 4]. This is illustrated in Maple. Our sparse interpolation can be extended to polynomials represented in certain non-standard bases [4]. We show an extension to sparse interpolation of polynomials in the Pochhammer basis and present our current research on sparse polynomial interpolation in the Chebyshev basis, both in floating point arithmetic.
Liposomal lidocaine to improve procedural success rates and reduce procedural pain among children: a randomized controlled trial (2005)

Use of liposomal lidocaine was associated with a higher intravenous cannulation success rate, less pain, shorter total procedure time and minor dermal changes among children undergoing cannulation. Its routine use for painful cutaneous procedures should be considered whenever feasible.
Each of the eight simian hemorrhagic fever virus minor structural proteins is functionally important (2021)

The simian hemorrhagic fever virus (SHFV) genome differs from those of other members of the family Arterivirus in encoding two adjacent sets of four minor structural protein open reading frames (ORFs). A stable, full-length, infectious SHFV-LVR cDNA clone was constructed. Virus produced from this clone had replication characteristics similar to those of the parental virus. A subgenomic mRNA was identified for the SHFV ORF previously identified as 2b. As an initial means of analyzing the functional relevance of each of the SHFV minor structural proteins, a set of mutant infectious clones was generated, each with the start codon of one minor structural protein ORF mutated. Different phenotypes were observed for each ortholog of the pairs of minor glycoproteins and all of the eight minor structural proteins were required for the production of infectious extracellular virus indicating that the duplicated sets of SHFV minor structural proteins are not functionally redundant.
Poly(amino ester)‐Based Polymers for Gene and Drug Delivery Systems and Further Application toward Cell Culture System (2021)

Various synthetic polymers based on poly(amino ester) (PAE) are suggested as candidates for gene and drug delivery owing to their pH-responsiveness, which contributes to efficient delivery performance. PAE-based pH-responsive polymers are more biodegradable and hydrophilic than other types of pH-responsive polymers. The functionality of PAE-based polymers can be reinforced by using different chemical modifications to improve the efficiency of gene and drug delivery. Additionally, PAE-based polymers are used in many ways in the biomedical field, such as in transdermal delivery and stem cell culture systems. Here, the recent novel PAE-based polymers designed for gene and drug delivery systems along with their further applications toward adult stem cell culture systems are reviewed. The synthetic tactics are contemplated and pros and cons of each type of polymer are analyzed, and detailed examples of the different types are analyzed.
Aerospace century XXI: Space flight technologies; Proceedings of the Thirty-third Annual AAS International Conference, Boulder, CO, Oct. 26-29, 1986 (1987)

Among the topics discussed are advanced electric propulsion for interplanetary missions, NASA Space Station propulsion, nuclear reactor-based space power systems, electrodynamic tethers for space power and thrust generation, exotic 21st-century spacecraft propulsion, control systems for autonomous operation of the Magellan spacecraft, spacecraft thermal management systems, aerobraking maneuver-related problems, and advanced heavy lift launch vehicles. Also discussed are a space telerobot concept, space-based robotic assembly and maintenance, advanced Al alloys and Al/polymer laminates for aerospace structures, lubrication for space environments, distributed and concurrent computation methods for space structures, and 32-GHz deep space communications.
Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study (2021)

Our study has led us to conclude that LG for AGC is feasible and safe in the general practice of Western institutions when performed by trained surgeons.
Pulmonary arterial hypertension: therapeutic algorithm. (2005)

The numerous controlled clinical trials performed recently in pulmonary arterial hypertension (PAH) can allow us to abandon a clinical-based treatment strategy and adopt an evidence-based therapy. The treatment algorithm is restricted to patients in NYHA class III or IV. The different treatments have been evaluated mainly in sporadic, idiopathic PAH and in PAH associated with scleroderma or to anorexigen use. Extrapolation of these recommendations to other PAH subgroups should be done with caution. High doses of calcium channel blockers are indicated only in the minority of patients who are responders to acute vasoreactivity testing. Patients in NYHA class III should be considered candidates for treatment with either an endothelin receptor antagonist, a prostanoid or a type 5 phosphodiesterase inhibitor. Continuous intravenous administration of epoprostenol is proposed as rescue treatment in NYHA class IV patients. Combination therapy can be attempted in selected cases. Balloon atrial septostomy and/or lung transplantation are indicated for refractory patients or when medical treatments are unavailable.