gebhart/patrepeval huggingface dataset:
An increase in red blood cell distribution width from baseline predicts mortality in patients with severe sepsis or septic shock. (2013)

A potential independent association was recently demonstrated between high red blood cell distribution width (RDW) and the risk of all-cause mortality in critically ill patients, although the mechanism underlying this relationship remains unclear. Little is known about the impact changes in RDW may have on survival in critically ill patients. Therefore, we investigated the prognostic significance of changes in RDW during hospital stay in patients with severe sepsis or septic shock. We prospectively enrolled 329 patients who were admitted to the emergency department (ED) and received a standardized resuscitation algorithm (early-goal directed therapy) for severe sepsis or septic shock. The relationship between the changes in RDW during the first 72 hours after ED admission and all-cause mortality (28-day and 90-day) were analyzed by categorizing the patients into four groups according to baseline RDW value and ΔRDW72hr-adm (RDW at 72 hours – RDW at baseline). The 28-day and 90-day mortality rates were 10% and 14.6%, respectively. Patients with increased RDW at baseline and ΔRDW72hr-adm >0.2% exhibited the highest risks of 28-day and 90-day mortality, whereas the patients with normal RDW level at baseline and ΔRDW72hr-adm ≤0.2% (the reference group) had the lowest mortality risks. For 90-day mortality, a significantly higher mortality risk was observed in the patients whose RDW increased within 72 hours of ED admission (normal RDW at baseline and ΔRDW72hr-adm >0.2%), compared to the reference group. These associations remained unaltered even after adjusting for age, sex, Sequential Organ Failure Assessment (SOFA) score, Charlson Comorbidity Index, renal replacement therapy, albumin, hemoglobin, lactate, C-reactive protein and infection sites in multivariable models. We found that an increase in RDW from baseline during the first 72 hours after hospitalization is significantly associated with adverse clinical outcomes. Therefore, a combination of baseline RDW value and an increase in RDW can be a promising independent prognostic marker in patients with severe sepsis or septic shock.
MAC scheduling for uplink transmission in UMTS WCDMA (2002)

Scheduling issues in the medium access control (MAC) layer in an UTMS radio network are presented and analyzed. Several scheduling algorithms are therefore proposed. Their performance has been tested with the help of an MAC simulator. The simulator involves MAC protocol functions and parts of the physical and radio link control (RLC) layer radio interface protocols. In order to assess the impact of the proposed algorithms on the overall system behavior, a number of procedures located in the network side of a WCDMA radio network are included in the simulator. The uplink transmission is considered in the simulations done. An evaluation of scheduling algorithms for dedicated channels is performed; results are shown and analyzed.
The Evidence for the Use of Growth Factors and Active Skin Substitutes for the Treatment of Non-Infected Diabetic Foot Ulcers (DFU): A Health Technology Assessment (HTA) (2011)

Add-on therapy with growth factors and active skin substitutes for treating uncomplicated DFU could be an alternative to SWC alone. For explicit recommendations further studies with stronger evidence are necessary.
Effect of probiotic treatment on the clinical course, intestinal microbiome, and toxigenic Clostridium perfringens in dogs with acute hemorrhagic diarrhea (2018)

The probiotic treatment was associated with an accelerated normalization of the intestinal microbiome. Dogs with aseptic AHDS showed a rapid decrease of netF toxin genes and fast clinical recovery in both groups under symptomatic treatment without antibiotics.
Supplementary Table from Detecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis (2023)

Supplementary Table from Detecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis
Modulation of drug resistance in homoharringtonine‐resistant C‐1300 neuroblastoma cells with cyclosporine A and dipyridamole (1991)

The development of resistance accounts for therapy failure in the majority of advanced cases of neuroblastoma in children. A new transplantable murine C-1300 neuroblastoma cell line was developed in vitro, by repeated exposure of a sensitive cell line to increasing, but sublethal, doses of Homoharringtonine (HHT). The ED50 of the highly resistant cells for HHT, using a standard agar colony assay, is 480 ng/ml, compared with 13 ng/ml for the sensitive parental line. The resistant cells have cross-resistance to a number of other agents, including adriamycin, vinca alkaloids, melphalan, and CCNU. Western blot analysis revealed progressive increases in P-glycoprotein, parallel to the graded development of resistance with a 29-fold elevation in the highest resistant cells. High-performance liquid chromatography (HPLC) indicated that resistant cells have a significantly lower uptake of HHT than parental sensitive cells. cyclosporine A (CsA) and dipyridamole (DPM) could modulate the acquired resistance and completely restore the cytotoxic effects of HHT and adriamycin as determined by the clonogenic assay. The reversal of resistance by CsA and DPM was dose dependent. With the relative low toxicity of dipyridamole and CsA in doses required for modulation of resistance, these agents may be candidates for clinical utilization in chemotherapy of resistant neuroblastoma.
Functional genomic analyses highlights a shift in Gpr17 -regulated cellular processes in oligodendrocyte progenitor cells (OPC) and underlying myelin dysregulation in the aged forebrain (2020)

Summary Brain aging is characterised by a decline in neuronal function and associated cognitive deficits. There is increasing evidence that myelin disruption is an important factor that contributes to the age-related loss of brain plasticity and repair responses. In the brain, myelin is produced by oligodendrocytes, which are generated throughout life by oligodendrocyte progenitor cells (OPCs). Currently, a leading hypothesis points to aging as a major reason for the ultimate breakdown of remyelination in Multiple Sclerosis (MS). However, an incomplete understanding of the cellular and molecular processes underlying brain aging hinders the development of regenerative strategies. Here, our combined systems biology and neurobiological approach demonstrates that oligodendroglial and myelin genes are amongst the most altered in the aging mouse cortex. This was underscored by the identification of causal links between signaling pathways and their downstream transcriptional networks that define oligodendroglial disruption in aging. The results highlighted that the G-protein coupled receptor GPR17 is central to the disruption of OPC in aging and this was confirmed by genetic fate mapping and cellular analyses. Finally, we used systems biology strategies to identify therapeutic agents that rejuvenate OPC and restore myelination in age-related neuropathological contexts.
The future of genomics in pathology (2012)

The recent advances in technology and the promise of cheap and fast whole genomic data offer the possibility to revolutionise the discipline of pathology. This should allow pathologists in the near future to diagnose disease rapidly and early to change its course, and to tailor treatment programs to the individual. This review outlines some of these technical advances and the changes needed to make this revolution a reality.
Endoscopic ultrasound-guided fine-needle aspiration biopsy for lymphadenopathy of unknown origin (2006)

Open thoracic surgery, laparotomy, and other invasive diagnostic procedures such as mediastinoscopy and laparoscopy can now be avoided, as EUS-FNAB is potentially a safe and accurate tool for diagnosing unknown lymphadenopathy, including lymphoma.
Poor lung function and associated patterns of cognitive decline (2011)

Click here to view the accompanying paper in this issue.
Natural Language Interfaces for Data Analysis with Visualization: Considering What Has and Could Be Asked (2017)

Natural language is emerging as a promising interaction paradigm for data analysis with visualization. Designing and implementing Natural Language Interfaces (NLIs) is a challenging task, however. In addition to being able to process and understand natural language expressions, NLIs for data visuailzation must consider other factors including input modalities, providing input affordances, and explaining system results, among others. In this article, we examine existing NLIs for data analysis with visualization, and compare and contrast them based on the tasks they allow people to perform. We discuss open research opportunities and themes for emerging NLIs in the visualization community. We also provide examples from the existing literature in the broader HCI community that may help explore some of the highlighted themes for future work. Our goal is to assist readers to understand the subtleties and challenges in designing NLIs and encourage the community to think further about NLIs for data analysis with visualization.
Metabolomic changes in CSF of migraine patients measured with 1H-NMR spectroscopy (2016)

Using an exploratory <sup>1</sup>H-NMR metabolomics analysis we identified metabolites that were able to discriminate hemiplegic migraine patients from healthy controls. The lower levels of 2-hydroxybutyrate found in patients with hemiplegic migraine could indicate a dysregulation of the brain's energy metabolism. An experimental confirmation in vitro or in animal models will be required to confirm or discard this hypothesis. Migraine with and migraine without aura patients did not reveal a metabolic profile different from healthy controls.
Collision Cross Sections of 400- to 1800-keVH3+Ions in Collisions withH2andN2Gases and Li Vapor (1973)

Cross-section measurements of the dissociation modes $\mathrm{H}_{3}^{}{}_{}{}^{+}$ \ensuremath{\rightarrow} (3H and H + ${\mathrm{H}}_{2}$), H + $\mathrm{H}_{2}^{}{}_{}{}^{+}$, ${\mathrm{H}}^{+}$ + 2H, ${\mathrm{H}}^{+}$ + ${\mathrm{H}}_{2}$, H + 2${\mathrm{H}}^{+}$, ${\mathrm{H}}^{+}$ + $\mathrm{H}_{2}^{}{}_{}{}^{+}$, and 3${\mathrm{H}}^{+}$ are reported for $\mathrm{H}_{3}^{}{}_{}{}^{+}$ energies between 400 and 1800 keV in targets of ${\mathrm{H}}_{2}$, ${\mathrm{N}}_{2}$, and Li. For the ${\mathrm{H}}_{2}$ target, comparisons are made with available previous measurements of H, ${\mathrm{H}}^{+}$, ${\mathrm{H}}_{2}$, and $\mathrm{H}_{2}^{}{}_{}{}^{+}$ production cross sections at lower energies. Cross-section measurements for 270- to 1200-keV ${\mathrm{H}}_{2}$ \ensuremath{\rightarrow} $\mathrm{H}_{2}^{}{}_{}{}^{+}$, H + ${\mathrm{H}}^{+}$, and 2${\mathrm{H}}^{+}$ are also reported.
Supplementary Figure 6 from ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals (2023)

&lt;p&gt;PDF file, 75K, The role of ALKBH3 in progression of human urinary bladder cancer. ALKBH3 contributes to cancer cell survival, angiogenesis and invasion through manipulating upregulating NOX2-ROS signal and Tweak/Fn14-VEGF signal in not only cancer cells but also endothelial cells.&lt;/p&gt;
The very hungry bactericidal antibiotics (2022)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Frame-adaptive techniques for quality versus efficiency tradeoffs in STFT analysis (2002)

In this paper, we present techniques for computing frame-adaptive approximations to the STFT which can satisfy arbitrarily specified bounds on the number of arithmetic operations per frame. The central idea is to represent the samples in each signal frame with a very small number Q of quantization levels, yielding an SNR of 10Iog(Q/sup 2/) dB. This leads to the formulation of the frame's DFT computation as a process of summation among pre-stored vectors. Experimental studies are used to propose and verify mathematical models for how the number of vector additions needed in this process depends on the frequency content of a frame. The models are utilized to design frame-adaptive techniques for excluding various subsets of vector elements from the summation process in order to keep the number of additions per frame from exceeding any specified bound, B.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Functional Cross-talk between Fatty Acid Synthesis and Nonribosomal Peptide Synthesis in Quinoxaline Antibiotic-producing Streptomycetes (2004)

Quinoxaline antibiotics are chromopeptide lactones embracing the two families of triostins and quinomycins, each having characteristic sulfur-containing cross-bridges. Interest in these compounds stems from their antineoplastic activities and their specific binding to DNA via bifunctional intercalation of the twin chromophores represented by quinoxaline-2-carboxylic acid (QA). Enzymatic analysis of triostin A-producing Streptomyces triostinicus and quinomycin A-producing Streptomyces echinatus revealed four nonribosomal peptide synthetase modules for the assembly of the quinoxalinoyl tetrapeptide backbone of the quinoxaline antibiotics. The modules were contained in three protein fractions, referred to as triostin synthetases (TrsII, III, and IV). TrsII is a 245-kDa bimodular nonribosomal peptide synthetase activating as thioesters for both serine and alanine, the first two amino acids of the quinoxalinoyl tetrapeptide chain. TrsIII, represented by a protein of 250 kDa, activates cysteine as a thioester. TrsIV, an unstable protein of apparent Mr about 280,000, was identified by its ability to activate and N-methylate valine, the last amino acid. QA, the chromophore, was shown to be recruited by a free-standing adenylation domain, TrsI, in conjunction with a QA-binding protein, AcpPSE. Cloning of the gene for the QA-binding protein revealed that it is the fatty acyl carrier protein, AcpPSE, of the fatty acid synthase of S. echinatus and S. triostinicus. Analysis of the acylation reaction of AcpPSE by TrsI along with other A-domains and the aroyl carrier protein AcmACP from actinomycin biosynthesis revealed a specific requirement for AcpPSE in the activation and also in the condensation of QA with serine in the initiation step of QA tetrapeptide assembly on TrsII. These data show for the first time a functional interaction between nonribosomal peptide synthesis and fatty acid synthesis.
Editorial - 10th Solid State Dosimetry Conference (1993)

Journal Article Editorial - 10th Solid State Dosimetry Conference Get access S.W.S. McKeever, S.W.S. McKeever Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Scharmann A. Scharmann Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 47, Issue 1-4, 1 May 1993, Pages 0v–xvii, https://doi.org/10.1093/oxfordjournals.rpd.a081693 Published: 01 May 1993
Inlet ionization: protein analyses from the solid state without the use of a voltage or a laser producing up to 67 charges on the 66 kDa BSA protein (2011)

Additional supporting information may be found in the online version of this article. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Discriminative auditory features for robust speech recognition (2002)

Recently, Li et al. proposed a new auditory feature for robust speech recognition in noise environments.The new feature was derived by mimicking closely the function of human auditory process.Several filters were used to model the outer ear, middle ear, and cochlea, and the initial filter parameters and shapes were obtained from crude psychoacoustics results, experience, or experiments.Although one may adjust the feature parameters by hand to get better performance, the resulting feature parameters still may not be optimal in the sense of minimal recognition errors, especially for different tasks.To further improve the auditory feature, in this paper we apply discriminative training to optimize the auditory feature parameters with some guidance from psychoacoustic evidence but otherwise in a data-driven approach so as to minimize the recognition errors.One significant contribution over similar efforts in the past, such as discriminative feature extraction, is that we make no assumption on the parametric form of the auditory filters.Instead, we only require the filters to be smooth and triangular-like as suggested by psychoacoustics research.Our approach is evaluated on the Aurora database and achieves a word error reduction of 19.2%.
Foaming Agents for Powder Metallurgy Production of Aluminum Foam (2011)

Metallic foams are commonly produced using hydride foaming agents. Carbonates are safer to handle than hydrides; however, their use in the powder metallurgy (PM) route to obtaining a fine and homogenous cell structure has not been evaluated. In this study, carbonates and hydroxides were investigated as foaming agents for the production of Al-Si-Cu alloy foams by the PM route. The thermal decomposition behavior of the foaming agents was evaluated in conjunction with the cell structure of the aluminum foams produced. From the results, it was clarified that a foaming agent that began decomposing after the matrix melted is required to obtain a fine and homogenous cell structure. The TiH2 foam formed under similar conditions was obviously different and had a coarse and rounded cell structure. MgCO3 and CaMg(CO3)2 were selected as suitable foaming agents for the Al-Si-Cu alloy. Once expanded, the CaMg(CO3)2 foam had a specific gravity of 1.19 and a homogeneous, fine and spherical cell structure.
Single cell transcriptome analysis reveals human prostate cancer cells upregulate retinoic acid signalling in response to androgen withdrawal (2019)

Searchable abstracts of presentations at key conferences in oncology ISSN 2631-4657 (online)
Fabrication of nanoporous membranes through silicon templates : two different approaches (2016)

We present here a novel approach to fabricate nanoporous membranes based on the use of sacrificial template structures to individually define pore parameters such as geometry, shape, and placement. Based on this rationale two different nano-fabrication methods were developed; one resulting in conical multilayered nanopores arrays with openings with critical dimensions down to 60 nm; and a second one resulting in high aspect ratio nanopores with diameters down to 17 nm and 1 Î¼m length. The presented methods are relevant for the fields of nanofabrication and nanofluidics since they extend the shapes, geometries and materials into which nanoporous membranes can be obtained.
The arc-fault circuit interrupter, an emerging product (2002)

The arc-fault circuit interrupter (AFCI) is beginning to emerge as a new product in residential power system applications in the United States to protect against conditions that may cause fire. This paper provides some of the background regarding its emergence as a product and the function it is intended to provide. The evolving technology may also lend itself to industrial applications, as the potential applications become sufficiently well understood.
Multi-Modal Calibration of Surveillance Sensor Networks (2006)

Target detection and localization is one of the key research challenges in sensor networks. In this paper we propose a heterogeneous wireless sensor network integrating imaging and non-imaging sensors to accomplish the detection and localization task in complex urban environments. The low-cost non-imaging sensors provide early detection and partial localization of potential targets and direct imaging sensors to focus on them. Accurate target location estimated by the imaging sensors is subsequently used for in-situ calibration of the non-imaging sensors so that localization error is minimized over time. We evaluate our approach through simulation and our preliminary results reveal that coordination across different sensing modalities increases localization accuracy and can reduce the amount of imaging data that must be carried by the network.
Clinical correlation with codon-specific mutations in metastatic colorectal cancer. (2016)

3596 Background: Mutational status in colorectal cancer (CRC) impacts response to EGFR inhibition, prognosis, and may affect response to chemoradiation. It is unclear if obesity or other clinical characteristics, including smoking and diabetes, increases the predilection for certain genotypes. The purpose of the following study was to explore the relationship between clinical factors, codon-specific mutations and overall survival (OS). Methods: Metastatic colorectal cancer patients were retrospectively analyzed; clinical characteristics including smoking, diabetes, and body mass index (BMI) were extracted from medical records. Genotyping was performed for > 150 mutations across 15 commonly mutated cancer genes including NRAS, KRAS, PIK3CA, BRAF, and PTEN as part of their clinical management and recorded. Logistic regression was used to establish associations between clinical characteristics and genotypes. Results: 394 metastatic CRC patients were identified. Median age was 58 (range 25-89). 219 (56%) were male. 202 (51%) were non-smokers. 61 had diabetes. 272 patients had a BMI ≥ 25. 136 patients had KRAS mutations, the most common of which was G12D (37%). Diabetes was associated with a higher incidence of KRAS (odds ratio [OR] 1.9 95% CI 1.1-1.3; p = 0.02) and PIK3CA mutations (OR 2.4 95% CI 1.1-5.0; p = 0.02), but not OS. KRAS mutations were not significantly associated with BMI ≥ 25 nor OS. BRAF mutations were significantly associated with poorer OS (hazard ratio [HR] 1.9 95% CI 1.3-2.7; p < 0.001). Current smokers were more likely to have CTNNB1 mutations (OR 11.3 95% CI 1.5-83.2; p = 0.02) and G12D KRAS mutations (OR 5.6 95% CI 1.0-30.3). Current smokers were less likely to have BMI ≥ 25 (OR 0.44; p = 0.02). Patients with BMI ≤ 18.5 have an association with poor OS (HR 2.6 95% CI 1.1-6.4; p = 0.03), although this needs to be corroborated with a larger sample size. Conclusions: A statistically significant association was found between diabetes and KRAS and PIK3CA mutations. The association of BRAF mutations and decreased overall survival was significant, concordant with previous reports. Smokers were more likely to harbor G12D KRAS mutations, and low BMI (≤ 18.5) trended toward poorer overall survival.
Daytime Variations in Alertness/Drowsiness and Vigilance in Narcolepsy/Cataplexy (2006)

This paper concerns four aspects of the daily variations encountered both in daytime alertness/drowsiness levels and in so-called psychomotor vigilance in narcolepsycataplexy. They are: (i) the physiological changes used as measures of alertness/ drowsiness; (ii) the issue of whether or not qualitatively different forms of sleepiness and drowsiness exist; (iii) the effects of the variations in alertness/drowsiness upon sensitive performance tasks, in particular on so-called vigilance tests; and (iv) the underlying mechanism(s) of drowsiness in narcolepsy. The word drowsiness is generally employed rather than sleepiness, as it denotes an objective physiological state, whereas sleepiness has a much broader and less precise meaning.