gebhart/patrepeval huggingface dataset:
Age‐associated reduction of cellular spreading/mechanical force up‐regulates matrix metalloproteinase‐1 expression and collagen fibril fragmentation via c‐Jun/AP‐1 in human dermal fibroblasts (2014)

The dermal compartment of human skin is largely composed of dense collagen-rich fibrils, which provide structural and mechanical support. Skin dermal fibroblasts, the major collagen-producing cells, are interact with collagen fibrils to maintain cell spreading and mechanical force for function. A characteristic feature of aged human skin is fragmentation of collagen fibrils, which is initiated by matrix metalloproteinase 1 (MMP-1). Fragmentation impairs fibroblast attachment and thereby reduces spreading. Here, we investigated the relationship among fibroblast spreading, mechanical force, MMP-1 expression, and collagen fibril fragmentation. Reduced fibroblast spreading due to cytoskeletal disruption was associated with reduced cellular mechanical force, as determined by atomic force microscopy. These reductions substantially induced MMP-1 expression, which led to collagen fibril fragmentation and disorganization in three-dimensional collagen lattices. Constraining fibroblast size by culturing on slides coated with collagen micropatterns also significantly induced MMP-1 expression. Reduced spreading/mechanical force induced transcription factor c-Jun and its binding to a canonical AP-1 binding site in the MMP-1 proximal promoter. Blocking c-Jun function with dominant negative mutant c-Jun significantly reduced induction of MMP-1 expression in response to reduced spreading/mechanical force. Furthermore, restoration of fibroblast spreading/mechanical force led to decline of c-Jun and MMP-1 levels and eliminated collagen fibril fragmentation and disorganization. These data reveal a novel mechanism by which alteration of fibroblast shape/mechanical force regulates c-Jun/AP-1-dependent expression of MMP-1 and consequent collagen fibril fragmentation. This mechanism provides a foundation for understanding the cellular and molecular basis of age-related collagen fragmentation in human skin.
Maintaining safe memory for security, debugging, and multi-threading (2006)

As transistor budgets grow enabling chip multi-core processors, adding hardware support to ensure the correctness and security of programs will be just as important, for the average user, as adding another core. The goal of our research is to develop hardware support for software checks and for multi-threaded synchronization that protects memory from corruption. This is the source of a significant number of bugs and security issues. We want efficient low-overhead run-time performance of these checks and synchronization so that it can be left on all of the time, even in production code releases. 
Bounds checking protects pointer and array accesses. It is the process of keeping track of the address boundaries for objects, and checking that the loads and stores do not stray outside bounds. It can serve two purposes: it can assist debugging by precisely capturing invalid memory accesses, and it can guarantee protection against buffer overflow attacks. Unfortunately, the high performance overhead of runtime bounds checking has prevented its inclusion in most released software. In this thesis, we analyze the sources of bounds checking overhead. We then consider hardware/software enhancements: the effect merging the check into a single instruction, software optimizations based on potential for overflow to eliminate checks, and changes to meta-data layout to limit copying overhead. 
Transactional Memories enable programmers to greatly simplify multi-threaded code by eliminating lock synchronization and its attending deadlock and livelock problems. Unlike locks they also enable speculative concurrent execution through the critical section. Specialized transactional memory can also aid concurrent programming models by providing determinism only when needed at run-time. A key limitation of past transactional memory proposals are that they have a finite memory capacity. Virtualized transactional memory (unbounded in space and time) are desirable, as they can increase the scope of transactions' use, and thereby further simplify a programmer's job. In this thesis, we introduce Page-based Transactional Memory to support unbounded transactions. We combine transaction bookkeeping with the virtual memory system to support fast transaction conflict detection, commit, abort, and to maintain transactions' speculative data.
Integrated systems for oilfield produced water treatment: The state of the art (2016)

Produced water (PW) is considered as one of the largest waste streams in the petroleum, oil, and gas industry. The drilling and extraction operations aiming to maximize the production of oil may be counterbalanced by the huge production of contaminated water with pollutants, such as heavy metals and organic compounds. This review provides insight into the implementation of different technologies in the petroleum industry for treating PW generated from conventional oilfields in upstream and downstream processes. Scientific efforts in the future can concentrate on developing the most economical and environmentally compliant solutions for the management of untreated PW.
Synthesis of (±)-Annonelliptine and (±)-Anomoline (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (±)-Annonelliptine and (±)-AnomolineChi-Ming Chen, Yu-Fei Fu, and Tsang-Hsiung YangCite this: J. Nat. Prod. 1995, 58, 11, 1767–1771Publication Date (Print):November 1, 1995Publication History Published online1 July 2004Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/np50125a022https://doi.org/10.1021/np50125a022research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Definitions of histocompatibility typing terms: Harmonization of Histocompatibility Typing Terms Working Group (2011)

Histocompatibility testing for stem cell and solid organ transplantation has become increasingly complex as newly discovered human leukocyte antigen (HLA) alleles are described. HLA typing assignments reported by laboratories are used by physicians and donor registries for matching donors and recipients. To communicate effectively, a common language for histocompatibility terms should be established. In early 2010, representatives from clinical, registry, and histocompatibility organizations joined together as the Harmonization of Histocompatibility Typing Terms Working Group to define a consensual language for laboratories, physicians and registries to communicate histocompatibility typing information. The Working Group defined terms for HLA typing resolution, HLA matching and a format for reporting HLA assignments. In addition, definitions of verification typing and extended typing were addressed. The original draft of the Definitions of Histocompatibility Typing Terms was disseminated to colleagues from each organization to gain feedback and create a collaborative document. Commentary gathered during this 90-day review period were discussed and implemented for preparation of this report. Histocompatibility testing continues to evolve thus, the definitions agreed upon today, likely will require refinement and perhaps additional terminology in the future.
Engineered polymer matrix novel biocompatible materials decorated with eucalyptus oil and zinc nitrate with superior mechanical and bone forming abilities (2022)

Electrospun scaffolds based on polymer-matrix composites have gained wide attention recently. A novel engineered biocompatible scaffold is manufactured using polyurethane (PU) loaded with eucalyptus oil (EL) and Zinc nitrate (ZnNO3) using the electrospinning technique. Morphological observations revealed the reduced fibre diameter for the PU/EL and PU/EL/ZnNO3 compared to PU. Contact angle studies indicated the increase in hydrophobic behaviour of the PU/EL whereas an increase in wettability for PU/EL/ZnNO3 compared to PU. EL and ZnNO3 presence in the PU matrix enhanced the mechanical strength. Surface topology analysis showed a decrease in the roughness for the PU/EL and PU/EL/ZnNO3 compared to the pristine PU. Both PU/EL and PU/EL/ZnNO3 showed prolonged clotting time and decreased haemolytic percentage compared to the polyurethane as indicated in their anticoagulation studies. In vitro bone mineralisation testing depicted the increase in calcium deposition for the modified PU samples compared to pure polyurethane sample. Hence, PU/EL and PU/EL/ZnNO3 scaffold with superior properties render full avenues for new bone generation.
Wet vs Dry Gas Cleaning In the Steel Industry (1968)

Deciding whether the gas should be cleaned by a “dry” system or a “wet” system requires a full consideration of all factors of which the capital cost is only one. Anticipating the various problems which might be expected and designing adequate measures for each calls for major engineering effort,but onlythen can a best choice be made. The principles which govern the above are illustrated by a typical selection of gas cleaning equipment to be used as part of a BOF steel making installation. Two entirely different gas cleaning systems are presently in BOF service in North America. Both will do an excellent job if properly designed. Either system will cost in excess of $2,000,000 and will require careful control and large amounts of electrical power. One system, the dry electrostatic precipitator, requires humidification of the gas; protection against explosions; elaborate electrical controls, insulators, etc.; and a rugged handling system for the bone dry dust collected. The other system, wet washing with water, Is easier to control but uses large quantities of water and electric power. As in the case of the “dry” system, handling the dirt collected is a difficult problem requiring careful study and choice of equipment. In either case the dust may be discarded or reused, but it must be handled with care lest it become an air or stream pollution problem all over again.
Epidemiology and burden of alopecia areata: a systematic review (2015)

AA is the most prevalent autoimmune disorder and the second most prevalent hair loss disorder after androgenetic alopecia, and the lifetime risk in the global population is approximately 2%. AA is associated with psychiatric and medical comorbidities including depression, anxiety, and several autoimmune disorders, and an increased global burden of disease.
Physiological prediction of genetic merit for female reproduction in the sheep. (1988)

National audience
Visual surveillance for moving vehicles (2002)

An overview is given of a novel vision system for locating, recognising and tracking multiple vehicles, using a single monocular camera mounted on a moving vehicle. 3D model-based techniques are employed to obtain detailed information about vehicle movements. Egomotion estimation is performed by inter-frame tracking of features on the ground plane. Vehicle detection and hypothesis generation is performed using a template correlation technique. Once detected and identified, vehicles are tracked using dynamic filtering. The resulting information about 3D vehicle motions is passed to a collision alert system which can warn the driver of potential hazards. The overall approach is demonstrated on a typical motorway image sequence.
Growth model and the effect of CuO nanocrystallites on the properties of chemically derived epitaxial thin films of YBa2Cu3O7−x (2002)

In metalorganic deposition using trifluoroacetates (TFA-MOD), CuO nanocrystallites in calcined film, which influence the critical current density (Jc) of the resulting film, have seldom been considered before. CuO nanocrystallites ripen and grow during the calcining process at 200–250 °C and grow into large CuO grains in the YBa2Cu3O7-x (YBCO) film. The final diameter of the grains is about 0.1 μm. When highly purified coating solution is used, suppressing the creation of nanocrystallites in the precursor film is an effective way to obtain high-Jc YBCO film because the nanocrystallites consist only of CuO. We obtained the highest-Jc YBCO film on LaAlO3 single crystal with a calcining process of 9h43m at 200–250 °C. It was 141 nm thick and had a Jc of 7.5 MA/cm2 (77 K, 0 T), as measured by the four-probe method. The firing process of TFA-MOD still has several unsolved problems; why can H2O and HF gas diffuse quickly within the film? These phenomena can be explained by a model with a quasiliquid consisting of Y, Ba, Cu, O, H, and F. The H2O and HF can move quickly in the quasiliquid network within the film during the firing process. According to the model, we can get more conversion of CuO nanocrystallites into quasiliquid by increasing the amount of water vapor. Jc of the film was increased from 3.3 to 4.5 MA/cm2 (77 K, 0 T) by increasing the humidity from 4.2% to 12.1% during the long calcining profile of 66h40m at 200–250 °C. These results confirm the above model. CuO nanocrystallites in precursor films induce nonstoichiometric metal contents in the quasiliquid. Isolated CuO grains in YBCO film indirectly cause nonstoichiometric quasiliquid in other areas. Such nonstoichiometric quasiliquid leads to non-YBCO materials such as BaO, Y2O3, and Y2Cu2O5. Thus, films derived from non-highly purified coating solution and ones prepared with an inappropriate calcining process both have lower Jc values. Micrographs obtained by transmission electron microscopy and Jc results support this hypothesis.
Flow cytometry of oesophageal mucosal biopsies; epidermal growth factor receptor, and CD15 (1992)

Flow cytometry may be used to examine the properties of single or isolated cells. We have shown that it is possible to disaggregate and label oesophageal epithelial cells for two surface markers, CD15 and epidermal growth factor receptor. We have previously demonstrated these markers in oesophageal squamous cells using immunoperoxidase techniques. These labelled disaggregated cells could then be measured by flow cytometry.
Neurologic Sequelae After Interscalene Brachial Plexus Block for Shoulder/Upper Arm Surgery: The Association of Patient, Anesthetic, and Surgical Factors to the Incidence and Clinical Course (2005)

We determined the incidence, distribution, and resolution of neurologic sequelae and the association with anesthetic, surgical, and patient factors after single-injection interscalene block (ISB) using levobupivacaine 0.625% with epinephrine 1:200,000 in subjects undergoing shoulder or upper arm surgery, or both, in 693 consecutive adult patients. After a standardized ISB, assessments were made at 24 and 48 h and at 2 and 4 wk for anesthesia, hypesthesia, paresthesias, pain/dysesthesias, and motor weakness. Symptomatic patients were monitored until resolution. Subjects reporting pain or discomfort >3 of 10 and those with motor or extending sensory symptoms received diagnostic assessment. Six-hundred-sixty subjects completed 4 wk of follow-up. Fifty-eight neurologic sequelae were reported by 56 subjects. Symptoms were sensory except for two cases of motor weakness (lesions identified distant from the ISB site). Thirty-one sequelae with likely ISB association were reported by 29 subjects, including 14 at the ISB site, 9 at the distal phalanx of thumb/index finger, 7 involving the posterior auricular nerve, and 1 clinical brachial plexopathy. Sequelae not likely associated with the ISB were reported by 27 subjects with symptoms reported in the median (n = 9) and ulnar (n = 4) nerves, surgical neuropraxias (n = 12), and motor weakness (n = 2). Symptoms resolved spontaneously (median 4 wk; range, 2-16 wk) except in the two patients with motor weaknesses and the patient with clinical brachial plexopathy, who received therapeutic interventions. Variables identified as independent predictors of neurologic sequelae likely related to ISB were paresthesia at needle insertion and ISB site pain or bruising at 24 h. In contrast, surgery preformed in the sitting position, as well as ISB site bruising, was identified as a predictor of neurologic sequelae not likely related to ISB. In conclusion, neurologic sequelae after single-injection ISB using epinephrine mainly involve transient minor sensory symptoms.
Merging Multiple Formations: A Meta-Formation Prospective (2006)

This paper considers the problem of merging of more than two (minimally) rigid formations which do not have any common agent to obtain a single (minimally) rigid formation in R2 and R3. Following previously developed strategies for sequential merging of two rigid formations, a new set of enhanced merging operations is developed. They can be performed in a formalized meta-formation framework, where the individual rigid formations are considered as meta-vertices and they can be merged into a meta-formation. These operations for growing meta-formations offer a level of control to the merging quality and optimality, in the sense of minimizing the number of meta-edges (that is, edges between different meta-vertices) required. It is also proved that all minimally rigid meta-formations in R2 can be obtained by successively merging two or more meta-vertices using the proposed set of meta-operations.
Familial motor neuron diseases other than amyotrophic lateral sclerosis (2021)

This chapter discusses non-amyotrophic lateral sclerosis (ALS) forms of motor neuron degeneration that have a genetic basis. The conditions covered include the spinal muscular atrophies (SMAs), the hereditary motor neuropathies (HMNs), Kennedy’s disease and the hereditary spastic paraplegias (HSPs). SMA was first described independently by Werdnig and Hoffman in 1891. The term SMA encompasses a group of genetically determined pure lower motor neuron disorders. Nascent pre-mRNA transcripts are processed in the nucleus to produce mature mRNA by removal of introns. SMA with arthrogryposis and bone fractures is characterized by a pattern of weakness indistinguishable from SMA type 1, and congenital long-bone fractures. Distal muscle wasting in a scapuloperoneal distribution may be myopathic or neurogenic in origin. Patients frequently have mild androgen insensitivity, causing gynecomastia, testicular atrophy, oligospermia and erectile dysfunction. Clinical features of androgen insensitivity suggested a defect in androgen-reoeptor function.
Cellular reactions against Burkitt lymphoma cells. II. Effector cells obtained by allogeneic stimulation in mixed leukocyte cultures (1972)

Abstract A new colony inhibition test has been employed to detect effector cell activity of normal human leukocytes after stimulation with allogeneic cells. The responding cells in one‐way mixed leukocyte culture show strong activity in this assay, and effector cell activity is at least in part antigenically specific. Specificity of the CI activity was found to be dependent on the dose of effector cells added and the nature of the stimulator cell used. Stimulation with allogeneic leukocytes yielded a response which was strongly restricted in its CI activity to the appropriate target cell, while stimulation with Burkitt lymphoma‐derived cell lines resulted in CI activity which was cross‐reactive with other BL‐derived cell lines. These data indicate the presence of cross‐reactive antigens on two LCL lines derived from Burkitt lymphomas which can sensitize normal leukocytes to yield a cytotoxic response.
High-Performance Electric Drives for Aerospace More Electric Architectures Part I -- Electric Machines (2007)

This paper discusses the problem of obtaining electric machines (EM) for high performance electric drives (HPED) used in more electric architecture (MEA) applicable to aircraft, spacecraft, and military ground vehicles. The HPED are analyzed by those aspects of six sigma theory that relate to critical-to-quality (CTQ) subjects. Using this approach, weight, volume, reliability, efficiency, and cost CTQ are addressed to develop a balance among them, resulting in an optimized system. The influence of machine controllers and system considerations is discussed. As a part of the machine evaluation process, speeds, bearings, complexity, rotor mechanical and thermal limitations, torque pulsation, current, and power densities, are considered. A methodology for electric machine selection is demonstrated. An example of high-speed, high-performance machine application is shown. A system approach is used for overall electric machine selection and optimization. The presented material is a synopsis of the extensive engineering experience accumulated in Honeywell International.
TL-4 CRASH TESTING OF THE F411 BRIDGE RAIL (2004)

Texas Department of Transportation (TxDOT) and Florida Department of Transportation (FDOT) frequently receive requests to provide aesthetically pleasing traffic rails for use on select bridges and roadways. TxDOT, in response to providing context sensitive design alternatives, initiated a project to develop additional aesthetically pleasing rail alternatives. Under a previous TxDOT project, the F411 bridge rail was constructed and crash tested to Test Level 3 (TL-3). The TL-3 test is a 4405-lb (2000 kg) pickup impacting the railing at 25 deg and 62.2 mi/h (100 km/h). This test requires both containment and stability, and non-overturning. Since some breakage of the parapet is possible, potential for vehicle snagging is likely. Vehicle snagging can contribute to vehicle instabilities in the redirection sequence and potential rollover. The TxDOT F411 bridge rail contained and redirected the vehicle, which remained upright during and after the collision period. The bridge rail met the required specification for NCHRP Report 350 test 3-11. The objective of this research is the full-scale crash test and evaluation of the F411 to Test Level 4 (TL-4). The most direct approach for accomplishing the objectives of this task is to perform a full-scale TL-4 crash test of this railing design. The TL-4 vehicle is a single-unit box-van truck impacting the railing at 15 deg and 49.7 mi/h (80 km/h). While containment is required, overturning of the vehicle 90 deg is an acceptable test outcome. The TxDOT F411 bridge rail performed acceptably for NCHRP Report 350 test 4-12. Based on the performance of the F411 bridge rail in the full-scale crash test to TL-4 test conditions, the F411 may be used where containment of 18,000 lb single-unit trucks is desired.
On-line Rheometry: A Tool to Monitor Polymer Nanocomposites Production (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Sacha Trevelyan Mould, Simão Pedro Pereira, Joana Margarida Barbas, João Miguel Nóbrega, Ana Vera Machado, José António Covas; On‐line Rheometry: A Tool to Monitor Polymer Nanocomposites Production. AIP Conf. Proc. 15 July 2011; 1375 (1): 147–155. https://doi.org/10.1063/1.3604474 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search