gebhart/patrepeval huggingface dataset:
High-frequency cortical neural inputs to muscles during movement cancellation (2023)

Abstract Cortical beta (13-30 Hz) and gamma (30-60 Hz) oscillations have been investigated during motor processing. Although they are at frequencies greater than the dynamic bandwidth of muscle contraction, these oscillations are partly transmitted from the cortex to motoneurons and muscles. Little is known about when and why this transmission occurs. We developed an experimental approach to examine these high frequency inputs to motoneurons under different motor states while maintaining a stable force, thus constraining behaviour. We acquired brain and muscle activity during a ‘GO’/’NO-GO’ task. In this experiment, the effector muscle for the task (tibialis anterior) was kept tonically active during the trials, while participants (N=9) reacted to sequences of auditory stimuli by either keeping the contraction unaltered (‘NO-GO’ trials), or by quickly performing a ballistic contraction (‘GO’ trials). Motor unit (MU) firing activity was extracted from high-density surface and intramuscular electromyographic signals, and the changes in its spectral contents in the ‘NO-GO’ trials were analysed. We observed an increase in beta and low-gamma (30-45 Hz) activity post ‘NO-GO’ cue at the brain and muscle levels. There was also an increase in the activity within 8-12 Hz, which was only observed at the muscle level. Overall, our results suggest that the cortical processing of movement cancellation occurs at least in part via increased power of high-frequency oscillations transmitted downstream to the muscles. These changes occur without alterations in behaviour, suggesting that the downstream transmission of these high-frequency oscillations does not have a direct functional impact.
Multiphysics Modeling of BAW Filters (2015)

A novel approach for multiphysics modeling of BAW filters is presented allowing accurate and at the same time efficient modeling of BAW filters at high power levels. The approach takes the different types of losses and their spatial distribution into account in order to provide the required input for thermal simulation. The temperature distribution determined by thermal simulation is used to modify the geometry and the layer stack of each single resonator of the filter. In this way the required input for modeling of electromagnetic and acoustic behavior at high power level is generated. Moreover, the influence of the nonlinear behavior on the frequency shift of the resonance frequency is investigated. The high accuracy of the modeling approach is verified by measurements of the S-parameters and the temperature distribution by infrared thermography during high power loads.
Using glTF for streaming CityGML 3D city models (2016)

In this paper, we describe an approach for efficiently streaming large and highly detailed 3D city models, which is based on open standards and open source developments. This approach meets both the rendering performance requirements in WebGL enabled web browsers and the requirements by 3D Geographic Information Systems regarding data structuring, geo-referencing and accessibility of feature properties. 3D city models are assumed to be available as CityGML data sets due to its widespread adoption by public authorities. The Cesium.js open source virtual globe is used as a platform for embedding custom 3D assets. glTF and related formats are used for efficiently encoding 3D data and for enabling streaming of large 3D models. In order to fully exploit the capabilities of web browsers and standard internet protocols, a series of filtering and data processing steps must be performed, which are described in this paper.
Method and apparatus for capturing carbon dioxide during combustion of carbon containing fuel (2023)

A boiler system having a series of boilers. Each boiler includes a shell having an upstream end, a downstream end, and a hollow interior. The boilers also have an oxidizer inlet entering the hollow interior adjacent the upstream end of the shell and a fuel nozzle positioned adjacent the upstream end of the shell for introducing fuel into the hollow interior of the shell. Each boiler includes a flue duct connected to the shell adjacent the downstream end for transporting flue gas from the hollow interior. Oxygen is delivered to the oxidizer inlet of the first boiler in the series. Flue gas from the immediately preceding boiler in the series is delivered through the oxidizer inlet of each boiler subsequent to the first boiler in the series.
Orbital Ordering in β-Substituted Porphyrins:  Resonance Raman Spectra of the Radical Cations (1997)

Copper β-substituted 5,10,15,20-tetraphenylporphyrins (CuTPP-β) and their cation radicals with varied electron-withdrawing/donating substituents were studied by resonance Raman spectroscopy. A1g, Eu and substituent modes were observed with Soret excitation. Q-band spectra and CuTPP-d7-CHO shifts aided mode assignments. In the cations, a2u is indicated as the highest occupied molecular, although an a1u CuTPP-OCH3 HOMO is predicted. Examination of the absorption spectra reveals orbital switching may occur for the neutral but not for the cationic species.
Isolation and biochemical analysis of vesicles from taurohyodeoxycholic acid-infused isolated perfused rat livers (2013)

No significant changes in biliary lipids were observed in the fractions from THDC-infused livers; however, PDE activity was significantly increased compared to the control livers.
Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents (2015)

Emerging knowledge regarding B cells in organ transplantation has demonstrated that these cells can no longer be taken as mere generators of deleterious Abs but can also act as beneficial players. We previously demonstrated in a rat model of cardiac allograft tolerance induced by short-term immunosuppression an accumulation in the blood of B cells overexpressing inhibitory molecules, a phenotype also observed in the blood of patients that spontaneously develop graft tolerance. In this study, we demonstrated the presence in the spleen of regulatory B cells enriched in the CD24(int)CD38(+)CD27(+)IgD(-)IgM(+/low) subpopulation, which are able to transfer donor-specific tolerance via IL-10 and TGF-β1-dependent mechanisms and to suppress in vitro TNF-α secretion. Following anti-CD40 stimulation, IgD(-)IgM(+/low) B cells were blocked in their plasma cell differentiation pathway, maintained high expression of the inhibitory molecules CD23 and Bank1, and upregulated Granzyme B and Irf4, two molecules described as highly expressed by regulatory B cells. Interestingly, these B cells recognized specifically a dominant donor Ag, suggesting restricted specificity that could lead to a particular B cell response. Regulatory B cells were not required for induction of tolerance and appeared following Foxp3(+)CD4(+)CD25(+) regulatory T cells, suggesting cooperation with regulatory T cells for their expansion. Nevertheless, following transfer to new recipients, these B cells migrated to the allograft, kept their regulatory profile, and promoted local accumulation of Foxp3(+)CD4(+)CD25(+) regulatory T cells. Mechanisms of regulatory B cells and their cell therapy potential are important to decipher in experimental models to pave the way for future developments in the clinic.
A novel therapeutic strategy for skeletal disorders: Proof of concept of gene therapy for X-linked hypophosphatemia (2022)

Brief Summary: The authors developed a liver-targeting adeno-associated virus (AAV) vector carrying C-terminal FGF23 (cFGF23) to inhibit FGF23 signalling in a mouse model for X-linked hypophosphataemic rickets (hyp-duk mice). They were able to show that a single injection of AAV cFGF23 rescued the hyp-duk phenotype.
Le choix des porte-greffes de la vigne pour les sols calcaires (1972)

La chlorose ferrique de la Vigne était une maladie physiologique assez bénigne dans les vignobles plantés francs de pied avec des cépages de Vitis vinifera L. Après l'invasion phylloxérique de la fin du siècle dernier, l'emploi de porte-greffes issus d'espèces américaines (Vitis riparia, Vitis labrusca, etc...) fit apparaître de très graves symptômes de chlorose dans les sols calcaires. Ce n'est qu'après l'obtention de porte-greffes issus de croisements avec Vitis berlandieri (41 B, 333 EM, etc...) que la plantation dans les zones les plus chlorosantes (Charente, Champagne) put être réalisée avec succès. A ces premiers porte-greffes résistants à la chlorose vinrent successivement s'ajouter de nouvelles variétés provenant essentiellement des croisements : Vitis riparia x Vitis berlandieri et Vitis rupestris x Vitis berlandieri. Ce sont ces porte-greffes qui sont utilisés pour les plantations actuelles.
Evidence That Heat Shock Protein-70 Associated with Progesterone Receptors Is not Involved in Receptor-DNA Binding (1991)

In the absence of hormone, human progesterone receptors (PR) are recovered in the cytosolic fraction of cell lysates as a multimeric complex containing the steroid-binding polypeptide, heat shock protein-90 (hsp90), and heat shock protein-70 (hsp70). Activated forms of human PR that acquire the ability to bind to DNA are dissociated from hsp90, but retain association with hsp70. The present study has examined whether associated hsp70 has a function in receptor-DNA binding. When activated PR was bound to specific target DNA in a gel shift assay, no hsp70 was detectable in the PR-DNA complex, as evidenced by the failure of several antibodies to hsp70 to affect the mobility or the amount of complexes. To determine whether hsp70 might indirectly influence DNA-binding activity, we have examined the effect of hsp70 dissociation on PR-DNA-binding activity. Dissociation was achieved either by treatment of immunoaffinity-purified immobilized PR complexes with ATP or by the binding of PR complexes to ATP-agarose, followed by elution with high salt. Under both conditions, dissociation from hsp70 neither enhanced nor impaired the ability of PR to bind to specific DNA. These results suggest that hsp70 is not involved in PR binding to DNA, either directly by participating in DNA binding or indirectly by modulating PR-DNA-binding activity. This implies that hsp70 functions at an earlier stage in the receptor activation pathway. Consistent with the known involvement of hsp70 in stabilizing unfolded states of other target proteins, we propose that hsp70 may assist in nuclear transport of PR or in assembly-disassembly of the 8-10S multimeric complex.
Urinary Excretion Measurements after Accidental Inhalation of 99mTc and 99Mo (1994)

The urinary excretion rate of 90Mo and 99mTc following an accidental occupational exposure has been measured for 1.3-10 days post-exposure. Estimations of intakes and doses based on these results are presented.
COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : OVERVIEW OF THE STUDIES (2000)

The National Institute of Health Sciences and 28 member companies of the Japan Pharmaceutical Manufacturers Association (JPMA) have conducted a validation study intended to examine whether or not lesions in the male reproductive organs noted in 4-week treatment studies can also be detected after 2-week treatment. In this study, lesions in the male reproductive organs after 2-week treatment were, therefore, compared with those after 4-week treatment. A total of 24 test substances was evaluated, these being nucleic acid modulators, cell division inhibitors, central hormonal modulators, hormonal drugs and their antagonists, other drugs and general chemicals. Among these substances, theophylline did not cause any appreciable lesions in the male reproductive organs even after 4-week treatment in the preliminary studies. With busulfan, data reported in the literature was not reproduced in the preliminary study and all animals died. Therefore, detailed examinations were not conducted for busulfan and theophylline. The remaining 22 test substances, when given to animals for 2 weeks at doses equal to or higher than for 4-week treatment, caused lesions similar to those noted after 4 weeks. It is evident from these findings that effects of pharmaceuticals on the male reproductive organs can be detected in most cases with 2-week treatment.
Conducting Polymer Electrodes Printed on Hydrogel (2010)

We report herein the micropatterning of poly(3,4-ethylenedioxythiophene) (PEDOT) on a hydrogel, agarose, to provide a fully organic, moist, and flexible electrode. The PEDOT/agarose electrodes were prepared through two electrochemical processes: electropolymerization of PEDOT into the hydrogel and electrochemical-actuation-assisted peeling. We also present a typical application of the PEDOT/agarose electrode to the cultivation of contractile myotubes.
A 28 GHz HPT/HBT monolithically integrated photoreceiver for hybrid fibre radio distribution systems (2002)

High-speed, long-wavelength InP/InGaAs MMIC photoreceiver based on an HPT/HBT shared layer integration scheme has been designed, fabricated and characterised. The performance of individual devices and integrated circuit was investigated through detailed CAD-based analysis and characterisation. The bipolar heterojunction phototransistor (HPT), with the same HBT layer structure, exhibited a DC responsivity of 0.25 A/W and an optical gain cut-off frequency of 70 GHz at /spl lambda/=1550 nm. The fabricated two stage cascode narrow band amplifier with an HPT and three HBT's demonstrated a transimpedance gain of 50 dB/spl Omega/ and a -3 dB bandwidth of 4 GHz at the frequency of 28 GHz. A system evaluation of the MMIC photoreceiver was also realised using a subcarrier at 27.875 GHz modulated with a 25 Mb/s 16 QAM signal, and a BER of 10/sup -9/ for a C/N of 24.3 dB was achieved.
Analysis of polarization plane rotation characteristic in 2D photonic crystal waveguide with chiral medium by condensed node spatial network (2005)

Using the photonic band gap in photonic crystals, the fundamental waveguide structures for the light wavelength range have been developed. Based on the fine structure of these many functional devices have been proposed by analytical or numerical simulation methods and the experiments of trial manufacture. In this paper, the treatment of chiral dielectric in the Condensed Node Spatial Network for the vector potential is explained, and we show the polarization plane rotation property in air-hole and pillar type photonic crystal waveguide structures with the chiral medium substrate. Then, we show the fundamental advantage of the air-hole type photonic crystal waveguide structure in application to a mode converter. © 2005 Wiley Periodicals, Inc. Electr Eng Jpn, 152(1): 7–14, 2005; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/eej.20098
Influence of Dietary Fiber on Aortic Sudanophilia in Vervet Monkeys (1981)

Vervet monkeys were fed a cholesterol-free, semipurified diet containing 40% sucrose, 25% casein, 14% coconut oil and 15% fiber for 23 weeks. The fibers used were cellulose, wheat straw or alfalfa. Serum lipid and lipoprotein levels were highest in the monkeys fed the cellulose-containing diet. Liver lipids were slightly higher in the cellulose-fed monkeys. The ratio of endogenous to exogenous cholesterol was estimated using isotopically labeled sterol and sterol precursor and found to be similar in all three groups. The levels of endogenous or exogenous cholesterol in the serum and liver of alfalfa-fed monkeys were lower than the levels in the other two groups, which were similar. The ratio of exogenous to endogenous cholesterol in the feces was highest in the monkeys fed alfalfa. Monkeys fed alfalfa exhibited the lowest lithogenic index. Cholesterol 7α-hydroxylase activity was highest in livers of monkeys fed wheat straw. The data suggest that alfalfa inhibits absorption and reabsorption of cholesterol more than wheat straw or cellulose. Monkeys fed cellulose exhibited more severe aortic sudanophilia than those fed the other two fibers.
Fundamental insulation characteristics of high-pressure CO<sub>2</sub> gas for gas-insulated power equipment - effect of coating conductor on insulation performance and effect of decomposition products on creeping insulation of spacer - (2008)

Currently, environmental problems such as global warming are important issues, and SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> has been identified as a greenhouse gas with a long atmospheric lifetime. Therefore, in the long term, it is preferable to reduce the amount of SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> used as an insulating gas. It is thus important to discuss the possibility of using more environmentally friendly gases as alternative insulation for gas-insulated apparatus. In this paper, we describe the fundamental insulation breakdown characteristics of high-pressure CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gas at gas pressures of up to 1.0 MPa under simulated practical conditions, including the insulation breakdown characteristics of a high-voltage conductor with an insulating coating and the effect of decomposition products on the creeping insulation of a spacer. With the aim of enhancing insulation performance, we discuss the effect of the type of insulating coating on insulation performance. The breakdown electric field was increased by 20% by coating the conductor. It was verified that the application of an insulating coating is a practical method for enhancing the insulation performance of high-pressure CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gas. It was also verified that the decomposition products have only a slight effect on the creeping insulation of the spacer except for when there is heavy pollution on the insulating spacer. However, if a large amount of decomposition products is expected to be deposited on the insulating spacer during operation, which may cause a severe interruption to the current, it will be necessary to consider this factor in the insulation design.
ChemInform Abstract: Cyclopentene Synthesis from 1,3‐Dienes via Base‐Induced Ring Contraction of 3,6‐Dihydro‐2H‐thiopyrans: Studies on Diastereoselection and Mechanism. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Primal-Dual Parallel Approximation Technique Applied to Weighted Set and Vertex Cover (2002)

The paper describes a simple deterministic parallel/distributed (2+epsilon)-approximation algorithm for the minimum-weight vertex-cover problem and its dual (edge/element packing).
Low cost MCM-L fiber-optic transmitter package (2002)

A true implementation of MCM-L is accomplished by converting an existing fiber optic transmitter (FOTR) module fabricated by conventional technology in MCM-C, where high reliability has imposed hermeticity and established military standards and requirements. The MCM-L rendition provides a lower cost approach satisfying current budgets and high reliability without hermeticity. This MCM-L FOTR utilizes the latest laminate technological advances in order to achieve artwork routing parity of MCM-C, with comparable features to provide high density and miniaturization advanced microelectronic packaging that was not possible up until recently. Complete Chip on Board (COB) has been utilized to further advance miniaturization, also introducing flex input/output (I/O) leads integral to the MCM-L substrate. Extensive tests conducted after encapsulation providing excellent results both functionally and environmentally.
Nuclear magnetic resonance studies of pseudospin fluctuations in URu2Si2 (2013)

We report ${}^{29}$Si nuclear magnetic resonance measurements in single crystals and aligned powders of URu${}_{2}$Si${}_{2}$ in the hidden order and paramagnetic phases. The spin-lattice relaxation data reveal evidence of pseudospin fluctuations of U moments in the paramagnetic phase. We find evidence for partial suppression of the density of states below 30 K and analyze the data in terms of a two-component spin-fermion model. We propose that this behavior is a realization of a pseudogap between the hidden-order transition ${T}_{\mathrm{HO}}$ and 30 K. This behavior is then compared to other materials that demonstrate precursor fluctuations in a pseudogap regime above a ground state with long-range order.
Evaluation of Newer Risk Markers for Coronary Heart Disease Risk Classification (2012)

Optimizing coronary heart disease risk prediction can help target preventive interventions. This study examined whether the addition of newer markers (N-terminal fragment of prohormone B-type natri...
BMP9, but Not BMP10, Acts as a Quiescence Factor on Tumor Growth, Vessel Normalization and Metastasis in a Mouse Model of Breast Cancer (2021)

Background: Angiogenesis has become an attractive target for cancer therapy. However, despite the initial success of anti-VEGF (Vascular endothelial growth factor) therapies, the overall survival appears only modestly improved and resistance to therapy often develops. Other anti-angiogenic targets are thus urgently needed. The predominant expression of the type I BMP (bone morphogenetic protein) receptor ALK1 (activin receptorlike kinase 1) in endothelial cells makes it an attractive target, and phase I/II trials are currently being conducted. ALK1 binds with strong affinity to two ligands that belong to the TGF- family, BMP9 and BMP10. In the present work, we addressed their specific roles in tumor angiogenesis, cancer development and metastasis in a mammary cancer model. www.videleaf.com Conclusions: Altogether, our data show that in a tumor environment BMP9 and BMP10 play different roles and thus blocking their shared receptor ALK1 is maybe not appropriate. Indeed, BMP9, but not BMP10, acts as a quiescence factor on tumor growth, lung metastasis and vessel normalization. Our results also support that activating rather than blocking the BMP9 pathway could be a new strategy for tumor vessel normalization in order to treat breast cancer.
Electropolymerization of pyrrole‐2‐carboxylic acid and 4,4′‐dihydroxybenzophenone on platinum electrodes. Applications to assemble novel glucose sensors (1997)

Abstract The electropolymerization of pyrrole‐2‐carboxylic acid (PY‐2‐COOH) and of 4,4′‐dihydroxybenzophenone (DHB) has been carried out on Pt electrodes by scanning the potential from +0.4 V to + 1.4 V (vs. SCE) for PY‐2‐COOH and from 0.0 V to + 0.8 V (vs. SCE) for DHB, at scan rate of 2–5 mV/s, in phosphate buffer (PBS) pH 8. To test the permselectivity of these polymers, cyclic voltammograms of H 2 O 2 , ascorbic acid (AA), uric acid (UA) and acetaminophen (APAP) were carried out and results were compared with those obtained at the bare electrode. The electropolymerization in the presence of glucose oxidase was also carried out. The probes were then tested as glucose sensors. Glucose was detected, by amperometric measurements at +0.6 V (vs. SCE). The linear response to glucose was in the range 7 × 10 −6 ‐1.8 × 10 −3 mol/L, for the sensor prepared with PPY‐2‐COOH and 4 × 10 −6 −2 × 10 −3 mol/L, for the sensor prepared with PDHB. The detection limit was 5 × 10 −6 mol/L. for PPY‐2‐COOH and 2 × 10 −6 mol/L for PDHB. The response time of both polymers was 3–5 s. The stability of the electropolymerized films and the glucose probes was evaluated, in storage and operational conditions The glucose probes, stored in buffer at 4°C when not in use, showed a residual enzyme activity of 50%, after about two months.