gebhart/patrepeval huggingface dataset:
The effect of temperature and humidity on grooming behaviour of honeybee, Apis mellifera (Hym.: Apidae) colonies against varroa mite, Varroa destructor (Acari: Varroidae) (2009)

Grooming behaviour is one of the important mechanisms of honeybee defence against parasitic mites. In addition to genetical characteristics, environmental conditions affect the behavioural traits of honeybee colonies. The main objective of this study was to examine the effect of temperature and humidity on the ability of honeybee workers to remove varroa mites from their body. One hundred worker bees from resistant and susceptible colonies were placed in cages and infested with 40 varroa mites per cage. Cages from each group of workers were randomly assigned to a combination of temperature and humidity treatments. Individual cages were held in incubators at 10, 25 and 34ï°C under low (20%), medium (50%) and high (80%) humidity. The entire experiment was replicated three times (18 cages per replicate). The proportion of mites falling into the base of the cages (grooming), or migrating within the closed system and the number of dead bees were monitored on day 2, 4 and 6 of experiment. At the end of experiment the proportion of mites on the live bees, dead bees and in the equipment was also determined. The results showed significant differences in the ability of the two groups to groom mites off their bodies and that the relative effectiveness of the grooming in the two groups of bees was dependent upon the combination of temperature and humidity to which they were exposed. Total mite mortality of the two groups of bees was also different; however, it was not influenced by temperature. Total mite mortality may include grooming, or the natural mite fall that cannot relocate their host. In the programs that are attempting to breed bees with increased grooming behaviour and enhanced resistance to Varroa destructor (Anderson & Trueman), the environmental conditions should be considered under which experiments are carried out.
Comment on “Ideal strength and phonon instability in single-layerMoS2” (2014)

Li's paper [Phys. Rev. B 85, 235407 (2012)] presents density functional theory (DFT) results of stress as a function of different strain states. The work of Cooper et al. [Phys. Rev. B 87, 035423 (2013)] performs the same DFT calculations as part of an investigation into the nonlinear elastic properties of ${\mathrm{MoS}}_{2}$. Some of the DFT results of Li are substantially different from our recently published paper, Cooper et al. [Phys. Rev. B 87, 035423 (2013)]. Although both papers agree on states of equibiaxial stress, there is substantial disagreement on states of uniaxial tensile stress. In this Comment we show that our DFT computations are properly executed and consistent across three different DFT codes, including the one used by Li.
Determination of the Disulfide Array in Sapecin, an Antibacterial Peptide of Sarcophaga peregrina (Flesh Fly)1 (1990)

Journal Article Determination of the Disulfide Array in Sapecin, an Antibacterial Peptide of Sarcophaga peregrina (Flesh Fly) Get access Takashi Kuzuhara, Takashi Kuzuhara Faculty of Pharmaceutical Sciences, The University of TokyoBunkyo-ku, Tokyo 113 Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuki Nakajima, Yuki Nakajima Faculty of Pharmaceutical Sciences, The University of TokyoBunkyo-ku, Tokyo 113 Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenji Matsuyama, Kenji Matsuyama Faculty of Pharmaceutical Sciences, The University of TokyoBunkyo-ku, Tokyo 113 Search for other works by this author on: Oxford Academic PubMed Google Scholar Shunji Natori Shunji Natori 2 Faculty of Pharmaceutical Sciences, The University of TokyoBunkyo-ku, Tokyo 113 2To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 107, Issue 4, April 1990, Pages 514–518, https://doi.org/10.1093/oxfordjournals.jbchem.a123077 Published: 01 April 1990 Article history Received: 08 December 1989 Published: 01 April 1990
Response of bats to light with different spectra: light-shy and agile bat presence is affected by white and green, but not red light (2017)

Artificial light at night has shown a remarkable increase over the past decades. Effects are reported for many species groups, and include changes in presence, behaviour, physiology and life-history traits. Among these, bats are strongly affected, and how bat species react to light is likely to vary with light colour. Different spectra may therefore be applied to reduce negative impacts. We used a unique set-up of eight field sites to study the response of bats to three different experimental light spectra in an otherwise dark and undisturbed natural habitat. We measured activity of three bat species groups around transects with light posts emitting white, green and red light with an intensity commonly used to illuminate countryside roads. The results reveal a strong and spectrum-dependent response for the slow-flying <i>Myotis</i> and <i>Plecotus</i> and more agile <i>Pipistrellus</i> species, but not for <i>Nyctalus</i> and <i>Eptesicus</i> species. <i>Plecotus</i> and <i>Myotis</i> species avoided white and green light, but were equally abundant in red light and darkness. The agile, opportunistically feeding <i>Pipistrellus</i> species were significantly more abundant around white and green light, most likely because of accumulation of insects, but equally abundant in red illuminated transects compared to dark control. Forest-dwelling <i>Myotis</i> and <i>Plecotus</i> species and more synanthropic <i>Pipistrellus</i> species are thus least disturbed by red light. Hence, in order to limit the negative impact of light at night on bats, white and green light should be avoided in or close to natural habitat, but red lights may be used if illumination is needed.
Identification of Vibrio spp. (other than V. vulnificus) recovered on CPC agar from marine natural samples. (2000)

Two hundred and eighty four presumptive but not confirmed Vibrio vulnificus isolates grown on cellobiose-polymixin B-colistin agar (CPC) at 40 degrees C, recovered from sea water samples from Valencia, Spain, during a microbiological survey for V. vulnificus, were phenotypically identified. Most of the isolates (91%) corresponded to Vibrio species. V. harveyi (24%) and V. splendidus(19%) were the most abundant species identified, followed by V. navarrensis (13%), V. alginolyticus (8%) and V. parahaemolyticus (5%). The ability to grow on CPC agar and ferment cellobiose of several V. vulnificus strains from different origins and serovars, including reference strains, was tested. Most serovar E isolates and 25% of non-serovar E isolates could not grow on CPC agar.
Development of XML-based software and service commerce language XSCL and JavaBeans player (2002)

We propose the XML-based component commerce language XSCL (eXtensible Software specification and Commerce Language) and JavaBeans Component Player. ESD (Electronic Software Distribution) and ASP (Application Service Provider) are gaining ground in software distribution and provision. However, the representations of software/service specification and commerce information vary vendor by vendor. It is indispensable to provide a common representation of software/service specification and commerce in order to properly understand and compare software, services and software components. Furthermore, it is still difficult to specify the complex dynamic behavior and various non-functional aspects of software. Thus, it is helpful for the potential users of software to provide a tool to remotely exercise the software at his/her computer over the Internet. We developed the SCB (Software/Service Commerce Broker) on which we can provide a digital catalog of software with a HTML-based language SCL (Software specification and Commerce Language) and Component Player. Although it was effective in trial use, the representation capability is relatively weak due to the low-level representation capability of HTML. Thus, we developed the new language XSCL (eXtensible SCL) based on XML and accompanied JavaBeans Player.
SIP APIs for voice and video communications on the web (2011)

Existing standard protocols for the web and Internet telephony fail to deliver real-time interactive communication from within a web browser. In particular, the client-server web protocol over reliable TCP is not always suitable for end-to-end low latency media path needed for interactive voice and video communication. To solve this, we compare the available platform options using the existing technologies such as modifying the web programming language and protocol, using an existing web browser plugin, and a separate host resident application that the web browser can talk to. We argue that using a separate application as an adaptor is a promising short term as well as long-term strategy for voice and video communications on the web.
Supplementary Data from Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort (2023)

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IDT SciTools: a suite for analysis and design of nucleic acid oligomers (2008)

DNA and RNA oligomers are used in a myriad of diverse biological and biochemical experiments. These oligonucleotides are designed to have unique biophysical, chemical and hybridization properties. We have created an integrated set of bioinformatics tools that predict the properties of native and chemically modified nucleic acids and assist in their design. Researchers can select PCR primers, probes and antisense oligonucleotides, find the most suitable sequences for RNA interference, calculate stable secondary structures, and evaluate the potential for two sequences to interact. The latest, most accurate thermodynamic algorithms and models are implemented. This free software is available at http://www.idtdna.com/SciTools/SciTools.aspx.
Effects of osmoprotectant compounds on NCAM polysialylation under hyperosmotic stress and elevated pCO2 (2002)

Elevated osmolality and pCO(2) have been shown to alter sialylation in a protein-specific manner. In Chinese hamster ovary (CHO)MT2-l-8 cells, tPA sialylation changed only slightly from 40 to 250 mm Hg pCO(2), whereas neural cell adhesion molecule polysialic acid (NCAM PSA) content decreased by up to 70% at 250 mm Hg pCO(2), pH 7.2. NCAM PSA content also decreased with increasing NaCl or NH(4)Cl concentration. This suggests that PSA content is a sensitive indicator of conditions that may alter glycosylation. Amino acids and their derivatives have been used to protect hybridoma and CHO cell growth under hyperosmotic stress. We examined the impact of osmoprotectants on NCAM PSA content in CHO MT2-1-8 cells under hyperosmolality (up to 545 mOsm/kg) and at 195 and 250 mm Hg pCO(2). NCAM PSA content at 545 mOsm/kg was at least two-fold greater in the presence of glycine betaine or L-proline compared to that without osmoprotectant. Surprisingly, in the presence of 20 mM glycine betaine, PSA levels were 50-60% of the control level for osmolalities ranging from 320 to 545 mOsm/kg. Thus, glycine betaine inhibits NCAM polysialylation at osmolalities below 435 mOsm/kg and is beneficial at higher osmolalities. In contrast to glycine betaine, L-proline increased PSA content by 25-120% relative to the unprotected culture at < or =545 mOsm/kg. The decrease in NCAM PSA levels of CHO MT2-1-8 cells cultured at 195 mm Hg pCO(2)-435 mOsm/kg was not mitigated by the presence of 25 mM glycine betaine, glycine, or L-threonine, even though all of these compounds enhanced cell growth. At 250 mm Hg pCO(2), all osmoprotectants tested (20 mM L-threonine, L-proline, glycine, or glycine betaine) increased NCAM polysialylation, with 20 mM glycine betaine restoring NCAM PSA to near control levels. Thus, osmoprotectants may (partially) offset changes in glycosylation, as well as the inhibition of growth, in cells under environmental stress. Supernatant beta-galactosidase levels, which increase upon alkalization of acidic organelles, did not differ significantly under elevated pCO(2) and hyperosmolality from that at control conditions.
Assembling well-arranged covalent organic frameworks on MOF-derived graphitic carbon for remarkable formaldehyde sensing (2020)

Constructing heterostructures with advanced architectures is an effective strategy for enhancing the crystallinity and functional performance of covalent organic frameworks (COFs). Herein, a novel core-shell heterostructure integrating a metal-organic framework (MOF)-derived graphitic carbon core (GC) and a well-arranged COF shell, termed MOF-GC@COF, is reported. ZIF-67 dodecahedra are first chemically etched with a weak organic acid and further converted to MOF-GC via thermal pyrolysis. In the subsequent step, β-ketoenamine-linked COF nanofibers are vertically assembled on the surface of the MOF-GC cores to generate the MOF-GC@COF heterostructure. As a proof-of-concept application, the as-prepared MOF-GC@COF heterostructure is used as an effective quartz crystal microbalance (QCM) sensor for the adsorption of formaldehyde. Benefiting from the synergistic effect of the hybrid composition and the advantages of the core-shell heterostructure, the newly prepared MOF-GC@COF heterostructure exhibits excellent sensing performance toward formaldehyde with rapid adsorption kinetics, high sensitivity, and superior selectivity.
FOLFIRINOX (F-NOX) followed by individualized radiation for borderline-resectable pancreatic cancer (BRPC): Toxicity, R0 resection, and interim survival data from a prospective phase II study. (2017)

4113 Background: F-NOX is increasingly utilized in BRPC as neoadjuvant therapy. However, prospective data remains limited; the largest series is a 22 patient (pt) cooperative group trial (Alliance A021101), in which 14 pts had R0 resection. In this study, we evaluate neoadjuvant F-NOX followed by individualized chemoradiation (CRT) for BRPC. Methods: Pts ECOG PS 0-1 with biopsy-proven BRPC defined by NCCN criteria were enrolled in a single institution, NCI-sponsored phase II study (NCT01591733). Pts received F-NOX for 8 cycles. If after chemotherapy the tumor was radiographically resectable, pts received short course CRT in 5 (protons 25 GyE) or 10 fractions (photons 30 Gy) with capecitabine 825 mg/m2 bid. If the tumor was still abutting vasculature, pts received CRT to 50.4 Gy with a vascular boost to 58.8 Gy. Primary endpoint was R0 resection rate. Results: 50 pts were enrolled from 8/2012 to 8/2016. Two pts were ineligible (lung metastasis, negative biopsy); 48 pts were evaluable. Median age was 62y (46-74). Median tumor size was 37 mm (21-56). Thirty-six pts (75%) had pancreatic head tumors. Median follow up was 18.2 months among 31 patients still alive. Of the evaluable pts, 40 (83%) completed therapy. Reasons for not completing therapy include pt withdrawal (3), physician decision (3), unacceptable toxicity (1) and progression (1). Grade 3 or greater toxicity occurred in 48% of pts, but no individual grade 3 toxicity exceeded 15%. Twenty-seven pts (56%) had short course CRT, while 13 pts (27%) had long course CRT. Twenty-nine pts were resected; R0 resection was achieved in 28/29 (96.5%). R0 resection rate among all evaluable pts was 58.3%. Median PFS among all evaluable pts was was 14.7 months; mOS was 37.7 months, with 1y OS 79.5% and 2y OS 59.3%. Among resected patients, mOS has not been reached. 1y PFS was 78.1% and 2y PFS 55.4%; 1y OS was 92.6% and 2y OS was 80.6%. Conclusions: Preoperative F-NOX followed by individualized chemoradiation in BRPC results in high R0 resection rates as well as prolonged mPFS and mOS in this large prospective cohort. Clinical trial information: NCT01591733.
Effect of exportin 1/XPO1 nuclear export pathway inhibition on coronavirus replication (2023)

Nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication. Thus, inhibiting the XPO1-mediated nuclear export pathway with selective inhibitors has a diverse effect on virus replication by regulating antiviral, proviral, and anti-inflammatory pathways. The XPO1 inhibitor, Selinexor, is an FDA-approved anticancer drug predicted to have antiviral or proviral functions against viruses. Here, we observed that pretreatment of cultured cell lines from human or mouse origin with nuclear export inhibitor Selinexor significantly enhanced protein expression and replication of Mouse Hepatitis Virus (MHV), a mouse coronavirus. Knockdown of cellular XPO1 protein expression also significantly enhanced the replication of MHV in human cells. However, for SARS-CoV-2, selinexor treatment had diverse effects on virus replication in different cell lines. These results indicate that XPO1-mediated nuclear export pathway inhibition might affect coronavirus replication depending on cell types and virus origin.
Improvement in Reliability and Energy Yield Prediction of Thin-Film CdS/CdTe PV Modules (2006)

In this work, we illustrate improvement in thin-film PV module durability via process optimization. Data are presented from large installations, allowing accurate estimation of failure rates and distributions of failure modes. Improvement in product quality is also described; we show that recent thin-film products can meet industry expectations for consistent power output. In addition, results of product characterization performed at First Solar are presented. Dependence of module output on irradiance and temperature is illustrated, and we show that common assumptions about such dependence (based on experience with conventional PV technology) may not hold for thin-film modules. Predicted behavior of module output (as computed with PV system modeling software) and real-world data are compared. It is shown that adjustment of the parametric description of the module can be used to successfully reduce discrepancy between predicted and actual module behaviors
A Method for Measuring Online Audiences (2013)

We present a method for measuring the reach and frequency of online ad campaigns by audience attributes. This method uses a combination of data sources, including ad server logs, publisher provided user data (PPD), census data, and a representative online panel. It adjusts for known problems with cookie data and potential non-representative and inaccurate PPD. It generalizes for multiple publishers and for targeting based on the PPD. The method includes the conversion of adjusted cookie counts to unique audience counts. The benefit of our method is that we get both reduced variance from server logs and reduced bias from the panel. Simulation results and a case study are presented. 1
The Effect of Sterculia Bulk on the Viscosity of Stomal Output from Twelve Patients with Ileostomy (1978)

The addition of 15g of sterculia bulk (Inolaxol) to the daily food patients with ileostomy increased the viscosity of the stomal output by roughly 100%. The clinical result of this change was beneficial in 9 out of 12 patients in terms of diminished bandaging difficulties. Adding bulk to the diet of patients with ileostomy may thus facilitate the management of the stoma by increasing the viscosity of the output.
Novel human and mouse genes encoding a shank‐interacting protein and its upregulation in gastric fundus of W/WV mouse (2003)

Gene analysis showed that SIPL1 differentially express in the gastric fundus of normal and W/WV mice. The upregulation of SIPL1 in the fundus of W/WV mice, and expression in the upper gastrointestinal tract suggest that the SIPL1 gene could be associated with ICC function in mice and humans.
Impregnation Process for Preparation of Palladium Catalyst (1982)

担持触媒の活性成分の担持分布を制御することを目的として, 塩化パラジウム溶液によるアルミナ担体の含浸実験を行った。担持分布は初期含浸液pH, 初期Pd濃度, 液固比, 含浸液温度などの因子により決定されることが明らかとなった。またその効果をプロセス工学的に検討し, これらの因子を積極的に操作することによって所要の濃度分布を有する触媒を再現性よく製造することができた。さらに担持機構を吸着よりもむしろ「担体細孔内に生じたpH分布に依存する被担持成分の溶解度の差異に基づく沈殿」と考えるべきであることを示し, その妥当性を実験的に検証することができた。
Local recurrences in patients with breast cancer at the North Carolina memorial hospital (1970–1982) (1986)

A study of predictive factors for locoregional recurrences after curative surgery for breast cancer was undertaken. Specifically, the authors wished to determine whether such recurrences correlated with either hormonal receptor status or a delay between the initial biopsy and the definitive surgery. A retrospective chart review was done on all women with breast cancer who had surgery for cure between 1970 and 1982. Factors analyzed included, among others, size of the tumor, clinical and pathologic status of the axilla, estrogen and progesterone receptors status, and delay between biopsy and definitive surgery. There were 404 patients studied. Pathologic axillary nodal status was the most important predictor of locoregional recurrence, with failures in 36 of 188 (19%) node-positive but only 9 of 216 (4%) node-negative patients (P = 0.0001). In node-positive patients, tumor size was a predictor of local recurrence, with failure in only 4 of 51 (8%) of tumors less than 2 cm, but in 14 of 44 (32%) of tumors greater than 6 cm (P = 0.004). Progesterone receptor (PR) status correlated with locoregional recurrence, but estrogen receptor status did not. In node-positive women, there were 4 of 14 PR-negative but 0 of 15 PR-positive local failures (P = 0.017); this result has not been previously reported. The presence of palpable axillary disease was also found to be a predictor of local recurrence. Finally, no increase in locoregional recurrence could be attributed to the delay between biopsy and definitive surgery. Two new predictors for locoregional recurrence in breast cancer, not previously emphasized, are PR and clinical axillary status. Should these findings be substantiated, patients at high risk for locoregional recurrence could then be more readily identified.
Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients. (1993)

Paclitaxel is metabolized, and putative metabolic products can be found in plasma of patients treated with the drug. Our results indicate that myelosuppression can be predicted by the measurement of the duration of plasma concentrations above the threshold of 0.1 mumol/L.
Emerging applications, services and engineering for [Guest Editorial] (2015)

The rapid advancements in wireless communications are expected to increase the demand for radio spectrum resources by orders of magnitude during the next decade. This problem must be addressed using technology and regulatory innovations for significant improvements in spectrum utilization in cellular networks. Emerging cognitive radio technology has been identified as a high-impact disruptive innovation that could provide solutions to the cellular traffic congestion problems and exploit the underutilized spectral resources to pave an application-driven path toward the next generation of cellular technology.
Verminderte Interferon-alpha Produktion plasmacytoider dendritischer Zellen bei Patienten mit akuter HBV und HCV Infektion (2004)

Hintergrund: Die plasmacytoiden dendritischen Zellen (pDC) sind neben ihrer Fähigkeit zur Antigenpräsentation die wesentlichen Interferon-alpha (IFN-α) Produzenten des Menschen. Da die HCV als auch die HBV Infektion erfolgreich mit IFN-α behandelt werden kann, ist die Beeinträchtigung der endogenen IFN-α Produktion als viraler Persistenzmechanismus vorstellbar.
A Simple Route to N-ω-Chloroalkylisatins from Cyclic t-Anilines, Oxalyl Chloride and DABCO (2002)

para-Substituted N-phenylpyrrolidines, -piperidines, -perhydroazepines and -morpholines react with oxalyl chloride and DABCO to give the pharmaceutically useful intermediates, N-ω-haloalkylisatins, under mild conditions and generally good yields.