gebhart/patrepeval huggingface dataset:
Nature and consequences of non-covalent interactions between flavonoids and macronutrients in foods (2013)

Many of the potential health benefits of flavonoids have been associated with their specific chemical and biological properties including their ability to interact and bind non-covalently to macronutrients in foods. While flavonoid-protein interactions and binding have been the subject of intensive study, significantly less is understood about non-covalent interactions with carbohydrates and lipids. These interactions with macronutrients are likely to impact both the flavonoid properties in foods, such as their radical scavenging activity, and the food or beverage matrix itself, including their taste, texture and other sensorial properties. Overall, non-covalent binding of flavonoids with macronutrients is primarily driven by van der Waals interactions. From the flavonoid perspective, these interactions are modulated by characteristics such as degree of polymerization, molecular flexibility, number of external hydroxyl groups, or number of terminal galloyl groups. From the macronutrient standpoint, electrostatic and ionic interactions are generally predominant with carbohydrates, while hydrophobic interactions are generally predominant with lipids and mainly limited to interactions with flavonols. All of these interactions are involved in flavonoid-protein interactions. While primarily associated with undesirable characteristics in foods and beverages, such as astringency, negative impact on macronutrient digestibility and hazing, more recent efforts have attempted to leverage these interactions to develop controlled delivery systems or strategies to enhance flavonoids bioavailability. This paper aims at reviewing the fundamental bases for non-covalent interactions, their occurrence in food and beverage systems and their impact on the physico-chemical, organoleptic and some nutritional properties of food.
High-velocity oxy-fuel thermally sprayed CoNiCrAlY coatings on Ti-6Al-4V alloy: High cycle fatigue properties of coating (2007)

Mechanical response of HVOF-coated workpieces is important for the life assessment of coating adherence, particularly for the coated surfaces being exposed to high-temperature environments prior to mechanical tests. In the present study, fatigue tests are carried out for Ti-6Al-4V workpieces coated via HVOF spraying of AMDRY 995 (CoNiCrAlY) powders. In order to simulate the effect of high temperature on the fatigue response of coating, workpieces were heat treated at the annealing temperature of the alloy for 1 h. Surface morphology prior to and after fatigue testing is carried out using scanning electron microscopy (SEM) and optical microscopy, while energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD) are carried out for metallurgical examinations. It is found that heat treatment results in early fatigue failure of the workpieces owing to thermally induced stresses developed at the coating-substrate interface. The metallurgical changes in the substrate material, and formation of brittle oxygen compounds and alumina particles left over from grit blasting at the coating-substrate material interface are responsible for the coating failure.
Investigating the practicality of hazardous material detection using Unmanned Aerial Systems (2014)

Recently, Unmanned Aerial Systems (UASs) have been implemented by the Melbourne Fire Brigade (MFB) in Australia. UASs are being utilised as a means to improve situational awareness in fire fighting operations. The goal of this work is to investigate if these systems can have their role extended to include hazardous material detection and monitoring. The practicality of sensing gases with a UAS needs to be assessed, given that any aerodynamic effect or system will influence the environment it is operating in, changing airflow and mixing. This is very important for rotor wing aircraft, and the UAS that is being operated by the MFB is the Cyberquad, a quad rotor aircraft. In this work we conducted a controlled field experiment in a quasi-controlled environment, in which a Volatile Organic Compound (VOC) was released. The concentration was then measured at various locations with conventional handheld VOC sensors, one of which was attached to the UAS. The height of the sensors was varied, and measurements were taken with the rotors on and off. Preliminary results suggest that the UAS can be used to monitor hazardous materials, and when the rotors are on, the efficiency of the measurement may be improved, with the UAV located very close to ground level.
Differential diagnosis of parkinsonism. (1995)

The diagnosis of idiopathic Parkinson's disease (PD) is essentially clinical and is reached by exclusion. An akinetic rigid syndrome frequently means PD, although a number of other neurodegenerative diseases can share bradykinesia, rigidity, postural instability, and sometimes tremor. Parkinsonism can be classified as follows: degenerative, metabolic, vascular, iatrogenic, toxic, infectious, traumatic, and secondary to mass effect. The diagnostic approach are discussed.
Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. (1989)

In response to IgE and specific multivalent antigen, mast cell lines (both growth factor-dependent and -independent) induce the transcription and/or secretion of a number of cytokines having a wide spectrum of activities. We have identified IL-1, IL-3, IL-5, IL-6, IFN-gamma, GM-CSF, JE, MIP1 alpha, MIP1 beta, and TCA3 RNA in at least two of four mast cell clones. The production of these products (except JE) is activation-associated and can be induced by IgE plus antigen. In selected instances cytokine expression can also be induced by activation with Con A or phorbol ester plus ionophore, albeit to levels less than those observed with IgE plus antigen. In addition, long-term mast cell clones and primary cultures of bone marrow-derived mast cells specifically release IL-1, IL-4, and/or IL-6 bioactivity after activation. These findings suggest that in addition to their inflammatory effector function mast cells may serve as a source of growth and regulatory factors. The relationship of mast cells to cells of the T lymphocyte lineage is discussed.
A note on Norton's theorem for queuing networks (1983)

We propose a simple proof of Norton's theorem for multiclass quasireversible networks.
Shall we trust WDDL? (2009)

Security is not only a matter of cryptographic algorithms robustness but becomes also a question of securing their implementation. P. Kocher’s differential power analysis (DPA) is one of the many side-channel attacks that are more and more studied by the security community. Indeed, side-channel attacks (SCA) have proved to be very powerful on cryptographic algorithms such as DES and AES, customarily implemented in a wide variety of devices, ranging from smart-cards or ASICs to FPGAs. Among the proposed countermeasures, the “dual-rail with precharge logic” (DPL) aims at hiding information leaked by the circuit by making the power consumption independent of the calculation. However DPL logic could be subject to second order attacks exploiting timing difference between dual nets. In this article, we characterize by simulation, the vulnerability due to timing unbalance in the eight DES substitution boxes implemented in DPL WDDL style. The characterization results in a classification of the nodes according to their timing unbalance. Our results show that the timing unbalance is a major weakness of the WDDL logic, and that it could be used to retrieve the key using a DPA attack. This vulnerability has been experimentally observed on a full DES implementation using WDDL style for Altera Stratix EP1S25 FPGA.
ChemInform Abstract: THE ACCELERATED CORROSION OF COPPER‐NICKEL ALLOYS IN SULFIDE‐POLLUTED SEAWATER: MECHANISM NO. 2 (1983)

Abstract Die gemeinsame Gegenwart von Sulfid und Sauerstoff in Meerwasser verursacht wesentlich höhere Korrosionsgeschwindigkeiten als dies bei alternierender Einwirkung von Sulfid und Sauerstoff auf eine 90 Cu‐ 10 Ni‐Legierung der Fall ist.
PIPENETa wireless sensor network for pipeline monitoring (2007)

US water utilities are faced with mounting operational and maintenance costs as a result of aging pipeline infrastructures. Leaks and ruptures in water supply pipelines and blockages and overflow events in sewer collectors cost millions of dollars a year, and monitoring and repairing this underground infrastructure presents a severe challenge. In this paper, we discuss how wireless sensor networks (WSNs) can increase the spatial and temporal resolution of operational data from pipeline infrastructures and thus address the challenge of near real-time monitoring and eventually control. We focus on the use of WSNs for monitoring large diameter bulk-water transmission pipelines. We outline a system, PipeNet, we have been developing for collecting hydraulic and acoustic/vibration data at high sampling rates as well as algorithms for analyzing this data to detect and locate leaks. Challenges include sampling at high data rates, maintaining aggressive duty cycles, and ensuring tightly time-synchronized data collection, all under a strict power budget. We have carried out an extensive field trial with Boston Water and Sewer Commission in order to evaluate some of the critical components of PipeNet. Along with the results of this preliminary trial, we describe the results of extensive laboratory experiments which are used to evaluate our analysis and data processing solutions. Our prototype deployment has led to the development of a reusable, field-reprogrammable software infrastructure for distributed high-rate signal processing in wireless sensor networks, which we also describe.
A novel formulation for the study of the ascending aortic fluid dynamics with in vivo data (2022)

Numerical simulations to evaluate thoracic aortic hemodynamics include a computational fluid dynamic (CFD) approach or fluid-structure interaction (FSI) approach. While CFD neglects the arterial deformation along the cardiac cycle by applying a rigid wall simplification, on the other side the FSI simulation requires a lot of assumptions for the material properties definition and high computational costs. The aim of this study is to investigate the feasibility of a new strategy, based on Radial Basis Functions (RBF) mesh morphing technique and transient simulations, able to introduce the patient-specific changes in aortic geometry during the cardiac cycle. Starting from medical images, aorta models at different phases of cardiac cycle were reconstructed and a transient shape deformation was obtained by proper activating incremental RBF solutions during the simulation process. The results, in terms of main hemodynamic parameters, were compared with two performed CFD simulations for the aortic model at minimum and maximum volume. Our implemented strategy copes the actual arterial variation during cardiac cycle with high accuracy, capturing the impact of geometrical variations on fluid dynamics, overcoming the complexity of a standard FSI approach.
Anti-mitochondrial type M5 and anti-cardiolipin antibodies in autoimmune disorders: studies on their association and cross-reactivity. (1987)

In a series of 42 positive sera, anti-mitochondrial type M5 antibodies (AMA-M5) were found most frequently in patients with SLE (24) and SLE-like syndromes. Patients with AMA-M5 displayed a higher prevalence of thrombocytopenia, thrombosis, biological false positive seroreactions for syphilis, lupus-like anticoagulant activity and anti-cardiolipin antibodies in comparison with a group of 43 SLE AMA-M5 negative patients. The strong association between anti-phospholipid and AMA-M5 antibodies cannot be explained entirely by cross-reactivity between these two groups of antibodies, as indicated by absorption experiments and studies using affinity purified antibody preparations. However, cardiolipin liposomes were able to reduce partially the titres of AMA-M5 sera, suggesting that a small population of AMA-M5 antibodies exists that cross-reacts with cardiolipin. The existence of this population was further substantiated by our demonstration that an IgM monoclonal antibody, from a patient with Waldenström's macroglobulinaemia, displayed both anti-cardiolipin and AMA-M5 activity, and AMA-M5 activity was completely inhibited by cardiolipin.
Pyridyl-urea Derivatives as Blockers of Aβ-induced mPTP Opening for Alzheimer's Disease (2012)

Department of Biochemistry and Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, KoreaReceived August 8, 2012, Accepted August 27, 2012Key Words : mPTP, Cyclophilin D, Alzheimer’s disease, Pyridyl-urea, ATP productionAlzheimer’s disease is a progressive neurodegenerativedisorder in aged people and the pathogen is known asamyloid beta (A β) with different slicing.
Perspectives and results on the stability and stabilizability of hybrid systems (2000)

This paper introduces the concept of a hybrid system and some of the challenges associated with the stability of such systems, including the issues of guaranteeing stability of switched stable systems and finding conditions for the existence of switched controllers for stabilizing switched unstable systems. In this endeavour, this paper surveys the major results in the (Lyapunov) stability of finite-dimensional hybrid systems and then discusses the stronger, more specialized results of switched linear (stable and unstable) systems. A section detailing how some of the results can be formulated as linear matrix inequalities is given. Stability analyses on the regulation of the angle of attack of an aircraft and on the PI control of a vehicle with an automatic transmission are given. Other examples are included to illustrate various results in this paper.
Zero-crossing detector based reconfigurable analog system (2010)

A reconfigurable analog system is presented that implements pipelined ADCs, switched-capacitor filters, and programmable gain amplifiers. Each block employs a zero-crossing based circuit for easy reconfigurability and power efficiency. Configured as a 10-bit ADC, the chip consumes 1.92mW at 50MSPS with ENOB of 8.02b and FOM of 150fJ/conversion-step. A third order Butterworth filter is also demonstrated. The chip is implemented in 65nm technology.
Wireless Clinical Alerts and Patient Outcomes in the Surgical Intensive Care Unit (2002)

Errors in medicine have gained public interest since the Institute of Medicine published its 1999 report on this subject. Although errors of commission are frequently cited, errors of omission can be equally serious. A computerized surgical intensive care unit (SICU) information system when coupled to an event-driven alerting engine has the potential to reduce errors of omission for critical intensive care unit events. Automated alerts and patient outcomes were prospectively collected for all patients admitted to a tertiary-care SICU for a 2-year period. During the study period 3,973 patients were admitted to the SICU and received 13,608 days of care. A total of 15,066 alert pages were sent including alerts for physiologic condition (6,163), laboratory data (4,951), blood gas (3,774), drug allergy (130), and toxic drug levels (48). Admission Simplified Acute Physiology Score and Acute Physiology and Chronic Health Evaluation II score, SICU lengths of stay, and overall mortality rates were significantly higher in patients who triggered the alerting system. Patients triggering the alert paging system were 49.4 times more likely to die in the SICU compared with patients who did not generate an alert. Even after transfer to floor care the patients who triggered the alerting system were 5.7 times more likely to die in the hospital. An alert page identifies patients who will stay in the SICU longer and have a significantly higher chance of death compared with patients who do not trigger the alerting system.
How does angiotensin AT2 receptor activation help neuronal differentiation and improve neuronal pathological situations? (2012)

The angiotensin type 2 (AT(2)) receptor of angiotensin II has long been thought to be limited to few tissues, with the primary effect of counteracting the angiotensin type 1 (AT(1)) receptor. Functional studies in neuronal cells have demonstrated AT(2) receptor capability to modulate neuronal excitability, neurite elongation, and neuronal migration, suggesting that it may be an important regulator of brain functions. The observation that the AT(2) receptor was expressed in brain areas implicated in learning and memory led to the hypothesis that it may also be implicated in cognitive functions. However, linking signaling pathways to physiological effects has always proven challenging since information relative to its physiological functions has mainly emerged from indirect observations, either from the blockade of the AT(1) receptor or through the use of transgenic animals. From a mechanistic standpoint, the main intracellular pathways linked to AT(2) receptor stimulation include modulation of phosphorylation by activation of kinases and phosphatases or the production of nitric oxide and cGMP, some of which are associated with the Gi-coupling protein. The receptor can also interact with other receptors, either G protein-coupled such as bradykinin, or growth factor receptors such as nerve growth factor or platelet-derived growth factor receptors. More recently, new advances have also led to identification of various partner proteins, thus providing new insights into this receptor's mechanism of action. This review summarizes the recent advances regarding the signaling pathways induced by the AT(2) receptor in neuronal cells, and discussed the potential therapeutic relevance of central actions of this enigmatic receptor. In particular, we highlight the possibility that selective AT(2) receptor activation by non-peptide and selective agonists could represent new pharmacological tools that may help to improve impaired cognitive performance in Alzheimer's disease and other neurological cognitive disorders.
Combining Multipath Routing and Congestion Control for Robustness (2006)

Flexible routing schemes mitigate some of the problems associated with uncertain traffic patterns and workloads by making the exact location of capacity less important: if there is available capacity the routing scheme will find it. In this paper we propose a combined multipath routing and congestion control architecture that can provide performance improvements to the end user and simplifies network dimensioning for operators. We describe a flow-level model, able to handle streaming and file transfer traffic, with stochastic arrivals, and look at a fluid limit. We describe a congestion controller and path selection algorithm that automatically balances traffic across the lowest cost paths, and we suggest ways in which just two paths may be used, with a random selection policy. A notable feature of a multipath congestion controller is that it cannot be tuned to a single RTT, hence it differs from standard TCP with respect to RTT bias. We show that under certain conditions the allocation of flows to paths is optimal and independent of the flow control algorithm used. Scalability of the architecture results from implementing the algorithms at end-systems. We illustrate by examples how such an approach can halve response times and double the load that a network can carry.
Red Hat Enterprise Linux Administration Unleashed (2007)

This comprehensive guide can help you administer Red Hat Enterprise Linux 5 effectively in any production environment, no matter how complex or challenging.Long-time Red Hat insider Tammy Fox brings together today's best practices for the entire system lifecycle, from planning and deployment through maintenance and troubleshooting. Fox shows how to maximize your efficiency and effectiveness by automating day-to-day maintenance through scripting, deploying security updates via Red Hat Network, implementing central identity management services, and providing shared data with NFS and Samba.Red Hat Enterprise Linux 5 Administration Unleashed contains extensive coverage of network and web services, from the Apache HTTP server and Sendmail email services to remote login with OpenSSH. Fox also describes Red Hat's most valuable tools for monitoring and optimization and presents thorough coverage of security-including a detailed introduction to Security-Enhanced Linux (SELinux). Streamline deployment with Kickstart Find, install, update, remove, and verify software Detect, analyze, and manage hardware Manage storage with LVM, RAID, ACLs, and quotas Use Red Hat Enterprise Linux 5 on 64-bit and multi-core systems Administer users and groups more efficiently and securely Ensure trustworthy backup and rapid recovery Script and schedule tasks to run automatically Provide unified identity management services Configure Apache, BIND, Samba, and Sendmail Monitor and tune the kernel and individual applications Protect against intruders with SELinux and ExecShield Set up firewalls with iptables Enable the Linux Auditing System Use virtualization to run multiple operating systems concurrently Chapter 4 Understanding Linux Conceptsi¾ Chapter 15 Creating a Web Server with the Apache HTTP Server i¾ Chapter 19 Explaining Other Common Network Services Chapter 20 Monitoring System Resources i¾ Chapter 22 Monitoring and Tuning Applications i¾ Chapter 23 Protecting Against Intruders with Security-Enhanced Linux i¾ Chapter 25 Linux Auditing System Appendix A Installing Proprietary Kernel Modulesi¾ Appendix B Creating Virtual Machines i¾ Tammy Fox served as technical leader of Red Hat's documentation group, where she wrote and revised The Red Hat Enterprise Linux System Administration Guide. She was founding editor of Red Hat Magazine, now an online publication reaching more than 800,000 system administrators and others interested in Linux and open source. She wrote Red Hat's LogViewer tool and has written and contributed to several Red Hat configuration tools. Fox is also the founding leader of the Fedora Docs Project.Register your book at www.samspublishing.com/register for convenient access to updates and to download example scripts presented in this book.Category:i¾ Linux/NetworkingCovers:i¾ Red Hat Enterprise Linux 5User Level:i¾ Intermediatei¾Advanced
k-Anonymization Revisited (2008)

In this paper we introduce new notions of k-type anonymizations. Those notions achieve similar privacy goals as those aimed by Sweenie and Samarati when proposing the concept of k-anonymization: an adversary who knows the public data of an individual cannot link that individual to less than k records in the anonymized table. Every anonymized table that satisfies k-anonymity complies also with the anonymity constraints dictated by the new notions, but the converse is not necessarily true. Thus, those new notions allow generalized tables that may offer higher utility than k-anonymized tables, while still preserving the required privacy constraints. We discuss and compare the new anonymization concepts, which we call (1, k )-, (k, k)- and global (1, k)-anonymizations, according to several utility measures. We propose a collection of agglomerative algorithms for the problem of finding such anonymizations with high utility, and demonstrate the usefulness of our definitions and our algorithms through extensive experimental evaluation on real and synthetic datasets.