gebhart/patrepeval huggingface dataset:
<i>Ex vivo</i> venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia (2022)

The BCL-2 inhibitor venetoclax has revolutionized the treatment of acute myeloid leukemia (AML) in patients not benefiting from intensive chemotherapy. Nevertheless, treatment failure remains a challenge, and predictive markers are needed, particularly for relapsed or refractory AML. Ex vivo drug sensitivity testing may correlate with outcomes, but its prospective predictive value remains unexplored. Here we report the results of the first stage of the prospective phase II VenEx trial evaluating the utility and predictiveness of venetoclax sensitivity testing using different cell culture conditions and cell viability assays in patients receiving venetoclax-azacitidine. Participants with de novo AML ineligible for intensive chemotherapy, relapsed or refractory AML, or secondary AML were included. The primary endpoint was the treatment response in participants showing ex vivo sensitivity and the key secondary endpoints were the correlation of sensitivity with responses and survival. Venetoclax sensitivity testing was successful in 38/39 participants. Experimental conditions significantly influenced the predictive accuracy. Blast-specific venetoclax sensitivity measured in conditioned medium most accurately correlated with treatment outcomes; 88% of sensitive participants achieved a treatment response. The median survival was significantly longer for participants who were ex vivo-sensitive to venetoclax (14.6 months for venetoclax-sensitive patients vs. 3.5 for venetoclax-insensitive patients, P<0.001). This analysis illustrates the feasibility of integrating drug-response profiling into clinical practice and demonstrates excellent predictivity. This trial is registered with ClinicalTrials.gov identifier: NCT04267081.
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord (1990)

Using in vivo microdialysis in the dorsal spinal cord of the rat, we have previously observed increases in glutamate and aspartate during exposure to a noxious stimulus. The present investigation was designed to determine whether these increases may be mediated by substance P. Infusion of 1 mM of substance P in the dialysis fluid increased the concentrations of glutamate and aspartate, similar to the response seen during noxious stimulation. In addition, substance P also increased the concentrations of the inhibitory amino acids glycine and taurine. Calcitonin gene-related peptide, previously shown to enhance substance P-induced biting and scratching behavior, produced no effect on amino acid release by itself but potentiated the apparent release of taurine by substance P. To assess the importance of substance P-induced amino acid release in sensory processing, we examined the influence of taurine and of excitatory amino acid antagonists on the biting and scratching behavior produced by excitatory amino acids and substance P. Taurine selectively inhibited only substance P-induced biting and scratching while excitatory amino acid antagonists inhibited only excitatory amino acid-induced behavior. To further explore the ability of taurine to inhibit the substance P-induced behavior, 3 tests of nociception were then used. Pretreatment with taurine inhibited the nociceptive-related writhing behavior produced by an intraperitoneal injection of acetic acid in mice but failed to alter the latency of response in the hot plate or tail flick assay.(ABSTRACT TRUNCATED AT 250 WORDS)
Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors (2020)

Thirteen carneic acids were isolated from the fungal endophyte <i>Phomopsis</i> sp. SNB-LAP1-7-32. Their structures were identified by mass spectrometry and extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Compounds <b>1</b>-<b>13</b> were investigated for their antipolymerase activities against DENV polymerase and Zika NS5. Five of them exhibited significant inhibition of dengue polymerase with IC<sub>50</sub> values in the 10 to 20 μM range without cytotoxicity. None inhibited Zika virus NS5 protein.
Medium access control (MAC) (2011)

<P>This chapter contains sections titled: <UL> <LI> <P>MAC functionality</P> </LI> <LI> <P>MAC frame exchange protocol</P> </LI> <LI> <P>Basic access mechanism</P> </LI> <LI> <P>Centrally controlled access mechanism (i.e., PCF)</P> </LI> <LI> <P>Frame formats</P> </LI> <LI> <P>General frame format</P> </LI> <LI> <P>Control frame subtypes</P> </LI> <LI> <P>Data frame subtypes</P> </LI> <LI> <P>Management frame subtypes</P> </LI> <LI> <P>Components of the management frame body</P> </LI> <LI> <P>Other MAC operations</P> </LI> </UL> </P>
The Impact of Testicular Torsion on Testicular Function (2019)

Torsion of the spermatic cord is a urological emergency that must be treated with acute surgery. Possible long-term effects of torsion on testicular function are controversial. This review aims to address the impact of testicular torsion (TT) on the endocrine- and exocrine-function of the testis, including possible negative effects of torsion on the function of the contralateral testis. Testis tissue survival after TT is dependent on the degree and duration of TT. TT has been demonstrated to cause long-term decrease in sperm motility and reduce overall sperm counts. Reduced semen quality might be caused by ischemic damage and reperfusion injury. In contrast, most studies find endocrine parameters to be unaffected after torsion, although few report minor alterations in levels of gonadotropins and testosterone. Contralateral damage after unilateral TT has been suggested by histological abnormalities in the contralateral testis after orchiectomy of the torsed testis. The evidence is, however, limited as most human studies are small case-series. Theories as to what causes contralateral damage mainly derive from animal studies making it difficult to interpret the results in a human context. Large long-term follow-up studies are needed to clearly uncover changes in testicular function after TT and to determine the clinical impact of such changes.
Characterization of MR spectroscopic imaging of the human head and limb at 2.0 T. (1988)

Using section-select and phase-encoding gradients, the authors obtained phosphorus chemical shift images of the human head and limb. Phosphorus spectra were acquired from planar sections divided into voxels as small as 7 cm3 in calf muscle and 27 cm3 in brain, with total examination times, including setup and proton locator imaging, of roughly 1 hour. Both spin-echo and free induction decay (FID) methods were employed; the FID gave superior results. Signal-to-noise ratios for the beta-adenosine triphosphate and phosphocreatine resonances were as high as 10:1 and 13:1 from volumes of 27 cm3 in brain.
Screening of Carbohydrate‐Specific Phage Antibodies Against Recombinant Human Erythropoietin (rHuEPO) using a Phage Display Antibody Library: Preliminary Study (2006)

This paper is a preliminary report on development of a screening method for carbohydrate-specific phage antibodies against recombinant human erythropoietin (rHuEPO), using a phage display antibody library. rHuEPO was oxidized with sodium periodate or treated with 1,4-dithiothreitol and guanidine hydrochloride for detecting the specificity of obtained phage antibodies. Of 100 phage clones, three initially showed higher carbohydrate-related specificity. One of them (No. 62) bound specifically to the carbohydrate chains of rHuEPO, while the other two (Nos. 63 and 83) might recognize the steric conformation related to both the carbohydrate and the polypeptide chain of rHuEPO. These phage antibodies may serve as useful capture ligands for future development of efficient analytical methods for rHuEPO.
The Production of a Root Surface Smear Layer by Instrumentation and its Removal by Citric Acid (1984)

The purpose of this study was to characterize, using the scanning electron microscope, the nature of root surfaces denuded by (1) root planing alone or (2) root planing plus citric acid treatment. Six teeth were extracted from three squirrel monkeys, and the coronal half of the root surface was planed to remove attached periodontal ligament fibers and cementum. Citric acid, pH 1, was topically applied to the denuded surfaces of 3 teeth. The surface of only root-planed specimens had an irregular surface which corresponded to a smear layer. Root surfaces that had received acid treatment after root planing exhibited funnel-shaped orifices of dentinal tubules, and intertubular zones with a fibrillar, mat-like morphology. The implications of the different root-surface characteristics are discussed.
Aging with Creativity (2018)

Renewed interest in creativity and novel thinking has recently been acknowledged to understand challenges of an increasingly complex world. Much of the interest has ignored the important aspects of aging with creativity. Brain pathways for divergent thinking are established well into old age. Neuroscience and imaging technologies show two separate, higher order, creative pathways from the hippocampus of memory and from the amygdala in the limbic system. The Temporal-Occipital-Parietal (TOP) cortical juncture manages the thoughts and memories rationally or with emotion. Pathways require fluidity, openness, and flexibility to engage in novel, uninhibited, thinking. Artistic and scientific creative thinking are similar but different. Basic knowledge of the domain, acquired by experience, is essential for divergent thoughts and creative products.
Surface dynamics and mechanics in liquid crystal polymer coatings (2015)

Based on liquid crystal networks we developed ‘smart’ coatings with responsive surface topographies. Either by prepatterning or by the formation of self-organized structures they can be switched on and off in a pre-designed manner. Here we provide an overview of our methods to generate coatings that form surface structures upon the actuation by light. The coating oscillates between a flat surface and a surface with pre-designed 3D micro-patterns by modulating a light source. With recent developments in solid state lighting, light is an attractive trigger medium as it can be integrated in a device for local control or can be used remotely for flood or localized exposure. The basic principle of formation of surface topographies is based on the change of molecular organization in ordered liquid crystal polymer networks. The change in order leads to anisotropic dimensional changes with contraction along the director and expansion to the two perpendicular directions and an increase in volume by the formation of free volume. These two effects work in concert to provide local expansion and contraction in the coating steered by the local direction of molecular orientation. The surface deformation, expressed as the height difference between the activated regions and the non-activated regions divided by the initial film thickness, is of the order of 20%. Switching occurs immediately when the light is switched ‘on’ and ‘off’ and takes several tens of seconds.
Comparative Study of Hematopoietic Differentiation between Human Embryonic Stem Cell Lines (2011)

Directed differentiation of human embryonic stem cells (hESCs) into any desired cell type has been hailed as a therapeutic promise to cure many human diseases. However, substantial roadblocks still exist for in vitro differentiation of hESCs into distinct cell types, including T lymphocytes. Here we examined the hematopoietic differentiation potential of six different hESC lines. We compare their ability to develop into CD34(+) or CD34(+)CD45(+) hematopoietic precursor populations under several differentiation conditions. Comparison of lymphoid potential of hESC derived- and fetal tissue derived-hematopoietic precursors was also made. We found diverse hematopoietic potential between hESC lines depending on the culture or passage conditions. In contrast to fetal-derived hematopoietic precursors, none of the CD34(+) precursors differentiated from hESCs were able to develop further into T cells. These data underscore the difficulties in the current strategy of hESC forward differentiation and highlight distinct differences between CD34(+) hematopoietic precursors generated in vitro versus in vivo.
Influence of Surface Wettability on Pool Boiling Heat Transfer (2009)

Although boiling process has been a major subject of research for several decades, its physics still remain unclear and require further investigation. This study aims at highlighting the effects of the surface wettability on pool boiling heat transfer. Nanocoating techniques were used to vary the water contact angle from 20 to 110° by modifying nanoscale surface topography and chemistry. The experimental results obtained disagree with the predictions of the classical models. A new approach of nucleation mechanism is established to clarify the nexus between the surface wettability and the nucleate boiling heat transfer. In this approach, we introduce the concept of macro- and micro-contact angles to explain the observed phenomenon.
Rational synthesis of F-doped iron oxides on Al2O3(0001) single crystals (2014)

F-doped α- and γ-Fe<sub>2</sub>O<sub>3</sub>nanostructures are grown on Al<sub>2</sub>O<sub>3</sub>(0001) by PE-CVD tailoring fluorine content, nano-organization and optical properties as a function of processing conditions.
Trigeminal Neuralgia Radiosurgery (2004)

Although medical therapy is of benefit to many patients with trigeminal neuralgia, surgical management is often performed for patients with medically refractory pain. Gamma knife radiosurgery has been advocated as a minimally invasive alternative surgical approach to microvascular decompression or percutaneous surgeries. In this article, we review the safety and efficacy of this technique and discuss potential ways to improve on results.
Indomethacin Decreases Arachidonic Acid Uptake in HCA-7 Human Colon Cancer Cells (2008)

Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal cancer. However, evidence is accumulating that NSAIDs have anti-cancer effects in addition to inhibiting cyclooxygenase (COX)-mediated prostanoid biosynthesis. We now show that indomethacin, a popular NSAID, significantly reduced the [3H]-arachidonic acid uptake in HCA-7 human colon cancer cells. Interestingly, no decrease in the uptake of [3H]-arachidonic acid occurred when the cells were treated with aspirin, diclofenac, and sulindac even though the concentrations of these NSAIDs were high enough to inhibit COX-2 activity. These findings suggest that indomethacin has a novel anti-cancer effect that may be independent of COX-2 inhibition.
Safety and efficacy of tofogliflozin in Japanese patients with type 2 diabetes mellitus in real‐world clinical practice: Results of 3‐month interim analysis of a long‐term post‐marketing surveillance study (J‐STEP/LT) (2019)

Our interim 12-month data suggest that tofogliflozin could be used safely and effectively in Japanese patients with type 2 diabetes mellitus, as tofogliflozin was well tolerated with low hypoglycemia risk, and significantly improved HbA1c and bodyweight.
The Interactive Bracelet: An Input device for Bimanual Interaction (2010)

The size of a mobile device limits its input capabilities. To address this problem, we propose the Interactive Bracelet, an input device worn on the wrist that brings bimanual gestures to the mobile or ubiquitous computer. We describe example scenarios that illustrate how we imagine the device could be used, and we discuss how the device can be implemented and what sensors and actuators should be included.
Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma (2023)

&lt;p&gt;HBV DNA levels in tumorous and non-tumorous tissues of individual patients with HBV-associated HCC.&lt;/p&gt;
Breath volatile metabolome reveals the impact of dietary fibres on the gut microbiota: Proof of concept in healthy volunteers (2022)

FiberTAG project was initiated from a European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL) and was supported by the Service Public de Wallonie (SPW-EER, convention 1610365, Belgium).
Adolescent survivors of burn injuries and their parents’ perceptions of recovery outcomes (2012)

Analysis of the BOQ completed by adolescents and their parents reveal similar estimates of recovery following the burn injury. These results suggest that the adolescent's reported outcomes can be used interchangeably with the parent's assessments, with the exception of appearance, itch, and school reentry, where there are some differences.
Does organizational learning capacity impact on organizational effectiveness? Research analysis of the metal industry (2009)

Purpose The aim of the study is to emphasize the importance of organizational learning capacity (OLC) and to measure its influence on organizational effectiveness (OE) in metalworking manufacturing. Design/methodology/approach The research plan has been stated as; looking for the survey questions in the literature, reaching the participants, informing them about the survey, gathering the data, and measuring and analyzing the data. The survey instrument has been applied on metal industry employees in Turkey. The valid responses have reached to 578. We analyzed the data by SPSS (Statistical Package for the Social Sciences) version 11.5. Findings There are significant correlations (at the 0.000 level) between OE and all OLC dimensions (systems orientation, organizational climate for learning orientation, knowledge acquisition and utilization orientation, and information sharing and dissemination orientation). The total explained variance of OE (depending on OLC) has been calculated as 65 percent. Research limitations/implications We have calculated the OE value in terms of employee satisfaction, customer orientation and financial and growth performance, whereas there may be other factors to be considered for the related value. Practical implications The organizations should consider knowledge‐intensive activities more precisely when constructing their strategic maps. Originality/value This study helps to fulfill the gap between the OE and OLC from a managerial point of view in metalworking manufacturing. The main audiences are global businesses as well as academic researchers.
Two-Phase Antithrombotic Protection After Anti-Glycoprotein VI Treatment in Mice (2006)

Anti-GPVI treatment induces 2-phase antithrombotic protection in mice consisting of a partial and transient inhibition of thrombin responses in platelets and a prolonged and complete loss of the collagen response.
Flexoelectricity-enhanced photovoltaic effect in trapezoid-shaped NaNbO3 nanotube array composites (2023)

In this work, we successfully prepared vertically aligned NaNbO3 nanotube (NN-NT) with trapezoidal shapes, in which the orthorhombic and monoclinic phases coexisted. According to the structure analysis, the NN-NT/epoxy composite film had excellent flexoelectric properties due to the lattice distortion caused by defects and irregular shape. The flexoelectric effect is the greatest in the vertical direction in the flexible NN-NT/epoxy composite film, and the flexoelectric coefficient ( $$\mu _{12}^\prime $$ ) is 2.77 × 10−8C·m−1, which is approximately 5-fold higher than that of the pure epoxy film. The photovoltaic current of the NN-NT/epoxy composite film increased from 39.9 to 71.8 nA·cm−2 in the direction of spontaneous polarization when the sample was bent upward due to the flexoelectricity-enhanced photovoltaic (FPV) effect. The flexoelectric effect of the NN-NT/epoxy composite film could modulate the photovoltaic response by increasing it by 80% or reducing it to 65% of the original value. This work provides a new idea for further exploration in efficient and lossless ferroelectric memory devices.
Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations. (1999)

Using different molecular techniques, DNA has been detected in the plasma of cancer patients with various types of tumors. We undertook the present study to investigate the presence of plasma DNA, before mastectomy, in patients with breast cancer at diagnosis and to analyze the clinicopathological spectrum of this subgroup of patients with respect to patients without DNA with tumor characteristics. We studied 62 patients with breast cancer, who were selected sequentially after mastectomy and diagnosis of breast carcinomas. Genomic DNA extracted from tumor and normal tissues, normal blood cells, and plasma was used for molecular studies. Alterations in polymorphic markers selected because they had been found to show a high rate of alterations in breast cancer in previous studies (D17S855, D17S654, D16S421, TH2, D10S197, and D9S161), as well as mutations in the p53 gene and aberrant methylation at the first exon of p16INK4a, were used to identify and characterize tumor and plasma DNA. Thirteen clinicopathological parameters were analyzed in each patient. We identified 56 cases (90%) with at least one molecular event in tumor DNA, and 41 cases (66%) with a similar alteration in plasma DNA. Comparison of the clinicopathological parameters between patients with and without plasma DNA revealed significant differences in the axillary involvement, rate of invasive ductal carcinoma, high proliferative index, and the parameter comprised of lymph node metastases, histological grade II, and peritumoral vessel involvement. A high proportion of breast cancer patients exhibited plasma DNA at diagnosis similar to tumor DNA, and its presence correlated significantly with pathological parameters associated with a poor prognosis.
Dietary supplementation with Clostridium butyricum modulates serum lipid metabolism, meat quality, and the amino acid and fatty acid composition of Peking ducks (2018)

The aim of this study was to investigate the effects of Clostridium butyricum (C. butyricum) on the performance, serum lipid metabolism, muscle morphology, meat quality, and fatty acid profiles of Peking ducks. A total of 1,500 Peking ducks were randomly divided into five groups with five replicates and were fed a non-antibiotic basal diet (Control) or a basal diet supplemented with either 200, 400, or 600 mg/kg of C. butyricum (2.0 × 109 CFU/g) or 150 mg of aureomycin/kg for 42 d. Compared with the control group, supplementation with C. butyricum increased the average daily weight gain but reduced the feed/gain ratio from 1 to 42 d of age. Similarly, dietary C. butyricum increased the activities of antioxidant enzymes but decreased the malondialdehyde (MDA) and lipid metabolites concentration. C. butyricum supplementation increased the muscle pH value at 45 min postmortem, the redness of the meat, and the contents of inosine acid (IMP) and intramuscular fat (IMF) in Peking ducks. By contrast, C. butyricum supplementation lowered the lightness, drip loss, and the shear force of breast meat. Supplementation with C. butyricum increased the concentrations of essential amino acids and flavor amino acids, as well as arachidonic acid (AA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and total polyunsaturated fatty acids (PUFA) in breast muscle. Dietary C. butyricum could positively improve performance, lipid metabolism, meat quality, and the amino acid and fatty acid composition in a dose-dependent manner. Therefore, C. butyricum is proposed as a feasible alternative feed additive for the production of healthier Peking duck meat with favorable properties.