gebhart/patrepeval huggingface dataset:
Lipophilic bis(monoaza crown ether) derivatives: synthesis and cation-complexing properties (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLipophilic bis(monoaza crown ether) derivatives: synthesis and cation-complexing propertiesHidefumi Sakamoto, Keiichi Kimura, Yasuaki Koseki, Mitsunori Matsuo, and Toshiyuki ShonoCite this: J. Org. Chem. 1986, 51, 25, 4974–4979Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/jo00375a041https://doi.org/10.1021/jo00375a041research-articleACS PublicationsRequest reuse permissionsArticle Views902Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of a Multiplex PCR Assay for Characterization of Embryonic Stem Cells (2013)

Several molecular methods like real-time PCR (Q-PCR), expression sequence tag (EST) scan, microarray and microRNA analysis, and massively parallel signature sequencing (MPSS) have proved to be increasingly sensitive and efficient for monitoring human embryonic stem cell (hESC) differentiation. However, most of these high-throughput tests have a limited use due to high cost, extended turnaround time, and the involvement of highly specialized technical expertise. Hence, there is a need of rapid, cost-effective, robust, yet sensitive method for routine screening of hESCs. A critical requirement in hESC cultures is to maintain a uniform undifferentiated state and to determine their differentiation capacity by showing the expression of germ-layer-specific gene markers. To determine the modulation of gene expression in hESCs during propagation, expansion, and differentiation via embryoid body (EB) formation, we developed a simple, rapid, inexpensive, and definitive multimarker, semiquantitative multiplex RT-PCR (mxPCR) platform technology. Among the 15 gene primers tested, 4 were pluripotent markers comprising of set 1; and 3 lineage-specific markers from each ecto-, meso-, and endoderm layers were combined as sets 2, 3, and 4, respectively. In summary, this study was performed to characterize hESCs on a molecular level and to determine the quality and degree of variability among hESC and their early progenies (EB). This single-reaction mxPCR assay was flexible and, by selecting appropriate reporter genes, can be designed for characterization of different hESC lines during routine maintenance and directed differentiation.
BCG Osteomyelitis as a Rare Cause of Mediastinal Tumor in a One-Year-Old Child (1992)

A one-year-old child with BCG osteomyelitis of the upper spine is reported. The child was admitted because of viral infections of the upper respiratory tract. A lateral x-ray examination of the lung showed what was thought to be a mediastinal tumor. The preoperative diagnostic problems are discussed, because the etiology in our case was unknown until the histological report arrived. The knowledge of the complication, of osteomyelitis after vaccination, is small although the first case was published more than 40 years ago. Since then about 300 cases have been reported in the literature. The disease is seen in the first five years of life in otherwise healthy children. Most cases are localized near the epiphysis of the long bones. A localization in the spine, as described in our case, has been published only three times before. The highest frequency of BCG osteomyelitis is reported in Finland and Sweden with about 40 cases per 1 million vaccinations.
Eavesdropping of quantum communication from a noninertial frame (2007)

We introduce a relativistic version of the quantum encryption protocol by considering two inertial observers who wish to securely transmit quantum information encoded in a free scalar quantum field state forming Minkowski particles. In a nonrelativistic setting a certain amount of shared classical resources is necessary to perfectly encrypt the state. We show that in the case of a uniformly accelerated eavesdropper the communicating parties need to share (asymptotically in the limit of infinite acceleration) just half of the classical resources.
Assessment of applicability of carreau, ellis, and cross models to the viscosity data of resin solutions (1993)

Abstract In this study, three popular rheological models, which fit adequately well to viscosity data of polymeric materials, are chosen for making a comparative assessment of their applicability to practical data. The resulting nonlinear equations of the three models are solved by using Levenberg Marquardt's algorithm. The assessment of their applicability to practical viscosity data of 66 solutions of two resins in 11 solvent systems and reported data of other polymers has been analyzed. The Carreau and Ellis models have yielded unique global estimates for various rheological parameters, whereas the Cross model yielded local solutions. However, both Carreau and Cross models yielded parameter estimates with low overall residual error. The three models are found to have good applicability to viscosity data of resin solutions in good and moderate solvents; however, some deviation is observed when they are tested for solvents in which the resin has poor solubility. © 1993 John Wiley &amp; Sons, Inc.
Guide méthodologique et technique pour la mise en œuvre de l’indice diatomique de Nouvelle-Calédonie (IDNC) (2022)

[Departement_IRSTEA]Eaux [TR1_IRSTEA]BELCA [ADD1_IRSTEA]Systèmes aquatiques soumis à des pressions multiples
Molecular hydrogels of therapeutic agents (2009)

This tutorial review aims to introduce a new kind of biomaterials-molecular hydrogels of therapeutic agents. Based on the molecular self-assembly in water, it is possible to transform therapeutic agents into analogues that form hydrogels without compromising their pharmacological efficacy. This transformation can be beneficial in three aspects: (i) the therapeutic agents become "self-deliverable" in the form of hydrogels; (ii) the self-assembly of hydrogelators of drugs might confer new and useful properties such as multivalency or high local densities; (iii) the exploration of molecular hydrogels of drugs may ultimately lead to bioactive molecules that have dual or multiple roles. By summarizing the reports on the molecular hydrogels made from clinical used drugs or other bioactive molecules, this article presents representative molecular hydrogels of therapeutics and outlines the promises and challenges for developing this new class of biomaterials.
Apoptosis and Cytotoxic T Lymphocytes (1993)

Apoptosis is a mode of cell death that occurs under normal physiological conditions. In vivo, it is most often found during normal tissue turnover, embryogenesis, metamorphosis, and endocrine-dependent tissue atrophy (Kerr et al., 1972; Wyllie et al., 1980). The inference has been made that cell death in these instances is “programmed,” meaning that it is a normal function of the cell, tissue, or organ. This has led some investigators to use the terms apoptosis and programmed cell death (PCD) interchangeably, although it is becoming apparent that there are examples of PCD which are not apoptotic and examples of apoptosis which are not truly programmed (Cohen, 1991; Cohen et al., 1992). Nevertheless, the fact that the morphological and biochemical changes associated with apoptosis are highly conserved in various cell types and systems suggests that an apoptotic mechanism (cell death program) exists in all cells that can be activated under the appropriate physiological conditions.
Heavy recycle solvent studies in two-stage coal liquefaction. Final technical report, September 1, 1982-December 30, 1983 (1984)

The objective of this program has been to study the chemistry of the components with high boiling points in a direct coal liquefaction recycle solvent and to identify those components which lead to higher overall yields and improved product stability in the initial coal dissolution step of direct coal liquefaction processes. The major conclusions are: -454 C recycle solvent is primarily aromatic hydrocarbons (73%) and contains almost no asphaltenes; +454 C recycle solvent is primarily asphaltenes and aromatic hydrocarbons; recycle solvent also contains aliphatic hydrocarbons, N-containing aromatics and O-containing aromatics; heteroatoms in coal derived materials seem to be grouped by type, i.e. acidic O and basic N and sulfur occur together; under helium a small net amount of hydrogen and more CO and CO/sub 2/ are produced than under hydrogen; under hydrogen the amounts of H/sub 2/S and hydrocarbon gases are increased and a small amount of hydrogen gas is usually consumed; overall coal conversions to THF solubles are improved by adding more -454 C solvent but decreased by adding +454 C solvent; for added fractions of -454 C solvent the pecent conversion to THF solubles increases in the order aromatic hydrocarbons (+7.2) > aliphatic hydrocarbons (+0.8) > no added solvent (0.0) > N-containing aromatics (-0.9) > O-containing aromatics (-22.1); percent conversion to THF solubles using -454 C solvent with +454 C solvent fractions added decrease in the order aliphatics (+3.7) > aromatic hydrocarbons (+3.0) > no added solvent (0.0) > O-containing aromatics (-9.3) > N-containing aromatics (-13.3); of the +454 C solvent components, aromatic hydrocarbons and aliphatic hydrocarbons are beneficial but total only approx. 25% of the +454 C recycle solvent; and steric effects may be important in determining the effectiveness of the heavier solvent components as liquefaction solvents. 28 references, 25 figures, 31 tables.
Estimating Field Properties of Soft Soil Using Penetration-Type S-Wave Probe (2009)

A new s-wave probe, called "MudFork", has been recently developed and is used in accurate measurements of shear wave velocities of soft soils. The probe is composed of two bender elements mounted on a "fork" having two blades, one element perturbing ground and the other one monitoring seismic waves, and can be penetrated using SPT(standard penetration test) rods pushed with a routine boring machine. To expand its use to estimate undrained shear strength and density, an attempt to correlate shear wave velocity to those properties was made at normally consolidated silt near Incheon, Korea. A simple linear relationship between shear strength and shear wave velocity was obtained, and a tentative relationship between density and shear wave velocity was also defined.
What is most important in predicting survival? Quantifying the relative effect of patient factors, stage, hospital, quality metrics, and treatment on survival following GI cancer resection. (2020)

e19203 Background: Prior studies have identified patient characteristics, TNM stage, quality metrics, and systemic therapy as factors associated with survival. However, studies have not quantified the relative predictive impact these factors have on survival. The purpose of this study was to rank the importance of factors effecting survival following GI cancer resection. Methods: The National Cancer Database identified patients who underwent potentially curative surgery for esophageal, gastric, pancreatic, colon, or rectal cancer from 2006-2015. Hierarchical Cox proportional hazards models for the outcome of 5-year overall survival assessed the proportion of explained variance by sociodemographic patient factors, TNM stage, the hospital where surgery was performed, perioperative quality metrics (lymph node [LN] yield, margin status, prolonged length of stay [LOS], unplanned readmission), and treatment (chemotherapy and radiotherapy [RT]). Results: Among 306,164 GI cancer resections, stage, LN yield, margin status, prolonged LOS, readmission, and chemotherapy were independently associated with survival. The relative importance of these factors varied by organ system. However, aside from patient factors, the hospital where surgery was performed ranked as one of the most important factors across all organ systems, and prolonged LOS was important across all organ systems. Conclusions: The hospital where surgery is performed is one of the most important factors explaining variation in survival, and it appears that prolonged LOS, which serves as a proxy for postoperative complications, also has a strong predictive ability on survival. Research identifying differences between hospitals that explain this hospital effect as well as which complications reduce survival is warranted. [Table: see text]
Ectopic expression of tropomyosin promotes myofibrillogenesis in mutant axolotl hearts (1998)

Expression of tropomyosin protein, an essential component of the thin filament, has been found to be drastically reduced in cardiac mutant hearts of the Mexican axolotl (Ambystoma mexicanum) with no formation of sarcomeric myofibrils.Therefore, this naturally occurring cardiac mutation is an appropriate model to examine the effects of delivering tropomyosin protein or tropomyosin cDNA into the deficient tissue.In this study, we describe the replacement of tropomyosin by using a cationic liposome transfection technique applied to whole hearts in vitro.When mouse ␣-tropomyosin cDNA under the control of a cardiac-specific ␣-myosin heavy chain promoter was transfected into the mutant hearts, tropomyosin expression was enhanced resulting in the formation of well-organized sarcomeric myofibrils.Transfection of a ␤-tropomyosin construct under control of the same promoter did not result in enhanced organization of the myofibrils.Transfection of a ␤-galactosidase reporter gene did not result in the formation of organized myofibrils or increased tropomyosin expression.These results demonstrate the importance of ␣-tropomyosin to the phenotype of this mutation and to normal myofibril formation.Moreover, we have shown that a crucial contractile protein can be ectopically expressed in cardiac muscle that is deficient in this protein, with the resulting formation of organized sarcomeres.
A cool modality to restore sinus rhythm (2020)

Abstract Background Slowing electrical conduction by cooling the myocardium can be used for defibrillation. We previously demonstrated the efficacy of a small cold device placed in oblique sinus (OS) in terminating atrial fibrillation (AF). However, the parameters needed to achieve effective atrial defibrillation are unknown. Purpose Assess effect of the size of cooled myocardium on frequency of AF termination in acute canine animal models. Methods Sternotomy was performed under general anesthesia in 10 acute canine experiments. AF was induced using rapid atrial pacing and intra-myocardial epinephrine and acetylcholine injections. Once AF sustained for at least 30s, either a cool (7–9°C) or placebo (body temperature) device was placed in the OS. Four device sizes were tested; ½X½, ¾X¾, and 1X1 inch devices and two ¾X¾ inch devices placed side by side simultaneously. Time to AF termination was recorded. Chi-squared or Fisher's exact test were used to compare the frequency of arrhythmia termination with cooling versus placebo. Results A total of 166 applications were performed (89 cool vs 77 placebo) in 10 animal experiments. Overall, AF terminated in 82% of the cooling applications vs. 67.5% of placebo (P=0.03, Figure 1). For the ½X½ inch device 88% of cold applications restored sinus rhythm vs. 63.6% for placebo (P=0.05). The frequency of sinus restoration for cold ¾X¾, 1X1 and two ¾X¾ side by side devices was 86.7%, 83.3% and 70% respectively. Time to sinus restoration when achieved was within three minutes was also not significantly changed. Conclusion Placing a cool device in the oblique sinus can terminate AF and efficacy is not affected by the size of device. Funding Acknowledgement Type of funding source: Private grant(s) and/or Sponsorship. Main funding source(s): MediCool Technologies
Phase 1 Cultural Resources Inventory of Public Access Lands in the Atchafalaya Basin, Vicinity of the Sherburne Wildlife Management Area, Pointe Coupee, St. Martin and Iberville Parishes, Louisiana (1994)

The first stage of a cultural resources inventory of Corps-owned lands in the Atchafalaya Basin Floodway included survey within two parcels (North and South Farms) with a total of 2400 acres. Auger tests to 2 and 4 meters failed to recover artifacts or sites. A plan for archeological investigations was developed for a much larger area, bounded by U.S. Hwy 190, the East Atchafalaya Basin Protection Levee, Interstate-10, and the Atchafalaya River. A review of previous investigations in the Atchafalaya Basin and of geomorphology indicates that sites predating the Coles Creek Period are unlikely. Historical research indicates that most activity occurred between about 1850 to 1880. After that, harvesting of timber occurred on a large-scale, commercial basis. Because of extreme rates of deposition within the larger area, this report recommends that archeological investigations be undertaken only in very restricted areas. Sherburne wildlife, Prehistory, Archaic, Poverty point, Tchefuncte, Baytown, Troyville, Coles creek, Plaquemine, Mississippi period, Atchafalaya.
Approaches to Prolong the Use of Uncuffed Hemodialysis Catheters: Results of a Randomized Trial (2011)

Gentamicin/heparin and taurolidine/citrate, used for locking UC, were similarly effective at preventing CRB and catheter thrombosis for up to 3 months, until a functional permanent vascular access became available. Both antimicrobial lock solutions were superior to heparin in CRB prevention with similar thrombosis rates.
Biomimetic and mechanically supportive 3D printed scaffolds for cartilage and osteochondral tissue engineering using photopolymers and digital light processing (2021)

Successful 3D scaffold designs for musculoskeletal tissue engineering necessitate full consideration of the form and function of the tissues of interest. When designing structures for engineering cartilage and osteochondral tissues, one must reconcile the need to develop a mechanically robust system that maintains the health of cells embedded in the scaffold. In this work, we present an approach that decouples the mechanical and biochemical needs and allows for the independent development of the structural and cellular niches in a scaffold. Using the highly tuned capabilities of digital light processing-based stereolithography, structures with complex architectures are achieved over a range of effective porosities and moduli. The 3D printed structure is infilled with mesenchymal stem cells and soft biomimetic hydrogels, which are specifically formulated with extracellular matrix analogs and tethered growth factors to provide selected biochemical cues for the guided differentiation towards chondrogenesis and osteogenesis. We demonstrate the ability to utilize these structures to (a) infill a focal chondral defect and mitigate macroscopic and cellular level changes in the cartilage surrounding the defect, and (b) support the development of a stratified multi-tissue scaffold for osteochondral tissue engineering.
Resist processes for hybrid (electron-beam/deep ultraviolet) lithography (1998)

This article describes the different mix and match writing strategies using both an optical deep ultraviolet (DUV) stepper (ASML/90) and an electron-beam (e-beam) system (LEICA VB6HR) with both positive and negative tone chemically amplified resists. These resists, mainly developed for DUV applications, have shown very good performance under e-beam exposure. Negative tone resists such as the Shipley XP90166 and UVN2, and positive tone resists such as the Shipley UVIII and UV5 have been optimized in terms of soft bake temperatures, postexposure bake temperatures, and development process. Resolutions in the range of 40–50 nm have been obtained using a 50 keV accelerating voltage. Delay time effect has been quantified and different behaviors under vacuum and in air have been pointed out.
The challenge of improving nitrogen use efficiency in crop plants: towards a more central role for genetic variability and quantitative genetics within integrated approaches (2007)

In this review, recent developments and future prospects of obtaining a better understanding of the regulation of nitrogen use efficiency in the main crop species cultivated in the world are presented. In these crops, an increased knowledge of the regulatory mechanisms controlling plant nitrogen economy is vital for improving nitrogen use efficiency and for reducing excessive input of fertilizers, while maintaining an acceptable yield. Using plants grown under agronomic conditions at low and high nitrogen fertilization regimes, it is now possible to develop whole-plant physiological studies combined with gene, protein, and metabolite profiling to build up a comprehensive picture depicting the different steps of nitrogen uptake, assimilation, and recycling to the final deposition in the seed. A critical overview is provided on how understanding of the physiological and molecular controls of N assimilation under varying environmental conditions in crops has been improved through the use of combined approaches, mainly based on whole-plant physiology, quantitative genetics, and forward and reverse genetics approaches. Current knowledge and prospects for future agronomic development and application for breeding crops adapted to lower fertilizer input are explored, taking into account the world economic and environmental constraints in the next century.
Aberration‐corrected microscopy and spectroscopy analysis of pristine, nitrogen containing detonation nanodiamond (Phys. Status Solidi A 10/2013) (2013)

Aberration-corrected transmission electron microscopy (TEM), electron energy-loss spectroscopy (EELS), and density functional theory (DFT) calculations are used by Turner et al. (pp. 1976–1984) to solve several key questions about the surface structure, the particle morphology, and the distribution and nature of nitrogen impurities in detonation nanodiamond. High-resolution TEM demonstrates the stability of ultrasmall nanodiamonds under electron illumination at low acceleration voltage and is used to image the surface structure of detonation nanodiamond. Highresolution EELS measurements on the fine structure of the carbon K-edge demonstrate that the typical π* pre-peak of nanodiamond in fact consists of three sub-peaks that arise from the presence of minimal fullerene-like reconstructions at the nanoparticle surfaces and deviations from perfect sp3 coordination at defects. Spatially resolved EELS experiments evidence the presence of nitrogen within the core of detonation nanodiamond particles. The nitrogen is present throughout the whole diamond core, and can be enriched at defect regions. By comparing the fine structure of the experimental nitrogen K-edge with calculated ELNES spectra from DFT, the embedded nitrogen is most likely related to single substitutional and/or A-center nitrogen, combined with larger nitrogen clusters.