gebhart/patrepeval huggingface dataset:
La double vie de la sérotonine ou quand la génétique découvre la physiologie (2010)

During the last 20 years, the emergence of sophisticated genetic tools has extraordinarily improved our understanding of a large number of physiological functions, among which the physiology of the skeleton. Bone, recently described as an endocrine organ, has the ability to constantly renew itself through bone remodeling, which requires a constant supply of energy. Hence, we hypothesized that there must be a coregulation of bone mass and energy metabolism, and focused on leptin, an adipocyte-derived hormone, which regulates both energy metabolism and bone remodeling through a central relay. Through a careful analysis of leptin neuronal targets, we unraveled that leptin regulation of bone mass occurs indirectly by inhibiting serotonin release and synthesis in neurons of the brainstem. Surprisingly, we observed that the other pool of serotonin, produced in enterochromaffin cells of the duodenum, negatively regulates bone mass accrual. Thus, serotonin is a molecule with two distinct functional identities depending on its site of synthesis. Finally, a recent study provides a proof of principle that inhibiting gut-derived serotonin (GDS) biosynthesis could become a new anabolic treatment for osteoporosis. double dagger.
Archaeological investigations of the Catalina wreck sites in East Arm, Darwin Harbour (1996)

Wreck inspections carried out by the Maritime Archaeology and History Section, Museum and Art Gallery of the Northern Territory (MAGNT) in 1995 were aimed at verifying a number of reported World War II (WW II) Catalina flying boat wreck sites in East Arm, Darwin Harbour. The origin of these reports is a publication called Wrecks in Darwin Waters produced by a high school teacher (Lewis, 1992), which mentions the positions of five Catalina wreck sites. However, Lewis' locations of these sites is questionable. He does not conclusively identify the Catalina wreck sites he refers to, except for one Royal Australian Air Force (RAAF) Catalina known as A24-1.
Application of Nonlinear Receptance Coupling to Dynamic Stiffness Evaluation for Reconfigurable Machine Tools (2001)

Abstract A systematic procedure is proposed to evaluate dynamic characteristics of design alternatives, for a Reconfigurable Machine Tool (RMT). The procedure is intended to be used in an automated design environment where various design alternatives are generated by kinematic synthesis based on a given task and specification. The evaluation procedure makes use of a substructuring method called nonlinear receptance coupling. The coupling method includes the effects of weakly nonlinear compliant joints through the use of describing functions for the nonlinearities involved. To demonstrate the utility of the proposed evaluation procedure design alternatives are generated based on a reduced order lumped parameter model of the RMT and examined with respect to the proposed criteria. It is shown that joint nonlinearities may affect dynamic stiffness considerably. It is also shown that the suggested criteria can distinguish various design alternatives with respect to their expected dynamic behavior.
Thermal accumulation effect in three-dimensional recording by picosecond pulses (2004)

In-bulk recording without cracking in borosilicate glass by high repetition rate (80 MHz) 12 ps pulses at 355 nm wavelength is demonstrated and discussed. The theoretical model of a “hot-line” scan and thermal accumulation qualitatively well describes the experimental results. The analytical expression of a thermally induced stress was obtained.
A Directional CSMA/CA Protocol for mmWave Wireless PANs (2010)

In this paper, we investigate the problem of medium access control in mmWave wireless personal area networks (WPAN), within which directional antennas are used to combat the high path loss incurred in the 60GHz frequency band. The conventional CSMA/CA protocol does not work well with directional antennas due to impaired carrier sensing at the transmitters. We explain why existing directional MAC protocols do not work well at 60GHz and propose a novel directional CSMA/CA protocol designed specifically for 60GHz WPANs. Instead of relying on physical carrier sensing, the proposed protocol adopts virtual carrier sensing and relies on a central coordinator to distribute network allocation vector (NAV) information. Both performance analysis and simulation study show that the proposed mechanism incurs low overhead and has robust performance even when the network is heavily congested.
On Normalizing Fuzzy Coincidence Matrices to Compare Fuzzy and/or Possibilistic Partitions with the Rand Index (2010)

Most already existing indices used to compare two strict partitions with different number of clusters are based on coincidence matrices. To extend such indices to fuzzy partitions, one can define fuzzy coincidence matrices by means of triangular norms. It has been shown this can require some kind of normalization to reinforce the corresponding indices. We propose in this paper a generic solution to perform this normalization considering the generators of the used triangular norms. Although the solution is not index-dependant, we focus on the Rand index and some of its fuzzy counterparts.
Proteômica para investigar a congelabilidade do semen bovino (2013)

The present study was undertaken the protein composition in 2D-electrophoretic pattern (2DE) of the seminal plasma (SP) can interfere in the semen bull freezability, and if we can use that for predicting semen bull freezability. Samples were obtained of 20 bulls (different breeds) with a minimum of 3 years history semen production in commercial semen collection Center. All animals ranged between 2 - 7 years of age. The semen freezability was calculated by # of thawed and approved ejaculates / # of ejaculates submitted to cryopreservation (after semen evaluation and approved to submitted to freeze). The bulls were divided in 3 groups: HIGH (=&gt;80% ejaculates approved); MEDIUM (&gt;60% and &lt;79% ejaculates approved); LOW (=&lt;59% ejaculates approved); the pattern and criteria were the same used in the routine of the commercial semen Center. 68 gels were carried through by 2DE of SP samples indicated 225 detected spots with protein different amount (VION) comparing. Comparing bull´s semen freezability and VION of each spot found difference among 2 spots from High and Low, even considering just spots with % of detection frequency bigger than 75%. The taurine bulls demonstrated more homogeneous profile when comparing with zebu bulls, considering number and frequency of appearance of spots. The results showed that proteomics can be a useful tool to predict the semen freezability, but we´ll need to study better the interactions between sperm membrane, seminal plasma and extender to comprehend better which proteome phenotype interfere positive or negatively in the semen freezability.
Chemical Synthesis of Ubiquitin Chains (2015)

Chemical synthesis of complex biomolecules such as proteins is a challenging adventure, yet rewarding in driving various biochemical and biophysical research activities. Over the years, the refinement of peptide synthesis and invention of ligation methodologies have led to the successful synthesis of several complex protein targets. Ubiquitin bioconjugates, which are being studied intensively by many groups due to their involvement in numerous biological processes, represent a fine example where chemistry is greatly aiding these studies. In this article, we describe the synthetic routes and strategies to prepare different ubiquitin analogs with desired modifications, as well as di-ubiquitin chains.
A phonetic dictionary for demisyllabic speech synthesis (1980)

Demisyllables and affixes (1,2,3) have been found to be very promising units for concatenative speech synthesis
Replicationin vitroof single-stranded DNA photosensitized by promazine derivatives (1984)

Promazine derivatives are photoreagents which initiate diversified photodamage to biomolecules (Kochevar, 1981) and are able to alter DNA with various efficiencies as it has been deduced from their lethal and mutagenic effects on OX 174 bacteriophage (Merville et al., 1983).
Land of Opportunity (2009)

ADVERTISEMENT RETURN TO ISSUEEditors LetterNEXTLand of OpportunityPeter H. SeebergerCite this: ACS Chem. Biol. 2009, 4, 8, 589–590Publication Date (Web):August 21, 2009Publication History Received29 July 2009Published online21 August 2009Published inissue 21 August 2009https://pubs.acs.org/doi/10.1021/cb900192phttps://doi.org/10.1021/cb900192peditorialACS PublicationsCopyright © 2009 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1170Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (63 KB) Get e-AlertscloseSUBJECTS:Biology,Chemical biology,Military science Get e-Alerts
COMPACT HANDHELD FRINGE PROJECTION BASED UNDERWATER 3D-SCANNER (2015)

Abstract. A new, fringe projection based compact handheld 3D scanner for the surface reconstruction of measurement objects under water is introduced. The weight of the scanner is about 10 kg and can be used in a water depth of maximal 40 metres. A measurement field of about 250 mm x 200 mm is covered under water, and the lateral resolution of the measured object points is about 150 μm. Larger measurement objects can be digitized in a unique geometric model by merging subsequently recorded datasets. The recording time for one 3D scan is a third of a second. The projection unit for the structured illumination of the scene as well as the computer for device control and measurement data analysis are included into the scanners housing. A display on the backside of the device realizes the graphical presentation of the current measurement data. It allows the user to evaluate the quality of the measurement result in real-time already during the recording of the measurement under water. For the calibration of the underwater scanner a combined method of air- and water-calibration was developed which needs only a few recorded underwater images of a plane surface and an object with known lengths. First measurement results obtained with the new scanner are presented.
Modified PAXgene™ method allows for isolation of high-integrity total RNA from microlitre volumes of mouse whole blood (2009)

Analysis of gene expression is often used to evaluate the effects of experimental manipulations in laboratory animals. Blood is a rich source of potential biomarkers, including gene expression information, which may be obtained from whole blood. When compared with the end of a study, when whole blood samples can be easily obtained for gene expression measurements, the limiting volumes of whole blood obtainable from animals during the course of an experiment requires a method for RNA isolation from a minimal volume of whole blood. The PAXgene Blood RNA Extraction System originally designed for isolation of total RNA from 2.5 mL of human whole blood, was modified and successfully used to isolate high-integrity total RNA from as little as 50 microL of mouse whole blood. Fifty microlitres of mouse whole blood yielded an average of 2.3 microg highly intact total RNA, of sufficient quality and quantity allowing for multiple gene expression determinations. The utility of this method was demonstrated by confirming the time- and dose-dependent upregulation of haem oxygenase-1 (Hmox1) mRNA in response to a single injection of cobalt protoporphyrin. The successful isolation of total RNA from small volumes of mouse whole blood can allow for serial sampling on the same animals, thereby reducing the number of animals required for experimentation.
Micro Cantilever-Based Optical Gravimeter (2021)

Geophysical phenomena like volcanic eruptions, tectonic plate movements, and earthquakes directly influence the gravitational pull in the region of occurrence. Measurement of anomalies in the gravitational pull has been a useful technique in analyzing such activities quantitatively. Gravitational variations also carry indications of the presence of the earth’s minerals and other such useful resources. In this paper, a novel on-chip micro-cantilever-based optical gravimeter has been proposed for the precise measurement of gravitational changes. Simulations comprising both three-dimensional full-vector finite element and finite difference time domain methods have been carried out for analyses, demonstrating an extensive reading range of 6000 mGal with a resolution of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1.17~\mu $ </tex-math></inline-formula> Gal and sensitivity of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1~\mu $ </tex-math></inline-formula> Gal/ <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sqrt {Hz}$ </tex-math></inline-formula> at 1 Hz.
A two-year analysis of DRG #288, procedures for obesity. (1987)

DRG #288 is composed of operative procedures performed for obesity, both gastric and plastic. A two-year cost analysis of 103 consecutive gastric reduction operations performed for morbid obesity was conducted at Robert Wood Johnson University Hospital. It showed a net loss to the hospital of $18,033 in 1984 and $24,126 in 1985. Although the mean length of stay was 1.43 days less in 1985 than in 1984, DRG #288 was still a money loser. A detailed cost breakdown of nine active cost-center categories showed large financial disincentives (losses) in surgical supplies, OR/recovery room time and X ray utilization during both years of the study. These losses were not offset by substantial profits in the room-and-board category, which is directly related to length of stay. It is intuitively obvious that plastic surgical procedures for obesity require less expensive surgical supplies, fewer X rays, and shorter OR/recovery room times than gastrointestinal operations performed for morbid obesity. We conclude that DRG #288 is improperly constructed because it contains a clinically incoherent, heterogeneous mixture of operations that cannot be expected to consume similar amounts of resources and incur similar costs. Hospitals in which the preponderance of operations performed for obesity are gastrointestinal as opposed to plastic are inherently penalized by the current aggregation of DRG #288.
Isolation and Quantification of Ginsenoside Rh23, a New Anti-Melanogenic Compound from the Leaves of Panax ginseng (2018)

A new ginsenoside, named ginsenoside Rh23 (<b>1</b>), and 20-<i>O</i>-β-d-glucopyranosyl-3β,6α,12β,20β,25-pentahydroxydammar-23-ene (<b>2</b>) were isolated from the leaves of hydroponic <i>Panax ginseng</i>. Compounds were isolated by various column chromatography and their structures were determined based on spectroscopic methods, including high resolution quadrupole/time of flight mass spectrometry (HR-QTOF/MS), nuclear magnetic resonance (NMR) spectroscopy, and infrared (IR) spectroscopy. To determine anti-melanogenic activity, the change in the melanin content in melan-a cells treated with identified compounds was tested. Additionally, we investigated the melanin inhibitory effects of ginsenoside Rh23 on pigmentation in a zebrafish in vivo model. Compound <b>1</b> inhibited potent melanogenesis in melan-a cells with 37.0% melanogenesis inhibition at 80 µM and also presented inhibition on the body pigmentation in zebrafish model. Although compound <b>2</b> showed slightly lower inhibitory activity than compound <b>1</b>, it also showed significantly decreased melanogenesis in melan-a cell and in zebrafish model. These results indicated that compounds isolated from hydroponic <i>P. ginseng</i> may be used as new skin whitening compound through the in vitro and in vivo systems. Furthermore, this study demonstrated the utility of MS-based compound <b>1</b> for the quantitative analysis. Ginsenoside Rh23 (<b>1</b>) was found at a level of 0.31 mg/g in leaves of hydroponic <i>P. ginseng</i>.
Structural and aerodynamic considerations for an oblique all-wing aircraft (1992)

A key design issue for the Oblique All-Wing aircraft is the packaging of the payload compartment, the fuel tanks, and the other internal components within the airfoil. The internal arrangement of such vehicles is strongly coupled to the exterior vehicle geometry. For example, the height requirements of a passenger cabin directly influence the aircraft thickness and span. As a result, the internal arrangement strongly affects aerodynamic performance and structural weight. Configuration criteria are defined and/or discussed, and a baseline aircraft is developed. Also, some of the major tradeoffs that affect structural weight and aerodynamic performance are presented.
The Fc Segment of IgE Influences the Kinetics of Dissociation of a Symmetrical Bivalent Ligand from Cyclic Dimeric Complexes (1996)

As part of a systematic effort to determine the features of immunoglobulin E-receptor (IgE-Fc epsilon RI) aggregation that are critical for cellular activation, we used fluorescence to examine the dissociation of a soluble bivalent ligand, N, N'-bis[[epsilon-[(2,4-dinitrophenyl)amino]caproyl]-L-tyrosyl]-L-cystine ((DCT)2-cys), from soluble bivalent IgE and its bivalent F(ab')2 and monovalent Fab' fragments. Cross-linking of Fab' fragments by (DCT)2-cys is limited to linear dimers, and we find that (DCT)2-cys dissociation from Fab' occurs with a single kinetic coefficient [(4.2 +/- 0.6) x 10-3 s-1] that corresponds to the lower of the two kinetic coefficients observed with the bivalent IgE [(4.7 +/- 0.7) x 10-2 s-1 and (4.4 +/- 0.3) x 10-3 s-1]. Similarly, the lower value is obtained for dissociation of (DCT)2-cys that is monovalently bound to IgE after incubation with a large excess of the ligand. (DCT)2-cys can bind to bivalent F(ab')2 fragments and form a variety of linear and cyclic aggregates, similarly to IgE, but, unlike IgE, we find that dissociation occurs with a single kinetic coefficient similar to that observed for Fab'. We find that IgE and its (Fab')2 fragments form highly stable cyclic dimer rings with two (DCT)2-cys. We demonstrate that the kinetic coefficients are independent of enhanced fluorescence quenching observed for bound sites in cyclic dimers. Together, the results show that the rate constant for breaking a linear cross-link formed by (DCT)2-cys is the same as that for dissociation of the monovalently bound (DCT)2-cys. Further, they show that opening of a bond in a dimer ring for the F(ab')2 fragment occurs with approximately the same dissociation rate constant as opening a bond in a linear cross-link. This rate constant is about three times smaller than that observed with IgE, suggesting that steric strain is caused by apposed Fc segments in cyclic IgE dimers. Such structural interference may affect the functional consequences of IgE-Fc epsilon RI aggregation on the cell surface.
Research Progress of Producing Magnesium Hydroxide from Salt Lake (2010)

The research reviewed the characteristics of magnesium resources in salt lake.Better utilize the magnesium resources in salt lake can be used to achieve immense economic interest and eliminate contamination caused to resources.Based on the domestic and foreign actual conditions of the salt lake resource's utilization and the author of the research,this paper introduced the central production process about magnesium hydroxide using the magnesium resources in salt lake.
Phoenix-XNS - A Miniature Real-Time Navigation System for LEO Satellites (2006)

The paper describes the development of a miniature GPS receiver with integrated real-time navigation system for orbit determination of satellites in low Earth orbit (LEO). The Phoenix-XNS receiver is based on a commercial-off-the-shelf (COTS) single-frequency GPS receiver board that has been qualified for use in a moderate space environment. Its firmware is specifically designed for space applications and accounts for the high signal dynamics in the acquisition and tracking process. The supplementary eXtended Navigation System (XNS) employs an elaborate force model and a 24-state Kalman filter to provide a smooth and continuous reduced-dynamics navigation solution even in case of restricted GPS availability. Through the use of the GRAPHIC code-carrier combination, ionospheric path delays can be fully eliminated in the filter, which overcomes the main limitation of conventional single-frequency receivers. Tests conducted in a signal simulator test bed have demonstrated a filtered navigation solution accuracy of better than 1 m (3D rms).
Direct observation of non-Gaussian distribution of local magnetic properties in ferromagnetic thin films (2002)

We report our experimental finding that magnetic properties of Co-based multilayer films are shown to exhibit their local variations far from the Gaussian (or Lorentzian) distribution which are usually assumed. The local variations of the coercivity and the field dependence $\ensuremath{\lambda}(=\ensuremath{-}\ensuremath{\partial}\mathrm{ln}\ensuremath{\tau}/\ensuremath{\partial}H)$ were determined from measurements of the hysteresis loop and the field-dependent switching time \ensuremath{\tau}, respectively, on spatially resolved local regions 400 nm in size by means of a magneto-optical microscope magnetometer. We show that the two local magnetic properties inversely correlate with each other and a thermally activated process takes place during magnetization reversal on a submicrometer scale in ferromagnetic thin films.
CCNet: Criss-Cross Attention for Semantic Segmentation (2020)

Contextual information is vital in visual understanding problems, such as semantic segmentation and object detection. We propose a criss-cross network (CCNet) for obtaining full-image contextual information in a very effective and efficient way. Concretely, for each pixel, a novel criss-cross attention module harvests the contextual information of all the pixels on its criss-cross path. By taking a further recurrent operation, each pixel can finally capture the full-image dependencies. Besides, a category consistent loss is proposed to enforce the criss-cross attention module to produce more discriminative features. Overall, CCNet is with the following merits: 1) GPU memory friendly. Compared with the non-local block, the proposed recurrent criss-cross attention module requires 11× less GPU memory usage. 2) High computational efficiency. The recurrent criss-cross attention significantly reduces FLOPs by about 85 percent of the non-local block. 3) The state-of-the-art performance. We conduct extensive experiments on semantic segmentation benchmarks including Cityscapes, ADE20K, human parsing benchmark LIP, instance segmentation benchmark COCO, video segmentation benchmark CamVid. In particular, our CCNet achieves the mIoU scores of 81.9, 45.76 and 55.47 percent on the Cityscapes test set, the ADE20K validation set and the LIP validation set respectively, which are the new state-of-the-art results. The source codes are available at https://github.com/speedinghzl/CCNethttps://github.com/speedinghzl/CCNet.