gebhart/patrepeval huggingface dataset:
Amniotic membrane transplantation in a patient with an impending perforated corneal ulcer caused by Streptococcus mitis: a case report (2019)

Abstract Background: Streptococcus mitis (S. mitis) belongs to the viridans group streptococci, which is rarely isolated as a causative pathogen of corneal ulcers. When S. mitis causes keratitis, penetrating keratoplasty (PK) might be necessary. Herein, we demonstrated that amniotic membrane transplantation (AMT) may be an easier procedure with acceptable outcomes and with fewer complications. Case presentation: A 63-year-old female presented with a right persistent corneal ulcer that she had suffered from for the past nine months. The culture of a corneal scraping yielded S. mitis. The right eye descemetocele decreased from 3 mm in diameter to 0.8 mm in diameter after the continuous administration of topical vancomycin and ceftriaxone for two weeks. Due to the slow healing, AMT was performed. Her corneal erosion healed and gradually became clear. Her visual acuity recovered from initially counting fingers to 20/200 17 months after AMT. Conclusion: This unusual case illustrated that antibiotics plus AMT may be an effective alternative treatment instead of PK to promote epithelialization and to reduce inflammation in corneas complicated by S. mitis keratitis.
Use of Aspirin postdiagnosis improves survival for colon cancer patients (2012)

Aspirin use initiated or continued after diagnosis of colon cancer is associated with a lower risk of overall mortality. These findings strongly support initiation of a placebo-controlled trial that investigates the role of aspirin as adjuvant treatment in colon cancer patients.
New Technique of Bleaching Photographic Emulsions and Its Application to Holography (1972)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Thiry, "New Technique of Bleaching Photographic Emulsions and Its Application to Holography," Appl. Opt. 11, 1652-1653 (1972) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Using Realistic Simulation to Identify I/O Bottlenecks in MapReduce Setups (2008)

The exponentially growing data demands of modern enterprise and scientific applications poses critical challenges in sustaining the applications at scale. The MapReduce [1] programming model has served as the key enabler for executing resource-intensive applications over huge datasets. However, its configuration design-space has not been studied in detail. This is a complex problem as a typical MapReduce configuration can encompass hundreds of parameters, e.g., node configuration (number of disks and compute capacity), network topology (inter and intra-rack), choice of file system, data partitioning and layout, types of schedulers, etc – all of which affect application performance. While empirical insights for certain specific configurations, e.g., Google’s MapReduce infrastructure [1], do exist, they cannot be simply extended to other setups. Moreover, no tool or model is available to the community for studyingMapReduce application performance. In this work, we explore how choices about cluster design, run-time parameters, multi-tenancy and application design, affect I/O patterns, network communication and performance of MapReduce applications. Since the scale of the system precludes using actual machines for this exploration, we are developing an accurate MapReduce simulator, Dumbo, to facilitate performance analysis. The insights gained through Dumbo will be useful in comprehending the factors that affect MapReduce application performance. We expect Dumbo to be used by researchers and practitioners to understand how their MapReduce applications will behave on a particular configuration, and how they can improve the applications and platforms to optimize performance. Dumbo, used as a planning tool, will make MapReduce deployment far easier by reducing the number of parameters that currently have to be hand-tuned using trial-and-error and rules of thumb.
Involvement of cAMP/EPAC/TRPM2 Activation in Glucose- and Incretin-Induced Insulin Secretion (2014)

In pancreatic β-cells, closure of the ATP-sensitive K(+) (K(ATP)) channel is an initial process triggering glucose-stimulated insulin secretion. In addition, constitutive opening of background nonselective cation channels (NSCCs) is essentially required to effectively evoke depolarization as a consequence of K(ATP) channel closure. Thus, it is hypothesized that further opening of NSCC facilitates membrane excitability. We identified a class of NSCC that was activated by exendin (ex)-4, GLP-1, and its analog liraglutide at picomolar levels. This NSCC was also activated by increasing the glucose concentration. NSCC activation by glucose and GLP-1 was a consequence of the activated cAMP/EPAC-mediated pathway and was attenuated in TRPM2-deficient mice. The NSCC was not activated by protein kinase A (PKA) activators and was activated by ex-4 in the presence of PKA inhibitors. These results suggest that glucose- and incretin-activated NSCC (TRPM2) works in concert with closure of the KATP channel to effectively induce membrane depolarization to initiate insulin secretion. The current study reveals a new mechanism for regulating electrical excitability in β-cells and for mediating the action of glucose and incretin to evoke insulin secretion, thereby providing an innovative target for the treatment of type 2 diabetes.
Confocal Raman microscopic investigation of the effectiveness of penetration enhancers for procaine delivery to the skin (2014)

A methodology that employs confocal Raman microscopy (CRM) on ex vivo skin samples is proposed for the investigation of drug content and distribution in the skin. To this end, the influence of the penetration enhancers propylene glycol and polyoxyethylene-23-lauryl ether on the penetration and permeation of procaine as a model substance was investigated. The drug content of skin samples that had been incubated with semisolid formulations containing one of these enhancers was examined after skin segmentation. The experiments showed that propylene glycol did not affect the procaine content that was delivered to the skin, whereas polyoxyethylene-23-lauryl ether led to higher procaine contents and deeper penetration. Neither substance was found to influence the permeation rate of procaine. It is thereby shown that CRM can provide additional information on drug penetration and permeation. Furthermore, the method was found to enhance the depth from which Raman spectra can be collected and to improve the depth resolution compared to previously proposed methods.
Newborn piglet model for campylobacteriosis (1993)

An in vivo model system for human campylobacteriosis has been developed in which colostrum-deprived newborn piglets are orally challenged with an invasive strain of Campylobacter jejuni. Piglets developed clinical symptoms and histopathological lesions similar to those observed in humans infected with C. jejuni. Gross lesion examination at autopsy revealed the presence of edema, hyperemia, and mucus. Histopathologic examinations by light and transmission electron microscopy demonstrated damage to surface epithelial cells with the presence of intracellular bacteria, mainly in the large intestine. Similar lesions were not demonstrated in control piglets.
Supplementary material to "Influence of urban pollution on the production of organic particulate matter from isoprene epoxydiols in central Amazonia" (2016)

Online measurements of organic and sulfate mass concentrations measured in this study were made by a High-Resolution Time-of-Flight Aerosol Mass Spectrometer (AMS, Aerodyne Research Inc.) The AMS provided real-time measurements of bulk non-refractory particle chemical composition (organic, sulfate, nitrate, ammonium, chloride) and chemically resolved mass-diameter distribution. Air was sampled through a critical orifice and enters an aerodynamic lens, which focused the submicron particles into a narrow beam Particles traveled through a sizing chamber to reach a porous tungsten inverted-cone vaporizer at 600 C, and non-refractory components volatilized.
The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor (2000)

Peptides associated with the heat shock protein gp96 induce a specific T cell response against cells from which gp96 is isolated. Recently, we have shown that gp96 binds to a yet unknown receptor present on dendritic cells (DC) and that receptor-mediated uptake is required for cross-presentation of gp96-associated peptides by DC. We now describe that gp96 mediates maturation of DC as determined by up-regulation of MHC class II and CD86 molecules, secretion of the cytokines IL-12 and TNF-alpha and enhanced T cell stimulatory capacity. Heat-denatured gp96 is not able to induce DC maturation and cytokine secretion. Furthermore, we show that mature DC are no longer able to bind gp96 molecules. Hence, the gp96 receptor is down-regulated on mature DC, suggesting that this receptor behaves similar to other receptors involved in antigen uptake like the scavenger receptor CD36, the mannose receptor or the integrins alpha(v)beta(3) and alpha(v)beta(5). Together, our findings provide an additional explanation for the remarkable immunogenicity of gp96 as a cross-priming antigen carrier and direct activator of DC.
Gene set variation analysis of mRNA expression in bronchial biopsies from the U-BIOPRED asthma study (2014)

Improving our understanding of the molecular pathways involved in asthma may facilitate better stratification of endotypes. The aim of the present study was to apply Gene Set Variation Analysis to microarray data from the U-BIOPRED cohort, in order to estimate the variation of specific gene sets in asthma. Endobronchial biopsies from 150 subjects distributed between mild-moderate, smoker and non-smoker severe asthma, and healthy controls were analysed. We utilised gene signatures of distinct immune cell type activation, of response to therapy, from different tissues and diseases. Signature enrichment in patient transcriptomes can be represented as a dot plot. The natural killer (NK) signature is equally distributed across cohorts except for an evident split in the non-smoker severe asthma group revealing potential patient subgroups (Figure 1, upper panel). The Th2 signature is elevated in subsets of each cohort (Figure 1, lower panel). Enrichment scores can be subjected to further classical statistical analysis to explore association with clinical features. We conclude that the use of gene signature variation for patient stratification provides an alternative to classical differential gene and pathway expression analysis, which aim to identify differences between predefined patient subgroups. Our preliminary results demonstrate immune pathology subsets in asthma patients. This work was funded by IMI.
Returning to health visiting (1995)

Dear Editor After a six-and-a-half year break I have returned to health visiting. I went back to the same caseload. In the meantime, while I had been childrearing and spasmodically working as a bank health visitor in three health districts and trusts, the practice had become fundholding.
Half-life ofTh230 (1980)

The half-life of $^{230}\mathrm{Th}$ was measured by the specific activity method. Alpha counting was done in a low geometry counter whose geometry factor was calculated from its dimensions. Sample weights were determined by isotopic dilution. Measurements were made on four isotopic mixtures ranging from 0.383 to 99.52% $^{230}\mathrm{Th}$. The half-life is 75381\ifmmode\pm\else\textpm\fi{}295 years.RADIOACTIVITY $^{230}\mathrm{Th}$ half-life, specific activity; measured: $\ensuremath{\alpha}$ activity by low geometry counter, thorium mass by mass spectrometric isotopic dilution.
Epitope mapping of pathogenicLeptospiraLipL32 (2009)

This finding could have potential relevance not only for serodiagnosis but also as a starting point for the characterization of targets for vaccine design.
Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis (2015)

Single-cell analysis technologies such as mass cytometry allow for measurements of cellular heterogeneity with unprecedented dimensionality. Here, we applied dimensionality reduction and automated clustering methods on human T helper (T(H)) cells derived from peripheral blood and tonsils, which showed differential cell composition and extensive T(H) cell heterogeneity. Notably, this analysis revealed numerous subtypes of follicular helper T (T(FH)) cells that followed a continuum spanning both blood and tonsils. Furthermore, we identified tonsillar CXCR5(lo)PD-1(lo)CCR7(lo) T(FH) cells expressing interferon-γ (IFN-γ), interleukin-17 (IL-17), or Foxp3, indicating that T(FH) cells exhibit diverse functional capacities within extrafollicular stages. Regression analysis demonstrated that CXCR5(lo)PD-1(-) and CXCR5(lo)PD-1(lo) cells accumulate during childhood in secondary lymphoid organs, supporting previous findings that these subsets represent memory T(FH) cells. This study provides an in-depth comparison of human blood and tonsillar T(FH) cells and outlines a general approach for subset discovery and hypothesizing of cellular progressions.
Convergence of a method for solving the magnetostatic field in nonlinear media (1968)

For solving the boundary-value problem for potential of a stationary magnetic field in two dimensions in ferromagnetics it is possible to use a linearization based on the succesive approximations. In this paper the convergence of this method is proved under some conditions.
Electrical Properties of Pulsed Laser Crystallized Silicon Films (1999)

Electrical properties of phosphorus-doped laser-crystallized silicon films were investigated. The analysis of free carrier optical absorption revealed that crystalline grains formed at laser energies of 360–375 mJ/cm 2 had high carrier mobilities of 40–50 cm 2 /Vs, which were close to that of doped single crystalline silicon. The mobility did not depend on the number of laser pulses. On the other hand, Hall effect measurements showed a marked increase in the carrier mobility of electrical current traversing grain boundaries from 3 to 28 cm 2 /Vs as the laser energy density increased from 160 to 375 mJ/cm 2 . The Hall mobility also increased as the number of laser pulses increased, although a single pulse irradiation resulted in a maximum carrier mobility of 15 cm 2 /Vs. These results suggest that a high laser energy density as well as numbers of multiple pulses are necessary to reduce disordered amorphous states and improve grain boundary properties.
Management of composite tibial and soft tissue defects via intramedullary bone transport devices and microvascular free flaps: A treatment algorithm and presentation of two cases (2023)

ABSTRACT Background: Tibial malunion and nonunion are complications that may follow the repair of traumatic tibial shaft fractures. Management may sometime require osteotomy and bone transport. In recent years, there has been a paradigm shift in the management of intercalary tibial defects away from bone transport via external fixation towards intramedullary lengthening nails. This shift necessitates a re-evaluation of the approach to infection and soft tissue defects. Cases: We describe the case of a young man with a two-year history of infected tibial nonunion who underwent osteotomy and debridement before requiring free tissue transfer and eventual bone transport. Second, we present the case of a middle-aged man with a 30-year history of infected tibial malunion. Prior to placement of the intramedullary nail, debridement and osteotomy were performed, followed by two free anterolateral thigh flaps and tissue rearrangement. Discussion: The use of free tissue transfers and emphasis on achieving an anatomically correct lower extremity prior to the initiation of bone transport resulted in minimal external fixation time, treatment compliance, and satisfactory clinical outcomes. Although multiple treatments can produce successful bone transport, no cohesive treatment algorithm exists that addresses infection, external fixation time, healing, and psychological burden. Conclusion: The paradigm shift towards intramedullary bone transport devices requires the use of antibiotic implants and prioritization of the soft tissue envelope prior to device implantation to prevent hardware infection and reoperation. An algorithmic management approach by an orthoplastic surgical team that includes an orthopedic surgeon and microsurgeon is recommended. Highlights:
SUPPLEMENTARY FIGURE 1. Primary CD138+-myeloma cells in bone marrow aspirates express αvβ3/αvβ5 integrins and IGF1R. from Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by Synstatin<sub>IGF1R</sub> Inhibits Tumor Growth (2023)

&lt;p&gt;Bone marrow aspirates from 12 individual patients were incubated on Sdc1 antibody to capture CD138+ myeloma cells and exclude other cell types present in the aspirates. Captured cells were fixed and stained for αvβ3 (LM609), αvβ5 (P1F6), or IGF1R (JBW902). Stained cells were counted and expressed as a percentage of total captured cells. Data points represent the mean of a minimum of four replicates for each patient.&lt;/p&gt;
Stable Gain Scheduling Through Bumpless Transfer (2005)

In this paper, a method of interpolating a priori designed controllers for gain scheduling using notions developed in anti-windup and bumpless transfer is discussed. In contrast with many approaches that guarantee stability by design of of the controllers as a set, it is often desirable to design and tune each controller individually and gain schedule the resulting controllers. Using the bumpless transfer techniques discussed, this paper puts forth a method of scheduling the controllers in a stable manner for sufficiently slow scheduling variables.
Genetic Analysis of HIV Type 1 Strains in Bujumbura (Burundi): Predominance of Subtype C Variant (2001)

In order to characterize the HIV-1 strains circulating in Burundi, 18 blood samples from nontreated patients were collected in Bujumbura and viral DNA and RNA were sequenced in the env and pol genes, respectively. The phylogenetic analysis of the V3 coding region of HIV-1 gp120 revealed that 83% (15/18) of the isolates belonged to the C subtype. The RT and protease coding regions of the pol gene also clustered with subtype C. A potential A/C recombinant between the protease (subtype A) and the RT and V3 coding regions (both subtype C) was identified. Drug resistance mutations were not detected in the RT gene. However, mutation M36I, associated with resistance to ritonavir and nelfinavir, was found in 17 of 18 Burundi isolates. In conclusion, this first characterization of HIV-1 strains circulating in Burundi confirms the dramatic emergence of subtype C in East Africa.
Integrated micro systems for DNA/protein and cell analysis (2004)

Summary form only given. We describe some novel integrated analysis methods for DNA / protein or cells employing micro chamber array.
ChemInform Abstract: Zirconocene‐Promoted Stereoselective Bicyclization of 1,6‐ and 1,7‐Dienes to Produce trans‐Zirconabicyclo(3.3.0)octanes and cis‐Zirconabicyclo(4.3.0)nonanes. (1990)

Abstract The α,ω‐dienes (Ia) ‐ (Id) react with the zirconocene (II) to give the fused zirconacyclopentane derivatives (III).
Robinsoniella peoriensis infection following surgery for scoliosis: a case report (2012)

We discuss similar cases suggesting that R. peoriensis is responsible for health care-associated infections with the colonic flora as a potential source of infection.
MRT mit T2*-Mapping zur Beurteilung einer Eiseneinlagerung in Milz und Pankreas bei Patienten mit diffuser Eisenspeichererkrankung (2013)

Ziele: Ziel ist es die Wertigkeit der Magnetresonanztomografie (MRT) unter Verwendung von T2*-Mapping in der Beurteilung einer pathologischen Eisenüberladung (pFe) der Milz und des Pankreas zu evaluieren. Methode: Insgesamt wurden 239 Patienten, bei denen aufgrund des klinischen Verdachtes auf eine diffuse Lebererkrankung eine MRT durchgeführt wurde, in diese Studie eingeschlossen und analysiert. 75 Patienten wurden aufgrund einer fehlenden Eisenspeichererkrankung aus der Studie ausgeschlossen. Bei 164 Patienten konnte eine Eisenspeichererkrankung der Leber nachgewiesen werden. Die T2*-Relaxationszeit von Milz und Pankreas wurde in identischen "regions of interest" (ROI's) mit einer Multi-Echo-Gradienten-Echo-Sequenz mit 12 Echos (TR = 200 ms; TE = 0,99 ms+n*1,41 ms; Flipwinkel: 20°) mit Fettsättigung gemessen. Zum Vergleich wurden die aus der Literatur bekannten Normalwerte der T2*-Relaxationszeiten herangezogen. Ergebnis: Bei Patienten mit einer pFe der Leber konnte ein signifikanter Unterschied (p = 0,02) zwischen jenen mit eisenfreien Pankreas (median T2*= 13,00) und Patienten mit zusätzlicher pathologischer Eisenüberladung des Pankreas (median T2*= 3,40) gemessen werden. Es konnte ebenfalls ein signifikanter Unterschied (p = 0,0155) zwischen Patienten mit kombinierter pFe von Leber und Milz (median T2*= 11,08) im Vergleich zu Patienten mit einer pFe von Leber, Milz und Pankreas (median T2*= 3,40) festgestellt werden. Kein signifikanter Unterschied (p = 0,399) lag zwischen Patienten mit einer pFe der Leber (median T2*= 13,00) und Patienten mit einer kobinierten pFe von Leber und Milz (median T2*= 11,08) vor. Schlussfolgerung: Die Ergebnisse unserer Studie verdeutlichen den Zusammenhang zwischen einer pFe der Leber und einer entsprechenden Beteiligung von Milz und Pankreas bei Patienten mit einer bekannten Eisenspeichererkrankung.
Quantitative assessment of BRAF V600 mutant cell-free tumor DNA from plasma as a diagnostic and therapeutic biomarker in pts with BRAF V600 mutant melanoma. (2015)

9015 Background: Analysis of BRAF V600 mutant cell-free tumor DNA (ctDNA) from plasma is under consideration as a biomarker in pts with advanced melanoma. Methods: Plasma samples were obtained from pts with advanced melanoma who participated in 3 prospective clinical trials. Quantitative allele-specific PCR analysis for BRAF V600 E/E2/D/K/R/M mutations was performed on cell-free DNA extracted from 1ml plasma (Idylla, Biocartis). Results: From 2/2014 to 12/2014, 232 plasma samples from 41 pts were analyzed. Detection of BRAF V600 mutant ctDNA at the time of diagnosis of metastatic disease was concordant with tumor tissue analysis in 100% of pts (BRAF mutant 3/10, BRAF wt 7/10). In the 3 BRAF mutant pts, ctDNA results preceded tissue results with a median of 40 days (14-93). Therapeutic monitoring of BRAF mutant ctDNA was performed in 33 pts (median of 7 analyses per pt [range 2-13]; median follow up of 4.8 months [0.5-9]). Treatment consisted of BRAF/MEK targeted therapy (n = 26 pts), ipilimumab (n = 5) or pembrolizumab (n = 9). In the 6 pts who had a detectable BRAF mutant ctDNA fraction (range 7-53%) at initiation of BRAF/MEK targeted therapy, the BRAF mutant ctDNA fraction became undetectable (n = 5) or < 1% (n = 1) after a median of 14 days (5-40) notwithstanding the absence of radiological CR. During BRAF/MEK targeted therapy, an increase in the BRAF mutant ctDNA fraction was detected prior to PD on imaging in 7/12 pts (58%; median interval of 1.1 month [0.8-1.7]) and concomitantly with PD on imaging in 2/12 pts (17%). An increase in BRAF mutant ctDNA fraction predicted PD during the following month in 67% of cases (n = 14/21, p < 0.001) and in 100% of cases within the following 2 months (n = 21/21, p < 0.001). Undetectable BRAF mutant ctDNA predicted absence of PD in the following month in 91% of analyses (n = 94/103; p < 0.001) and in the following 2 months in 83% of analyses (n = 77/93; p < 0.001). Conclusions: Analysis of BRAF mutant ctDNA from plasma allows for a rapid diagnosis of the BRAF status in pts with advanced melanoma. BRAF mutant ctDNA likely reflects the BRAF mutant proliferative tumor burden and holds promise as a therapeutic monitoring tool for pts with advanced BRAF V600 mutant melanoma.