gebhart/patrepeval huggingface dataset:
Hydrophile-lipophile balance (hlb) of fluorocarbon surfactants and its relation to the critical micelle concentration (cmc) (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrophile-lipophile balance (hlb) of fluorocarbon surfactants and its relation to the critical micelle concentration (cmc)I. J. LinCite this: J. Phys. Chem. 1972, 76, 14, 2019–2023Publication Date (Print):July 1, 1972Publication History Published online1 May 2002Published inissue 1 July 1972https://pubs.acs.org/doi/10.1021/j100658a020https://doi.org/10.1021/j100658a020research-articleACS PublicationsRequest reuse permissionsArticle Views687Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3 (2014)

Many neurodegenerative disorders present with sensory loss. In the group of hereditary sensory and autonomic neuropathies loss of nociception is one of the disease hallmarks. To determine underlying factors of sensory neurodegeneration we performed whole-exome sequencing in affected individuals with the disorder. In a family with sensory neuropathy with loss of pain perception and destruction of the pedal skeleton we report a missense mutation in a highly conserved amino acid residue of atlastin GTPase 3 (ATL3), an endoplasmic reticulum-shaping GTPase. The same mutation (p.Tyr192Cys) was identified in a second family with similar clinical outcome by screening a large cohort of 115 patients with hereditary sensory and autonomic neuropathies. Both families show an autosomal dominant pattern of inheritance and the mutation segregates with complete penetrance. ATL3 is a paralogue of ATL1, a membrane curvature-generating molecule that is involved in spastic paraplegia and hereditary sensory neuropathy. ATL3 proteins are enriched in three-way junctions, branch points of the endoplasmic reticulum that connect membranous tubules to a continuous network. Mutant ATL3 p.Tyr192Cys fails to localize to branch points, but instead disrupts the structure of the tubular endoplasmic reticulum, suggesting that the mutation exerts a dominant-negative effect. Identification of ATL3 as novel disease-associated gene exemplifies that long-term sensory neuronal maintenance critically depends on the structural organisation of the endoplasmic reticulum. It emphasizes that alterations in membrane shaping-proteins are one of the major emerging pathways in axonal degeneration and suggests that this group of molecules should be considered in neuroprotective strategies.
Ruthenium tetroxide oxidation of N-acylated alkylamines : A new general synthesis of imides. (1987)

Oxidation of various N-acylalkylamines with ruthenium tetroxide (RuO4) was systematically investigated. N-Acylalkylamines having an electron-donating group at the α-or β-position with respect to amide nitrogen or an electron-donating alkyl function in the acyl group were smoothly oxidized to the corresponding imides in excellent yields. On the other hand, N-acylalkylamines having an electron-withdrawing group were not oxidized at all, and most of the starting material was recovered. It appears that the reactivity of N-acylalkylamines is closely correlated with the acidity of the carboxylic acid from which the N-acyl group is derived, and also with the electron density at the methylene moiety adjacent to the amide nitrogen atom.
Ozonolysis of substituted uracils (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOzonolysis of substituted uracilsMasaki Matsui, Kazusaki Kamiya, Katsuyoshi Shibata, Hiroshige Muramatsu, and Hiroyuki NakazumiCite this: J. Org. Chem. 1990, 55, 4, 1396–1399Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/jo00291a062https://doi.org/10.1021/jo00291a062research-articleACS PublicationsRequest reuse permissionsArticle Views388Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R (2013)

The phosphoinositide 3-kinase (PI3K) signaling cascade is a key mediator of cellular growth, survival and metabolism and is frequently subverted in human cancer. The gene encoding for the alpha catalytic subunit of PI3K (PIK3CA) is mutated and/or amplified in ∼30% of breast cancers. Mutations in either the kinase domain (H1047R) or the helical domain (E545K) are most common and result in a constitutively active enzyme with oncogenic capacity. PIK3CA(H1047R) was previously demonstrated to induce tumors in transgenic mouse models; however, it was not known whether overexpression of PIK3CA(E545K) is sufficient to induce mammary tumors and whether tumor initiation by these two types of mutants differs. Here, we demonstrate that expression of PIK3CA(E545K) in the mouse mammary gland induces heterogenous mammary carcinomas but with a longer latency than PIK3CA(H1047R)-expressing mice. Our results suggest that the helical domain mutant PIK3CA(E545K) is a less potent inducer of mammary tumors due to less efficient activation of downstream Akt signaling.
Reaktionen mit Cyclobutendionen, V. Über die Umsetzung von 2‐Brom‐1‐phenyl‐cyclobuten‐(1)‐dion‐(3.4) mit primären, sekundären und tertiären aromatischen Monoaminen und p‐Diaminen (1969)

Abstract Die Titelverbindung bildet mit primären und sekundären aromatischen Monoaminen und p ‐Diaminen die vinylogen Amide und Bis‐amide 1 – 5 . Dimethylanilin wird in p ‐Stellung elektrophil substituiert ( 6 ). Phenylcyclobutendion liefert mit Dimethylanilin unter 1.4‐Addition das Arylierungsprodukt 7 .
CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients (2012)

CXC chemokine receptor 7 expression predicts poor disease-free and disease-specific survival in cervical cancer patients, and might be a promising new therapeutic marker. In a large majority of cases, CXCR7 is co-expressed with CXCR4 and/or EGFR, supporting the hypothesis that these receptors assist in CXCR7 signal transduction.
Wave Run-Up and Sea-Cliff Erosion (1995)

Studies have been undertaken along the Oregon coast to better understand the processes involved in sea cliff erosion in order to develop improved predictions of the susceptibilities of properties to wave attack. A model has been developed that includes evaluations of extreme water elevations measured by tide gauges, calculations of wave run-up levels due to major storms, and a documentation of beach morphology variations that affect the wave run-up and determine the elevation of the junction between the beach and toe of the sea cliff. The occurrence of erosion depends on the combined water levels compared with the beach/cliff junction. All of these factors vary with time and also spatially along the coast. A program has been initiated to measure wave run-up on Oregon beaches ranging from reflective to dissipative in order to test the model predictions.
Integrated Geoscience Study Extends the Life of a Major Mature Asset: Onshore PZ, Kuwait, Saudi Arabia (2020)

Summary The mature onshore Partitioned Zone (PZ) between Kuwait and Saudi Arabia covers an area of 5,512 km2 and contains five major oil fields. A key question often asked is whether there is additional exploitable hydrocarbon resources in the PZ that could extend the life of this major asset. Kuwait Gulf Oil Company (KGOC) recently acquired and processed a new high-resolution 3D seismic survey covering the entire PZ. This and all other available geoscientific and well data were interpreted and analysed to identify, risk and rank new exploration prospects/leads throughout the entire stratigraphic column. A detailed multi-disciplinary integrated geoscience study was undertaken for all proven and potential reservoir layers. This led to the build of a high-resolution, multi-layered 3D petroleum systems model (3DPSM) focusing on the complex interactions of multiple source rocks, migration pathways and proven and probable producing horizons. A number of prospects/leads, are described in detail and incorporated into a ranked Exploration Portfolio. This portfolio includes prospects/leads for both potential oil and gas bearing reservoirs contained within both structural closures and stratigraphic pinch-outs. Ultimately, this new Exploration Portfolio will extend the hydrocarbon potential of the PZ through until the mid. 21st century.
Fast and Accurate Frequency Estimation Using Sliding DFT (2012)

Frequency Estimation of a complex exponential is a problem relevant to a large number of fields. In this paper a computationally efficient and accurate frequency estimator is presented using the guaranteed stable Sliding DFT which gives stability as well as computational efficiency. The estimator approaches Jacobsen's estimator and Candan's estimator for large N with an extra correction term multiplied to it for the stabilization of the sliding DFT. Simulation results show that the performance of the proposed estimator were found to be better than Jacobsen's estimator and Candan's estimator.
Issues with ethernet parametric testing in a production enviroment (2009)

Ethernet is an emerging communication technology in the avionics industry. There are many advantages to utilizing Ethernet that include a very high data rate, some noise immunity, weight savings, and commercially available equipment. Some of the disadvantages include extra line replaceable units (LRUs) on the plane (Ethernet switches) and added difficulties in aircraft wiring. This new technology brings with it many challenges in an automated test equipment (ATE) environment including, signal distortion, connector repeatability, and expensive measurement equipment. Rockwell Collins' traditional ATEs utilize a switch system to simulate the avionics environment for LRU testing which limits the quantity of I/O stimulus required. This switch system was not designed to support 100Base-TX Ethernet switching for parametric testing. A new switch system, interface panel, and an updated oscilloscope had to be designed into the ATE. Signal distortion: There were two main issues realized after integration: impedance mismatches due to different cables and connectors and excess loss which needed to be quantified. These issues made it very difficult to make repeatable and accurate measurements on the waveform. Connector repeatability: The Ethernet connector available on the commercial market is the RJ4S. This connector is very unreliable and wears out easily in a production/field environment due to the need for a reconfigurable ATE that can be capable of testing multiple test products with multiple test adapter cables. Expensive equipment: The required parametric tests (physical layer) for 100Base-TX Ethernet at the reference plane (LRU shipside connector) per ARLNC 664 are as follows: Differential Signal, UTP, zero-peak Signal Amplitude Symmetry (positive/negative) Rise and Fall Time (10% and 90% levels) Rise and Fall Time Symmetry Duty Cycle Distortion, peak-to-peak Transmit Jitter (HLS) Overshoot. The test equipment required for these Ethernet measurements adds extra cost to the ATE that was traditionally not required. This new scope adds multiple issues with repeatability, accurate measurements, and integration issues within an ATE environment while attempting to maintain backwards compatibility. This presentation will review Rockwell Collins' experience in implementing Ethernet parametrics in a production environment, the pros and cons, and screen shots of the Ethernet waveforms before and after being switched through the ATE.
Imaging Supramolecular Morphogenesis with Confocal Laser Scanning Microscopy at Elevated Temperatures (2020)

The morphogenesis of supramolecular assemblies is a highly dynamic process that has only recently been recognized, and our understanding of this phenomenon will require imaging techniques capable of crossing scales. Shape transformations depend both on the complex energy landscapes of supramolecular systems and the kinetically controlled pathways that define their structures and functions. We report here the use of confocal laser scanning microscopy coupled with a custom-designed variable-temperature sample stage that enables <i>in situ</i> observation of such shape changes. The submicrometer resolution of this technique allows for real-time observation of the nanostructures in the native liquid environments in which they transform with thermal energy. We use this technique to study the temperature-dependent morphogenic behavior of peptide amphiphile nanofibers and photocatalytic chromophore amphiphile nanoribbons. The variable-temperature confocal microscopy technique demonstrated in this work can sample a large volume and provides real-time information on thermally induced morphological changes in the solution.
“Inherently Chiral” Ionic‐Liquid Media: Effective Chiral Electroanalysis on Achiral Electrodes (2017)

To achieve enantioselective electroanalysis either chiral electrodes or chiral media are needed. High enantiodiscrimination properties can be granted by the "inherent chirality" strategy of developing molecular materials in which the stereogenic element responsible for chirality coincides with the molecular portion responsible for their specific properties, an approach recently yielding outstanding performances as electrode surfaces. Inherently chiral ionic liquids (ICILs) have now been prepared starting from atropisomeric 3,3'-bicollidine, synthesized from inexpensive reagents, resolved into antipodes without need of chiral HPLC and converted into long-chain dialkyl salts with melting points below room temperature. Both the new ICILs and shorter family terms, solid at room temperature, employed as low-concentration additives in achiral ILs, afford impressive enantioselection for the enantiomers of different probes on achiral electrodes, regularly increasing with additive concentration.
Newton-raphson based efficient model predictive control applied on active vibrating structures (2009)

This article presents a computationally efficient model predictive algorithm, applied on an actively controlled vibrating structure. A brief introduction on the experimental device and theoretical background is followed by an analysis of the practical properties, drawbacks and performance of the controller in question. The experimental data presented and interpreted here shows, that the Newton-Raphson based predictive algorithm presents a viable approach to the control of fast sampling systems.
1986 Ward Burdick Award Lecture: Pathology as an Investigative Discipline (1987)

1986 Ward Burdick Award Lecture: Pathology as an Investigative Discipline Get access E. Eric Muirhead, M.D. E. Eric Muirhead, M.D. Departments of Pathology, Baptist Memorial Hospital and the University of Tennessee, College of Medicine, Memphis, Tennessee Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 87, Issue 4, 1 April 1987, Pages 543–553, https://doi.org/10.1093/ajcp/87.4.543 Published: 01 April 1987 Article history Received: 08 October 1986 Accepted: 08 October 1986 Published: 01 April 1987
Bacillus thuringiensisisolates from Egyptian soils and their potential activity against lepidopterous insects (2012)

This study aims to search for indigenous Bacillus thuringiensis (Bt) strains from the soils of different locations representing 11 Egyptian governorates. A total of 2671 colonies from 93 soil samples were examined. The total number of Bt positive soil samples was 40/93 i.e. 43.01%. The results indicate that the percentage of the occurrence of Bt in these samples was 3.818%. The Egyptian soil showed to be rich in Bt. The evaluation of the potential activity of 40 positive soil isolates against Spodoptera littoralis and Helicoverpa (=Heliothis) armigera was carried out. Subsequently, LC50 and LC90 values and the potency of the Bt isolates were determined when applied against the target insects with reference to three standard preparations.
Design and optimization of a differentially coded variable block size motion compensation system (2002)

While motion fields estimated by maximizing the temporal prediction quality tend to be noisy and demand a large number of bits to encode, finding the motion vectors (MVs) that allow efficient representations requires explicitly considering rate and distortion simultaneously. However, the application of rate-distortion optimization to current variable block size motion compensation (MC) systems is hampered by the fact that MV dependency introduced by the differential coding stage, e.g., the medium differential coding in the advanced prediction mode of the ITU-T standard H.263, makes the rate-distortion (R-D) optimization process extremely difficult. We propose two 1-D differential MV coding frameworks for variable block size MC systems. We show that for one of the proposed differential coding structures the optimal block sizes and the MVs can be jointly obtained by applying dynamic programming (DP) and tree-pruning techniques hierarchically without enumerating all combinations, while a near-optimal solution can be obtained for the other one by adopting a similar optimization procedure with little modification. By comparing the performance of our R-D encoding scheme with that of the H.263 test model TMN5, we find that our approaches achieve 30-60% bit-rate reductions in coding motion vectors, which results in greater than 1 dB gains within a MC hybrid coding environment for most head-and-shoulder videophone sequences under a low-bit-rate constraint.
Some observations on the performance of CCN-Flooding (2014)

We focus on one of the earliest forwarding strategies proposed for Content-Centric Networks (CCN), namely the CCN-Flooding approach to populate the Forwarding Information Bases (FIB) and forward packets. Pure CCN-Flooding in its own right is a potentially viable, though highly deprecated, option to forward packets. But CCN-Flooding is also proposed as an integral component of alternative forwarding strategies. Thus, it cannot entirely be dismissed, and its behavior merits study. We examine the CCN-Flooding approach using a combination of several topologies and workload sets with differing characteristics. In addition to topological effects, we identify various issues that arise, such as: the difficulty of calibrating Pending Interest Table (PIT) timeouts; a PIT-induced isolation effect that negatively impacts bandwidth consumption and system response time; and the effects of adopting or not adopting FIB routes based on volatile in-network cache entries. In conclusion, we briefly compare CCN-Flooding vs. CCN-Publication when the overhead bandwidth costs of pre-populating FIBs in the latter are also taken into account.
Variation in the Geometric Interpretation of the Eigenvalue Problem of a Structure Due to Damage (1999)

Abstract This paper studies the behavior of the geometric interpretation of the eigenvalue problem. An arbitrary two degree of freedom structure is modeled as a two mass, two spring system. The damage in the system is represented as a reduction in stiffness and the structure is assumed to be a natural conservative system. The geometric interpretation of the system is an ellipse which is examined under various damage conditions occurring on the structure. It is shown that this representation is a convex set and that damage produces a new set which is the convex hull of the existing condition. These results are graphed for several damage scenarios of the system.
Bandwidth-Scalable Long-Haul Transmission Using Synchronized Colorless Transceivers and Efficient Wavelength-Selective Switches (2012)

We propose a modular scalable long-haul architecture supporting variable-bandwidth channels with bit rates from 100 Gbit/s to beyond 1 Tbit/s. Colorless transceivers have two operating modes. One transceiver can transmit/receive a conventional narrow-band channel occupying a 30-GHz bandwidth and conveying 100 Gbit/s, or a set of M transceivers can cooperate to transmit/receive a wideband channel occupying an M 50-GHz bandwidth and conveying roughly 160 Gbit/s per 50 GHz (assuming polarization-multiplexed quaternary phase-shift keying). A colorless wavelength-selective switch supports two modes of add/drop (or (de)multiplexing) operation. It can add/drop narrow-band channels (each from/to one port) with minimal loss, or can add/drop wideband channels (each from/to M ports) without spectral gaps, with an additional loss not exceeding 1/3 (-4.8 dB), independent of M. Transceivers can use either single-carrier modulation or orthogonal frequency-division multiplexing (OFDM). We analyze and simulate OFDM-based systems to determine key design requirements, especially for synchronization of cooperating transceivers. A representative design achieves 1520-km reach with 1.4-dB margin in a dispersion-managed network using only erbium-doped fiber amplifiers, improving average spectral efficiency from about 2 to nearly 3 bits/s/Hz.