gebhart/patrepeval huggingface dataset:
Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets (2004)

MEPE (Matrix Extracellular PhosphoglycoprotEin) expression is markedly elevated in X-linked-hypophosphatemic-rickets (HYP) and tumor-induced osteomalacia (TIO). In normal individuals, circulating serum-levels of MEPE are tightly correlated with serum-phosphorus, parathyroid hormone (PTH) and bone mineral density (BMD). Also, MEPE derived, C-terminal ASARM-peptides are candidate minhibins and/or phosphatonins. Our aims were to determine: 1. whether MEPE-ASARM-peptide(s) are abnormally elevated in HYP/hyp serum, and, 2. whether the ASARM-peptide(s) accumulate in hyp mice kidney renal-tubules. Using a specific competitive ELISA we measured a five fold increase (P=0.007) of serum ASARM-peptide(s) in human HYP patients (normal subjects 3.25 microM n=9; S.E.M.=0.51 and HYP-patients 15.74 microM, n=9; S.E.M.=3.32). A 6.23 fold increase (P=0.008) was measured in hyp male mice compared with their normal male siblings (normal-siblings, 3.73 muM, S.E.M.=0.57, n=3; and hyp-mice 23.4 microM, n=3, S.E.M.=4.01). Renal immuno-histological screening also revealed a dramatic increase of ASARM-peptides in regions anatomically consistent with the proximal convoluted tubules. This study demonstrates for the first time that markedly elevated serum levels of protease-resistant ASARM-peptide(s) occur in HYP/hyp and they accumulate in murine hyp kidneys. These peptides are thus likely responsible for the phosphaturia and defective mineralization in HYP/hyp and TIO.
Angiotensin II Receptor Heterogeneity (1991)

The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents. One of our earliest indications was the frequent observation of incomplete inhibition of the binding of AII to adrenal cortical membranes. Autoradiographic studies demonstrated that all of the labeling of the rat adrenal was blocked by unlabeled AII or saralasin, but not by DuP 753. The predominant receptor in the rat adrenal cortex (80%) is sensitive to dithiothreitol (DTT) and DuP 753, and is designated AII-1. The residual sites in the adrenal cortex and almost all of the sites in the rat adrenal medulla are insensitive to both DTT and DuP 753, but were blocked by EXP655. These sites have been confirmed by ligand binding studies and are designated AII-2. The rabbit adrenal cortex is unique in yielding a nonuniform distribution of AII-2 sites around the outer layer of glomerulosa cells. In the rabbit kidney, the sites on the glomeruli are AII-1, but the sites on the kidney capsule are AII-2. Angiotensin III appears to have a higher affinity for AII-2 sites since it inhibits the binding to the rabbit kidney capsule but not the glomeruli. Elucidation of the distribution and function of these diverse sites should permit the development of more selective and specific therapeutic strategies.
San Diego County Water Authority’s Rapid Response to Thrust Restraint Issues in the Second Aqueduct at Moosa Canyon (2021)

The San Diego County Water Authority’s Second Aqueduct, which comprises Pipeline 3 (72 in. diameter welded steel pipe), Pipeline 4 (90 in. diameter PCCP), and Pipeline 5 (96 in. diameter PCCP), makes a 20° horizontal bend at Moosa Creek at the bottom of the Moosa Canyon, where the creek has changed course over the years, and soil has been eroded, resulting in reduced soil cover and variable soil stiffness along the thrust restraint zone of the three pipelines. Despite the relatively mild bend angle, high internal pressures at this location increases the importance of adequate thrust restraint. In fall 2019, a leakage in the first PCCP segment adjacent to the bend in Pipeline 4 prompted an emergency declaration by the Water Authority and subsequent condition assessment and emergency carbon fiber reinforced polymer (CFRP) strengthening of the bend and several adjacent PCCP segments. Shortly thereafter, similar inspections and analyses were performed on the adjacent Pipelines 3 and 5, which indicated inadequacy of thrust restraint in Pipeline 5 as well and resulted in similar CFRP strengthening. This paper presents the Water Authority’s response with support from its consultant for these projects and some key takeaways from the Water Authority’s perspective.
<title>Software framework for scanning cytometry</title> (2000)

This paper introduces a new object-oriented software framework suitable for scanning image cytometry application development. The goal of scanning image cytometry is the development of an instrument that locates and measures every cell on a microscope slide at high speed without requiring operator interaction. This capability extends traditional quantitative techniques, such as flow cytometry, through the availability of image data that can provide similar intensity measurement as well as detailed image morphometry and population geometry. Domain concepts are identified, abstracted and categorized into three thematic families: (1) physical cytometer hardware components, (2) image and image- derived measurement data, and (3) runtime dynamic and extendible image processing components. Additional abstractions are provided for the image table, an embedded database for disk archival and general access to metaimage areas-of-interest, and for the cytometer, which manages physical hardware abstractions and organizes their collaboration into high-level scanning operations. Detailed examples of framework mechanisms are given to illustrate use.
Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmune glaucoma. (2013)

Our findings suggest that these modified antibodies play a substantial role in mechanisms leading to RGC death. The slow dissolution of RGCs observed in animals with autoimmune glaucoma is comparable to the slow progressive RGC loss in glaucoma patients, thus making this a useful model to develop neuroprotective therapies in the future.
Regrasp Planning Considering Bipedal Stability Constraints (2018)

This paper presents a Center of Mass (CoM) based manipulation and regrasp planner that implements stability constraints to preserve the robot balance. The planner provides a graph of IK-feasible, collision-free and stable motion sequences, constructed using an energy based motion planning algorithm. It assures that the assembly motions are stable and prevent the robot from falling while performing dexterous tasks in different situations. Furthermore, the constraints are also used to perform an RRT-inspired task-related stability estimation in several simulations. The estimation can be used to select between single-arm and dual-arm regrasping configurations to achieve more stability and robustness for a given manipulation task. To validate the planner and the task-related stability estimations, several tests are performed in simulations and real-world experiments involving the HRP5P humanoid robot, the 5th generation of the HRP robot family. The experiment results suggest that the planner and the task-related stability estimation provide robust behavior for the humanoid robot while performing regrasp tasks.
Acute Suprarenal Aortogastric Fistulae Caused by Gunshot Wounds (1996)

Penetrating suprarenal aortic injuries carry high mortality rates. Difficulties in surgical exposure and bleeding control in this area add to the ominous prognosis. In rare occasions, synchronous injury to the adjacent upper part of stomach may lead to an acute aortogastric fistula, resulting in aortic bleeding into the stomach instead of the peritoneal cavity. Filling of the stomach with blood may temporarily tamponade the aortic perforation. Distortion of this delicate communication during dissection before proximal and distal vascular control is achieved could result in catastrophic hemorrhage. Therefore, recognition of the importance of a fully distended stomach at the suspicion of aortic injury is essential in directing a particular surgical strategy that aims to achieve an unrestricted operative exposure and successful bleeding control.
Antibacterial Properties of Tetraalkylammonium and Imidazolium Tetraalkoxycalix[4]arene Derivatives (2015)

The antibacterial and antibiofilm activities of several amphiphillic tetracationic calixarenes with different functional groups were evaluated. Our results demonstrate the clear dependence of antibacterial activity from the alkyl chain length on the lower rim of calixarene. Tetrapropoxycalixarenes have 10-50 times higher antibacterial activity than tetraoctyl calixarenes with same cationic residues on the upper rim. At the same time, one of the tetrapropoxycalixarenes shows high inhibitory activity against Staphylococcus aureus biofilms. Therefore, the alkyl chain length is an important characteristic that can be used for further antibacterial agent design. Keywords: Antibacterial, biofilm, calixarene, QAS, structure-activity relationship.
Combined CFD - Experimental Analysis of the In-Cylinder Combustion Phenomena in a Dual Fuel Optical Compression Ignition Engine (2021)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Methane supply in diesel engines operating in dual fuel mode has demonstrated to be effective for the reduction of particulate matter and nitric oxides emissions from this type of engine. In particular, methane is injected into the intake manifold to form a premixed charge with air, while a reduced amount of diesel oil is still directly injected to ignite the mixture inside the cylinder. As a matter of fact, the liquid fuel burns following the usual diffusive combustion, so activating the gaseous fuel oxidation in a premixed flame. Clearly, the whole combustion process appears to be more complex to be described in a CFD simulation, mainly because it is not always possible to select in the 3-dimensional codes a different combustion model for each fuel and, also, because other issues arise from the interaction of the two fuels. In this work, the Autoignition-Induced Flame Propagation model, which is included in the ANSYS Forte® tool, is applied since it represents the most appropriate model to describe the dual fuel combustion. Indeed, this model uses the G-equation to track the position and the propagation of the premixed turbulent flame, but the flame activation source is represented by the autoignition kinetics reaction scheme for the n-dodecane. The results discussed in this paper refer to experimental tests carried out on an optically accessible research engine whose real geometry and mesh were reproduced with the K3PREPW tool. Through the use of a system of sensors and optical diagnostic, the combined numerical - experimental study allows a deeper investigation of phenomena that take place in real dual fuel operations characterized by different engine speeds, 1500 and 2000 rpm, load levels, 2 and 5 bar of BMEP, injection timing and a premixed ratio between 86 and 89%.&lt;/div&gt;&lt;/div&gt;
Biologically Inspired Behavioral Strategies for Autonomous (2003)

The natural world is a rich source of problem- solving approaches. This paper discusses the feasibility and technical challenges underlying mimicking, or analogously adapting, biological behavioral strategies to missiodflight planning for aerial vehicles engaged in planetary exploration. Two candidate concepts based on natural resource utilization and searching behaviors are adapted to technological applications. Prototypes and test missions addressing the difficulties of implementation and their solutions are also described.
High-performance AlGaN∕GaN lateral field-effect rectifiers compatible with high electron mobility transistors (2008)

A high electron mobility transistor (HEMT)-compatible power lateral field-effect rectifier (L-FER) with low turn-on voltage is demonstrated using the same fabrication process as that for normally off AlGaN∕GaN HEMT, providing a low-cost solution for GaN power integrated circuits. The power rectifier features a Schottky-gate-controlled two-dimensional electron gas channel between the cathode and anode. By tying up the Schottky gate and anode together, the forward turn-on voltage of the rectifier is determined by the threshold voltage of the channel instead of the Schottky barrier. The L-FER with a drift length of 10μm features a forward turn-on voltage of 0.63V at a current density of 100A∕cm2. This device also exhibits a reverse breakdown voltage (BV) of 390V at a current level of 1mA∕mm and a specific on resistance (RON,sp) of 1.4mΩcm2, yielding a figure of merit (BV2∕RON,sp) of 108MW∕cm2. The excellent device performance, coupled with the lateral device structure and process compatibility with AlGaN∕GaN HEMT, make the proposed L-FER a promising candidate for GaN power integrated circuits.
Survival in the Presence of Antifungals (2007)

How yeast cells respond to cell wall stress is relatively well understood; however, how filamentous fungi cope with cell wall damage is largely unexplored. Here we report the first transcriptome analysis of Aspergillus niger exposed to the antifungal compounds caspofungin, an inhibitor of beta-1,3-glucan synthesis, and fenpropimorph, which inhibits ergosterol synthesis. The presence of sublethal drug concentrations allowed A. niger to adapt to the stress conditions and to continue growth by the establishment of new polarity axes and formation of new germ tubes. By comparing the expression profile between caspofungin-exposed and nonexposed A. niger germlings, we identified a total of 172 responsive genes out of 14,509 open reading frames present on the Affymetrix microarray chips. Among 165 up-regulated genes, mainly genes predicted to function in (i) cell wall assembly and remodeling, (ii) cytoskeletal organization, (iii) signaling, and (iv) oxidative stress response were affected. Fenpropimorph modulated expression of 43 genes, of which 41 showed enhanced expression. Here, genes predicted to function in (i) membrane reconstruction, (ii) lipid signaling, (iii) cell wall remodeling, and (iv) oxidative stress response were identified. Northern analyses of selected genes were used to confirm the microarray analyses. The results further show that expression of the agsA gene encoding an alpha-1,3-glucan synthase is up-regulated by both compounds. Using two PagsA-GFP reporter strains of A. niger and subjecting them to 16 different antifungal compounds, including caspofungin and fenpropimorph, we could show that agsA is specifically activated by compounds interfering directly or indirectly with cell wall biosynthesis.
Miniaturisation de fonctions optiques en technologie intégrée polymère: exemple des micro-résonateurs (2004)

session orale 1 " Matériaux et Composants Photoniques pour les Transmissions Optiques I " [Je1.4]
Other Classes of Eukaryotic Glycans (2015)

This chapter focuses on several less easily categorized types of glycoprotein linkages that occur on specific proteins or domains, most of which have specific biological functions. O-linked modifications of epidermal growth factor (EGF)-like repeats (O-fucose, O-glucose, and O-GlcNAc) regulate the Notch signaling pathway. O-Fucosylation of thrombospondin type 1 repeats (TSRs) is required for folding of these domains in a number of secreted matricellular proteins. O-Mannosylation of α-dystroglycan is essential for interactions with several extracellular matrix proteins. Defects in the glycosyltransferases that add these glycans (O-fucose, O-glucose, O-GlcNAc, and O-mannose) result in human diseases. C-Mannosylation is a unique form of glycosylation in which mannose is linked through a carbon–carbon bond to tryptophan. O-Linked galactose disaccharides are added to hydroxyproline and hydroxylysine residues and play an important role in collagen fibril formation. Although the glycans described here are found on relatively few glycoproteins, they play specific and important roles in biology.
TYRAMINE ANTAGONISTIC PROPERTIES OF AGN 1135, AN IRREVERSIBLE INHIBITOR OF MONOAMINE OXIDASE TYPE B (1981)

1 The effects of the irreversible monoamine oxidase (MAO) inhibitors, AGN 1133, AGN 1135 and (-)-deprenyl, on tyramine and noradrenaline responses and uptake of [3H]-metaraminol were investigated in the isolated vas deferens of the rat. Uptake of [3H]-metaraminol and [3H]-octopamine was compared in mouse vas deferens. The modification of tyramine and noradrenaline-induced pressor responses by AGN 1133 and AGN 1135 was examined in anaesthetized rats and cats. 2 AGN 1133 (7.5 x 10(-6)M) greatly potentiated responses to tyramine in the rat isolated vas deferens. Both AGN 1135 and (-)-deprenyl inhibited tyramine responses selectively at concentrations above 10(-5)M (which caused almost complete inhibition of MAO types A and B) but tyramine responses were potentiated on washing out the inhibitors. 3 AGN 1135 (10(-4)M) and (-)-deprenyl (10-5)M) inhibited [3H]-metaraminol uptake by about 20% in rat and mouse vas deferens; neither inhibitor affected [3H]-octopamine uptake in mouse vas deferens. Desmethylimipramine (10(-6)M) inhibited amine uptake by more than 70%. 4 AGN 1133 (1.5 mg/kg) potentiated pressor responses to tyramine in rats and cats whereas AGN 1135 (1.5 mg/kg) did not. 5 AGN 1135 possesses tyramine antagonistic activity which is qualitatively similar to that of (-)-deprenyl but which cannot satisfactorily be explained by inhibition of neuronal or granula amine uptake.
Fast pH-mediated changes of the viscosity of protein solutions studied with a voltage-modulated quartz crystal microbalance (2020)

An electrochemical quartz crystal microbalance is described, which achieves a time resolution down to 100 μs. Accumulation and averaging over a few hours bring the noise down to about 30 mHz. The application examples are pH-driven viscosity changes in albumin solutions. The pH was switched with the electrode potential. The characteristic response time is in the millisecond range. The focus is on experimental aspects as well as advantages and limitations of the technique.
Mini-Disk Capillary Array Coupling with LAMP for Visual Detection of Multiple Nucleic Acids using Genetically Modified Organism Analysis as an Example (2019)

Convenient, portable, and low-cost multiplex nucleic acid testing (NAT) systems are the trends in the fields of food safety, environmental microorganisms, molecular diagnosis, etc. In this study, we developed a novel system for visual monitoring of multiple nucleic acids combining a mini-disk capillary array (diameter = 17 mm, embedded with 6-10 capillaries), visual loop-mediated isothermal amplification (LAMP), and quick DNA extraction called mDC-LAMP. The performance and applicability of mDC-LAMP in testing multiple nucleic acids were evaluated and verified employing genetically modified contents analysis as an example. All of the results confirmed that mDC-LAMP has the advantages of high specificity without any cross contamination, high sensitivity with a limit of detection of 25 copies/reaction, high throughput with flexible channel sensors, easy fabrication, and low costs. We believe that mDC-LAMP is a competitive choice for on-spot monitoring of multiple nucleic acids in terms of the easy fabrication/operation, low costs, and suitable performance presented in the nucleic acids test.
Rearrangement of N-(p-Toluenesulfonyloxy)-2-pyrrolidinone (1987)

e provides 3-(p-toluenesulfony1oxy)-2-pyrrolidinone by an apparent n i t r o g e n analog of t h e F a v o r s k i i rearrangement.
Local immunity of the respiratory mucosal system in chickens and turkeys (2011)

This review article presents fundamental mechanisms of the local mucosal immunity in selected regions of the respiratory tract in healthy birds and in some pathological conditions. The respiratory system, whose mucosa come into direct contact with microorganisms contaminating inhaled air, has some associated structures, such as Harderian gland (HG), conjunctive-associated lymphoid tissue (CALT) and paranasal glands (PG), whose participation in local mechanisms of the mucosal immunity has been corroborated by numerous scientific studies. The nasal mucosa, with structured clusters of lymphoid tissue (NALT - nasal-associated lymphoid tissue) is the first to come into contact with microorganisms which contaminate inhaled air. Lymphoid nodules, made up of B cells with frequently developed germinal centres (GC), surrounded by a coat of CD4+ cells, are the major NALT structures in chickens, whereas CD8+ cells are situated in the epithelium and in the lamina propria of the nasal cavity mucosa. Studies into respiratory system infections (e.g. Mycoplasma gallisepticum) have shown the reactivity of the tracheal mucosa to infection, despite a lack of essential lymphoid tissue. Bronchus-associated lymphoid tissue (BALT) takes part in bronchial immune processes and its structure, topography and ability to perform defensive function in birds is largely age-dependent. Mature BALT is covered by a delicate layer of epithelial cells, called follicle-associated epithelium (FAE). Germinal centres (GC), surrounded by CD4+ cells are developed in most mature BALT nodules, while CD8+ lymphocytes are dispersed among lymphoid nodules and in the epithelium, and they are rarely present in GC. Macrophages make up the first line of defence mechanisms through which the host rapidly responds to microorganisms and their products in the respiratory mucosal system. Another very important element are polymorphonuclear cells, with heterophils being the most important of them. Phagocytic cells obtained from lung lavages in birds are referred to as FARM (free avian respiratory macrophages). Their number in chickens and turkeys is estimated to be 20 times lower than that in mice and rats, which indicates a deficit in the first-line of defence in the birds' respiratory system. There are numerous B cells and antibody secreting cells (ASC) present throughout the respiratory system in birds. Their role comes down to perform antigen-specific protection by producing antibodies (IgM, IgY or IgA class) as a result of contact with pathogenic factors.
Integrated Buck-Flyback Converter as a High-Power-Factor Off-Line Power Supply (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper investigates the integrated buck-flyback converter (IBFC) as a good solution for implementing low-cost high-power-factor ac–dc converters with fast output regulation. It will be shown that, when both buck and flyback semistages are operated in discontinuous conduction mode, the voltage across the bulk capacitor, which is used to store energy at low frequency, is independent of the output power. This makes it possible to maintain the bulk capacitor voltage at a low value within the whole line voltage range. The off-line operating modes of the IBFC are also investigated to demonstrate that the control switch of the proposed converter handles lower root-mean-square currents than those in similar integrated converters. The off-line operation of the IBFC is analyzed to obtain the design characteristics of the bulk capacitor voltage. Finally, the design and experimental results of a universal input 48 V-output 100 W ac–dc converter operating at 100 kHz is presented. Experiments show that the IEC-61000-3-2 input current harmonic limits are well satisfied and efficiency can be as high as 82%. </para>
Adaptive loss minimization control of inverter-fed IPM motor drives (2002)

An adaptive loss minimization control strategy is presented for inverter-fed interior permanent magnet (IPM) motor drives. The loss minimization process is very fast and the drive performance under the control is very smooth. The control system is implemented using a TMS320C31 DSP. Excellent experimental results confirm the validity of the proposed strategy.
Analytic model of rotational wave packet excitation with arbitrary pump polarization in the impulsive limit (2007)

An analytic model for non-resonant rotational wave packet excitation in linear molecules by intense ultrafast elliptically polarized laser pulses in the impulsive limit is presented