gebhart/patrepeval huggingface dataset:
Oxo Ligand Reactivity and Bonding in the Dinuclear W−Re Oxo−Acetylide Complex (η5-C5Me5)W(O)Re(CO)4(μ-H)(CCPh) (1996)

The trinuclear oxo−acetylide metal cluster (η5-C5Me5)W(O)Re2(CO)8(μ-CCPh) (1) reacts with thiophenol in refluxing toluene to afford the dinuclear metal complex (η5-C5Me5)W(O)Re(CO)4(μ-H)(μ-CCPh) (2) in 90% yield. Upon treatment with Me3NO in acetonitrile, complex 2 loses one CO ligand and is converted initially to an acetonitrile derivative, (η5-C5Me5)W(O)Re(CO)3(NCMe)(μ-H)(μ-CCPh) (4), and then to a head-to-tail dimer, [(η5-C5Me5)WRe(CO)3(μ-O)(μ-H)(μ-CCPh)]2 (5), through the formation of two W⋮O−Re bridges. Extended Hückel MO calculations indicate that the most likely site of electrophilic attack is the oxo oxygen atom, and in agreement with this prediction, protonation of 2 with CF3CO2H is suggested to give the unstable hydroxy complex 6.
Species specificity in the activation of Xer recombination at dif by FtsK (2003)

In Escherichia coli, chromosome dimers are resolved to monomers by the addition of a single cross-over at a specific locus on the chromosome, dif. Recombination is performed by two tyrosine recombinases, XerC and XerD, and requires the action of an additional protein, FtsK. We show that Haemophilus influenzae FtsK activates recombination by H. influenzae XerCD at H. influenzae dif. However, it cannot activate recombination by E. coli XerCD. Reciprocally, E. coli FtsK cannot activate recombination by the H. influenzae recombinases at H. influenzae dif. We took advantage of this species specificity to gain further insight into the mechanism of activation of Xer recombination at dif by FtsK. We mapped the region of FtsK implicated in species specificity to the extreme 140-amino-acid C-terminal residues of the protein. Our results suggest that FtsK interacts directly with XerCD in order to activate recombination at dif.
Visual input dynamically changes responses to spatiotemporal tactile input patterns in S1 neurons (2022)

Abstract To understand how sensory events are represented in and perceived by the brain, one must understand how varying internal brain states affect neuronal decoding of sensory input. Recent studies indicate global state changes in the brain impact the representation of haptic events in neurons of the primary somatosensory cortex (S1). It could be argued that the manipulations used so far to alter the cortical circuitry behavior were artificial and not reflective of normal information processing in the neocortex. In the present study we therefore wanted to explore if natural visual stimulation also could impact the interpretation of given tactile input patterns. We recorded the unitary extracellular responses to a set of spatiotemporal tactile input patterns presented either alone or together with simultaneously multicolor flashing lights from a large number of neurons in parallel in the rat primary somatosensory cortex (S1). We found that the visual input, mildly but consistently altered the temporal spike outputs to tactile input patterns in S1 neurons. We argue that the visual input change the global cortical state to an extent that it affects the cortical representation of haptic events even within the S1 and that this is an indication that the cortical network in its information processing may be far more reliant on globally distributed network dynamics than traditionally thought.
The in vivo and in vitro effects of kisspeptin on human ovarian function (2018)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Intermartensitic transitions in Ni–Mn–Fe–Cu–Ga Heusler alloys (2008)

A series of Fe doped Ni2Mn0.75-xFexCu 0.25Ga Heusler alloys have been investigated by means of x-ray diffraction, magnetizations, thermal expansion, and electrical resistivity measurements. In Ni2Mn0.75Cu0.25Ga, martensitic and ferromagnetic transitions occur at the same temperature. Partial substitution of Mn by Fe results in a decrease of the martensitic transition temperature, TM, and an increase of the ferromagnetic transition temperature, TC, resulting in separation of the two transitions. In addition to the martensitic transition, complete thermoelastic intermartensitic transformations have been observed in the Fe doped Ni2Mn 0.75-xFexCu0.25Ga samples with x>0.04. An unusual transition is observed in the alloy with x = 0.04. The magnetization curve as a function of increasing temperature shows only one first-order transition in the temperature range 5-400K, which is identified as a typical coupled magnetostructural martensitic transformation. The magnetization curve as a function of decreasing temperature shows three different transitions, which are characterized as the ferromagnetic transition, the martensitic transition and the intermartensitic transition. © 2008 IOP Publishing Ltd.
Red Queen Dynamics, Competition and Critical Points in a Model of RNA Virus Quasispecies (1999)

this paper we present a simple model which allows previous hypothesis to be tested and provides an interpretation for the observed experimental results
Audio-visual robot command recognition (2012)

This paper addresses the problem of audio-visual command recognition in the framework of the D-META Grand Challenge1. Temporal and non-temporal learning models are trained on visual and auditory descriptors. In order to set a proper baseline, the methods are tested on the "Robot Gestures" scenario of the publicly available RAVEL data set, following the leave-one-out cross-validation strategy. The classification-level audio-visual fusion strategy allows for compensating the errors of the unimodal (audio or vision) classifiers. The obtained results (an average audio-visual recognition rate of almost 80%) encourage us to investigate on how to further develop and improve the methodology described in this paper.
Work in progress: radionuclide imaging of indium-111-labeled eosinophils in mice. (1983)

Eosinophils isolated from peritoneal exudates were labeled with indium-111-oxine and injected intravenously into sensitized mice. They became localized at sites of inflammation produced by intradermal injections of schistosomal antigen or Toxocara canis larvae, whereas labeled neutrophils did not. Intense uptake of eosinophils by normal spleen, liver, and bone marrow was noted, with tracer distribution effectively complete by 5 hours after injection. Indium-111-eosinophil studies appear to be quite sensitive to parasitic inflammatory reactions; in contrast, nonspecific inflammation such as that induced by turpentine causes localization of eosinophils, but to a lesser extent. This technique may be useful in the study of parasitic and allergic disease.
Meta-Substituted Thienyl Benzenes: A Comparative Synthetic, Structural and Computational Study (2008)

A selection of metal-catalyzed C-C bond-forming strategies has been evaluated in the synthesis of a series of meta-substituted thienylbenzenes, (T(n))(2)C(6)H(4) and (T(n))(3)C(6)H(3) (n = 1, 2; T(1) = 2-thienyl; T(2) = 2,2'-bithien-5-yl). Kumada coupling reactions catalyzed by PdCl(2)(dppf) between the appropriate thienyl Grignard and either 1,3- or 1,3,5-bromo- or iodobenzenes were found to be the most reliable in terms of convenience, selectivity and yield (dppf = 1,1'-bis(diphenylphosphino)ferrocene). These conditions also allowed the optimized syntheses of mixed (thienyl)(halo)benzenes, (T(n))C(6)H(3)X(2) and (T(n))(2)C(6)H(3)X (X = Br, I); the latter bromides could be further elaborated in subsequent Stille, Sonogashira, or Kumada reactions to furnish bis(thienyl) compounds bearing electron-donating or -withdrawing groups in the third meta position, (T(n))(2)C(6)H(3)R (R = Ph, p-MeOC(6)H(4), p-FC(6)H(4); n = 1, 2) and (T(1))(2)C(6)H(3)R' (R' = Me, C[triple bond]CPh, Fc; Fc = ferrocenyl). The relative effects of R, R', and n were evaluated by electronic spectroscopy, cyclic voltammetry and calculation. The absorption and emission characteristics and calculated ionization potentials and HOMO-LUMO gaps of these compounds were strongly dependent on n and largely insensitive to R/R'. These measured and calculated properties were also found to be largely invariant with respect to the degree of substitution about the central ring in the meta-substituted benzenes (T(n))(m)X(3-m)C(6)H(3) (m = 1-3; n = 1, 2; X = Br, H), although in the case of n = 1, there was a smooth, albeit small, increase in the emission maximum with increasing thienyl substitution. These findings essentially confirmed earlier theoretical predictions that the thienyl "arms" of meta-substituted phenyl-cored dendrimers were predominantly responsible for absorption and that excitons were localized to the "arms" without any electronic coupling between them, but also introduced the caveat that there was a minimum of two contiguous thiophene rings required for strict exciton localization to the arms. The oxidation potentials of the compounds in solution ranged from 0.9 to 1.6 V and were not rationally dependent on the degree of substitution or the nature of R/R'.
Development of a cellulose acetate hollow-fine-fibre membrane (2010)

The goal of this study is to produce cellulose acetate (CA) hollow-fine-fibre membranes with good water flux performance in the 95 -96% salt retention range for brackish water desalination from first principles.First, the acceptable range of fibre dimensions was determined by means of a collapse pressure calculation using the elastic buckling pressure equation (thin shell assumption).Second, the pressure drop across the fibre wall in the hollow-fine fibre was determined by using the Hagen-Poiseuille equation, in order to determine how this would affect the chosen fibre dimensions.It was determined that the acceptable range of fibre dimensions was 222 -247 m, and the wall thickness was 50 m.Fibres with these dimensions exhibited a high resistance to brackish water operating pressure of 20 -25 bar, without collapse.The pressure drop calculations of these dimensions showed a sufficiently low pressure drop across the fibres.A dry-wet spinning technique was used for the preparation of the hollow-fine-fibre membranes.Hollow-fine fibres were spun using CA dissolved in a suitable solvent and non-solvent mixture comprising acetone and formamide.The effects of the dope composition and spinning parameters such as solvent to non-solvent ratio, bore fluid ratio, take-up speed, dope extrusion rate and heat treatment on the membrane morphology and performance were investigated.The spun fibres showed a good morphological structure, with no macrovoids (sponge-like structure), which is favourable for reverse osmosis (RO) applications.The hollow-fine-fibre membranes showed a good brackish water desalination performance within brackish water operating conditions.Statistical analysis was used to generate a fabrication formulation for producing cellulose acetate hollow-fine-fibre membrane for brackish water desalination with improved salt retention and flux.A three-level three-factor factorial was used to the study of the effect of spinning parameters (solvent to non-solvent ratio, bore fluid ratio and air gap distance).A regression equation was successfully established and was used to predictably produce membranes with good performance within the limits of the factors studied.RO performance of these hollow-fine-fibre membranes was good: The salt retention ranged from 96 to 98% and the permeate flux ranged from 60 to 46 L/m 2 .d(2 000 ppm, NaCl, 20 bar, 24 o C).
New cotton varieties for Thai farmers (1997)

DORAS Project initiated in 1991 a cotton-breeding program in Thailand. After six years of breeding, the first wave of new variety creations is now available. The varieties were obtained by transferring into an agronomically well-adapted Thai genetic base (SSR 60) characters which improve its economic potential (gossypol free, coloured lint) or its agronomic quality (okra leaf, frego bract). These are the following varieties: DORA 11 (frego bract, highly productive, good earliness), DORA 21 (glandless seed, productive with a good tolerance to shedding, good fiber quality). DORA 31 (okra leaf. frego bract and good technological trails), DORA 41 (brown coloured fiber). DORA 11 may be adopted by farmers in the next years. Assessment of the other genotypes still needs additional experiments. As far as seed production of glandless varieties. like DORA 2 1, is concerned, avoidance of genetic mixing demands well-coordinated procedure.
A multiband 40nm CMOS LTE SAW-less modulator with &#x2212;60dBc C-IM3 (2013)

Due to the increasing demand for communication bandwidth combined with the scarceness of free spectrum, the complexity and versatility of 4 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> -generation modulation schemes is greater than ever. In particular, the LTE standard defines multiple RF bands and groups OFDM modulated subcarriers into Resource Blocks (RB) that can be flexibly used within the allocated channel bandwidth. When the transmitted power is concentrated in one or a few RBs, counter-intermodulation products (C-IM) may fall directly or through cross-modulation into the RX band and degrade FDD performance. They may also fall into protected bands and violate spectral emission requirements.
The ingestion of sow's faeces by suckling piglets (1981)

1. Six sows were housed in solid-floored farrowing pens and fed daily with approximately 200 microCi 198 Au, three of them from 3 d before farrowing until their piglets were 10 d old and three fr om 10 d after farrowing until their piglets were weaned at 21 d. 2. The sows' faeces and sawdust bedding became radioactive but their milk remained free of radioactivity. The piglets' radioactivity was measured daily in a whole-body counter after they had been washed to remove external contamination. 3. The piglets' mean whole-body radioactivity was equivalent to 20.9 +/- 2.5 g (range 5.7-85 g) of faeces and bedding. If the average passage time of the digesta through the gastrointestinal tract is assumed to be 24 h these values are equal to the average daily intake of faeces and bedding by the piglets. 4. This intake of faeces could possibly prevent the piglets becoming anaemic if the sow's diet were supplemented with iron to increase the Fe concentration of her faeces to approximately 2 mg Fe/g fresh faeces.
Diagnosis of diaphragm injuries using modern 256-slice CT scanners: too early to abandon operative exploration (2018)

I, diagnostic test or criteria.
Effects of hypoxia and hyperoxia on venous capacity and compliance in healthy men and women (2022)

Blood oxygen is an important modulator of arterial function, but its impact on peripheral venous function is incompletely understood. Herein, we sought to determine the effect of hypoxia and hyperoxia on venous capacity and compliance in the lower limb. In 16 healthy individuals (7 women; age: 28.3 ± 7.6 yr, mean ± SD), we assessed peripheral oxygen saturation ([Formula: see text]), the cross-sectional area (CSA) of the great saphenous vein (GSV; Doppler ultrasound), and calf volume (strain-gauge plethysmography) during a standard 60 mmHg thigh cuff inflation-deflation protocol. Separate trials were undertaken during breathing of room air, hypoxia [fraction in inspired oxygen ([Formula: see text]): 0.10], and hyperoxia ([Formula: see text]: 0.50), according to a single-blinded, randomized design. Lower limb pressure-CSA and pressure-volume relationships were modeled using a quadratic regression equation and compliance derived. [Formula: see text] was decreased by hypoxia (83.6 ± 5.6%) and increased by hyperoxia (98.7 ± 0.5%) compared with room air (96.4 ± 1.0%, P &lt; 0.001). Compared with room air (17.0 ± 7.9 mm 2 ), hypoxia decreased GSV CSA (13.4 ± 5.7 mm 2 , P &lt; 0.001), whereas no change was observed with hyperoxia (17.1 ± 8.7 mm 2 , P = 0.883). GSV compliance derived from the pressure-CSA relationships was elevated approximately twofold with hyperoxia (−0.0061 ± 0.0046 a.u.) when compared with room air (−0.0029 ± 0.002 a.u., P = 0.027) and hypoxia (−0.0030 ± 0.0032 a.u., P = 0.007). No differences were observed in calf pressure-volume parameters with either hypoxia or hyperoxia ( P &gt; 0.05). Our data indicate that GSV capacity is reduced by hypoxia, and that GSV compliance is increased by hyperoxia, thus highlighting the often overlooked role of oxygen in the regulation of venous circulation.
The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells (2007)

Loss of normal primary cilia function in mammals is linked to proliferative diseases, such as polycystic kidney disease, suggesting a regulatory relationship between cilia and cell cycle. The primary cilium expressed by most mammalian cells is nucleated from the elder centriole of the centrosome. The relationship between centrosome and cilia suggests that these structures share functions and components. We now show that IFT88/polaris, a component of the intraflagellar transport, remains associated to the centrosome in a proliferative state. IFT88/polaris is tightly associated with the centrosome throughout the cell cycle in a microtubule- and dynein-independent manner. IFT88/polaris tetratricopeptide repeat motifs are essential for this localization. Overexpression of IFT88/polaris prevents G1-S transition and induces apoptotic cell death. By contrast, IFT88/polaris depletion induced by RNA interference promotes cell-cycle progression to S, G2, and M phases. Finally, we demonstrate that IFT88/polaris interacts with Che-1, an Rb-binding protein that inhibits the Rb growth suppressing function. We propose that IFT88/polaris, a protein essential for ciliogenesis, is also crucial for G1-S transition in non-ciliated cells.
Dietary supplement based on stilbenes: a focus on gut microbial metabolism by the in vitro simulator M-SHIME® (2016)

Polyphenols and intestinal microbiota can influence each other, modifying metabolism and gut wellness. Data on this mutual effect need to be improved. Several studies on the biological activities of resveratrol and derivatives have been carried out, but the effects of a continuous administration of stilbenes on gut microbiota have not yet been investigated. This study evaluated the effects of an extract from Vitis vinifera, containing a combination of t-resveratrol and ε-viniferin, on intestinal microbiota, using the advanced gastrointestinal simulator M-SHIME®. A triple M-SHIME® experiment was performed using two concentrations of the extract (i.e. 1 and 2 g L<sup>-1</sup>), simulating a continuous daily intake. The effects were evaluated in terms of microbial functionality (SCFA and NH<sub>4</sub><sup>+</sup>) and composition (DGGE and Illumina sequencing), since the microbiological aspect has been less considered so far. The treatment induced changes in microbial functionality and composition. In fact, the levels of SCFA and NH<sub>4</sub><sup>+</sup> suffered a strong decrease (i.e. inhibition of the saccharolytic and proteolytic activity), while DGGE and Illumina showed important modifications of the microbiota composition, associated with an imbalance of the colonic microbiota (i.e. increase in the relative abundance of Enterobacteriaceae). HPLC-DAD-TOF-MS analyses demonstrated that the metabolism of t-resveratrol and other stilbenes was inhibited by continuous administration. Our results suggest M-SHIME® as an explorative tool to define the dosage of food supplements, in particular to simulate effective continuous administration in humans.
Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells (2016)

Energy metabolism in cancer cells is often increased to meet their higher proliferative rate and biosynthesis demands. Suppressing cancer cell metabolism using agents like metformin has become an attractive strategy for treating cancer patients. We showed that a novel ginsenoside derivative, Rh2E2, is as effective as aspirin in preventing the development of AOM/DSS-induced colorectal cancer and suppresses tumor growth and metastasis in a LLC-1 xenograft. A sub-chronic and acute toxicity LD50 test of Rh2E2 showed no harmful reactions at the maximum oral dosage of 5000 mg/kg body weight in mice. Proteomic profiling revealed that Rh2E2 specifically inhibited ATP production in cancer cells via down-regulation of metabolic enzymes involving glycolysis, fatty acid β-oxidation and the tricarboxylic acid cycle, leading to specific cytotoxicity and S-phase cell cycle arrest in cancer cells. Those findings suggest that Rh2E2 possesses a novel and safe anti-metabolic agent for cancer patients by specific reduction of energy-based metabolism in cancer cells.
Detection of the Potential Pancreatic Cancer Marker MUC4 in Serum Using Surface-Enhanced Raman Scattering (2011)

Pancreatic cancer (PC) is one of the most lethal malignancies. It has a 5-year survival rate of only 6%, owing in part to the lack of a reliable tumor marker for early diagnosis. Recent research has shown that the mucin protein MUC4 is aberrantly expressed in pancreatic adenocarcinoma cell lines and tissues but is undetectable in normal pancreas and chronic pancreatitis. Thus, the level of MUC4 in patient sera has the potential to function as a diagnostic and prognostic marker for PC. However, the measurement of MUC4 in sera using conventional test platforms (e.g., enzyme linked immunosorbent assay (ELISA) and radioimmunoassay (RIA)) has been unsuccessful. This has prevented the assessment of the utility of this protein as a possible PC marker in sera. In addressing this obstacle, the work herein examines the potential to create a simple diagnostic test for MUC4 through the development of a surface-enhanced Raman scattering (SERS)-based immunoassay, which was then used to demonstrate the first ever detection of MUC4 in cancer patient serum samples. Importantly, these measurements showed that sera from patients with PC produced a significantly higher SERS response for MUC4 compared to sera from healthy individuals and from patients with benign diseases. These results indicate that a SERS-based immunoassay can monitor MUC4 levels in patient sera, representing a much needed first step toward assessing the potential of this protein to serve as a serum marker for the early stage diagnosis of PC. This paper details these and other findings (i.e., the detection of the mucin protein CA19-9), which demonstrate that our SERS assay outperforms conventional assays (i.e., RIA and ELISA) with respect to limits of detection, readout time, and required sample volume.
Validity of a Self‐reported Periodontal Disease Measure (1996)

Dentists have a good perception of their periodontal status, and there is reasonable consensus among dentists regarding the threshold for defining periodontal disease. Self-reported measures might have potential for use in studies of other populations with substantial cost reduction, and deserve further evaluation.
Chemoselective Chromium(II)‐Catalyzed Cross‐Coupling Reactions of Dichlorinated Heteroaromatics with Functionalized Aryl Grignard Reagents (2014)

Chromium(II) chloride catalyzes the chemoselective cross-coupling reaction of dichloropyridines with a range of functionalized (hetero)aromatic Grignard reagents at room temperature. Functional groups, such as esters and acetals, are well tolerated in this transformation. Previously challenging substrates, quinolines and isoquinolines, participate in the selective Cr-catalyzed cross-coupling in cyclopentyl methyl ether (CPME) as the solvent. The effective purging of Cr salts is demonstrated by using various solid supports.