gebhart/patrepeval huggingface dataset:
Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis (2005)

Although the recent identification of several genes has extended our knowledge on the maintenance of body iron homeostasis, their tissue specific expression patterns and the underlying regulatory networks are poorly understood. We studied C57black/Sv129 mice and HFE knockout (HFE -/-) variants thereof as a model for hemochromatosis, and investigated the expression of iron metabolism genes in the duodenum, liver, and kidney as a function of dietary iron challenge. In HFE +/+ mice dietary iron supplementation increased hepatic expression of hepcidin which was paralleled by decreased iron regulatory protein (IRP) activity, and reduced expression of divalent metal transporter-1 (DMT-1) and duodenal cytochrome b (Dcytb) in the enterocyte. In HFE -/- mice hepcidin formation was diminished upon iron challenge which was associated with decreased hepatic transferrin receptor (TfR)-2 levels. Accordingly, HFE -/- mice presented with high duodenal Dcytb and DMT-1 levels, and increased IRP and TfR expression, suggesting iron deficiency in the enterocyte and increased iron absorption. In parallel, HFE -/- resulted in reduced renal expression of Dcytb and DMT-1. Our data suggest that the feed back regulation of duodenal iron absorption by hepcidin is impaired in HFE -/- mice, a model for genetic hemochromatosis. This change may be linked to inappropriate iron sensing by the liver based on decreased TfR-2 expression, resulting in reduced circulating hepcidin levels and an inappropriate up-regulation of Dcytb and DMT-1 driven iron absorption. In addition, iron excretion/reabsorption by the kidneys may be altered, which may aggravate progressive iron overload.
Organosoluble, segmented rigid-rod polyimide film. 1. Structure formation (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganosoluble, segmented rigid-rod polyimide film. 1. Structure formationStephen Z. D. Cheng, Fred E. Arnold Jr., Anqiu Zhang, Steve L. C. Hsu, and Frank W. HarrisCite this: Macromolecules 1991, 24, 21, 5856–5862Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://doi.org/10.1021/ma00021a021RIGHTS & PERMISSIONSArticle Views662Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Cochlear electrical model for the interpretation of tinnitus (2005)

If a model for the auditory system from the ear canal to the auditory cortex could be established, it would be a great contribution to the diagnosis and treatment of tinnitus patients. In this study, existing models for the auditory system were examined, and a model which can best explain tinnitus phenomena was established. In a new model, the reticular lamina, a thin fluid layer which transmits energy in a cochlea, was assumed as a mass and components for the stiffness and control were added to the model. Mathematical interpretation was performed to compare the zeros and poles of the transfer function between existing models and newly designed model. The results showed that the values of zeros were lower than that of the poles which coincides with the results obtained from animal neural data.
An SH0 lithium niobate trans-impedance chirp compressor with high voltage gain (2018)

We present a new type of acoustic devices that, for the first time, can simultaneously perform chirp compression and impedance transformation to achieve passive voltage amplification with a gain of 12. The device consists of an acoustic dispersive delay line (DDL) based on shear-horizontal waves (SH0) in lithium niobate (LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ). SH0 waves are employed due to their demonstrated high electromechanical coupling (k <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) of 39%, low propagation loss, and a slow phase velocity of 3700 m/s. As a result of these desirable features, the fabricated device demonstrates a large fractional bandwidth (FBW) of 50%, a low insertion loss (IL), a high processing gain (TB) of 76, and a compact size of 1.57 by 0.23 mm. In addition to the compression, the device harnesses an asymmetrical transduction scheme to provide a compounding voltage gain from impedance transformation. Consequently, it results in a much higher voltage at the device output, which can be exploited to attain a higher sensitivity for wake-up radio receivers.
Re-Ingestion of Upstream Egress in a 1.5-Stage Gas Turbine Rig (2017)

In gas turbines, rim seals are fitted at the periphery of stator and rotor discs to minimise the purge flow required to seal the wheel-space between the discs. Ingestion (or ingress) of hot mainstream gases through rim seals is a threat to the operating life and integrity of highly-stressed components, particularly in the first-stage turbine. Egress of sealing flow from the first-stage can be re-ingested in downstream stages. This paper presents experimental results using a 1.5-stage test facility designed to investigate ingress into the wheel-spaces upstream and downstream of a rotor disc. Re-ingestion was quantified using measurements of CO2 concentration, with seeding injected into the upstream and downstream sealing flows. Here a theoretical mixing model has been developed from first principles and validated by the experimental measurements. For the first time, a method to quantify the mass fraction of the fluid carried over from upstream egress into downstream ingress has been presented and measured; it was shown that this fraction increased as the downstream sealing flow rate increased. The upstream purge was shown to not significantly disturb the fluid dynamics but only partially mixes with the annulus flow near the downstream seal, with the ingested fluid emanating from the boundary layer on the blade platform. From the analogy between heat and mass transfer, the measured mass-concentration flux is equivalent to an enthalpy flux and this re-ingestion could significantly reduce the adverse effect of ingress in the downstream wheel-space. Radial traverses using a concentration probe in and around the rim seal clearances provide insight into the complex interaction between the egress, ingress and mainstream flows.
Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice (2014)

These results indicate that Rho-kinase inhibition ameliorates metabolic disorders through activation of the LKB1/AMPK pathway, suggesting that Rho-kinase is also a novel therapeutic target of metabolic disorders.
Left atrial function: physiology, assessment, and clinical implications (2011)

The interest in the left atrium (LA) has resurged over the recent years. In the early 1980s, multiple studies were conducted to determine the normal values of LA size. Over the past decade, LA size as an imaging biomarker has been consistently shown to be a powerful predictor of outcomes, including major public health problems such as atrial fibrillation, heart failure, stroke, and death. More recently, functional assessment of the LA has been shown to be, at least as, if not more robust, a marker of cardiovascular outcomes. Current available data suggest that the combined evaluation of LA size and LA function will augment prognostication. The aim of this review is to provide a critical appraisal of current echocardiographic techniques for the assessment of LA function and the implications of such assessment for prediction and disease prevention.
30-mJ, diode-pumped, chirped-pulse Yb:YLF regenerative amplifier (2003)

A diode-pumped chirped-pulse regenerative amplifier with a cooled Yb:YLF crystal has been developed. The output pulse energy is 30 mJ at 20-Hz repetition rate. A high effective extraction efficiency of 68% is obtained, which is attributed to reduced saturation fluence at low temperature and to a high effective pulse energy fluence during regenerative amplification. After pulse compression by use of a parallel grating pair, 18-mJ pulse energy and 795-fs pulse duration are obtained.
Trinidad Mud Volcanoes (2011)

The phenomenon of rocks moving under their own means has always fascinated both scientists and nonscientists alike. The 2006 AAPG Hedberg Conference on Mobile Shale Basins was held in response to a need to gather industry and academic communities in a common forum to address the very existence of mobile shales. Stimulating and informative discussions at that Conference led to this special volume on shale tectonics. AAPG Memoir 93 documents shale tectonics from a variety of basins around the world, including the southern Beaufort Sea; the Krishna-Godavari Basin, India; eastern offshore Trinidad; offshore Brunei; and along the westernmost portion of the Mediterranean Sea. The book also provides information on the petrographic framework, behavior, geometries, and geodynamic models of shales. Publication of this Memoir coincides with a growing interest in shales as hydrocarbon reservoirs, and will add to the body of literature that significantly addresses both extrusive and intrusive shales.
Negative Thermal Expansion in Ultrathin Plasma Polymerized Films (Postprint) (2007)

Because of the increasing applications of polymer films with nanoscale thickness, it is imperative to fully characterize the physical properties in these films, which could be significantly different from the bulk properties due to the surface and interfacial effects. Interactions with the substrate and high specific surface area (film/air and film/substrate) can cause peculiar properties of the ultrathin polymer films. In a recent study the glass transition of a free standing and supported PS film was found to vary significantly with thickness. Other studies have unveiled several interesting phenomena such as the depth dependent glass transition temperature and thickness dependent thermal expansion. It has been reported that substrate interactions alter the thermal properties of ultrathin poly-(2)-vinylpyridine films. A non monotonic thermal behavior was observed in ultrathin polycarbonate films with a negative and positive thermal expansion below and above glass transition temperature, respectively.
Modification of lignin (1988)

Abstract Wood is a composite material in which lignin forms the adhesive and reinforcing component. The paper describes varous ways to modify the isolated or degraded lignin to useful polymeric products. As an example of complex reaction systems the association reactions and pre‐equilibria of lignin with sulphur dioxide are discussed.
Measuring the lengthening kinetics of aligned nanostructures by spatiotemporal correlation of height and orientation (2010)

Owing to their inherent tortuosity, the collective height of vertically aligned nanostructures does not equal the average length of the individual constituent nanostructures, and therefore temporal height measurement is not an accurate measure of the genuine growth kinetics. We use high-resolution spatial mapping of alignment by small-angle X-ray scattering (SAXS) to transform real-time measurements of array height to the average length of the nanostructures. Applying this approach to carbon nanotube (CNT) forest growth transforms the kinetics from a sub-linear to a linear relationship with time, highlighting the potential for insights into the limiting growth mechanisms of CNTs and other one-dimensional nanostructures.
Impact of tunability and blocking fabric on optical slot switching ring performance (2016)

Optical slot switching rings have been proposed as optical transport networks for segments subject to rapid traffic variations and latency restriction. In order to achieve any-to-any node communication over the ring, optical slot switching networks rely on fast wavelength tunable lasers. With the introduction of the coherent technology, fast wavelength tunability is now available at the receiver side. Additionally, optical slot switching nodes may use a slot blocker that can block any slot on any wavelength. In this paper we investigate the impact on the network performance of the optical part of the slot switching node, both in terms of location of the fast wavelength tunable element and of the presence of the slot blocker.
Regulatory T cell hybridoma reveal novel Foxp3 inducing factors (139.7) (2010)

Abstract It has been difficult to generate cloned regulatory T cells (Tregs) or Treg hybridoma for the studies on antigen specificity and the regulation of Foxp3 by TCR independent factors. Here, we report the first successful generation of cloned, inducible Treg hybridomas (iTreg-hyb) using the CD4+ T cells of TCR transgenic DO11.10 mice bearing the Foxp3-IRES-eGFP knock-in gene. Although, the iTreg-hyb expressed low Foxp3-GFP, strong expression could be induced by either polyclonal (using anti-CD3 mAb) or antigen specific (using OVA[323-339] peptide presented by syngeneic Rag2 deficient spleen cells) TCR stimulation in the presence of Interleukin (IL) -2 and Transforming Growth Factor-β1. Interestingly, CD11c+ cells isolated from the spleens of Rag2 deficient mice alone could induce Foxp3-GFP expression, albeit with 30-fold lower efficiency. The induction of Foxp3-GFP by the latter mechanism was specific as it did not up-regulate the TCR stimulation dependent Treg associated markers. Using the iTreg-hyb, we have identified several Foxp3 inducing factors which include recombinant IL-6, IL-9, IL-27, and a &amp;lt;5-kd soluble factor produced by Rag2 deficient spleen cells. Our study shows that it is feasible to generate iTreg-hyb, which is useful not only to study the role of self-reactivity but also to uncover TCR independent pathways for the induction of Foxp3 expression by cytokines and novel factors.
A review of recent developments in natural fibre composites and their mechanical performance (2015)

Recently, there has been a rapid growth in research and innovation in the natural fibre composite (NFC) area. Interest is warranted due to the advantages of these materials compared to others, such as synthetic fibre composites, including low environmental impact and low cost and support their potential across a wide range of applications. Much effort has gone into increasing their mechanical performance to extend the capabilities and applications of this group of materials. This review aims to provide an overview of the factors that affect the mechanical performance of NFCs and details achievements made with them.
Establishing EMC Education: The Ten-Year Contribution of the University Grant Program (2007)

The University Grant Program was first funded by the IEEE EMC Society in 1997. Over the past 10 years it has provided seed money for the establishment of eight courses in the basic principles of electromagnetic compatibility at academic institutions on two continents. All past recipients were surveyed, and the collected data was used to assess the impact and exceptional return on investment of the program. Brief descriptions of some of the experiments developed are also included.
Diagnostic Cerebral Angiography: Archaic and Complication-Prone or Here to Stay for Another 80 Years? (2008)

Diagnostic Cerebral Angiography: Archaic and Complication-Prone or Here to Stay for Another 80 Years?Timothy J. Kaufmann1 and David F. KallmesAudio Available | Share
Synthesis and antiallergy activity of 5-oxo-5H-thiazolo[2,3-b]quinazolinecarboxylic acids (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antiallergy activity of 5-oxo-5H-thiazolo[2,3-b]quinazolinecarboxylic acidsRonald A. LeMahieu, Mathew Carson, Ann F. Welton, Herman W. Baruth, and Bohdan YaremkoCite this: J. Med. Chem. 1983, 26, 1, 107–110Publication Date (Print):January 1, 1983Publication History Published online1 May 2002Published inissue 1 January 1983https://doi.org/10.1021/jm00355a022RIGHTS & PERMISSIONSArticle Views157Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (504 KB) Get e-Alerts Get e-Alerts
Net flux sensors for the measurement of Mars surface radiation budget (2012)

This paper reports on a net flux sensor being devised as part of a network of meteorological sensors for the acquisition of surface data of Mars. The characteristics of the measuring configuration and source of error that drive the sensor design are examined. The pyranometers and pyrgeometers of the sensor use double platform microbolometers with gold black coating for the measurement of radiative fluxes in the spectral range from 0.3 to 50 &#956;m. The microbolometer detector exhibits a typical responsivity of ~ 1.8&times;10<sup>4</sup> V/W and a time constant of ~ 14 ms at the pixel level. The reflectance data confirm that the gold black absorbs more than 98 % of the incident light in the range from 0.2 to 20 &#956;m, while the absorptance exceeds 94% for wavelengths up to 100 &#956;m. The detector transfer function is derived to assist in the characterization of net flux sensor. The experimental sensor modules, which differ in the spectral band and field of view, are designed to be interchangeable on the same node of a sensor network. The network is intended for the evaluation of the sensor performance and measurement configuration in analog field experiments.
Process Identification in THOTH (1979)

A scheme is presented for the identification of processes in a minicomputer operating system. This scheme was designed and implemented as part of the development of the Thoth operating system. The scheme is efficient in time and space as well as exhibiting a reasonable lower bound on the minimum recycle time for process identifiers.
Medial Septal Nucleus Theta Frequency Deep Brain Stimulation Improves Spatial Working Memory after Traumatic Brain Injury (2012)

More than 5,000,000 survivors of traumatic brain injury (TBI) live with persistent cognitive deficits, some of which likely derive from hippocampal dysfunction. Oscillatory activity in the hippocampus is critical for normal learning and memory functions, and can be modulated using deep brain stimulation techniques. In this pre-clinical study, we demonstrate that lateral fluid percussion TBI results in the attenuation of hippocampal theta oscillations in the first 6 days after injury, which correlate with deficits in the Barnes maze spatial working memory task. Theta band stimulation of the medial septal nucleus (MSN) results in a transient increase in hippocampal theta activity, and when delivered 1 min prior to training in the Barnes maze, it significantly improves spatial working memory. These results suggest that MSN theta stimulation may be an effective neuromodulatory technique for treatment of persistent learning and memory deficits after TBI.
Chapter 4. The Intersection of Human Rights, Social Justice, the Internet, and Accessibility in Libraries: Access, Education, and Inclusion (2017)

Chapter 4. The Intersection of Human Rights, Social Justice, the Internet, and Accessibility in Libraries: Access, Education, and Inclusion was published in Disability, Human Rights, and Information Technology on page 58.
Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury. (1992)

Tenascin is an extracellular matrix molecule synthesized and released by young astrocytes during embryonic and early postnatal development of the nervous system, and it is concentrated in boundaries around emerging functional neuronal units. In the adult nervous system, tenascin can be detected only in very low levels. Distinct spatial and temporal distributions of tenascin during developmental events suggest a role in the guidance and/or segregation of neurons and their processes within incipient functional patterns. We show here, using in situ hybridization and immunocytochemistry, that stab wounds of the adult mouse cerebellar and cerebral cortices result in an enhanced expression of tenascin in a discrete region around the lesion site that is associated with a subset of glial fibrillary acidic protein-positive astrocytes. Tenascin up-regulation in the lesioned adult brain may be directly involved in failed regeneration or indirectly involved through its interactions with other glycoconjugates that either inhibit or facilitate neurite growth.
Homocysteine up‐regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivo (2008)

Hyperhomocysteinemia up-regulates CXCL16 leading to increased recruitment of CXCR6(+) lymphocytes and scavenging of modified lipids via a potential involvement of a PPAR-gamma-dependent mechanism. CXCL16 may therefore contribute to the formation and progression of atherosclerotic lesions under conditions of hyperhomocysteinemia.
A dynamic multicast routing algorithm with load-balance and minimum bandwidth cost under delay constraint (2011)

Multicast services are becoming more popular in the current network. As a result, the multicast routing algorithm which is load-balanced and minimum bandwidth resource will be more important since the bandwidth resource is seriously scarce and the network load is imbalance. To solve these problems, this paper proposes a dynamic multicast routing algorithm for minimum bandwidth cost and load-balanced under delay constraint, which is called DCLB. With abundant of simulation experiments by MATLAB, the experiment results show that the algorithm DCLB can save bandwidth resource as well as accomplish load-balance under the exact delay constraint. Such algorithm can meet the desired network requirements well.