gebhart/patrepeval huggingface dataset:
ALX Polymer for Wafer Level Packaging: Mechanical Property Evaluation After Multiple Lead-Free Solder Reflows (2010)

For bumping and wafer level packaging (WLP) applications, BCB and polyimide are the predominant spin-on dielectric materials used for re-passivation, redistribution, interlayer dielectric, and stress buffer layers. Each of these materials has their respective strengths and weaknesses. BCB has exceptionally low shrinkage on cure and moisture absorption, low curing temperature, and a low dielectric constant, but is a mechanically brittle material which limits its application in bump-on-polymer applications. Polyimides are superior mechanically to BCB and are utilized more in bump-on-polymer structures, but suffer from much higher shrinkage on cure and moisture absorption (which can lead to blistering if not carefully processed), have higher dielectric constants, and have much higher cure temperatures. ALX spin-on polymer dielectric was developed to combine low shrinkage, low moisture absorption, low dielectric constant, and excellent mechanical and stress buffering properties with a cure temperature between 190C to 250C, depending on the application(1-3). Previous papers have reported the mechanical properties at 190C and the application of ALX in eutectic SnPb solder bump structures. The use of lead-free solder requires reflow temperatures up to 260C. Although ALX polymer is curable at less than 200C, the influence of lead-free solder reflow wasnft investigated. In this presentation we evaluate mechanical property changes of ALX Polymer films after different cure schedules and multiple reflows at lead-free solder temperatures. The impact of these parameters on WLP will be discussed.
DeepCAS: A Deep Reinforcement Learning Algorithm for Control-Aware Scheduling (2018)

We consider networked control systems consisting of multiple independent controlled subsystems, operating over a shared communication network. Such systems are ubiquitous in cyber-physical systems, Internet of Things, and large-scale industrial systems. In many large-scale settings, the size of the communication network is smaller than the size of the system. In consequence, scheduling issues arise. The main contribution of this letter is to develop a deep reinforcement learning-based control-aware scheduling (DEEPCAS) algorithm to tackle these issues. We use the following (optimal) design strategy: first, we synthesize an optimal controller for each subsystem; next, we design a learning algorithm that adapts to the chosen subsystems (plants) and controllers. As a consequence of this adaptation, our algorithm finds a schedule that minimizes the control loss. We present empirical results to show that DEEPCAS finds schedules with better performance than periodic ones.
Comparative Contents of Dietary Fiber, Total Phenolics, and Minerals in Persimmons and Apples (2001)

Dietary fibers, major phenolics, main minerals, and trace elements in persimmons and apples were analyzed and compared in order to choose a preferable fruit for an antiatherosclerotic diet. Fluorometry and atomic absorption spectrometry following microwave digestion were optimized for the determination of major phenolics and minerals. Total, soluble, and insoluble dietary fibers, total phenols, epicatechin, gallic and p-coumaric acids, and concentrations of Na, K, Mg, Ca, Fe, and Mn in whole persimmons, their pulps, and peels were significantly higher than in whole apples, pulps, and peels (P < 0.01-0.0025). Conversely, the contents of Cu and Zn were higher in apples than in persimmons. In persimmons and apples all of the above components were higher in their peels than in whole fruits and pulps. The relatively high contents of dietary fibers, total and major phenolics, main minerals, and trace elements make persimmon preferable for an antiatherosclerotic diet.
Electrochemiluminescence Amplification in Bead-Based Assays Induced by a Freely Diffusing Iridium(III) Complex (2023)

Heterogeneous electrochemiluminescence (ECL) assays employing tri-<i>n</i>-propylamine as a co-reactant and a tris(2,2'-bipyridine)ruthenium(II) ([Ru(bpy)<sub>3</sub>]<sup>2+</sup>) derivative as an emissive label are integral to the majority of academic and commercial applications of ECL sensing. This model system is an active research area and constitutes the basis of successfully commercialized bead-based ECL immunoassays. Herein, we propose a novel approach to the enhancement of such conventional ECL assays <i>via</i> the incorporation of a second metal coordination complex, [Ir(sppy)<sub>3</sub>]<sup>3-</sup> (where sppy = 5'-sulfo-2-phenylpyridinato-<i>C</i><sup>2</sup>,<i>N</i>), to the experimental system. By employing ECL microscopy, we are able to map the spatial distribution of ECL emission at the surface of the bead, from [Ru(bpy)<sub>3</sub>]<sup>2+</sup> labels, and solution-phase emission, from [Ir(sppy)<sub>3</sub>]<sup>3-</sup>. The developed [Ir(sppy)<sub>3</sub>]<sup>3-</sup>-mediated enhancement approach elicited a significant improvement (70.9-fold at 0.9 V and 2.9-fold at 1.2 V vs Ag/AgCl) of the ECL signal from [Ru(bpy)<sub>3</sub>]<sup>2+</sup> labels immobilized on the surface of a polystyrene bead. This dramatic enhancement in ECL signal, particularly at low oxidation potentials, has important implications for the improvement of existing heterogeneous ECL assays and ECL-based microscopy, by amplifying the signal, opening new bioanalytical detection schemes, and reducing both electrode surface passivation and deleterious side reactions.
Visual Showcase: An Illustrative Data Graphic in an 18th-19th Century Style (2013)

We exhibit an data graphic poster that emulates the style of historic hand-made visualizations of the 18th–19th century. Our visualization uses real data and employs style elements such as an emulation of ink lines, hatching and cross-hatching, appropriate typesetting, and unique style of computer-assisted facial drawings. 1
UNIVERSITY RESEARCH PROGRAM IN ROBOTICS, Final Technical Annual Report, Project Period: 9/1/04 - 8/31/05 (2006)

The University Research Program in Robotics (URPR) Implementation Plan is an integrated group of universities performing fundamental research that addresses broad-based robotics and automation needs of the NNSA Directed Stockpile Work (DSW) and Campaigns. The URPR mission is to provide improved capabilities of robotics science and engineering to meet the future needs of all weapon systems and other associated NNSA/DOE activities.
Targeted Deep Sequencing of Mycosis Fungoides Reveals Intracellular Signaling Pathways Associated with Aggressiveness and Large Cell Transformation (2021)

Our data demonstrate that LCT transition of MF is associated with increased frequency of somatic mutations in cancer-associated genes. In particular, the activation of RAS signaling-together with epigenetic dysregulation-may crucially contribute to the molecular pathogenesis of the LCT phenotype, thus conveying its adverse clinical behavior.
Procedimientos de diseño en mecatrónica (2011)

Ingeniería Investigación y Tecnología es una publicación trimestral, arbitrada, de investigación científica y tecnológica editada e impresa por la Facultad de Ingeniería de la UNAM. Su propósito es difundir información y conocimientos originales e inéditos relacionados con la ingeniería. Es un espacio para profesores, investigadores, profesionales y estudiantes de todo el mundo.
THz detectors based on Si-CMOS technology field effect transistors – advantages, limitations and perspectives for THz imaging and spectroscopy (2018)

International audience
Isaac Newton: Historian (1964)

Find information about UTP Journals. University of Toronto Press is Canada’s leading academic publisher and one of the largest university presses in North America, with particular strengths in the social sciences, humanities, and business. The Book Publishing Division is widely recognized in Canada for its strength in history, political science, sociology, Indigenous studies, and cultural studies. Internationally, UTP is a leading publisher of medieval, Renaissance, Italian, Iberian, Slavic, and urban studies, as well as studies in book and print culture.
Task planning for a mobile robot in an indoor environment using object-oriented domain information (1997)

For a mobile robot to be practical, it needs to navigate in dynamically changing environments and manipulate objects in the environment with operating ease. The main challenges to satisfying these requirements in mobile robot research include the collection of robot environment information, storage and organization of this information, and fast task planning based on available information. Conventional approaches to these problems are far from satisfactory due to their requirement of high computation time. In this paper, we specifically address the problems of storage and organization of the environment information and fast task planning in the area of robotic research. We propose an special object-oriented data model (OODM) for information storage and management in order to solve the first problem. This model explicitly represents domain knowledge and abstracts a global perspective about the robot's dynamically changing environment. To solve the second problem, we introduce a fast task planning algorithm that fully uses domain knowledge related to robot applications and to the given environment. Our OODM based task planning method presents a general frame work and representation, into which domain specific information, domain decomposition methods and specific path planners can be tailored for different task planning problems. This method unifies and integrates the salient features from various areas such as database, artificial intelligence, and robot path planning, thus increasing the planning speed significantly.
Total Synthesis of Apratoxin A. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Linen Industry of Shropshire (1981)

The discovery in 1975 of part of Charles Bage's iron framed Castlefields flax mill led the author to study Shropshire's other linen factories and the domestic manufacture of linen and ropes during the seventeenth, eighteenth and nineteenth centuries. The manufacture of linen by cottagers and farmers from home grown hemp survived, alongside the factories, into the nineteenth century. The hempen cloth produced in Shropshire was rarely sold at markets or fairs, and was made mainly by country families for their own use. The survival of such a cottage industry into the nineteenth century was rare in England, and the existence of a workforce skilled in the preparation and manufacture of hemp and flax was probably one of the factors which influenced Shropshire entrepreneurs to manufacture linen in their factories, rather than cotton.
A CD30-positive T cell line established from an aggressive anaplastic large cell lymphoma, originally diagnosed as Hodgkin's disease. (1994)

Ten months following the diagnosis of Hodgkin's disease (HD), a 46-year-old woman presented cutaneous and leukemic involvement by CD30+ anaplastic large cells, from which a continuously growing, exogenous growth factor-independent T cell line was established. The cultured cells are phenotypically and genotypically T cell in type, negative for EBV, HTLV-I and HTLV-II viral sequences, and release soluble CD30 into the supernatant. Karyotype analysis disclosed several chromosomal abnormalities, but none on chromosome 5q. The involvement of the short arm of chromosome 17 prompted us to investigate the TP53 gene by means of the polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) analysis, but no alterations were found in exons 5-8.
Sodium transfer from endolymph through a luminal amiloride-sensitive channel (1989)

An in vitro preparation of frog semicircular canal was devised to study the mechanisms of Na transport across the labyrinthine epithelium. When the lumen of the semicircular canal was filled with perilymph-like solution, the structure was able to secrete K into and to absorb Na from the lumen and to generate a lumen-positive transepithelial potential. When the lumen of the semicircular canal was filled with endolymph-like solution, the electrochemical composition of the luminal fluid was partly maintained up to 2 h. In this last experimental condition net and unidirectional fluxes were calculated in absence or presence of transport inhibitors, separately for the ampulla and for the nonampullar part of the canal. Amiloride (10(-5) M) but not dimethyl amiloride (10(-5) M) inhibited 60% of the unidirectional Na efflux out of endolymph; this Na efflux decrease resulted in an increase of the inward net Na flux. The net Na flux was also increased after abluminal application of ouabain (10(-3) M), furosemide (10(-4) M), and bumetanide (10(-6) M). This study validates this isolated preparation as a suitable tool for the study of endolymph secretion, confirms that the secretion of endolymph is achieved in the ampulla, and provides evidence for an apical amiloride-sensitive Na channel through which Na is transferred out of endolymph along an electrochemical gradient provided by the activity of the abluminal Na+-K+-ATPase.
Modular Controllability Verification Using Language Projection (2015)

Model Checking is the task of searching the state spaces of finite-state automata to see whether they satisfy certain properties of interest. In many practical applications, the state space is much larger than can possibly be fit in the memory of a computer. One of the methods developed to overcome this problem and make it possible to verify large models is the so-calledmodular method. This paper presents a new algorithm which is capable of reducing the state space by orders of magnitude using projection. The new algorithm can be used separately or in combination with the modular method. It has been tested on a large set of real-world in-dustrial models of very large size, and is capable of solving at least one model that has not been solved before.
Glutathione-Responsive Prodrug Nanoparticles for Effective Drug Delivery and Cancer Therapy (2018)

Spurred by recent progress in medicinal chemistry, numerous lead compounds have sprung up in the past few years, although the majority are hindered by hydrophobicity, which greatly challenges druggability. In an effort to assess the potential of platinum (Pt) candidates, the nanosizing approach to alter the pharmacology of hydrophobic Pt(IV) prodrugs in discovery and development settings is described. The construction of a self-assembled nanoparticle (NP) platform, composed of amphiphilic lipid-polyethylene glycol (PEG) for effective delivery of Pt(IV) prodrugs capable of resisting thiol-mediated detoxification through a glutathione (GSH)-exhausting effect, offers a promising route to synergistically improving safety and efficacy. After a systematic screening, the optimized NPs (referred to as P6 NPs) exhibited small particle size (99.3 nm), high Pt loading (11.24%), reliable dynamic stability (∼7 days), and rapid redox-triggered release (∼80% in 3 days). Subsequent experiments on cells support the emergence of P6 NPs as a highly effective means of transporting a lethal dose of cargo across cytomembranes through macropinocytosis. Upon reduction by cytoplasmic reductants, particularly GSH, P6 NPs under disintegration released sufficient active Pt(II) metabolites, which covalently bound to target DNA and induced significant apoptosis. The PEGylation endowed P6 NPs with in vivo longevity and tumor specificity, which were essential to successfully inhibiting the growth of cisplatin-sensitive and -resistant xenograft tumors, while effectively alleviating toxic side-effects associated with cisplatin. P6 NPs are, therefore, promising for overcoming the bottleneck in the development of Pt drugs for oncotherapy.
Letter to the editor: Response to letter from Dr. Martin et al: Not ready for prime time: Intermittent versus partial REBOA for prolonged hemorrhage control in a highly lethal porcine injury model (2020)

Johnson, Michael Austin MD, PhD; Hoareau, Guillaume DVM, PhD; Williams, Timothy K. MD; Neff, Lucas P. MD Author Information
Resistance to high-fat diet in the female progeny of obese mice fed a control diet during the periconceptual, gestation, and lactation periods (2006)

With the worldwide epidemic of metabolic syndrome (MetS), the proportion of women that are overweight/obese and overfed during pregnancy has increased. The resulting abnormal uterine environment may have deleterious effects on fetal metabolic programming and lead to MetS in adulthood. A balanced/restricted diet and/or physical exercise often improve metabolic abnormalities in individuals with obesity and type 2 diabetes mellitus (T2D). We investigated whether reducing fat intake during the periconceptual/gestation/lactation period in mothers with high-fat diet (HFD)-induced obesity could be used to modify fetal/neonatal MetS programming positively, thereby preventing MetS. First generation (F1) C57BL/6J female mice with HFD-induced obesity and T2D were crossed with F1 males on control diet (CD). These F1 females were switched to a CD during the periconceptual/gestation/lactation period. At weaning, both male and female second generation (F2) mice were fed a HFD. Weight, caloric intake, lipid parameters, glucose, and insulin sensitivity were assessed. Sensitivity/resistance to the HFD differed significantly between generations and sexes. A similar proportion of the F1 and F2 males (80%) developed hyperphagia, obesity, and T2D. In contrast, a significantly higher proportion of the F2 females (43%) than of the previous F1 generation (17%) were resistant (P<0.01). Despite having free access to the HFD, these female mice were no longer hyperphagic and remained lean, with normal insulin sensitivity and glycemia but mild hypercholesterolemia and glucose intolerance, thus displaying a "satiety phenotype." This suggests that an appropriate dietary fatty acid profile and intake during the periconceptual/gestation/lactation period helps the female offspring to cope with deleterious intrauterine conditions.
Fast calculation of images for high numerical aperture lithography (2004)

Many hitherto small effects will become numerically significant in lithography at 70nm and below. The simple assumptions of scalar imaging and uniformly-polarized sources will no longer be tenable. Contrast losses in the resist (e.g. by diffusion) will become appreciable. In addition, the elements of 157nm lenses will be intrinsically polarizing due to spatial dispersion in CaF2, and in general lenses will exhibit residual polarization aberrations. We show here that these effects can be accounted for in a fast "sum-of-coherent-systems" (SOCS) algorithm that is suitable for model-based optical proximity correction (MBOPC). First, we cast the classic equations of vector image formation in a new form that explicitly distinguishes scalar and vector field terms. Lens birefringence is then added to the model; in doing so we take into account the classic phenomenon of double refraction, wherein a given ray splits into two rays each time it passes through an element. In principle, each incident ray then gives rise to an extended family of rays in the exit pupil. However, we show that this coherent set of rays can be merged into a single plane-wave component of the image, allowing a Jones matrix pupil to be defined. Once the vector imaging equations are modified to accommodate customized polarization distributions in the source as well as matrix pupils in the lens, we show that tractable SOCS kernels can be obtained under a generalization of the thin-mask approximation. Such models can be extended to include non-optical effects like resist blur, along with empirical modeling terms. We also discuss computational efficiencies that can be achieved when calculating SOCS kernels, for example by iteratively refining kernels calculated from a reduced basis, and by exploiting system symmetry (radial, dipole, or quadrupole).
Molecular cloning and characterization of a sym plasmid locus that regulates cultivar‐specific nodulation of soybean by Rhizobium fredii USDA257 (1993)

Rhizobium fredii strain USDA257 produces nitrogen-fixing nodules on primitive soybean cultivars such as Peking but fails to nodulate agronomically improved cultivars such as McCall. Transposon-mutant 257DH4 has two new phenotypes: it nodulates McCall, and its ability to do so is sensitive to the presence of parental strain USDA257, i.e. it is subject to competitive nodulation blocking. We have isolated a cosmid containing DNA that corresponds to the site of transposon insertion in 257DH4 and have localized Tn5 on an 8.0 kb EcoRI fragment. The 5596 bp DNA sequence that surrounds the insertion site contains seven open reading frames. Five of these, designated nolBTU, ORF4, and nolV, are closely spaced and of the same polarity. nolW and nolX are of the opposite polarity. The initiation codon for nolW lies 155 bp upstream from that of nolB, and its is separated from nolX by 281 bp. The predicted NolT and NolW proteins have putative membrane-spanning regions. The N-terminus of the hypothetical NolW protein also has limited homology to NodH of Rhizobium meliloti, but none of the deduced protein sequences has significant homology to known nodulation gene products. Site-directed mutagenesis with mudII1734 confirms that inactivation of nolB, nolT, nolU, nolV, nolW, or nolX extends host range for nodulation to McCall soybean. This phenotype could not be genetically dissected from sensitivity to competitive nodulation blocking. Expression of nolBTU and nolX is induced as much as 30-fold by flavonoid signal molecules, even though these genes lack nod-box promoters. Histochemical staining of McCall roots inoculated with nolB-, nolU-, or nolX-lacZ fusions verifies that these genes are expressed continuously from preinfection to the stage of the functional nodule. Although a nolU-ORF4-nolV clone hybridizes to a single 8.0 kb EcoRI fragment from 10 strains of R. fredii and broad-host-range Rhizobium sp. NGR234, hybridizing sequences are not detectable in other rhizobia.
Optimized Pulse Shaping for Intra-channel Nonlinearities Mitigation in a 10 Gbaud Dual-Polarization 16-QAM System (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. Châtelain, C. Laperle, K. Roberts, X. Xu, M. Chagnon, A. Borowiec, F. Gagnon, J. C. Cartledge, and D. V. Plant, "Optimized Pulse Shaping for Intra-channel Nonlinearities Mitigation in a 10 Gbaud Dual-Polarization 16-QAM System," in Optical Fiber Communication Conference/National Fiber Optic Engineers Conference 2011, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper OWO5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article