gebhart/patrepeval huggingface dataset:
A Reputation-Based Trust Mechanism for Ad Hoc Networks (2005)

The main characteristics of ad hoc networks are the lack of predefined infrastructure and the dynamic topology. These characteristics present some new security vulnerabilities for this emerging networking paradigm. Usually, security in ad hoc networks is handled through authentication and encryption. This can be considered as a first line of defense, however, this remain inefficient against some other kind of attacks such as malicious packet dropping. The purpose of this work is to provide a mechanism for detecting malicious incorrect packet forwarding attacks. To this end, a trust model extending routing protocols and based on the reputation concept is developed. Our model provides two main functionalities: monitoring the behavior of the neighboring nodes in the network and computing their reputations based on the information provided by the monitoring. This paper also discusses how the reputation information is gathered, stored and exchanged between the nodes, and computed according to the different scenarios. Our mechanism is also validated with some simulation work showing its feasibility, performance and benefits.
Bazooka is required for polarisation of the Drosophila anterior-posterior axis (2010)

The Drosophila anterior-posterior (AP) axis is determined by the polarisation of the stage 9 oocyte and the subsequent localisation of bicoid and oskar mRNAs to opposite poles of the cell. Oocyte polarity has been proposed to depend on the same PAR proteins that generate AP polarity in C. elegans, with a complex of Bazooka (Baz; Par-3), Par-6 and aPKC marking the anterior and lateral cortex, and Par-1 defining the posterior. The function of the Baz complex in oocyte polarity has remained unclear, however, because although baz-null mutants block oocyte determination, egg chambers that escape this early arrest usually develop normal polarity at stage 9. Here, we characterise a baz allele that produces a penetrant polarity phenotype at stage 9 without affecting oocyte determination, demonstrating that Baz is essential for axis formation. The dynamics of Baz, Par-6 and Par-1 localisation in the oocyte indicate that the axis is not polarised by a cortical contraction as in C. elegans, and instead suggest that repolarisation of the oocyte is triggered by posterior inactivation of aPKC or activation of Par-1. This initial asymmetry is then reinforced by mutual inhibition between the anterior Baz complex and posterior Par-1 and Lgl. Finally, we show that mutation of the aPKC phosphorylation site in Par-1 results in the uniform cortical localisation of Par-1 and the loss of cortical microtubules. Since non-phosphorylatable Par-1 is epistatic to uninhibitable Baz, Par-1 seems to function downstream of the other PAR proteins to polarize the oocyte microtubule cytoskeleton.
The Predictive Value of the Hemostasis Parameters in the Development of Preeclampsia (1992)

In order to find out which hemostasis parameters would have the predictive value for the development of preeclampsia, modified antithrombin III (ATM, representative of the antithrombin III-serine esterase complex), tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), beta-thromboglobulin (BTG), antithrombin III (AT III), fibrinogen, fibrin(ogen) degradation product (FDP), FDP D-dimer and euglobulin lysis time (ELT) were measured in 20 normal non-pregnant women, 21 normal pregnant women, 6 high-risk pregnant women, 14 preeclampsia pregnant women, and 5 patients with disseminated intravascular coagulation (DIC). Only tPA and AT III were found significantly different between the preeclampsia and the normal or high-risk pregnant women: tPA was found progressively and significantly increased from the normal pregnant, to the high-risk pregnant, then to the preeclampsia women (p less than 0.05). AT III was significantly lower in the preeclampsia than in the normal pregnant (p = 0.0001) or in the high-risk pregnant women (p = 0.002). In the 2nd trimester, tPA, PAI, fibrinogen and FDP were significantly higher, and AT III was significantly lower in the preeclampsia than in the normal pregnant women, whereas in the 3rd trimester, tPA and AT III were significantly higher or lower, respectively, in the preeclampsia than in the normal pregnant women. No significant difference of ATM could be found between the preeclampsia and the normal or high-risk pregnant women. From the present study, we suggest that tPA and AT III would be used as the main predictors, and FDP and D-dimer as the complementary predictors for the development of preeclampsia and should be detected in the normal or high-risk pregnant women.
Vortex drift. I: Dynamic interpretation (1993)

Vortical flow, restricted to a finite domain (in three dimensions) in an unbounded incompressible viscous fluid that is at rest at infinity, is investigated by the consideration of the dynamics in the potential flow region that surrounds the vortical domain. The evolution equations are considered for a flow that is given at an initial time t. The potential change in the far field is connected to the pressure, which in turn is expressed as the solution of a Poisson equation with sources distributed over the whole flow field. The leading term of the pressure at infinity is a quadrupole, which is caused by a drifting dipole field with a constant strength that is given by the impulse. This ‘‘dynamic’’ value of the drift is then identified with the classical ‘‘kinematic’’ definition as the speed of the impulse centroid. The main new result obtained by this method is the solution of the asymptotic drift problem in three dimensions, complementing the corresponding solution of Cantwell and Rott [Phys. Fluids 31, 3213 (1988)] for plane flow. The connection to the solution of the classical drift problem for a vortex ring is also established.
High molecular weight kininogen binds to Mac-1 on neutrophils by its heavy chain (domain 3) and its light chain (domain 5). (1994)

High molecular weight kininogen (HK) binds specifically, saturably, and reversibly to neutrophils and also reciprocally inhibits the binding of fibrinogen to neutrophils. Since fibrinogen binds to the leukocyte integrin CD11b/18 (Mac-1, alpha M beta 2), we investigated whether HK bound to Mac-1 and whether the binding site was similar to that for factor X. We also examined whether one or both chains of cleaved HK (HKa) were involved. Two monoclonal antibodies, 2B5 (0.29 microM) to HK heavy chain domains 2 (D2) and 3 (D3), and C11C1 (0.26 microM) to HK light chain domain 5 (D5), inhibited by 99 and 93% the binding, respectively, of 125I-HK (8.3 nM) to neutrophils. To minimize steric hindrance, we further demonstrated that the Fab' fragments of 2B5 and C11C1 were able to inhibit the binding of this ligand to virtually the same extent as the intact antibody, indicating that, as in binding of HK to platelets and endothelial cells, both chains are involved. To directly demonstrate the involvement of each chain, we showed that the reduced alkylated light chain derived from HK and low molecular weight kininogen, which contains the same heavy chain as HK, each markedly inhibited the binding of HK to neutrophils. We localized the domain responsible for the binding in each chain by showing that recombinant D3 and D5 decreased the binding of HK to neutrophils. To define the receptor for HK, we employed three monoclonal antibodies to Mac-1: OKM1 and OKM10 to epitopes on the alpha M subunit and IB4 to an epitope on the beta 2 chain. OKM1, which can inhibit fibrinogen binding to neutrophils, inhibited HK binding by 79%, whereas the other antibodies inhibited HK binding less than 25%. Coagulation factor X also binds to Mac-1 on monocytes at a similar site to C3bi. Synthetic peptides which define noncontiguous surface loops in factor X that interact with Mac-1, failed to inhibit 125I-HK binding to neutrophils. We conclude that HK binds, via domains on its heavy chain, D3, and light chain, D5, to Mac-1 on the neutrophil surface, and HK occupies a site overlapping with fibrinogen and different from factor X.
Impact of Particle Generation Method on the Apparent Hygroscopicity of Insoluble Mineral Particles (2010)

International audience
Articulated Human Detection with Flexible Mixtures of Parts (2012)

We describe a method for articulated human detection and human pose estimation in static images based on a new representation of deformable part models. Rather than modeling articulation using a family of warped (rotated and foreshortened) templates, we use a mixture of small, nonoriented parts. We describe a general, flexible mixture model that jointly captures spatial relations between part locations and co-occurrence relations between part mixtures, augmenting standard pictorial structure models that encode just spatial relations. Our models have several notable properties: 1) They efficiently model articulation by sharing computation across similar warps, 2) they efficiently model an exponentially large set of global mixtures through composition of local mixtures, and 3) they capture the dependency of global geometry on local appearance (parts look different at different locations). When relations are tree structured, our models can be efficiently optimized with dynamic programming. We learn all parameters, including local appearances, spatial relations, and co-occurrence relations (which encode local rigidity) with a structured SVM solver. Because our model is efficient enough to be used as a detector that searches over scales and image locations, we introduce novel criteria for evaluating pose estimation and human detection, both separately and jointly. We show that currently used evaluation criteria may conflate these two issues. Most previous approaches model limbs with rigid and articulated templates that are trained independently of each other, while we present an extensive diagnostic evaluation that suggests that flexible structure and joint training are crucial for strong performance. We present experimental results on standard benchmarks that suggest our approach is the state-of-the-art system for pose estimation, improving past work on the challenging Parse and Buffy datasets while being orders of magnitude faster.
Conversion of the Nikon C1 confocal laser-scanning head for multiphoton excitation on an upright microscope (2004)

Most commercial laser-scanning imaging systems used for confocal fluorescence microscopy can be readily adapted for use with two-photon fluorescence excitation. We report here on the details of the conversion of the Nikon C1 (product released November 2001) with two channels of nondescanned detection of two-photon-excited fluorescence. One of the goals of the design was to utilize off-the-shelf components as much as possible to minimize the use of custom machining and electronics assembly. We also give some initial characterization of the imaging properties of the system.
Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas (2007)

Mounting evidence suggests that dynamic interactions between a tumor and its microenvironment play a critical role in tumor development, cell-cycle progression, and response to therapy. In this study, we used mantle cell lymphoma (MCL) as a model to characterize the mechanisms by which stroma regulate cell-cycle progression. We demonstrated that adhesion of MCL and other non-Hodgkin lymphoma (NHL) cells to bone marrow stromal cells resulted in a reversible G(1) arrest associated with elevated p27(Kip1) and p21 (WAF1) proteins. The adhesion-mediated p27(Kip1) and p21 increases were posttranslationally regulated via the down-regulation of Skp2, a subunit of SCF(Skp2) ubiquitin ligase. Overexpression of Skp2 in MCL decreased p27(Kip1), whereas inhibition of Skp2 by siRNA increased p27(Kip1) and p21 levels. Furthermore, we found cell adhesion up-regulated Cdh1 (an activating subunit of anaphase-promoting complex [APC] ubiquitin ligase), and reduction of Cdh1 by siRNA induced Skp2 accumulation and hence p27(Kip1) degradation, thus implicating Cdh1 as an upstream effector of the Skp2/p27(Kip1) signaling pathway. Overall, this report, for the first time, demonstrates that cell-cell contact controls the tumor cell cycle via ubiquitin-proteasome proteolytic pathways in MCL and other NHLs. The understanding of this novel molecular pathway may prove valuable in designing new therapeutic approaches for modifying tumor cell growth and response to therapy.
RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α (2009)

Hypoxia-inducible factors (HIFs) are critical transcription factors that mediate cell survival during reduced oxygen conditions (hypoxia). At regular oxygen conditions (normoxia), HIF-1alpha and HIF-2alpha are continuously synthesized in cells and degraded via the ubiquitin-proteasome pathway. During hypoxia, these proteins are stabilized and translocate to the nucleus to activate transcription of target genes that enable cell survival at reduced oxygen levels. HIF proteins are tightly regulated via post-translational modifications including phosphorylation, acetylation, prolyl-hydroxylation and ubiquitination. Here we show for the first time that exogenous and endogenous HIF-2alpha are also regulated via the ubiquitin-like modifier small ubiquitin-like modifiers (SUMO). Using mutational analysis, we found that K394, which is situated in the sumoylation consensus site LKEE, is the major SUMO acceptor site in HIF-2alpha. Functionally, sumoylation reduced the transcriptional activity of HIF-2alpha. Similar to HIF-1alpha, HIF-2alpha is regulated by the SUMO protease SENP1. The proteasome inhibitor MG132 strongly stabilized SUMO-2-conjugated HIF-2alpha during hypoxia but did not affect the total level of HIF-2alpha. The ubiquitin E3 ligases von Hippel-Lindau and RNF4 control the levels of sumoylated HIF-2alpha, indicating that sumoylated HIF-2alpha is degraded via SUMO-targeted ubiquitin ligases.
Investigation of Factors Affecting Iced-Airfoil Aerodynamics (2003)

A summary of the effects the ice-accretion geometry, size, and location; the airfoil geometry; and the e ight Reynolds number on iced-airfoil aerodynamics, based on the e ndings of the recent University of Illinois investigations,ispresented.Fourairfoilsweretestedwithsimulatedglaze-icehornandspanwiseridgeice.Increasing theiceshapeheightgenerally resultedin moresevereperformancedegradation.Theexceptionwaswhentheiceshapewas locatedattheleadingedgeoftheairfoil,whereincreasedice-shapeheightdidnotsignie cantlydegradeperformance. Varying the leading-edge radius of glaze-icehorn did not have a large effect on airfoil performance. The variations in the geometry of the simulated ridge ice had some effect on airfoil aerodynamics, with (of the shapes tested ) the half-round shape having a signie cantly higher maximum lift. Iced-airfoil aerodynamics were relatively insensitive to Reynolds number variations. Large differences in iced-airfoil aerodynamics were observed between different airfoil geometries. The e ndings showed that an airfoil’ s sensitivity to ridge-ice accretions (which usually forms between 10 and 20% chord )was largely dependent on its load distribution. The airfoil that was very front-loaded, with large leading-edge suction, had the most severe performance degradation due to this type of ice accretion.
Pyridonecarboxylic acids as antibacterial agents. Part XIII. Regioselective displacement reactions of 1-cyclopropyl-5,6,7,8-tetrafluoro-4(1H)-oxoquinoline-3-carboxylic acid with amine nucleophiles. (1990)

The displacement reactions of ethyl 1-cyclopropyl-5, 6, 7, 8-tetrafluoro-4(1H)-oxoquinoline-3-carboxylate (7) and its carboxylic acid 8 with amine nucleophiles were examined. The nucleophilic displacement occurred regioselectively at the C-5 or C-7 position depending on the substrate (7 or 8) and solvent selected; this finding permitted the introduction of an optional nucleophile preferentially into the required position at either C-5 or C-7, or into both positions with a desired combination of nucleophiles. Taking advantage of this regioselectivity, we prepared various 5-substituted 6, 7, 8-trifluoro- and 7-substituted 5, 6, 8-trifluoro-1-cyclopropyl-4(1H)-oxoquinoline-3-carboxylic acids. Furthermore, the use of the boron-chelated derivative of the carboxylic acid 8 was favorable for the regioselective synthesis of 7-substituted 5, 6, 8-trifluoroquinolones.
Mobile authentication of copy detection patterns (2023)

In the recent years, the copy detection patterns (CDP) attracted a lot of attention as a link between the physical and digital worlds, which is of great interest for the internet of things and brand protection applications. However, the security of CDP in terms of their reproducibility by unauthorized parties or clonability remains largely unexplored. In this respect, this paper addresses a problem of anti-counterfeiting of physical objects and aims at investigating the authentication aspects and the resistances to illegal copying of the modern CDP from machine learning perspectives. A special attention is paid to a reliable authentication under the real-life verification conditions when the codes are printed on an industrial printer and enrolled via modern mobile phones under regular light conditions. The theoretical and empirical investigation of authentication aspects of CDP is performed with respect to four types of copy fakes from the point of view of (i) multi-class supervised classification as a baseline approach and (ii) one-class classification as a real-life application case. The obtained results show that the modern machine-learning approaches and the technical capacities of modern mobile phones allow to reliably authenticate CDP on end-user mobile phones under the considered classes of fakes.
Heat and Moisture Transport Through a Glass-Fiber Slab with One Side Subject to a Freezing Temperature (1991)

Experiments were performed of heat and moisture transport through a glass-fiber slab to investigate the effect of condensation and frosting on the thermal performance of insulation. The slab has one side impermeable and subject to a cold temperature (below the triple point of water) and the other side open to a moist air at a room temperature and for various humidity levels. The accumulation of moisture and frost results in an increase in heat loss up to a maximum of twice as much as that for a dry insulation. A comparison between a one-dimensional, numerical model based on a formulation of vapor diffusion in porous media and the experimental results, reveals that significant hygroscopic effects occur in the experiment for initially oven-dried specimens, and contribute to the discrepancy between the transient results of the prediction and of the experiments. For the transient processes, the differences in predictions, excluding the adsorption phenomenon, and the experimental data can lead to a maximum discrepancy of 26% in temperature and of 35% in heat flux.
Joint Scale-Lag Diversity in Mobile Wideband Communications (2005)

We consider the effect of mobility on a wideband direct sequence spread spectrum (DSSS) communication system, and study a scale-lag Rake receiver capable of leveraging the diversity that results from mobility. A wideband signal has a large bandwidth-to-center frequency ratio, such that the typical narrowband Doppler spread assump-tions do not apply to mobile channels. Instead, we assume a more general temporal scaling phenomenon, i.e., a dilation of the transmitted signal’s time support. Based on a uniform ring of scatterers model, we determine that the wideband scattering function, which quantifies the average scale spreading, has a “bathtub-shaped” scale profile. We investigate, through frame-theoretic tools, the translation- and dilation-spacing parameters of a scale-lag Rake basis, and compare the performances of a scale-lag Rake and a Doppler-lag Rake, each capable of leveraging the diversity that results from mobility. When the translation spacing of the Rake functions is equal to the minimum resolvable lag, there is no significant performance difference between the receivers. For wider spacings, the receiver is more reliant on dilation diversity; hence, the scale-lag Rake receiver performs relatively better. Such analysis applies, for example, to ultra-wideband (UWB) radio frequency channels and underwater wideband acoustic channels. We study the correlation structure of the scale-lag Rake fingers and show that the normalized scale spread parameter relates directly to the time-variability of the ii channel. We discover that much of the channel energy is concentrated in few eigenmodes and hence propose principal components combining for a reduced-complexity solution. Finally, we perform physical experiments in the air-acoustic channel to demonstrate the applicability of the wideband channel model.
High-Rate Full-Diversity Space–Time–Frequency Codes for Broadband MIMO Block-Fading Channels (2007)

A systematic design of high-rate full-diversity space-time-frequency (STF) codes is proposed for multiple-input multiple-output frequency-selective block-fading channels. It is shown that the proposed STF codes can achieve rate M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> and full-diversity M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</sub> L, i.e., the product of the number of transmit antennas M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> , receive antennas M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> , fading blocks M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</sub> , and channel taps L. The proposed STF codes are constructed from a layered algebraic design, where each layer of algebraic coded symbols are parsed into different transmit antennas, orthogonal frequency-division multiplexing tones, and fading blocks without rate loss. Simulation results show that the proposed STF codes achieve higher diversity gain in block-fading channels than some typical space-frequency codes
Management of Atrial Fibrillation in COVID-19 Pandemic (2020)

The health crisis due to coronavirus disease 2019 (COVID-19) has shocked the world, with more than 1 million infections and casualties. COVID-19 can present from mild illness to multi-organ involvement, but especially acute respiratory distress syndrome. Cardiac injury and arrhythmias, including atrial fibrillation (AF), are not uncommon in COVID-19. COVID-19 is highly contagious, and therapy against the virus remains premature and largely unknown, which makes the management of AF patients during the pandemic particularly challenging. We describe a possible pathophysiological link between COVID-19 and AF, and therapeutic considerations for AF patients during this pandemic.