gebhart/patrepeval huggingface dataset:
Allergenicity of Bos d 5 in Children with Cow's Milk Allergy is Reduced by Transglutaminase Polymerization (2011)

<b><i>Background:</i></b> Cow's milk allergy in pediatric patients is an unresolved issue. Among the proteins in milk, bovine whey beta-lactoglobulin (Bos d 5) is the most commonly allergenic. Allergenicity to native cow's milk proteins in humans is a well-studied issue, but very little is known about the allergenicity of cross-linked proteins found in bioprocessed dairy products. <b><i>Objective:</i></b> The objective of this study was to evaluate the allergenicity of polymerized bovine whey beta-lactoglobulin in symptomatic children diagnosed with IgE-mediated Bos d 5 hypersensitivity. <b><i>Methods:</i></b> Side-by-side skin prick tests with native and polymerized bovine whey beta-lactoglobulin were performed in 22 symptomatic children allergic to cow's milk with detectable specific IgE to Bos d 5 by CAP Systems Pharmacia. A matched control group tolerant to cow's milk and undetectable specific IgE to Bos d 5 was established for comparison. Wheal mean diameter was compared between the native and polymerized groups by paired <i>t</i>-tests. <b><i>Results:</i></b> The mean difference in wheal mean diameter observed between native versus polymerized bovine whey beta-lactoglobulin in the paired skin prick test of the allergic group was 2.27 mm (<i>p</i>=0.02; 95% CI 0.38-4.16). <b><i>Conclusions:</i></b> The skin prick test showed a significant reduction in the allergenicity of polymerized compared with native bovine whey beta-lactoglobulin in children with IgE-mediated Bos d 5 hypersensitivity.
Reorganizing the System of Care Surrounding Laparoscopic Surgery: A Cost-Effectiveness Analysis Using Discrete-Event Simulation (2004)

The proposed system is more cost-effective relative to current practice over a wide range of mortality rates, hand-off times, and scheduled patient volumes.
The Wearable Defibrillator as a Bridge to Reimplantation in Patients with ICD or CRT-D Infections (2016)

Objectives: The approach to treat device infection in patients with implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D) is a challenging procedure. Optimal treatment is a complete extraction of the infected device. Therefore, we investigated the management and outcome of patients with ICD or CRT-D infections using the wearable defibrillator (WD) as a bridge to re-implantation after lead extraction procedures.
Yüksek Işınlıklı Büyük Hadron Çarpıştırıcısında Uyarılmış Kuarkın Rezonans Üretimi (2022)

Bu çalışmada etkileşim Lagranjiyen yöntemi kullanılarak, dejenere durumdaki uyarılmış kuarkların Yüksek Işınlıklı Büyük Hadron Çarpıştırıcısında (YI-BHÇ) rezonans üretimleri incelenmiştir. YI-BHÇ’de rezonans da üretilen uyarılmış kuarkların iki-jet son durumuna sahip olduğu sinyal kanalı için hesaplamalar yapılmıştır. Uyarılmış kuark sinyalini ardalandan ayırt edecek sınırlandırmaları belirlemek için sinyal ardalan analizi yapılmıştır. Bu analiz vasıtasıyla belirlenen sınırlandırmalar kullanılarak YI-BHÇ’de uyarılmış kuarkın kütlesi için keşif, gözlem ve dışarlama limitleri hesaplanmıştır. Ayrıca uyarılmış kuark için kompozitlik ölçeği taraması yapılarak, farklı kütle değerleri için ulaşabileceği en üst kompozitlik ölçeği değerleri hesaplanmıştır. Son olarak 1’den küçük serbest parametre değerlerinde dahi uyarılmış kuarkın YI-BHÇ’de keşif edilebileceği gösterilmiştir. Tüm bu hesaplamaların sonucunda, YI-BHÇ’nin uyarılmış kuarkları araştırmada çok iyi bir potansiyele sahip olacağı ortaya çıkmıştır.
Down‐regulation of amygdala preprotachykinin A mRNA but not3H‐SP receptor binding sites in subjects affected by mood disorders and schizophrenia (2005)

Increasing evidence suggests that substance P (SP) neurokinin-1 (NK1) receptors are involved in stress and emotional responses, representing a potential target for the treatment of anxiety and depression in humans. Given the important role of the amygdaloid complex in the regulation of emotional behavior, we examined the mRNA levels of preprotachykinin A [PPT-A, a precursor of both SP and neurokinin A (NKA)] and 3H-SP binding sites in the amygdala of patients affected by bipolar disorder, major depression or schizophrenia as compared with matched control individuals. By means of in situ hybridization, a significant reduction of PPT-A mRNA expression levels was detected in the three diagnostic groups, mainly in the basal, lateral and accessory basal amygdaloid nuclei, but not in the temporal cortical area proximal to the amygdala. Receptor autoradiography performed on adjacent sections showed no change in 3H-SP binding sites as compared with controls. No significant correlation was found between levels of PPT-A mRNA expression or binding sites and subject age, gender, hemisphere side, cause of death or history of substance misuse (marijuana, alcohol, cocaine/amphetamine). An inverse relationship between PPT-A mRNA expression levels and lifetime antipsychotic treatment (Fluphenazine) in the schizophrenic and bipolar disorder groups was found. Post-mortem delay was also negatively correlated with NK1 binding sites. The results confirm an involvement of the tachykinins in psychiatric disorders, suggesting there is a generalized impairment of the SP system in the amygdala in mood disorders and schizophrenia rather than this being a disease-related phenomenon.
A semantic-mediation architecture for interoperable supply-chain applications (2009)

This paper presents a semantic-mediation architecture that enables standards-based interoperability between heterogeneous supply-chain applications. The architecture was implemented using a state-of-the-art semantic-mediation toolset for design-time and run-time integration tasks. The design-time tools supported a domain ontology definition, message annotations, message schema transformations and reconciliation rules specifications. The run-time tools performed exchanges, transformations, and reconciliations of the messages. The architecture supports a supply-chain integration scenario where heterogeneous automotive manufacturing supply-chain applications exchange inventory information.
Compliant actuation based on dielectric elastomers for a force-feedback device: modeling and experimental evaluation (2012)

Thanks to their large power densities, low costs and shock-insensitivity, Dielectric Elastomers (DE) seem to be a promising technology for the implementation of light and compact force-feedback devices such as, for instance, haptic interfaces. Nonetheless, the development of these kinds of DE-based systems is not trivial owing to the relevant dissipative phenomena that affect the DE when subjected to rapidly changing deformations. In this context, the present paper addresses the development of a force feedback controller for an agonist-antagonist linear actuator composed of a couple of conically-shaped DE films and a compliant mechanism behaving as a negative-rate bias spring. The actuator is firstly modeled accounting for the viscohyperelastic nature of the DE material. The model is then linearized and employed for the design of a force controller. The controller employs a position sensor, which determines the actuator configuration, and a force sensor, which measures the interaction force that the actuator exchanges with the environment. In addition, an optimum full-state observer is also implemented, which enables both accurate estimation of the time-dependent behavior of the elastomeric material and adequate suppression of the sensor measurement noise. Preliminary experimental results are provided to validate the proposed actuator-controller architecture&nbsp;
<title>Launch vehicle payload adapter design with vibration isolation features</title> (2005)

Payloads, such as satellites or spacecraft, which are mounted on launch vehicles, are subject to severe vibrations during flight. These vibrations are induced by multiple sources that occur between liftoff and the instant of final separation from the launch vehicle. A direct result of the severe vibrations is that fatigue damage and failure can be incurred by sensitive payload components. For this reason a payload adapter has been designed with special emphasis on its vibration isolation characteristics. The design consists of an annular plate that has top and bottom face sheets separated by radial ribs and close-out rings. These components are manufactured from graphite epoxy composites to ensure a high stiffness to weight ratio. The design is tuned to keep the frequency of the axial mode of vibration of the payload on the flexibility of the adapter to a low value. This is the main strategy adopted for isolating the payload from damaging vibrations in the intermediate to higher frequency range (45Hz-200Hz). A design challenge for this type of adapter is to keep the pitch frequency of the payload above a critical value in order to avoid dynamic interactions with the launch vehicle control system. This high frequency requirement conflicts with the low axial mode frequency requirement and this problem is overcome by innovative tuning of the directional stiffnesses of the composite parts. A second design strategy that is utilized to achieve good isolation characteristics is the use of constrained layer damping. This feature is particularly effective at keeping the responses to a minimum for one of the most important dynamic loading mechanisms. This mechanism consists of the almost-tonal vibratory load associated with the resonant burn condition present in any stage powered by a solid rocket motor. The frequency of such a load typically falls in the 45-75Hz range and this phenomenon drives the low frequency design of the adapter. Detailed finite element analysis is used throughout to qualify the design for vibration isolation performance as well as confirm its static and dynamic strength.
Co-suspension delivery technology in pressurized metered-dose inhalers for multi-drug dosing in the treatment of respiratory diseases (2017)

Technologies for long-term delivery of aerosol medications in asthma and chronic obstructive pulmonary disease have improved over the past 2 decades with advancements in our understanding of the physical chemistry of aerosol formulations, device engineering, aerosol physics, and pulmonary biology. However, substantial challenges remain when a patient is required to use multiple inhaler types, multiple medications, and/or combinations of medications. Combining multiple drugs into a single inhaler while retaining appropriate dosing of the individual agents in the combination may enhance patient adherence to therapy and reduce device errors that occur when patients are using multiple inhalers. Pressurized metered-dose inhaler (pMDI) devices are widely used by patients for acute symptom relief as well as maintenance treatment, so the pMDI may be a suitable option with which to explore medication combinations. However, optimizing drug formulation remains a key challenge for pMDI delivery systems. This article introduces a new pMDI formulation approach: co-suspension delivery technology, which uses drug crystals with porous, low-density phospholipid particles engineered to deliver combinations of drugs to the airways with accurate and consistent dosing via pMDIs, independent of medication types and combinations. We describe the key characteristics of pMDIs, and discuss the rationale for the co-suspension delivery technology platform based on the limitations associated with traditional formulations. Finally, we discuss the clinical implications of co-suspension delivery technology for developing combination drug therapies administered by pMDIs.
IVF in Practice (1988)

At the time of writing (early 1988) the number of clinics practising IVF in the U.K. is approaching 40. No two clinics operate in the same manner so that what follows is a general account of the procedures involved. Six stages may be listed (figure 4.1):
Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology (2007)

Artermisinin and its derivatives are now the mainstays of antimalarial treatment; however, their mechanism of action is only poorly understood. We report on the synthesis of a novel series of epoxy-endoperoxides that can be prepared in high yields from simple starting materials. Endoperoxides that are disubstituted with alkyl or benzyl side chains show efficient inhibition of the growth of both chloroquine-sensitive and -resistant strains of Plasmodium falciparum. A trans-epoxide with respect to the peroxide linkage increases the activity compared to that of its cis-epoxy counterpart or the parent endoperoxide. The novel endoperoxides do not show a strong interaction with artemisinin. We have compared the mechanism of action of the novel endoperoxides with that of artemisinin. Electron microscopy reveals that the novel endoperoxides cause the early accumulation of endocytic vesicles, while artemisinin causes the disruption of the digestive vacuole membrane. At longer incubation times artemisinin causes extensive loss of organellar structures, while the novel endoperoxides cause myelin body formation as well as the accumulation of endocytic vesicles. An early event following endoperoxide treatment is the redistribution of the pH-sensitive probe LysoSensor Blue from the digestive vacuole to punctate structures. By contrast, neither artemisinin nor the novel endoperoxides caused alterations in the morphology of the endoplasmic reticulum nor showed antagonistic antimalarial activity when they were used with thapsigargin. Analysis of rhodamine 123 uptake by P. falciparum suggests that disruption of the mitochondrial membrane potential occurs as a downstream effect rather than as an initiator of parasite killing. The data suggest that the digestive vacuole is an important initial site of endoperoxide antimalarial activity.
The impact of low concentrations of aflatoxin, deoxynivalenol or fumonisin in diets on growing pigs and poultry (2003)

In the present review, the quantitative impact of dietary aflatoxin, deoxynivalenol (DON) and fumonisin concentrations on performance of pigs and broilers is evaluated, with special emphasis on low concentrations of these toxins. Also, responses in performance of pigs and broilers to these three toxins are related to their absorption and elimination kinetics. By applying simple linear regression, information from many literature sources is integrated and condensed into, for example, estimates of depression in rates of weight gain, relative to non-contaminated diets, with increasing toxin concentrations. It was estimated that with each mg/kg increase of aflatoxin in the diet, the growth rate would be depressed by 16 % for pigs and 5 % for broilers. For DON, with each mg/kg increase in the diet, the growth depression was estimated at about 8 % for pigs, while broilers showed no response to DON concentrations below 16 mg/kg. Fumonisin showed the lowest impact on growth performance; with each mg/kg increase, the depression in growth rate was estimated at 0.4 and 0.0 % for pigs and broilers, respectively. Dietary concentrations that cause a 5 % reduction in growth rate were estimated at 0.3 and 1.0 mg/kg for aflatoxin for pigs and broilers, respectively; 1.8 and 0.6 mg/kg for pure and naturally contaminated DON for pigs, respectively; 21 and 251 mg/kg for fumonisin for pigs and broilers, respectively.
A Dynamic Program for a Team of Two Agents with Nested Information (2021)

In this paper, we investigate a sequential dynamic team problem consisting of two agents with a nested information structure. We use a combination of the person-by-person and prescription approach to derive structural results for optimal control strategies for the team. We then use these structural results to present a dynamic programming (DP) decomposition to derive the optimal control strategies for a finite time horizon. We show that our DP utilizes the nested information structure to simplify the computation of the optimal control laws for the team at the final time step.
A VLSI implementation of a SMDS attachment unit over an ICI interface (2002)

The UNICORN project interconnects an Ethernet LAN with a MAN, a SMDS (Switched Multi-megabit Data Service) network, through a B-ISDN network based on SDH and ATM. In the realization of this project, three ASICs have been conceived, one for SDH, one for ATM, and the one presented in this paper, the MPC (MAN Protocol Controller) ASIC. We present the implementation of the ICIP (Inter-Carrier Interface Protocol) protocol on the MPC ASIC. This protocol is used over an ICI (Inter-Carrier Interface) interface to communicate with a SMDS network on a point-to-point basis. The MPC ASIC is used in the ICIP Network Adaptation Unit, a VME64 Double-Height board that can be integrated in the VME Bus to interconnect with the B-ISDN Internetwork Unit and the rest of the UNICORN project.
Melt‐Polymerization of TEMPO Methacrylates with Nano Carbons Enables Superior Battery Materials (2015)

A solvent-free, melt polymerization process of a 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) precursor for rechargeable organic radical batteries is proposed. In situ carbon incorporation in the melted monomer phase yields a nanoscale homogenous polymer composite. Superior battery performances including higher power and cycling stability are attained by using the melt-polymerization method.
Measurements of OH, H2SO4, and MSA during Tropospheric Ozone Production About the Spring Equinox (TOPSE) (2003)

Data from OH, H 2 SO 4 , and MSA measurements performed during Tropospheric Ozone Production About the Spring Equinox (TOPSE) are presented. Model simulations of OH results made at solar zenith angles of 60° or less showed a tendency of the model to overestimate OH concentrations. This overestimation was a factor of 1.7 at the lower latitudes (&lt;57°N) of the study. At higher latitudes (&gt;57°N) the model tended toward agreement and ultimately an underestimation of OH concentrations by a factor of 0.7. Comparisons of measurements and model showed the model underestimates OH concentrations at solar zenith angles greater than 70°. The results of the present study are discussed in the context of previous studies. Possible model discrepancies are discussed. Measurements of H 2 SO 4 showed the highest concentrations at the lowest altitudes (&lt;2000 m) and the lowest latitudes of the study. Larger H 2 SO 4 concentrations observed at higher latitudes were accompanied at times by particle nucleation as indicated by the presence of UCN (ultra‐fine condensation nuclei) with diameters of 3–4 nm. Concentrations of MSA were generally low with typical values of &lt;2 × 10 5 molecule cm −3 . High concentrations (&gt;10 7 molecule cm −3 ) were found in layers and were accompanied by other compounds such as NO x and NO y indicating MSA may also have an industrial source.
Hitting Times of Some Critical Events in RNA Origins of Life (2021)

Can a replicase be found in the vast sequence space by random drift? We partially answer this question through a proof-of-concept study of the times of occurrence (hitting times) of some critical events in the origins of life for low-dimensional RNA sequences using a mathematical model and stochastic simulation studies from Python software. We parameterize fitness and similarity landscapes for polymerases and study a replicating population of sequences (randomly) participating in template-directed polymerization. Under the ansatz of localization where sequence proximity correlates with spatial proximity of sequences, we find that, for a replicating population of sequences, the hitting and establishment of a high-fidelity replicator depends critically on the polymerase fitness and sequence (spatial) similarity landscapes and on sequence dimension. Probability of hitting is dominated by landscape curvature, whereas hitting time is dominated by sequence dimension. Surface chemistries, compartmentalization, and decay increase hitting times. Compartmentalization by vesicles reveals a trade-off between vesicle formation rate and replicative mass, suggesting that compartmentalization is necessary to ensure sufficient concentration of precursors. Metabolism is thought to be necessary to replication by supplying precursors of nucleobase synthesis. We suggest that the dynamics of the search for a high-fidelity replicase evolved mostly during the final period and, upon hitting, would have been followed by genomic adaptation of genes and to compartmentalization and metabolism, effecting degree-of-freedom gains of replication channel control over domain and state to ensure the fidelity and safe operations of the primordial genetic communication system of life.
An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics (2023)

This study describes the cell-free biomanufacturing of a broad-spectrum antiviral protein, griffithsin (GRFT) such that it can be produced in microgram quantities with consistent purity and potency in less than 24 h. We demonstrate GRFT production using two independent cell-free systems, one plant and one microbial. Griffithsin purity and quality were verified using standard regulatory metrics. Efficacy was demonstrated in vitro against SARS-CoV-2 and HIV-1 and was nearly identical to that of GRFT expressed in vivo. The proposed production process is efficient and can be readily scaled up and deployed wherever a viral pathogen might emerge. The current emergence of viral variants of SARS-CoV-2 has resulted in frequent updating of existing vaccines and loss of efficacy for front-line monoclonal antibody therapies. Proteins such as GRFT with its efficacious and broad virus neutralizing capability provide a compelling pandemic mitigation strategy to promptly suppress viral emergence at the source of an outbreak.
L1-Regularization Path Algorithm for Generalized Linear Models (2007)

Summary We introduce a path following algorithm for L1-regularized generalized linear models. The L1-regularization procedure is useful especially because it, in effect, selects variables according to the amount of penalization on the L1-norm of the coefficients, in a manner that is less greedy than forward selection–backward deletion. The generalized linear model path algorithm efficiently computes solutions along the entire regularization path by using the predictor–corrector method of convex optimization. Selecting the step length of the regularization parameter is critical in controlling the overall accuracy of the paths; we suggest intuitive and flexible strategies for choosing appropriate values. We demonstrate the implementation with several simulated and real data sets.
OPTICAL PROPERTIES OF LiNbO_3 IMPLANTED BY Ti ION (1992)

Surface optical properties of x,y,z cut LiNbO_3 single crystal specimen im-planted by 350 keV high energy Ti ions(implantation dose is 1.5x10~(17)/cm~2)were studied inthis paper.Exeperiments about transmission and refractive index of x,y,z cut implantedLiNbO_3 specimen treated by high temperature annealing were carried out.Light loss caused byion implantation can be reduced by thermal annealing.Refractive index of implanted layer canbe increased by 11—13%.
Optical Resolution of (±)-Fenfluramine and (±)-Norfenfluramine by Preferential Crystallization (1988)

Abstract Five salts of (±)-fenfluramine (F) and three salts of (±)-norfenfluramine (N) have been identified as being conglomerates. Six of these salts could be resolved by preferential crystallization.