gebhart/patrepeval huggingface dataset:
CHRONIC DECREASE IN FLOW CONTRIBUTES TO HEART FAILURE‐INDUCED ENDOTHELIAL DYSFUNCTION IN RATS (2004)

Chronic heart failure (CHF) impairs endothelium-dependent, nitric oxide (NO)-mediated dilation. This decreased dilation may be partly secondary to the chronic decrease in blood flow, but this hypothesis has not yet been tested. Thus, we assessed whether a localized, chronic increase in blood flow in vivo reverses endothelial dysfunction of small arteries in rats with CHF. Two months after coronary artery ligation or sham surgery, second-order side branches of the superior mesenteric artery were ligated in order to obtain persistently elevated blood flow (HF) in the adjacent first-order side branch compared with normal vessels (NF). One month later, responses to acetylcholine and flow-mediated vasodilatation (FMD) were assessed in vitro in an arteriograph. Chronic heart failure induced a decrease in mesenteric blood flow (374 +/- 25 and 305 +/- 27 micro L/min for sham and CHF, respectively; P < 0.05). Neither CHF nor the chronic increase in flow affected the responses to acetylcholine. Chronic heart failure decreased FMD (maximal response in sham and control 34 +/- 6 and 13 +/- 4%, respectively; P < 0.05). Chronic increases in blood flow did not modify FMD in sham, but restored FMD in CHF rats (28 +/- 4%; P < 0.05 vs CHF NF). The restored response was abolished by an inhibitor of NO synthesis (N(G)-nitro-l-arginine). Chronic heart failure did not affect the abundance of mesenteric endothelial NO synthase (eNOS) mRNA. A chronic increase in flow significantly increased the abundance of eNOS mRNA in sham rats, but only moderately and non-significantly in CHF rats. Thus, endothelial dysfunction of small arteries in CHF appears to be largely the consequence of the chronic decrease in flow.
A Biomechanical Study to Evaluate the Effect of PMMA Augmentation and Restoration of the Strength of Cervical Vertebral Screws Inserted in an Osteoporotic Vertebral Body (2014)

The results indicated that both PMMA augmentation and PMMA restoration could significantly increase cervical screw pull-out strength and antifatigue capability. The results provide a biomechanical justification for spine surgeons to use PMMA for augmentation or restoration in cases of surgeries with poor bone quality or osteoporotic vertebral bodies.
An Exceptionally Selective Lead( II )‐Regulatory Protein from Ralstonia Metallidurans : Development of a Fluorescent Lead( II ) Probe (2005)

Lighting up lead: A Pb2+-regulatory protein from Ralstonia metallidurans has been converted into a highly sensitive fluorescent Pb2+ probe (PbR691, turquoise circles in scheme). This fluorescent system reveals that the protein exhibits a surprisingly high binding selectivity towards Pb2+ ions over other metal ions. Supporting Information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462443_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
International trends in admissions and drug sales for asthma. (2006)

At the national level, there is good evidence that over the last decade, increased sales of asthma drugs, and ICS in particular, were associated with a decline in rates of hospital admission for asthma. This is consistent with a beneficial effect of increasing use of asthma drugs, but other explanations such as decreasing prevalence could also be responsible.
Mechanical stretch induces lung α-epithelial Na+channel expression (2014)

ABSTRACT During fetal development physiological stretching helps drive lung growth and maturation. At birth, the α-subunit of the alveolar epithelial sodium channel (α-ENaC) is a critical factor in helping to facilitate clearance of lung fluid during the perinatal period. The effects of stretch, however, on α-ENaC expression in the fetal lung have yet to be elucidated. In an effort to explore this question, we used both an in vitro cell culture model that exposes cells to repetitive cyclic stretch (CS) as well as an in vivo preterm animal model of mechanical ventilation (MV). We found that murine lung epithelial (MLE-12) cells exposed to repetitive CS showed a significant rise in α-ENaC mRNA expression. Total and cell-surface protein abundance of α-ENaC were also elevated after 24 h of CS. Stretch-induced increases in α-ENaC expression were suppressed in the presence of either actinomycin D or cycloheximide. Pharmacological inhibition of the extracellular signal-regulated protein kinase (ERK1/2) did not attenuate stretch-induced increases in α-ENaC protein, whereas inhibition of p38 MAPK or c-Jun NH2-terminal kinase (JNK) did. In 29-day preterm rabbits, alveolar stretching secondary to postnatal MV markedly elevated fetal lung α-ENaC expression compared to spontaneously breathing counterparts. In summary, our findings indicate that mechanical stretch promotes α-ENaC expression.
The effects of compressible and incompressible states on the FIR-absorption of quantum wires and dots in a magnetic field (1997)

We investigate the effects of compressible and incompressible states on the FIR-absorption of quantum wires and dots in a homogeneous perpendicular magnetic field. The electron-electron interaction is treated in the Hartree approximation at a finite low temperature. The calculated dispersion of the collective excitations reproduces several experimental results.
Measurement of Surface Interfacial Tension as a Function of Temperature Using Pendant Drop Images (2011)

Accurate and reliable measurements of surface tension at the interface of immiscible phases are crucial to understanding various physico-chemical reactions taking place between those. Based on the pendant drop method, an optical (graphical)-numerical procedure was developed to determine surface tension and its dependency on the surrounding temperature. For modeling and experimental verification, chemically inert and thermally stable perfluorocarbon (PFC) oil and water was used. Starting with geometrical force balance, governing equations were derived to provide non-dimensional parameters which were later used to extract values for surface tension. Comparative study verified the accuracy and reliability of the proposed method.
Biochemical characterization of putative subviral particulates from human malignant breast tumors. (1975)

Particulates with the properties of cores and/or ribonucleoproteins of RNA tumor viruses have been isolated from Sterox-SL-treated fractions of murine and human mammary adenocarcinomas. These particulates have an RNA-directed DNA polymerase, a 60 to 70 S RNA, and a density of 1.26 g/ml or greater in sucrose equilibrium density gradients. Their uniquely higher densities lead to banding in regions comparatively free of cellular contaminants. These circumstances minimize some of the technical complications of performing the simultaneous detection assay in the presence of cell debris.
Infectious Chocolate Joy with a Side of Poissonian Statistics: An activity connecting life science students with subtle physics concepts (2015)

Introductory physics courses are required for many programs in the life sciences, yet traditional curricula fail to help students meaningfully connect physical concepts with biological systems.&nbsp; In this lesson, we describe an activity taught in a large introductory physics class designed for life science majors (n = 143; 80% premedical students). The lesson was integrated in a novel curriculum focusing on a quantitative approach to biological topics.&nbsp; Students often hold the misconception that biological processes always happen in a uniform manner.&nbsp; This activity uses the biological example of a human immunodeficiency virus (HIV) infecting T lymphocytes (T cells) to motivate understanding of the macroscopic distribution of HIV in T cells, a non-uniform, Poisson distribution.&nbsp; In the spirit of scientific teaching and scientific inquiry, the lesson begins with students making a prediction and then testing it with a deceptively simple hands-on simulation that uses chocolate candy as a proxy for HIV and plastic Easter eggs to play the role of T cells. The lesson requires groups of students to collect, analyze, and interpret data from this simulation. Students then enter into an open-ended discussion on the validity of modeling different events as a Poisson distribution. Our observations and student feedback indicate that this lesson stood out as one of the most engaging and memorable activities during the semester.&nbsp; Students were able to recognize and apply the definition of a Poisson distribution to given examples as well as in future assignments and exams.&nbsp;&nbsp;
Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice (2018)

The clustered, regularly interspaced, short, palindromic repeat (CRISPR) system has greatly facilitated genome engineering in both cultured cells and living organisms from a wide variety of species. The CRISPR technology has also been explored as novel therapeutics for a number of human diseases. Proof-of-concept data are highly encouraging as exemplified by recent studies that demonstrate the feasibility and efficacy of gene editing-based therapeutic approach for Duchenne muscular dystrophy (DMD) using a murine model. In particular, intravenous and intraperitoneal injection of the recombinant adeno-associated virus (rAAV) serotype rh.74 (rAAVrh.74) has enabled efficient cardiac delivery of the Staphylococcus aureus CRISPR-associated protein 9 (SaCas9) and two guide RNAs (gRNA) to delete a genomic region with a mutant codon in exon 23 of mouse Dmd gene. This same approach can also be used to knock out the gene-of-interest and study their cardiac function in postnatal mice when the gRNA is designed to target the coding region of the gene. In this protocol, we show in detail how to engineer rAAVrh.74-CRISPR vector and how to achieve highly efficient cardiac delivery in neonatal mice.
Abstract 13928: Subclinical Myocardial Dysfunction With Coronavirus Disease 2019 (2020)

Background: Coronavirus disease 2019 (COVID-19) is associated with cardiac injury and overt myocardial dysfunction. However, whether COVID-19 is associated with subclinical myocardial dysfunction is unknown. Methods: We evaluated patients hospitalized for COVID-19 referred for transthoracic echocardiography (TTE), between March 17 and May 22, 2020, with a left ventricular ejection fraction (LVEF) ≥ 50%. Controls in a 1:1 ratio were selected from patients receiving TTE during the same month. Global longitudinal strain (GLS) was used to assess the association of COVID-19 and subclinical myocardial disease. Results: Among 99 patients (49 cases, 50 controls), average GLS was significantly reduced in cases vs. controls (mean ± SD, -14.8 ± 4.0% vs. -21.1 ± 4.0%, p &lt; 0.0001). A total of 82.8% of cases vs. 7.1% of controls had an average GLS below normal (&gt; 18%; p &lt; 0.0001), which persisted despite multivariable adjustment ( Table ). Among COVID-19 patients with a prior TTE, absolute average GLS decreased 3.2% (p = 0.008) despite no change in LVEF (p = 0.41). Average GLS was reduced in non-survivors compared with survivors (p = 0.04), though only septal wall thickness (p = 0.03) was associated with in-hospital mortality on multivariable analysis. Conclusions: Among hospitalized patients receiving TTE, COVID-19 is independently associated with subclinical left ventricular systolic dysfunction in the vast majority of patients, and subclinical LV dysfunction is associated with survival. The clinical implications of these findings should be evaluated in future longitudinal multicenter studies.
Supplementary Table 1 from Carcinomas Contain a Matrix Metalloproteinase–Resistant Isoform of Type I Collagen Exerting Selective Support to Invasion (2023)

Supplementary Table 1 from Carcinomas Contain a Matrix Metalloproteinase–Resistant Isoform of Type I Collagen Exerting Selective Support to Invasion
Sequence of a cDNA specifying subunit VIIc of human cytochromecoxidase (1990)

Journal Article Sequence of a cDNA specifying subunit VIIc of human cytochromec oxidase Get access Yasotoshi Koga, Yasotoshi Koga 1Department of Neurology, Columbia University College of Physicians and Surgeons630 West 168th Street, New York, NY 10032 Search for other works by this author on: Oxford Academic PubMed Google Scholar Gian Maria Fabrizi, Gian Maria Fabrizi 1Department of Neurology, Columbia University College of Physicians and Surgeons630 West 168th Street, New York, NY 10032 Search for other works by this author on: Oxford Academic PubMed Google Scholar Shuji Mita, Shuji Mita 1Department of Neurology, Columbia University College of Physicians and Surgeons630 West 168th Street, New York, NY 10032 Search for other works by this author on: Oxford Academic PubMed Google Scholar Enrica Arnaudo, Enrica Arnaudo 1Department of Neurology, Columbia University College of Physicians and Surgeons630 West 168th Street, New York, NY 10032 Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret I. Lomax, Margaret I. Lomax 2Department of Anatomy and Cell Biology, University of Michigan Medical SchoolAnn Arbor, Ml 48109 Search for other works by this author on: Oxford Academic PubMed Google Scholar Mfon S. Aqua, Mfon S. Aqua 3Department of Molecular Biology and Genetics, and the Center for Molecular Biology, Wayne State University School of MedicineDetroit, MI 48201, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Lawrence I. Grossman, Lawrence I. Grossman 3Department of Molecular Biology and Genetics, and the Center for Molecular Biology, Wayne State University School of MedicineDetroit, MI 48201, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Eric A. Schon Eric A. Schon * 1Department of Neurology, Columbia University College of Physicians and Surgeons630 West 168th Street, New York, NY 100324Department of Genetics and Development, Columbia University College of Physicians and Surgeons630 West 168th Street, New York, NY 10032 *To whom correspondence should be addressed at Department of Neurology, Room BB324, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 3, 11 February 1990, Page 684, https://doi.org/10.1093/nar/18.3.684 Published: 11 February 1990 Article history Received: 04 December 1989 Published: 11 February 1990
Scaling the Data in Multi-tenant Business Support System (2009)

Multi-tenant business support system (BSS) is a form of Software as a Service, which can provide business support services for service carriers at a low cost by leveraging economy of scale. In this paper, we present the architecture of multi-tenant BSS and discuss briefly the approach to achieve configurability, security and scalability of the architecture. Focusing on scalability of data, we propose the entity group-based horizontal partitioning by analyzing entity relationships in the system. Experimental results show that the approach improves the performance.
Multi-perspective Panoramas of Long Scenes (2012)

This paper presents a system for producing multiperspective panoramas for long scenes from dense collections of images. Multi-perspective panoramas are generated by combining different perspectives, including original and novel perspectives. The latter are rendered by our synthesis algorithm, which uses estimated depth information to remove distortions caused by depth parallax. Then, different perspectives are properly combined without noticeable visual artifacts caused by both color inconsistencies and structural misalignments.
Focus Quality Control 30 end mRNA processing: molecular mechanisms and implications for health and disease (2016)

Recent advances in the understanding of the molecular mechanism of mRNA 30 end processing have uncovered a previously unanticipated integrated network of trans-criptional and RNA-processing mechanisms. A variety of human diseases impressively reflect the importance of the precision of the complex 30 end-processing machinery and gene specific deregulation of 30 end processing can result from mutations of RNA sequence elements that bind key specific processing factors. Interestingly, more general deregulation of 30 end processing can be caused either by mutations of these processing factors or by the disturbance of the well-coordinated equilibrium between these factors. From a medical perspective, both loss of function and gain of function can be functionally relevant, and an increasing number of different disease entities exemplifies that in-appropriate 30 end formation of human mRNAs can have a tremendous impact on health and disease. Here, we review the mechanistic hallmarks of mRNA 30 end processing, highlight the medical relevance of deregulation of this important step of mRNA maturation and illustrate the implications for diagnostic and therapeutic strategies.
An X‐Ray, Infrared, and Submillimeter Flare of Sagittarius A* (2008)

Energetic flares are observed in the Galactic supermassive black hole Sagittarius A* from radio to X-ray wavelengths. On a few occasions, simultaneous flares have been detected in IR and X-ray observations, but clear counterparts at longer wavelengths have not been seen. We present a flare observed over several hours on 2006 July 17 with the Chandra X-Ray Observatory, the Keck II telescope, the Caltech Submillimeter Observatory, and the Submillimeter Array. All telescopes observed strong flare events, but the submillimeter peak is found to occur nearly 100 minutes after the X-ray peak. Submillimeter polarization data show linear polarization in the excess flare emission, increasing from 9% to 17% as the flare passes through its peak, consistent with a transition from optically thick to thin synchrotron emission. The temporal and spectral behavior of the flare require that the energetic electrons responsible for the emission cool faster than expected from their radiative output. This is consistent with adiabatic cooling in an expanding emission region, with X-rays produced through self-Compton scattering, although not consistent with the simplest model of such expansion. We also present a submillimeter flare that followed a bright IR flare on 2005 July 31. Compared to 2006, this event had a larger peak IR flux and similar submillimeter flux, but it lacked measurable X-ray emission. It also showed a shorter delay between the IR and submillimeter peaks. Based on these events we propose a synchrotron and self-Compton model to relate the submillimeter lag and the variable IR/X-ray luminosity ratio.
Advanced Modeling in Fuel Cell Systems: A Review of Modeling Approaches (2010)

A review of fuel cell modeling approaches across various length scales is given, with special focus on low-temperature hydrogen-fed polymer electrolyte fuel cell (PEFC) systems.The overall scope of fuel cell modeling is incredibly broad, and ranges from fundamental atomistic modeling of catalytic processes and transport to nearly completely empirically based online system control models.In the first part an overview of the various scales of modeling is given, with some examples from the literature, along with a summary of the common limitations and requirements for successful predictive capabilities.In the second part, a critical analysis of the present state of polymer electrolyte fuel cell performance and water management models is given, and the inability of the existing framework of models to accurately predict the liquid water distribution and transport in the PEFC is demonstrated and discussed.Based on the discussion of the various modeling approaches and the limitations in the current framework, the needs of future research to provide precise fundamental and engineering models are discussed.
T cell synergy in the rat: serologic characterization of T cell subsets. (1980)

The W3/25+ T cell subset in rats, defined by a xenogeneic monoclonal antibody and separated by using the FACS, was demonstrated to be the proliferating cell type in the in vitro MLC and to provide an amplifier function for the W3/25- T cell subset in the generation of cytotoxic effector cells to alloantigenic targets.
Modélisation par éléments finis de l'interaction élastique locale du microscope acoustique à pointe vibrante (2008)

National audience
Microseismic insights into the fracturing behavior of a mature reservoir in the Pembina field, Alberta (2018)

Microseismic source mechanisms (obtained through moment-tensor inversion) provide an understanding of the hydraulic fracturing behavior of a stimulated reservoir, knowledge of which can help to improve production and minimize seismic risk. Seismic source inversion, Gutenberg-Richter [Formula: see text]-value analysis, and geomechanical considerations are carried out to investigate the fracturing behavior for a microseismic data set recorded in the West Pembina field of central Alberta, Canada. A spatial pattern in the fracturing behavior seems apparent in the source mechanism results, showing strong tensile components in between the two observation wells and parallel to the treatment well, and shear-dominated failure mechanisms outside of this zone. This gives the impression that the reservoir experiences two spatially different fracturing behaviors. However, reliability tests using an identical monitoring geometry demonstrate that the change in behavior coincides with a region of unreliable moment-tensor solutions. This region occurs between the two observation wells, casting doubt on the recovered tensile failure mechanisms, thus indicating that only shear-dominated failure is likely to occur. This demonstrates the importance of taking into account the reliability of moment-tensor solutions when interpreting the fracturing behavior of a reservoir. Conversely, analysis of [Formula: see text]-values indicates changes in the behavior between the reservoir (high [Formula: see text]-values) and the sandwiching formations ([Formula: see text]-values closer to one), which is likely due to a lower differential stress within the reservoir, caused by surrounding load-bearing formations. Geomechanical considerations also explain the observed polarity changes in shearing mechanisms as caused by either forward and then reversed slip on preexisting weaknesses or opposing shear motion on either side of the main hydraulic fractures.
Novel Hilbert Spectrum-Based Specific Emitter Identification for Single-Hop and Relaying Scenarios (2015)

A novel approach for specific emitter identification using Hilbert spectrum is proposed for both single-hop and relaying scenarios. In particular, two features, i.e., the energy entropy and color moments, are extracted from the Hilbert spectrum of the signal of interest as identification features. The spectrum is obtained through the Hilbert-Huang transform, which is a powerful tool for the analysis of non-linear and nonstationary signals by decomposing them into a set of intrinsic mode functions. The identification task is solved by applying the support vector machine. We further extend the identification problem to a relaying scenario, in which the fingerprint of different emitters may be contaminated by the relay's fingerprints. To the best of our knowledge, this case has not been investigated so far in the literature. At last, simulation results validate that the proposed approach can effectively cope with the specific emitter identification problems in both single-hop and relaying scenarios.