gebhart/patrepeval huggingface dataset:
GW24-e2367 Tirofiban improves renal outcome in a rat model of ischaemia/reperfusion injury by modulating NO synthases (2013)

Objectives Renal ischaemia/reperfusion (I/R) injury is a common clinical disease. We have known that NO-signal transduction has an important effect on renal I/R injury. NO is produced by NO synthases. Endothelial NO synthase (eNOS) plays a protective role while inducible NO synthase (iNOS) induces impairment. There is evidence that tirofiban may cause alteration of NO production by affecting eNOS/iNOS. So in present study, we investigated whether tirofiban can affect NO Synthases and improve renal outcome in a rat model of I/R injury. Methods Tirofiban (100 µg/kg) was intraperitoneally administered to Sprague-Dawley rats, which were divided into four groups: sham operated control group (N = 3); sham operated plus tirofiban (100 µg/kg) group (N = 3); I/R group (N = 3); I/R plus tirofiban group (N = 3). After 24 h reperfusion, kidney and blood were collected to estimate renal function, oxidative stress, apoptosis of renal tissues and plasma NOx-production. In I/R group, the level of serum urea, Scr, and AST was much higher compared with control. Pathological damage score was also much higher in I/R group. Tirofiban improves renal function damaged by I/R injury and reduce histopathological changes. Besides, tirofiban also decrease oxidative stress, apoptosis and the level of plasm. Results Tirofiban (100 µg/kg) was intraperitoneally administered to Sprague-Dawley rats, which were divided into four groups: sham operated control group (N = 3); sham operated plus tirofiban (100 µg/kg) group (N = 3); I/R group (N = 3); I/R plus tirofiban group (N = 3). After 24 h reperfusion, kidney and blood were collected to estimate renal function, oxidative stress, apoptosis of renal tissues and plasma NOx-production. In I/R group, the level of serum urea, Scr, and AST was much higher compared with control. Pathological damage score was also much higher in I/R group. Tirofiban improves renal function damaged by I/R injury and reduce histopathological changes. Besides, tirofiban also decrease oxidative stress, apoptosis and the level of plasma NOx. Conclusions Tirofiban plays a protective role in renal I/R injury. And the alterations of NO-transduction related to eNOS/iNOS may participate in the mechanism of tirofiban protection.
Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction and the 20-Year Cumulative Incidence of Early Age-Related Macular Degeneration (2014)

IMPORTANCE Modifying levels of factors associated with age-related macular degeneration (AMD) may decrease the risk for visual impairment in older persons. OBJECTIVE To examine the relationships of markers of inflammation, oxidative stress, and endothelial dysfunction to the 20-year cumulative incidence of early AMD. DESIGN, SETTING, AND PARTICIPANTS This longitudinal population-based cohort study involved a random sample of 975 persons in the Beaver Dam Eye Study without signs of AMD who participated in the baseline examination in 1988-1990 and up to 4 follow-up examinations in 1993-1995, 1998-2000, 2003-2005, and 2008-2010. EXPOSURES Serum markers of inflammation (high-sensitivity C-reactive protein, tumor necrosis factor-α receptor 2, interleukin-6, and white blood cell count), oxidative stress (8-isoprostane and total carbonyl content), and endothelial dysfunction (soluble vascular cell adhesion molecule-1 and soluble intercellular adhesion molecule-1) were measured. Interactions with complement factor H (rs1061170), age-related maculopathy susceptibility 2 (rs10490924), complement component 3 (rs2230199), and complement component 2/complement factor B (rs4151667) were examined using multiplicative models. Age-related macular degeneration was assessed from fundus photographs. MAIN OUTCOMES AND MEASURES Early AMD defined by the presence of any size drusen and the presence of pigmentary abnormalities or by the presence of large-sized drusen (≥125-μm diameter) in the absence of late AMD. RESULTS The 20-year cumulative incidence of early AMD was 23.0%. Adjusting for age, sex, and other risk factors, high-sensitivity C-reactive protein (odds ratio comparing fourth with first quartile, 2.18; P = .005), tumor necrosis factor-α receptor 2 (odds ratio, 1.78; P = .04), and interleukin-6 (odds ratio, 1.78; P = .03) were associated with the incidence of early AMD. Increased incidence of early AMD was associated with soluble vascular cell adhesion molecule-1 (odds ratio per SD on the logarithmic scale, 1.21; P = .04). CONCLUSIONS AND RELEVANCE We found modest evidence of relationships of serum high-sensitivity C-reactive protein, tumor necrosis factor-α receptor 2, interleukin-6, and soluble vascular cell adhesion molecule-1 to the 20-year cumulative incidence of early AMD independent of age, smoking status, and other factors. It is not known whether these associations represent a cause and effect relationship or whether other unknown confounders accounted for the findings. Even if inflammatory processes are a cause of early AMD, it is not known whether interventions that reduce systemic inflammatory processes will reduce the incidence of early AMD.
Flavonoide aus Rhodiola rosea mit moderaten MAO-inhibierenden Eigenschaften (2017)

Extrakte aus der Wurzel von Rhodiola rosea werden als phytotherapeutisches Adaptogen zur Verminderung von Stressauswirkungen, Anregung des Nervensystems, Erhöhung des Leistungsvermögens und Linderung von Erschöpfungszuständen eingesetzt [1]. Zusätzlich wird der Extrakt verstärkt auf seine klinische antidepressive Wirksamkeit hin untersucht [2]. Als möglicher Wirkmechanismus für diese Aktivität wird eine Hemmung von Monoaminoxidase (MAO) A und B diskutiert. Als wirksame Bestandteile wurden nicht Hauptinhaltsstoffe wie Rosavine und Salidorosid nachgewiesen, sondern Rosiridin sowie Mischungen von Rhodiolosid B und C als aktive Inhaltsstoffe identifiziert [3]. Ziel der vorliegenden Arbeit war es, diese Beobachtung zu verifizieren und die MAO-inhibierenden Wirkungen von Rhodiola-Inhaltsstoffen näher zu charakterisieren.
AKAP220 Protein Organizes Signaling Elements That Impact Cell Migration (2011)

Cell movement requires the coordinated reception, integration, and processing of intracellular signals. We have discovered that the protein kinase A anchoring protein AKAP220 interacts with the cytoskeletal scaffolding protein IQGAP1 to influence cell motility. AKAP220/IQGAP1 networks receive and integrate calcium and cAMP second messenger signals and position signaling enzymes near their intended substrates at leading edges of migrating cells. IQGAP1 supports calcium/calmodulin-dependent association of factors that modulate microtubule dynamics. AKAP220 suppresses GSK-3β and positions this kinase to allow recruitment of the plus-end microtubule tracking protein CLASP2. Gene silencing of AKAP220 alters the rate of microtubule polymerization and the lateral tracking of growing microtubules and retards cell migration in metastatic human cancer cells. This reveals an unappreciated role for this anchored kinase/microtubule effector protein network in the propagation of cell motility.
Algebraic differentiators through orthogonal polynomials series expansions (2017)

Numerical differentiation is undoubtedly a fundamental problem in signal processing and control engineering, due to its countless applications. The goal of this paper is to address this question within an algebraic framework. More precisely, we consider a noisy signal and its orthogonal polynomial series expansion. Through the algebraic identification of the series coefficients, we then propose algebraic differentiators for the signal. Examples based on Hermite and Laguerre polynomials illustrate these algebraic differentiators.
Synthesis of Methylenebis(Phosphonate) Analogues of 2-, 4-, and 6-Pyridones of Nicotinamide Adenine Dinucleotide (2011)

The synthesis of metabolically stable methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide (NAD) is reported. In contrast to natural pyrophosphates, these NAD analogues are able to penetrate the cell membrane and can be used as probes in cellular assays.
Addition of triphenylphosphonium salts to aldehydes. Remarkable counterion effects on phosphorus proton couplings (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of triphenylphosphonium salts to aldehydes. Remarkable counterion effects on phosphorus proton couplingsRichard A. Dal Canto and Eric J. RoskampCite this: J. Org. Chem. 1992, 57, 1, 406–407Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jo00027a077https://doi.org/10.1021/jo00027a077research-articleACS PublicationsRequest reuse permissionsArticle Views190Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 1652: Targetome profiling and genetic association analyses implicate miR-202 in follicular lymphomagenesis (2012)

Abstract Complex etiologic heterogeneity among non-Hodgkin's lymphoma (NHL) subtypes has made it difficult to identify risk factors for this disease. However, recent genetic association analyses, including two genome-wide association studies, suggest that genetic susceptibility to NHL may be strongest for the follicular lymphoma subtype. As recent studies have demonstrated that microRNAs (miRNAs) may be important in the etiology of many cancer types, including NHL, we performed a population-based genetic association study which identified a polymorphism in the precursor of miR-202 that is strongly associated with follicular lymphoma risk (rs12355840 in miR-202: PTREND = 0.006). An in vitro functional genetics assay demonstrated that the polymorphism is biologically active, and operates by altering the processing efficiency of the miR-202 precursor to the mature effector miRNA species. A ribonucleoprotein immunoprecipitation-microarray (RIP-Chip) assay, performed with an anti-AGO2 antibody followed by a whole-genome array, was used to characterize the miR-202 targetome, and selected targets were confirmed using a 3′UTR luciferase assay. Among the identified targets were several transcripts with relevance for tumorigenesis, including the miRNA biogenesis gene DICER1 and the lymphoma-associated cell cycle regulator and proto-oncogene SKP2. Both of these genes have been shown to be upregulated in lymphomas, which is consistent with our data, which show that the miR-202 risk allele is associated with diminished mature miR-202 levels in vitro. Taken together, these findings suggest that rs12355840 may represent a novel risk biomarker for follicular lymphoma, and implicate miR-202 in follicular lymphomagenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1652. doi:1538-7445.AM2012-1652
Fisheries in transition: Food and nutrition security implications for the global South (2013)

Fisheries and fish supply are undergoing a fundamental structural transition, as indicated by a ten country analysis. Aquaculture now provides around half the fish for direct human consumption and is set to grow further, but capture fisheries continue to make essential contributions to food and nutrition security throughout the global South. Capture fisheries provide diverse, nutritionally valuable fish and fish products which are often culturally preferred and easily accessed by the poor. Technological changes in aquaculture have dramatically increased fish supply, lowered relative fish prices, and reigned in price volatility. Policies that recognize and safeguard the diversity and complementarity of roles played by capture fisheries and aquaculture are needed to ensure that the transition in fisheries sustainably improves food and nutrition security in the global South.
Severe Staphylococcal Sepsis in Adolescents in the Era of Community-Acquired Methicillin-Resistant Staphylococcus aureus (2005)

Severe staphylococcal infections in previously healthy adolescents without predisposing risk factors have presented more frequently at Texas Children's Hospital since September 2002. CA MRSA and clonally related CA MSSA characterized as USA300 and sequence type 8 have been isolated from these patients.
HIGH VOLTAGE SWITCHING P-CHANNEL STRUCTURE FOR CMOS ARCHITECTURES (1988)

An analysis of a P-ch High Voltage structure fully compatible with all CMOS architectures is presented. It points out the critical role played by drain extension layer on electrical device performance, and by the field thick oxide periphery on the device reliability. These results are useful in designing HV process compatible devices in advanced CMOS technology.
Pharmacological treatment of Alzheimer's dementia: State of the art and current dilemmas (2008)

Alzheimer's disease (AD) is one of the most frequent disorders of the central nervous system characterised by a progressive cognitive decline. The demographic changes of our aging population lead to increased numbers of patients and a need of early diagnosis and treatment of cognitive and behavioural symptoms of AD. Drugs are available for symptomatic treatment of AD. The pharmacological treatment of behavioural disturbances experienced dynamic changes in the last years. In this paper, we present the current state and future perspectives in the treatment of AD. Furthermore, we discuss current difficulties regarding AD treatment by looking for explanations for a still unsatisfying rate of state-of-the-art treatment of AD-patients.
An all‐solid‐state pulsed power generator using a high‐speed gate‐turn‐off thyristor and a saturable transformer (2002)

Abstract Recently, high‐repetition‐rate pulsed power generators using a magnetic pulse compression circuit (MPC) and semiconductor switches have been developed. We have developed a new all‐solid‐state pulsed power generator for use with a high‐repetition‐rate excimer laser and in an ozonizer. The all‐solid‐state generator consists of a semiconductor switch and an MPC with saturable inductors (SI) and a saturable transformer (ST). The semiconductor switch is a high‐speed gate‐turn‐off (GTO) thyristor. The switching speed of the GTO thyristor was improved, decreasing the switching loss. The ST with an Fe‐based nanocrystalline magnetic core has two functions, those of step‐up transformer and magnetic switch. The high‐speed GTO thyristor and the new MPC can be used to realize a high‐performance, simple all‐solid‐state pulsed power generator. © 2002 Wiley Periodicals, Inc. Electr Eng Jpn, 140(4): 17–26, 2002; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.2006
Low-loss (~0.15 dB) arc fusion splicing of erbium-doped fibers with high strength (~400 ksi) for highly reliable optical amplifier systems (1992)

Erbium-doped fiber amplifiers have found widespread use in 1.55- μm systems. The design of the fiber structure for optimized performance has led to fibers with small mode field diameters,1 leading to a large mismatch in mode field between the Er-doped fiber (3-4 μm) and the transmission fiber (8-9 μm). Calculated splice losses between these fiber pairs are 1.9-3.4 dB, while fusion splices using standard splicing parameters for transmission fiber lead to splice losses of 0.5-1.0 dB. By optimizing the splicing parameters to allow modification of the core profile during fusion2 the mode fields have been nearly matched and the splice loss has been reduced to ~0.15 dB per splice. To achieve the necessary mode field expansion, heating times of up to 14 s were used. The curve of splice loss vs heating time (Fig. 1) shows optimization of the fusion time for the optimum arc intensity. The mode field diameters, for a variety of splice conditions, were calculated using the Petermann II definition from measurements of the far-field power profiles. Those calculations indicate that the mode field diameter of the fiber can be expanded by more than a factor of 2 during splicing.
2016 자율경영고시 사회적 기업의 사회적, 경제적 성과 연구 (2017)

본 연구는 한국사회적기업진흥원에서 공시한 2016년 사회적 기업 자율경영공시 자료를 활용하여 정 부의 사회적 기업 육성을 위한 9년간의 정책적 지원에 따른 사회적 기업의 사회적, 경제적 성과를 분석하는데 목적이 있다. 사회적 기업의 사회적 성과 지표로 취약계층고용을 선정하였고 경제적 성과 지표로 당기순이익을 선정하여 분석하였다. 독립변수로는 자기자본,...
Microbiota Promotes Chronic Pulmonary Inflammation by Enhancing IL-17A and Autoantibodies (2015)

Collectively, our data indicate that host-microbial cross-talk promotes inflammation and could underlie the chronicity of inflammatory lung diseases.
On the decoder error probability for Reed - Solomon codes (Corresp.) (1986)

Upper bounds On the decoder error probability for Reed-Solomon codes are derived. By definition, "decoder error" occurs when the decoder finds a codeword other than the transitted codeword; this is in contrast to "decoder failure," which occurs when the decoder fails to find any codeword at all. These results imply, for example, that for a <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</tex> error-correcting Reed-Solomon code of length <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q - 1</tex> over GF <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(q)</tex> , if more than <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</tex> errors occur, the probability of decoder error is less than <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/t!</tex> .
SaTellite: a visualization and navigation tool for hypermedia (1990)

SaTellite is a visualization and navigation tool for a hypermedia system. It is based on the concept of affinity between objects; that is, a relationship with an associated intensity. The user is presented with a two dimensional map that provides a view of the hypermedia environment where objects lying close together have a greater affinity than those lying further apart. The system provides different views by allowing modification of the underlying measure of affinity. The system is also able to track dynamically the evolution of the objects' relationships.
The Evolving Role of Staging Laparoscopy in the Treatment of Colorectal Hepatic Metastasis (2005)

In the regional management of isolated colorectal hepatic metastasis, SL/IOUS avoids unnecessary laparotomies and influences definitive surgical intervention in a substantial proportion of patients.
Two-Stream Dictionary Learning Architecture for Action Recognition (2017)

In this paper, a novel method based on the two-stream dictionary learning architecture for human action recognition is proposed. The architecture consists of interest patch (IP) detector and descriptor, two-stream dictionary models, and support vector machine (SVM) for classification. The novel IP detector combines a human detector and a contour detector to extract patches of interest on human contours. Then the IP descriptors are calculated in spatial stream and temporal stream separately. In each stream, a dictionary is trained for each action with the IP descriptors as an action model. In this way, measuring the similarity between an action sequence and an action model is transformed to reconstructing the IPs in this sequence with the model and computing the reconstruction error. For each action, an IP distribution histogram is constructed and the histogram is further used to train an SVM classifier in each stream. A score fusion method is applied to fuse the spatial and temporal SVM classification results to make a final decision. The proposed architecture is examined on four public data sets with different background complexities and camera motion conditions: Weizmann data set, KTH data set, Olympic sports data set, and HMDB51 data set. The results are further compared with state-of-the-art approaches in the experiment section to confirm the effectiveness of this architecture.
Transition Effects in Compatible Color Television (1954)

Perfect reproduction of a scene by color television requires that three independent colorimetric quantities be known for each point of the picture. The particular three quantities chosen to be transmitted and the bandwidth assigned to each are among the system variables which must be specified. The optimum choice of these parameters is decided principally by subjective rating of the reproduced color picture with particular regard to color and luminance transitions at boundaries in the picture content. This paper describes an experimental video frequency color television system in which these variables can be isolated and conveniently studied. With this system the make-up of color difference signal packages and their assigned bandwidths are switchable so that an observer can view in sequence and on the same display a picture transmitted utilizing various signal forms. Investigations using this system suggested that certain undesired luminance variations were the most objectionable feature in the reproduction of the color transitions, and led to the development of a means for predistorting the luminance signal to compensate for these variations in the reproduction. This device will be described in the paper.
Acousto-optical spectral technologies (2015)

State-of-the-art acousto-optical (AO) spectral technologies are analyzed. The main types of existing devices and systems based on AO filters are described along with those now at the developmental stage. Original methods of measurement and analysis specific to spectral AO elements are discussed.
Industasis, a Promotion of Tumor Formation by Nontumorigenic Stray Cells (2009)

A tumor cell is formed when a critical amount of endogenous and/or exogenous tumorigenic stimuli is exceeded. We have shown that the transient presence of nontumorigenic stray cells in tissues of experimental animals that contain cells with a subcritical set of genetic mutations can act as a tumor-promoting stimulus. To induce somatic mutations in all chicken tissues, we have used the MAV-2 retroviral insertion system that almost exclusively generates nephroblastomas. MAV-2 mutagenized animals i.v. inoculated with nonmalignant cells developed early clonal lung tumors before nephroblastomas. Importantly, the injected cells did not become a component of resultant tumors. Lung tumors displayed specific mutational signature characterized by an insertion of MAV-2 provirus into the fyn-related kinase (frk) promoter that results in the overexpression of the frk gene. In contrast, plag1, foxP, and twist genes were most often mutagenized in nephroblastomas. Based on such observations, we propose the mechanism termed industasis, a promotion of fully malignant phenotype of incipient tumor cell by stray cells, and hypothesize that it might be the underlying cause of human multiple primary tumors.