gebhart/patrepeval huggingface dataset:
TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity (2018)

Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4<sup>+</sup> T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4<sup>+</sup> T cells to IL-10-producing, TIGIT<sup>+</sup> FoxP3<sup>+</sup>-induced regulatory T cells that non-specifically suppress bystander T cells and inhibit dendritic cell maturation. Differentiation of Mreg-induced Tregs relies on multiple non-redundant mechanisms that are not exclusive to interaction of Mregs and T cells, including signals mediated by indoleamine 2,3-dioxygenase, TGF-β, retinoic acid, Notch and progestagen-associated endometrial protein. Preoperative administration of donor-derived Mregs to living-donor kidney transplant recipients results in an acute increase in circulating TIGIT<sup>+</sup> Tregs. These results suggest a feed-forward mechanism by which Mreg treatment promotes allograft acceptance through rapid induction of direct-pathway Tregs.
A 3-Bridge LLC Resonant Converter Operating with A Wide Output Voltage Control Range Using Morphing Control for Mode Transitions (2019)

This paper presents a 3-bridge LLC resonant converter operating with a wide output voltage control range by using the morphing control for topology transitions caused by the change of converter's operating modes. Morphing control between hysteresis bands of narrow is achieved via frequency modulation (FM) of the primary switching devices and by changing the duty of the switching devices involved in topology mode transition. As the converter transits from one operating mode to the other, the primary and secondary terminals of the two transformers are respectively connected in parallel or in series and enable to achieve a wide controllable output voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> ~8V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> ). The feasibility of the proposed converter is verified with experimental results of a 5kW prototype.
ChemoPlus Gown may Not Afford Adequate Protection; Archaic Liquid Measurement is a Factor in Medication Errors; Drainage System Has Luer Connector; Reuse of Insulin Pens; ISMP Consumer Web Site Updated (2012)

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Improvement of LysM-Mediated Surface Display of Designed Ankyrin Repeat Proteins (DARPins) in Recombinant and Nonrecombinant Strains of Lactococcus lactis and Lactobacillus Species (2015)

Safety and probiotic properties make lactic acid bacteria (LAB) attractive hosts for surface display of heterologous proteins. Protein display on nonrecombinant microorganisms is preferred for therapeutic and food applications due to regulatory requirements. We displayed two designed ankyrin repeat proteins (DARPins), each possessing affinity for the Fc region of human IgG, on the surface of Lactococcus lactis by fusing them to the Usp45 secretion signal and to the peptidoglycan-binding C terminus of AcmA, containing lysine motif (LysM) repeats. Growth medium containing a secreted fusion protein was used to test its heterologous binding to 10 strains of species of the genus Lactobacillus, using flow cytometry, whole-cell enzyme-linked immunosorbent assay (ELISA), and fluorescence microscopy. The fusion proteins bound to the surfaces of all lactobacilli; however, binding to the majority of bacteria was only 2- to 5-fold stronger than that of the control. Lactobacillus salivarius ATCC 11741 demonstrated exceptionally strong binding (32- to 55-fold higher than that of the control) and may therefore be an attractive host for nonrecombinant surface display. Genomic comparison of the species indicated the exopolysaccharides of Lb. salivarius as a possible reason for the difference. Additionally, a 15-fold concentration-dependent increase in nonrecombinant surface display on L. lactis was demonstrated by growing bacteria with sublethal concentrations of the antibiotics chloramphenicol and erythromycin. Nonrecombinant surface display on LAB, based on LysM repeats, was optimized by selecting Lactobacillus salivarius ATCC 11741 as the optimal host and by introducing antibiotics as additives for increasing surface display on L. lactis. Additionally, effective display of DARPins on the surfaces of nonrecombinant LAB has opened up several new therapeutic possibilities.
Hemodynamic System Analysis of Intraarterial Microaxial Pumps In Vitro and In Vivo (1996)

Because of the lack of a sophisticated pump management system, the performance of the Hemopump in patients cannot assessed successfully. To clarify the interrelationship between an intravascular nonpulsatile pump and a pulsating ventricle, an in vitro study was set up under controlled conditions. Before these in vitro experiments, a series of in vivo experiments were performed in sheep using Hp31 cannulae. As anticipated, the resulting pulsatile pump flow was a function of the momentary pressure difference across the pump. This varying pump flow showed a significant flow loop hysteresis, indicating that the pressure difference across the pump is not the only parameter governing momentary pump flow of a rotary pump operating at constant speed in a pulsatile environment. Furthermore, flow in the Hp31 was significantly influenced by the inflow situation, blood supply, size of the ventricular cavity, and shape and position of the inflow cannula within the ventricle. Pulsatile flow conditions with good as well as impaired inflow into the pump were accordingly simulated in vitro to verify the in vivo measurements, to characterize the various inflow conditions, and to discuss methods of improved pump management. As a result of the in vivo and in vitro experiments, one can rely on the measurement of nonpulsatile in vitro flow and pressure differences across the pump to characterize the momentary pump flow for good inflow conditions into the pump. For these situations, the flow hysteresis produced, caused by fluid inertia within the pump and cannula, can be neglected. In contrast, for an impaired inflow situation, the calculated pump flow based on pressure difference measurements can be misleading. Consequently, an improved pump management system is required to adjust the pump speed, the pump performance, to any kind of impaired inflow.
Study of run-length coding algorithm (2001)

RLC is very simple, and its speed of coding and decoding is quick. So it has a wide application. This paper gives a brief introduction to the principles and realization technology of RLC. Researching the RLC technology is in a relatively comprehensive way, including the RLC compression models, the processes of data compression and uncompression, and giving the flow diagrams and relevant programs.
Synthesis and Characterization of Nanostructured Cobalt Hexacyanoferrate (2010)

Cobalt hexacyanoferrate (CoHCF) nanoparticles have been synthesized by mixing aqueous solutions of K3Fe(CN)6 and CoCl2 under vigorous stirring at different temperatures and following two different procedures, drop-by-drop or immediate mixing. The resulting CoHCF nanoparticles, with dimensions of several tens of nanometers, were characterized using TEM, SEM-EDX, IR, and XRD. Their electrochemical behavior was investigated in comparison with the CoHCF powder bulk compound. The CoHCF nanoparticles exhibit an electrochemically driven conversion to the bulk one that has been investigated by a chemometric approach in order to establish the best synthetic parameters. The rate and the degree of conversion depend on the synthesis temperature.
Fracture-separation of the distal humeral epiphysis in young children. (1979)

Fracture-separation of the distal humeral epiphysis in young children is frequently misdiagnosed as a fracture of the lateral humeral condyle or a dislocation of the elbow. The roentgenographic relationships between the ossification center of the capitulum humeri and the radius are important in distinguishing between the three conditions. Arthrographic studies in our patients showed that this is an extracapsular supracondylar fracture. In six fracture-separations treated either by open reduction and wire fixation or in overhead traction, the results were excellent.
Spatial correlation in ultrawideband channels (2008)

Correlated fading adversely affects the spatial multiplexing and diversity performance of multiple-antenna systems. This paper presents an empirical investigation of spatial correlation in ultrawideband (UWB) indoor channels in the FCC- allocated 3.1-10.6 GHz band. The impact of a number of system parameters on spatial correlation at the receiver is evaluated. It is found that the coherence distance falls with channel bandwidth in endfire arrays but not in broadside arrays. The complex correlation decays less rapidly with distance in broadside arrays than in endfire arrays, especially under line-of-sight, but the envelope correlation is circularly symmetric in space. Strong dependence of spatial correlation and coherence distance on the channel center frequency is observed. Furthermore, horizontally polarized links are found to exhibit less correlation than vertically polarized links. A discussion of the implications of these results for multiple-antenna UWB systems is provided.
Optically pumped CW (Continuous Wave) semiconductor ring laser (1986)

Abstract : This patent discloses an optically pumped semiconductor ring laser having a plurality of reflective elements optically aligned with one another to form a ring-shaped resonant cavity. A semiconductor lasing medium is mounted within the ring-shaped resonant cavity by a transparent, heat conductive mount located within a vacuum/cooling chamber of the type which allows the passage of a laser beam therethrough. A pump beam initiates a lasing action within the ring-shaped resonant cavity to produce said laser beam and said laser beam exits the resonant cavity as a pair of outputs. An alternate embodiment of the above described semiconductor ring laser provides a semblance of unidirectional lasing operation.
Stabilization of Iron (Micro)Particles with Polyhydroxybutyrate for In Situ Remediation Applications (2016)

Groundwater is an extremely important resource that may, however, contain a variety of toxic and bioaccumulative contaminants. Traditional “Pump and Treat” technologies for treating contaminated groundwater are no longer time- or cost-effective; therefore, new technologies are needed. In this work, we synthesized core–shell materials of micrometric dimensions based on the interaction of iron particles (the core) and fermentable biopolymers such as polyhydroxybutyrate (PHB, the surrounding shell) to be used in permeable reactive barriers for the removal of chlorinated pollutants from contaminated groundwater. The materials were prepared by precipitation techniques that allowed stable preparations to be obtained, whose chemico-physical properties were thoroughly characterized by scanning electron microscopy, porosimetry, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analyses, disc centrifuge analysis, and dynamic light scattering. The properties of the prepared materials are very promising, and may enhance the performance of permeable reactive barriers towards chlorinated compounds.
Review: The strobilurin fungicides (2004)

Abstract The original article to which this Correction refers was published in Pest Management Science 58 (7): 649–662 (2002).Copyright © 2004 Society of Chemical Industry
A Vision of 6G Wireless Systems: Applications, Trends, Technologies, and Open Research Problems (2019)

The ongoing deployment of 5G cellular systems is continuously exposing the inherent limitations of this system, compared to its original premise as an enabler for Internet of Everything applications. These 5G drawbacks are spurring worldwide activities focused on defining the next-generation 6G wireless system that can truly integrate far-reaching applications ranging from autonomous systems to extended reality. Despite recent 6G initiatives (one example is the 6Genesis project in Finland), the fundamental architectural and performance components of 6G remain largely undefined. In this article, we present a holistic, forward-looking vision that defines the tenets of a 6G system. We opine that 6G will not be a mere exploration of more spectrum at high-frequency bands, but it will rather be a convergence of upcoming technological trends driven by exciting, underlying services. In this regard, we first identify the primary drivers of 6G systems, in terms of applications and accompanying technological trends. Then, we propose a new set of service classes and expose their target 6G performance requirements. We then identify the enabling technologies for the introduced 6G services and outline a comprehensive research agenda that leverages those technologies. We conclude by providing concrete recommendations for the roadmap toward 6G. Ultimately, the intent of this article is to serve as a basis for stimulating more out-of-the-box research around 6G.
The economics of amorphous core power transformers for induction heating applications at 20–50 kHz (1991)

The advantages of the use of amorphous magnetic cores in power transformers for induction heating applications in the frequency range 20–50 kHz are discussed. These advantages are pointed out presenting the characteristics and costs at different frequencies of a shell-type pancake coils power unit.
The Complement Inhibitor Factor H Generates an Anti-Inflammatory and Tolerogenic State in Monocyte-Derived Dendritic Cells (2016)

The activation of the complement system is a key initiating step in the protective innate immune-inflammatory response against injury, although it may also cause harm if left unchecked. The structurally related soluble complement inhibitors C4b-binding protein (C4BP) and factor H (FH) exert a tight regulation of the classical/lectin and alternative pathways of complement activation, respectively, attenuating the activity of the C3/C5 convertases and, consequently, avoiding serious damage to host tissues. We recently reported that the acute-phase C4BP isoform C4BP lacking the β-chain plays a pivotal role in the modulation of the adaptive immune responses. In this study, we demonstrate that FH acts in the early stages of monocyte to dendritic cell (DC) differentiation and is able to promote a distinctive tolerogenic and anti-inflammatory profile on monocyte-derived DCs (MoDCs) challenged by a proinflammatory stimulus. Accordingly, FH-treated and LPS-matured MoDCs are characterized by altered cytoarchitecture, resembling immature MoDCs, lower expression of the maturation marker CD83 and the costimulatory molecules CD40, CD80, and CD86, decreased production of key proinflammatory Th1-cytokines (IL-12, TNF-α, IFN-γ, IL-6, and IL-8), and preferential production of immunomodulatory mediators (IL-10 and TGF-β). Moreover, FH-treated MoDCs show low Ag uptake and, when challenged with LPS, display reduced CCR7 expression and chemotactic migration, impaired CD4(+) T cell alloproliferation, inhibition of IFN-γ secretion by the allostimulated T cells, and, conversely, induction of CD4(+)CD127(low/negative)CD25(high)Foxp3(+) regulatory T cells. Thus, this novel noncanonical role of FH as an immunological brake able to directly affect the function of MoDCs in an inflammatory environment may exhibit therapeutic potential in hypersensitivity, transplantation, and autoimmunity.
Chemical Signals from Host Plant and Sexual Behavior in a Moth (1992)

In the phytophagous corn earworm, Helicoverpa (Heliothis) zea, females delay their reproductive behaviors until they find a suitable host on which to deposit their eggs. Perception of volatile chemical signals from corn silk triggers the production of sex pheromone followed by its release, which leads to mating. Several natural corn silk volatiles, including the plant hormone ethylene, induced pheromone production in H. zea females. Because H. zea larvae feed on the fruiting parts of a wide variety of hosts, ethylene, which is associated with fruit ripening, could act as a common cue.
A new threshold-voltage compensation technique of IGZO and LTPS for AMOLED display pixel circuit (2017)

This work presents a voltage programmable pixel circuit with a new threshold-voltage compensation technique for AMOLED displays using Indium Gallium Zinc oxide thin-film transistors (IGZO-TFT) or Low-Temperature Polycrystalline Silicon (LTPS-TFT). One of the advantages of the proposed pixel design is the simplicity of the circuit due to the fact that it requires only four TFTs and one capacitor. The main advantage of the proposed pixel design is that the current of the OLED is almost independent of the threshold voltage of the driving TFT and well controlled. Also, the threshold voltage compensation technique is implementing with a static circuit, resulting to fast response time, similar to the conventional 2T1C response time which is the fastest circuit.
Primed in situ DNA amplification (PIDA) (1994)

A novel PCR in situ protocol is described which can be implemented in one day. An initial amplification step with a single primer pair is followed by an amplification with an internal oligonucleotide probe with labeled nucleotides (dig-dUTP). Detection is then accomplished with an antidigoxigenin antibody and substrate solution. This rapid and sensitive method may be useful in diagnosing low copy DNA in tissue specimens and cells.
The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis (2001)

This is, to our knowledge, the first demonstration that in primary knee OA varus alignment increases risk of medial OA progression, that valgus alignment increases risk of lateral OA progression, that burden of malalignment predicts decline in physical function, and that these effects can be detected after as little as 18 months of observation.
Optical Spectroscopy of Biological Materials (2009)

Abstract In this chapter, optics of biological tissues and blood is briefly discussed. Methods and algorithms for solving the inverse problem of finding tissue and blood optical parameters, such as absorption and scattering coefficients, anisotropy factor, and refractive index are presented. Measuring techniques, such as integrating sphere, spatially resolved, time‐, and angular‐resolved, and optical coherence tomography (OCT), as well as inverse methods, such as adding‐doubling and inverse Monte Carlo, are reviewed. Data on optical properties of human tissue and blood measured in vitro, ex vivo, and in vivo are presented.
Dynamic aberration control testbed for the characterization of multiple wavefront sensors (2005)

An optical testbed has been developed for the comparative analysis of wavefront sensors based on a modified Mach Zender interferometer design. This system provides simultaneous measurements of the wavefront sensors on the same camera by using a common aberrator. The initial application for this testbed was to evaluate a Shack-Hartmann and Phase Diversity wavefront sensors referenced to a Mach-Zender interferometer. This testbed has the added benefit of being able to train the deformable mirror against the spatial light modulator and evaluate its ability to compensate the spatial light modulator. In the paper we present some results from the wavefront sensors along with preliminary results from the wavefront corrective elements in the optical testbed.
A case study of an automatic volume control interface for a telepresence system (2015)

The study of the telepresence robot as a tool for telecommunication from a remote location is attracting a considerable amount of attention. However, the problem arises that a telepresence robot system does not allow the volume of the user's utterance to be adjusted precisely, because it does not consider varying conditions in the sound environment, such as noise. In addition, when talking with several people in remote location, the user would like to be able to change the speaker volume freely according to the situation. In a previous study, a telepresence robot was proposed that has a function that automatically regulates the volume of the user's utterance. However, the manner in which the user exploits this function in a practical situation needs to be investigated. We propose a telepresence conversation robot system called “TeleCoBot.” TeleCoBot includes an operator's user interface, through which the volume of the user's utterance can be automatically regulated according to the distance between the robot and the conversation partner and the noise level in the robot's environment. We conducted a case study, in which the participants played a game using TeleCoBot's interface. The results of the study reveal the manner in which the participants used TeleCoBot and the additional factors that the system requires.
Predicting water content using linear spectral mixture model on soil spectra (2013)

Remote sensing has been widely applied for soil moisture estimation. However, such estimates become difficult to obtain and can be inaccurate when applied to complex earth surfaces with more than one soil type because of the interference of spectral signals from different soil components. This study aims to develop a moisture prediction method that is insensitive to soil types; this is based on in situ samples collected from an intertidal zone in Jiangsu Province in China and on laboratory measurements of soil spectra. The results demonstrate that for a reflectance-based method, moisture content is closely related to reflectance on the three wavebands centered at 2143, 1760, and 742 nm for four types of soil (sand, silty sand, sandy silt, and silt) considered separately; the relationship is not close if all soil types are mixed together (R 2 =0.77 ). To develop the desired model, a linear spectral mixture model (LSMM) was employed to extract parameter water abundance (Wa: information on soil water content) in advance, while eliminating redundant information from other soil components. Wa has a relatively higher correlation (R 2 =0.82 ) than reflectance with moisture content for a mixed soil type. Thus, employing the LSMM helps realize a practical water content estimation model for predicting moisture over complex earth surfaces, because it has the potential of eliminating spectral effects from soil components.
Análise do algoritmo single-bit de geração de chaves criptográficas usando informação do canal (2019)

Resumo-