gebhart/patrepeval huggingface dataset:
SAP HANA – From Relational OLAP Database to Big Data Infrastructure (2015)

SAP HANA started as one of the best-performing database engines for OLAP workloads strictly pursuing a main-memory centric ar- chitecture and exploiting hardware developments like large number of cores and main memories in the TByte range. Within this pa- per, we outline the steps from a traditional relational database en- gine to a Big Data infrastructure comprising different methods to handle data of different volume, coming in with different velocity, and showing a fairly large degree of variety. In order to make the presentation of this transformation process more tangible, we dis- cuss two major technical topics-HANA native integration points as well as extension points for collaboration with Hadoop-based data management infrastructures. The overall of goal of this paper is to (a) review current application patterns and resulting technical challenges as well as to (b) paint the big picture for upcoming ar- chitectural designs with SAP HANA database as the core of a SAP Big Data infrastructure.
Pd-Catalyzed C4-Dearomative Allylation of Benzyl Ammoniums with Allylstannanes (2020)

A dearomative C4-allylation of benzyl ammoniums with allylstannanes by a palladium catalysis is described. A triarylphosphine-ligated palladium catalyst, which is capable of cleaving benzylic C–N bonds, realized facile dearomative reactions with C4 selectivity. Combined with precedented C2- and C3-selective functionalizations of benzyl amine derivatives, the present reaction can provide a new synthetic option for the synthesis of multi-substituted alicyclic compounds as well as aromatic compounds.
Effects of water nanodroplets on skin moisture and viscoelasticity during air‐conditioning (2013)

Skin deformation of the face was improved by mist, suggesting hydration of the SC by mist. The change in TEWL was influenced by mist, suggesting supply of water to the skin, particularly the SC, by mist. These data indicated that a mist of water nanodroplets played an important role in softening skin in an air-conditioned room without increasing excess humidity.
Chiral Phases of a Confined Cholesteric Liquid Crystal: Anchoring-Dependent Helical and Smectic Self-Assembly in Nanochannels (2016)

Chiral liquid crystals (ChLCs) allow a fundamental insight into the interplay of molecular chirality and the formation of macroscopic, self-assembled helices. They also exhibit unique optical properties, in particular huge polarization rotation, which is employed in a wide range of photonic technologies. Here, we present a study of linear and circular optical birefringence in combination with X-ray diffraction experiments on an archetypical ChLC, i.e., the cholesteric ester CE6, confined in cylinders of mesoporous alumina and silica with distinct polymer surface graftings resulting in normal or tangential wall anchoring. The unconfined ChLC exhibits a discontinuous, first-order isotropic-to-chiral nematic (cholesteric) phase transition with the formation of double-twist helices and a discontinuous cholesteric-to-smectic A transition. The thermotropic behavior of the confined ChLC, explored in a channel radii range of 7–21 nm, deviates substantially from bulk behavior. There is no isotropic state. In contrast, a chiral paranematic phase with a preferred arrangement of the ChLC at the channel wall is found. For normal anchoring, a radial-escape structure evolves upon cooling. The phase transition to the smectic phase is completely suppressed. For tangential anchoring, a large optical activity indicates a continuous paranematic-to-cholesteric transition with double-twist helices aligned parallel to the long axes of the cylinders. Upon cooling, these helical structures, known as basic building blocks of blue ChLC phases, transform in a continuous manner to a cylinder-aligned smectic A phase.
Distributed sequential computing using mobile code: Moving computation to data (2001)

Sequential computations can benefit from a distributed environment consisting of a network of workstations through the use of a mobile agent system. We found significant performance improvement when sequential algorithms for solving large industrial problems are implemented using mobile agents. This is because raw data is distributed so that the cost of disk paging is completely eliminated, and a principle of "code moving to data" is followed to achieve efficient communication through the network. We argue that mobile agent systems provide a new level of abstraction in which application programming is made easier because the sequential algorithms remain essentially unchanged in mobile agent code.
Access control and content authentication for hybrid DVB-T2/P2P broadcasting (2011)

Considering the large amounts of data to be processed when distributing 3D audio-visual content, it is reasonable to combine broadcasting and P2P distribution, an approach that has been chosen within the EU project DIOMEDES. Two issues to be solved within such a scenario are related to security: Access control, to support business models where only authorized receivers can access certain content, and content authentication, to avoid distribution of unauthorized and corrupted content. This paper describes how access control and content authentication have been addressed within DIOMEDES, including evaluation of different broadcast encryption schemes with respect to the requirements of the hybrid DVB-T2/P2P distribution scenario. The presented approach is agnostic with respect to both the content format and the P2P network used, and can also be adapted to other, similar scenarios.
Southern Blot Detection of Human Papillomaviruses (HPVs) DNA Sequences in Gingival Tissues (1992)

The highly sensitive and specific methods of molecular biology emphasize the frequency of subclinical infections in the genital tract tissues by the human papillomaviruses (HPVs). The purpose of this work was to investigate occult viral infections by the HPV type 6, 11, 16, and 18 in the gingival tissues. The Southern blot method with 32P-radiolabeled DNA probes applied under stringent conditions to 20 interproximal gingival papilla specimens revealed homologous viral sequences in 1 of 6 cases of adult periodontitis (HPV 16), 1 of 2 cases of rapidly progressive periodontitis (RPP) (HPV 6/HPV 11), 2 of 2 cases of acute gingivitis in psychiatric institutionalized patients (HPV 6; HPV 6/HPV 11), and 2 of 10 cases of acute gingivitis in AIDS patients (HPV 6/HPV 11/HPV 16; HPV 6). No periodontal or extra-periodontal specimen hybridized with the HPV 18 probe. Simultaneous hybridization with two or three HPV types was common (3/6 cases). The present detection of HPV 6, 11, 16 DNAs or related-DNAs in periodontal tissues without obvious clinical signs of viral infection suggests that the gingival epithelium may act as a reservoir.
Supplementary Figures from A Prospective Analysis of Circulating Plasma Metabolites Associated with Ovarian Cancer Risk (2023)

&lt;p&gt;Supplementary Figures 1-8&lt;/p&gt;
Fiber-optical long-distance telecommunication line operating at the wavelength of 1.3 μ (1978)

A 2-km fiber-optical telecommunication line was investigated. Specially developed new semiconductor heterolasers, emitting at the wavelength of 1.3 μ, and low-loss optical fibers were used in this line. The energy characteristics of the new lasers were found to be suitable for data transmission over tens of kilometers.
Quantitative Linear Dichroism Imaging of Molecular Processes in Living Cells Made Simple by Open Software Tools (2020)

<title>Abstract</title> Fluorescence-detected linear dichroism microscopy allows observing various molecular processes in living cells, as well as obtaining quantitative information on orientation of fluorescent molecules associated with cellular features. Such information can provide insights into protein structure, aid in development of genetically encoded probes, and allow determinations of lipid membrane properties. However, quantitating and interpreting linear dichroism in biological systems has been laborious and unreliable. Here we present a set of open source ImageJ-based software tools that allow fast and easy linear dichroism visualization and quantitation, as well as extraction of quantitative information on molecular orientations, even in living systems. The tools were tested on model synthetic lipid vesicles, and applied to a variety of biological systems, including observations of conformational changes during G-protein signaling in living cells, using fluorescent proteins. Our results show that our tools and model systems are applicable to a wide range of molecular systems and polarization-resolved microscopy techniques, and represent a significant step towards making polarization microscopy a mainstream tool of biological imaging.
Combined Tamoxifen and Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Versus LHRH Agonist Alone in Premenopausal Advanced Breast Cancer: A Meta-Analysis of Four Randomized Trials (2001)

The combination of LHRH agonist plus tamoxifen is superior to LHRH agonist alone in premenopausal women with advanced breast cancer. Therefore, if a premenopausal woman with advanced breast cancer is thought to be suitable for endocrine treatment, it is proposed that the combination of a LHRH agonist plus tamoxifen be considered as the new standard treatment.
Synthesis of a tricyclic lactam via Beckmann rearrangement and ring-rearrangement metathesis as key steps (2015)

A tricyclic lactam is reported in a four step synthesis sequence via Beckmann rearrangement and ring-rearrangement metathesis as key steps. Here, we used a simple starting material such as dicyclopentadiene.
A method to verify the continuance of check varieties in multilocation yield trials - a case study in wheat. (2010)

Three statistical tools, namely relative yield, yield responsiveness and Eberhart and Russel's parameters, were used for assessing the performance of three wheat check varieties used for evaluation of coordinated multilocation yield trials. Relative yield indices over locations and over years revealed that the check HD2687 was the most stable one, while PBW343 showed above optimum performance and HD2329 showed below optimum performance. In responsiveness for yield, HD2687 showed stable responsiveness, while PBW343 showed higher responsiveness and HD2329 recorded low responsiveness. The study revealed that among the three check cultivars, HD2329 may be removed as a check due to its low yield performance, while HD2687, showing desirable features of responsiveness along with yield stability and PBW343 having high responsive attributes, should be continued as checks in the years to come. The continuance of check cultivars for multilocation yield testing should be based on the relative yield stability and responsiveness characteristics.
On the origin of amniotic stem cells: of mice and men (2010)

A common characteristic of mammals is the development of extraembryonic supporting tissues and organs that are required for embryonic implantation, survival and development in utero. The amnion is the innermost extraembryonic membrane that eventually surrounds the fetus of amniotes, and contains the amniotic fluid. Next to its function in in utero development, the amnion has been shown to have an important potential for clinical applications. It is mainly used as a dressing to stimulate healing in skin and ocular wounds. Moreover, cells derived from the amniotic membrane and amniotic fluid have been reported to possess stem cell features, like pluripotent differentiation ability. Little is known about the early development of this membrane in humans. The mouse is a powerful genetic model organism that can be used to address the dynamics and the developmental origin of amnion and amnion-derived stem cells. Here, we discuss some fundamental differences in amnion development in the disc-shaped primate embryo and in the cup-shaped mouse embryo. We emphasize the consequences that this may have on the derivation of amniotic "stem" cells. After revision of the different isolation procedures of amniotic (fluid) derived "stem" cells from rodents, we reveal striking differences in the sources used to derive these cells across studies. The profound differences in the development of the extraembryonic membranes and cavities between primates and rodents may result in comparing cell types of different developmental origins, eventually leading to missinterpretations.
Supplementary Figure from Modulation of the Estrogen/erbB2 Receptors Cross-talk by CDK4/6 Inhibition Triggers Sustained Senescence in Estrogen Receptor– and ErbB2-positive Breast Cancer (2023)

Supplementary Figure from Modulation of the Estrogen/erbB2 Receptors Cross-talk by CDK4/6 Inhibition Triggers Sustained Senescence in Estrogen Receptor– and ErbB2-positive Breast Cancer
Lateral lithiation in deep eutectic solvents: regioselective functionalization of substituted toluene derivatives (2020)

The heteroatom-directed lateral lithiation of functionalized toluenes in a choline chloride-based eutectic mixture is reported. The metalations proceed within ultrafast reaction times, with a broad substrate and electrophile scope. The directing groups provide a rapid and high regioselective access to functionalized aromatic derivatives of remarkable synthetic value.
DWT-DCT Based copyright Protection In Ycbcr Color Space (2019)

Digital image watermarking is powerful technique which provide ownership protection and copyright protection. In this paper, a novel watermarking technique based on Discrete Cosine Transform (DCT) and Discrete Wavelet Transform (DWT) is presented. YCbCr color model is used for watermark embedding and extraction because of its close resemblance to human visual system. Single level DWT is applied to Luma Component of YCbCr color cover image and then DCT coefficients are taken for watermark embedding process. DCT is applied block by block of size . Binary watermark is scrambled using Arnold transform with k iterations to achieve robustness. Proposed method has been evaluated by many performance evaluation measures such as Peak Signal to Noise Ratio (PSNR), Normalized Correlation (NC) and Computational time. Various watermark attacks are also applied against proposed method, result shows that superiority over other methods.
Results of two Phase 1 multicenter trials of AZD5363, an inhibitor of AKT1, 2 and 3: biomarker and early clinical evaluation in Western and Japanese patients with advanced solid tumors. (2013)

Background: AZD5363 is an oral, potent, and selective inhibitor of AKT1, 2 and 3, with activity in a wide range of tumor cell lines and xenografts dependent upon PI3K/AKT signaling.Methods: Two phase I studies (NCT01226316 [West], NCT01353781 [Japan]) were initiated to define the toxicity, pharmacokinetic (PK), and pharmacodynamic (PD) profile of AZD5363. Two schedules, continuous bid dosing (7/7) and an intermittent schedule bid dosing 4 days on 3 days off (4/7), were investigated. PD biomarkers of AKT signaling were assessed (using pre- and on-treatment samples) in plasma (pPRAS40, pGSK3β, pAKT, glucose, insulin), plucked hair (pPRAS40) and tumor tissue (pPRAS40, pGSK3β, pAKT).Results: At data cut-off (January 2013), 92 patients had been treated in the dose-escalation phases of both studies. In the Western study, the maximum tolerated dose (MTD) for each schedule was 320 mg bid (7/7) and 480 mg bid intermittent dosing (4/7). In the Japanese study, 320 mg bid (7/7) was not tolerated; the MTD for intermittent dosing (4/7) was 480 mg bid. The most commonly reported adverse events, of note, were hyperglycemia, rash, and diarrhea. The PK profile suggests a dose proportional increase in Cmax and AUC. Exposures achieved at doses of 320 mg bid (7/7) and 480 mg bid (4/7) and above are consistent with activity seen in xenograft models. At the doses described, target engagement was seen as evidenced by PD changes in normal tissue (&gt;50% reduction in pPRAS40 in 7/10 patients on AZD5363 480 mg bid (4/7) in plucked hair samples and 30-50% reduction in pPRAS40 and &gt;30% reduction in pGSK3β in platelet rich plasma). Importantly, 7/9 paired biopsies showed an increase in pAKT consistent with the non allosteric inhibition of AKT. Investigation of another intermittent schedule of AZD5363 bid, 2 days on/5 days off treatment, is ongoing. Exploratory mutation analyses of plasma samples are ongoing. Two partial responses were observed, one endometrioid cancer of the ovary and one cervical cancer, in patients on AZD5363 at 480 mg bid (4/7) and 400 mg bid (7/7), respectively. Mutation of either AKT1 or PIK3CA was identified in tumor tissue from both patients. A further patient, with endometrioid cancer of ovary (PIK3CA mutation), had stable disease (SD) for 156 days.Conclusions: AZD5363 administered at 480 mg bid (4/7) was generally well tolerated and showed a PK and PD profile consistent with activity in preclinical models. Partial responses were noted in patients with mutations driving the PI3K pathway.
Redox signaling. (2003)

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have recently been shown to be involved in a multiplicity of physiological responses through modulation of signaling pathways. Some of the specific signaling components altered by reactive oxygen and nitrogen species (RONS) have begun to be identified. We will discuss RONS signaling by detailing the chemistry of signaling, the roles of antioxidant enzymes as signaling components, thiol chemistry in the specificity of RONS signaling, .NO-heme interactions, and some do's and don'ts of redox signal research. The principal points raised are that: (1) as with classic signaling pathways, signaling by RONS is regulated; (2) antioxidant enzymes are essential 'turn-off components in signaling; (3) spatial relationships are probably more important in RONS signaling than the overall 'redox state' of the cell; (4) deprotonation of cysteines to form the thiolate, which can react with RONS, occurs in specific protein sites providing specificity in signaling; (5) although multiple chemical mechanisms exist for producing nitrosothiols, their formation in vivo remains unclear; and (6) caution should be taken in the use of 'antioxidants' in signal transduction.
Abstract 32: The Role of Cyclin A2 in Adult Human Cardiomyocyte Plasticity (2017)

The adult mammalian heart is known to have a very low abundance of progenitor cells which can take part in active cycling and regeneration after damage. Cardiomyocytes exit the cell cycle soon after birth coincident with the silencing of cyclin A2 (CCNA2). In our previous studies, we demonstrated that viral delivery of Ccna2 induces cardiac regeneration in infarcted hearts of small and large animal models. However, the molecular mechanism whereby Ccna2 induces cardiac regeneration and increase in cardiac function deserves further study. To explore further, we isolated adult mouse cardiomyocytes and induced Ccna2 expression by using adenovirus transfection and cultured them for 3 weeks. Co-expression of the mature cardiac marker troponin Tc with the immature cardiac marker non-muscle myosin IIB was observed. Additionally, expression of epithelial to mesenchymal transition markers (vimentin and FSP1) was observed. Also, decreased expression of mature cardiac markers α-MHC , ckmt2 and cTnT was noted. To study the factors responsible for human cardiomyocyte plasticity and cell division, we have optimized a novel method for culturing adult human cardiomyocytes in our laboratory. We cultured cardiomyocytes isolated from heart tissue obtained from a 55 yr old male patient. After transfection with CCNA2 adenovirus made for human use (cTnT promoter driving human CCNA2 cDNA), they were co-transfected with two more adenoviruses (1) cTnT-GFP to label cardiomyocytes (green) and (2) CMV-α-actinin-m-Cherry to label the sarcomere (red). Time lapse live epifluorescence microscopy was carried out for 70 hrs and time lapse movies were prepared (please refer the youtube link to see a representative time lapse movie https://youtu.be/OBrJGCq7YCA ). Movies were analyzed to calculate the cytokinesis index in samples transfected with (Test) and without (Null) CCNA2 adenoviruses. We observed a significantly higher cytokinesis index in CCNA2 samples versus Null. We are further investigating the role of cyclin A2 in dedifferentiation of adult human cardiomyocytes to generate immature or progenitor cardiac cells and their contractile status, which could be utilized for regeneration and functional restoration of damaged adult heart tissue.
Temperature Dependence of Lamellar Thickness in Isothermally Crystallized Poly(butylene terephthalate) (2016)

In order to clarify the crystallization from the melt in poly(butylene terephthalate) (PBT), the heating processes of isothermally crystallized PBT have been investigated by differential scanning calorimetry (DSC), wide-angle X-ray diffraction, and small-angle X-ray scattering. Both the melting temperature and the crystallization temperature dependences of the lamellar thickness show two distinct regions separated by 208 °C, which indicate two equilibrium transition temperatures, 270 and 335 °C. On the basis of the proposed crystallization model, it is interpreted that the crystallization proceeds through the mesophase below 208 °C and directly from the melt above 208 °C. The experimental results also show the constant excess length of lamella over the experimental temperature range.
Supramolecular Stabilization of N2H7+ (2002)

The cation N(2)H(7)(+) has been stabilized in a largely hydrophobic supramolecular environment and characterized in the solid state. The cation is situated in the bowl-shaped cavity of calix[4]arene. All of the hydrogen atoms are clearly discernible owing to high-quality X-ray data as well as lack of disorder and symmetry-imposed ambiguity. It appears that electrostatic interactions play a critical role in stabilizing the structure.
Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of <i>Magnolia officinalis </i> (2011)

Magnolol and honokiol, main active compounds from the bark of Magnolia officinalis, have been found to have various pharmacological actions, including anti-oxidative, anti-inflammatory, anti-tumor, and anti-microbial properties, without appreciable toxicity. Recently, the anti-tumor activity of magnolol and honokiol has been extensively investigated. Magnolol and honokiol were found to possess anti-tumor activity by targeting the apoptosis pathways, which have been considered as targets for cancer therapies. This review will focus on the mechanisms by which magnolol and honokiol act on apoptosis pathways in cancer that have been characterized thus far, including the death receptor mediated pathway, mitochondria-mediated pathway, caspase-mediated common pathway, and regulation of apoptosis-related proteins. These breakthrough findings may have important implications for targeted cancer therapy and modern applications of traditional Chinese medicine.
Pathological features of IgG4-related sclerosing disease (2010)

Sclerosing lymphoplasmacytic inflammation at almost any site can represent a manifestation of IgG4-RSD. There are several histologic features that can suggest the diagnosis. Immunohistochemistry for IgG4 is a useful diagnostic test to further support the diagnosis.