gebhart/patrepeval huggingface dataset:
Seven-Membered Heterocycles. I. Synthesis of Benzo[b]thiepin 1,1-Dioxide and 1-Phenylsulfonyl-4-phenyl-1,3-butadiene (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeven-Membered Heterocycles. I. Synthesis of Benzo[b]thiepin 1,1-Dioxide and 1-Phenylsulfonyl-4-phenyl-1,3-butadieneVINCENT J. TRAYNELIS and RICHARD F. LOVECite this: J. Org. Chem. 1961, 26, 8, 2728–2733Publication Date (Print):August 1, 1961Publication History Published online1 May 2002Published inissue 1 August 1961https://pubs.acs.org/doi/10.1021/jo01066a027https://doi.org/10.1021/jo01066a027research-articleACS PublicationsRequest reuse permissionsArticle Views260Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Click here for mental health support: Extending mental health services to the isolated learner, Part 2 (2017)

In Part One of this two‐part series ( see the March 2017 issue ), the authors discussed a pilot program to provide telemental health services to the University of Wyoming's distance learners. Among the first of its kind in the United States, the program is intended to offer telemental health services to distance learners that are similar to those provided to on‐campus students. Distance students are typically nontraditional learners, including older adults who may be returning to school to up skill or returning servicemen and ‐women seeking to finish a degree.
Syndromes associated with mitochondrial DNA depletion (2014)

Mitochondrial dysfunction accounts for a large group of inherited metabolic disorders most of which are due to a dysfunctional mitochondrial respiratory chain (MRC) and, consequently, deficient energy production. MRC function depends on the coordinated expression of both nuclear (nDNA) and mitochondrial (mtDNA) genomes. Thus, mitochondrial diseases can be caused by genetic defects in either the mitochondrial or the nuclear genome, or in the cross-talk between the two. This impaired cross-talk gives rise to so-called nuclear-mitochondrial intergenomic communication disorders, which result in loss or instability of the mitochondrial genome and, in turn, impaired maintenance of qualitative and quantitative mtDNA integrity. In children, most MRC disorders are associated with nuclear gene defects rather than alterations in the mtDNA itself.The mitochondrial DNA depletion syndromes (MDSs) are a clinically heterogeneous group of disorders with an autosomal recessive pattern of transmission that have onset in infancy or early childhood and are characterized by a reduced number of copies of mtDNA in affected tissues and organs. The MDSs can be divided into least four clinical presentations: hepatocerebral, myopathic, encephalomyopathic and neurogastrointestinal. The focus of this review is to offer an overview of these syndromes, listing the clinical phenotypes, together with their relative frequency, mutational spectrum, and possible insights for improving diagnostic strategies.
What is the recommended approach to asymptomatic patients who develop a reactive PPD? (2006)

Clinical evaluation and chest x-ray are recommended for asymptomatic patients with a positive purified protein derivative (PPD) test result, to exclude the slight possibility of active tuberculosis (TB). Patients with radiographic evidence of old (healed) TB infection should also undergo sputum testing (strength of recommendation [SOR]: C, expert opinion). Treatment with isoniazid (INH) monotherapy (300 mg/d) reduces progression of latent tuberculosis to active disease (SOR: A, large randomized controlled trials [RCT]), with 9 months as the optimal treatment length (SOR: B, derivation from RCTs). A 3-month course of combined rifampin (600 mg/d) and INH (300 mg/d) is equivalent in efficacy to INH monotherapy and is associated with similar rates of toxicity (SOR: A, meta-analysis of RCTs), but this regimen is not included in Centers for Disease Control and Prevention recommendations.
Caprice-Revue. Avant la norme. (2008)

Our results demonstrated that the HPV16-E6E7-DNA compound might become a candidate for HPV16 precautionary and immunotherapy.
Studies on cyclohexane derivatives. Part VIII: Preparation and mass spectra of the seven t‐butylcyclohexanecarboxylic acids (1970)

Abstract 1‐ t ‐Butylcyclohexanecarboxylic acid ( 1 ) has been synthesized from t ‐butyl‐cyclohexanols as well as from 2‐(1‐methylcyclohexyl)‐2‐propanol by the Koch ‐Haaf carboxylation. A side product in these preparations is 2‐methyl‐2‐(1‐methylcyclohexyl)propionic acid ( 5 ). Details are given for the preparation of the cis ‐ and trans ‐isomers of 2‐, 3‐and 4‐ t ‐butylcyclohexanecarboxylic acid ( cis ‐ and trans ‐ 2, 3 and 4 ) starting from the corresponding t ‐butylbenzoic acids. The t ‐butylbenzoic acids and their methyl esters have been hydrogenated over transition metal catalysts at 25°. Palladium differs from platinum, rhodium and ruthenium by, in all cases, giving in excess the most stable isomer. In the hydrogenation of 2‐ t ‐butylbenzoic acid over rhodium desorbed 6‐ t ‐butyl‐1‐cyclohexene‐1‐carboxylic acid is shown to be the main source of the trans ‐ 2 formed. The mass spectra of 1 − 4 are presented and discussed. The mode of fragmentation of cis ‐ 4 and cis ‐ 3 was found to differ in a characteristic way from that of their trans ‐isomers.
Serum alkaline phosphatase is a predictor of mortality, myocardial infarction, or stent thrombosis after implantation of coronary drug-eluting stent (2012)

Our study demonstrated that the higher serum ALP level is an independent predictor of mortality, myocardial infarction, and stent thrombosis in CAD patients after PCI with DES.
The remarkable incircle of a triangle (2001)

The incircle of a triangle is that circle which just touches all three sides of the triangle. Figure 1 shows the incircle for a triangle. It is easy to see that the center of the incircle (incenter) is at the point where the angle bisectors of the triangle meet. In this note we refer to a right triangle in which all three sides are relatively prime as a
The quantized Hall insulator in the presence of resistance fluctuations (2002)

We present an experimental study of mesoscopic, two-dimensional electronic systems at high magnetic fields. Our samples, prepared from a low-mobility InGaAs/InAlAs wafer, exhibit reproducible, sample specific, resistance fluctuations. Focusing on the lowest Landau level we find that, while the diagonal resistivity displays strong fluctuations, the Hall resistivity is free of fluctuations and remains quantized at its $\nu=1$ value, $h/e^{2}$. This is true also in the insulating phase that terminates the quantum Hall series. These results extend the validity of the semicircle law of conductivity in the quantum Hall effect to the mesoscopic regime.
Supplementary Figure 1 from Evolutionary Action Score of <i>TP53</i> Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients (2023)

&lt;p&gt;Supplementary Figure 1: Expression of p53 target genes is impaired following cisplatin treatment in HNSCC harboring mutant TP53.&lt;/p&gt;
Structure of a bifunctional organic reagent: 2,2'-bis(dimethylaminomethylene)-2,2'-sulfonyldiacetonitrile (1987)

The title compound (Ia) was prepared as a potential cross-linking reagent for hemoglobin. CIoHI4N402S, Mr=254.31, monoclinic, P2Jn, a= 14.335 (6), b = 7.614 (4), c = 24.36 (1) A, fl= 107.54 (3) °, v= 2534 (2) A 3, z = 8, Dx= 1.33 g cm -3, 2(Mo Ks) = 0.71069 A, /1 = 2.41 cm -~, F(000) = 1072, T= 295 K. Final R = 0.051 for 2350 observed reflections. There are two independent mole- cules with different conformations. The bond distances to the central S atom are: S-O= 1.43 (3) and S-C = 1.75 (4)A. The observed bond lengths 01- S-CTC 4 and O2-S-C~-C 2 are compatible with a resonance hybrid structure which has bond delocaliza- tion over all atoms between the terminal amino N atoms, giving the molecule an anionic character. The distance between the potential cross-linking sites (5.680 A) is in the range required. Introduction. One of our current projects involves chemical modification of cell-flee hemoglobins for potential use as substitutes for blood in emergency transfusion. The need for such an alternative is becoming increasingly pressing in view of the scarcity of blood especially when rare types are needed, and the possible transmission of diseases such as AIDS or hepatitis associated with blood transfusion. Our aim is to exploit the abundantly available and the relatively inexpensive human and bovine hemoglobins as an alternative to blood for a cell-free oxygen carrier (for recent advances in this area, see Bolin, Beyer & Nemo (1983)). To this end, however, two major problems inherent in cell-free hemoglobins need be overcome: first, the retention time of the cell-flee hemoglobins is short such that most of the infused hemoglobin is quickly eliminated from the circulating blood and, second, the oxygen-binding affinity for cell-free hemoglobins is too
Subchondral screw abutment: does it harm the joint cartilage? An in vivo study on sheep tibiae (2017)

In conclusion subchondral screw abutment did not damage the joint cartilage after a two- and four-month follow up in this sheep model.
Effects of amniotic membrane on epithelial wound healing and stromal remodelling after excimer laser keratectomy in rabbit cornea (2001)

Use of the AM as a dressing on a corneal wound created by excimer laser surgery, in which severe haze is expected, may induce rapid epithelial healing with less inflammatory response. The AM may inhibit the irregular synthesis of stromal collagen that is associated with corneal haze.
A prospective assessment of the Garren-Edwards Gastric Bubble and bariatric surgery in the treatment of morbid obesity. (1990)

Morbid obesity is a serious medical hazard, and effective alternatives to surgery have been unsuccessful. In 1985, the Garren-Edwards Gastric Bubble (GEGB) was offered as an adjunct to dietary and behavioral therapy for weight loss treatment. The safety and efficacy of the GEGB were compared with bariatric surgery, the current standard for the treatment of morbid obesity. Fifty-seven patients received GEGB and 77 underwent bariatric surgery. GEGB patients were divided into two groups: those who attended group therapy and those who did not. This study showed that bariatric surgery was far more effective in reducing excess body weight during a 12-month period compared with the GEGB plus group therapy and the GEGB alone. The morbidity from bariatric surgery was greater than in the GEGB-treated groups, while the cost for uncomplicated cases for a year's treatment was comparable. It is concluded that the GEGB does not offer an effective alternative to bariatric surgery in the treatment of morbid obesity.
Synthesis of Ethyl 1-Phenyl- and 2-Methyl-6H-furo[2,3-d][1]benzazepine-5-carboxylates (1977)

Thermolysis of ethyl a -a z i d o -B -( 3 -p h e n y l f u r y l -2 ) - acrylates (la,b) in ligroin gave ethyl 1-phenyl-or
High Resolution Electron Microscopy of Crystal and Defect Structures of the High-Tc Superconductor Ba2YCu3O7-δ (1987)

Structural study of the superconducting oxide Ba 2 YCu 3 O 7-δ has been made at room temperature by high resolution electron microscopy. The orthorhombic structure was confirmed by the direct imaging of metal atoms. Planar defects with stacking sequence of metal-oxygen planes in the La 2 CuO 4 type of structure were observed. Depending on the selected arca in electron diffraction, the axial ratio b / a was found to vary in a range from 1.003 to 1.018. Black and white contrasts appearing alternately along the twin boundaries are discussed in relation to the lattice distortion and the oxygen deficiency in the Cu-O layer.
Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor (2018)

Type 1 cannabinoid receptor (CB1) antagonists have demonstrated promise for the treatment of obesity, liver disease, metabolic syndrome, and dyslipidemias. However, the inhibition of CB1 receptors in the central nervous system can produce adverse effects, including depression, anxiety, and suicidal ideation. Efforts are now underway to produce peripherally restricted CB1 antagonists to circumvent CNS-associated undesirable effects. In this study, a series of analogues were explored in which the 4-aminopiperidine group of compound 2 was replaced with aryl- and heteroaryl-substituted piperazine groups both with and without a spacer. This resulted in mildly basic, potent antagonists of human CB1 (hCB1). The 2-chlorobenzyl piperazine, 25, was found to be potent ( K<sub>i</sub> = 8 nM); to be >1000-fold selective for hCB1 over hCB2; to have no hERG liability; and to possess favorable ADME properties including high oral absorption and negligible CNS penetration. Compound 25 was tested in a mouse model of alcohol-induced liver steatosis and found to be efficacious. Taken together, 25 represents an exciting lead compound for further clinical development or refinement.
Structural basis of ATP-dependent high-fidelity epigenome maintenance (2021)

SUMMARY Epigenetic evolution occurs over million-year timescales in Cryptococcus neoformans and is mediated by DNMT5, the first maintenance-type cytosine methyltransferase identified in the fungal or protist kingdoms. DNMT5 requires ATP and displays exquisite hemimethyl-DNA specificity. To understand these novel properties, we solved cryo-EM structures of Cn DNMT5 in three states. These studies reveal an elaborate allosteric cascade in which hemimethylated DNA first activates the SNF2 ATPase domain by a large rigid body rotation while the target cytosine partially flips out the DNA duplex. ATP binding then triggers a striking structural reconfiguration of the methyltransferase catalytic pocket that enables cofactor binding, completion of base-flipping, and catalysis. Unmethylated DNA binding fails to open cofactor pocket and subsequent ATP binding triggers its ejection to ensure fidelity. This chaperone-like, enzyme-remodeling role of the SNF2 domain illuminates how energy can be used to enable faithful epigenetic memory. Highlights Structures of DNMT5 reveal mechanism of ATP-dependent DNA methylation Hemimethylated CpG recognition triggers partial base flipping of the target cytosine Hemimethylated DNA induces rigid body rotation to activate the SNF2 ATPase domain MTase catalytic pocket is remodeled by the SNF2 ATPase to achieve specificity
Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders (2022)

Therapeutic aryl hydrocarbon receptor (AHR) modulating agents gained attention in dermatology as non-steroidal anti-inflammatory drugs that improve skin barrier properties. By exploiting AHR's known ligand promiscuity, we generated novel AHR modulating agents by lead optimization of a selective AHR modulator (SAhRM; SGA360). Twenty-two newly synthesized compounds were screened yielding two novel derivatives, SGA360f and SGA388, in which agonist activity led to enhanced keratinocyte terminal differentiation. SGA388 showed the highest agonist activity with potent normalization of keratinocyte hyperproliferation, restored expression of skin barrier proteins and dampening of chemokine expression by keratinocytes upon Th2-mediated inflammation in vitro. The topical application of SGA360f and SGA388 reduced acute skin inflammation in vivo by reducing cyclooxygenase levels, resulting in less neutrophilic dermal infiltrates. The minimal induction of cytochrome P450 enzyme activity, lack of cellular toxicity and mutagenicity classifies SGA360f and SGA388 as novel potential therapeutic AHR ligands and illustrates the potential of medicinal chemistry to fine-tune AHR signaling for the development of targeted therapies in dermatology and beyond.
Optical measurement of target displacement and velocity in bird strike simulation experiments (2002)

Thousands of bird strikes on aircraft occur annually with subsequent consequences for repair costs but also for public safety. In bird strike simulation experiments a bird or birdlike object is usually accelerated towards a target. Knowledge of the parameters of the impact, such as the velocities involved, the target displacement and the energy transferred from the projectile to the target, lead to a better understanding of the phenomenon, and eventually to better protection against damage caused by bird strikes.
Floor Scale Modulo Lifting for QC-LDPC codes (2017)

In the given paper we present a novel approach for constructing a QC-LDPC code of smaller length by lifting a given QC-LDPC code. The proposed method can be considered as a generalization of floor lifting. Also we prove several probabilistic statements concerning a theoretical improvement of the method with respect to the number of small cycles. Making some offline calculation of scale parameter it is possible to construct a sequence of QC-LDPC codes with different circulant sizes generated from a single exponent matrix using only floor and scale operations. The only parameter we store in memory is a constant needed for scaling.
Effect of diet and method of feeding on performance of pigs weaned at three weeks of age (1981)

Four trials involving 600 pigs weaned at 15 to 23 days were conducted to evaluate pig performance as affected by added whey and method of feeding during the first week after weaning. Pigs fed 20% dried whole whey gained faster the first two weeks after weaning and during the 35-day trial than did pigs fed a milo-soybean meal diet with no whey. Ten percent dried whole whey did not improve performance over that of the control diet, and 30% dried whey showed no advantage over the 20% whey diet. Pigs fed delactosed whey substituted on a protein basis for 20% dried whole whey performed the same as those fed 20% whole whey. Adding lactose to the basal diet did not improve pig performance. Pigs fed the 20% whey diet for the first two weeks and the control diet for the last three weeks of the trial performed similar to those fed the 20% whey diet during the entire 35-day trial. By feeding a whey diet for only two weeks, total cost of gain is greatly decreased.; Swine Day, Manhattan, KS, November 12, 1981
A Powerful and Sensitive Gauge for Plasma-Process-Induced Damage in Differential Amplifier Circuit Design (2003)

Plasma-process-induced damage (PPID) in the semiconductor process is a common phenomenon influencing gate-oxide reliability and circuit performance. How to reduce this effect to an acceptable level is a key issue in recent semiconductor manufacturing. In this paper, a differential amplifier circuit plus designed antenna test patterns to powerfully detect this plasma impact on gate-oxide integrity is proposed. In circuit simulation, the degree of the charging effect in the process from a different back-end metal or via layers on gate-oxide reliability can be effectively gauged. This valuable information can be returned to the process engineers to optimally adjust the plasma process if certain circuit products request a precise and excellent device performance.
Alumina nanofibers obtained from poly(vinyl alcohol)/boehmite nanocomposites (2011)

Abstract Poly(vinyl alcohol) (PVA)/boehmite nanocomposite (precursor) nanofibers were formed by electrospinning using a PVA aqueous solution of dispersed boehmite nanoparticles as the spinning solution. The alumina nanofibers were obtained by calcination of the precursor nanofibers between 500 and 1200°C. The specific surface area of the precursor nanofibers was around 6 m 2 /g, and that of the γ‐alumina nanofibers calcined at 500°C was around 300 m 2 /g. The specific surface areas and the fiber diameters were not affected by the alumina contents in the precursors. Also, the diameter of the alumina nanofibers was not affected by the calcination temperature of the precursor nanofibers. The pore characteristics of the alumina nanofibers decreased with increased calcination temperature due to the sintering, and nonporous α‐alumina nanofibers were obtained by calcination of the precursor nanofibers at 1200°C. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
A New Hydrosilylation Mechanism—New Preparative Opportunities (2004)

One up in limiting reactivity: The monosubstitution of multifunctional molecules is a general problem in synthetic chemistry. The catalyst [Cp*(PiPr3)(H)2RuSi(H)Ph⋅Et2O][B(C6F5)4] (Cp*=η5-C5Me5) can be used for the alkylation of phenylsilane PhSiH3 with simple olefins. The reaction stops at the monoalkylation level to give PhSi(Alk)H2 (see scheme; R=H, C6H5, C4H9).
‘Polymorphism’ in a novel anti-viral agent: Lamivudine (1997)

Two modifications of Lamivudine have been studied. One has a highly symmetrical crystal lattice and the other, unusually, an asymmetric unit containing five non-equivalent molecules (with some disorder). The latter contains one molecule of water for every five of Lamivudine. Solid-state NMR spectra reflect these dramatic differences and the technique has been used to predict the extent of the asymmetry in the latter form. X-Ray diffraction studies confirm the differences in symmetry between the two polymorphs, which have also been characterised by IR spectroscopy and differential scanning calorimetry.
ChemInform Abstract: Stability and Structure of Benzene Dimer Cation (C6H6)+ 2 in the Gas Phase. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Digital Television Broadcasting: Issues for Successful Implementation (1994)

In considering the issues for successful implementation of Digital Terrestrial Television Broadcasting, we can draw on a foundation of NTL's experience as the provider of the NTL 2000 digital video compression system world-wide, and over five years of study on the SPECTRE project in the United Kingdom. SPECTRE is concerned with all aspects of Digital Television including the low-bit rate video coding, modulation, frequency planning, and perhaps most important, practical field trials. The work was initiated under the Independent Broadcasting Authority, but since the IBA was abolished in 1990, it has been carried out by NTL, under contract from the Independent Television Commission in the UK.