gebhart/patrepeval huggingface dataset:
Localization of wireless sensors using compressive sensing for manifold learning (2009)

In this paper, a novel compressive sensing for manifold learning protocol (CSML) is proposed for localization in wireless sensor networks (WSNs). Intersensor communication costs are reduced significantly by applying the theory of compressive sensing, which indicates that sparse signals can be recovered from far fewer samples than that needed by the Nyquist sampling theorem. We represent the pair-wise distance measurement as a sparse matrix. Instead of sending full pair-wise measurement data to a central node, each sensor transmits only a small number of compressive measurements. And the full pair-wise distance matrix can be well reconstructed from these noisy compressive measurements in the central node, only through an ¿ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -minimization algorithm. The proposed method reduces the overall communication bandwidth requirement per sensor such that it increases logarithmically with the number of sensors and linearly with the number of neighbors, while achieves high localization accuracy. CSML is especially suitable for manifold learning based localization algorithms. Simulation results demonstrate the performance of the proposed protocol on both the localization accuracy and the communication cost reduction.
Addressing Therapeutic Options for Ebola Virus Infection in Current and Future Outbreaks (2015)

Ebola virus can cause severe hemorrhagic disease with high fatality rates. Currently, no specific therapeutic agent or vaccine has been approved for treatment and prevention of Ebola virus infection of humans. Although the number of Ebola cases has fallen in the last few weeks, multiple outbreaks of Ebola virus infection and the likelihood of future exposure highlight the need for development and rapid evaluation of pre- and postexposure treatments. Here, we briefly review the existing and future options for anti-Ebola therapy, based on the data coming from rare clinical reports, studies on animals, and results from in vitro models. We also project the mechanistic hypotheses of several potential drugs against Ebola virus, including small-molecule-based drugs, which are under development and being tested in animal models or in vitro using various cell types. Our paper discusses strategies toward identifying and testing anti-Ebola virus properties of known and medically approved drugs, especially those that can limit the pathological inflammatory response in Ebola patients and thereby provide protection from mortality. We underline the importance of developing combinational therapy for better treatment outcomes for Ebola patients.
Suppression of TNF-alpha production in human mononuclear cells by an adenosine kinase inhibitor. (2000)

Adenosine exerts potent anti-inflammatory activities through inhibition of cytokine synthesis by activated monocytes. Adenosine is rapidly phosphorylated intracellularly by adenosine kinase. GP515, an adenosine kinase inhibitor, prevents the phosphorylation of adenosine to AMP and thereby locally enhances the adenosine concentration. GP515 has exhibited significant anti-inflammatory effects in several murine models of inflammation. In this study we investigated the effect of GP515 alone and in combination with exogenous adenosine or with rolipram, a phosphodiesterase inhibitor, on tumor necrosis factor alpha (TNF-alpha) synthesis in human peripheral blood mononuclear cells (PBMC) or whole blood. Lipopolysaccharide (LPS; 10 ng/mL)-stimulated PBMC were incubated in the absence or presence of these substances. GP515 alone showed a dose-dependent suppression of TNF-alpha production with an IC50 of 80 microM. The TNF-alpha-inhibiting effects of adenosine and GP515 were reversed in the presence of the cAMP antagonist (Rp)-cAMPS, supporting the hypothesis of a cAMP-mediated pathway. Combinations of GP515 with either adenosine or rolipram led to an additive inhibition of TNF-alpha synthesis. These experiments are the first to demonstrate efficacy of an adenosine kinase inhibitor in TNF-alpha suppression in cells of human origin. The findings form a basis to investigate these strategies in animal models of TNF-alpha-mediated chronic inflammatory diseases.
Evaluation of synchronous-rectification efficiency improvement limits in forward converters (1995)

Design trade-offs for different implementations of the forward power converter with synchronous rectifiers are presented, and effects of the synchronous rectifier driving method on the conversion efficiency are evaluated. Specifically, the merits and limitations of the RCD-clamp and active-clamp reset approaches for a power converter with self-driven synchronous rectifiers are discussed. Estimates of the upper limits of the efficiency improvements of the discussed synchronous rectification approaches relative to the Schottky diode implementation are derived. Finally, experimental comparisons of efficiencies for an offline, 3.3 V/20 A forward power converter power stage are presented and compared with the theoretically estimated ones.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Proteome Analysis of Hepatocellular Carcinoma by Two-dimensional Difference Gel Electrophoresis (2007)

Hepatocellular carcinoma (HCC) is a highly malignant tumor, and chronic infection with hepatitis B virus is one of its major risk factors. To identify the proteins involved in HCC carcinogenesis, we used two-dimensional fluorescence DIGE to study the differentially expressed proteins in tumor and adjacent nontumor tissue samples. Samples from 12 hepatitis B virus-associated HCC patients were analyzed. A total of 61 spots were significantly up-regulated (ratio >/= 2, p </= 0.01) in tumor samples, whereas 158 spots were down-regulated (ratio </= -2, p </= 0.01). Seventy-one gene products were identified among these spots. Members of the heat shock protein 70 and 90 families were simultaneously up-regulated, whereas metabolism-associated proteins were decreased in HCC samples. The down-regulation of mitochondrial and peroxisomal proteins in these results suggested loss of special organelle functions during HCC carcinogenesis. Four metabolic enzymes involved in the methylation cycle in the liver were down-regulated in HCC tissues, indicating S-adenosylmethionine deficiency in HCC. Two gene products, glyceraldehyde-3-phosphate dehydrogenase and formimidoyltransferase-cyclodeaminase, were identified from inversely altered spots, suggesting that different isoforms or post-translational modifications of these two proteins might play different roles in HCC. For the first time, the overexpression of Hcp70/Hsp90-organizing protein and heterogeneous nuclear ribonucleoproteins C1/C2 in HCC tissues was confirmed by Western blot and then by immunohistochemistry staining in 70 HCC samples, suggesting their potential as protein tumor markers. In summary, we profiled proteome alterations in HCC tissues, and these results may provide useful insights for understanding the mechanism involved in the process of HCC carcinogenesis.
Sulfur-nitrogen-containing analogs of dibenzo-15-crown-5 as extraction reagents for the selective isolation of mercury (1986)

On the seven sulfur-nitrogen-containing derivatives of dibenzo-15-crown-5 studied, the following are selective reagents with respect to mercury: 2,3:8,9-dibenzo-13-tosyl-4,7-dioxa-1,10,13-triazacyclopentadecane and 2,3:8,9- dibenzo-13-thia-4,7-dioxa-1,10-diazacyclopentadecane (R). The best counter-ions are sulfophthalein dyes. In the presence of an anion (An/sup -/), a compound with ratio Hg:R:An/sup -/=1:1:1 is extracted. An extraction-spectrophotometric method was developed for the determination of mercury directly in the extract by the addition of a solution of dithizon in chloroform. The limit of detection of mercury was 0.04 ..mu..g/ml. The procedure can be used for the determination of mercury in natural waters with a low salt composition.
Megestrol Acetate for the Prevention of Hot Flashes (1994)

Low-dose megestrol acetate is well tolerated and can substantially decrease the frequency of hot flashes in women and men.
The local environment of Dy3+in selenium-rich chalcogenide glasses (2014)

The environment of Dy<sup>3+</sup>is investigated when it is added as DyCl<sub>3</sub>or Dy foil into two base glasses, Ge<sub>16.5</sub>As<sub>19−x</sub>Ga<sub>x</sub>Se<sub>64.5</sub>, where<italic>x</italic>= 3 or 10 at%, at doping levels between 0 and 3000 parts per million by weight (ppmw) Dy<sup>3+</sup>.
Endothelial‐Mesenchymal Transition in Regenerative Medicine (2016)

Endothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneration. As an alternative to traditional or artificial stem cell therapies, EndMT may represent a safe method for engineering new tissues to treat degenerative diseases by mimicking a process that occurs in nature. This review discusses the signaling mechanisms and therapeutic inhibitors of EndMT, as well as the role of EndMT in development, disease, acquiring stem cell properties and generating connective tissues, and its potential as a novel mechanism for tissue regeneration.
A MATHEMATICAL MODEL FOR THE EXTERNAL SCHEDULING OF A CLUSTER TOOL WORKSTATION (2018)

Cluster tools are closed mini production environments that are especially used in the semiconductor industry. They consist of multiple processing chambers. In contrast to single processing tools they can handle multiple lots with different process characteristics at the same time. The major challenge for scheduling cluster tools is the hard to predict process times of even comparable lots as they strongly depend on a changing product mix over the tool. In this paper a mathematical model for the external scheduling of a cluster tool workstation is presented. The goal is to minimize the weighted cycle time by accounting for the changing cycle times of each lot. A MIP model assigns lots to tools of a workstation and determines for each lot the chambers, which are used during the processing steps inside the cluster tool. Finally the developed method is compared with a simulation that uses dispatching strategies.
Endometrial scratching to improve pregnancy rate in couples with unexplained subfertility: A randomized controlled trial (2012)

Endometrial scratching may improve clinical pregnancy rates in couples with unexplained infertility. Adequately powered studies are mandated to confirm or refute the findings.
Identification and Asymptotic Localization of Rumor Sources Using the Method of Types (2019)

We are interested in identifying a rumor source on a tree network. We begin with extended star networks under the SI infection model with exponential waiting times. We present and analyze the types center, a highly tractable approximation of the ML source estimate, obtained using the method of types. We empirically show that this approximate ML estimator is exact for some small test cases. We prove that the approximation error is at most logarithmic in infection size on large networks, providing highly efficient source identification (especially compared to the accuracy in similar problems, such as the O(√n) best possible n accuracy estimate in a line network). We also show that the qualitative properties of the types and rumor centers are different on extended star networks. We further propose a heuristic-based generalization of this approach to trees: the relative-leaf counting algorithm. In simulations on regular and nonregular trees, types center's performance is competitive with rumor centrality (which is optimal for d-regular trees), while requiring less computation time. In addition to providing a faster (and sometimes more accurate) alternative on its own, our approach could potentially be used with rumor centrality to improve results with less than twice the total computation time.
Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene. (1988)

A full-length placental alkaline phosphatase (PLAP) cDNA was used to identify and clone the PLAP-like Nagao isozyme gene from human genomic libraries. The entire nucleotide sequence of the gene reveals the existence of 11 exons interrupted by 10 small introns (76-427 base pairs). Putative regulatory sequences have been identified in the promoter regions as well as dispersed in the introns. The deduced amino acid sequence of the Nagao isozyme indicates that the mature molecule is composed of 513 amino acids, of which 12 residues are different from the sequence of PLAP (98% homology). A sequence derived from exon III of the Nagao isozyme gene was used to synthesize a peptide (NH2-Lys-Leu-Gly-Pro-Glu-Thr-Phe-Leu-Ala-COOH) that contains two mutations with respect to the corresponding PLAP sequence. This peptide elicited rabbit polyclonal antibodies that reacted specifically with the seminoma Nagao isozyme but not with PLAP in electrophoretic transfer blots. These results indicate that the tumor, and possibly the normal testis, Nagao isozyme is encoded by a gene referred to as germ-cell alkaline phosphatase gene that differs from the PLAP gene expressed by syncitiotrophoblastic cells.
Correspondence free 3D statistical shape model fitting to sparse x-ray projections (2010)

In this paper we address the problem of 3D shape reconstruction from sparse X-ray projections. We present a correspondence free method to fit a statistical shape model to two X-ray projections, and illustrate its performance in 3D shape reconstruction of the femur. The method alternates between 2D segmentation and 3D shaoe reconstruction, where 2D segmentation is guided by dynamic programming along the model projection on the X-ray plane. 3D reconstruction is based on the iterative minimization of the 3D distance between a set of support points and the back-projected silhouette with respect to the pose and model parameters. We show robustness of the reconstruction on simulated X-ray projection data of the femur, varying the field of view; and in a pilot study on cadaveric femora.
Subsea Demulsifier Injection to Enhance Crude Oil Production in Offshore Brownfields - A Success Case (2019)

In Brazil oilfield scenario, there are large, clearly identified brownfield sites, many of which with high additional oil production potential. The lifting costs and conventional breakeven price per barrel associated with an existing producing field offshore, even those in decline and requiring some recompletion &amp; workover jobs, are – in many situations - less investiment demanding than brand new greenfield development. The formation of water in oil (W/O) emulsions is ubiquitous in oilfield production. As the water commingled in crude increases, the emulsions' stability and viscosity also increase, thence generating flow restrictions due to higher friction losses. The subsea demulsifier injection has proven to be an interesting alternative to overcome this flowing constraint in mature wells, thus maximizing the productive capacity of existing brownfields. This paper presents some results and challenges faced to implement the routine of subsea demulsifier injection, from the development of testing protocols to come up with a tailor-made chemical solution, to the hurdles associated to chemical injection through subsea umbilical- and gas lift-lines.
Carbene-stabilized main group diatomic allotropes (2011)

While transition metals are well known for assuming the formal oxidation state of zero in various compounds main group elements have rarely engaged in this practice. Recent reports of N-heterocyclic carbene-stabilized main group diatomic allotropes (i.e., Si(2), Ge(2), P(2), As(2)) denote a breakthrough of zero-oxidation state main group chemistry. This Perspective addresses the synthesis and characterization of these highly reactive main group molecules, with a particular emphasis on the very recent progress in the reactivity study of carbene-stabilized Si(2) and P(2).
CTEP #8850: A phase I trial of riluzole and sorafenib in patients with advanced solid tumors. (2015)

11086 Background: Metabotropic glutamate receptor 1 (GRM1) activates MAPK and PI3K/AKT signaling and is implicated in multiple cancers including breast, prostate and melanoma. GRM1 overexpression stimulates tumor angiogenesis via enhanced microvesicle secretion to facilitate endothelial cell growth. Riluzole (R) is a clinically available inhibitor of GRM1 signaling. Sorafenib (S), a kinase inhibitor that inhibits MAPK and PI3K/AKT signaling through C-RAF and B-RAF inhibition with antiangiogenic effects, was identified in preclinical screens to have synergistic antitumor activity when combined with R. This phase I trial identified the maximum tolerated dose (MTD) of R combined with S in patients (pts) with advanced cancer. Methods: Pts with refractory solid tumors were enrolled utilizing a standard 3+3 dose-escalation design. R was given in 28 day cycles at the highest dose used in clinical practice (100 mg BID) in combination with S, beginning at 200 mg daily and escalating in 200 mg increments per cohort. Restaging evaluations were performed every 2 cycles using RECIST criteria. Results: 29 pts enrolled, median age 59 (22-85), 13F, 16M, PS 0 (48%), 1 (35%) or 2 (17%). The most common toxicities were nausea (31%), fatigue (62%) and diarrhea (41%), anorexia (31%), rash (27% PPE, 31% other), and hypophosphatemia (34%). Grade 3-4 toxicities included hypophosphatemia (10%), elevated lipase (10%), LFT abnormalities (10%), rash/PPE (14%), and fatigue (13%). The most frequent dose limiting toxicity (DLT) was rash, observed in 3 pts at the MTD, dose level (DL) 4 (R 200 mg bid/S 400 mg bid). Best responses were SD in 9 pts (31%), lasting > 3 months in 1 pt each with sarcoma, lung, colon, ovarian, and melanoma; and 1 GIST (9+ cycles with modest tumor reduction). Conclusions: R combined with S is safe with DLT of rash. While rash is a known side effect of sorafenib, its incidence and severity appeared increased in this study. An expansion cohort in pts with melanoma and sarcoma at DL3 (R 200 mg bid/S 400mg qam/200 mg qpm) is ongoing. Planned correlative assessments include circulating microvesicle quantification and immunohistochemical and western blotting to assess changes in activated signaling targets in pre and post treatment tumors. Clinical trial information: NCT01303341.
Antigen retrieval techniques in immunohistochemistry: comparison of different methods (1997)

Routine sections of normal and pathological samples fixed in 10 per cent buffered formalin or B5, including EDTA-decalcified bone-marrow biopsies, were tested with 61 antibodies following heating in three different fluids: 0.01 M citrate buffer (pH 6.0), 0.1 M Tris-HCl (pH 8.0), and 1 mM EDTA-NaOH solution (pH 8.0). The sections underwent either three cycles of microwave treatment (5 min each) or pressure cooking for 1-2 min. The alkaline phosphatase/anti-alkaline phosphatase (APAAP) technique was used as the standard detection method; with 16 antibodies a slightly modified streptavidin-biotin complex (SABC)-immunoperoxidase technique was applied in parallel. The results obtained were compared with those observed without any antigen retrieval (AR), or following section digestion with 0.05 per cent protease XIV at 37 degrees C for 5 min. Chess-board titration tests showed that all antibodies but one profited by AR. Protease XIV digestion represented the gold standard for five antibodies, while 55 produced optimal results following the application of heat-based AR. By comparison with the other fluids, EDTA appeared to be superior in terms of both staining intensity and the number of marked cells. These results were independent of tissue processing, immunohistochemical approach, and heating device. Pressure cooking was found to be more convenient on practical grounds, as it allowed the simultaneous handling of a large number of slides and a time saving of 1 min 30 s, representing the proper time for the treatment.
A glucose-dependent spatial patterning of exocytosis in human β cells is disrupted in type 2 diabetes (2019)

Impaired insulin secretion in type 2 diabetes (T2D) is linked to reduced insulin granule docking, disorganization of the exocytotic site, and an impaired glucose-dependent facilitation of insulin exocytosis. We show in β-cells from 80 human donors that the glucose-dependent amplification of exocytosis is disrupted in T2D. Spatial analyses of granule fusion, visualized by total internal reflection fluorescence (TIRF) microscopy in 24 of these donors, demonstrate that these are non-random across the surface of β-cells from donors with no diabetes (ND). The compartmentalization of events occurs within regions defined by concurrent or recent membrane-resident secretory granules. This organization, and the number of membrane-associated granules, is glucose-dependent and notably impaired in T2D β-cells. Mechanistically, multi-channel Kv2.1 clusters contribute to maintaining the density of membrane-resident granules and the number of fusion 'hotspots', while SUMOylation sites at the channel N- (K145) and C-terminus (K470) determine the relative proportion of fusion events occurring within these regions. Thus, a glucose-dependent compartmentalization of fusion, regulated in part by a structural role for Kv2.1, is disrupted in β-cells from donors with type 2 diabetes.
Design guidelines for a novel bandpass distributed amplifier (2005)

In this paper, a new design approach and measured results of a novel, wideband, bidirectional, bandpass distributed amplifier are presented. A prototype bandpass distributed amplifier in the band ranging from 842 MHz to 3.17 GHz has been designed and measured. The distributed amplifier has a nearly constant gain, linear phase response, and acceptable return losses in the passband. The amplifier topology is suitable for monolithic implementation.
Reaction of o-phthalaldehyde and thiols with primary amines: formation of 1-alkyl(and aryl)thio-2-alkylisoindoles (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of o-phthalaldehyde and thiols with primary amines: formation of 1-alkyl(and aryl)thio-2-alkylisoindolesS. Stoney Simons Jr. and David F. JohnsonCite this: J. Org. Chem. 1978, 43, 14, 2886–2891Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/jo00408a030https://doi.org/10.1021/jo00408a030research-articleACS PublicationsRequest reuse permissionsArticle Views1678Altmetric-Citations200LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts