gebhart/patrepeval huggingface dataset:
In situ measurements of cemented paste backfill at the Cayeli Mine (2012)

Cemented paste backfill (CPB) is accepted as the optimal backfilling material for many underground mines. However, the lack of in-stope backfill pressure data poses fundamental problems from both operational and research standpoints. In response to the requirement for in situ data, a comprehensive field instrumentation project has been conducted. Results are presented here for two stopes at the Cayeli Mine, where geotechnical instruments were installed at the barricades and throughout the stopes. Measurements from a large (slow rise rate) stope with high binder content CPB demonstrated a rapid departure from hydrostatic loading, resulting in relatively low barricade pressures. Conversely, data from a smaller (fast rise rate) stope with lower binder content CPB demonstrated that when cement hydration is retarded, high barricade pressures occur. These examples illustrate the relationship between CPB rise rate and the moderating effect of cement hydration on in situ pressures, which ultimately control barricade pressures. Once CPB gains shear strength, arching of pressures occurs. In situ pressures were reduced with proximity to stope walls and further, under stope access brows, demonstrating that barricade location influences barricade loads. The application of real-time pressure monitoring of pastefill barricades has been demonstrated as an important tool in optimizing operational backfilling efficiency.
Triggered insulin release studies of triply responsive supramolecular micelles (2012)

The synthesis of a supramolecular double hydrophilic glucose responsive block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) and poly(acrylamidophenyl boronic acid) (PAAPBA) as temperature and glucose responsive blocks, respectively, and poly(dimethylacrylamide) (PDMAAm) as a hydrophilic block. Drug release studies of insulin-loaded micelles using three external triggers were studied with release of insulin achieved by changing temperature, glucose concentration or by adding a competitive guest for CB[8]. This system offers good control over the release of insulin under physiological conditions (pH 7.4, 37 °C). These exciting results suggest that this system could be a model for a clinically relevant drug delivery vehicle for diabetic treatment.
The β recombinase from theStreptococcalplasmid pSM19035 represses its own transcription by holding the RNA polymerase at the promoter region (1994)

The beta protein encoded by the Streptococcus pyogenes plasmid pSM19035 is a site-specific recombinase involved in both resolution of plasmid multimers into monomers and DNA inversion. It has been proposed that the DNA region to which the beta recombinase binds to mediate recombination includes a promoter from which orf alpha and the beta gene are transcribed. We have determined the sites at which transcription of the orf alpha and the beta gene initiates in vitro and we have demonstrated that highly purified beta recombinase acts as a repressor of its own synthesis. The promoters are located within the beta recombinase binding site, which we have defined previously. The binding of the beta recombinase to its target site does not seem to exclude RNA polymerase from the promoter, despite the overlapping of their binding sites. Therefore, it is likely that the beta recombinase does not repress transcription by a mere steric hindrance on RNA polymerase binding.
A fieldbus prototype for educational purposes (2004)

One of the problems with instrumentation systems is the interconnection between the multiple devices with different communication protocols. Exacerbating this problem are two typical requirements of interconnection: minimize cabling cost and avoid degradation of the signal during transmission. Cabling cost can be reduced through several multidrop communication systems: industrial local area networks or wireless communication. Reduction of signal to noise can restrict system performance and the quality of manufactured products, even if high-accuracy devices are used. Another problem in the field of manufacturing instrumentation networks is that industry uses multiple solutions to interconnect instrumentation with different communication protocols. This article presents the development of a prototype for an instrumentation network with the goal to study and analyze the characteristics of the different communication solutions. The overall system contains a large number of instrumentation devices, which is a great advantage for educational purposes and laboratory experiments. The students can configure, calibrate, and operate a large number of instruments connected to different segments of the DCS. We also connected some current-loop devices to the FF system to evaluate their performance when connected to a fully digital network. Results from the prototype DCS show that networking between different instrumentation devices and protocols can be successful and that a hybrid solution using conventional 4-20 mA current loop and fully digital instrumentation can work to leverage existing analogue systems. Future work will include the development of a fieldbus network analyzer to trace messages in the network and study the quality of FF service parameters, such as packet loss and delay measurement, as a function of network load.
Studies on Ti6Al4V Components Produced by Semi-solid Forming Technology (2015)

Current research activities at the Institute for Metal Forming Technology (IFU) of the University of Stuttgart are focusing on processing high-melting metal materials in the semi-solid state. This forming process is performed in the range between solidus and liquidus line and uses therefore the low materials viscosity in its semi-solid state for realizing complex part geometries. The research work deals with alloy systems based on titanium or cobalt which are widely used in both medical and aerospace technology. In particular, the titanium alloy Ti6Al4 V, possessing high strength, low density and excellent corrosion resistance exactly matches today's lightweight aspirations, and therefore will be of greater importance in the future applications. Due to this favorable combination of properties this alloy nowadays is widely used in technical specialty areas despite its high price. Therefore, many mechanically and thermally highly stressed lightweight components such as turbine blades are designed and manufactured out of this particular titanium alloy. Conventional processes used for such material systems like casting or forging methods usually consume a lot of energy when heating the billet and require increased materials usage, which results in high production-costs. In this context the processing of such materials in the semi-solid state has a great potential in terms of producing complex net-shape or near-net-shape components with good mechanical properties.
The Reactions of Cellulose with Amic Acids and Anhydride /Ammonia (1973)

Reported is the generality of two new, recently reported reactions for the esterification of cellulosic fabrics using amic acids or anhydride/ammonia in aqueous solution. A study is made of amic acid structure and extent of formation of the cellulose half-acid ester, the main reaction product. The formation of crosslinked cellulose, a minor product, is also dis cussed. A series of amic acids, including the isomer pair, maleamic and fumaramic acids, as well as several anhydrides (with ammonia) were reacted with cellulosic fabrics. The results are interpreted to support a hypothesis which requires a unique combination of structural and environmental features for reaction to occur. Effects of pH, catalyst, and pres ence of moisture on extent of reaction were also studied. Resistance to acid and basic hydrolysis as well as the relative strength retention of treated fabric was determined. Comment is made on the potential utility of the modified fabrics.
A 38 GHz On-Chip Antenna in 28-nm CMOS using Artificial Magnetic Conductor for 5G Wireless Systems (2016)

This paper presents the first-ever millimeter wave on-chip antenna (AoC) in 28 nm CMOS technology. The addition of artificial magnetic conductor (AMC) can increase the antenna's power gain and radiation efficiency to -1.75 dBi and 22%, respectively, with an occupied area of 0.95 mm×4.75 mm at 38 GHz. This structure is intended for fully integrated single-chip nanometer CMOS transceivers for 5G communication systems.
Effects of intravenous fumonisin B1 in rabbits: Nephrotoxicityxs and sphingolipid alterations (1995)

Fumonisin B1 is hepatotoxic in all species, but nephrotoxicity has only been reported in rats. It is a specific inhibitor of sphinganine N-acyltransferase. Our objective was to determine the target organs for fumonisin toxicosis in the rabbit. We administered fumonisin B1 ( > 95% pure) intravenously to adult rabbits and examined selected clinical, biochemical, and histological parameters for up to 5 days. In a pilot study, rabbits were given fumonisin B1 at 1, 0.5, 0.3, 0.15, or 0 mg/kg daily for 4 or 5 days and then euthanized. Additional rabbits were given a single dose of fumonisin B1 at 1 mg/kg and euthanized on day 2 or 4. In the formal time-course study, rabbits were given a single dose of fumonisin B1 at 0 or 1.25 mg/kg and euthanized on days 1, 3, or 5. Rabbits given multiple doses of fumonisin B1 were lethargic and anorectic, and had decreased urine production. Liver- and renal-associated clinical chemistry parameters were elevated. Renal lesions consisted of severe proximal tubular necrosis. Liver lesions were variable and consisted of mild necrosis, hepatocyte vacuolation, and bile stasis. The sphinganine-to-sphingosine ratio, in both target and nontarget tissues, was markedly elevated in treated rabbits. A single dose of fumonisin B1 induced renal but not hepatic injury. Therefore, the target organs for fumonisin B1 toxicity in rabbits are kidney and liver, with the kidney being more sensitive.
Multi-frame motion-compensated video compression for the digital set-top box (2003)

Motion-compensated prediction based on multiple previous or future frames can enhance the compression efficiency of video coding. Multi-frame prediction can be applied as an extension to P-pictures, but also to B-pictures in the form of multi-hypothesis prediction. We review recent advances, several of which have been embraced by the ITU-T Rec. H.263 and the emerging JVT/H.26L standard, jointly developed by ITU-T and ISO/IEC MPEG. Already, JVT/H.26L video outperforms MPEG-2 by a factor greater than 2/spl times/. These recent developments could play a significant role in future digital set-top boxes.
Publish / Subscribe Systems: Design and Principles (2012)

This book offers an unified treatment of the problems solved by publish/subscribe, how to design and implement the solutions In this book, the author provides an insight into the publish/subscribe technology including the design, implementation, and evaluation of new systems based on the technology.&amp;nbsp; The book also addresses the basic design patterns and solutions, and discusses their application in practical application scenarios. Furthermore, the author examines current standards and industry best practices as well as recent research proposals in the area. Finally, necessary content ma
Ten‐year health‐related quality of life in cochlear implant recipients (2013)

This study establishes the long-term sustained benefits of cochlear implantation on quality of life. Nevertheless, both the SF-36 and SF-6D seem to underestimate the benefit accrued through this intervention. Our data are consistent with others regarding the unsuitability of the SF-36 in benefit assessment, notwithstanding that conversion to the SF-6D is feasible, and the SF-6D seemed to better depict possible benefits from cochlear implantation as compared to the SF-36.
Turner syndrome associated with acquired von Willebrand disease, primary biliary cirrhosis, and inflammatory bowel disease (2002)

We report a unique case of Turner syndrome associated with acquired von Willebrand disease (AvWD), primary biliary cirrhosis (PBC), and inflammatory bowel disease (IBD). During 7 years of close follow-up, the patient presented with multiple major episodes of upper and lower gastrointestinal bleeding caused by different pathogenic mechanisms, such as IBD, AvWD, gastric varices, and thrombocytopenia. AvWD mimicking familial vWD type III on laboratory testing was most probably triggered by autoimmune mechanism associated with PBC. Therapy of PBC with ursodeoxycholic acid (UDCA) resulted in significant decrease of liver enzymes followed by normalization of vWF and FVIII levels. Portosystemic shunt placement with ligation of gastric varices improved hypersplenism and severe thrombocytopenia and led to clinical stability for more than 24 months. The clinicopathological features of these disorders and of the recurrent bleeding episodes are discussed in the text along with a review of the literature.
Monitoring the course of enzymatic degradation of pectic substances by automated fast ion chromatography (FIC) (1991)

It was possible to follow the degradation process of the pectic substances, using commercial pectic enzyme preparations. The results show that oligogalacturonic acids with DP=2-6 were degraded to the monomer using Pectinex. The existence of an exo-oligogalacturonase in the commercial pectic enzyme preparation used could therefore be confirmed. During the degradation of Na-polygalacturonate, oligomers with DP=8-9 predominated in the early phase of treatment.
Molecular and Supramolecular Objects from Glycoluril (1999)

\n Contains fulltext :\n 292400.pdf (Publisher’s version ) (Open Access)\n
Relaxation of spins due to field inhomogeneities in gaseous samples at low magnetic fields and low pressures (1988)

We have developed a theory for the effect of magnetic-field inhomogeneities on the spin relaxation of gases in cells with negligible relaxation at the walls. There is a characteristic pressure ${p}^{\mathrm{*}}$ at which the time ${\ensuremath{\tau}}_{d}$ required for an atom to diffuse across the cell is equal to the time ${\ensuremath{\tau}}_{l}$ required for the spin to precess by one radian in the mean magnetic field. For ``high pressures,'' p\ensuremath{\gg}${p}^{\mathrm{*}}$, the longitudinal spin-relaxation time ${T}_{1}$ is inversely proportional to the pressure. This is the classic pressure dependence discussed in the literature. The new results reported in this paper are that at ``low pressures,'' p\ensuremath{\ll}${p}^{\mathrm{*}}$, the pressure dependence changes and the longitudinal relaxation time becomes directly proportional to the pressure; that is, motional narrowing occurs. We show that the transverse relaxation time ${T}_{2}$ will ordinarily be proportional to the pressure at both low and high pressures, but with different coefficients. There is also a small, pressure-dependent shift of the Larmor frequency associated with the field inhomogeneity.
Mass releases ofTrichogrammawasps can reduce damage from codling moth (2000)

Mass releases of commercially produced Trichogramma wasps can be used to reduce damage from codling moth by 60% in walnut and pome fruit orchards in California. Results from field trials indicate that release rate and evenness of distribution are important factors influencing the effectiveness of wasp releases, and that damage reduction is more effective in walnuts and pears than in apples. Because the environmental risks of large-scale releases of Trichogramma wasps are likely to be small, wasp releases could be integrated with pheromone-based mating disruption for effective management of codling moth.
Introduction: TH2-inducing DC2 for immunotherapy (2000)

The concept of tolerogenic dendritic cells (DCs) came from experiments in mice showing that thymic DCs mediated clonal deletion of emerging autoreactive T cells within thymus.[1][1]The finding that lymphoid precursors give rise to both T cells and CD8+CD11b− DCs within the thymus suggests the
Virtual Force Feedback Lessons, Challenges, Future Applications (1993)

Virtual force feedback prototypes have been developed in the last couple of years. Their number of degrees of freedom and range of motion are limited by present (bulky) actuator technology. Lessons from these first prototypes point to possible solutions in the future. Several applications of virtual reality with force feedback are then described.
Purinergic receptor P2Y1 regulates polymodal C-fiber thermal thresholds and sensory neuron phenotypic switching during peripheral inflammation (2011)

We have recently found that, following complete Freund's adjuvant (CFA)-induced inflammation, cutaneous polymodal nociceptors (CPM) lacking the transient receptor potential vanilloid 1 (TRPV1) are sensitized to heat stimuli. In order to determine possible mechanisms playing a role in this change, we examined gene expression in the L2/L3 sensory ganglia following CFA injection into the hairy hind paw skin and found that G-protein-coupled purinoreceptor P2Y1 expression was increased. This receptor is of particular interest, as most CPMs innervating mouse hairy skin bind isolectin B4, which co-localizes with P2Y1. Additionally, our recent findings have shown that cutaneous CPMs in P2Y1-/- mice displayed significantly reduced thermal sensitivity. Together, these findings suggested a possible role for P2Y1 in inflammation-induced heat sensitization in these fibers. To test this hypothesis, we utilized our in vivo small interfering RNA technique to knock down the inflammation-induced increase in P2Y1 expression and then examined the functional effects using ex vivo recording. We found that the normal reduction of heat thresholds in CPM fibers induced by CFA was completely blocked by inhibition of P2Y1. Surprisingly, inhibition of P2Y1 during inflammation also significantly increased the number of CPM neurons expressing TRPV1 without a change in the total number of TRPV1-positive cells in the L2 and L3 dorsal root ganglia. These results show that the inflammation-induced enhanced expression of P2Y1 is required for normal heat sensitization of cutaneous CPM fibers. They also suggest that P2Y1 plays a role in the maintenance of phenotype in cutaneous afferent fibers containing TRPV1.
Comparative survival analysis of multiparametric tests—when molecular tests disagree—A TEAM Pathology study (2021)

Multiparametric assays for risk stratification are widely used in the management of both node negative and node positive hormone receptor positive invasive breast cancer. Recent data from multiple sources suggests that different tests may provide different risk estimates at the individual patient level. The TEAM pathology study consists of 3284 postmenopausal ER+ve breast cancers treated with endocrine therapy Using genes comprising the following multi-parametric tests OncotypeDx<sup>®</sup>, Prosigna™ and MammaPrint<sup>®</sup> signatures were trained to recapitulate true assay results. Patients were then classified into risk groups and survival assessed. Whilst likelihood χ<sup>2</sup> ratios suggested limited value for combining tests, Kaplan-Meier and LogRank tests within risk groups suggested combinations of tests provided statistically significant stratification of potential clinical value. Paradoxically whilst Prosigna-trained results stratified Oncotype-trained subgroups across low and intermediate risk categories, only intermediate risk Prosigna-trained cases were further stratified by Oncotype-trained results. Both Oncotype-trained and Prosigna-trained results further stratified MammaPrint-trained low risk cases, and MammaPrint-trained results also stratified Oncotype-trained low and intermediate risk groups but not Prosigna-trained results. Comparisons between existing multiparametric tests are challenging, and evidence on discordance between tests in risk stratification presents further dilemmas. Detailed analysis of the TEAM pathology study suggests a complex inter-relationship between test results in the same patient cohorts which requires careful evaluation regarding test utility. Further prognostic improvement appears both desirable and achievable.
A Review of the Evolution of Termite Control: A Continuum of Alternatives to Termiticides in the United States with Emphasis on Efficacy Testing Requirements for Product Registration (2022)

The global economic impact of termites is estimated to be approximately USD 40 billion annually, and subterranean termites are responsible for about 80% of the total impact. Twenty-eight species of termites have been described as invasive, and these termites are spreading, partially due to global trade, making effective control methods essential. Termite control is complex, as is the biology and behavior of this social insect group. In the U.S., termite prevention and control (with claims of structural protection) is regulated by more than one industry (pest control and building construction), and at the federal and state levels. Termite prevention has historically relied on building construction practices that do not create conducive conditions for termite infestations, but as soil termiticides developed, heavy reliance on pesticides became the standard for termite control. The concern for human and environmental health has driven the development of termite control alternatives and regulation for products claiming structural protection. Product development has also provided unprecedented opportunities to study the biology and behavior of cryptobiotic termites. Technological advances have allowed for the re-examination of questions about termite behavior. Advances in communications via social media provide unrestricted access to information, creating a conundrum for consumers and science educators alike.
Purification and Characterization of α-Galactosidase from Watermelon (1986)

An alpha-galactosidase [EC 3.2.1.22] was isolated from the fruit of the watermelon, Citrullus battich. The enzyme was purified by procedures including extraction, ammonium sulfate precipitation, and chromatographies on DEAE-Sephadex, CM-Sephadex and Sephadex G-100. The final preparation was found to be fairly homogeneous on disc and SDS-polyacrylamide gel electrophoresis, and sufficiently free from other glycosidase activities. The molecular weight of the enzyme was estimated to be 45,000 by Sephadex G-100 column chromatography and SDS-polyacrylamide gel electrophoresis. The enzyme was most active at pH 4.5 for natural substrates and at 5.9 for artificial substrates. The enzyme liberates the alpha-galactose units from oligosaccharides of the raffinose series and ceramide trihexoside, and the hemagglutination-inhibiting activities of human ovarian cyst B-glycoprotein and blood group B-type ghosts were abolished by the enzyme.