gebhart/patrepeval huggingface dataset:
ChemInform Abstract: The Application of L‐Proline as an Enzyme Mimic and Further New Asymmetric Syntheses Using Small Organic Molecules as Chiral Catalysts. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Achiral Molecules Move and Order Themselves in a Chiral Form in Host-Guest Inclusion Crystals (1995)

Abstract When optically active host compound was mixed with achiral guest compound in the solid state, host-guest inclusion crystals were formed by molecular movement and the achiral molecules became arranged in a chiral form in the inclusion crystals. Mixing of powdered (+)-host crystals with powdered (−)-guest crystals which are formed by a chiral arrangement of achiral guest molecules gave inclusion crystals of the (+)-host and the (+)-guest molecules newly produced through an inversion of the (−)-guest molecules during the complexation in the solid state.
Cell Transplantation from Limb Allografts (1998)

A murine model of skeletal tissue transplantation was developed to study the allograft rejection process in mice for limb allograft transplantation. Muscle, bone, and skin have been shown to be strong antigenic stimuli in vascularized allograft models, and cells from these sources were used for transplantation. Using enzymatic digestion, keratinocytes, myocytes, and osteocytes were harvested from B10.A mice tissues, dissociated into single cells, and then grown in culture for 14 to 21 days. Each cell type was marked with an intracellular fluorescent marker before transplantation of the cells into pockets in the rectus abdominis muscle of a syngenic host. All cell types remained viable and were detectable 2 weeks following transplantation when examined histologically and observed under a fluorescent microscope. Transplanted osteocytes were found to produce bone 8 weeks following transplantation. These results demonstrate that individual cells transplanted into muscle pockets survive and have the ability to produce extracellular matrix in this mouse model of skeletal tissue transplantation. Use of this model will allow transplantation of the cellular components comprising limb allografts to study the relative antigenicities and the rejection of the separate cells with the advanced immunologic techniques available for mice. A better understanding of immunologic responses to these individual tissue components may enable specific donor tissue or host immune modification to achieve skeletal tissue transplantation without immunosuppression. These findings are particularly valuable to the field of tissue engineering where allogeneic cells may be used in cell/polymer constructs for reconstructive procedures.
[Isolation of coronaviruses in cell culture from nasal swab samples of calves with respiratory tract diseases in the Federal Republic of Germany]. (1989)

Coronavirus was isolated in HRT-18 tissue culture from nasal swabs of 4 from 15 calves showing respiratory symptoms. The strains showed cytopathic effects and could be identified as coronaviruses of bovine origin by their mouse erythrocyte agglutinating activity as well as serological specific hemagglutination inhibition and electron microscopical methods. This is the first report on the isolation of coronaviruses in tissue culture from the respiratory tract of calves in the FRG.
Study on asymmetry of applied electric field in micro EHD pump (2018)

In recent years, miniaturization of mechanical elements is interesting with improving machine function. If mechanical elements are miniaturized as the simple method, it is expected that physical and mechanical limitations exist. Therefore, researchers have been studying effective actuators and sensors in a minute space. Recent study of micro-actuators without mechanical elements is getting much attention especially on “chemical actuators” without mechanical elements. For the present study we focused on Electro-Hydro-Dynamic: EHD as chemical actuators. The functions of EHD are driven when the high electric field is applied to dielectric fluid. The development of micro-EHD pump was carried out which has a simple structure and easy to manufacture. This micro-EHD pump has little loss in terms of both of fluid effect and electro-chemical effect.
An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity (2008)

Type I IFNs were discovered as the primary antiviral cytokines and are now known to serve critical functions in host defense against bacterial pathogens. Accordingly, established mediators of IFN antiviral activity may mediate previously unrecognized antibacterial functions. RNase-L is the terminal component of an RNA decay pathway that is an important mediator of IFN-induced antiviral activity. Here, we identify a role for RNase-L in the host antibacterial response. RNase-L(-/-) mice exhibited a dramatic increase in mortality after challenge with Bacillus anthracis and Escherichia coli; this increased susceptibility was due to a compromised immune response resulting in increased bacterial load. Investigation of the mechanisms of RNase-L antibacterial activity indicated that RNase-L is required for the optimal induction of proinflammatory cytokines that play essential roles in host defense from bacterial pathogens. RNase-L also regulated the expression of the endolysosomal protease, cathepsin-E, and endosome-associated activities, that function to eliminate internalized bacteria and may contribute to RNase-L antimicrobial action. Our results reveal a unique role for RNase-L in the antibacterial response that is mediated through multiple mechanisms. As a regulator of fundamental components of the innate immune response, RNase-L represents a viable therapeutic target to augment host defense against diverse microbial pathogens.
A 16x16-pixel pulse-frequency-modulation based image sensor for retinal prosthesis (2006)

We have designed and fabricated a 16/spl times/16-pixel retinal prosthesis device using a pulse-frequency-modulation (PFM) photosensor. This chip is a prototype for demonstrating applications in in-vitro electrophysiological experiments. Each pixel has a bonding pad on which a stimulus electrode is formed by a Pt/Au stacked biocompatible bump electrode. We have evaluated the PFM retinal implant chip by in-vitro electrophysiological experiments using detached frog retina, and confirmed that it can electrically stimulate the retinal cells effectively.
THE IN VITRO FORMATION OF ACETYL‐ASPARTYL‐PEPTIDO‐SEROTONIN COMPLEXES BY PIG HYPOTHALAMIC TISSUE EXTRACTS (1978)

Abstract— Peptido‐serotonin complexes are formed on incubation of pig hypothalamic tissue extracts with acetyl‐aspartate, the amino acids glu. ser, gly and ala. an ATP‐regenerating system and serotonin. The purification and partial characterisation of two acetyl‐aspartyl‐peptido‐serotonin complexes is described.
A differential scanning calorimetric study of the thermal unfolding of mutant forms of phage T4 lysozyme (1992)

In continuation of our earlier work on the effects of amino acid replacements on the thermodynamics of the thermal unfolding of T4 lysozyme [Kitamura, S., & Sturtevant, J. M. (1989) Biochemistry 28, 3788-3792; Connelly, P., Ghosaini, L., Hu, C.-Q., Kitamura, S., Tanaka, A., & Sturtevant, J. M. (1991) Biochemistry 30, 1887-1891; Hu, C.-Q., Kitamura, S., Tanaka, A., & Sturtevant, J. M. (1992) Biochemistry 31, 1643-1647], we report here a study by differential scanning calorimetry of the effects of five replacements at Ile3. Four of these replacements, those with Glu, Phe, Pro, and Thr, caused apparent destabilizations, while the replacement by Leu led to a small apparent stabilization. The largest observed destabilization (Ile3Pro) amounted to -3.0 kcal mol-1 in free energy at pH 2.00 and 38.8 degrees C (the denaturational temperature of the wild-type protein at this pH), and the largest stabilization amounted to +1.2 kcal mol-1 at pH 3.00 and 53.6 degrees C.
Luminescence quenching in epitaxially grown PCN-224 type metal–organic frameworks (2022)

Probing core–shell and multivariant MOFs of the PCN-224 type prepared from metal-free and metalated porphyrin building blocks with luminescence quenching upon exposure to oxygen reveals oxygen quenching to occur also in the core of the MOF.
Magnetic frustration in the high-pressure Mn2MnTeO6 (Mn3TeO6-II) double perovskite (2019)

A new double perovskite Mn2MnTeO6 has been obtained by high pressure phase transformation of a corundum-related precursor. It is antiferromagnetic below 36 K and develops a magnetic structure with magnetic moments of 4.8 μB and 3.8 μB for Mn2+ at the A and B sites respectively. This new polymorph accounts for a recently reported decrease in the bandgap of Mn3TeO6 under pressure that may lead to useful light-harvesting properties.
Cortical Projection of Peripheral Vestibular Signaling (2003)

The cerebral projection of vestibular signaling was studied by using PET with a special differential experimental protocol. Caloric vestibular stimulation (CVS)-induced regional cerebral blood flow (rCBF) changes were investigated in two populations. Butanol perfusion scans were carried out on six healthy volunteers and on six patients following the removal of tumors from the right cerebello pontine angle. The complete loss of the vestibular function postoperatively allowed a comparison of the rCBF changes in the populations with or without this input and offered a promising functional approach whereby to delineate the cortical region most responsive to pure vestibular input. The activations by left-sided and right-sided CVS were determined for both the healthy volunteers and the patient population. Statistical analysis of the data obtained following left-sided CVS did not reveal any cerebral region for which there was a significant difference in CVS-induced response by these two populations. In the case of right-sided CVS, however, the statistical comparison of the CVS-related responses demonstrated a single contralateral area characterized by a significantly different degree of response. This cortical area corresponds to part of the cortical region described recently which can be activated by both CVS and neck vibration. It appears to be anatomically identical to the aggregate of the somatosensory area SII and the retroinsular cortex described in primates, a region identified by other investigators as an analog of the parietoinsular vestibular cortex.
Cyclic adenosine 3',5'-monophosphate regulation of the bacteriophage T6/colicin K receptor in Escherichia coli (1979)

Mutant strains of Escherichia coli unable to synthesize cyclic adenosine 3',5'-monophosphate (cAMP) or the cyclic adenosine monophosphate receptor protein (CRP) were more resistant than wild-type cells to infection by bacteriophage T6. This resistance was found to be associated with the decreased production of specific T6 receptor protein (also the colicin K receptor) located in the outer membrane protein fraction of these cells. Transcription of this particular outer membrane protein was regulated by the cAMP-CRP complex. A novel affinity technique coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis was used in these investigations.
Multichannel CSMA/CA Protocol for OFDMA-Based Broadband Power-Line Communications (2013)

Channel response and noise in the in-home power-line channel are time varying, and show periodic patterns since electric devices, which are major noise sources, synchronously run with the ac-line cycle. Using the relatively stable channel characteristic of the power line, orthogonal frequency-division multiple access (OFDMA) schemes in power-line communications (PLCs) can achieve multiuser diversity gain even in random access. In this paper, we propose a carrier-sense multiple access with a collision-avoidance (CSMA/CA) protocol for OFDMA-based broadband PLC. To achieve the maximum diversity gain, we formulate a utility maximization problem for our considered framework. Then, we solve this problem by dividing it into two subproblems. The first one divides the whole bandwidth into a certain number of subchannels appropriately, and then the second one allocates a subchannel to each node according to the channel condition. To solve each subproblem, we first consider optimal algorithms and then heuristic algorithms to overcome the complexity. Through extensive simulations, we show that our proposal greatly improves the overall system utility compared to the single-channel CSMA/CA scheme. The performance improvement of our proposal over the single channel scheme is mainly achieved by lowering collision probability and exploiting multiuser diversity.
Pharmacological activity and chemical composition of callus culture extracts from selected species of Phyllanthus. (2000)

This study was conducted in order to determine the chemical composition and the possible antinociceptive effects in mice of some species of Phyllanthus in vitro. The methanolic extracts obtained from callus cultures of P. fraternus, P. stipulatus and P. caroliniensis caused significant inhibition in to the late phase of the formalin test, whereas the extract from P. urinaria inhibited both neurogenic and inflammatory phases of the test. Conventional chromatographic methods (TLC, GC) permitted the detection of some steroids or triterpenes, including beta-sitosterol, glochidonol and glochidone, which seem be responsible for the antinociceptive effects of the callus extracts studied.
Frontispiece: Mechanical Trap Surface‐Enhanced Raman Spectroscopy for Three‐Dimensional Surface Molecular Imaging of Single Live Cells (2017)

Single Cell Imaging I. Barman, D. H. Gracias et al. present in their Communication on page 3822 ff. a micromechanical SERS sensor for the simultaneous capture and visualization of the chemical composition of a single cellular surface.
Implementation of a low-complexity low-latency arbitrary resampler on GPUs (2014)

Modern communication systems have data rates and sampling rates that are tightly coupled. Resampling is necessary in order to convert to some desired sampling rate, which is usually a multiple of the data rate. The resampling process is an integral part of transceiver systems and must be designed accurately and carefully. In this paper, we present a low complexity and low latency arbitrary resampling method based on graphics processing units (GPUs). Our proposed flexible and all-software-based resampling method requires no precomputation of filters and yet yields high performance by taking advantage of unique features found in GPUs.
Cyclic Dimeric GMP Signaling Regulates Intracellular Aggregation, Sessility, and Growth of Ehrlichia chaffeensis (2011)

Cyclic dimeric GMP (c-di-GMP), a bacterial second messenger, is known to regulate bacterial biofilm and sessility. Replication of an obligatory intracellular pathogen, Ehrlichia chaffeensis, is characterized by formation of bacterial aggregates called morulae inside membrane-bound inclusions. When E. chaffeensis matures into an infectious form, morulae become loose to allow bacteria to exit from host cells to infect adjacent cells. E. chaffeensis expresses a sensor kinase, PleC, and a cognate response regulator, PleD, which can produce c-di-GMP. A hydrophobic c-di-GMP antagonist, 2'-O-di(tert-butyldimethysilyl)-c-di-GMP (CDGA) inhibits E. chaffeensis internalization into host cells by facilitating degradation of some bacterial surface proteins via endogenous serine proteases. In the present study, we found that PleC and PleD were upregulated synchronously during exponential growth of bacteria, concomitant with increased morula size. While CDGA did not affect host cells, when infected cells were treated with CDGA, bacterial proliferation was inhibited, morulae became less compact, and the intracellular movement of bacteria was enhanced. Concurrently, CDGA treatment facilitated the extracellular release of bacteria with lower infectivity than those spontaneously released from sham-treated cells. Addition of CDGA to isolated inclusions induced dispersion of the morulae, degradation of an inclusion matrix protein TRP120, and bacterial intrainclusion movement, all of which were blocked by a serine protease inhibitor. These results suggest that c-di-GMP signaling regulates aggregation and sessility of E. chaffeensis within the inclusion through stabilization of matrix proteins by preventing the serine protease activity, which is associated with bacterial intracellular proliferation and maturation.
Performance Impact of Processor and Memory Heterogeneity in a Network of Machines (1995)

In this paper we present a summary of the issues that need to be dealt with to effectively use a heterogeneous network of machines. We specifically point out the impact of processor and memory heterogeneity on the performance of parallel programs. Our results indicate that processor speeds are application dependent and we show how to use this information along with memory constraints for efficient scheduling. 1 Introduction Network based distributed computing has attracted a lot of attention lately, due to the recent advances in high speed networks having low latency and high bandwidth, and due to the ubiquitous presence of workstations linked over LANs. With most of the machines in a network underutilized, there has been research on harnessing this power in a useful way, for example, to use the workstations to solve the so called &amp;quot;grand challenge&amp;quot; problems. A network of machines (NOM) can have heterogeneity at various levels [3]. More specifically, the NOM may be heterogeneous in the...
Transition shape effect in the transients generated by a Programmable Josephson Voltage Standard (2010)

This study addresses the effect of the transients on the operation of a 1 V programmable Josephson voltage standard. A careful modeling of the bias current dependence of the waveform generated shows that the particular shape of the voltage transition has little influence on the harmonic contents of the waveform. The critical point is the timing associated with the transition.
A Cycle-Accurate ISS for a Dynamically Reconfigurable Processor Architecture (2005)

Reconfigurable processor architectures (RAs) have been proving as an effective way to couple significant performance improvements with severe energy constraints, such as those imposed by modern portable real-time applications. XiRisc is a VLIW RISC processor architecture featuring a reconfigurable dataflow-oriented functional unit, the so-called PiCoGA, allowing run-time dynamic extension of the instruction set. In this paper, we propose a LISA-based instruction set simulator (ISS) for the reconfigurable processor, retargetable through a dynamically linked library that emulates instruction set extension. The ISS comprises a SystemC system-level model with embedded bus architecture and memory hierarchy (on-chip and off-chip) to provide a reconfigurable system-on-chip performance evaluator.
Large‐Deformation, Multifunctional Artificial Muscles Based on Single‐Walled Carbon Nanotube Yarns (2014)

Helical shape, wax-infiltrated SWNT yarns are fabricated into multifunctional electromechanical actuators to produce large tensile contraction and unique functions including dragging an object, changing shape, self-twisting, and tightening an object, all of which can be generated in simple configurations under small voltages.
Mixture Analysis in Combinatorial Chemistry. Application of Diffusion-Resolved NMR Spectroscopy (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTMixture Analysis in Combinatorial Chemistry. Application of Diffusion-Resolved NMR SpectroscopyMengfen Lin and Michael J. ShapiroView Author Information Preclinical Research, Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, 59 Route 10, East Hanover, New Jersey 07936 Cite this: J. Org. Chem. 1996, 61, 21, 7617–7619Publication Date (Web):October 18, 1996Publication History Received10 July 1996Published online18 October 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo961315thttps://doi.org/10.1021/jo961315tbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views641Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Diffusion,Mixtures,Organic compounds,Quantum mechanics,Transport properties Get e-Alerts
Bilinear Input Normalization for Neural Networks in Financial Forecasting (2021)

Data normalization is one of the most important preprocessing steps when building a machine learning model, especially when the model of interest is a deep neural network. This is because deep neural network optimized with stochastic gradient descent is sensitive to the input variable range and prone to numerical issues. Different than other types of signals, financial time-series often exhibit unique characteristics such as high volatility, non-stationarity and multi-modality that make them challenging to work with, often requiring expert domain knowledge for devising a suitable processing pipeline. In this paper, we propose a novel data-driven normalization method for deep neural networks that handle high-frequency financial time-series. The proposed normalization scheme, which takes into account the bimodal characteristic of financial multivariate time-series, requires no expert knowledge to preprocess a financial time-series since this step is formulated as part of the end-to-end optimization process. Our experiments, conducted with state-of-the-arts neural networks and high-frequency data from two large-scale limit order books coming from the Nordic and US markets, show significant improvements over other normalization techniques in forecasting future stock price dynamics.
Design and testing of Ultralite Fabric Reflux Tubes (1993)

This paper describes the design, fabrication, and testing of Ultralite Tubes intended to provide thermal management for habitat modules in a lunar colony. The Ultralite Fabric Reflux Tubes, under this phase of development, are constructed of thin‐walled copper liners overwrapped with aluminoborosilicate fabric. These devices were constructed and tested in air at the Pacific Northwest Laboratory and subsequently taken to the NASA Johnson Space Center for thermal vacuum experimentation.