gebhart/patrepeval huggingface dataset:
Laser Treatment of Eye Disorders in Children (1991)

The increasing range of indications for laser treatment and the development of new modalities of lasering have led to a growing tendency to extend this type of treatment to the pediatric population. Problems of compliance in this age group often necessitate the use of general anesthesia. This report describes the operative technique used in 11 children (13 eyes) under the age of 13 years, all of whom underwent laser treatment under general anesthesia for a variety of ocular conditions. Argon or krypton laser photocoagulation was performed in eight children (10 eyes), seven of whom were treated for various retinal pathologies and one for an iris cyst. The other three children underwent Nd:YAG posterior capsulotomy for secondary cataract.
Epigenetic and transcriptional mechanisms for the regulation of IL-10 (2019)

IL-10 is a critical immunoregulatory cytokine expressed in virtually all immune cell types. Maintaining a delicate balance between effective immune response and tolerance requires meticulous and dynamic control of IL-10 expression both epigenetically and transcriptionally. In this Review, we describe the epigenetic mechanisms controlling IL-10 expression, including chromatin remodeling, 3D chromatin loops, histone modification and DNA methylation. We discuss the role of transcription factors in directing chromatin modifications, with a special highlight on the emerging concept of pioneer transcription factors in setting up the chromatin landscape in T helper cells for IL-10 induction. Besides summarizing the recent progress on transcriptional regulation in specialized IL-10 producers such as type 1 regulatory T cells, regulatory B cells and regulatory innate lymphoid cells, we also discuss common transcriptional mechanisms for IL-10 regulation that are shared with other IL-10 producing cells.
Ion beam processing of advanced electronic materials (1989)

This report contains research programs discussed at the materials research society symposia on ion beam processing of advanced electronic materials. Major topics include: shallow implantation and solid-phase epitaxy; damage effects; focused ion beams; MeV implantation; high-dose implantation; implantation in III-V materials and multilayers; and implantation in electronic materials. Individual projects are processed separately for the data bases. (CBS)
REEVALUATION OF THE 1997 TNM CLASSIFICATION FOR RENAL CELL CARCINOMA: T1 AND T2 CUTOFF POINT AT 4.5 RATHER THAN 7 CM. BETTER CORRELATES WITH CLINICAL OUTCOME (2001)

Our data imply that the current cutoff point of 7 cm. between stages T1 and T2 tumors is too high. Lowering the cutoff to 4.5 cm. resulted in better discriminatory power of the TNM classification in our dataset. This observation should be further validated by external data.
Expression of Sialosyl-T and Disialosyl-T Antigens in Erythroid Cells (1997)

Expression of T, sialosyl-T and disialosyl-T antigens on normal blood and bone marrow cells as well as transformed cells was examined using specific monoclonal antibodies and multidimensional flow cytometry. Both anti-sialosyl-T (QSH1) and anti-disialosyl-T (QSH2) monoclonal antibodies aggregated erythrocytes. The anti-disialosyl-T antibody was specific for the erythroid lineage and did not react with neutrophils, monocytes or T-lymphocytes, while the anti-sialosyl-T antibody reacted with erythroid cells and a subset of T-lymphocytes. The developing erythroid cells in bone marrow showed coordinate expression of glycophorin A and the two carbohydrate chains, sialosyl-T and disialosyl-T. Analysis of neoplastic cells showed that the anti-disialosyl-T antibody only reacted with glycophorin A-positive blasts from erythroleukemia (FAB M6) patients (4/4) and one patient with chronic myeloid leukemia in erythroblastic transformation (CMLET). Leukemic blasts from these patients demonstrated coordinate quantitative expression of glycophorin A and disialosyl-T. The anti-sialosyl-T antibody reacted with glycophorin A-positive blasts from FAB M6 patients (4/4) and one CMLET patient; however, the antibody also reacted with glycophorin A-negative blasts from one FAB M6 and the one CMLET patients and transformed cells from other types of leukemia. The anti-T monoclonal antibody (HH8) did not react with any of the other cells tested. These results indicate that glycophorin A and disialosyl-T expression are tightly linked during normal erythroid development and erythroid leukemogenesis.
In Memoriam (2004)

Benjamin L. Van Duuren, a world-class expert in the field of cancer causation and prevention using chemical and analytical techniques, died November 13, 2003. He was 77 years old.

Dr. Van Duuren earned an Sc.D. (Doctor of Natural Sciences) in organic chemistry in 1951 from the University of South
PREDICTORS OF OUTCOME IN TRAUMA DURING PREGNANCY-IDENTIFICATION OF PATIENTS WHO CAN BE MONITORED FOR LESS THAN SIX HOURS (1999)

s Of Papers To Be Presented At The Fifty-Ninth Annual Meeting Of The American Association For The Surgery Of Trauma; Marriott Copley Place Hotel, Boston, Massachusetts; September 16-18, 1999
Leaching of Nitrate from Freely Drained–Irrigated Fields Treated with Municipal Sludges (1988)

A municipal sludge land application experiment was initiated in 1975 near Riverside, California. From 1975 to 1983 sludges from the Los Angeles Metropolitan Area were applied on experimental plots where crops were grown annually. Results indicated that (1) crop yields were not affected by the sludge application and the total biomass harvested was a function of total N input, (2) the extent and the rate of N mineralization of liquid sludges were consistently higher than composted sludges and the sludge application rate and the soil type did not affect mineralization of N, and (3) nitrogen application exceeding N requirements for crop growth always results in leaching and accumulation of nitrate in the soil profile.
c‐Jun is essential for the induction of Il‐1β gene expression in in vitro activated Bergmann glial cells (2011)

In the central nervous system (CNS), the c-Jun transcription factor has been mainly studied in neuronal cells and coupled to apoptotic and regenerative pathways following brain injury. Besides, several studies have shown a transcriptional role of c-Jun in activated cortical and spinal astrocytes. In contrast, little is known about c-Jun expression and transactivation in Bergmann glial (BG) cells, the radial cerebellar astrocytes playing crucial roles in cerebellar development and physiology. Here, we used neuronal/glial cerebellar cultures from neonatal mice to assess putative functions of c-Jun in BG cells. By performing double immunocytochemical staining of c-Jun and two BG specific markers, S100 and glutamate aspartate transporter (GLAST), we show that c-Jun was highly expressed in radial glial cells derived from Bergmann glia. Bergmann glia-derived cells expressed toll-like receptor 4 and treatment with bacterial lipopolysaccharide (LPS)-induced c-Jun phosphorylation at serine 63, a hallmark of c-Jun transactivation, exclusively in BG cells. Moreover, LPS-induced IL-1β expression and inhibition of c-Jun N-terminal kinase (JNK) activity abolished both c-Jun phosphorylation and the increase of IL-1β mRNA. Notably, LPS failed to induce IL-1β mRNA in neuronal/glial cerebellar cultures generated from conditional knockout mice lacking c-Jun expression in the CNS, indicating the essential role of c-Jun in astroglial-specific induction of IL-1β. Immunohistochemical analyses of c-Jun-expressing cells in the early postnatal cerebellum confirmed in vivo the expression of c-Jun in BG cells and uncovered a dynamic expression of c-Jun during the formation of the BG monolayer. Altogether, our finding underlines a putative role of c-Jun in astroglia-mediated neuroinflammatory dysfunctions of the cerebellum.
Collector optimization in advanced SiGe HBT technologies (2005)

With the advancement of the fT/fMAX performance scaling of SiGe HBTs the breakdown voltage (BVCBO/BVCEO) reduces commensurately, causing design related concerns. It is important, therefore, that multiple fT/BVCEO devices be offered in the RF technologies to meet the varying needs of the communication products. Unlike the GaAs technologies, the SiGe BiCMOS technologies are capable of integrating various flavors of fT/BVCEO SiGe HBT devices at a technology node. In this work, we investigate the tradeoff in fT-BVCEO for advanced SiGe HBTs by various collector optimization schemes such as, subcollector dopant species and concentration, epilayer thickness, SIC and other layout techniques.
Micro-Welding of Copper Plate by Frequency Doubled Diode Pumped Pulsed Nd:YAG Laser (2012)

A pulsed laser of 532 nm wavelength with ms range pulse duration was newly developed by second harmonic generation of diode pumped pulsed Nd:YAG laser. High electro-optical conversion efficiency more than 13% could be achieved, and 1.5 kW peak power green laser pulse was put in optical fiber of 100 μm in diameter. In micro- welding of 1.0 mm thickness copper plate, a keyhole welding was successfully performed by 1.0 kW peak power at spot diameter less than 200 μm. The frequency doubled pulsed laser improved the processing efficiency of copper welding, and narrow and deep weld bead was stably obtained.
Window-Based Statistical Analysis Of Timing Subcomponents For Efficient Detection Of Malware In Life-Critical Systems (2019)

Securing life-critical embedded systems, particularly medical devices, requires both proactive security measures that prevent intrusions and reactive measures that detect intrusions. This paper presents a novel model for specifying the normal timing for operations in software applications using cumulative distribution functions of timing subcomponent within sliding execution windows. We present a probabilistic formulation for estimating the presence of malware for individual operations by monitoring the internal timing of the different components of the system, and we define thresholds to minimize false positives based on training data. Experimental results with a smart connected pacemaker and three sophisticated mimicry malware scenarios demonstrate improved performance and accuracy compared to state-of-the-art timing-based malware detection.
Control of Molecular Orientation in Electrostatically Stabilized Ferroelectric Liquid Crystals (2003)

The continuously reorientable (XY-like) ferroelectric polarization density of a chiral smectic liquid crystal is shown experimentally to produce nearly complete screening of the applied electric field in an appropriate cell geometry. This screening, combined with the expulsion of polarization charge for large polarization materials, is shown to produce electrostatic control of the orientation of a uniform optic axis or polarization field.
Influence of the Coanda effect on color Doppler jet area and color encoding. In vitro studies using color Doppler flow mapping. (1992)

We studied surface adherence and its effects on color Doppler jet areas and color encoding in an in vitro model with a noncompliant receiving chamber into which a steady flow jet was directed parallel to either a straight or a curved surface adjacent to and 4 mm away from the inflow orifice (1.50 mm2) with the control condition being a free jet matched for flow rates and driving pressures. Jets were imaged perpendicular to the plane of the surface, the plane in which most clinical images of jet-surface interactions are obtained. Ten different flow rates ranging from 0.13 to 0.30 l/min were used. Surface-adherent jet areas were smaller than control jets for every driving pressure-volume combination (paired t test, p less than 0.01). Computer analysis of color Doppler images showed more green and blue (reverse flow) pixels on the surface side of the adherent jets than the control jets (p less than 0.05), suggesting that viscous energy loss and flow deceleration and reversal play a role in the jet-surface interaction. Analysis of variance demonstrated that linear regression slopes of flow rate versus jet area for surface jets were lower (slopes, 11-21 cm2/l/min; r = 0.95-0.97) than those for the control (slope, 33 cm2/l/min; r = 0.97) (p less than 0.0001). Surface adherence (Coanda effect) influences jet size and color encoding, causing smaller color Doppler jet areas and greater variance and reverse velocity encoding.
ChemInform Abstract: Structure of Mescengricin, a Novel Neuronal Cell Protecting Substance Produced by Streptomyces griseoflavus. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Intestinal microbiota composition after antibiotic treatment in early life: the INCA study (2015)

ClinicalTrials.gov NCT02536560. Registered 28 August 2015.
Identification of the novel tigecycline resistance gene tet(X6) and its variants in Myroides, Acinetobacter and Proteus of food animal origin (2020)

This study identified a novel type of tigecycline resistance gene, tet(X6), in Myroides, Acinetobacter and Proteus from chickens and swine. Tet(X6) conferred lower tetracycline/glycylcycline MICs than other Tet(X) variants, and ISCR2 may play a role in the transmission of tet(X6).
Interdiffusion in (A,B)O‐type Solid Solutions and the Validity of Darken′s Equation (1974)

Abstract Relations between tracer diffusion coefficients and interdiffusion coefficients for quasibinary oxide solid solutions are derived. It is demonstrated that under certain conditions Darken‐type equations are obtained. By inserting experimentally determined interdiffusion coefficients and tracer diffusion coefficients in the Darken relation for (Co,Mg)O and (Co,Ni)O at 1300°C in air it is shown that the Darken‐type equation cannot be employed for interdiffusion in these systems. This is attributed to deviations from local point defect equilibrium in the diffusion couple, which is contrary to a major assumption in the derivation. Experimentally determined interdiffusion coefficients and tracer diffusion coefficients for Co‐cations are reported for various compositions in (Co,Mg)O at 1300°C in air.
Improved OPO brightness with a GRM non-confocal unstable resonator (1996)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. Chandra, T. H. Allik, J. A. Hutchinson, and M. S. Bowers, "Improved OPO brightness with a GRM non-confocal unstable resonator," in Advanced Solid State Lasers, S. Payne and C. Pollack, eds., Vol. 1 of OSA Trends in Optics and Photonics Series (Optica Publishing Group, 1996), paper OP11. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Supplementary Figure 3 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit (2023)

&lt;p&gt;Gb3-expression is down-regulated in senescent cancer cells (marked by SA-β-galactosidase)&lt;/p&gt;
Study on the Usefulness of Shampoo Containing 0.75% Miconazole Nitrate for Treatment of Dandruff-A Double-Blind, Comparative Study. (1997)

フケ症を対象に,0.75%硝酸ミコナゾールシャンプー(MZS)の有用性を,シャンプー基剤(BSS)を対照として8施設による二重盲検比較試験により検討を行った.また,フケおよびかゆみに対する症状の改善とMalassezia furfurの菌数の減少,すなわち真菌学的効果との関係についても併せて検討した.その結果,総症例数134例中,安全性解析対象症例は130例,有効性および有用性解析対象症例は108例であった.有用率はMZS群58例中34例(58.6%),BSS群50例中19例(38.0%)であり,MZS群がBSS群に比し有意に優れる成績であった(p=0.020).フケの改善率では,MZS群58例中42例(72.4%),BSS群50例中26例(52.0%)であり,MZS群がBSS群に比し有意に優れる成績であった(p=0.017).M.furfurに対する真菌学的効果とフケに対する有効性に関して,効果の発現がみられた症例においては,菌数の有意な減少が認められた(p=0.0001).これに対し,無効の症例では試験開始前と終了後の菌数の変化に有意差を認めなかった.また,試験開始時の菌数による有効性の層別解析では,菌数が比較的多い症例において,MZS群がBSS群に比し有意に優れていた(p=0.038).副作用は130例全例において全く認められなかった.以上より,MZSはフケ症に対して有効であり,フケの改善とM.furfur菌数の減少とも比較的一致する極めて有用なシャンプー剤であると考えられた.
New Media in Pediatric Surgery: Innovations That Have Changed the Way We Educate and Communicate (2014)

Within the past decade, surgical instrumentation, technology, and techniques have radically advanced to provide our patients with better surgical options. Most of this has focused on the introduction of minimally invasive techniques. However, but many do not realize is that the same time the technologies surrounding the surgical practice was also advancing. New innovations have improved communication and education amongst surgeons as well as between surgeons and their patients. This special edition of European Journal of Pediatric Surgery will review "New Media" and some of the newest and most influential technology relating to the education and communication in pediatric surgery. Following is a list of what may be the greatest technological advancements in communication and education in pediatric surgery within the past decade.
Regulation of γδ Versus αß T Lymphocyte Differentiation by the Transcription Factor SOX13 (2007)

alphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a gammadelta-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes gammadelta T cell development while opposing alphabeta T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of gammadelta T cells but not alphabeta T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.
Activity of Nadifloxacin against Methicillin-Resistant Staphylococcus aureus Isolated from Skin Infections: Comparative Study with Seven other Fluoroquinolones (1996)

The in vitro susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) to nadifloxacin and seven other fluoroquinolones (norfloxacin, ofloxacin, enoxacin, ciprofloxacin, lomefloxacin, tosufloxacin and sparfloxacin) was evaluated. The MRSA isolates were isolated from 114 skin infections between 1991 and 1994. Nadifloxacin exhibited the lowest minimum inhibitory concentration and there were no MRSA isolates resistant to nadifloxacin, while there were some resistant to all of the other seven fluoroquinolones. The minimum concentrations of these drugs needed to cause 50% inhibition of the isolates increased dramatically from 1991 to 1992, but has hardly changed since 1992.
Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure (2017)

Recoding viral genomes by numerous synonymous but suboptimal substitutions provides live attenuated vaccine candidates. These vaccine candidates should have a low risk of deattenuation because of the many changes involved. However, their genetic stability under selective pressure is largely unknown. We evaluated phenotypic reversion of deoptimized human respiratory syncytial virus (RSV) vaccine candidates in the context of strong selective pressure. Codon pair deoptimized (CPD) versions of RSV were attenuated and temperature-sensitive. During serial passage at progressively increasing temperature, a CPD RSV containing 2,692 synonymous mutations in 9 of 11 ORFs did not lose temperature sensitivity, remained genetically stable, and was restricted at temperatures of 34 °C/35 °C and above. However, a CPD RSV containing 1,378 synonymous mutations solely in the polymerase L ORF quickly lost substantial attenuation. Comprehensive sequence analysis of virus populations identified many different potentially deattenuating mutations in the L ORF as well as, surprisingly, many appearing in other ORFs. Phenotypic analysis revealed that either of two competing mutations in the virus transcription antitermination factor M2-1, outside of the CPD area, substantially reversed defective transcription of the CPD L gene and substantially restored virus fitness in vitro and in case of one of these two mutations, also in vivo. Paradoxically, the introduction into Min L of one mutation each in the M2-1, N, P, and L proteins resulted in a virus with increased attenuation in vivo but increased immunogenicity. Thus, in addition to providing insights on the adaptability of genome-scale deoptimized RNA viruses, stability studies can yield improved synthetic RNA virus vaccine candidates.
Adsorption of Water Vapor on Carbon Molecular Sieve: Thermal and Electrothermal Regeneration Study (2011)

In this work, we studied the safety issues related to the application of electric swing adsorption (ESA) processes to streams with high relative humidity. Carbon molecular sieve 3K was chosen as the selective adsorbent because of its good electricity-conducting properties. We also measured breakthrough curves of water vapor at different temperatures (296−347 K) using different partial pressures of water vapor. Additionally, a comparison of the performance of electric swing adsorption (ESA) and temperature swing adsorption (TSA) processes was also performed. The ESA experiments performed confirm that it is possible to employ the ESA technique in separations in which the feed streams are saturated with water.
Abstract 2597: Centralized and Study-specific Phenotyping in a Large-scale Stroke Genetics Study: An Analysis from the NINDS Stroke Genetics Network (SiGN) (2012)

Background: The Stroke Genetics Network (SiGN) funded by the NINDS aims to identify genetic risk factors in ischemic stroke using whole-genome association studies (GWAS). High quality phenotyping is crucial to successful application of GWAS. As a heterogenous disorder, stroke poses specific challenges. The Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification is a broadly used, but its validity is challenged especially when performed by multiple investigators with differing interpretations of the system. The Causative Classification System for Ischemic Stroke (CCS) system is a new, web-based, and computerized algorithm that integrates clinical, diagnostic, and etiologic stroke characteristics in an evidence-based manner ( ccs.mgh.harvard.edu ) to generate subtypes. Methods: In planning the SiGN proposal, a sample of 20 coded charts were collected from a subset of participating studies to assess feasibility of central adjudication and comparability to study-specific TOAST. Two central adjudicators reviewed all records and generated TOAST and CCS subtypes. These were compared to study-specific TOAST subtype and the CCS phenotype generated for SiGN by local trained adjudicators. CCS data is now available for 7134 included cases using both a 5 and a 7 category system as defined in the table . Results: All 4 phenotypes were available for 115 ischemic stroke cases from 6 studies in SiGN. Basic demographics were 54% women, 63% white, and median age between 65-74. Table 1 provides the agreement between the various subtypes. Table 2 describes the types of disagreement. Conclusions: Central adjudication with only two adjudicators and curated medical records yielded more consistent subtyping independent of phenotyping system. The agreement for TOAST was higher than published rates by independent groups (∼0.50). In contrast, the agreement for CCS was lower than previously published (0.85-0.95). Site adjudicators' familiarity with TOAST and inexperience with CCS may contribute. Although CCS is an automated algorithm and has a number of user friendly features, our findings suggest that formal training and certification process before starting to use CCS may be worthwhile to achieve optimal benefit from the system.
Electrical and optical properties of point defects in ZnO thin films (2012)

Abstract We show that the deposition of ZnO films under varying oxygen partial pressure and annealing conditions allows for the controllable formation of specific defects. Using x-ray diffraction and photoluminescence, we characterize the defects formed and show that these defects are responsible for changes in film carrier density, carrier type, sheet resistivity and mobility.