gebhart/patrepeval huggingface dataset:
SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells (2016)

In this report, we show that malignant pleural mesothelioma (MPM) patients whose tumors express high levels of AKT1 exhibit a significantly worse prognosis, whereas no significant correlation with AKT3 expression is observed. We provide data that establish a phosphorylation independent role of AKT1 in affecting MPM cell shape and anchorage independent cell growth in vitro and highlight the AKT1 isoform-specific nature of these effects.We describe that AKT1 activity is inhibited by the loss of SIRT1-mediated deacetylation and identify, by mass spectrometry, 11 unique proteins that interact with acetylated AKT1.Our data demonstrate a role of the AKT1/SIRT1/FOXM1 axis in the expression of the tumor suppressor ERβ. We further demonstrate an inhibitory feedback loop by ERβ, activated by the selective agonist KB9520, on this axis both in vitro and in vivo.Our data broaden the current knowledge of ERβ and AKT isoform-specific functions that could be valuable in the design of novel and effective therapeutic strategies for MPM.
Influence of Dose, Cigarette Smoking, Age, Sex, and Metabolic Activity on Plasma Clozapine Concentrations (2004)

The measurement of plasma clozapine concentrations is useful in assessing compliance, optimizing therapy, and minimizing toxicity. We measured plasma clozapine and norclozapine (N-desmethylclozapine) concentrations in samples from 3782 patients (2648 male, 1127 female). No clozapine was detected in 291 samples (227 patients, median prescribed dose 300 mg/d). In 4963 (50.2 %) samples (2222 patients); plasma clozapine concentration ranged from 10 to 350 ng/mL.Step-wise backward multiple regression analysis (37 % of the total samples) of log10 plasma clozapine concentration against log10 clozapine dose (mg/d), age (year), sex (male = 0, female = 1), cigarette smoking habit (nonsmokers = 0; smokers = 1), body weight (kg), and plasma clozapine/norclozapine ratio (clozapine metabolic ratio, MR) showed that these covariates explained 48% of the observed variation in plasma clozapine concentration (C = ng/mL x 10-3) (P < 0.001) according to the following equation: log 10 (C) = 0.811 log 10 (dose) + 0.332 (MR) + 69.42 X 10 (-3) (sex) + 2.263 x 10 (-3) (age) + 1.976 x 10(-3) (weight) - 0.171 (smoking habit) - 3.180. This model and its associated confidence intervals were used to develop nomograms of plasma clozapine concentration versus dose for male and female smokers and nonsmokers. Predicted plasma clozapine changes by +48% in nonsmokers, +17% in females, +/-8 % for every 0.1 change in MR (reference 1.32), +/-4% for every 5 years (reference 40 years), and +/-5 % for every 10 kg body weight (reference 80 kg). The nomograms can be used (i) to individualize dosage to achieve a given target plasma clozapine concentration, and (ii) for quantitative evaluation of adherence by estimating the likelihood of an observed concentration being achieved by a given dosage regimen. The model has been validated against published data.
Digital Ira (2013)

Overview In 2008, the "Digital Emily" project [Alexander et al. 2009] showed how a set of high-resolution facial expressions scanned in a light stage could be rigged into a real-time photoreal digital character and driven with video-based facial animation techniques. However, Digital Emily was rendered offline, involved just the front of the face, and was never seen in a tight closeup. In this collaboration between Activision and USC ICT shown at SIGGRAPH 2013's Real-Time Live venue, we endeavoured to create a real-time, photoreal digital human character which could be seen from any viewpoint, in any lighting, and could perform realistically from video performance capture even in a tight closeup. In addition, we wanted this to run in a real-time game-ready production pipeline, ultimately achieving 180 frames per second for a full-screen character on a two-year old graphics card.
Effects of Carbon Dioxide (CO 2 ) Laser Perforation as Skin Pretreatment to Improve Sugar Infusion Process of Frozen Blueberries (2012)

CO(2) laser perforation as a novel skin pretreatment for sugar infusion of individually quick frozen (IQF) blueberries is presented. The technique markedly improves the product yield and quality. Although further investigation is needed, the method may potentially be used for other waxy skin fruits such as cranberries and cherries.
Circulating MicroRNAs: Association with Lung Function in Asthma (2016)

Circulating microRNAs reflect asthma biology and are associated with lung function differences in asthmatics. They may represent biomarkers of asthma severity.
Bacterial viability and antibiotic susceptibility testing with SYTOX green nucleic acid stain (1997)

A fluorescent nucleic acid stain that does not penetrate living cells was used to assess the integrity of the plasma membranes of bacteria. SYTOX Green nucleic acid stain is an unsymmetrical cyanine dye with three positive charges that is completely excluded from live eukaryotic and prokaryotic cells. Binding of SYTOX Green stain to nucleic acids resulted in a > 500-fold enhancement in fluorescence emission (absorption and emission maxima at 502 and 523 nm, respectively), rendering bacteria with compromised plasma membranes brightly green fluorescent. SYTOX Green stain is readily excited by the 488-nm line of the argon ion laser. The fluorescence signal from membrane-compromised bacteria labeled with SYTOX Green stain was typically > 10-fold brighter than that from intact organisms. Bacterial suspensions labeled with SYTOX Green stain emitted green fluorescence in proportion to the fraction of permeabilized cells in the population, which was quantified by microscopy, fluorometry, or flow cytometry. Flow cytometric and fluorometric approaches were used to quantify the effect of beta-lactam antibiotics on the cell membrane integrity of Escherichia coli. Detection and discrimination of live and permeabilized cells labeled with SYTOX Green stain by flow cytometry were markedly improved over those by propidium iodide-based tests. These studies showed that bacterial labeling with SYTOX Green stain is an effective alternative to conventional methods for measuring bacterial viability and antibiotic susceptibility.
Flexible Control of an Organic Matrix Composite Cure Process using Object-Oriented Control Concepts (1990)

Rule-based expert systems for controlling the curing of organic matrix composites have demonstrated the ability to process a part according to the specific requirements of a part's materials and geometry. This paper describes an extension to this methodology using an object-oriented approach to develop a highly flexible, on-line control strategy which can be quickly configured to accommodate a variety of production loads.
A Software Defined Networking architecture for the Internet-of-Things (2014)

The growing interest in the Internet of Things (IoT) has resulted in a number of wide-area deployments of IoT subnetworks, where multiple heterogeneous wireless communication solutions coexist: from multiple access technologies such as cellular, WiFi, ZigBee, and Bluetooth, to multi-hop ad-hoc and MANET routing protocols, they all must be effectively integrated to create a seamless communication platform. Managing these open, geographically distributed, and heterogeneous networking infrastructures, especially in dynamic environments, is a key technical challenge. In order to take full advantage of the many opportunities they provide, techniques to concurrently provision the different classes of IoT traffic across a common set of sensors and networking resources must be designed. In this paper, we will design a software-defined approach for the IoT environment to dynamically achieve differentiated quality levels to different IoT tasks in very heterogeneous wireless networking scenarios. For this, we extend the Multinetwork INformation Architecture (MINA), a reflective (self-observing and adapting via an embodied Observe-Analyze-Adapt loop) middleware with a layered IoT SDN controller. The developed IoT SDN controller originally i) incorporates and supports commands to differentiate flow scheduling over task-level, multi-hop, and heterogeneous ad-hoc paths and ii) exploits Network Calculus and Genetic Algorithms to optimize the usage of currently available IoT network opportunities. We have applied the extended MINA SDN prototype in the challenging IoT scenario of wide-scale integration of electric vehicles, electric charging sites, smart grid infrastructures, and a wide set of pilot users, as targeted by the Artemis Internet of Energy and Arrowhead projects. Preliminary simulation performance results indicate that our approach and the extended MINA system can support efficient exploitation of the IoT multinetwork capabilities.
Structure and Expression of the Rice Glutelin Multigene Family (1989)

A near full-length cDNA and three genomic clones for rice (Oryza sativa L.) glutelin were isolated and studied. Based on nucleic acid sequence and Southern blot analyses, the three isolated glutelin genomic clones were representative members of three gene subfamilies each containing five to eight copies. A comparison of DNA sequences displayed by relevant regions of these genomic clones showed that two subfamilies, represented by clones Gt1 and Gt2, were closely related and evolved by more recent gene duplication events. The 5'-flanking and coding sequences of Gt1 and Gt2 displayed at least 87% homology. In contrast, Gt3 showed little or no homology in the 5'-flanking sequences upstream of the putative CAAT boxes and exhibited significant divergence in all other portions of the gene. Conserved sequences in the 5'-flanking regions of these genes were identified and discussed in light of their potential regulatory role. The derived primary sequences of all three glutelin genomic clones showed significant homology to the legume 11 S storage proteins indicating a common gene origin. A comparison of the derived glutelin primary sequences showed that mutations were clustered in three peptide regions. One peptide region corresponded to the highly mutable hypervariable region of legume 11 S storage proteins, a potential target area for protein modification. Expression studies indicated that glutelin mRNA transcripts are differentially accumulated during endosperm development. Promoters of Gt2 and Gt3 were functional as they direct transient expression of chloramphenicol acetyltransferase in cultured plant cells.
IMPARTE EL CHOPO TALLER DE BURLESQUE (2008)

COMO PARTE DE LA SEMANA CULTURAL LESBICA-GAY, EL MUSEO UNIVERSITARIO DEL CHOPO ORGANIZO EL TALLER DE BURLESQUE, DONDE SE DAN A CONOCER ANTECEDENTES, TEORIA Y PR CTICA ACTUAL DE ESTE ESPECT CULO, CON EL PROPOSITO DE QUE LOS PARTICIPANTES APRENDAN A CREAR SU PROPIO MONTAJE PARA PRESENTARLO EN UN RECITAL FINAL. EL COLECTIVO BURLESQUIMERAS -INTEGRADO POR FABIOLA JIMENEZ, KARINA GUZM N Y LA ARTISTA NEOYORKINA OLD MA FEMME- IMPARTE HASTA EL 4 DE JULIO ESTE TALLER EN EL CHOPO. EL BURLESQUE SE REFIERE A ESPECT CULOS TEATRALES QUE SUELEN CONSISTIR EN HISTORIETAS DE PARODIA. ALGUNOS AUTORES AFIRMAN QUE ES UN DESCENDIENTE DIRECTO DE LA COMEDIA DEL ARTE. EN LOS COMIENZOS DEL SIGLO XX SURGIO EL BURLESCO POPULISTA COMO UNA MEZCLA DE S TIRA, PERFORMANCE Y ENTRETENIMIENTO PARA ADULTOS, QUE INCLUIA ACTUACIONES PARA MOLESTAR O INCOMODAR AL PUBLICO. DE HECHO, BURLESQUE SIGNIFICA BOCA ABAJO, E IGUAL QUE SU GENERO PRIMO, LA COMEDIA DEL ARTE, LAS NORMAS SOCIALES SE CONVIERTEN EN OBJETO DE CRITICA. LOS INTERPRETES POR LO GENERAL SON MUJERES, A MENUDO FORMAN COROS O GRUPOS CON EXUBERANTES Y COLORIDOS TRAJES, CON UN ESTADO DE  NIMO APROPIADO PARA LA MUSICA Y LA ILUMINACION ESPECTACULAR, E INCLUSO SE AGREGAN ACTUACIONES CON FUEGO Y CONTORSIONISMO. EL TALLER DA A CONOCER EL GENERO DE NEOBURLESQUE COMO UNA FORMA DE EMPODERAMIENTO DEL CUERPO. ESTE GENERO, POCO CONOCIDO EN MEXICO, ES UNA CORRIENTE QUE TIENE CERCA DE TRES ANOS EN CIUDADES COMO BERLIN, SAN DIEGO Y NUEVA YORK, Y, AL IGUAL QUE EL ORIGINAL, UTILIZA UNA PIEZA MUSICAL, UNA HISTORIA Y EL STRIPTEASE, SIN EMBARGO, SU PROPUESTA POLITICA EMPIEZA Y SE REALZA CON EL PROPIO CUERPO COMO MEDIO DE EXPRESION, SOBRE TODO SI NO CORRESPONDE CON EL ESTEREOTIPO DE LA MODA. IGUALMENTE EL TEMA QUE TRATA TIENE QUE VER CON LA DIVERSIDAD SEXUAL. EL TALLER COMPRENDE CUATRO GRANDES TEMAS: HISTORIA DEL BURLESQUE, EL BURLESQUE COMO EXPRESION ARTISTICA, CREACION DEL CHOU Y ORGANIZACION DEL RECITAL. SE IMPARTE EN DOCTOR ATL 39, COLONIA SANTA MARIA LA RIBERA, RESIDENCIAS FRANCO, CASA 11, SALON 3. INFORMES EN EL DEPARTAMENTO DE DIFUSION A LOS TELEFONOS 5535 2186, 5535 2288, EXTENSION 123 SANTISIM@SERVIDOR.
ChemInform Abstract: Antibody Catalyzed Modification of Amino Acids. Efficient Hydrolysis of Tyrosine Benzoate. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cleavage mechanism of human Mus81–Eme1 acting on Holliday-junction structures (2008)

Recombination-mediated repair plays a central role in maintaining genomic integrity during DNA replication. The human Mus81-Eme1 endonuclease is involved in recombination repair, but the exact structures it acts on in vivo are not known. Using kinetic and enzymatic analysis of highly purified recombinant enzyme, we find that Mus81-Eme1 catalyzes coordinate bilateral cleavage of model Holliday-junction structures. Using a self-limiting, cruciform-containing substrate, we demonstrate that bilateral cleavage occurs sequentially within the lifetime of the enzyme-substrate complex. Coordinate bilateral cleavage is promoted by the highly cooperative nature of the enzyme and results in symmetrical cleavage of a cruciform structure, thus, Mus81-Eme1 can ensure coordinate, bilateral cleavage of Holliday junction-like structures.
Ribosomal incorporation of backbone modified amino acids via an editing-deficient aminoacyl-tRNA synthetase (2018)

The ability to incorporate non-canonical amino acids (ncAA) using translation offers researchers the ability to extend the functionality of proteins and peptides for many applications including synthetic biology, biophysical and structural studies, and discovery of novel ligands. Here we describe the high promiscuity of an editing-deficient valine-tRNA synthetase (ValRS T222P). Using this enzyme, we demonstrate ribosomal translation of 11 ncAAs including those with novel side chains, α,α-disubstitutions, and cyclic β-amino acids.
Mousebuster: a robot system for catching fast moving objects by vision (2002)

A control methodology for catching a fast moving object with a robot manipulator, where visual information is employed to track the trajectory of the target, is described. Sensing, planning, and control are performed in real-time to cope with possible unpredictable trajectory changes of the moving target. Prediction techniques are adopted to compensate for the time delays introduced by visual processing and by the robot controller. A simple, reliable model of the robot controller is used in the control architecture for improving the performance of the system. Experimental results show that the robot system is capable of tracking and catching an object moving on a plane at velocities of up to 700 mm/s and accelerations of up to 1500 mm/s/sup 2/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Synthesis and Stereospecificity of 4,5-Disubstituted Oxazolidinone Ligands Binding to T-box Riboswitch RNA (2011)

The enantiomers and the cis isomers of two previously studied 4,5-disubstituted oxazolidinones have been synthesized, and their binding to the T-box riboswitch antiterminator model RNA has been investigated in detail. Characterization of ligand affinities and binding site localization indicates that there is little stereospecific discrimination for binding antiterminator RNA alone. This binding similarity between enantiomers is likely due to surface binding, which accommodates ligand conformations that result in comparable ligand-antiterminator contacts. These results have significant implications for T-box antiterminator-targeted drug discovery and, in general, for targeting other medicinally relevant RNA that do not present deep binding pockets.
μ-Bis(diphenylphosphino)ethane-P,P′-bis[bis(O-isopropyldithiocarbonato-S,S′)zinc(II)] (2002)

The molecular structure of the title compound, [Zn2(C4H7OS2)4(C26H24P2)], features two Zn(S2COiPr)2 units bridged by a diphosphine ligand. The thiol­ate ligands are chelating but form asymmetric Zn—S bonds, introducing considerable distortion in the coordination geometry about Zn that is intermediate between square pyramidal and trigonal bipyramidal.
Predictive control of diffusion-reaction processes (2005)

This paper focuses on the development of computationally-efficient predictive control algorithms for nonlinear parabolic PDEs with state and control constraints arising in the context of diffusion-reaction processes. Specifically, we consider a diffusion-reaction process described by a nonlinear parabolic PDE and address the problem of stabilization of an unstable steady-state subject to input and state constraints. Galerkin's method is used to derive finite-dimensional systems that capture the dominant dynamics of the parabolic PDF, which are subsequently used for controller design. Various MPC formulations are constructed on the basis of the finite dimensional approximations that differ in the way the evolution of the fast eigenmodes is accounted for in the performance objective and state constraints. The impact of these differences on the ability of the predictive controller to enforce state constraints satisfaction in the infinite-dimensional system is analyzed. Finally, the MPC formulations arc applied, through simulation, to the problem of stabilizing an unstable steady-state of a nonlinear model of a diffusion-reaction process subject to state and control constraints.
New insights in vulcanization chemistry using microwaves as heating source (2008)

La vulcanitzacio per microones es un proces madur i no hi ha dubte sobre la seva eficiencia per produir articles de cautxu d'alta qualitat. Les microones son conegudes no nomes per la seva capacitat d'accelerar els processos i augmentar la eficiencia de la transferencia energetica, sino que tambe son capaces en certs casos de canviar els camins de reaccio. Hi ha evidencies, basades en canvis en propietats fisiques al comparar productes vulcanitzats amb el metode convencional i amb microones, que indiquen que alguns canvis poden succeir al treballar amb diferents fonts d'escalfament. No obstant aixo, hi ha una falta d'informacio sobre els efectes que les microones tenen en la quimica de la vulcanitzacio. Per tant, el principal objectiu d'aquesta tesi es basa en estudiar la vulcanitzacio assistida amb microones des d'una nova perspectiva, centrant-se en els efectes d'aquesta radiacio en els ingredients principals de les formulacions de cautxu, en el mecanisme de vulcanitzacio, en la reticulacio de la xarxa polimerica i tambe en el proces de devulcanitzacio.La primera part de la feina va consistir en desenvolupar i optimitzar tots els metodes analitics necessaris per explorar totes les etapes del proces de vulcanitzacio i identificar tots els intermedis formats. Estudis de Model Compound Vulcanization (MCV) utilitzant esquale com a molecula model s'han realitzat per entendre millor la influencia d'aquesta radiacio en el mecanisme de la reaccio, encara que alguns experiments tambe s'han realitzat amb mostres de cautxu natural. Tecniques com HPLC-MS, MALDI-TOF o GPC s'han utilitzat per caracteritzar les mostres de MCV, mentre que mesures d'inflament, de tensio-elongacio, compressio i duresa s'han realitzat per caracteritzar les mostres de cautxu natural.Dos dels sistemes de vulcanitzacio mes comuns han estat estudiats (sulfenamides i tiurams). A mes, s'ha donat un especial emfasi a l'estudi de la influencia de les microones en el sistema activador, intentant reduir el contingut de ZnO i cercar, a traves de diverses estrategies, substituts mes amigables amb el medi ambient. Finalment, tot el coneixement adquirit en aquests estudis s'ha utilitzat per optimitzar el comportament devulcanitzant del disulfur de difenil (DPDS) amb l'ajut de les microones, demostrant que les microones poden ajudar a avancar en la recerca d'una solucio al problema del reciclatge dels residus de cautxu.
Pneumococcal infections in HIV-infected adults. (1999)

Bacterial pneumonia, specifically pneumococcal infection, is a frequent cause of morbidity and mortality in persons infected with human immunodeficiency virus (HIV). It causes morbidity directly and possibly progression of HIV infection. The clinical presentation and response to therapy are usually similar to that of patients without HIV infection, although radiographic presentations may be atypical. There is a higher incidence of invasive disease and extrapulmonary disease, and mortality may be increased in HIV-infected patients. HIV infection impairs the host response to pneumococcus in a variety of ways. Colonization with Streptococcus pneumoniae may be prolonged for reasons that are incompletely understood. Concern about the rising prevalence of resistant pneumococcal strains is increasing, but the clinical relevance is uncertain. At least 90% of the strains that cause invasive disease are present in the 23-valent pneumococcal vaccine. The response to vaccination declines as immunodeficiency progresses; however, the potential benefit to responders is great and the risk is minimal. Therefore, this vaccine is recommended for all HIV-infected persons.
Design and analysis of new generation protocols for triple-play networks (2010)

Transmission Control Protocol (TCP)&apos;s proven stability and scalability has made it the most widely used transport layer protocol for more than twenty years. However, as multimedia applications become ubiquitous over the internet, TCP has been found incapable of meeting their requirements, which place more emphasis on timeliness than on reliability. Because of that, many multimedia applications turn to UDP as their underlying transport protocol. However, the majority of video on demand and live broadcast applications predominantly use TCP over UDP (User Datagram Protocol), due to UDP&apos;s unresponsiveness to network conditions and problems with firewalls and NATs (Network Address Translations). TCP&apos;s poor performance in delivering real-time media is due to the following reasons: 1) TCP&apos;s emphasis on reliable in-order delivery causes frame jitter that interrupt media play out. 2) TCP&apos;s coarse-grained retransmission timeout (RTO) and its back-off mechanism is detrimental to any real-time based application. In this study, we propose a new variant of TCP with an early retransmission scheme as an enhancement to make it more suitable for streaming media. We call this new protocol TCP-ER. We performed extensive NS-2 simulations to show that: 1) the early retransmission scheme can reduce the number of retransmission timeouts in a variety of network environments, which results in a considerable decrease in number of retransmission timeouts and packet delay jitter. 2) Under same network conditions, constrained streaming over TCP-ER has a considerably lower number of late packets than its normal TCP counterpart. 3) TCP-ER has a higher throughput in severely congested network conditions, whereas it stays relatively fair with typical TCP implementations (specifically TCP-SACK) as congestion gets alleviated.