gebhart/patrepeval huggingface dataset:
Composite Constituents: Three New Triterpene Triols Isolated from Fresh Roots of Picris hieracioides subsp. japonica. (1995)

Three new triterpenoids, olean-12-ene-2β, 3β, 22α-triol (1), urs-12-ene-2β, 3β, 22α-triol (2), urs-12-ene-2β, 3β, 28-triol (3), and a known one, olean-12-ene-2β, 3β, 28-triol (4), were isolated from the fresh roots of Picris hieracioides subsp. japonica, and their structures were elucidated on the basis of spectral data.
Services Provisioning on Mobile Devices via Bluetooth in a Localized Setting Using a Proposed System - BTServ (2008)

Conventionally, enterprise services that can be utilized by mobile devices such as E - mail, instant messaging, data transfer, news and event notification have been typically achieved using GPRS (General Packet Radio Service) connections to access internet servers that provide these services. Thus, even in a local area, disadvantages such as full dependence on GPRS service providers, incurred GPRS costs and slow data/communication rates constitute formidable drawbacks. This paper describes a system /Architecture (BTServ) in which these same services can be supplied via Bluetooth, with notable benefits such as high data rates, minimal dependence on external (GPRS) networks, higher security (internet attacks are totally avoided) and reduced cost, in a localized setting such as a corporate house.
Comparison of Fumed and Colloidal External Additives for Toner (2010)

External additives play a very important role in the performance of toner. They were originally used to adjust the toner freeflow and fine-tune its tribocharging performance. Recent trends towards color chemically produced toner have brought changes in the toner particle size and its composition. These changes have put even higher performance demands on the additives. For example, larger contribution to the tribocharging control for both positive and negative charging toner, requirements for spacing and durability for dual component toner, control of surface energy for more efficient toner transfer. Cabot offers a portfolio of modified silica additives that cover a unique range of morphologies, particle sizes and surface chemistries. In this paper we will compare the performance of treated silica additives with similar surface chemistries and different morphologies to explore some of the similarities and differences of colloidal and fumed silica-based products. Coverage, tribocharging, and freeflow are the key functions that are studied for dual component negative toner systems.
High Mobility Field Effect Transistors Based on Macroscopically Oriented Regioregular Copolymers (2012)

Field-effect transistors fabricated from semiconducting conjugated polymers are candidates for flexible and low-cost electronic applications. Here, we demonstrate that the mobility of high molecular weight (300 kDa) regioregular, poly[4-(4,4-dihexadecyl-4H-cyclopenta[1,2-b:5,4-b']dithiophen-2-yl)-alt-[1,2,5]thiadiazolo[3,4-c]pyridine] can be significantly improved by introducing long-range orientation of the polymer chains. By annealing for short periods, hole mobilities of 6.7 cm(2)/(V s) have been demonstrated. The transport is anisotropic, with a higher mobility (approximately 6:1) parallel to the polymer backbone than that perpendicular to the polymer backbone.
Commissioning of Vertical Test Stand Facility for 2 K Testing of Superconducting Cavities at RRCAT (2014)

Raja Ramanna Centre for Advanced Technology (RRCAT) has developed a 2K vertical Test Stand (VTS) facility for characterization of Superconducting RF (SCRF) cavities, under Indian Institution Fermilab Collaboration (IIFC). The VTS facility comprises of a large size liquid helium (LHe) cryostat, cryogenic system, RF power supply, control and data acquisition system and radiation monitoring system. It will facilitate testing of superconducting cavities of different frequencies ranging from 325 MHz low beta to 650 MHz / 1.3 GHz medium and high beta cavities. The helium vessel has a capacity to store up to 2900 litres of liquid Helium. The cryostat is installed inside a vertical pit. It is equipped with facilities for supply of liquid nitrogen and liquid helium and vacuum system for pumping out helium gas to lower the temperature of liquid helium bath down to 1.8 K. A 200 W, 1.3 GHz RF system has been indigenously developed for testing of the SCRF cavities. The VTS facility has now been commissioned and its performance validation has been successfully carried out by benchmarking it with respect to the facility at the Fermilab.
Cover Picture: Macromol. Symp. 239/2006 (2006)

Cover: Advancement in modern po lymer technologies such as photo‐electronics, pharmaceutical and biomedical fields, biodegradable systems and specific composites are increasingly interrelated. Urgent demands are apparent for new, eco‐efficient, advanced polymer systems, the development of which requires interdisciplinary knowledge. The common thinking of scientists specialized in certain segments of polymer science and technology was strongly initiated by the 8 th International Symposium on Polymers for Advanced Technologies (PAT 2005) held in Budapest, September 2005. Convergent concepts can be seen in the developments of materials to be used as pharmaceuticals, biomaterials, polymer composites, fire retarded polymers, membranes, conductive systems and fuel cells. The presented unusual ways for various technologies of advanced polymer systems may initiate further research activities in the near future. Responding to the demand for better understanding of the advanced materials the conference covered the mechanistic and technological aspects of syntheses, composite and nanocomposite formation, and behaviour of polymeric materials in biomedical environment. As an example, the picture shows an SEM micrograph of carbon nanofibers in sPP (filler content: 0,6 %), taken from the contribution by W. Kaminsky.
Effects of Instrument-measuring Geometry on Colorimetric Assessments of Dental Porcelains (1990)

Recent developments in optical electronic instrumentation for color control have made the potential use of clinical photometric analysis a future possibility for dental materials selection and custom restoration design. The development of such instrumentation will require a more complete understanding of the performance of current technologies on translucent materials. This study was designed to evaluate the effects of instrument-measuring geometry on color-difference assessments made on dental porcelains. The results indicate that a high degree of correlation can exist between color-difference measurements regardless of the design of the instrument-measuring geometry. This work suggests that the development of clinically useful devices need not be restricted to more traditional integrating-sphere-type designs and that more photometrically efficient alternative designs should be explored.
ChemInform Abstract: Functionalization of the Anomeric C—H Bond of Carbohydrates: Old Strategies and New Opportunities (2014)

Abstract Review: &lt;100 refs.
Physical Features and Vital Signs Predict Serum Albumin and Globulin Concentrations Using Machine Learning (2021)

Our models predicted serum protein concentrations with appreciable accuracy showing the promise of this approach. Such models could serve to augment existing tools for identifying "at-risk" individuals for follow-up with a blood test.
Gastrointestinal Quality of Life Improvement of Renal Transplant Recipients Converted From Mycophenolate Mofetil to Enteric-Coated Mycophenolate Sodium Drugs or Agents: Mycophenolate Mofetil and Enteric-Coated Mycophenolate Sodium (2011)

In RT patients with GI undesirable effects due to MMF, switching from MMF to EC-MPS may enable an increase in the maximum tolerated dose of mycophenolic acid and reduce GI complications, thus enhancing patients' GI HRQoL.
Embedded NiTi Wires for Improved Dynamic Thermomechanical Performance of Silicone Elastomers (2020)

The extraordinary properties of shape memory NiTi alloy are combined with the inherent viscoelastic behavior of a silicon elastomer. NiTi wires are incorporated in a silicon elastomer matrix. Benefits include features as electrical/thermal conductivity, reinforcement along with enhanced damping performance and flexibility. To gain more insight of this composite, a comprehensive dynamic thermomechanical analysis is performed and the temperature- as well as frequency-dependent storage modulus and the mechanical loss factor are obtained. The analyses are realized for the composite and single components. Moreover, the models to express the examined properties and their temperature along with the frequency dependencies are also presented.
Learning Dependency Translation Models as Collections of Finite-State Head Transducers (2000)

The paper defines weighted head transducers, finite-state machines that perform middle-out string transduction. These transducers are strictly more expressive than the special case of standard left-to-right finite-state transducers. Dependency transduction models are then defined as collections of weighted head transducers that are applied hierarchically. A dynamic programming search algorithm is described for finding the optimal transduction of an input string with respect to a dependency transduction model. A method for automatically training a dependency transduction model from a set of input-output example strings is presented. The method first searches for hierarchical alignments of the training examples guided by correlation statistics, and then constructs the transitions of head transducers that are consistent with these alignments. Experimental results are given for applying the training method to translation from English to Spanish and Japanese.
Persistent functional and structural retinal anomalies in newborn rats exposed to hyperoxia (1999)

Previous studies have shown that newborn rats exposed postnatally to hyperoxia will develop a permanent impairment of the retinal function as determined with the electroretinogram (ERG). The purpose of our study was to examine whether postnatal hyperoxia equally alters the light- and dark-adapted ERGs and oscillatory potentials (OPs) as well as leads to permanent structural modification of the retina. During the first 14 days of life, cohorts of Sprague-Dawley rats were exposed to a hyperoxic environment, and ERGs were recorded at mean ages of approximately 25 and 55 days. Our results indicate that both light- and dark-adapted ERGs and OPs are already significantly altered within a few days following exposure to hyperoxia. None of the ERG and (or) OP parameters, with the exception of the a-wave, returned to normal values by 55 days of age. In fact some dark-adapted OPs were completely abolished following postnatal O2 exposure. Histological analysis revealed that the retina of rats exposed to hyperoxia failed to develop an outer plexiform layer and had a reduced count of horizontal cells, consistent with the permanent postreceptoral anomalies seen in the ERG responses. Our results suggest that postnatal hyperoxia causes a generalized retinal disorder leading to permanent structural modifications of the retinal cytoarchitecture and lasting anomalies of the rod and cone functions.
Antioxidant activity and hypoglycemic effect of ferulic acid in STZ‐induced diabetic mice and KK‐Ay mice (2004)

Antioxidant activity and biological properties of ferulic acid (FA) are well recognized. This study was designed to estimate the potential utility of FA administered orally at low dosage for improvement of hyperglycemia in diabetes. With this aim we have evaluated the hypoglycemic effect of FA in two type diabetic animal models: (1) streptozotocin (STZ)-induced diabetic mice, a model of insulin-dependent diabetes mellitus (IDDM); (2) KK-Ay mice, a model of non-insulin dependent diabetes mellitus (NIDDM). In addition, we measured the production of thiobarbituric acid-reactive substances (TBARS) in brown adipose tissues of diabetic mice at the end of FA feeding experiment. FA at 0.01% and 0.1% of basal diet showed to suppress significantly blood glucose levels in STZ-induced diabetic mice. In KK-Ay mice 0.05% FA suppressed effectively blood glucose levels. In addition, FA inhibited the lipid peroxidation in brown adipose tissue of diabetic mice. Taken together, these findings suggest that dietary FA may be useful in alleviating oxidative stress and attenuating the hyperglycemic response associated with diabetes.
Sulindac Reverses Aberrant Expression and Localization of β-Catenin in Papillary Thyroid Cancer Cells with the BRAF V600E Mutation (2010)

Taken together, our findings demonstrate that sulindac treatment reverses beta-catenin activity in 8505-C and KTC-1 cell lines with the BRAF(V600E), but not in TPC-1 cells with the RET/PTC mutation. Future studies should investigate the potential for beta-catenin-directed therapy for patients with advanced thyroid cancers.
<em>In Vitro</em> Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells (2017)

The circadian rhythm is a fundamental physiological process present in all organisms that regulates biological processes ranging from gene expression to sleep behavior. In vertebrates, circadian rhythm is controlled by a molecular oscillator that functions in both the suprachiasmatic nucleus (SCN; central pacemaker) and individual cells comprising most peripheral tissues. More importantly, disruption of circadian rhythm by exposure to light-at-night, environmental stressors and/or toxicants is associated with increased risk of chronic diseases and aging. The ability to identify agents that can disrupt central and/or peripheral biological clocks, and agents that can prevent or mitigate the effects of circadian disruption, has significant implications for prevention of chronic diseases. Although rodent models can be used to identify exposures and agents that induce or prevent/mitigate circadian disruption, these experiments require large numbers of animals. In vivo studies also require significant resources and infrastructure, and require researchers to work all night. Thus, there is an urgent need for a cell-type appropriate in vitro system to screen for environmental circadian disruptors and enhancers in cell types from different organs and disease states. We constructed a vector that drives transcription of the destabilized luciferase in eukaryotic cells under the control of the human PERIOD 2 gene promoter. This circadian reporter construct was stably transfected into human mammary epithelial cells, and circadian responsive reporter cells were selected to develop the in vitro bioluminescence assay. Here, we present a detailed protocol to establish and validate the assay. We further provide details for proof of concept experiments demonstrating the ability of our in vitro assay to recapitulate the in vivo effects of various chemicals on the cellular biological clock. The results indicate that the assay can be adapted to a variety of cell types to screen for both environmental disruptors and chemopreventive enhancers of circadian clocks.
Zur Chemie der 1,3,5-Triaza-2-phosphorinan- 4,6-dione. Teil XIV. Darstellung von weiteren P-alkyl- und P-arylsubstituierten 1,3,5-Trimethyl-1,3,5-triaza-2-phosphorinan-4,6-dionen (2015)

Zusammenfassung: Die Reaktion von 1,5-Bis(trimethylsilyl)-1,3,5-trimethylbiuret mit Di- bzw. Monochlorphosphanen führte unter Bildung von Me 3 SiCl zu den 1,3,5-Trimethyl-1,3,5-triaza-2 σ 3 λ 3 -phosphorinan-4,6-dionen 1 – 4 bzw. zu den 1,5-Bis(phosphano)-1,3,5-trimethylbiuret-Derivativen 5 und 6 . Verbindungen 1 , 2 und 4 wurden mittels Einkristall-Röntgenstrukturanalyse charakterisiert. Alle Heterozyklen wiesen eine flache Boot-Konfiguration auf, wobei das Phosphoratom und das gegenüberstehende Stickstoffatom außerhalb der Ebene der restlichen Atome lagen. Oxidation der σ 3 λ 3 P-Derivative mit dem 1:1-Harnstoff/Wasserstoffperoxid-Addukt lieferte die entsprechenden 2-Oxo-2 σ 4 λ 5 -phosphorinan-4,6-dionen 8 – 11 und die 1,5-Bis(phosphoryl)biuret-Derivate 12 und 13 . Die Spirophosphorane 15 – 22 wurden bei der Reaktion von 1 – 4 mit Tetrachlor- o -benzochinon, und von 1 , 3 und 4 mit Hexafluoraceton gebildet. Verbindungen 20 und 21 enthalten einen Oxaphosphetanring, der durch die elektronegativen CF 3 -Gruppen stabilisiert wird. Verbindung 22 wurde aus 21 durch Verlust der Trimethylsilylgruppe gebildet.Außer 21 wurden alle Oxaphosphetane über ihre 1 H-, 13 C-, 19 F- und 31 P-NMR-Spektren und mittels E.I.-Massenspektrometrie characterisiert. Auch für 20 wurde eine Einkristall-Röntgenstrukturanalyse durchgeführt; die Koordination am Phosphor ist stark verzerrt trigonal bipyramidal, wobei der Oxetanring eine axiale und eine equatoriale Lage am Phosphor besetzt. Die Reaktion von 1 mit 1-Trifluormethyl-2-(heptafluorisopropyl)-biacetyl lieferte 23 anstatt eines Oxaphosphetans wie 20 .
ChemInform Abstract: The Effect of Vinyl Esters on the Enantioselectivity of the Lipase‐Catalyzed Transesterification of Alcohols. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Regulation of IL-4 lymphokine gene expression and cellular proliferation in murine T helper type II cells. (1990)

Activation of T cells results in the production of lymphokines and cellular proliferation. Protein kinase C (PKC) plays a key role in this process. It has been shown that this enzyme is essential to elicit a response to Con A or specific antigen in CD4+ T helper type 1 (Th 1) cells that secrete IL-2. We have now explored the signal transduction pathway that leads to transcription of the IL-4 gene and proliferation in murine CD4+ T helper type 2 (Th 2) cells. Surprisingly, we have found in two independently derived Th 2 clones that neither cellular proliferation nor IL-4 lymphokine production is affected by blocking or depletion of PKC. This differential mechanism of signal transmission leading to cellular activation implies a new distinction between murine Th 1 and Th 2 cells.
Outcome of patients with chronic myeloid leukemia with multiple ABL1 kinase domain mutations receiving tyrosine kinase inhibitor therapy (2011)

We investigated the impact of carrying more than one BCR-ABL1 mutation in 207 patients with chronic myeloid leukemia (102 chronic, 61 accelerated, and 44 blast phase) post-imatinib failure. Seven (8%) of 92 patients carrying mutations had more than one mutation: 4 (4%) in chronic phase, 2 (2%) in accelerated phase, and one (1 %) in blast phase. The cytogenetic response rate to second generation TKIs for patients with no, one, or more than one mutation was 88%, 69%, 50% (P=0.03) in chronic phase, 54%, 42%, 50% in accelerated phase (P=0.67), and 35%, 25%, 0% (P=0.63) in blast phase, respectively. No differences were observed in event free survival or overall survival in accelerated or blast phase according to their mutational status. However, the 4-year event free survival rates among patients in chronic phase with no, one, or more than one BCR-ABL1 mutation were 56%, 49%, and 0%, respectively (P=0.02), with overall survival rates of 91%, 69%, and 75%, respectively (P=0.13). In conclusion, patients with more than one BCR-ABL1 mutation fare worse than those with no or one mutation.
State of the art of Silicon Nitride photonics integration platforms (2017)

In this paper, a review of the current state of the art of Silicon Nitride photonics integration platforms is presented. These platforms are nowadays employed primarily for bio-photonics and telecom applications, ranging from the visible to the long near infrared. Prospects for the extension to mid- infrared wavelengths and applications are also presented and discussed.
Evaluation of the seismic performance of a code‐conforming reinforced‐concrete frame building—from seismic hazard to collapse safety and economic losses (2007)

Abstract A state‐of‐the‐art seismic performance assessment is illustrated through application to a reinforced‐concrete moment‐frame building designed per current (2003) building code provisions. Performance is quantified in terms of economic losses and collapse safety. The assessment includes site‐specific seismic hazard analyses, nonlinear dynamic structural response simulations to collapse, damage analyses, and loss estimation. When selecting ground motion records for nonlinear dynamic analyses that are consistent with a target hazard level expressed in terms of a response spectral value at the building's fundamental period, it is important to consider the response spectral shape, especially when considering higher hazard levels. This was done through the parameter commonly denoted by ε. Neglecting these effects during record selection is shown to lead to a factor of 5–10 overestimation of mean annual collapse rate. Structural response simulations, which properly account for uncertainties in ground motions and structural modelling, indicate a 2–7% probability of collapse for buildings subjected to motions scaled to a hazard level equivalent to a 2% probability of exceedance in 50 years. The probabilities of component damage and the means and coefficients of variation of the repair costs are calculated using fragility functions and repair‐cost probability distributions. The calculated expected annual losses for various building design variants range from 0.6 to 1.1% of the replacement value, where the smaller losses are for above‐code design variants and the larger losses are for buildings designed with minimum‐code compliance. Sensitivity studies highlight the impact of key modelling assumptions on the accurate calculation of damage and the associated repair costs. Copyright © 2007 John Wiley &amp; Sons, Ltd.
Time‐dependent lipid profile inversely associates with mortality in hemodialysis patients – independent of inflammation/malnutrition (2021)

Baseline and time-dependent lipid profile are inversely associated with mortality in a large, multicentre cohort of incident haemodialysis patients. Inflammation/malnutrition is not a confounder nor effect modificator of the associations between lipid profile and mortality in European haemodialysis patients.
Cyclophilin B Binding to Platelets Supports Calcium-Dependent Adhesion to Collagen (1999)

We have recently reported that cyclophilin B (CyPB), a secreted cyclosporine-binding protein, could bind to T lymphocytes through interactions with two types of binding sites. The first ones, referred to as type I, involve interactions with the conserved domain of CyPB and promote the endocytosis of surface-bound ligand, while the second type of binding sites, termed type II, are represented by glycosaminoglycans (GAG). Here, we further investigated the interactions of CyPB with blood cell populations. In addition to lymphocytes, CyPB was found to interact mainly with platelets. The binding is specific, with a dissociation constant (kd) of 9 +/- 3 nmol/L and the number of sites estimated at 960 +/- 60 per cell. Platelet glycosaminoglycans are not required for the interactions, but the binding is dramatically reduced by active cyclosporine derivatives. We then analyzed the biologic effects of CyPB and found a significant increase in platelet adhesion to collagen. Concurrently, CyPB initiates a transmembranous influx of Ca(2+) and induces the phosphorylation of the P-20 light chains of myosin. Taken together, the present results demonstrate for the first time that extracellular CyPB specifically interacts with platelets through a functional receptor related to the lymphocyte type I binding sites and might act by regulating the activity of a receptor-operated membrane Ca(2+) channel.