gebhart/patrepeval huggingface dataset:
Abstract 11766: 3d Strain in Evaluating of Left Ventricular Mechanical Function in Athletes (2014)

Introduction: Regular physical exercise induces morphological and functional heart’s modifications, the so called “athlete’s heart, whose characterization is based on morphology only. Hypothesis: The study aims to exploit the potential of 3D strain to improve the physiological understanding of LV functional changes in trained athletes. Methods: Three age-matched groups of young (age 20.3±5.4) individuals are prospectively enrolled: 13 normal healthy subjects (Controls), 15 professional athletes (Athletes), and 20 professional athletes with bicuspid aortic valve and low-to-mild aortic regurgitation (BAV Athletes). They underwent echocardiographic examination and both 2D and 3D strain analysis. Results: All echo parameters were within the normal range in the three groups. Global values of end-systolic longitudinal and circumferential strain, assesses by either 2D or 3D analysis, were not significantly different. The 3D strain analysis was extended in terms of principal and secondary strain (PS, SS). Global PS was not different, global SS was significantly higher in athletes (Controls: -6.6%±3.0, Athletes: -12.8%±2.8, BAV Athletes: -12.4%±6.3; p Conclusions: 3D strain analysis allows a deeper physiological understanding of LV contraction. Secondary strain, only available in 3D, detected improvement of performances in Athletes with normal systolic function. This appear to be a result of the synergic activation of endocardial and epicardial fibers, with minor differences in presence of BAV where exercise may play a protective role.
Prediction of Persistent Post-Concussion Symptoms after Mild Traumatic Brain Injury (2018)

Persistent post-concussion symptoms (PPCS) occur frequently after mild traumatic brain injury (mTBI). The identification of patients at risk for poor outcome remains challenging because valid prediction models are missing. The objectives of the current study were to assess the quality and clinical value of prediction models for PPCS and to develop a new model based on the synthesis of existing models and addition of complaints at the emergency department (ED). Patients with mTBI (Glasgow Coma Scale score 13-15) were recruited prospectively from three Dutch level I trauma centers between 2013 and 2015 in the UPFRONT study. PPCS were assessed using the Head Injury Severity Checklist at six months post-injury. Two prediction models (Stulemeijer 2008; Cnossen 2017) were examined for calibration and discrimination. The final model comprised variables of existing models with the addition of headache, nausea/vomiting, and neck pain at ED, using logistic regression and bootstrap validation. Overall, 591 patients (mean age 51years, 41% female) were included; PPCS developed in 241 (41%). Existing models performed poorly at external validation (area under the curve [AUC]: 0.57-0.64). The newly developed model included female sex (odds ratio [OR] 1.48, 95% confidence interval [CI] [1.01-2.18]), neck pain (OR 2.58, [1.39-4.78]), two-week post-concussion symptoms (OR 4.89, [3.19-7.49]) and two-week post-traumatic stress (OR 2.98, [1.88-4.73]) as significant predictors. Discrimination of this model was adequate (AUC after bootstrap validation: 0.75). Existing prediction models for PPCS perform poorly. A new model performs reasonably with predictive factors already discernible at ED warranting further external validation. Prediction research in mTBI should be improved by standardizing definitions and data collection and by using sound methodology.
Pathology-Optimized Open-top Light-sheet Microscopy (2018)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. K. Glaser and J. T. C. Liu, "Pathology-optimized open-top light-sheet microscopy," in Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), OSA Technical Digest (Optica Publishing Group, 2018), paper MTu2A.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
MYC + diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation (2012)

Approximately 5-10% of diffuse large B-cell lymphomas (DLBCL) harbor a 8q24/MYC rearrangement (MYC(+)). We determined the prognostic significance of MYC rearrangement in patients with relapsed/refractory DLBCL prospectively treated by R-ICE or R-DHAP followed by high-dose therapy and autologous stem cell transplantation. Twenty-eight (17%) of the 161 patients analyzed presented a MYC(+) rearrangement, targeted as either simple hit (25%) or complex hits (n=75%) including MYC/BCL2, MYC/BCL6, and MYC/BCL2/BCL6. Results were statistically highly concordant in matched primary and relapsed biopsies (n = 45). Compared to the MYC(-) DLBCL patients, the MYC(+) DLBCL patients presented with a more elevated lactico-deshydrogenase level (P = .0006) and a more advanced age adjusted international prognostic index (P = .0039). The 4-year PFS and OS were significantly lower in the MYC(+) DLBCL patients than those in the MYC(-) DLBCL patients, with rates of 18% vs 42% (P = .0322), and of 29% vs 62% (P = .0113), respectively. Type of treatment, R-DHAP or R-ICE, had no impact on survivals, with 4-year PFS rates of 17% vs 19% and 4-year OS rates of 26% vs 31%. In conclusion, MYC rearrangement is an early event in DLBCL. MYC(+) DLBCL patients have a significant inferior prognosis than MYC(-) DLBCL patients. Their outcome was not influenced by the proposed salvage therapy.
Back Cover: Efficient Luminescence from Fluorene‐ and Spirobifluorene‐Based Lanthanide Complexes upon Near‐Visible Irradiation (Chem. Eur. J. 16/2014) (2014)

The development of luminescent lanthanide complexes with improved brightness and stability holds great promise for the production of new multifunctional probes for biochemical and biomedical purposes. From the practical point of view, the shift of the excitation wavelength from medium UV towards the visible region is fundamental to make the luminophores optically compatible with low-cost polymeric materials. In addition to these features, the fluorene- and spirobifluorene-based europium antenna complexes presented herein exhibit high color purity and water solubility, and are clearly detectable in very diluted solutions (ca. 10 pM). For more details, see the Full Paper on page 4598 ff. by L. Armelao and S. Quici et al.
Overdose (2016)

Abstract Acetaminophen overdose is the most common medication poisoning reported to US poison control centers and is the most common cause of acute liver failure in the western world. Acetaminophen is a component of several over-the-counter and prescription medications. Overdose can be intentional or accidental, and it should be considered in the differential diagnosis of markedly elevated liver enzymes. Management includes early recognition, supportive management, removal of unabsorbed medication, prompt antidote administration, and referral to a liver transplant center.
End to End Trainable Active Contours via Differentiable Rendering (2019)

We present an image segmentation method that iteratively evolves a polygon. At each iteration, the vertices of the polygon are displaced based on the local value of a 2D shift map that is inferred from the input image via an encoder-decoder architecture. The main training loss that is used is the difference between the polygon shape and the ground truth segmentation mask. The network employs a neural renderer to create the polygon from its vertices, making the process fully differentiable. We demonstrate that our method outperforms the state of the art segmentation networks and deep active contour solutions in a variety of benchmarks, including medical imaging and aerial images. Our code is available at https://github.com/shirgur/ACDRNet.
Comparison of the Response of Human Embryonic Stem Cells and Their Differentiated Progenies to Oxidative Stress (2009)

Undifferentiated hESC are intrinsically more resistant to oxidative stress compared to their spontaneously differentiated fibroblastic progenies.
New dihydrochalcone glycosides fromLithocarpus litseifoliusand the phenomenon of C–H→C–D exchange observed in NMR spectra of phenolic components (2009)

Two new dihydrochalcone glycosides named 6''-O-acetyltrilobatin (1) and 3''-O-acetylphloridzin (2) as well as four known compounds were isolated from the leaves of Lithocarpus litseifolius (Hance) Chun (family Fagaceae). Their structures were elucidated on the basis of spectroscopic analyses. The phenomena of C-H --> C-D exchange were observed in NMR spectra of the isolated phenolic components when measured in deuterated methanol.
In vivo detection of changes in cutaneous carotenoids after chemotherapy using shifted excitation resonance Raman difference and fluorescence spectroscopy (2020)

The SERRDS based noninvasive detection can be used as an indirect quantitative assessment of fluorescent chemotherapeutics. The lower carotenoid SERRDS intensities at T<sub>base</sub> might be due to cancerous diseases and co-medication.
ChemInform Abstract: OZONATION IN ALKALOID CHEMISTRY: A MILD AND SELECTIVE CONVERSION OF VINCADIFFORMINE INTO VINCAMINE (1982)

Abstract Die Ozonolyse von Vincadifformin (I) ergibt in stereoselektiver Weise den Hydroxycarbonsäureester (II).
Migraine — Treatment of Acute Attack (1985)

The treatment of an acute attack of classical or common migraine is sleep, an antinauseant such as metoclopramide, an analgesic, either aspirin or paracetamol, and in some patients 1 or 2 mg of ergotamine tartrate. Treatment should be given as early in the attack as possible and all drugs should, if possible, be given in a soluble or effervescent form. When vomiting occurs early in the attack, treatment is best given by suppository, inhalation or intramuscular injection. Ergotamine tartrate is only necessary in about one third of attacks and when used is best given by suppository or inhalation. Doses of ergotamine tartrate higher than 2 mg per attack or 6 mgs per week may cause toxic symptoms as may the abuse of analgesics.
Engineering Mechanics for Successive States in Canine Left Ventricular Myocardium (1973)

The relations between end-diastolic ( D ) and end-systolic (S) cavitary volumes ( V c ), wall volumes ( V 10 ), and cavitary dimensions have been studied in the canine and human left ventricle. However, the models selected for left ventricular myocardium do not represent the real heart adequately for a fiber-by-fiber analysis of fiber orientation and sarcomere length during successive states of the ejection cycle. In this study, the endocardial and epicardial surfaces were postulated to be a nested set of truncated ellipsoidal shells of revolution where wall volumes were preserved from D to S. Shell dimensions on the semiminor and semimajor axes, R and Z , respectively, were related to V c and V w by two representations: confocal and nonconfocal. If the focal length C = ) 1/2 and C is the same for each shell, then the shells are confocal, otherwise they are nonconfocal. From measured V c , V w , and epicardial Z in D , shell dimensions were calculated for states D and S, using both confocal and nonconfocal representations, and compared with the measured dimensions. When no empirical corrections were made, the calculated endocardial R in S underestimated the measured R in S by 12%; moreover, the calculated epicardial R in S overestimated the measured R in S by 4%. Endocardial and epicardial C measured 3.73 ± 0.33 (SE) cm and 3.79 ±0.34 cm, respectively, in D and 3.77±0.11 cm and 3.71 ±0.10 cm, respectively, in S.
An Analytical Investigation of DC/DC Power Electronic Converters With Constant Power Loads in Vehicular Power Systems (2008)

Stability of multi-converter power systems, which exist in advanced more electric vehicles, is of great importance. The stability issue is investigated in this paper, and design considerations and limitations of the methods that stabilize the open-loop converters are presented. By stabilizing the open-loop converter, it is shown that the feedback loop design is usually translated into a conventional feedback design task. The behavior of the unstable converter is also discussed, and a method for decreasing the amplitude of the output voltage oscillations is proposed. The model of a tightly regulated practical converter is presented. This model is used to decide how much damping should be added to make the feeder converter stable. Furthermore, because we have this information about the load converter, the feeder converter can be redesigned so that it does not see the load converter as a constant power load.
ChemInform Abstract: Reactivity of Ruthenium Carbonyls on Metal Oxide Surfaces. Effects of the Surface Acid‐Base Chemistry. (1988)

Abstract By means of IR and electronic spectroscopy as well as electron microscopy the reactivity of H 4 Ru 4 (CO) 12 clusters supported on the metal oxides SiO 2 , TiO 2 , γ‐Al 2 O 3 and MgO is investigated.
Cyclopropyl Thioethers, New Inputs for Palladium Catalyzed Ring Opening of Cyclopropanes (2019)

We present herein a new palladium-catalyzed ring opening of cyclopropane-substituted thioethers. The study involves an intramolecular trapping of an intermediate aryl palladium to afford thiochromene derivatives. In contrast to the analogous cyclopropylamines which led to efficient ring opening using triphenylphosphine as ligand for palladium, good yields for cyclopropyl thioethers required the use of bulkier electron-donating phosphines, such as tri-tert-butylphosphine.
An Agrobacterium-mediated system for gene transfer in Pinus patula (2007)

A pioneer study investigating the feasibility of using Agrobacterium-mediated gene transfer was undertaken in Pinus patula, the most important softwood species in South African forestry. This was achieved via the introduction of pAHC25 under the control of the ubiquitin promoter. A variety of target tissues were tested including: mature zygotic embryos, mature somatic embryos and embryonal suspensor masses (ESM). Expression of positive histochemical GUS activity in transformed material was confirmed by polymerase chain reaction (PCR) analysis. Results indicated that Pinus patula tissue was amenable to transformation. Use of the ESM tissue type, together with inclusion of l-proline in the medium, provided the most suitable transformation system.
Financial Brownian Particle in the Layered Order-Book Fluid and Fluctuation-Dissipation Relations (2014)

We introduce a novel description of the dynamics of the order book of financial markets as that of an effective colloidal Brownian particle embedded in fluid particles. The analysis of comprehensive market data enables us to identify all motions of the fluid particles. Correlations between the motions of the Brownian particle and its surrounding fluid particles reflect specific layering interactions; in the inner layer the correlation is strong and with short memory, while in the outer layer it is weaker and with long memory. By interpreting and estimating the contribution from the outer layer as a drag resistance, we demonstrate the validity of the fluctuation-dissipation relation in this nonmaterial Brownian motion process.
MRI-Based Automated Computer Classification of Probable AD Versus Normal Controls (2008)

Automated computer classification (ACC) techniques are needed to facilitate physician's diagnosis of complex diseases in individual patients. We provide an example of ACC using computational techniques within the context of cross-sectional analysis of magnetic resonance images (MRI) in neurodegenerative diseases, namely Alzheimer's dementia (AD). In this paper, the accuracy of our ACC methodology is assessed when presented with real life, imperfect data, i.e., cohorts of MRI with varying acquisition parameters and imaging quality. The comparative methodology uses the Jacobian determinants derived from dense deformation fields and scaled grey-level intensity from a selected volume of interest centered on the medial temporal lobe. The ACC performance is assessed in a series of leave-one-out experiments aimed at separating 75 probable AD and 75 age-matched normal controls. The resulting accuracy is 92% using a support vector machine classifier based on least squares optimization. Finally, it is shown in the Appendix that determinants and scaled grey-level intensity are appreciably more robust to varying parameters in validation studies using simulated data, when compared to raw intensities or grey/white matter volumes. The ability of cross-sectional MRI at detecting probable AD with high accuracy could have profound implications in the management of suspected AD candidates.
An Animal Model for Norrie Disease (ND): Gene Targeting of the Mouse Nd Gene (1996)

In order to elucidate the cellular and molecular processes which are involved in Norrie disease (ND), we have used gene targeting technology to generate ND mutant mice. The murine homologue of the ND gene was cloned and shown to encode a polypeptide that shares 94% of the amino acid sequence with its human counterpart. RNA in situ hybridization revealed expression in retina, brain and the olfactory bulb and epithelium of 2 week old mice. Hemizygous mice carrying a replacement mutation in exon 2 of the ND gene developed retrolental structures in the vitreous body and showed an overall disorganization of the retinal ganglion cell layer. The outer plexiform layer disappears occasionally, resulting in a juxtaposed inner and outer nuclear layer. At the same regions, the outer segments of the photoreceptor cell layer are no longer present. These ocular findings are consistent with observations in ND patients and the generated mouse line provides a faithful model for study of early pathogenic events in this severe X-linked recessive neurological disorder.
LONG‐TERM OUTCOME OF PATIENTS WITH RELAPSED/REFRACTORY B‐CELL NON‐ HODGKIN LYMPHOMA TREATED WITH BISPECIFIC ANTIBODY BLINATUMOMAB IN A PHASE I TRIAL (2019)

Introduction: Treatment of relapsed/refractory (rr) Non-Hodgkin's lymphoma of B-cell type (B-NHL) is still challenging and new and more effective therapies are urgently warranted. Blinatumomab, a first-in-class bispecific T-cell engager (BiTE®) antibody construct, engages CD3+ cytotoxic T cells, resulting in T-cell expansion and lysis of CD19+ B cells. In a prior phase I study, blinatumomab treatment resulted in an overall response rate (ORR) of 69% and 55% in diffuse large B-cell lymphoma (DLBCL), respectively for patients treated at MTD 60 μg/m²/d. The clinically most relevant side effects are neurological symptoms and cytokine release syndrome. Based on this study we here present first single-center, long-term follow-up data on 38 patients with r/r B-NHL after treatment with blinatumomab. Methods: Patients with rr B-NHL who participated in the phase I MT103-104 trial (NCT00274742) and were treated with blinatumomab at the trial site Wuerzburg were eligible for long-term follow-up analysis. Kaplan-Meier estimates for progression free survival (PFS) probability were calculated from first infusion to relapse or death. Patients without an event were censored at last follow-up. This study was conducted in accordance with the Declaration of Helsinki. Conclusion: Here we provide first evidence that blinatumomab has the potential to induce sustained long-term remissions in patients with rr B-NHL. Prerequisite for durable remission is treatment at the effective dose of 60 μg/m²/day. Treatment with Blinatumomab in rr B-NHL is efficient. Keywords: B-cell lymphoma; CD19; CD3.
Modeling of Asymmetrical Grid Faults for P-HIL Accuracy and Stability Analysis in LVRT Tests (2023)

&lt;p&gt;The energy systems are evolving toward the comprehensive and massive integration of power electronics-based technologies, such as photovoltaic, wind turbines, and electric vehicles. All these emerging and promising power converters technologies must be tested to comply with the grid codes, especially during severe grid fault events, before their commercialization. Low-Voltage Ride-Through (LVRT) field tests are usually conducted to prove the ability of the converter to ride through faults. These field tests are expensive and require bulky equipment, while Power-Hardware-in-the-Loop (P-HIL) offers a more cost-effective and flexible alternative. However, the P-HIL must be stable and accurate to get reliable results. The accuracy of a P-HIL test is directly influenced by its interface algorithm. This paper proposes a frequency domain approach, based on the concept of singular values in Multi-Input Multi-Output systems, to study the P-HIL accuracy and stability in grid connected converter testing under asymmetrical line-to-line fault conditions. Accuracy and stability analysis have been performed analytically and validated by Matlab/Simulink simulations and by experimental P-HIL tests. This paper demonstrates that correct fault modeling leads to correct assessment of the reactive power injected under faults and of avoiding resonances.&lt;/p&gt;
Imaging and reconstruction of positive streamer discharge tree structures (2023)

Raw experimentel data (stereoscopic and stroboscopic images) Matlab scripts for processing the images Processed image data in .mat file Matlab scripts for reconstructing streamer discharge trees from the .mat file and showing the relevant analysis plots
The effect of vitamin A deficiency on the cholesterol levels of the plasma and liver of the rat (1955)

Research Article| November 01 1955 The effect of vitamin A deficiency on the cholesterol levels of the plasma and liver of the rat B. Green; B. Green 1Department of Biochemistry, University of Liverpool Search for other works by this author on: This Site PubMed Google Scholar J. S. Lowe; J. S. Lowe 1Department of Biochemistry, University of Liverpool Search for other works by this author on: This Site PubMed Google Scholar R. A. Morton R. A. Morton 1Department of Biochemistry, University of Liverpool Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1955) 61 (3): 447–453. https://doi.org/10.1042/bj0610447 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation B. Green, J. S. Lowe, R. A. Morton; The effect of vitamin A deficiency on the cholesterol levels of the plasma and liver of the rat. Biochem J 1 November 1955; 61 (3): 447–453. doi: https://doi.org/10.1042/bj0610447 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1955 CAMBRIDGE UNIVERSITY PRESS1955 Article PDF first page preview Close Modal You do not currently have access to this content.