gebhart/patrepeval huggingface dataset:
Phase alignment in Ag-clad Bi-Sr-Ca-Cu-O (2:2:1:2) wires (1990)

Powder-in-tube wires that contained Bi, Sr, Ca, and Cu in a 2:2:1:2 mole ratio were drawn then rolled flat before processing. The superconducting phase was aligned with its c axis perpendicular to the wide plane of the wire by sintering the wires just below the melting point and by melt processing. Melt processing with slow cooling of the melt yielded the most alignment. Gravity did not influence alignment during melt processing.
Data from Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8<sup>+</sup> T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;OX40 agonist–based combinations are emerging as a novel avenue to improve the effectiveness of cancer immunotherapy. To better guide its clinical development, we characterized the role of the OX40 pathway in tumor-reactive immune cells. We also evaluated combining OX40 agonists with targeted therapy to combat resistance to cancer immunotherapy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We utilized patient-derived tumor-infiltrating lymphocytes (TILs) and multiple preclinical models to determine the direct effect of anti-OX40 agonistic antibodies on tumor-reactive CD8&lt;sup&gt;+&lt;/sup&gt; T cells. We also evaluated the antitumor activity of an anti-OX40 antibody plus PI3Kβ inhibition in a transgenic murine melanoma model (&lt;i&gt;Braf&lt;/i&gt; mutant, PTEN null), which spontaneously develops immunotherapy-resistant melanomas.&lt;/p&gt;Results:&lt;p&gt;We observed elevated expression of OX40 in tumor-reactive CD8&lt;sup&gt;+&lt;/sup&gt; TILs upon encountering tumors; activation of OX40 signaling enhanced their cytotoxic function. OX40 agonist antibody improved the antitumor activity of CD8&lt;sup&gt;+&lt;/sup&gt; T cells and the generation of tumor-specific T-cell memory &lt;i&gt;in vivo&lt;/i&gt;. Furthermore, combining anti-OX40 with GSK2636771, a PI3Kβ-selective inhibitor, delayed tumor growth and extended the survival of mice with PTEN-null melanomas. This combination treatment did not increase the number of TILs, but it instead significantly enhanced proliferation of CD8&lt;sup&gt;+&lt;/sup&gt; TILs and elevated the serum levels of CCL4, CXCL10, and IFNγ, which are mainly produced by memory and/or effector T cells.&lt;/p&gt;Conclusions:&lt;p&gt;These results highlight a critical role of OX40 activation in potentiating the effector function of tumor-reactive CD8&lt;sup&gt;+&lt;/sup&gt; T cells and suggest further evaluation of OX40 agonist–based combinations in patients with immune-resistant tumors.&lt;/p&gt;&lt;/div&gt;
ChemInform Abstract: The Design, Synthesis, and Physical Chemical Properties of Novel Human Vasopressin V2‐Receptor Antagonists Optimized for Parenteral Delivery. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mean Coronary Cross‐Sectional Area as a Measure of Arterial Remodeling Using Noncontrast CT Imaging in Persons With HIV (2022)

Background Persons with HIV have a higher prevalence of coronary artery disease compared with their HIV-negative counterparts. Earlier identification of subclinical atherosclerosis may provide a greater opportunity for cardiovascular disease risk reduction. We investigated coronary cross-sectional area (CorCSA) by noncontrasted computed tomography imaging as a noninvasive measure of arterial remodeling among virally suppressed persons with HIV. Methods and Results We assessed 105 persons with HIV with a spectrum of cardiometabolic health. All participants underwent computed tomography imaging to assess the mean corCSA of the proximal left anterior descending artery and 28 participants underwent additional coronary computed tomography angiography. Partial Spearman rank correlations adjusted for cardiovascular disease risk factors were used to assess relationships of corCSA with anthropometric measurements, HIV-related factors, and plasma cytokines. Mean corCSA measured by noncontrast computed tomography and coronary computed tomography angiography were strongly correlated (ρ=0.91, <i>P</i><0.0001). Higher mean corCSA was present in those with coronary artery calcium (<i>P</i>=0.005) and it correlated with participants' atherosclerotic cardiovascular disease risk score (ρ=0.35, <i>P</i>=0.01). After adjusting for established cardiovascular disease risk factors, we observed an inverse relationship between corCSA and CD4<sup>+</sup> T-cell count (ρ=-0.2, <i>P</i>=0.047). Removal of age from the model strengthened the relationships between corCSA and antiretroviral therapy duration (from ρ=0.19, <i>P</i>=0.08 to ρ=0.3, <i>P</i>=0.01). CorCSA was also inversely correlated with plasma IL-10 (ρ=-0.25, <i>P</i>=0.03) but had no relationship with IL-6 (ρ=0.11, <i>P</i>=0.4) or IL-1β (ρ=0.08, <i>P</i>=0.5). Conclusions Positive coronary arterial remodeling, an imaging marker of subclinical atherosclerosis, is associated with a lower CD4 T-cell count, lower circulating IL-10, and possibly a longer antiretroviral therapy duration in persons with HIV. Registration Clinicaltrials.gov; Unique identifier: NCT04451980.
Antibody to hepatitis B core antigen is associated with the development of hepatocellular carcinoma in hepatitis C virus-infected persons: A 12-year prospective study (2006)

Several studies have reported that antibody to hepatitis B core antigen (anti-HBc) positivity may influence the development of hepatocellular carcinoma (HCC) in chronic hepatitis C patients, but the evidence is still not conclusive. In this study, we examined whether the presence of anti-HBc positive was associated with the development of HCC in hepatitis C virus (HCV)-infected subjects among the residents in an HCV hyperepidemic area who were followed up for 12 years. In an HCV hyperendemic area (positive rate of anti-HCV: 23.4%), 509 residents were examined by health screening in 1990. After 12 years of follow-up, we evaluated the risk factors for HCC. The incidence of HCC was compared between anti-HBc positive and anti-HBc negative subjects after 12 years of prospective observation. Univariate and multivariate analyses were conducted to determine risk factors for the development of HCC. The incidence of HCC was significantly higher in the anti-HBc positive group (13 subjects) than in the anti-HBc negative group (0 subjects) (P=0.012). Multivariate analysis identified positivity for anti-HBc and HCV RNA, history of icterus, and female gender as independent determinants of the development of HCC. Our findings provide clear evidence in a prospective study that presence of anti-HBc, that is, past hepatitis B virus (HBV) infection, is a risk factor for the development of HCC in HCV-infected people.
Transperineal Prostate Intervention: Robot for Fully Automated MR Imaging—System Description and Proof of Principle in a Canine Model (2008)

The study was approved by the animal care and use committee. The purpose of the study was to prospectively establish proof of principle in vivo in canines for a magnetic resonance (MR) imaging-compatible robotic system designed for image-guided prostatic needle intervention. The entire robot is built with nonmagnetic and dielectric materials and in its current configuration is designed to perform fully automated brachytherapy seed placement within a closed MR imager. With a 3.0-T imager, in four dogs the median error for MR imaging-guided needle positioning and seed positioning was 2.02 mm (range, 0.86-3.18 mm) and 2.50 mm (range, 1.45-10.54 mm), respectively. The robotic system is capable of accurate MR imaging-guided prostatic needle intervention within a standard MR imager in vivo in a canine model.
Polar Metabolites of the Tropical Green SeaweedCaulerpa taxifolia Which Is Spreading in the Mediterranean Sea: Glycoglycerolipids and Stable Enols (α\=Keto Esters) (1998)

Examination of the polar components of the green seaweed Caulerpa taxifolia (Vahl) C. Agardh, which is heavily spreading in the northeastern Mediterranean, led to two families of compounds. The new (2R)-3-O-β-D-galactopyranosyl-1-O-[(7Z,10Z,13Z)-hexadeca-7,10,13-trienoyl]-2-O-[(9Z,12Z,15Z)-octadeca-1,12,15-trienoyl]-sn-glycerol (2) was isolated in low abundance, like the analogues 1 and 3 already known from freshwater cyanobacteria. The acyl positions in 1 – 3 were determined by enzymatic methods and the absolute configuration from the O-galactosylglycerol obtained upon alcaline methanolysis. More abundant were the (4-hydroxyphenyl)- and (3,4-dihydroxyphenyl)pyruvic acid methyl esters, occurring in the enol (Z) forms 13a and 14a accompanied by very minor (E) forms 13b and 14b. The latter became predominant on UV irradiation of 13a or 14a, allowing the determination of the C=C configuration of these isolatable, stable enols from 1H,13C NMR couplings (larger H−C(3)/C(1) coupling constant in the (E) than in the (Z) isomer). Contrary to literature implications, the O-galactosylglycerolipids 1 – 3 lack any cholinergic or histaminergic activity; similarly, enols (= α-keto esters) 13 and 14 or terpenoids of this seaweed were also devoid of such biological activities (see Table).
Cladophora glomerata enriched by biosorption with Mn(II) ions alleviates lipopolysaccharide‐induced osteomyelitis‐like model in MC3T3‐E1, and 4B12 osteoclastogenesis (2020)

Chronic osteomyelitis, a bone infectious disease, is characterized by dysregulation of bone homeostasis, which results in excessive bone resorption. Lipopolysaccharide (LPS) which is a gram-negative endotoxin was shown to inhibit osteoblast differentiation and to induce apoptosis and osteoclasts formation in vitro. While effective therapy against bacteria-induced bone destruction is quite limited, the investigation of potential drugs that restore down-regulated osteoblast function remains a major goal in the prevention of bone destruction in infective bone diseases. This investigation aimed to rescue LPS-induced MC3T3-E1 pre-osteoblastic cell line using the methanolic extract of Cladophora glomerata enriched with Mn(II) ions by biosorption. LPS-induced MC3T3-E1 cultures supplemented with C. glomerata methanolic extract were tested for expression of the main genes and microRNAs involved in the osteogenesis pathway using RT-PCR. Moreover, osteoclastogenesis of 4B12 cells was also investigated by tartrate-resistant acid phosphatase (TRAP) assay. Treatment with algal extract significantly restored LPS-suppressed bone mineralization and the mRNA expression levels of osteoblast-specific genes such as runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN), osteopontin (OPN), miR-27a and miR-29b. The extract also inhibited osteoblast apoptosis, significantly restored the down-regulated expression of Bcl-2, and decreased the loss of MMP and reactive oxygen spices (ROS) production in MC3T3-E1 cells induced by LPS. Furthermore, pre-treatment with algal extract strongly decreased the activation of osteoclast in MC3T3-E1-4B12 coculture system stimulated by LPS. Our findings suggest that C. glomerata enriched with Mn(II) ions may be a potential raw material for the development of drug for preventing abnormal bone loss induced by LPS in bacteria-induced bone osteomyelitis.
Fine-Grained Multi-label Sexism Classification Using a Semi-Supervised Multi-level Neural Approach (2021)

Abstract Sexism, a permeate form of oppression, causes profound suffering through various manifestations. Given the increasing number of experiences of sexism shared online, categorizing these recollections automatically can support the battle against sexism, since it can promote successful evaluations by gender studies researchers and government representatives engaged in policy making. In this paper, we examine the fine-grained, multi-label classification of accounts (reports) of sexism. To the best of our knowledge, we consider substantially more categories of sexism than any related prior work through our 23-class problem formulation. Moreover, we present the first semi-supervised work for the multi-label classification of accounts describing any type(s) of sexism. We devise self-training-based techniques tailor-made for the multi-label nature of the problem to utilize unlabeled samples for augmenting the labeled set. We identify high textual diversity with respect to the existing labeled set as a desirable quality for candidate unlabeled instances and develop methods for incorporating it into our approach. We also explore ways of infusing class imbalance alleviation for multi-label classification into our semi-supervised learning, independently and in conjunction with the method involving diversity. In addition to data augmentation methods, we develop a neural model which combines biLSTM and attention with a domain-adapted BERT model in an end-to-end trainable manner. Further, we formulate a multi-level training approach in which models are sequentially trained using categories of sexism of different levels of granularity. Moreover, we devise a loss function that exploits any label confidence scores associated with the data. Several proposed methods outperform various baselines on a recently released dataset for multi-label sexism categorization across several standard metrics.
CONSOLIDATION CHARACTERISTIC AND STRENGTH ESTIMATION OF MEDIUM HIGH-PRESSURE DEHYDRATION DREDGED SOIL BLOCK (2021)

著者らは, 高圧脱水固化処理装置によって, 高含水比の浚渫土砂を高強度ブロックとして有効利用する技術開発を行っている. 本論文では, 放射状排水理論に着目してブロック作製時の圧密特性と強度特性を調査した. さらに, 放射状排水理論を用いた強度推定を行い, 実測値との比較によってこの推定方法の妥当性を評価した. 得られた結論をまとめると以下のようになる. (1) 固化処理土ブロック作製時の圧密時間は, 放射状排水理論を適応させた脱水棒を用いることで用いない条件の45時間から6時間となり約39時間短縮する事ができた. (2) 脱水棒を用いて作製した高圧脱水固化処理土ブロックの28日強度は10.5MPa となった. (3) 放射状排水理論を用いた強度推定の実測値との誤差は, 1.5MPa以内となり, 高い精度での強度推定が可能となった.
Significant Life Experiences and Formative Influences on the Development of Adults’ Environmental Awareness in the UK, Australia and Canada (1999)

Summary Environmental educators in Australia (n = 82), and Canada (n = 48) wrote autobiographical statements describing the formative influences and significant life experiences (SLE) which led to their concern for the environment. Content analysis identified the influences/experiences mentioned most often, both as single factors, e.g. ‘close family’, and as groups of logically related factors, e.g. ‘people’, a group composed of the factors ‘close family’, ‘older friends'’, ‘friends'’, and ‘having children’. The final lists of single factors were similar but not identical in the two countries, and both differed slightly from the list already derived from a sample of environmental educators in the UK (n = 233). Here we present the single and grouped factors named most often in Australia, then do the same for Canada, and then compare the principal factors in all three nations.
A system for quantitatively assessing certain performance parameters of gamma camera systems from reflective print and film transparency final images (1986)

Past efforts at routine evaluation of gamma camera systems performance, using final product images, primarily resulted in qualitative assessments. This paper describes a system for quantitatively determining certain performance parameters of gamma camera systems using paper-backed print and transparent film test images of the same type used for viewing by the nuclear medicine physician. By use of appropriate transmission and line source phantoms, the gamma camera system's spatial resolution, distortion, and flood field uniformity as a function of position in the image field, are determined using a semiautomated image scanning and data reduction system. This system consists of a high-resolution scanning microdensitometer/reflectometer, interfaced to a computer, along with necessary programs to locate bar and line grid intersection points in the image. Also included are algorithms for calculating the various image parameters desired. This system may provide an analytical method for quantitatively assessing certain performance parameters of gamma camera systems, using the final-product images from the cameras.
Reduction of Acetals with TiCl4–LiAlH4 (1978)

Abstract The reduction of dialkyl acetals derived from aromatic aldehydes and ketones with TiCl4–LiAlH4 in THF or diethyl ether at room temperature afforded the coupling products, pinacol ethers or olefins, in high yields. On the other hand, when acetals derived from aliphatic aldehydes and ketones were treated with TiCl4–LiAlH4 in diethyl ether, the reductive dealkoxylation took place and the corresponding ethers were isolated in good yields. As to the reaction mechanism we propose that Ti(II) is the reactive species in reductive coupling reaction of acetals derived from aromatic aldehydes and ketones, and that Ti(0)–H2AlCl complex may be the reactive species in reductive dealkoxylation of acetals derived frcm aliphatic aldehydes and ketones.
Wavefront Measurement in Ophthalmology 9 Aberrometry Through the Eyes of an Engineer (2013)

Wavefront sensing or aberration measurement in the eye is a key problem in refractive surgery and vision correction with laser. The accuracy of these measurements is critical for the outcome of the surgery. Practically all clinical methods use laser as a source of light. To better understand the background, we analyze the pre-laser techniques developed over centuries. They allowed new discoveries of the nature of the optical system of the eye, and many served as prototypes for laser-based wavefront sensing technologies. Hartmann’s test was strengthened by Platt’s lenslet matrix and the CCD two-dimensional
An Instrument for the Determination of Contact Making and Breaking Time (1943)

This paper describes an electronic instrument for the measurement of the arcing time of a contact closing or opening a circuit. This measurement is accomplished by permitting a current of constant value to flow into a capacitor during the time that an arc exists across the contacts under observation; the charge accumulated on the capacitor is therefore a measure of the arcing time. The instrument also contains electronic means of measuring the charge on the capacitor, by determining the voltage existing across it at the end of the measurement. The circuit serving this purpose is a Wheatstone bridge with a tube in one arm, to whose grid the capacitor is connected, and a microammeter in the diagonal which indicates directly the amount of unbalance produced by the capacitor voltage. The application of the instrument to the investigation of a three-pole contactor is described.
A Literature-Based Knowledge Graph Embedding Method for Identifying Drug Repurposing Opportunities in Rare Diseases (2019)

Millions of Americans are affected by rare diseases, many of which have poor survival rates. However, the small market size of individual rare diseases, combined with the time and capital requirements of pharmaceutical R&D, have hindered the development of new drugs for these cases. A promising alternative is drug repurposing, whereby existing FDA-approved drugs might be used to treat diseases different from their original indications. In order to generate drug repurposing hypotheses in a systematic and comprehensive fashion, it is essential to integrate information from across the literature of pharmacology, genetics, and pathology. To this end, we leverage a newly developed knowledge graph, the Global Network of Biomedical Relationships (GNBR). GNBR is a large, heterogeneous knowledge graph comprising drug, disease, and gene (or protein) entities linked by a small set of semantic themes derived from the abstracts of biomedical literature. We apply a knowledge graph embedding method that explicitly models the uncertainty associated with literature-derived relationships and uses link prediction to generate drug repurposing hypotheses. This approach achieves high performance on a gold-standard test set of known drug indications (AUROC = 0.89) and is capable of generating novel repurposing hypotheses, which we independently validate using external literature sources and protein interaction networks. Finally, we demonstrate the ability of our model to produce explanations of its predictions.
Sample collection of virulent and non-virulent B. anthracis and Y. pestis for bioforensics analysis (2009)

Validated sample collection methods are needed for recovery of microbial evidence in the event of accidental or intentional release of biological agents into the environment. To address this need, we evaluated the sample recovery efficiencies of two collection methods -- swabs and wipes -- for both non-virulent and virulent strains of B. anthracis and Y. pestis from four types of non-porous surfaces: two hydrophilic surfaces, stainless steel and glass, and two hydrophobic surfaces, vinyl and plastic. Sample recovery was quantified using Real-time qPCR to assay for intact DNA signatures. We found no consistent difference in collection efficiency between swabs or wipes. Furthermore, collection efficiency was more surface-dependent for virulent strains than non-virulent strains. For the two non-virulent strains, B. anthracis Sterne and Y. pestis A1122, collection efficiency was approximately 100% and 1 %, respectively, from all four surfaces. In contrast, recovery of B. anthracis Ames spores and Y. pestis C092 from vinyl and plastic was generally lower compared to collection from glass or stainless steel, suggesting that surface hydrophobicity may playa role in the strength of pathogen adhesion. The surface-dependent collection efficiencies observed with the virulent strains may arise from strain-specific expression of capsular material or other cell surface receptors that alter cell adhesion to specific surfaces. These findings contribute to validation of standard bioforensics procedures and emphasize the importance of specific strain and surface interactions in pathogen detection.
Photophysics of π-Conjugated Polymers That Incorporate Metal to Ligand Charge Transfer Chromophores (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTPhotophysics of π-Conjugated Polymers That Incorporate Metal to Ligand Charge Transfer ChromophoresKevin D. Ley, C. Ed Whittle, Michael D. Bartberger, and Kirk S. SchanzeView Author Information Department of Chemistry, University of Florida Gainesville, Florida 32611-7200 Cite this: J. Am. Chem. Soc. 1997, 119, 14, 3423–3424Publication Date (Web):April 9, 1997Publication History Received18 September 1996Revised10 February 1997Published online9 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/ja963278thttps://doi.org/10.1021/ja963278trapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views744Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Absorption,Energy transfer,Excited states,Metal to ligand charge transfer,Polymers Get e-Alerts