gebhart/patrepeval huggingface dataset:
Polymer−Graphite Nanocomposites:  Effective Dispersion and Major Property Enhancement via Solid-State Shear Pulverization (2008)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPolymer−Graphite Nanocomposites: Effective Dispersion and Major Property Enhancement via Solid-State Shear PulverizationKatsuyuki Wakabayashi, Cynthia Pierre, Dmitriy A. Dikin, Rodney S. Ruoff, Thillaiyan Ramanathan, L. Catherine Brinson, and John M. TorkelsonView Author Information Department of Chemical and Biological Engineering, Department of Materials Science and Engineering, and Department of Mechanical Engineering, Northwestern University, Evanston, Illinois 60208 Cite this: Macromolecules 2008, 41, 6, 1905–1908Publication Date (Web):February 29, 2008Publication History Received28 July 2007Revised2 November 2007Published online29 February 2008Published inissue 1 March 2008https://pubs.acs.org/doi/10.1021/ma071687bhttps://doi.org/10.1021/ma071687brapid-communicationACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views3915Altmetric-Citations264LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anode materials,Carbon,Nanocomposites,Nanoparticles,Physical and chemical processes Get e-Alerts
IκB Kinase-Independent IκBα Degradation Pathway: Functional NF-κB Activity and Implications for Cancer Therapy (2003)

Antiapoptotic activity of NF-kappaB in tumors contributes to acquisition of resistance to chemotherapy. Degradation of IkappaB is a seminal step in activation of NF-kappaB. The IkappaB kinases, IKK1 and IKK2, have been implicated in both IkappaB degradation and subsequent modifications of NFkappaB. Using mouse embryo fibroblasts (MEFs) devoid of both IKK1 and IKK2 genes (IKK1/2(-/-)), we document a novel IkappaB degradation mechanism. We show that this degradation induced by a chemotherapeutic agent, doxorubicin (DoxR), does not require the classical serine 32 and 36 phosphorylation or the PEST domain of IkappaBalpha. Degradation of IkappaBalpha is partially blocked by phosphatidylinositol 3-kinase inhibitor LY294002 and is mediated by the proteasome. Free NF-kappaB generated by DoxR-induced IkappaB degradation in IKK1/2(-/-) cells is able to activate chromatin based NF-kappaB reporter gene and expression of the endogenous target gene, IkappaBalpha. These results also imply that modification of NF-kappaB by IKK1 or IKK2 either prior or subsequent to its release from IkappaB is not essential for NF-kappaB-mediated gene expression at least in response to DNA damage. In addition, DoxR-induced cell death in IKK1/2(-/-) MEFs is enhanced by simultaneous inhibition of NF-kappaB activation by blocking the proteasome activity. These results reveal an additional pathway of activating NF-kappaB during the course of anticancer therapy and provide a mechanistic basis for the observation that proteasome inhibitors could be used as adjuvants in chemotherapy.
Isolation of a Chinese Hamster Ovary Cell Clone Possessing Decreased µ-Calpain Content and a Reduced Proliferative Growth Rate (1996)

A Chinese hamster ovary cell line (CHOp) was cultured in the presence of benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone (ZLLY-CHN2), to select for resistance to this cell-permeant calpain inhibitor. A clone isolated after several courses of exposure (SHI cells) demonstrated decreased sensitivity to ZLLY-CHN2 toxicity and a decreased growth rate. SHI cells also possessed less mu-calpain isozyme relative to CHOp cells, as determined by activity measurement or by protein immunoblotting. Activities of m-calpain, calpastatin, cathepsin B, cathepsin L, and glycogen phosphorylase were not altered. SHI mu-calpain was partially purified by sequential chromatography on Bio-Gel A-1.5m and DEAE-Sepharose. Its chromatographic behavior in either system was the same as for CHOp mu-calpain. Further studies with the partially purified SHI and CHOp mu-calpain fractions failed to distinguish any difference in Ca2+ requirement or in sensitivity to inhibition by calpastatin or ZLLY-CHN2 for these enzymes. These experiments suggest that SHI cells underproduce a form of mu-calpain which is very similar to, if not identical with, CHOp mu-calpain. SHI cells displayed a population doubling time of 29 h compared with 19 h for CHOp cells. The decreased growth rate of SHI cells was the result of a prolonged G1 phase. Introduction of purified human mu-calpain into SHI cells by electroporation transiently restored the growth rate and also increased toxicity associated with exposure to ZLLY-CHN2. SHI cells should be a valuable model in further studies to delineate the function of mu-calpain in cell proliferative growth.
Variation in Characteristics of Abraded Roadway Particles as a Function of Particle Size: Implications for Water Quality and Drainage (1999)

Storm-water runoff from highway pavement is capable of mobilizing and transporting a wide gradation of particulates and solids. A significant fraction of this particulate matter is generated from traffic activities, including the abrasion between tires and pavement. Particulate accumulation and characteristics from an urban Interstate pavement site are investigated. The southbound asphalt pavement section studied consisted of four traveled lanes and two paved shoulders with a measured average daily traffic of 110,000. The pavement section has a transverse slope of 0.020 m/m and a longitudinal slope of 0.004 m/m. Recovery of deposited particulate matter indicates that accumulation of particulate matter along the east paved shoulder (the downslope shoulder) is significantly greater than that along the the west paved shoulder (the upslope shoulder) or the pavement. Particles larger than 25 μm were separated mechanically to generate particle size distributions (PSDs) and also to separate particles for further analysis. The east shoulder PSDs were consistently coarser across the entire size gradation than the west shoulder and pavement PSDs. Particle specific gravity ranged from 2.70 to 3.01 g/cm 3 across all gradations. Particle specific surface area increased with decreasing particle size for all gradations. In contrast, total particle surface area decreased with decreasing particle size. Integration of metal element concentration (in micrograms per gram) of zinc, copper, cadmium, and lead with the mass fraction of each particle size demonstrates that most of the metal mass is associated with the coarse to mid-range-size particles. Study results are useful for design of roadway drainage appurtenances and water quality control devices that clarify storm water mainly through the separation of particles.
Immunostimulatory Effects Triggered by Self‐Assembled Microspheres with Tandem Repeats of Polymerized RNA Strands (2019)

Self-assembled RNA particles have been exploited widely to maximize the therapeutic potential of RNA. However, the immune response via RNA particles is not fully understood. In addition, the investigation of the immunogenicity from RNA-based particles is required owing to inherent immunostimulatory effects of RNA for clinical translation. To examine the immune stimulating potency, rationally designed microsized RNA particles, called RNA microspheres (RMSs), are generated with single or double strands via rolling circle transcription. The RMSs show an exceptional stability in the presence of serum, while they are selectively degraded under endolysosomal conditions. With precisely controlled size, both RMSs are successfully taken up by macrophages. Unlike the nature of RNA fragments, RMSs induce only basal-level expression of inflammatory cytokines as well as type I interferon from macrophages, suggesting that RMSs are immunocompatible in the therapeutic dose range. Taken together, this study could help accelerate clinical translation and broaden the applicability of the self-assembled RNA-based particles without being limited by their potential immunotoxicity, while a systematic controllability study observing the release of RNA fragments from RMSs would provide self-assembled RNA-based structures with a great potential for immunomodulation.
PGSS‐Drying‐Verfahren – Schonende Trocknung empfindlicher Lebensmittel (2005)

S.1197-1198
Breeding for high water-use efficiency (2004)

There is a pressing need to improve the water-use efficiency of rain-fed and irrigated crop production. Breeding crop varieties with higher water-use efficiency is seen as providing part of the solution. Three key processes can be exploited in breeding for high water-use efficiency: (i) moving more of the available water through the crop rather than it being wasted as evaporation from the soil surface or drainage beyond the root zone or being left behind in the root zone at harvest; (ii) acquiring more carbon (biomass) in exchange for the water transpired by the crop, i.e. improving crop transpiration efficiency; (iii) partitioning more of the achieved biomass into the harvested product. The relative importance of any one of these processes will vary depending on how water availability varies during the crop cycle. However, these three processes are not independent. Targeting specific traits to improve one process may have detrimental effects on the other two, but there may also be positive interactions. Progress in breeding for improved water-use efficiency of rain-fed wheat is reviewed to illustrate the nature of some of these interactions and to highlight opportunities that may be exploited in other crops as well as potential pitfalls. For C3 species, measuring carbon isotope discrimination provides a powerful means of improving water-use efficiency of leaf gas exchange, but experience has shown that improvements in leaf-level water-use efficiency may not always translate into higher crop water-use efficiency or yield. In fact, the reverse has frequently been observed. Reasons for this are explored in some detail. Crop simulation modelling can be used to assess the likely impact on water-use efficiency and yield of changing the expression of traits of interest. Results of such simulations indicate that greater progress may be achieved by pyramiding traits so that potential negative effects of individual traits are neutralized. DNA-based selection techniques may assist in such a strategy.
Injection of FGD Grout to Abate Acid Mine Drainage in Underground Coal Mines (1997)

Acid Mine Drainage (AMD) from abandoned underground coal mines in Ohio is a concern for both residents and regulatory agencies. Effluent from these mines is typically characterized by low pH and high iron and sulfate concentrations and may contaminate local drinking-water supplies and streams. The objective of this project is to demonstrate the technical feasibility of injecting cementitious alkaline materials, such as Flue Gas Desulfurization (FGD) material to mitigate current adverse environmental impacts associated with AMD in a small, abandoned deep mine in Coshocton County Ohio. The Flue Gas Desulfurization material will be provided from American Electric Power`s (AEP) Conesville Plant. It will be injected as a grout mix that will use Fixated Flue Gas Desulfurization material and water. The subject site for this study is located on the border of Coshocton and Muskingum Counties, Ohio, approximately 1.5 miles south-southwest of the town of Wills Creek. The study will be performed at an underground mine designated as Mm-127 in the Ohio Department of Natural Resources register, also known as the Roberts-Dawson Mine. The mine operated in the mid-1950s, during which approximately 2 million cubic feet of coal was removed. Effluent discharging from the abandoned mine entrances has low pH in the range of 2.8-3.0 that drains directly into Wills Creek Lake. The mine covers approximately 14.6 acres. It is estimated that 26,000 tons of FGD material will be provided from AEP`s Conesville Power Plant located approximately 3 miles northwest of the subject site.
Developing a flexible content model for media repositories (2009)

This article describes the process and challenges of developing a content model that can support the content and metadata present in a complex media archive. Media archives have some of the most diverse requirements in an effort to catalog, preserve, and make accessible a wide range of content with multifaceted relationships between works. We focus particularly on the design and implementation of the WGBH Media Library and Archives' Fedora digital access repository for scholars, educational users and the public. It is our hope that the process and findings from this work can support the architecture and development of other media archives.
Numerical Simulation of Condensation on a Capillary Grooved Structure (2000)

Abstract Condensation in a capillary grooved structure is investigated using the Volume of Fluid (VOF) model. The governing equations are written in a generalized form and are applicable to both liquid and vapor phases. Condensation on the fin top and at the meniscus is modeled by introducing additional source terms in the continuity, VOF, and energy equations. The effects of temperature drop, contact angle, surface tension, and fin thickness on the condensation heat transfer are investigated.
Context-sensitive Content Representation for Static Document (2005)

Due to the convenience of pervasive information environment, many people use various computing devices to perform plenty kinds of tasks. In the field of education, there are various applications to facilitate learner, especially for e-learning. However, some computing devices suffer from the limited resources and cannot accept rich information content. Therefore, the information content has to be tailored into different kinds of presentation depending on the types of computing devices. Context sensitivity is an application software system's ability to sense and analyze context from various sources. In this paper, we aim to customize static documents using context-sensitive middleware (CSM) to sense the computing device, and then using the agent-based parser to provide suitable content representation dynamically.
β‐Strand Mimicry: Exploring Oligothienylpyridine Foldamers (2016)

Protein–protein interactions (PPIs) are involved in many cellular processes; consequently, the discovery of small molecules as modulators of PPIs has become an important challenge in medicinal chemistry. Structural mimetics of α‐helices, β‐turns or β‐strands could maintain or restore biological functions and should possess biological activity. At this time, the most challenging classes of PPIs are those mediated by β‐sheet interactions, which are implicated in a number of diseases. Only a few β‐strand mimics have been published to date. This study presents an evaluation of oligothienylpyridyl scaffolds in view of their ability for β‐strand mimicry. In this study, theoretical ring twist angle predictions for these scaffolds have been validated by X‐ray diffraction and molecular dynamics simulations with NMR constraints. Careful choice of substituent and heavy‐atom positions in the foldamer units opens the way to produce reasonably coplanar compounds mimicking β‐strand side‐chain distribution.
Inhibition of fibroblast hyaluronic acid production by suramin. (1993)

Hyaluronic acid (HA) is an extracellular matrix glycosaminoglycan localized in the stroma of solid tumors, where it facilitates cell movement and thus tumor invasion and metastasis. This localization of HA is due to its synthesis by stromal fibroblasts in response to paracrine factors produced by the tumor. Such tumor-stromal interactions have been shown to be crucial to the development and progression of prostate cancer. Suramin is an effective antitumor agent in hormone-refractory prostate cancer, but its mechanism(s) of action is not well understood. However, the properties of suramin as an agent which disrupts growth factor action, and the importance of tumor-stroma interactions in prostate tumor development and in HA synthesis led us to study the effect of suramin on HA synthesis. Suramin inhibited HA synthesis by calf serum-stimulated Swiss 3T3 fibroblasts at clinically relevant concentrations (IC50 = 183 micrograms/mL). Increasing the serum concentration from 10 to 20% did not change the IC50 for HA synthesis, but increased the IC50 for [3H]thymidine incorporation from 206 to 342 micrograms/mL, indicating that the antiproliferative effect of suramin can be dissociated from its effect on HA synthesis. Suramin did not alter the cellular concentrations of the two precursors for HA synthesis (UDP-glucuronic acid and UDP-N-acetylglucosamine) at early time points and did not inhibit the HA synthetase activity of isolated membranes at concentrations up to 800 micrograms/mL.(ABSTRACT TRUNCATED AT 250 WORDS)
Soil Fertility Amendments and White Grub Populations of Turf (2014)

Liming materials, calcium carbonate versus calcium magnesium silicate, were compared for effects on native white grub (Coleoptera: Scarabaeidae) populations in a New Jersey lawn. A silt loam soil near Princeton, N.J., of mixed cool-season turf with an initial pH of 5.0 received applications of either liming material in January 2007 for a target pH of 6.5. Control plots received no lime application. Grub numbers were reduced by more than 50% in plots amended with either calcium magnesium silicate or calcium carbonate when compared with the controls. Both calcium magnesium silicate and calcium carbonate were similarly effective in achieving this benefit.
Goodness-of-fit tests for parametric models in censored regression (2007)

In this talk, a new goodness-of-fit test for parametric regression models when
the response variable is right censored will be presented. The test is based on the
comparison of a parametric estimator and a nonparametric estimator of the distribution
of the errors of the regression model.We propose Kolmogorov-Smirnov
and Cramer-von Mises type statistics, and we use a bootstrap mechanism in order
to approximate the critical values of the test. Some simulations and an
application to real data will be shown.
This is joint work with Ingrid Van Keilegom and Wenceslao Gonz´alez Manteiga,
and it has been recently published in The Canadian Journal of Statistics.
Multiple Cracks in Three-Dimensional (3-D) Unidirectional Composites: Compliance and Energy Release Rates (1991)

A three-dimensional unidirectional composite with fibers aligned along the loading direction and containing planar multiple cracks is analyzed for its fracture behavior. The stresses and displacements are determined using a consistent shear lag formulation that accounts for the load-carrying capacity of the matrix in the longitudinal and transverse directions. The cracks are of equal size and distributed uniformly along the load axis. The change in compliance and energy release rates are obtained as functions of crack size (area) and spacing (crack density). The results show that the growth of existing cracks occurs more easily than multiplication of cracks, that is, formation of new cracks.
A Location-Context Awareness Mobile Services Collaborative Recommendation Algorithm Based on User Behavior Prediction (2017)

Nowadays, location based services (LBS) has become one of the most popular applications with the rapid development of mobile Internet technology. More and more research is focused on discovering the required services among massive information according to the personalized behavior. In this paper, a collaborative filtering (CF) recommendation algorithm is presented based on the Location-aware Hidden Markov Model (LHMM). This approach includes three main stages. First, it clusters users by making a pattern similarity calculation of their historical check-in data. Then, it establishes the location-aware transfer matrix so as to get the next most similar service. Furthermore, it integrates the generated LHMM, user's score and interest migration into the traditional CF algorithm so as to generate a final recommendation list. The LHMM-based CF algorithm mixes the geographic factors and personalized behavior and experimental results show that it outperforms the state-of-the-art algorithms on both precision and recall.
Data Supplement from Redirected T-Cell Killing of Solid Cancers Targeted with an Anti-CD3/Trop-2–Bispecific Antibody Is Enhanced in Combination with Interferon-α (2023)

&lt;p&gt;Results for analysis of (E1)-3s by SE-HPLC (Fig S1), SDS-PAGE (Fig S2), LC-MS (Fig S3) and Biacore (Fig S4).&lt;/p&gt;
Highly active and selective catalysts for the production of methyl propanoate via the methoxycarbonylation of ethene (1999)

A highly active and selective catalyst for the production of methyl propanoate via the methoxycarbonylation of ethene is described, based on the new zero valent palladium complex L2Pd(dba) [where L2 = 1,2-bis(di-tert-butylphosphinomethyl)benzene and dba = trans,trans-dibenzylideneacetone].
Plasma membrane H+‐ATPase activity is involved in adaptation of tomato calli to NaCl (2001)

A tomato (Lycopersicon esculentum Mill. cv. Pera) callus culture tolerant to NaCl was obtained by successive subcultures of NaCl-sensitive calli in medium supplemented with 50 mM NaCl. NaCl-tolerant calli grew better than NaCl-sensitive calli in media supplemented with 50 and 100 mM NaCl. Analysis of callus ion content showed a strong increase in Na+ and Cl- both in NaCl-tolerant and -sensitive calli grown in media containing NaCl for one subculture. Cells from NaCl-tolerant calli showed a higher H+ extrusion activity than those from NaCl-sensitive calli grown for one subculture in the presence of NaCl. The inhibition of H+ extrusion by NaCl-sensitive cells was correlated with an inhibition of microsomal vanadate-sensitive H+-ATPase (EC 3.6.1.35) and ATP-dependent H+ transport, while the stimulation of H+ extrusion by cells tolerant to 50 mM NaCl was correlated with an increase in plasma membrane ATP-dependent H+ transport. The increase of ATP-dependent H+ extrusion in plasma membranes isolated from 50 mM NaCl-tolerant calli was not a result of stimulation of a vanadate-sensitive ATP hydrolytic activity or an increase in passive permeability to H+. Relative to NaCl-sensitive calli, plasma membrane H+-ATPase from calli tolerant to 50 mM NaCl showed a lower Km for Mg2+-ATP. Our results indicate that tolerance of tomato calli to 50 mM NaCl increases the affinity of plasma membrane H+-ATPase for the substrate ATP and stimulates the H+-pumping activity of this enzyme without modifying its phosphohydrolytic activity.
[Cervical spondylolysis in children. Apropos of 4 cases. Review of the literature]. (1995)

Cervical spondylolysis in the child is a rare congenital disorder. It must be distinguished from the congenital absence of a pedicle and from a pedicle or isthmic fracture. It is a lesion which is normally discovered once the patient has turned adult and is very well long term tolerated.