gebhart/patrepeval huggingface dataset:
C3D: Mitigating the NUMA bottleneck via coherent DRAM caches (2016)

Massive datasets prevalent in scale-out, enterprise, and high-performance computing are driving a trend toward ever-larger memory capacities per node. To satisfy the memory demands and maximize performance per unit cost, today's commodity HPC and server nodes tend to feature multi-socket shared memory NUMA organizations. An important problem in these designs is the high latency of accessing memory on a remote socket that results in degraded performance in workloads with large shared data working sets. This work shows that emerging DRAM caches can help mitigate the NUMA bottleneck by filtering up to 98% of remote memory accesses. To be effective, these DRAM caches must be private to each socket to allow caching of remote memory, which comes with the challenge of ensuring coherence across multiple sockets and GBs of DRAM cache capacity. Moreover, the high access latency of DRAM caches, combined with high inter-socket communication latencies, can make hits to remote DRAM caches slower than main memory accesses. These features challenge existing coherence protocols optimized for on-chip caches with fast hits and modest storage capacity. Our solution to these challenges relies on two insights. First, keeping DRAM caches clean avoids the need to ever access a remote DRAM cache on a read. Second, a non-inclusive on-chip directory that avoids tracking blocks in the DRAM cache enables a light-weight protocol for guaranteeing coherence without the staggering directory costs. Our design, called Clean Coherent DRAM Caches (C <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> D), leverages these insights to improve performance by 6.4-50.7% in a quad-socket system versus a baseline without DRAM caches.
The establishment of neuronal properties is controlled by Sox4 and Sox11 (2006)

The progression of neurogenesis relies on proneural basic helix-loop-helix (bHLH) transcription factors. These factors operate in undifferentiated neural stem cells and induce cell cycle exit and the initiation of a neurogenic program. However, the transient expression of proneural bHLH proteins in neural progenitors indicates that expression of neuronal traits must rely on previously unexplored mechanisms operating downstream from proneural bHLH proteins. Here we show that the HMG-box transcription factors Sox4 and Sox11 are of critical importance, downstream from proneural bHLH proteins, for the establishment of pan-neuronal protein expression. Examination of a neuronal gene promoter reveals that Sox4 and Sox11 exert their functions as transcriptional activators. Interestingly, the capacity of Sox4 and Sox11 to induce the expression of neuronal traits is independent of mechanisms regulating the exit of neural progenitors from the cell cycle. The transcriptional repressor protein REST/NRSF has been demonstrated to block neuronal gene expression in undifferentiated neural cells. We now show that REST/NRSF restricts the expression of Sox4 and Sox11, explaining how REST/NRSF can prevent precocious expression of neuronal proteins. Together, these findings demonstrate a central regulatory role of Sox4 and Sox11 during neuronal maturation and mechanistically separate cell cycle withdrawal from the establishment of neuronal properties.
An Archaeometric Investigation into the Former Cataract House Hotel via Elemental Analysis (2022)

Over the course of the 19th century, the former Cataract House Hotel of Niagara Falls, New York, became one of the largest hotels in the region while also serving as an important “station” on the Underground Railroad. A park now occupies the area covering its demolished ruins. Since 2017, archaeological excavations of the site have taken place, led by the Anthropology Department at SUNY Buffalo. Although much is known about the overall design of the Cataract House Hotel, a clearer understanding of its construction phases, as well as its role in the Underground Railroad, could be determined from spectroscopic analysis in tandem with ongoing archaeological investigations. In 2022, in situ data collection was performed on plaster walls at the excavation site using a portable X-ray fluorescence (pXRF) instrument. These elemental data were used in conjunction with archaeological information to form conclusions regarding different construction phases of the hotel. Samples of plaster walls were also collected for further ex situ analyses with pXRF and portable laser-induced breakdown spectroscopy (pLIBS) in a laboratory setting. Future work will include data collection and analysis by additional spectroscopic methods of other artifacts collected at the site, such as pigment samples removed from an unearthed stone step.
Conjugation of R-Phycoerythrin to a Polyclonal Antibody and F (ab')2 Fragment of a Polyclonal Antibody by Two Different Methods. (2010)

R-Phycoerythrin (R-PE), a fluorescent protein from phycobiliprotein family, is isolated from red algae. Conjugation of antibodies to R-PE facilitates multiple fluorescent staining methods. In the present study polyclonal antibodies and polyclonal F(ab')2 fragment antibodies were conjugated to R-PE by two different methods. The efficiency of the methods was evaluated using Immunocytochemistry (ICC) and Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE). In the first conjugation method, PE was attached to SMCC linker followed by conjugation of antibody to PE-SMCC. In the second method, SH groups were added onto R-PE molecule, while the antibody was attached to SPDP linker. Then, the antibody-SPDP molecule was conjugated to R-PE. Our results showed that the two conjugation methods did not have any abrogative effects on the antibody binding activity.
High-Speed Interferometric Detection of Label-Free Immunoassays on the Biological Compact Disc (2006)

High-speed interferometric detection of label-free protein assays on a rapidly spinning BioCD is a high-sensitivity approach that is amenable to scaling up to many analytes.
A comprehensive scheduler for asymmetric multicore systems (2010)

Symmetric-ISA (instruction set architecture) asymmetric-performance multicore processors were shown to deliver higher performance per watt and area for applications with diverse architectural requirements, and so it is likely that future multicore processors will combine a few fast cores characterized by complex pipelines, high clock frequency, high area requirements and power consumption, and many slow ones, characterized by simple pipelines, low clock frequency, low area requirements and power consumption. Asymmetric multicore processors (AMP) derive their efficiency from core specialization. Efficiency specialization ensures that fast cores are used for "CPU-intensive" applications, which efficiently utilize these cores' "expensive" features, while slow cores would be used for "memory-intensive" applications, which utilize fast cores inefficiently. TLP (thread-level parallelism) specialization ensures that fast cores are used to accelerate sequential phases of parallel applications, while leaving slow cores for energy-efficient execution of parallel phases. Specialization is effected by an asymmetry-aware thread scheduler, which maps threads to cores in consideration of the properties of both. Previous asymmetry-aware schedulers employed one type of specialization (either efficiency or TLP), but not both. As a result, they were effective only for limited workload scenarios. We propose, implement, and evaluate CAMP, a Comprehensive AMP scheduler, which delivers both efficiency and TLP specialization. Furthermore, we propose a new light-weight technique for discovering which threads utilize fast cores most efficiently. Our evaluation in the OpenSolaris operating system demonstrates that CAMP accomplishes an efficient use of an AMP system for a variety of workloads, while existing asymmetry-aware schedulers were effective only in limited scenarios.
Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. (1990)

Interleukin 6 (IL-6) is a cytokine that acts on various cell types. Here we show that IL-6 mRNA is produced in vivo in two self-limiting physiologic angiogenic processes: (i) the formation of the vascular system accompanying development of ovarian follicles and (ii) the formation of a capillary network in the maternal decidua following embryonic implantation. In situ and RNA blot hybridization analyses detected transient expression of IL-6 mRNA in gonadotropin-primed hyperstimulated ovaries, with maximal mRNA levels coinciding with the period of formation of a capillary network around follicles. Expression of IL-6 mRNA was detected in the vasculature extending from the ovarian medulla to the forming capillary sheath in the thecal layer of individual growing follicles. No expression was detected in more-developed preovulatory follicles once angiogenesis had been completed. IL-6 mRNA was also detected in the uterus of pregnant mice 9.5 days postcoitum, and there was no appreciable IL-6 mRNA at later stages of embryonic development. Expression in the uterus was confined to cords of endothelial cells in the process of formation of an anastomosing network that traversed the maternal decidua towards the developing embryo. The expression of IL-6 mRNA in two independent physiological angiogenic processes and the transient nature of its expression in endothelial cells suggest a role for IL-6 in angiogenesis.
Improve carbon metabolic flux inSaccharomyces cerevisiaeat high temperature by overexpressedTSL1gene (2013)

This study describes a novel strategy to improve the glycolysis flux of Saccharomyces cerevisiae at high temperature. The TSL1 gene-encoding regulatory subunit of the trehalose synthase complex was overexpressed in S. cerevisiae Z-06, which increased levels of trehalose synthase activity in extracts, enhanced stress tolerance and glucose consuming rate of the yeast cells. As a consequence, the final ethanol concentration of 185.5 g/L was obtained at 38 °C for 36 h (with productivity up to 5.2 g/L/h) in 7-L fermentor, and the ethanol productivity was 92.7 % higher than that of the parent strain. The results presented here provide a novel way to enhance the carbon metabolic flux at high temperature, which will be available for the purposes of producing other primary metabolites of commercial interest using S. cerevisiae as a host.
Single Si crystal 1024 ch MEMS mirror based on terraced electrodes and a high-aspect ratio torsion spring for 3-D cross-connect switch (2003)

Packaged large scale 1024 ch (32/spl times/32) mirror array switch module is presented for an optical cross-connect utilizing two-axis mirrors for beam steering. Besides being small, only 170/spl times/130 mm in size, the mirror array features a highly stable switching characteristics because of a tough mirror support and high-aspect-ratio torsion spring, very small warpage of ten nanometer order, and low applied voltage.
Interchange of functional domains switches enzyme specificity: construction of a chimeric pneumococcal‐clostridial cell wall lytic enzyme (1993)

Bacterial autolysins are endogenous enzymes that specifically cleave covalent bonds in the cell wall. These enzymes show both substrate and bond specificities. The former is related to their interaction with the insoluble substrate whereas the latter determine their site of action. The bond specificity allows their classification as muramidases (lysozymes), glucosaminidases, amidases, and endopeptidases. To demonstrate that the autolysin (LYC muramidase) of Clostridium acetobutylicum ATCC824 presents a domainal organization, a chimeric gene (clc) containing the regions coding for the catalytic domain of the LYC muramidase and the choline-binding domain of the pneumococcal phage CPL1 muramidase has been constructed by in vitro recombination of the corresponding gene fragments. This chimeric construction codes for a choline-binding protein (CLC) that has been purified using affinity chromatography on DEAE-cellulose. Several biochemical tests demonstrate that this rearrangement of domains has generated an enzyme with a choline-dependent muramidase activity on pneumococcal cell walls. Since the parental LYC muramidase was choline-independent and unable to degrade pneumococcal cell walls, the formation of this active chimeric enzyme by exchanging protein domains between two enzymes that specifically hydrolyse cell walls of bacteria belonging to different genera shows that a switch on substrate specificity has been achieved. The chimeric CLC muramidase behaved as an autolytic enzyme when it was adsorbed onto a live autolysin-defective mutant of Streptococcus pneumoniae. The construction described here provides experimental support for the theory of modular evolution which assumes that novel proteins have evolved by the assembly of preexisting polypeptide units.
Targeting hypoxic prostate tumours using the novel hypoxia-activated prodrug OCT1002 inhibits expression of genes associated with malignant progression (2016)

PurposeHypoxia is a common hallmark of the tumour microenvironment. Recently we have shown the anti-androgen bicalutamide induces profound hypoxia in prostate tumours in vivo. This resulted in the promotion of epithelial to mesenchymal transition. Here we target tumour hypoxia using a novel unidirectional hypoxia-activated prodrug OCT1002 to enhance the anti-tumour effect of bicalutamide. Experimental Design The effect of OCT1002 treatment on LNCaP-luc cells was measured in normoxia and hypoxia in vitro. In vivo, tumour growth and lung metastases were measured in mice treated with bicalutamide, OCT1002 or a combination. Dorsal skin fold chambers were used to image tumour vasculature in vivo. Longitudinal genetic changes in tumours were analysed using PCR.Results Reduction of OCT1002 to its active form (OCT1001) decreased LNCaP-luc cell viability. In LNCaP-luc spheroids, OCT1002 caused increased apoptosis and decreased clonogenicity. In vivo, treatment with OCT1002 alone or with bicalutamide, showed significantly greater tumour growth control and reduced lung metastases compared to controls. Re-establishment of the tumour vasculature following bicalutamide-induced vascular collapse is inhibited by OCT1002. Significantly, the up-regulation of RUNX2 and its targets caused by bicalutamide alone were also blocked by OCT1002. Conclusions OCT1002 selectively targets hypoxic tumour cells and enhances the anti-tumour efficacy of bicalutamide. Furthermore, bicalutamide causes changing genetic profiles during treatment, with development of a more malignant genotype; OCT1002 can block this effect. This study indicates that more attention should be attached to understanding genetic changes that may occur during treatment. Early targeting of hypoxic cells with OCT1002 can provide a means of inhibiting prostate tumour growth and malignant progression.
PERCEIVED RISK AND ESCROW ADOPTION: AN ECONOMIC ANALYSIS IN ONLINE CONSUMER-TO-CONSUMER AUCTION MARKETS (2001)

Online escrow is an emerging trust service in consumer-to-consumer auction markets for protecting online traders from Internet fraud. Although the process of online escrow services (OES) ensures its effectiveness i blocking Internet frauds, its adoption rate is still surprisingly low relative to the increasing Internet fraud (Fraud.org 2001; Wolverton 2001). This paper intends to study the effect of tradersiÌ perceived risk (Kahneman and Tversky 1979; Weber and Milliman 1999), defined as perceived risk rate (PRR), on the adoption of online escrow service. The research applies economic modeling and computer simulation approaches, following the literature and methodology in Hu et al.(2001).
1,10-Phenanthroline inhibition of lymphoblast cell cycle. (1977)

The effects of the metal-chelating agent, 1,10-phenanthroline (OP), on the cell cycle progression of CCRF-CEM lymphoblasts has been studied by flow microfluorometry. Lymphoblasts were incubated with 2,3-dihydro-1H-imidazo[1,2-b]pyrazole in order to block them in G1-early S. The block was then reversed by incubating the cells in fresh media. Within 2 to 4 hr, approximately 90% of the cells were in S phase and, by 6 hr, approximately 80% were in late S. Aliquots of these latter cells then were incubated with podophyllotoxin to block them in G2-M. These cells divided within 4 hr of reversal of the podophyllotoxin block. Lymphoblast populations in G1-early S, mid-S, or G2-M were then incubated with 4 micronM OP. OP blocked entry of G1 cells into S as well as progression through S but had no effect on progression from G2-M to G1. The OP effects were reversed by addition of Zn2+, Cu2+, or Fe2+ or by dilution of the chelating agent in the growth media. Incubation of CCRF-CEM lymphoblasts with 1,7-phenanthroline, a nonchelating analog of OP, did not affect the cell cycle. The data indicate that OP reversibly blocks progression of cells from G1 to S and through S by chelation of metals involved in processes essential for those cell cycle events.
Deep-submicrometer channel design in silicon-on-insulator (SOI) MOSFET's (1994)

Short-channel effects in deep-submicrometer SOI MOSFET's are explored over a wide range of device parameters using two-dimensional numerical simulations. To obtain reduced short-channel effects in SOI over bulk technologies, the silicon film thickness most be considerably smaller than the bulk junction depth because of an additional charge-sharing phenomenon through the SOI buried oxide. The optimal design space, considering nominal and short-channel threshold voltage, shows ample design options for both fully and partially depleted devices, however, manufacturing considerations in the 0.1 μm regime may favor partially depleted devices.
A Comparison Study of the Bondability and Reliability Performance of Au Bonding Wires with Different Dopant Levels (2007)

Over 90% of all interconnection methods in the semiconductor industry are using gold bonding wire. As the industry migrates into smaller unit size for electronic products, thinner wires are required. The general lower break load and decreased reliability of small wires drives the need for stronger and higher dopant concentration wires. This has prompted a market focus on 2N and 3N wires. In this study, 2N and 3N wires of similar dopants are compared based on both bondability and reliability. Studies indicate that 3N wires display a larger 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> bond window, while 2N wires reveal a short tail that limits bonding. On the other hand, 2N wires show superior reliability performance with no ball lift up to 10,000 hrs at 175degC. For 3N wires, a significant numbers of ball lifts were observed at comparable condition.
Synthesis and Characterization of [NH2C(I):NH2]3MI5 (M = Sn, Pb): Stereochemical Activity in Divalent Tin and Lead Halides Containing Single .ltbbrac.110.rtbbrac. Perovskite Sheets (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Characterization of [NH2C(I):NH2]3MI5 (M = Sn, Pb): Stereochemical Activity in Divalent Tin and Lead Halides Containing Single .ltbbrac.110.rtbbrac. Perovskite SheetsShumin Wang, David B. Mitzi, Chris A. Feild, and Arnold GuloyCite this: J. Am. Chem. Soc. 1995, 117, 19, 5297–5302Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/ja00124a012https://doi.org/10.1021/ja00124a012research-articleACS PublicationsRequest reuse permissionsArticle Views3529Altmetric-Citations255LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
More Informative Abstracts of Articles Describing Clinical Practice Guidelines (1993)

key persons or groups that developed, funded, or endorsed the guideline. Abstracts adhering to these recommendations could enhance readers' ability to appraise the applicability, importance, and validity of guidelines for specific providers, patients, and settings. More informative abstracts could also promote the use of more explicit methods of guideline development, more consistent reporting of guideline documents, and the more appropriate use of guidelines by clinicians.
Mental Distress, Obesity and Body Fat Distribution in Middle‐Aged Men (1996)

Previous epidemiological studies have suggested that psychiatric symptoms are associated with obesity and abdominal distribution of body fat in women. The aim of the present study was to examine this in middle-aged men. In 1992 a cluster selected cohort of 1040 men born in 1944 (participation rate 79.9%) was examined. Registrations of symptoms of depression and anxiety, sleep disturbances, psychosomatic disease as well as degree of life satisfaction were analyzed in relation to body mass index (BMI) and the waist/hip circumference ratio (WHR). In univariate analyses both BMI and WHR correlated with these factors. BMI and WHR were, however, closely interrelated (p = 0.61), necessitating analyses of separate, independent relationships in multivariate analyses. When adjusted for WHR all the significant relationships with BMI disappeared. In contrast the WHR, adjusted for BMI, showed remaining significant associations with the use of anxiolytics (p = 0.018), hypnotics (p = 0.029), antidepressive drugs (p = 0.008), degree of melancholy (p = 0.002), and life satisfaction (p = 0.002, negative), difficulties to sleep (p = 0.014) and fall asleep (p = 0.047), tendency to wake up from sleep (borderline, p = 0.070) and dyspepsia (p < 0.001). Since smoking and alcohol are known to influence on the WHR, these factors were, in addition to BMI, entered into the analyses as confounding variables. The mentioned associations then remained statistical significant (use of hypnotics borderline, p = 0.074) except difficulties to fall asleep and tendency to wake up. It was concluded that in contrast to BMI, the WHR is associated with symptoms of depression and anxiety with associated sleep disturbances, as well as psychosomatic symptoms and dissatisfaction. It was hypothesized that the mechanism involved might be increased secretion of cortisol, directing storage fat to central adipose tissue depots.