gebhart/patrepeval huggingface dataset:
TOWARDS NOVEL CIRCULATING MARKERS FOR ABDOMINAL AORTIC ANEURYSM PROGNOSIS (2021)

Objective: Abdominal aortic aneurysm (AAA) is increasing due to aging of the population and is a major cause of death among the elderly. Ultrasound screening programs are useful in early diagnosis but aneurysm size is not always a good predictor of rupture. Thus, there is an urgent need to find new potential prognostic factors. Our aim is to determine whether a battery of immune, inflammatory and oxidative stress markers, previously described to be involved in other cardiovascular diseases, may be used as potential biomarkers to provide personalized prediction of AAA progression for the clinical practice. Design and method: To address this, human abdominal aneurysmatic aortas (N = 80) and blood samples (N = 94) were obtained from patients undergoing open repair or endovascular surgery repair for AAA, whereas healthy aortas (n = 15) and blood samples (n = 46) were obtained from healthy donors. We studied the immune infiltrate in paraffin sections of human aneurysmatic tissue and quantified IgM and IgG circulating levels in our AAA patient cohort. Circulating levels of ROS, CD38, CD36, GDF15 and S100A4 were measured by ELISA and their tissue expression was studied by real Time PCR and by immunostaining. Potential correlations with the aneurysm diameter or with peak wall stress, determined by finite element analysis, were measured by the Pearson product-moment correlation. Results: Our study shows for the first time the alteration of IgM, IgG, ROS, CD38, GDF15 and S100A4 levels in plasma and in aneurysmatic tissue of AAA patients in comparison with controls. After performing the corresponding statistical analysis we could exclude age and sex as confounding factors of our current observations. Circulating levels of IgG, CD38 and GDF15 were positively correlated with abdominal aortic diameter and peak wall stress. Conclusions: Our data indicate that IgG, CD38 and GDF15 may have potential to aid AAA prognosis as indicators of the progression of the aneurysm growth.
Schema versioning: queries to the generalized temporal database system (1999)

Raw data and database structures are evolving entities that require adequate support for past, present and even future versions. Temporal databases supporting schema versioning were developed with the aim of satisfying this requirement. This paper considers a generalized temporal database system, which provides support for time at both intensional and extensional levels. The support for schema versioning raises two complex subjects: the storage of the several schema versions and their associate data, and the processing of queries involving more than one schema version. The main goal of this paper is to analyse the second aspect in order to propose a strategy to answer multi-schema queries.
Data from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; A positive response to gefitinib in non–small cell lung cancer (NSCLC) has been correlated to mutations in epidermal growth factor receptor (EGFR) gene. Previous reports have been based mainly on diagnostic screening by sequencing. However, sequencing is a time-consuming and complicated procedure, not suitable for routine clinical use.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We have developed rapid, simple, and sensitive mutation detection assays based on the SMart Amplification Process (SMAP) and applied it for analyzing EGFR gene mutations in clinical samples. By using SMAP, we can detect mutations within 30 min including sample preparation. To validate the assay system for potential use in clinical diagnostics, we examined 45 NSCLC patients for EGFR mutations using sequencing and SMAP.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; The outcomes of the SMAP assay perfectly matched the sequencing results, except in one case where SMAP was able to identify a mutation that was not detected by sequencing. We also evaluated the sensitivity and specificity of SMAP in mutation detection for EGFR. In a serial dilution study, SMAP was able to find a mutation in a sample containing only 0.1% of the mutant allele in a mixture of wild-type genomic DNA. We also could show amplification of mutated DNA with only 30 copies per reaction.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; The SMAP method offers higher sensitivity and specificity than alternative technologies, while eliminating the need for sequencing to identify mutations in the EGFR gene of NSCLC. It provides a robust and point-of-care accessible approach for a rapid identification of most patients likely to respond to gefitinib.&lt;/p&gt;&lt;/div&gt;
Prolonged turns in interpreting (1998)

This paper seeks to investigate the effect of increased time on task in simultaneous interpreting on the quality of interpretation and on physiological and psychological stress. Interpreters working for longer than approx. 30 minutes, the recommended turn time in simultaneous interpreting under standard working conditions, risk a decline in quality of output which appears to be due to a combination of psychological and physiological factors.
A data-driven and probabilistic approach to residual evaluation for fault diagnosis (2011)

An important step in fault detection and isolation is residual evaluation where residuals, signals ideally zero in the no-fault case, are evaluated with the aim to detect changes in their behavior caused by faults. Generally, residuals deviate from zero even in the no-fault case and their probability distributions exhibit non-stationary features due to, e.g., modeling errors, measurement noise, and different operating conditions. To handle these issues, this paper proposes a data-driven approach to residual evaluation based on an explicit comparison of the residual distribution estimated on-line and a no-fault distribution, estimated off-line using training data. The comparison is done within the framework of statistical hypothesis testing. With the Generalized Likelihood Ratio test statistic as starting point, a more powerful and computational efficient test statistic is derived by a properly chosen approximation to one of the emerging likelihood maximization problems. The proposed approach is evaluated with measurement data on a residual for diagnosis of the gas-flow system of a Scania truck diesel engine. The proposed test statistic performs well, small faults can for example be reliable detected in cases where regular methods based on constant thresholding fail.
In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDH x Mutations in Paraganglioma (2015)

Detection of succinate by (1)H-MRS is a highly specific and sensitive hallmark of SDHx mutations. This noninvasive approach is a simple and robust method allowing in vivo detection of the major biomarker of SDHx-mutated tumors.
Quantum-mechanical 2D simulation of surface- and buried-channel p-MOS (2002)

A two-dimensional MOS device simulator including quantum-mechanical effects has been developed and applied to surface- and buried-channel p-MOS devices. The Schrodinger equation is solved, retaining a large number of eigenstates, which are then used to build a modified classical distribution accounting for the high energy part of the distribution. With this approach, discontinuities in the gate capacitance near flat bands have been eliminated without introducing any empirical parameter. For accurate device simulation, experimental data on the hole mobility were collected, and a nonlocal mobility model was used for carriers in the bound levels. A standard mobility model is adopted instead for the classically-distributed carriers. Results are presented for the gate capacitance and drain current of 0.35 /spl mu/m p-MOSFET devices, showing a good agreement over a wide range of channel doping concentrations.
Peptides and Proteins in the Vapor Phase (2000)

This article provides a review of recent studies of the properties of unsolvated (and partially solvated) peptides and proteins. The methods used to produce vapor-phase peptide and protein ions are described along with some of the techniques used to study them, such as H/D exchange, blackbody infrared radiative dissociation, and ion mobility measurements. Studies of unsolvated peptides and proteins provide information about their intrinsic intramolecular interactions. The topics covered include the role of zwitterions and salt bridges in the vapor phase, Coulomb interactions in multiply charged ions, the unfolding and refolding of vapor-phase proteins, and the stability of unsolvated helices and sheets. Finally, dehydration and rehydration studies of proteins in the vapor phase are described. These can provide exquisitely detailed information about hydration interactions, such as the enthalpy and entropy changes associated with adsorbing individual water molecules.
Rapid prototyping of a micro pump with laser micromachining (1995)

A microelectrohydrodynamic (EHD) injection pump has been developed using laser micromachining technoogy. Two desings have been fabricated, tested, and evaluated. The first design has two silicon pieces with KOH-etched wells which are stacked on the tpo of each other. The wells are etched on one side of the wafer and gold is deposited on the other side to serve as the pump electrodes. A Nd:YAG laser is used to drill an array of circular holes in the well region of both silicon parts. This creates a grid distribution with a square pattern. Next the well regions of the silicon parts are aligned, and the parts are bonded together using a Staystik thermoplastic. The pump unit is then mounted into a ceramic package with a large hole drilled in the bottom of the package to permit fluid flow. Aluminum ribbon wire bonds are used to connect the pump electrodes to the package leads. Isolation of metallization and wires is achieved by filling the package well and coating the wires with polyimide. When a voltage is applied at the electrodes, ions are injected into the working fluid, such as an organic solvent, thus inducing flow. The second design has the silicon parts oriented 'back-to-back' and bonded together with Stayform. A 'back-to-back' design will decrease the grid distance so that a smaller voltage is required for pumping. Preliminary results have demonstrated that this micropump can achieve a pressure head of about 287 Pa with an applied voltage of 120 Volt.
MAGNON SIDEBANDS AND LOCAL ORDER IN Co-DOPED MnF2 (1968)

A magnon sideband associated with an isolated Co single-ion optical transition is reported in Co-doped MnF2. Measurements of the temperature dependence of the absorption, after the subtraction of the thermal contribution to the line shift, indicates the presence of local order above the Néel temperature.
Human Herpesvirus-6 DNA in Cerebrospinal Fluid of a Child with Exanthem Subitum and Meningoencephalitis (1992)

The involvement of human herpesvirus-6 (HHV-6) and herpes simplex virus infections was evaluated virologically and serologically in a 13-month-old girl with meningoencephalitic illness occurring in the pre-eruptive stage of exanthem subitum. An isolation of HHV-6 from blood and seroconversion to the virus confirmed the primary infection with the virus. HHV-6 gene sequences were detected in cerebrospinal fluid of acute stage of the disease by polymerase chain reaction. There was no evidence of herpes simplex virus infection in blood and cerebrospinal fluid. The patient recovered from the disease without any sequelae, although abnormal electroencephalography and cerebral computed tomography findings were observed temporally in the acute stage of the disease. These findings strongly suggest that HHV-6 invades the central nervous system and causes meningoencephalitis.
Effect of ion irradiation on the thermoluminescence properties of K 2 Ca 2 (SO 4 ) 3 phosphor (2011)

This paper presents the thermoluminescence (TL) studies of ion-irradiated potassium–calcium mixed sulfate phosphor. The sample was prepared by the solid-state diffusion method. The X-ray diffraction study of the prepared sample suggests an orthorhombic structure with an average particle size of 0.16 μ m. The samples were irradiated with 1.2 MeV argon ions at fluences varying between 1011 and 1015 ions/cm2. The argon ions penetrate to a depth of 1.93 μ m and lose their energy mainly via electronic stopping. Due to ion irradiation, a large number of defects such as oxygen vacancies, radicals and color centers are formed in the sample. TL glow curves were recorded for each of the ion fluences. A linear increase in the intensity of TL glow peaks was found with an increase in the ion dose from 72 kGy to 720 MGy. The kinetic parameters associated with the prominent glow peaks were calculated using glow curve deconvolution, different glow curve shapes and sample heating rate methods.
Factor VII Activation, Apolipoprotein A-I and Reverse Cholesterol Transport: Possible Relevance for Postprandial Lipaemia (2002)

Postprandial lipaemia is associated with activation of factor VII (FVII) and efflux of cholesterol from tissues to nascent plasma high density lipoproteins (HDL) containing apolipoprotein A-I (apo A-I). To determine whether FVII activation and cholesterol efflux occur together in other situations, the responses to intravenous infusion of HDL-like apo A-I/phosphatidylcholine discs were measured in 10 healthy men. Disc infusion (40 mg apo A-I/kg body weight) over 4 h was followed by increases in HDL cholesteryl ester and plasma apo A-I (p <0.0001). Significant activation of FVII was apparent during infusion in fasting subjects (p = 0.03), activated FVII averaging 123% of baseline value by 12 h (p <0.0001). Plasma thrombin-antithrombin (TAT) complex increased to 156% of baseline level by 12 h (p >0.05) but individual responses differed considerably. Peak TAT post-infusion was associated inversely with peak HDL triglyceride concentration (p = 0.004). The coagulation responses to disc-infusion may be due to transfer of phosphatidylserine to cell surfaces during cholesterol efflux.
Construction of oxidative stress-free cell culture system to maintain cellular morphology (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Fractal Study of Coupling Transitions in Ballistic Quantum-Dot Arrays (2005)

A fractal analysis is used to characterize magnetoconductance fluctuations in an open, coupled quantum‐dot array. The fractal dimension is combined with the empirical parameter Q as a probe of the energy level spectrum in the array, and a coupling transition is identified as a function of the number of modes in the coupling quantum point contact.
Energy Resources and Global Development (2003)

In order to address the economic and environmental consequences of our global energy system, we consider the availability and consumption of energy resources. Problems arise from our dependence on combustible fuels, the environmental risks associated with their extraction, and the environmental damage caused by their emissions. Yet no primary energy source, be it renewable or nonrenewable, is free of environmental or economic limitations. As developed and developing economies continue to grow, conversion to and adoption of environmentally benign energy technology will depend on political and economic realities.
Quantifying the Composition of Human Skin for Glucose Sensor Development (2010)

Background: Glucose is heterogeneously distributed within human skin. In order to develop a glucose measurement method for human skin, both a good quantification of the different compartments of human skin and an understanding of glucose transport processes are essential. This study focused on the composition of human skin. In addition, the extent to which intersubject variability in skin composition alters glucose dynamics in human skin was investigated. Methods: To quantify the composition of the three layers of human skin—epidermis, dermis, and adipose tissue—cell and blood vessel volumes were calculated from skin biopsies. These results were combined with data from the literature. The composition was applied as input for a previously developed computational model that calculates spatiotemporal glucose dynamics in human skin. The model was used to predict the physiological effects of intersubject variability in skin composition on glucose profiles in human skin. Results: According to the model, the lag time of glucose dynamics in the epidermis was sensitive to variation in the volumes of interstitial fluid, cells, and blood of all layers. Data showed most variation/uncertainty in the volume composition of the adipose tissue. This variability mainly influences the dynamics in the adipose tissue. Conclusions: This study identified the intersubject variability in human skin composition. The study shows that this variability has significant influence on the glucose dynamics in human skin. In addition, it was determined which volumes are most critical for the quantification and interpretation of measurements in the different layers.
A histological study of seasonal ovarian development in freshwater drum in the Red Lakes, Minnesota (1995)

Female freshwater drum Aplodinotus grunniens Rafinesque, from the Red Lakes of north central Minnesota, U.S.A. were sampled periodically over a 13‐month period. Red Lakes drum mature at approximately age 9 and can live to be over 60 years old. The ovarian development of drum from its northern limit of distribution is described histologically. The stages of oocyte growth and the seasonal change in the proportion of oocyte stages within the ovaries are presented. Drum ovaries contained a continuum of oocyte sizes and at spawning, only the largest oocytes are ovulated. A large percentage of the oocytes became atretic mid‐way through the spawning season, while gonadosomatic indexes were still high. This may have reduced the spawning potential of Red Lakes drum.
The Causes of Pain in Benign Solitary Enchondromas of the Proximal Humerus (2005)

Patients with benign solitary enchondromas of the proximal humerus frequently present to the diagnosing physician with shoulder pain. Once the lesion is considered benign, emphasis can be placed on identifying the etiology for the pain. We reviewed our experience with these patients to identify the cause of the presenting pain. A retrospective review of clinical records and radiographic studies (radiographs, magnetic resonance images, and bone scans) was done for all patients presenting to an orthopaedic oncology unit with solitary enchondroma of the proximal humerus. Attention was focused on diagnostic evidence of additional disease in the shoulder. Fifty-seven patients (mean age, 53.6 years) met the criteria of the study and were included for evaluation. Of patients presenting with pain, 82% (47 of 57 patients) had findings seen on magnetic resonance imaging scans that correlated with the initial clinical diagnostic impression, suggesting that other disease was present that could explain the pain. Solitary enchondromas of the proximal humerus often are found incidentally during the initial evaluation of patients with shoulder pain. This study showed that additional treatable disease usually is present in patients with enchondromas of the proximal humerus.
Fast probabilistic algorithms for hamiltonian circuits and matchings (1977)

The main purpose of this paper is to give techniques for analysing the probabilistic performance of certain kinds of algorithms, and hence to suggest some fast algorithms with provably desirable probabilistic behaviour. The particular problems we consider are: finding Hamiltonian circuits in directed graphs (DHC), finding Hamiltonian circuits in undirected graphs (UHC), and finding perfect matchings in undirected graphs (PM). We show that for each problem there is an algorithm that is extremely fast (0(n(log n)2) for DHC and UHC, and 0(nlog n) for PM), and which with probability tending to one finds a solution in randomly chosen graphs of sufficient density. These results contrast with the known NP-completeness of the first two problems [2,12] and the best worst-case upper bound known of 0(n2.5) for the last [9].
MALT1 is a potential therapeutic target in glioblastoma and plays a crucial role in EGFR‐induced NF‐κB activation (2020)

Glioblastoma multiforme (GBM) is the most common malignant tumour in the adult brain and hard to treat. Nuclear factor κB (NF-κB) signalling has a crucial role in the tumorigenesis of GBM. EGFR signalling is an important driver of NF-κB activation in GBM; however, the correlation between EGFR and the NF-κB pathway remains unclear. In this study, we investigated the role of mucosa-associated lymphoma antigen 1 (MALT1) in glioma progression and evaluated the anti-tumour activity and effectiveness of MI-2, a MALT1 inhibitor in a pre-clinical GBM model. We identified a paracaspase MALT1 that is involved in EGFR-induced NF-kB activation in GBM. MALT1 deficiency or inhibition significantly affected the proliferation, survival, migration and invasion of GBM cells both in vitro and in vivo. Moreover, MALT1 inhibition caused G1 cell cycle arrest by regulating multiple cell cycle-associated proteins. Mechanistically, MALTI inhibition blocks the degradation of IκBα and prevents the nuclear accumulation of the NF-κB p65 subunit in GBM cells. This study found that MALT1, a key signal transduction cascade, can mediate EGFR-induced NF-kB activation in GBM and may be potentially used as a novel therapeutic target for GBM.
A multi-channel digital demodulator for LVDT and RVDT position sensors (1989)

The authors present the architecture, VLSI implementation and test results of a mixed analog-digital multichannel digital demodulator for a linear-variable-differential-transformer (LVDT) position sensor. The monolithic multichannel demodulator has four signal channels for demodulation and a built-in-test (BIT) channel. Each channel has a 12-bit Δ-Σ oversampled analog-to-digital converter (ADC) implemented with switched-capacitor circuits, and a dedicated digital demodulator with a 32-bit wordlength. The outputs from the ADCs are processed by digital processors. The digital demodulator uses a novel adaptive AM demodulation algorithm based on prediction techniques. A bit-serial silicon compiler is used to complete the design. The design was fabricated in a 1.2-μm bulk CMOS process and contains 85000 transistors in a die size of 325×330 mils <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Test results show that absolute accuracies of ±0.2% were achieved without the need for calibration