gebhart/patrepeval huggingface dataset:
Alterations of human acellular tissue matrix by gamma irradiation: Histology, biomechanical property, stability, in vitro cell repopulation, and remodeling (2007)

AlloDerm, a processed acellular human tissue matrix, is used in a number of surgical applications for tissue repair and regeneration. In the present work, AlloDerm serves as a model system for studying gamma radiation-induced changes in tissue structure and stability as well as the effect of such changes on the cell-matrix interactions, including cell repopulation and matrix remodeling. AlloDerm tissue matrix was treated with 2-30 kGy gamma irradiation at room temperature. Gamma irradiation reduced the swelling of tissue matrix upon rehydration and caused significant structural modifications, including collagen condensation and hole formation in collagen fibres. The tensile strength of AlloDerm increased at low gamma dose but decreased with increasing gamma dosage. The elasticity of irradiated AlloDerm was reduced significantly. Calorimetric study showed that gamma irradiation destabilized the tissue matrix, resulting in greater susceptibility to proteolytic enzyme degradation. Although gamma irradiation did not affect in vitro proliferation of fibroblast cells, it promoted tissue degradation upon cell repopulation and influenced synthesis and deposition of new collagen.
Investigation of Turbo Machinery and Jet Noise of the V2500 Engine During Ground Tests with an A320 Aircraft (2015)

The noise emission of a V2500 engine during ground operation was investigated with the A320 research aircraft ATRA of the German aerospace center DLR. Acoustic measurements with a microphone array parallel to the engine shaft axis were performed with the engines running at different speeds between idle and maximum continuous thrust. The main measurements took place in a noise-protection hangar, because optical measurents with laser devices were performed in parallel. In order to assess the impact of the room acoustics on the sound field, reference measurements were performed under free-field conditions, using the same microphone array set up on the ground. The array data were analysed using classical spectral methods and the SODIX (source directivity modelling in the cross-spectral matrix) method. SODIX fits equivalent source distributions, for different frequency bands and emission directions, to the measured cross-spectral matrices. The results show sources at the engine inlet, nozzle and along the jet. When the spectra and source distributions from the main measurements in the hangar are compared to the free-field data, the deviations are acceptable. This confirms that this type of noise protection hangar is a suitable environment to perform acoustic measurements of aircraft engines.
Activity and Persistence of Synthetic and Natural Sex Attractants of the Gypsy Moth in Laboratory and Field Trials1 (1971)

The sex attractant emitted by virgin female Porthetria Dispar (L.) to attract the male moth for mating has been identified and synthesized recently. This compound, disparlure, has been found active, and when suitably formulated, levels as low as 0.001 μg/trap are active even after 3 months aging in the field. Activity of disparlure is extended by combining it with volatile or nonvolatile keepers. Trioctanoin is a satisfactory keeper of the nonvolatile type, and formulations with it, e.g. 5 mg with 1 μg disparlure, are highly effective for at least 3 months and are far more attractive and persistent in survey traps than the presently used extracts of virgin females. Triolein and 2 other unsaturated compounds appear to degrade disparlure, especially low lure concentrations. Several keepers of the volatile type provide good activity hut are not so suitable for use in survey traps. Volatility of disparlure lies between the volatilities of methyl palmitate and 1,2-epoxyoctadecane. Effects of factors such as lure concentrations, configuration of the epoxide, keepers and keeper concentration, aging of disparlure formulations, trap capacity, and degree of insect infestation on moth captures are discussed. Disparlure did not become repellent at levels up to 1000 μg /trap. With light infestations of the moth, log-log plots of trap captures vs. concentration of attractant per trap were linear. An ether related to disparlure was synthesized and was slightly active. Cis and trans gyptol and gyplure and ricinoleyl alcohol were purified, and the pure compounds and impurities were tested; some of the materials are slightly active. None of the tested compounds or impurities masked the activity of disparlure significantly. The natural extract was studied also. After epoxidation, the hydrocarbon fraction of the natural extract of female tips was very active and persistent when mixed with trioctanoin. Addition of natural tip extract to disparlure depressed catches.
Domain Adaptive Multibranch Networks (2020)

We tackle unsupervised domain adaptation by accounting for the fact that different domains may need to be processed differently to arrive to a common feature representation effective for recognition. To this end, we introduce a deep learning framework where each domain undergoes a different sequence of operations, allowing some, possibly more complex, domains to go through more computations than others. This contrasts with state-of-the-art domain adaptation techniques that force all domains to be processed with the same series of operations, even when using multi-stream architectures whose parameters are not shared. As evidenced by our experiments, the greater flexibility of our method translates to higher accuracy. Furthermore, it allows us to handle any number of domains simultaneously.
Integrating Blockchain, Smart Contract-Tokens, and IoT to Design a Food Traceability Solution (2018)

Information asymmetry exists amongst stakeholders in the current food supply chain. Lack of standardization in data format, lack of regulations, and siloed, legacy information systems exasperate the problem. Global agriculture trade is increasing creating a greater need for traceability in the global supply chain. This paper introduces Harvest Network, a theoretical end-to-end, vis a vie “farm-to-fork”, food traceability application integrating the Ethereum blockchain and IoT devices exchanging GS1 message standards. The goal is to create a distributed ledger accessible for all stakeholders in the supply chain. Our design effort creates a basic framework (artefact) for building a prototype or simulation using existing technologies and protocols [1]. The next step is for industry practitioners and researchers to apply AGILE methods for creating working prototypes and advanced projects that bring about greater transparency.
Cytotoxicity of AH Plus and AH26 in vitro on Chinese hamster V79 fibroblasts (2000)

The purpose of the study was to evaluate cytotoxicity of AH Plus, compared to AH26 in vitro on Chinese hamsters V79 fibroblasts. The materials were prepared according to the manufacturer's instructions. After the initial setting period, the materials were crumbled and dissolved in dimetil-sulfoxide solution. The extracts obtained were incubated at 37C during one hour, 24 hours and 7 days. After incubation period the samples were diluted with Eagle’s minimum essential medium to concentrations ranging from 1.67 μg/ml to 167 μg/ml. Each concentration was placed on a plate with 24 wells with 5x103 V79 cells per 1.2 ml of medium. The number of cells was counted by electronic counter and the percentage of viable cells was determined by a light microscope. Both materials, AH26 and AH Plus were found to be cytotoxic. In both materials cytotoxic effect was related to the concentration of endodontic sealer in the extract solution. The critical concentrations, above which the sealers totally destroy the cell line are between 5.57 μg/ml and 167 μg/ml for AH Plus and 16.57 μg/ml and 167 μg/ml for AH26. The setting time did not have a statistically significant effect an cytotoxicity.
Flash co-pyrolysis of biomass with biopolymers: a preliminary evaluation (2007)

The influence of biopolymers on the pyrolysis yields is investigated using a semi-continuoushome-built pyrolysis reactor. All biopolymers show their specific benefits during the overallco-pyrolysis process. In a first attempt, each pyrolysis (pure willow and all I: I w/w ratiowillow/biopolymer blends) is evaluated based on nine objectives. Afterwards, ThomasSaaty's Analytic Hierarchy Process is used in order to obtain an objective ranking of thedifferent biopolymer options. The flash co-pyrolysis of I: I willow/PHB(Polyhydroxybutyrate) is the most performant option, while I: I willow/PLA (Polylactic acid),I:I willow/Biopearls and I: I willow/Potato starch show increased potential as well. The factthat biopolymers, despite their biodegradability, are considered as waste makes the flash copyrolysis of willow and biopolymers an additional necessity.
Corrosion and Hydrate Control in Wet Sour Gas Transmission Systems (2008)

Abstract Generally, the most economical material for construction in oil and gas pipeline systems is carbon steel. Besides the safety and environmental issues, downtime caused by corrosion related failures and hydrate-induced blockages in pipelines can be costly to the operator. Asset integrity and flow assurance are, therefore, recognised to be critical issues in oil and gas production and transportation. Chemical inhibitors to protect pipelines from metal degradation and hydrate blockages are commonly utilised but compatible corrosion inhibitor (CI) and kinetic hydrate inhibitor (KHI) combinations are often difficult to formulate for sour gas applications. It is often found that either the KHI has an adverse affect on the CI function or vice versa. Before field deployment, extensive inhibitor testing and evaluation is conducted to ensure that the most appropriate products are selected. This paper presents data from a laboratory programme which was instigated to develop and assess new corrosion inhibitor formulations. Performance was evaluated in terms of the corrosion inhibition of the CI and its KHI compatibility and performance in supplementary secondary property tests under simulated sour gas pipeline operating conditions. From this work two CI/KHI combinations exhibiting excellent compatibility in terms of corrosion inhibition performance (both general corrosion inhibition as well as, more importantly, pitting corrosion inhibition), hydrate inhibition performance and high temperature injection performance have been developed.
Effect of an automated, nursing unit-based drug-dispensing device on medication errors (1995)

The effect of an automated drug-dispensing system on medication error rates was studied. Disguised observations were made on nursing units just before (phase 1) and two months after (phase 2) the implementation of Medstation Rx (Pyxis, San Diego, CA) at a 600-bed hospital. Information gathered included the time of drug administration, the time the medication as ordered to be given, a description of what happened during administration of the dose, and the type of medication error, if any. During phase 1 there were 873 observations and 148 medication errors, for an error rate of 16.9%. During phase 2 the error rate was 10.4% (97 errors in 929 observations). In both study phases, most of the errors were wrong-time errors. The mean +/- S.D. difference between actual and scheduled administration times was 34.5 +/- 48.9 minutes in phase 1 and 30.1 +/- 31.6 minutes in phase 2. Both the decrease in the error rate and the decrease in the departure from scheduled administration times were statistically significant. Medstation Rx was associated with a reduction in the rate of medication errors at a large hospital.
SUPPRESSION OF THE THYROTROPHIN CIRCADIAN RHYTHM BY GLUCOCORTICOIDS (1974)

Pharmacological doses of glucocorticoids inhibit thyroid function in man and laboratory animals due to suppression of thyrotrophin (TSH) secretion (Wilber & Utiger, 1969). Administration of prednisolone or dexamethasone for 1–2 days results in a suppression of basal serum TSH levels in normal subjects and in patients with primary hypothyroidism, whilst the pituitary TSH reserve capacity, as assessed by the response to synthetic thyrotrophin releasing hormone (TRH), remains unaltered (Wilber & Utiger, 1969; Besser, Ratcliffe, Kilborn, Ormston & Hall, 1971; Haigler, Pittman & Hershman, 1971). However, impairment of serum TSH response to administered TRH does occur in patients treated with glucocorticoids for 1 or more months (Otsuki, Dakoda & Baba, 1973). These studies suggest that glucocorticoids may inhibit TSH secretion at both hypothalamic and pituitary levels but the main effect of the short-term treatment is suppression of TRH production. Nicoloff, Fisher & Appleman (1970) found that the circadian rhythm of thyroidal
Valeur et portée des validations législatives devant le juge constitutionnel : un nouvel équilibre entre les considérations liées à l'intérêt général et celles relatives à la garantie des droits ? (1998)

International audience
Digital image warping : theory and real time hardware implementation issues (1996)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
Structures of the Steroidal Alkaloids 25-Isosolafloridine and Solacallinidine Isolated From Solanum callium (1979)

The two major alkaloids isolated from Solanum callium are 25-isosolafloridine and solacallinidine, which have the structures (25 S )-22,26-epimino-5a-cholest-22(N)-ene-3ß,16a -diol (la) and (25s)- 3~-amino-22,26-epimino-5a -cholest-22(N)-en-l6a -o1 (lla), respectively. The somewhat different properties reported by previous workers for a synthetic compound described as 25-isosolafloridine indicate that it was probably not stereoisomerically pure.
Ring-size effects in the reaction of benzocycloalkadiene epoxides with lithium diisopropylamide (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing-size effects in the reaction of benzocycloalkadiene epoxides with lithium diisopropylamideRichard W. Thies and Ronald H. ChiarelloCite this: J. Org. Chem. 1979, 44, 8, 1342–1344Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/jo01322a033https://doi.org/10.1021/jo01322a033research-articleACS PublicationsRequest reuse permissionsArticle Views275Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Fig. 1 from Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab (2023)

&lt;p&gt;Frequencies and NO production by moMDSCs from non-responders (A) and responders (B) after the first infusion of ipilimumab.&lt;/p&gt;
Automatic image segmentation and classification using on-line shape learning (2002)

The detection, precise segmentation and classification of specific objects is an important task in many computer vision and image analysis problems, particularly in medical domains. Existing methods such as template matching typically require excessive computation and user interaction, particularly if the desired objects have a variety of different shapes. This paper presents a new approach that uses unsupervised learning to find a set of templates specific to the objects being outlined by the user. The templates are formed by averaging the shapes that belong to a particular cluster, and are used to guide an intelligent search through the space of possible objects. This results in decreased time and increased accuracy for repetitive segmentation problems, as system performance improves with continued use. Further, the information gained through clustering and user feedback is used to classify the objects for problems in which shape is relevant to the classification. The effectiveness of the resulting system is demonstrated on two applications: a medical diagnosis task using cytological images and a vehicle recognition task.
Isothermal vapor-phase epitaxy of Hg1−xCdxTe on CdTe and Al2O3 substrates (1985)

The isothermal vapor-phase-epitaxial (ISOVPE) growth of device-quality HgCdTe layers on both CdTe and CdTe/Al2O3 substrates has been demonstrated. The material and device properties on both types of substrates have been studied and compared with reported values for HgCdTe grown by other techniques. The as-grown ISOVPE Hg1−xCdxTe (x≂0.3) epilayers are always p type with carrier concentrations of ∼5×1015 to 3×1016 cm−3 and mobilities of ∼230–260 cm2/V s at 77 K. The temperature and compositional dependence of electrical properties of ISOVPE Hg1−xCdxTe are somewhat different from those of liquid-phase epitaxy (LPE) and bulk HgCdTe. In particular, the acceptor ionization energy, EA =7 meV, is about half that obtained in midwavelength infrared LPE or bulk HgCdTe, and nearly independent of composition x. The R0A product of a representative photodiode (λc ≂4.65 μm, 77 K) is 2×106 and 4 Ω cm2 at 77 and 195 K, respectively, with comparable device qualities seen on both CdTe and CdTe/Al2O3 substrates.
Synthesis and juvenile hormone activities of some new ether derivatives of hydroquinone (1983)

Abstract A new class of compounds, derived from hydroquinones, has been synthesised and bioassayed for juvenile hormone activity on yellow mealworm ( Tenebrio molitor ), confused flour beetle ( Tribolium confusum ), and mediterranean flour moth ( Anagasta kuehniella ). Structure‐biological activity relationships of the most significant products are tabulated and discussed. Two of the new compounds, 1, 4‐bis(5‐chloropent‐4‐ynyloxy) benzene (I) and 1‐(5‐chloropent‐4‐ynyloxy)‐4‐phenoxybenzene (II), showed outstanding activity in morphogenetic assay with T. molitor , and good field persistence. Product II is of particular interest for the control of various Homopteran species, mosquitoes, stored product pests and fire ants.
Imaging of Hafnium Atoms and Clusters in Silicon Dioxide (2006)

Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2006
Protein Kinase D Intracellular Localization and Activity Control Kinase D-interacting Substrate of 220-kDa Traffic through a Postsynaptic Density-95/Discs Large/Zonula Occludens-1-binding Motif (2006)

Protein kinase D (PKD) controls protein traffic from the trans-Golgi network (TGN) to the plasma membrane of epithelial cells in an isoform-specific manner. However, whether the different PKD isoforms could be selectively regulating the traffic of their specific substrates remains unexplored. We identified the C terminus of the different PKDs that constitutes a postsynaptic density-95/discs large/zonula occludens-1 (PDZ)-binding motif in PKD1 and PKD2, but not in PKD3, to be responsible for the differential control of kinase D-interacting substrate of 220-kDa (Kidins220) surface localization, a neural membrane protein identified as the first substrate of PKD1. A kinase-inactive mutant of PKD3 is only able to alter the localization of Kidins220 at the plasma membrane when its C terminus has been substituted by the PDZ-binding motif of PKD1 or PKD2. This isoform-specific regulation of Kidins220 transport might not be due to differences among kinase activity or substrate selectivity of the PKD isoenzymes but more to the adaptors bound to their unique C terminus. Furthermore, by mutating the autophosphorylation site Ser916, located at the critical position -2 of the PDZ-binding domain within PKD1, or by phorbol ester stimulation, we demonstrate that the phosphorylation of this residue is crucial for Kidins220-regulated transport. We also discovered that Ser916 trans-phosphorylation takes place among PKD1 molecules. Finally, we demonstrate that PKD1 association to intracellular membranes is critical to control Kidins220 traffic. Our findings reveal the molecular mechanism by which PKD localization and activity control the traffic of Kidins220, most likely by modulating the recruitment of PDZ proteins in an isoform-specific and phosphorylation-dependent manner. © 2006 by The American Society for Biochemistry and Molecular Biology, Inc.
A multisensor robotic module interchange system for space maintenance (2003)

The authors show the feasibility of realistic autonomous space manipulation tasks using multisensory information from a vision, force/torque, and touch sensor. They describe the basic functions of the robotic system including the design, implementation, and integration of each of the sensors mentioned above. The cooperative use of sensors is shown through mating/demating of a module interchange system. Autonomous location of the mating element, autonomous location of a guiding light target, mating and demating of the system are successfully performed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19 (2021)

The coronavirus disease 2019 (COVID-19) pandemic caused by the emergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public health, and there is an urgent need to develop safe and effective vaccines. Here, we report the generation and the preclinical evaluation of a novel replication-defective gorilla adenovirus-vectored vaccine encoding the pre-fusion stabilized Spike (S) protein of SARS-CoV-2. We show that our vaccine candidate, GRAd-COV2, is highly immunogenic both in mice and macaques, eliciting both functional antibodies that neutralize SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and a robust, T helper (Th)1-dominated cellular response. We show here that the pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies. To face the unprecedented need for vaccine manufacturing at a massive scale, different GRAd genome deletions were compared to select the vector backbone showing the highest productivity in stirred tank bioreactors. This preliminary dataset identified GRAd-COV2 as a potential COVID-19 vaccine candidate, supporting the translation of the GRAd-COV2 vaccine in a currently ongoing phase I clinical trial (ClinicalTrials.gov: NCT04528641).
Dynamic Contrast Enhancement (2009)

The aim of this chapter is to provide an overview about models and methodologies used for the Dynamic Contrast Enhancement (DCE) analysis. DCE is a non-invasive methodology aimed to diagnostic the nature of a lesion on the base of the perfusion’s dynamic of specific contrast agents. The idea at the base of DCE is that, in several pathological tissues, including tumors and inflammatory diseases, the angiogenic process is abnormal, hence the characterization of vascularisation structure may be used to support the diagnosis. In this chapter, we will describe the basic DCE procedures and introduce some of its most innovative evolution based on the pharmacokinetic analysis technique (PK), and the empirical model (EM). Even if DCE is still a medical research topic, there is large interest for this type of approach in biomedical applications as witnessed by the availability of specific tools in the last generation top-class US, CT and MR machines.