gebhart/patrepeval huggingface dataset:
Managing organizational change: strategies for the female health care supervisor. (1990)

In responding to resistance to change in the current health care organization, the new female supervisor can learn to support her staff in encountering and accepting these changes. The strategies and skills discussed above are characteristic of a supervisory style that may naturally occur for women, but also can be incorporated into the leadership style of men in health care management today. Health care leaders of tomorrow must work from an androgynous framework in which the behavior patterns and responses of each gender are learned and used appropriately by both men and women. Sargent suggests that the best managers are androgynous and that this is the inevitable wave of the future. Whether man or woman, a supervisor should learn, accept, and use methods that are characteristic of both sexes to be successful in managing people. Women and men must learn from each other's strengths and share these diverse skills. Given that women now outnumber men in health care management positions and organizations are changing to a more nurturing environment, the androgynous supervisor will be the successful leader of the future. Finally, women in health care supervisory positions have the potential to bring change where it is badly needed. Women in these roles often have a system wide view of health care policy issues that recognizes less federal commitment to social programs. Many women in health care positions believe that the issues of children, women, the elderly, the poor, and the homeless need focused attention. The growing number of women in health care supervisory and leadership roles is an important factor in changing national health policy for the benefit of these groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Finding interesting associations without support pruning (2002)

Association rule mining has heretofore relied on the condition of high support to do its work efficiently. In particular, the well-known a-priori algorithm is only effective when the only rules of interest are relationships that occur very frequently. However, there are a number of applications, such as data mining, identification of similar Web documents, clustering and collaborative filtering, where the rules of interest have comparatively few instances in the data. In these cases, we must look for highly correlated items, or possibly even causal relationships between infrequent items. We develop a family of algorithms for solving this problem, employing a combination of random sampling and hashing techniques. We provide an analysis of the algorithms developed and conduct experiments on real and synthetic data to obtain a comparative performance analysis.
The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis (2007)

The TAF4 subunit of transcription factor TFIID was inactivated in the basal keratinocytes of foetal and adult mouse epidermis. Loss of TAF4 in the foetal epidermis results in reduced expression of the genes required for skin barrier function, leading to early neonatal death. By contrast, TAF4 inactivation in adult epidermis leads to extensive fur loss and an aberrant hair cycle characterised by a defective anagen phase. Although the mutant epidermis contains few normal anagen-phase hair follicles, many genes expressed at this stage are strongly upregulated indicating desynchronized and inappropriate gene expression. The TAF4 mutant adult epidermis also displays interfollicular hyperplasia associated with a potent upregulation of several members of the EGF family of mitogens. Moreover, loss of TAF4 leads to malignant transformation of chemically induced papillomas and the appearance of invasive melanocytic tumours. Together, our results show that TAF4 is an important regulator of keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity.
Four-dimensional optical multiband-OFDM for beyond 14 Tb/s serial optical transmission (2011)

We propose a four-dimensional (4D) coded multiband-OFDM scheme suitable for beyond 1.4 Tb/s serial optical transport. The proposed scheme organizes the N-dimensional (ND) signal constellation points in the form of signal matrix; employs 2D-inverse FFT and 2D-FFT to perform modulation and demodulation, respectively; and exploits both orthogonal polarizations. This scheme can fully exploit advantages of OFDM to deal with chromatic dispersion, PMD and PDL effects; and multidimensional signal constellations to improve OSNR sensitivity of conventional optical OFDM. The improvement of 4D-OFDM over corresponding polarization-multiplexed QAM (with the same number of constellation points) ranges from 1.79 dB for 16 signal constellation point-four-dimensional-OFDM (16-4D-OFDM) up to 4.53 dB for 128-4D-OFDM.
Modeling bioterrorism preparedness with simulation in rural healthcare system (2007)

As a result of the anthrax letter incidents in 2001, concerns about terrorists' use of biological agents have increased dramatically at government state and federal levels. The problem of providing sufficient resources in a healthcare system during a widespread bioterrorist attack is important issues all hospitals encounter. The innovative computer simulation models of the overall treatment process at Lub-bock area healthcare systems were developed using the professional simulation software Flexsim 2.6 to determine the total time patient stays in the system and to identify the staff requirement in order to avoid delays in treatment for a variety of hypothetical bioterrorist attack scenarios.
Real-time synchronous measurement of curing characteristics and polymerization stress in bone cements with a cantilever-beam based instrument (2018)

An instrumentation capable of simultaneously determining degree of conversion (DC), polymerization stress (PS), and polymerization exotherm (PE) in real time was introduced to self-curing bone cements. This comprises the combination of an in situ high-speed near-infrared spectrometer, a cantilever-beam instrument with compliance-variable feature, and a microprobe thermocouple. Two polymethylmethacrylate-based commercial bone cements, containing essentially the same raw materials but differ in their viscosity for orthopedic applications, were used to demonstrate the applicability of the instrumentation. The results show that for both the cements studied the final DC was marginally different, the final PS was different at the low compliance, the peak of the PE was similar, and their polymerization rates were significantly different. Systematic variation of instrumental compliance for testing reveals differences in the characteristics of PS profiles of both the cements. This emphasizes the importance of instrumental compliance in obtaining an accurate understanding of PS evaluation. Finally, the key advantage for the simultaneous measurements is that these polymerization properties can be correlated directly, thus providing higher measurement confidence and enables a more in-depth understanding of the network formation process.
Mouse Dipeptidyl Peptidase 4 Is Not a Functional Receptor for Middle East Respiratory Syndrome Coronavirus Infection (2014)

Human dipeptidyl peptidase 4 (hDPP4) was recently identified as the receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) infection, suggesting that other mammalian DPP4 orthologs may also support infection. We demonstrate that mouse DPP4 cannot support MERS-CoV infection. However, employing mouse DPP4 as a scaffold, we identified two critical amino acids (A288L and T330R) that regulate species specificity in the mouse. This knowledge can support the rational design of a mouse-adapted MERS-CoV for rapid assessment of therapeutics.
Absorption detection in microcolumn liquid chromatography via indirect polarimetry (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAbsorption detection in microcolumn liquid chromatography via indirect polarimetryDonald R. Bobbitt and Edward S. YeungCite this: Anal. Chem. 1985, 57, 1, 271–274Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/ac00279a062https://doi.org/10.1021/ac00279a062research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CD44 cell adhesion molecules. (1999)

The CD44 proteins form a ubiquitously expressed family of cell surface adhesion molecules involved in cell-cell and cell-matrix interactions. The multiple protein isoforms are encoded by a single gene by alternative splicing and are further modified by a range of post-translational modifications. CD44 proteins are single chain molecules comprising an N-terminal extracellular domain, a membrane proximal region, a transmembrane domain, and a cytoplasmic tail. The CD44 gene has only been detected in higher organisms and the amino acid sequence of most of the molecule is highly conserved between mammalian species. The principal ligand of CD44 is hyaluronic acid, an integral component of the extracellular matrix. Other CD44 ligands include osteopontin, serglycin, collagens, fibronectin, and laminin. The major physiological role of CD44 is to maintain organ and tissue structure via cell-cell and cell-matrix adhesion, but certain variant isoforms can also mediate lymphocyte activation and homing, and the presentation of chemical factors and hormones. Increased interest has been directed at the characterisation of this molecule since it was observed that expression of multiple CD44 isoforms is greatly upregulated in neoplasia. CD44, particularly its variants, may be useful as a diagnostic or prognostic marker of malignancy and, in at least some human cancers, it may be a potential target for cancer therapy. This review describes the structure of the CD44 gene and discusses some of its roles in physiological and pathological processes.
Additive diagnostic value of atherosclerotic plaque characteristics to non-invasive FFR for identification of lesions causing ischemia: results from a prospective international multicenter trial (2013)

Purpose: Non-invasive fractional flow reserve derived from coronary CT angiography (FFRCT) is a novel method for diagnosis of ischemic coronary lesions. Adverse plaque characteristics (APC) by coronary CT angiography (CT)–including positive remodeling (PR), low attenuation plaque (LAP) and spotty calcification (SC)–are associated with myocardial ischemia. To date, whether APCs offer additive value to FFRCT for identifying ischemia-causing lesions remains unknown. Methods: 252 patients at 17 centers in 5 countries were enrolled in the DeFACTO (Diagnostic Accuracy of Fractional Flow Reserve From Anatomic CT Angiography) study. Patients underwent CT, FFRCT, invasive coronary angiography and clinically indicated FFR in 407 lesions. FFRCT, FFR and CT were interpreted by independent core laboratories. Invasive FFR ≤0.80 was diagnostic of lesion-specific ischemia, while CT stenosis ≥70% was considered obstructive. APCs within coronary lesions by CT were defined as: (1) PR, remodeling index >1.10; (2) LAP, any voxel <30 HU; and (3) SC, nodular calcium <3 mm. Discrimination of lesion-specific ischemia was evaluated by areas under the receiver-operating-characteristics curve (AUC). Results: By FFR, ischemia was identified in 151 of 407 lesions (37%), and by CT, obstructive stenoses were identified in 166 (41%) lesions. The presence of any APC was detected in 209 (51%), with PR, LAP and SC observed in 193 (47%), 90 (22%), and 68 (17%) lesions, respectively. The discriminatory power to identify ischemia-causing lesions was 0.73 for CT stenosis alone, 0.84 for FFRCT and 0.87 for FFRCT plus all 3 APCs (p<0.01 compared to FFRCT and CT stenosis alone for both) [Figure]. ROC curves for lesion-specific ischemia ROC curves for lesion-specific ischemia Conclusions: APCs improve discrimination of ischemia-causing lesions beyond FFRCT and CT stenosis alone.
Granular stochastic modeling of robot micrometric precision (2011)

The paper aims at modeling and quantifying robot precision when it is possible to obtain information from external sensors in the operating area. The author proves that in this situation, neither the pose repeatability, nor the pose accuracy are adequate to calculate the maximum position error. A new paradigm is then proposed: granulous space modeling which combines spatial resolution and actuators' repeatability. This stochastic modeling is first detailed in unidimensional space then in the case of bidimensional space. The methodology to compute the maximal position error is given and compared with other approaches.
Efficient, Scalable Congestion Management for Interconnection Networks (2006)

Compared to the overdimensioned designs of the past, current interconnection networks operate closer to the point of saturation and run a higher risk of congestion. Among proposed strategies for congestion management, only the regional explicit congestion notification (RECN) mechanism achieves both the required efficiency and the scalability that emerging systems demand
Homogeneous Charge Combustion and Emissions of Ethanol Ignited by Pilot Diesel on Diesel Engines (2004)

&lt;div class="htmlview paragraph"&gt;Homogeneous charge combustion and emissions of ethanol ignited by pilot diesel fuel were investigated on a two-cylinder diesel engine. The results show that emissions depend on loads and ethanol volume fraction. At low loads, ethanol has little effects on smoke. With the increase of ethanol, NOx decreases, but CO emissions increase. At high loads, smoke emissions reduce greatly with increasing ethanol, but NOx and total hydrocarbon (THC) emissions increase.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;With the increase of ethanol, ignition delays, combustion duration shortens. The maximum rates of heat release for the fuel containing 10 vol% ethanol (E10) and 30 vol% ethanol (E30) increase. Brake specific energy consumption (BSEC) of E10 and E30 is improved slightly only at full loads.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Compared to smoke emissions obtained on the same engine using ethanol blended diesel fuels, the tendency of smoke reduction is similar to that of homogeneous charge combustion of ethanol at the same operating conditions. But the former is more effective in reducing smoke emissions.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;When the engine operated at high constant loads, smoke significantly decreases with increasing ethanol and smokeless combustion can be achieved at certain ethanol volume fraction dependent on loads. In the meantime, THC emissions gradually increase. Ignition retards, peak pressure increases first and then decreases again. Indicated mean effective pressures are close to those of diesel (E0), even higher than the latter at some cases. NOx emissions are dependent on loads and ethanol volume fraction, and even are less than those of E0 under certain conditions.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The results obtained from an optical diesel engine show that ethanol also shortens combustion duration, decreases flame temperature and KL factor, which indicates that ethanol can suppress soot formation in combustion chamber.&lt;/div&gt;
Simulation Models of Sequences of Dry and Wet Days (1989)

A new statistical model has been developed for the simulation of sequences of dry and wet days. The model is based on the discrete autoregressivemoving average (DARMA) family of stochastic processes, which includes the Markov chain as a particular case. The model building is based on a three‐step procedure consisting of identification, estimation, and model selection. The model identification and parameter estimation are based on the best fit of the autocorrelation function, while the selection of the optimum model is based on the best reproduction of the probability distribution function of the lengths of the runs of dry days and wet days. The model has thus the property of reproducing the persistence of dry spells and wet spells which are important in the evaluation and forecast of droughts and floods. Excellent results were obtained with rainfall data from Indiana, which indicate that the models are useful for scheduling irrigation of crops in the Central United States and possibly elsewhere.
ChemInform Abstract: SYNTHESIS OF OPTICALLY ACTIVE NICOTINOIDS (1982)

Abstract Aus L‐Prolin (Ia) erhält man nach Reduktion zum Prolinol (Ib) bei der Metliyliertlng das N‐Metliylderivat (II), das auch aus (I21) durch N‐Formylierung und Alanat‐Reduktion erhalten werden kann.
Systematic Review of Clinical Studies Examining Biomarkers of Brain Injury in Athletes after Sports-Related Concussion (2014)

The aim of this study was to systematically review clinical studies examining biofluid biomarkers of brain injury for concussion in athletes. Data sources included PubMed, MEDLINE, and the Cochrane Database from 1966 to October 2013. Studies were included if they recruited athletes participating in organized sports who experienced concussion or head injury during a sports-related activity and had brain injury biomarkers measured. Acceptable research designs included experimental, observational, and case-control studies. Review articles, opinion papers, and editorials were excluded. After title and abstract screening of potential articles, full texts were independently reviewed to identify articles that met inclusion criteria. A composite evidentiary table was then constructed and documented the study title, design, population, methods, sample size, outcome measures, and results. The search identified 52 publications, of which 13 were selected and critically reviewed. All of the included studies were prospective and were published either in or after the year 2000. Sports included boxing (six studies), soccer (five studies), running/jogging (two studies), hockey (one study), basketball (one study), cycling (one study), and swimming (one study). The majority of studies (92%) had fewer than 100 patients. Three studies (23%) evaluated biomarkers in cerebrospinal fluid (CSF), one in both serum and CSF, and 10 (77%) in serum exclusively. There were 11 different biomarkers assessed, including S100β, glial fibrillary acidic protein, neuron-specific enolase, tau, neurofilament light protein, amyloid beta, brain-derived neurotrophic factor, creatine kinase and heart-type fatty acid binding protein, prolactin, cortisol, and albumin. A handful of biomarkers showed a correlation with number of hits to the head (soccer), acceleration/deceleration forces (jumps, collisions, and falls), postconcussive symptoms, trauma to the body versus the head, and dynamics of different sports. Although there are no validated biomarkers for concussion as yet, there is potential for biomarkers to provide diagnostic, prognostic, and monitoring information postinjury. They could also be combined with neuroimaging to assess injury evolution and recovery.
Anomalous Scattering in Superconducting Indium-Doped Tin Telluride (2010)

Results of resistivity, Hall effect, magnetoresistance, susceptibility and heat capacity measurements are presented for single crystals of indium-doped tin telluride with compositions Sn$_{.988-x}$In$_x$Te where $0 \leq x \leq 8.4 %$, along with microstructural analysis based on transmission electron microscopy. For small indium concentrations, $x \leq 0.9 %$ the material does not superconduct above 0.3 K, and the transport properties are consistent with simple metallic behavior. For $x \geq 2.7 %$ the material exhibits anomalous low temperature scattering and for $x \geq 6.1 %$ bulk superconductivity is observed with critical temperatures close to 2 K. Intermediate indium concentrations $2.7% \leq x \leq 3.8%$ do not exhibit bulk superconductivity above 0.7 K. Susceptibility data indicate the absence of magnetic impurities, while magnetoresistance data are inconsistent with localization effects, leading to the conclusion that indium-doped SnTe is a candidate charge Kondo system, similar to thallium-doped PbTe.
Heterolytic CH Activation with a Cyclometalated Platinum(II) 6-Phenyl-4,4‘-di-tert-butyl-2,2-Bipyridine Complex (2006)

The more electron-rich, thermally, air, and protic stable, cyclometalated Pt(II)(NNC) trifluoroacetate complex (3) (NNC = κ3-6-phenyl-4,4‘-di-tert-butyl-2,2‘-bipyridine) was synthesized with the expectation that it would be less susceptible to H2O inhibition than the Pt(bpym)(TFA)2 system (bpym = κ2-2,2‘-bipyrimidine) for the catalytic oxidation of hydrocarbons. Complex 3 was found to catalyze the H/D exchange between benzene and trifluoroacetic acid via CH activation but at a rate slower than the Pt(bpym) complex. Experimental and theoretical studies show that while the use of the more electron-rich NNC ligand motif lowered the ΔH for substrate coordination relative to the Pt(bpym) system, a larger increase in the barrier for CH cleavage led to an increase in the overall barrier for CH activation.