gebhart/patrepeval huggingface dataset:
JS1.3 Autoimmune encephalitis as immune related adverse event (irAE) of check point inhibitors (CPI) not so rare as we thought (2019)

Abstract INTRODUCTION CPI has significant efficacy and toxicities. We describe our experience with CPI treated patients diagnosed with irAE encephalitis. METHODS Patients treated with CPI during 2017–2018 were identified from institute’s EMR. Patients treated for irAE encephalitis were identified from the database of the Neuro-Oncology Unit of the Institute. Results: Eleven patients were diagnosed with irAE encephalitis out of 1500 treated with CPI at the Institute (0.73%). Four patients had NSCLC, 3 had melanoma, the one patient had each of SCLC, uterine carcinoma, RCC and breast cancer. Median age was 69 years (49–87). Four of 11 were treated with chemo-CPI, 3-with CPI combinations. Median onset of symptoms was at 19 days (5–180) following initial treatment. All events were high grade severity. Eight patients fully recovered after immunotherapy discontinuation and steroid treatment, of these, 2 melanoma patients underwent uncomplicated CPI re-challenge. Three patients, all non-melanoma, had severe neurological sequelae. Two of them were treated with steroids, PLEX and cyclophosphamide: one improved neurologically although died 6 months later from cancer. One patient was oncologically stable but died from neurological deterioration 7 months later. The additional patient was treated with steroids only because his advanced age and decease in hospice 2 months later. CONCLUSION Encephalitis, as an irAE of CPI, seems to be more common and severe than previously thought, predominantly in non melanoma patients. Nevertheless, in the majority of cases it is reversible and in some melanoma patients immunotherapy re-challenge is safe. Future studies will have to define risk factors and severity prediction.
$\mu $ MPI—Initial Experiments With an Ultrahigh Resolution MPI (2015)

Magnetic particle imaging (MPI) is a novel imaging method for the depiction of superparamagnetic materials. Since the first publication several MPI scanner were presented, which work at gradient strength of ~2-7 T/m. This is reasonable for in vivo imaging and provides a resolution of ~1 mm. In this paper, several approaches for a micro-MPI (μMPI) device for very small samples are presented, which works at a very high magnetic gradient strength of ~85 T/m. This results in a theoretical resolution <;100 μm. This μMPI device can be operated at several modes, which have different advantages. In preliminary tests, the feasibility of the μMPI device has been proven.
LED to LEC Transition Behavior in Polymer Light‐Emitting Devices (2008)

LED to LEC transition behavior is demonstrated in polymer hybrid light-emitting devices. By utilizing both mobile ions in the polymer layer and a low-work-function cathode for electron injection, we observe and investigate the transition from LED to LEC behavior. These hybrid light-emitting devices demonstrate fast turn-on, low operating voltage, high brightness, and long operating lifetime.
Anti-phosphohistone H3 as an independent prognostic factor in human esophageal squamous cell carcinoma. (2013)

The expression of PHH3 impacts the prognosis of patients with ESCC.
Microseisms in geothermal exploration; studies in Grass Valley, Nevada (1979)

Abstract Frequency(f)-wavenumber(k) spectra of seismic noise in the bands 1 &amp;lt; or = f &amp;lt; or = 10 Hz in frequency and k &amp;lt; or = 35.7 cycles/km in wavenumber, measured at several places in Grass Valley, Nevada, exhibit numerous features which can be correlated with variations in surface geology and sources associated with hot spring activity. Exploration techniques for geothermal reservoirs, based upon the spatial distribution of the amplitude and frequency characteristics of short-period seismic noise, are applied and evaluated in a field program at this potential geothermal area.A detailed investigation of the spatial and temporal characteristics of the noise field was made to guide subsequent data acquisition and processing. Contour maps of normalized noise level derived from judiciously sampled data are dominated by the hot spring noise source and the generally high noise levels outlining the regions of thick alluvium. Major faults are evident when they produce a shallow lateral contrast in rock properties. Conventional seismic noise mapping techniques cannot differentiate noise anomalies due to buried seismic sources from those due to shallow geologic effects. The noise radiating from a deep reservoir ought to be evident as body waves of high-phase velocity with time-invariant source azimuth. A small two-dimensional (2-D) array was placed at 16 locations in the region to map propagation parameters. The f-k spectra reveal shallow local sources, but no evidence for a significant body wave component in the noise field was found.With proper data sampling, array processing provides a powerful method for mapping the horizontal component of the vector wavenumber of the noise field. This information, along with the accurate velocity structure, will allow ray tracing to locate a source region of radiating microseisms. In Grass Valley, and probably in most areas of sedimentary cover, the 2-10 Hz microseismic field is predominantly fundamental-mode Rayleigh waves controlled by the very shallow structure.
Effects of 5-HTTLPR genotype and cognitive rumination on long-term cortisol reactivity measured in human hair (2019)

Ample experimental and associative studies have shown that carrying two short (S) alleles of the serotonin transporter gene (5-HTTLPR) contributes to an increased vulnerability for stress and related affective disorders. Recent findings indicate that this relationship might become even more profound when also possessing a negative ruminative (stress-related) thinking style. However, previous studies on the relationship among 5-HTTLPR, stress, and stress-responsiveness almost exclusively measured salivary cortisol concentrations during exposure to a single acute (laboratory) stressor. Measuring cortisol concentrations over longer periods of time might better reflect (chronic) Gene by biological (HPA) stress responsiveness associations. In recent years, the strategy to assess hair cortisol concentration (HCC) has been established as a more reliable marker for chronic HPA activations. The current study explored associations between 3-months accumulated HCC and the tendency to ruminate about negative events in 27 S/S and 27 L/L 5-HTTLPR-carriers (screened from a large n = 827 DNA database). Hierarchical regression (including moderation) analyses revealed clear significant interactions between Genotype and Rumination (p < 0.01, f<sup>2</sup>=0.26); indicating greatest accumulation of HCC in high ruminating S/S-allele carriers. These findings implicate that the combined possession of a genetic (S-allele 5-HTTLPR) and cognitive (Rumination) stress-vulnerability might meaningfully increases long-term stress responsiveness; most likely due to increased daily (chronic) stress experiences. Lay summary The current study investigated whether the combined possession of a biological (genetic) and cognitive (negative thinking pattern) stress vulnerability may lead to a greater vulnerability to experience daily stress. This hypothesis was confirmed as a higher accumulation of the cortisol stress hormone was found over the past 3 months in scalp hair of participants that carried both vulnerability factors in combination.
FOXP3 exon 2 controls T reg stability and autoimmunity (2022)

Differing from the mouse <i>Foxp3</i> gene that encodes only one protein product, human <i>FOXP3</i> encodes two major isoforms through alternative splicing-a longer isoform (FOXP3 FL) containing all the coding exons and a shorter isoform lacking the amino acids encoded by exon 2 (FOXP3 ΔE2). The two isoforms are naturally expressed in humans, yet their differences in controlling regulatory T cell phenotype and functionality remain unclear. In this study, we show that patients expressing only the shorter isoform fail to maintain self-tolerance and develop immunodeficiency, polyendocrinopathy, and enteropathy X-linked (IPEX) syndrome. Mice with <i>Foxp3</i> exon 2 deletion have excessive follicular helper T (T<sub>FH</sub>) and germinal center B (GC B) cell responses, and develop systemic autoimmune disease with anti-dsDNA and antinuclear autoantibody production, as well as immune complex glomerulonephritis. Despite having normal suppressive function in in vitro assays, regulatory T cells expressing FOXP3 ΔE2 are unstable and sufficient to induce autoimmunity when transferred into <i>Tcrb</i>-deficient mice. Mechanistically, the FOXP3 ΔE2 isoform allows increased expression of selected cytokines, but decreased expression of a set of positive regulators of <i>Foxp3</i> without altered binding to these gene loci. These findings uncover indispensable functions of the FOXP3 exon 2 region, highlighting a role in regulating a transcriptional program that maintains T<sub>reg</sub> stability and immune homeostasis.
A Virtual Reality Simulator for Teaching and Evaluating Dental Procedures (2010)

The simulator can simulate realistic tooth surface exploration and cutting. The accuracy of automatic performance assessment system using HMMs is also acceptable on relatively small data sets. The intelligent training allows skill transfer in a proactive manner which is an advantage over the passive method in a traditional training. We will soon conduct experiments with more participants and implement a variety of training strategies.
“Repressed Modernity” and the Turn of Literary History to the “Modernity” Model (2019)

With the introduction of “modernity” in the 1990s, the limitation of the “modernized” model was exposed and finally replaced; thus the new turn of literary history research models from the “modernized” model to the “modernity” one has been started. Li Oufan and David Der-wei Wang’s discussion about the “modernity of the late Qing Dynasty” had a huge influence on academic circles in mainland China, after which, lots of mainland scholars began to study the literature of late Qing Dynasty from the angle of “modernity”, broadening the narrative range of modern literary history and renewing the research perspectives. The writer takes the example of Li Oufan and David Der-wei Wang to study the turn of literary history to the “Modernity” Model.
Airy Beams on Incoherent Background (2022)

We present a class of diffraction-free partially coherent beams, each member of which comprises a finite-power, non-accelerating Airy bump residing on a statistically homogeneous, Gaussian-correlated background. We examine free-space propagation of soft apertured realizations of the proposed beams and show that their evolution is governed by two spatial scales: the coherence width of the background and the aperture size. A relative magnitude of these factors determines the practical range of propagation distances over which the novel beams can withstand diffraction.
Effects of Trust Training on Tee and Pitch Shots in Golf (2007)

This study assessed the effects of a training program designed to enhance trust in the performance of a full swing tee shot and a greenside pitch shot using a repeated measures design with a cohort group. Skilled golfers with an average age of 21.3 years, average golf experience of 11.6 years, and a USGA handicap index of less than 7.0 served as participants. Following baseline performance assessment of six pitch shots, each participant completed a 2-day trust training program. Post-training measurements were taken during blocks of 10 trials for each test shot condition, a 25 m (30-yd) greenside pitch shot and a full swing tee shot with a driver, at 1 and 2 weeks following training Dependent measures included effective distance from a target, self-report measures of tempo, target and trust; process measures of last look at target to backswing start; and body position measures using both digital video and the GolfTEC system Statistical analyses revealed that tempo, target, hip and shoulder tilt were significant predictors of trust, while tempo and trust were significant predictors of effective distance. Results for the pitch shot revealed that when golfers trusted their swing, tempo was rated high and they hit their target, resulting in a 60% improvement in getting closer to the hole. Results for the tee shot suggest that when subjects trusted their swing and tempo was rated one interval higher than when they didn't trust their swing, effective driving distance increased an average of 18.3 m (20 yards). These results suggest that when skilled golfers access trust, their execution of golf shots markedly improves.
Wasserstoffaufnahme beim Einsatzhärten (1999)

Two carburizing techniques were compared in regard to hydrogen intake during carburizing by means of typical carburizing processes. The influence of carburizing process and carbon potential on hydrogen intake was to be investigated. The examined processes were carburizing in endogas-propane-mixtures, with generating the carrier gas outside the furnace in a generator, and carburizing in directly generated methanol-nitrogen-propane-mixtures. The results confirm that differences in the hydrogen intake are to be expected during carburizing in atmospheres generated inside of the furnace or in generator gas atmospheres. After carburizing in endogas-propane-mixtures, the hydrogen content was always less than 5 ppm. Samples carburized in directly generated methanol-nitrogen-propane-mixtures contained not reproducable 4 times more hydrogen. Besides this, there is a hint for a correlation between the hydrogen intake and the carbon potential.
Automated Analysis of Spatially Resolved X-ray Scattering and Micro Computed Tomography of Artificial and Natural Enamel Carious Lesions (2018)

Radiography has long been the standard approach to characterize carious lesions. Spatially resolved X-ray diffraction, specifically small-angle X-ray scattering (SAXS), has recently been applied to caries research. The aims of this combined SAXS and micro computed tomography (µCT) study were to locally characterize and compare the micro- and nanostructures of one natural carious lesion and of one artificially induced enamel lesion; and demonstrate the feasibility of an automated approach to combined SAXS and µCT data in segmenting affected and unaffected enamel. Enamel, demineralized by natural or artificial caries, exhibits a significantly reduced X-ray attenuation compared to sound enamel and gives rise to a drastically increased small-angle scattering signal associated with the presence of nanometer-size pores. In addition, X-ray scattering allows the assessment of the overall orientation and the degree of anisotropy of the nanostructures present. Subsequent to the characterization with µCT, specimens were analyzed using synchrotron radiation-based SAXS in transmission raster mode. The bivariate histogram plot of the projected data combined the local scattering signal intensity with the related X-ray attenuation from µCT measurements. These histograms permitted the segmentation of anatomical features, including the lesions, with micrometer precision. The natural and artificial lesions showed comparable features, but they also exhibited size and shape differences. The clear identification of the affected regions and the characterization of their nanostructure allow the artificially induced lesions to be verified against selected natural carious lesions, offering the potential to optimize artificial demineralization protocols. Analysis of joint SAXS and µCT histograms objectively segmented sound and affected enamel.
Characterization of hepatoprotective metabolites from Artemisia annua and Cleome droserifolia using HPLC/PDA/ESI/MS–MS (2018)

The hepatoprotective activities of two traditionally used plants, Cleome droserifolia (Forssk.) Delile, Cleomaceae, and Artemisia annua L., Asteraceae, were recently reported. However, the biologically active metabolites responsible for this activity were not identified. The aqueous extract of C. droserifolia aerial parts, and the polar fraction of A. annua leaves were screened for their antioxidant activities using the 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) assay. The in vitro viability of HepG-2 cells treated with CCl4 and the extracts were assessed by MTT assay. The effects of the extracts on the liver enzymes and the total soluble protein in CCl4-intoxicated HepG-2 cells were investigated. An HPLC/PDA/ESI/MS–MS based analysis was carried out for extract of C. droserifolia and polar fraction of A. annua. Both exhibited pronounced free radical scavenging activities (86 and 83%, respectively). Both showed a significant increase in cell viability: 86.43% for the extract of C. droserifolia and 79.32% for polar fraction of A. annua. Only the extract of C. droserifolia (39.6 ± 5.41 and 20.4 ± 6.91 IU/dl, respectively) and polar fraction of A. annua (40.8 ± 2.14 and 24.5 ± 3.11 IU/dl, respectively) restored the levels of liver enzymes (aspartate transaminase and alanine transaminase, respectively) compared to the CCl4 intoxicated group (87.5 ± 4.34 and 34.1 ± 8.12 IU/dl, respectively) and other herbal extracts. More than fifty phenolic secondary metabolites were identified in the extracts under investigation. The significant hepatoprotective activities of both extracts seemed to be strongly connected to their content of hydroxycinnamoyl quinic acids and flavonoids.
Supplementary Figures 8-12 from Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244) (2023)

Supplementary Figures 8-12 from Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)
Printed Wide-Slot Antenna for Wideband Applications (2008)

The design and analysis of a novel printed wide-slot antenna, fed by a microstrip line, for wideband communication systems is presented. Detailed simulation and experimental investigations are conducted to understand its behavior and optimize for broadband operation. The designed antenna has a wide operating bandwidth of over 120% (2.8-11.4 GHz) for S11 <-10 dB. In addition to being small in size, the antenna exhibits stable far-field radiation characteristics in the entire operating bandwidth, relatively high gain, and low cross polarization. By properly choosing the suitable slot shape, selecting similar feed shape and tuning their dimensions, the design with very wide operating bandwidth, relatively small size and improved radiation pattern is obtained. A comprehensive parametric study has been carried out to understand the effects of various dimensional parameters and to optimize the performance of the designed antenna. Results show that the impedance matching of this kind of antenna is greatly affected by the feed-slot combination and feed gap width, with the slot shape being a main contributor of the radiation characteristics. The simulated and measured Results for return loss, far-field E and H-plane radiation patterns, and gain of designed antenna are presented and discussed.
ChemInform Abstract: Sulfones of 7‐Silyl‐ and 7‐Germylcephalosporanates. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Model description of photonuclear 13C(γ, p)12B activation detection of carbon (2017)

A model description of the activation detection of carbon with the use of registering 12B-activity produced in a graphite target by a beam of electrons with an energy of 50 MeV due to the photonuclear reaction 13C(γ, p) is presented. This description is carried out with consideration for the influence of the main background process related to the generation of potoneutrons under radiation and secondary background γ′ quanta caused by them. A satisfactory agreement with experimental results is obtained taking into account the incompleteness of data on the conditions of these experiments.
Deep Brain Stimulation in Epilepsy (2001)

Since the pioneering studies of Cooper et al. to influence epilepsy by cerebellar stimulation, numerous attempts have been made to reduce seizure frequency by stimulation of deep brain structures. Evidence from experimental animal studies suggests the existence of a nigral control of the epilepsy system. It is hypothesized that the dorsal midbrain anticonvulsant zone in the superior colliculi is under inhibitory control of efferents from the substantia nigra pars reticulata. Inhibition of the subthalamic nucleus (STN) could release the inhibitory effect of the substantia nigra pars reticulata on the dorsal midbrain anticonvulsant zone and thus activate the latter, raising the seizure threshold. Modulation of the seizure threshold by stimulation of deep brain structures-in particular, of the STN-is a promising future treatment option for patients with pharmacologically intractable epilepsy. Experimental studies supporting the existence of the nigral control of epilepsy system and preliminary results of STN stimulation in animals and humans are reviewed, and alternative mechanisms of seizure suppression by STN stimulation are discussed.
Highly defective graphene： A key prototype of two- dimensional Anderson insulators (2013)

电子结构和运输性质高度有缺点二维(2D ) sp2 graphene 理论上被调查。古典分子的动力学被用来产生包含缺点的可观的数量的大 graphene 飞机。然后， ab initio 计算验证的紧密绑定的 Hamiltonian 被构造以便在一条真实空间的 order-N Kubo 绿林途径以内计算量运输。与太古的 graphene 相对照，高度有缺点的 sp2 碳表在有关联系费用搬运人的电子运输提出挑战性的问题的费用中性点展出状态的高密度。电子 wavepacket 动力学的分析实际上揭示产生象 1 nm 和本地化现象一样低的吝啬的免费路径的极其强壮的多重散布效果。因而，高度有缺点的 graphene 作为 2D 安德森绝缘的一个显著原型被想象材料。
Parallel processing of data from very large-scale wireless sensor networks (2010)

In this paper we explore the problems of storing and reasoning about data collected from very large-scale wireless sensor networks (WSNs). Potential worldwide deployment of WSNs for, e.g., environmental monitoring purposes could yield data in amounts of petabytes each year. Distributed database solutions such as BigTable and Hadoop are capable of dealing with storage of such amounts of data. However, it is far from clear whether the associated MapReduce programming model is suitable for processing of sensor data. This is because typical applications MapReduce is used for, currently are relational in nature, whereas for sensing data one is usually interested in spatial structure of data instead. We show that MapReduce can indeed be used to develop such applications, and also describe in detail a general architecture for service platform for storing and processing of data obtained from massive WSNs.
Reaction of 2-Amino-5-bromo-1,3-thiazoles with Sodium 2-Hydroxyethoxide; Preparation of 2-Amino-3a,5,6,7a-tetrahydro[1,3]thiazolo[1,4]dioxins (1977)

The preparation of 2-amino-3α,5,6,7α-tetrahydro-(1,3)-thiazolo-(1,4)-dioxins from 2-amino-5-bromo-1,3-thiazole is reported
Optimal hysteresis control method for CCM driving of a single-stage PFC flyback converter for LED lightings (2015)

Current control of CCM for various converter applications can be implemented by using hysteresis control method which is simple and easy implementation. Hysteresis control band can be generated using the method for multiplying the current reference. In this case, there might be problems that a high switching frequency is generated in the low current section. In this study, in addition to multiplication method, the sum method and the compound method are proposed. This approach can solve the high switching problem in the low current section. Better power factor, THD and efficiency are also expected. The proposed algorithm was verified through simulation and experiments.