gebhart/patrepeval huggingface dataset:
Abstract 218: Magnesium Deficiency Causes Reversible Diastolic and Systolic Cardiomyopathies by Impairing Mitochondrial Function (2020)

Introduction: Hypomagnesemia is common in patients with diabetes, hypertension, and heart failure. A low circulating Mg level is associated with increased cardiovascular mortality, and conversely, dietary magnesium (Mg) intake is associated with a decreased risk of developing heart failure. In this study, we investigated whether Mg deficiency alone contributed to cardiomyopathy. Methods: C57BL/6J mice were fed with a low-Mg diet (low-Mg, 15-30 mg/kg Mg) or a normal Mg diet (nl-Mg, 600 mg/kg Mg) for 6 weeks. To test reversibility, half of the low-Mg mice were fed then with normal diet for another 6 weeks. Results: Mg deficiency increased mortality. The survival rate after 6-week low-Mg diet was 0 for female and 64.6% for male. Surviving male mice showed significantly decreased serum Mg (0.9±0.1 vs. 2.8±0.1 mg/dL for nl-Mg) and a reciprocal increase in serum Ca, K and Na. Mg deficiency was associated with a decreased ejection fraction (EF%, 39.8±1.9% vs. 52.0±1.7% of nl-Mg), diastolic dysfunction (E/e’: 21.1±1.1 vs. 15.4±0.4 of nl-Mg), and prolonged QTc intervals (55.1±0.8 vs. 46.0±1.2 ms of nl-Mg). At the cellular level, ATP, Ca transient amplitude, resting sarcomere length, and sarcomere shortening were all decreased significantly in low-Mg hearts. These changes were accompanied by significantly increased mitochondrial ROS production. Reintroduction of Mg normalized electrolytes, EF% (52.1±1.4%), E/e’ (15.3±0.7), QTc (49.4±1.7 ms) and cellular changes. SERCA2 was decreased, and oxidation of RyR2 and cardiac myosin binding protein C were increased in low-Mg hearts, all of which were reversed by Mg repletion. In vivo mitoTEMPO treatment on low-Mg mice (1 mg/kg/day IP injection for 2 weeks) improved the diastolic function (E/e’=16.7±2.0) and increased cellular ATP levels. Conclusion: Mg deficiency causes reversible diastolic and systolic cardiomyopathy associated with mitochondrial dysfunction. This cardiomyopathy may explain the relationship of hypomagnesemia and worsening heart failure. Mg intake reverses these changes, reinforcing the known correlation of increased Mg intake and reduced heart failure symptoms. In deficiency states, Mg supplementation may represent a novel treatment for both diastolic and systolic heart failure.
Gomoku: analysis of the game and of the player Wine (2021)

Gomoku, also known as five in a row, is a classical board game, ideally suited for quickly testing novel Artificial Intelligence (AI) techniques. With the aim of facilitating a developer willing to write a new Gomoku player, in this report we present an analysis of the main game concepts and strategies, which is wider and deeper than existing ones. Moreover, after discussing the general structure of an artificial player, we present and analyse a strong Gomoku player, named Wine, the code of which is freely available on the Internet and which is an excelent example of how a modern player is organised.
Septins disruption controls tumor growth and enhances efficacy of Herceptin (2020)

Abstract Septin expressions are altered in cancer cells and exhibit poor prognoses in malignancies. As the first approach to develop a septin filament targeting agent, we optimized the structure of Forchlorfenuron (FCF), a known plant cytokinin to generate UR214-9, which contrary to FCF, causes septin-2/9 filamental structural catastrophe in cancer cells without altering cellular septin protein levels. In-silico docking using septin-2/septin-2 dimer complex showed that UR214-9 displaced the guanine carbonyl oxygen from the GDP binding domain and showed increased binding energy than FCF(−8.59vs-7.21). UR214-9 reduced cancer cell growth, downregulated HER2/STAT-3 axis and controlled growth of HER2+ pancreatic, breast and ovarian cancer xenografts in NSG mice and enhanced response of Herceptin against HER2+breast cancer xenograft. Transcriptome analysis of UR214-9 exposed cells demonstrated significant perturbation of &lt;20 genes compared to afatinib which impacted &gt;1200 genes in JIMT-1 breast cancer cells indicating target specificity and non-transcriptional functions of UR214-9. In summary, disrupting septins via UR214-9 is a new approach to control the growth of HER2+ malignancies.
Ceramic Series. Alan Heaps (1988)

The catalogue contains six b&amp;w images of ceramic pieces by Heaps, a portrait of Heaps at work and an article by Jenny Heaps. Please note the catalogue is undated, therefore the date given is approximate.
Asymptotic capacity analysis of transmit antenna selection (2004)

In this work we investigate the asymptotic behavior of the capacity of transmit antenna selection, in the limit of large number of transmit antennas, under both low and high SNR regimes. Antenna selection provides a low-cost low complexity solution for MIMO systems.
Reduction of Power Transformer Core Noise Generation Due to Magnetostriction-Induced Deformations Using Fully Coupled Finite-Element Modeling Optimization Procedures (2017)

This paper focuses on the development of an algorithm for the prediction of transformer core deformation, using a fully coupled magneto-mechanical approach. An imposed magnetic flux method coupled with finite-element modeling is employed for the magnetic resolution. The constitutive law of the material is considered with a simplified multi-scale model describing both magnetic and magnetostrictive anisotropies. Magnetostriction is introduced as an input free strain of a mechanical problem to get the deformation and displacement fields. A 3-D estimation of acoustic power is carried out to evaluate the global core deformation and acoustic noise level. The numerical process is applied to a three-phase transformer made of grain-oriented FeSi core, leading to a set of noise estimation for different flux excitations and core geometries.
A new spirit for fostering organizational success (2012)

Purpose Outlines and reports on a radical new approach to developing both an organization and its people to enable those people to be themselves in body, mind and spirit while at work and so feel fulfilled – and, in the process, enable the organization to be more successful. Design/methodology/approach Outlines the philosophy of Ecumenical Partnership Initiatives Compassion in Change (EPICC), a part of Workplace Matters; summarizes key industry trends identified in relevant research, and sets out EPICC's question‐based approach to achieving its clients' goals. Findings Reports research findings that only 20 percent of employees in large organizations feel their strengths are used every day and eight out of ten employees feel miscast in their job. Outlines a new way of business thinking with regard to human resources and development. Reports that, when dealing with business issues within the social paradigm, it is important to be open to things of the spirit. Practical implications Describes how people can “take their whole selves to work” and how organizations can reap the full benefits of encouraging this policy. Social implications Contends that financial results will be better, customers will be delighted and staff will thrive where the business can find the right balance between two management paradigms: the dominant economic – finance based, short term, zero‐sum, process, rational, controlling – and the emerging social paradigm based around relationships, ethics and inspiration. Originality/value Contains important insights into how this balance can be achieved.
Enhanced Liquid Crystal Alignment Using Photo-Irradiation of Photo-Dissociative Polyimide (2011)

Exposure of photo-labile polyimide film to linearly polarized 254 nm UV incurred anisotropic dielectric orientation of film surface. The anisotropic surface resulted from the liquid crystal (LC) alignment is perpendicular to polarization direction of the UV irradiation. The polyimide (1,2,3,4-cycolbutanetetrcatboxylic dianhydride di(4 aminophenyl)methane-dianhydride)(CBDA-DAPM-DA) contains cyclobutane rings for photoinduced ring opening reaction. The LC alignments were obtained through polarized and unpolarized UV by exposing them to rubbed polyimide film. Dichroic ratio of LC cells increased with irradiation time until 20 min and was followed by disordering of further UV irradiation. Unpolarized UV irradiation on the rubbed polyimide film showed increased dichroic ratio compared to the films irradiated with a polarized UV light.
Mobility management solutions for current IP and future networks (2015)

Enormous progress in the design of portable electronic devices allowed them to reach a utility level comparable to desktop computers, while still retaining their mobility advantage. At the same time new multimedia services and applications are available for IP users. Unfortunately, the performance of base IP protocol is not satisfactory in mobile environments, due to lack of handover support and higher layer mobility management mechanisms. In this paper, we outline the most important current methods of handling mobility in IP networks that are expected to play an important role in the future (covering the following ISO–OSI layers: 2+, 3, 3+, 4 and 7 of mobility solutions), as well as describe the newly proposed methods.
Synchronous Breast Cancer: Phenotypic Similarities on MRI (2019)

3 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2020;51:1858-1867.
PO-238 Dichloroacetate (DCA) treatment affects mitochondrial activity and stemness in pancreatic cancer (PC) cell lines (2018)

Introduction Targeting metabolism represents a new approach to treat cancer, expecially when conventional chemoterapy fails. In this study, we tested a metabolic approach to treat PC, investigating, in vitro and in vivo, its response to DCA treatment. Material and methods Two PC cell lines, BXPC3 and PANC1, were treated with DCA 4 and 10 mM for 24 hour. Cell viability and proliferation were assessed by MTS assay and xCELLigence, apoptosis and ROS by flow-cytometry; pPDH Ser293 /tot PDH, LC3B, DRP1, MFN1, MNF2, OPA1 and TOMM20 protein expression was evaluated by western blotting, lin28 gene expression by qPCR. The oxygen consumption rate (OCR) and extra-cellular acidification rate (ECAR) were measured by Seahorse Technology. Ultra-low attachment plates were used to form spheroids. In vivo, DCA was administered to BXPC3-luc tumor-bearing nude mice. After measuring bioluminescence signalling, the tumour masses were harvested, photographed and weighed. Results and discussions DCA treatment reduced cell proliferation, decreasing cell survival with an increase in ROS production and apoptosis in both cell lines. Despite PDH activation by dephosphorylation, DCA did not restore bioenergetic profile but decreased OCR, a measure of oxidative phosphorylation efficiency. ECAR was not affected, suggesting that the glicolytic capacity was not modified by DCA treatment. These observations led us to explore mitophagy, whose activation was confirmed by LC3B protein overexpression and TOMM20 downregulation, and mitochondrial dynamics also altered following DCA treatment as shown by the downregulation of MFN1, MFN2, OPA1, key proteins of mitochondrial fusion. Interestingly, DCA was able to negatively affect the cancer stem cell (CSCs) fraction in both cell lines, reducing the expression of stemness genes such as Lin28 and inhibiting spheroid formation. When added to 3D cultures already formed, it was able to downregulate stemness genes expression, leading to a significant size reduction and affecting spheroid viability. Finally, DCA efficacy was confirmed in a xenograft pancreatic cancer mouse model in which DCA treatment displayed a significant retarded progression of PC, reducing diameter of the tumour mass. Conclusion Our data suggest that DCA is able to strongly affect PC cells metabolism counteracting mitochondrial activity. This effect is not related to PDH activity stimulation. In addition, the ability of DCA to hit CSCs offers a further rationale to candidate this drug for PC treatment, trying to reach a complete tumour eradication.
Facile O-Arylation of Phenols and Carboxylic Acids (2003)

[reaction: see text] A facile, transition-metal-free O-arylation procedure for phenols and aromatic carboxylic acids has been developed that affords good to excellent yields of arylated products under very mild reaction conditions. A methoxy-substituted aryl triflate affords O-arylated products in high yields with excellent regioselectivity. This chemistry tolerates a variety of functional groups.
A decision theoretic approach to combining information filtering (2009)

Purpose The purpose of this paper is to present an extension to a framework based on the information structure (IS) model for combining information filtering (IF) results. The main goal of the framework is to combine the results of the different IF systems so as to maximise the expected payoff (EP) to the user. In this paper we compare three different approaches to tuning the relevance thresholds of individual IF systems that are being combined in order to maximise the EP to the user. In the first approach we set the same threshold for each of the IF systems. In the second approach the threshold of each IF system is tuned independently to maximise its own EP (“local optimisation”). In the third approach the thresholds of the IF systems are jointly tuned to maximise the EP of the combined system (“global optimisation”). Design/methodology/approach An empirical evaluation is conducted to examine the performance of each approach using two IF systems based on somewhat different filtering algorithms (TFIDF, OKAPI). Experiments are run using the TREC3, TREC6, and TREC7 test collections. Findings The experiments reveal that, as expected, the third approach always outperforms the first and the second, and that for some user profiles, the difference is significant. However, operational goals argue against global optimisation, and the costs of meeting these operational goals are discussed. Research limitations/implications One limitation is the assumption of independence of the IF systems: in real life systems usually use similar algorithms, so dependency might occur. The approach also tends to be examined with the assumption of dependency between systems. Practical implications The main practical implications of this study lie in the empirical proof that combination of filtering systems improves filtering results and the finding about the optimal combination methods for the different user profiles. Many filtering applications exist (e.g. spam filters, news personalisation systems, etc.) that can benefit from these findings. Originality/value The study presents and compares the contribution of three different combination methods of filtering systems to the improvement of filtering results It empirically shows the benefits of each method and draws important conclusions about the combination of filtering systems.
The Structural Requirements for an Inverse Substrate for Enzymatic Peptide Synthesis: Position Isomers of Guanidinonaphthyl Esters as the Acyl Donor Component. (1999)

Four series of inverse substrates, position isomers of guanidinonaphthyl esters derived from N-(tert-butyloxycarbonyl)amino acid, were prepared as acyl donor components for trypsin-catalyzed peptide synthesis. The kinetic behavior of these synthetic inverse substrates toward spontaneous and tryptic hydrolysis was analyzed. These substrates were found to readily couple with α-amino acid p-nitroanilide to produce peptide. 4-Guanidino-1-naphthyl esters, in which the guanidino group and the carbonyl group are aligned linearly on the shorter axis of the naphthalene ring, were the most efficient substrates for enzymatic peptide synthesis. The method was especially useful for the preparation of peptides containing α, α-dialkyl amino acids. The enzymatic hydrolysis of the resulting products was negligible.
Dynamic effects in visual closed-loop systems (1996)

In this paper we argue that the focus of much of the visual servoing literature has been on the kinematics of visual control and has ignored a number of fundamental and significant dynamic control issues. To this end the concept of visual dynamic control is introduced, which is concerned with dynamic effects due to the manipulator and machine vision sensor which limit the performance. These must be explicitly addressed in order to achieve high-performance control. The paper uses simulation and experiment to investigate the feedback control issues such as the choice of compensator, and the use of axis position, velocity or torque controlled inner-loops within the visual servo system. The limitations of visual feedback control lead to the investigation of target velocity feedforward control, which combined with axis velocity control, is shown to result in robust and high performance tracking.
EP25.02: Does pregnancy outcome in the first trimester correlate with the amount of vaginal bleeding and pain? A preliminary study (2016)

Early pregnancy events, such as pain and bleeding, are associated with increased risk of miscarriage. We aimed to study whether the presence and amount of pain and/or bleeding in the first trimester correlated with the risk of miscarriage. Prospective study of women recruited through the early pregnancy unit intrauterine pregnancies diagnosed using transvaginal ultrasonography. All women completed a questionnaire with symptom details. Bleeding was assessed using a modified pictorial blood assessment chart (PBAC) bleeding score. The amount of bleeding on the day, and the worst bleeding experienced, and duration was recorded. Pain was assessed using a visual pain score; score and duration was collected. Vomiting was evaluated using the pregnancy-unique quantification of emesis and nausea (PUQE) scoring system. Participants underwent a transvaginal ultrasound scan every two weeks until 12 weeks gestation. At each visit the symptom questionnaire was completed. 201 women were recruited. When comparing all women with bleeding versus those without bleeding, there was no difference in pregnancy outcome (p = 0.0847). Women who reported higher bleeding scores had a greater risk of miscarriage (p = 1.124e-06). Higher pain scores were also associated with significantly higher risk of miscarriage (p = 0.00242). Women with higher PUQE scores were more likely to have viable pregnancy at 12 weeks (p = 2.879e-06). The greater the difference between the expected embryo size compared with the observed embryo size using ultrasonography, the greater the risk of miscarriage (p-value = 6.787e-07). We have shown that women with higher pain and bleeding scores, and with greatest discrepancy of observed versus expected embryo size, are more likely to suffer a first trimester miscarriage. Nausea and vomiting seems to be protective and associated with pregnancy viability. This information can be used to better counsel women about their risk of miscarriage.
Effect of repetition rate on the formation of microtears in tendon in an in vivo cyclical loading model (2007)

We reported previously the formation of microtears in an in vivo loaded Flexor Digitorum Profundus (FDP) rabbit tendon with a repetition rate of 60 repetitions per minute and a peak force of 15% of maximum peak tetanic force for 80 cumulative hours. Tear area as a percent of tendon area, tear density (tears/mm(2)), and mean tear size (microm(2)) were higher in tendons from the loaded limb compared to the unloaded control limb. The purpose of the present study was to compare those results to results obtained with a repetition rate of 10 while maintaining the same peak force and force-time integral (n = 8). Due to a strain gradient between the inner and outer sides of the FDP tendon, microtears were quantified in four regions, two regions each along the inner and outer sides of the tendon. The tear area as a percent of total tendon area and the mean tear size were significantly greater in the loaded limb compared to the unloaded limb (p < 0.03). However, the effects were less than those observed at 60 repetitions/min. The higher repetition loading pattern resulted in an increase in tear measures in all four regions, while the lower rate produced changes only in the outer regions of the tendon. This finding may establish where the initial sites of damage occur in tendons that insert into bone in a similar arrangement as the FDP. The results suggest that repetition rate or number of loading cycles is associated with increased tendon microtears or fragility in a dose-response pattern.
Automated calculation of point A coordinates for CT-based high-dose-rate brachytherapy of cervical cancer (2017)

The study demonstrates that the automated algorithm calculates point A coordinates consistently, while reducing inter-user variability. Point placement using the algorithm expedites the planning process and minimizes associated potential human errors.
Impact of PTEN/AKT/PI3K signal pathway on the chemotherapy for gastric cancer (2006)

4034 Background: Growth factor receptor-mediated signal transduction has been recently implicated in conferring resistance to conventional chemotherapy on cancer cells. We have described a pathway that involves AKT/PI3K to mediate chemoresistance in gastric cancer patients. The phosphatase activity of PTEN is crucial in controlling the phosphatidylinositol-3 (PI-3) kinase signal transduction pathway and in the activation of the protein kinase B(PKB/Akt) proto-oncogene. This indicates that PTEN exerts its tumor-suppressor function by negatively regulating the anitapoptotic PI3-kinase/AKT signaling pathway. Methods: Primary gastric carcinoma tissues and corresponding normal mucosa were obtained from 119 gastric cancer patients who underwent surgery in the Department of Surgery II in Kyushu University Hospital from the years 1996 to 2000. Methylation of PTEN was studied with methylation-specific PCR and LOH (loss of heterozygosity) of PTEN was studied using a DNA sequencer with D10S796 and D10S1173 microsatellite marker in the same samples. AKT activation was investigated by immunostaining with a phosphorylation-specific antibody. The chemotherapeutic sensibilities of these patients were investigated using an MTT assay. Results: We found that methylation of PTEN was rarely recognized, However, the gastric cancer patients who had a higher AKT phosphorylation (activated AKT) appeared to have LOH of PTEN (p &lt; 0.0008), and the prognosis of the patient who has LOH of PTEN was significantly poor. When the chemotherapeutic sensibilities of these patients were studied in an MTT assay, it was found that the activated AKT was associated with increased resistance to multiple chemotherapeutic agents, which included those currently used on gastric cancer patients (5-fluorouracil, adriamycin, mitomycin C, and cis-platinum). Conclusions: The results of this study indicate that AKT activation and LOH of PTEN plays an important role in conferring a broad-spectrum chemoresistance in gastric cancer patients. It also indicates that clinical trials for an appropriate chemotherapy combination with conventional drugs and a new generation of signal transduction inhibitors that inhibit the PTEN/AKT pathway should be considered in treating gastric cancer in the near future. No significant financial relationships to disclose.