gebhart/patrepeval huggingface dataset:
Genenames.org: the HGNC and VGNC resources in 2017 (2016)

The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. Currently the HGNC database contains almost 40 000 approved gene symbols, over 19 000 of which represent protein-coding genes. In addition to naming genomic loci we manually curate genes into family sets based on shared characteristics such as homology, function or phenotype. We have recently updated our gene family resources and introduced new improved visualizations which can be seen alongside our gene symbol reports on our primary website http://www.genenames.org In 2016 we expanded our remit and formed the Vertebrate Gene Nomenclature Committee (VGNC) which is responsible for assigning names to vertebrate species lacking a dedicated nomenclature group. Using the chimpanzee genome as a pilot project we have approved symbols and names for over 14 500 protein-coding genes in chimpanzee, and have developed a new website http://vertebrate.genenames.org to distribute these data. Here, we review our online data and resources, focusing particularly on the improvements and new developments made during the last two years.
Self-diffusion in molten alkali halides (1961)

J. O'M. Bockris and G. W. Hooper, Discuss. Faraday Soc., 1961, 32, 218 DOI: 10.1039/DF9613200218
Time-resolved surface-enhanced resonance Raman spectro-electrochemistry of heme proteins (2010)

Heme proteins such as cytochrome c (cc) play a fundamental role in many biological processes. Surface-enhanced resonance Raman spectroscopy (SERRS) combined with electrochemical methods is an ideal tool to study the redox processes of heme proteins. In this context we designed a new measuring cell allowing for simultaneous electrochemical manipulation and high sensitive SERRS measurements of heme proteins. The measuring cell is based on an inverted rotating disc electrode for excitation by using a confocal Raman microscope. Furthermore, we developed a SER(R)S-active silver modified silver substrate for spectro-electrochemical applications. For this purpose silver nanoparticles (AgNPs) were adsorbed on top of a planar silver surface. The substrate was optimized for an excitation wavelength of 413 nm corresponding to the resonance frequency of heme structures. An enhancement factor of 10 5 was achieved. The high performance of the new measuring cell in combination with the new silver substrate was demonstrated using cc as a reference system.
Minimization of cogging force in a linear permanent magnet motor (1998)

A finite element/analytically based method is used to aid the minimization of cogging force, due to slotting and the finite length of the ferromagnetic core, in a tubular brushless permanent magnet motor. The method is validated against both finite element calculations and measurements on a prototype motor.
Reliable assumptions for structural fire design of steel car parks (2021)

Purpose This study aims to analyze and discuss the key design assumptions needed for design of car parks in steel, to highlight the impact that the increased fire loads introduced by modern cars and changes in the fire dynamics have on the design, such as fire spread leading to non-localized fires. Design/methodology/approach In particular, a reliable fire load density to be used for structural design of car park structures is assessed, based on investigations of the fire loads of modern cars. Based on knowledge of fire load and fire performance of cars, the consequences on the fire safety design of steel structures are presented. Findings Design recommendation about fire load density and fire protection of common steel profiles are given. Finally, the proposed design is compared with a design practice that has been applied in many instances for car parks constructed with unprotected steel, and recommendations for a reliable design process are provided. Originality/value Numerous car park buildings have recently been designed of steel structures without passive or active fire protection. The key assumptions that makes possible such design are local fire scenarios, outdated values of the car fire load and utilization of the ultimate steel strength. This paper identifies the shortcomings of such key assumptions, indicating the need for revisiting the methods and possibly even checking the analyses carried out for some already-built car parks.
Continuous Flow Microfluidic Bioparticle Concentrator (2015)

Innovative microfluidic technology has enabled massively parallelized and extremely efficient biological and clinical assays. Many biological applications developed and executed with traditional bulk processing techniques have been translated and streamlined through microfluidic processing with the notable exception of sample volume reduction or centrifugation, one of the most widely utilized processes in the biological sciences. We utilize the high-speed phenomenon known as inertial focusing combined with hydraulic resistance controlled multiplexed micro-siphoning allowing for the continuous concentration of suspended cells into pre-determined volumes up to more than 400 times smaller than the input with a yield routinely above 95% at a throughput of 240 ml/hour. Highlighted applications are presented for how the technology can be successfully used for live animal imaging studies, in a system to increase the efficient use of small clinical samples, and finally, as a means of macro-to-micro interfacing allowing large samples to be directly coupled to a variety of powerful microfluidic technologies.
Evidence of associations between brain-derived neurotrophic factor (BDNF) serum levels and gene polymorphisms with tinnitus (2017)

This study suggests neurotrophic factors such as BDNF may have a role in tinnitus etiology. Future studies with larger sample size may be required to further confirm our results.
Using the virus challenge dose in the analysis of virus neutralization assays (1992)

We propose a new basis for adjusting the results of virus neutralization assays. These assays consist of two separate experiments performed in parallel: a virus titration experiment and a serum dilution assay. In the virus titration experiment, one estimates the amount of virus used in the assay (the virus challenge dose). In a typical virus neutralization assay, the virus challenge dose may range over an order of magnitude. In the serial dilution assay, one measures the serum neutralizing activity against a particular virus. Most standard methods use the virus titration results only to ensure that the overall experiment is acceptable; the specific results of the virus titration experiment are not used to adjust the estimate of serum neutralizing activity. Although adjustment based on calibration with reference sera could be done, this seldom occurs in practice. We use results from recent studies of the kinetics and stoichiometry of polio virus neutralization with monoclonal antibodies to develop a method to use results from the virus titration experiment to adjust the serum neutralizing activity directly. Our results also indicate that a simple ad hoc procedure can improve the accuracy of the estimated serum neutralizing activity.
Data from Pharmacokinetic Dose-Scheduling Study of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; This study was designed to evaluate whether less frequent dosing [three times per week (TIW) or once weekly (QW)] of 150 mg vismodegib following a loading dose [150 mg once daily (QD) for 11 days] would result in similar safety, tolerability, and steady-state levels of total and unbound vismodegib as continuous QD dosing.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Sixty-seven patients with advanced solid tumors were stratified by baseline plasma alpha 1-acid glycoprotein (AAG) levels and randomized to one of three vismodegib 150 mg regimens: QD (&lt;i&gt;n&lt;/i&gt; = 23), TIW (&lt;i&gt;n&lt;/i&gt; = 22), or QW (&lt;i&gt;n&lt;/i&gt; = 22) for up to 42 days after an 11-day loading phase (150 mg QD). Total and unbound (dialyzed) plasma vismodegib concentrations were determined by LC-MS/MS.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; The most frequently reported adverse events were consistent with those in prior monotherapy trials, with similar incidence and severity regardless of dosing schedule. After the 150 mg QD loading phase, a concentration-dependent change in protein binding (3-fold increase in vismodegib fraction unbound) was observed at steady state compared with single dose. Mean total and unbound vismodegib steady-state concentrations were lower after TIW and QW than QD dosing, with an average intrasubject decrease of 50% and 80%, respectively, for unbound drug. Mechanism-based PK model simulations accurately and prospectively predicted the PK results.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Vismodegib 150 mg TIW or QW failed to achieve unbound plasma concentrations previously associated with efficacy in patients with advanced basal cell carcinoma and medulloblastoma, even after a QD loading dose period. The 150 mg QD regimen is appropriate for vismodegib based on its clinical activity, tolerability, and favorable unbound concentrations. &lt;i&gt;Clin Cancer Res; 17(17); 5774–82. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Victorian Student Representative Council (VicSRC) (2010)

Victorian Student Representative Council (VicSRC) is an international and humanitarian aid advocating for student and teacher consumption of Fair Trade products. The Conference aims to develop leadership skills, present students with opportunities to exchange ideas and share information, engage in thought provoking discussions that examine issues of concern within their schools and SRCs.
Chemical sensors (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical sensorsJiri. JanataJiri. JanataMore by Jiri. JanataCite this: Anal. Chem. 1990, 62, 12, 33–44Publication Date (Print):June 15, 1990Publication History Published online1 May 2002Published inissue 15 June 1990https://doi.org/10.1021/ac00211a003Request reuse permissionsArticle Views376Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alertsclose Get e-Alerts
Experimental results of floating platform vibration control with mode change function using full-scale spar-type floating offshore wind turbine (2017)

Floating offshore wind turbines have great potential for harvesting renewable energy sources since offshore wind is stronger and more stable than onshore wind. The foundations of floating offshore wind turbines are not rigidly fixed and it leads to vibration of the floating platform pitch angle. This vibration is caused by fast blade pitch angle motions of variable speed control for controlling rotor speed at rated values. This study proposes a control method to address this vibration, floating platform vibration control. This method extracts a natural frequency component of the vibration from the floating platform pitch angle signal by a band pass filter and controls the blade pitch angle on the basis of proportional–derivative control. Its key characteristic is changing control modes in accordance with electrical power. Experiments using a full-scale spar-type floating offshore wind turbine were performed, and results show that the proposed floating platform vibration control can suppress the vibration of floating platform pitch angle.
Characterization of Ixophilin, A Thrombin Inhibitor from the Gut of Ixodes scapularis (2013)

Ixodes scapularis, the black-legged tick, vectors several human pathogens including Borrelia burgdorferi, the agent of Lyme disease in North America. Pathogen transmission to the vertebrate host occurs when infected ticks feed on the mammalian host to obtain a blood meal. Efforts to understand how the tick confronts host hemostatic mechanisms and imbibes a fluid blood meal have largely focused on the anticoagulation strategies of tick saliva. The blood meal that enters the tick gut remains in a fluid state for several days during the process of feeding, and the role of the tick gut in maintaining the blood-meal fluid is not understood. We now demonstrate that the tick gut produces a potent inhibitor of thrombin, a key enzyme in the mammalian coagulation cascade. Chromatographic fractionation of engorged tick gut proteins identified one predominant thrombin inhibitory activity associated with an approximately 18 kDa protein, henceforth referred to as Ixophilin. The ixophilin gene was preferentially transcribed in the guts of feeding nymphs. Expression began after 24 hours of feeding, coincident with the flow of host blood into the tick gut. Immunity against Ixophilin delayed tick feeding, and decreased feeding efficiency significantly. Surprisingly, immunity against Ixophilin resulted in increased Borrelia burgdorferi transmission to the host, possibly due to delayed feeding and increased transmission opportunity. These observations illuminate the potential drawbacks of targeting individual tick proteins in a functional suite. They also underscore the need to identify the "anticoagulome" of the tick gut, and to prioritize a critical subset of anticoagulants that could be targeted to efficiently thwart tick feeding, and block pathogen transmission to the vertebrate host.
Subthalamic nucleus stimulation modulates afferent inhibition in Parkinson disease (2007)

Subthalamic nucleus (STN) stimulation improves short latency afferent inhibition, suggesting that it could normalize pathways that are adversely affected by dopaminergic medications. The effect of STN stimulation on long latency afferent inhibition suggests that it may influence nondopaminergic pathways involved in sensorimotor integration.
Non-intrusive electrical load monitoring and profiling methods for applications in energy management systems (2011)

"Phantom Loads" cause energy waste in homes and the built environment as a whole. Consumers spend more than $3 billion a year on "Phantom Load" in the United States alone. The goal of this paper is to conserve energy by increasing consumer awareness on their energy usage and reducing and /or eliminating phantom loads in the built environment. A further goal is to improve upon existing power distribution systems in the built environment with limited hardware additions to increase energy conservation. This paper investigates remote identification of load types and the locations along the electrical circuitry where they (load) are being consumed. The load type and status (on, off, standby) are determined both remotely and in a non-intrusive manner using Non-Intrusive Load Monitoring Methods. Time/Frequency Domain Reflectometry (TDR) is also being investigated to remotely locate energy consumption nodes along the electrical circuitry.
A 29.5 dBm class-E outphasing RF power amplifier with performance enhancement circuits in 45nm CMOS (2014)

A high efficiency class-E outphasing RF power amplifier is presented using a new passive combining circuit. A Power Enhancement Circuit (PEC) and an Efficiency Enhancement Circuit (EEC) are also proposed as part of the combiner that increase output power without violating reliability limits and improve efficiency at power back-off, respectively. The proposed power amplifier is designed in 45nm CMOS technology. Simulation results and measurement data are presented to demonstrate the performance of the proposed PA. The PA delivers 29.5 dBm peak output power at 2.4GHz with 46.76% drain efficiency at peak output power, 32.96% drain efficiency at 3 dB power back-off and 21.16% drain efficiency at 6 dB power back-off. Better than -50 dBc ACPR is obtained with 64-QAM LTE signal with 10MHz and 20MHz bandwidth. 21% average efficiency is obtained with LTE signal with 6 dB peak-to-average power ratio (PAPR).
Gas Mixtures: Preparation and Control (1992)

The H5N1 NS genomic segment distinctly up-regulated the viral infectivity and induction of IFN-α compared to the rgPR8, rgH1N1sea-NS and rgH3N2-NS viruses.
Granule‐Bound Starch Synthase I (GBSSI) in Quinoa (Chenopodium quinoa Willd.) and Its Relationship to Amylose Content (2005)

ABSTRACT The amylose concentration in starch from 16 quinoa ( Chenopodium quinoa Willd.) genotypes grown under identical conditions was 4–20%. Based on the amylose content, a selection of six genotypes was made. Starch granule‐bound proteins were extracted from six genotypes and analyzed using denaturing gel electrophoresis. Two major polypeptides with apparent molecular masses of 56 and 62 kDa were present in all genotypes. Both were identified as granule‐bound starch synthase I (GBSSI) using immunoblot analysis and internal peptide sequencing. The content of the two GBSSI isoforms in starch granules from the six genotypes, as determined by densiometry of the peptide bands, was positively correlated with the concentration of amylose in starch from mature seed. Starch synthase activity in developing seed was positively correlated to starch concentration in seed and amylose concentration in starch during seed development.
Repurposing Non-Antimicrobial Drugs and Clinical Molecules to Treat Bacterial Infections (2015)

There is a pressing need to develop novel antimicrobials to circumvent the scourge of antimicrobial resistance. The objective of this study is to identify non-antibiotic drugs with potent antimicrobial activity, within an applicable clinical range. A library, containing 727 FDA approved drugs and small molecules, was screened against ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae). Drugs that showed antimicrobial activity in an applicable clinical range were further tested in vitro and in vivo in an infected mouse model. The initial screening identified 24 non-antibiotic drugs and clinical molecules active against Gram-positive pathogens including methicillin- resistant S. aureus (MRSA) and vancomycin-resistant enterococcus (VRE) isolates. Two non-antibiotic drugs showed activity against Gram-negative pathogens. Among the active non-antibiotic drugs, only ebselen (EB) and 5-fluoro-2'-deoxyuridine (FdUrd), showed bactericidal activity, in an applicable clinical range, against multi-drug-resistant Staphylococcus isolates including MRSA, vancomycin-resistant S. aureus (VRSA), and vancomycin-intermediate S. aureus (VISA). The minimum inhibitory concentration at which 90% of clinical isolates of S. aureus were inhibited (MIC90) was found to be 0.25 and 0.0039mg/L for EB and FdUrd, respectively. Treatment with EB orally significantly increased mice survival in a lethal model of septicemic MRSA infection by (60%) compared to that of control. FdUrd oral and intraperitoneal treatment significantly enhanced mouse survival by 60% and 100%, respectively. These data encourage screening and repurposing of non-antibiotic drugs and clinical molecules to treat multidrug-resistant bacterial infections.
Retinal hemorrhage and vacuum extraction delivery. (1986)

The purpose of this prospective study was to investigate whether there is an increased risk of retinal hemorrhage in those infants delivered with the assistance of the silastic vacuum extractor from mothers who were low-risk and who had normal labors. Ocular fundi of 38 term newborns (19 vacuum assisted deliveries, 19 spontaneous deliveries) were examined for retinal hemorrhage within 72 hours after delivery. The overall frequency of retinal hemorrhage was 21.1%, 31.6% with the vacuum extractor and 10.5% with a spontaneous delivery. The mode of delivery did influence the number of infants with hemorrhages in each category, however this was only statistically significant in primiparous patients. The prognostic significance of the degree of retinal hemorrhage was not assessed.
Time Constrained Continuous Subgraph Search over Streaming Graphs (2018)

The growing popularity of dynamic applications such as social networks provides a promising way to detect valuable information in real time. Efficient analysis over high-speed data from dynamic applications is of great significance. Data from these dynamic applications can be easily modeled as streaming graph. In this paper, we study the subgraph (isomorphism) search over streaming graph data that obeys timing order constraints over the occurrence of edges in the stream. We propose a data structure and algorithm to efficiently answer subgraph search and introduce optimizations to greatly reduce the space cost, and propose concurrency management to improve system throughput. Extensive experiments on real network traffic data and synthetic social streaming data confirms the efficiency and effectiveness of our solution.
To the Flag: The Unlikely History of the Pledge of Allegiance by Richard J. Ellis (2006)

Journal Article To the Flag: The Unlikely History of the Pledge of Allegiance by Richard J. Ellis Get access To the Flag: The Unlikely History of the Pledge of Allegiance by Richard J. Ellis. Lawrence, University Press of Kansas, 2005. 297 pp. $29.95. David Greenberg David Greenberg Rutgers University Search for other works by this author on: Oxford Academic Google Scholar Political Science Quarterly, Volume 121, Issue 1, Spring 2006, Pages 172–174, https://doi.org/10.1002/j.1538-165X.2006.tb01478.x Published: 25 March 2013
Structural insights into anaphase-promoting complex function and mechanism (2011)

The anaphase-promoting complex or cyclosome (APC/C) controls sister chromatid segregation and the exit from mitosis by catalysing the ubiquitylation of cyclins and other cell cycle regulatory proteins. This unusually large E3 RING-cullin ubiquitin ligase is assembled from 13 different proteins. Selection of APC/C targets is controlled through recognition of short destruction motifs, predominantly the D box and KEN box. APC/C-mediated coordination of cell cycle progression is achieved through the temporal regulation of APC/C activity and substrate specificity, exerted through a combination of co-activator subunits, reversible phosphorylation and inhibitory proteins and complexes. Recent structural and biochemical studies of the APC/C are beginning to reveal an understanding of the roles of individual APC/C subunits and co-activators and how they mutually interact to mediate APC/C functions. This review focuses on the findings showing how information on the structural organization of the APC/C provides insights into the role of co-activators and core APC/C subunits in mediating substrate recognition. Mechanisms of regulating and modulating substrate recognition are discussed in the context of controlling the binding of the co-activator to the APC/C, and the accessibility and conformation of the co-activator when bound to the APC/C.