gebhart/patrepeval huggingface dataset:
RELATIONS ENTRE LES PROPRIETES DES BITUMES MODIFIES AUX POLYMERES ET LES PRODUITS D'ETANCHEITE OU LE MATERIAUX POUR LA CONSTRUCTION ROUTIERE - THEME 2 (1989)

CE THEME COMPREND 2 PARTIES : A - METHODES SIGNIFICATIVES POUR LES PRODUITS D'ETANCHEITE QUI CONTIENT LES COMMUNICATIONS SUIVANTES : LABORATORY TESTS OF POLYMER-MODIFIED BITUMEN SHEETS FOR WATERPROOFING OF CONCRETE BRIDGE DECKS. EXPERIENCE IN SWEDEN (COLLDIN,Y). COMPORTEMENT MECANIQUE DES CHAPES D'ETANCHEITE EN BITUMES MODIFIES (DENIC,N). FORCED VIBRATION TESTS ON BITUMEN - AND POLYMER-BITUMEN MEMBRANES TO DETERMINE THEIR ESSENTIAL PROPERTIES (FRITZ,HW). MODIFICATION OF AN ORDINARY DISTILLATION BITUMEN FOR USING IN ROOFING AND WATERPROOFING (RODRIGEZ DE SANCHO,I ; BLANCO FERNANDEZ,M). ETUDE DU COMPORTEMENT DES MELANGES BITUMES SBS EN FONCTION DE LA CONSTITUTION DU BITUME ET DE LA NATURE DE POLYMERE (STAWIARSKI,A). INVESTIGATIONS OF THE BEHAVIOUR OF GUSSASPHALT CONTAINING POLYMER-MODIFIED BITUMEN (VATER,EJ). B - METHODES SIGNIFICATIVES POUR LES ENROBES ET AUTRES MATERIAUX POUR LA TECHNIQUE ROUTIERE QUI CONTIENT LES COMMUNICATIONS SUIVANTES : METHODES SIGNIFICATIVES POUR LES ENROBES, LES ENROBES DRAINANTS (GORDILLO,J). ELABORATION OF SPECIFICATIONS FOR POLYMER MODIFIED BINDERS FOR SURFACE DRESSINGS (RUTTGERS,G). SUBJECT REPORT (SAMANOS,J). EVALUATION OF BRITTLENE TEMPERATURE THRU PLATE COHESION TEST (BOUSSAD,K ; MULLER,JM ; TOUZARD,B). DROPPING TEMPERATURE OF CHIPS IN THE COLD (KST) AND IN THE HEAT (WST) (BREUER,JU). SPECIFIC TEST TO EVALUATE THE PERFORMANCES OF SURFACE DRESSINGS (FORTIN,Y). POLYMERMODIFIED BINDERS AND THE MARSHALL-TEST (HARDERS,O). SURFACE DRESSINGS WITH PMB, ESPECIALLY SBR. VIALIT TEST AFTER FROST/THAW (LADEHOFF,L). MATERIAUX BITUMINEUX MODIFIES POUR LA CONSTRUCTION ROUTIERE. EXPERIENCES ET ETUDES REALISEES PAR LA SOCIETE AUTOSTRADE (LUMINARI,M). ESSAIS SUR LES BETONS A BASE DE BITUME-POLYMERE (PIGOIS,M). QUE FAUT-IL SAVOIR SUR LA COMPOSITION CHIMIQUE DU BITUME LORS DE L'UTILISATION DES BITUMES MODIFIES PAR DES POLYMERES DANS LA PRODUCTION DES BETONS BITUMEUX ? (RAMLJAK,Z). STATIC LOADING TESTS FOR ASPHALTIC CONCRETE (VONK,WC). INVESTIGATION ON SLURRY SEAL CONSISTENCY BY THE MODIFIED WET-TRACK-ABRASION-TEST METHOD (WORTELBOER,J). CONCLUSIONS (NEUMANN,HJ). (VOIR FICHE GENERALE DIRR 122785).
Evaluation of biological width around implants inserted in native alveolar crest bone (2009)

Aim Biological width represents the distance necessary for a healthy existence of bone and soft tissue around teeth and/or implants. The mean value is about 3 mm and if it is compromised there is a greater probability of resorption of interproximal alveolar crest. Materials and methods A retrospective study was performed on a series of 234 Spiral family Implants (SFIs) in order to detect the minimal biological width between implants or between tooth and fixture that does not determine a crestal bone resorption. The series was split in two groups: distances ≤1.8 mm and ≥ 1.9 mm. Lost implants and crestal bone resorption around implant neck were considered as survival and success outcome and several clinical variables were matched against them by using Kaplan-Meyer and chi-square tests. Results No statistical significant difference was demonstrated between the two groups (i.e. ≤1.8 mm and ≥1.9 mm), but a clear trend over time was detected with a greater crestal bone resorption for distances ≤1.8 mm. Conclusion The data confirm the importance of a correct IID and add new information as regard fixtures with reverse conical neck which permits the use of a reduced IID.
Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene. (1996)

We report the isolation of 10 differentially expressed cDNAs in the process of apoptosis induced by the p53 tamor suppressor. As a global analytical method, we performed a differential display of mRNA between mouse M1 myeloid leukemia cells and derived clone LTR6 cells, which contain a stably transfected temperature-sensitive mutant of p53. At 32 degrees C wild-type p53 function is activated in LTR6 cells, resulting in programmed cell death. Eight genes are activated (TSAP; tumor suppressor activated pathway), and two are inhibited (TSIP, tumor suppressor inhibited pathway) in their expression. None of the 10 sequences has hitherto been recognized as part of the p53 signaling pathway. Three TSAPs are homologous to known genes. TSAP1 corresponds to phospholipase C beta 4. TSAP2 has a conserved domain homologous to a multiple endocrine neoplasia I (ZFM1) candidate gene. TSAP3 is the mouse homologue of the Drosophila seven in absentia gene. These data provide novel molecules involved in the pathway of wild-type p53 activation. They establish a functional link between a homologue of a conserved developmental Drosophila gene and signal transduction in tumor suppression leading to programmed cell death.
Delivering safer immunotherapies for cancer (2017)

Cancer immunotherapy is now a powerful clinical reality, with a steady progression of new drug approvals and a massive pipeline of additional treatments in clinical and preclinical development. However, modulation of the immune system can be a double-edged sword: Drugs that activate immune effectors are prone to serious non-specific systemic inflammation and autoimmune side effects. Drug delivery technologies have an important role to play in harnessing the power of immune therapeutics while avoiding on-target/off-tumor toxicities. Here we review mechanisms of toxicity for clinically-relevant immunotherapeutics, and discuss approaches based in drug delivery technology to enhance the safety and potency of these treatments. These include strategies to merge drug delivery with adoptive cellular therapies, targeting immunotherapies to tumors or select immune cells, and localizing therapeutics intratumorally. Rational design employing lessons learned from the drug delivery and nanomedicine fields has the potential to facilitate immunotherapy reaching its full potential.
Construction of Disease-specific Cytokine Profiles by Associating Disease Genes with Immune Responses (2021)

Abstract The pathogenesis of many inflammatory diseases is a coordinated process involving metabolic dysfunctions and immune response—usually modulated by the production of cytokines and associated inflammatory molecules. In this work, we seek to understand how genes involved in pathogenesis which are often not associated with the immune system in an obvious way communicate with the immune system. We have embedded a network of human protein-protein interactions (PPI) from the STRING database with 14,707 human genes using feature learning that captures high confidence edges. We have found that our predicted Association Scores derived from the features extracted from STRING’s high confidence edges are useful for predicting novel connections between genes, thus enabling the construction of a full map of predicted associations for all possible pairs between 14,707 human genes. In particular, we analyzed the pattern of associations for 126 cytokines and found that the six patterns of cytokine interaction with human genes are consistent with their functional classifications. In order to define the disease-specific roles of cytokines we have collected gene sets for 11,944 diseases from DisGeNET. We used these gene sets to predict disease-specific gene associations with cytokines by calculating the normalized average Association Scores between disease-associated gene sets and the 126 cytokines; this creates a unique profile of inflammatory genes (both known and predicted) for each disease. We validated our predicted cytokine associations by comparing them to known associations for 171 diseases. The predicted cytokine profiles correlate (p-value&lt;0.05) with the known ones in 147 diseases. We further characterized the profiles of each disease by calculating an “Inflammation Score” that summarizes different modes of immune responses. Finally, by analyzing subnetworks formed between disease-specific pathogenesis genes, hormones, receptors, and cytokines, we identified the key genes responsible for interactions between pathogenesis and inflammatory responses. These genes and the corresponding cytokines used by different immune disorders suggest unique targets for drug discovery.
High‐dose oral dextromethorphan versus placebo in painful diabetic neuropathy and postherpetic neuralgia (1997)

N-methyl-D-aspartate (NMDA) receptor antagonists relieve neuropathic pain in animal models, but side effects of dissociative anesthetic channel blockers, such as ketamine, have discouraged clinical application. Based on the hypothesis that low-affinity NMDA channel blockers might have a better therapeutic ratio, we carried out two randomized, double-blind, crossover trials comparing six weeks of oral dextromethorphan to placebo in two groups, made up of 14 patients with painful distal symmetrical diabetic neuropathy and 18 with postherpetic neuralgia. Thirteen patients with each diagnosis completed the comparison. Dosage was titrated in each patient to the highest level reached without disrupting normal activities; mean doses were 381 mg/day in diabetics and 439 mg/day in postherpetic neuralgia patients. In diabetic neuropathy, dextromethorphan decreased pain by a mean of 24% (95% CI: 6% to 42%, p = 0.01), relative to placebo. In postherpetic neuralgia, dextromethorphan did not reduce pain (95% CI: 10% decrease in pain to 14% increase in pain, p = 0.72). Five of 31 patients who took dextromethorphan dropped out due to sedation or ataxia during dose escalation, but the remaining patients all reached a reasonably well-tolerated maintenance dose. We conclude that dextromethorphan or other low-affinity NMDA channel blockers may have promise in the treatment of painful diabetic neuropathy.
Cobalt-60 facilities available for hardness assurance testing (1986)

This report contains a list of cobalt-60 gamma-ray irradiation facilities that are available for hardness assurance testing of electronic devices.
Purification and properties of a diisopropyl‐fluorophosphatase from squid Todarodes pacificus steenstrup (1993)

A diisopropyl-fluorophosphatase (DFPase) was purified from brain and ganglia of squid Todarodes pacificus steenstrup. The DFPase had a preference in hydrolysis toward diisopropylphosphorofluoridate (DFP). It also was able to hydrolyze O-1,2,2-trimethylpropyl methylphosphofluoridate (soman) and O-isopropyl methylphosphonofluoridate (sarin) at nearly equal hydrolytic rates but only 1/10 that of DFP. The hydrolytic activity toward diethyl-p-nitrophenylphosphate (paraoxon) was very low compared with DFP, soman, and sarin. The DFPase was purified 330-fold to a specific activity of 18,300 n mol/min/mg protein. Its molecular weight was 34,000 dalton determined by gel-filtration chromatography. Mn2+ stimulation of the DFPase was not observed when DFP and soman were the substrates, but with sarin, the rate increased onefold in the presence of 1.0 mM of Mn2+. Ethylenediamine tetraacetic acid disodium (EDTA-Na2) at 0.05 M inhibited the DFPase activity about 30%. It could be concluded that this DFPase belongs to the squid-type DFPase.
Multiform Sulfur Adsorption Centers and Copper-Terminated Active Sites of Nano-CuS for Efficient Elemental Mercury Capture from Coal Combustion Flue Gas (2018)

Nanostructured copper sulfide synthesized with the assistance of surfactant with nanoscale particle size and high Brunauer-Emmett-Teller surface area was for the first time applied for the capture of elemental mercury (Hg<sup>0</sup>) from coal combustion flue gas. The optimal operation temperature of nano-CuS for Hg<sup>0</sup> adsorption is 75 °C, which indicates that injection of the sorbent between the wet flue gas desulfurization and the wet electrostatic precipitator systems is feasible. This assures that the sorbent is free of the adverse influence of nitrogen oxides. Oxygen (O<sub>2</sub>) and sulfur dioxide exerted a slight influence on Hg<sup>0</sup> adsorption over the nano-CuS. Water vapor was shown to moderately suppress Hg<sup>0</sup> capture efficiency via competitive adsorption. The simulated adsorption capacities of nano-CuS for Hg<sup>0</sup> under pure nitrogen (N<sub>2</sub>), N<sub>2</sub> + 4% O<sub>2</sub>, and simulated flue gas reached 122.40, 112.06, and 89.43 mgHg<sup>0</sup>/g nano-CuS, respectively. Compared to those of traditional commercial activated carbons and metal sulfides, the simulated adsorption capacities of Hg<sup>0</sup> over the nano-CuS are at least an order of magnitude higher. Moreover, with only 5 mg loaded in a fixed-bed reactor, the Hg<sup>0</sup> adsorption rate reached 11.93-13.56 μg/g min over nano-CuS. This extremely speedy rate makes nano-CuS promising for a future sorbent injection technique. The anisotropic growth of nano-CuS was confirmed by X-ray diffraction analysis and provided a fundamental aspect for nano-CuS surface reconstruction and polysulfide formation. Further X-ray photoelectron spectroscopy and Hg<sup>0</sup> temperature-programmed desorption tests showed that the active polysulfide, S-S dimers, and copper-terminated sites contributed primarily to the extremely high Hg<sup>0</sup> adsorption capacity and rate. With these advantages, nano-CuS appears to be a highly promising alternative to traditional sorbents for Hg<sup>0</sup> capture from coal combustion flue gas.
Author response: Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination (2020)

Excitability gradients in heart tissue, imposed by structured sub-threshold optogenetic stimulation, induce drift and termination of spiral waves, thus providing an explanation for successful optogenetic defibrillation in small animal hearts.
Exopolysaccharides Produced by Phytopathogenic Pseudomonas syringae Pathovars in Infected Leaves of Susceptible Hosts (1989)

Bacterial exopolysaccharide (EPS) was extracted from infected leaves of several host plants inoculated with phytopathogenic strains of Pseudomonas syringae pathovars. Extraction was by a facilitated diffusion procedure or by collection of intercellular fluid using a centrifugation method. The extracted EPS was purified and characterized. All bacterial pathogens which induced watersoaked lesions on their host leaves, a characteristic of most members of this bacterial group, were found to produce alginic acid (a polymer consisting of varying ratios of mannuronic and guluronic acids). Only trace amounts of bacterial EPS could be isolated from leaves inoculated with a pathovar (pv. syringae) which does not induce the formation of lesions with a watersoaked appearance. Guluronic acid was either present in very low amounts or absent in the alginic acid preparations. All bacterial alginates were acetylated (7-11%). Levan (a fructan) was apparently not produced as an EPS in vivo by any of the pathogens tested.
ChemInform Abstract: Molecular Recognition with Lanthanoid Complex‐Type Receptors: A Review (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vibrational Properties of [FeH(N2)(depe)2]+ and [FeCl(N2)(depe)2]+]: Dinitrogen Bonding in the Low Activation Limit (2002)

The vibrational properties of the two octahedral FeII dinitrogen complexes [FeH(N2)(depe)2]+ (1) and [FeCl(N2)(depe)2]+ (2, depe = 1, 2-bis(diethylphosphino)ethane) are investigated with the help of infrared and Raman spectroscopies. Vibrational data are evaluated with a Quantum Chemistry Assisted Normal Coordinate Analysis (QCA-NCA; N. Lehnert, F. Tuczek, Inorg. Chem.1999, 38, 1659). In agreement with high values found for ν(NN) and the corresponding force constants f(NN), the N2 ligands in compounds 1 and 2 are non-activated which corresponds to the observation that N2 is not protonable in FeII systems. Taking into account the short Fe-N bond lengths, the values of the Fe-N stretching force constants (2.55mdyn/Å for 1 and 2.58mdyn/Å for 2) are found to be compatible with those of other FeII low-spin compounds coordinated to backbonding N-coordinating ligands. The force fields obtained for the Fe-N2 units of 1 and 2 are almost identical although the thermal stability of 1 and 2 with respect to loss of N2 is different. This indicates that the zero-point vibrational levels are unaffected by possible ground-state level crossing processes occuring at larger Fe-N bond lengths, as observed for 2 (O. Franke, B. E. Wiesler, N. Lehnert, C. Näther, V. Ksenofontov, J. Neuhausen, F. Tuczek, Inorg. Chem. 2002, 41, 3491). Schwingungseigenschaften von [FeH(N2)(depe)2]+ und [FeCl(N2)(depe)2]+: Bindung von Distickstoff im niederen Aktivierungsbereich Die Schwingungseigenschaften der zwei okta edrischen Stickstoff-Komplexe [FeH(N2)(depe)2]+ (1) und [FeCl(N2)(depe)2]+ (2) werden mit Hilfe der IR- und Raman-Spektroskopie untersucht. Die Schwingungsdaten werden ausgewertet mit einer quantenchemisch unterstützten Normalkoordinatenanalyse (QCA-NCA, N. Lehnert, F. Tuczek, Inorg. Chem. 1999, 38, 1659). In Übereinstimmung mit den hohen Werten, die für ν(NN) und die entsprechenden Kraftkonstanten f(NN) gefunden wurden, sind die N2-Liganden in den Verbindungen 1 und 2 nicht aktiviert, was im Einklang steht mit der Beobachtung, dass N2 in FeII-Systemen nicht protonierbar ist. Unter Berücksichtigung der kurzen Fe-N-Bindungslänge liegen die Werte der Fe-N-Kraftkonstanten (2.55mdyn/Å für 1 und 2.58mdyn/Å für 2) im gleichen Bereich wie diejeniger anderer FeII low spin-Systeme, an denen rückbindende Stickstoff-Liganden über Stickstoff koordiniert sind. Die Kraftfelder, die für die Fe-N2-Einheit von 1 und 2 erhalten wurden, sind beinahe identisch, obwohl die thermische Stabilität von 1 und 2 im Hinblick auf den Verlust von N2 unterschiedlich ist. Dies zeigt, dass die Nullpunktsenergien unbeeinflusst sind von möglichen Grundzustandsüberschneidungen, die bei grösseren Fe-N-Bindungslängen auftreten, wie bei Verbindung 2 beobachtet (O. Franke, B. E. Wiesler, N. Lehnert, C. Näther, V. Ksenofontov, J. Neuhausen, F. Tuczek, Inorg. Chem. 2002, 41, 3491).
An integrated single-switch approach to improve harmonic performance of standard PWM adjustable speed drives (2003)

In this paper, an integrated single-switch approach to improve the harmonic performance of standard PWM adjustable speed drives (ASD) is presented. The approach is essentially an add-on solution to a standard ASD topology. The approach is based on circulating a third harmonic current to reduce the harmonics of the line current. The dynamic braking chopper available in standard ASDs is used to control the amplitude of the third harmonic circulating current. Analysis, design and simulations are presented to determine the performance of the proposed scheme with different line impedances and with and without DC-link inductance in the ASD. Utility input current distortion well below 15% is obtained. This paper also presents how this new approach is capable of reducing the harmonic distortion in multiple drives. The paper includes experimental results using a 480 V, 10 kW commercial adjustable speed drive retrofitted with the proposed approach.
Evaluation of the Major Steps in the Conventional Protocol for the Alkaline Comet Assay (2019)

Single cell gel electrophoresis, also known as the comet assay, has become a widespread DNA damage assessment tool due to its sensitivity, adaptability, low cost, ease of use, and reliability. Despite these benefits, this assay has shortcomings, such as long assay running time, the manipulation of multiple slides, individually, through numerous process steps, the challenge of working in a darkened environment, and reportedly considerable inter- and intra-laboratory variation. All researchers typically perform the comet assay based upon a common core approach; however, it appears that some steps in this core have little proven basis, and may exist, partly, out of convenience, or dogma. The aim of this study was to critically re-evaluate key steps in the comet assay, using our laboratory’s protocol as a model, firstly to understand the scientific basis for why certain steps in the protocol are performed in a particular manner, and secondly to simplify the assay, and decrease the cost and run time. Here, the shelf life of the lysis and neutralization buffers, the effect of temperature and incubation period during the lysis step, the necessity for drying the slides between the electrophoresis and staining step, and the need to perform the sample workup and electrophoresis steps under subdued light were all evaluated.
Portable 532 nm Iodine-Stabilized DPSS Laser for Length Standard (2012)

A diode-pumped solid-state (DPSS) laser, such as a Nd:YAG green laser, has become smaller in size , lower in cost and higher in performance. Therefore, the DPSS lasers are widely used in many industries. For a laser interferometers and secondly length standards, stable light sources are in demand. We have developed 532 nm iodine-stabilized DPSS lasers used for the applications. The lasers have following features ; compact design (D 280×W 170×H 120 mm), high power (3 mW) , high stability ( &lt; 1×10 -1 0 : allann deviation k=1 at τ=1 sec), and easy operation.
Two novel mutations found in a patient with 17 ?-hydroxylase enzyme deficiency (2004)

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders caused by steroidogenic enzyme gene defects involved in biosynthesis of cortisol and aldosterone. CAH due to 17 α-hydroxylase deficiency (17OHD) is a rare disorder associated with hypertension. The 17 α-hydroxylase is necessary for the biosynthesis of adrenal glucocorticoids and androgens. The enzyme deficiency in adrenals causes decreased cortisol and sex steroid production. Adrenals and gonads share the 17 α-hydroxylase defect. Affected females present with primary amenorrhea and lack of development of secondary sex characteristics. In males, it is characterized by reduced virilization causing male pseudohermaphroditism. Increased ACTH owing to low cortisol levels increases the synthesis of 11-deoxycorticosterone (DOC) and corticosterone resulting in sodium retention, hypertension, hypokalemia and suppressed PRA and aldosterone. The 17a-hydroxylase has both 17a-hydroxylase and 17,20-lyase activity. The gene for P450c17 (CYP17) maps to chromosome 10q24.3. Mutations of 17 α-hydroxylase have been documented in the cytochrome P450c17. Here, we are presenting a female patient with CAH owing to 17OHD. This patient presented at the age of 31.5 year and was initially diagnosed at the age of 15 elsewhere, when she demonstrated hypertension (148/99), hypokalemia, and delayed puberty (Tanner 2 breast and pubic hair, and infantile genitalia). Her plasma cortisol level was 0 before ACTH stimulation and 2.4 ug/dl after ACTH suggesting a cortisol synthesis defect. The level of DOC and corticosterone were elevated suggesting the 17OHD. Her other hormonal evaluation indicated that there was also androgen defect. She was placed on glucocorticoid treatment and sex-steroids. DNA sequencing of her CYP17 gene revealed a maternal heterozygous mutation in exon 2 (R125Q) and an exon 8 (R416H) (the father was not available for analysis). These are new mutations in the CYP17 gene. Am J Hypertens (2004) 17, 154A–154A; doi: 10.1016/j.amjhyper.2004.03.403