gebhart/patrepeval huggingface dataset:
Virtualised Trusted Computing Platform for Adaptive Security Enforcement of Web Services Interactions (2007)

Security enforcement framework is an important aspect of any distributed system. With new requirements imposed by SOA-based business models, adaptive security enforcement on the application level becomes even more important. Our work on the enforcement framework to date has resulted in a comprehensive middleware-based solution leveraging on Web services technologies. However, potential merits of hardware-based solutions to further secure application exposure have not been considered so far. This paper describes a method for combining software resource level security features offered by Web services technologies, with the hardware-based security mechanisms offered by trusted computing platform and system virtualisation approaches. In particular, we propose trust-based architecture for protecting the enforcement middleware deployed at the policy enforcement endpoints of Web and grid services. The main motivation is to additionally secure execution environment of the applications, by providing virtual machine level separation that maps from logical domains imposed by Web services level enforcement policies.
Synthesis, vibrational and tin-119 Moessbauer spectra, and crystal and molecular structure of tris(dimethyltin(IV) bis(orthophosphate) octahydrate (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, vibrational and tin-119 Moessbauer spectra, and crystal and molecular structure of tris(dimethyltin(IV) bis(orthophosphate) octahydrateJ. P. Ashmore, T. Chivers, K. A. Kerr, and J. H. G. Van RoodeCite this: Inorg. Chem. 1977, 16, 1, 191–197Publication Date (Print):January 1, 1977Publication History Published online1 May 2002Published inissue 1 January 1977https://pubs.acs.org/doi/10.1021/ic50167a040https://doi.org/10.1021/ic50167a040research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Low-Complexity Large MIMO Detection via Layered Belief Propagation in Beam Domain (2021)

In large multi-user multi-input multi-output systems, the computational cost and circuit scale of base stations (BSs) are effectively reduced using two-stage signal processing consisting of a slow varying outer beamformer (OBF) based on long-term channel statistics and group-specific multi-user detection for instantaneous channel variations. However, the dimensionality reduction of the group-specific beam-domain channel based on the OBF causes significant performance degradation in the subsequent spatial-filtering detection. To compensate for this drawback, this paper introduces a novel layered belief propagation (BP) detector with a concatenated structure of beam- and antenna-domain BP layers for post-stage OBF processing. The proposed detector is designed for improving the convergence of iterative detection by suppressing intra- and inter-group interference in stages. The layered structure provides the advantages of both beam and antenna domains while maintaining low signal-processing complexity. Numerical results show the validity of our proposed method in terms of the bit error rate performance in both the uncoded and coded cases and the computational complexity.
RADIATION YIELDS OF TRIPLET MOLECULES IN FROZEN SOLUTIONS. (1972)

Congenital diseases of the eyes is the most frequent cause of vision reduction in children and one of the major causes of invalidity for poor sight. The aim of the present study was analysis of the causes of congenital ocular diseases in children in Kazakhstan. Results of prophylactic examinations at some rural districts of the republic evidence that refraction abnormalities rank first in the structure of congenital ocular diseases, oculomotor system abnormalities second, and defects of the eyelids and lacrimal tract, third. Congenital diseases of the eye make up 29-42 percent of all ocular diseases in children. Hospital records evidence a 45 percent incidence of congenital diseases of the eye. Lenticular abnormalities rank first, oculomotor system pathology second, and eyelid diseases third in the structure of congenital diseases of the eyes.
Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse. (1991)

Polycystic kidney disease in the C57BL/6J (cpk) mouse is an autosomal recessive disorder which leads to the rapid development of renal cysts and kidney failure during the first 3 to 4 postnatal weeks. Previously, we showed that the cystic kidneys of affected mice have abnormally elevated levels of c-myc mRNA. In the study presented here, it is shown that mRNAs for the proto-oncogenes c-fos and c-Kiras, as well as c-myc, are markedly elevated in cystic kidneys, suggesting that there is a more general abnormality in gene expression associated with the disease. It is also evident that there are two stages to this abnormal proto-oncogene expression. In the first stage, which occurs up through the second postnatal week, there are modest increases in proto-oncogene mRNA which parallel the increased cell proliferation that accompanies cyst growth at this time. In the second stage, which occurs after the second postnatal week, there are markedly elevated levels of proto-oncogene mRNA that are seen at a time when cell proliferation is declining. The development of this latter stage suggests either that there is a fundamental abnormality intrinsic to polycystic kidneys that leads to uncontrolled proto-oncogene expression later in disease progression or that there is a secondary response in the kidney to the progressive renal failure.
An international validation study of two achievement goal measures in a pharmacy education context (2014)

Background: Achievement goal theory helps us understand what motivates students to participate in educational activities. However, measuring achievement goals in a precise manner is problematic. Elliot and McGregor's Achievement Goal Questionnaire (AGQ) and Elliot and Murayama's revised Achievement Goal Questionnaire (AGQ-R) are widely used to assess students' achievement goals. Both instruments were developed and validated using undergraduate psychology students in the USA. Methods: In this study, our aims were to first of all, assess the construct validity of both questionnaires using a cohort of Australian pharmacy students and, subsequently, to test the generalizability and replicability of these tools more widely in schools of pharmacy in other English-speaking countries. The AGQ and the AGQ-R were administered during tutorial class time. Confirmatory factor analysis procedures, using AMOS 19 software, were performed to determine model fit. Results: In contrast to the scale developers' findings, confirmatory factor analysis supported a superior model fit for the AGQ compared with the AGQ-R, in all countries under study. Conclusion: Validating measures of achievement goal motivation for use in pharmacy education is necessary and has implications for future research. Based on these results, the AGQ will be used to conduct future cross-sectional and longitudinal analyses of the achievement goals of undergraduate pharmacy students from these countries. Keyword: confirmatory factor analysis, achievement goal theory, pharmacy education
Kernels, backpropagation, and regularized cross-validation (2016)

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Space Vector Modulation for Circulating Current Suppression Using Deadbeat Control Strategy in Parallel Three-Level Neutral-Clamped Inverters (2016)

Parallel three-level T-type inverters (3LT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> Is) can effectively increase the power rating. However, when multiple 3LT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> Is are connected to a single dc bus, the zero-sequence circulating current (ZSCC) will occur. The ZSCC will distort the output currents and increase the system loss. To overcome this drawback, this paper proposes a novel deadbeat control scheme for the ZSCC suppression. A generalized model for analyzing ZSCC in parallel 3LT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> Is is developed for designing the deadbeat control method. The proposed deadbeat control scheme is realized by real time adjusting the dwell time of small vectors in each space vector modulation. Compared to the conventional PI control method, the influence of different sector is eliminated, thus, improving the output current waveform and reducing the ZSCC. The effectiveness of the proposed method is verified by simulation and experiments.
An EV battery charger with power factor corrected bridgeless zeta converter topology (2016)

An EV (Electric Vehicle) is becoming more popular these days in transport sector due to its environment friendly operation as well as availability at reduced cost. The battery charging process is the prominent matter of concern in an EV because of power quality issues in the input current drawn by the charger. These issues are generated mainly because of the nonlinear nature of the diode bridge rectifier (DBR), used at the input side of the charger for AC-DC conversion. The abovementioned problem is minimized if the DBR is eliminated at the input, along with added advantage of reduced conduction loss in the circuit. Therefore, this paper proposes a bridgeless isolated PFC (Power Factor Corrected) based EV battery charger with a zeta converter topology which uses constant current/constant voltage mode control for the battery charging. The proposed bridgeless converter is designed to follow IEC-61000-3-2 PQ (Power Quality) standard i.e. it draws a perfect sinusoidal input current with low THD from AC mains with all the advantages of zeta converter topology like low output ripple voltage, a non-inverted output, stable output response and effective control. Therefore, the overall efficiency is improved for the proposed front end bridgeless converter. MATLAB/Simulink based model is developed which is used to verify the performance of the proposed bridgeless zeta converter at rated condition as well as fluctuations in the supply voltage. The converter' performance is evaluated with a 48V 100Ah lead acid battery being used in EV which exhibit an improved power quality indices for the source current that is well within international PQ limits.
Mathematical model of electrostatic precipitation (revision 2). Report for Jan 76-Dec 78 (1980)

The report describes modifications to the EPA/Southern Research Institute computer model of electrostatic precipitation (ESP). The modifications include a new semi-empirical approximation procedure for predicting electrical conditions in an ESP. Comparisons between the results from the approximation procedure and more exact procedures are presented. A new integration procedure for calculating particle charge is also presented. Complete Fortran listings of the revised ESP model and the new subprograms are provided. Example problems are included. The modified model requires significantly less computer time than does the earlier model. Comparisons of results obtained using the earlier and the modified models over a wide range of possible ESP geometries and electrical operating points indicate that for practical purposes the modified model can be used in place of the more rigorous earlier model.
Tautomerism in 4-Hydroxypyrimidine, S-Methyl-2-thiouracil, and 2-Thiouracil (2010)

The keto-enol tautomerism of 4-hydroxypyrimidine and of the related molecules S-methyl-2-thiouracil and 2-thiouracil has been investigated using synchrotron-based techniques. The populations of the constituent tautomers and thermodynamic parameters have been obtained by analysis of core-level photoemission spectra. The effect of substituents on the stability of tautomers has been revealed. Attaching additional OH (or SH) groups to the aromatic ring stabilizes the dioxo (or oxo-thione) forms. However, substitution of hydrogen in position 2 by an S-CH(3) group (that is, in going from 4-hydroxypyrimidine to S-methyl-2-thiouracil) does not significantly affect the tautomeric equilibrium.
Non–Multiple Sclerosis Central Nervous System Inflammatory Disease (2021)

Abstract Multiple sclerosis (MS) is the most common inflammatory central nervous system (CNS) disease. Yet, clinicians should be cognizant of other demyelinating and nondemyelinating CNS inflammatory diseases, some of which mimic MS. This chapter reviews the spectrum of non-MS CNS inflammatory diseases and MS mimics.
Efeitos clínicos, microbiológicos e imunológicos da terapia fotodinâmica antimicrobiana no tratamento não cirúrgico da periodontite agressiva: um estudo clínico do tipo boca-dividida, controlado, aleatorizado e duplo-cego (2014)

O tratamento da Periodontite Agressiva (PA) representa um desafio para os clnicos, pois no existem protocolos padronizados para um controle eficiente da doena. Este estudo clnico controlado, aleatrio e duplo-cego avaliou o efeito de mltiplas aplicaes da Terapia Fotodinmica antimicrobiana (TFDa) como adjuvante ao tratamento periodontal no cirrgico (TPnc) em pacientes diagnosticados com PA. Utilizando um modelo de estudo do tipo boca dividida, 20 pacientes com diagnstico clnico de PA foram tratados com TFDa (Grupo Teste) associada raspagem e alisamento radicular (RAR) ou apenas RAR (Grupo Controle). As aplicaes da TFDa foram realizadas em 4 episdios (dias 0, 2, 7 e 14). Todos os pacientes foram acompanhados por 90 dias. Os seguintes parmetros clnicos, microbiolgicos e imunolgicos foram analisados: i) profundidade de bolsa sondagem (PS) e nvel de insero clnico (NCI); ii) contagem de 40 espcies subgengivais em amostras de placa bacteriana (checkerboard DNA-DNA hybridization); iii) avaliao dos nveis de Interleucina (IL)-1, IL-10 e Fator de Necrose Tumoral alfa (TNF-) no fluido crevicular gengival (Luminex). Os dados obtidos foram estatisticamente analisados. Na anlise de bolsas periodontais profundas (PS inicial 7mm), o Grupo Teste apresentou, aos 90 dias, reduo de PS (-3,96 mm 0,83) e ganho de insero clnica (2,77 mm 1,05) significativamente maiores (p < 0,05) que aqueles do Grupo Controle (PS = -2,56 0,72; NCI = 1,75 1,07). Foi constatado, tambm, um nmero significativamente menor de bolsas periodontais residuais (PS 5mm) no Grupo Teste quando comparado ao Grupo Controle aos 90 dias (p < 0,05). Na anlise microbiolgica, o Grupo Teste apresentou propores significativamente menores de espcies microbianas dos complexos vermelho e laranja, bem como maiores propores de espcies do complexo azul quando comparado ao Grupo Controle aos 90 dias (p < 0,05). Na anlise imunolgica, observou-se nveis de IL-1 no Grupo Controle significativamente maiores que aqueles do Grupo Teste aos 14, 30 e 90 dias (p < 0,05). Em relao aos nveis de IL-10, apenas o Grupo Teste apresentou valores significativamente maiores (p < 0,05) que aqueles do baseline aos 30 dias. Para TNF-, no foi possvel observar diferenas significativas nas comparaes inter e intragrupos em todos os perodos experimentais. O Grupo Teste apresentou razo IL-1/IL-10 significativamente menor que aquela do Grupo Controle aos 90 dias (p < 0,05). Pode-se concluir que a utilizao de aplicaes mltiplas da TFDa como recurso adjuvante TPnc de pacientes com PA: i) melhora significativamente os parmetros clnicos periodontais, reduzindo a necessidade de tratamentos periodontais adicionais aos 90 dias; ii) elimina de forma mais eficaz periodontopatgenos dos complexos vermelho e laranja; iii) melhora os parmetros imunoinflamatrios, reduzindo a concentrao de citocinas proinflamatrias e aumentando os nveis de citocinas anti-inflamatrias.
cDNA Cloning of Human Retinoic Acid-metabolizing Enzyme (hP450RAI) Identifies a Novel Family of Cytochromes P450 (CYP26) (1997)

Retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA play important roles in regulating gene expression, through interactions with nuclear receptors, during embryonic development and in the maintenance of adult epithelial tissues (Chambon, P. (1995) Rec. Prog. Horm. Res. 50, 317-32; Mangelsdorf, D. J., and Evans, R. M. (1995) Cell 83, 841-850; Petkovich, M. (1992) Annu. Rev. Nutr. 12, 443-471). Evidence suggests that 4-hydroxylation of RA inside the target cell limits its biological activity and initiates a degradative process of RA leading to its eventual elimination. However, 18-hydroxylation and glucuronidation may also be important steps in this process. In this paper, we describe the cloning and characterization of the first mammalian retinoic acid-inducible retinoic acid-metabolizing cytochrome P450 (hP450RAI), which belongs to a novel class of cytochromes (CYP26). We demonstrate that hP450RAI is responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. We also show that hP450RAI mRNA expression is highly induced by RA in certain human tumor cell lines and further show that RA-inducible RA metabolism may correlate with P450RAI expression. We conclude that this enzyme plays a key role in RA metabolism, functioning in a feedback loop where RA levels are controlled in an autoregulatory manner.
Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity (2015)

The ability of cellular fibronectin, found in the vessel wall in a fibrillar conformation, to regulate platelet functions and trigger thrombus formation remains largely unknown. In this study, we evaluated how parietal cellular fibronectin can modulate platelet responses under flow conditions. A fibrillar network was formed by mechanically stretching immobilised dimeric cellular fibronectin. Perfusion of anticoagulated whole blood over this surface resulted in efficient platelet adhesion and thrombus growth. The initial steps of platelet adhesion and activation, as evidenced by filopodia extension and an increase in intracellular calcium levels (419 ± 29 nmol/l), were dependent on integrins α5β1 and αIIbβ3. Subsequent thrombus growth was mediated by these integrins together with the GPIb-V-IX complex, GPVI and Toll-like receptor 4. The involvement of Toll-like receptor 4 could be conveyed via its binding to the EDA region of cellular fibronectin. Upon thrombus formation, the platelets became procoagulant and generated fibrin as revealed by video-microscopy. This work provides evidence that fibrillar cellular fibronectin is a strong thrombogenic surface which supports efficient platelet adhesion, activation, aggregation and procoagulant activity through the interplay of a series of receptors including integrins α5β1 and αIIbβ3, the GPIb-V-IX complex, GPVI and Toll-like receptor 4.
Boosting the value of insoluble dietary fiber to increase gut fermentability through food processing (2021)

Insoluble dietary fibers are typically known to be poorly fermented in the large intestine. However, their value may be high as evidence shows that important butyrogenic bacteria preferentially utilize insoluble substrates to support their energy needs. The objective of this study was to increase fermentability of an insoluble bran fiber (pearl millet) while keeping it mostly insoluble to promote bacteria in the community that rely on fermentable insoluble dietary fibers. Following pretests with different processing methods, a combination of microwave and enzymatic treatments were applied to isolated pearl millet fiber to increase its accessibility of gut bacteria. <i>In vitro</i> human fecal fermentation was conducted and analyses were made for short chain fatty acids and microbiota changes. Combined microwave and enzymatic processing increased the amount of insoluble fiber fermented <i>in vitro</i> from 36 to 59% of total dietary fiber, with a minor increase in soluble fiber (8%). Microwave/enzymatic processing doubled butyrate production and almost tripled acetate production at 6 h fermentation compared to the native millet fiber. 16S rRNA gene sequencing showed that the processing promoted a significant increase in Firmicutes/Bacteroidetes ratio compared to the native fiber with relative abundance increases in <i>Blautia</i> and <i>Copprococcus</i> genera and a decrease in Bacteroidetes. Overall, these data show that processing techniques can be used to increase the value of insoluble fiber, presumably by increasing accessibility of the fiber to degrading bacteria, and to support Firmicutes that preferentially compete on insoluble fibers.
Most Potential Linear B Cell Epitopes of Env Glycoproteins of Feline Immunodeficiency Virus Are Immunogenically Silent in Infected Cats (1997)

A battery of sixty-six 20- to 23-amino acid synthetic peptides, partially overlapping by 10-12 amino acids, spanning the entire sequence of the envelope (Env) glycoproteins of the Petaluma isolate of feline immunodeficiency virus (FIV-Pet), has been used to map Env linear B cell epitopes. By screening FIV-infected cat sera for anti-peptide reactivity, the existence of two immunodominat domains, namely the V3 region of the surface (SU) glycoprotein and the domain including the highly conserved sequence QNQFF of the transmembrane (TM) glycoprotein, was detected; antibody-binding sites were also mapped in the domain overlapping the cleavage site between SU and TM encompassing the V6 variable region. Moreover, at least two novel linear B epitopes, the former spanning residues 427M-H446 and the latter spanning residues 737N-N756 and likely representing a "type-specific" determinant, have been revealed. The battery of synthetic peptides was then used to immunize outbred Swiss mice in the attempt to reveal other potential sites of immunogenicity of the Env glycoproteins. Analysis of peptide-immunized mouse sera for anti-peptide reactivity revealed more numerous B cell epitopes, generally mapping in different peptides, as compared with those defined in the feline system. None of the mouse anti-peptide sera, however, proved neutralizing for FIV-Pet.
In Utero Exposure to Fine Particulate Matter Causes Hypertension Due to Impaired Renal Dopamine D1 Receptor in Offspring (2018)

In utero exposure to PM2.5 increases ROS and GRK4 expression, impairs D1R-mediated sodium excretion, and increases blood pressure in the offspring. These studies suggest that normalization of D1R function may be a target for the prevention and treatment of the hypertension in offspring of mothers exposed to PM2.5 during pregnancy.