gebhart/patrepeval huggingface dataset:
NORADRENERGIC CEREBRAL STIMULATION OF SENSORINEURAL IMPAIRED SUBJECTS (1988)

Norepinephrine has been shown to improve signal-to-noise ratios of sensory systems, including that of the auditory system. Yohimbine has been observed to cause a selective increase of cerebral norepinephrine. It was administered in one dose to sensorineurally impaired subjects with the object of improving their speech hearing in noise. Speech intelligibility was measured by the adaptive procedure. Mild, significant improvement was noted in one of the hearing components, "attenuation," and an adverse effect was shown on "distortion," owing to noise. Auditory brainstem response was improved significantly. The objective of temporarily improving intelligibility in noise was not attained.
Computer Adaptive Testing: A Strategy for Monitoring Stroke Rehabilitation Across Settings (2004)

Current functional assessment instruments in stroke rehabilitation are often setting-specific and lack precision, breadth, and/or feasibility. Computer adaptive testing (CAT) offers a promising potential solution by providing a quick, yet precise, measure of function that can be used across a broad range of patient abilities and in multiple settings. CAT technology yields a precise score by selecting very few relevant items from a large and diverse item pool based on each individual's responses. We demonstrate the potential usefulness of a CAT assessment model with a cross-sectional sample of persons with stroke from multiple rehabilitation settings.
Investigation of the Mechanism of Polar Excitations on Frog Sciatic Nerve by Optical Stimulation (2011)

We observed nerve excitations on bullfrog sciatic nerves by an optical stimulation using a Holmium YAG (Ho:YAG) laser with the laser power over 2.0 [W]. The laser power was higher the amplitude of the action potential was bigger. However, when the laser power over 10.0 [W], the laser gave damage to the sciatic nerve and the action potential decreased. Not only the action potential was evoked by the high temperature but also the sciatic nerve was damaged by an overlarge temperature. These results show the possibility that the single wavelength laser can use to position estimation of epileptogenic focus and irreversible blocking of propagation of epilepsy seizure.
Impedance spectroscopy as a technique for monitoring aging effects in nickel hydrogen and nickel-metal hydride batteries (2003)

Impedance spectroscopy is evaluated as a method for the early detection of aging effects in electrochemical cells. AC impedance and phase measurements were made on about 85 cells in various stages of life testing. Spectral data from 3 mHz to 30 kHz were acquired on fully discharged cells. Impedance spectroscopy provided an effective means of detecting age diversity present in the test population. This could be seen in the data at very low frequencies, below 1 Hz. This is the so called Warburg region where the availability of charge carriers is diffusion controlled. Both raw impedance data and Argand diagrams, in which reactance is plotted as a function of resistance, represent useful graphical outputs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comparison of lidocaine and bronchodilator inhalation treatments for cough suppression in patients with chronic obstructive pulmonary disease (2005)

Both lidocaine and bronchodilator inhalation treatments are equally effective for short term cough suppression in patients with COPD.
Azulene‐to‐Naphthalene Rearrangement: The Car–Parrinello Metadynamics Method Explores Various Reaction Mechanisms (2004)

We studied the thermal intramolecular and radical rearrangement of azulene to naphthalene by employing a novel metadynamics method based on Car-Parrinello molecular dynamics. We demonstrate that relatively short simulations can provide us with several possible reaction mechanisms for the rearrangement. We show that different choices of the collective coordinates can steer the reaction along different pathways, thus offering the possibility of choosing the most probable mechanism. We consider herein three intramolecular mechanisms and two radical pathways. We found the norcaradiene pathway to be the preferable intramolecular mechanism, whereas the spiran mechanism is the favored radical route. We obtained high activation energies for all the intramolecular pathways (81.5-98.6 kcal mol(-1)), whereas the radical routes have activation energies of 24-39 kcal mol(-1). The calculations have also resulted in elementary steps and intermediates not yet considered. A few attractive features of the metadynamics method in studying chemical reactions are pointed out.
Histone Monoubiquitylation Position Determines Specificity and Direction of Enzymatic Cross-talk with Histone (2012)

S It is well established that chromatin is a destination for signal transduction, affecting many DNA-templated processes. His- tone proteins in particular are extensively post-translationally modified. We are interested in how the complex repertoire of histone modifications is coordinately regulated to generate meaningful combinations of marks at physiologically relevant genomic locations. One important mechanism is between pre-existing histone post-translational modifications and enzymes that subsequently add or remove modifications on chromatin. Here, we use chemically defined designer nucleo- somes to investigate novel enzymatic cross-talk relationships between the most abundant histone ubiquitylation sites, H2AK119ub and H2BK120ub, and two important histone methyltransferases, Dot1L and PRC2. Although the presence of H2Bub in nucleosomes greatly stimulated Dot1L methylation of H3K79, we found that H2Aub did not influence Dot1L activity. In contrast, we show that H2Aub inhibited PRC2 methylation of H3K27, but H2Bub did not influence PRC2 activity. Taken together, these results highlight how the position of nucleosome monoubiquitylation affects the specificity and direction of cross-talk with enzymatic activities on chromatin.
Galactose Transport in Saccharomyces cerevisiae II. Characteristics of Galactose Uptake and Exchange in Galactokinaseless Cells (1970)

The characteristics of the inducible galactose system in Saccharomyces cerevisiae were studied by using the nonmetabolized galactose analogues, l-arabinose and d-fucose, and galactokinaseless and transportless mutants. Induced wild-type cells transport l-arabinose by facilitated diffusion. Transportless cells transport neither galactose nor l-arabinose above the noninduced rate, whereas galactokinaseless cells transport galactose l-arabinose and d-fucose by facilitated diffusion. Determination of unidirectional rate of (14)C-labeled galactose uptake by preloaded galactokinaseless cells, containing a large unlabeled free-galactose pool, showed that the rate of galactose uptake by facilitated diffusion is greater than the rate of galactose metabolism at similar external galactose concentrations.
Vorkommen von Weichmachern (Phthalaten) in Gemeinschaftseinrichtungen unter besonderer Bedeutung der Ergebnisse von LUPE 3 (2013)

Children are a very susceptible subgroup of the general population and therefore health authorities have a special interest to prevent them from health hazards. In a study of 3 German Bundesländer the indoor air and dust samples of altogether 63 German daycare centres were analysed for the presence of phthalate diesters in 2011/12 (LUPE 3 study). Inhalable dust and gas phases were collected with a glass fibre filter and polyurethane foam over approximately 6 h while children were attending these facilities. Settled dust was collected by vacuuming the floor of the room using an ALK dust sampler. Indoor air and dust were analysed using a GC/MS system. Median values in the dust samples were 888 mg/kg for di-2-ethylhexyl phthalate (DEHP), 302 mg/kg for diisononyl phthalate (DiNP), 34 mg/kg for diisodecyl phthalate (DiDP), 21 mg/kg for di-n-butyl phthalate (DnBP), and 20 mg/kg for diisobutyl phthalate (DiBP). For DEHP and DiNP maximum values of 10,086 mg/kg and 7,091 mg/kg were observed, respectively. DEHP and DiNP were responsible for 70% and 24% of the total phthalate concentration in the dust. In indoor air phthalates are found mainly in the particulate phase of the filters. Only the more volatile phthalates dimethyl phthalate and diethyl phthalate were found also in the gas phase. The median values in the indoor air were 470 ng/m³ for DiBP, 230 ng/m³ for DnBP, 190 ng/m³ for DEHP, and 100 ng/m³ for DiNP. DnBP and DiBP were together responsible for 55% of the total phthalate concentration in the indoor air. Overall, our study showed that the concentrations of phthalates in indoor air of daycare centers are slightly higher and in dust samples lower compared with schools.
Growth, water use efficiency, and sodium and potassium acquisition by tomato cultivars grown under salt stress (2000)

Abstract Three cultivars of tomato (Lycopersicon esculentum Mill., cvs. Sera, 898, Rohaba) were grown under different levels of NaCl in nutrient solution to determine effects of salt stress on shoot and root dry matter (DM), plant height, water use efficiency (WUE, g DM kg‐1 water evapotranspired), shoot sodium (Na) and potassium (K) concentrations, and K versus Na selectivity (SK,Na). Increasing NaCl concentration in nutrient solution adversely affected shoot and root DM, plant height, WUE, K concentration, and K/Na ratio of all cultivars. Shoot Na concentrations increased with increasing NaCl concentration in the nutrient solution. Although increasing salt concentration in the solution adversely affected growth of all cultivars, the cultivar Sera had the highest shoot and root DM than the other two cultivars (898 and Rohaba). Shoot and root DM of cultivar 898 was most affected by salt, while cultivar Rohaba had an intermediate salt sensitivity. The cultivar Sera generally had higher WUE values, shoot K concentrations, and SK,Na, but had lower shoot Na concentrations than the other two cultivars when plants were grown under different salt levels. Greater Na exclusion, higher K uptake and shoot SK,Na are suggested as being plant strategies for salt tolerance.
Evaluation of a Microfocused Ultrasound System for Improving Skin Laxity and Tightening in the Lower Face (2014)

2.
Binding of macaque serum FH to FHbp by ELISA. (2015)

&lt;p&gt;An animal with high FH binding to FHbp was heterozygous in domain 6 for Y352 with S360 (YS) and Y352 with P360 (YP) (magenta squares). For comparison, examples are shown of a high FH binding control serum from an animal heterozygous with H352 and P360 (HP) and Y352 and P360 (YP) (green circles), and a control serum with low FH binding from an animal with homozygous H352 and P360 (HP/HP) (grey triangles). The means and ranges of two to four replicates are shown.&lt;/p&gt;
Adaptive impedance control in haptic teleoperation to improve transparency under time-delay (2008)

This paper proposes the application of an adaptive impedance control scheme to alleviate some of the problems associated with the presence of time delays in a haptic teleoperation system. Continuous on-line estimation of the remote environment's impedance is performed, and is then used as a local model for haptic display control. Lyapunov stability of the proposed impedance adaptation law is demonstrated. A series of experiments is performed to evaluate the performance of this teleoperation control scheme. Two performance measures are defined to assess transparency and stability of the teleoperator. Simulation results show the superior performance of the proposed adaptive scheme, with respect to direct teleoperation, particularly in terms of increasing the stability margin and of significantly ameliorating transparency in the presence of large time delays. Experimental results, using a phantom omni as the haptic master device, support this conclusion.
Enabling PC-based HIL simulation for automotive applications (2002)

This paper describes new technologies that enable the use of the affordable PC hardware as the computing platform for high-performance electromechanical simulation. Challenging applications such as real-time hardware-in-the-loop and mega-simulation are made possible using a combination of a PC-based simulation environment, distributed architecture, and software solutions to numerical problems that arise from fixed-time step integration. The technologies are flexible enough to allow expansion and reconfiguration, and cover the entire design process from modeling to real-time simulation or control without the engineer ever having to write code.
Interstitial glucose concentration and glycemia: implications for continuous subcutaneous glucose monitoring (2000)

The changes in plasma glucose concentration and in interstitial glucose concentration, determined with a miniaturized subcutaneous glucose sensor, were investigated in anesthetized nondiabetic rats. Interstitial glucose was estimated through two different calibration procedures. First, after a glucose load, the magnitude of the increase in interstitial glucose, estimated through a one-point calibration procedure, was 70% of that in plasma glucose. We propose that this is due to the effect of endogenous insulin on peripheral glucose uptake. Second, during the spontaneous secondary decrease in plasma glucose after the glucose load, interstitial glucose decreased faster than plasma glucose, which may also be due to the effect of insulin on peripheral glucose uptake. Third, during insulin-induced hypoglycemia, the decrease in interstitial glucose was less marked than that of plasma glucose, suggesting that hypoglycemia suppressed transfer of glucose into the interstitial tissue; subsequently, interstitial glucose remained lower than plasma glucose during its return to basal value, suggesting that the stimulatory effect of insulin on peripheral glucose uptake was protracted. If these observations obtained in rats are relevant to human physiology, such discrepancies between plasma and interstitial glucose concentration may have major implications for the use of a subcutaneous glucose sensor in continuous blood glucose monitoring in diabetic patients.
Optical modulation techniques for underwater detection, ranging and imaging (2011)

The focus of this paper is to describe research being conducted at NAVAIR in Patuxent River, MD to improve optical detection, ranging and imaging in the underwater environment through the use of optical modulation techniques. The modulation provides a way to discriminate against unwanted scattered light that would otherwise reduce detection sensitivity. Another benefit of modulating the transmitted light is that coherent detection of the modulation envelope results in the ability to accurately measure the range to the underwater object. Ways to use the hardware and methods developed for the detection, ranging, and imaging scenario to satisfy other mission requirements are also being investigated. The requirements for the modulation scheme, modulation frequency, and laser characteristics (pulsed, continuous, optical power level) depend on the targeted application. The implementation of this optical modulation technique in a variety of underwater sensors has become possible due to recent advances in laser and receiver technology. A review of the work being done in this area of research will be presented, and results from laboratory experiments will be discussed.
Targeting lipid signalling in cancer (2010)

Phosphoinositide 3-kinases (PI3Ks) play an important role in a variety of cellular activities, including mitogenic signalling and cell survival, cytoskeletal remodelling, metabolic control, proliferation and vesicular trafficking. Consistent with their function in cell survival and growth, the gene for the class Iα PI3K catalytic subunit is a common site of cancer mutations. Ongoing structural studies of these enzymes and the complexes they make with their regulatory subunits have helped to clarify the mechanistic basis of this role in tumor development. The broad spectrum of biological activities associated with various isotypes of class I PI3Ks has led to an intense search for isotype-specific inhibitors as tools in mammalian cell biology and for therapeutic application.
Seroreactivity toE. coliouter membrane protein C antibodies in active inflammatory bowel disease; diagnostic value and correlation with phylogroup B2E. coliinfection (2011)

Omp C titer was not raised in patients with active IBD compared with patients in remission. In addition, there was no difference in Omp C level in patients with active Crohn's disease compared with controls. These observations do not support the use of Omp C serology testing, either in disease activity assessment, or in screening for active Crohn's disease.
Data from Infigratinib in Patients with Recurrent Gliomas and <i>FGFR</i> Alterations: A Multicenter Phase II Study (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;&lt;i&gt;FGFR&lt;/i&gt; genomic alterations (amplification, mutations, and/or fusions) occur in ∼8% of gliomas, particularly &lt;i&gt;FGFR1&lt;/i&gt; and &lt;i&gt;FGFR3&lt;/i&gt;. We conducted a multicenter open-label, single-arm, phase II study of a selective FGFR1–3 inhibitor, infigratinib (BGJ398), in patients with &lt;i&gt;FGFR&lt;/i&gt;-altered recurrent gliomas.&lt;/p&gt;Patients and Methods:&lt;p&gt;Adults with recurrent/progressive gliomas harboring &lt;i&gt;FGFR&lt;/i&gt; alterations received oral infigratinib 125 mg on days 1 to 21 of 28-day cycles. The primary endpoint was investigator-assessed 6-month progression-free survival (PFS) rate by Response Assessment in Neuro-Oncology criteria. Comprehensive genomic profiling was performed on available pretreatment archival tissue to explore additional molecular correlations with efficacy.&lt;/p&gt;Results:&lt;p&gt;Among 26 patients, the 6-month PFS rate was 16.0% [95% confidence interval (CI), 5.0–32.5], median PFS was 1.7 months (95% CI, 1.1–2.8), and objective response rate was 3.8%. However, 4 patients had durable disease control lasting longer than 1 year. Among these, 3 had tumors harboring activating point mutations at analogous positions of &lt;i&gt;FGFR1&lt;/i&gt; (K656E; &lt;i&gt;n&lt;/i&gt; = 2) or &lt;i&gt;FGFR3&lt;/i&gt; (K650E; &lt;i&gt;n&lt;/i&gt; = 1) in pretreatment tissue; an &lt;i&gt;FGFR3-TACC3&lt;/i&gt; fusion was detected in the other. Hyperphosphatemia was the most frequently reported treatment-related adverse event (all-grade, 76.9%; grade 3, 3.8%) and is a known on-target toxicity of FGFR inhibitors.&lt;/p&gt;Conclusions:&lt;p&gt;FGFR inhibitor monotherapy with infigratinib had limited efficacy in a population of patients with recurrent gliomas and different &lt;i&gt;FGFR&lt;/i&gt; genetic alterations, but durable disease control lasting more than 1 year was observed in patients with tumors harboring &lt;i&gt;FGFR1&lt;/i&gt; or &lt;i&gt;FGFR3&lt;/i&gt; point mutations or &lt;i&gt;FGFR3-TACC3&lt;/i&gt; fusions. A follow-up study with refined biomarker inclusion criteria and centralized &lt;i&gt;FGFR&lt;/i&gt; testing is warranted.&lt;/p&gt;&lt;/div&gt;
Power Generation from Waste Heat Using Heat Pipe and Thermoelectric Generator (2015)

This paper presents the investigation of power generation using the combination of heat pipes and thermo-electric generators. A majority of thermal energy in the industry is dissipated as waste heat to the environment. This waste heat can be utilized further for power generation. The related problems of global warming and dwindling fossil fuel supplies has led to improving the efficiency of any industrial process being a priority. One method to improve the efficiency is to develop methods to utilize waste heat that is usually wasted. Two promising technologies that were found to be useful for this purpose were thermoelectric generators and heat pipes. Therefore, this project involved making a bench type, proof of concept model of power production by thermoelectric generators using heat pipes and simulated hot air. The laboratory experiment of the proposed system was obtained with a counter flow air duct heat exchanger. The results obtained show an increase in the ratio of mass flow rate in upper duct to lower duct has a positive effect on the overall system performance. A higher mass flow rate ratio results in a higher amount of heat transfer and higher power output. The proposed system can be used for waste heat recovery from the industry where thermal energy is used in their daily process.
Multiphoton tomography in differentiation of morphological and molecular subtypes of breast cancer: A quantitative analysis (2021)

In this study multiphoton tomography, based on second harmonic generation (SHG), and two-photon-excited fluorescence (TPEF) was used to visualize both the extracellular matrix and tumor cells in different morphological and molecular subtypes of human breast cancer. It was shown, that quantified assessment of the SHG based imaging data has great potential to reveal differences of collagen quantity, organization and uniformity in both low- and highly- aggressive invasive breast cancers. The values of quantity and uniformity of the collagen fibers distribution were significantly higher in low-aggressive breast cancer compared to the highly-aggressive subtypes, while the value representing collagen organization was lower in the former type. Additionally, it was shown, that TPEF detection of elastin fibers and amyloid protein may be used as a biomarker of detection the low-aggressive breast cancer subtype. Thus, TPEF/SHG imaging offers the possibility of becoming a useful tool for the rapid diagnosis of various subtypes of breast cancer during biopsy as well as for the intraoperative determinination of tumor-positive resection margins.
Fabrication of highly efficient organic electroluminescent devices (1998)

Efficient organic electroluminescent (EL) devices were fabricated by using a highly fluorescent aluminum complex, tris(4-methyl-8-quinolinolato)aluminum(III) (Almq3), as an emitter layer. In addition to using this complex, a multilayer device structure, consisting of a hole-injecting layer, a hole transport layer, a dye-doped Almq3 emitting layer, and an electron transport layer, was employed in order to reduce the driving voltage as well as to maximize carrier recombination efficiency. From this device, a maximum luminance of over 140 000 cd/m2 and an external quantum efficiency of 7.1% was observed, which is the highest efficiency ever reported for organic EL devices.
Fast modeling of shared caches in multicore systems (2011)

This work presents StatCC, a simple and efficient model for estimating the shared cache miss ratios of co-scheduled applications on architectures with a hierarchy of private and shared caches. StatCC leverages the StatStack cache model to estimate the co-scheduled applications' cache miss ratios from their individual memory reuse distance distributions, and a simple performance model that estimates their CPIs based on the shared cache miss ratios. These methods are combined into a system of equations that explicitly models the CPIs in terms of the shared miss ratios and can be solved to determine both. The result is a fast algorithm with a 2% error across the SPEC CPU2006 benchmark suite compared to a simulated in-order processor and a hierarchy of private and shared caches.
Acquisition system for biomedical data (1977)

Multifunctional biomedical data-acquisition system monitors cardiovascular and pulmonary performance of patient in real time.