gebhart/patrepeval huggingface dataset:
The West Africa ICEMR Partnerships for Guiding Policy to Improve the Malaria Prevention and Control (2022)

The Mali National Malaria Control Program (NMCP) recently established a phased set of goals for eliminating malaria in Mali by 2030. Over the past decade, the scale-up of NMCP-led malaria control interventions has led to considerable progress, as evidenced by multiple malariometric indicators. The West Africa International Center of Excellence in Malaria Research (WA-ICEMR) is a multidisciplinary research program that works closely with the NMCP and its partners to address critical research needs for malaria control. This coordinated effort includes assessing the effectiveness of control interventions based on key malaria research topics, including immune status, parasite genetic diversity, insecticide and drug resistance, diagnostic accuracy, malaria vector populations and biting behaviors, and vectorial capacity. Several signature accomplishments of the WA-ICEMR include identifying changing malaria age demographic profiles, testing innovative approaches to improve control strategies, and providing regular reporting on drug and insecticide resistance status. The NMCP and WA-ICEMR partnership between the WA-ICEMR and the NMCP offers a comprehensive research platform that informs the design and implementation of malaria prevention and control research programs. These efforts build local expertise and capacity for the next generation of malaria researchers and guide local policy, which is crucial in sustaining efforts toward eliminating malaria in West Africa.
Thermal decomposition of a sulfoximide in the presence of a carboxylic acid; an interesting rearrangement (1979)

Abstract 5‐Hexyl‐7‐( S ‐methylsulfonimidoyl)xanthone‐2‐carboxylic acid 1a , when heated above its melting point gives a number of products including the corresponding methyl ester 1b , which arises by a novel methyl group transfer. A similar methyl transfer reaction is observed when the sulfoximide and carboxylic acid groups are present in different molecules.
Source Data for "Harnessing hematopoietic stem cell low intracellular calcium improves their maintenance in vitro" (2019)

The source data for ~70 panels of data used to compute statistical significance in the paper.
Transparency Effect in Zr−B−N Coatings Obtained by Magnetron Sputtering of ZrB2 Target (2020)

Thin fims in the Zr−B−N system possessing optical transparency have been studied. It is established that increase in the volume fraction of nitrogen in the gas mixture and, hence, in the concentration of nitrogen in the coatings leads to an increase in their optical transmission due to the formation of a BN phase.
Atividade inseticida de óleos essenciais e fixos sobre Callosobruchus maculatus (FABR., 1775) (Coleoptera: Bruchidae) em grãos de caupi [Vigna unguiculata (L.) WALP.] (2008)

O caruncho, Callosobruchus maculatus (Fabr.), é considerado a praga mais importante do caupi, Vigna unguiculata (L.) Walp., armazenado em regiões tropicais e subtropicais. Visando minimizar os efeitos indesejáveis dos inseticidas químicos sintéticos, o controle dessa praga com óleos de origem vegetal vem se constituindo numa alternativa promissora, de baixo custo e segura para os aplicadores e consumidores. Foram testados os óleos essenciais [(Cymbopogon martini (Roxb.) J.F. Watson], Piper aduncum L., Piper hispidinervum C.DC., Melaleuca sp., Lippia gracillis Shauer) e fixos (Helianthus annuus L, Sesamum indicum L, Gossypium hirsutum L., Glycine max (L.) Merr. e Caryocar brasiliense Camb.), em grãos de caupi, cv. Sempre Verde. Os óleos foram utilizados nas concentrações 10, 20, 30, 40 e 50mL/20g, correspondendo a 0,5, 1,0, 1,5, 2,0 e 2,5 L/t e impregnados aos grãos no interior de recipientes de plástico, com auxílio de pipetador automático e agitados manualmente durante dois minutos. Parcelas de 20g de caupi foram infestadas com oito fêmeas de C. maculatus, com 0 a 48 h de idade. Cada óleo foi testado, separadamente, em delineamento inteiramente casualisado com seis repetições. Os óleos essenciais de C. martini, P. aduncum e L. gracillis causaram 100% de mortalidade em todas as concentrações, P. hispidinervum a partir de 1,5 L/t e Melaleuca sp. nas concentrações de 2,0 e 2,5 L/t. A redução do número de ovos viáveis e de insetos emergidos foi de 100% para todos os óleos essenciais, exceto Melaleuca sp. Por outro lado, os óleos fixos, apesar de apresentarem baixa mortalidade em todas as concentrações testadas, reduziram em praticamente 100% o número de ovos viáveis e de insetos emergidos.
Intravenous Fluid Bolus Therapy: A Bi-national Survey of Critical Care Nurses' Self-Reported Practice (2016)

Knowledge of critical care nurses' intravenous fluid bolus therapy (FBT) practice remains underexplored. Using a multi-choice online survey conducted between September and October 2014, we sought to describe the self-reported practice of critical care nurses located in Australia and New Zealand. Two hundred and ninety-five critical care nurses responded to the survey with most practising in adult ICUs. Overall, 0.9% saline solution was the preferred solution for FBT. However, more Australian than New Zealand respondents preferred 'albumin 4%' (31% versus 3.6%, P <0.01) for FBT. In contrast, more New Zealand respondents preferred 'Plasma-Lyte®' (33.3% versus 6.4%, P <0.01). Half of the respondents defined FBT as 250 ml administered as quickly as possible. However, FBT volumes ranged from 100 ml to >1000 ml and administration duration from as quickly as possible to 60 minutes. In response to FBT, almost half of the respondents expected an increase in mean arterial pressure of between 11 to 20 mmHg. Similarly, >40% expected a central venous pressure increase >3 mmHg, >70% expected a urinary output increase of 0.5 to 1.0 ml/kg/hr, and >60% expected a decrease in heart rate of >11 /min. Overall, 0.9% saline remains the most common solution for FBT, but there are significant national differences in the preference for albumin and Plasma-Lyte. A volume of 250 ml defines a fluid bolus, with a range from 100 ml to >1000 ml, and speed of delivery from stat to 60 minutes. Most nurses expect substantial physiological effects with FBT.
Inside Cover: Synthesis of a Single‐Crystalline Macroporous Layered Silicate from a Macroporous UTL‐Type Zeolite and Its Accelerated Intercalation (Chem. Eur. J. 46/2017) (2017)

A single-crystalline macroporous layered silicate was obtained through hydrothermal synthesis of UTL-type zeolite with macropores under the presence of acetylene black, subsequent calcination for removal of the template, and selective leaching of double four membered ring units in the UTL framework. Intercalation of tetrabutylammonium ions into the macroporous layered silicate is accelerated if compared with that into the same silicate without macropores, indicating the effectiveness of macropores due to easy diffusion. More information can be found in Full Paper by K. Kuroda et al. on page 11022.
A Novel Technique for the Expression and Purification of HIV-1 VIF Co-factor APOBEC3G (2004)

HIV-1 has evolved to protect itself against the body's innate viral defense mechanisms. One such example of this phenomenon is illustrated by the viral protein vif, which is expressed in the later stages of infection. Vif binds the host cell protein Apobec3G, a cytidine deaminase which is ectopically expressed in non-permissive cell lines to allow for reverse transcription of the HIV-1 viral genome. Apobec3G has the ability to prevent HIV-1 replication by mutating the cDNA, so the goal of this research was to develop a novel technique for the expression and purification of Apobec3G. An expression and purification technique was developed, and the purified Apobec3G protein was shown to have the capacity for binding viral Vif in vitro.
Original article Chronic intussusception in childhood (1998)

A rare case of chronic intussusception is re- ported. Radiological investigation including ultra- sound, CT and barium enema provided the correct di- agnosis. Ultrasound revealed a solid mass near the transverse colon in the right lower abdomen. CT demonstrated the real nature of the solid mass as be- ing the classical coiled spring' of intussusception. The barium enema was unsuccessful as an attempt at hydrostatic reduction, but confirmed the diagnosis by a crescent-shaped' filling defect in the ascending colon. The patient was discharged after an uneventful surgery and recovery. No organic lesion that precipi- tated the chronic intussusception was discovered at operation. Radiological findings, the typical clinical picture and adequate treatment are discussed.
The Disproportionation of Aromatic Stiboso Compounds. II. Methods of Synthesis (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Disproportionation of Aromatic Stiboso Compounds. II. Methods of SynthesisG. O. Doak and H. H. JafféCite this: J. Am. Chem. Soc. 1950, 72, 7, 3025–3027Publication Date (Print):July 1, 1950Publication History Published online1 May 2002Published inissue 1 July 1950https://doi.org/10.1021/ja01163a062Request reuse permissionsArticle Views99Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (377 KB) Get e-Alertsclose Get e-Alerts
Isolation of Bacillus amyloliquefaciens JK6 and identification of its lipopeptides surfactin for suppressing tomato bacterial wilt (2015)

A rhizobacteria strain, <italic>B</italic>. <italic>amyloliquefaciens</italic> JK6, isolated from the rhizosphere soil of healthy tomato plants, significantly inhibited <italic>Ralstonia solanacearum</italic> (RS).
TDMA is Optimal for All-Unicast DoF Region of TIM if and only if Topology is Chordal Bipartite (2018)

The main result of this paper is that an orthogonal access scheme, such as time division multiple access achieves the all-unicast degrees of freedom (DoF) region of the topological interference management problem if and only if the network topology graph is chordal bipartite, i.e., every cycle that can contain a chord, does contain a chord. The all-unicast DoF region includes the DoF region for any arbitrary choice of a unicast message set, so e.g., the results of Maleki and Jafar on the optimality of orthogonal access for the sum-DoF of one-dimensional convex networks are recovered as a special case. The result is also established for the corresponding topological representation of the index coding problem.
Investigation and optimization of parameters affecting the multiply charged ion yield in AP-MALDI MS (2016)

Liquid matrix-assisted laser desorption/ionization (MALDI) allows the generation of predominantly multiply charged ions in atmospheric pressure (AP) MALDI ion sources for mass spectrometry (MS) analysis. The charge state distribution of the generated ions and the efficiency of the ion source in generating such ions crucially depend on the desolvation regime of the MALDI plume after desorption in the AP-to-vacuum inlet. Both high temperature and a flow regime with increased residence time of the desorbed plume in the desolvation region promote the generation of multiply charged ions. Without such measures the application of an electric ion extraction field significantly increases the ion signal intensity of singly charged species while the detection of multiply charged species is less dependent on the extraction field. In general, optimization of high temperature application facilitates the predominant formation and detection of multiply charged compared to singly charged ion species. In this study an experimental set-up and optimization strategy is described for liquid AP-MALDI MS which improves the ionization efficiency of selected ion species up to 14 times. In combination with ion mobility separation, the method allows the detection of multiply charged peptide and protein ions for analyte solution concentrations as low as 2fmol/μL (0.5μL, i.e. 1fmol, deposited on the target) with very low sample consumption in the low nL-range.
Development of Crystallographic Texture and In‐Grain Misorientation in CVD‐Produced Single and Polycrystalline Diamond (2011)

Abstract Extensive bulk and micro‐texture measurements are used to characterize single and polycrystalline diamond thin films of different film thicknesses produced using CVD. With increasing film thickness, texturing improves and in‐grain misorientation drops. This is observed for both single and polycrystalline films. Improved texturing in polycrystalline diamond can be rationalized from growth selection/advantage, however explanation(s) on the in‐grain misorientation development and its relationship with texturing, if any, remain pending.
The long term evolution towards a new 3GPP* air interface standard (2007)

The performance targets for the long term evolution (LTE) of the Universal Mobile Telecommunication System (UMTS) into a 4th generation system have been chosen to be very ambitious. While all of these targets may not be achievable in practice, they have served to motivate the decisions for a particular LTE design. Specifically, we discuss the choice of the multiple access scheme for LTE, provide details on the uplink and downlink transmission formats, analyze the benefits of multiple input multiple output (MIMO), and outline approaches for intercell interference mitigation. The trade-off between usage of MIMO spatial multiplexing and beamforming is shown for a practical system. The required signaling overhead is weighed against the performance improvements available from the additional information. Finally, some examples for the achievable physical layer performance are given. © 2007 Alcatel-Lucent.
Removal of a Volatile Organic Compound in a Hybrid Rotating Drum Biofilter (2004)

A hybrid bioreactor, combining an activated sludge process (ASP) and a rotating drum biofilter (RDB), was developed and evaluated for the treatment of volatile organic compounds (VOCs) in waste gas streams. The effects of the influent VOC concentration and the organic loading rate on the VOC removal efficiency and on the pattern of biomass accumulation were investigated. Toluene was used as the model VOC, the flow rate of the waste gas stream was 0.59 L/s, and the empty-bed retention time (EBRT) in the ASP portion was 46 s with an actual retention time of about 2 s. The EBRT in the RDB portion was 38 s based on the drum volume. When the VOC feed concentration increased from 221 to 884 mg toluene/m3 (from 57.2 to 229 ppm), correspondingly the organic loading rate of the hybrid bioreactor increased from 1.58 to 6.32 kg chemical oxygen demand/m3/day (from 0.505 to 2.02kg toluene/m3/day) based on the drum volume, both the ASP and RDB decreased, and the overall toluene removal efficiency declined from 99.8 to 74.1%. Biomass accumulation at different medium depths became more even when the organic loading rate was increased. Part of the applied VOC was biodegraded by the ASP, which suggests that this hybrid bioreactor could achieve longer runs between medium cleanings and higher VOC removal efficiencies than a single RDB bioreactor without an ASP portion at the same organic loading rate.
A Mini Review of Biodegradable Calcium Phosphate Nanoparticles for Gene Delivery (2014)

Nucleic acid drugs are promising new therapeutics for the treatment of various diseases including genetic diseases, viral diseases, and cancer. However, their poor intracellular bioavailability and rapid degradation hinder their development as drugs. Therefore, the main challenge is to develop an efficient delivery system. Calcium phosphate has been widely used to transfect cultured cells for 40 years, due to its safety, simply of production and noticeable efficacy of transfection. Unfortunately, calcium phosphate particles show poor colloidal stability because of uncontrolled growth, which impedes their practical use. Recently, investigators have designed a variety of biodegradable calcium phosphate nanocarriers and achieved efficient gene delivery both in vitro and in vivo with low toxicity. In this review, we focus on the current research activity in the development of calcium phosphate nanoparticlss for gene delivery. Calcium phosphate nanoparticles are mainly classified into lipid coated and polymer coated ones for discussion. In addition, cellular uptake and intracellular trafficking of calcium phosphate nanoparticles are also mentioned.
Emerging drugs for Guillain-Barré syndrome (2011)

GBS is a heterogeneous disease with considerable short- and long-term disability for which more effective and individualized treatments are required. Under investigation are new treatment strategies with adapted IVIg dosages based on prognostic factors and more specific immunomodulation, including complement inhibitors.
Epicardial adipose excision slows the progression of porcine coronary atherosclerosis (2014)

In pigs used as their own controls, resection of cEAT decreased the progression of CAD, suggesting that cEAT may exacerbate coronary atherosclerosis.
An antigen processing polymorphism revealed by HLA‐B8‐restricted cytotoxic T lymphocytes which does not correlate with TAP gene polymorphism (1993)

In previous studies of antigen presentation through HLA-B27, we identified a healthy person whose lymphoblastoid cells do not present three B27-restricted viral epitopes to specific cytotoxic T lymphocytes (CTL), despite adequate cell surface expression of HLA-B2702 of normal sequence. Similar findings were observed in all members of his family sharing the HLA-A3-B2702 haplotype. The original donor, NW, carries HLA-B8 on his other class I haplotype, which his daughter, HW, has inherited. We now report a failure to present an HLA-B8-restricted epitope from influenza nucleoprotein following viral infection of NW cells, although exogenous added peptide is still presented normally. However, cells from HW, which do not carry the A3-B2702 haplotype, present the expected epitope after viral infection. Another B8-restricted epitope, from human immunodeficiency virus-gag, is presented equally well by both cell lines when infected with gag-vaccinia. This antigen processing phenotype does not correlate with any of the known human TAP-1 and TAP-2 polymorphisms.
Revisiting the Birth of 7YSZ Thermal Barrier Coatings: Stephan Stecura † (2018)

Thermal barrier coatings are widely used in all turbine engines, typically using a 7 wt.% Y2O3–ZrO2 formulation. Extensive research and development over many decades have refined the processing and structure of these coatings for increased durability and reliability. New compositions demonstrate some unique advantages and are gaining in application. However, the “7YSZ” (7 wt.% yttria stabilized zirconia) formulation predominates and is still in widespread use. This special composition has been universally found to produce nanoscale precipitates of metastable t’ tetragonal phase, giving rise to a unique toughening mechanism via ferro-elastic switching under stress. This note recalls the original study that identified superior properties of 6–8 wt.% yttria stabilized zirconia (YSZ) plasma sprayed thermal barrier coatings, published in 1978. The impact of this discovery, arguably, continues in some form to this day. At one point, 7YSZ thermal barrier coatings were used in every new aircraft and ground power turbine engine produced worldwide. 7YSZ is a tribute to its inventor, Dr. Stephan Stecura, NASA retiree.
Characterization of human RNA splice signals by iterative functional selection of splice sites (2000)

An iterative in vitro splicing strategy was employed to select for optimal 3' splicing signals from a pool of pre-mRNAs containing randomized regions. Selection of functional branchpoint sequences in HeLa cell nuclear extract yielded a sequence motif that evolved from UAA after one round of splicing toward a UACUAAC consensus after seven rounds. A significant part of the selected sequences contained a conserved AAUAAAG motif that proved to be functional both as a polyadenylation signal and a branch site in a competitive manner. Characterization of the branchpoint in these clones to either the upstream or downstream adenosines of the AAUAAAG sequence revealed that the branching process proceeded efficiently but quite promiscuously. Surprisingly, the conserved guanosine, adjacent to the common AAUAAA polyadenylation motif, was found to be required only for polyadenylation. In an independent experiment, sequences surrounding an optimal branchpoint sequence were selected from two randomized 20-nt regions. The clones selected after six rounds of splicing revealed an extended polypyrimidine tract with a high frequency of UCCU motifs and a highly conserved YAG sequence in the extreme 3' end of the randomized insert. Mutating the 3' terminal guanosine of the intron strongly affects complex A formation, implying that the invariant AG is recognized early in spliceosome assembly.
Network Structure Identification From Corrupt Data Streams (2020)

Complex networked systems can be modeled as graphs with nodes representing the agents and links describing the dynamic coupling between them. Previous work on network identification has shown that the network structure of linear time-invariant (LTI) systems can be reconstructed from the joint power spectrum of the data streams. These results assumed that data are perfectly measured. However, real-world data are subject to many corruptions, such as inaccurate time-stamps, noise, and data loss. We show that identifying the structure of linear time-invariant (LTI) systems using corrupt measurements results in the inference of erroneous links. We provide an exact characterization and prove that such erroneous links are restricted to the neighborhood of the perturbed node. We extend the analysis of LTI systems to the case of Markov random fields with corrupt measurements. We show that data corruption in Markov random fields results in spurious probabilistic relationships in precisely the locations, where spurious links arise in LTI systems.
Measurement of integrated flux of cosmic ray muons at sea level using the INO-ICAL prototype detector (2012)

The India-based Neutrino Observatory (INO) collaboration is planning to set-up a magnetized Iron-CALorimeter (ICAL) to study atmospheric neutrino oscillations with precise measurements of oscillations parameters. The ICAL uses 50 kton iron as target mass and about 28800 Resistive Plate Chambers (RPC) of 2 m × 2 m in area as active detector elements. As part of its R&D program, a prototype detector stack comprising 12 layers of RPCs of 1 m × 1 m in area has been set-up at Tata Institute of Fundamental Research (TIFR) to study the detector parameters using cosmic ray muons. We present here a study of muon flux measurement at sea level and lower latitude. (Site latitude: 18°54'N, longitude: 72°48'E.)