gebhart/patrepeval huggingface dataset:
Using a Digital Marketing Platform for the Promotion of an Internet Based Health Encyclopedia in Saudi Arabia (2015)

The objective of this paper is to investigate the experiences of using a digital marketing platform to promote the use of an internet based health encyclopedia in Saudi Arabia. Key informant interviews, meeting documentation, and Google Analytics were the data collection sources used in the study. Findings show that using a digital marketing platform led to a significant increase in the number of visitors to the health encyclopedia. The results demonstrate that digital marketing platforms are effective tools to be used for promoting internet based health education interventions. Future work will examine long-term educational impacts and costs in using digital marketing platforms to promote online healthcare sites in Saudi Arabia.
Why are women still leaving academic medicine? A qualitative study within a London Medical School (2022)

The women in our focus group reported several factors contributing to their decision to leave clinical academia, which included lack of mentoring tailored to specific needs, low levels of acceptance for flexible working to help meet parental responsibilities and perceived explicit gender biases. We summarise the multiple targeted strategies that Imperial College London has implemented to promote retention of women in academic medicine, although more research needs to be done to ascertain the most effective interventions.
Evolution of analog networks using local string alignment on highly reorganizable genomes (2004)

We introduce and apply a genetic representation for analog electronic circuits based on the association of character strings extracted from the genome with the terminals and parameters of components, and the use of local string alignment to generate the connection between components. The representation produces a variable genome length structure that tolerates the execution of major genome reorganization operators such as duplication and transposition, along with less disruptive ones such as character insertion, deletion and substitution. The representation can be applied also to other analog networks such as artificial neural networks, control systems, and genetic regulatory networks.
A Clinicopathological Study of Lung Cancer Patients with Occupational Exposure to Chrysotile Asbestos Fibers. (1999)

Occupational asbestos exposure is interpreted as one of the important risks for lung cancer and frequent and accurate observation is necessary.
Laser cladding with powder, effect of some machining parameters on clad properties (1998)

ardness, bonding and microstructure. Hence, it was decided to introduce this technique in the Dutch industry. The project consisted of three parts. One part covered the achievement and enhancement of insight in phenomena that occur in laser cladding. The second part involved the development of tools that facilitate the use of laser cladding. The third part consisted of the development of practical applications. Some aspects of this project are discussed in this thesis. This thesis is directed to laser cladding with powder and a CO 2 laser as heat source. The laser beam intensity profile turned out to be an important pa- 6 Summary rameter in laser cladding. A numerical model was developed that allows the prediction of the surface temperature distribution that is attained with an arbitrarily shaped intensity profile. Input parameters for this model are laser machining parameters and properties of the laser beam, as well as material properties and the absorption of laser energy at the s
ChemInform Abstract: Structure of Synthetic Copper Sodium Monophosphate. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Global Data Association for SLAM with 3D Grassmannian Manifold Objects (2022)

Using pole and plane objects in lidar SLAM can increase accuracy and decrease map storage requirements compared to commonly-used point cloud maps. However, place recognition and geometric verification using these landmarks is challenging due to the requirement for global matching without an initial guess. Existing works typically only leverage either pole or plane landmarks, limiting application to a restricted set of environments. We present a global data association method for loop closure in lidar scans using 3D line and plane objects simultaneously and in a unified manner. The main novelty of this paper is in the representation of line and plane objects extracted from Iidar scans on the manifold of affine subspaces, known as the affine Grassmannian. Line and plane correspondences are matched using our graph-based data association framework and subsequently registered in the least-squares sense. Compared to pole-only approaches and plane-only approaches, our 3D affine Grassmannian method yields a 71 % and 325 % increase respectively to loop closure recall at 100 % precision on the KITTI dataset and can provide frame alignment with less than 10 cm and 1 deg of error.
The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1 (2021)

Actin is a hallmark protein of the cytoskeleton in eukaryotic cells, affecting a range of cellular functions. Actin dynamics is regulated through a myriad of actin-binding proteins and post-translational modifications. The mammalian actin family consists of six different isoforms, which vary slightly in their N-terminal (Nt) sequences. During and after synthesis, actins undergo an intricate Nt-processing that yields mature actin isoforms. The ubiquitously expressed cytoplasmic β-actin is Nt-acetylated by N-alpha acetyltransferase 80 (NAA80) yielding the Nt-sequence Ac-DDDI-. In addition, β-actin was also reported to be Nt-arginylated by arginyltransferase 1 (ATE1) after further peptidase-mediated processing, yielding RDDI-. To characterize in detail the Nt-processing of actin, we used state-of-the-art proteomics. To estimate the relative cellular levels of Nt-modified proteoforms of actin, we employed NAA80-lacking cells, in which actin was not Nt-acetylated. We found that targeted proteomics is superior to a commercially available antibody previously used to analyze Nt-arginylation of β-actin. Significantly, despite the use of sensitive mass spectrometry-based techniques, we could not confirm the existence of the previously claimed Nt-arginylated β-actin (RDDI-) in either wildtype or NAA80-lacking cells. A very minor level of Nt-arginylation of the initially cleaved β-actin (DDDI-) could be identified, but only in NAA80-lacking cells, not in wildtype cells. We also identified small fractions of cleaved and unmodified β-actin (DDI-) as well as cleaved and Nt-acetylated β-actin (Ac-DDI-). In sum, we show that the multi-step Nt-maturation of β-actin is terminated by NAA80, which Nt-acetylates the exposed Nt-Asp residues, in the virtual absence of previously claimed Nt-arginylation.
Importance of control engineering to minimize torsional vibration in variable speed drive systems (2016)

Applications incorporating Variable Speed Drives (VSD) may experience torsional vibration problems. The vibration phenomenon can typically appear from two reasons: Excitation of torsional resonance by pulsating torque ripple and closed loop electro-mechanical interaction between VSD and driven load. This paper aims to explain the mechanism of torsional vibration in VSD and proposes an approach to model complete drive system in order to predict the torsional vibration and optimize the control system prior to commissioning. The method is easy to apply and much less time consuming compared to time domain simulations. The theoretical results are verified on a real example of 6'100 kW compressor drive.
Efficient multitarget particle filters for ground target tracking (2005)

Many factors make the ground target tracking problem decidedly nonlinear and non-Gaussian. Because these factors can lead to a multimodal posterior density, a Bayesian filtering solution is appropriate. In the last decade, the particle filter has emerged as a Bayesian inference technique that is both powerful and simple to implement. In this work, we demonstrate the necessity of using multiple-target particle filters when two or more tracks are linked through measurement contention. We also develop an efficient way to implement these filters by adaptively managing the type of particle filters, the number of particles, and the enumeration of hypotheses during data association. Using simulated data, we compare the run-time of our adaptive particle filter algorithm to the run-times of two baseline particle filters, to demonstrate that our design mitigates the increase in computation required when performing joint multitarget tracking.
The BB-rat-an authentic model of human diabetic retinopathy (1985)

The pathogenesis of diabetic retinopathy has not been fully explained. The earliest histological lesion is the loss of intramural pericytes and thickening of the basement membrane. Increased activity of the polyol pathway is a probable mechanism for these two abnormalities. Investigations have suffered from the lack of an exact animal model simulating the human condition. Examination of the retina in the spontaneously diabetic BB-rat demonstrated degeneration and loss of intramural pericytes, a progressive increase in basement membrane thickness, and microinfarctions with areas of non-perfusion. Therefore, this model may be used to clarify the biochemical mechanism(s) linking the metabolic abnormalities of diabetes and the retinopathy.
The structure and dynamic behaviour of disubstituted derivatives of [Rh6(CO)16] containing heterobidentate bridging phosphine ligands (2003)

The solution structures and dynamic behaviour of [Rh6(CO)14(μ-PX)] [PX = diphenyl(2-pyridyl)phosphine, (PN); diphenyl(2-thienyl)phosphine, (PS); diphenyl(vinyl)phosphine, (PV)] have been studied by multinuclear NMR and the X-ray structure of [Rh6(CO)14(μ,κ3-PV)] is reported. In solution, the above clusters undergo a variety of localised CO-exchanges and the mechanisms of these are discussed. The PV ligand in [Rh6(CO)14(μ,κ3-PV)] is hemilabile and exhibits facile exchange/reorientation of the vinyl group.
Insect immunity. Isolation of cDNA clones corresponding to diptericin, an inducible antibacterial peptide from Phormia terranovae (Diptera) (1989)

We have previously isolated and characterized a family of novel 8-kDa cationic antibacterial peptides synthesized by larvae of Phormia terranovae (Diptera) in response to various injuries. These molecules have been named diptericins. The peptide sequence of diptericin A was used to prepare oligonucleotides for screening cDNA libraries and we report in the present paper the isolation of several cDNA clones encoding diptericin. The analysis of the nucleotide sequences indicates that diptericin is synthesized as a prepeptide which is matured in two steps: (a) cleavage of a signal peptide and (b) amidation of the C-terminal residue. Interestingly, the 3' untranslated region of the mRNA contains a consensus sequence TTATTTAT which is also observed in the mRNA of another insect antibacterial peptide (attacin-related sarcotoxin IIA) and in mRNAs encoding proteins related to the inflammatory response in mammals. Our data illustrate that diptericins form a polymorphic family of immune peptides. The transcription of the diptericin genes is rapidly induced in the fat body after inoculation of bacteria, as evidenced by the transcriptional profile.
Coagulation and growth mechanisms for dust particles in a low-temperature plasma (2004)

We suggest a theoretical model of dust clustering in a low-temperature plasma that includes a description of all the main stages of this process, from the initial growth and coagulation of particles to the saturation phase. Based on the constructed theory, we have explained the experimentally observed threshold behavior of the coagulation process for the first time and estimated the critical microparticle size upon reaching which transition from the growth of particles through the deposition of material from the gas phase to their coagulation becomes possible. Using the derived analytical expressions for the coagulation rate constant, we numerically simulated the clustering process based on data taken for real experimental conditions and studied the evolution of the particle size distribution function during the entire process. A direct comparison of the numerical calculations with experimental data shows them to be in good agreement with the actually observed pattern of the phenomenon.
High-frequency flyback transformer linked utility-connected sinewave soft-switching power conditioner using a switched capacitor snubber (2004)

In this paper, the high-frequency switching pulse modulation utility-interfaced power conditioner with a flyback high-frequency transformer link has been proposed. With the aid of the switched-capacitor resonant snubber cell, the high-frequency switching devices in the primary side of the proposed DC-to-AC power inverter can be turned-off with zero voltage soft-switching (ZVS). Moreover, the proposed power conditioner operates the currents in the discontinuous conduction mode (DCM) and takes the advantages of zero current soft switching turn-on. Its output port is connected directly to the utility grid AC power source. At the end, the prototype of the proposed HF-UPC is built and tested in the experiments. Its power conversion processing is verified and the output current is qualified in accordance with the guidelines of the power systems.
Enhanced Perception Shared by Automotive Safety Applications Supporting Active Intervention - The Interactive System Overview (2011)

The interactIVe project addresses the development and evaluation of next-generation safety systems for Intelligent Vehicles, based on sensor fusion, situation awareness algorithms, and active intervention. Safety technologies have shown outstanding capabilities for supporting the driver in hazardous situations. Despite their effectiveness, currently available systems are typically implemented as independent functions. This results in multiple expensive sensors and unnecessary redundancy, limiting their scope to premium-class vehicles. The interactIVe system architecture is based on the concept that by integrating applications together, vehicle components may be shared among the various safety systems. Considering the proposed system architecture, the focus of the present technical paper is on specifications of the system discrete layers in order to define a unified system able to perform active intervention by taking into account both longitudinal and lateral support and by using generic interfaces applicable to different demonstrator vehicles.
CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14,15-Epoxyeicosatrienoic Acid (EET) (2011)

CYP3A4 expression in breast cancer correlates with decreased overall survival, but the mechanisms are unknown. Cytochrome P450 gene profiling by RNAi silencing demonstrates that CYP3A or 2C8 gene expression is specifically required for growth of the breast cancer lines MCF7, T47D, and MDA-MB-231. CYP3A4 silencing blocks the cell cycle at the G(2)/M checkpoint and induces apoptosis in the MCF7 line, thereby inhibiting anchorage-dependent growth and survival. CYP3A4 was profiled for NADPH-dependent arachidonic acid (AA) metabolism and synthesized AA epoxygenase products (±)-8,9-, (±)-11,12-, and (±)-14,15-epoxyeicosatrienoic acid (EET) (total turnover of ∼2 pmol/pmol CYP3A4/min) but not hydroxylase products (±)-15-, (±)-19-, or 20-hydroxyeicosatetraenoic acid. Furthermore, eicosanoid profiling revealed that MCF7 cells synthesize EETs in a CYP3A4-dependent manner. The (±)-14,15-EET regioisomer selectively rescues breast cancer cells from CYP3A4 silencing in a concentration-dependent fashion and promotes mitogenesis and anchorage-dependent cloning. Stat3 (Tyr-705) phosphorylation was inhibited by CYP3A4 silencing, providing a potential mechanism for CYP3A4 involvement in breast cancer cell growth. Silencing Stat3 blocks breast cancer cell growth and abrogates (±)-14,15-EET-induced proliferation, indicating a Stat3 requirement for (±)-14,15-EET-mediated cell growth. Although silencing of CYP3A4 reduces nuclear Tyr(P)-705-Stat3, (±)-14,15-EET restores this signaling process and promotes Tyr(P)-705-Stat3 translocation to the nucleus, suggesting that (±)-14,15-EET may be involved in an autocrine/paracrine pathway driving cell growth. These studies indicate that CYP3A4 is a highly active AA epoxygenase that promotes Stat3-mediated breast cancer cell growth in part through (±)-14,15-EET biosynthesis. Furthermore, these studies indicate an essential role for Stat3 as a mediator of epoxygenase activity in breast cancer.
Echinococcus granulosus strain differentiation in Iran based on sequence heterogeneity in the mitochondrial 12S rRNA gene (2008)

Parasite strain characterization is essential for the establishment of a prevention and control strategy in any endemic area. The aim of this study was to characterize different Echinococcus granulosus isolates from Iran by using DNA sequences of the mitochondrial 12S rRNA gene. Thirty livers and lungs of cattle, sheep and goats naturally infected with E. granulosus were collected from abattoirs in northern and western Iran between June and October 2007. These samples yielded 18 fertile cysts which we used for the genetic work. We designed and tested two new primer pairs which specifically amplify portions of the mitochondrial 12S rRNA gene of the two strains (G1 and G6) of E. granulosus known to occur in Iran. One primer pair amplified a fragment of 259 base pairs (bp) from only the G1 strain. The second pair amplified a fragment of 676 bp from the G6 strain. The G1 genotype was identified in all fertile cyst samples, in agreement with previous studies in Iran. Ten of our samples and a single reference sample of the G6 strain were sequenced and compared with the G1 and G6 sequences deposited in GenBank.
Growth of Rubella Virus in BHK21 Cells. III. Production of Complement-Fixing Antigens. (1967)

SummaryThe production of rubella CF antigen was studied in a cloned line of BHK21 cells cultured in monolayer or in suspension. Two antigens were demonstrated: one present in purified virus preparation and associated with the virus particle, and the second soluble and tending to appear late in the course of infection of BHK21 tissue culture.
Cough and Angioneurotic Edema Associated with Angiotensin-Converting Enzyme Inhibitor Therapy (1992)

Cough occurs in 5% to 20% of patients treated with ACE inhibitors, recurring with reintroduction of the same or another ACE inhibitor. It is more common in women. The mechanism may involve accumulation of prostaglandins, kinins (such as bradykinin), or substance P (neurotransmitter present in respiratory tract C-fibers); both bradykinin and substance P are degraded by ACE. A 4-day trial of withdrawal of the ACE inhibitor or temporary substitution of another class of antihypertensive agent inexpensively and easily ascertains if the ACE inhibitor caused the cough. Change to another ACE inhibitor or additive therapy with nonsteroidal anti-inflammatory drugs is not recommended. Prompt recognition of ACE inhibitor-related cough can prevent unnecessary diagnostic testing and treatment. Angioedema occurs in 0.1% to 0.2% of patients receiving ACE inhibitors. The onset usually occurs within hours or, at most, 1 week after starting therapy. The mechanism may involve autoantibodies, bradykinin, or complement-system components. Treatment involves first protecting the airway, followed by epinephrine, antihistamines, and corticosteroids if needed. Therapy is then resumed with an alternate class of antihypertensive agent.
Expression of Drosophila melanogaster gene encoding transcription factor GAGA is tissue‐specific and temperature‐dependent (1997)

The GAGA factor (GAF) of Drosophila melanogaster encoded by the Trithorax-like gene is known to maintain expression of many Drosophila genes including homeotic ones, through configuration remodeling of local chromatin. The complicated transcript pattern of the GAF gene has been revealed at all stages of development. The study of GAF gene expression in whole flies and in salivary glands and in the brains with adjacent imaginal disks of the third instar larvae showed tissue-specific variations in transcript patterns and dependence of these patterns on the temperature of development (14-37 degrees C).
Elaboration by mammalian mesenchymal cells infected with Trypanosoma cruzi of a fibroblast-stimulating factor that may contribute to chagasic cardiomyopathy (1987)

Myocardial fibrosis can occur as a complication of chronic infection of the heart with Trypanosoma cruzi (Chagas' disease) and can lead to serious disability. To assess whether there might be a direct relationship between intracellular parasitization and subsequent tissue fibrosis in this disease, we tested serum-free conditioned media from cultures of fibroblasts, vascular smooth-muscle cells, and myocardial cells for fibroblast-stimulating activity. Conditioned media from all infected cultures, but not from uninfected cultures, stimulated fibroblast [3H]thymidine incorporation, DNA and protein synthesis, and cell proliferation. Fibroblast-stimulating activity was also detected in extracts of amastigotes but not of trypomastigotes or epimastigotes. We conclude that parasitization of mesenchymal cells, including myocardial cells, results in elaboration of a fibroblast-stimulating factor(s), perhaps of parasite origin. We postulate that this factor may play a role in initiation of myocardial fibrosis in Chagas' disease.
Gene Therapy for Bladder Overactivity and Nociception with Herpes Simplex Virus Vectors Expressing Preproenkephalin (2009)

Interstitial cystitis/painful bladder syndrome (IC/PBS) is a major challenge to treat. We studied the effect of targeted and localized expression of enkephalin in afferent nerves that innervate the bladder by gene transfer using replication-defective herpes simplex virus (HSV) vectors in a rat model of bladder hyperactivity and pain. Replication-deficient HSV vectors encoding preproenkephalin, which is a precursor for Met- and Leu-enkephalin, or control vector encoding the lacZ reporter gene, were injected into the bladder wall of female rats. After viral vector injection, quantitative polymerase chain reaction showed high preproenkephalin transgene levels in bladder and dorsal root ganglia innervating the bladder in enkephalin vector-treated animals. Functionally, enkephalin vector-treated animals showed reductions in bladder hyperactivity and nociceptive behavior induced by intravesical application of capsaicin; however, vector-mediated expression of enkephalin did not alter normal voiding. This antinociceptive effect of enkephalin gene therapy was antagonized by naloxone hydrochloride administration. Together, our results with HSV vectors encoding preproenkephalin demonstrated physiological improvement in visceral pain induced by bladder irritation. Thus, gene therapy may represent a potentially useful treatment modality for bladder hypersensitive disorders such as IC/PBS.