gebhart/patrepeval huggingface dataset:
Mechanical Property of TaC Particulate Reinforced Al Alloy Composites with High Volume Fraction and Its Model Calculation (1996)

TaCp/Al alloy composites were fabricated by the melt stirring method. The composites can be fabricated up to 40 vol% reinforcement and can be cast up to 30 vol%. Very few reaction products between TaCp and the matrix alloy can be detected by scanning electron microscopy. The tensile strength, 0.2% proof stress and Young’s modulus of TaCp/pure Al composites increase and the uniform elongation decreases with increasing volume fraction. The strength of TaCp/Al-3 mass%Mg composites increases up to 20 vol% reinforcement but decreases with more than 20 vol% because they have some pores. The theoretical calculation based on the Eshelby’s inclusion model can explain the feature of strain hardening of experimental stress-strain curves, but the calculated stress values are much lower than the experimental ones. To improve the theoretical prediction of stress-strain curves of composites, the calculation model was modified by taking into account the effects of the residual stress caused by mismatch in coefficients of thermal expansion (CTE) and the change of matrix properties caused by grain refining into the yield stress of matrix alloy in composites. The modified calculation can fairly explain the experimental stress-strain curves, though these effects on the matrix yield stress are different with respect to the particle volume fraction. The predicted stress values are higher than the experimental ones in the composites with small volume fractions and are lower in the composites with high volume fractions.
EMI-Series-Electromagnetic Fuel Injection Pumps (1988)

&lt;div class="htmlview paragraph"&gt;Usage of solenoid valves capable of controlling fuel delivery to several engine cylinders in succession reduces the cost and complexity of electromagnetic fuel injection systems. A new type of injection pump employing solenoid valves with shuttles is described. In a multiplunger pump such a solenoid valve controls operation of two plungers in succession. The number of required solenoids is equal to half the number of engine cylinders. A review and analysis of the basic concept is given, and test results are discussed.&lt;/div&gt;
Generic Dynamic Model for Simulation and Control of Reactive Extrusion (2004)

A one-dimensional physically motivated dynamic model of a twin-screw extruder for reactive extrusion has been developed. This model predicts the transient and stationary behavior of the extruder for pressure, filling ratio, temperature, and molar conversion profiles as well as residence time distribution under various operating conditions. The model consists of a cascade of perfectly stirred reactors that can be either fully filled with backflow or partially filled according to the operating conditions. Each reactor is described by the reactant concentrations and the melt temperature. A piece of barrel and screw, described by their temperature, is associated with each reactor. Living polymerization of ε-caprolactone with tetrapropoxytitanium as the initiator is chosen as an example of application. The flow representation aspect of the model is validated by using experimental residence time distributions. Validation of the model is derived from simulation results as well as comparison with experimental data.
Outcomes of Anterior Distal Femoral Hemiepiphysiodesis in Children with Musculoskeletal Disorders (2019)

Purpose: Anterior distal femoral hemiepiphysiodesis (ADFH) is often performed to correct fixed knee flexion deformities in children with neuromuscular conditions. Previous studies have demonstrated the effectiveness of ADFH to improve knee range of motion; however, literature comparing the effectiveness of 8-plates versus transphyseal screws is limited. There is no information in the literature about effectiveness of 1- versus 2- transphyseal screw constructs. The purpose of our study was …
Reduction of Renal Superoxide Dismutase in Progressive Diabetic Nephropathy (2009)

Superoxide excess plays a central role in tissue damage that results from diabetes, but the mechanisms of superoxide overproduction in diabetic nephropathy (DN) are incompletely understood. In the present study, we investigated the enzyme superoxide dismutase (SOD), a major defender against superoxide, in the kidneys during the development of murine DN. We assessed SOD activity and the expression of SOD isoforms in the kidneys of two diabetic mouse models (C57BL/6-Akita and KK/Ta-Akita) that exhibit comparable levels of hyperglycemia but different susceptibility to DN. We observed down-regulation of cytosolic CuZn-SOD (SOD1) and extracellular CuZn-SOD (SOD3), but not mitochondrial Mn-SOD (SOD2), in the kidney of KK/Ta-Akita mice which exhibit progressive DN. In contrast, we did not detect a change in renal SOD expression in DN-resistant C57BL/6-Akita mice. Consistent with these findings, there was a significant reduction in total SOD activity in the kidney of KK/Ta-Akita mice compared with C57BL/6-Akita mice. Finally, treatment of KK/Ta-Akita mice with a SOD mimetic, tempol, ameliorated the nephropathic changes in KK/Ta-Akita mice without altering the level of hyperglycemia. Collectively, these results indicate that down-regulation of renal SOD1 and SOD3 may play a key role in the pathogenesis of DN.
Tumor Necrosis Factor Receptor 2 Contributes to Ozone-induced Airway Hyperresponsiveness in Mice (2001)

whole body plethysmography; polymorphonuclear leukocytes; minute ventilation; knockout mice; methacholine
Improved directed loop method for Quantum Monte Carlo simulations (2003)

Efficient schemes called directed loops for cluster updates in Quantum Monte Carlo simulations have recently been proposed, which improve both the efficiency and precision for simulations of quantum models. In this work we show that local detailed balance is not necessary in order to fulfill global detailed balance during the construction of these loops. We therefore propose to insert additional degrees of freedom into the directed loop equations, resulting in even more efficient algorithms. Our approach works directly in the natural representation of an extended space where the matrix elements of the operators defining the worm (broken worldline segments) are taken into account.
Thermal ablative treatment of uterine fibroids (2015)

In addition to surgical methods of treating uterine fibroids, numerous non-invasive treatments have been developed. Many of these involve the use of hyperthermia, the heating of tissue by a variety of methods. These include the use of lasers, radiofrequency, microwave energy and high intensity focused ultrasound, guided by both ultrasound and magnetic resonance imaging. In this review we examine the technology behind these treatment modalities and review the current evidence for their use.
Multicore Enablement for Embedded and Cyber Physical Systems (Dagstuhl Seminar 13052) (2013)

This report documents the program and the outcomes of Dagstuhl Seminar 13052 "Multicore Enablement for Embedded and Cyber Physical Systems. During the seminar the participants from industry and academia actively discussed chances and problems of multicore processors in embedded in cyber-physical systems. The focus of the seminar was on the exchange of experiences and discussion of the challenges of reusable and transferable multicore technologies. Those were covered in the individual talks and plenum discussions. Beside that, working groups have been formed to discuss and present important topics in detail, which are also part of this report.
Site specific immobilization of a potent antimicrobial peptide onto silicone catheters: evaluation against urinary tract infection pathogens (2014)

Bacterial colonization of urinary catheters is a common problem leading to Catheter Associated Urinary Tract Infections (CAUTIs) in patients, which result in high treatment costs and associated complications. Due to the advantages of antimicrobial peptides (AMPs) compared to most other antimicrobial molecules, an increasing number of AMP-coated surfaces is being developed but their efficacy is hindered by suboptimal coating methods and loss of peptide activity upon surface tethering. This study aims to address this issue by employing a methodic approach that combines a simple selective chemical immobilization platform developed on a silicone catheter with the choice of a potent AMP, Lasioglossin-III (Lasio-III), to allow site specific immobilization of Lasio-III at an effective surface concentration. The Lasio-III peptide was chemically modified at the N-terminal with a cysteine residue to facilitate cysteine-directed immobilization of the peptide onto a commercial silicone catheter surface via a combination of an allyl glycidyl ether (AGE) brush and polyethylene glycol (PEG) based chemical coupling. The amount of immobilized peptide was determined to be 6.59 ± 0.89 μg cm<sup>-2</sup> by Sulfo-SDTB assay. The AMP-coated catheter showed good antimicrobial activity against both Gram positive and negative bacteria. The antimicrobial properties of the AMP-coated catheter were sustained for at least 4 days post-incubation in a physiologically relevant environment and artificial urine and prevented the biofilm growth of E. coli and E. faecalis. Adenosine tri-phosphate leakage and propidium iodide fluorescence studies further confirmed the membranolytic mode of action of the immobilized peptide. To the best of our knowledge, this is the first proof-of-concept study that reports the efficacy of AMP immobilization by sulfhydryl coupling on a real catheter surface.
Innovative construction techniques and functional verification on airfield pavements—a Dutch case study (2017)

There is a push for improving the on-site pavement construction process. In addition, agencies change their specifications towards functional requirements and increase their guarantee periods. However, there is a gap between the tests in the laboratory design phase (CE-marking) and the properties achieved in the field. Also, the on-site construction process is traditionally not routinely monitored. This makes it hard to relate field properties to properties used in the design and properties declared on the CE-marking. This research addresses this gap as well as the need for a better understanding of the on-site construction processes. In the Dutch airfield construction project Rotterdam The Hague Airport, mechanical properties (indirect tensile cracking resistance and triaxial permanent deformation resistance) were determined on (a) laboratory-mixed, laboratory-compacted specimens, (b) plant-mixed, laboratory-compacted specimens, and (c) plant-mixed, field-compacted specimens. Using this methodology, functional verification became possible and it allowed directly comparing field properties with properties promised in the pavement design and declared on the CE-mark. Additionally, supporting technologies were successfully introduced, such as GPS, laserlinescanners and infrared cameras, to monitor the asphalt temperature variability and the number of roller passes. The results made the on-site process explicit and show a consistent and homogeneous process. The paper demonstrates that the fracture energy of the CE-marking specimens are a pretty good estimator for the final fracture energy achieved in the field. Further, the paper demonstrates how technologies can be used to monitor the on-site construction process. Together, this contributes to a deeper understanding of the construction process, consistent asphalt quality and functionally verified field properties.
Regional Enteritis Associated with Enterovirus in a Patient with X-Linked Agammaglobulinemia (2000)

To the Editor: Gryfe et al. (Jan. 13 issue) 1 report that microsatellite instability in colorectal cancer is independently predictive of a favorable outcome. We have some concern about this conclusion, since the tumors with microsatellite instability were more frequently localized (59 percent, vs. 38 percent of those with microsatellite stability) and since the 10-year survival at each Dukes' stage did not differ significantly between patients with microsatellite instability and those with microsatellite stability (Fig. The authors state that in a multivariate analysis, microsatellite status was found to be "significantly and independently" associated with survival. In our opinion, however, we still need clear evidence in a univariate analysis of a survival advantage at each Dukes' stage.
Improving Quality of Experience by Adding Device Resource Reservation to Service Discovery Protocols (2008)

Current service discovery protocols (SDP) hardly provide information on the actual availability of resources in the network or a mechanism for (device) resource reservation. When the resources cannot serve all multiple client requests at the same time, conflicts happen, often involving heavy and frequent reconfiguration traffic. This paper presents a generic resource reservation scheme. Its properties are derived from common SDP operations. We built a prototype, measured the extra overhead such a reservation manager introduces and simulated the gain in network scalability. The main conclusion is that our solution improves the scalability and the sustainability of the service access significantly, and at a minor cost.
Characterization of the Fetal Blood Transcriptome and Proteome in Maternal Anti‐Fetal Rejection: Evidence of a Distinct and Novel Type of Human Fetal Systemic Inflammatory Response (2013)

We describe a systemic inflammatory response in human fetuses born to mothers with evidence of maternal anti-fetal rejection. The transcriptome and proteome of this novel type of fetal inflammatory response were different from that of FIRS type I (which is associated with acute infection/inflammation).
Arabidopsis SDG8 Potentiates the Sustainable Transcriptional Induction of the Pathogenesis-Related Genes PR1 and PR2 During Plant Defense Response (2020)

Post-translational covalent modifications of histones play important roles in modulating chromatin structure and are involved in the control of multiple developmental processes in plants. Here we provide insight into the contribution of the histone lysine methyltransferase SET DOMAIN GROUP 8 (SDG8), implicated in histone H3 lysine 36 trimethylation (H3K36me3), in connection with RNA polymerase II (RNAPII) to enhance <i>Arabidopsis</i> immunity. We showed that even if the <i>sdg8-1</i> loss-of-function mutant, defective in H3K36 methylation, displayed a higher sensitivity to different strains of the bacterial pathogen <i>Pseudomonas syringae</i>, effector-triggered immunity (ETI) still operated, but less efficiently than in the wild-type (WT) plants. In <i>sdg8-1</i>, the level of the plant defense hormone salicylic acid (SA) was abnormally high under resting conditions and was accumulated similarly to WT at the early stage of pathogen infection but quickly dropped down at later stages. Concomitantly, the transcription of several defense-related genes along the SA signaling pathway was inefficiently induced in the mutant. Remarkably, albeit the defense genes <i>PATHOGENESIS-RELATED1</i> (<i>PR1</i>) and <i>PR2</i> have retained responsiveness to exogenous SA, their inductions fade more rapidly in <i>sdg8-1</i> than in WT. At chromatin, while global levels of histone methylations were found to be stable, local increases of H3K4 and H3K36 methylations as well as RNAPII loading were observed at some defense genes following SA-treatments in WT. In <i>sdg8-1</i>, the H3K36me3 increase was largely attenuated and also the increases of H3K4me3 and RNAPII were frequently compromised. Lastly, we demonstrated that SDG8 could physically interact with the RNAPII C-terminal Domain, providing a possible link between RNAPII loading and H3K36me3 deposition. Collectively, our results indicate that SDG8, through its histone methyltransferase activity and its physical coupling with RNAPII, participates in the strong transcriptional induction of some defense-related genes, in particular <i>PR1</i> and <i>PR2</i>, to potentiate sustainable immunity during plant defense response to bacterial pathogen.
CNN based Sinogram Denoising for Low-Dose CT (2018)

Reduction of source flux results in an increase of noise in data sinograms, which subsequently produces artifacts in the corresponded reconstructed images. We use deep-learning to denoise the original sinograms, resulting in higher quality images.
Relative Potency of Cellular and Humoral Immune Responses Induced by DNA Vaccination (2000)

DNA vaccines can prime broad-based immune responses in small animal models. In the present study, we sought to evaluate the relative ability of DNA vaccines to induce humoral and cellular immune responses. Using a DNA vaccine encoding HIV gag in mice, we observed that CD8+ T cell responses were primed more readily than were antibody responses, particularly at low doses of DNA. These CD8+ T cell responses were detected in spleen cells, as well as at local sites such as the lung and draining lymph nodes. The potency of the HIV gag DNA vaccine used was sufficient to prime strong CTL responses in macaques, but only low to undetectable antibody responses. Therefore, DNA vaccines appear able to prime strong, broad CTL but only modest antibody responses. These results may have implications on the development of vaccines against infectious diseases where both CTL and antibody responses are desired, such as HIV.
Kinetic and thermodynamic effects in the thermal electrocyclic ring-openings of 3-fluorocyclobutene, 3,3-difluorocyclobutene, and 3-(trifluoromethyl)cyclobutene (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic and thermodynamic effects in the thermal electrocyclic ring-openings of 3-fluorocyclobutene, 3,3-difluorocyclobutene, and 3-(trifluoromethyl)cyclobuteneWilliam R. Dolbier Jr., Thomas A. Gray, Jeffrey J. Keaffaber, Lech Celewicz, and Henryk KoroniakCite this: J. Am. Chem. Soc. 1990, 112, 1, 363–367Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ja00157a055https://doi.org/10.1021/ja00157a055research-articleACS PublicationsRequest reuse permissionsArticle Views766Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design and Implementation of Wireless Trusted Access Protocol for Embedded Trusted Endpoints (2008)

Trusted computing technology provides powerful support for the solution to security issues of embedded endpoints in mobile computing environment. When an endpoint connects to the network, the predefined security policy should be checked. Only the one that meets the security policy will be allowed to access to the network. Meanwhile, the one that does not meet the security policy will be isolated. Therefore all the insecure endpoints will be refused to access the network automatically until they satisfy the policy. A lot of wireless network security issues can be solved effectively by making use of trusted endpoints and trusted access technology. In this paper, a solution to construct the hardware and software of embedded trusted endpoints is proposed, and a trusted access mechanism based on the 802.1X and trusted network connection (TNC) technology defined by Trusted Computing Group is discussed, and the design and implementation of a trusted access protocol is given. Both the trusted access mechanism and the trusted access protocol can be used in wireless networks.
Enhanced emission from Si-based light-emitting diodes using surface plasmons (2006)

Excitation of surface plasmons on metallic nanoparticles has potential for increasing the absorption and emission from thin Si devices. We report an eight-fold enhancement in electroluminescence from silicon-on-insulator light-emitting diodes at 900nm via excitation of surface plasmon resonance in silver nanoparticles, along with a redshift in the electroluminescence by 70nm by overcoating the nanoparticles with ZnS. The enhancement is due to coupling between the electromagnetic excitations of the silver nanoparticles and the waveguide modes.
Potent and Highly Selective Inhibitors of the Protein Tyrosine Phosphatase 1B (1999)

Several protein tyrosine phosphatases (PTPases) have been implicated as regulatory agents in the insulin-stimulated signal transduction pathway, including PTP1B, PTPalpha, and LAR. Furthermore, since all three enzymes are suggested to serve as negative regulators of insulin signaling, one or more may play a pivotal role in the pathogenesis of insulin resistance. We report herein the acquisition of highly selective PTP1B-targeted inhibitors. We recently demonstrated that PTP1B contains two proximal aromatic phosphate binding sites [Puius, Y. A., Zhao, Y., Sullivan, M., Lawrence, D. S., Almo S. C., and Zhang, Z. Y. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 13420-5], and we have now employed this structural feature to design and synthesize an array of bis(aryldifluorophosphonates). Not only do the lead compounds serve as potent inhibitors of PTP1B but, in addition, several exhibit selectivities for PTP1B versus PTPalpha, LAR, and VHR that are greater than 2 orders in magnitude.
Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19 (2020)

Abstract An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organs. We have reviewed previously published studies on SARS and recent studies on SARS-CoV-2 infection, named coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO), confirming that many other organs besides the lungs are vulnerable to the virus. ACE2 catalyzes angiotensin II conversion to angiotensin-(1–7), and the ACE2/angiotensin-(1–7)/MAS axis counteracts the negative effects of the renin-angiotensin system (RAS), which plays important roles in maintaining the physiological and pathophysiological balance of the body. In addition to the direct viral effects and inflammatory and immune factors associated with COVID-19 pathogenesis, ACE2 downregulation and the imbalance between the RAS and ACE2/angiotensin-(1–7)/MAS after infection may also contribute to multiple organ injury in COVID-19. The SARS-CoV-2 spike glycoprotein, which binds to ACE2, is a potential target for developing specific drugs, antibodies, and vaccines. Restoring the balance between the RAS and ACE2/angiotensin-(1–7)/MAS may help attenuate organ injuries. Graphical abstract SARS-CoV-2 enters lung cells via the ACE2 receptor. The cell-free and macrophage-phagocytosed virus can spread to other organs and infect ACE2-expressing cells at local sites, causing multi-organ injury.