gebhart/patrepeval huggingface dataset:
Polymorphisms in Candidate Genes for Blood Pressure Regulation in Young Men with Normal or Elevated Screening Blood Pressure (2001)

We have previously shown correlations between cardiovascular risk factors such as blood pressure (BP), sympathetic nervous system activity, lipids and insulin resistance in young men with elevated screening BP. In the present study we aimed to: (1) compare the genotype distribution and allele frequencies of 11 polymorphisms in seven candidate genes for BP regulation in healthy 21-year-old Caucasian men, between 18 men with normal and 67 men with high screening BP, and (2) evaluate the effect of these polymorphisms in candidate genes on casual BP, BP responses to mental stress or catecholamines and metabolic parameters including insulin sensitivity. There were no differences in genotype distributions or allele frequencies between the subjects with normal and those with high screening BP. Insulin sensitivity was significantly higher in GG homozygotes in the G-261A polymorphism at the alpha 2A-adrenergic receptor (alpha(2A)AR) locus compared to GA heterozygotes (p = 0.007). Subjects who were homozygous both GG in the G-261A polymorphism at the alpha(2A)AR locus and GlyGly in the Arg16Gly polymorphism at the beta2-adrenergic (beta2AR) receptor loci had significantly higher insulin sensitivity and lower catecholamine levels during mental stress than subjects with other genotypes. Subjects who were II homozygous at the angiotensin converting enzyme (ACE) locus and AA homozygous at the angiotensin type I receptor (AT1R) locus had lower BP and a better lipid profile than the rest of the group. Thus, in this explorative study, we report an association between insulin sensitivity and a polymorphism at the alpha(2A)AR locus. We suggest the presence of gene-gene interactions in the renin-angiotensin system and the sympathetic nervous system.
Coherency Based Spatio-Temporal Saliency Detection for Video Object Segmentation (2014)

Extracting moving and salient objects from videos is important for many applications like surveillance and video retargeting. In this paper we use spatial and temporal coherency information to segment salient objects in videos. While many methods use motion information from videos, they do not exploit coherency information which has the potential to give more accurate saliency maps. Spatial coherency maps identify regions belonging to regular objects, while temporal coherency maps identify regions with high coherent motion. The two coherency maps are combined to obtain the final spatio-temporal map identifying salient regions. Experimental results on public datasets show that our method outperforms two competing methods in segmenting moving objects from videos.
Imagining the unseen (2014)

Missing data due to occlusion is a key challenge in 3D acquisition, particularly in cluttered man-made scenes. Such partial information about the scenes limits our ability to analyze and understand them. In this work we abstract such environments as collections of cuboids and hallucinate geometry in the occluded regions by globally analyzing the physical stability of the resultant arrangements of the cuboids. Our algorithm extrapolates the cuboids into the un-seen regions to infer both their corresponding geometric attributes (e.g., size, orientation) and how the cuboids topologically interact with each other (e.g., touch or fixed). The resultant arrangement provides an abstraction for the underlying structure of the scene that can then be used for a range of common geometry processing tasks. We evaluate our algorithm on a large number of test scenes with varying complexity, validate the results on existing benchmark datasets, and demonstrate the use of the recovered cuboid-based structures towards object retrieval, scene completion, etc.
A superferromagnetic approach for rapidly quenched Y60Fe30Al10alloys (2000)

10.1088/0953-8984/12/18/310
A New Synthetic Approach for the Synthesis of N2-Modified Guanosines (2005)

A new universal route for generating N2-modified guanosines is developed and the synthesis of two examples is shown.
A Study of Forest Landscape Image Structure from Experience and Conceptualized Images (2002)

個人の過去の体験・環境・知識といった背景は, 概念化された既成イメージを作り上げ, この既成イメージが新たな環境における知覚とイメージ形成に影響を与えていると考えられる。実験参加者の概念化された森林イメージを, その描画より3つに分類し, アンケート結果より得られた個人背景と組み合わせることでグループごとの特徴を捉えた。その後, 実際に森林を散策した際のイメージ形成構造を, 写真撮影と描画により抽出したところ,(1) 都市の自然に囲まれてきたグループは, 少ない対象を個別に知覚し,(2) 幼少期に森林に親しんだグループは, 多くの対象を結び付けて対象場として知覚し,(3) 最近でも自然に親しんでいるグループは, 主体と結び付けた視点場として知覚していることが明らかになった。
SAR, Cardiac Myocytes Protection Activity and 3D-QSAR Studies of Salubrinal and its Potent Derivatives (2012)

Salubrinal is a selective inhibitor of endoplasmic reticulum (ER) stress and affords remarkable protection to cardiomyocytes. By studying the structure–activity relationship (SAR) of salubrinal, it was found that modification of the quinoline ring terminus and thiourea unit could confer the compound PP1-24 with markedly enhanced cardioprotective activity (EC50 ≤ 0.3 μM) that is 50-fold more potent than salubrinal. Comparative molecular field analysis (CoMFA) was performed using the obtained biological data and resulted in a statistically significant CoMFA model with high predictive power (q2 = 0.741, r2 = 0.991). Keywords: Cardiomyocytes protection, UPR, endoplasmic reticulum (ER) stress, eukaryotic translation initiation factor 2 subunit α (eIF2α) phosphorylation, PP1/GADD34 complex inhibitor, salubrinal, structure–activity relationships (SAR), MTT, CoMFA model, predicted abilities.
High-Pressure Hydrofullerites (2020)

This paper is a brief summary of the results of long-term experimental studies of C60Hx hydrofullerites with a hydrogen content of up to x ~ 60 or more, obtained by loading C60 fullerites with hydrogen at pressures up to 9 GPa and temperatures up to 500°C. Basically, this is an overview of already published data. Some results for hydrofullerites with compositions of x ~ 60 and x ~ 90 are presented for the first time.
Protein resistant oligo(ethylene glycol) terminated self-assembled monolayers of thiols on gold by vapor deposition in vacuum (2010)

Protein resistant oligo(ethylene glycol) (OEG) terminated self-assembled monolayers (SAMs) of thiols on gold are commonly used for suppression of nonspecific protein adsorption in biology and biotechnology. The standard preparation for these SAMs is the solution method (SM) that involves immersion of the gold surface in an OEG solution. Here the authors present the preparation of 11-(mercaptoundecyl)-triethylene glycol [HS(CH(2))(11)(OCH(2)CH(2))(3)OH] SAMs on gold surface by vapor deposition (VD) in vacuum. They compare the properties of SAMs prepared by VD and SM using x-ray photoelectron spectroscopy (XPS), polarization modulation infrared reflection absorption spectroscopy, and surface plasmon resonance measurements. VD and SM SAMs exhibit similar packing density and show a similar resistance to the nonspecific adsorption of various proteins (bovine serum albumin, trypsin, and myoglobin) under physiological conditions. A very high sensitivity of the OEG SAMs to x-ray radiation is found, which allows tuning their protein resistance. These results show a new path to in situ engineering, analysis, and patterning of protein resistant OEG SAMs by high vacuum and ultrahigh vacuum techniques.
BioCreative V BioC track overview: collaborative biocurator assistant task for BioGRID (2016)

BioC is a simple XML format for text, annotations and relations, and was developed to achieve interoperability for biomedical text processing. Following the success of BioC in BioCreative IV, the BioCreative V BioC track addressed a collaborative task to build an assistant system for BioGRID curation. In this paper, we describe the framework of the collaborative BioC task and discuss our findings based on the user survey. This track consisted of eight subtasks including gene/protein/organism named entity recognition, protein-protein/genetic interaction passage identification and annotation visualization. Using BioC as their data-sharing and communication medium, nine teams, world-wide, participated and contributed either new methods or improvements of existing tools to address different subtasks of the BioC track. Results from different teams were shared in BioC and made available to other teams as they addressed different subtasks of the track. In the end, all submitted runs were merged using a machine learning classifier to produce an optimized output. The biocurator assistant system was evaluated by four BioGRID curators in terms of practical usability. The curators' feedback was overall positive and highlighted the user-friendly design and the convenient gene/protein curation tool based on text mining.Database URL: http://www.biocreative.org/tasks/biocreative-v/track-1-bioc/.
Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage (2004)

Toxicity from radiation therapy is a grave problem for cancer patients. We hypothesized that some cases of toxicity are associated with abnormal transcriptional responses to radiation. We used microarrays to measure responses to ionizing and UV radiation in lymphoblastoid cells derived from 14 patients with acute radiation toxicity. The analysis used heterogeneity-associated transformation of the data to account for a clinical outcome arising from more than one underlying cause. To compute the risk of toxicity for each patient, we applied nearest shrunken centroids, a method that identifies and cross-validates predictive genes. Transcriptional responses in 24 genes predicted radiation toxicity in 9 of 14 patients with no false positives among 43 controls (P = 2.2 x 10(-7)). The responses of these nine patients displayed significant heterogeneity. Of the five patients with toxicity and normal responses, two were treated with protocols that proved to be highly toxic. These results may enable physicians to predict toxicity and tailor treatment for individual patients.
The Wiley encyclopedia of packaging technology (1997)

The Encyclopedia of Packaging Technology addresses a technical audience of engineers, technologists, and scientists who need an introduction to unfamiliar aspects of the packaging process. The encyclopedia will be a valuable reference for packaging engineers, but also for polymer chemists developing packaging materials and food technologists developing new products. This single-volume work contains alphabetically-arranged articles written by experts in academia or in industry. Each major article contains cross-references to related subjects within the encyclopedia, as well as a bibliography of supplemental references sources, reviewed by other experts in the field to insure completeness and objectivity.
Risk factors for cardiovascular disease do not fully explain differences in carotid intima–media thickness between Indigenous and European Australians without diabetes (2008)

After adjusting for selected risk factors, CIMT in remote Indigenous participants was still higher than in Europeans. The slope of the association between age and CIMT steepened from urban Europeans to remote Indigenous.
Fluorescence in situ hybridization: Method of choice for a definitive diagnosis of mantle cell lymphoma† (2003)

Fluorescence in situ hybridization (FISH) using IGH/CCND1 probes was used to analyze 35 specimens including 27 paraffin sections, 3 bone marrow aspirates, and 5 peripheral blood smears. The 27 paraffin sections included 7 bone marrows, 10 lymph nodes, 3 spleens, 3 tonsils, 3 gastrointestinal biopsies, and 1 skin biopsy. Among these cases, 23 specimens were from 20 patients with mantle cell lymphoma (MCL) and 12 specimens were from 12 patients with non-MCL lymphomas/lymphoid hyperplasia. Specimens from all MCL patients showed positive results with FISH. In one patient, the archived paraffin sections were negative with FISH, but a fresh peripheral blood specimen showed a positive result. Negative results were obtained in all specimens from non-MCL cases. Flow cytometric analysis revealed that all cases of MCL showed CD19/CD5 staining, but the percentages of cells positive for CD23 and FMC-7 were variable, thus they cannot be depended upon for a definitive diagnosis of MCL. Immunohistochemical stains demonstrated positive staining for CD5 and CD20 and negative staining for CD23 in MCL cases but cyclin D1 was positive in only 10 of 13 MCL cases studied. Therefore, it appears that immunophenotyping alone is not sufficient to establish a definitive diagnosis of MCL. FISH should be routinely used when the diagnosis needs confirmation. FISH can be performed in a routine clinical laboratory, and it is applicable to archived material for retrospective studies. Other molecular cytogenetic techniques in comparison with FISH are discussed.
The Distribution and Concentration of Thyrotropin-Releasimg Hormone in Discrete Human Hypothalamic Nuclei* (1979)

TRH has been measured by RIA in 8 discrete human hypothalamic nuclei, the mammillary complex, the median eminence, and infundibular stalk. Tissues were derived from 13 subjects during autopsy after sudden death. Serial micropunch brain samples were secured from 300-μm frozen sections with stainless steel cannulae 1000 or 2000 μm in diameter. Pooled samples were extracted with 0.1 N HC1, lyophilized, and resuspended in phosphate-saline buffer for TRH determinations. Stability of TRH in postmortem tissues was assessed in rats sacrificed at varying time intervals before tissue extraction. TRH was detected in all structures examined. Highest concentrations of TRH were found in the median eminence area (3.139 ng/mg protein) and arcuate nucleus (2.034 ng/mg protein). Intermediate TRH concentrations, representing 5–10% of total TRH activity, were localized to the paraventricular and periventricular nuclei. Lowest TRH concentrations were found in the mamillary complex and the posterior, supraoptic, and anterior hypothalamic nuclei. TRH activity in two rat central nervous system structures, the hypothalamus and cerebral cortex, appeared to be completely stable up to 16 h postmortem at 4 C. It is concluded that TRH is localized in part in those human hypothalamic nuclei corresponding precisely to areas implicated in TSH regulation in experimental animals. The presence of TRH in additional human hypothalamic sites also, however, suggests that TRH may be subserving other functions as well in the role of neurotransmitter or neuromodulator.
Late relapse in patients with diffuse large B‐cell lymphoma: impact of rituximab on their incidence and outcome (2019)

Diffuse large B-cell lymphoma (DLBCL) constitutes 25-35% of all non-Hodgkin lymphomas in Western countries. Approximately two thirds of the patients can be cured with standard immuno-chemotherapy. Most relapses occur within 1-2 years from diagnosis, however, the occurrence of relapses after 5 years or more has been described. We aimed at defining the incidence and clinical features of late relapses. Data of 1113 DLBCL patients were analysed. Among the 196 patients relapsing after a first complete remission, 36 (18% of relapses and 3% of all DLBCLs) experienced a recurrence more than 5 years from diagnosis. Late relapsing patients, in comparison with those relapsing earlier, showed a more favourable risk profile at presentation: normal lactate dehydrogenase levels (P = 0·002), early Ann Arbor stage (P = 0·006) and low International Prognostic Index (P = 0·003). The risk of late relapse was lowered by the introduction of rituximab as part of the front-line treatment (P < 0·001). Cause-specific survival (CSS) from the time of relapse was significantly better for late relapsing patients compared to those relapsing early: 5-year CSS rates were 53% and 31%, respectively (P = 0·033). A trend toward a better overall survival was also observed, with 5-year rates after relapse of 47% and 25%, respectively (P = 0·054).
Magnet Environments for Professional Nursing Practice (2008)

The magnet concept defines a framework for facilitating the professional practice of nursing that has demonstrated effectiveness in attracting nurses and shows promise for contributing to optimal patient outcomes. There is a compelling need to improve the measures and methods used to research magnet characteristics and environments before the links that connect organizational context to nurse and patient outcomes can be sufficiently understood.
Hypereosinophilic sclerosing cholangitis: findings using half-Fourier magnetic resonance imaging. (2000)

Hypereosinophilic sclerosing cholangitis is a rare disease caused by eosinophilic infiltration of the gallbladder and biliary tract seen in the idiopathic hypereosinophilic syndrome. We report a 42-year-old woman who presented with symptoms of cholecystitis and obstructive cholangitis. Imaging with magnetic resonance cholangiography using a half-Fourier spinecho sequence, we were able to visualize rapidly and non-invasively a severely abnormal gallbladder, evidence of liver parenchymal inflammation, and biliary duct dilatation.
Contact point identification in multi-fingered grasps exploiting kinematic constraints (2003)

Most of the algorithms used in grasp planning, force optimization and control of multifingered hands need information about the points of contact with a grasped object as well as the normal of the surface in the contact point. With no image processing, this information is gained from tactile sensor arrays, multidimensional force/torque sensors or a priori knowledge. This paper presents a method for those cases, when no good quality sensors are present or measurements are to be improved by sensor fusion. An algorithm is developed to determine the contact points and inherently the surface normal from only joint angle sensors and a geometric description of the fingertip in the 3D case. This is done by observing the constrained motion of fingers securely grasping an object.
Alternative micromachining approaches for the realization of robust MEMS (2000)

This work describes efforts in the fabrication and testing of robust microelectromechanical systems (MEMS). Robustness is typically achieved by investigating non-silicon substrates and materials for MEMS fabrication. Some of the traditional MEMS fabrication techniques are applicable to robust MEMS, while other techniques are drawn from other technology areas, such as electronic packaging. The fabrication tcchnologics appropriate for robust MEMS arc illustrated through three examples: wireless micromachined ceramic pressure sensors for high temperature application in turbine compressors; micromachined stainless steel pressure sensor arrays; and micromachined stainless steel modulators for synthetic jets intended for aerodynamic control applications.
A 60 GHz four channel beamforming transmitter in 0.25 μm SiGe BiCMOS technology (2011)

A four channel 60 GHz beamforming transmitter based on an RF phase shifting architecture is developed fabricated in a SiGe BiCMOS process. The transmitter includes an integrated 48 GHz frequency synthesizer, an up-conversion mixer, and a fully differential millimeter-wave power division and distribution network. Each channel consists of a 2 bit digitally controlled phase shifter and a high power amplifier. The transmitter has approximately 17 dB conversion gain per channel. The maximum saturated RF output power is 15.8 dBm. Each channel dissipates 600 mW.
Low‐Temperature and High‐Strain Rate Superplastic Zirconia (2003)

A superplastic ceramic with a strain rate comparable to metals based on 3% Y 2 O 3 ‐doped tetragonal zirconia (3YTZ) was synthesized at relatively low temperature, based on the doping with MgO and TiO 2 . The desirable material properties result from both a refined preparation procedure for the zirconia, and from enhanced cation lattice diffusion due to the MgO and TiO 2 doping.
IMPATH: Microcomputer Assessment of Behavioral and Psychosocial Factors in Craniomandibular Disorders (1987)

Assessment of behavioral and psychosocial factors in patients with craniomandibular disorders is a complex and time consuming task that, if neglected, will negatively affect the outcome of treatment. IMPATH: TMJ is a psychometric instrument that is designed to improve the efficiency, comprehensiveness, and reliability of identifying behavioral and psychosocial factors, reviewing illness and medical history, and determining the severity of symptoms and the impact of the problem on the patient's life. Administration of IMPATH is accomplished interactively by the patient on a microcomputer. The program automatically provides an immediate analysis and reporting of the results as well as establishes a database for clinical research. This paper describes the characteristics and development of IMPATH: TMJ and highlights its use as part of a comprehensive evaluation of a patient with a craniomandibular disorder.
A Privacy-preserving Decentralized Algorithm for Distribution Locational Marginal Prices (2022)

A major challenge in today’s electricity system is the management of flexibilities offered by new usages, such as smart home appliances or electric vehicles. By incentivizing energy consumption profiles of individuals, demand response seeks to adjust the power demand to the supply, for increased grid stability and better integration of renewable energies. This optimization of flexibility is typically managed by Load Aggregators, independent entities which aggregate and optimize numerous flexibility providers. The consideration of the underlying distribution network constraints, which couple the different actors, leads to a complex multi-agent problem. To address it, we propose a new decentralized algorithm that solves a convex relaxation of the classical Alternative Current Optimal Power Flow (ACOPF) problem, and which relies on local information only. Each computational step is performed in a privacy-preserving manner, and system-wide coordination is achieved via node-specific distribution locational marginal prices (DLMPs). We demonstrate the efficiency of our approach on a 15-bus radial distribution network.
Morphology Control of Tantalum Carbide Nanoparticles through Dopant Additions (2021)

The control of powder morphology in metals and ceramics is of critical importance in applications such as catalysis and chemical sensing whereby specific crystal facets better facilitate chemical r...
Relationship of Surface Area of pH-Dependent Suspensions and Water Retention (1987)

The equilibrium water retention, MW/MS, of suspensions having a pH-dependent surface charge (carbonate-containing aluminum hydroxide and fumed silica) appears to be due to water adsorbed by the surface as well as water retained in pores. The water retained in pores has a lower limit determined by the closest packing porosity. Maximal water retention occurred when the pH was equal to the point of zero charge and attractive particle interactions predominated. The contribution of pore water to MW/MS can be minimized by selecting a pH significantly different from the point of zero charge. The water retention properties of the suspension under these conditions are believed to be due to adsorption and the closest packing porosity. Preliminary results indicate that this MW/MS can be related to the surface area of the suspended solid.
Local Area Networks (1989)

From the Publisher:
This book is an introductory course in analysis of local area networks or computer networks. Its primary market is in electrical engineering,although the course is also taught in computer science departments. A major feature of the text is that it covers both performance analysis and implementation considerations.