gebhart/patrepeval huggingface dataset:
Characteristics of a protease ofStreptococcus sanguisG9B which degrades the major salivary adhesin (1989)

An endogenous enzyme present in cell surface extracts of Streptococcus sanguis strain G9B degraded the major salivary adhesin of the organism.The enzyme showed optimal activity between 50 and 65 C and was inactivated at higher temperatures.The activity at these unusually high temperatures seemed to be a consequence of release from the cell surface since intact whole G9B cells showed greater activity at 37C.The enzyme was not found in culture supernatants of G9B cells.The pH range for the enzyme was between 5 and 9.It was inhibited by iodoacetic acid, Hg 2+, Cu 2, EDTA, SDS, and PMSF, but not by TLCK, TPCK, soybean trypsin inhibitor, cysteine, dithiothreitol, leupeptin, Ca 2+, Mg 2+ or saliva.The enzyme did not show any activity against human or rabbit IgG or human IgA.
Proximal Algorithms (2014)

Proximal Algorithms discusses proximal operators and proximal algorithms, and illustrates their applicability to standard and distributed convex optimization in general and many applications of recent interest in particular. Much like Newton's method is a standard tool for solving unconstrained smooth optimization problems of modest size, proximal algorithms can be viewed as an analogous tool for nonsmooth, constrained, large-scale, or distributed versions of these problems. They are very generally applicable, but are especially well-suited to problems of substantial recent interest involving large or high-dimensional datasets. Proximal methods sit at a higher level of abstraction than classical algorithms like Newton's method: the base operation is evaluating the proximal operator of a function, which itself involves solving a small convex optimization problem. These subproblems, which generalize the problem of projecting a point onto a convex set, often admit closed-form solutions or can be solved very quickly with standard or simple specialized methods. Proximal Algorithms discusses different interpretations of proximal operators and algorithms, looks at their connections to many other topics in optimization and applied mathematics, surveys some popular algorithms, and provides a large number of examples of proximal operators that commonly arise in practice.
Unusual strain-dependent thermal conductivity modulation of silver nanoflower-polyurethane fibers (2018)

Thermal management of stretchable and wearable electronic devices is an important issue in enhancing performance, reliability, and human thermal comfort. Here, we constructed a unique experimental setup which investigated the strain-dependent thermal conductivity. The thermal conductivity of flower-shaped silver nanoparticle (silver nanoflower)-polyurethane (Ag-PU) composite fibers was systematically investigated as a function of strain. The strain-dependent temperature distribution of the Joule-heated fiber was measured using an infrared camera, and the thermal conductivity was obtained from the 1-dimensional Fourier's conduction model. There was a monotonic decrease in both lattice and electronic thermal conductivity with stretching at 25 °C. However, there was an initial increase in lattice and total thermal conductivity in the low strain region (<10%), when the fiber was stretched at 45 °C, although the electronic thermal conductivity decreased monotonically. The softening of the polymer at increased temperatures enhanced Poisson's ratio. Resultantly, the fiber cross-sectional area and radial-direction inter-particle distance between silver nanoflowers decreased. This could increase the thermal transport in conductive fibers by modulating the interfaces between silver nanoflowers and polyurethane. A further stretching decreased the lattice thermal conductivity due to the significantly increased axial distance between silver nanoflowers and the decreased filler fraction. The weft-knitted fabric also demonstrated an increased thermal conductance in the low strain region (≤30%) at 45 °C.
New resin system for low‐pressure moulding compounds with special properties (1990)

Abstract Moulded materials produced from aromatic epoxide resins, aromatic polyamines with high‐temperature‐resistant structure units and powdered mineral fillers possess outstanding properties like high glass transition temperatures, high mechanical strength, low linear thermal expansion coefficient, and reduced flammability without the addition of flame retardants. An account is given of the synthesis of aromatic polyamines, the preparation and working of moulding materials and the properties of the finished products.
Single-chip condenser miniature microphone with a high sensitive circular corrugated diaphragm (2003)

A novel single-chip condenser miniature microphone with a circular corrugated diaphragm for residual stress releasing has been proposed, fabricated and tested. The condenser microphone consists of a rigid single-crystal backplate and a flexible circular corrugated diaphragm using induced couple plasma (ICP) etching. An electrostatic-structural coupling finite element analysis (FEA) was performed for design optimization. A sensitivity of 40 mv/Pa up to 15 KHz has been achieved under a low bias voltage of 14 V, which is among the best in the presented reports.
ChemInform Abstract: Multiply Convergent Syntheses via Conjugate‐Addition Reactions to Cycloalkenyl Sulfones (1987)

ChemInformVolume 18, Issue 10 Reviews ChemInform Abstract: Multiply Convergent Syntheses via Conjugate-Addition Reactions to Cycloalkenyl Sulfones P. L. FUCHS, P. L. FUCHS Chem. Dep., Purdue Univ., West Lafayette, IN 47907, USASearch for more papers by this authorT. F. BRAISH, T. F. BRAISH Chem. Dep., Purdue Univ., West Lafayette, IN 47907, USASearch for more papers by this author P. L. FUCHS, P. L. FUCHS Chem. Dep., Purdue Univ., West Lafayette, IN 47907, USASearch for more papers by this authorT. F. BRAISH, T. F. BRAISH Chem. Dep., Purdue Univ., West Lafayette, IN 47907, USASearch for more papers by this author First published: March 10, 1987 https://doi.org/10.1002/chin.198710366Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume18, Issue10March 10, 1987 RelatedInformation
Is the fusion process the basis for growth, repair and aging? (1991)

Jacobson resonance sets in dual resonance electromagnetic interaction energies and gravitational potential. It states the equivalence mc2 = Bvl coulomb, where 1 is length of a biological string and v is the Galilean inertial velocity of said string through flux density B. The coulomb is a single unit of charge while c is the velocity of light. m is a quantum genetic or associated character contained as a ponderable body of mass within biological string. Jacobson resonance shows the possibility that within the framework of the human body physiological magnetic fields perhaps regulate crystalline lattices of critical molecules and, indeed, even deuterium atoms necessary for fusion; whereby the fusion process is thought to occur to promulgate physiological homeostasis via the production of energy in both chemical and physical processes. Said production of energy through the maintenance of crystalline lattice structure regulation may control growth, repair and aging. A clear model is given to explain how physiological magnetic fields function in multiple harmonic interactions, as well as how intrinsic biological electromagnetic fields (IBEMF's) are created by interaction of biological conductive string and the geomagnetic field.
Heat-and-Electricity-Supply-System for Manned Spacecraft Using Nuclear Power (2006)

In order to explore the deep space, such as Mars, Jupiter, Saturn, etc in the future, a spacecraft that will be driven by nuclear power should be developed.
New approaches to handle old compounds – the generation of microcystin and nodularin derivatives with “clickable” features (2017)

Lately, new crosslinking techniques have been developed to study the function of compounds in cellular processes. These techniques became known as bioorthogonal or so-called “click” reactions [1]. They are biorthogonal because they involve functional groups not found in nature. Thus, a semisynthetic approach is required to introduce the “clickable” groups into natural products – a sometimes difficult and time-consuming process.
Risk and Risk Score Performance of Hepatocellular Carcinoma Development in Patients With Hepatitis B Surface Antigen Seroclearance (2021)

AVT-induced HBsAg seroclearance was associated with higher HCC risk, especially for patients with cirrhosis, indicating that they need careful monitoring for HCC risk. The HCC risk models were able to stratify the HCC risk in patients with HBsAg seroclearance.
Ballistic Hall micromagnetometry (1997)

We report a magnetization measurement technique which allows quantitative studies of thermodynamic properties of individual submicron superconducting and ferromagnetic particles.
Down-regulation of the MHC class I antigen-processing machinery after oncogenic transformation of murine fibroblasts (1998)

Malignant transformation is often associated with genetic alterations providing tumor cells with mechanisms for escape from immune surveillance. Human and murine tumors of various origin as well as in vitro models of viral and oncogenic transformation express reduced levels of major histocompatibility complex (MHC) class I antigens resulting in decreased sensitivity to MHC class I-restricted cytotoxic T lymphocyte (CTL)-mediated lysis. We here investigate whether the suppressed MHC class I surface expression of ras-transformed fibroblasts is due to dysregulation of the genes of the antigen-processing machinery, the peptide transporters TAP-1 and TAP-2 and the proteasome subunits LMP-2 and LMP-7, and whether it can be restored by gene transfer. In comparison to parental NIH3T3 cells, the ras oncogenic transformants revealed reduced TAP and LMP mRNA expression and impaired function of these genes, leading to deficient peptide transport and peptide loading of MHC class I molecules resulting in instable expression of the MHC class I complex on the cell surface. Enhanced H-2 surface expression due to stabilization of the MHC class I complex could be achieved by culturing ras transformants at low, unphysiological temperature (26 degrees C) or by loading these cells with either exogenous human beta2-microglobulin or MHC class I-binding peptide alone or in combination. Furthermore, interferon-gamma treatment was capable to enhance the expression of TAP, LMP and MHC class I molecules in both parental as well as ras-transformed fibroblasts. Stable transfection of the human TAP-1 cDNA into ras transformants caused a partial reconstitution of the peptide transport and an enhancement of the MHC class I surface expression, whereas the level of MHC class I biosynthesis was not affected by TAP-1 overexpression in parental cells. Together these results point to the existence of an association between oncogenic transformation and deficiencies in the MHC class I antigen-restricted immunosurveillance, suggesting intervention strategies involving specific MHC class I-binding peptides or transfection of the LMP and/or TAP genes to overcome the expression of the immune escape phenotype.
Cyclosporin A stimulates proliferation of the liver cells after partial hepatectomy in rats. (1988)

The effects of cyclosporin A (CyA) upon regeneration of the liver were studied in rats after partial hepatectomy. In group 1, a standard two-thirds hepatectomy was performed. In group 2, CyA, a dose of 10 milligrams per kilogram, was given orally one day prior to, on the day of the operation and 24 hours after hepatectomy. The liver weight restoration, histologic findings and mitotic activities of remnant livers and serum levels of aminotransferase, albumin, total bilirubin and creatinine values were examined from 24 hours to ten days after the operation. Treatment with CyA resulted in an increase of the mitotic activities of the hepatocytes, which were twice as high as those in the control group. This phenomenon coincided well with the regenerative rate of remnant livers, histologic factors, albumin synthesis and other biochemical parameters. Our results indicate that CyA has a stimulatory effect upon liver cell proliferation after partial hepatectomy in rats. The augmentative effect of CyA on liver regeneration is discussed.
The adenovirus EII early promoter has multiple EIA-sensitive elements, two of which function cooperatively in basal and virus-induced transcription (1990)

The mechanism by which the adenovirus-encoded nuclear oncogene EIA activates transcription of several viral and host promoters is an important issue in the regulation of eucaryotic gene expression and virus-host cell interactions. Identification of cis-acting elements of the promoters and the cognate host transcription factors that are targets for EIA action is crucial for our understanding of the EIA-mediated control of coordinately regulated genes. The adenovirus EII early promoter has a complex architecture and contains two overlapping promoters with start sites at +1 (major promoter) and -26 (minor promoter). The major promoter responds strongly to virus-encoded trans activators EIA and EIV and contains four elements: a TAGA motif analogous to the TATA box, two EIIF sites present in an inverted orientation, and an ATF/CREB site. To determine precisely the roles played by these cis-acting elements in both basal and virus-induced transcription when the promoter is situated in its natural context, we investigated the phenotype of a series of linker scan promoter substitution mutants inserted into the viral chromosome. Promoter constructs harboring linker scan mutations in each element were rebuilt into a novel EIA- adenovirus vector, and transcriptional activity was monitored in virus-infected cells. In the absence of virus-encoded trans activators, basal activity in vivo was dependent on all four cis-acting elements. Surprisingly, a promoter mutant with only one of the two EIIF sites intact could not promote transcription in vivo, suggesting that the two EIIF sites function cooperatively even in basal transcription. Promoters harboring mutations in either of these two EIIF sites also failed to bind to an infection-specific form of EIIF in gel shift assays and competed only very weakly for EIIF binding with the wild-type promoter fragment. The dramatic cooperativity shown by the two inverted EIIF sites of the EII promoter both in vivo and in vitro could reflect simultaneous contact of both sites by the transcription factor EIIF. Furthermore, promoter mutants with mutations in the TAGA motif, the two EIIF sites, and the single ATF site all failed to respond to virus-encoded trans activators. Whereas recent results demonstrate that EIIF activity can be modulated independently by EIV, leading to transactivation of this promoter, our results and those published previously strongly indicate that the three different transcription factors that bind to TAGA, EIIF, and ATF motifs of the EII early promoter are all targets for EIA regulation in vivo. Thus, strong transactivation of the EII early promoter through these multiple EIA-sensitive elements and independently by the recently discovered EIV pathway suggests that the EII early promoter is stringently regulated in virus-infected cells.(ABSTRACT TRUNCATED AT 400 WORDS)
Competition Law for a Post-Scarcity World (2016)

Writers, economists and IP scholars have hailed signs of an incipient shift to a post-scarcity world. Driving this change are rapid decreases not only in marginal cost, but also in the fixed or first-unit costs of production. Whether these changes become economy-wide, or remain confined to a subset of industries, they have dramatic implications for competition law and policy. This Article is the first to address these implications. In particular, because of the incentive for incumbent firms to engage in what may be termed “anti-disruption” – as examples such as the Apple/e-books antitrust case and the regulatory responses to Uber show – competition law must play an active role in assisting the transition to a post-scarcity world. Playing this role will not be simple, but the welfare gains of this societal shift make it impossible to ignore.
The impact of gender, medical history and vital status on emergency visits and hospital admissions: A remote patient monitoring case study (2017)

Remote Program Monitoring (RPM) is considered to have potential to improve the quality of life on patients diagnosed with cardiac conditions such as heart failure (HF) and chronic obstructive pulmonary disease (COPD). Remote collection and analysis of patients data could aid in effective decision making on necessary care needed by patients monitored. This could lead to reduction on healthcare costs as well as improved outcomes for the patients. As a component of our predictive analytics research, this paper presents results of remote patient monitoring study of patients from the Cardiac Clinic of Southlake Regional Health Centre who were referred to WeCare for home based monitoring. Results indicate statistically significant evidence on impact of gender, medical history and vital status as risk factors for subsequent hospitalization and multiple emergency room visits.
Psychopathology during childhood and adolescence predicts delusional-like experiences in adults: A 21 year birth cohort study (2008)

Objective: Community surveys have shown that many otherwise well individuals report delusional-like experiences. The authors examined psychopathology during childhood and adolescence as a predictor of delusional-like experiences in young adulthood.
Emerging Functions of Natural IgM and Its Fc Receptor FCMR in Immune Homeostasis (2016)

Most natural IgM antibodies are encoded by germline Ig sequences and are produced in large quantities by both mice and humans in the absence of intentional immunization. Natural IgM are reactive with many conserved epitopes, including those shared by microorganisms and autoantigens. As a result, these antibodies play important roles in clearing intruding pathogens, as well as apoptotic/necrotic cells and otherwise damaged tissues. While natural IgM binds to target structures with low affinity due to a lack of significant selection by somatic hypermutation, its pentameric structure with 10 antigen-binding sites enables these antibodies to bind multivalent target antigens with high avidity. Opsonization of antigen complexed with IgM is mediated by cell surface Fc receptors. While the existence of Fc alpha/mu receptor has been known for some time, only recently has the Fc receptor specific for IgM (FCMR) been identified. In this review, we focus on our current understandings of how natural IgM and FCMR regulate the immune system and maintain homeostasis under physiological and pathological conditions.
Coherent Receiver Photonic Integrated Circuits (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Schell, H. G. Bach, K. Janiak, N. Keil, M. Möhrle, P. Runge, and Z. Zhang, "Coherent Receiver Photonic Integrated Circuits," in Optical Fiber Communication Conference/National Fiber Optic Engineers Conference 2013, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper OW3J.6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
MRI appearance of adjunct surgical material used in spine surgery (2021)

Knowledge about MRI appearances of commonly used adjunct surgical materials helps in interpretation of postoperative imaging and supports clinical decision making.
ANÁLISE COMPARATIVA DE TEMPO DO TRATAMENTO RESTAURADOR ATRAUMÁTICO (ART) CONVENCIONAL E MODIFICADO COM GEL DE PAPACÁRIE (2013)

O propositodeste ensaio clinico foi realizar uma analise comparativa entre o tempo detrabalho do Tratamento Restaurador Atraumatico (TRA) convencional e o TRA modificadocom gel de Papacarie®, um gel a base de papaina para a remocao decarie em dentes permanentes. A amostra consistiu de 20 molares permanentes deestudantes com idade entre 06 a 14 anos, com lesao de carie na face oclusal. Otecido cariado foi removido por um operador calibrado utilizando o metodomecânico de escavacao manual (n = 10) e o metodo quimico-mecânico comPapacarie® (n = 10). O tempo de trabalho para a realizacao de ambas as tecnicasfoi cronometrado e ao final, cada cavidade foi restaurada com cimento deionomero de vidro modificado. Observou-se que a remocao do tecido cariado pelo metodo quimico-mecânico demonstrou ter um tempo de trabalho menor do que ometodo convencional, porem sem diferenca estatisticamente significante. Ambosos metodos utilizados foram efetivos na remocao de carie em dentes permanentes.
Nucleic acid isolation (1988)

A method is provided for isolating DNA from eukaryotic cell and flow sorted chromosomes. When DNA is removed from chromosome and cell structure, detergent and proteolytic digestion products remain with the DNA. These products can be removed with organic extraction, but the process steps associated with organic extraction reduces the size of DNA fragments available for experimental use. The present process removes the waste products by dialyzing a solution containing the DNA against a solution containing polyethylene glycol (PEG). The waste products dialyze into the PEG leaving isolated DNA. The remaining DNA has been prepared with fragments containing more than 160 kb. The isolated DNA has been used in conventional protocols without effect on the protocol.
Regional changes in 2‐deoxyglucose uptake associated with neuroleptic‐induced tardive dyskinesia in the cebus monkey (1992)

The neural mechanisms that mediate a primate model of tardive dyskinesia have been investigated using the 2-deoxyglucose (2-DG) uptake technique. Three groups of Cebus monkeys were used. Some of the animals received long-term neuroleptic treatment. These animals were allotted to one of two groups depending on whether they developed tardive dyskinesia or not. A third group of animals served as untreated controls. The neuroleptic-treated dyskinetic animals showed reduced uptake of 2-DG in the medial segment of the globus pallidus and in the ventral anterior (VA) and ventral lateral (VL) nuclei of the thalamus relative to that seen in the equivalent structures in the neuroleptic-treated nondyskinetic and untreated control animals. The data are interpreted as suggesting that tardive dyskinesia is mediated by underactivity of the pathways from the subthalamic nucleus to the medial pallidal segment and the substantia pars nigra pars reticulata, which in turn result in a loss of gamma-aminobutyric acid-ergic inhibition of the VA and VL thalamic nuclei. This suggests that tardive dyskinesia shares a common underlying neural mechanism with other hyperkinesias such as chorea and ballism.