gebhart/patrepeval huggingface dataset:
RNA Interference of the Clock Gene period Disrupts Circadian Rhythms in the Cricket Gryllus bimaculatus (2008)

Periodic expression of so-called clock genes is an essential part of the circadian clock. In Drosophila melanogaster the cyclic expression of per and tim through an autoregulatory feedback loop is believed to play a central role in circadian rhythm generation. However, it is still elusive whether this hypothesis is applicable to other insect species. Here it is shown that per gene plays a key role in the rhythm generation in the cricket Gryllus bimaculatus. Measurement of per mRNA levels in the optic lobe revealed the rhythmic expression of per in light cycles with a peak in the late day to early night, persisting in constant darkness. A single injection of per double-stranded RNA (dsRNA) into the abdomen of the final instar nymphs effectively knocked down the mRNA levels as adult to about 50% of control animals. Most of the per dsRNA-injected crickets completely lost the circadian locomotor activity rhythm in constant darkness up to 50 days after the injection, whereas those injected with DsRed2 dsRNA as a negative control clearly maintained it. The electrical activity of optic lobe efferents also became arrhythmic in the per dsRNA-injected crickets. These results not only suggest that per plays an important role in the circadian rhythm generation also in the cricket but also show that RNA interference is a powerful tool to dissect the molecular machinery of the cricket circadian clock.
Dielectric properties of Eu-doped polycrystalline TbMnO3 (2010)

Polycrystalline bulk Tb0.8Eu0.2MnO3 was prepared by solid phase reaction. The XRD analysis of the sample showed that the Eu3+ had been doped in TbMnO3. Dielectric properties were examined as functions of temperature (100 K ≤T≤ 300 K) and frequency (200 Hz≤ f ≤100 kHz). Two dielectric relaxations were found in these ranges. By means of analysis the low-temperature relaxation was ascribed to the dipolar effects induced by carriers hopping; and the high-temperature relaxation was found to originate from the internal barrier-layer capacitor effects of ion conductivity. The measurement of resistivity showed that there is a marked transition around 230 K, indicating that different conductive mechanisms underlay the transport processes.
Motility-based screening of probiotic bacteria candidates by label-free coherent light tester (2023)

Probiotic bacteria are microbial species known to confer benefits to health. In order to act effectively as probiotics, microencapsulated bacteria have to maintain their viability during the gastro-intestinal transit and their motility to reach epithelial cells of the intestine. Here we use Bio-Speckle Dynamic Assays (BSDA) for rapidly testing the microencapsulation performance in experiments simulating gastro-intestinal conditions. Label-free samples are probed by coherent light to infer ensemble motility information. Then, we use Digital Holography (DH) in transmission microscopy mode and 3D tracking as complementary tools to infer strain-specific locomotion profiles at the single cell level.
Preparation of a novel polymeric copper phthalocyanine containing crown ether moieties and its alkali metal binding property (1987)

Preparation par polymerisation dans la pyridine du systeme tetrabromodibenzo-18 crown-6/CuCN dans un tube scelle
Characterization of the 3D information of Calyptogena shells (2003)

We propose in this paper an application of multiresolution analysis techniques to extract information contained in the growth increments of a bivalve mollusk called: <i>Calyptogena</i>. The first stage consists in extracting a range image of the mollusk’s shell using a 3-D scanner. Applying a multiresolution analysis enables us to localize precisely those growth increments by preserving relevant details. Moreover, interesting spatial and frequency properties of the multiresolution analysis underline information contained on the shell. Intra-individual variation and inter-individual variations are compared to assume some conclusions as for the ontogenetic evolution of the animal such as periodicities, which can be later related to certain regular changes in its environment.
Cutting of a thin epitaxial iron film into low dimensional structures by dislocation engineering (1997)

The “Atomic saw” method, initially developed for semiconductor heterostructures, has been successfully used to fabricate low dimensional iron structures. Dislocations, generated by plastic deformation, are used to cut a 2 nm iron film, epitaxially grown onto a (001) MgO substrate, into one dimensional iron structures (called “stripes”) or zero dimensional structures (called “boxes”). Atomic force microscopy observations of the created magnetic structures demonstrate the applicability of this simple method. A statistical analysis of these observations quantifies the distributions of the widths and the shifts of the created adjacent stripes and reveals that these two parameters can be controlled by the choice of the plastic strain.
Perceiving Illumination Inconsistencies in Scenes (2005)

The human visual system is adept at detecting and encoding statistical regularities in its spatiotemporal environment. Here, we report an unexpected failure of this ability in the context of perceiving inconsistencies in illumination distributions across a scene. Prior work with arrays of objects all having uniform reflectance has shown that one inconsistently illuminated target can 'pop out' among a field of consistently illuminated objects (eg Enns and Rensink, 1990 Science 247 721 723; Sun and Perona, 1997 Perception 26 519-529). In these studies, the luminance pattern of the odd target could be interpreted as arising from either an inconsistent illumination or inconsistent pigmentation of the target. Either cue might explain the rapid detection. In contrast, we find that once the geometrical regularity of the previous displays is removed, the visual system is remarkably insensitive to illumination inconsistencies, both in experimental stimuli and in altered images of real scenes. Whether the target is interpreted as oddly illuminated or oddly pigmented, it is very difficult to find if the only cue is deviation from the regularity of illumination or reflectance. Our results allow us to draw inferences about how the visual system encodes illumination distributions across scenes. Specifically, they suggest that the visual system does not verify the global consistency of locally derived estimates of illumination direction.
Beamforming for MIMO systems with limited feedback (2006)

Beamforming and power allocation at the transmitter are both effective means to improve the performance of multiple input multiple output (MIMO) system. They are both dependent on the channel state information (CSI). We propose a scheme including optimal beamforming and power allocation in which the CSI at the transmitter is obtained through limited feedback. Two codebooks of beamforming matrices and power allocation vectors are constructed offline and both known by the transmitter and the receiver. Using the MMSE criterion, we choose the optimal variables from the codebooks. The data to convey to the transmitter are the indexes of the variables. We validate the proposed scheme by computer simulations from which we see the scheme can achieve a fine performance with several bits of feedback. (3 pages)
Combination of hydrophobicity and codon usage bias determines sorting of model K + channel protein to either mitochondria or endoplasmic reticulum (2023)

When the K<sup>+</sup> channel-like protein Kesv from Ectocarpus siliculosus virus 1 is heterologously expressed in mammalian cells, it is sorted to the mitochondria. This targeting can be redirected to the endoplasmic reticulum (ER) by altering the codon usage in distinct regions of the gene or by inserting a triplet of hydrophobic amino acids (AAs) into the protein's C-terminal transmembrane domain (ct-TMD). Systematic variations in the flavor of the inserted AAs and/or its codon usage show that a positive charge in the inserted AA triplet alone serves as strong signal for mitochondria sorting. In cases of neutral AA triplets, mitochondria sorting are favored by a combination of hydrophilic AAs and rarely used codons; sorting to the ER exhibits the inverse dependency. This propensity for ER sorting is particularly high when a common codon follows a rarer one in the AA triplet; mitochondria sorting in contrast is supported by codon uniformity. Since parameters like positive charge, hydrophobic AAs, and common codons are known to facilitate elongation of nascent proteins in the ribosome the data suggest a mechanism in which local changes in elongation velocity and co-translational folding in the ct-TMD influence intracellular protein sorting.
In-vitro bioequivalence study of 8 brands of metformin tablets in Iran market (2012)

Bioequivalence studies are the commonly accepted methods displaying therapeutic equivalence between two products .This study was conducted to evaluate the bioequivalence between different formulations of metformin 500 mg and 1000 mg tablets which were marketed in Iran, and innovator brand. Considering that only in vitro bioequivalence studies can predict the in vivo bioequivalence, and to save time and cost, three essential in vitro tests including assay, weight variation and a comparative in vitro dissolution study were performed. In order to compare formulations, dissolution profiles were taken and compared through two model independent methods, difference factor (f1) and similarity factor (f2). All the tested brands released more than 80% drug in 30 minutes and contained 95-96.3% of labeled amount except b and C. The acceptance value in all cases were below 15. Therefore it is evident that test products except brand C were bioequivalent to the reference product, and could be used as a generic substitute for the innovator product. Results emphasize to need for post marketing investigation for new formulations.
Digital Coincidence Processing for the RatCAP Conscious Rat Brain PET Scanner (2006)

The RatCAP has been designed and constructed to image the awake rat brain. In order to maximize system performance, offline digital coincidence data processing algorithms including offset delay correction and prompt and delayed coincidence detection have been developed and validated. With offset delay correction using a singular value decomposition (SVD) technique, overall time resolution was improved from 32.6 ns to 17.6 ns FWHM. The experimental results confirm that the ratio of prompts (or trues) to randoms was improved because a smaller timing window could be used. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> F-fluoride rat bone scan data was reconstructed with our fully 3-D MLEM with a highly accurate detector response model using Monte Carlo simulation.
<title>Substrate noise coupling: a pain for mixed-signal systems (Keynote Address)</title> (2005)

Crosstalk from digital to analog in mixed-signal ICs is recognized as one of the major roadblocks for systems-on-chip (SoC) in future CMOS technologies. This crosstalk mainly happens via the semiconducting silicon substrate, which is usually treated as a ground node by analog and RF designers. The substrate noise coupling problem leads more and more to malfunctioning or extra design iterations. One of the reasons is that the phenomenon of substrate noise coupling is difficult to model and hence difficult to understand. It can be caused by the switching of thousands or millions of gates and depends on layout details. From the generation side (the digital domain), coping with the large amount of noise generators can be solved by macromodeling. On the other hand, the impact of substrate noise on the analog circuits requires careful modeling at the level of transistors and parasitics of layout, power supply, package, PCB, Comparison to measurements of macromodeling at the digital side and careful modeling at the analog side, shows that both the generation and the impact of substrate noise can be predicted with an accuracy of a few dB. In addition, this combination of macromodeling at the digital side and careful modeling at the analog side leads to an understanding of the problem, which can be used for digital low-noise design techniques to minimize the generation of noise, and substrate noise immune design of analog/RF circuits.
Train-Ground Communication in CBTC Based on 802.11b: Design and Performance Research (2009)

The 802.11b physical protocols applied in Communication Based Train Control (CBTC) train-ground communication system are simulated in this paper, and the simulation result is used to determine the AP distance. The train speed impact on physical FER is also studied by the simulation result. As a protocol used in a fully mobile outdoor environment, the packet delay and packets loss rate performance of 802.11 DCF is analyzed at last.
Hypercorroles Formed via the Tail that Wagged the Dog: Charge Transfer Interactions from Innocent Corroles to Meso-Nitrophenyl Substituents (2022)

A series of cobalt nitrophenylcorroles were spectrally characterized in CH<sub>2</sub>Cl<sub>2</sub>, and under certain solution conditions, several compounds were shown to exhibit hypercorrole spectra resulting from charge transfer interactions from the corrole π-system to the redox-active <i>meso</i>-NO<sub>2</sub>Ph substituents. The resulting spectral pattern has not previously been reported for metallocorroles and in the case of the cobalt derivatives was shown to depend upon the number and position of the <i>meso</i>-nitrophenyl groups on the macrocycle, the position of the NO<sub>2</sub> substituent on the <i>meso</i>-phenyl ring(s) (<i>para</i> or <i>meta</i>), and the electronic structure of the corrole, which can exist in its innocent or noninnocent form depending in large part upon the type and number of axial ligands. Cobalt corroles bearing <i>p</i>-nitrophenyl groups at the 5,15- or 5,10,15-positions of the macrocycle exhibited the most marked hypercorrole spectra under solution conditions where the complex was innocent (i.e., Cor<sup>3-</sup>Co<sup>III</sup>), and a systematic analysis of the spectral data suggests the root of this perturbation to be a corrole-to-aryl interaction (i.e., ligand-to-ligand charge transfer or LLCT). The largest interaction between the π-system and the NO<sub>2</sub>Ph substituents was seen upon coordination of anionic cyanide (CN<sup>-</sup>) axial ligands to the Co(III) center of the bis-(CN<sup>-</sup>)-5,15-dinitrophenyl derivative, resulting in a cobalt hypercorrole spectrum where the broad Q-band was red-shifted even further into the NIR region and located at 795 nm in CH<sub>2</sub>Cl<sub>2</sub> and 827 nm in pyridine. Cyclic voltammetry of the bis-CN<sup>-</sup> adducts showed that the first electrons are added to the LUMOs of the <i>p</i>-NO<sub>2</sub>Ph substituents rather than the corrole, while the same orbitals for the mono-CN<sup>-</sup> adducts are nearly degenerate. This redox behavior contrasts with what is seen for the noninnocent nitrophenyl corroles having "normal" unperturbed UV-vis spectra where the first reduction involves the π-system of the macrocycle, followed by reduction of the <i>p</i>-NO<sub>2</sub>Ph groups at more negative potentials.
Vapor Pressures of Liquids as a Function of Temperature. Two-Parameter Equation Based on Kinetic Theory of Fluids (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleVapor Pressures of Liquids as a Function of Temperature. Two-Parameter Equation Based on Kinetic Theory of FluidsA. B. Macknick, J. Winnick, and J. M. PrausnitzCite this: Ind. Eng. Chem. Fundamen. 1977, 16, 3, 392Publication Date (Print):August 1, 1977Publication History Published online1 May 2002Published inissue 1 August 1977https://pubs.acs.org/doi/10.1021/i160063a019https://doi.org/10.1021/i160063a019research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The corporate choice (2009)

In a 2007 exhibition at International Print Center New York Sandra Lang looked at eight of the USA's leading corporate art collections with significant print holdings and which remain major players today.
Essential Role for the Major Autolysin in the Fibronectin-Binding Protein-Mediated Staphylococcus aureus Biofilm Phenotype (2010)

Staphylococcus aureus clinical isolates are capable of producing at least two distinct types of biofilm mediated by the fibronectin-binding proteins (FnBPs) or the icaADBC-encoded polysaccharide intercellular adhesin (PIA). Deletion of the major autolysin gene atl reduced primary attachment rates and impaired FnBP-dependent biofilm production on hydrophilic polystyrene in 12 clinical methicillin-resistant S. aureus (MRSA) isolates but had no effect on PIA-dependent biofilm production by 9 methicillin-susceptible S. aureus (MSSA) isolates. In contrast, Atl was required for both FnBP- and PIA-mediated biofilm development on hydrophobic polystyrene. Here we investigated the role of Atl in biofilm production on hydrophilic polystyrene. The alternative sigma factor σ(B), which represses RNAIII expression and extracellular protease production, was required for FnBP- but not PIA-dependent biofilm development. Furthermore, mutation of the agr locus enhanced FnBP-dependent biofilm development, whereas a sarA mutation, which increases protease production, blocked FnBP-mediated biofilm development. Mutation of sigB in MRSA isolate BH1CC lowered primary attachment rates, in part via reduced atl transcription. Posttranslational activation or inhibition of Atl activity with phenylmethylsulfonyl fluoride and polyanethole sodium sulfonate or mutation of the Atl amidase active site interfered with lytic activity and biofilm development. Consistent with these observations, extracellular DNA was important for the early stages of Atl/FnBP-dependent biofilm development. Further analysis of atl regulation revealed that atlR encodes a transcriptional repressor of the major autolysin and that an atlR::Tc(r) mutation in BH1CC enhanced biofilm-forming capacity. These data reveal an essential role for the major autolysin in the early events of the FnBP-dependent S. aureus biofilm phenotype.
Supplementary Figures 1-5 from Inhibition of the Peptidyl-Prolyl-Isomerase Pin1 Enhances the Responses of Acute Myeloid Leukemia Cells to Retinoic Acid via Stabilization of RARα and PML-RARα (2023)

Supplementary Figures 1-5 from Inhibition of the Peptidyl-Prolyl-Isomerase Pin1 Enhances the Responses of Acute Myeloid Leukemia Cells to Retinoic Acid via Stabilization of RARα and PML-RARα
A hierachical configuration system for a massively parallel neural hardware platform (2012)

Simulation of large networks of neurons is a powerful and increasingly prominent methodology for investigate brain functions and structures. Dedicated parallel hardware is a natural candidate for simulating the dynamic activity of many non-linear units communicating asynchronously. It is only scientifically useful, however, if the simulation tools can be configured and run easily and quickly. We present a method to map network models to computational nodes on the SpiNNaker system, a programmable parallel neurally-inspired hardware architecture, by exploiting the hierarchies built in the model. This PArtitioning and Configuration MANager (PACMAN) system supports arbitrary network topologies and arbitrary membrane potential and synapse dynamics, and (most importantly) decouples the model from the device, allowing a variety of languages (PyNN, Nengo, etc.) to drive the simulation hardware. Model representation operates on a Population/Projection level rather than a single-neuron and connection level, exploiting hierarchical properties to lower the complexity of allocating resources and mapping the model onto the system. PACMAN can be thus be used to generate structures coming from different models and front-ends, either with a host-based process, or by parallelising it on the SpiNNaker machine itself to speed up the generation process greatly. We describe the approach with a first implementation of the framework used to configure the current generation of SpiNNaker machines and present results from a set of key benchmarks. The system allows researchers to exploit dedicated simulation hardware which may otherwise be difficult to program. In effect, PACMAN provides automated hardware acceleration for some commonly used network simulators while also pointing towards the advantages of hierarchical configuration for large, domain-specific hardware systems.
Polypropylene Nanocomposites Containing Multi-walled Carbon Nanotubes and Graphene Oxide by Ziegler-Natta Catalysis (2019)

Polymer nanocomposites containing carbon nanotubes, graphenes, and layered silicates have been shown with significant improvement in various material properties including mechanical, thermal, electrical, and gas barrier properties. Polymer nanocomposites can generally be accessed through two routes: direct polymer/nano filler combination and in situ monomer polymerization on the surfaces of the nano fillers. The preparation of polypropylene (PP)/carbon nanotube (CNT) nanocomposites by in situ polymerization technique has been generally conducted following W., A. Kaminsky’s approach, with the use of metallocene catalyst system. For in situ preparation of PP/CNTs nanocomposites, there have been few examples of using the more convenient Ziegler-Natta catalyst system to undertake the task of generation of isospecific polymerization active sites on CNTs surface. The chapter summarizes the synthesis of PP-based nanocomposites containing multi-walled carbon nanotubes and graphene oxide as nanofillers using the technically challenging yet economically favorable in situ polymerization approach. With methylaluminoxane heterogenized by CNTs, polymerization active sites are formed on the surface of CNTs.