gebhart/patrepeval huggingface dataset:
SPINAL STENOSIS DECOMPRESSION AND COFLEX™ INTERSPINOUS STABILIZATION: RESULTS FROM AN INTERNATIONAL MULTICENTER RETROSPECTIVE STUDY (2008)

Objective: The purpose of this study was to determine the safety and efficacy and evaluate several radiographic parameters after implantation of coflex™ for the primary diagnosis of spinal stenosis (1 or 2 levels) in patients with neurogenic claudication and low back pain between the ages of 40 and 80 years old. Methods: Retrospective data were gathered on 589 patients from 5 sites with 429 patients having contemporaneous clinical and radiographic follow-up. Clinical analysis was performed on 209 patients with spinal stenosis using VAS and objective examination measures to determine safety and efficacy of the coflex in relieving neurogenic claudication, radiculopathy and back pain. The median follow-up was 20 months (range 6 to 121 months) For the 209 patients, radiographic data was collected for evaluation of spinal segment motion (index and adjacent levels), implant position, migration and bony remodeling at the bone-implant interface. All device complications were recorded and independently reviewed by Medical Metrics, Inc. (Houston, TX) and an independent orthopaedic spinal surgeon (KP). Results: Moderate to severe low back pain improved in 75% of patients, while leg pain improved in 88% of patients. Claudication improved in 91% of patients and improvement in walking distance occurred in 79% of the patients. These results were achieved at 1 year and did not deteriorate over the long-term. Patient satisfaction was 88%. Complete radiographs with excellent quality were available for 180 implanted coflex devices. Sagittal rotation and translation measurements were essentially the same for all diagnoses, follow-up time points and levels of implantation. No expulsions and only 1 migration (>5 mm) was observed. Mild and moderate bone-implant interface remodeling was noted in 15.4 %. No broken or permanently deformed implants were noted. Conclusions: coflex interspinous stabilization after microsurgical decompression for spinal stenosis demonstrates excellent short term and long term results for back pain, neurogenic claudication and patient satisfaction.
Synthesis and Characterization of MIL-79 and MIL-80:  Two New Luminescent Open-Framework Rare-Earth Dicarboxylates with Unusual 1D Inorganic Subnetworks (2004)

Two new three-dimensional europium(III) dicarboxylates, MIL-79 or Eu(III)5(OH)9(H2O)6(O2C−C2H2−CO2)3·9.5H2O, and MIL-80 or EuIII4(OH)4(H2O)5(O2C−C2H2−CO2)4·4H2O, have been obtained under hydrothermal conditions. Both structures, which have been determined using either X-ray powder or single-crystal diffraction data, are built-up from unusual complex chains made from clusters of eight-, nine-, and ten-coordinated europium(III) polyhedra linked through fumarate and maleate dianions. This creates three-dimensional structures with either 1-D large elongated pore channels (MIL-79) or cages (MIL-80) filled in both cases with free water molecules which interact with terminal water molecules or apical oxygen atoms from the carboxylates. The thermal behavior of MIL-79 has been investigated using TGA and X-ray thermodiffractometry and reveals that its dehydration leads to an irreversible pore contraction. Study of the luminescence properties of the yttrium(III) form of MIL-79 doped with europium(III) reveals a significant red-emission upon VUV radiation. Crystal data for MIL-79: monoclinic space group C2/m with a = 25.954(1) Å, b = 11.014(1) Å, c = 13.247(1) Å, β = 119.162(1)°, and Z = 4. Crystal data for MIL-80: triclinic space group P1̄ with a = 10.5770(2) Å, b = 10.6164(2) Å, c = 14.9403(3) Å, α = 91.624(1)°, β = 91.120(1)°, γ = 113.892(1)°, and Z = 2.
Selective In-Context Data Augmentation for Intent Detection using Pointwise V-Information (2023)

This work focuses on in-context data augmentation for intent detection. Having found that augmentation via in-context prompting of large pre-trained language models (PLMs) alone does not improve performance, we introduce a novel approach based on PLMs and pointwise V-information (PVI), a metric that can measure the usefulness of a datapoint for training a model. Our method first fine-tunes a PLM on a small seed of training data and then synthesizes new datapoints - utterances that correspond to given intents. It then employs intent-aware filtering, based on PVI, to remove datapoints that are not helpful to the downstream intent classifier. Our method is thus able to leverage the expressive power of large language models to produce diverse training data. Empirical results demonstrate that our method can produce synthetic training data that achieve state-of-the-art performance on three challenging intent detection datasets under few-shot settings (1.28% absolute improvement in 5-shot and 1.18% absolute in 10-shot, on average) and perform on par with the state-of-the-art in full-shot settings (within 0.01% absolute, on average).
External motion tracking for brain imaging: Structured light tracking with invisible light (2010)

The importance of motion correction in 3D medical imaging increases with increasing scanner resolution. It is necessary for scanners with long image acquisition and low contrast images to correct for patient motion in order to optimize image quality. We present a near infrared structured light stereo depth map system for head motion estimation inside 3D medical scanners with limited space.
Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1. (2005)

International audience
Evidence for the Role of Reactive Nitrogen Species in Polymicrobial Sepsis-Induced Renal Peritubular Capillary Dysfunction and Tubular Injury (2007)

Acute kidney injury (AKI) remains a frequent and serious complication of human sepsis that contributes significantly to mortality. For better understanding of the development of AKI during sepsis, the cecal ligation and puncture (CLP) murine model of sepsis was studied using intravital video microscopy (IVVM) of the kidney. IVVM with FITC-dextran was used to determine the percentage of capillaries with continuous, intermittent or no flow at 0 (sham), 10, 16, and 22 h after CLP. There was a dramatic fall in capillary perfusion as early as 10 h after CLP that persisted through 22 h. The percentage of vessels with continuous flow at 16 h decreased from 73 +/- 2% in shams to 16 +/- 2% (P < 0.05), whereas the percentage of vessels with no flow increased from 4 +/- 1% in shams to 42 +/- 2% (P < 0.05). The capillary perfusion defect preceded the rise in serum creatinine. IVVM with dihydrorhodamine-123 was used to quantify in real time reactive nitrogen species (RNS) generation by renal tubules, and the inducible nitric oxide synthase inhibitor L-iminoethyl-lysine (mg/kg) was used to examine the role of inducible nitric oxide synthase inhibitor on capillary dysfunction and RNS generation. Tubular generation of RNS was significantly elevated at 10 h after CLP and was associated with tubules that were bordered by capillaries with reduced perfusion. L-iminoethyl-lysine significantly reversed the capillary perfusion defect, blocked RNS generation, and reduced AKI. These data show that capillary dysfunction and RNS generation contribute to tubular injury and suggest that RNS should be considered a potential therapeutic target in the treatment of sepsis-induced AKI.
Electrodeposition of Thin Magnetic Permalloy Films (1970)

A citrate‐complexed nickel‐iron electrolyte which has a long useful plating life from the point of view concerning the magnetic properties of the plated films and a better plating efficiency compared to the conventional baths has been used to plate thin magnetic films of 80:20 nickel‐iron from about 150 to about 8000Aå. The magnetic properties, like the coercive force and the anisotropy field , were determined at a known thickness as a function of current density, pH, temperature, and the concentration of citrate ion and the plating conditions optimized. The ferromagnetic domain patterns observed by the Bitter technique as a function of thickness show the same behavior as those observed in evaporated films. Internal stress measurements made as a function of thickness, current density, and temperature show that both the current density and the temperature have significant effect on stress. Photomicrographs of deposits obtained at a wide range of current density show the differences in the structure of the deposits.
An Aggregation Pheromone of the German Cockroach Blattella germanica L. (Orthoptera : Blattellidae) : I. Site of the Pheromone Production (1967)

Gregariousness has been found in the german cockroach, Blattella germanica L. Young nymphs of the german cockroach aggregate when they are resting. When newly hatched nymphs reared in solitary, the growth and development were delayed. The gregariousness is considered to be favourable for the existence of this insect. The facts that the aggregation was observed even in darkness and that the antennae played an important role for the aggregation suggest that chemical stimuli would be responsible. Active principle responsible for the aggregation was found both in the faeces and in ether washing of the body surface. Ether washing of the posterior portion of the abdomen showed higher activity than the other portions. These results indicate that the active principle would be produced either externaly or internaly in the region of the anus. As the result of histological studies, it was found that the epithelium of the rectum forms six rectal pads consisting of single layer of cells showing glandular nature. Filter papers conditioned with the german cokroaches whose abdominal tips had been amputated did not elicit the response for the aggregation, while those impregnated with methanol extract of the rectums dissected did. It is concluded that the active principle seems to be secreted from the rectal pad cells into the lumen of the rectum when faecal materials are passing, and then excreted with the faeces. The active principle found in the body surface was considered to be of the same origin as found in the faeces, and it adsorbed onto the body surface by its lipid nature. This active principle playing as an attractant for the aggregation seems to be a new kind of pheromone. We offer the term "aggregation pheromone" to this pheromone.
Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase δ (2020)

A macrocyclization approach has been explored on a series of benzoxazine phosphoinositide 3-kinase δ inhibitors, resulting in compounds with improved potency, permeability, and <i>in vivo</i> clearance while maintaining good solubility. The thermodynamics of binding was explored via surface plasmon resonance, and the binding of lead macrocycle <b>19</b> was found to be almost exclusively entropically driven compared with progenitor <b>18</b>, which demonstrated both enthalpic and entropic contributions. The pharmacokinetics of macrocycle <b>19</b> was also explored <i>in vivo</i>, where it showed reduced clearance when compared with the progenitor <b>18</b>. This work adds to the growing body of evidence that macrocyclization could provide an alternative and complementary approach to the design of small-molecule inhibitors, with the potential to deliver differentiated properties.
MinIE: Minimizing Facts in Open Information Extraction (2017)

The goal of Open Information Extraction (OIE) is to extract surface relations and their arguments from naturallanguage text in an unsupervised, domainindependent manner. In this paper, we propose MinIE, an OIE system that aims to provide useful, compact extractions with high precision and recall. MinIE approaches these goals by (1) representing information about polarity, modality, attribution, and quantities with semantic annotations instead of in the actual extraction, and (2) identifying and removing parts that are considered overly specific. We conducted an experimental study with several real-world datasets and found that MinIE achieves competitive or higher precision and recall than most prior systems, while at the same time producing shorter, semantically enriched extractions.
Differences in Intellectual Challenge of Writing Tasks among Higher and Lower Value-Added English Language Arts Teachers (2015)

Background Writing is an essential literacy skill; however, public school students often receive inadequate writing instruction, particularly as they move into middle and high school. However, research has shown that the nature of writing tasks assigned can impact writing development and student achievement measured by standardized assessments. With the need to assess teacher efficacy, districts are increasingly using some form of value-added modeling, although researchers warn of relying solely on value-added scores to distinguish between more and less effective teachers. Purpose This study investigated the intellectual challenge of typical writing tasks and the intellectual quality of student work in classrooms of higher and lower value-added middle school English language arts teachers to understand what value-added modeling might capture in terms of writing instruction. In particular, this article investigates how higher and lower value-added teachers differ in terms of (1) the intellectual challenge of typical tasks assigned, (2) the quality of supports surrounding the tasks, and (3) the quality of student work produced. Research Design Data for this study were collected as part of a larger study that identified pairs of middle school ELA teachers within the same school who were in their third through fifth years of teaching. Within each school, we identified at least one teacher in the fourth (top) quartile and one in the second (lower) quartile based on their measures of value-added to student achievement. We analyzed the typical and challenging writing tasks and corresponding student work for the intellectual quality, looking within and across the two groups of teachers to document patterns of instructional practices. Conclusions We found differences in the consistency of challenge and scaffolds between the two groups, with higher value-added teachers more consistently providing challenging and supportive tasks. Teachers whose typical writing tasks maintain a high degree of challenge are associated with higher student performance, as defined by a measure of teacher value-added. This implies the importance of educating teachers regarding the importance and nature of challenging assignments.
Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota (2011)

The gut microbiota is a signature of the metabolic phenotypes independent of differences in host genetic background and diet.
The Social Brain, Stress, and Psychopathology (2016)

Social discrimination can have pervasive effects on human health and performance. This notion is a major thread binding together findings in social psychology, health psychology, and epidemiology. From a psychiatric perspective, it may also be critical for a more complete etiological picture of psychopathology. Social influences can be subtle but powerful.
Mechanistic insights into enzymatic catalysis by trehalase from the insect gut endosymbiont Enterobacter cloacae (2019)

Energy metabolism in the diamondback moth Plutella xylostella is facilitated by trehalase, an enzyme which assists in trehalose hydrolysis, from the predominant gut bacterium Enterobacter cloacae . We report the biochemical and structural characterization of recombinant trehalase from E. cloacae (Px_EclTre). Px_EclTre showed K M of 1.47 (±0.05) m m , k cat of 6254.72 min −1 and V max 0.2 (±0.002) m m ·min −1 at 55 °C and acidic pH. Crystal structures of Px_EclTre were determined in the ligand‐free form and bound to the inhibitor Validoxylamine A. The crystal structure of the ligand‐free form, unavailable until now for any other bacterial trehalases, enabled us to delineate the conformational changes accompanying ligand binding in trehalases. Multiple salt bridges were identified that potentially facilitated closure of a hood over the substrate‐binding site. A cluster of five tryptophans lined the −1 substrate‐binding subsite, interacted with crucial active site residues and contributed to both trehalase activity and stability. The importance of these residues in enzyme activity was further validated by mutagenesis studies. Many of these identified residues form part of signature motifs and other conserved sequences in trehalases. The structure analysis thus led to the assignment of the functional role to these conserved residues. This information can be further explored for the design of effective inhibitors against trehalases.
MOVPE growth of quaternary (Al,Ga,In)N for UV optoelectronics[Metal Organic Vapor Phase Epitaxy, Ultraviolet] (2000)

The authors report the growth and characterization of quaternary AlGaInN. A comparison of photoluminescence (PL), high-resolution x-ray diffraction (XRD), and Rutherford backscattering spectrometry (RBS) characterizations enables one to explore the contours of constant-PL peak energy and lattice parameter as functions of the quaternary compositions. The observation of room temperature PL emission at 351 nm (with 20% Al and 5% In) renders initial evidence that the quaternary could be used to provide confinement for GaInN (and possibly GaN). AlGaInN/GaInN MQW heterostructures have been grown; both XRD and PL measurements suggest the possibility of incorporating this quaternary into optoelectronic devices.
Different Expression of Transforming Growth Factor β1 in Pancreatic Ductal Adenocarcinoma and Cystic Neoplasms (1997)

Pancreatic neoplasms harbor different prognoses according to their histological type: a benign course for serous cystadenoma, a low malignant potential for intraductal papillary mucinous neoplasms (IPMN), and high aggressiveness for ductal adenocarcinoma (ADC). Transforming growth factor beta 1 (TGF beta 1) may regulate tumor growth. The present study analyzes and compares the expression of its precursor beta 1-latency-associated peptide (beta 1-LAP), its latent binding protein (LTBP), and its mRNA in ductal adenocarcinoma (n = 10), in IPMN (n = 8), in serous cystadenoma (n = 2), and in normal tissues (n = 5). LTBP is thought to play a strategic role in the processing and active secretion of latent TGF beta 1 and its stockage in the extracellular matrix. Localization of beta 1-LAP and LTBP was assessed by immunohistochemistry using specific antibodies and expression of TGF beta 1 mRNA by reverse-transcriptase polymerase chain reaction analysis. beta 1-LAP was only slightly expressed in normal specimens, while LTBP was not detected. beta 1-LAP was detected in the cytoplasm of neoplastic cells in 9 of 10 patients with ADC. An intense staining was present in stromal cells surrounding the neoplastic glands in all cases except in one carcinoma in situ. LTBP was detected only in stromal cells and in the surrounding extracellular matrix. In IPMN with mild-grade dysplasia and in cystadenoma, beta 1-LAP was strongly expressed in the epithelial cells, while it was poorly detected in invasive IPMN; stromal cells were poorly or not all stained by beta 1-LAP, except in invasive IPMN (n = 2). LTBP was detected in neoplastic cells of three cases with benign IPMN and two of two cases with cystadenoma, while stroma was not immunostained. TGF beta 1 mRNA was strongly expressed in most of the tumors and no difference in expression was observed between the different types of neoplasms. There is no quantitative difference in expression of TGF beta 1 in ADC and in IPMN or cystadenoma. However, the latter are able to secrete TGF beta 1 efficiently, in contrast to ductal ADC as shown by the ability of the neoplastic cells to express both beta 1-LAP and LTBP. Invasive stroma reaction was associated with enhanced beta 1-LAP and LTBP expression in stromal cells and could be mediated by TGF beta 1 via LTBP
Baccalaureate nursing education curricula in the People’s Republic of China: Status, issues and reforms (2001)

This article examines baccalaureate nursing education curricula in the People's Republic of China. Three 5-year curricula and one 4-year curriculum were content analyzed and contrasted. Findings of this study suggested that: (i) the biomedical model dominated the three 5-year traditional curricula; (ii) political-ideological content permeated all four curricula; and (iii) the reformed curriculum at Peking Union Medical College was a genuine effort toward building a new nursing curriculum model that intended to differentiate nursing education from medical education. In addition, major themes of recent curriculum reforms were highlighted. Recommendations were suggested to improve the outcomes of future curriculum endeavors. Explicit as well as implicit comparisons with an ideal-typical American generic baccalaureate nursing curriculum were made when appropriate.
Activation of Dopamine D4 Receptors Is Protective Against Hypoxia/Reoxygenation-Induced Cell Death in HT22 Cells (2010)

Several reports have shown that some dopamine receptor ligands modulate the ischemia-reperfusion injury in animal models; however, its underling mechanisms are still unclear. In this study, we sought to establish an in vitro experimental model of hypoxia/reoxygenation (H/R) using HT22 cells that originated from mouse hippocampal neurons and to examine protective the effect of dopamine-receptor ligands against H/R-induced cell injury. The treatment with hypoxia for 18 h followed by reoxygenation for 6 h induced the elevation of intracellular reactive oxygen species (ROS) and reduction of mitochondrial membrane potential; however, lactate dehydrogenase (LDH) release was not changed at this time point. LDH release was increased after reoxygenation for 18 h and longer, and this increase in LDH release was suppressed by dopamine receptor agonists such as apomorphine and apocodeine. The suppressive effects of these agonists were reversibly inhibited by L750667, a D(4)-receptor antagonist but not by D(2)- or D(3)-receptor antagonists. In addition, PD168077, a selective dopamine D(4)-receptor agonist, also protected against H/R-induced cell death. These results suggest that H/R causes oxidative stress-induced cell death and that the activation of dopamine D(4) receptors protects against H/R-induced cell death in HT22 cells.
Superhydrophilic nanostructure (2023)

An embodiment of a superhydrophilic nanostructure includes nanoparticles. The nanoparticles are formed into porous clusters. The porous clusters are formed into aggregate clusters. An embodiment of an article of manufacture includes the superhydrophilic nanostructure on a substrate. An embodiment of a method of fabricating a superhydrophilic nanostructure includes applying a solution that includes nanoparticles to a substrate. The substrate is heated to form aggregate clusters of porous clusters of the nanoparticles.