gebhart/patrepeval huggingface dataset:
Superficial Mucoceles and Lichenoid Graft Versus Host Disease: Report of Three Cases (2002)

Superficial mucoceles are subepithelial extravasations of sialomucin that occur at the epithelial-connective tissue interface and are directly related to minor salivary glands. They have been described in association with oral lichen planus and, exceptionally, with chronic graft versus host disease. Three patients who underwent an allogeneic bone marrow transplantation for a chronic myelogenous leukaemia presented multiple superficial mucoceles and an oral lichenoid graft versus host disease.
Motion Estimation And Filtered Prediction For Dynamic Point Cloud Attribute Compression (2022)

In point cloud compression, exploiting temporal redundancy for inter predictive coding is challenging because of the irregular geometry. This paper proposes an efficient block-based inter-coding scheme for color attribute compression. The scheme includes integer-precision motion estimation and an adaptive graph based in-loop filtering scheme for improved attribute prediction. The proposed block-based motion estimation scheme consists of an initial motion search that exploits geometric and color attributes, followed by a motion refinement that only minimizes color prediction error. To further improve color prediction, we propose a vertex-domain low-pass graph filtering scheme that can adaptively remove noise from predictors computed from motion estimation with different accuracy. Our experiments demonstrate significant coding gain over state-of-the-art coding methods.
A Smart Metering System Architecture Based on Radio over Fiber Technology (2013)

In this paper, we propose to use radio over fiber (RoF) technology in smart metering systems which can make full use of the fiber resources laid by power companies and expand the coverage through wireless signal. In the demo experiments, a RoF-based smart metering system with commercial smart meter and developed software is successfully demonstrated.
Human urine-derived renal epithelial cells provide insights into kidney-specific alternate splicing variants (2018)

The majority of multi-exon genes undergo alternative splicing to produce different mRNA transcripts and this may occur in a tissue-specific manner. Assessment of mRNA transcripts isolated from blood samples may sometimes be unhelpful in determining the affect on function of putative splice-site variants affecting kidney-specific mRNA transcripts. Here we present data demonstrating the power of using human urine-derived renal epithelial cells (hUREC) as a source of kidney RNA. We report clinical and molecular genetic data from three affected cases from two families all with end-stage renal disease by 15 years of age. In both families, heterozygous variants which are predicted to effect function in NPHP3 were found on one allele, in combination with a synonymous SNV (c.2154C>T; p.Phe718=), 18 base pairs from the exon-intron boundary within exon 15 of NPHP3. The only mRNA transcript amplified from wild-type whole blood showed complete splicing out of exon 15. Urine samples obtained from control subjects and the father of family 2, who carried the synonymous SNV variant, were therefore used to culture hUREC and allowed us to obtain kidney-specific mRNA. Control kidney mRNA showed retention of exon 15, while the mRNA from the patient's father confirmed evidence of a heterozygous alternate splicing of exon 15 of NPHP3. Analysis of RNA derived from hUREC allows for a comparison of kidney-specific and whole-blood RNA transcripts and for assessment of the effect on function of putative splice variants leading to end-stage kidney disease.
Electrostatic Model Applied to ISS Charged Water Droplet Experiment (2015)

The electrostatic force can be used to create novel relative motion between charged bodies if it can be isolated from the stronger gravitational and dissipative forces. Recently, Coulomb orbital motion was demonstrated on the International Space Station by releasing charged water droplets in the vicinity of a charged knitting needle. In this investigation, the Multi-Sphere Method, an electrostatic model developed to study active spacecraft position control by Coulomb charging, is used to simulate the complex orbital motion of the droplets. When atmospheric drag is introduced, the simulated motion closely mimics that seen in the video footage of the experiment. The electrostatic force's inverse dependency on separation distance near the center of the needle lends itself to analytic predictions of the radial motion.
A New Indole Alkaloid Glycoside from the Leaves ofPalicourea marcgravii (1989)

A new indole alkaloid glucoside, named palicoside, has been isolated from the leaves of PALICOUREA MARCGRAVII (Rubiaceae) collected in Brazil. The structure was established by spectroscopic methods and its chemical conversion to strictosamide.
60 GHz-band ultra-miniature monolithic T/R modules for multimedia wireless communication systems (2002)

60 GHz-band ultra-miniature FM/FSK transmitter/receiver modules utilizing a complete MMIC chip set including dielectrically stabilized VCO and local oscillator for wireless LANs and video signal transmission systems are reported. The 0.9 cc transmitter module exhibits 11.5 MHz/V modulation sensitivity and 10.2 dBm output power with -2.8 ppm//spl deg/C frequency stability. The receiver module has 9.2 dB downconversion gain and 5.4 dB DSB noise figure.
[Screening for diabetic retinopathy: non-mydriatic retinal photography]. (2003)

The screening of diabetic retinopathy is still largely insufficient and consequently, its management is often delayed. The various recommendations indicate a fundus examination at diabetes diagnosis and yearly thereafter. In France, this is far to be reached, and this situation is at risk of aggravation with the increasing number of diabetic patients and the decreasing number of ophthalmologists. New efficient tools, as the non-mydriatic cameras and digital photography, may allow a new network organisation for screening of diabetic retinopathy, with local screening sites linked to a centralised ophthalmological reading center where digital images could be transmitted. The various aspects of this screening and possibilities to improve the screening and early management of diabetic retinopathy are discussed in this paper.
Reducing the Sodium Intake of Patients With Chronic Kidney Disease Through Education and Estimating Salt Excretion: A Propensity Score Matching Analysis (2023)

A simple salt reduction education may reduce salt intake in outpatients with CKD.
Designing a Multi-Agent Portfolio Management System (1996)

The voluminous and readily available information on the Internet has given rise to exploration of Intelligent Agent technology for accessing, filtering, evaluating and integrating information. In contrast to most current research that has investigated single-agent approaches, we are developing a collection of multiple agents that team up on demand, depending on the user, the task and the situation, to access, filter and integrate information in support of user tasks. We are investigating techniques for developing distributed adaptive collections of information agents that coordinate to retrieve, filter and fuse information relevant to the user, task and situation, as well as anticipate user’s information needs. Our approach is based on (1) case-based task and situation models, (2)flexible organizational structuring, and (3) reusable agent architecture. We are currently implementing the system in the domain of financial portfolio management. While this paper focuses on the big picture, the final section will describe the current implementation and point to our work on detailed technical solutions.
Security aspects of e-Health systems migration to the cloud (2014)

As adoption of e-health solutions advances, new computing paradigms - such as cloud computing - bring the potential to improve efficiency in managing medical health records and help reduce costs. However, these opportunities introduce new security risks which can not be ignored. Based on our experience with deploying part of the Swedish electronic health records management system in an infrastructure cloud, we make an overview of major requirements that must be considered when migrating e-health systems to the cloud. Furthermore, we describe in-depth a new attack vector inherent to cloud deployments and present a novel data confidentiality and integrity protection mechanism for infrastructure clouds. This contribution aims to encourage exchange of best practices and lessons learned in migrating public e-health systems to the cloud.
Novel Fractal Feature-Based Multiclass Glaucoma Detection and Progression Prediction (2012)

We investigate the use of fractal analysis (FA) as the basis of a system for multiclass prediction of the progression of glaucoma. FA is applied to pseudo two-dimensional images converted from one-dimensional retinal nerve fiber layer (RNFL) data obtained from the eyes of normal subjects, and from subjects with progressive and non-progressive glaucoma. FA features are obtained using a box-counting method and a multi-fractional Brownian motion method that incorporates texture and multiresolution analyses. Both features are used for Gaussian kernel-based multiclass classification. Sensitivity, specificity, and area under receiver operating characteristic curve (AUROC) are computed for the FA features and for metrics obtained using wavelet-Fourier analysis (WFA) and fast-Fourier analysis (FFA). The AUROCs that predict progressors from non-progressors based on classifiers trained using a dataset comprised of non-progressors and ocular normal subjects are 0.70, 0.71 and 0.82 for WFA, FFA, and FA, respectively. The correct multiclass classification rates among progressors, non-progressors, and ocular normal subjects are 0.82, 0.86 and 0.88 for WFA, FFA, and FA, respectively. Simultaneous multiclass classification among progressors, non-progressors, and ocular normal subjects has not been previously described. The novel FA-based features achieve better performance with fewer features and less computational complexity than WFA and FFA.
Hyperbranched Polymer–Gold Nanoparticle Assemblies: Role of Polymer Architecture in Hybrid Assembly Formation and SERS Activity (2014)

Plasmonic gold nanoassemblies that self-assemble with the aid of linking molecules or polymers have the potential to yield controlled hierarchies of morphologies and consequently result in materials with tailored optical (e.g., localized surface plasmon resonances (LSPR)) and spectroscopic properties (e.g., surface-enhanced Raman scattering (SERS)). Molecular linkers that are structurally well-defined are promising for forming hybrid nanoassemblies which are stable in aqueous solution and are increasingly finding application in nanomedicine. Despite much ongoing research in this field, the precise role of molecular linkers in governing the morphology and properties of the hybrid nanoassemblies remains unclear. Previously we have demonstrated that branched linkers, such as hyperbranched polymers, with specific anchoring end groups can be successfully employed to form assemblies of gold NPs demonstrating near-infrared SPRs and intense SERS scattering. We herein introduce a tailored polymer as a versatile molecular linker, capable of manipulating nanoassembly morphologies and hot-spot density. In addition, this report explores the role of the polymeric linker architecture, specifically the degree of branching of the tailored polymer in determining the formation, morphology, and properties of the hybrid nanoassemblies. The degree of branching of the linker polymer, in addition to the concentration and number of anchoring groups, is observed to strongly influence the self-assembly process. The assembly morphology shifts primarily from 1D-like chains to 2D plates and finally to 3D-like globular structures, with increase in degree of branching of the macromolecular linker. Insights have been gained into how the morphology influences the SERS performance of these nanoassemblies with respect to hot-spot density. These findings supplement the understanding of the morphology determining nanoassembly formation and pave the way for the possible application of these nanoassemblies as SERS biosensors for medical diagnostics.
Proline Benzyl Ester as Chiral Auxiliary in Barbier-Type Reactions in Aqueous Solution (1990)

α-Keto amides of proline benzyl ester [N-(α-oxoacyl)prolines] react with allyl halides in the presence of zinc in an asymmetric Barbier-type carbonyl-addition reaction to give the corresponding α-hydroxy amides in high yields and with good diastereoselectivities.
Inflammasome, IL-1 and inflammation in ozone-induced lung injury. (2016)

Exposure to ambient ozone causes airway hyperreactivity and lung inflammation, which represent an important health concern in humans. Recent clinical and experimental studies contributed to the understanding of the mechanisms of epithelial injury, inflammation and airway hyperreactivity, which is reviewed here. The present data suggest that ozone induced oxidative stress causes inflammasome activation with the release of IL-1, other cytokines and proteases driving lung inflammation leading to the destruction of alveolar epithelia with emphysema and respiratory failure. Insights in the pathogenic pathway may allow to identify novel biomarkers of ozone-induced lung disease and therapeutic targets.
Pseudo Random Signal Processing: Theory and Application (2005)

In recent years, pseudo random signal processing has proven to be a critical enabler of modern communication, information, security and measurement systems. The signal's pseudo random, noise-like properties make it vitally important as a tool for protecting against interference, alleviating multipath propagation and allowing the potential of sharing bandwidth with other users. Taking a practical approach to the topic, this text provides a comprehensive and systematic guide to understanding and using pseudo random signals. Covering theoretical principles, design methodologies and applications
Nickel requirement for active hydrogenase formation in Alcaligenes eutrophus (1981)

The nickel-dependent chemolithoautotrophic growth of Alcaligenes eutrophus is apparently due to a requirement of nickel for active hydrogenase formation. Cells grown heterotrophically with fructose and glycerol revealed a specific activity of soluble and membrane-bound hydrogenase which was severalfold higher than the normal autotrophic level. The omission of nickel from the medium did not affect heterotrophic growth, but the soluble hydrogenase activity was reduced significantly. In the presence of ethylenediaminetetraacetic acid (EDTA), almost no hydrogenase activity was detected. The addition of nickel allowed active hydrogenase formation even when EDTA was present. When chloramphenicol was added simultaneously with nickel to an EDTA-containing medium, almost no hydrogenase activity was found. This indicates that nickel ions are involved in a process which requires protein synthesis and not the direct reactivation of a preformed inactive protein. The formation of the membrane-bound hydrogenase also appeared to be nickel dependent. Autotrophic CO2 assimilation did not specifically require nickel ions, since formate was utilized in the presence of EDTA and the activity of ribulosebisphosphate carboxylase was not affected under these conditions.
Performance of novel sorghum germplasm in Pennsylvania and their response to anthracnose (2021)

Abstract Sorghum ( Sorghum bicolor L.) has the potential to become a widespread commercial feedstock crop in Pennsylvania, either in rotation with maize ( Zea mays L.) or grown alongside it. In other locations where sorghum has been grown for a long time, it is attacked by Colletotrichum sublineola Henn. ex Sacc. &amp; Trotter, a fungal pathogen that causes anthracnose ( Colletotrichum sublineola ) leaf blight (ALB), thereby diminishing yield. Field surveys were carried out in 2011, 2012, and 2016 to monitor the presence of C . sublineola in commercial sorghum fields in six Pennsylvania locations. Senescing, lower leaves developed lesions that yielded Colletotrichum sp., including isolates of C . sublineola . The pathogen was not recovered from field debris, and ALB symptoms were not observed on the younger leaves of plants. In preparation for widespread cultivation of sorghum in Pennsylvania, we evaluated the performance, in field and greenhouse tests, of 158 experimental lines and commercial hybrids, which had been improved in several states in the United States and in other parts of the world. Sources of resistance to ALB and other foliar diseases were discovered that should be useful in breeding programs targeted for Pennsylvania and for northeastern U.S. climatic conditions. Lines received from ICRISAT, especially ICSB94, showed the highest level of resistance in the field.
Internal Structure of a Seafloor Massive Sulfide Deposit by Electrical Resistivity Tomography, Okinawa Trough (2019)

Abstract Although seafloor massive sulfide (SMS) deposits are crucially important metal resources that contain high‐grade metals such as copper, lead, and zinc, their internal structures and generation mechanisms remain unclear. This study obtained detailed near‐seafloor images of electrical resistivity in a hydrothermal field off Okinawa, southwestern Japan, using deep‐towed marine electrical resistivity tomography. The image clarified a semi‐layered resistivity structure, interpreted as SMS deposits exposed on the seafloor, and another deep‐seated SMS layer at about 40‐m depth below the seafloor. The images reinforce our inference of a new mechanism of SMS evolution: Upwelling hydrothermal fluid is trapped under less‐permeable cap rock. The deeper embedded SMS accumulates there. Then hydrothermal fluids expelled on the seafloor form exposed SMS deposits.
A comparative study on two radioimmunoassays with cloned human interferon-alpha. (1983)

We report here on the development of (a) a double-antibody radioimmunoassay and (b) a solid-phase radioimmunoassay for cloned human interferon-alpha (leukocyte) [HuIFN-alpha(Le)]. We present the results of titrations of human interferon-alpha-2 (HuIFN-alpha 2) using either method under experimental and optimized conditions. A comparative study of the two methods indicates that (a) the double-antibody procedure is 200-fold more economical of antibody when quantitations are carried out within an optimal range of 0.05--1.0 ng; (b) the double-antibody method is fivefold more sensitive than the solid-phase method, its sensitivity being within the range of the antiviral assays for interferons; and (c) the solid-phase assay is significantly faster. The data also support the presence in human serum of a factor(s) that decreases the maximal amount of HuIFN-alpha 2 bound to antibody. We conclude that these radioimmunoassays are superior to biological assays for the quantitation of interferon-alpha polypeptides from the standpoints of objectivity and reproducibility as well as time and effort required.
Resilience in the Face of Pandemic: The Impact of COVID-19 on the Psychologic Morbidity and Health-Related Quality of Life Among Women With Ovarian Cancer (2022)

Despite the far-reaching impact of the COVID-19 pandemic, ovarian cancer survivors' HRQOL has been maintained. Older age, high resilience, high mental health, and being off chemotherapy predicted better HRQOL. Ovarian cancer survivors remain resilient in the face of the pandemic, and the support of clinicians to preserve this invaluable personal resource is critical for well-being.
Peptide-Nucleoside Conjugates: Synthesis and Anti-HIV Activities (1995)

Abstract New peptide-nucleosides which consist of an anti-RT nucleoside and anti-protease peptide moieties, were designed in order to investigate their anti-HIV-1 properties. The synthesis of these new analogues was achieved using BOP coupling reagent which avoided the protection and deprotection steps of the 5′-OH group of the nucleoside part. These new compounds tested on MT4 infected cells show no increase in anti-HIV activities compared to that of the component pieces. Interestingly we found that the 5′-(tert-butyldiphenyl)silyl analogues show anti-HIV activities equivalent to that of the 5′-free OH corresponding compounds. This result suggests a possible interaction of these compounds at a non-substrate binding site of the reverse transcriptase.
Synthesis of fluorinated α‐amino ketones, III. Preparation of fluorinated ketone analogues of phenylalanine, lysine, and p‐(Guanidino)phenylalanine (1990)

Abstract The synthesis of α‐amino mono‐, di‐, and trifluoromethyl and difluoromethylene ketones and their derivatives is described. A one‐pot sequence related to the Dakin‐West reaction starts from amino acids and gives the corresponding fluorinated ketone analogues in good yields. The compounds are of interest as potential inhibitors of serine proteases.
Formation of Two Diverse Classes of Poly(amino-alkoxide) Chelates and Their Mononuclear and Polynuclear Lanthanide(III) Complexes (2003)

Factors that influence aggregation of lanthanide(III) (Ln(III)) ions to form polynuclear complexes were studied utilizing 1-aziridineethanol as a versatile source of macrocyclic and acyclic chelates. The facile ring-opening cyclo-oligomerization of 1-aziridineethanol leads to the formation of a series of polyaza cyclic oligomers (series A). In the presence of ethylenediamine, a competing N-alkylation reaction occurs to produce a new class of acyclic ligands (series B). The cyclo-oligomerization of four 1-aziridineethanol units is the most favorable process, leading to the formation of the 12-membered cyclen-type macrocycle, H(4)L(1) (1,4,7,10-tetrakis(2-hydroxyethyl)-1,4,7,10-tetraaza-cyclododecane). Ring-opening cyclo-oligomerization of 1-aziridineethanol in the presence of Ln(III) ions produces self-assembled mononuclear, tetranuclear, and pentanuclear compounds of H(4)L(1). In the presence of ethylenediamine, oligomerization of 1-aziridineethanol results in a dinuclear complex of an acyclic poly(amino-alkoxide) H(2)L(2). The coordinative unsaturation of (i) the alkoxy sites of [H(x)L(1)](x)(-)(4) (where x < 4) and (ii) Ln(III) ions in coordination numbers less than nine are critical factors in the formation of the polynuclear Ln(III) complexes. The identities of mononuclear, dinuclear, tetranuclear, and pentanuclear complexes herein discussed were established by X-ray crystallography.
Sum Capacity Maximization in Multi-Hop Mobile Networks with Flying Base Stations (2022)

Deployment of multi-hop network of unmanned aerial vehicles (UAVs) acting as flying base stations (FlyBSs) presents a remarkable potential to effectively enhance the performance of wireless networks. Such potential enhancement, however, relies on an efficient positioning of the FlyBSs as well as a management of resources. In this paper, we study the problem of sum capacity maximization in an extended model for mobile networks where multiple FlyBSs are deployed between the ground base station and the users. Due to an inclusion of multiple hops, the existing solutions for two-hop networks cannot be applied due to the incurred backhaul constraints for each hop. To this end, we propose an analytical approach based on an alternating optimization of the FlyBSs' 3D positions as well as the association of the users to the FlyBSs over time. The proposed optimization is provided under practical constraints on the FlyBS's flying speed and altitude as well as the constraints on the achievable capacity at the backhaul link. The proposed solution is of a low complexity and extends the sum capacity by 23%-38% comparing to state-of-the-art solutions.