gebhart/patrepeval huggingface dataset:
DAAM2 Polymorphism and Allogeneic Hematopoietic Stem Cell Transplantation. (2007)

Abstract Background WNT signaling pathway is known to have important functions in embryogenesis, cellular proliferation and regeneration, stem cell renewal and oncogenesis. DAAM2 is one of the key protein of WNT/PCP signaling pathway. This study examines the association of DAAM2 polymorphism and the clinical outcomes in patients treated with allogeneic hematopoietic stem cell transplantation (HSCT). Objectives and methods Candidate SNPs associated with acute graft versus host disease (GVHD) were selected using DNA chip analysis with Illumina Infinium Human-1 microarrays™ in 15 patients who treated with allogeneic HSCT for various hematologic and oncologic diseases with or without acute GVHD. Six SNPs (rs2504787, rs2504086, rs2504082, rs3004067, rs882559, and rs3004070) on DAAM2 were proven to be associated with acute GVHD, and extended genotyping was executed by Taqman™ protocol in more large population of 239 patients in single institute. Retrospective analysis for medical records was performed to define correlation of these SNPs with clinical outcomes of the patients. Results rs882559 located upstream from exon 24, was proven to be associated with acute GVHD incidence. Acute GVHD incidence was significantly lower in the patients with CC genotype of rs882559 than those with CG or GG genotype (HR 0.466, 95% CI 0.224∼0.969, p=0.0409). The allele frequency of C was 55% and that of G 44%. The genotyping disclosed CC in 77, CG in 110, and GG in 52. Multivariate analyses on various parameters including sex, age, transplant method (reduced intensity conditioning vs. conventional conditioning), stem cell source, risk group, and DAAM2 genotypes, as parameters, identified high-risk group defined in our previous study (KH Lee et al., Haematologica, 2007;92 ; HR 2.41, 95% CI 1.47∼3.94, p&lt;0.001), age over 50 years (HR 1.70, 95% CI 1.18∼2.45, p=0.004) and codominant genotype of rs2504082, i.e., an intron mutation upsteam from exon 15 (HR 1.326, 95% CI 1.02∼1073, p=0.0378) as risk factors for a shorter survival. Interpretation and conclusions This is the first clinical study for the DAAM2 polymorphism, furthermore, and its association with clinical outcomes of allogeneic HSCT. The role of rs882559 and rs2504082 were not identified by now, but its mutation might affect to the transcription of following coding genes causing the changes of its functions. This study suggested the clinical value of DAAM2 polymorphism as a predictive parameter of clinical outcomes of allogeneic HSCT, and its importance in WNT signaling pathway.
Proteaseinhibitoren in der Therapie der chronischen Hepatitis C (2007)

Reesink HW, Zeuzem S, Weegink CJ, Forestier N, van Vliet A, van de Wetering de Rooij J, McNair L, Purdy S, Kauffman R, Alam J, Jansen PLM. Rapid Decline of Viral RNA in Hepatitiis C Patients Treated With VX-950: A Phase Ib, Placebo-Controlled, Randomized Study. Gastroenterology 2006; 131: 997 - 1002
Taurine and platelet aggregation (1986)

Taurine is a putative neurotransmitter or neuromodulator. The endogenous taurine concentration in human platelets, determined by amino acid analysis, is 15 ..mu..M/g. In spite of this high level, taurine is actively accumulated. Uptake is saturable, Na/sup +/ and temperature dependent, and suppressed by metabolic inhibitors, structural analogues, and several classes of centrally active substances. High, medium and low affinity transport processes have been characterized, and the platelet may represent a model system for taurine transport in the CNS. When platelets were incubated with /sup 14/C-taurine for 30 minutes, then resuspended in fresh medium and reincubated for one hour, essentially all of the taurine was retained within the cells. Taurine, at concentrations ranging from 10-1000 ..mu..M, had no effect on platelet aggregation induced by ADP or epinephrine. However, taurine may have a role in platelet aggregation since 35-39% of the taurine taken up by human platelets appears to be secreted during the release reaction induced by low concentrations of either epinephrine or ADP, respectively. This release phenomenon would imply that part of the taurine taken up is stored directly in the dense bodies of the platelet.
Pain coping behaviour strategies in people with haemophilia: A systematic literature review (2022)

Literature on pain coping behaviour strategies and associated factors in PwH is still scarce and describes heterogenous results. Validated haemophilia-specific instruments are warranted to inventory pain coping behaviour in a standardized way.
Abstract IA26: Liquid biopsy in precision pathology: Plasma and beyond! (2020)

Abstract Launched in 2006, The Cancer Genome Atlas project (TCGA) aimed at systematically exploring the entire spectrum of genomic changes involved in human cancer. This year, the colossal effort culminated with the analysis of 11,000 cases across 33 tumor types. The comprehensive multiparametric (i.e., genomic, transcriptomic, epigenomic, and proteomic) analysis has yielded staggering datasets characterizing the molecular underpinning of human cancer types. This resulted in robust molecular classifications for common malignancies. A shared functional categorization of molecular alterations across tumor types has emerged, which offers a multitude of druggable targets. As the list of actionable genetic alterations in solid and hematologic malignancies continue to grow, molecular diagnostic applications are rapidly penetrating the daily practice of the pathologist in an unparalleled pace. “Precision pathology” is now an integral part of the practice of “precision oncology.” Despite initial response, patients receiving targeted therapy will develop resistance due to clonal evolution and the acquired survival advantage of nonresponsive tumor clones. As a result, treated patients are increasingly subjected to longitudinal surveillance for clonal evolution in search of new targets. The need for repeated tumor sampling for surveillance is driving the search for dynamic noninvasive tumor sampling methods. Non-tissue-based sampling methods (liquid biopsy) offer easy repeated access to tumor material in cancer patient body fluids for genomic analysis. Compared to traditional tissue biopsies, liquid biopsies also offer the advantage of “global” analysis of the often heterogeneous tumor genomic landscape both within primary and metastatic sites. The promise of liquid biopsy assays has fueled billions of dollars of investment from major biotechnology players. The current seminar will discuss the principles of liquid biopsy technology. Challenges facing the applications of plasma and urine-based liquid biopsy techniques in precision pathology will be highlighted. Citation Format: George J. Netto. Liquid biopsy in precision pathology: Plasma and beyond! [abstract]. In: Proceedings of the AACR Special Conference on Advances in Liquid Biopsies; Jan 13-16, 2020; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(11_Suppl):Abstract nr IA26.
Standardization and quality management in next-generation sequencing (2016)

DNA sequencing continues to evolve quickly even after > 30 years. Many new platforms suddenly appeared and former established systems have vanished in almost the same manner. Since establishment of next-generation sequencing devices, this progress gains momentum due to the continually growing demand for higher throughput, lower costs and better quality of data. In consequence of this rapid development, standardized procedures and data formats as well as comprehensive quality management considerations are still scarce. Here, we listed and summarized current standardization efforts and quality management initiatives from companies, organizations and societies in form of published studies and ongoing projects. These comprise on the one hand quality documentation issues like technical notes, accreditation checklists and guidelines for validation of sequencing workflows. On the other hand, general standard proposals and quality metrics are developed and applied to the sequencing workflow steps with the main focus on upstream processes. Finally, certain standard developments for downstream pipeline data handling, processing and storage are discussed in brief. These standardization approaches represent a first basis for continuing work in order to prospectively implement next-generation sequencing in important areas such as clinical diagnostics, where reliable results and fast processing is crucial. Additionally, these efforts will exert a decisive influence on traceability and reproducibility of sequence data.
Prostate cancer screening in the Prostate, Lung, Colorectal and Ovarian cancer screening trial: update on findings from the initial four rounds of screening in a randomized trial (2008)

The present findings on serial prostate screening are similar to those reported from other multi-round screening studies. Determining the effect of PSA screening on prostate cancer mortality awaits further follow-up.
Broadband EUV/FUV mirror coatings for a solar spectrograph mission (2018)

As it is rich in spectral lines emitted by plasma between 10000 K and 20 MK, the vacuum ultraviolet (VUV - 17 to 200 nm) solar spectrum is extremely valuable for instruments that study the physics of the solar atmosphere. We present multilayer coatings with simultaneous broadband reflectance in the two spectral ranges of 16.9 nm to 21.5 nm and 46.3 nm to 127.5 nm. The coatings are based on Mo/Si multilayers with a thin capping layer of boron carbide (B<sub>4</sub>C). Samples were produced and their reflectance measured. Their performance in terms of resistance to high temperatures and low micro-roughness was also assessed by measurement. Our study shows that a coating with the characteristics required by next generation spectrometers for studies of the solar atmosphere is feasible.
Significance Test in Speaker Recognition Data Analysis with Data Dependency (2012)

To evaluate the performance of speaker recognition systems, a detection cost function defined as a weighted sum of the probabilities of type I and type II errors is employed. The speaker datasets may have data dependency due to multiple uses of the same subjects. Using the standard errors of the detection cost function computed by means of the two-layer nonparametric two-sample bootstrap method, a significance test is performed to determine whether the difference between the measured performance levels of two speaker recognition algorithms is statistically significant. While conducting the significance test, the correlation coefficient between two detection cost functions for two algorithms, respectively, is taken into account. Examples are provided.
Transceiver Design for Spectrum Sharing Between FD Cellular System and MIMO Radar (2018)

We consider the spectral coexistence between collocated multiple-input-multiple-output (MIMO) radar and a full-duplex (FD) MIMO cellular system. Considering imperfect channel state information and hardware impairments at the cellular base station (BS), we focus on the design of beamforming matrices at the cellular system via the minimization of sum mean-squared-errors such that the detection probability of the radar is not affected due to spectrum sharing. The formulated problem is non-convex and hence we convert it into an equivalent semidefinite programming problem and propose an iterative algorithm to find the optimal beamforming matrices. Numerical results verify the eminence of spectrum sharing, albeit certain tradeoffs. In particular, using the spectrum shared by the radar, the FD cellular system can achieve an area throughput of around 4-5 Mbps/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a reasonable self-interference cancellation of around -70 dB. However, to facilitate this, while also maintaining a detection probability of around 0.9, the MIMO radar needs to spend an extra power of around 3-4 dB.
Quantitative Analysis of Vapor Formation Process in Gasoline Spray in Evaporation Field with Laser Induced Exciplex Fluorescence Method (LIEF Method) (2021)

本報では，非定常蒸発ガソリン噴霧を対象にエキサイプレックス蛍光法を用いた気液相二相の領域における蒸気形成過程の実験的な解析を報告する．本研究では，混合気の平均温度を用いて気液相二相領域の蒸気濃度を算出する画像処理法を開発した．本手法は，気相と液相間の蛍光の混信を考慮したものであり，これを蒸発過程にあるガソリン噴霧に適用した．その結果，噴霧の内部と外縁では異なる蒸発過程をとることがわかった．
Flow and sediment transport in compound channels : the experiences of Japanese and UK research (2009)

ch. 1. Introduction -- ch. 2. Flow structure -- ch. 3. Sediment processes -- ch. 4. Computer simulation -- ch. 5. Design considerations -- ch. 6. Conclusions and recommendations.
Color image appearance model applied to printing of watermarked images (2004)

Several authors have proposed the application of perceptual models to the watermarking of still images. Most of these methods use a luminance based model and do not take into account the effect of the output process on image quality. For example, in printing, the same digital image appears very different when printed on newsprint, compared to printing on high quality gloss paper. The color image appearance model we described has been used to obtain approximately equal watermark visibility across an image. For a given visibility, this allows a higher watermark signal to be applied to an image. The watermark signal strength has also been corrected for images output on different types of paper stock, to obtain approximately the same visibility level.
Flip chip joining with low temperature solders and thermal gradient bonding (2017)

In this study, we investigated effects of thermal gradient of joint during flip chip bonding on intermetallic compound (IMC) growth for several solder materials. Cu/Sn-2.5Ag/Cu joint was prepared by bonding electroplated Cu/Sn-2.5Ag bump on Cu pad. Ni/Sn/Ni, Ni/In/Ni, Ni/In-48Sn/Ni, and Ni/Sn-58Bi/Ni joints were prepared by solder capping by IMS on electro-less plated Ni/Au post and bonding it on electro-less plated Ni/Au pad. Joint pitch and diameter were 80 micron and 38 micron respectively. Joints prepared by thermal gradient bonding (TGB) were compared with those by homogeneous temperature bonding (HTB). With Cu/Sn-2.5Ag/Cu joints, firstly we confirmed faster growth of IMCs at a cold end than a hot end of the joint and thicker IMC in the TGB joint than in the HTB joint. These important features of TGB were also confirmed experimentally on joints with low temperature solder materials. It indicates that TGB can be used for the joints with low temperature solders to shorten bonding time for full IMC joint. IMC growth at the cold end of Ni/In/Ni joint prepared by TGB was as fast as that of Ni/Sn/Ni joint by HTB.
L-Arginine and Superoxide Dismutase Prevent or Reverse Cerebral Hypoperfusion after Fluid-Percussion Traumatic Brain Injury (1997)

To determine whether treatment with L-arginine or superoxide dismutase (SOD) would prove effective in reducing cerebral hypoperfusion after traumatic brain injury (TBI), we measured cerebral blood flow (CBF) using laser Doppler flowmetry (LDF) in rats treated before or after moderate (2.2 atm) fluid-percussion (FP) TBI. Rats were anesthetized with isoflurane and prepared for midline FP TBI and then for LDF by thinning the calvaria using an air-cooled drill. Rats were then randomly assigned to receive sham injury, sham injury plus L-arginine (100 mg/kg, 5 min after sham TBI), TBI plus 0.9% NaCl, TBI plus L-arginine (100 mg/kg, 5 min post-TBI), TBI plus SOD (24,000 U/kg pre-TBI + 1600 units/kg/min for 15 min after TBI), or TBI plus SOD and L-arginine. A second group of rats received TBI plus saline, L-, or D-arginine (100 mg/kg, 5 min after-TBI). After treatment and TBI or sham injury, CBF was measured continuously using LDF for 2 h and CBF was expressed as a percent of the preinjury baseline for 2 h after TBI. Rats treated with saline or D-arginine exhibited significant reductions in CBF that persisted throughout the monitoring period. Rats treated with L-arginine alone or in combination with SOD exhibited no decreases in CBF after TBI. CBF in the SOD-treated group decreased significantly within 15 min after TBI but returned to baseline levels by 45 min after TBI. These studies indicate that L-arginine but not D-arginine administered after TBI prevents posttraumatic hypoperfusion and that pretreatment with SOD will restore CBF after a brief period of hypoperfusion.
A study of array pattern tuning method using hybrid genetic algorithms for figure-8 satellite's earth station antenna (2002)

An array pattern tuning method of the fixed earth station's antenna for figure-8 satellite was described. The conditions of the array antenna's design are to track the figure-8 satellite and direct nulls to multiple geostationary satellites in order to share the same frequency between figure-8 satellite and geostationary satellites. To determine optimal excitation coefficients of the array antenna, Hybrid Genetic Algorithms (Hybrid GA) which is the combination of Genetic Algorithm (GA) and descent method were applied. Simulations were performed for the phased array antenna, which had 4 by 4 element antennas and 4-bit phase shifters. For 9 of 11 directions of figure-8 satellite, hybrid GA found the designed antenna pattern.
Aerosolized Albuterol Sulfate Delivery under Neonatal Ventilatory Conditions: In Vitro Evaluation of a Novel Ventilator Circuit Patient Interface Connector (2013)

The use of the VC connector increased the delivery of albuterol sulfate and resulted in a PSD profile at the patient interface that is more consistent with the PSD profile of the selected nebulizer when compared with SoC. This VC connector may be a useful, new approach for the delivery of aerosolized medications to neonates requiring positive pressure ventilatory support.
A TRANSIENT RESPONSE ANALYSIS OF A VERY LARGE FLOATING STRUCTURE BY FINITE ELEMENT METHOD (1998)

本研究は, 航空機着陸荷重による超大型浮体式構造物の過渡応答解析を有限要素法により行ったものである. 不規則波に対して開境界条件を適用するため, スポンジ層と Sommerfeld 境界を組み合わせた波浪吸収フイルターを適用し, その有効性を確認した. また, 航空機着陸を模擬した荷重による浮体の応答特性は, 着陸から数秒間は軸対称形状となるが, それ以後は浮体の形状の影響を大きく受け, 非軸対称形状となる事を示した.
Synergistic interaction between PPAR ligands and salbutamol on human bronchial smooth muscle cell proliferation (2012)

The synergistic interaction between PPARγ agonists and β(2) -adrenoceptor agonists on airway smooth muscle cell proliferation highlights the anti-remodelling potential of this combination in chronic lung diseases.
Architecting a Communication Satellite Product Line (2004)

Current unfavorable market conditions have shifted the preference of commercial communication satellite operators from large spacecraft systems with high bandwidth capacities, to small and medium size spacecraft. However, most satellite manufacturers have not caught up yet with this trend and are still positioned as providers of large capacity satellite systems. This paper investigates the application of product family concepts to the design of commercial satellites in an effort to formulate an approach that allows a manufacturer to develop a series of satellites with varying sizes based on similar architectures. Applying product family concepts could allow satellite manufacturers to lower cost, shorten development cycles, and reduce market risk by catering to a number of market segments. This paper formulates the satellite product line design problem into a multiobjective optimization problem that characterizes the tradeoffs and resolves the tension between product line commonalities and the performance of each of the product line individual satellites. This research couples a Genetic Algorithm (GA), which is an evolutionary global search method that mimics the behavior of biological populations, with a satellite sizing model to find optimal product lines with common technology choices. The preliminary results demonstrate the effectiveness of the multiobjective optimization approach in applying product family concepts to the design of commercial communication satellites. NOMENCLATURE
Bone‐particle‐impregnated bone cement: An in vivo weight‐bearing study (1991)

To evaluate an experimental inorganic-bone-particle-impregnated bone cement, canine hip prostheses were implanted in dogs using a regular bone cement on one side and the experimental bone cement on the other. In a preliminary feasibility study, bone ingrowth into the resorbed bone-particle spaces was established 3 months after implantation in three dogs. In a more detailed study, twenty-eight (28) dogs were divided in four groups to delineate the effects of time on the phenomena of bony ingrowth. One month after implantation, active bone ingrowth into the bone cement was obvious. By 3 months postimplantation, the ingrowth appeared to have traversed the thickness of the bone-particle-impregnated cement. By the fifth month, most of the interconnected inorganic bone particles were replaced by new bone. At the end of a year, the ingrown bone was mature and negligible new bone activity was present. Biomechanical pushout tests closely corroborated the histologic observations. The maximum shear strength of the cement/bone interface of the experimental side reached 3.6 times that of the control side at 5 months postimplantation. No further improvements were seen at 12 months postimplantation. A viable bone/cement interface may result in a better orthopedic implant fixation system by combining the advantages of both cement for immediate rigidity and biological ingrowth for longterm stability.
Bright beam deflection by steering beams with mixed phase dislocations (2008)

We study the ability of beams carrying mixed step-screw phase dislocations to guide and steer probe beams with nonzero transverse velocity. We report the first experimental demonstration of bright signal beam deflection by steering odd beams of finite length carrying such dislocation. The numerical simulations show that the beam deflection can be ruled by the geometry and orientation of the dislocation.
CT7 (MAGE‐C1) antigen expression in normal and neoplastic tissues (2002)

CT7 (MAGE-C1) is a member of the cancer testis (CT) antigen family. The present study describes the generation of CT7-33, a monoclonal antibody (MAb) to CT7, and the preliminary protein expression analysis of CT7 in normal tissues and in a limited number of neoplastic lesions. CT7-33 was effective in frozen as well as formalin-fixed, paraffin-embedded tissues, and immunohistochemistry/reverse transcriptase polymerase chain reaction (RT-PCR) co-typing demonstrated antibody specificity. CT7-33 immunoreactivity in normal adult tissues is restricted to testicular germ cells. In neoplastic lesions, CT7-33 immunostaining is confined to tumor cells, and the frequency of CT7 protein expression mostly parallels previous mRNA analyses. Whereas colorectal and renal cell carcinomas, as well as sarcomas, exhibit poor or no CT7-33 staining, carcinomas of the mammary gland and ovary, nonsmall cell lung carcinoma and metastatic melanomas exhibit a high incidence of CT7 protein expression. However, as seen in previous analyses of other CT antigens, the expression pattern is mostly heterogeneous, and tumors with more than 50% of tumor staining are only infrequently encountered. In summary, our study presents a new serologic reagent for the analysis of CT7 on a protein level and confirms what is known with regard to the expression pattern of other CT antigens in tumors: frequent heterogeneity of antigen expression.
Inscription of Fiber Bragg Gratings in Multicore Fiber (2007)

We present solutions to unique problems associated with simultaneously writing fiber Bragg gratings in 4 cores of a multicore fiber used for bend and twist sensing, including exposure conditions, photosensitivity balance, and draw-induced refractive index changes.