gebhart/patrepeval huggingface dataset:
AERODYNAMIC AND MYOELASTIC CONTRIBUTIONS TO TRACHEOESOPHAGEAL VOICE PRODUCTION (LARYNGECTOMY, ALARYNGEAL, SPEECH) (1985)

Some patients with laryngeal cancer require surgical removal of the larynx. Laryngectomized patients often use a surgically reconstructed, upper esophageal sphincter as a substitute voice source during the production of esophageal and tracheoesophageal speech. There is limited published information concerning physiological bases of these two types of alaryngeal voice production. The present project was undertaken to examine aerodynamic and myoelastic contributions to tracheoesophageal voice production on a systematic basis. A specific aim was to test the hypothesis that laryngectomized individuals are incapable of adjusting their voicing source to influence its vibratory rate during voice production. A second aim was to define specific contributions aerodynamic influences make to mediating tracheoesophageal voice. Five laryngectomized, tracheoesophageal speakers served as subjects. They completed two experimental tasks in which they produced vowels (1) at different trans-source airflow rates, and (2) while varying fundamental frequency. The present project was undertaken under the assumption that tracheoesophageal voice production is an aerodynamic event. The results confirm this assumption. Large intersubject differences in average fundamental frequency, trans-source airflow rate, tracheal pressure, and airway resistance were found. Variations in fundamental frequency produced by these tracheoesophageal speakers were always associated with significant positive changes in tracheal pressure. Less consistent relationships were established between fundamental frequency and trans-source airflow rate, and between fundamental frequency and airway resistance. These findings were interpreted to suggest that the single most important aerodynamic mediator of fundamental frequency change in tracheoesophageal voice is driving pressure. A major finding of the present project was that tracheoesophageal speakers were capable of adjusting their voicing source on a systematic basis to influence its vibratory rate during voice production. Taken together, findings were interpreted to suggest that tracheoesophageal voice production should be regarded as a myoelastic-aerodynamic event. Findings were interpreted in relation to existing hypotheses about physiological mechanisms underlying tracheoesophageal voice production and in terms of identifying promising areas of future research.
Chlorzoxazone or 1-EBIO increases Na+absorption across cystic fibrosis airway epithelial cells (2001)

Previous studies demonstrated that chlorzoxazone or 1-ethyl-2-benzimidazolinone (1-EBIO) enhances transepithelial Cl(-) secretion by increasing basolateral K(+) conductance (G(K)) (Singh AK, Devor DC, Gerlach AC, Gondor M, Pilewski JM, and Bridges RJ. J Pharmacol Exp Ther 292: 778-787, 2000). Hence these compounds may be useful to treat cystic fibrosis (CF) airway disease. The goal of the present study was to determine whether chlorzoxazone or 1-EBIO altered ion transport across Delta F508-CF transmembrane conductance regulator homozygous CFT1 airway cells. CFT1 monolayers exhibited a basal short-circuit current that was abolished by apical amiloride (inhibition constant 320 nM) as expected for Na(+) absorption. The addition of chlorzoxazone (400 microM) or 1-EBIO (2 mM) increased the amiloride-sensitive I(sc) approximately 2.5-fold. This overlapping specificity may preclude use of these compounds as CF therapeutics. Assaying for changes in the basolateral G(K) with a K(+) gradient plus the pore-forming antibiotic amphotericin B revealed that chlorzoxazone or 1-EBIO evoked an approximately 10-fold increase in clotrimazole-sensitive G(K). In contrast, chlorzoxazone did not alter epithelial Na(+) channel-mediated currents across basolateral-permeabilized monolayers or in Xenopus oocytes. These data further suggest that alterations in basolateral G(K) alone can modulate epithelial Na(+) transport.
Highly Efficient, Water‐Soluble Polarizing Agents for Dynamic Nuclear Polarization at High Frequency (2013)

Gut polarisiert: Zwei neue Polarisationsreagentien, PyPol und AMUPol, wurden für die NMR-Spektroskopie mit dynamischer Kernpolarisation (DNP) entwickelt. Die Verstärkungsfaktoren (ε) bei 263 und 395 GHz sind 3.5- bis 4-mal größer als für das etablierte Reagens TOTAPOL. Im Fall von AMUPol können dank der Temperaturabhängigkeit von ε die DNP-Experimente bei beträchtlich höheren Temperaturen durchgeführt werden als typische Hochfeld-DNP-NMR-Experimente.
Nanoengineering Of Structural Materials (2020)

His research interests include manufacturing of composite materials, finite element modeling, fracture mechanics, high temperature materials, ceramics and composites. Specifically, his work has included the low cost manufacturing of composite materials, damage characterization of thin and thick composite laminates subjected to low velocity impact loadings, three dimensional finite element micro mechanics modeling of composites, modeling of textile composites, geometrically nonlinear plate and membrane problems, modeling of ceramic composites, fracture toughness studies of high strength materials, finite element modeling of offset car crash simulations.
Cramer-Rao bounds for estimating range, velocity, and direction with a sensor array (2002)

We derive Cramer-Rao bound (CRB) expressions for the range (time delay), velocity (Doppler shift), and direction of a point target using an active radar or sonar array. The CRB expressions are derived for an arbitrary signal waveform and a noise model that allows both spatial and temporal correlation. We discuss the relationship between the CRB and ambiguity function for this model. Then, we simplify the CRB for the cases of temporally or spatially uncorrelated noise. We compute the CRB for a 3-dimensional array with isotropic sensors in spatially uncorrelated noise and show that it is a function of the array geometry only through the "moments of inertia" of the array. The volume of the confidence region for the target's location is proposed as a measure of accuracy. For this measure, we show that the highest (and lowest) target location accuracy is achieved if the target lies along one of the principal axes of inertia of the array.
Production of Gasoline Fuel from Alga‐Derived Botryococcene by Hydrogenolysis over Ceria‐Supported Ruthenium Catalyst (2017)

Abstract Hydrogenolysis of hydrogenated botryococcene (Hy‐Bot) was conducted over various supported Ru catalysts, Ir/SiO 2 , and Pt/SiO 2 –Al 2 O 3 . Ru/CeO 2 with very high dispersion showed the highest yield (70 %) of gasoline‐range (C5–C12) alkanes at 513 K. The main gasoline‐range products were dimethylalkanes. This yield is comparable to or higher than the gasoline yields from botryococcene in the literature, which were obtained at much higher temperature. Ir/SiO 2 also showed a high fuel yield, but the activity was much lower than that with the Ru catalysts. The reaction over Pt/SiO 2 –Al 2 O 3 slowed down before total conversion of Hy‐Bot was achieved. Ru/CeO 2 was stable in the hydrogenolysis of Hy‐Bot without loss of activity and selectivity during reuses. The carbon balance was low for the hydrogenolysis of Hy‐Bot over all catalysts if the main products are heavy hydrocarbons, whereas for the hydrogenolysis of squalane the carbon balance was kept near 100 %. 1 H NMR spectra of the product mixture and thermogravimetric analyses of the product mixture and the recovered catalyst revealed that the formation of aromatic compounds, polymeric products, and coke was negligible for the carbon balance. In a model reaction using substrate compounds with a substructure of Hy‐Bot, only 2,5‐dimethylhexane, which has a C6 chain with two C primary −C tertiary bonds, produced a cyclic product, 1,4‐dimethylcyclohexane, which has a higher boiling point than the substrate. This dehydrocyclization reaction makes the product distribution in the hydrogenolysis of Hy‐Bot more complex.
The Relationship between Runs of Homozygosity and Inbreeding in Jersey Cattle under Selection (2015)

Inbreeding is often an inevitable outcome of strong directional artificial selection but on average it reduces population fitness with increased frequency of recessive deleterious alleles. Runs of homozygosity (ROH) representing genomic autozygosity that occur from mating between selected and genomically related individuals may be able to reveal the regions affecting fitness. To examine the influence of genomic autozygosity on fitness, we used a genome-wide association test to evaluate potential negative correlations between ROH and daughter pregnancy rate (DPR) or somatic cell score (SCS) in US Jersey cattle. In addition, relationships between changes of local ROH and inbreeding coefficients (F) were assessed to locate genomic regions with increased inbreeding. Despite finding some decreases in fertility associated with incremental increases in F, most emerging local ROH were not significantly associated with DPR or SCS. Furthermore, the analyses of ROH could be approximated with the most frequent haplotype(s), including the associations of ROH and F or traits. The analysis of the most frequent haplotype revealed that associations of ROH and fertility could be accounted for by the additive genetic effect on the trait. Thus, we suggest that a change of autozygosity is more likely to demonstrate footprints of selected haplotypes for production rather than highlight the possible increased local autozygosity of a recessive detrimental allele resulting from the mating between closely related animals in Jersey cattle.
Enhancement of ferromagnetism by substituting Cu for Mn in Ni-Mn-In-B Heusler alloys (2017)

The effects of substituting Cu for Mn on the magnetocaloric, transport, and thermomagnetic properties of Ni50Mn35-xCuxIn14B (x = 0, 1.25, 2.0) Heusler alloys were studied. It has been found that the magnitude of the magnetization jump at the martensitic transformation decreased with increasing Cu concentration. Smaller magnetic entropy changes (∆SM) were observed for the alloys with higher Cu concentrations. A decrease in the resistivity was observed with increasing Cu concentration. The magnetoresistance was dramatically suppressed with increasing Cu concentration due to the weakening of the antiferromagnetic (AFM) interactions in the martensitic phase. The experimental results demonstrate that Cu in Ni50Mn35-xCuxIn14B Heusler alloys suppresses the AFM interactions and enhances the ferromagnetic (FM) interactions in these alloys. Possible mechanisms responsible for the observed behavior are discussed.
The Oxidation States of Astatine in Aqueous Solution1 (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Oxidation States of Astatine in Aqueous Solution1Evan H. AppelmanCite this: J. Am. Chem. Soc. 1961, 83, 4, 805–807Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://pubs.acs.org/doi/10.1021/ja01465a014https://doi.org/10.1021/ja01465a014research-articleACS PublicationsRequest reuse permissionsArticle Views227Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Improved Model to Predict Reservoir Characteristics During Underbalanced Drilling (2003)

Abstract We present an algorithm and an approach for the coupling of a 2-phase, 2-dimensional transient reservoir simulator using a control volume finite element approach, and a 2-phase transient mechanistic multiphase wellbore flow model to dynamically characterize reservoirs while drilling underbalanced. This approach succeeds in accounting for storage effects in both the wellbore and reservoir. The coupling is achieved at the wellbore flowing pressure for given injection parameter and back pressure time functions, and the inverse problem is posed as one of minimizing the difference between predicted and observed return parameter time functions. A genetic algorithm (GA) approach, coupled with a one dimensional search scheme is used to achieve optimization. This paper focuses on one aspect of dynamic reservoir characterization-the prediction of permeability as a function of drill depth. Permeability results are obtained for an example problem and the accuracy and limitations of the proposed approach are discussed. Numerical problems in dealing with the grossly different time scales of reservoir and wellbore behavior, and practical limitations of reservoir characterization during underbalanced drilling are described. Improvements to the algorithm and future work are also discussed.
The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo (2017)

We conclude that ELF2 isoforms are important regulators of cellular proliferation, cell cycle progression, and apoptosis. In respect to this, ELF2B acts in a dominant negative fashion compared to ELF2A and as a putative tumour suppressor gene. Given that these cellular processes are critical during haemopoiesis, we propose that the regulatory interplay between ELF2 isoforms contributes substantially to early B and T cell development.
To What Extent Can the Current Amplitude Linearity of Rogowski Coils Be Verified? (2011)

Calibrations of Rogowski coils at power frequencies are often performed at currents of only tens of amperes even though the coils are used at currents larger by two to three orders of magnitude, or even more. The assumption of an ideal linearity versus current amplitude is true for ideal coils. This paper addresses the question on practical significance as to what extent the current amplitude linearity of real Rogowski coils can be verified at power frequencies. For this task, several different types of Rogowski coils were evaluated using a digital sampling system, with the best calibration uncertainties <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$(k = 2)$</tex></formula> of 50 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu\hbox{A/A}$</tex></formula> for magnitude and 50 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu\hbox{rad}$</tex></formula> for phase and the estimated linearity better by a factor of two or more.
Nuclear magnetic field measurement of the spin-exchange optically pumped noble gas in a self-compensated atomic comagnetometer (2020)

We demonstrate a new method to determine the nuclear magnetic field of the spin-exchange optically pumped noble gas in a self-compensated atomic comagnetometer based on the steady-state AC response. The result shows that it has higher resolution and precision than a previous method based on the transient process. Furthermore, a convergence frequency is observed in the low-frequency region and its parameter dependence is studied simulatively, which may inspire further research into its relationship with the strong suppression mechanism of the self-compensation ability for the low-frequency magnetic field. We also prove that this method can be developed for suppression of residual main magnetic field to improve the systematic stability of the comagnetometer.
Congenital Zika Syndrome in 2017 (2017)

This commentary discusses a case series of infants with congenital Zika virus infection published in JAMA Neurology that described developmental abnormalities more severe than had been previously reported.
Synthesis and Self-Assemble Behavior of Block Copolymerization of Vinyl Acetate and N-Vinylacetamide (2013)

Polymerizations of VAc was carried out using AIBN as the initiator and DIP as the MADIX agent precursor. Then, block copolymer PVAc-b-PNVA had been synthesized by RAFT radical polymerization in the presence of PVAc-DIP as macro CTA. The length of blocks could be tuned by changing the molar ratio of NVA and VAc. Block copolymer PVAc-b-PNVA self-assembled into micelles in solution, and underwent microphase separation in bulk state.
Medication Management in Belgian Residential Care Facilities for Individuals With Intellectual Disability: An Observational Study (2014)

Abstract Organizational aspects of the medication management process ( MMP ) have been investigated in hospital and nursing home settings. However, the amount of literature on medication management in residential care facilities ( RCF ) for individuals with ID is limited to two studies from the N etherlands, focusing only on drug administration errors. To assess the organization of the MMP in B elgian RCFs for people with ID , the authors undertook a cross‐sectional observational study in 34 Belgian RCFs for people with ID . Structured interviews were performed using a questionnaire: the first part (for the RCF directors) addressed administrative and policy issues. The second (for unit employees) and third parts (for medical office employees) addressed practical aspects of the MMP . The fourth part (for physicians) focused on the physician's role in the MMP , on the therapeutic drug formulary, and on communication with staff and delivering pharmacist. Standard operating procedures concerning the MMP were not available in 32% of the RCFs . About one‐quarter of the RCFs did not have a medication error reporting system, and most RCFs did not systematically (i.e., at least annually) review their MMP for failures. Only two participating RCFs were equipped with an electronic prescribing system. The role of the pharmacist was mainly limited to delivery of medication. Medication was mostly administered by nonmedically qualified staff (e.g., educators). Most frequently cited problems by the interviewees were problems in the medication preparation and administration stage. Most frequently cited possible improvement actions were education/sensitization of staff and improved communication among all stakeholders. The authors note that as this study revealed operational inadequacies, problem areas can be identified and targeted quality improvement actions can be undertaken.
ATPG-based cost-effective, secure logic locking (2018)

The globalization of IC supply chain lead to the emergence of hardware security threats such as IP piracy, reverse engineering, overbuilding, and hardware Trojans. Among the techniques developed to mitigate these threats, logic locking offers the most versatile protection and is being actively researched. The most recent locking technique SFLL thwarts with provable and quantifiable security all the state-of-the-art attacks including SAT, AppSAT, and the removal attack. However, the implementation cost of SFLL can sometimes be prohibitive, as it lacks an automated framework that explores cost-effective implementation options. In this paper, we show how VLSI testing principles and tools can be adopted to automate critical steps in SFLL and minimize its cost. We propose “SFLL-fault” that utilizes fault injection driven synthesis to efficiently explore design options and ATPG to assess security levels. Our experimental results confirm the efficacy of our strategy; SFLL-fault can reduce the implementation cost by 35% compared to SFLL without compromising security.
CTXφ and Vibrio cholerae: exploring a newly recognized type of phage–host cell relationship (2005)

The genes encoding cholera toxin, one of the principal virulence factors of the diarrhoeal pathogen Vibrio cholerae, are part of the genome of CTXphi, a filamentous bacteriophage. Thus, CTXphi has played a critical role in the evolution of the pathogenicity of V. cholerae. Unlike the well-studied F pilus-specific filamentous coliphages, CTXphi integrates site-specifically into its host chromosome and forms stable lysogens. Here we focus on the CTXphi life cycle and, in particular, on recent studies of the mechanism of CTXphi integration and the factors that govern lysogeny. These and other processes illustrate the remarkable dependence of CTXphi on host-encoded factors.
<title>Single-panel reflective LCD projector</title> (1999)

We have constructed a high resolution projection display with a single reflective LCD panel. Reflective technology based on standard silicon CMOS processing has emerged as a favorable direction for projection displays. Advantages include low investment and fabrication costs, high resolution capability, and high aperture ratio. As a move towards lower cost and high performance, we have applied reflective technology to a single panel projection display. The pixel array is SXGA and is fabricated in a process with both 5 Volt logic and 15 Volt structures. A thin 1 micron liquid crystal cell is formed over the array. A fast on time of 0.2 ms is attained with a nematic LC effect. System architecture is based upon a scrolling color illumination system wherein three color bands are present on the panel at all times. This arrangement avoids the 2/3 light loss in spectral efficiency present in a more conventional color wheel system. The system demonstrates that color sequential projection displays are feasible with LCD devices. And this direction holds great promise in a wide variety of applications including consumer HDTV displays.
Test chip for bump bond yield evaluation in high density flip chip technologies (2005)

Modern flip chip technologies for imaging applications have achieved a very high integration level together with the possibility of large assemblies. These developments have resulted in an enormous increase in the total number of bump bonds per assembly. As a result, yield tests become more difficult, and an accurate measurement of it is often discarded. This problem is aggravated in medical applications, as the critical information can be limited to a few pixels, and therefore, yields should be very close to 100%. In these cases, a difference of a few tenths percent in bump bond yield can make the difference between a usable and a nonusable assembly. For this reasons, quantitative and precise measurements of bump bond yield are needed to characterize the quality of any high density flip chip technology. In this contribution, we present a newly developed test chip for quantitative electrical characterization of the bump bond yield of high density flip chip technologies, allowing optimization and statistical control of the process. This test chip facilitates the identification of possible technological problems with precise quantitative yield measurements. It also allows to pin point any localized systematic failure in the bump-bonding process. The test chip has been used to evaluate the yield of different flip chip technologies and has contributed to their fine optimization
Alpha-cluster pickup reactions on even Sn and Te nuclei (1978)

Peer Reviewed