gebhart/patrepeval huggingface dataset:
Coupled Transient Thermal Analyses of Passive Cooling Traction PMSM from the Racing Formula (2021)

This paper is focused on the transient thermal model of the Permanent Magnet Synchronous Motor (PMSM) and the airflow cooling model through the ribs in the stator lamination. The stator lamination has a new specialized designed shape. This type of lamination does not need a frame, and the lamination is directly cooled. It has reduced the thermal resistance between the cooling medium and stator lamination. The thermal model is loaded with variable Power, and the airflow speed of cooling air is variable. Thermal models are solved by software ANSYS CFX and Mechanical. The thermal model of PMSM is based on the traction motor. This machine is designed as enclosed. The modelled PMSM is used in the electric racing formula.
CatWalk-Assisted Gait Analysis in the Assessment of Spinal Cord Injury (2006)

Gait analysis plays an important role in the assessment of neurological function in many disease models. In this review, we focus on the newly developed CatWalk system for gait analysis. CatWalk was originally developed as a tool to enhance assessment of functional outcome in spinal cord injury (SCI) models. Although it is also of value in models of among others (neuropathic) pain and peripheral nerve damage, we will limit ourselves to its use in SCI models in this review. The system is positioned against well-established locomotor function tests, and it is indicated how CatWalk can enhance the usefulness of such tests. Development of the system started with the idea that it should enable objective assessment of coordination, and powerful measures of coordination are nowadays included in the analysis options provided by CatWalk. Therefore, a major part of this review is devoted to the history and meaning of these coordination measures.
High yield synthesis of electrolyte heating assisted electrochemically exfoliated graphene for electromagnetic interference shielding applications (2015)

Demonstration of high yield synthesis of graphene by electrolyte heating assisted electrochemically exfoliation method for high performance EMI shielding applications.
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease. (2007)

Base excision repair (BER) pathway executed by a complex network of proteins is the major system responsible for the removal of damaged DNA bases and repair of DNA single strand breaks (SSBs) generated by environmental agents, such as certain cancer therapies, or arising spontaneously during cellular metabolism. Both modified DNA bases and SSBs with ends other than 3'-OH and 5'-P are repaired either by replacement of a single or of more nucleotides in the processes called short-patch BER (SP-BER) or long-patch BER (LP-BER), respectively. In contrast to Escherichia coli cells, in human ones, the two BER sub-pathways are operated by different sets of proteins. In this review the selection between SP- and LP-BER and mutations in BER and end-processors genes and their contribution to bacterial mutagenesis and human diseases are considered.
Experimental study of vortex breakdown in a cylindrical, swirling flow (1996)

The stability of a steady, vortical flow in a cylindrical container with one rotating endwall has been experimentally examined to gain insight into the process of vortex breakdowwn. The dynamics of the flow are governed by the Reynolds number (Re) and the aspect ratio of the cylinder. Re is given by Omega R(sup 2)/nu, where Omega is the speed of rotation of the endwall, R is the cylinder radius, and nu is the kinematic viscosity of the fluid filling the cylinder. The aspect ratio is H/R, where H is the height of the cylinder. Numerical simulation studies disagree whether or not the steady breakdown is stable beyond a critical Reynolds number, Re(sub c). Previous experimental researches have considered the steady and unsteady flows near Re(sub c), but have not explored the stability of the steady breakdown structures beyond this value. In this investigation, laser induced fluorescence was utilized to observe both steady and unsteady vortex breakdown at a fixed H/R of 2.5 with Re varying around Re(sub c). When the Re of a steady flow was slowly increased beyond Re(sub c), the breakdown structure remained steady even though unsteadiness was possible. In addition, a number of hysteresis events involving the oscillation periods of the unsteady flow were noted. The results show that both steady and unsteady vortex breakdown occur for a limited range of Re above Re(sub c). Also, with increasing Re, complex flow transformations take place that alter the period at which the unsteady flow oscillates.
Radiation characterization summary : ACRR 44-inch lead-boron bucket located in the central cavity on the 32-inch pedestal at the core centerline (ACRR-LB44-CC-32-cl). (2013)

This document presents the facility-recommended characterization of the neutron, prompt gamma-ray, and delayed gamma-ray radiation fields in the Annular Core Research Reactor (ACRR) for the 44-inch-long lead-boron bucket in the central cavity on the 32-inch pedestal at the core centerline. The designation for this environment is ACRR-LB44-CC-32-cl. The neutron, prompt gamma-ray, and delayed gamma-ray energy spectra are presented as well as radial and axial neutron and gamma-ray flux profiles within the experiment area of the bucket. Recommended constants are given to facilitate the conversion of various dosimetry readings into radiation metrics desired by experimenters. Representative pulse and steady-state operations are presented with conversion examples.
Subdiffusive Dynamics of Bump Attractors: Mechanisms and Functional Roles (2014)

Bump attractors are localized activity patterns that can self-sustain after stimulus presentation, and they are regarded as the neural substrate for a host of perceptual and cognitive processes. One of the characteristic features of bump attractors is that they are neutrally stable, so that noisy inputs cause them to drift away from their initial locations, severely impairing the accuracy of bump location-dependent neural coding. Previous modeling studies of such noise-induced drifting activity of bump attractors have focused on normal diffusive dynamics, often with an assumption that noisy inputs are uncorrelated. Here we show that long-range temporal correlations and spatial correlations in neural inputs generated by multiple interacting bumps cause them to drift in an anomalous subdiffusive way. This mechanism for generating subdiffusive dynamics of bump attractors is further analyzed based on a generalized Langevin equation. We demonstrate that subdiffusive dynamics can significantly improve the coding accuracy of bump attractors, since the variance of the bump displacement increases sublinearly over time and is much smaller than that of normal diffusion. Furthermore, we reanalyze existing psychophysical data concerning the spread of recalled cue position in spatial working memory tasks and show that its variance increases sublinearly with time, consistent with subdiffusive dynamics of bump attractors. Based on the probability density function of bump position, we also show that the subdiffusive dynamics result in a long-tailed decay of firing rate, greatly extending the duration of persistent activity.
A Tri-Band Bandpass Filter With Wide Stopband Using Asymmetric Stub-Loaded Resonators (2014)

This letter presents a tri-band bandpass filter (BPF) with a wide stopband using asymmetric stub-loaded resonators (ASLR). A tri-band filter sample was fabricated by using two ASLRs with coupled I/O ports. By properly tuning the electrical length ratios of the ASLRs ( α and γ), three passbands can be designed at 1.4, 2.4, and 3.5 GHz. The harmonic responses are suppressed effectively by forming an uncoupled section at the end of the ASLRs, and the stopband region is formed from 3.7 to 7 GHz with a rejection level of 30 dB. The measured results of the fabricated tri-band BPF exhibit good agreement with simulated results.
Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1 (2021)

Background Natural killer (NK) cells require a functional lytic granule machinery to mediate effective antitumor responses. Evading the lytic cargo deployed at the immune synapse (IS) could be a critical step for cancer progression through yet unidentified mechanisms. Methods NK cell antibody-dependent cellular cytotoxicity (ADCC) is a major determinant of the clinical efficacy of some therapeutic antibodies including the anti-HER2 Trastuzumab. Thus, we screened sera of Trastuzumab-resistant HER2 +patients with breast cancer for molecules that could inhibit NK cell ADCC. We validated our findings in vitro using cytotoxicity assays and confocal imaging of the lytic granule machinery and in vivo using syngeneic and xenograft murine models. Results We found that sera from Trastuzumab-refractory patients could inhibit healthy NK cell ADCC in vitro. These sera contained high levels of the inflammatory protein chitinase 3-like 1 (CHI3L1) compared with sera from responders and healthy controls. We demonstrate that recombinant CHI3L1 inhibits both ADCC and innate NK cell cytotoxicity. Mechanistically, CHI3L1 prevents the correct polarization of the microtubule-organizing center along with the lytic granules to the IS by hindering the receptor of advanced glycation end-products and its downstream JNK signaling. In vivo, CHI3L1 administration drastically impairs the control of NK cell-sensitive tumors, while CHI3L1 blockade synergizes with ADCC to cure mice with HER2 +xenografts. Conclusion Our work highlights a new paradigm of tumor immune escape mediated by CHI3L1 which acts on the cytotoxic machinery and prevents granule polarization. Targeting CHI3L1 could mitigate immune escape and potentiate antibody and cell-based immunotherapies.
A Two-Element Biomimetic Antenna Array With Enhanced Angular Resolution and Optimized Power Extraction (2014)

A new architecture for a two element biomimetic antenna array (BMAA) is presented. This two-element BMAA is in the form of a coupled antenna array with an external coupling network that is designed to efficiently extract power from both linearly-independent modes of excitation of the array. These include the common mode and the differential modes of excitation. This new array offers an enhanced phase response compared to the regular antenna array that occupies the same aperture. However, unlike previous BMAA designs, the output power of the array does not need to be sacrificed to achieve this phase enhancement factor. Compared to a regular array, this two-element coupled array extracts the same amount of power from an incoming electromagnetic wave but provides a considerably larger phase sensitivity. The paper describes the theory of operation and the design process of this antenna. Using the design procedure presented in this paper, a prototype of such a two-element BMAA is designed and experimentally characterized in the lab. Measurement results confirm the advantages of this new design compared to the previous BMAAs reported in the literature.
EXIT ChartAnalysisof Binary (2007)

Binary message-passing decoders forLDPC codes areanalyzed using EXITcharts. Fortheanalysis, thevariable nodedecoder performs allcomputations intheL-value domain. Forthespecial caseofa harddecision channel, thisleadsto thewell-know Gallager B algorithm, whiletheanalysis canbe extended tochannels withlarger output alphabets. Byincreasing theoutput alphabet fromharddecisions tofoursymbols, again ofmorethan1.0dBisachieved using optimized codes. Forthis codeoptimization, themixing property ofEXITfunctions hasto bemodified tothecaseofbinary message-passing decoders.
Comparison of Speech Recognition and Localization Performance in Bilateral and Unilateral Cochlear Implant Users Matched on Duration of Deafness and Age at Implantation (2008)

The average group results in this study showed significantly greater benefit on words and sentences in quiet and localization for listeners using two cochlear implants over those using only one cochlear implant. One explanation of this result might be that the same information from both sides are combined, which results in a better representation of the stimulus. A second explanation might be that CICI allow for the transfer of different neural information from two damaged peripheral auditory systems leading to different patterns of information summating centrally resulting in enhanced speech perception. A future study using similar methodology to the current one will have to be conducted to determine if listeners with two cochlear implants are able to perform better than listeners with one cochlear implant in noise.
Enhanced Cell Response to Zirconia Surface Immobilized with Type I Collagen (2019)

Zirconia (ZrO<sub>2</sub>) dental implants provide good biocompatibility, have good corrosion resistance, and have a color that is similar to that of natural teeth. Unfortunately, ZrO<sub>2</sub> is a bioinert material and therefore achieves osseointegration difficultly. In this study, we sought to enhance osseointegration by producing rough ZrO<sub>2</sub> surfaces that contain hydroxyl groups (designated ZSA) through the use of sandblasting in conjunction with alkaline treatment. We immobilized type I collagen on ZSA surfaces using the natural cross-linker, procyanidin. Our results further showed that surfaces produced in ZSA-P/C featured more and steadier type I collagen than surfaces produced in ZSA-C. The ZSA-P/C also presented superior cell responses in terms of adhesion, proliferation, and mineralization of human bone marrow mesenchymal stem cells. The enhanced cell responses in the ZSA-P/C were induced through the prolonged activation of focal adhesion kinase, AKT (the phosphoinositide 3-kinase pathway), and p38 (the mitogen-activated protein kinase pathway). The simple and novel approach to immobilize type I collagen on roughened ZrO<sub>2</sub> surfaces presented in this article can likely benefit dental implant applications.
Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets (2011)

The p53-family member TAp73 is a transcription factor that plays a key role in many biological processes. Here, we show that p73 drives the expression of microRNA (miR)-34a, but not miR-34b and -c, by acting on specific binding sites on the miR-34a promoter. Expression of miR-34a is modulated in parallel with that of TAp73 during in vitro differentiation of neuroblastoma cells and cortical neurons. Retinoid-driven neuroblastoma differentiation is inhibited by knockdown of either p73 or miR-34a. Transcript expression of miR-34a is significantly reduced in vivo both in the cortex and hippocampus of p73(-/-) mice; miR-34a and TAp73 expression also increase during postnatal development of the brain and cerebellum when synaptogenesis occurs. Accordingly, overexpression or silencing of miR-34a inversely modulates expression of synaptic targets, including synaptotagmin-1 and syntaxin-1A. Notably, the axis TAp73/miR-34a/synaptotagmin-1 is conserved in brains from Alzheimer's patients. These data reinforce a role for TAp73 in neuronal development.
Controlling Piezoelectric Response in Semiconductor Quantum Dots via Impulsive Charge Localization (2010)

By direct observation of coherent acoustic phonons, we demonstrate a novel extrinsic piezoelectric response in colloidal CdSe semiconductor quantum dots. This response is driven by the migration of charges to the surface of the quantum dot on a vibrationally impulsive time scale. Surface- and fluence-dependent studies reveal that the observed carrier capture based piezo response is controllable and is at least an order of magnitude larger than the intrinsic piezo response of wurtzite CdSe.
When You Got It, Bump It: A Lost Showgirl’s Cabaret (2011)

In mammals, the sense of hearing arises through a complex sequence of morphogenetic events that drive the sculpting of the auditory sensory epithelium into its terminally functional three-dimensional shape. While the majority of the underlying mechanisms remain unknown, it has become increasingly clear that Ca<sup>2+</sup> signaling is at center stage and plays numerous fundamental roles both in the sensory hair cells and in the matrix of non-sensory, epithelial and supporting cells, which embed them and are tightly interconnected by a dense network of gap junctions formed by connexin 26 (Cx26) and connexin 30 (Cx30) protein subunits. In this review, we discuss the intricate interplay between Ca<sup>2+</sup> signaling, connexin expression and function, apoptosis and autophagy in the crucial steps that lead to hearing acquisition.
3D Map Registration using Vision/Laser and Inertial Sensing. (2007)

Abstract — A point cloud registration method is proposed in this article, and experimental results are presented for long threedimensional map sequences obtained from a moving observer. In vision based systems used in mobile robotics the perception of self-motion and the structure of the environment is essential. Inertial and earth field magnetic pose sensors can provide valuable data about camera ego-motion, as well as absolute references for the orientation of scene structure and features. In this work we explore the fusion of inertial and magnetic sensor data with range sensing devices. Orientation measurements from the inertial system are used to rotate the obtained 3D maps into a common orientation, compensating the rotational movement. Then, image correspondences are used to find the remaining translation. Results are presented using both a stereo camera and a laser range finder as the ranging device. The laser range finder also needs a single camera to stabilish pixel correspondence. The article overviews the camera-inertial and camera-laser calibration processes used. The map registration approach is presented and validated with experimental results on indoor and outdoor environments. Index Terms — Inertial Sensors, 3D Mapping, Laser Sensors I.
Establishing exchange bias belowTNwith polycrystallineNi0.52Co0.48O∕Cobilayers (2005)

Exchange-coupled bilayers of polycrystalline ferromagnetic (FM) Co on antiferromagnetic (AFM) ${\mathrm{Ni}}_{0.52}{\mathrm{Co}}_{0.48}\mathrm{O}$ were investigated with emphasis on the issue of establishing an exchange-bias field, ${H}_{E}$, below the AFM ordering temperature, ${T}_{N}$. It was found that field-cooling the bilayers through ${T}_{N}$ provided very little, if any, increase in ${H}_{E}$ over that produced by deposition of the Co at temperatures far below ${T}_{N}$. Further significant aspects of this issue were also examined. The biasing field, ${H}_{B}$, needed to be applied only during the deposition of a small fraction $(1\phantom{\rule{0.3em}{0ex}}\mathrm{nm})$ of the FM film below ${T}_{N}$ of the AFM to achieve the maximum ${H}_{E}$; if ${H}_{B}$ was reversed at any time during the FM deposition, ${H}_{E}$ was determined by the final direction of ${H}_{B}$; the direction of ${H}_{E}$ could be reversed after it had been established by applying a reversed field during a post-deposition latent period. These and other findings are considered with respect to clarification of the mechanisms for establishing ${H}_{E}$.
Synthesis of some conformationally restricted analogs of fentanyl (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of some conformationally restricted analogs of fentanylJoel G. Berger, Fredric Davidson, and Gordon E. LangfordCite this: J. Med. Chem. 1977, 20, 4, 600–602Publication Date (Print):April 1, 1977Publication History Published online1 May 2002Published inissue 1 April 1977https://pubs.acs.org/doi/10.1021/jm00214a035https://doi.org/10.1021/jm00214a035research-articleACS PublicationsRequest reuse permissionsArticle Views534Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MutT-related proteins are novel progression and prognostic markers for colorectal cancer (2017)

We showed for the first time that MutT-related proteins play an important role in CRC progression and prognosis. Further investigations are needed to elucidate the role of these proteins in CRC progression and their potential use for therapeutic targets.
Enhanced Modulation Technique for Molecular Communication: OOMoSK (2014)

Molecular communication in nanonetworks is an emerging communication paradigm where molecules are used as information carriers. Concentration Shift Keying (CSK) and Molecule Shift Keying (MoSK) are being studied extensively for the short and medium range molecular nanonetworks. It is observed that MoSK outperforms CSK. However, MoSK requires different types of molecules for encoding which render transmitter and receiver complexities. We propose a modulation scheme called On-Off MoSK (OOMoSK) in which, molecules are released for information bit 1 and no molecule is released for 0. The proposed scheme enjoys reduced number of the types of molecules for encoding. Numerical results show that the proposed scheme enhances channel capacity and Symbol Error Rate (SER).
<title>Tunable elastic stiffness of plasma-sprayed zirconia coatings</title> (1999)

Plasma-sprayed zirconia is widely used in aero-engines as thermal barrier coating material. The material has an open porosity and a network of very thin microcracks. The porosity and the microcracks give rise to the low elastic stiffness. When the plasm sprayed zirconia is immersed in a liquid the microcracks can be filled with the liquid by capillary forces. Although there is only a small amount of infiltrated material the zirconia shows a strong increase in elastic stiffness. We have measured the elastic behavior after infiltration and as function of temperature by ultrasonic pulse echo technique. It could be observed that the solidification of the infiltrated fluid at lower temperatures leads to a further increase of the elastic stiffness. The temperature controlled liquid-solid phase transition can therefore be used to change reversibly the elastic properties of this ceramic material. The desired switching temperature can be chosen by appropriate fluids. A possible application of this material is the vibration damping of coated structures by temperature controlled changing of resonance frequencies.