gebhart/patrepeval huggingface dataset:
Orthostatic hypotension occurs following α2‐adrenoceptor blockade in chronic prazosin‐pretreated conscious spontaneously hypertensive rats (1992)

1. Studies were performed to evaluate whether chronic prazosin treatment alters the alpha 2-adrenoceptor function for orthostatic control of arterial blood pressure in conscious spontaneously hypertensive rats (SHR). 2. Conscious SHR (male 300-350 g) were subjected to 90 degrees head-up tilts for 60 s following acute administration of prazosin (0.1 mg kg-1 i.p.) or rauwolscine (3 mg kg-1 i.v.). Orthostatic hypotension was determined by the average decrease (%) in mean arterial pressure (MAP femoral) over the 60-s tilt period. The basal MAP of conscious SHR was reduced to a similar extent by prazosin (-23%(-)-26% MAP) and rauwolscine (-16%(-)-33% MAP). However, the head-up tilt induced orthostatic hypotension in the SHR treated with prazosin (-16% MAP, n = 6), but not in the SHR treated with rauwolscine (less than +2% MAP, n = 6). 3. Conscious SHR were treated for 4 days with prazosin at 2 mg kg-1 day-1 i.p. for chronic alpha 1-adrenoceptor blockade. MAP in conscious SHR after chronic prazosin treatment was 14% lower than in the untreated SHR (n = 8). Head-up tilts in these rats did not produce orthostatic hypotension when performed either prior to or after acute dosing of prazosin (0.1 mg kg-1 i.p.). Conversely, administration of rauwolscine (3 mg kg-1 i.v.) in chronic prazosin treated SHR decreased the basal MAP by 12-31% (n = 4), and subsequent tilts induced further drops of MAP by 19-23% in these rats. 4. The pressor responses and bradycardia to the alpha 1-agonist cirazoline (0.6 and 2 micrograms kg-1 i.v.), the alpha 2-agonist Abbott-53693 (1 and 3 micrograms kg-1 i.v.), and noradrenaline (0.1 and 1.0 micrograms kg-1 i.v.) were determined in conscious SHR with and without chronic prazosin pretreatment. Both the pressor and bradycardia effects of cirazoline were abolished in chronic prazosin treated SHR (n = 4) as compared to the untreated SHR (n = 4). On the other hand, the pressor effects of Abbott-53693 were similar in both groups of SHR, but the accompanying bradycardia was greater in SHR with chronic prazosin treatment than without such treatment. Furthermore, the bradycardia that accompanied the noradrenaline-induced pressor effect in SHR was similar with and without chronic prazosin treatment despite a 47-71% reduction of the pressor effect in chronic alpha 1-receptor blocked SHR.(ABSTRACT TRUNCATED AT 400 WORDS)
Preparation of graphene by pressurized oxidation and multiplex reduction and its polymer nanocomposites by masterbatch-based melt blending (2012)

Graphene is prepared from graphite by pressurized oxidation and multiplex reduction. The pressurized oxidation is advantageous in easy operation and size-control, and the multiplex reduction, based on ammonia and hydrazine, produces single-atom-thick graphene (0.4–0.6 nm thick) which can be directly observed by atomic force microscopy. A masterbatch strategy, which is feasible in “soluble” thermoplastic polymers, is developed to disperse graphene into poly(lactic acid) by melt blending. The graphene is well dispersed and the obtained nanocomposites present markedly improved crystallinity, rate of crystallization, mechanical properties, electrical conductivity and fire resistance. The properties are dependent on the dispersion and loading content of graphene, showing percolation threshold at 0.08 wt%. Graphene reinforces the nanocomposites but cuts down the interactions among the polymer matrix, which leads to reduced mechanical properties. Competition of the reinforcing and the reducing causes inflexions around the percolation threshold. The roles of the heat barrier and mass barrier effects of graphene in the thermal degradation and combustion properties of the nanocomposites are discussed and clarified.
Current-induced domain wall motion in perpendicularly magnetized CoFeB nanowire (2011)

Current-induced domain wall motion in perpendicularly magnetized CoFeB nanowires with a stack structure of Ta(1.0 nm)/CoFeB(1.2 nm)/MgO(2.0 nm)/Ta(1.0 nm) was investigated. Domain wall motion driven by adiabatic spin-transfer torque was observed at a current of about 74 μA, corresponding to a current density of 6.2×107 A/cm2. The obtained results were compared with those of a micromagnetic simulation and the spin polarization of the CoFeB was estimated to be 0.72.
Hidden Markov Models Compared To The Wavelet Transform For P-Wave Segmentation In Egc Signals (1998)

Publication in the conference proceedings of EUSIPCO, Rhodes, Greece, 1998
Delineating a Ca2+ Binding Pocket within the Venus Flytrap Module of the Human Calcium-sensing Receptor (2005)

The Ca(2+)-sensing receptor (CaSR) belongs to the class III G-protein-coupled receptors (GPCRs), which include receptors for pheromones, amino acids, sweeteners, and the neurotransmitters glutamate and gamma-aminobutyric acid (GABA). These receptors are characterized by a long extracellular amino-terminal domain called a Venus flytrap module (VFTM) containing the ligand binding pocket. To elucidate the molecular determinants implicated in Ca(2+) recognition by the CaSR VFTM, we developed a homology model of the human CaSR VFTM from the x-ray structure of the metabotropic glutamate receptor type 1 (mGluR1), and a phylogenetic analysis of 14 class III GPCR VFTMs. We identified critical amino acids delineating a Ca(2+) binding pocket predicted to be adjacent to, but distinct from, a cavity reminiscent of the binding site described for amino acids in mGluRs, GABA-B receptor, and GPRC6a. Most interestingly, these Ca(2+)-contacting residues are well conserved within class III GPCR VFTMs. Our model was validated by mutational and functional analysis, including the characterization of activating and inactivating mutations affecting a single amino acid, Glu-297, located within the proposed Ca(2+) binding pocket of the CaSR and associated with autosomal dominant hypocalcemia and familial hypocalciuric hypercalcemia, respectively, genetic diseases characterized by perturbations in Ca(2+) homeostasis. Altogether, these data define a Ca(2+) binding pocket within the CaSR VFTM that may be conserved in several other class III GPCRs, thereby providing a molecular basis for extracellular Ca(2+) sensing by these receptors.
‘If I Could Just Touch the Hem of His Garment’ (2021)

Abstract This article proposes an ontology and praxis of mediation for the sake of ecumenical dialog, showing that the Pentecostal theological and spiritual tradition does not necessarily deny mediation or challenge its goodness, even if it does decry clericalism and ‘ecclesio-monism’. Instead, Pentecostals hold to confidence in the freedom of God to work however and whenever is best for us, always so that ‘the means of grace’ prove to be more than mere instruments or channels of divine power.
Aftereffects and Sense of Presence in Virtual Environments: Formulation of a Research and Development Agenda (1998)

This report represents a committee summary of the current state of knowledge regarding aftereffects and sense of presence in virtual environments (VEs). The work presented in this article, and the proposed research agenda, are the result of a special session that was set up in the framework of the Seventh International Conference on Human Computer Interaction. Recommendations were made by the committee regarding research needs in aftereffects and sense of presence, and, where possible, priorities were suggested. The research needs were structured in terms of the short, medium, and long term and, if followed, should lead toward the effective use of VE technology. The 2 most critical research issues identified were (a) standardization and use of measurement approaches for aftereffects and (b) identification and prioritization of sensorimotor discordances that drive aftereffects. Identification of aftereffects countermeasures (i.e., techniques to assist users in readily transitioning between the real and virtual worlds), reduction of system response latencies, and improvements in tracking technology were also thought to be of critical importance.
Erratum: The synthesis and transport properties of the complex salt (TMPD)(TCNQ)2 [J. Chem. Phys. 62, 1061 (1975)] (1975)

First Page
Abstract 694: TK-216: a novel, first-in-class, small molecule inhibitor of EWS-FLI1 in early clinical development, for the treatment of Ewing Sarcoma (2017)

Abstract One of the most significant challenges in creating more potent, less toxic treatments for patients is to identify new cancer therapeutic targets that distinguish the malignant from normal cells. EWS-FLI1 is a well-established Ewing sarcoma (ES) oncogene that has the potential to be an ideal therapeutic target by directly impacting malignant cells. We have previously reported the discovery and characterization of YK-4-279, an enantiomer-specific inhibitor of EWS-FLI1, which has been demonstrated to induce apoptosis, inhibit EWS-FLI1 transcription, block RNA helicase A co-immunoprecipitation with EWS-FLI1, and result in alternative splicing to mimic EWS-FLI1 knockdown. Continuous efforts in structure-guided medicinal chemistry has yielded TK-216, an analog of YK-4-279 inhibitor of EWS-FLI1, which is 3-4 fold more potent with excellent drug-like properties. TK-216 potently inhibits the proliferation of ES cells. Induces apoptosis in a dose -dependent manner as measured by caspase-3 activity in multiple ES cell lines with distinct translocation variants. The effects of TK-216 on alternative splicing (AS) were further validated using genes including ARID1A, CLK1, CASP3, PPFIBP1 and RUNX2. The splicing pattern was similar between TK-216 and YK-4-279. In addition to the in vitro activity of TK-216 , we show that TK-216 displays anti-tumor activity in a number of ES xenograft models. In summary, TK-216, a novel, first-in-class therapeutic which directly inhibits EWS-FLI1, offers a promising approach for the treatment of Ewing Sarcoma and is currently in Phase 1 clinical trials in patients with relapsed or refractory Ewing Sarcoma (clinicaltrials.gov - NCT02657005). Citation Format: Saravana P. Selvanathan, Eric Moseley, Garrett T. Graham, Katti Jessen, Brian Lannutti, Aykut Üren, Jeffrey A. Toretsky. TK-216: a novel, first-in-class, small molecule inhibitor of EWS-FLI1 in early clinical development, for the treatment of Ewing Sarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 694. doi:10.1158/1538-7445.AM2017-694
Association between inflammatory mediators and angiographic morphologic features indicating thrombus formation in patients with acute myocardial infarction. (2009)

In patients with acute myocardial infarction, higher neutrophil counts, neutrophil/lymphocyte ratio, and levels of high-sensitivity C-reactive protein are predictors to indicate thrombus formation.
Overlap in disease concept of functional esophageal disorders and minor esophageal motility disorders (2019)

Minor esophageal motility disorders were frequently observed in FEDs, but the causal relationship between esophageal symptoms remains unclear. The disease concepts of FEDs and minor esophageal motility disorders are considered to overlap and are both independent of major esophageal motility disorders.
Trophic Factors in Neurologic Disease (1988)

Recent studies suggest that diffusible factors released by neural targets enhance the survival, growth, and differentiation of neurons both peripherally and in the central nervous system. Evidence for such trophic factors exists for many of the neural systems involved in the degenerative neurologic diseases Alzheimer's disease, parkinsonism, and amyotrophic lateral sclerosis. It is our hypothesis that for each of these disorders there is both a primary insult and a secondary effect. The primary insult may have multiple etiologies, but the secondary effect is the result of retrograde degeneration. Such retrograde degeneration occurs because of an impairment of trophic factor function or an inadequacy of trophic effects to keep pace with the primary destructive process. Accordingly, it may be possible to exploit such trophic mechanisms to define further the pathobiology of neural degeneration and to develop specific treatments for currently incurable illnesses.
Thermodynamique des porteurs de charges dans les verres à conduction ionique (1992)

Ionic conductivity in glasses is mainly cationic, singly charged cation leading to the highest conductivities. Despite a large variety of chemical compositions (oxide or chalcogenide glasses) and a very large spread for room temperature conductivity (over 6 orders of magnitude) all glasses present important similarities. Below their vitreous transition temperature Tg, ionic conductivity is an activated process [MATH] and isothermal conductivity variations with composition are mainly the result of the activation energy variations ([MATH]) since dl the extrapolated values of conductivity when T tends to infinity ([MATH]) are within only one or two orders of magnitude. This behaviour is explained assuming an ionic displacement due to interstitial pairs in very low concentration. Interstitial pairs formation and migration are activated mechanisms and both contribute to the measured activation energy for ionic conduction. The usual approach developed by physicists for defect formation in ionic crystals explains very simply the similar values obtained for [MATH] but not the [MATH] variations with composition. The dissociation theory, more familiar to chemists, completes this approach and links [MATH] and [MATH] to partial entropy and enthalpy of the alkali salts dissolved in the glassy matrix. From these relationships conductivity variations with composition or quenching rate are interpreted.
A baseline algorithm for estimating talker orientation using acoustical data from a large-aperture microphone array (2004)

We have shown that knowing the orientation of a talker in a large-aperture microphone array system can significantly improve location-estimation and beamforming algorithms. Measurements of a talker in an anechoic chamber have shown significant anisotropy in radiation patterns that may be used to influence the selection, processing, and weighting of microphone signals in such algorithms. We introduce a simple method for determining the orientation of a talker within a large focal area using only acoustic energy data obtained from the array. The mathematical basis for this procedure is presented and computed performance, based solely on acoustical measurements in a real environment, are listed and discussed.
<title>Rectangular pixel-based fractal diffraction patterns</title> (1995)

Fractals have been used successfully in generating missing information in scene reconstruction. If this information is processed using coherent optical techniques, then it is important to understand the properties of the Fourier transforms of fractals. Since fractals with square or rectangular bases are representative of pixel structures found on most electrically adressed spatial light modulators, a square-based fractal has been generated and its far field diffraction pattern calculated. The properties of the resulting Fourier spectrum are discussed.
Parametric Study and Improvement of Phase Separation in Intermediate Headers of Microchannel Condensers (2018)

Phase separation has been proven to be beneficial to air-cooled parallel flow microchannel condensers for air conditioning systems. The inlet to the condenser with phase separation is located at the middle of the condenser height. After the first pass, in the vertical second header of the condenser, vapor phase separates from liquid phase mainly due to gravitational effects. In ideal case vapor should go to the top exit and liquid to the bottom exit, resulting in increased heat transfer. Due to interaction between vapor and liquid, separation is not perfect, expressed through the separation efficiency. This paper presents a parametric study of phase separation efficiency in the intermediate headers, with the target to improve separation efficiency. Header prototypes which have two exits are made with transparent PVC to simulate the real header and provide visual access. Using R-134a as a baseline, the measurement of separation efficiency and its general trend will be shown first. The results are compared to those of a mechanistic model based on flow regime and force balance analysis. Inlet mass flux in simulation is controlled at 87 kg·m−2·s−1 – 311 kg·m−2·s−1 and inlet quality at 0.05–0.25. The observed flow patterns in header are compared with the modeling results as well. Then, the header diameter is increased, which effectively improves the separation efficiency due to reduction of vapor velocity in header. Finally, R245fa and R32 are modeled in comparison with R-134a to discuss the effect of fluid properties on separation efficiency.
Catalytic Asymmetric Synthesis of anti-1,2-Diols (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCatalytic Asymmetric Synthesis of anti-1,2-DiolsWolfgang Notz and Benjamin ListView Author Information The Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037 Cite this: J. Am. Chem. Soc. 2000, 122, 30, 7386–7387Publication Date (Web):July 14, 2000Publication History Received26 April 2000Revised16 June 2000Published online14 July 2000Published inissue 1 August 2000https://pubs.acs.org/doi/10.1021/ja001460vhttps://doi.org/10.1021/ja001460vrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views11164Altmetric-Citations603LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aldehydes,Aldol reactions,Diols,Molecular structure,Stereoselectivity Get e-Alerts
Multi-scale retinex for color image enhancement (2002)

The retinex is a human perception-based image processing algorithm which provides color constancy and dynamic range compression. We have previously reported on a single-scale retinex (SSR) and shown that it can either achieve color/lightness rendition or dynamic range compression, but not both simultaneously. We now present a multi-scale retinex (MSR) which overcomes this limitation for most scenes. Both color rendition and dynamic range compression are successfully accomplished except for some "pathological" scenes that have very strong spectral characteristics in a single band.
Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes (2001)

The cyclin-dependent kinase inhibitor p21(Waf-1/Cip-1) is expressed at high level during megakaryocyte differentiation, but its precise function remains unknown. In this study, it is confirmed that p21 was expressed at a high level in hypoploid (2N and 4N) and polyploid (at least 8N) human megakaryocytes derived from CD34(+) cells. A high expression of p27(Kip1), p16, cyclin E, and cyclin D3 was also found in both populations associated with a hypophosphorylated form of retinoblastoma protein, suggesting that the majority of hypoploid and polyploid megakaryocytes are G(1)-arrested cells. As human megakaryocytes grown in vitro present a defect in their polyploidization, the study switched to the murine model. The modal ploidy of megakaryocytes derived from lineage-negative cells was 32N, and an elevated expression of p21 was found in high-ploidy megakaryocytes. In addition, p21 and p27 were coexpressed in the majority of mature polyploid megakaryocytes. The p21 was detected by immunofluorescence in megakaryocytes derived from p53(-/-) mice, demonstrating a p53-independent regulation during megakaryocyte differentiation. Megakaryocytopoiesis of p21(-/-) mice was subsequently studied. No marked abnormality in the ploidy of primary or cultured megakaryocytes was detected. Overexpression of p21 in p21(-/-) or normal murine megakaryocytes and in human megakaryocytes showed in all these cases a marked inhibition in megakaryocyte polyploidization. In conclusion, while a reciprocal relation is observed between p21 levels in megakaryocytes and the cycling state of the cells, p21 is not essential for the determination of the ploidy profile in normal megakaryocytes in vivo. However, high levels of its expression in cultured megakaryocytes arrest the endomitotic cell cycle.
On hypotheses testing for ergodic processes (2008)

We address three problems of statistical analysis of time series: goodness-of-fit (or identity) testing, process discrimination, and the change point problem. For each of the problems we construct a test that is asymptotically accurate for the case when the data is generated by stationary ergodic processes. All problems are solved in a similar way by using empirical estimates of the distributional distance between the processes.
Prevalence and clinical correlates of right ventricular hypertrophy in essential hypertension (2009)

RVH is commonly found in systemic hypertension and is associated with LVH (i.e., biventricular hypertrophy) in approximately one-fifth of the patients seen in a specialist setting. The clinical correlates of biventricular hypertrophy suggest that this phenotype is associated with a profile of very high cardiovascular risk.
Textbook of Metallic Stents (1997)

1. Arterial Stenting 2. Venous 3. Tips 4. Arterial Stent Grafting 5. Oesophageal Stents 6. Biliary Metallic Stents 7. Tracheo-Bronchial Stenting 8. Metallic Stents in the Urinary Tract 9. The Biological Effects of Metallic Stents 10. Carotid Stenting 11. Description, Intrinsic Properties and Characteristics of the Strecker Stent 12. Review of all Stents
Hydroacylation carbonylante d'alcynes : nouvelle voie d'accès à des cétones alpha, béta-insaturées (2008)

Du fait de leur difonctionnalites et, donc, de par leur reactivite particuliere, les cetones alpha,beta-insaturees interviennent dans de nombreux schemas de synthese de molecules complexes et le developpement de nouvelles voies pour leur preparation est donc d'une grande importance. Ce travail consiste a developper la reaction d'hydroacylation carbonylante d'alcynes pour la synthese d'enones. L'optimisation et le developpement de ce systeme en utilisant les alcynes tenninaux simples a permis d'obtenir divers enones avec de bons resultats. De plus, l'application de la reaction a des alcynes particuliers, notmmnent les alcools propargyliques, a permis l'acces a des furanes. L'etude du mecanisme de la reaction a aussi ete entrepris avec l'utilisation d'outils analytiques et, plus particulierement, la RMN sous pression de monoxyde de carbone. Cette etude a permis de recueillir des informations quant au cycle catalytique engage dans cette transformation.