gebhart/patrepeval huggingface dataset:
Differential Regulation of <i>Toll-Like Receptor 4</i> Gene Expression in Renal Cells by Angiotensin II: Dependency on AP1 and PU.1 Transcriptional Sites (2007)

ANG II stimulates TLR4 transcription through AP1 and PU.1 sites in a cell-specific manner. Since the intrarenal ANG II concentrations are enhanced in many pathophysiological situations, ANG-II-stimulated transcription of TLR4 on MMCs and podocytes may contribute to renal inflammation.
Évaluation de l’impact de caches pour de la vidéo adaptative par satellite (2018)

International audience
Multiple frequency resolution using stressed liquid crystal as a Fourier transform spectrometer (2009)

Stressed liquid crystals are tested with two-wavelength sources and varying intensity inputs in order to further examine their functionality as phase modulating elements in Fourier transform spectroscopy.
IMPROVEMENT OF THE STRUCTURAL LAYOUT OF POTATO PLANTERS’ COULTER GROUP (2021)

Structural layouts of coulters and their groups in potato planters are justified in the article based on the morphological features of the potato plant, its requirements for growing conditions and ensuring the quality of the planting process. The purpose of coulter groups is to form a bed for placing tubers with a loose layer of soil in 5-8 cm and sealing them with loosened soil to a certain depth. To substantiate the type of potato planter coulters that meet the requirements for potato growing conditions to the maximum extent possible, optimize the parameters of coulter groups that automatically ensure the stability of the coulter travel depth when imitating irregularities of the field microrelief. A comparative analysis of the impact on the soil of the most common anchor coulters with a blunt angle of soil entry and a sharp angle with an individual floating suspension is given, and indicators of the quality of their operation are described. It was found that coulters with an individual floating suspension and an acute angle of soil entry meet the requirements for potato growing conditions to the maximum extent possible. In order to ensure travel stabilization of such a coulter at a given depth when imitating field irregularities, a version of the coulter group has been developed that provides automatic correction of the coulter's angle of attack when changing its travel depth. Experimental studies have optimized the parameters of the coulter suspension that ensure automatic imitation of field microrelief irregularities up to 20 cm deep within the initial requirements for potato planting machines. Coulters with an individual floating suspension and a sharp angle of soil entry most fully meet the requirements for potato growing conditions to the maximum extent possible. A coulter group with a suspension aspect ratio of 150:200:400:400 cm and an acute angle of coulter entry into the soil provides automatic maintenance of the set coulter travel depth within the initial requirements (±2 cm) for irregularities in the field microrelief of up to 200 mm. In this case, the bottom and walls of the furrow are not compacted.
Eddy current analysis of three-phase transformer using 3-D parallel finite element method (2016)

We analyzed the electromagnetic field of a three-phase transformer using the three-dimensional parallel finite element method. The time variations of the flux and eddy current distributions of the transformer are clarified in detail. It is also clarified that the eddy current loss of the transformer is affected by the build-up method of the laminated steel sheets.
A taxonomy for swarm robots (2002)

In many cases several mobile robots (autonomous agents) can be used together to accomplish tasks that would be either more difficult or impossible for a robot acting alone. Many different models have been suggested for the makeup of such collections of robots. In this paper the authors present a taxonomy of the different ways in which such a collection of autonomous robotic agents can be structured. It is shown that certain swarms provide little or no advantage over having a single robot, while other swarms can obtain better than linear speedup over a single robot. There exist both trivial and non-trivial problems for which a swarm of robots can succeed where a single robot will fail. Swarms are more than just networks of independent processors - they are potentially reconfigurable networks of communicating agents capable of coordinated sensing and interaction with the environment.
[Vdot]O2Max in Variable Type Exercise Among Well-Trained Upper Body Athletes (1982)

Abstract The purpose of this study was to determine the maximal oxygen consumption ([Vdot]O2 max) of well-trained upper body (WTUB) athletes and untrained individuals in four different types of exercise: arm cranking (AC), legs only cycling (LC), graded treadmill running (TM) and combined arm cranking and leg cycling (A + L). The subjects included 12 rowers, 10 gymnasts, 11 swimmers, 10 wrestlers and 12 non-WTUB individuals. Maximal oxygen uptake was measured via an open circuit system. The results of this study indicated that: (1) WTUB athletes attained a significantly (p<.05) higher [Vdot]O2 max in AC and A + L than non-WTUB individuals, (2) differences among various WTUB groups in AC were reduced when [Vdot]O2 max was expressed in ml · kg-1 · min-1, but became evident in A + L, (3) WTUB athletes attained 80–95% of their LC [Vdot]O2 max in AC whereas non-WTUB individuals attained 60-70%, (4) WTUB individuals attained 120-130% of their LC [Vdot]O2 max in A + L whereas non-WTUB individuals attained 110-115%, and (5) non-WTUB individuals attained their highest [Vdot]O2 max in TM whereas WTUB athletes attained equivalent values in TM and A + L. It was concluded that WTUB athletes attained a higher [Vdot]O2 max than non-WTUB individuals in exercise involving the upper body musculature. Differences in upper body aerobic capacity among the variously trained WTUB groups were more apparent under the acute stress of A + L than in AC alone. TM appeared to be the most appropriate mode of exercise for eliciting [Vdot]O2 max in non-WTUB individuals. However, TM and A + L were equally effective in eliciting [Vdot]O2 max in WTUB athletes. Key Words: [Vdot]O2 maxathletesarm and leg worktraining specificity
Detailed genotyping demonstrates association between the slow acetylator genotype for N-Acetyltransferase 2 (NAT2) and familial parkinson's disease (2000)

In a preliminary report we demonstrated an association between the slow acetylator genotype of N-acetyltransferase 2 (NAT2) and familial cases of Parkinson's disease (FPD). Using a considerably more precise NAT2 typing method, which detects all mutant NAT2 alleles with a frequency of >1% in the white population, we have now retyped all the original patients and control subjects to investigate the reliability of our initial findings. The slow acetylator genotype remained considerably more common among FPD (73%) than normal control subjects (NPC, 43%) or the disease (Huntington's disease [HD]) control group (52%) with an odds ratio (OR) of 3.58 (95% confidence interval (CI): 1.96-6.56; p = 0.00003) for FPD versus NPC and an OR of 2.50 (95% CI: 1.37-4.56, p = 0.003) for FPD versus HD. Furthermore, the wild-type allele 4 conferred a protective effect with an OR of 0.39 (95% CI: 0.23-0.64; p = 0.0025) for FPD versus NPC and an OR of 0.50 (95% CI: 0.30-0.85, p = 0.01) for FPD versus HD. The results of this study support an association between the NAT2 slow acetylator genotype and FPD in our population.
Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: Effect of simvastatin (2008)

Prostacyclin (PGI2) is an important regulator of vascular homeostasis. Our goal was to analyze the role of sphingosine 1-phosphate (S1P) and its receptors in the up-regulation of cyclooxygenase-2 (Cox-2) induced by HDL in human vascular smooth muscle cells (VSMC). S1P induces Cox-2 expression in a time-and dose-dependent manner at concentrations (0.02-1 microM) compatible with those present in physiological HDL levels. The effect was mimicked by dihydro-S1P (DhS1P), a S1P derivative that only acts through cell surface S1P receptors. Desensitization of S1P receptors with S1P (or DhS1P) abolished HDL-induced Cox-2 up-regulation and PGI2 release. Inhibition of S1P receptors by suramin (inhibitor of S1P3), JTE013 (inhibitor of S1P2) or VPC23019 (inhibitor of S1P1 and S1P3) reduced the up-regulation of Cox-2 induced by HDL and S1P. The combination of suramin and JTE013 increased the inhibitory effect compared to that observed in cells treated with each inhibitor alone. siRNA against S1P2 or S1P3 significantly reduced the ability of HDL and S1P to up-regulate Cox-2. Simvastatin induced over-expression of S1P3 and potentiated the induction of Cox-2 expression produced by HDL (or S1P). Finally, suramin, JTE013 and VPC23019 inhibited p38 MAPK and ERK1/2 signaling pathways activated by HDL (or S1P) and the downstream activation of CREB, a key transcription factor involved in Cox-2 transcriptional up-regulation. These results indicate that S1P receptors, in particular S1P2 and S1P3, are involved in the Cox-2-dependent effects of HDL on vascular cells. Strategies aimed to therapeutically modulate S1P or S1P receptors could be useful to improve cardiovascular protection.
ChemInform Abstract: Tuning the Reactivity of Mono‐ and Bimetallic Coordination and Organometallic Complexes (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Best Practice for Fiber Optic Leak Detection, Injection and Production Profiling (2020)

Summary Distributed Fiber Optic (DFO) sensing are being used in various degrees in the upstream oil and gas industry. Applications in domains like geophysics, production, and integrity and reservoir management are providing a much better understanding compared to more conventional data acquisition methods. With fiber optic sensing the user are able to receive information from the entire fiber optic cable simultaneously, revealing the dynamic variations across the entire wellbore. The most commonly DFO technology used is Distributed Temperature Sensing (DTS) and Distributed Acoustic Sensing (DAS). These sensing technologies requires a different approach in order to maximize the value of the output. This paper discusses the best practices for three different applications for the upstream fiber optic sensing with focus on designing a sensing program fit for purpose. The sensing program will have to be tailor-made towards these applications. This paper will introduce a set of guidelines to follow in order to ensure as good results as possible.
Fine-scale ecological and transcriptomic data reveal niche differentiation of an allopolyploid from diploid parents in Cardamine (2019)

Abstract Polyploidization, or whole genome duplication, is one of the major mechanisms of plant speciation. Allopolyploids (species that harbor polyploid genomes originating from hybridization of different diploid species) have been hypothesized to occupy a niche with intermediate, broader, or fluctuating environmental conditions compared with parental diploids. It remains unclear whether empirical data support this hypothesis and whether specialization of expression patterns of the homeologs (paralogous gene copies resulting from allopolyploidization) relates to habitat environments. Here, we studied the ecology and transcriptomics of a wild allopolyploid Cardamine flexuosa and its diploid parents C. hirsuta and C. amara at a fine geographical scale in their native area in Switzerland. We found that the diploid parents favored opposite extremes in terms of soil moisture, soil carbon-to-nitrogen ratios, and light availability. The habitat of the allopolyploid C. flexuosa was broader compared with those of its parental species and overlapped with those of the parents, but not at its extremes. In C. flexuosa , the genes related to water availability were overrepresented among those at both the expression level and the expression ratio of homeolog pairs, which varied among habitat environments. These findings provide empirical evidence for niche differentiation between an allopolyploid and its diploid parents at a fine scale, where both ecological and transcriptomic data indicated water availability to be the key environmental factor for niche differentiation. Significance statement Polyploidization, or whole genome duplication, is common in plants and may contribute to their ecological diversification. However, little is known about the niche differentiation of wild allopolyploids relative to their diploid parents and the gene expression patterns that may underlie such ecological divergence. We detected niche differentiation between the allopolyploid Cardamine flexuosa and its diploid parents C. amara and C. hirsuta along water availability gradient at a fine scale. The ecological differentiation was mirrored by the dynamic control of water availability-related gene expression patterns according to habitat environments. Thus, both ecological and transcriptomic data revealed niche differentiation between an allopolyploid species and its diploid parents.
'I am both here and there' Parallel Control of Multiple Robotic Avatars by Disabled Workers in a Café (2023)

Robotic avatars can help disabled people extend their reach in interacting with the world. Technological advances make it possible for individuals to embody multiple avatars simultaneously. However, existing studies have been limited to laboratory conditions and did not involve disabled participants. In this paper, we present a real-world implementation of a parallel control system allowing disabled workers in a café to embody multiple robotic avatars at the same time to carry out different tasks. Our data corpus comprises semi-structured interviews with workers, customer surveys, and videos of café operations. Results indicate that the system increases workers' agency, enabling them to better manage customer journeys. Parallel embodiment and transitions between avatars create multiple interaction loops where the links between disabled workers and customers remain consistent, but the intermediary avatar changes. Based on our observations, we theorize that disabled individuals possess specific competencies that increase their ability to manage multiple avatar bodies.
Thromboxane A2 synthetase inhibitors. I. Syntheses and activities of various N-heteroaromatic derivatives. (1988)

Basic N-heteroaromatic derivatives (1, 2, 4-triazole, thiazole and pyrimidine derivatives) having a 2-[4-(carboxy)phenoxy]ethyl moiety or a 4-[2-(carboxy)vinyl]benzyl moiety were prepared, and evaluated for ability to inhibit thromboxane A2 (TXA2) synthesis. Among the compounds prepared in this study, the 5-substituted thiazole derivatives 14d, 27 and 28 were more potent inhibitors of TXA2 production than the corresponding imidazole derivatives, and the 1-substituted 1H-1, 2, 4-triazole derivatives 14a and 15a were almost as potent as the corresponding imidazole derivatives.
Electrochemical Studies on the Competition Between Intramolecular Electron Transfer and Intermolecular Protonation of Nitroaryl Radical Anions in the Reductions of Apical Carboxylic Acid Substituents of 2- and 3-Nitro- 9,10-dihydro-9,10-ethanoanthracene-9-carboxylic Acids (1997)

The results obtained from variable scan rate cyclic voltammetry (c.v.) on 2-nitro- and 3-nitro-9,10- dihydro-9,10-ethanoanthracene-9-carboxylic acids [(4) and (5), respectively], combined with simulations of various c.v. responses, are consistent with reduction of a benzylic acid group being facilitated by an intramolecular electron transfer process. This intramolecular process involves a one-electron reduction of the nitroaromatic group, followed by a rapid and irreversible p*(ArNO2)•- ? p*(RCO2H)•- intramolecular electron transfer to the carboxylic acid group at a benzylic bridgehead position of the acids (4) and (5). The reduction potentials of the acid groups are shifted more than 0·3 V to positive potentials at slow scan rates (20-100 mV s-1) compared with the unnitrated acid derivative (6). The reduction potentials and the relative peak currents for the reductions of the nitro and acid groups for each of compounds (4) and (5) are dependent on the concentrations of the reactants. At concentrations of substrate &amp;gt;1 mM, reduction of the acid moiety is increasingly dependent on complex intermolecular processes. These intermolecular processes compete with intramolecular electron transfer from the nitroaryl anion to the apical acid group at the benzylic bridgehead position. Digital simulations of the voltammetric data were confined to substrate concentrations &amp;lt;1 mM, and show that the intramolecular reductions of the apical carboxylic acid protons of (4) and (5) are complicated by competing intermolecular electron transfer and intermolecular self-protonations of the nitro radical anions. The value of the intramolecular electron transfer rate constant for the meta compound is an order of magnitude larger than that for the para compound, which is the opposite reactivity pattern to that generally found in the S RN1 reactions of m - and p -nitrobenzyl halides. This indicates that there is likely to be an important contribution from an intramolecular through-space electron transfer mechanism for the former reaction
Single chip solution to capacitive liquid crystal chemical and biological sensor (2011)

In this paper a CMOS single chip capacitive liquid crystal chemical and biological sensor is presented. Two on-chip interdigitated capacitors provide differential sensor measurement. The system consists of a low noise preamplifier, synchronous demodulator and low pass filter. For high sensitivity detection proper excitation signal voltage and frequency have been investigated and the preamplifier noise has been minimized using a nonlinear optimization algorithm. To the knowledge of the authors this is the first integrated capacitive liquid crystal chemical and biological sensor chip. The amplifier has 15aF resolution with 1kHz bandwidth and consumes 1mW of power and 0.4mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of chip area using AMI 0.5μm technology.
Genetic relations between the central and southern Philippine Trench and the Sangihe Trench (1998)

International audience
Plasma fibrinogen and wall thickness in carotid and female arteries: findings from the KIHD study (1997)

http://deepblue.lib.umich.edu/bitstream/2027.42/51554/1/Salonen JT, Plasma fibrinogen and wall thickness in carotid, 1997.pdf
Autoimmune Response to IGF2 mRNA‐Binding Protein 2 (IMP2/p62) in Breast Cancer (2015)

The purpose of this study was to understand the autoimmune response and immunogenicity of a tumour-associated antigen IMP2/p62 in breast cancer. Autoantibody responses to IMP2/p62 were evaluated by enzyme-linked immunosorbent assay (ELISA), Western blotting and indirect immunofluorescence assay in sera from patients with breast cancer, benign breast tumour and normal human individuals. Immunohistochemistry (IHC) study with breast cancer tissues was also performed to analyse protein expression of IMP2/p62. The results have demonstrated that IMP2/p62 can induce a relatively higher frequency of autoantibody response in breast cancer (14.3%, 7/49) compared to patients with benign breast tumour (5.6%, 2/36) and normal individuals (2.2%, 1/44). The frequency of IMP2/p62 expression in breast cancer tissues was significantly higher than that in normal tissues (P < 0.01). The data suggest that autoantibody against IMP2/p62 may be a useful serum biomarker for early-stage breast cancer screening and diagnosis.
Experimental analysis of cross-talk effects between a series of nano-hole structures on the same metal film (2011)

The miniaturization of nanostructure-based optical sensing devices requires integration of multiple nanostructure patterns with smaller spacing. However, the effect of plasmonic cross-talk and its effect on spectral transmission are not fully understood. In this paper, we experimentally fabricated different sets of nano-hole arrays (each with an area of 30 &mu;m x 30 &mu;m) of various hole diameter, hole spacing, and inter-array spacing. The spectral transmission of each nano-hole array was measured and the effect of inter-array spacing on peak transmission and resonance wavelength was determined.
Mutation ofCEBPAin Familial Acute Myeloid Leukemia (2004)

We describe a family in whom three members affected by acute myeloid leukemia (AML) had an identical, 212delC mutation in CEBPA, the gene encoding the granulocytic differentiation factor C/EBPalpha. Unaffected family members did not have this mutation. Latent periods of 10, 18, and 30 years elapsed before the onset of overt leukemia in the three patients. One of them had a second CEBPA mutation, but only at the time of diagnosis. All three patients are currently well, with no abnormalities in the bone marrow. CEBPA mutation is apparently the primary event in the development of AML in this family.
Candida albicans and Bacterial Microbiota Interactions in the Cecum during Recolonization following Broad-Spectrum Antibiotic Therapy (2012)

Candida albicans is a normal member of the gastrointestinal (GI) tract microbiota of healthy humans, but during host immunosuppression or alterations in the bacterial microbiota, C. albicans can disseminate and cause life-threatening illness. The bacterial microbiome of the GI tract, including lactic acid bacteria (LAB), plays a vital role in preventing fungal invasion. However, little is known about the role of C. albicans in shaping the bacterial microbiota during antibiotic recovery. We investigated the fungal burdens in the GI tracts of germfree mice and mice with a disturbed microbiome to demonstrate the role of the microbiota in preventing C. albicans colonization. Histological analysis demonstrated that colonization with C. albicans during antibiotic treatment does not trigger overt inflammation in the murine cecum. Bacterial diversity is reduced long term following cefoperazone treatment, but the presence of C. albicans during antibiotic recovery promoted the recovery of bacterial diversity. Cefoperazone diminishes Bacteroidetes populations long term in the ceca of mice, but the presence of C. albicans during cefoperazone recovery promoted Bacteroidetes population recovery. However, the presence of C. albicans resulted in a long-term reduction in Lactobacillus spp. and promoted Enterococcus faecalis populations. Previous studies have focused on the ability of bacteria to alter C. albicans; this study addresses the ability of C. albicans to alter the bacterial microbiota during nonpathogenic colonization.