gebhart/patrepeval huggingface dataset:
Neutrophil-elastase in chronic inflammatory bowel disease: a marker of disease activity? (1999)

We conclude that plasma elastase is a useful independent marker of disease activity in inflammatory bowel disease. Especially for identifying patients in remission, the measurements of elastase seem to be more suitable than other parameters of inflammation, like CRP or ESR.
Reactivity-Initiated-Accident Analysis without Scram of a Molten Salt Reactor (2008)

Recently, a conceptual design of a small MSR, named FUJI-12 has been proposed. FUJI-12 operates with the same fuel salt as the Molten Salt Breeder Reactor (MSBR) designed by ORNL. The authors are interested in the MSR concept due to its high potential in the areas of safety, proliferation resistance, resource sustainability and waste reduction, all necessary requirements for the generation IV nuclear power systems. The authors believe that additional investigations are necessary for future study. From this point of view, the authors have analyzed various reactivity insertion accidents due to control rod malfunctions in FUJI-12. The MSR can be operated with a small excess reactivity. However, at the same time, the delayed neutron fraction is quite small due to the usage of U-233 as fissile material and the circulation of the fuel salt. Therefore, the reactivity insertion accident should be qualitatively evaluated. The reactor transients were analyzed without scram in order to evaluate the severity of such accidents against the safety. Although the total primary system design of FUJI-12 is not completed, and thus, the accident analyses include some crude assumptions, it can be expected that the reactivity insertion accident in FUJI-12 would not result in severe plant conditions.
Options for the generation of seedless cherry, the ultimate snacking product (2022)

This manuscript identifies cherry orthologues of genes implicated in the development of pericarpic fruit and pinpoints potential options and restrictions in the use of these targets for commercial exploitation of parthenocarpic cherry fruit. Cherry fruit contain a large stone and seed, making processing of the fruit laborious and consumption by the consumer challenging, inconvenient to eat 'on the move' and potentially dangerous for children. Availability of fruit lacking the stone and seed would be potentially transformative for the cherry industry, since such fruit would be easier to process and would increase consumer demand because of the potential reduction in costs. This review will explore the background of seedless fruit, in the context of the ambition to produce the first seedless cherry, carry out an in-depth analysis of the current literature around parthenocarpy in fruit, and discuss the available technology and potential for producing seedless cherry fruit as an 'ultimate snacking product' for the twenty-first century.
Transduction of Liver Metastases After Intravenous Injection of Ad5/35 or Ad35 Vectors With and Without Factor X-Binding Protein Pretreatment (2009)

Inefficient tumor transduction with targeted adenoviral vectors is largely due to unspecific virus sequestration by blood components, including coagulation factor X, and Kupffer cell scavenging. In this study, we show that preinjection of snake venom factor X-binding protein (X-bp) reduces hepatocyte transduction and increases the circulation time in blood of an intravenously injected, fiber-chimeric Ad5/35 vector. X-bp pretreatment resulted in improved Ad5/35 transduction of liver metastases and increased the antitumor efficacy of an Ad5/35-based oncolytic adenovirus. Furthermore, we demonstrate that a vector based on adenoviral serotype 35, which is less sequestered by factor X, is efficient in tumor targeting. This gives a rationale for using Ad35-based vectors in virotherapy of cancer.
Effect of Neosaxitoxin on Epidural Anesthesia in Cats: a Promising Alternative to Conventional Anesthetics (2019)

Neosaxitoxin (NeoSTX) is a specific high-affinity inhibitor of voltage-dependent sodium channels, which has shown excellent results as a local anesthetic in various pathologies and post-operative protocols, since it effect is long-lasting and have virtually no side effects.The aim of this study was to analyze the effect of NeoSTX as an epidural anesthetic in female cats, undergoing ovariohysterectomy, compared to Lidocaine in a randomized and double-blind study. Two groups of 11 female cats were randomly in the NeoSTX group and the lidocaine group. They were administered, respectively, a single dose of NeoSTX (0.5 μg / kg) or lidocaine (4 mg / kg, 2%) by epidural via. Using the UNESP-Botucatu pain assessment scale, which considers multiple behavioral and physiological factors, the epidural anesthetic effect of NeoSTX and lidocaine was evaluated, up to 240 min after the ovariohysterectomy procedure. NeoSTX no altered the peripheral blood pressure during the cut of uterine cervix, and generated lower values on the pain scale as compared to the lidocaine treatment. None of the cats anesthetized with NeoSTX required an extra dose of pain-relieving drugs (2 mg / kg of tramadol) during the first 150 min after surgery, whereas nine cats from the lidocaine group did need an extra dose of analgesic. NeoSTX is a powerful pain blocker, with a long-lasting anesthetic effect when administered by an epidural procedure. Therefore, NeoSTX emerges as a promising alternative to conventional anesthetics for the treatment of postoperative pain.
Determination of Peptization Time of Particulate Sols Using Optical Techniques: Titania As a Case Study (2008)

Colloidal sol−gel technology is widely used as a powerful synthesis route. It consists of two main stages, hydrolysis and peptization. The quantification of peptization time is necessary to improve the processing control and enhance product reliability. However, the peptization time is normally estimated by simple visual inspection. The aim of this work is to establish for the first time a procedure to quantify the peptization time. For such purposes, different optical techniques have been used, in particular the measurements of particle size distribution by laser diffraction and by dynamic light scattering. The experimental mismatch between both series of data allows determining the peptization time, and the results are in good agreement with turbidimetry measurements through the transmission of near-infrared light source. The synthesis of titania has been selected as a case study because anatase presents a large interest in many different applications. It has been demonstrated that peptization time significantly increases as the synthesis temperature decreases: Sols prepared at 25 °C present a peptization time of ∼95 h, sols prepared at 30 °C need ∼72 h for a complete peptization, sols synthesized at 35 °C present a peptization time of ∼45 h, and those prepared at 50 °C show a peptization time of ∼9 h. The peptization time for sols prepared above 80 °C is quite short; the synthesis is less reproducible and the risk of uncontrolled gelation increases. The average particle size changes from ∼13 nm for sols prepared at 25 °C, 20 nm for sols prepared at 35 °C and, to ∼30 nm for sols prepared at 50 °C. The resulting xerogel has been characterized in order to demonstrate the suitability of the synthesis procedure.
Passband broadening of integrated arrayed waveguidefiltersusing multimode interference couplers (1996)

Passband broadening of arrayed waveguide filters that are compatible with singlemode fibre is demonstrated using an integrated multimode interference coupler at the entrance to the star coupler. An 8 × 1.6 nm filter is realised for the 1.55 µm band with 0.75 nm-wide –1 dB passbands and –20 dB rejection at &gt;1.7 nm bandwidth.
Role of lattice discreteness on brittle fracture: Atomistic simulations versus analytical models (2006)

By means of thorough atomistic simulations an energy-based theory, named quantized fracture mechanics, is commented and validated. This approach modifies continuum linear elastic fracture mechanics by introducing the hypothesis of discrete crack propagation, taking into account the discreteness of the crystal lattice. We investigate at an atomistic level the crack energy resistance for a matrix of silicon carbide with an isolated crack, and the effect on the stress at the crack tip due to a second phase particle. In both cases our results show that, while atomistic simulations provide the most basic level of understanding of mechanical behavior in nanostructured brittle materials, quantized fracture mechanics is able to effectively incorporate the main lattice-related feature, thus enlarging the realm of continuum modeling.
A robust 2.4 GHz time-of-arrival based ranging system with sub-meter accuracy: feasibility study and realization of low power CMOS receiver (2012)

Draadloze sensornetwerken worden meer en meer aangewend om verschillende soorten informatie te verzamelen. De locatie, waar deze informatie verzameld is, is een belangerijke eigenschap en voor sommige toepassingen, zoals het volgen van personen of goederen, zelfs de meest belangrijke en mogelijkmakende factor. Om de positie van een sensor te bepalen, is een technologie nodig die de afstand tot een gekend referentiepunt schat. Door verschillende afstandsmetingen te combineren, is het mogelijk de absolute locatie van de node te berekenen.
The Chemistry of Formazans and Tetrazolium Salts (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleThe Chemistry of Formazans and Tetrazolium SaltsA. W. NinehamCite this: Chem. Rev. 1955, 55, 2, 355–483Publication Date (Print):April 1, 1955Publication History Published online1 May 2002Published inissue 1 April 1955https://pubs.acs.org/doi/10.1021/cr50002a004https://doi.org/10.1021/cr50002a004research-articleACS PublicationsRequest reuse permissionsArticle Views1911Altmetric-Citations254LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Superparamagnetic nanoparticles in lymphatic tissue - Detection and distribution in a breast cancer model for magnetic particle imaging (2013)

The SPIOs are moving from the injection site through the lymph-fat tissue to the axillary region and finally into the axillary lymph nodes. SPIOs follows the traces of lymphatic vessels, respecting the borders and spaces between different tissues. They were found in the neighborhood of collagen fibers and accumulates in distinct regions. We present first results of the approach of SNLB with MPI.
Editorial: Dietary Lipid Absorption (2009)

The composition of dietary fat influences tissue fatty acid composition, which in turn impacts cellular function through a number of different processes. This includes changes in signaling, lipid metabolism, and transcriptional activities that normally function to maintain intracellular fatty acid homeostasis. The consumption of high levels of dietary fat in excess of caloric expenditure is linked with obesity and the disruption of normal homeostatic mechanisms governing lipid metabolism. Data from the Centers for Disease Control and Prevention show that obesity (defined as a BMI≥30) represents a considerable health concern in the United States. Of particular note is that for adult men, the prevalence of obesity was 33% in 2006; the prevalence for adult women was slightly higher at 35%. Obesity is also of concern for children and adolescents where in 2006, 16% were considered obese (above the 95th percentile of the 2000 BMI-for-age growth charts). Statistics released by the American Heart Association show that the rise in obesity correlates with high low-density lipoprotein-cholesterol (LDL-C) levels. In 2004, nearly 33% of adults in the United States (age 20 and older) had LDL-C levels of 130 mg/dL or higher. Obesity is associated with disturbances in lipid metabolism including triglycerides, free fatty acids and lipoprotein cholesterol. One common finding in obese individuals is elevated levels of circulating free fatty acids that in turn increases fatty acid internalization and ectopic accumulation of triglycerides. Such disturbances in normal lipid metabolic homeostasis are associated with changes in fatty acid oxidation, accumulation of reactive oxygen species, the synthesis of ceramide and ER stress. The correlation between chronically elevated plasma free fatty acids and triglycerides and low highdensity lipoprotein-cholesterol (HDL-C) levels with the development of obesity, insulin resistance and cardiovascular disease has led to the hypothesis that decreases in pancreatic insulin production, cardiac failure, arrhythmias, and hypertrophy are due to aberrant accumulation of lipids in these tissues. This Special Issue of Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, with a focus on dietary lipid absorption, is particularly timely given the obesity epidemic and comes from many of the leading experts in fatty acid and sterol transport. These review articles cover five general areas: [1] Fatty acid transport, with a focus on fatty acid translocase (CD36) and members of the fatty acid transport protein (FATP) family; [2] sterol transport, with a focus on Niemann-Pick C1-Like 1 (NPC1L1) and ATP binding cassette transporters G5 and G8 (ABCG5/ABCG8); [3] intracellular fatty acid trafficking, with a specific focus on liver fatty acid binding protein (L-FABP); [4] therapeutic properties of n-3 polyunsaturated fatty acids; and [5] chylomicron synthesis with a focus on regulation and the role of apolipoproteins.
Investigation of Factors Influencing Recombinant Human BMP2 Expression in Mammalian cells (2016)

S.1399
Rising Food Price, Asset Transfers, and Household Food Security (2015)

We study the role of food price rising and income generating assets as determinants of household food insecurity among the extreme poor in rural Bangladesh for the period 2002-2011. We do so in the context of an anti-poverty program, targeting the ultra-poor (TUP), which transferred productive livestock assets to the very poor. We find a positive significant impact of the asset transfers on household’s food security irrespective of whether we use subjective or objective measures of food security. Most importantly we find that the long-term impact of the program (estimated over 2002-2011) is smaller compared to mid-term (2002-2008) and short-term (2002-2005) impacts for all the indicators. We test whether this declining program impact is driven by the steep rise in food prices in the post-2007 period. We find that in the pre-crisis period participant households benefited while in the post crisis period they affected negatively by the price shock. This result explains the declining effect of TUP program. Our analysis therefore illustrates how the external shocks can undermine the effectiveness of an otherwise well-functioning anti-poverty program.
Conjugated Polymers as Efficient Fluorescence Quenchers and Their Applications for Bioassays (2002)

We have developed a novel approach for simple and convenient detection of ligand−receptor interactions with high sensitivity and selectivity. The method harnesses a reversible fluorescence quenching between nonfluorescent polyelectrolyte quenchers and fluorescent probes tagged to ligands. Formation of more strongly bound ligand−receptor complexes forces the breakup of nonspecific, electrostatic interaction-based quencher/probe pairs to reverse the fluorescence quenching, triggering a fluorescence increase, and providing an off-to-on detection of the ligand/receptor interaction. Although a conjugated polyelectrolyte was used in the study, other nonconjugated polyelectrolyte quenchers are expected to work as well. The method should potentially find a wide variety of applications in several areas, ranging from drug screening, medical diagnostics, and biosensing to assay development.
Synthesis of Alicyclic Diamines1 (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Alicyclic Diamines1L. C. Behr, J. E. Kirby, R. N. MacDonald, and C. W. ToddCite this: J. Am. Chem. Soc. 1946, 68, 7, 1296–1297Publication Date (Print):July 1, 1946Publication History Published online1 May 2002Published inissue 1 July 1946https://pubs.acs.org/doi/10.1021/ja01211a053https://doi.org/10.1021/ja01211a053research-articleACS PublicationsRequest reuse permissionsArticle Views265Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improvement on CAE Model for Accurate Torsional Springback Prediction in High Strength Steel Part Forming (2012)

It is difficult to predict springback, torsion in particular, with great accuracy by FE simulation. In this study, the effects of anisotropic yield functions of the blank and elastic deformation of the tools on springback are investigated in order to improve the accuracy of torsional springback prediction in high strength steel part forming. The effects of anisotropic yield functions on the torsional springback in curved hat forming were compared, using parameter sets derived from various experimental methods: uniaxial tensile tests only; hydrostatic bulge tests and uniaxial tension tests; uniaxial and biaxial tensile tests. FE analysis of press forming taking account of tool deformations was carried out and the results were compared with the ones of FE simulation with rigid tools and experimental results. It is demonstrated that FE simulated torsional springback with deformable tool model has better correlation with experimental one than with rigid tool model.
High-throughput mass spectrometry maps the sepsis plasma proteome and differences in response (2022)

Summary Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is an unmet global health challenge. Here we apply high-throughput tandem mass spectrometry to delineate the plasma proteome for sepsis and comparator groups (non-infected critical illness, post-operative inflammation and healthy volunteers) involving 2622 samples and 4553 liquid chromatography-mass spectrometry analyses in a single batch, at 100 samples/day. We show how this scale of data can establish shared and specific proteins, pathways and co-expression modules in sepsis, and be integrated with paired leukocyte transcriptomic data (n=837 samples) using matrix decomposition. We map the landscape of the host response in sepsis including changes over time, and identify features relating to etiology, clinical phenotypes and severity. This work reveals novel subphenotypes informative for sepsis response state, disease processes and outcome, highlights potential biomarkers, pathways and processes for drug targets, and advances a systems-based precision medicine approach to sepsis.
Mechanism of Charge Retention Loss in Ferroelectric Pt/Pb(Zr,Ti)O3/Pt Capacitors and Its Relation to Fatigue and Imprint (2003)

Abstract Charge retention loss was investigated for Pt/Pb(Zr0.4Ti0.6)O3/Pt capacitors in short- (t < 1 s) and long-time (t > 1 s) regimes. The short-time retention loss behaviors of fatigued capacitors were well described by a power-law function and analyzed in terms of a superposition of polarization relaxation with a distribution of relaxation time. We showed that depolarization field governs the retention loss in the short-time regime. Fatigue-induced defects, probably the interfacial passive layers, seemed to increase the depolarization field. In the long-time regime, the retention loss is shown to be related to the internal field developed parallel to the polarization direction. Particularly in "opposite-state" retention, the internal field caused polarization backswitching resulting in a severe degradation of retention characteristics. The internal field developed during retention was estimated by using Merz equations of polarization switching. Defects dynamics under electric field was discussed in conjunction with the recovery process of imprint. Keywords: FeRAM charge retention polarization dynamics fatigue imprint
2A1-E15 Distribution Shift and Task Allocation of Distributed Autonomous System by Double Repressing model (2009)

Honeybee which is social insect changes the work with age in day and does division of labor in a colony. A feature of this division is one of the suitability of creatures, a model of controlling juvenile hormone of honeybee which increases with age in day was proposed as a conventional research. In this model, there are 2 repressing effects for juvenile hormone, one is generated in inside, the other is generated when contact with other honeybees. But contact is not defined because this model is not considered about spatial relation. So we expand the model to be considered about contact on a colony, and define 2 task modes with hormone content for express division of labor. Next, we derive local and whole rates of division of labor in a colony by analyzing equilibrium conditions of the hormone equations. And we verify that these rates have stability for disturbance.
Analysis of Conditional Error Rate and Combining Schemes in HARQ (2012)

In hybrid automatic repeat request (HARQ), maximum ratio combining (MRC) is usually employed at the receiver if the retransmission signal is the same as that in the first transmission. However, conventional performance analysis of HARQ and MRC does not consider that all previous transmissions fail. In this paper, we analyze the conditional error rate of HARQ with arbitrary combining schemes. Both the theoretical and approximate expressions of the conditional error rate are derived. Our analytical and simulation results reveal that conventional MRC is not optimum for HARQ, especially when the packet is short or the channel gain of the first transmission is much better than that of retransmission.
Autosomal dominant limb-girdle muscular dystrophy (2001)

This family has a genetically distinct form of AD-LGMD. The authors are currently performing a genome-wide scan to identify the disease locus.