gebhart/patrepeval huggingface dataset:
An overlay network for replica placement within a P2P VoD network (2005)

Generic file sharing P2P applications have gained high popularity in the past few years. In particular, P2P streaming architectures have also attracted attention. Many of them consider many-to-one streaming or high-level multicast techniques. In contrast to these models, we propose techniques and algorithms for point-to-point streaming in autonomous systems as it might occur in large companies, a campus or even in large hotels. Our major aim is to create a replica situation that inter-subnetwork RSVP streams are reduced to a minimum. Therefore, we introduce the architecture of an overlay network for interconnecting subnetworks. Each subnetwork contains a so-called local active rendezvous server (LARS), which not only acts as directory server but also controls availability of movie content in its subnetwork. Owing to this, we consider data placement strategies depending on restrictions of network bandwidth, peer capabilities, as well as the movies' access frequency.
Kinematic Analysis of Experimentally Provoked Scoliosis in Pigs with Roentgen Stereophotogrammetry (1976)

A three-dimensional method to analyse the kinematics of the spine has been applied to four pigs with experimentally provoked scoliosis. The advantages and limitations of the method are discussed and some interesting facts concerning the provoked curves are emphasized.
Thyroid hormone-aldosterone interaction on Na+ transport in toad bladder (1979)

Repeated administration of thyroxine (T4) in vivo (2 microgram/100 g body wt for 6 days) lowered by 2.3 times (P less than 0.025, df = 18) the basal rate of Na+ transport measured by the short-circuit current (SCC) in vitro in the urinary bladder of the toad (Bufo marinus). This difference was not accounted for by a change in the plasma aldosterone concentration. Moreover the response of the SCC to aldosterone in vitro was markedly inhibited in bladders from T4-treated animals (P less than 0.001, df = 18). These findings raised the possibility of a direct interaction between thyroid hormone and aldosterone in the target cell. The effects of L-triiodothyronine (T3) and aldosterone were examined in vitro. T3 alone (60 nM) had no significant effect on the base-line SCC (deltamuA = -14 +/- 11 (SE) muA per hemibladder; P greater than 0.3, n = 10). By contrast, T3 (60 nM) inhibited the response of the SCC to aldosterone from 6 to 8 h after its addition (deltamuA = -98 +/- 19 muA per hemibladder; P less than 0.001, n = 10). The inhibition by T3 was present at 6 nM (P less than 0.01, n = 10) and became not significant at 0.6 nM. T3 had no significant effect on base-line or aldosterone-stimulated H+ transport. Thyroid hormone might therefore regulate the late response of the SCC to aldosterone at the level of its target cell.
The use of a nonlinear absorption model in the study of ascorbic acid bioavailability in man (1993)

A two-compartment disposition model of ascorbic acid (AA) pharmacokinetics with saturable and time-constrained intestinal absorption was developed. The model was fitted to pharmacokinetic data obtained after oral administration to nine healthy volunteers of two effervescent dosage forms differing in AA content: Celaskon 60 mg (CK60) and Celaskon 500 mg (CK500). It was demonstrated that in the case of CK500 less than 30% of the dose was absorbed as compared with CK60. Parameters of the AA nonlinear absorption kinetics were assessed by simultaneous fitting of mean concentration-time data for both doses and placebo. The relatively short duration of absorption found (3.2 h) can explain the failure of past attempts to increase the AA bioavailability using sustained-release dosage forms. Model simulation showed that the ingestion of 60 mg with 3-4 h intervals is optimal for maximal bioavailability of AA.
Digital integrated circuits : a design perspective (1996)

(NOTE: Each chapter begins with an Introduction and concludes with a Summary, To Probe Further, and Exercises and Design Problems.) I. THE FABRICS. 1. Introduction. A Historical Perspective. Issues in Digital Integrated Circuit Design. Quality Metrics of a Digital Design. 2. The Manufacturing Process. The CMOS Manufacturing Process. Design Rules-The Contract between Designer and Process Engineer. Packaging Integrated Circuits. Perspective-Trends in Process Technology. 3. The Devices. The Diode. The MOS(FET) Transistor. A Word on Process Variations. Perspective: Technology Scaling. 4. The Wire. A First Glance. Interconnect Parameters-Capitance, Resistance, and Inductance. Electrical Wire Models. SPICE Wire Models. Perspective: A Look into the Future. II. A CIRCUIT PERSPECTIVE. 5. The CMOS Inverter. The Static CMOS Inverter-An Intuitive Perspective. Evaluating the Robustness of the CMOS Inverter: The Static Behavior. Performance of CMOS Inverter: The Dynamic Behavior. Power, Energy, and Energy-Delay. Perspective: Technology Scaling and Its Impact on the Inverter Metrics. 6. Designing Combinational Logic Gates in CMOS. Static CMOS Design. Dynamic CMOS Design. How to Choose a Logic Style? Perspective: Gate Design in the Ultra Deep-Submicron Era. 7. Designing Sequential Logic Circuits. Timing Metrics for Sequential Circuits. Classification of Memory Elements. Static Latches and Registers. Dynamic Latches and Registers. Pulse Registers. Sense-Amplifier Based Registers. Pipelining: An Approach to Optimize Sequential Circuits. Non-Bistable Sequential Circuits. Perspective: Choosing a Clocking Strategy. III. A SYSTEM PERSPECTIVE. 8. Implementation Strategies for Digital ICS. From Custom to Semicustom and Structured-Array Design Approaches. Custom Circuit Design. Cell-Based Design Methodology. Array-Based Implementation Approaches. Perspective-The Implementation Platform of the Future. 9. Coping with Interconnect. Capacitive Parasitics. Resistive Parasitics. Inductive Parasitics. Advanced Interconnect Techniques. Perspective: Networks-on-a-Chip. 10. Timing Issues in Digital Circuits. Timing Classification of Digital Systems. Synchronous Design-An In-Depth Perspective. Self-Timed Circuit Design. Synchronizers and Arbiters. Clock Synthesis and Synchronization Using a Phased-Locked Loop. Future Directions and Perspectives. 11. Designing Arithmetic Building Blocks. Datapaths in Digital Processor Architectures. The Adder. The Multiplier. The Shifter. Other Arithmetic Operators. Power and Spped Trade-Offs in Datapath Structures. Perspective: Design as a Trade-off. 12. Designing Memory and Array Structures. The Memory Core. Memory Peripheral Circuitry. Memory Reliability and Yield. Power Dissipation in Memories. Case Studies in Memory Design. Perspective: Semiconductor Memory Trends and Evolutions. Problem Solutions. Index.
Three-Dimensional Nonlinear Dynamics of Nonintegral Riser Bundle (1991)

The dynamic behavior of a nonintegral riser bundle is studied parametrically. The dynamics of each component-riser is analyzed by a three-dimensional, nonlinear, large deflection, small strain model with coupled bending and torsion. Component-risers are slender, thin-walled, extensible or inextensible tubular beam-columns, subject to response and deformation dependent hydrodynamic loads. The con-nector equations of equilibrium are used to derive the connector forces and moments. Substructuring can thus be achieved even though in three dimensions connectors do not impose linearly dependent deflections at substructure interfaces. The developed time incremental and iterative finite-element computer code is used to analyze the effects of water depth, distribution of connectors, distance between component risers and number of finite elements in the numerical model. The problem of total CPU (central processor unit) time and the advantages of substructuring are discussed by running cases of up to 1094 degrees of freedom.
A newly developed dilution system for optical particle size and concentration measurements in oil-injected screw compressors (2023)

Oil mist coalescence separators are widely used downstream of screw compressors. Unfortunately, due to high concentration most of the available literature reporting particle sizes in raw or clean gas of screw compressors is on model systems at atmospheric pressure and room temperature. To study oil mist coalescence separators under real-world conditions, the pressurized aerosol needs to be diluted.
Ocular hypotensive effects of melatonin receptor agonists in the rabbit: further evidence for an MT3 receptor (2003)

(1) Melatonin is involved in the control of intraocular pressure during the night and day photoperiod. We have investigated the receptor that regulates intraocular pressure in New Zealand white rabbits by means of agonists and antagonists of melatonin receptors. (2) Melatonin and its analogues: 2-Phe-melatonin, 6-Cl-melatonin, 2-I-melatonin, 5- methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT) and N-acetyltryptamine all produced a reduction in intraocular pressure. Dose-response analysis for these compounds gave pD(2) values of 9.3+/-0.24 for melatonin; 9.0+/-0.09 for 6-Cl-melatonin; 9.0+/-0.84 for 2-I-melatonin; 8.9+/-0.07 for 5-MCA-NAT; 8.7+/-0.18 for 2-Phe-melatonin and 9.4+/-0.30 for N-acetyltryptamine (all n=8). (3) At a dose of 0.5 nmol (in 10 micro l) melatonin and the selective melatonin MT(3) agonist 5-MCA-NAT, induced greater reductions of intraocular pressure (22.8+/-2.3% and 32.5+/-1.4%, respectively) than the other compounds. (4) The melatonin-receptor antagonists, prazosin, DH-97 and 4-P-PDOT, reversed the effect of 5-MCA-NAT in a dose-dependent manner, with pA(2) values of 13.5+/-0.17 for prazosin, 10.6+/-0.16 for DH-97 and 9.4+/-0.20 for 4-P-PDOT (n=8). (5) Cholinoceptor antagonists (hexamethonium and atropine) and alpha(2)- and beta(2)-adrenoceptor antagonists (yohimbine and ICI 118,551) partially reversed the effects produced by melatonin and 5-MCA-NAT, suggesting the possible involvement of cholinergic and noradrenergic systems in the hypotensive actions mediated by melatonin agonists. The alpha(1)-adrenoceptor antagonist, corynanthine, had no significant effect. (6) The strong hypotensive effect of the MT(3) agonist, 5-MCA-NAT, suggests that this compound may be a useful agent for treating those pathologies where intraocular pressure is abnormally elevated.
A Low-Profile Wideband and Dual-Polarized Antenna With AMC Reflector (2021)

In this paper, a wideband dual-polarized antenna with low-profile is designed. By loading the annular branches, a new resonant point is generated at high frequency to expand the antenna bandwidth. The high impedance surface of artificial magnetic conductor (AMC) is used as a metal reflection plate to reduce the antenna profile height. The simulation results show that the return loss of the two ports is lower than -15 dB from 1.73 GHz to 2.84 GHz, and the coupling of the two ports is lower than -25dB. The cross-polarization ratio of the antenna is about 27dB. The profile height of the antenna is 0.176 λ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> at 2.2GHz (λ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> is the wavelength at free space).In the range of 1.73-2.84GHz, the proposed antenna has a stable pattern in the ± 45° polarization direction, stable gain above 8dBi and peak gain up to 9.5dBi.
Molecular cloning and evolution of transferrin cDNAs in salmonids. (1998)

Transferrin complementary DNAs were cloned from the livers of seven species in three genera of salmonids (kokanee salmon Oncorhynchus nerka, amago salmon Oncorhynchus masou ishikawa, masu salmon Oncorhynchus masou masou, Japanese char Salvelinus pluvius, brook trout Salvelinus fontinalis, lake trout Salvelinus namaycush, and brown trout Salmo trutta) subsequent to polymerase chain reaction amplification with primers derived from conserved regions of transferrin cDNA sequences. The transferrin cDNAs of the seven species of salmonids had sizes of 2.2 to 2.4 kb and encoded an open reading frame consisting of 691 amino acids with a putative signal peptide of 18 amino acids. The alignment of salmonid transferrin cDNAs showed a duplicated structure and conserved anion-binding residues, iron-binding residues, and cysteine residues for disulfide bridges. The deduced amino acid sequences of the seven salmonid transferrin cDNAs share 85% to 99% homology. A phylogenetic tree of amino acid sequences of transferrin cDNAs from salmonids showed that the relationship among the three genera of salmonids (Oncorhynchus, Salvelinus, and Salmo) is well correlated with that derived from classic morphologic and genetic analyses.
Differential sensitivity of canine cardiac sarcolemmal and microsomal enzymes to inhibition by free radical-induced lipid peroxidation. (1984)

Sarcolemmal and microsomal membranes prepared from adult canine cardiac myocytes (sarcolemmal Na+, K+-ATPase = 71.8 mumol/mg per hr and microsomal rotenone-insensitive NADH cytochrome c reductase = 114 mumol/mg per hr) were each preincubated at 37 degrees C in the presence of a free radical generating system consisting of dihydroxyfumarate and Fe -ADP; loss of the Na+, K+-ATPase and reductase activities, as well as the associated increases in lipid peroxidation, measured by malondialdehyde formation, were temporally correlated in both systems. The ATPase was inhibited 70% when the malondialdehyde was 71 nmol/mg protein at 20 minutes and 90% when malondialdehyde was 138 nmol/mg protein at 90 minutes. Inhibition of reductase activity occurred more gradually, displaying a 27% loss of activity when malondialdehyde reached 34 nmol/mg protein at 20 minutes and 60% with a malondialdehyde value of 67 nmol/mg protein at 90 minutes. The greater susceptibility of the sarcolemma to free radical-induced membrane damage may be due to the higher content of unsaturated fatty acids in this membrane, compared to microsomes.
Three Dimensional Nano “Langmuir Trough” for Lipid Studies (2015)

A three-dimensional-phospholipid monolayer with tunable molecular structure was created on the surface of oil nanodroplets from a mixture of phospholipids, oil, and water. This simple nanoemulsion preparation technique generates an in situ prepared membrane model system with controllable molecular surface properties that resembles a lipid droplet. The molecular interfacial structure of such a nanoscopic system composed of hexadecane, 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC), and water was determined using vibrational sum frequency scattering and second harmonic scattering techniques. The droplet surface structure of DPPC can be tuned from a tightly packed liquid condensed phase like monolayer to a more dilute one that resembles the liquid condensed/liquid expanded coexistence phase by varying the DPPC/oil/water ratio. The tunability of the chemical structure, the high surface-to-volume ratio, and the small sample volume make this system an ideal model membrane for biochemical research.
Supplementary Figure S2 from The MDA-9/Syntenin/IGF1R/STAT3 Axis Directs Prostate Cancer Invasion (2023)

&lt;p&gt;Manipulation of MDA-9/Syntenin expression.&lt;/p&gt;
Real-time 2-3 Pull-down Elimination Applying Motion Estimation/compensation In A Programmable Device (1998)

This paper presents a software package that performs real-time picture processing on a commercially available programmable device’. The package applies motion estimation and compensation techniques for judder-free display of movie material broadcast in 2-3 pull-down mode.
Beyond The Force (2019)

Quadcopters have been used as hovering encountered-type haptic devices in virtual reality. We suggest that quadcopters can facilitate rich haptic interactions beyond force feedback by appropriating physical objects and the environment. We present HoverHaptics, an autonomous safe-to-touch quadcopter and its integration with a virtual shopping experience. HoverHaptics highlights three affordances of quadcopters that enable these rich haptic interactions: (1) dynamic positioning of passive haptics, (2) texture mapping, and (3) animating passive props. We identify inherent challenges of hovering encountered-type haptic devices, such as their limited speed, inadequate control accuracy, and safety concerns. We then detail our approach for tackling these challenges, including the use of display techniques, visuo-haptic illusions, and collision avoidance. We conclude by describing a preliminary study (n = 9) to better understand the subjective user experience when interacting with a quadcopter in virtual reality using these techniques.
A comparison between APSK and QAM in wireless tactical scenarios for land mobile systems (2012)

We evaluate the performance of APSK modulation for wireless systems and compare it with the performance of more conventional QAM systems. In previous literature, the analysis of APSK has been mainly focused on the AWGN channel. This channel model provides useful insights when APSK is used in satellite systems, while it is important to consider more complex channel models for its use in terrestrial wireless applications. In particular, we consider wireless tactical scenarios for land mobile systems, that are of interest for military applications, and provide several numerical examples. First, we explore the effects on the total degradation of the reduced PAPR, typical of APSK, also taking into account the nonlinearity of HPAs and the need to use adaptive predistortion. Then, the bit error rate performance is assessed by simulation, for some typical multipath scenarios with decision feedback equalization, also including the presence of turbo channel coding. Our analysis shows that APSK can be a valid alternative to QAM in all cases in which the nonlinear effects due to HPAs cannot be neglected.
Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue (2020)

Perivascular adipose tissue (PVAT) is increasingly being regarded as an important endocrine organ that directly impacts vessel function, structure, and contractility in obesity-associated diseases. We uncover here a role for myeloid G protein-coupled receptor kinase 2 (GRK2) in the modulation of PVAT-dependent vasodilation responses. GRK2 expression positively correlates with myeloid- (CD68) and lymphoid-specific (CD3, CD4, and CD8) markers and with leptin in PVAT from patients with abdominal aortic aneurysms. Using mice hemizygous for GRK2 in the myeloid lineage (LysM-GRK2<sup>+/-</sup>), we found that GRK2 deficiency in myeloid cells allows animals to preserve the endothelium-dependent acetylcholine or insulin-induced relaxation, which is otherwise impaired by PVAT, in arteries of animals fed a high fat diet (HFD). Downregulation of GRK2 in myeloid cells attenuates HFD-dependent infiltration of macrophages and T lymphocytes in PVAT, as well as the induction of tumor necrosis factor-α <b>(</b>TNFα) and NADPH oxidase (Nox)1 expression, whereas blocking TNFα or Nox pathways by pharmacological means can rescue the impaired vasodilator responses to insulin in arteries with PVAT from HFD-fed animals. Our results suggest that myeloid GRK2 could be a potential therapeutic target in the development of endothelial dysfunction induced by PVAT in the context of obesity.
Taking Advice from (Dis)Similar Machines: The Impact of Human-Machine Similarity on Machine-Assisted Decision-Making (2022)

Machine learning algorithms are increasingly used to assist human decision-making. When the goal of machine assistance is to improve the accuracy of human decisions, it might seem appealing to design ML algorithms that complement human knowledge. While neither the algorithm nor the human are perfectly accurate, one could expect that their complementary expertise might lead to improved outcomes. In this study, we demonstrate that in practice decision aids that are not complementary, but make errors similar to human ones may have their own benefits. In a series of human-subject experiments with a total of 901 participants, we study how the similarity of human and machine errors influences human perceptions of and interactions with algorithmic decision aids. We find that (i) people perceive more similar decision aids as more useful, accurate, and predictable, and that (ii) people are more likely to take opposing advice from more similar decision aids, while (iii) decision aids that are less similar to humans have more opportunities to provide opposing advice, resulting in a higher influence on people’s decisions overall.
Adipokines as novel biomarkers and regulators of the metabolic syndrome (2010)

Over the past two decades our view of adipose tissue has undergone a dramatic change from an inert energy storage tissue to an active endocrine organ. Adipose tissue communicates with other central and peripheral organs by synthesis and secretion of a host of molecules that we generally refer to as adipokines. The levels of some adipokines correlate with specific metabolic states and have the potential to impact directly upon the metabolic homeostasis of the system. A dysregulation of adipokines has been implicated in obesity, type 2 diabetes, hypertension, cardiovascular disease, and an ever-growing larger list of pathological changes in a number of organs. Here, we review the recent progress regarding the synthesis, secretion, and physiological function of adipokines with perspectives on future directions and potential therapeutic goals.
Prevalencia de caries dental e incidencia de la pérdida de primeros molares permanentes en los alumnos de 10 a 12 años de edad de las unidades educativas ¨gabriela mistral¨ y ¨colegio la independencia¨ en puerto ayacucho, edo. Amazonas. (2015)

La caries dental es una enfermedad cronica, infecciosa, transmisible y multifactorial, relacionada con higiene bucal deficiente, alto consumo de alimentos cariogenicos, colonizacion bacteriana y bajo nivel socioeconomico, constituyendo la principal causa de perdida prematura de primeros molares permanentes y convirtiendose en un grave problema de salud publica para la poblacion infantil. Objetivos: Determinar la relacion entre la prevalencia de Caries dental y la perdida prematura de los primeros molares permanentes en ninos de 10 a 12 anos de edad pertenecientes al Edo. Amazonas. Materiales y metodos: Se utilizo una ficha odontologica como instrumento de recoleccion de datos a traves de la evaluacion clinica, la toma del indice CPOD/ceod y la realizacion de una encuesta de frecuencia en el consumo de alimentos cariogenicos. Resultados: De la muestra conformada por 110 ninos, el 91% presento caries dental con un total de 93 dientes afectados para ceo-d y 250 para CPO-D, determinando un indice ceod/CPOD de 2.09 y 2.89 respectivamente. El 31% presento perdida de primeros molares permanentes con un total de 40 piezas afectadas. El 69% consume elevadas proporciones de azucares entre comidas, un 75% consume alimentos pegajosos y el 97.27% refrescos y jugos pasteurizados. Conclusiones: observamos una moderada prevalencia y alta experiencia de caries dental, asi como una elevada ingesta de dietas cariogenicas en la muestra total, hecho directamente proporcional al establecimiento de dicha enfermedad y a la incidencia en la perdida de primeros molares permanentes, lo que exige acciones de mejoramiento y estrategias en salud publica para esta poblacion.