gebhart/patrepeval huggingface dataset:
Capecitabine-Associated Ileocolitis Diagnosed on Colonoscopy (2018)

Capecitabine is considered a first line agent in adjuvant therapy for colorectal cancer. One of its adverse effects however is that it can commonly be associated with GI side-effects such as diarrhea. When the diarrhea is severe and prolonged, capecitabine associated enterocolitis should be strongly considered in the differential. Herein, we present a rare case of capecitabine enterocolitis, specifically involving the distal ileum and ascending colon, demonstrating the role of colonoscopy in diagnosis. Additionally, this case is meant to demonstrate the disease course and provide our experience in treating this rare condition. We present a 72-year-old female with stage IIIC ascending colon adenocarcinoma who underwent laparoscopic right hemicolectomy started on adjuvant chemotherapy with capecitabine. She was initiated on capecitabine monotherapy for a planned 6 months, however after one month of tolerating the medication, she developed severe, prolonged, and painless diarrhea ultimately lasting 4 weeks. Infectious and ischemic workup was negative. Her initial CT abdomen and pelvis was significant for mildly dilated fluid-filled loops of small bowel with adjacent engorgement of vasa recta and mesenteric edema concerning for enteritis. This was followed up with colonoscopy with ileoscopy finding evidence of granular erythematous mucosa with ulceration both above and below the ileocolonic anastomosis in the distal ileum and ascending colon. Ileal biopsy showed mucosal erosion with acute and chronic inflammation and occasional atypical gland. Our treatment approach with anti-motility agents, cholestyramine, octreotide and oral steroids were largely ineffective in treating the diarrhea. The patient ultimately required TPN to address the patient's severe protein deficiency and malnutrition secondary to the ileocolitis.1570_A Figure 1. A. Axial CT of the abdomen demonstration vasa recta engorgement and mesenteric edema. B. Coronal CT of the abdomen with “comb sign” demonstrating vasa recta engorgement and mesenteric edema1570_B Figure 2. Colonoscopy showing granular erythematous mucosa of the ascending colon (2A and 2B) distal to the ileocolonic anastamosis. Ileoscopy reveals evidence of ulceration in the distal ileum (2C and 2D)To date, there have only been 8 cases published that describe Capecitabine associated enterocolitis, and only 2 of these cases documented colonoscopic evidence revealing ulceration of the ileum. Our case will be the 3rd case which utilized colonoscopic and pathologic evidence of ileal ulceration. In all the published cases, approach to management posed a significant challenge. It appears that a trial of cessation of Capecitabine, fluid and nutritional resuscitation with TPN have shown some benefit. With all cases it appears that capecitabine enterocolitis requires time to ultimately resolve itself.
Optimization problem for forseeable lightpath demands (2005)

The foreseeable lightpath demands (FLD) include scheduled lightpath demands (SLD) and predictable lightpath demands (PLD, lightpath demands that can be approximatively forecasted through the history traffic record). Since the time disjointness each FLD, the network planner can design the capacity of the network more compactly. We formulate the routing and wavelength assignment (RWA) problem when network dimensioning is coupled as the Integer linear programming (ILP) which includes the link formulation and path formulation. To reduce the computing complexity, a new routing algorithm based on the consideration of backup path is proposed. The software experiment is run and shows that the gain is about 20% when the backup path needs to be setup. At last we propose a new RWA algorithm to adapt the FLDs and dynamic traffic into the wavelength routing network.
Fourier Homogenization Method and the Propagation of Acoustic Waves Through a Periodic Vortex Array (1999)

The classical problem of homogenization of elliptic operators in arbitrary domains with periodically oscillating coefficients is considered. As the period goes to zero, an asymptotic analysis of the corresponding sequence of operators is performed with the help of this new method which we call in a natural way the Fourier homogenization method, since it is based on the standard Fourier transform. This method offers an alternative way to view the classical results in homogenization. It works in the Fourier space and thus in a framework dual to the one used in most of the mathematical approaches to this subject. The Fourier homogenization method is then used to derive an expression for the effective speed of sound for an acoustic wave that propagates through a background flow made up of a periodic array of vortices, in the limit of wavelength large compared with the lattice spacing. The main result is an effective speed of sound that depends on the relative orientation between wave vector and lattice. Examples in two and three dimensions are provided.
Roadblocks to success for RNA CARs in solid tumors (2014)

While CAR therapy has begun to demonstrate efficacy, cell-engineering techniques that result in permanent genomic modification carry several safety concerns. CAR expression driven by RNA creates a platform for delivery of highly-active cell therapy while avoiding long-term CAR-driven toxicity. Using models of pediatric neuroblastoma, we have found that RNA CAR T cell activity is limited by ineffective tumor infiltration.
The Synthesis of Some New Derivatives Derived from 1,2,3,4-Tetrahydrocyclohepteno[4,5]thieno-[2,3- d ]pyrimidine (2006)

Polynuclear thieno[2,3-d]pyrimidone derivatives had been synthesized by an intermolecular reaction of 2-hydrazino-thieno[2,3-d]pyrimidin-4-one (1) with each of the aliphatic acids, and carbon disulfide afforded thienotriazolepyrimidin-5-one derivatives. On the other hand, compound 1 that condensed with α-haloketone yielded thienopyrimidotriazine, and with β-diketones and β-ketoesters formed 2-(1-pyrazolyl) derivatives. Also, the condensation of compound 1 with aromatic aldehydes gave arylhydrazones. The purpose of synthesis the thienopyrimidine derivatives is due to high biological activities. 4-chloro derivatives exhibited spasmodic and antiviral activity, and also 4-amino derivatives showed antimicrobial, insecticidal, pesticidal, and acaricidal activity.
Multiple factors bind the upstream activation sites of the yeast enolase genes ENO1 and ENO2: ABFI protein, like repressor activator protein RAP1, binds cis-acting sequences which modulate repression or activation of transcription. (1990)

Binding sites for three distinct proteins were mapped within the upstream activation sites (UAS) of the yeast enolase genes ENO1 and ENO2. Sequences that overlapped the UAS1 elements of both enolase genes bound a protein which was identified as the product of the RAP1 regulatory gene. Sequences within the UAS2 element of the ENO2 gene bound a second protein which corresponded to the ABFI (autonomously replicating sequence-binding factor) protein. A protein designated EBF1 (enolase-binding factor) bound to sequences which overlapped the UAS2 element in ENO1. There was a good correlation among all of the factor-binding sites and the location of sequences required for UAS activity identified by deletion mapping analysis. This observation suggested that the three factors play a role in transcriptional activation of the enolase genes. UAS elements which bound the RAP1 protein or the ABFI protein modulated glucose-dependent induction of ENO1 and ENO2 expression. The ABFI-binding site in ENO2 overlapped sequences required for UAS2 activity in wild-type strains and for repression of ENO2 expression in strains carrying a null mutation in the positive regulatory gene GCR1. These latter results showed that the ABFI protein, like the RAP1 protein, bound sequences required for positive as well as negative regulation of gene expression. These observations strongly suggest that the biological functions of the RAP1 and ABFI proteins are similar.
Tracking the Vampire (1991)

Research Article| July 01 1991 Tracking the Vampire Sue-Ellen Case Sue-Ellen Case Sue-Ellen Case is professor of English at the University of California, Riverside. The past editor of Theatre Journal, her most recent book is Performing Feminisms: Feminist Critical Theory and Theatre (Baltimore: Johns Hopkins UP, 1989). Search for other works by this author on: This Site Google differences (1991) 3 (2): 1–20. https://doi.org/10.1215/10407391-3-2-1 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Sue-Ellen Case; Tracking the Vampire. differences 1 July 1991; 3 (2): 1–20. doi: https://doi.org/10.1215/10407391-3-2-1 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll Journalsdifferences Search Advanced Search The text of this article is only available as a PDF. Copyright © 1991 by Brown University and differences: A Journal of Feminist Cultural Studies1991 Article PDF first page preview Close Modal You do not currently have access to this content.
Assessment of urodynamic bladder behavior on filling with solutions representing physiological extremes of urinary osmolarity (2005)

The vesical filling with solutions simulating extreme urinary osmolarities, accomplished with similar speed and without previous identification, did not likewise alter the sensitive and motor urodynamic behavior in the current study.
Tricyclic Fused Pyrazoles with a ‘Click’ 1,2,3-Triazole Substituent in Position 3 Are Nanomolar CB1 Receptor Ligands (2015)

Structural modification of the potent conformationally constrained tricyclic pyrazole CB<sub>1</sub> ligand NESS0327 was achieved by replacing: (1) the chlorine substituent on the tricycle with a 3-fluoropropyl chain, and (2) the pyrazole 3-{[(piperidino)amino]carbonyl} substituent with a 4-substituted 1,2,3-triazole group obtained by click chemistry from an alkynyl precursor. Among the resulting compounds, two are particularly promising candidates for [<sup>18</sup>F]radiolabelling and PET imaging studies of the CB<sub>1</sub> receptor, as they displayed <i>K</i> <sub>i</sub> CB<sub>1</sub> = 62.5 nM and 42.5 nM, respectively, in the same range as that displayed by rimonabant.
The Streptococcal Protease SpeB Antagonizes the Biofilms of the Human Pathogen Staphylococcus aureus USA300 through Cleavage of the Staphylococcal SdrC Protein (2020)

<i>Streptococcus pyogenes</i>, or group A <i>Streptococcus</i> (GAS), is both a pathogen and an asymptomatic colonizer of human hosts and produces a large number of surface-expressed and secreted factors that contribute to a variety of infection outcomes. The GAS-secreted cysteine protease SpeB has been well studied for its effects on the human host; however, despite its broad proteolytic activity, studies on how this factor is utilized in polymicrobial environments are lacking. Here, we utilized various forms of SpeB protease to evaluate its antimicrobial and antibiofilm properties against the clinically important human colonizer <i>Staphylococcus aureus</i>, which occupies niches similar to those of GAS. For our investigation, we used a skin-tropic GAS strain, AP53CovS+, and its isogenic Δ<i>speB</i> mutant to compare the production and activity of native SpeB protease. We also generated active and inactive forms of recombinant purified SpeB for functional studies. We demonstrate that SpeB exhibits potent biofilm disruption activity at multiple stages of <i>S. aureus</i> biofilm formation. We hypothesized that the surface-expressed adhesin SdrC in <i>S. aureus</i> was cleaved by SpeB, which contributed to the observed biofilm disruption. Indeed, we found that SpeB cleaved recombinant SdrC <i>in vitro</i> and in the context of the full <i>S. aureus</i> biofilm. Our results suggest an understudied role for the broadly proteolytic SpeB as an important factor for GAS colonization and competition with other microorganisms in its niche.<b>IMPORTANCE</b><i>Streptococcus pyogenes</i> (GAS) causes a range of diseases in humans, ranging from mild to severe, and produces many virulence factors in order to be a successful pathogen. One factor produced by many GAS strains is the protease SpeB, which has been studied for its ability to cleave and degrade human proteins, an important factor in GAS pathogenesis. An understudied aspect of SpeB is the manner in which its broad proteolytic activity affects other microorganisms that co-occupy niches similar to that of GAS. The significance of the research reported herein is the demonstration that SpeB can degrade the biofilms of the human pathogen <i>Staphylococcus aureus</i>, which has important implications for how SpeB may be utilized by GAS to successfully compete in a polymicrobial environment.
Monocyte chemoattractant protein‐1 and coronary artery disease (2002)

The designation of atherosclerosis as a chronic inflammatory process represents an exciting and logical paradigm shift for cardiologists. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the recruitment and activation of monocytes and thus in the development of atherosclerosis. Enhanced MCP-1 expression has been detected in macrophages, endothelial cells, and vascular smooth muscle cells in the atheromatous plaque. Activation of macrophages by MCP-1 also appears to be involved in the vulnerability of the plaque. Indeed, circulating MCP-1 levels are elevated in patients with acute myocardial infarction and in those with unstable angina, but not in patients with stable angina. Production of MCP-1 and macrophage accumulation are also observed after coronary angioplasty or grafting, indicating that MCP-1 expression may be related not only to instability of atheromatous plaques, but also to the formation of restenotic lesions. The development of therapeutic drugs for atherosclerosis targeted specially against MCP-1 may be useful in the prevention of plaque formation and future myocardial infarction.
Purinergic receptors activating rapid intracellular Ca2+ increases in microglia (2005)

We provide both molecular and pharmacological evidence that the metabotropic, purinergic, P2Y(6), P2Y(12) and P2Y(13) receptors and the ionotropic P2X(4) receptor contribute strongly to the rapid calcium response caused by ATP and its analogues in mouse microglia. Real-time PCR demonstrates that the most prevalent P2 receptor in microglia is P2Y(6) followed, in order, by P2X(4), P2Y(12), and P2X(7) = P2Y(13). Only very small quantities of mRNA for P2Y(1), P2Y(2), P2Y(4), P2Y(14), P2X(3) and P2X(5) were found. Dose-response curves of the rapid calcium response gave a potency order of: 2MeSADP>ADP=UDP=IDP=UTP>ATP>BzATP, whereas A2P4 had little effect. Pertussis toxin partially blocked responses to 2MeSADP, ADP and UDP. The P2X(4) antagonist suramin, but not PPADS, significantly blocked responses to ATP. These data indicate that P2Y(6), P2Y(12), P2Y(13) and P2X receptors mediate much of the rapid calcium responses and shape changes in microglia to low concentrations of ATP, presumably at least partly because ATP is rapidly hydrolyzed to ADP. Expression of P2Y(6), P2Y(12) and P2Y(13) receptors appears to be largely glial in the brain, so that peripheral immune cells and CNS microglia share these receptors. Thus, purinergic, metabotropic, P2Y(6), P2Y(12), P2Y(13) and P2X(4) receptors might share a role in the activation and recruitment of microglia in the brain and spinal cord by widely varying stimuli that cause the release of ATP, including infection, injury and degeneration in the CNS, and peripheral tissue injury and inflammation which is signaled via nerve signaling to the spinal cord.
The methylation, neurotransmitter, and antioxidant connections between folate and depression. (2008)

Depression is common - one-fourth of the U.S. population will have a depressive episode sometime in life. Folate deficiency is also relatively common in depressed people, with approximately one-third of depressed individuals having an outright deficiency. Folate is a water-soluble B-vitamin necessary for the proper biosynthesis of the monoamine neurotransmitters serotonin, epinephrine, and dopamine. The active metabolite of folate, 5-methyltetrahydrofolate (5-MTHF, L-methylfolate), participates in re-methylation of the amino acid metabolite homocysteine, creating methionine. S-adenosylmethionine (SAMe), the downstream metabolite of methionine, is involved in numerous biochemical methyl donation reactions, including reactions forming monoamine neurotransmitters. Without the participation of 5-MTHF in this process, SAMe and neurotransmitter levels decrease in the cerebrospinal fluid, contributing to the disease process of depression. SAMe supplementation was shown to improve depressive symptoms. 5-MTHF also appears to stabilize, enhance production of, or possibly act as a substitute for, tetrahydrobiopterin (BH4), an essential cofactor in monoamine neurotransmitter biosynthesis. There are few intervention studies of folic acid or 5-MTHF as a stand-alone treatment for depression related to folate deficiency; however, the studies that have been conducted are promising. Depressed individuals with low serum folate also tend to not respond well to selective serotonin reuptake inhibitor (SSRI) antidepressant drugs. Correcting the insufficiency by dosing folate along with the SSRI results in a significantly better antidepressant response.
Simulation of nucleation and growth processes. Application to nickel electrocrystallization in aqueous solutions (1999)

A comprehensive approach of the mechanisms of electrochemical processes involving nucleation and crystal growth is described. The study is based on the use of transient electrochemical techniques which prove to be useful in determining the kinetics of reaction steps. Fundamental equations are derived to obtain a precise knowledge of transport and growth processes in solids. Since algebraic solutions are not available, quantitative results are obtained by numerical calculations. An application to the study of nickel deposition in acidic solutions is given.
Optimization of Soil Moisture Environment by Applying Simulation on Sub-irrigation Method (I) : Reappearance Trial in the Distribution of Soil Moisture Tension (1993)

This study was carried out to clarify the reappearance method which shows the distribution of soil moisture in the sub-irrigation method by using negative pressure difference. On the other hand, there are many methods to reappear the distributions of soil moisture tension, but in this study, the conformal mapping method was applied to reappear them at the steady state. Consequently, it is found that the distributions of soil moisture tension could be reappeared to the different cases in the sub-irrigation method by using negative pressure difference. Also it is found that the different depth and different outer radius of porous pipe buried in the sub-irrigation method largely influence the distributions of soil moisture tension.
Emulating one-dimensional resonantQ-matching behavior in a two-dimensional system via Fano resonances (2006)

Through detailed numerical and analytical studies, we establish that the significant enhancement of thermal emission via $Q$ matching, which has been possible in one-dimensional (1D) systems only, can be extended to two-dimensional (2D) systems by means of Fano resonances in the 2D system. In particular, we show the existence of essentially 1D behavior in a 2D system---a case of reduced dimensionality. Moreover, we show how properties of these spectra can be controlled by changing the geometrical parameters of the 2D system.
Decoding of DBEC-TBED Reed-Solomon Codes (1987)

A problem in designing semiconductor memories is to provide some measure of error control without requiring excessive coding overhead or decoding time. In LSI and VLSI technology, memories are often organized on a multiple bit (or byte) per chip basis. For example, some 256K bit DRAM's are organized in 32K × 8 bit-bytes. Byte-oriented codes such as Reed-Solomon (RS) codes can provide efficient low overhead error control for such memories. However, the standard iterative algorithm for decoding RS codes is too slow for these applications. In this correspondence we present a special decoding technique for double-byte-error-correcting (DBEC), triple-byte-error-detecting (TBED) RS codes which is capable of high-speed operation. This technique is designed to find the error locations and the error values directly from the syndrome without having to use the iterative algorithm to find the error locator polynomial.
Deep Learning to replace or augment model-based seismic inversion? (2023)

Summary Seismic inversion represents a fundamental step in the process of linking seismic data to subsurface properties. Recently, many practitioners have started to argue that purely data-driven methodologies can outperform state-of-the-art model-based algorithms. In this work, we perform a systematic comparison between a variety of model-based, data-driven, and hybrid seismic inversion schemes and show that the above statement is only valid under favourable conditions, namely access to a dense distribution of wells capturing most (if not all) of the geological features in the subsurface of interest and knowledge of the background model (similar to model-based inversion). Finally, we propose a novel strategy that incorporates data-driven estimates as soft-prior in hybrid inversion schemes, achieving best-in-class accuracy over all other methods.
Knowledge exchange (2017)

In this column the authors describe a conscious partnership between the university research administration office and the academic library, laying out the rationale for such cooperation and describing the benefits to their respective departments and to their stakeholders more broadly.
An effective compression scheme for multilead ECG signals containing ectopie ventricular activation (1992)

When recording 64 channel high resolution (0.75μV per bit) eletrocardiograms, datatile compression becomes necessary. It is shown that these files can be stored with 5 bits per sample at 500 Hz sampling rate. The preferred method consists of computing the second order derivative and Huffman encoding of the residue. By using this data compression technique, polymorphic ventricular tachycardia recordings which have a larger information content can be compressed to nearly the same volume as sinus rhythm. It is not necessary to find the optimal Huffman coding for every recording. A fixed encoding scheme can be used without significant increase in file length.
Acoustical properties of historical theatres (2018)

This paper deals with acoustic parameters of the historical
theatres. Until now we have measured acoustical parameters in
historical theatres in Ceský Krumlov (The Czech Republic),
Drottningholm (Sweden), Litomysl (The Czech Republic), Weitra
(Austria) and Gotha (Germany). The acoustic simulation of
theatres was performed using ODEON® software. All models were
calibrated according to measured reverberation time in the
theatres. In this paper a comparison of the mentioned theatres
is performed from point of view of acoustics and other
interesting aspects. © Akustika, 2018.