gebhart/patrepeval huggingface dataset:
Retrospective Evaluation of the Exposure to Polycyclic Aromatic Hydrocarbons: Comparative Assessments with a Job Exposure Matrix and by Experts in Industrial Hygiene (1993)

This work aimed at assessing the validity of job exposure matrix (JEM) for the retrospective evaluation of exposure to polycyclic aromatic hydrocarbons (PAH) within the framework of population-based case-control studies, taking the evaluation of industrial hygiene experts as reference. For this purpose, we used a case-control study for which the different levels of exposure were assessed by such experts after case by case evaluation of all job periods reported by the subjects. The JEM was applied to this set of data so that we had, according to job periods, the experts' evaluation on the one hand, and the JEM evaluation on the other. JEM sensitivity and specificity of the matrix vary widely from 0.13 to 0.96 and 0.58 to 0.99 respectively, depending on whether the experts chose a narrow or wide definition of exposure and on the cutoff point chosen to dichotomize the JEM. We also computed, according to the sensitivity and specificity of the JEM, the odds ratio (OR) and relative efficiency (RE) given by the JEM for several hypothetical OR and frequencies of exposure among the controls. These calculations were made for different definitions of exposure by the experts and different cutoff points for the JEM. The results show a bias in the JEM's evaluation of the OR. In addition, the RE varies widely from very low values to high values (0.05-0.45) depending on the experts' definition of exposure and the cutoff point chosen for the matrix. Note, however, that all these calculations were made taking the experts' evaluation as the reference.(ABSTRACT TRUNCATED AT 250 WORDS)
Unipolar Sequential Circuits Based on Individual-Carbon-Nanotube Transistors and Thin-Film Carbon Resistors (2011)

A fabrication process for the monolithic integration of field-effect transistors based on individual carbon nanotubes and load resistors based on vacuum-evaporated carbon films into fast unipolar logic circuits on glass substrates is reported for the first time. The individual-carbon-nanotube transistors operate with relatively small gate-source and drain-source voltages of 1 V and combine large transconductance (up to 6 μS), large ON/OFF ratio (>10(4)), and short switching delay time constants (12 ns). The thin-film carbon load resistors provide linear current-voltage characteristics and resistances between 300 kΩ and 100 MΩ, depending on the layout of the resistors and the thickness of the vacuum-evaporated carbon films. Various combinational circuits (NAND, NOR, AND, OR gates) as well as a sequential circuit ( ̅S ̅R NAND latch) have been fabricated and characterized. Although these unipolar circuits cannot compete with optimized complementary circuits in terms of integration density and static power consumption, they offer the possibility of realizing air-stable, low-voltage integrated circuits with promising static and dynamic performance on unconventional substrates for large-area electronics applications, such as displays or sensors.
Physiologic Mechanisms of Postischemic Tissue Injury (1995)

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...Read More
Theiler's disease associated with administration of tetanus antitoxin contaminated with nonprimate (equine) hepacivirus and equine parvovirus‐hepatitis virus (2018)

Summary An 11‐year‐old Trakehner gelding was presented for evaluation of lethargy, decreased appetite, mild icterus, and elevated hepatic enzyme activities. Physical examination, serum chemistry results, and liver biopsy histopathologic findings were supportive of Theiler's disease. Polymerase chain reaction ( PCR ) testing results of serum and liver tissue were positive for nonprimate (equine) hepacivirus ( NPHV ) and a novel equine parvovirus‐hepatitis virus (Eq PV ‐H). PCR testing of the lot of tetanus antitoxin administered to the gelding 3 months previously also yielded positive results for NPHV and Eq PV ‐H. Treatment included supportive care and clinical signs resolved within 1 week, although hepatic enzyme activities remained elevated for several months. The horse successfully returned to work as a hunter/jumper for about 1 year until it developed a forelimb lameness and progressive atrophy of shoulder musculature (sweeney), prompting a decision for euthanasia 20 months after initial evaluation. Serial PCR testing of serum revealed persistent infection with both NPHV and Eq PV ‐H and necropsy examination revealed chronic active hepatitis, mild liver atrophy, and positive PCR results for NPHV and Eq PV ‐H in liver tissue. This case highlights the possible risk of administering potentially contaminated biologics of equine origin and the importance of screening for recently identified hepatic viruses in donors from which blood products are prepared.
SCOREGOF: Stata module to perform Score test of normality for probit and bivariate probit (2012)

scoregof is a postestimation command for probit, dprobit, and biprobit. It computes a goodness-of-fit score test.
Putting the fizz into chemistry: applications of supercritical carbon dioxide in tissue engineering, drug delivery and synthesis of novel block copolymers (2007)

This paper describes the recent progress at Nottingham towards the exploitation of the unique properties of scCO(2) (supercritical carbon dioxide) for the preparation of polymeric scaffolds for tissue engineering applications and new devices for controlled drug delivery, as well as the synthesis of novel block copolymers by the combination of eROP (enzymatic ring opening polymerization) and controlled polymerization methods for the potential use as drug carriers.
Determination of intrinsic effective fields and microwave polarizations by high-resolution spectroscopy of single nitrogen-vacancy center spins (2019)

Abstract We present high-resolution optically detected magnetic resonance spectroscopy on single nitrogen-vacancy (NV) center spins in diamond at and around zero magnetic field. The experimentally observed transitions depend sensitively on the interplay between the microwave (MW) probing field and the local intrinsic effective field comprising strain and electric fields, which act on the NV spin. Based on a theoretical model of the magnetic dipole transitions and the MW driving field, we extract both the strength and the direction of the transverse component of the effective field. Our results reveal that for the diamond crystal under study, strain is the dominant contribution to the effective field. Our experiments further yield a method for MW polarization analysis in a tunable, linear basis, which we demonstrate on a single NV spin. Our results are of importance to low-field quantum sensing applications using NV spins and form a relevant addition to the ever-growing toolset of spin-based quantum sensing.
Screening of miRNAs in plasma as a diagnostic biomarker for cardiac disease based on optimization of extraction and qRT-PCR condition assay through amplification efficiency (2021)

This is the first study to optimize extraction and qRT-PCR conditions, while improving miRNA yields and minimizing the loss of extracted miRNA by evaluations of the amplification efficiency.
Media evaluation of lactic acid repeated-batch fermentation with Lactobacillus plantarum and casei subsp. rhamnosus (1998)

This paper describes a methodology to evaluate different fermentation media without interruption for long-term repeated batch fermentation by Lactobacillus casei subsp. rhamnosus or Lactobacillus plantarum. A repeated-batch fermentor was designed to evaluate various food byproducts as nitrogen source to replace yeast extract in lactic acid fermentation. Seven types of livestock- or marine-based byproducts were used in addition to corn steep liquor and yeast extract. Also, further enrichment of vitamins and minerals in the fermentation media was performed by the addition of 0.1% cane molasses. Data from lactic acid fermentation in duplicate were analyzed by analysis of variance and least significant difference. Marine hydrolysate BAP5301 supplemented with cane molasses resulted in a higher lactic acid production rate than that of yeast extract medium for L. plantarum. On the other hand, marine hydrolysate BAP5300 supplemented with cane molasses was the best for L. casei, which produced lactic acid similar to yeast extract supplemented medium.
Self-excited Synchronous Machine with High Torque Capability at Zero Speed (2018)

This paper presents an advanced self-excited synchronous machine design with high torque capability already at zero and lower operation speed. The stator winding is composed of a novel multiphase fractional slot concentrated winding (FSCW) which has the ability to generate various magneto motive force (MMF) waves and to control their amplitudes and frequencies independently. While, the rotor contains two winding sets, and a multiphase diode rectifier connected between them. At zero and lower operation speed, the rotor excitation is performed via harmonic currents, while for higher speeds using MMF winding harmonics. As results, the proposed machine can operate with high torque capability over the complete speed range. The functionality of the new machine has been proved with finite elements for different load conditions.
Design of Magnetic Couplings for Bioreactors: Analytical Treatment and Optimization (2018)

In this work, investigation of magnetic couplers used in industrial applications such as bioreactors for mixing of liquids has been performed. Nowadays, the best solution as to contamination problems associated with mixing in stirred tank bioreactors is magnetic coupling. In this investigation, analytical treatment was carried out for the factors affecting the value of critical torque. These are: materials of the main design details, permanent magnet (PM) shape, PM width and height, the number of pole pairs, and the air gap. In the framework of investigation, design improvement and optimization were performed for $1 m^{3}, 4m^{3}, 15m^{3}$ magnetic couplings (JSC “Biotehniskais Centrs” production). The results of numerical modelling were compared with those obtained experimentally.
Study on Interaction Between Undercrossing Shield Tunneling and Adjacent Structure in Different Distance (2011)

The influence of undercrossing shield tunneling and its interaction with surrounding environment is one of the hot issues in the underground engineering field.The urban tunnel construction will cause the deformation or even damage of the nearby buildings.With the construction of undercrossing tunnels,more and more undercrossing tunnels are adjacent buildings.It is a crucial problem to ensure the safety for stabilizing the superstructure and undercrossing tunnels.By means of 3D-FEM,the undercrossing shield tunneling construction of adjacent structures is simulated and studied.The results show that the influence of adjacent structure on the undercrossing shield tunneling construction cannot be neglected,and the influence scope can be expressed by L/D,which L is defined as level distance from the new tunnel axis to building axis and D is defined as outer diameter of tunnel.When L/D =0 to 2,undercrossing shield tunnel construction has great influence on building,especially,the building is in danger when L/D =1.5.When L/D =0 to 3,the value of the existing tunnel deformation and the new tunnel lining force increases obviously.Out of the region,the influence on the buildings is ignored.
Bifunctional Charge Transfer Operated Fluorescent Probes with Acceptor and Donor Receptors. 1. Biphenyl-Type Sensor Molecules with Protonation-Induced Anti-Energy Gap Rule Behavior (2006)

On the basis of biphenyl (b) type molecules bpb-R substituted with a 2,2':6',2' '-terpyridine acceptor (bp) and either amino-type donor receptors (R = dimethylamino (DMA), A15C5 = monoaza-15-crown-5) or nonbinding substituents (R = CF(3), H, OMe) of various donor strengths, we developed a family of charge transfer (CT) operated monofunctional and bifunctional fluorescent sensors for protons and metal ions. These molecules are designed to communicate the interaction of an analyte with the acceptor and the donor receptor differing in basicity and cation selectivity by clearly distinguishable spectral shifts and intensity modulations in absorption and in emission as well as in fluorescence lifetime. From the dependence of the fluorescence spectra, fluorescence quantum yields, and fluorescence lifetimes of bpb-R on solvent polarity and proton concentration, the photophysics of bpb-R and their protonated analogues can be shown to be governed by the relaxation to a CT state of forbidden nature and by the switching between anti-energy and energy gap law type behaviors. This provides the basis for analytically favorable red shifted emission spectra in combination with comparatively high fluorescence quantum yields. Accordingly, bpb-H and bpb-OMe are capable of ratiometric emission signaling of protons. bpb-DMA reveals a protonation-induced ON-OFF-ON switching of its emission.
The role of Machine Learning in Predicting CABG Surgery Duration (2011)

Context. Operating room (OR) is one of the most expensive resources of a hospital. Its mismanagement is associated with high costs and revenues. There are various factors which may cause OR mismanagement, one of them is wrong estimation of surgery duration. The surgeons underestimate or overestimate surgery duration which causes underutilization or overutilization of OR and medical staff. Resolving the issue of wrong estimate can result improvement of the overall OR planning. Objectives. In this study we investigate two different techniques of feature selection, compare different regression based modeling techniques for surgery duration prediction. One of these techniques (with lowest mean absolute) is used for building a model. We further propose a framework for implementation of this model in the real world setup. Results. In our case the selected technique (correlation based feature selection with best first search in backward direction) for feature selection could not produce better results than the expert’s opinion based approach for feature selection. Linear regression outperformed on both the data sets. Comparatively the mean absolute error of linear regression on experts’ opinion based data set was the lowest. Conclusions. We have concluded that patterns exist for the relationship of the resultant prediction (surgery duration) and other important features related to patient characteristics. Thus, machine learning tools can be used for predicting surgery duration. We have also concluded that the proposed framework may be used as a decision support tool for facilitation in surgery duration prediction which can improve the planning of ORs and their resources.
Effect of Aging on Lees and of Three Different Dry Yeast Derivative Products on Verdejo White Wine Composition and Sensorial Characteristics (2011)

A study was made of the effect of aging on lees and of three different commercial yeast derivative products of different composition and degree of purification on the phenolic compounds, color, proteins, polysaccharides, and sensorial characteristics of white wines. The results obtained showed that the lees and yeast derivative products can interact or adsorb some of the phenolic compounds present in wines, reducing their concentration. This reduction depends on the treatment applied, the phenolic compound analyzed, and the stage of vinification or aging process. The use of lees and yeast derivative products can reduce the color intensity and the browning of the wines immediately following treatment. The monosaccharide and polysaccharide content of yeast derivative products depends on the manufacturing process and degree of purification of the product, both of which have an influence on wine treatments. After 6 months in the bottle, both the aging on lees and the treatment with commercial yeast derivative products gave rise to wines with better sensorial characteristics than in the case of the control wines.
Association of class II HLA alleles with susceptibility to develop immune‐mediated diseases in Paraguayan patients (2022)

Genetic and nongenetic factors are involved in the pathogenesis of immune-mediated inflammatory diseases (IMIDs). The best-known genetic factor for susceptibility to IMIDs is the human leukocyte antigen (HLA). The aim of the present study was to evaluate the association of HLA class II genes with the risk of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc) in the Paraguayan population. We included 254 patients with IMIDs (101 SLE, 103 RA, and 50 SSc) and 50 healthy controls. The haplotypes of five genes corresponding to HLA class II genes and their relationship to the IMIDs studied were determined. Note that 84.6% were women, with a mean age of 43.4 ± 14 years. Among the associated HLA alleles, we found the previously identified risk factors in other populations like HLA-DRB1*03:01 and HLA-DRB1*14:02 for RA, as well as new ones not previously identified, such as DPA1*02:01 for SLE and, DB1*02:01 for RA and SSc. In the genetic association analysis, already known associations have been replicated, and unpublished associations have been identified in Paraguayan patients with IMIDs. This is the first genetic association study in Paraguayan patients with IMIDs.
Whose Safety?: Regulation of the Sex Industry in Western Australia (2010)

In 2008, the Carpenter Labor Government attempted to introduce legislation that would have decriminalised Western Australia's sex industry. The legislation was the result of an extensive review conducted by a working party that valued transparency and accountability, and incorporated a lengthy process of consultation with a wide variety of key stakeholders. The consultation process involved input from sex workers; an approach that most would consider obligatory, but is in fact rarely adopted.
Metastatic Lung Lesions as a Preferred Resection Site for Immunotherapy With Tumor Infiltrating Lymphocytes (2016)

Adoptive cell therapy with tumor infiltrating lymphocytes (TIL) yields 50% response rates in metastatic melanoma and shows promising clinical results in other solid tumors. Autologous TIL cultures are isolated from resected tumor tissue, expanded ex vivo to large numbers and reinfused to the preconditioned patient. In this prospective study, we validate the origin of the tumor biopsy and its effect on T-cell function and clinical response. One hundred forty-four patients underwent surgery and 79 patients were treated with TIL adoptive cell therapy. Cultures from lung tissue were compared with other origins. The success rate of establishing TIL culture from lung tissue was significantly higher compared with nonlung tissue (94% vs. 72%, respectively, P≤0.003). Lung-derived TIL cultures gave rise to higher cell numbers (P≤0.011) and exhibited increased in vitro antitumor reactivity. The average fold expansion for lung-derived TIL during a rapid expansion procedure was 1349±557 compared with 1061±473 for nonlung TIL (P≤0.038). Patients treated with TIL cultures of lung origin (compared with nonlung) had prolonged median overall survival (29 vs. 9.5 mo; P≤0.065). Given the remarkable advancement in minimally invasive thoracic surgery and the results of this study, we suggest efforts should be taken to resect lung metastasis rather than other sites to generate TIL cultures for clinical use.
Manufacturing and characterisation of 3D printed thermoplastic morphing skins (2022)

Abstract Morphing aircraft are one promising solution to reducing the aviation industry’s environmental impact because they can make aircraft more aerodynamically efficient, thereby reducing greenhouse gas emissions. The design of morphing skins is inherently challenging due to the competing design constraints of needing to be stiff out-of-plane to resist pressure loads while being compliant in-plane to minimise actuation energy. Previous work by these authors introduced the novel concept of Geometrically Anisotropic Thermoplastic Rubber (GATOR) morphing skins that take advantage of multi-material 3D printing and structural scaling laws to allow for better compromises between these competing design constraints. In this work, multi material Fused Filament Fabrication methods were used to 3D print the proposed GATOR sandwich panels from two different stiffnesses of thermoplastic polyurethane to demonstrate the manufacturing process and experimentally quantify the performance of some simple embodiments of the GATOR concept. The panels were mechanically tested to determine their flexural and extensional stiffnesses. Results show that the panels can be extended to a stretch ratio of λ = 1.6 with a linear response at low stretch ratios. The results from the flexural experiments show that the flexible face sheets are capable of withstanding some compression before buckling, which results in a linear behaviour at small forces. These results show the promise of the GATOR skin concept and motivate future development of designs that further exploit the underlying principles of the concept.
Gene-set Cohesion Analysis Tool (GCAT): A literature based web tool for calculating functional cohesiveness of gene groups (2009)

Numerous algorithms exist for producing gene sets from high-throughput genomic and proteomic technologies. However, analysis of the functional significance of these groups of genes or proteins remains a big challenge. We developed a Web based system called gene-set cohesion analysis tool (GCAT) for estimating the significance level of the functional cohesion of a given gene set. The method utilizes latent semantic indexing (LSI) derived gene-gene literature similarities to determine if the functional coherence of a gene set is statistically significant compared to that expected by chance. The robustness of the method was determined by evaluating the functional cohesion for over 6000 gene ontology categories. Here, we demonstrate the utility of GCAT for analysis of microarray data from previously published experiments in which embryonic fibroblasts were treated with interferon. Using GCAT, we found the highest literature cohesion p-value (p= 1.37E-63) corresponded to a set of genes that were differentially regulated > 2-fold and had a t-test p-value <0.05, compared to genes that were only changed >2-fold (literature p-value=2.2E-44) or had a p-value <0.05 (literature p-value=6.0E-32). As a control, genes that were changed less than 2-fold or had a p-value >0.05 did not show a significant literature cohesion. These results demonstrate that GCAT can provide an objective literature-based measure to evaluate the biological significance of gene sets identified by different criterions. GCAT is available at http://motif.memphis.edu/gcat/.
[A case of total intravenous anesthesia with propofol, fentanyl and ketamine for lateral segmentectomy of the liver under pringle maneuver]. (1999)

We successfully anesthetized an 80-year-old female for Pringle maneuver which was applied at the time of liver transection and consisted of cross-clamping the hepatoduodenal ligament for 25 minutes and releasing the clamp for 2 minutes until the completion of the liver transection. Anesthesia chosen was total intravenous anesthesia with propofol, fentanyl and ketamine (PFK) in combination with epidural anesthesia. The plasma concentrations of propofol at pre-, intra-, and post-Pringle maneuver under the intravenous infusion of propofol at 3 mg.kg-1.h-1 were 0.84, 1.49, and 1.29 micrograms.ml-1, respectively. All operative procedures were done uneventfully and recovery from anesthesia was prompt after the end of propofol infusion. Transient increases in liver enzymes were seen during early postoperative period, but no signs of hepatic failure were observed. In this patient, PFK anesthesia was useful and safe for the liver transection with Pringle maneuver.