gebhart/patrepeval huggingface dataset:
Microgrid Service Restoration: The Role of Plugged-in Electric Vehicles (2013)

The development of the microgrid (MG) concept endows distribution networks with increased reliability and resilience and offers an adequate management and control solution for massive deployment of microgeneration and electric vehicles (EVs). Within an MG, local generation can be exploited to launch a local restoration procedure following a blackout. EVs are flexible resources that can also be actively included in the restoration procedure, thus contributing to the improvement of MG operating conditions. The feasibility of MG service restoration, including the active participation of EVs, is demonstrated in this article through extensive numerical simulation and experimentation in a laboratorial setup.
Introduction (2012)

The original idea for this book was for a single-authored volume by a singer, giving a broad historical overview of singing in a global context. One of the anonymous readers of the proposal for Cambridge University Press gently suggested that this might be rather a lot for one person to undertake, and sure enough, several missed deadlines later the project morphed into a book with two authors: one a specialist in Western singing and the other in non-Western music.
Functional dissection of a mouse ribosomal protein promoter: significance of the polypyrimidine initiator and an element in the TATA-box region. (1990)

All of the mammalian ribosomal protein (rp) genes examined to date initiate transcription with high precision despite the fact that they do not contain a well-defined TATA box. The initiation sites are situated within polypyrimidine tracts that are flanked by both upstream and intragenic promoter elements. In the TATA-box region of each rp promoter, there is a functionally critical element with nuclear factor binding specificity that is distinct from that of a conventional TATA box. To understand how the various elements contribute to rp promoter function, we have used site-specific mutagenesis-transfection protocols and factor binding analyses to evaluate the significance of the polypyrimidine initiator and the TATA-box counterpart for efficient and accurate transcription of the rpS16 gene. Our results indicate (i) that the polypyrimidine initiator sequence critically defines the position of the transcriptional start site, whereas a much less specific sequence is sufficient to satisfy the efficiency requirement; (ii) that an uninterrupted stretch of pyrimidines in the initiator region is not necessary for efficient transcription of rpS16 gene; and (iii) that the TATA-box counterpart or even a substituted conventional TATA box primarily influences promoter efficiency. The great diversity of promoter design, which is becoming evident as more RNA polymerase II promoters are being carefully dissected, suggests that the requirements for building a functional initiation complex may be much more flexible than was previously appreciated.
Sympathetic Activity and Essential Hypertension (1973)

1. In thirty-one patients with essential hypertension there was a close relationship between resting diastolic blood pressure and basal plasma noradrenaline levels (r = 0.729, P&lt;O.001). 2. After ganglionic blockade there was a highly significant correlation between change in resting blood pressure and change in plasma noradrenaline (r = 0.813, P&lt;0*001). 3. Patients with the highest resting blood pressure had the largest falls in blood pressure and plasma noradrenaline. 4. These results suggest that the level of the blood pressure in essential hypertension is at least in part due to excess of sympathetic activity.
Program Slicing (1984)

Program slicing is a method for automatically decomposing programs by analyzing their data flow and control flow. Starting from a subset of a program's behavior, slicing reduces that program to a minimal form which still produces that behavior. The reduced program, called a ``slice,'' is an independent program guaranteed to represent faithfully the original program within the domain of the specified subset of behavior. Some properties of slices are presented. In particular, finding statement-minimal slices is in general unsolvable, but using data flow analysis is sufficient to find approximate slices. Potential applications include automatic slicing tools for debuggng and parallel processing of slices.
Issues and challenges of propagation studies for mobile networks (2002)

Propagation measurements and models are not only important for the proper design of mobile networks, hut also for the simulation of communications systems. The state-of-art is reviewed for path loss results in outdoor and indoor environments, including penetration issues. The physical understanding of the phenomena is stressed. Similarly, wideband issues are discussed, as well as adaptive arrays, which indicate some new areas of propagation research.
Antimycin A: Stimulation of Cell Division and Protein Synthesis in Tetrahymena pyriformis (1970)

Addition of antimycin A to a culture of Tetrahymena pyriformis caused an increase in cell division and protein synthesis in this ciliated protozoan. The antimycin effect is a function of the time of exposure to the antibiotic as well as of the age of the culture. A large accumulation of endoplasmic reticulum, reflecting increased protein synthesis, was visualized by electron microscopy in cells stimulated by the antimycin A.
The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target (2014)

Numerous eukaryotic replication factors have served as chemotherapeutic targets. One replication factor that has largely escaped drug development is the Mcm2-7 replicative helicase. This heterohexameric complex forms the licensing system that assembles the replication machinery at origins during initiation, as well as the catalytic core of the CMG (Cdc45-Mcm2-7-GINS) helicase that unwinds DNA during elongation. Emerging evidence suggests that Mcm2-7 is also part of the replication checkpoint, a quality control system that monitors and responds to DNA damage. As the only replication factor required for both licensing and DNA unwinding, Mcm2-7 is a major cellular regulatory target with likely cancer relevance. Mutations in at least one of the six MCM genes are particularly prevalent in squamous cell carcinomas of the lung, head and neck, and prostrate, and MCM mutations have been shown to cause cancer in mouse models. Moreover various cellular regulatory proteins, including the Rb tumor suppressor family members, bind Mcm2-7 and inhibit its activity. As a preliminary step toward drug development, several small molecule inhibitors that target Mcm2-7 have been recently discovered. Both its structural complexity and essential role at the interface between DNA replication and its regulation make Mcm2-7 a potential chemotherapeutic target.
2P1-D06 Piezoelectric polymer flexible displacement sensor for soft actuators(Mechanism and Control for Actuator(3)) (2012)

This research aims to realize a flexible displacement detection sensor that can be attached on flexible soft bellows actuators. The sensor material is piezoelectric polymer: poly(vinylidene fluoride-trifluoroethylene) [P(VDF/TrFE)]. By adjusting temperature and applied voltage in the process of polarization, fabrication conditions were optimized. In addition, the piezoelectric polymer sensor was mounted to the actuator having a bellows structure. A flexible substrate was used as wiring in order to keep flexibility. The actuator is curved by using a negative pressure. As a result, we have confirmed the detection of actuator displacement by the sensor.
The effect of different carbohydrates on the efficiency of energy utilisation in broiler chickens (2003)

Two experiments were conducted to quantify the efficiency of utilisation of TME for carcass energy retention in broiler chickens when different proportions of wheat and barley were fed and to examine whether changing the digesta viscosity of broiler chickens (by the addition of guar gum) affected their efficiency of energy retention. In experiment 1, five dietary treatments were prepared by blending the wheat and barley in the following ratios respectively, 4:0, 3:1, 2:2, 1:3and 0:4. TME was determined in adult cockerels and the efficiency of energy retention was determined in broiler chickens from 7 to 21d of age. Experiment 2 compared the efficiency of energy retention between a sample of maize and the maize sample with 10g/kg added guar gum. Increasing levels of wheat, in substitution for barley, tended to increase (P>0.05) the efficiency of utilisation of TME for carcass energy retention. The broiler chickens fed the maize-based guar gum treatment had a lower weight gain (P < 0.001) and their retained energy per kg of added maize was markedly reduced (P < 0.001). The experiments have demonstrated the large effect that digesta viscosity can have on the efficiency of energy utilisation in broiler chickens.
Interactions of atropine with heterologously expressed and native α3 subunit‐containing nicotinic acetylcholine receptors (2003)

(1) Atropine, a classical muscarinic antagonist, has been reported previously to inhibit neuronal nicotinic acetylcholine receptors (nAChRs). In the present study, the action of atropine has been examined on alpha3beta4 receptors expressed heterologously in Xenopus oocytes and native nAChRs in medial habenula neurons. (2) At concentrations of atropine often used to inhibit muscarinic receptors (1 micro M), responses induced by near-maximal nicotine concentrations (100 micro M) at negative holding potentials (-65 mV) are inhibited (14-30%) in a reversible manner in both alpha4 and alpha3 subunit-containing heteromeric nAChRs. Half-maximal effective concentrations (IC(50) values) for atropine inhibition are similar for the four classes of heteromeric receptors studied (4-13 micro M). (3) For alpha3beta4 nAChRs in oocytes, inhibition by atropine (10 micro M) is not overcome at higher concentrations of agonist, and is increased with membrane hyperpolarization. These results are consistent with non-competitive antagonism--possibly ion channel block. (4) At low concentrations of both nicotine (10 micro M) and atropine (<10 micro M), potentiation ( approximately 25%) of alpha3beta4 nAChR responses in oocytes is observed. The relative balance between potentiation and inhibition is dependent upon membrane potential. (5) In rat medial habenula (MHb) neurons, atropine (0.3-3.0 micro M) inhibited nicotine-induced responses in both a concentration and membrane potential-dependent manner (at -40 mV, IC(50)=4 micro M), similar to the effects on alpha3beta4-nAChRs in oocytes. However, unlike heterologously expressed receptors, potentiation was barely detectable at depolarized membrane potentials using low concentrations of nicotine (3-10 micro M). Conversely, the weak agonist, choline (1-3 mM) was observed to augment responses of MHb nAChRs.
STAT3 regulated ARF expression suppresses prostate cancer metastasis (2015)

Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit. Here we show that genetic inactivation of Stat3 or IL-6 signalling in a Pten-deficient PCa mouse model accelerates cancer progression leading to metastasis. Mechanistically, we identify p19(ARF) as a direct Stat3 target. Loss of Stat3 signalling disrupts the ARF-Mdm2-p53 tumour suppressor axis bypassing senescence. Strikingly, we also identify STAT3 and CDKN2A mutations in primary human PCa. STAT3 and CDKN2A deletions co-occurred with high frequency in PCa metastases. In accordance, loss of STAT3 and p14(ARF) expression in patient tumours correlates with increased risk of disease recurrence and metastatic PCa. Thus, STAT3 and ARF may be prognostic markers to stratify high from low risk PCa patients. Our findings challenge the current discussion on therapeutic benefit or risk of IL-6/STAT3 inhibition.
On the difference of cardiorespiratory synchronisation and coordination (2017)

Cardiorespiratory phase synchronisation (CRS) is a type of cardiorespiratory coupling that manifests through a prediliction for heart beats to occur at specific points relative to the phase of the respiratory cycle. It has been under investigation for nearly 20 years, and while it seems to be mostly occurring in relaxed states such as deep sleep and anesthesia, no clear clinical implications have been established. Cardiorespiratory coordination (CRC) is a recent development in this field where the relationship between the respiratory onset and heart beat is analysed in the time domain and the possible relationship of each heart beat is considered for both the previous and the next respiratory onset. This ostensibly closely related effect must not only show relevant information content but also do so independent of CRS in order to be relevant for future studies. In this paper, we investigate CRC and its relation to CRS mainly using graphical and statistical methods on two exemplary datasets: measurements from a pregnant woman participating in a preeclampsia study and those from a man suffering from sleep apnea. We show fundamental differences between the results of both approaches and are able to show a formerly unknown dependency between the heart activity and respiratory rate, potentially indicating heartbeat-initiated inspiration. Despite their differences, methods developed for the quantification of CRS can be adapted to CRC. Completing the comparison is an investigation into the relationship between CRC and respiratory sinus arrhythmia. Similar to previous results for CRS, the two effects are found to be orthogonal, meaning that they can be observed independently or in conjunction.
Dissection of H-2Db-restricted cytotoxic T-lymphocyte epitopes on simian virus 40 T antigen by the use of synthetic peptides and H-2Dbm mutants (1990)

Five distinct cytotoxic T-lymphocyte (CTL) recognition sites were identified in the simian virus 40 (SV40) T antigen by using H-2b cells that express the truncated T antigen or antigens carrying internal deletions of various sizes. Four of the CTL recognition determinants, designated sites I, II, III, and V, are H-2Db restricted, while site IV is H-2Kb restricted. The boundaries of CTL recognition sites I, II, and III, clustered in the amino-terminal half of the T antigen, were further defined by use of overlapping synthetic peptides containing amino acid sequences previously determined to be required for recognition by T-antigen site-specific CTL clones by using SV40 deletion mutants. CTL clone Y-1, which recognizes epitope I and whose reactivity is affected by deletion of residues 193 to 211 of the T antigen, responded positively to B6/PY cells preincubated with a synthetic peptide corresponding to T-antigen amino acids 205 to 219. CTL clones Y-2 and Y-3 lysed B6/PY cells preincubated with large-T peptide LT220-233. To distinguish further between epitopes II and III, Y-2 and Y-3 CTL clones were reacted with SV40-transformed cells bearing mutations in the major histocompatibility complex class I antigen. Y-2 CTL clones lysed SV40-transformed H-2Dbm13 cells (bm13SV) which carry several amino acid substitutions in the putative antigen-binding site in the alpha 2 domain of the H-2Db antigen but not bm14SV cells, which contain a single amino acid substitution in the alpha 1 domain. Y-3 CTL clones lysed both mutant transformants. Y-1 and Y-5 CTL clones failed to lyse bm13SV and bm14SV cells; however, these cells could present synthetic peptide LT205-219 to CTL clone Y-1 and peptide SV26(489-503) to CTL clone Y-5, suggesting that the endogenously processed T antigen yields fragments of sizes or sequences different from those of synthetic peptides LT205-219 and SV26(489-503).
Mechanical Stress on Suspended Cortical Bone Sample by Low Frequency Magnetic Field (2016)

Low-frequency (LF), low-amplitude alternating current (ac) magnetic fields are approved by the U.S. Food and Drug Administration as an adjunct to the orthopedic surgery procedure (spinal fusion surgery) and for the treatment of selected bone healing complications (fracture non-union). The biological effects are understood to rely on a contact-less induction of electric currents in the electrically conducting compartments of the bone. Here, we investigate another potential mechanism of the LF magnetic field effect on bone by measuring mechanical force on bone due to its diamagnetic susceptibility. The biological rationale is the bone's exquisite sensitivity to local mechanical stresses that determine its structure and physiology. Thus, the periodic magnetic microstress effects on bone over an extended period of the typical clinical LF magnetic field application (hours daily over a period of a few months) could contribute to bone regeneration. The aim was to demonstrate the diamagnetic field effect on thin, human cortical bone slice preparations (from commercial tissue repository) suspended in the vicinity of a rotating cylindrical, diametrically magnetized permanent magnet. The data provide a basis for the calculation of diamagnetic microstresses generated by the clinical LF magnetic field stimulation devices and their significance as potential contributing factors to the biological mechanism of action of LF ac magnetic fields.
De novo design of allosteric proteins (2023)

Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.
Left ventricular thrombosis after blunt chest trauma. (2001)

A 22-year-old man was admitted to our observation with left ventricular thrombus arising after blunt chest trauma occurring during a ski accident one year before. None was obtained from a review of instrumental and laboratory data at trauma time. Transesophageal echocardiography showed an intraventricular thrombus and severe hypokinesia at the apex. Standard cardiac surgery procedure was performed and postoperative period was uneventful. Echocardiography controls at 6/12 months showed a normal apex kinesia. This case shows the importance of hospitalization, hemodynamics monitorization and late serial echocardiographic controls for timely diagnosis and management of myocardial contusion and consecutive ventricular thrombus formation to prevent life-threatening complications.
Macromolecular Delivery into Skin Using a Hollow Microneedle (2010)

The objective of the present study was to obtain information to develop an effective delivery device regarding a sophisticated hollow microneedle array-patch system. Thus, the potential of hollow microneedles was investigated for enhancing the transdermal delivery of hydrophilic large molecular compounds, and the effect of variable parameters on drug release behavior was determined from skin. Fluorescein isothiocyanate (FITC)-dextrans (4.3 kDa), FD-4, was used as the main model compound, and it was successfully loaded into the lower epidermis as well as the superficial dermis of the skin in hairless rats by a hollow microneedle. The higher the volume of FD-4 solution injected, the faster the FD-4 release rate from skin. In addition, release rate tended to increase when FD-4 was administered dividedly by multiple injections. These release profiles of FD-4 were expressed by Fick's law of diffusion. Furthermore, a combination of the formulation strategy and hollow microneedle-assisted delivery was useful for controlling the drug release rate from skin. Release profiles from drug-loaded skin were also compared by changing the molecular weights of model compounds. The larger molecular size of compounds caused a lower release rate from skin. These results suggest the utilization of hollow microneedle to enhance transdermal delivery of large molecular compounds and provide useful information for designing an effective hollow microneedle system.
Polarized ketene dithioacetals. 28. A new general highly stereoselective and regiospecific method for homologation of ketones to .alpha.,.beta.-unsaturated esters via .alpha.-oxoketene dithioacetals (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolarized ketene dithioacetals. 28. A new general highly stereoselective and regiospecific method for homologation of ketones to .alpha.,.beta.-unsaturated esters via .alpha.-oxoketene dithioacetalsBekington Myrboh, Hiriyakkanavar Ila, and Hiriyakkanavar JunjappaCite this: J. Org. Chem. 1983, 48, 26, 5327–5332Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/jo00174a032https://doi.org/10.1021/jo00174a032research-articleACS PublicationsRequest reuse permissionsArticle Views574Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direitos humanos e saúde: 70 anos após a Declaração Universal dos Direitos Humanos (2018)

A presente nota apresenta a discussão sobre a Declaração Universal dos Direitos Humanos desde sua assinatura em 1948, questionando a sua efetividade na luta por direitos e reconhecendo suas falhas ao que se refere a igualdade entre os sujeitos. Dessa forma ressalta os apagamentos que se escondem por trás de uma dita “universalidade” e reivindica a necessidade do debate, primeiramente, por dignidade – conceito que se torna inseparável do que se entende de fato por Direitos.
Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice (2014)

We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)-induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this study investigated the potential involvement of proinflammatory cytokines/chemokines in the effect of Am80 on ICH. ICH induced by collagenase injection into mouse striatum caused prominent upregulation of mRNAs for interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6, CXCL1, CXCL2, and CCL3. We found that dexamethasone (DEX) and Am80 differently modulated the increase in expression of these cytokines/chemokines; TNF-α expression was attenuated only by DEX, whereas CXCL2 expression was attenuated only by Am80. Expression of IL-1β and IL-6 was inhibited both by DEX and Am80. Neurological assessments revealed that Am80, but not DEX, significantly alleviated motor dysfunction of mice after ICH. From these results, we suspected that CXCL2 might be critically involved in determining the extent of motor dysfunction. Indeed, magnetic resonance imaging-based classification of ICH in individual mice revealed that invasion of hematoma into the internal capsule, which has been shown to cause severe neurological disabilities, was associated with higher levels of CXCL2 expression than ICH without internal capsule invasion. Moreover, a CXCR1/2 antagonist reparixin ameliorated neurological deficits after ICH. Overall, suppression of CXCL2 expression may contribute to the beneficial effect of Am80 as a therapeutic agent for ICH, and interruption of CXCL2 signaling may provide a promising target for ICH therapy.