gebhart/patrepeval huggingface dataset:
Interphase FISH screening for the LCR-mediated common rearrangement of isochromosome 17q in primary myelofibrosis (2005)

Non-allelic homologous recombination (NAHR) between low-copy repeats (LCRs) has been implicated recently in somatic rearrangements including isochromosome i(17q), which is associated with hematologic malignancies as well as solid tumors. In hematological malignancies, the most common i(17q) breakpoint results from LCR-mediated NAHR, which creates a dicentric chromosome, idic(17)(p11.2). We report an elderly patient who presented with primary myelofibrosis (MF) with myeloid metaplasia (MMM), associated with idic(17)(p11.2) as the sole chromosomal abnormality, making this the first idic(17)(p11.2) myeloproliferative case reported in which the breakpoints are mapped to the breakpoint cluster region in proximal 17p. The rearrangement breakpoint maps to the previously defined LCR cluster, further suggesting that the genomic architecture of proximal 17p may be responsible for the formation of the majority of i(17q) cases. We describe our development of a rapid screening test using interphase FISH to detect idic(17)(p11.2), discuss the potential prognostic value of this molecular diagnostic test, and examine the relevance of LCR-mediated NAHR to common rearrangements in neoplasms.
Advanced Heat Treatments for Ferrous Alloys (2013)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The performance of steel and ductile iron can be improved through a deformation process called transformation induced plasticity (TRIP). New combinations of chemistry and heat treatment to produce microstructures that exhibit TRIP are still being developed. This paper reviews the development of advanced heat treatment cycles (conventional austempering and intercritical austempering) and the resulting properties for a variety of section sizes and steel &amp;amp; ductile iron chemistries.&lt;/div&gt;&lt;/div&gt;
An Outcome Test of Discrimination for Ranked Lists (2022)

This paper extends Becker [3]’s outcome test of discrimination to settings where a (human or algorithmic) decision-maker produces a ranked list of candidates. Ranked lists are particularly relevant in the context of online platforms that produce search results or feeds, and also arise when human decisionmakers express ordinal preferences over a list of candidates. We show that non-discrimination implies a system of moment inequalities, which intuitively impose that one cannot permute the position of a lower-ranked candidate from one group with a higher-ranked candidate from a second group and systematically improve the objective. Moreover, we show that that these moment inequalities are the only testable implications of non-discrimination when the auditor observes only outcomes and group membership by rank. We show how to statistically test the implied inequalities, and validate our approach in an application using data from LinkedIn.1
1.5 µm Broadband Amplification by Tellurite-Based EDFAs (1997)

It is very important to broaden the gain bandwidth of Er3+-doped fiber amplifiers (EDFAs) in order to increase the transmission capacity of wavelength-division-multiplexing (WDM) transmission systems in the 1.5 µm band.
Preliminary study highlights the potential of immune checkpoint inhibitors in sarcomatoid mesothelioma (2020)

High proportions of T lymphocytes and CD45RO<sup>+</sup> cells were associated with prolonged mPFS and mOS in sarcomatoid patients treated with ICI immunotherapy. These data support the expansion of trials utilizing single and combination ICIs as first-line therapy in sarcomatoid MPM and warrants further studies testing the impact or detriment of chemotherapy pre-ICI.
High Resolution Simulation of Full Aircraft Control at Flight Reynolds Numbers (2006)

This paper documents some of the early results of a three year project to develop a computational method for accurately determining static and dynamic stability and control characteristics of fighter and transport aircraft with various weapons configurations as well as the aircraft response to pilot input. In this first year of the project computational data is gathered for a rigid F-16 with no control surface movement in forced motion that approximates flight test maneuvers and wind-tunnel testing techniques. The data is then post-processed to determine the resulting static and dynamic stability characteristics. Static and rigid body motion simulations of the blended wing body bomber/transport concept are performed and compared to detailed experimental data to validate the numerical approach. The main benefits of this effort are: 1) early discovery of complex aerodynamic phenomena that are typically only present in dynamic flight maneuvers and therefore not discovered until flight test, and 2) rapid generation of an accurate aerodynamic database to support aircraft and weapon certification by reducing required flight test hours and complementing current stability and control testing
Photodegradation of 4''-(epimethylamino)-4''-deoxyavermectin B1a thin films on glass (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotodegradation of 4''-(epimethylamino)-4''-deoxyavermectin B1a thin films on glassWilliam F. Feely, Louis S. Crouch, Byron H. Arison, William J. A. VandenHeuvel, Lawrence F. Colwell, and Peter G. WislockiCite this: J. Agric. Food Chem. 1992, 40, 4, 691–696Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/jf00016a034https://doi.org/10.1021/jf00016a034research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Channel engineering using B/sub 10/H/sub 14/ ion implantation for low Vth and high SCE immunity of buried-channel PMOSFETs in 4-Gbit DRAMs and beyond (2002)

Below the sub-0.25-/spl mu/m technology range, surface-channel (SC) PMOSFETs employing p+ poly-Si gates are widely used instead of buried-channel (BC) PMOSFETs employing n+ poly-Si gates. However, there are still many advantages of using an n+ poly-Si gate such as the absence of the undesirable Vth shift due to boron penetration through the gate oxide, no gate-dopant cross-diffusion, and process simplicity. The critical issues for extending the use of buried-channel PMOSFETs below the sub-0.25-/spl mu/m technology range, that is, the 4-Gbit DRAM era and beyond, are low Vth and also the suppression of short-channel effects (SCE), which can be achieved by an extremely shallow counter-doped layer with a high impurity concentration. Here, for the first time, we use decaborane (B/sub 10/H/sub 14/) ion implantation to fabricate a 20-nm-thick counter-doped layer and demonstrate an SCE-free high performance O.18-/spl mu/m BC-PMOSFET.
The role of GFAP and vimentin in learning and memory (2019)

Intermediate filaments (also termed nanofilaments) are involved in many cellular functions and play important roles in cellular responses to stress. The upregulation of glial fibrillary acidic protein (GFAP) and vimentin (Vim), intermediate filament proteins of astrocytes, is the hallmark of astrocyte activation and reactive gliosis in response to injury, ischemia or neurodegeneration. Reactive gliosis is essential for the protective role of astrocytes at acute stages of neurotrauma or ischemic stroke. However, GFAP and Vim were also linked to neural plasticity and regenerative responses in healthy and injured brain. Mice deficient for GFAP and vimentin (GFAP-/-Vim-/-) exhibit increased post-traumatic synaptic plasticity and increased basal and post-traumatic hippocampal neurogenesis. Here we assessed the locomotor and exploratory behavior of GFAP-/-Vim-/- mice, their learning, memory and memory extinction, by using the open field, object recognition and Morris water maze tests, trace fear conditioning, and by recording reversal learning in IntelliCages. While the locomotion, exploratory behavior and learning of GFAP-/-Vim-/- mice, as assessed by object recognition, the Morris water maze, and trace fear conditioning tests, were comparable to wildtype mice, GFAP-/-Vim-/- mice showed more pronounced memory extinction when tested in IntelliCages, a finding compatible with the scenario of an increased rate of reorganization of the hippocampal circuitry.
Validity of cubic law for fluid flow in a deformable rock fracture. Technical information report No. 23 (1979)

The validity of the cubic law for laminar flow of fluids through open fractures consisting of parallel planar plates has been established by others over a wide range of conditions with apertures ranging down to a minimum of 0.2 ..mu..m. The law may be given in simplified form by Q/..delta..h = C(2b)/sup 3/, where Q is the flow rate, ..delta..h is the difference in hydraulic head, C is a constant that depends on the flow geometry and fluid properties, and 2b is the fracture aperture. The validity of this law for flow in a closed fracture where the surfaces are in contact and the aperture is being decreased under stress has been investigated at room temperature using homogeneous samples of granite, basalt, and marble. Tension fractures were artifically induced and the laboratory setup used radial as well as straight flow geometries. Apertures ranged from 250 ..mu..m down to 4 ..mu..m. The cubic law was found to be valid whether the fracture surfaces were held open or were being closed under stress, and the results are not dependent on rock type. Permeability was uniquely defined by fracture aperture and was independent of the stress history used in these investigations. The effects of deviations from the ideal parallel plate concept only cause an apparent reduction in flow and may be incorporated into the cubic law by replacing C by C/f. The factor f varied from 1.04 to 1.65 in these investigations. The model of a fracture that is being closed under normal stress is visualized as being controlled by the strength of the asperities that are in contact. These contact areas are able to withstand significant stresses while maintaining space for fluids to continue to flow as the fracture aperture decreases. The controlling factor is the magnitude of the aperture and since flow depends on (2b)/sup 3/, a slight change in aperture evidently can easily dominate any other change in the geometry of the flow field.
Geometrical Structures of Partially Oxidized Rhodium Cluster Cations, Rh6Om+ (m = 4, 5, 6), Revealed by Infrared Multiple Photon Dissociation Spectroscopy (2016)

Infrared multiple photon dissociation (IRMPD) spectra of Rh<sub>6</sub>O<sub>m</sub><sup>+</sup> (m = 4-10) are obtained in the 300-1000 cm<sup>-1</sup> spectral range using the free electron laser for infrared experiments (FELIX) via dissociation of Rh<sub>6</sub>O<sub>m</sub><sup>+</sup> or Rh<sub>6</sub>O<sub>m</sub><sup>+</sup>-Ar complexes. The spectra are compared with the calculated spectra of several stable geometries obtained by density functional theory (DFT) structural optimization. The spectrum for Rh<sub>6</sub>O<sub>4</sub><sup>+</sup> shows prominent bands at 620 and 690 cm<sup>-1</sup> and is assigned to a capped-square pyramidal Rh atom geometry with three bridging O atoms and one O atom in a hollow site. Rh<sub>6</sub>O<sub>5</sub><sup>+</sup> displays bands at 460, 630, 690, and 860 cm<sup>-1</sup> and has a prismatic Rh geometry with three bridging O atoms and two O atoms in a hollow site. Rh<sub>6</sub>O<sub>6</sub><sup>+</sup> shows three intense bands around 600-750 cm<sup>-1</sup> and multiple weak bands in the range of 350-550 cm<sup>-1</sup>. This species has a prismatic Rh geometry with four bridging O atoms and two O atoms in a hollow site. Considering that Rh<sub>6</sub>O<sub>m</sub><sup>+</sup> (m ≤ 3) adopts tetragonal bipyramidal Rh<sub>6</sub> structures, the change at m = 4 to capped bipyramidal and at m = 5 to prismatic geometries results in a reduction of the number of triangular hollow sites. Since NO preferentially binds on a triangular hollow site through the N atom, the geometry change lowers the possibility of NO dissociative adsorption.
Implication of transcriptional repression in compound C-induced apoptosis in cancer cells (2013)

Compound C, a well-known inhibitor of AMP-activated protein kinase (AMPK), has been reported to induce apoptosis in some types of cells. However, the underlying mechanisms remain largely unclear. Using a DNA microarray analysis, we found that the expression of many genes was downregulated upon treatment with compound C. Importantly, compound C caused transcriptional repression with the induction of p53, a well-known marker of transcriptional stress response, in several cancer cell lines. Compound C did not induce the phosphorylation of p53 but dramatically increased the protein level of p53 similar to some other transcriptional inhibitors, including 5,6-dichloro-1-β-D-ribobenzimidazole (DRB). Consistent with previous reports, we found that compound C initiated apoptotic death of cancer cells in an AMPK-independent manner. Similar to DRB and actinomycin D (ActD), two classic transcription inhibitors, compound C not only resulted in the loss of Bcl-2 and Bcl-xl protein but also induced the phosphorylation of eukaryotic initiation factor-alpha (eIF2α) on Ser51. Hence, the phosphorylation of eIF2α might be a novel marker of transcriptional inhibition. It is noteworthy that compound C-mediated apoptosis of cancer cells is correlated with decreased expression of Bcl-2 and Bcl-xl and the phosphorylation of eIF2α on Ser51. Remarkably, compound C exhibits potent anticancer activities in vivo. Taken together, our data suggest that compound C may be an attractive candidate for anticancer drug development.
Graphical Excellence (2014)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTGraphical ExcellencePrashant Kamat, Gregory V. Hartland, and George C. SchatzView Author Information University of Notre Dame, Notre Dame, Indiana 46556, United States University of Notre Dame, Notre Dame, Indiana 46556, United States Northwestern University, Evanston, Illinois 60208, United StatesCite this: J. Phys. Chem. Lett. 2014, 5, 12, 2118–2120Publication Date (Web):June 19, 2014Publication History Published online19 June 2014Published inissue 19 June 2014https://pubs.acs.org/doi/10.1021/jz500997ehttps://doi.org/10.1021/jz500997eeditorialACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views33022Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (455 KB) Get e-AlertscloseSUBJECTS:Absorption,Color,Quantum mechanics,Software,Solvents Get e-Alerts
L'acceptabilité sociale : la prise en compte des déterminants sociaux dans l'analyse de l'acceptabilité des systèmes technologiques (2010)

RÉSUMÉ L’étude de l’acceptabilité renvoie à de nombreux modèles (Modèle d’acceptation des technologies : Davis, Bagozzi, &amp; Warshaw, 1989 ; P3, Pouvoir, performance, perception : Dillon &amp; Morris, 1999 ; ou encore Unified Theory of Acceptance and Use of Technology : Venkatesh, Morris, Davis, &amp; Davis, 2003) pour prédire le comportement de l’utilisateur. Dans ces modèles le poids des variables sociales pour prédire l’intention d’usage ou le comportement de l’utilisateur est variable (de .02 à .51). Cet article a pour objectif d’analyser les déterminants de cette variabilité en convoquant deux dimensions permettant de mieux cerner l’intervention des variables sociales : la prise en compte des normes descriptives et injonctives (Cialdini, Reno, &amp; Kallgren, 1990) d’une part et d’autre part la pesanteur sociale du comportement réalisé par l’utilisateur alors qu’il recourt à la technologie qu’on lui présente.
Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection — United States, October 2017 (2017)

CDC has updated its interim guidance for U.S. health care providers caring for infants with possible congenital Zika virus infection (1) in response to recently published updated guidance for health care providers caring for pregnant women with possible Zika virus exposure (2), unknown sensitivity and specificity of currently available diagnostic tests for congenital Zika virus infection, and recognition of additional clinical findings associated with congenital Zika virus infection. All infants born to mothers with possible Zika virus exposure* during pregnancy should receive a standard evaluation at birth and at each subsequent well-child visit including a comprehensive physical examination, age-appropriate vision screening and developmental monitoring and screening using validated tools (3-5), and newborn hearing screen at birth, preferably using auditory brainstem response (ABR) methodology (6). Specific guidance for laboratory testing and clinical evaluation are provided for three clinical scenarios in the setting of possible maternal Zika virus exposure: 1) infants with clinical findings consistent with congenital Zika syndrome regardless of maternal testing results, 2) infants without clinical findings consistent with congenital Zika syndrome who were born to mothers with laboratory evidence of possible Zika virus infection,<sup>†</sup> and 3) infants without clinical findings consistent with congenital Zika syndrome who were born to mothers without laboratory evidence of possible Zika virus infection. Infants in the first two scenarios should receive further testing and evaluation for Zika virus, whereas for the third group, further testing and clinical evaluation for Zika virus are not recommended. Health care providers should remain alert for abnormal findings (e.g., postnatal-onset microcephaly and eye abnormalities without microcephaly) in infants with possible congenital Zika virus exposure without apparent abnormalities at birth.
Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly (2023)

Abstract KEAP1 promotes the ubiquitin-dependent degradation of NRF2 by assembling into a CUL3-dependent ubiquitin ligase complex. Oxidative and electrophilic stress inhibit KEAP1 allowing NRF2 to accumulate for transactivation of stress response genes. To date there are no structures of the KEAP1-CUL3 interaction nor binding data to show the contributions of different domains to their binding affinity. We determined a crystal structure of the BTB and 3-box domains of human KEAP1 in complex with the CUL3 N-terminal domain that showed a heterotetrameric assembly with 2:2 stoichiometry. To support the structural data, we developed a versatile TR-FRET-based assay system to profile the binding of BTB-domain-containing proteins to CUL3 and determine the contribution of distinct protein features, revealing the importance of the CUL3 N-terminal extension for high affinity binding. We further provide direct evidence that the investigational drug CDDO does not disrupt the KEAP1-CUL3 interaction, even at high concentrations, but reduces the affinity of KEAP1-CUL3 binding. The TR-FRET-based assay system offers a generalizable platform for profiling this protein class and may form a suitable screening platform for ligands that disrupt these interactions by targeting the BTB or 3-box domains to block E3 ligase function. Graphical abstract Highlights A new crystal structure defines KEAP1 BTB and 3-box domain interactions with CUL3 KEAP1 and CUL3 form a heteromeric 2:2 complex with a K D value of 0.2 µM A generalizable TR-FRET platform enables multimodal profiling of BTB proteins The investigational drug CDDO is a partial antagonist of the KEAP1-CUL3 interaction
Controlling Radical Formation in the Photoactive Yellow Protein Chromophore (2015)

Abstract To understand how photoactive proteins function, it is necessary to understand the photoresponse of the chromophore. Photoactive yellow protein (PYP) is a prototypical signaling protein. Blue light triggers trans–cis isomerization of the chromophore covalently bound within PYP as the first step in a photocycle that results in the host bacterium moving away from potentially harmful light. At higher energies, photoabsorption has the potential to create radicals and free electrons; however, this process is largely unexplored. Here, we use photoelectron spectroscopy and quantum chemistry calculations to show that the molecular structure and conformation of the isolated PYP chromophore can be exploited to control the competition between trans–cis isomerization and radical formation. We also find evidence to suggest that one of the roles of the protein is to impede radical formation in PYP by preventing torsional motion in the electronic ground state of the chromophore.
Predictors of elderly patient discharge to alternative care facilities following major surgical operations (2011)

LaPar, Damien J. MD; Bhamidipati, Castigliano M. DO; Stukenborg, George J. PhD; Upchurch, Gilbert R. Jr MD, FACS; Jones, David R. MD, FACS; Hanks, John B. MD, FACS; Schirmer, Bruce D. MD, FACS; Kron, Irving L. MD, FACS; Ailawadi, Gorav MD, FACS Author Information
Impact of imperfect power control and channel estimation on the performance of multiuser detectors (2003)

Performance comparison of various linear multi-user and parallel interference cancellation (PIC) detectors in the presence of imperfect power control and channel estimation is studied by using both analysis and simulation. The results show that imperfect power control can even degrade the performance of a single-user detector. For suboptimal detectors, a tight power control is highly indispensable in order to achieve an excellent performance. Furthermore, the results indicate that interference cancellers can outperform linear multi-user detectors in case of imperfect power control. The conventional and partial PIC detectors are fairly sensitive to channel estimation errors, while the LMS PIC is quite robust.