gebhart/patrepeval huggingface dataset:
S2373 Achalasia and Gastroparesis: Coexisting Entities or Consequence of Therapy? (2020)

INTRODUCTION: No association has been reported between achalasia and gastroparesis despite similar pathophysiologic mechanisms and therapeutic options. A literature review shows only two reports of patients with both disorders for whom esophageal peroral endoscopic myotomy (POEM) and gastric (G-POEM) were performed. We have observed a number of patients with both conditions and question the possibility that their coexistence is not rare. We further propose a novel explanation for the increased incidence of GERD following successful treatment of achalasia. CASE DESCRIPTION/METHODS: #1 was a 66-year-old female with achalasia who underwent laparoscopic myotomy 17years ago followed by repeat posterior Heller myotomy for persistent dysphagia. She subsequently underwent POEM and the dysphagia resolved. Eight weeks later, she complained of heartburn and regurgitation. A pH DeMeester score was 107.4 (normal < 14.7). Gastric emptying study (GES) revealed 15% emptying at 4 hours. G-POEM was performed, and her reflux symptoms improved. Six months later, the patient discontinued PPI therapy (Table). #2 was a 70-year-old female with symptomatic achalasia despite pneumatic dilation. POEM was performed with resolution of dysphagia. One month later, she complained of constant regurgitation, emesis and heartburn. GES revealed delayed emptying. She underwent successful G-POEM, and her symptoms resolved. #3 was a 28-year-old female who underwent POEM for achalasia. Five months later, she began to complain of heartburn, severe nausea, and regurgitation. GES showed 44% emptying at 4 hours. GPOEM was successfully performed and her symptoms improved significantly. #4 was a 79-year-old female who underwent POEM for achalasia with a resolution of dysphagia. Two months later, she developed nausea, bloating, and regurgitation. GES showed 69% emptying at 4 hours. G-POEM was performed six months later, resulting in significant improvement in nausea and bloating. DISCUSSION: Concurrent or consecutive achalasia and gastroparesis raise the question of an alternative explanation for symptomatic GERD after POEM if the conditions either coexist or gastroparesis follow as a consequence of POEM by an unknown mechanism. In our patients, treatment of gastroparesis by G-POEM almost completely resolved reflux symptoms. Whether patients with achalasia have underlying, subclinical delayed gastric emptying is an important topic that warrants investigation and raises the question of performing GES on all patients with achalasia before or after POEM.Table 1.: Concurrent achalasia and gastroparesis patients; characteristics and treatment history before and after endoscopic myotomy. GES, gastric emptying study; GPOEM, gastric peroral endoscopic myotomy; GCSI, gastroparesis cardinal symptom index; LHM, laparoscopic Heller myotomy; PPI, proton pump inhibitors. POEM, peroral endoscopic myotomy
A system for specifying and rapidly prototyping user interfaces (1991)

This paper presents a system for rapidly prototyping user interfaces and a model for specifying them. The model represents the components, flow of control, constraints, and semantic feedback of an interface while the system allows the interface layout, dialogue, and application interface to be interactively defined, resulting in little or no programming to produce a prototype. As a user interface is prototyped, a model of the interface is maintained that represents its structure and functionality. This model can then be compiled into source code with calls to the X Windows and MOTIF libraries. The generated program can then be compiled and linked to application functions to produce an executable program. Other user interface builders only have interactive definitions of the interface layout and specify the dialogue in a programming language, thus requiring a programmer to learn yet another language. The system described here is based on a graph model instead of a programming language and allows complex sequencing, constraints, and the application interface to be defined interactively. This graph model representation also allows analysis of the interface to be made in terms of consistency and completeness of the specification.
A Novel Capsicum Gene Inhibits Host-Specific Disease Resistance to Phytophthora capsici (2013)

A novel disease resistance inhibitor gene (inhibitor of P. capsici resistance [Ipcr]), found in the chile pepper (Capsicum annuum) variety 'New Mexico Capsicum Accession 10399' (NMCA10399), inhibits resistance to Phytophthora capsici but not to other species of Phytophthora. When a highly P. capsici-resistant variety was hybridized with NMCA10399, the resultant F1 populations, when screened, were completely susceptible to P. capsici for root rot and foliar blight disease syndromes, despite the dominance inheritance of P. capsici resistance in chile pepper. The F2 population displayed a 3:13 resistant-to-susceptible (R:S) ratio. The testcross population displayed a 1:1 R:S ratio, and a backcross population to NMCA10399 displayed complete susceptibility. These results demonstrate the presence of a single dominant inhibitor gene affecting P. capsici resistance in chile pepper. Moreover, when lines carrying the Ipcr gene were challenged against six Phytophthora spp., the nonhost resistance was not overcome. Therefore, the Ipcr gene is interfering with host-specific resistance but not the pathogen- or microbe-associated molecular pattern nonhost responses.
Diffusing‐wave spectroscopy and interferometry (1994)

Abstract Diffusing‐wave spectroscopy and interferometry, the extensions of dynamic light scattering to materials which exhibit a very high degree of multiple scattering, have been used to measure the early‐time, short length scale motion of Brownian particles. The transition from “ballistic” to “diffusive” motion is observed. In very dilute samples, this transition is described very well by theories which explicitly account for the time‐dependent hydrodynamic interaction between a Brownian particle and the surrounding fluid. For particle volume fractions exceeding a few per cent, the data deviate from the theory for dilute suspensions, but exhibit a remarkable scaling with the suspension viscosity.
Near-Landauer Reversible Skyrmion Logic with Voltage-Based Propagation (2023)

Magnetic skyrmions are topological quasiparticles whose non-volatility, detectability, and mobility make them exciting candidates for low-energy computing. Previous works have demonstrated the feasibility and efficiency of current-driven skyrmions in cascaded logic structures inspired by reversible computing. As skyrmions can be propelled through the voltage-controlled magnetic anisotropy (VCMA) effect with much greater efficiency, this work proposes a VCMA-based skyrmion propagation mechanism that drastically reduces energy dissipation. Additionally, we demonstrate the functionality of skyrmion logic gates enabled by our novel voltage-based propagation and estimate its energy efficiency relative to other logic schemes. The minimum dissipation of this VCMA-driven magnetic skyrmion logic at 0 K is found to be $\sim$6$\times$ the room-temperature Landauer limit, indicating the potential for sub-Landauer dissipation through further engineering.
Up-date on the antiphospholipid syndrome. (2003)

Antiphospholipid syndrome is defined by recurrent thrombotic events and fetal losses in the presence of anti-phospholipid antibodies detectable by beta 2 glycoprotein I-dependent anti-cardiolipin and/or lupus anticoagulant assays. Thrombosis can occur in any vascular district but deep veins and cerebral arteries represent the most frequent sites. Both early and late fetal losses have been reported in women affected by the syndrome as well as pre-eclampsia. Beta 2 glycoprotein I-dependent anti-cardiolipin and lupus anticoagulant are the formal laboratory diagnostic tools; new assays appear to improve the diagnostic power, but larger validation studies are needed before accepting them on a routine basis. In spite of the improvement in our knowledge on the pathogenic mechanisms of the syndrome, the standard therapy is still based on anti-platelet or anticoagulant drugs both for vascular and obstetrical problems.
Using Ethephon for Seedhead Suppression of ‘Innovation’ Zoysiagrass (2021)

The performance of ethephon (Proxy) on seedhead suppression of ‘Innovation’ zoysiagrass was evaluated during the 2019–2020 growing season in Manhattan, KS. Treatments evaluated Proxy applied in a single autumn application at 5 fl. oz./1,000 ft2 on multiple dates between August 28 and November 26, 2019. Seedhead suppression ranged from 15% (application on November 1) to 82% (applied on September 4). Dates between September 4 and October 3 were the optimum application window for ethephon application on Innovation zoysiagrass as seedhead suppression was at least 62% with minimal turf injury occurring.
A new reduction process in fast‐atom bombardment mass spectrometry: Transformation of an azido group into an amino group (1993)

Abstract A new example of the reduction phenomenon often observed in fast‐atom bombardment mass spectrometry is described, involving the transformation of an azido group into an amino group. This reaction, noticeable with glycerol as a matrix, does not occur with m ‐nitrobenzylalcohol.
Environmental Acoustic Variability Characterization for Adaptive Sampling (2008)

Abstract : During shallow water antisubmarine warfare missions, environmental uncertainty significantly impacts Fleet asset performance. Oceanographic sensor availability, acoustic sensor coverage, and operational time limitations put constraints on efforts to observe large ocean areas. To address these challenges, NRL researchers have advanced and incorporated applied research technologies developed under several disciplines to implement an adaptive sensor placement capability that, under certain assumptions, minimizes the uncertainty in forecasted information. The technologies incorporated include ocean data quality control, rapidly nested oceanographic modeling, data assimilation, ensemble representation of uncertainty, acoustic performance modeling, and Ensemble Transform Kalman Filter (ETKF) adaptive sampling.
Characterization of cervicogenic headache (1998)

AbstractAbstractHeadache is a symptom commonly treated by physical therapies. Towards evidence based practices, these therapies are being evaluated in randomized controlled trials. Tension headache has received most attention. Logically, physical treatments of the cervical musculoskeletal system are appropriate for the management of headaches arising from neck dysfunction; that is, cervicogenic headache. There are difficulties in always selecting suitable headache patients for study and for treatment in everyday clinical practice. This review examines the characteristics of cervicogenic headache for differential diagnosis. There is considerable symptomatic overlap between cervicogenic headache and other chronic headache forms such as tension headache and migraine without aura. The symptomatic criteria for cervicogenic headache are well researched, but current physical diagnostic criteria are often non-specific and non-discriminatory. The possibilities for new physical diagnostic criteria are explored with the aim of helping the clinician and researcher to better identify the cervicogenic headache patient. These are based on current research into physical impairments in the musculoskeletal system with neck pain.Keywords: HEADACHECERVICOGENICCERVICAL SPINEDIAGNOSIS
β1,4-N-Acetylglucosaminyltransferase III potentiates β1 integrin-mediated neuritogenesis induced by serum deprivation in Neuro2a cells (2006)

Aspects of the biological significance of the bisecting N-acetylglucosamine (GlcNAc) structure on N-glycans introduced by beta1,4-N-acetylglucosaminyltransferase III (GnT-III) in Neuro2a cell differentiation are demonstrated. The overexpression of GnT-III in the cells led to the induction of axon-like processes with numerous neurites and swellings, in which beta1 integrin was localized, under conditions of serum starvation. This enhancement in neuritogenesis was suppressed by either the addition of a bisecting GlcNAc-containing N-glycan or erythroagglutinating phytohemagglutinin (E(4)-PHA), which preferentially recognizes the bisecting GlcNAc. GnT-III-promoted neuritogenesis was also significantly perturbed by treatment with a functional blocking anti-beta1 integrin antibody. In fact, beta1 integrin was found to be one of the target proteins of GnT-III, as confirmed by a pull-down assay with E(4)-PHA. These data suggest that N-glycans with a bisecting GlcNAc on target molecules, such as beta1 integrin, play important roles in the regulation of neuritogenesis.
New Method for Monitoring Pulmonary Artery Catheter Location (1991)

SANTORA, T; GANZ, W.; GOLD, J.; WITTMAN, M.; LEYERLE, B.; SWAN, H. J. G.; SHABOT, M. S. Author Information
An Investigation of the Performance of Roundabouts with Metering Signals (2008)

A major project was undertaken for VicRoads, the state transport authority in Victoria, to investigate the performance of roundabouts with metering signals in Melbourne, Australia. The research objectives included further development of analytical techniques to assess the performance of roundabouts with metering signals, and calibration and validation of these techniques for incorporation into the SIDRA INTERSECTION software. Twenty roundabouts with metering signals were considered as candidates for the project. Following site visits, five multi-lane roundabout sites were chosen for comprehensive surveys of traffic and driver behaviour at roundabouts with metering signals. The survey data included video recordings of driver gap acceptance behaviour, intersection turning movement volume counts, automated counting of circulating traffic, GPS-equipped floating car surveys, and metering signal timings. The peak 15-min intersection volumes at these sites were in the range 3268 to 5984 veh/h. Using the survey data, the entering and circulating traffic characteristics were investigated at the controlling and metered roundabout approaches. These included queue lengths, delays and queue spacing on approach roads, critical gap and follow-up headways of entering drivers, bunching and headway distribution of circulating traffic as well as circulating vehicle speeds. This paper presents various aspects of data collection, analysis, and findings of the project.
Recognition memory for emotional faces in amnestic mild cognitive impairment: An event-related potential study (2012)

This study examined the temporal course of emotional face recognition in amnestic mild cognitive impairment (aMCI). Patients and healthy controls (HC) performed a face recognition task, giving old/new responses to previously studied and novel faces displaying a negative or neutral expression. In aMCI patients, recognition accuracy was preserved for negative faces. Event-related potentials (ERPs) revealed disease-related changes in early perceptual components but not in ERP indices of explicit recognition. Specifically, aMCI patients showed impaired recognition effects for negative faces on the amplitudes of N170 and P2, suggesting deficient memory-related processing of negative faces at the stage of structural encoding and during an early recognition stage at which faces are individuated, respectively. Moreover, while a right-lateralized emotion effect specifically observed for correctly recognized faces on the amplitude of N170 was absent in aMCI, a similar emotion effect for successfully recognized faces on P2 was preserved in the patients, albeit with a different distribution. This suggests that in aMCI facilitated processing of successfully recognized emotional faces starts later in the processing sequence. Nonetheless, an early frontal old/new effect confined to negative faces and a parietal old/new effect unaffected by facial emotion were observed in both groups. This indicates that familiarity and conceptual priming processes may specifically contribute to recognition of negative faces in older adults and that aMCI patients can recruit the same retrieval mechanisms as controls, despite disease-related changes on early perceptual ERP components.
IR spectroscopy as a probe for C-H center dot center dot center dot X hydrogen bonded supramolecular synthons (2015)

Weak hydrogen bonds of the type C-H center dot center dot center dot X (X: N, O, S and halogens) have evoked considerable interest over the years, especially in the context of crystal engineering. However, association patterns of weak hydrogen bonds are generally difficult to characterize, and yet the identification of such patterns is of interest, especially in high throughput work or where single crystal X-ray analysis is difficult or impossible. To obtain structural information on such assemblies, we describe here a five step IR spectroscopic method that identifies supramolecular synthons in weak hydrogen bonded dimer assemblies, bifurcated systems, and p-electron mediated synthons. The synthons studied here contain C-H groups as hydrogen bond donors. The method involves: (i) identifying simple compounds/cocrystals/salts that contain the hydrogen bonded dimer synthon of interest or linear hydrogen bonded assemblies between the same functionalities; (ii) scanning infrared (IR) spectra of the compounds; (iii) identifying characteristic spectral differences between dimer and linear; (iv) assigning identified bands as marker bands for identification of the supramolecular synthon, and finally (v) identifying synthons in compounds whose crystal structures are not known. The method has been effectively implemented for assemblies involving dimer/linear weak hydrogen bonds in nitrobenzenes (C-H center dot center dot center dot O-NO), nitro-dimethylamino compounds (NMe2 center dot center dot center dot O2N), chalcones (C-H center dot center dot center dot O=C), benzonitriles (C-H center dot center dot center dot N C) and fluorobenzoic acids (C-H center dot center dot center dot F-C). Two other special cases of C-H center dot center dot center dot pi and N-H center dot center dot center dot pi synthons were studied in which the band shape of the C-H stretch in hydrocarbons and the N-H deformation in aminobenzenes was examined.
E6AP ubiquitin ligase mediates ubiquitin‐dependent degradation of peroxiredoxin 1 (2010)

E6-associated protein (E6AP) is a cellular ubiquitin protein ligase that mediates ubiquitylation and degradation of tumor suppressor p53 in conjunction with the high-risk human papillomavirus E6 protein. We previously reported that E6AP targets annexin A1 protein for ubiquitin-dependent proteasomal degradation. To gain a better understanding of the physiological function of E6AP, we have been seeking to identify novel substrates of E6AP. Here, we identified peroxiredoxin 1 (Prx1) as a novel E6AP-binding protein using a tandem affinity purification procedure coupled with mass spectrometry. Prx1 is a 25-kDa member of the Prx family, a ubiquitous family of antioxidant peroxidases that regulate many cellular processes through intracellular oxidative signal transduction pathways. Immunoprecipitation analysis showed that E6AP binds Prx1 in vivo. Pull-down experiments showed that E6AP binds Prx1 in vitro. Ectopic expression of E6AP enhanced the degradation of Prx1 in vivo. In vivo and in vitro ubiquitylation assays revealed that E6AP promoted polyubiquitylation of Prx1. RNAi-mediated downregulation of endogenous E6AP increased the level of endogenous Prx1 protein. Taken together, our data suggest that E6AP mediates the ubiquitin-dependent proteasomal degradation of Prx1. Our findings raise a possibility that E6AP may play a role in regulating Prx1-dependent intracellular oxidative signal transduction pathways.
Predicted and trifluoroethanol‐induced α‐helicity of polypeptides (1996)

The α-helix stabilizing solvent 2,2,2-trifluoroethanol (TFE) is frequently used as a medium for determining the average α-helicity of polypeptides by CD spectroscopy. CD spectra measured in solutions containing 10, 15, 20, 50, and 90% (vol/vol) TFE are presented for 5 peptides that were selected to demonstrate possible variations in the effect of TFE concentration on the secondary structure. The analysis is extended to 6 further peptides whose CD spectra as measured in TFE are documented in the literature. The observed α-helicity at a high TFE concentration is compared with the α-helicity determined by a structure prediction method that combines conformational filtering [S. Vajda, (1993) Journal of Molecular Biology, Vol. 229, pp. 125–145], and a Monte Carlo simulation [J. Figge et al. (1993) Protein Science, Vol. 2, pp. 155 –164]. For the set of 11 peptides we find a correlation of 0.84 between the predicted [θ]222 values and the corresponding values observed by CD spectroscopy in a high concentration of TFE (p < 0.01). Although we generally find a good correlation at high TFE concentration between observed and predicted α-helicity, there are several peptides that do not follow the predicted behavior. An analysis of the TFE titration curves in one such case revealed that TFE can induce a sharp transition from a partial β-sheet conformation to an α-helical conformation as the TFE concentration is increased above a critical value. © 1996 John Wiley & Sons, Inc.
Associations of Serum Retinol, α-Tocopherol, and γ-Tocopherol with Biomarkers among Healthy Japanese Men (2014)

Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23–67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = −0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = −0.262, p = 0.021), α-tocopherol (β = −0.236, p = 0.035), and γ-tocopherol levels (β = −0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = −0.286, p = 0.008) and γ-tocopherol (β = −0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = −0.211, p = 0.032) and α-tocopherol levels (β = −0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.