gebhart/patrepeval huggingface dataset:
Development of a Novel in vitro SPF Measurement Method incorporating the UVA Photoaugmentative Effect. (1996)

SPF値と相関の高いin vitro SPF測定法を確立するためには, 紫外線の紅斑反応に関する全ての生物的な現象や影響を把握する必要がある。我々はUVBの生物作用にUVAが相乗的な作用をするという問題に着目した。FDAのOTCモノグラフ (1978) のガイドラインによって評価されたSPF値とサンスクイーン剤の透過UV値を用いたスペクトロラジオメトリックな手法によって, UVAのプロモーターとしての働きについて検証を行った。サンスクリーン剤の透過UVスペクトルに紅斑作用波長の相対的な影響を乗じた値を透過UVA値と共に解析した結果, 紅斑反応に関するUVAの光増強作用が検証された。また, この作用がUVAとUVBの相乗作用という点でUVA/UVBの比率の影響を受けることも同時に確認された。これらの解析によって得られた演算プログラムをあらゆる剤型のサンスクリーン剤に適用したところ, in vivoとin vitro SPF値の間に非常に高い相関がみられた。さらに, 紅斑反応に関する相反則が成立する領域と成立しない領域の存在が認められた。この相反則が成立しない領域では別の生物的な影響の存在が示唆された。現在まで解明されていないこれらの生物的な影響を考慮したSPF演算プログラムによって, SPF値を従来になく高い精度で, かつ高SPF領域まで予測することが可能となった。
Substrate effect on the crystal structure and ferroelectricity of low-temperature-deposited Pb(Zr, Ti)O3 thin films by metalorganic chemical vapor deposition (2003)

Tetragonal Pb(Zr0.35Ti0.65)O3 thin films were deposited at deposition temperatures ranging from 395 °C to 510 °C on (111)Pt/Ti/SiO2/Si, (111)Ir/TiO2/SiO2/Si, and (100)Ru/SiO2/Si substrates by metalorganic chemical vapor deposition. When the deposition temperature was above 415 °C, the remanent polarization (Pr) and the coercive field (Ec) were almost the same for the Pb(Zr0.35Ti0.65)O3 thin films deposited on these substrates. This means that the electrical properties were not significantly affected by the type of substrate above 415 °C. However, at 395 °C, the film deposited on the (111)Pt/Ti/SiO2/Si substrate showed a larger Pr value than those on the (111)Ir/TiO2/SiO2/Si and (100)Ru/SiO2/Si substrates. The lower crystallinity of the films deposited on the (111)Ir/TiO2/SiO2/Si and (100)Ru/SiO2/Si substrates, due to the oxidation of the Ir and Ru surfaces before starting film deposition, thwarts the attainment of good ferroelectricity.
Synthetic sex pheromone of citrus leafminer in Brazilian citrus groves (2009)

The objective of this work was to determine the best conditions of use of the synthetic sex pheromone of Phyllocnistis citrella Stainton for monitoring this species in citrus groves in northeastern Brazil. Pheromone doses (0.0, 0.1, 1, 10 and 100 μg) and longevity (1, 15, 29, 43 and 57-day-old lures) and trap height (0.5, 1.5 and 2.5 m), color (green, red, and white) and model influence on P. citrella males capture were evaluated. The doses of 10 and 100 μg of the synthetic sex pheromone - a 3:1 blend of (Z,Z,E)-7,11,13-hexadecatrienal and (Z,Z)-7,11-hexadecadienal - attracted the greatest number of P. citrella males. Traps baited with these two both dosages continued to capture P. citrella males at a comparable rate for over eight weeks in citrus groves. Although there was no significant decrease in activity of both dosages until 57 days of exposure to the environment, the higher dose, as time passed, attracted significantly more P. citrella males than the lower dose. There were no significant differences in male capture in traps with synthetic sex pheromone placed at 1.5 and 2.5 m height, wich had the better results. Trap color and model did not affect male capture.
Photoinduced surface dynamics of V3O5: visualization of autocorrelation function from light scattering data (2019)

Ultrafast transition in V3O5 shows complex dynamics of the surface autocorrelation function. Phase-retrieval algorithms with filtering of stochastic scattering component provide reconstruction of specific/hidden features of photoexcited surface.
SeMPE: Secure Multi Path Execution Architecture for Removing Conditional Branch Side Channels (2021)

One prevalent source of side channel vulnerabilities is the secret-dependent behavior of conditional branches (SDBCB). The state-of-the-art solution relies on Constant-Time Expressions, which require high programming effort and incur high performance overheads. In this paper, we propose SeMPE, an architecture support to eliminate SDBCB without requiring much programming effort while incurring low performance overheads. When a secret-dependent branch is encountered, SeMPE fetches, executes, and commits both paths of the branch, preventing the adversary from inferring secret values from the branching behavior of the program. SeMPE outperforms code generated by FaCT, a constant-time expression language, by up to 18×.
A Secure and Dependable Multi-Agent Autonomous Intersection Management (MA-AIM) System Leveraging Blockchain Facilities (2018)

Every year, traffic collisions have increased rapidly in proportion to the increase in the number of vehicles, especially at intersections. The main cause is human error in recognition and decision-making. Autonomous Vehicles (AVs) and Autonomous Intersection Management (AIM) systems represent emerging challenges. AVs can take a great deal of different actions when approaching an intersection. Several research centers are developing algorithms to solve one of the crucial aspects of autonomous driving, i.e the intersections management, trying to avoid collisions and traffic congestion. In this context, security is the main concern, due to the high exposure to data and information between Vehicle-to-Vehicle (V2V) and Vehicle-to-Intersection (V2I) communications. Blockchain and smart contracts, one of most promising technologies emerged in recent years, represent a possible solution for the existing security issues. Smart contracts are the orchestration and choreography protocols that facilitate, verify and negotiated agreement between the consenting parties participating in the Blockchain network. In this paper, we propose a Multi-Agent AIM (MA-AIM) system based on V2I/I2V communication to securely manage vehicles crossing though an intersections by leveraging Blockchain facilities. A central Intersection Manager Agent (IMA) is implemented at each intersection while each vehicle is controlled by a Driver Agent (DA).
Factors Contributing to an Accelerated Decline in Pulmonary Function in Asthma (2014)

Patients with asthma show a steeper age-related decline in pulmonary function than healthy subjects, which is often alleviated after the initiation of treatment with inhaled corticosteroids (ICS). However, there still are patients who develop irreversible airflow limitations despite receiving adequate ICS treatment. The identification of the characteristics of such patients and biomarkers of progression for airflow limitation, a functional consequence of airway remodeling, is considered important in the management of asthma. A variety of biomarkers are associated with the forced expiratory volume in 1s (FEV1) in asthma in a cross-sectional fashion. However, few biomarkers are known to reflect the decline in pulmonary function, particularly in patients with asthma who receive ICS treatment. Recently periostin, a matricellular protein that prolongs Th2/eosinophilic inflammation and reflects airway remodeling, was reported to be detected in serum. In a Kinki Hokuriku Airway disease Conference multicenter cohort study, we demonstrated that among several serum markers, high serum periostin level, particularly ≥95ng/mL, was the only marker associated with a greater annual decline in FEV1 and a decline in FEV1 of ≥30mL·yr-1. A variant (rs9603226) of the POSTN gene that encodes periostin was also involved in the frequency of a decline in FEV1 of ≥30mL·yr-1. Our results suggest that the serum periostin level is a useful marker reflecting pulmonary function decline in patients with asthma receiving ICS.
Mining Program: Bureau of Mines Oil-Shale Project, Rifle, Colorado (1948)

Report issued by the Bureau of Mines on the development of efficient mining methods for producing oil shale. Characteristics of the oil shale deposits of the Green River are presented. The results of core drilling and sampling in this area are also listed. This report includes tables, illustrations, maps, and photographs.
TOWARDS DE-GLYCATION OF SKIN - USE OF SYMBIOTIC MICROORGANISMS EXTRACTS (2016)

Age-related non-enzymatic protein glycation leads in skin to the formation and subsequent accumulation of Advanced Glycation End products (AGEs), mainly carboxymethyl-lysine (CML) and pentosidine (1). Intracellular AGEs have been shown to accumulate in dermal fibroblasts upon aging, inducing oxidative stress and resulting in cell senescence and apoptosis (1, 2). The aim of this work was to use symbiotic microorganisms extracts to detoxify skin fibroblasts from AGEs. 80 extracts were screened on primary fibroblasts (54 years old donor). The intracellular glycation level was sufficiently high to allow the detection of global AGEs and pentosidine by measuring auto-fluorescence in cell lysates without additional glycation. Following 24h cell treatment the most active extracts decreased significantly the total amounts of AGEs (– 49%) and pentosidine (– 33%). The ability of 11 highly active extracts to reduce the intracellular amount of CML in fibroblasts was then tested using immunofluorescence technique. The 3 most active extracts decreased the amount of CML by 15% in addition to global AGEs and pentosidine. Phytochemical studies through bioguided fractionation showed increased activities of fractions (CML amount -27%). Transcriptional studies are also in progress to identify a biological mechanism of AGEs degradation.
Genetic inhibition of caspase‐2 reduces hypoxic‐ischemic and excitotoxic neonatal brain injury (2011)

These data suggest for the first time a role of Casp2 in neonatal brain damage.
Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation (2016)

A successful pregnancy depends on the maintenance of tolerance at the fetal-maternal interface; strong inflammation in the placental bed is generally associated with adverse fetal outcomes. Among the mechanisms that foster tolerance and limit inflammation, the fetal immune system favors Th2 or regulatory responses over Th1 responses. The unintended consequence of this functional program is high susceptibility to infections. Human Vδ2 T cells mount innate-like responses to a broad range of microorganisms and are poised for Th1 responses before birth. In infants they likely play a key role in protection against pathogens by exerting early Th1 effector functions, improving function of other innate cells, and promoting Th1 polarization of adaptive responses. However, their propensity to release Th1 mediators may require careful regulation during fetal life to avoid exaggerated proinflammatory responses. We investigated molecules with the potential to act as a rheostat for fetal Vδ2 cells. Programmed death 1 (PD1) is a negative regulator of T cell responses and a determinant of tolerance, particularly at the fetal-maternal interface. Neonatal Vδ2 cells upregulate PD1 shortly after activation and, unlike their adult counterparts, express this molecule for at least 28 d. Engagement of PD1 by one of its ligands, PDL1, effectively dampens TCR-mediated responses (TNF-α production and degranulation) by neonatal Vδ2 cells and may thus help maintain their activity within safe limits. PD1 expression by neonatal Vδ2 cells is inversely associated with promoter DNA methylation. Prolonged PD1 expression may be part of a functional program to control Vδ2 cell inflammatory responses during fetal life.
GaAs FET device and circuit simulation in SPICE (1987)

We have developed a GaAs FET model suitable for SPICE Circuit simulations. The dc equations are accurate to about 1 percent of the maximum drain current. A simple but accurate interpolation formula for drain current as a function of gate-to-source voltage connects the square-law behavior just above pinchoff and the square-root law for larger values of the drain current. The ac equations, with charge-storage elements, describe the variation of the gate-to-source and gate-to-drain capacitances as the drain-to-source voltage approaches zero and when this voltage becomes negative. Under normal operating conditions the gate-to-source capacitance is much larger than the gate-to-drain capacitance. At zero drain-to-source voltage both capacitances are about equal. For negative drain-to-source voltages the original source acts like a drain and vice versa. Consequently the normally large gate-to-source capacitance becomes small and acts like a gate-to-drain capacitance. In order to model these effect it is necessary to realize that, contrary to conventional SPICE usage, there are no separate gate-to-source and gate-to-drain charges, but that there is only one gate Charge which is a function of gate-to-source and gate-to-drain voltages. The present treatment Of these capacitances permits simulations-in which the drain-to-source voltage reverses polarity, as occurs in pass-gate circuits.
SLAQ: Quality-Driven Scheduling for Distributed Machine Learning (2018)

Training machine learning (ML) models with large datasets can incur significant resource contention on shared clusters. This training typically involves many iterations that continually improve the quality of the model. Yet in exploratory settings, better models can be obtained faster by directing resources to jobs with the most potential for improvement. We describe SLAQ, a cluster scheduling system for approximate ML training jobs that aims to maximize the overall job quality. When allocating cluster resources, SLAQ explores the quality-runtime trade-offs across multiple jobs to maximize system-wide quality improvement. To do so, SLAQ leverages the iterative nature of ML training algorithms, by collecting quality and resource usage information from concurrent jobs, and then generating highly-tailored quality-improvement predictions for future iterations. Experiments show that SLAQ achieves an average quality improvement of up to 73% and an average delay reduction of up to 44% on a large set of ML training jobs, compared to resource fairness schedulers.
Schmerzreduktion nach Operation an der Halswirbelsäule (2005)

Patients with pain caused by discs in the cervical spine, have better improvement than patients with other pathologies. This should be taken into account when choosing the mode of therapy.
ChemInform Abstract: Synthesis, Crystal Structure and Properties of 1,3‐(Bis(N‐methyl‐2‐imidazolideneamino)propan‐2‐ol)Cu(II) Perchlorate. (1989)

Abstract The new ligand (III) is prepared and found to form a mononuclear Cu(II) complex (V) (yield not given; P1, Z=2), whose structural features resemble those proposed for the active site of galactose oxidase.
Endocrine neoplasms of the pancreas: pathologic and genetic features. (2009)

The diagnosis of PEN is generally easy, but unusual features may induce misdiagnosis. Immunohistochemistry solves the issue, provided that the possibility of a PEN has been considered. Morphology allows the distinction of poorly differentiated aggressive carcinomas from well-differentiated neoplasms. The World Health Organization classification criteria allow for the discernment of the latter into neoplasms and carcinomas with either benign or uncertain behavior. The recently proposed staging and grading systems hold great promise for permitting a stratification of carcinomas into clinically significant risk categories. To date, inactivation of the MEN1 gene remains the only ascertained genetic event involved in PEN genesis. It is inactivated in roughly one-third of PENs. The degree of genomic instability correlates with the aggressiveness of the neoplasm. Gene silencing by promoter methylation has been advocated, but a formal demonstration of the involvement of specific genes is still lacking. Expression profiling studies are furnishing valuable lists of mRNAs and noncoding RNAs that may advance further the research to discover novel markers and/or therapeutic targets.
ChemInform Abstract: 1,3‐Asymmetric Induction in Dianionic Allylation Reactions of Amino Acid Derivatives — Synthesis of Functionally Useful Enantiopure Glutamates, Pipecolates and Pyroglutamates. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Prong features detection of a 3D model based on the watershed algorithm (2004)

No abstract available.
Concentrated Pickering emulsions stabilised by hemp globulin–caseinate nanoparticles: tuning the rheological properties by adjusting the hemp globulin : caseinate ratio (2020)

Industrial hemp (Cannabis sativa L.) is an underutilised novel protein source. However, the utilisation of hemp seed protein is limited by its low solubility in water. Soluble nanoparticles were made by complexing hemp globulin (HG) with sodium caseinate (SC) via a pH-cycling method. Oil-in-water Pickering emulsions were made with these co-assembled protein nanoparticles. The emulsions were composed of 70% oil phase and 30% water phase (v/v), and contained 2% protein (w/v, pure SC or HG-SC nanoparticles with an HG : SC ratio of 1 : 2 or 1 : 1). All emulsions were stable during 21 days of storage, as there was no phase separation, coalescence or flocculation. At day 0, all emulsions were solid-like (G' > G'') regardless of the protein composition. The rheological properties of the emulsions during storage could be tuned by controlling the HG : SC ratio in the HG-SC nanoparticles, i.e. the emulsions became more solid-like over time when there was more HG in the nanoparticles. In contrast, emulsions stabilised by pure SC became more liquid-like during storage. The internal structure and interactions within the emulsions were evaluated by fitting frequency sweep test data according to a co-operative theory of flow. The result suggested that the solid-like emulsion resulted from stronger short-range interactions between flocs of oil droplets, which developed during storage when there was more HG in the HG-SC nanoparticles, and not from the formation of a three-dimensional network. These HG-SC nanoparticles can be used to control the rheological properties of an emulsion during its shelf life.
New perspectives on the nature and imaging of active site in small metallic particles: I. Geometric effects (2019)

The science of heterogeneous catalysis is primarily based on surface phenomena, which occur on the surface of nanoscale structures at sub-Å dimensions. On these surfaces, only some atomic sites which have a unsaturated valence feature (under-coordinated or coordinately unsaturated) are discerned to be the active sites, i.e., active for surface processes, including adsorption, surface reactions, and desorption. With illustrative examples from the HR-TEM studies of the Cu/ZnO/Al2O3methanol synthesis catalyst and Au/TiO2 catalyst for CO oxidation reactions, we show pictorial evidences of many of the surface discontinuities and active sites at steps, edges, and perimeter areas, as well as surface terminations and crystal planes, such as (111), (100), and (110). The principal objective of this presentation is to offer new perspectives on the nature of active site (in an ensemble of atoms/a cluster) and its electronic and geometric properties. This article is organized into 2 parts. In this part I of the Series, we offer new knowledge-based analysis of the geometric effects/properties of the nanoclusters and active sites, which are governed by a specific size (at nm scale) and shape/morphology. In part II, we will elaborate on the electronic properties which arise as a result of typical metallic to nonmetallic transition. We also introduce and discuss new and fundamental concepts such as “Brønsted–Evans–Polanyi relationships” and “volcano curves” that are used to establish a partitioning between the “electronic” and “geometric” effects. Two interrelated techniques, STEM-EELS and STXM-XAS, will be used to show the atomic-scale (sub-Å) features of these morphological properties.
Magnetic and transport properties of Mo substituted La0.67Ba0.33Mn1−xMoxO3 perovskite system (2005)

The effect of doping Mo for Mn on the magnetic and transport properties of the colossal magnetoresistance material La0.67Ba0.33MnO3 has been studied. Compounds of the series La0.67Ba0.33Mn1−xMoxO3(x=0.0–0.1) have been prepared and found to crystallize in the orthorhombic structure (space group Pbnm). Energy dispersive x-ray analysis measurements confirm the stoichiometry of all the samples. Magnetotransport and magnetization measurements reveal that the metal-insulator transition temperature (Tp) decreases from 330 K for x=0 to 255 K for x=0.1. The change in Tp on Mo substitution is relatively much smaller than the corresponding change observed on substitution by other transition elements, such as Ti, Fe, Co, Ni, etc. Further, the ferromagnetic transition temperature (TC) is nearly unchanged by Mo substitution. This is in striking contrast to the large decrease in TC observed with substitution of the above-mentioned 3d elements. These unusual magnetic and transport properties of La0.67Ba0.33Mn1−xMoxO3 may be either due to the formation of a magnetic pair between Mn and Mo or due to strong Mo(4d)–O(2p) overlap, which in turn, may affect the Mn–Mn interaction via the oxygen atoms.
Pharmacokinetics of the fetal estrogen estetrol in a multiple-rising-dose study in postmenopausal women (2017)

The pharmacokinetic profile of estetrol is characterized by a very fast absorption phase, followed by an initial rapid decline, and a slow terminal elimination phase. Based on its kinetic properties, estetrol seems suitable for use as a once-daily oral drug.
Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease (2012)

The BBB-permeable trehalose derivative (TD-G6) was found to efficiently prevent the aggregation of polyQ in the transfected HEK293 cells. Furthermore, it was also found to significantly prolong lifespan, improve motor functions, and reduce the inclusion bodies in a transgenic mouse model (Tg R6/2), when given ad libitum.
Cinnamon polyphenols regulate high‐fructose feeding and age‐induced decreases in sirtuins in rat intestinal enterocytes (2012)

Sirtuins (SIRTs) may play a role in aging, insulin sensitivity, lipid metabolism, stress responses, and inflammation. Cinnamon type A polyphenols (CPA) have also been shown to improve glucose, insulin, and lipid metabolism, and inflammation. However, little is known of the effects of CPA on the expression of SIRTs. In this study, Wistar rats were fed a fructose‐rich diet for 6 weeks to induce insulin resistance and freshly isolated intestinal enterocytes were used to investigate the effects of purified CPA in vitro on SIRTs genes by RT‐PCR and proteins by Western blot analyses. SIRT1, 2, 3, 5, and 7 gene expressions were increased by 20 and 100 μg/mL CPA after 2 and 4h treatment; SIRT1‐3 protein levels were higher in 100 μg/mL CPA‐treated enterocytes after 4h. Similar effects were observed in the small intestinal enterocytes isolated from older Wistar rats (65 wks) consuming a stock diet. These results suggest that cinnamon polyphenols may activate sirtuins in intestinal enterocytes functionally altered by diet and age (Funded by USDA CRADA No.58‐3K95‐7‐1184 with Integrity).
Proportion of Recovered Waterfowl Bands Reported (1961)

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