gebhart/patrepeval huggingface dataset:
Neurofascin antibodies in autoimmune, genetic, and idiopathic neuropathies (2017)

Neurofascin antibodies were 4 times more frequent in autoimmune neuropathy samples compared to genetic neuropathy controls. Persistent IgG4 responses to NF155 correlated with severe CIDP resistant to usual treatments but responsive to rituximab. IgG4 antibodies against the common domains shared by glial and axonal isoforms may portend a particularly severe but treatable neuropathy. The prognostic implications of neurofascin antibodies in a subset of idiopathic neuropathy patients and transient IgM responses in GBS require further investigation.
Wireless Internet applications and architecture: building professional wireless applications worldwide (2002)

Wireless Internet Applications and Architecture: Building Professional Wireless Applications Worldwide is a comprehensive technical overview of wireless Internet technology, applications, and content issues. The wireless Internet of the future will be able to serve large, specialized market segments with new devices, services, and content through wide bandwidth (MMDS, GPRS) and always-on capability, offering people the freedom to communicate in ways they never have before. Divided into three easy-to-follow parts, the book begins with an introduction to the wireless Internet, the language, and the core wireless concepts. This part examines the trends, forces, and organizations that are shaping the growth of wireless Internet technology. The next part shows how to create mobile personas and wireless applications and make them effective. The chapters here tackle how to construct messaging, browsing, and interactive and conversational voice portal applications by highlighting application code and examples of mobile content. In the final part, components of wireless architecture are described so that readers can learn about wireless WAN, LAN, and PAN standards and practices and XML server strategies, as well as the effect wireless architectural elements are having on the market. An added plus is the discussion on mCommerce servers---the next step in eCommerce---and location-based applications that enable users to make purchases from mobile devices.
Supplementary Dataset 4 from SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia (2023)

&lt;p&gt;Complete blood counts&lt;/p&gt;
Defining and providing robust controls for microRNA prediction (2012)

microRNAs are short non-coding RNAs that regulate gene expression by inhibiting target mRNA genes. Next-generation sequencing combined with bioinformatics analyses provide an opportunity to predict numerous novel miRNAs. The efficiency of these predictions relies on the set of positive and negative controls used. We demonstrate that commonly used positive and negative controls may be unreliable and provide a rational methodology with which to replace them.
Upgraded Space Debris Evolutionary Model for the Geosynchronous Earth Orbit (2012)

Space debris environment evolutionary model for the geosynchronous Earth orbit region, GEODEEM, developed by Kyushu University was upgraded for better understanding. This paper explain the key features of this upgraded model. One of keys of this upgrade is that all satellites larger than 10 cm in size are tracked individually. The benefits of this upgrade are: 1) collision accidents can be estimated based upon one-by-one collision probabilities, and 2) more realistic scenarios like removing certain objects from orbits can be applied. This paper also present the latest prediction of future space debris environment from 2008 to 2108. The model indicates that explosion is the main debris production mode in next 100 years.
Laser shock processing influence on constitutive behaviour of graded structures produced by laser welding of ferritic to austenitic stainless steel (2014)

The main objective of the present investigation was to assess the constitutive behaviour of the graded structures produced by laser shock processing (LSP) on laser welded joints made between thin sheets of ferritic and austenitic stainless steel. First, the evolution of surface strain patterns during uniaxial loading of the as welded and LSP treated joints was experimentally obtained by using a video-image correlation technique. Overall and local constitutive behaviour across the weld, heat affected zone and parent metals resulted by coupling the applied load level with the corresponding strain average of each zone. The differences found in mechanical resistance of the LSP treated zones when comparing with the as welded ones were due to the processing features, namely the generation of compressive stresses and the development of graded surface structures. Special attention was paid on changes occurred in the ferritic steel side of the joint, which acts as a mechanical cut-out fuse in structures working in energy related applications. Then, by extrapolating the fatigue fracture behaviour of macroscopic notches to the surface cavities and irregularities from which surface topography results it was found that LSP improves the ferritic steel side fatigue resistance. Additionally, the growth of eventual surface flaws is delayed by the compressive stress state induced by LSP, as indicated by in-depth X-ray measurements.
Design of the LHC US ATLAS Barrel Cryostat (2002)

One of the experiments of CERN’s Large Hadron Collider (LHC) is the ATLAS Liquid Argon detector. The Liquid Argon Barrel Cryostat is part of the United States contribution to the LHC project and its design is presented here. The device is made up of four concentric cylinders: the smallest and largest of which form a vacuum vessel enclosing a cold vessel cryostat filled with liquid argon. The Cryostat serves as the housing for an electromagnetic barrel calorimeter, supports and provides space in vacuum for a solenoid magnet while the toroidal opening furnishes room for a tracker detector. Design requirements are determined by its use in a collider experiment: the construction has to be compact, the material between the interaction region and the calorimeter has to be minimal and made of aluminum to reduce the amount of absorbing material. The design complies with code regulations while being optimized for its use in a physics environment.
Regulation of erythropoiesis in long-term hamster marrow cultures: role of bone marrow-adherent cells (1985)

The initial establishment of hamster long-term bone marrow (LTBM) cultures requires formation of an adherent stromal layer, but continued long-term proliferation of these cultures is best accomplished by removal of the suspension cells from the adherent layer and subsequent incubation in liquid suspension culture. Continued maintenance of bone marrow cells in the presence of the adherent layer for more than four to six weeks leads to a decline and eventual disappearance of erythroid and multipotent colony-forming cells. Addition of erythropoietin to LTBM suspension cultures produces mature, hemoglobinized erythrocytes. Incubation of the same cells plus erythropoietin in the presence of autologous parental adherent layers markedly inhibits both terminal erythroid differentiation and the number of detectable erythroid burst-forming units (BFU-Es). This erythroid inhibition occurs primarily within the first 24 hours with little or no effect on CFU-GEMMs or granulocyte-macrophage colony-forming units (GM-CFUs). However, continued incubation for seven days produces a reduction in all parameters. Removal of suspension cells from the adherent layer and restimulation with erythropoietin allows regeneration of erythropoiesis. Pretreatment of suspension cells with erythropoietin for 96 hours before exposure to the adherent culture only slightly inhibits erythropoiesis, suggesting that more mature erythroid progenitors are unaffected. Conditioned medium from the marrow adherent layer (ALCM) produces similar erythroid inhibitory effects in LTBM cultures with as little as two hours of incubation. The inhibition is actively produced by the adherent cells, since cycloheximide abolishes its production, while indomethacin has no apparent effect. Adherent marrow stromal cells may regulate hemopoiesis through negative as well as positive humoral signals, and they are particularly effective in erythroid regulation.
The roles of p27Kip1 and DNA damage signalling in the chemotherapy‐induced delayed cell cycle checkpoint (2010)

DNA lesions trigger the DNA damage response (DDR) machinery, which protects genomic integrity and sustains cellular survival. Increasing data underline the significance of the integrity of the DDR pathway in chemotherapy response. According to a recent work, persistent exposure of A549 lung carcinoma cells to doxorubicin induces an initial DDR-dependent checkpoint response, followed by a later DDR-independent, but p27(Kip1)-dependent one. Prompted by the above report and to better understand the involvement of the DDR signaling after chemotherapeutic stress, we examined the potential role of the canonical DDR pathway in A549 cells treated with doxorubicin. Exposure of A549 cells, prior to doxorubicin treatment, to ATM, ATR and DNA-PKcs inhibitors either alone or in various combinations, revealed that the earlier documented two-step response was DDR-dependent in both steps. Notably, inhibition of both ATM and ATR or selective inhibition of ATM or DNA-PKcs resulted in cell-cycle re-entry despite the increased levels of p27(Kip1) at all time points analyzed. We further investigated the regulation of p27(Kip1) protein levels in the particular setting. Our results showed that the protein status of p27(Kip1) is mainly determined by p38-MAPK, whereas the role of SKP2 is less significant in the doxoroubicin-treated A549 cells. Cumulatively, we provide evidence that the DNA damage signaling is responsible for the prolonged cell cycle arrest observed after persistent chemotherapy-induced genotoxic stress. In conclusion, precise identification of the molecular mechanisms that are activated during the chemotherapeutic cycles could potentially increase the sensitization to the therapy applied.
Symptoms of vocal cord paresis among children born extremely premature with- or without PDA ligation. A Norwegian national cohort study. (2018)

<b>Background:</b> Treatment of patent ductus arteriosus (PDA) in extremely preterm (EP) born infants is debated. If active measures are decided, two options are available; cyclooxygenase inhibitors or surgical ligation. The latter option is associated with verified but varying rates of left vocal cord paralysis (LVCP), causing respiratory problems often confused with other disorders such as asthma. It is unknown if LVCP leads to recognizable patterns of respiratory symptoms. <b>Objective:</b> To identify respiratory symptoms in EP-born children exposed to surgical ligation of PDA. <b>Methods:</b> This was a sub-study of all infants with a significant PDA (n=163) enrolled in a nationwide questionnaire based study of all children born EP during 1999-2000 at gestational age &lt; 28 weeks or birth weight &lt; 1000g. <b>Results:</b> Surgical ligation had been performed in 51/163 infants with PDA, leaving 112 unligated as control group. There were 91 responders, 35 ligated and 56 unligated controls. Scraping sounds during physical exercise were reported by respectively 23% vs. 7% (p=0.031), hoarseness by 23% vs. 2% (p&lt; 0.001), current asthma by 26% vs. 14% (p=0.174), asthma ever by 30% vs. 37% (p=0.503), lung disease at 5 years by 26% vs. 13% (p=0.039) and asthma medications after discharge by 69% vs. 43% (p=0.017). <b>Conclusion:</b> Children born EP with a neonatal history of surgically ligated PDA had more respiratory symptoms and used more asthma medication than comparable EP born children with a PDA that had not been surgically treated. As LVCP may pass undiagnosed in neonates, symptoms may easily be confused with asthma in later life. These children should undergo laryngoscopy.
Total synthesis of desacetylumuravumbolide, umuravumbolide and their biological evaluation (2012)

Stereoselective synthesis of naturally occurring α,β-unsaturated lactones desacetylumuravumbolide and umuravumbolide is described. Commercially available propargyl alcohol was used as the starting material. The key steps of this synthesis were alkynylation, a Noyori asymmetric reduction and Still–Gennari olefination. Additionally, the biological activity of umuravumbolides was evaluated on HeLa, MDA-MB-231, MCF7 and A549 cancer cell lines. Umuravumbolide (2) showed potent anticancer activity.
A novel validated RP-HPLC method for the estimation of canagliflozin in bulk and pharmaceutical dosage forms (2017)

The objective of the present study was to develop a simple, specific and accurate reverse phase high performance liquid chromatographic method for the determination of Canagliflozin in bulk and pharmaceutical dosage forms. The method is optimized on an inertsil ODS-3(250.6mm, 5) column with a mobile phase combination of 0.02% Formic acid: Acetonitrile (40:60) at a flow rate 1.2ml/min and the eluents were monitored at 230nm. Under these LC conditions Canagliflozin peak was eluted at 4.4 min. The developed method was validated as per ICH guidelines. The calibration curve was linear over a concentration range of 10-50g/ml (R 2 =0.999) and the mean percentage assay was found to be 98.2. The statistical data proved that proposed method is accurate, precise and reproducible. The method which is LC-MS compatible can be adopted in the routine analysis of Canagliflozin in bulk and pharmaceutical dosage forms.
Effect of Solarization andGliocladium virenson Sclerotia ofSclerotium rolfsii,Soil Microbiota, and the Incidence of Southern Blight of Tomato (1991)

Soil solarization in combination with the introduction of the fungal antagonist Gliocladium virens was evaluated as a potential disease management strategy for control of southern blight caused by Sclerotium rolfsii on tomatoes in North Carolina. Highest soil temperatures measured during the solarization period in 1988 and 1990 were 41 and 49 C, respectively, whereas maximum differences in soil temperature between plots that were solarized and plots that were not solarized were 9 C in 1988 and 14 C in 1990 (...)
A New Biodegradable Elastin-Fibrin Material; Its Use in Urological, Digestive and Cardiovascular Surgery (1992)

A new original artificial connective matrix mainly made of elastin and fibrin-like product is used to reinforce damaged tissues and to close and restore a loss of substance in several domains of surgery: all sites in the digestive system and urinary tract; besides, it can substitute for the pericardium in iterative heart operations. In all cases, the original tissue is restored ad integrum while the biodegradable material disappears completely, without any complications.
Maximum loadability of power systems using interior point nonlinear optimization method (1997)

This paper proposes a nonlinear optimization interior point (IP) method for the determination of maximum loadability in a power system. Details of the implementation of pure primal-dual and predictor-corrector primal-dual IP algorithms are presented. It is shown that most of the computational effort of the algorithm is taken by the formation and factorization of the augmented Hessian matrix of the IP algorithm. The size of this matrix can be as large as ten times the number of buses in the system. Comparisons of the two IP implementations with large scale power systems with as many as 4000 buses are presented. It is shown that the IP algorithm constitutes an effective method for the determination of the maximum loadability in a power system.
The Growth and Impact of Alzheimer Disease Centers as Measured by Social Network Analysis (2014)

The ADC program has successfully fostered high-impact, multiuniversity collaborations; we suggest that its structural and administrative features could be replicated in other fields of patient-oriented research.
A Carbon-Based Biosensing Platform for Simultaneously Measuring the Contraction and Electrophysiology of iPSC-Cardiomyocyte Monolayers (2022)

Heart beating is triggered by the generation and propagation of action potentials through the myocardium, resulting in the synchronous contraction of cardiomyocytes. This process highlights the importance of electrical and mechanical coordination in organ function. Investigating the pathogenesis of heart diseases and potential therapeutic actions <i>in vitro</i> requires biosensing technologies which allow for long-term and simultaneous measurement of the contractility and electrophysiology of cardiomyocytes. However, the adoption of current biosensing approaches for functional measurement of <i>in vitro</i> cardiac models is hampered by low sensitivity, difficulties in achieving multifunctional detection, and costly manufacturing processes. Leveraging carbon-based nanomaterials, we developed a biosensing platform that is capable of performing on-chip and simultaneous measurement of contractility and electrophysiology of human induced pluripotent stem-cell-derived cardiomyocyte (iPSC-CM) monolayers. This platform integrates with a flexible thin-film cantilever embedded with a carbon black (CB)-PDMS strain sensor for high-sensitivity contraction measurement and four pure carbon nanotube (CNT) electrodes for the detection of extracellular field potentials with low electrode impedance. Cardiac functional properties including contractile stress, beating rate, beating rhythm, and extracellular field potential were evaluated to quantify iPSC-CM responses to common cardiotropic agents. In addition, an <i>in vitro</i> model of drug-induced cardiac arrhythmia was established to further validate the platform for disease modeling and drug testing.
Lesion-to-ventricle distance and other risk factors for the persistence of newly formed black holes in relapsing–remitting multiple sclerosis (2013)

Location of BHs close to the lateral ventricles does not appear to favourably influence the resolution of new BHs in RRMS.
Three-dimensional structure of the binuclear metal center of phosphotriesterase (1995)

Phosphotriesterase, as isolated from Pseudomonas diminuta, is capable of detoxifying widely used pesticides such as paraoxon and parathion and various mammalian acetylcholinesterase inhibitors. The enzyme requires a binuclear metal center for activity. Recently, the three-dimensional structure of the apoenzyme was solved (Benning et al., 1994) and shown to consist of an alpha/beta-barrel. Here we describe the three-dimensional structure of the holoenzyme, reconstituted with cadmium, as determined by X-ray crystallographic analysis to 2.0-A resolution. Crystals employed in the investigation belonged to the space group C2 with unit cell dimensions of a = 129.5 A, b = 91.4 A, c = 69.4 A, beta = 91.9 degrees, and two subunits in the asymmetric unit. There are significant differences in the three-dimensional architecture of the apo and holo forms of the enzyme such that their alpha-carbon positions superimpose with a root-mean-square deviation of 3.4 A. The binuclear metal center is located at the C-terminus of the beta-barrel with the cadmiums separated by 3.8 A. There are two bridging ligands to the metals: a water molecule (or possibly a hydroxide ion) and a carbamylated lysine residue (Lys 169). The more buried cadmium is surrounded by His 55, His 57, Lys 169, Asp 301, and the bridging water in a trigonal bipyramidal arrangement. The second metal is coordinated in a distorted octahedral geometry by His 201, His 230, Lys 169, the bridging water molecule, and two additional solvents.
Nickel–Cadmium Batteries (2012)

This chapter contains sections titled: Introduction Operating principle Main characteristics
Just the job Funding salary costs (2010)

Shari Baker outlines how a little creativity, and attention to the language of a funding application, can open doors to previously unavailable funds.
Electronic and Optical Properties of 2D Materials Constructed from Light Atoms (2018)

Boron, carbon, nitrogen, and oxygen atoms can form various building blocks for further construction of structurally well-defined 2D materials (2DMs). Both in theory and experiment, it has been documented that the electronic structures and optical properties of 2DMs are well tunable through a rational design of the material structure. Here, the recent progress on 2DMs that are composed of B, C, N, and O elements is introduced, including borophene, graphene, h-BN, g-C<sub>3</sub> N<sub>4</sub> , organic 2D polymers (2DPs), etc. Attention is put on the band structure/bandgap engineering for these materials through a variety of methodologies, such as chemical modifications, layer number and atomic structure control, change of conjugation degree, etc. The optical properties, such as photoluminescence, thermoluminescence, single photon emission, as well as the associated applications in bioimaging and sensing, are discussed in detail and highlighted.
Alignment editing and identification of consensus secondary structures for nucleic acid sequences: interactive use of dot matrix representations (1995)

We present a computer-aided approach for identifying and aligning consensus secondary structure within a set of functionally related oligonucleotide sequences aligned by sequence. The method relies on visualization of secondary structure using a generalization of the dot matrix representation appropriate for consensus sequence data sets. An interactive computer program implementing such a visualization of consensus structure has been developed. The program allows for alignment editing, data and display filtering and various modes of base pair representation, including co-variation. The utility of this approach is demonstrated with four sample data sets derived from in vitro selection experiments and one data set comprising tRNA sequences.
Are cells from a snowman realistic? Cryopreserved tissues as a source for single-cell RNA-sequencing experiments (2017)

A recently published study in Genome Biology shows that cells isolated from cryopreserved tissues are a reliable source of genetic material for single-cell RNA-sequencing experiments.Please see related Method article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1171-9.
Einsatz eines Buschhäckslers zur Sekundärwaldnutzung in tropischen Brachesystemen (2015)

Der Einsatz der Brandrodung zur Nutzungsvorbereitung landwirtschaftlicher Nutzflächen in tropischen Agrarsystemen hat neben den bekannten ökologischen Nebenwirkungen auch erhebliche Wirkungen auf das langfristige Ertragspotential der Flächen. Die Nachhaltigkeit der Systeme scheint nur durch den Ersatz der Brandrodung durch Mulchwirtschaft zu sichern zu sein. Bislang fehlten jedoch Technologien, die den Umstieg zur Mulchwirtschaft ermöglichten. Der in Göttingen entwickelte Buschhäcksler ist ein Ansatz zur Mechanisierung der feuerfreien Flächenvorbereitung. Erste Tests sind im Herbst 1997 durchgeführt worden.
Conformational and stereochemical analysis as starting point for the design of antiviral compounds (1999)

status: Published
The closure of the space of spectral curves of constant mean curvature tori in $\mathbb{R}^3$ with spectral genus 2 (2021)

Where $\mathcal{H}^2$ is the space of spectral curves of real solutions of the sinh-Gordon equation of spectral genus $2$, and $\mathcal{S}^2$ is the closure in $\mathcal{H}^2$ of the space of spectral curves of constant mean curvature tori in $\mathbb{R}^3$ of spectral genus $2$, we study the boundary of $\mathcal{S}^2$ at first in the space of polynomials of degree $\leq 4$, and then also the boundary where coefficients of the spectral polynomial go to $\infty$. We also prove that the Wente family, i.e. the family of members of $\mathcal{S}^2_1$ described by polynomials with real coefficients, is 1-dimensional, smooth and connected.