gebhart/patrepeval huggingface dataset:
Interferon-gamma overcomes the glucocorticoid-mediated and the interleukin-4-mediated inhibition of interleukin-1 beta synthesis in human monocytes. (1993)

Interleukin-1 (IL-1) has been implicated in the tissue destruction of rheumatoid arthritis, a disease that is widely treated with glucocorticoids. In this study we investigated the effect of the T cell product interferon-gamma (IFN-gamma) on the glucocorticoid-mediated and on the IL-4-mediated inhibition of IL-1 beta mRNA and IL-1 beta protein synthesis in highly purified human monocytes. Both dexamethasone and IL-4 dose-dependently inhibited IL-1 beta mRNA and IL-1 beta protein synthesis after stimulation with LPS (300 ng/ml); maximal inhibition of 80-90% was achieved. IFN-gamma (1-100 U/ml) did not influence IL-1 beta mRNA and IL-1 beta protein levels in unstimulated cells, but potentiated the LPS-induced synthesis of IL-1 beta mRNA and IL-1 beta protein. After a preincubation time of 1 h, 100 U/ml of IFN-gamma increased the LPS-induced IL-1 beta production by about 20-40%. When human monocytes were preincubated for 1 h with IFN-gamma (100 U/ml) prior to the addition of dexamethasone (10(-6) M) and prior to the stimulation with LPS, the dexamethasone-mediated inhibition of IL-1 beta mRNA and IL-1 beta protein synthesis was totally neutralized by IFN-gamma. In addition, IFN-gamma totally overcame the negative effect of IL-4 (100 pM) on IL-1 beta protein synthesis. A preincubation period of at least 1 h with IFN-gamma was necessary for the neutralization of the dexamethasone effect. If IFN-gamma was given at the same time or after dexamethasone, only a weak effect was found.(ABSTRACT TRUNCATED AT 250 WORDS)
Strongly Emitting Fluorophores Based on 1-Azaperylene Scaffold (2010)

A novel blue-emitting polycyclic aromatic system was synthesized via anion-radical coupling. Its efficient direct hydroxylation led to a phenol possessing an intramolecular hydrogen-bond system. Since the energy gap difference between the enol and keto forms of this molecule is very small, characteristic of ESIPT chromophores, bathochromically shifted fluorescence was not observed.
HTS flux concentrator for non-invasive sensing of charged particle beams (2001)

The principle of the superconducting cryogenic current comparator (CCC) is applied to the non-invasive sensing of charged-particle beams (ions, electrons). With the use of HTS components it is feasible to envisage applications, for example, in precision mass spectrometry and real-time monitoring of ion-beam implantation currents. Recent simulations and experimental measurements of the flux concentration ratio, frequency response and linearity of a prototype HTS-CCC operating at 77 K are described.
Introduction to Algorithms: A Creative Approach (1989)

Introduction. Mathematical Induction. Analysis of Algorithms. Data Structures. Design of Algorithms by Induction. Algorithms Involving Sequences and Sets. Graph Algorithms. Geometric Algorithms. Algebraic and Numeric Algorithms. Reductions. NP-Completeness. Parallel Algorithms.
Reflections on Seminole Rock: The Past, Present, and Future of Deference to Agency Regulatory Interpretations (2016)

Seminole Rock (or Auer) deference has captured the attention of scholars, policymakers, and the judiciary. That is why Notice &amp; Comment, the blog of the Yale Journal on Regulation and the American Bar Association’s Section of Administrative Law &amp; Regulatory Practice, hosted an online symposium from September 12 to September 23, 2016 on the subject. This symposium contains over 20 contributions addressing different aspects of Seminole Rock deference.\nTopics include:\nHistory of Seminole Rock\nEmpirical Examinations of Seminole Rock\nUnderstanding Seminole Rock Within Agencies\nUnderstanding Seminole Rock as Applied to Tax, Environmental Law, and Criminal Sentencing\nWhy Seminole Rock Matters\nShould the Supreme Court Overrule Seminole Rock?\nWould Overruling Seminole Rock Have Unintended Consequences?\nWhat Might the Supreme Court Do?\nWhat Might Congress Do?\nThe Future of Seminole Rock?
Optical-Drop Wavelength Assignment Problem for Wavelength Reuse in WDM Ring Metropolitan Area Networks (2005)

This paper presents a formulation of the optical-drop wavelength assignment problem (ODWAP) and its heuristic algorithm for WDM ring networks. The wavelength-division multiplexing (WDM) technology has been popular in communication societies for providing very large communication bands by multiple lightpaths with different wavelengths on a single optical fiber. Particularly, a double-ring optical network architecture based on the packet-over-WDM technology such as the HORNET architecture has been studied as a next generation platform for metropolitan area networks (MANs). Each node in this architecture is equipped with a wavelength-fixed optical-drop and a tunable transmitter so that a lightpath can be established between any pair of nodes without wavelength conversions. In this paper, we formulate ODWAP for efficient wavelength reuse under heterogeneous traffic in this network. Then, we propose a simple heuristic algorithm for ODWAP. Through extensive simulations, we demonstrate the effectiveness of our approach in reducing waiting times for packet transmissions when a small number of wavelengths are available to retain the network cost for MANs.
Modeling Learning in Route Choice (2007)

Performing the same trip many times, travelers can learn about available routes from their experiences. Two types of learning found in psychological learning theory appear to play a role in day-to-day route choice: implicit (reinforcement-based) and explicit (belief-based). Memory decay also plays a major role. Although much progress had been made in modeling learning in route choice, a model that captures both learning types and for which the parameters are empirically underpinned was not found. Such a model thus is developed, and a large data set from experimental research is used to validate it and to estimate its parameters. The developed model uses a Markov formulation for the day-to-day updating of a person's belief about travel time (i.e., perceived travel time) on a route. Reinforcement (and inertia) is modeled by including the latest 10 route choices in the model. Results indicate that 20% of perceived travel time is from the most recent experience; therefore, formulations that use either the mathematical mean of all past experienced travel times or only the most recent travel times are not accurate. Furthermore, the reinforcement–inertia part of the model can make up a significant part of the route utility and therefore should be a standard component in route choice models. In sum, the results validate the theoretical and mathematical model.
Self pressuring HTP feed systems (1999)

Hydrogen peroxide tanks can be pressurized with decomposed HTP (high test hydrogen peroxide) originating in the tank itself. In rocketry, this offers the advantage of eliminating bulky and heavy inert gas storage. Several prototype self-pressurizing HTP systems have recently been designed and tested. Both a differential piston tank and a small gas-driven pump have been tried to obtain the pressure boost needed for flow through a gas generator and back to the tank. Results include terrestrial maneuvering tests of a prototype microsatellite, including warm gas attitude control jets.
Influence of various antibacterial preparations on rate and efficiency of gain by young pigs (1973)

Two trials involving 128 pigs were conducted to study the effects of antibacterial preparations on rate and efficiency of gain by young pigs. In both trials, the antibacterial preparations increased rate of gain. In trial I, there were no differences in performance of pigs fed ASP-250, Mecadox, or TNA-290. In the second trial, pigs fed Mecadox gained faster than pigs fed ASP-250, Furox or Neo-Terramycin. Pigs fed diets supplemented with the various antibacterial preparations utilized feed more efficiently than those fed the nonmedicated basal diet.; Swine Day, Manhattan, KS, November, 1973
Antisense oligonucleotides in the treatment of bladder cancer (2005)

This review examines the role that antisense oligonucleotides play in the treatment of superficial and muscle-invasive bladder cancer. The unique environment of the urinary bladder allows intravesical instillation of antisense oligonucleotides, and researchers have already demonstrated uptake of antisense oligonucleotides in models of bladder cancer. Second, proof of principle has been established by demonstrating downregulation of the antisense target mRNA and protein. Third, and most importantly from a therapeutic perspective, synergy between chemotherapy and antisense oligonucleotides has been shown in bladder cancer models in vitro and in vivo. The collective evidence points to a role for antisense oligonucleotides in the treatment of superficial and muscle-invasive bladder cancer in combination with existing treatment modalities.
A Rate‐Independent Method of Assessing QT‐RR Slope Following Conversion of Atrial Fibrillation (2007)

The results of this study demonstrate that QT interval can be reliably measured in AF using a method that is independent of heart rate. We also showed that cardioversion of AF acutely increases the QT interval and the steepness of the QT-RR slope.
CMOS integration of dual work function phase controlled Ni FUSI with simultaneous silicidation of NMOS (NiSi) and PMOS (Ni-rich silicide) gates on HfSiON (2006)

We demonstrate for the first time CMOS integration of dual WF (work function) metal gates on HfSiON using Ni-phase controlled FUSI. The novel integration scheme that we demonstrate uses our optimized 2-step Ni FUSI process (1) for simultaneous full silicidation of nMOS and pMOS, achieving different Ni/Si ratios on nMOS and pMOS by reduction of the pMOS poly height through a selective and controlled poly etch back prior to gate silicidation. This novel integration scheme offers the advantages of 1) simplicity (same Ni deposition and silicidation process on nMOS and pMOS), 2) large process window for poly etch-back process (same pMOS characteristics for poly thickness variation of 50%), 3) WF and Vt tuning on HfSiON by phase control, with 4) scalable, linewidth independent suitable Vt's for nMOS (0.5 V) and pMOS (-0.3 V), and 5) solves process yield issues of Ni-rich silicides related to volume expansion, stress, filaments and voiding, resulting in a continuous silicide that is nicely confined between the sidewall spacers. Ring oscillator operation was also demonstrated
Test Of Protective Coatings On Carbon Steel (1993)

Report describes results of tests in which carbon-steel panels coated with one-or two-component solvent-based inorganic zinc primers and top-coated with inorganic topcoat or any of various organic topcoats, placed on outdoor racks at beach at Kennedy Space Center for 5 years. From time to time, slurry of Al(2)O(3) in 10-percent HCI solution applied to some of panels to simulate corrosive effect of effluent from solid-fuel rocket booster engines. Panels coated with inorganic topcoat performed much better than organic-topcoated panels.
Integrated ScAlN Photonic Circuits on Silicon Substrate (2020)

ScAlN has been applied in piezoelectric micro-electro-mechanical systems, while application in photonics remains unexplored. Here, ScAlN photonic circuits on silicon are presented, demonstrating waveguide propagation loss of 9±2 dB/cm and microring quality factor of 1.4×10 4 .
Silicon Ardor (1991)

Review| November 01 1991 Silicon Ardor Technoculture, edited by Constance Penley and Andrew Ross, University of Minnesota Press/ 327 pp/ (sb) $15.95 Jon Lewis Jon Lewis Jon Lewis is an associate professor in the English Department at Oregon State University Search for other works by this author on: This Site PubMed Google Scholar Afterimage (1991) 19 (4): 13–14. https://doi.org/10.1525/aft.1991.19.4.13 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Jon Lewis; Silicon Ardor. Afterimage 1 November 1991; 19 (4): 13–14. doi: https://doi.org/10.1525/aft.1991.19.4.13 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAfterimage Search This content is only available via PDF. © 1991 by The Regents of the University of California1991 Article PDF first page preview Close Modal You do not currently have access to this content.
ChemInform Abstract: SYNTHESIS OF 25‐FLUOROVITAMIN D3 (1977)

Abstract Aus dem Diol (Ia) erhält man das Monoacetat (Ib), das mit Diäthylaminoschwefeltrifluorid zu (Ic) fluoriert wird.
Biomimetically synthesized luminescent Tb3+-doped fluorapatite/agar nanocomposite for detecting UO22+, Cu2+, and Cr3+ions (2021)

Biodegradable rare earth doped fluorapatite has been developed as a luminescence probe for the detection of both radioactive and nonradioactive ions.
Transcriptomic profiles of aging in purified human immune cells (2015)

An overall decline in expression of ribosomal protein synthesis genes with age was detected in CD14+ monocytes and CD4+ T cells, demonstrating that some patterns of aging are likely shared between different cell types. Our findings also support cell-specific effects of age on gene expression, illustrating the importance of using purified cell samples for future transcriptomic studies. Longitudinal work is required to establish the relationship between identified age-associated genes/pathways and aging-related diseases.
Dynamic MRI of Invasive Breast Cancer: Assessment of Three Region-of-Interest Analysis Methods (1997)

Variability is inherent in subjective ROI analysis, but the semiautomated method of ROI selection and sampling of parameter images of the breast is an efficient and reliable alternative that may allow better standardization of the MR technique.
Amplification of c-erbB-2 and Aggressive Human Breast Tumors? (1988)

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ChemInform Abstract: Influence of Quaternization or Coordination of Nitrogen with a Lewis Acid upon the Diastereoselectivity of 5‐exo Ring Closure of β‐Aminoalkyl Radicals. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interferon inducible pseudouridine modification in human mRNA by quantitative nanopore profiling (2021)

Pseudouridine (Ψ) is an abundant mRNA modification in mammalian transcriptome, but its functions have remained elusive due to the difficulty of transcriptome-wide mapping. We develop a nanopore native RNA sequencing method for quantitative Ψ prediction (NanoPsu) that utilizes native content training, machine learning modeling, and single-read linkage analysis. Biologically, we find interferon inducible Ψ modifications in interferon-stimulated gene transcripts which are consistent with a role of Ψ in enabling efficacy of mRNA vaccines.
Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold (2021)

The current pandemic caused by SARS-CoV2 and named COVID-19 urgent the need for novel lead antiviral drugs. Recently, United States Food and Drug Administration (FDA) approved the use of remdesivir as anti-SARS-CoV-2. Remdesivir is a natural product-inspired nucleoside analogue with significant broad-spectrum antiviral activity. Nucleosides analogues from marine sponge including spongouridine and spongothymidine have been used as lead for the evolutionary synthesis of various antiviral drugs such as vidarabine and cytarabine. Furthermore, the marine sponge is a rich source of compounds with unique activities. Marine sponge produces classes of compounds that can inhibit the viral cysteine protease (M<sup>pro</sup>) such as esculetin and ilimaquinone and human serine protease (TMPRSS2) such as pseudotheonamide C and D and aeruginosin 98B. Additionally, sponge-derived compounds such as dihydrogracilin A and avarol showed immunomodulatory activity that can target the cytokines storm. Here, we reviewed the potential use of sponge-derived compounds as promising therapeutics against SARS-CoV-2. Despite the reported antiviral activity of isolated marine metabolites, structural modifications showed the importance in targeting and efficacy. On that basis, we are proposing a novel structure with bifunctional scaffolds and dual pharmacophores that can be superiorly employed in SARS-CoV-2 infection.
First Results of GINGERino, a deep underground ringlaser (2016)

Large ring-laser gyroscopes are capable of measuring angular rotations with a precision well below fractions of $prad/s$, not far from $10^{-14}$ $rad/s$, the accuracy required for General Relativity tests, this is what the GINGER (Gyroscope-IN-GEneral-Relativity) experiment is aiming for. These features do not guarantee the possibility of measuring the General Relativity Lense--Thirring effect, that manifests itself as a tiny ($\approx 10^{-9} \times Ω_E$) perturbation of the Earth rotation rate. An underground location being in principle less affected by external local disturbances represents a good candidate for housing such a challenging experiment. GINGERino is a test apparatus to investigate the residual local disturbances in the most inner part of the underground international laboratory of the GranSasso (LNGS). It consists of a square ring laser with a $3.6$ m side. The instrument has been tailored to be the larger allowed by the particular location inside the laboratory. Its main objective is to measure the very low frequency rotational motions, in order to prove that LNGS is a suitable location for very low noise measurements and, possibly, General Relativity tests. Aside this main goal, GINGERino will provide unique data for geodesy and geophysics. Its installation has been completed during 2015. Since then, several long set of data have been collected, and the apparatus has been continuously running unattended for more than one week. The typical power spectrum sensitivity was a few $ 10^{-10} rad/s/\sqrt(Hz)$, with integration time not longer than tens of seconds. Improvements of the apparatus are ongoing in order to improve the integration time.
Nodal Disease in Rectal Cancer Patients With Complete Tumor Response After Neoadjuvant Chemoradiation: Danger Below Calm Waters (2017)

Ten percent of patients with ypT0 tumors had positive nodes after chemoradiation therapy and resection. Factors associated with residual nodal disease included clinical nodal disease at diagnosis and poor histologic features. Patients with any of these features should consider radical resection regardless of tumor response. Others could be suitable for "watchful waiting" strategies. See Video Abstract at http://links.lww.com/DCR/A458.
Network metrics for assessing the quality of entity resolution between multiple datasets1 (2020)

Matching entities between datasets is a crucial step for combining multiple datasets on the semantic web. A rich literature exists on different approaches to this entity resolution problem. However, much less work has been done on how to assess the quality of such entity links once they have been generated. Evaluation methods for link quality are typically limited to either comparison with a ground truth dataset (which is often not available), manual work (which is cumbersome and prone to error), or crowd sourcing (which is not always feasible, especially if expert knowledge is required). Furthermore, the problem of link evaluation is greatly exacerbated for links between more than two datasets, because the number of possible links grows rapidly with the number of datasets. In this paper, we propose a method to estimate the quality of entity links between multiple datasets. We exploit the fact that the links between entities from multiple datasets form a network, and we show how simple metrics on this network can reliably predict their quality. We verify our results in a large experimental study using six datasets from the domain of science, technology and innovation studies, for which we created a gold standard. This gold standard, available online, is an additional contribution of this paper. In addition, we evaluate our metric on a recently published gold standard to confirm our findings.
SoK: The Challenges, Pitfalls, and Perils of Using Hardware Performance Counters for Security (2019)

Hardware Performance Counters (HPCs) have been available in processors for more than a decade. These counters can be used to monitor and measure events that occur at the CPU level. Modern processors provide hundreds of hardware events that can be monitored, and with each new processor architecture more are added. Yet, there has been little in the way of systematic studies on how performance counters can best be utilized to accurately monitor events in real-world settings. Especially when it comes to the use of HPCs for security applications, measurement imprecisions or incorrect assumptions regarding the measured values can undermine the offered protection. To shed light on this issue, we embarked on a year-long effort to (i) study the best practices for obtaining accurate measurement of events using performance counters, (ii) understand the challenges and pitfalls of using HPCs in various settings, and (iii) explore ways to obtain consistent and accurate measurements across different settings and architectures. Additionally, we then empirically evaluated the way HPCs have been used throughout a wide variety of papers. Not wanting to stop there, we explored whether these widely used techniques are in fact obtaining performance counter data correctly. As part of that assessment, we (iv) extended the seminal work of Weaver and McKee from almost 10 years ago on non-determinism in HPCs, and applied our findings to 56 papers across various application domains. In that follow-up study, we found the acceptance of HPCs in security applications is in stark contrast to other application areas - especially in the last five years. Given that, we studied an additional representative set of 41 works from the security literature that rely on HPCs, to better elucidate how the intricacies we discovered can impact the soundness and correctness of their approaches and conclusions. Toward that goal, we (i) empirically evaluated how failure to accommodate for various subtleties in the use of HPCs can undermine the effectiveness of security applications, specifically in the case of exploit prevention and malware detection. Lastly, we showed how (ii) an adversary can manipulate HPCs to bypass certain security defenses.