gebhart/patrepeval huggingface dataset:
Correction to “Film Conformality and Extracted Recombination Probabilities of O Atoms during Plasma-Assisted Atomic Layer Deposition of SiO2, TiO2, Al2O3 and HfO2” (2019)

RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to “Film Conformality and Extracted Recombination Probabilities of O Atoms during Plasma-Assisted Atomic Layer Deposition of SiO2, TiO2, Al2O3 and HfO2”Karsten ArtsKarsten ArtsMore by Karsten Artshttp://orcid.org/0000-0003-4266-6559, Mikko UtriainenMikko UtriainenMore by Mikko Utriainen, Riikka L. PuurunenRiikka L. PuurunenMore by Riikka L. Puurunen, Wilhelmus M. M. Kessels*Wilhelmus M. M. KesselsMore by Wilhelmus M. M. Kesselshttp://orcid.org/0000-0002-7630-8226, and Harm C. M. Knoops*Harm C. M. KnoopsMore by Harm C. M. Knoopshttp://orcid.org/0000-0003-2284-4477Cite this: J. Phys. Chem. C 2020, 124, 1, 1250Publication Date (Web):December 19, 2019Publication History Published online19 December 2019Published inissue 9 January 2020https://doi.org/10.1021/acs.jpcc.9b11082Copyright © 2019 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoicewith CC-BY-NC-NDlicenseArticle Views372Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (287 KB) Get e-Alerts Get e-Alerts
Modal Expansion Analysis, Inverse Design, and Experimental Verification of a Broadband High-Aperture Efficiency Circular Short Backfire Antenna Loaded With Anisotropic Impedance Surfaces (2023)

In this article, a broadband highly efficient circular short backfire antenna (SBFA) loaded with cylindrical anisotropic impedance surfaces (AISs) is proposed. An efficient modal expansion method (MEM) is developed to facilitate the analysis of the AIS-loaded SBFA with a finite-sized flange, which considerably reduces the computational resources as compared to commercial full-wave solvers. By combining the MEM with a multiobjective genetic algorithm, the geometrical dimensions of the antenna and the dispersive properties of the AIS are optimized through an inverse design strategy. As a proof-of-concept example, an S-band AIS-loaded SBFA with a broad bandwidth and high aperture efficiency is demonstrated, showing a good agreement between measured results and simulation predictions. An aperture efficiency of greater than 83% is experimentally achieved over a broad <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$S_{11} &lt; -10$ </tex-math></inline-formula> dB bandwidth of 35.3%, with a peak aperture efficiency of about 100%. Moreover, the underlying operating principle of the antenna is revealed by the investigation of the main propagating modes in the SBFA. The extraordinary performance demonstrates that the proposed AIS-loaded SBFA represents a promising candidate for various wireless communication systems.
Ubiquitous and Tissue-specific RNA Targeting in <em>Drosophila Melanogaster</em> using CRISPR/CasRx (2021)

CasRx, a member of the RNA-targeting Cas13 family, is a promising new addition of the CRISPR/Cas technologies in efficient gene transcript reduction with an attractive off-target profile at both cellular and organismal levels. It is recently reported that the CRISPR/CasRx system can be used to achieve ubiquitous and tissue-specific gene transcript reduction in Drosophila melanogaster. This paper details the methods from the recent work, consisting of three parts: 1) ubiquitous in vivo endogenous RNA targeting using a two-component CasRx system; 2) ubiquitous in vivo exogenous RNA targeting using a three-component CasRx system; and 3) tissue-specific in vivo RNA targeting using a three-component CasRx system. The effects of RNA targeting observed include targeted gene specific phenotypic changes, targeted RNA transcript reduction, and occasional lethality phenotypes associated with high expression of CasRx protein and collateral activity. Overall, these results showed that the CasRx system is capable of target RNA transcript reduction at the organismal level in a programmable and efficient manner, demonstrating that in vivo transcriptome targeting, and engineering is feasible and lays the foundation for future in vivo CRISPR-based RNA targeting technologies.
Hybrid EEG/EOG-based brain/neural hand exoskeleton restores fully independent daily living activities after quadriplegia (2016)

Direct brain control of advanced robotic systems promises substantial improvements in health care, for example, to restore intuitive control of hand movements required for activities of daily living in quadriplegics, like holding a cup and drinking, eating with cutlery, or manipulating different objects. However, such integrated, brain- or neural-controlled robotic systems have yet to enter broader clinical use or daily life environments. We demonstrate full restoration of independent daily living activities, such as eating and drinking, in an everyday life scenario across six paraplegic individuals (five males, 30 ± 14 years) who used a noninvasive, hybrid brain/neural hand exoskeleton (B/NHE) to open and close their paralyzed hand. The results broadly suggest that brain/neural-assistive technology can restore autonomy and independence in quadriplegic individuals' everyday life.
RELATIONSHIP OF SOLUBLE SOLIDS, ACIDITY AND AROMA VOLATILES TO FLAVOR IN LATE-SEASON NAVEL ORANGES (2010)

Late-season navel oranges in California sometimes have poor flavor even though they have high soluble solids content (SSC) and are very sweet. The reasons for this low flavor quality were investigated by evaluating individual late-season navel oranges for sensory attributes and then measuring SSC, titratable acidity (TA) and aroma volatiles from juice taken from the same oranges. A wide range in hedonic scores from below a rating of 4 (dislike slightly) to above 8 (like very much) was obtained for the 95 fruit evaluated, although 78% of the fruit were above a rating of 6 (like slightly). Correlation coefficients calculated between the sensory and chemical (SSC, TA and flavor volatiles) attributes were mostly non-significant and, in every case, very low, indicating that there were no clearly identifiable reasons for the flavor differences observed among the individual fruit. Partial least squares analysis using the combined chemical data as a dependent variable came to a similar conclusion and was able to account for only 25% of the variation in the sensory data by using the chemical data. It is possible that components other than those that were evaluated were responsible for the flavor differences or that the fruit were too similar in taste for our sensory panel to accurately categorize on an individual fruit basis.
Developing one-dimensional implosions for inertial confinement fusion science (2016)

Experiments on the National Ignition Facility show that multi-dimensional effects currently dominate the implosion performance. Low mode implosion symmetry and hydrodynamic instabilities seeded by capsule mounting features appear to be two key limiting factors for implosion performance. One reason these factors have a large impact on the performance of inertial confinement fusion implosions is the high convergence required to achieve high fusion gains. To tackle these problems, a predictable implosion platform is needed meaning experiments must trade-off high gain for performance. LANL has adopted three main approaches to develop a one-dimensional (1D) implosion platform where 1D means measured yield over the 1D clean calculation. A high adiabat, low convergence platform is being developed using beryllium capsules enabling larger case-to-capsule ratios to improve symmetry. The second approach is liquid fuel layers using wetted foam targets. With liquid fuel layers, the implosion convergence can be controlled via the initial vapor pressure set by the target fielding temperature. The last method is double shell targets. For double shells, the smaller inner shell houses the DT fuel and the convergence of this cavity is relatively small compared to hot spot ignition. However, double shell targets have a different set of trade-off versus advantages. Details for each of these approaches are described.
Optimizing Aesthetics with Prosthetic Prepectoral Breast Reconstruction (2017)

Sir: I read the article “Prepectoral Breast Augmentation: A Safe Alternative to Submuscular Prosthetic Reconstruction following Nipple-Sparing Mastectomy” by Sbitany et al.1 with interest. However, I feel that they failed to adequately emphasize an important reason for inserting the prosthesis in the prepectoral position: aesthetic. The breast is a subcutaneous structure—there is no breast tissue under the pectoralis muscle. The best and most natural results in breast augmentation occur when the prosthesis is placed in a subglandular position.2 Similarly, one of the “advantages” of immediate autologous reconstruction is that it is placed in a prepectoral/subglandular position, which enhances the aesthetic result. The submuscular position was (historically) selected for three reasons2: (1) because of the belief that there was a lower incidence of capsular contracture (however, there is little long-term evidence to support this); (2) to disguise rippling of the prosthesis; and (3) to reduce the visibility of the superior edge of the prosthesis in the upper pole of the breast, especially in very thin women. The authors correctly highlight shape distortion in the submuscular plane that occurs secondary to pectoralis muscle contraction.1 The dual plane offers an attempt to gain some of the advantages of the prepectoral position, but some shape distortion may still occur from muscle action. The prosthesis is subcutaneous in the lower pole of the breast anyway. There have been major advances in prosthetic manufacture; thus, rippling is now an uncommon problem. Also, the recent generation of prostheses have different profiles and retain their shape, unlike the older, low-profile prostheses, which were more amorphous. Also, where rippling occurred, the edge of the prosthesis was sometimes visible in the upper pole of the breast. In addition, capsular contracture may be related rather to biofilm formation,3 not position of the prosthesis. It has been postulated that the shape of the breast envelope is retained after skin-sparing mastectomy.4 The whole breast envelope is retained in a nipple-sparing mastectomy, adding another reason to opt for the subcutaneous position in cancer reconstruction. It is also important for aesthetic reasons that the original inframammary fold is retained and remains intact. This article illustrates a growing trend moving from a submuscular to a subglandular/prepectoral position in prosthetic breast reconstruction and thereby achieving a better cosmetic result. The reasons for prosthetic submuscular placement are no longer widely applicable. I congratulate the authors on their innovation. DISCLOSURE The author has no financial interest to declare in relation to the content of this communication. There is no funding to declare. Don A. Hudson, F.R.C.S., F.C.S.(S.A.), M.Med.Department of Plastic and Reconstructive SurgeryH53 OMBGroote Schuur HospitalObservatory, 7925Cape Town, South Africa[email protected]
Surface Nanopatterned Shape Memory Alloy (SMA)‐Based Photosensitive Artificial Muscle (2021)

Abstract Light‐driven shape memory alloy (SMA)‐based microscale actuators show great promise for artificial muscle and biomedical applications, as they are actuated remotely and have a fast response speed. However, ultraviolet (UV) light is required for device actuation; thus, the operating environment has been limited. Here, an infrared (IR) light‐driven SMA actuator is proposed, in which the plasmonic effect is used to enhance IR light absorptance. A sub‐micrometer pattern is used to create an optical meta‐surface capable of tuning the light absorptance. Conical nanohole arrays are fabricated with a focused ion beam. The absorptance tuning effect is evaluated in terms of the optical characteristics and performance of the actuator. The nanopatterned surface increases the narrow‐band IR light absorption by up to 55%. Optics simulations are conducted to verify the experimental results. A pattern design method is proposed, based on the light wavelength of the stimulating source. Combining heterogeneous surfaces, both UV and IR light achieve decoupled microscale actuation. These actuators show a response similar to that of the iris muscle, which is responsible for the eye's pupillary reflex. It is expected that these actuators will broaden SMA applications in clinical devices and soft robotics.
Synergistic inhibition of human cell-mediated cytotoxicity by complement component antisera indicates that target cell lysis may result from an enzymatic cascade involving granzymes and perforin. (1995)

A widely accepted theory of lymphocyte-mediated cytotoxicity (CMC) proposes that upon effector cell (EC) and target cell (TC) interaction, release of perforin, serine proteases and other lytic moieties contained within cytoplasmic granules results in TC lysis. Complement activation and the activation of the various enzymatic activities associated with cytotoxic granules have strikingly similar modes of action and both lead to pore formation in their respective targets. We report here that by using antisera to early and late complement components we were able to inhibit CTL, NK and ADCC cytotoxicity up to 100%, even though binding of EC to TC was unaffected. Furthermore, we showed that addition of C1q or C1s (two serine proteases) antisera to C9 antisera, at titers too low to inhibit separately, resulted in synergistic inhibition of CMC. Anti-C1s together with anti-C1q (or anti-C8 with anti-C9) did not result in synergy. This finding supports a cascade model of activation for lytic molecules released from EC. In addition, we demonstrated that anti-C1q and anti-C1s bind to proteins in the 30-kD region and anti-C9 binds to proteins in the 70-kD region, coinciding with published molecular weights of granzymes and perforin, respectively. Finally, lytic ability of purified granules was also inhibited by complement antisera, further suggesting that activation occurs outside of TC. Taken as a whole, these data indicate that TC lysis may be the result of a cascade of events involving granzymes and perforin, analogous to that seen with the complement system.
The Substrate Import Mechanism of the Human Serotonin Transporter (2019)

The serotonin transporter, SERT, initiates the reuptake of extracellular serotonin in the synapse to terminate neurotransmission. Recently, the cryo-EM structures of SERT bound to ibogaine resolved in different states provided the first glimpse of functional conformations at atomistic resolution. However, the conformational dynamics and structural transitions to various intermediate states are not fully understood. Furthermore, while experimental SERT structures were complexed with drug molecules and inhibitors, the molecular basis of how the physiological substrate, serotonin, is recognized, bound, and transported remains unclear. In this study, we performed microsecond long simulations of the human SERT to investigate the structural dynamics to various intermediate states and elucidated the complete substrate import pathway. Using Markov state models, we characterized a sequential order of conformational driven ion-coupled substrate binding and transport events and calculated the free energy barriers of conformation transitions associated with the import mechanism. We identified a set of crucial residues that recognize the substrate at the extracellular surface of SERT and our biochemical screening results show that mutations causes dramatic reduction in transport function. Our simulations also revealed a third sodium ion binding site coordinated by Glu136 and Glu508 in a buried cavity which helps maintain the conserved fold adjacent to the orthosteric site for transport function. The mutation of these residues results in a complete loss of transport activity. Our study provides novel insights on the molecular basis of dynamics driven ion-substrate recognition and transport of SERT that can serve as a model for other closely related neurotransmitter transporters.
Unrestricted Hartree–Fock method for infinite systems with antiferromagnetic array: Analysis of antiferromagnetic state of trans‐polyacetylene (1993)

Abstract An improved unrestricted Hartree–Fock (UHF) crystal orbital method for infinite one‐dimensional systems having antiferromagnetic spin array is presented. This variational version of the UHF method is composed of two steps of self‐consistent‐field (SCF) calculations. The second SCF equation is to be solved using the canonical transformation between specific crystal orbitals around the Fermi level of the first conventional SCF solution. The energy gain and the forbidden band gap (correlation gap) associated with the hypothetical antiferromagnetic state of trans ‐polyacetylene are examined as an example. © 1993 John Wiley &amp; Sons, Inc.
High-speed integrated DFB/electroabsorption modulated lasers (1996)

Summary form only given. This talk describes results of integrated devices incorporating DFB laser and electroabsorption modulator sections. Results for packaged devices will be shown, including data from long term (<10/sup -15/ BER) transmission experiments.
Design of Membrane Active Peptides Considering Multi-Objective Optimization for Biomedical Application (2022)

A multitude of membrane active peptides exists that divides into subclasses, such as cell penetrating peptides (CPPs) capable to enter eukaryotic cells or antimicrobial peptides (AMPs) able to interact with prokaryotic cell envelops. Peptide membrane interactions arise from unique sequence motifs of the peptides that account for particular physicochemical properties. Membrane active peptides are mainly cationic, often primary or secondary amphipathic, and they interact with membranes depending on the composition of the bilayer lipids. Sequences of these peptides consist of short 5-30 amino acid sections derived from natural proteins or synthetic sources. Membrane active peptides can be designed using computational methods or can be identified in screenings of combinatorial libraries. This review focuses on strategies that were successfully applied to the design and optimization of membrane active peptides with respect to the fact that diverse features of successful peptide candidates are prerequisites for biomedical application. Not only membrane activity but also degradation stability in biological environments, propensity to induce resistances, and advantageous toxicological properties are crucial parameters that have to be considered in attempts to design useful membrane active peptides. Reliable assay systems to access the different biological characteristics of numerous membrane active peptides are essential tools for multi-objective peptide optimization.
Optimal design of the coils of an electromagnetic flow meter (1998)

A new method of optimal design of the excitation coil for an electromagnetic flow meter is presented, The main goal is to form an algorithm which will be able to deal with natural channels of any shape with conductive beds/banks. The presented method allows an engineer to design an optimal coil to obtain homogeneity of the special weight vector W. This homogeneity provides that the voltage measured between the electrodes of the flow meter will be proportional to the mean velocity of the liquid in the channel. The optimization of the coil shape is carried out through minimization of an objective function defined on the basis of a finite element method 2D model of the cross-section of the channel.
Supplementary Figure 6 from A Novel Human Dynactin-Associated Protein, dynAP, Promotes Activation of Akt, and Ergosterol-Related Compounds Induce dynAP-Dependent Apoptosis of Human Cancer Cells (2023)

Supplementary Figure 6 from A Novel Human Dynactin-Associated Protein, dynAP, Promotes Activation of Akt, and Ergosterol-Related Compounds Induce dynAP-Dependent Apoptosis of Human Cancer Cells
A compact and universal cellular neural network cell based on resonant tunneling diodes: circuit, model, and functional capabilities (2002)

A novel cellular neural network (CNN) cell and its circuit realization are proposed. The theory of the multi-nested universal cell is applied, and the nonmonotonic current-voltage characteristic of resonant tunneling diodes (RTD) is exploited to achieve a high functionality. The proposed cell has the potential of implementing arbitrary local Boolean functions with n inputs. The cell has a complexity of only O(n) in the number of devices and template elements. For comparison, the digital n-to-1 multiplexor, a functionally equivalent system has a complexity of O(2/sup n/). A simple, piecewise-linear mathematical model is derived and used to evaluate the functional capabilities of the RTD-CNN cell. The model was proved to be accurate enough, and only minor tuning of some of the parameters is necessary to achieve the same functionality using a Spice simulation of the same circuit, which is based on more refined physical device models.
X-Ray crystal structure and absolute configuration of p-bromophenacylseptamycin monohydrate, a polyether antibiotic (1974)

T. J. Petcher and H. Weber, J. Chem. Soc., Chem. Commun., 1974, 697 DOI: 10.1039/C39740000697
Self-dependent equivalent circuit modeling of electrostatic comb transducers for integrated MEMS (2011)

The paper presents a new equivalent circuit model of electrostatic comb transducers for large-scale integration of MEMS into LSI. The model detects the displacement using a dummy spring to express the current induced by the movement, and the model parameters can be derived from only its dimensions not from external parameters (acting force, applied voltage). In addition, the model is composed from basic circuit components. Therefore it is easily utilized in conventional circuit simulation software. In-plane two-degree-of-freedom comb model was applied to basic SOI resonator and the measured and simulated electrical and mechanical properties showed good agreement in each other. A simple oscillating circuit with constant amplitude control has been tested and the transient responses showed good agreement as well.
Vaccine Immunity to Diphtheria: A 20-Year Follow-up Study (1992)

A cohort of close to 70 children born in 1967-68 was followed for estimations of serum antitoxin levels against diphtheria. During the first 3-year-period after vaccination the mean level declined from 0.05 international units (IU) to 0.03. From the year before to the year after the booster of 0.5 LF of toxoid was given at the age of 8 years, the mean level raised from 0.01 to 0.06 IU. At 18 years the mean was again down to 0.01. Between 18 and 23 years of age a difference between the sexes was seen (higher levels in men). The explanation of this phenomenon must be the extra booster given to those young men who have done their compulsory military service.