gebhart/patrepeval huggingface dataset:
Figure S2 from Intestine-Specific Homeobox Gene <i>ISX</i> Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression (2023)

&lt;p&gt;Figure S2, AHR signals positively activated ISX expression in hepatoma cells. A, Relative mRNA expression levels of CYP1B1 and ISX in Hep 3B and SK-Hep1 cells with AHR overexpression as detected by semi-quantitative RT-PCR. Data are presented as means {plus minus} S.D. a, p &lt; 0.001. B, Relative mRNA expression levels of CYP1B1 and ISX in Huh 7 and SK-Hep1 cells with treated with AHR ligand, TCDD (5 nM) were detected by semi-quantitative RT-PCR. C, Western blotting analysis of ISX proteins in SK-Hep1 cells transfected with AHR, ARNT or AHR-ARNT complex D, AHR transcriptionally activated luciferase activity driven by promoters of ISX in SK-Hep1 cells. Relative luciferase activity was calculated as described in the Supplemental Materials and Methods. E, Western blotting analysis of ISX, IDOs, KYNU and downstream gene, CYP 1B1 proteins in Huh 7 and SK-Hep1 cells transfected with knockdown vector shRNAi against AHR. F, Schematic presentation of a series of luciferase deletions of ISX promoter. Relative luciferase activity in SK-Hep1 was calculated as described in the Materials and methods section. G, Chromatin was prepared and immunoprecipitated with anti-AHR antibody from SK-Hep1 and Huh7 cells treated with TCDD. H, The promoter regions of ISX with AHR-binding element (XRE) deletion were not pulled down by the anti-AHR antibody. I, Western blotting analysis of ISX, IDO1, IDO2, CYP1B1 and TDO2 expression in hepatocytes of AHR+/+, AHR+/â^'and AHR-/â^' mice.&lt;/p&gt;
The Impact of Detubularization on Ileal Reservoirs (1987)

For many years, parts of the large or small bowel have been used for bladder augmentation and substitution. Recent controversy over the advantages and disadvantages of continent urinary diversion using detubularized ileum (the Kock pouch) and tubular ileum (the Camey procedure) focussed on how a highly compliant urinary reservoir should be formed. We compared the compliance of isolated intact ileal segments and ileal pouches constructed after transection of the antimesenteric border. Hydrodynamic data was obtained at four different points in time: acute (immediately after pouch construction), and after two, six and twelve weeks. Over the first six weeks the reservoirs were connected to the bladder for drainage. At six weeks, subtotal cystectomy and separate anastomosis of the tubular ileal loop and the detubularized ileal pouch to the trigone was performed to study the influence of cyclic reservoir distention. Statistical analysis of the pressure-volume curves revealed significantly better compliance of the detubularized ileal pouch as compared to the intact ileal segments. The area under the pressure curve values (AUC) were p less than 0.025, p less than 0.02, p less than 0.005 and p less than 0.02 for the acute experiment, after two weeks, after six weeks, and after 12 weeks respectively. Our findings suggest that transection of the circular intestinal wall is an important step in the creation of a good-compliant urinary reservoir.
Development of a high-accuracy PC-based wattmeter with commercial data acquisition boards (2011)

This paper presents the development of a high accuracy sampling wattmeter, which makes use of two commercial data acquisition boards (DAQs) connected to a common personal computer. Commercial software is also used for data processing and implementation of the virtual instrument. The set up of the PC-based wattmeter is described and a preliminary evaluation of its metrological performances is made by means of two series of experimental tests, which were carried out with an electric power standard and a high performance multifunction calibrator.
Modulation of microglia scanning functions by Aflibercept (2017)

Resident microglia can be regarded as the immunological watchdogs of the brain and the retina. They are active sensors of their neuronal microenvironment and rapidly respond to various insults with a morphological and functional transformation into reactive phagocytes. There is strong evidence from animal models and in situ analyses of human tissue that microglial reactivity is a common hallmark of various retinal degenerative and inflammatory diseases. These include rare hereditary retinopathies such as retinitis pigmentosa but also comprise more common multifactorial retinal diseases such as age-related macular degeneration, diabetic retinopathy, glaucoma, and uveitis as well as neurological disorders with ocular manifestation. There is now increasing evidence from studies in rodents that systemic vascular endothelial growth factor (VEGF) receptor blockade by specific neutralizing antibodies or intra-vitreal anti-VEGF therapy significantly decrease the number of reactive microglia and infiltrating macrophages in the inflamed retina and choroid. Since sub-clinical and chronic inflammation linked to microglial activation contribute to retinal pathogenesis in AMD, microglial modulation by anti-VEGF could have beneficial effects concomitant with its role in reducing choroidal neovascularization (CNV) and edema formation. However, it was not yet clear whether anti-VEGF treatment directly affects microglia physiology. To address this question and to simulate a close to human system, we performed a cell culture study using human immortalized microglial cells, human ARPE19 RPE cells, 661W photoreceptor-like cells and Aflibercept (Eylea) as model compound for anti-VEGF medication. Our experiments showed that Aflibercept did not directly influence pro-inflammatory gene expression in activated human SV40-immortalized microglia or indirectly in ARPE19 retinal pigment epithelial cells treated with microglia-conditioned media. Aflibercept did also not affect microglia proliferation or their effects on the actin cytoskeleton of ARPE19-cells and survival of 661W photoreceptor cells. However, Aflibercept was very effective in inducing microglia filopodia formation, their phagocytosis of photoreceptor debris and their stimulated migration. These effects can be regarded as housekeeping functions of microglia and Aflibercept may thus be potentially beneficial in increasing microglial scanning functions in the retinal tissue. Further studies using the laser-coagulation model of murine CNV could be envisioned to verify these effects of Aflibercept in vivo.
Nuevos retos para la estrategia de operaciones en el sector de automoción (2005)

El dinamismo del sector de automocion y la adjudicacion de contratos comerciales a largo plazo de nuevos modelos de automoviles fuerza a un proveedor de primer nivel (TIER 1) a tomar decisiones a corto plazo que afectan a su estrategia de operaciones y a sus inversiones industriales. La realizacion del analisis necesario para abordar esta nueva situacion tambien provoca una revision de alguna decision a largo plazo, pero sin modificar la estrategia global de la empresa. La Direccion General en Espana y Portugal se plantea una serie de retos que necesita resolver y sobre los que debe actuar: ?Como puedo incrementar el valor aportado por mi empresa a los constructores de automoviles (OEMs)? ?Donde debo ubicar geograficamente las nuevas inversiones industriales necesarias? ?Cual es el riesgo de perder actividades industriales estrategicas debido a la amenaza de nuevos entrantes en el sector? ? Y? como me puedo proteger?
Predictive painting of 3‐D seismic volumes (2008)

Structural information is the most important content of seismic images. I introduce a numerical algorithm for spreading information in 3‐D volumes according to the local structure of seismic events. The algorithm consists of two steps. First, local, spatially‐variable slopes of seismic events are estimated (inline and crossline in 3‐D) by the plane‐wave‐destruction method. Next, a seed trace is inserted in the volume, and the information contained in that trace is spread inside the volume, thus automatically “painting” the data space. Immediate applications of this technique include automatic horizon picking and flattening in applications to both prestack and post‐stack seismic data. Synthetic and field data tests demonstrate the effectiveness of predictive painting.
Instrumented Footwear for Interactive Dance (1998)

The present paper illustrates our attempt to design and test the reproducibility of low-cost patient positioning devices prepared in-house in our radiotherapy department. Rigid thermocole boards with angulations, scales and support were designed as breast, pelvis and head positioning devices. Reproducibility and accuracy were tested by serial electronic portal imaging detector imaging.The positioning devices (with or without superimposed moulds) showed variations within 2-3 mm on serial treatment days which were within acceptable limits.It is therefore concluded that low-cost patient positioning devices for head, breast and pelvis (the common sites of treatments in radiotherapy) can be fabricated from available materials in-house. These have been shown to be resulting in accurate immobilization, can be customized for particular techniques and are considerably cheaper than commercially available solutions.
The Stereo Implementation (1981)

This chapter contains sections titled: Input, Convolution, Detection and Description of Zero-Crossings, Matching, Vergence Control, The 2½-Dimensional Sketch, Summary of the Process
Identification and Purification of Calcium‐Independent Phospholipase A2 from Bovine Brain Cytosol (1992)

Substantial amounts of phospholipase A2 activity were detected in bovine brain cytosol. The major phospholipase A2 activity was present in the precipitate at 40% saturation with solid ammonium sulfate. After the desaltate of the precipitate was loaded onto an Ultrogel AcA 54 gel filtration column, almost all the activity eluted in the void volume when chromatographed without 1 M KCl. However, when buffer with 1 M KCl was used as the eluent, two active peaks were obtained. One peak (peak I) eluted in the void volume, and the other (peak II) eluted with an apparent molecular mass of 39 kDa as compared with standards. The former was active with diacylglycero-3-phosphoethanolamine, whereas the latter was active with both diacylglycero-3-phosphoethanolamine and 1-alk-1'-enyl-2-acylglycero-3-phosphoethanolamine (plasmenylethanolamine). The apparent molecular mass of peak I was estimated to be 110 kDa as compared with standards on an Ultrogel AcA 34 gel filtration column. Both peaks were purified further with a hydrophobic chromatography column (AffiGel 10 coupled with plasmenylethanolamine) and then by high-resolution liquid chromatography on an MA7Q column. The phospholipase A2 obtained from peak II migrated as one main band with a 40-kDa molecular mass and two minor bands with 14- and 25-kDa molecular masses. Phospholipase A2 obtained from peak I eluted as a single peak on high-resolution liquid chromatography but contained two bands with apparent molecular masses of 100 and 110 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.(ABSTRACT TRUNCATED AT 250 WORDS)
NUBIS (Annales NUmériques de la Bibliographie ISiaque) (2021)

Le programme @NUBIS (Annales NUmeriques de la Bibliographie ISiaque) s’inscrit dans le prolongement actualise et redimensionne de l’Inventaire bibliographique des Isiaca (IBIS) paru dans les annees 1970-1990. Les utilisateurs disposeront alors d’un ensemble de plus de 6000 notices critiques redigees en francais ou en anglais par une equipe internationale de chercheurs, et couvrant l’integralite des publications “isiaques”, depuis l’ouvrage fondateur de Georges Lafaye, “Histoire du culte des divinites d’Alexandrie : Serapis, Isis, Harpocrate et Anubis, hors de l’Egypte depuis les origines jusqu’a la naissance de l’ecole neo-platonicienne”, paru a Paris chez E. Thorin en 1884.
Monitoring Heparin Therapy To Manage Thrombotic Disease (1995)

The acute and long-term management of deep vein thrombosis and thromboembolism are evolving rapidly. The use of unfractionated heparin and low-molecular-weight heparin in such therapy is the focus of this article. Included are current indications, recommended laboratory monitoring approaches, and the shortcomings of basing such recommendations on studies that do not control variables that affect prolongation of the activated partial thromboplastin time. This article is the third in a four-part continuing education series on hematology. Other articles focus on the antiphospholipid syndromes, oral anticoagulants in thromboembolic disease, and thrombolytic therapy. The exam will appear in the May issue.
A dual gradient projection quadratic programming algorithm tailored for model predictive control (2008)

The objective of this work is to derive a QP algorithm tailored for MPC. More specifically, the primary target application is MPC for discrete-time hybrid systems. A desired property of the algorithm is that warm starts should be possible to perform efficiently. This property is very important for on-line linear MPC, and it is crucial in branch and bound for hybrid MPC. In this paper, a dual active set-like QP method was chosen because of its warm start properties. A drawback with classical active set methods is that they often require many iterations in order to find the active set in optimum. Gradient projection methods are methods known to be able to identify this active set very fast and such a method was therefore chosen in this work. The gradient projection method was applied to the dual QP problem and it was tailored for the MPC application. Results from numerical experiments indicate that the performance of the new algorithm is very good, both for linear MPC as well as for hybrid MPC. It is also noticed that the number of QP iterations is significantly reduced compared to classical active set methods.
A review of methods to measure tendon dimensions (2019)

Tendons are soft tissues of the musculoskeletal system that are designed to facilitate joint movement. Tendons exhibit a wide range of mechanical properties matched to their functions and, as a result, have been of interest to researchers for many decades. Dimensions are an important aspect of tendon properties.Change in the dimensions of tissues is often seen as a sign of injury and degeneration, as it may suggest inflammation or general disorder of the tissue. Dimensions are also important for determining the mechanical properties and behaviours of materials, particularly the stress, strain, and elastic modulus. This makes the dimensions significant in the context of a mechanical study of degenerated tendons. Additionally, tendon dimensions are useful in planning harvesting for tendon transfer and joint reconstruction purposes.Historically, many methods have been used in an attempt to accurately measure the dimensions of soft tissue, since improper measurement can lead to large errors in the calculated properties. These methods can be categorised as destructive (by approximation), contact, and non-contact and can be considered in terms of in vivo and ex vivo.
Production of Electricity from Proteins Using a Microbial Fuel Cell (2006)

Electricity generation was examined from proteins and a protein-rich wastewater using a single chamber microbial fuel cell (MFC). The maximum power densities achieved were 354 +/- 10 mW/m2 using bovine serum albumin (BSA) and 269 +/- 14 mW/m2 using peptone (1100 mg/L BSA and 300 mg/L peptone). The recovery of organic matter as electricity, defined as the Coulombic efficiency (CE), was comparable to that obtained with other substrates with CE = 20.6% for BSA and CE = 6.0% for peptone. A meat packing wastewater (MPW), diluted to 1420 mg/L chemical oxygen demand, produced 80 +/- 1 mW/m2, and power was increased by 33% by adding salt (300 mg/L sodium chloride) to increase solution conductivity. A wastewater inoculum generated 33% less power than the MPW inoculum. The MFC was an effective method of wastewater treatment, demonstrated by >86% of biochemical oxygen demand and total organic carbon removal from wastewater.
Stationary Bumps in Networks of Spiking Neurons (2001)

We examine the existence and stability of spatially localized "bumps" of neuronal activity in a network of spiking neurons. Bumps have been proposed in mechanisms of visual orientation tuning, the rat head direction system, and working memory. We show that a bump solution can exist in a spiking network provided the neurons fire asynchronously within the bump. We consider a parameter regime where the bump solution is bistable with an all-off state and can be initiated with a transient excitatory stimulus. We show that the activity profile matches that of a corresponding population rate model. The bump in a spiking network can lose stability through partial synchronization to either a traveling wave or the all-off state. This can occur if the synaptic timescale is too fast through a dynamical effect or if a transient excitatory pulse is applied to the network. A bump can thus be activated and deactivated with excitatory inputs that may have physiological relevance.
Antimicrobial Resistance Incidence and Risk Factors amongHelicobacter pylori–Infected Persons, United States (2004)

Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in the development of gastric cancer. H. pylori infection is curable with regimens of multiple antimicrobial agents, and antimicrobial resistance is a leading cause of treatment failure. The Helicobacter pylori Antimicrobial Resistance Monitoring Program (HARP) is a prospective, multicenter U.S. network that tracks national incidence rates of H. pylori antimicrobial resistance. Of 347 clinical H. pylori isolates collected from December 1998 through 2002, 101 (29.1%) were resistant to one antimicrobial agent, and 17 (5%) were resistant to two or more antimicrobial agents. Eighty-seven (25.1%) isolates were resistant to metronidazole, 45 (12.9%) to clarithromycin, and 3 (0.9%) to amoxicillin. On multivariate analysis, black race was the only significant risk factor (p < 0.01, hazard ratio 2.04) for infection with a resistant H. pylori strain. Formulating pretreatment screening strategies or providing alternative therapeutic regimens for high-risk populations may be important for future clinical practice.
E-045 Separating the Wheat from the Chaff: Completion Angiography Following Complex Aneurysm Repair Using Low-Dose Volume of Interest Plus Metal Artefact Reduction Imaging (2014)

<h3>Introduction</h3> Following complex endovascular or microsurgical treatment of aneurysms, volumetric assessment of the surgical outcome in the angiography suite can be challenging due to device resolution and metallic artefact. We investigated a collimated volumetric imaging protocol followed by metal artefact suppression post processing to evaluate the correct positioning of stents, flow diverting devices, coils, and clips. <h3>Methods</h3> Under an IRB approved study protocol, ten patients who underwent endovascular or surgical treatment of a cerebral aneurysm involving stents, flow-diverting devices, coils, and/or clips, underwent angiography. This consisted of conventional 2D diagnostic imaging, followed by the acquisition of a volume of interest (VOI) collimated DynaCT. Such an acquisition yielded high-spatial resolution of implanted devices, by reducing the radiation burden depending on illuminated detector fraction. Volumetric images were reconstructed, accounting for the truncated images and artefact from dense metallic objects. Blinded readers were presented with VOI 3D images, processed with and without correction for metal artefact, and asked to score overall image quality, visibility of surrounding vasculature and aneurysm inflow, and diagnostic value. Scores were evaluated for statistical significance using a student’s T-test, testing the hypothesis that VOI + MAR is better than VOI alone. <h3>Results</h3> VOI images processed with metal artefact correction were judged better with 95% (p = 0.05) significance for overall image quality and 99% (p = 0.01) for the other three categories. Particular advantage was seen with the identification of residual aneurysm inflow as well as the ability to identify surrounding vasculature. Analysis of VOI scan dose area product (DAP) showed an average reduction of 85% compared to conventional DynaCT. <h3>Conclusion</h3> Combining VOI imaging with metal artefact suppression allows for clear imaging of complex aneurysm repair in the presence of dense metallic objects, while significantly reducing patient radiation exposure. <h3>Disclosures</h3> E. Duckworth: None. D. Hoit: 1; C; Seimens. L. Elijovich: 1; C; Seimens. 2; C; Microvention, Stryker, Codman. V. Doss: None. W. Humphries: None. S. Schafer: 5; C; Seimens Medical Solutions USA. S. Bauer: 5; C; Seimens Medical Solutions USA. A. Arthur: 1; C; Seimens, Terumo. 2; C; Seimens, Johnson and Johnson, Sequent Medical, Covidian, Stryker, Terumo.
Probiotics in Food Systems: Significance and Emerging Strategies Towards Improved Viability and Delivery of Enhanced Beneficial Value (2019)

Preserving the efficacy of probiotic bacteria exhibits paramount challenges that need to be addressed during the development of functional food products. Several factors have been claimed to be responsible for reducing the viability of probiotics including matrix acidity, level of oxygen in products, presence of other lactic acid bacteria, and sensitivity to metabolites produced by other competing bacteria. Several approaches are undertaken to improve and sustain microbial cell viability, like strain selection, immobilization technologies, synbiotics development etc. Among them, cell immobilization in various carriers, including composite carrier matrix systems has recently attracted interest targeting to protect probiotics from different types of environmental stress (e.g., pH and heat treatments). Likewise, to successfully deliver the probiotics in the large intestine, cells must survive food processing and storage, and withstand the stress conditions encountered in the upper gastrointestinal tract. Hence, the appropriate selection of probiotics and their effective delivery remains a technological challenge with special focus on sustaining the viability of the probiotic culture in the formulated product. Development of synbiotic combinations exhibits another approach of functional food to stimulate the growth of probiotics. The aim of the current review is to summarize the strategies and the novel techniques adopted to enhance the viability of probiotics.
The ColorTable (2008)

The paper describes the design story of the ColorTable, a tangible user interface in support of urban planners and diverse stakeholders collaboratively envisioning urban change, which was developed in an iterative process of design-evaluation-feedback-redesign in a series of workshops with users in the context of real urban planning projects. It seeks to clarify a number of more general design issues related to tangible user interfaces -- how to make use of material and spatial properties in designing both, physical interface and multiple and simultaneous interactions; how to handle the complexity of urban projects while keeping interfaces and interactions simple and transparent.