gebhart/patrepeval huggingface dataset:
Diagnose: Confirmation bias. Wie die anfängliche Überzeugtheit von einer klinisch-psychologischen Prüfhypothese, die Berufserfahrung und das Fachwissen die Validität klinischer Diagnosen beeinflussen. (2012)

A new near-infrared (NIR)-emitting aza-boron-dipyrromethene dye with two electron-donating amino groups at 1- and 7-positions has been prepared via several steps of reactions. This probe showed a NIR absorption at 748 nm with an obvious shoulder peak at 634 nm in CH<sub>3</sub>CN/H<sub>2</sub>O. Interestingly, a NIR fluorescence emission at 843 nm was observed with a large Stokes shift of 95 nm. This novel NIR-emitting aza-boron-dipyrromethene dye was further investigated as a Hg<sup>2+</sup>-sensing fluorescent probe, which selectively bound to Hg<sup>2+</sup>, showing a blue-shifted and sharp absorption band at 695 nm with the disappearance of the shoulder peak at 634 nm. Correspondingly, the color change could be easily seen from blue to green. Interestingly, the emission exhibited an absolutely "turn-on" peak at 725 nm with a significant blue shift by 118 nm (from 843 to 725 nm), due to the efficient inhibition of the intramolecular-charge-transfer process arising from two amino groups. This probe was finally introduced to Hela cells, showing a "OFF-ON" NIR emission upon exposure to Hg<sup>2+</sup>. The overall results confirmed that this novel NIR-emitting aza-boron-dipyrromethene fluorescent probe with a large Stokes shift could serve as a colorimetric and fluorescent "turn-on" sensor for Hg<sup>2+</sup> in both solutions and living cells.
Sedimentation of a suspension of paramagnetic particles in an external magnetic field (2020)

We investigate the sedimentation of initially packed paramagnetic particles in the presence of a homogeneous external magnetic field, in a Hele-Shaw cell filled with water. Although the magnetic susceptibility of the particles is small and the particle-particle-induced magnetic interactions are significantly smaller compared to the gravitational acceleration, we do observe a measurable reduction of the decompaction rate as the amplitude of the applied magnetic field is increased. While induced magnetic dipole-dipole interactions between particles can be either attractive or repulsive depending on the particles relative alignment, our observations reveal an effective overall enhancement of the cohesion of the initial pack of particles due to the induced interactions, very likely promoting internal chain forces in the initial pack of particles. The influence of the magnetic field on the particles once they disperse after being decompacted is, however, found to remain marginal.
Peanut allergens are rapidly transferred in human breast milk and can prevent sensitization in mice (2014)

The low quantities of immunologically active allergens transferred through breast milk may prevent instead of priming allergic sensitization to peanut.
A new class of disordered elements controls DNA replication through initiator self-assembly (2019)

SUMMARY The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co-assemble to load the Mcm2-7 replicative helicase onto chromatin. Current replication models envisage a linear arrangement of isolated origins functioning autonomously; the extent of inter-origin organization and communication is unknown. Here, we report that the replication initiation machinery of D. melanogaster unexpectedly undergoes liquid-liquid phase separation (LLPS) upon binding DNA in vitro . We find that ORC, Cdc6, and Cdt1 contain intrinsically disordered regions (IDRs) that drive LLPS and constitute a new class of phase separating elements. Initiator IDRs are shown to regulate multiple functions, including chromosome recruitment, initiator-specific co-assembly, and Mcm2-7 loading. These data help explain how CDK activity controls replication initiation and suggest that replication programs are subject to higher-order levels of inter-origin organization.
Sacral Fractures After Lumbosacral Fusion: A Characteristic Fracture Pattern (2011)

Sacral fractures after lumbosacral fusion have a characteristic transverse pattern through the sacral screw holes that differs from the configuration of more common sacral insufficiency fractures. Most of these fractures occur within 3 months after surgery, and many of the patients need additional surgical fixation. Because few of the patients had osteoporosis and most underwent long fusion, the fractures might have been caused by hardware-related stress raisers in the sacrum.
High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy (2010)

These studies provide a clear biological rationale to test anti-IGF-IR/InsR therapy in combination with chemotherapy in patients with TNBC.
Property Verification for Generic Access Control Models (2008)

To formally and precisely capture the security properties that access control should adhere to, access control models are usually written to bridge the rather wide gap in abstraction between policies and mechanisms. In this paper, we propose a new general approach for property verification for access control models. The approach defines a standardized structure for access control models, providing for both property verification and automated generation of test cases. The approach expresses access control models in the specification language of a model checker and expresses generic access control properties in the property language. Then the approach uses the model checker to verify these properties for the access control models and generates test cases via combinatorial covering array for the system implementations of the models.
Configurable arithmetic arrays with data-driven control (2002)

Configurable digital systems offer flexibility that leads to cost reduction, performance tuning, and fault tolerance. While one can use FPGA-based methods to synthesize configurable arithmetic structures, this approach results in limited functionality and/or excessive complexity, given that off-the-shelf FPGAs are endowed with only bit-level computational capabilities. Using serial arithmetic cells can increase the ratio of resources devoted to computation (arithmetic, logic) versus communication (wiring), thereby improving per-chip performance or cost-effectiveness. When combined with pipelining, even the absolute latency can be improved. We argue that a controlled-precision digit-serial additive multiplier constitutes an ideal building block for configurable arithmetic arrays and detail our solutions for control of functionality, selection of precision, and reduction of power dissipation within such an array.
Fabrication and characterization of high-Q conical polymeric microcavities (2010)

In this work we present the fabrication and characterization of high-Q microresonators made of low loss, thermoplastic polymer poly(methyl methacrylate) (PMMA), which are directly processed on a silicon substrate. Using this polymer-on-silicon material in combination with a thermal reflow step enables cavities of conical shape and ultra smooth surface, dramatically reducing the optical losses caused by surface scatting of the whispering-gallery-modes (WGMs). The cavity Q factor is above two million in the 1300 nm wavelength range and can theoretically reach values up to ten million in the visible. Finite element simulations show the existence of a variety of higher order radial and axial WGMs explaining the complexity of the transmission spectra measured using a tunable diode laser coupled to a tapered optical fiber waveguide.
Tragacanth solutions. I. The relation of method of preparation to the viscosity and stability. (1958)

Various factors which influence the viscosity of tragacanth solutions are discussed. The effects of homogenization and heat on solutions of the gum are reported. The degree of initial hydration of the gum is related to the viscosity changes that occur during aging. This viscosity may first increase and then decrease, or it may solely decrease. Studies of the viscosity changes that occur over relatively long periods of time show that the magnitude of such changes may be predicted by methods which are outlined in this paper.
Benzoate treatment and the glycine index in nonketotic hyperglycinaemia (2004)

High-dose benzoate treatment aimed at reducing plasma glycine levels to normal reduces seizures and increases wakefulness in patients with nonketotic hyperglycinaemia (NKH). Since benzoate metabolism is dependent on the available glycine pool, and since the glycine pool is variably affected by the deficiency in the glycine cleavage enzyme system, we examined the importance of interpatient variability in benzoate requirement. To correct for the dietary glycine contribution, the glycine index was introduced as the molar requirement of benzoate dose necessary to normalize plasma glycine levels and subtracting from that the dietary glycine intake, both corrected for weight. The glycine index varied between 3.62 and 4.87 mmol/kg per day in five patients with a poor neurodevelopmental outcome and between 0.92 and 1.90 mmol/kg per day in four patients with a better neurodevelopmental outcome, and was 2.54 mmol/kg per day in a single patient with an intermediate outcome. The glycine index was stable over time within each patient. Exceeding the balance by either increasing food glycine intake or decreasing the benzoate dose resulted in increased glycine levels. Exceeding the glycine tolerance by increasing benzoate resulted in elevated and toxic levels of benzoate. The glycine index is a stable, individually specific parameter in patients with NKH. It has clinical consequences for the dose of benzoate required and the role of dietary management. Through its correlation with neurodevelopmental outcome, the glycine index points to potential genetic factors that could contribute to the psychomotor retardation in NKH.
Children and air pollution monitoring (2022)

<b>Background:</b> Personal monitoring is now becoming popular both as a research tool and from a health promotion perspective. We have previously reported the exposure profiles of children from the UK using MicroAethalometer (1). These results have formed the basis of intervention studies to reduce the pollution exposure of children (2). We sought to explore the differences in air pollution exposure in two further countries where monitoring has to date been limited. <b>Methods:</b> As part of the CAPPA pilot study we recruited children aged 8-12 years in two countries (Tanzania and South Africa). The MicroAeth was used to collect 24 black carbon (BC) monitoring results alongside activity diaries. An example of the monitoring period is shown in Figure 1. <b>Results:</b> A total of 50 children underwent personal BC monitoring over a 24-hour period (25 from each country). There were significantly higher levels of 24 h total BC in South Africa compared to Tanzania 4857578 µg/m3&nbsp;(SD 3536163) vs 3189485 µg/m3&nbsp;(SD 1828896.3), P&lt;0.05. Similarly, there were significantly higher number of peaks greater than 50000 µg/m3, 12.8 (SD 22.4) vs 3.2 (SD 4), p&lt;0.05. <b>Discussion</b> This first look at pollution exposure in these two countries demonstrates further differences of pollution exposure of children across the world. There are clearly differences in sources of pollution in both countries and this could account for the differences. The next step will be to look at microenvironments of the pollution exposure to look for comparisons to the data previously reported in the UK (3).
A kinetic and isotopic study of the decomposition of monoperoxyphthalic acid (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA kinetic and isotopic study of the decomposition of monoperoxyphthalic acidRichard E. Ball, John Oelhaf. Edwards, Max L. Haggett, and Peter. JonesCite this: J. Am. Chem. Soc. 1967, 89, 10, 2331–2333Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/ja00986a015https://doi.org/10.1021/ja00986a015research-articleACS PublicationsRequest reuse permissionsArticle Views473Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figure 7 from Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth (2023)

Supplementary Figure 7 from Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
Nailing down multi-touch: anchored above the surface interaction for 3D modeling and navigation (2012)

visualization. Center: A user bends a mesh while simultaneously specifying the curvature of the bend. Right: A user twists a 3D mesh by placing his hands on top of each other and rotating. (A digital rendering is superimposed to illustrate the stereoscopic effect of the display.) We present anchored multi-touch, a technique for extending multi-touch interfaces by using gestures based on both multi-touch sur-face input and 3D movement of the hand(s) above the surface. These interactions have nearly the same potential for rich, expres-sive input as do freehand 3D interactions while also having an ad-vantage that the passive haptic feedback provided by the surface makes them easier to control. In addition, anchored multi-touch is particularly well suited for working with 3D content on stereo-scopic displays. This paper contributes two example applications: (1) an interface for navigating 3D datasets, and (2) a surface bend-ing interface for freeform 3D modeling. Two methods for sensing the gestures are introduced, one employing a depth camera.
Highly Enhanced Photoreductive Degradation of Perchlorinated Compounds on Dye-Sensitized Metal/TiO2 under Visible Light (2002)

This study reports an example of visible-light photocatalyst based on TiO2 modified by ruthenium-complex sensitizers and noble metal deposits. The photodegradation of trichloroacetate (TCA) and carbon tetrachloride was used as a probe reaction for evaluating the visible light activity of the photocatalyst under the illumination of λ > 420 nm. Photodeposition of platinum nanoparticles on dye-sensitized TiO2 (Pt/TiO2/RuIIL3) drastically enhanced the degradation rate of TCA and CCl4. The visible light reactivity of Pt/TiO2/RuIIL3 was optimal with [RuIIL3] = 10 μM, [TiO2] = 0.5 g/L, and Pt loading of about 0.2 wt %. Although no electron donors to regenerate the oxidized Ru-sensitizers were added in the aqueous suspension, the photoreductive dechlorination of perchlorinated compounds proceeded far beyond the stoichiometric limit of the initial sensitizer concentration. Water acted as an electron donor to regenerate the sensitizer with a concurrent production of dioxygen. On the other hand, Pt/TiO2/RuIIL3 was completely inactive in the presence of dissolved oxygen and the in-situ generated dioxygen gradually decelerated the dechlorination rate. Conduction band electrons transferred to O2 in preference to CCl4 and TCA on Pt deposits. Other noble metals (Ag, Au, and Pd) deposited on TiO2 showed a better oxygen-tolerance but less visible-light reactivity than Pt/TiO2/RuIIL3. Effects of metal loading on the visible light activity and its implications for the efficient visible-light photocatalyst development are discussed.
Inhibition of bacterial adherence to hydrocarbons and epithelial cells by emulsan (1983)

Acinetobacter calcoaceticus RAG-1 and BD413, as well as Streptococcus pyogenes M-5, adhered to octane. Adherence was inhibited by emulsan (100 micrograms/ml), the polymeric emulsifying agent produced by A. calcoaceticus RAG-1. Emulsan also inhibited adherence of S. pyogenes and RAG-1 to buccal epithelial cells. The mean values of bound S. pyogenes per epithelial cell were 57.2 and 20.7 for the control and emulsan-containing suspensions, respectively; mean values of bound RAG-1 per epithelial cell were 221 for the control and 40 for the suspension containing 100 micrograms of emulsan per ml. Desorption of previously bound RAG-1 from epithelial cells by emulsan was concentration dependent: a maximum of 80% desorption was obtained with 200 micrograms of emulsan per ml. The data showing that emulsan desorbed 70% of the indigenous bacterial flora from buccal epithelial cells suggest that hydrophobic interactions mediate not only the in vitro adherence of laboratory strains to epithelial cells, but actually govern the adherence of the majority of the bacteria that colonize this surface. The advantages of using emulsan as an antiadherence agent include its chemical purity, stability, and polymeric nature.
Static RAM cell for ternary logic (1984)

A novel CMOS static RAM cell for ternary logic systems is described. This cell is based on the lambda diode. The operation of the cell has been simulated using the SPICE 2G program. The results of the simulation are given.
Working conditions for a influencing factor on the performance of adaptive ofdm system under a varying channel (2004)

A main issue in wireless communications is to improve the transmission quality of service (QoS), which may be represented by the bit error rate (BER). In [H. Che, et al., 2002] we studied the combining effect of channel situation and OFDM modulation on BER performance and defined a factor P/sub FR/ based on both OFDM parameter and channel parameter that influences BER performance. But this parameter doesn't influence BER in all the situations. In this paper we find out by simulation results that the factor PFR is effective on BER within a certain range of signal to noise ratio (SNR). And our simulation results indicate that this SNR range is different for different Rician K factor and for different modulation levels. This paper demonstrates that for each modulation level there is a relationship between the effective SNR range and Rician K factor and gives out the formula to describe the relationship. The result is quite useful to build up an optimum criteria for adaptive OFDM systems.
Pressure dependence ofCo60diffusion in amorphousCo76.7Fe2Nb14.3B7 (1992)

The pressure dependence of $^{60}\mathrm{Co}$ diffusion has been measured in melt-spun amorphous ${\mathrm{Co}}_{76.7}$${\mathrm{Fe}}_{2}$${\mathrm{Nb}}_{14.3}$${\mathrm{B}}_{7}$ and fcc Co, and the temperature dependence and the relaxation behavior were investigated in the metallic glass. A radio-tracer technique in conjunction with ion-beam sputtering for serial sectioning was employed. The samples were characterized by means of differential scanning calorimetry, electron microprobe analysis, and x-ray diffraction prior to and after the diffusion anneals. Within the experimental error margins, no pressure dependence was observed in amorphous ${\mathrm{Co}}_{76.7}$${\mathrm{Fe}}_{2}$${\mathrm{Nb}}_{14.3}$${\mathrm{B}}_{7}$. The activation volume was found to be V=-(0.06\ifmmode\pm\else\textpm\fi{}0.1)\ensuremath{\Omega}, where \ensuremath{\Omega} is the atomic volume of Co. This result shows that diffusion in the metallic glass is not mediated through quasivacancies in thermal equilibrium.
Monopole antennas for microwave catheter ablation (1996)

We study the characteristics of various monopole antennas for microwave catheter ablation of the endocardium. The investigation is done with a computer model based on the finite-element method in the frequency domain. Three monopole geometries are considered: open-tip, dielectric-tip, and metal-tip. Calculations are made for the magnetic field, the reflection coefficient and the power deposition pattern of the antennas immersed in normal saline. The theoretical results are compared with measurements performed on prototypes and good agreement Is obtained. The antenna characteristics suggest that the metal-tip monopole best fulfils the requirements of catheter ablation. The computer model is then used to compare metal-tip monopoles of different dimensions and to determine design trade-offs.
Preparation of Cheddar Cheese at Elevated Temperatures (1986)

Reduction of Cheddar cheese making time was investigated by regulating the amount of lactic starter culture initially added to the milk and preparing the cheese at 37.8 C. Laboratory trials showed that in conventional cheese making at 31.1C, an initial cell count of 107 cfu/ml was necessary to achieve a 109 cfu/g population density and desirable acidity (pH 5.3 to 5.4)at the milling stage. In the modified process, cheese curd was prepared by prewarming milk to 37.8C and adding starter culture at 10 s cfu/ml and milk coagulant (veal rennet) simultaneously. This method shortened preparation time by as much as 90 min, depending on the acid production of the starter culture. Cheeses made in six trials were stored at 4.4C for 1 yr. Ratings by an expert panel showed no significant differences in flavor, body, and texture characteristics that could be attributed to the method of preparation. On a 5-point intensity scale, increase in sharpness correlated significantly (P~<.05) with storage time with slightly greater increase observed in the experimental cheese. No difference in sharpness was significant between samples made by conventional and experimental methods. Decline in curdiness with storage time showed similar correlations. The results suggested that reduction of make time by increasing starter culture inoculum to 10 s cfu/ml and renneting at the time of setting at a higher temperature (37.8C) improved aging characteristics of the finished cheese over the storage time studied.
Chondroitin Sulfate and Sulfur Containing Chondroprotective Agents: Is there a Basis for their Pharmacological Action? (2006)

Chondroitin sulfate, glucosamine sulfate and other sulfur containing compounds are widely used by individuals afflicted with joint pains. In spite of their incremental use, neither their efficacy nor their mode of action has been defined. Metabolic studies indicate that these compounds are degraded prior to absorption or shortly thereafter into their fundamental constituents: simple carbohydrates and inorganic sulfate. Polysaccharides cannot be reutilized as such, and inorganic sulfate can only be incorporated into cartilage glycosaminoglycans (GAG) following de novo activation. The carbohydrate moiety of GAG can, under normal circumstances, be readily synthesized by cells. If these compounds, rich in sulfur, are exhibiting any pharmacological effects, they are most likely doing so solely because of their ability to contribute this important element to our organism. Sulfur is normally derived from methionine and cysteine in proteins. Very little is derived from other dietary sources. The minimal daily requirements for this important mineral have never been established in spite that in addition to being essential for GAG synthesis, it is a structural component of glutathione and other key enzymes, coenzymes and metabolites that play fundamental roles in cellular homeostasis and control of inflammation. It is therefore not unlikely that any beneficial effect of these dietary supplements results from their ability to supplement our diet with a source of inorganic sulfur.