gebhart/patrepeval huggingface dataset:
Improving gait performance in Parkinson's disease by interpersonal synchrony-based dynamic stabilization (2012)

Previously, research on gait control has mainly focused on interpersonal synchrony and locomotor control. However their intersection, the interpersonal synchronization of stepping rhythms which is widely observed in our daily life, remains relatively unexplored, despite being a common phenomenon that has considerable rehabilitation potential. Therefore, from the perspective of mutual entrainment of gait rhythms, we have constructed an interpersonal synchrony emulation system between a human subject and a biped virtual robot that generates pacing signal cues using nonlinear oscillators. This system synchronizes the stride interval times of a human and the robot in a cross-feedback manner; by presenting auditory stimulation that indicates the timing of the partner's foot contacting the ground. Here, we evaluated the effectiveness of the system in gait stabilization of twenty-one Parkinson's disease (PD) patients, who previously displayed disturbances in rhythm formation and festinating gait (accelerating steps). The results showed that the festinating gait, as measured as stride time reduction rate, significantly stabilized and accelerated less with the system compared to unassisted walking. Additionally, significant carry-over effects were observed. After termination of the auditory stimulation, the gait remained stabilized. Our previous pilot study suggested that the gait of PD patients was dynamically stabilized by applying the inter personal synchrony process between the timing of human's gait and of external auditory cues. In this paper, we showed significant improvement for the festinating gait in twenty one PD patients.
A novel mid-infrared gas sensor based on mutually coupled quantum cascade lasers (2017)

Since many molecules possess their specific fingerprint in the mid-infrared (MIR) wavelength regime, MIR absorption spectroscopy is a powerful technique to determine the composition and species concentration of an unknown substance [1]. Due to the broad MIR-wavelength operation regime from 2.63 μm up to 250 μm, the high quantum efficiency and the customizable output wavelength, Quantum Cascade Lasers (QCLs) introduced in 1994 [2], are the most appropriate choice for this wavelength range.
Observations on Human Subjects Living in a "Slow Rotation Room" for Periods of Two Days (1960)

This report describes a new stressful procedure and the constellation of symptoms manifested by persons subjected to this stress. The procedure consists essentially of carrying out activities in a slowly rotating room. The symptoms most nearly resemble those observed in motion sickness,<sup>4,15,22</sup>but certain similarities are also seen when comparison is made with the symptomatology in vasodepressor states,<sup>5,21</sup>in anxiety and depressive states, in sleep, and, indeed, in various disturbances characterized by psychosomatic symptoms.<sup>20</sup>Inasmuch as the symptoms are the direct or indirect result of stimulation of the semicircular canals, the most precise term covering the general symptomatology is probably "canal sickness."<sup>8</sup>Although the procedure is specifically applicable to studies of the function of the semicircular canals, it has additional usefulness as a means of investigating certain aspects of the brain stem-activating system.<sup>3,6,10,11,14,17</sup>The extraordinary flexibility of the procedure in terms of both the strength
Unshackle the cloud (2011)

Infrastructure-as-a-Service (IaaS) clouds are evolving from offering simple on-demand resources to providing diverse sets of tightly-coupled monolithic services. Like OS kernels of the 1980's and 1990's, these monolithic offerings, albeit rich in features, are significantly constraining users' freedom and control over the underlying-- cloud--resources. For example, we are unaware of a true hybrid cloud, where its users can migrate virtual machines freely across clouds. This paper argues for a new type of IaaS cloud, an xCloud, that builds on ideas from extensible OSs to give users the flexibility to install custom cloud extensions, which can address the limitations outlined above. We describe the design space for xClouds, including a practical approach for transforming today's public clouds into xClouds.
PIKfyve Lipid Kinase Is a Protein Kinase:  Downregulation of 5‘-Phosphoinositide Product Formation by Autophosphorylation (2000)

A subset of phosphoinositide 3-kinase family members are dual specificity enzymes; their protein kinase activity is thought to bring about an additional level to their intracellular regulation. Here we have examined whether the 5'-phosphoinositide kinase PIKfyve, reported previously to catalyze the formation of PtdIns 5-P and PtdIns 3,5-P(2) in vitro [Sbrissa et al. (1999) J. Biol. Chem. 274, 21589-21597], displays dual specificity. We now report that PIKfyve possesses an intrinsic protein kinase activity inseparable from its lipid kinase activity and, besides itself, can phosphorylate exogenous proteins in a substrate-specific manner. Both the autophosphorylation and transphosphorylation were demonstrated with PIKfyve immunopurified or affinity-purified from heterologously transfected COS cells, infected Sf9 cells, or native 3T3-L1 adipocytes. Conversely, no protein kinase activity was associated with immunopurified lipid kinase dead point (K1831E) or truncated (Delta1812-2052) PIKfyve mutants. PIKfyve autophosphorylation or transphosphorylation engaged Ser but not Thr or Tyr residues. PIKfyve autophosphorylation was largely abrogated upon pretreatment with PIKfyve lipid substrates or phosphatases. The impact of autophosphorylation on the PIKfyve lipid kinase activity was further examined with purified PIKfyve preparations. A decrease of 70% in the lipid product formation was associated with PIKfyve autophosphorylation, which was reversed upon treatment with phosphatases. In the cellular context, PIKfyve, or a fraction of it, was found in a phosphorylated form. Collectively, these results indicate that PIKfyve is a dual specificity kinase, which can generate and relay protein phosphorylation signals to regulate the formation of its lipid products, and possibly other events, in the context of living cells.
Protein specific N-glycosylation of tyrosinase and tyrosinase-related protein-1 in B16 mouse melanoma cells (1999)

Tyrosinase and tyrosinase-related protein-1 (TRP-1) are two melanogenic enzymes that regulate melanin biosynthesis. Both are glycoproteins and belong to the TRP-1 gene family. They share a significant level of sequence similarity in several regions, including the catalytic domain and the potential N-glycosylation sites. We have recently shown that inhibition of the early steps of N-glycan processing in B16F1 cells dramatically affects tyrosinase activity and melanin synthesis. We present here results on N-glycan processing of TRP-1 and tyrosinase and compare the maturation process and activity of both glycoproteins in the presence of inhibitors of the endoplasmic reticulum stages of N-glycosylation.N-glycan analysis reveals that each of these two glycoproteins contains a mixture of high-mannose and sialylated complex N-glycans. However, in contrast to TRP-1, tyrosinase presents a homogeneous high-mannose glycoform, also.In the presence of α-glucosidases inhibitors, the maturation of tyrosinase N-glycans is completely inhibited, whereas TRP-1 is still able to acquire some complex glycans, indicating that endomannosidase acts preferentially on the later glycoprotein. In addition, the dopa-oxidase activity of tyrosinase is totally abolished, whereas for TRP-1 it is only partially affected. The results suggest that despite their structural similarity, tyrosinase is more sensitive than TRP-1 to perturbations of early N-glycan processing, in terms of maturation and catalytical activity.
Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins. (1992)

Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer formation and normal cell surface expression of these receptors, leading to life-threatening bacterial infections. To elucidate the nature of these defects in a patient with partial (type II) deficiency, abnormal CD18 cDNA clones were isolated, using the polymerase chain reaction to amplify the patient's B cell-derived cDNAs. Sequence analysis revealed two mutant alleles. cDNA clones, representing a maternal allele, contained both a 12-base pair insertion resulting in an in-frame addition of four amino acids between P247 and E248 and a C1756----T nucleotide transition, resulting in an R586----W substitution in the normal CD18 protein. The inframe insertion arose by a single nucleotide C----A transversion in the 3' terminus of an intron, generating aberrant splice acceptor site. Other cDNA clones contained an A1052----G nucleotide transition not present in either parent which resulted in an N351----S substitution. To determine the functional importance of these changes, cDNA encoding a normal alpha chain (CD11b) was cotransfected into COS with CD18 cDNAs encoding for wild-type, maternal mutant allele, or CD18 containing N351----S substitution. Immunostaining of transfectants with anti-CD18 monoclonal antibodies revealed no cell surface expression of the maternal mutant CD18, and 22% surface expression of N351----S CD18. Both the insertion and the N351----S mutations occurred in a 250 amino acid extracellular region of CD18 that is highly conserved among beta integrins supporting a role for this region in heterodimer formation.
Data from Cannabidiol Enhances the Inhibitory Effects of Δ<sup>9</sup>-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival (2023)

&lt;div&gt;Abstract&lt;p&gt;The cannabinoid 1 (CB&lt;sub&gt;1&lt;/sub&gt;) and cannabinoid 2 (CB&lt;sub&gt;2&lt;/sub&gt;) receptor agonist Δ&lt;sup&gt;9&lt;/sup&gt;-tetrahydrocannabinol (THC) has been shown to be a broad-range inhibitor of cancer in culture and &lt;i&gt;in vivo,&lt;/i&gt; and is currently being used in a clinical trial for the treatment of glioblastoma. It has been suggested that other plant-derived cannabinoids, which do not interact efficiently with CB&lt;sub&gt;1&lt;/sub&gt; and CB&lt;sub&gt;2&lt;/sub&gt; receptors, can modulate the actions of Δ&lt;sup&gt;9&lt;/sup&gt;-THC. There are conflicting reports, however, as to what extent other cannabinoids can modulate Δ&lt;sup&gt;9&lt;/sup&gt;-THC activity, and most importantly, it is not clear whether other cannabinoid compounds can either potentiate or inhibit the actions of Δ&lt;sup&gt;9&lt;/sup&gt;-THC. We therefore tested cannabidiol, the second most abundant plant-derived cannabinoid, in combination with Δ&lt;sup&gt;9&lt;/sup&gt;-THC. In the U251 and SF126 glioblastoma cell lines, Δ&lt;sup&gt;9&lt;/sup&gt;-THC and cannabidiol acted synergistically to inhibit cell proliferation. The treatment of glioblastoma cells with both compounds led to significant modulations of the cell cycle and induction of reactive oxygen species and apoptosis as well as specific modulations of extracellular signal-regulated kinase and caspase activities. These specific changes were not observed with either compound individually, indicating that the signal transduction pathways affected by the combination treatment were unique. Our results suggest that the addition of cannabidiol to Δ&lt;sup&gt;9&lt;/sup&gt;-THC may improve the overall effectiveness of Δ&lt;sup&gt;9&lt;/sup&gt;-THC in the treatment of glioblastoma in cancer patients. Mol Cancer Ther; 9(1); 180–9&lt;/p&gt;&lt;/div&gt;
Hyperoxia and neonatal brain injury (2005)

Advances in perinatal care have led to marked improvement in survival rates of premature infants. Neurologic morbidity of these children, however, has not decreased at the same pace.
A Vibration-Based MEMS Piezoelectric Energy Harvester and Power Conditioning Circuit (2014)

This paper presents a micro-electro-mechanical system (MEMS) piezoelectric power generator array for vibration energy harvesting. A complete design flow of the vibration-based energy harvester using the finite element method (FEM) is proposed. The modal analysis is selected to calculate the resonant frequency of the harvester, and harmonic analysis is performed to investigate the influence of the geometric parameters on the output voltage. Based on simulation results, a MEMS Pb(Zr,Ti)O3 (PZT) cantilever array with an integrated large Si proof mass is designed and fabricated to improve output voltage and power. Test results show that the fabricated generator, with five cantilever beams (with unit dimensions of about 3 × 2.4 × 0.05 mm3) and an individual integrated Si mass dimension of about 8 × 12.4 × 0.5 mm3, produces a output power of 66.75 μW, or a power density of 5.19 μW∙mm-3∙g-2 with an optimal resistive load of 220 kΩ from 5 m/s2 vibration acceleration at its resonant frequency of 234.5 Hz. In view of high internal impedance characteristic of the PZT generator, an efficient autonomous power conditioning circuit, with the function of impedance matching, energy storage and voltage regulation, is then presented, finding that the efficiency of the energy storage is greatly improved and up to 64.95%. The proposed self-supplied energy generator with power conditioning circuit could provide a very promising complete power supply solution for wireless sensor node loads.
Solar Energy Harvesting on S- and N-doped nanoporous Carbons (2015)

Nowadays heteroatom-containing carbonaceous materials such as graphene or CNT have gained more and more attention of the scientists searching for inexpensive substitutes of the catalysts for energy related applications such an oxygen reduction reactions. Discovery of graphene and an extensive characterization of its electronic properties caused that the surface of traditional activated carbon has been viewed from other, unexplored before, angles. The main advantage of activated or nanoporous carbons, within the family of carbonaceous materials, is their porosity where the confined pore space effect can be utilized. Recently we have shown that specific nanoporous carbons obtained from commodity polymers can catalyze oxygen evolution reactions1, oxygen reduction reaction2 and exhibit photoluminescence properties3. This behavior was attributed to the specificity of surface microstructure, texture, and chemistry. It was found that the carbons obtained at relatively low temperature (800 oC) contain 10 nm graphic units enhancing their DC conductivity. They have also rich surface chemistry based on sulfur, nitrogen and oxygen containing groups. Even though small sp2 clusters should be important to affect the width of the band gap, the sulfur and nitrogen containing groups are hypothesized to act as chromophores/antenna accepting visible light energy. Electron deficiency on them promotes water splitting in small pores. These groups also change the electronic structure of the carbons surface and bring some level hydrophobicity to it. These features were found as important for oxygen reduction reactions4. These reactions enhance the performance of carbons as supercapcitors when the process takes place in the visible light5. References 1. Ania, C.O.; Seredych, M.; Rodriguez-Castellon, E.; Bandosz, T.J. Visible light driven photoelectrochemical water splitting on metal free nanoporous carbon promoted by chromophoric functional groups. Carbon 79 (2014) 432–441. 2. Seredych, M.; Idrobo, J-C.; Bandosz, T.J. Effect of confined space reduction of graphite oxide followed by sulfur doping on oxygen reduction reaction in neutral electrolyte. J. Mater. Chem. A. 1 (2013) 7059-7067. 3. Bandosz, T.J.; Rodriguez-Castellon, E.; Montenegro J.M.; Seredych, M. Photoluminescence of nanoporous carbons: Opening a new application route for old materials.. Carbon 77 (2014) 651–659. 4. Confined space reduced graphite oxide doped with sulfur as metal-free oxygen reduction catalyst. Seredych, M.; Rodriguez-Castellon, E.; Bandosz, T.J. Carbon 66 (2014) 227-233. 5. Seredych, M.; Rodriguez-Castellon, E.; Biggs, MJ. Skinner, W.l Bandosz, T.J. Effect of visible light and electrode wetting on the capacitive performance of S- and N-doped nanoporous carbons: Importance of surface chemistry. Carbon 78 (2014) 540–558.
Tentative criteria for confirming the in vitro susceptibilities of Haemophilus influenzae and Neisseria gonorrhoeae to two fluoroquinolones (sparfloxacin and levofloxacin), including quality control parameters (1993)

Sparfloxacin and levofloxacin were evaluated against 150 Haemophilus influenzae isolates and 149 Neisseria gonorrhoeae isolates in order to define susceptibility testing parameters. Sparfloxacin-susceptible H. influenzae strains were defined as those for which the MICs were < or = 0.25 microgram/ml and the zones were > or = 30 mm, and N. gonorrhoeae susceptible strains were those for which the MICs were < or = 0.03 microgram/ml and the zones were > or = 39 mm (5-micrograms disks). Levofloxacin-susceptible strains of H. influenzae included those for which the MICs were < or = 0.12 microgram/ml and the zones were > or = 32 mm and N. gonorrhoeae susceptible strains were those for which the MICs were < or = 0.12 microgram/ml and the zones were > or = 37 mm (5-micrograms disks). Criteria for a resistant category cannot yet be defined for either quinolone. In multilaboratory studies with different lots of Haemophilus Test Medium, replicate tests with the standard control strain of H. influenzae (ATCC 49247) were evaluated. For sparfloxacin disk tests, the proposed zone size limits were 33 to 42 mm and broth microdilution MIC limits were 0.004 to 0.016 microgram/ml, whereas for levofloxacin tests, zone size limits were 32 to 41 mm and broth microdilution MIC limits were 0.008 to 0.03 microgram/ml. Other multilaboratory studies evaluated tests with supplemented GC agar and N. gonorrhoeae ATCC 49226; for both drugs, zone size limits were 44 to 52 mm and agar dilution MIC limits were 0.004 to 0.016 microgram/ml.
Blastocyst formation following intracytoplasmic injection of in-vitro derived spermatids into bovine oocytes (1996)

Various types of male gametes, such as spermatozoa, spermatids and spermatids obtained after the in-vitro division of secondary spermatocytes, were injected into the in-vitro matured bovine oocytes in order to examine the possibility of utilizing in-vitro derived spermatids for intracytoplasmic injection. There were no significant differences in the development of bovine oocytes injected with various types of male gametes (cleavage rate, 31.0-37.8%; morula rate, 11.1-18.2%; blastocyst rate, 4.4-1.4%). Similarly, 22.0% of sham-injected oocytes (injection of medium plus polyvinylpyrrolidone) cleaved parthenogenetically but none of them developed to morula stage. There were no significant differences in embryo quality (assessed by cell number) of blastocysts obtained by the injections of various types of male gametes (124.0 +/- 9.6-152.5 +/- 15.5). This study demonstrates that various types of spermatogenic cells can be used for intracytoplasmic injection of oocytes to produce viable embryos.
The Lung Tissue Microbiome in Chronic Obstructive Pulmonary Disease (2012)

There is a detectable bacterial community within human lung tissue that changes in patients with very severe COPD.
“Thiol-ene” photo-cured hybrid materials based on POSS and renewable vegetable oil (2011)

We demonstrate here a series of hybrid materials based on thiol-contained polyhedral oligomeric silsesquioxane (POSS-OA/SH) and acrylated caster oil (ACO), which can be photo-cured through “thiol-ene” reaction. The fast photo-crosslinking reaction between POSS and ACO was traced by FT-IR, which is insensitive to oxygen gas. Compared with the pure ACO, the hybrid component of POSS-OA/SH and ACO exhibited much faster photo-cured speed upon the exposure of UV-light. The obtained hybrid materials were transparent to visible light and no obvious phase-separation was observed. AFM and SEM demonstrated that POSS nanoparticles were well-dispersed in the ACO matrix without obvious aggregation even if the content of POSS is higher than 60%. The introduction of POSS can decrease the surface energy of the obtained hybrid materials. The thermal stability of the obtained hybrid materials increased with the increase of POSS content. These characteristics gave the obtained hybrid material potential application in coating, and these studies provided a novel alternative approach to prepare the hybrid materials from the renewable source.
Reduction of a Cerium(III) Siloxide Complex To Afford a Quadruple‐Decker Arene‐Bridged Cerium(II) Sandwich (2017)

Abstract Organometallic multi‐decker sandwich complexes containing f‐elements remain rare, despite their attractive magnetic and electronic properties. The reduction of the Ce III siloxide complex, [KCeL 4 ] ( 1 ; L=OSi(OtBu) 3 ), with excess potassium in a THF/toluene mixture afforded a quadruple‐decker arene‐bridged complex, [K(2.2.2‐crypt)] 2 [{(KL 3 Ce)(μ‐η 6 :η 6 ‐C 7 H 8 )} 2 Ce] ( 3 ). The structure of 3 features a [Ce(C 7 H 8 ) 2 ] sandwich capped by [KL 3 Ce] moieties with a linear arrangement of the Ce ions. Structural parameters, UV/Vis/NIR data, and DFT studies indicate the presence of Ce II ions involved in δ bonding between the Ce cations and toluene dianions. Complex 3 is a rare lanthanide multi‐decker complex and the first containing non‐classical divalent lanthanide ions. Moreover, oxidation of 1 by AgOTf (OTf=O 3 SCF 3 ) yielded the Ce IV complex, [CeL 4 ] ( 2 ), showing that siloxide ligands can stabilize Ce in three oxidation states.
Einführung (1992)

Die Entwicklung familialer Lebensformen, die Formen des Aufwachsens von Kindern in einer hochindustrialisierten Gesellschaft, die Entwicklung der Beziehungen zwischen den Geschlechtern, der Wandel und die Entwicklung von Lebensverläufen, Partnerschaftsbeziehungen und Prozessen der Lösung aus der Herkunftsfamilie und Gründung einer eigenen Familie, die ökonomische Situation von Familien mit kleinen Kindern sowie die Einstellungen zu Ehe, Kindern und Familie, sind Themen, die gegenwärtig intensiv diskutiert werden. Diese Diskussion wird nicht nur in fachwissenschaftlichen Publikationen geführt, sondern findet in Presse, Medien und Politik eine breite Resonanz.
The effects of the dark energy on the static Schrödinger–Newton system — An Adomian Decomposition Method and Padé approximants based approach (2021)

The Schrödinger–Newton system is a nonlinear system obtained by coupling together the linear Schrödinger equation of quantum mechanics with the Poisson equation of Newtonian mechanics. In this work, we will investigate the effects of a cosmological constant (dark energy or vacuum fluctuation) on the Schrödinger–Newton system, by modifying the Poisson equation through the addition of a new term. The corresponding Schrödinger–Newton-[Formula: see text] system cannot be solved exactly, and therefore for its study one must resort to either numerical or semianalytical methods. In order to obtain a semianalytical solution of the system we apply the Adomian Decomposition Method, a very powerful method used for solving a large class of nonlinear ordinary and partial differential equations. Moreover, the Adomian series are transformed into rational functions by using the Padé approximants. The semianalytical approximation is compared with the exact numerical solution, and the effects of the dark energy on the structure of the Newtonian quantum system are fully investigated.
Supplementary Methods Figure from Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin (2023)

&lt;p&gt;Supplementary Methods Figure 1&lt;/p&gt;