gebhart/patrepeval huggingface dataset:
BaLAnce: Battery Lifetime-Aware LTE Switching-Off Strategy in Green Network Infrastructures (2016)

The load-aware operation of network infrastructure is a well established green networking concept to improve the energy-efficiency of wireless communication networks. But while it has been shown that switching-off base stations in times of low traffic leads to significant savings of energy, the interdependency of such infrastructure-oriented measures on the power consumption of user equipments has not been addressed in detail so far. This paper therefore quantizes the negative impact of switching-off strategies for base stations on the battery lifetime of Long Term Evolution (LTE) devices. Therefore, the Context- Aware Power Consumption Model for LTE devices (CoPoMo) that enables an accurate quantification of the energy efficiency of devices under different network deployments, is leveraged. In order to enable a trade-off between energy savings in the infrastructure and battery lifetimes of devices on the user side, we propose a Battery-Lifetime-Aware switching-off Strategy (BaLAnce) for base stations. The results of a simulation study with a reference LTE network scenario show, that a significantly better energy trade-off can be achieved by BaLAnce.
The NtrY/X two‐component system of Brucella spp. acts as a redox sensor and regulates the expression of nitrogen respiration enzymes (2012)

Summary Brucella spp. are facultative intracellular bacteria pathogenic for many mammalian species including humans, causing a disease called brucellosis. Learning how Brucella adapts to its intracellular niche is crucial for understanding its pathogenesis mechanism, allowing for the development of new and more effective vaccines and treatments against brucellosis. Brucella pathogenesis resides mostly in its ability to adapt to the harsh environmental conditions encountered during host infection such as the oxygen depletion. The mechanism by which Brucella senses the oxygen tension and triggers its environmental adaptation is unknown. In this work we show that the Brucella abortus NtrY/NtrX two‐component system is involved in oxygen sensing through a haem group contained in a Per‐ARNT‐SIM (PAS) domain of the NtrY histidine kinase. The NtrY haem iron can be reduced to the ferrous form and is rapidly oxidized to the ferric form in presence of oxygen. Importantly, we show that the oxidation state of the haem iron modulates the autokinase activity, being the anoxygenic reduced ferrous form the signalling state of NtrY. Also, we show that ntrY gene expression increases under low oxygen tension and that NtrY transfers its signal to its cognate response regulator NtrX, regulating in this way the expression of nitrogen respiration enzymes. Based on these findings, we postulate that NtrY acts as a redox sensor in Brucella spp.
Insensitivity to the bitter taste of chloramphenicol: An autosomal recessive trait. (2002)

Sensitivity to the bitter taste of chloramphenicol was studied in 860 students, 620 males and 240 females. About 8.6% of them were insensitive to this bitter taste. Familial lineage studies were carried out on a subset of these students, and the results suggested that the sensitivity or insensitivity was controlled by a pair of autosomal Mendelian genes, with the sensitive gene being dominant over the insensitive.
User Models & Metrics (2009)

1. What are the common assumptions about user behavior implicit or explicit in common metrics? 2. We identify essentially two classes: I Assume the user effort is fixed and estimate the session success, I Assume the session is successful and estimate the effort. 3. We argue that: I Metrics parameters can be estimated thanks to the associated user model, I It would be better to fix neither utility nor effort (Pareto frontier), I Instead of comparing metrics, we should compare user models.
Optimized solar powered freeze desalination technology (1981)

Tetraspanins are a family of membrane-organizing proteins, characterized by the presence of four highly conserved transmembrane regions that mediate diverse physiological functions. In the current study, we have identified two novel tetraspanin members in rainbow trout (Oncorhynchus mykiss), homologs to mammalian CD9 and CD63. Both genes were expressed in muscle, skin, gills, hindgut, gonad, liver, spleen, head kidney, thymus and peripheral blood leukocytes. Throughout the early life cycle stages, CD9 mRNA levels significantly increased after first feeding, whereas CD63 transcription remained constant during all the developmental stages analyzed. In response to an experimental bath infection with viral hemorrhagic septicemia virus (VHSV), CD9 transcription was down-regulated in the gills, while CD63 mRNA levels were down-regulated in the head kidney. Instead, when the virus was intraperitoneally injected, the transcription of both genes was significantly up-regulated in peritoneal cells at several days post-infection. Additionally, both genes were transcriptionally up-regulated in the muscle of trout injected with a VHSV DNA vaccine. To gain insight on the relation of these tetraspanins with B cell activity we determined their constitutive expression in naive IgM(+) populations from different sources and observed that both molecules were being transcribed by IgM(+) cells in different tissues. Furthermore, CD9 transcription was significantly down-regulated in splenic IgM(+) cells in response to in vitro VHSV exposure. Our results provide insights on the potential role of these tetraspanins on teleost B cell and antiviral immunity.
ChemInform Abstract: An Expedient Synthesis of 3‐Amino‐1,2‐benzisothiazoles. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Distinct transcriptomic cell types and neural circuits of the subiculum and prosubiculum along the dorsal-ventral axis (2019)

Summary Subicular region plays important roles in spatial processing and many cognitive functions and these were mainly attributed to subiculum (Sub) rather than prosubiculum (PS). Using single-cell RNA-sequencing (scRNA-seq) technique we have identified up to 27 distinct transcriptomic clusters/cell types, which were registered to anatomical sub-domains in Sub and PS. Based on reliable molecular markers derived from transcriptomic clustering and in situ hybridization data, the precise boundaries of Sub and PS have been consistently defined along the dorsoventral (DV) axis. Using these borders to evaluate Cre-line specificity and tracer injections, we have found bona fide Sub projections topographically to structures important for spatial processing and navigation. In contrast, PS along DV axis sends its outputs to widespread brain regions crucial for motivation, emotion, reward, stress, anxiety and fear. Brain-wide cell-type specific projections of Sub and PS have also been revealed using specific Cre-lines. These results reveal two molecularly and anatomically distinct circuits centered in Sub and PS, respectively, providing a consistent explanation to historical data and a clearer foundation for future functional studies. Highlights 27 transcriptomic cell types identified in and spatially registered to “subicular” regions. Anatomic borders of “subicular” regions reliably determined along dorsal-ventral axis. Distinct cell types and circuits of full-length subiculum (Sub) and prosubiculum (PS). Brain-wide cell-type specific projections of Sub and PS revealed with specific Cre-lines. In Brief Ding et al. show that mouse subiculum and prosubiculum are two distinct regions with differential transcriptomic cell types, subtypes, neural circuits and functional correlation. The former has obvious topographic projections to its main targets while the latter exhibits widespread projections to many subcortical regions associated with reward, emotion, stress and motivation.
Sécurité des systèmes distribués : apport des architectures logicielles (1998)

Les systemes distribues ouverts sont amenes a supporter l'execution d'un grand nombre d'applications pouvant avoir des contraintes d'execution differentes. Du point de vue de la securite informatique, le challenge pour ces systemes distribues est non seulement de supporter la coexistence de multiples politiques de securite, chaque application pouvant specifier sa propre politique, mais egalement l'interaction entre applications s'appuyant sur ces differentes politiques. Notre travail de these a consiste a proposer une solution a la gestion de la coexistence de differentes politiques de securite, afin de faciliter le developpement de systemes distribues securises. Notre proposition est basee sur la definition des architectures logicielles securisees. Une architecture logicielle securisee comprend la description de l'application en terme d'interconnexion de composants logiciels, ainsi que la specification (formelle) des contraintes de securite de chaque composant. Etant donnee la specification des contraintes de securite de chaque composant logiciel, notre solution consiste, pour chaque interconnexion de composants, a combiner leurs specifications afin de generer les contraintes de securite liees a chacune des interconnexions. Pour cela, nous avons defini un ensemble d'operateurs permettant de combiner les contraintes de securite. L'appariement de specifications formelles est utilise afin de selectionner les composants systeme qui garantissent les contraintes de securite de chaque interconnexion. Finalement, l'utilisation pratique de notre solution est egalement traitee en proposant son integration dans un environnement de developpement d'applications distribuees. Le resultat de cette integration est un environnement facilitant le developpement d'applications distribuees ayant des contraintes de securite.
Platelets of patients with chronic kidney disease demonstrate deficient platelet reactivity in vitro (2012)

In this study we found that patients with chronic kidney disease show reduced platelet reactivity in response of ADP, TRAP and CRP compared to controls. These results contribute to our understanding of the aberrant platelet function observed in patients with chronic kidney disease and emphasize the significance of using functional whole blood platelet activation assays.
Identification of Mitochondrial DNA Variants Associated With Risk of Neuroblastoma (2022)

Neuroblastoma is a childhood cancer that originates in the developing sympathetic nervous system. We previously reported a crucial role of mitochondrial DNA haplogroups in the pathology of neuroblastoma. To pinpoint mitochondrial DNA variants associated with neuroblastoma risk, we applied a mitochondrial genome imputation pipeline to the single nucleotide polymorphisms array data of 2 pediatric cohorts containing a total of 2404 neuroblastoma patients and 9310 cancer-free controls. All statistical tests were 2-sided. The single nucleotide variant, rs2853493, was statistically significantly associated with neuroblastoma risk in the discovery cohort (odds ratio = 0.62, 95% confidence interval = 0.53 to 0.72, P < .001) and further confirmed in the replication cohort (odds ratio = 0.75, 95% confidence interval = 0.62 to 0.90, P = .002). Further, expression quantitative trait loci analysis indicated genotypes of rs2853493 were associated with expression levels of MT-CYB gene expression in neuroblastoma cells, suggesting rs2853493 may confer risk to neuroblastoma via regulating the expression level of its nearby genes.
Ocular and Facial Far‐UVC Doses from Ceiling‐Mounted 222 nm Far‐UVC Fixtures (2022)

Far-UVC radiation, defined in this paper as ultraviolet (UV) radiation with wavelengths from 200 to 235 nm, is a promising tool to help prevent the spread of disease. The unique advantage of far-UVC technology over traditional UV germicidal irradiation lies in the potential for direct application of far-UVC into occupied spaces since antimicrobial doses of far-UVC are significantly below the recommended daily safe exposure limits. This study used a ceiling-mounted far-UVC fixture emitting at 222 nm to directly irradiate an indoor space and then evaluated the doses received upon a manikin. Radiation-sensitive film was affixed to the head, nose, lip and eyes of the manikin, and the 8-h equivalent exposure dose was determined. Variables examined included manikin height (sitting or standing position), manikin offset from directly below the fixture, tilt of the manikin, the addition of glasses, the addition of hair and different anatomical feature sizes. Importantly, at the manikin position with the highest dose to eyes, the average eye dose was only 5.8% of the maximum directly measured dose. These results provide the first experimental analysis of possible exposure doses a human would experience from an indoor far-UVC installation.
Hypovitaminosis D in Patients Scheduled to Undergo Orthopaedic Surgery (2010)

The prevalence of low serum levels of vitamin D among patients undergoing orthopaedic surgery is very common. Given the importance of vitamin D in musculoskeletal health, such low levels may negatively impact patient outcomes.
exo-π-(Benzonorbornadiene)tricarbonylchromium (1995)

The title compound, tricarbonyl[(4a,5,6,7,8,8a-η)-1,4-dihydro-1,4-methanonaphthalene]chromium, [Cr(C 11 H 10 )-(CO) 3 ], is a complex of chromium(0) in which the arene ring of the organic ligand is hexahapto-coordinated to the Cr atom. Three terminal carbonyl ligands form the triangular base of the molecule. The mode of coordination of the Cr(CO) 3 moiety to the ligand is such that the free double bond of the benzonorbomadiene is oriented away from the Cr atom. The chromium-carbonyl tripod is rotated slightly from a perfectly staggered arrangement with respect to the arene ring and, hence, the molecule does not possess a plane of symmetry.
International Liver Transplantation Society Consensus Statement on Hepatitis C Management in Liver Transplant Recipients (2017)

In Brief The ILTS has convened an expert panel to review the approach to management of Hepatitis C Virus in the transplant recipient in the era of direct acting anti-virals. Considerations range from preemption of recurrence to the treatment of fibrosing cholestatic hepatitis.
The Human Factors of an Early Space Accident: Flight 3-65 of the X-15 (2015)

The X-15 was a critical research vehicle in the early days of space flight. On November 15, 1967, the X-15-3 suffered an in-flight breakup. This 191st flight of the X-15 and the 65th flight of this third configuration was the only fatal accident of the X-15 program. This paper presents an analysis, from a human factors perspective, of the events that led up to the accident. The analysis is based on the information contained in the report of the Air Force-NASA Accident Investigation Board (AIB) dated January, 1968. The AIBs analysis addressed, primarily, the events that occurred subsequent to the pilot's taking direct control of the reaction control system. The analysis described here suggests that, rather than events following the pilot's switch to direct control, it was the events preceding the switch that led to the accident. Consequently, the analyses and conclusions regarding the causal factors of, and the contributing factors to, the loss of Flight 3-65 presented here differ from those of the AIB based on the same evidence. Although the accident occurred in 1967, the results of the presented analysis are still relevant today. We present our analysis and discuss its implications for the safety of space operations.
Data from GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity (2023)

&lt;div&gt;Abstract&lt;p&gt;Maturation of human natural killer (NK) cells as defined by accumulation of cell-surface expression of CD57 is associated with increased cytotoxic character and TNF and IFNγ production upon target-cell recognition. Notably, multiple studies point to a unique role for CD57&lt;sup&gt;+&lt;/sup&gt; NK cells in cancer immunosurveillance, yet there is scant information about how they mature. In this study, we show that pharmacologic inhibition of GSK3 kinase in peripheral blood NK cells expanded &lt;i&gt;ex vivo&lt;/i&gt; with IL15 greatly enhances CD57 upregulation and late-stage maturation. GSK3 inhibition elevated the expression of several transcription factors associated with late-stage NK-cell maturation including T-BET, ZEB2, and BLIMP-1 without affecting viability or proliferation. When exposed to human cancer cells, NK cell expanded &lt;i&gt;ex vivo&lt;/i&gt; in the presence of a GSK3 inhibitor exhibited significantly higher production of TNF and IFNγ, elevated natural cytotoxicity, and increased antibody-dependent cellular cytotoxicity. In an established mouse xenograft model of ovarian cancer, adoptive transfer of NK cells conditioned in the same way also displayed more robust and durable tumor control. Our findings show how GSK3 kinase inhibition can greatly enhance the mature character of NK cells most desired for effective cancer immunotherapy. &lt;i&gt;Cancer Res; 77(20); 5664–75. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Conditions for Circularly Polarized Plane Wave Propagation in a Linear Bianisotropic Medium (2002)

Derived here are four conditions that must be satisfied by the constitutive parameters of a linear, homogeneous, bianisotropic medium for it to support the propagation of a circularly polarized plane wave along a fixed axis.
Isomer‐specific retinoic acid biosynthesis in HeLa cells expressing recombinant class I aldehyde dehydrogenases (2006)

Retinal dehydrogenase type 1 (RALDH1) catalyzes the oxidation of all‐trans and 9‐cis retinal to the respective retinoic acids (RAs), whereas another member of the aldehyde dehydrogenase family, the phenobarbital‐induced aldehyde dehydrogenase (PB‐ALDH), is very poorly active. We have previously generated chimeras between these two enzymes that displayed selectivity for retinal isomers in crude bacterial extracts. Here, we have characterized the kinetic properties of the corresponding purified recombinant proteins, and demonstrate that these chimeras catalyze oxidation of retinal isomers with high efficiency and selectivity. To examine whether the selectivity of the recombinant enzymes is retained in vivo, we first assessed whether retinoid‐isomerizing activity is present in cultured eukaryotic cells. Our results demonstrate that the only RA isomers detected in RALDH1‐expressing or non‐expressing cells corresponded to the same steric conformation as the supplied retinoids, indicating a lack of measurable 9‐cis/all‐trans retinoid‐isomerizing activity. Finally, HeLa cells transfected with RALDH1 derivatives that were retinal isomer‐selective in vitro produced only the corresponding isomers of RA in vivo, establishing these enzymes as useful tools to assess the respective roles of the two RA isomers in vivo. (supported by CIHR grant)
Thermo-mechanical behavior of epoxy shape memory polymer foams (2007)

Shape memory polymer foams have significant potential in biomedical and aerospace applications, but their thermo-mechanical behavior under relevant deformation conditions is not well understood. In this paper we examine the thermo-mechanical behavior of epoxy shape memory polymer foams with an average relative density of nearly 20%. These foams are deformed under conditions of varying stress, strain, and temperature. The glass transition temperature of the foam was measured to be approximately 90 °C and compression and tensile tests were performed at temperatures ranging from 25 to 125 °C. Various shape recovery tests were used to measure recovery properties under different thermo-mechanical conditions. Tensile strain to failure was measured as a function of temperature to probe the maximum recovery limits of the foam in both temperature and strain space. Compression tests were performed to examine compressibility of the material as a function of temperature; these foams can be compacted as much as 80% and still experience full strain recovery over multiple cycles. Furthermore, both tensile strain to failure tests and cyclic compression recovery tests revealed that deforming at a temperature of 80 °C maximizes macroscopic strain recovery. Deformation temperatures above or below this optimal value lead to lower failure strains in tension and the accumulation of non-recoverable strains in cyclic compression. Micro-computed tomography (micro-CT) scans of the foam at various compressed states were used to understand foam deformation mechanisms. The micro-CT studies revealed the bending, buckling, and collapse of cells with increasing compression, consistent with results from published numerical simulations.
Metal Nanoclusters with Synergistically Engineered Optical and Buffering Activity of Intracellular Reactive Oxygen Species by Compositional and Supramolecular Design (2017)

Abstract Metal nanoclusters featuring tunable luminescence and high biocompatibility are receiving attention as fluorescent markers for cellular imaging. The recently discovered ability of gold clusters to scavenge cytotoxic reactive oxygen species (ROS) from the intracellular environment extends their applicability to biomedical theranostics and provides a novel platform for realizing multifunctional luminescent probes with engineered anti-cytotoxic activity for applications in bio-diagnostics and conceivably cellular therapy. This goal could be achieved by using clusters of strongly reactive metals such as silver, provided that strategies are found to enhance their luminescence while simultaneously enabling direct interaction between the metal atoms and the chemical surroundings. In this work, we demonstrate a synergic approach for realizing multifunctional metal clusters combining enhanced luminescence with strong and lasting ROS scavenging activity, based on the fabrication and in situ protection of Ag nanoclusters with a supramolecular mantle of thiolated-Au atoms (Ag/Au-t). Confocal imaging and viability measurements highlight the biocompatibility of Ag/Au-t and their suitability as fluorescent bio-markers. ROS concentration tests reveal the remarkable scavenging activity of Ag-based clusters. Proliferation tests of cells in artificially stressed culture conditions point out their prolonged anti-cytotoxic effect with respect to gold systems, ensuring positive cell proliferation rates even for long incubation time.
Unsupervised Translation Sense Clustering (2012)

We propose an unsupervised method for clus-tering the translations of a word, such that the translations in each cluster share a com-mon semantic sense. Words are assigned to clusters based on their usage distribution in large monolingual and parallel corpora using the softK-Means algorithm. In addition to de-scribing our approach, we formalize the task of translation sense clustering and describe a procedure that leverages WordNet for evalu-ation. By comparing our induced clusters to reference clusters generated from WordNet, we demonstrate that our method effectively identifies sense-based translation clusters and benefits from both monolingual and parallel corpora. Finally, we describe a method for an-notating clusters with usage examples. 1