gebhart/patrepeval huggingface dataset:
Effect of platelet-rich plasma on bone regeneration in ovariectomized osteoporotic rats (2010)

연구 목적: 본 연구의 목적은 실험용 쥐의 초기 골 재생 과정에서 혈소판 농축 혈장 (platelet-rich plasma; PRP)이 난소호르몬 분비 유무에 따라 각각 어떤 효과를 나타내는지 확인 비교해 보는 것이다. 연구 재료 및 방법: 실험용 쥐 40마리 중 20마리에는 난소절제술 (ovariectomy; OVX)을 시행하여 골다공증을 유발시킨 상태에서 골 이식을 하였고, 나머지 20마리에는 난소절제술 없이 골 이식을 하였다. 또, 난소절제술을 시행한 쥐 중 10마리와 난소절제술을 시행하지 않은 쥐 중 10마리에는 골 이식 시 골전도성 합성골 이식재인 $MBCP^{TM}$ (Micro-& macro-porous biphasic calcium phosphate)에 혈소판 농축 혈장을 첨가하여 적용하고, 아래와 같은 실험군으로 구분하였다. A군; 10마리의 non-OVX 쥐/골 이식재 ( $MBCP^{TM}$ ). B군; 10마리의 non-OVX 쥐/골 이식재( $MBCP^{TM}$ )+PRP. C군; 10마리의OVX 쥐/골 이식재( $MBCP^{TM}$ ). D군; 10마리의OVX 쥐/골 이식재( $MBCP^{TM}$ )+PRP. 모든 실험동물의 두 개관 정중부에 직경 8 mm 원형의 임계 크기 결함을 한 개씩 인위적으로 형성한 후, 임계 크기 결함 내부에 골 이식재 및 혈소판 농축 혈장을 적용하여 골 이식술을 실시하였다. 골이식 시행 4주 후에 실험 동물을 희생시켜 표본을 제작한 후, 광학현미경상을 관찰하고 기존에 형성한 임계 크기 결함 내부에 새롭게 침착된 신생골의 면적을 측정하여 그 측정값을 통계 분석하였다. 결과: 신생골 면적 측정값을 각 군 간 비교하여 다음과 같은 결과를 얻었다. 1. 난소절제술이 시행되지 않은 정상 쥐에서는 혈소판 농축 혈장의 사용이 골 재생에 유의한 효과를 나타내지는 않았다 (p>.05). 2. 난소절제술이 시행된 골다공증 유발 쥐에서는 혈소판 농축 혈장의 사용이 골 재생에 유의한 효과를 나타내었다 (P .05). 결론: 이상의 결과를 토대로, 골전도성 합성골 이식재와 함께 쓰인 혈소판 농축 혈장은 정상 쥐에서보다 난소절제술이 시행된 골다공증 유발 쥐에서 골 재생 및 치유에 더 큰 효과가 있음을 알 수 있었다. 【Purpose: The aim of this experimental study is to observe the effect of platelet-rich plasma (PRP) on early bone regeneration of rats both in normal condition and in osteoporosis induced by ovariectomy. Material and methods: Total 40 Sprague-Dawley female rats were divided into 4 groups. A 8-mm-diameter calvarial critical-sized defect (CSD) was made by drilling with trephine at the center of calvaria in cranium of every rat. Every CSD was augmented with an osteoconductive synthetic alloplastic substitute ( $MBCP^{TM}$ ) and PRP as follows. Group A; 10 non-ovariectomized rats grafted with only $MBCP^{TM}$ . Group B; 10 non-ovariectomized rats grafted with $MBCP^{TM}$ and PRP. Group C; 10 ovariectomized rats grafted with only $MBCP^{TM}$ . Group D; 10 ovariectomized rats grafted with $MBCP^{TM}$ and PRP. At 4 weeks after graft, every rat was sacrificed. And histomorphometric analysis was performed by measuring calcified area of new bone formation within the CSD. Results: Comparing four groups, results were obtained as follows. 1. In non-ovariectomized groups, PRP showed a positive effect somewhat but not significant (P > .05). 2. In ovariectomized groups, PRP showed a positive effect significantly (P .05). Conclusion: Within the limitation of this study, it can be concluded that PRP in combination with an osteoconductive synthetic alloplastic substitute has an effect on bone regeneration more significantly in ovariectomized osteoporotic rats than in normal rats.】
Designing Molecules by Optimizing Potentials (2006)

The astronomical number of accessible discrete chemical structures makes rational molecular design extremely challenging. We formulate the design of molecules with specific tailored properties as performing a continuous optimization in the space of electron-nuclear attraction potentials. The optimization is facilitated by using a linear combination of atomic potentials (LCAP), a general framework that creates a continuous property landscape from an otherwise unlinked set of discrete molecular-property values. A demonstration of this approach is given for the optimization of molecular electronic polarizability and hyperpolarizability. We show that the optimal structures can be determined without enumerating and separately evaluating the characteristics of the combinatorial number of possible structures, a process that would be much slower. The LCAP approach may be used with quantum or classical Hamiltonians, suggesting possible applications to drug design and new materials discovery.
ChemInform Abstract: Vinyl Oxocarbenium Ions in Intermolecular (4 + 3) Cycloaddition Reactions. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The HSP90 Inhibitor NVP-AUY922 Potently Inhibits Non–Small Cell Lung Cancer Growth (2013)

Heat shock protein 90 (HSP90) is involved in protein folding and functions as a chaperone for numerous client proteins, many of which are important in non-small cell lung cancer (NSCLC) pathogenesis. We sought to define preclinical effects of the HSP90 inhibitor NVP-AUY922 and identify predictors of response. We assessed in vitro effects of NVP-AUY922 on proliferation and protein expression in NSCLC cell lines. We evaluated gene expression changes induced by NVP-AUY922 exposure. Xenograft models were evaluated for tumor control and biological effects. NVP-AUY922 potently inhibited in vitro growth in all 41 NSCLC cell lines evaluated with IC50 < 100 nmol/L. IC100 (complete inhibition of proliferation) < 40 nmol/L was seen in 36 of 41 lines. Consistent gene expression changes after NVP-AUY922 exposure involved a wide range of cellular functions, including consistently decreased dihydrofolate reductase after exposure. NVP-AUY922 slowed growth of A549 (KRAS-mutant) xenografts and achieved tumor stability and decreased EGF receptor (EGFR) protein expression in H1975 xenografts, a model harboring a sensitizing and a resistance mutation for EGFR-tyrosine kinase inhibitors in the EGFR gene. These data will help inform the evaluation of correlative data from a recently completed phase II NSCLC trial and a planned phase IB trial of NVP-AUY922 in combination with pemetrexed in NSCLCs.
The Minnesota Constitution as a Sword: The Evolving Private Cause of Action (1994)

When is a civil remedy available to a person injured through a violation of the Minnesota Constitution?The answer must be found in a small and often contradictory body of Minnesota case law.To date, the great majority of cases that have involved
Characterizing users&#x2019; visual analytic activity for insight provenance (2008)

Insight provenance - a historical record of the process and rationale by which an insight is derived - is an essential requirement in many visual analytics applications. While work in this area has relied on either manually recorded provenance (e.g., user notes) or automatically recorded event-based insight provenance (e.g., clicks, drags, and key-presses), both approaches have fundamental limitations. Our aim is to develop a new approach that combines the benefits of both approaches while avoiding their deficiencies. Toward this goal, we characterize userspsila visual analytic activity at multiple levels of granularity. Moreover, we identify a critical level of abstraction, Actions, that can be used to represent visual analytic activity with a set of general but semantically meaningful behavior types. In turn, the action types can be used as the semantic building blocks for insight provenance. We present a catalog of common actions identified through observations of several different visual analytic systems. In addition, we define a taxonomy to categorize actions into three major classes based on their semantic intent. The concept of actions has been integrated into our labpsilas prototype visual analytic system, HARVEST, as the basis for its insight provenance capabilities.
Proper Motions with Subaru I. Methods and a First Sample in the Subaru Deep Field (2009)

Abstract We search for stars with proper motions in a set of twenty deep Subaru images, covering about 0.28 square degrees to a depth of $i^\prime$$\simeq$ 25, taken over a span of six years. In this paper, we describe in detail our reduction and techniques to identify moving objects. We present a first sample of 99 stars with motions of high significance, and discuss briefly the populations from which they are likely drawn. Based on photometry and motions alone, we expect that 9 of the candidates may be white dwarfs. We also find a group of stars which may be extremely metal-poor subdwarfs in the halo.
Channel electron conduction in laser-annealed polycrystalline silicon metal-oxide semiconductor field-effect transistors (1981)

A scanned cw Ar+ laser was used to anneal the polycrystalline silicon on nitride structures. Laser power varied from l0 to 15 W in increments of 1 W, the beam diameter was ∼40 μm and the scan rate was ∼12.5 cm/s. The measured field-effect electron mobility of the metal-oxide semiconductor field effect transistor fabricated on the annealed silicon increases with increasing laser power. In transistors annealed at power ⩽11 W, an intercrystalline potential barrier resulting from the electron trapping at crystallite and grain boundary regions was found to be the dominant factor in the channel electron conduction. In transistors annealed at power ⩾ 12 W, channel conduction is limited by scattering from surface structure imperfections.
Pharmacotherapy of PTSD in the U.S. Department of Veterans Affairs (2008)

Diverse psychotropic medication classes are extensively used in the treatment of PTSD in the VA. While disease-specific use for both PTSD and comorbid disorders is common, substantial use seems to be unrelated to diagnosis and thus is likely to be targeted at specific symptoms (e.g., insomnia, anxiety, nightmares, and flashbacks) rather than diagnosed illnesses. A new type of efficacy research may be needed to determine symptom responses to psychotropic medications as well as disorder responses, perhaps across diagnoses.
Efficient Triplet Application in Exciplex Delayed-Fluorescence OLEDs Using a Reverse Intersystem Crossing Mechanism Based on a ΔES–T of around Zero (2014)

We demonstrate highly efficient exciplex delayed-fluorescence organic light-emitting diodes (OLEDs) in which 4,4',4″-tris[3-methylphenyl(phenyl)aminotriphenylamine (m-MTDATA) and 4,7-diphenyl-1,10-phenanthroline (Bphen) were selected as donor and acceptor components, respectively. Our m-MTDATA:Bphen exciplex electroluminescence (EL) mechanism is based on reverse intersystem crossing (RISC) from the triplet to singlet excited states. As a result, an external quantum efficiency (EQE) of 7.79% at 10 mA/cm(2) was observed, which increases by 3.2 and 1.5 times over that reported in Nat. Photonics 2012, 6, 253 and Appl. Phys. Lett. 2012, 101, 023306, respectively. The high EQE would be attributed to a very easy RISC process because the energy difference between the singlet and triplet excited states is almost around zero. The verdict was proven by photoluminescence (PL) rate analysis at different temperatures and time-resolved spectral analysis. Besides, the study of the transient PL process indicates that the presence of an unbalanced charge in exciplex EL devices is responsible for the low EQE and high-efficiency roll-off. When the exciplex devices were placed in a 100 mT magnetic field, the permanently positive magnetoelectroluminescence and magnetoconductivity were observed. The magnetic properties confirm that the efficient exciplex EL only originates from delayed fluorescence via RISC processes but is not related to the triplet-triplet annihilation process.
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination (2023)

The arginine dependency of cancer cells creates metabolic vulnerability. In this study, we examine the impact of arginine availability on DNA replication and genotoxicity resistance. Using DNA combing assays, we find that limiting extracellular arginine results in the arrest of cancer cells at S phase and a slowing or stalling of DNA replication. The translation of new histone H4 is arginine dependent and influences DNA replication. Increased proliferating cell nuclear antigen (PCNA) occupancy and helicase-like transcription factor (HLTF)-catalyzed PCNA K63-linked polyubiquitination protect arginine-starved cells from DNA damage. Arginine-deprived cancer cells display tolerance to genotoxicity in a PCNA K63-linked polyubiquitination-dependent manner. Our findings highlight the crucial role of extracellular arginine in nutrient-regulated DNA replication and provide potential avenues for the development of cancer treatments.
2.4 CENTRAL SYSTOLIC BLOOD PRESSURE PROVIDES ADDITIONAL INFORMATION IN RISK PREDICTION IN HEMODIALYSIS PATIENTS (2018)

Background: Association of Ambulatory Blood Pressure Monitoring (ABPM) with mortality depends on cardiac function in hemodialysis patients. Evidence for the predictive power of central Systolic Pressure (cSBP) is inconclusive. Thus, this study aimed to investigate the additional information of ambulatory cSBP in risk prediction in a cohort of hemodialysis patients. Methods: Within the ISAR-study cohort, 344 hemodialysis patients underwent 24 h ABPM on the dialysis day. All-cause and cardiovascular mortality served as endpoints. Risk prediction was performed using Cox regression in patients with or without atrial fibrillation (AF) or heart failure (HF) for peripheral (pSBP) and central systolic pressure calibrated with peripheral systolic and diastolic pressure (cSBP1) or peripheral mean and diastolic pressure (cSBP2). Results: During a mean follow-up of 37.6 (17.5 SD) months, 115 patients died, of whom 47 due to cardiovascular reasons. In patients with AF or HF, a negative association to mortality could be observed, independent of pressure location and calibration (see Table). In patients without AF or HF, these associations were to the opposite directions and cSBP2 was superior to pSBP and cSBP1 for all-cause (pSBP: HR = 1.01, p = 0.30; cSBP1: HR = 1.00, p = 0.77; cSBP2: HR = 1.01, p = 0.06) and cardiovascular (pSBP: HR =1.03, p = 0.02; cSBP1: HR = 1.02, p = 0.06; cSBP2: HR = 1.03, p = 0.003) mortality. This circumstance was confirmed in multivariable analysis combining pSBP and differences between pSBP and cSBP (see Table). Conclusions: This study provides evidence for the additional information of central systolic blood pressure and its dependency on calibration in risk prediction in hemodialysis patients. Further studies are needed to confirm these findings.
Pneumatic and hydraulic microactuators: a review (2010)

The development of MEMS actuators is rapidly evolving and continuously new progress in terms of efficiency, power and force output is reported. Pneumatic and hydraulic are an interesting class of microactuators that are easily overlooked. Despite the 20 years of research, and hundreds of publications on this topic, these actuators are only popular in microfluidic systems. In other MEMS applications, pneumatic and hydraulic actuators are rare in comparison with electrostatic, thermal or piezo-electric actuators. However, several studies have shown that hydraulic and pneumatic actuators deliver among the highest force and power densities at microscale. It is believed that this asset is particularly important in modern industrial and medical microsystems, and therefore, pneumatic and hydraulic actuators could start playing an increasingly important role. This paper shows an in-depth overview of the developments in this field ranging from the classic inflatable membrane actuators to more complex piston-cylinder and drag-based microdevices. © 2010 IOP Publishing Ltd.
Iterative reconstruction of bandlimited images from nonuniformly spaced samples (1987)

We investigate the reconstruction of band-limited 2-D functions from nonuniformly spaced samples. Three algorithms which iterate between the space and frequency domains are developed. The algorithms differ in the manner in which the known value of the function at sample points is used to correct the reconstruction at each iteration. Convergence of the algorithms is speeded by choosing the largest possible gain for the error correction. The performance of the three methods is compared to that of thin-plate spline interpolation in terms of signal to error energy ratio.
Wirtschaftlichkeitsbetrachtung von Krankenhäusern: Von der Schwierigkeit, Defizite aufzuspüren (2017)

Die vergangenen Gesundheitsreformen zielten vorrangig darauf ab, die wachsenden Gesundheitsausgaben einzudämmen – der Wirtschaftlichkeitsdruck im Krankenhausmarkt ist somit gestiegen. Gleichzeitig wird eine qualitativ hochwertige Patientenversorgung immer wichtiger. In diesem Spannungsverhältnis zwischen Qualität und Wirtschaftlichkeit entstehen in einzelnen Krankenhäusern immer häufiger wirtschaftliche Defizite. Doch wie kann man dem entgegenwirken?
Chemically-bonded aminosilane stationary phase for the high-performance liquid chromatographic separation of polynuclear aromatic compounds (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemically-bonded aminosilane stationary phase for the high-performance liquid chromatographic separation of polynuclear aromatic compoundsS. A. Wise, S. N. Chesler, H. S. Hertz, L. R. Hilpert, and W. E. MayCite this: Anal. Chem. 1977, 49, 14, 2306–2310Publication Date (Print):December 1, 1977Publication History Published online1 May 2002Published inissue 1 December 1977https://pubs.acs.org/doi/10.1021/ac50022a049https://doi.org/10.1021/ac50022a049research-articleACS PublicationsRequest reuse permissionsArticle Views544Altmetric-Citations189LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bleeding-Related Complications and Readmission Rates Associated With Fibrin Sealant Use in Patients Undergoing Coronary Artery Bypass Graft Surgery in the United States (2016)

Results from this real-world retrospective database analysis showed fewer bleeding complications and lower costs in patients undergoing primary CABG surgery who received EVICEL compared with TISSEEL.
Contribution of a central proline in model amphipathic α‐helical peptides to self‐association, interaction with phospholipids, and antimicrobial mode of action (2006)

Model amphipathic peptides have been widely used as a tool to determine the structural and biological properties that control the interaction of peptides with membranes. Here, we have focused on the role of a central Pro in membrane-active peptides. To determine the role of Pro in structure, antibiotic activity, and interaction with phospholipids, we generated a series of model amphipathic alpha-helical peptides with different chain lengths and containing or lacking a single central Pro. CD studies showed that Pro-free peptides (PFPs) formed stable alpha-helical structures even in aqueous buffer through self-association, whereas Pro-containing peptides (PCPs) had random coil structures. In contrast, in trifluoroethanol or SDS micelles, both PFPs and PCPs adopted highly ordered alpha-helical structures, although relatively lower helical contents were observed for the PCPs than the PFPs. This structural consequence indicates that a central Pro residue limits the formation of highly helical aggregates in aqueous buffer and causes a partial distortion of the stable alpha-helix in membrane-mimetic environments. With regard to antibiotic activity, PCPs had a 2-8-fold higher antibacterial activity and significantly reduced hemolytic activity compared with PFPs. In membrane depolarization assays, PCPs passed rapidly across the peptidoglycan layer and immediately dissipated the membrane potential in Staphylococcus aureus, whereas PFPs had a greatly reduced ability. Fluorescence studies indicated that, although PFPs had strong binding affinity for both zwitterionic and anionic liposomes, PCPs interacted weakly with zwitterionic liposomes and strongly with anionic liposomes. The selective membrane interaction of PCPs with negatively charged phospholipids may explain their antibacterial selectivity. The difference in mode of action between PCPs and PFPs was further supported by kinetic analysis of surface plasmon resonance data. The possible role of the increased local backbone distortion or flexibility introduced by the proline residue in the antimicrobial mode of action is discussed.
Enzymatic modification of jute fabrics for enhancing the reinforcement in jute/PP composites (2017)

In this work, laccase was employed to improve the properties of lignocellulosic jute fabrics and then the modified jute was used as the fiber reinforcement of polypropylene (PP) matrix composites to improve its reinforcing effect on the polymer resins and obtain composite materials with better performance. The decrease in the –C–O–H component and the increase in the –C–O–C component on the surface of laccase-treated jute fabrics suggested that phenolic hydroxyl groups of lignins on the jute fiber surface were oxidized by laccase and the produced phenoxyl radicals were coupled to form ether structures. The laccase-treated jute fiber surface became smooth with lignins attached tightly. Moreover, the surface hydrophobicity and tensile properties of the jute fabrics were increased via the laccase-mediated reactions of lignins. PP composites reinforced by the laccase-treated jute fabrics showed higher breaking strength, storage modulus, and melting temperature than the control. The fracture surface of the laccase-treated jute fabric/PP composites was neat and jute fibers on the section surface were surrounded by PP resins closely, which indicated better interfacial adhesion between the modified jute reinforcement and PP matrix.
Biochemical Analysis of MST1 Kinase: Elucidation of a C-Terminal Regulatory Region (2008)

The MST1 kinase phosphorylates FoxO transcription factors in the cytosol and histone H2B in the nucleus to promote cellular apoptosis. In addition to a N-terminal kinase domain, MST1 contains C-terminal regulatory and dimerization regions that are cleaved upon nuclear transport. In this report, we investigate the role of the MST1 regulatory region and dimerization domain in MST1 activity toward FoxO and histone H2B substrates. We find that the MST1 regulatory region enhances FoxO phosphorylation while inhibiting histone H2B phosphorylation, consistent with the cellular properties of MST1. We also identify autophosphorylation sites within the MST1 regulatory region and show that both regulatory region phosphorylation and MST1 dimerization contribute to FoxO phosphorylation. Together, our studies provide new insights into how MST1 substrate selectivity is modulated with implications for understanding apoptotic signaling through MST1 kinase.
Hydraulic Losses and Flow Patterns on the Swirling Flow in U Bends (1980)

実用の管路系に用いられる曲り管には,不均一流や強い旋回成分を伴った流れが流入する場合が多いにもかかわらず,これまでこのような場合の水力損失や流動状態はあまり研究されていない.本研究では,U字管の曲率半径および壁面あらさを種々変化させて,U字管に旋回流が流入した場合の水力損失と内部の流れ形状の関係を調べた.
Preparation of (Z)-1-Halo-1-alkenes and (Z)-1-Halo-2-alkoxy-1-alkenes Using Cr(II/III) and Fe(0) (2006)

Reduction of 1,1,1-trihaloalkanes by Cr(II) or Cr(III) regenerated by Fe(0) in moist tetrahydrofuran at room temperature stereoselectively generates (Z)-1-halo-1-alkenes and (Z)-1-halo-2-alkoxy-1-alkenes in good to excellent yields.