gebhart/patrepeval huggingface dataset:
Phenazines, phenoxazinones, and dioxopiperazines from Streptomyces thioluteus (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhenazines, phenoxazinones, and dioxopiperazines from Streptomyces thioluteusNancy N. GerberCite this: J. Org. Chem. 1967, 32, 12, 4055–4057Publication Date (Print):December 1, 1967Publication History Published online1 May 2002Published inissue 1 December 1967https://pubs.acs.org/doi/10.1021/jo01287a075https://doi.org/10.1021/jo01287a075research-articleACS PublicationsRequest reuse permissionsArticle Views232Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neuronal Cell Cycle Re-Entry Markers are Altered in the Senescence Accelerated Mouse P8 (SAMP8) (2012)

Senescence-accelerated mice 8 (SAMP8), a model of aging, display many established pathological features of Alzheimer's disease (AD); however, whether cell cycle alterations exist in these animals remains unknown. Given that these animals present changes such as tau phosphorylation and redox imbalance, both associated with cell cycle alterations, we determined whether changes in cell cycle markers were present in SAMP8 and SAMR1 (control strain) at 3, 6, and 9 months-old brains. As expected, an increase in tau hyperphosphorylation and its associated machinery, i.e., cdk5 and GSK3β, was observed both between strains and also with aging. Particularly, significant differences in cyclin A, cyclin D1, cyclin E, Cdk2, cyclin B, pR, and E2F1 were found when comparing SAMP8 to SAMR1. More interestingly, a partial correlation with several cell cycle markers described in AD brain is found in SAMP8, indicating that some specific hallmarks of AD are also present in this strain, which has been postulated as an early switch model of the disease.
Changes in Osteogenic Activity of MG63 Cells on Hydroxyapatite/Collagen Nanocomposite Sponge under Pressure/Perfusion Culture (2007)

The bone-like self-organized hydroxyapatite/collagen (HAp/Col) nanocomposite sponge was prepared from HAp/Col nanocomposite fibers. We analyzed osteogenic activity of human osteoblastic MG63 cells in the HAp/Col sponge under pressure/perfusion culture. Collagen (Col) sponge was used as a control. The MG63 cells were attached well and showed good proliferation in the HAp/Col sponge. The total DNA content in the HAp/Col sponge was approximately 1.8 times greater than that in the Col sponge at 21 days. The MG63 cells showed good osteogenic gene expression in the HAp/Col sponge by reverse transcription-polymerase chain reaction analysis. These result suggested that HAp/Col sponge can be useful for bone tissue engineering scaffold materials.
Relayed nuclear Overhauser enhancement sensitivity to membrane Cho phospholipids (2020)

We demonstrated specific relayed nuclear Overhauser effects in partially restricted phospholipid phantoms and similar effects in solid brain tumors after correcting for confounding signal contributions, suggesting possible translational applications of this novel molecular imaging method, which we name restricted phospholipid transfer.
Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. (1993)

The products of the HIR1 and HIR2 genes have been defined genetically as repressors of histone gene transcription in S. cerevisiae. A mutation in either gene affects cell cycle regulation of three of the four histone gene loci; transcription of these loci occurs throughout the cell cycle and is no longer repressed in response to the inhibition of DNA replication. The same mutations also eliminate autogenous regulation of the HTA1-HTB1 locus by histones H2A and H2B. The HIR1 and HIR2 genes have been isolated, and their roles in the transcriptional regulation of the HTA1-HTB1 locus have been characterized. Neither gene encodes an essential protein, and null alleles derepress HTA1-HTB1 transcription. Both HIR genes are expressed constitutively under conditions that lead to repression or derepression of the HTA1 gene, and neither gene regulates the expression of the other. The sequence of the HIR1 gene predicts an 88-kDa protein with three repeats of a motif found in the G beta subunit of retinal transducin and in a yeast transcriptional repressor, Tup1. The sequence of the HIR2 gene predicts a protein of 98 kDa. Both gene products contain nuclear targeting signals, and the Hir2 protein is localized in the nucleus.
Advances in the Treatment of Erectile Dysfunction (2006)

Progress in the clinical management of erectile disorders, and specifically erectile dysfunction (ED), has gained substantially from basic science advances in the field. Unquestionably, the advance of phosphodiesterase 5 (PDE5) inhibitor therapy quickly followed the basic scientific description of nitric oxide (NO) signaling in erectile tissue. Further investigation of the neurotransmission involved in penile erection, hormone actions involved in this response, and biochemical signal transduction processes within the erectile tissue represent major areas of scientific pursuit. Current objectives scientifically are to identify and characterize molecular targets operating at multiple levels of the nervous system, endocrine system, and vascular system all related to penile erection. It is conceivable that new knowledge involving these systems may be exploited to develop various therapeutic approaches to manage ED. These approaches include pharmacotherapy, growth factor interventions, cell and tissue engineering, and gene therapy.
Printed MWCNT-PDMS-Composite Pressure Sensor System for Plantar Pressure Monitoring in Ulcer Prevention (2015)

In this paper, a low cost and flexible plantar pressure monitoring system is presented that is suited for everyday use to prevent pressure ulcers. To define the technical specifications of the sensor system, a gait analysis study was carried out. Analysis of measured data based on a multivariate approach and neural network classification shows that it is possible to dissociate between healthy and unhealthy rollover patterns. To implement a pressure sensor element, a multiwalled carbon nanotube (MWCNT)-polydimethylsiloxane (PDMS)-composite was selected. A sensor matrix made of the composite was fully printed to enable pressure distribution measurements. As a final application, a printed insole was fabricated with six single MWCNT-PDMS pressure sensors that were situated on characteristic points of the insole to detect the unhealthy rollover patterns. Its functionality to measure plantar pressures was proven on a human foot inside a running shoe during walking.
Analysis of hohlraum energetics of the SG series and the NIF experiments with energy balance model (2016)

The basic energy balance model is applied to analyze the hohlraum energetics data from the Shenguang (SG) series laser facilities and the National Ignition Facility (NIF) experiments published in the past few years. The analysis shows that the overall hohlraum energetics data are in agreement with the energy balance model within 20% deviation. The 20% deviation might be caused by the diversity in hohlraum parameters, such as material, laser pulse, gas filling density, etc. In addition, the NIF's ignition target designs and our ignition target designs given by simulations are also in accordance with the energy balance model. This work confirms the value of the energy balance model for ignition target design and experimental data assessment, and demonstrates that the NIF energy is enough to achieve ignition if a 1D spherical radiation drive could be created, meanwhile both the laser plasma instabilities and hydrodynamic instabilities could be suppressed.
Synthesis and characterization of N-acyl-tetra-O-acyl glucosamine derivatives (2013)

Novel 1,3,4,6-tetra-O-acyl-N-acyl-D-glucosamine derivatives were synthesized from glucosamine hydrochloride (GlcN·HCl) by the acylation with pyridine as a catalyst. A derivative of tetra-O-acetyl glucosamine contained ketoprofen, a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects, was first synthesized. In analysis of the NMR spectra, the ratio of α:β-anomer showed that penta-acyl-D-glucosamine derivatives and N-acetylated glucosamines containing O-acyl groups have been only the α-anomer. Meanwhile, both the intermediates and the glucoconjugate compound of ketoprofen have only the β-anomer.
A CMOS compatible thermoelectric device made of crystalline silicon membranes with nanopores (2022)

Herein, we report the use of nanostructured crystalline silicon as a thermoelectric material and its integration into thermoelectric devices. The proof-of-concept relies on the partial suppression of lattice thermal conduction by introducing pores with dimensions scaling between the electron mean free path and the phonon mean free path. In other words, we artificially aimed at the well-known 'electron crystal and phonon glass' trade-off targeted in thermoelectricity. The devices were fabricated using CMOS-compatible processes and exhibited power generation up to 5.5 mW cm<sup>-2</sup>under a temperature difference of 280 K. These numbers demonstrate the capability to power autonomous devices with environmental heat sources using silicon chips of centimeter square dimensions. We also report the possibility of using the developed devices for integrated thermoelectric cooling.
Vaccination Rates among Younger Siblings of Children with Autism (2017)

The vaccination rate was significantly lower among younger siblings of 206 children with autism spectrum disorder in California than among controls. Parents of children with this disorder reported adverse reactions to vaccination in older children and younger siblings.
Feasibility study of splitting pitch technology on 45nm contact patterning with 0.93 NA (2007)

As semiconductor process technology moves to smaller generations (65nm and beyond), the contact pattern printing becomes the most difficult challenge in the lithography field. The reason comes from the smaller feature size and pitch of contact/via pattern printing that is similar to 2D (two-dimensional) patterning. Contact and via patterns need better image contrast than line/space patterns in pattern printing. Hence, contact/via printing needs a higher k1 value than others. In 65nm generation experience, the k1 is ~0.44 on a 0.85 NA exposure tool. A larger NA exposure tool is expensive and developed slower than the motivation of generation. Hence, the process is difficult to achieve by obtaining larger NA exposure tools. The k1 requirement of 45nm (logic) contact pattering (minimum pitch: 140nm) is ~0.34 on a 0.93 NA exposure tool that is available currently. RET (resolution enhancement technology) is necessary to achieve the difficult process goal. Splitting pitch technology is an RET approach to solving 45nm contact pattering. In this paper, we use a 2P1E (2 photo exposure and 1 etching) approach to meet our process requirements. The original layout is split into dense pitch pattern and semi-iso to iso pattern parts by software. Utilizing strong OAI (off-axis-illumination) on dense pattern part and weak OAI on semi-iso to iso pattern part can obtain better process results.
Correction for Capell et al., A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model (2009)

Understanding the biological basis of social anxiety disorder (SAD), one of the most disabling of the anxiety disorders, will allow for novel treatment strategies to be developed. Here, we show that gut microbiota may be such a target. Mice ...Social anxiety disorder (SAD) is a crippling psychiatric disorder characterized by intense fear or anxiety in social situations and their avoidance. However, the underlying biology of SAD is unclear and better treatments are needed. Recently, the gut ...
Synthesis and Characterization of Gold Nanoparticle/Boron Nitride Nanotube Composites Toward Hydrogen Generation Reaction (2017)

Hydrogen gas is praised for being an environmentally friendly and renewable alternative fuel; however, it is still energy-intensive to produce and is limited in storage due to its gaseous phase. The use of hydrogen feedstock materials (HFMs) is an attempt to address the storage problems of this fuel in which the hydrogen gas is released as needed and stored in HFMs when not being consumed. Many of these materials do not produce hydrogen at a relevant rate for energy applications without the use of a proper catalysts. Gold nanoparticles have displayed impressive catalytic activity for hydrogenation reactions and hydrogen generation reactions. AuMWCNT composites have shown a synergistic relationship where by composites outperform both individual components in these reactions. The recent growth in the field of research of Boron nitride nanotubes (BNNTs) has encouraged many studies of this material, including its capabilities within nanocomposites. BNNTs have demonstrated excellent stability, but are electrically insulating materials. This indicates that the BNNTs will act much differently as a support material for Au nanoparticles as the electrical conductivity of MWCNTs provides stabilization of functionalized materials. The goal of this study is to synthesize and characterize an Au nanoparticle BNNT composite. The synthesis will mimic the technique used in previous works [1]. The produced composites will be characterized via SEM, TEM, and EDS. The materials will also be tested for catalytic activity using a previously described gravimetric water displacement system [1, 2]. References C. Huff, T. Dushatinski, A. Barzanji, N. Abdel-Fattah, K. Barzanji, and T. Abdel-Fattah, ECS J Solid State, 6, M69-M71 (2017). T. Dushatinski, C. Huff, and T. Abdel-Fattah, Applied Surface Science, 385, 282 (2016).
Epidermolysis Bullosa Associated with Laryngeal Stenosis (1978)

A boy with epidermolysis bullosa developed progressive laryngeal obstruction after age six months, with tracheotomy necessary at age three years. By eight years, the larynx was completely occluded by web and scar. Stenosis recurred repeatedly over the next seven years, three to six months after each corrective procedure, but laryngeal patency has been better-maintained since age 15. Laryngeal stenosis, presumably secondary to epithelial detachment, although a rare complication of epidermolysis bullosa, can be serious and life-threatening.
The Tale of Early Hematopoietic Cell Seeding in the Bone Marrow Niche (2006)

Since introduction of the notion of a "niche" that hosts engraftment and activity of hematopoietic cells, there is a massive effort to discover its structure and decipher its function. Our understanding of the niche is continuously changing with reinterpretation of traditional concepts and apprehension of new insights into the biology of hematopoietic cell homing, seeding, and engraftment. Here we discuss some of the early events in hematopoietic stem cell seeding and engraftment and propose a perspective based on visualization of labeled bone marrow cells in real time in vivo. Primary seeding of hematopoietic cells in the bone marrow niches evolves as a complex and dynamic process; however, it follows discrete topological and chronological patterns. Initial seeding occurs on the endosteal surface of the marrow, which includes heterogeneous niches for primary seeding. Several days after transplantation the endosteal niches become more restrictive, hosting primarily mitotically quiescent cells, and gradual centripetal migration is accompanied by engagement in proliferation and differentiation. The hematopoietic niches evolve as heterogeneous three-dimensional microenvironments that are continuously changing over time.
Possible Radical Scavenging Properties of Cicletanine and Renal Protection in Dahl Salt Sensitive Rats (1993)

Much interest in cicletanine, a novel antihypertensive drug, has grown because it uniquely stimulates prostacyclin (PGI2) production and may, thereby, provide further cardiovascular protection. We postulated that cicletanine may be an antioxidant, and assessed its ability to protect the kidney in Dahl salt-sensitive (Dahl S) rats on a high salt diet. Cicletanine eradicated in vitro a stable radical, DPPH, and decreased the lipid peroxidation both in rat brain homogenate and in a xanthine-xanthine oxidase (X-XOD) superoxide generating system. Furthermore, cicletanine attenuated the inhibition of PGI2 synthase activity by 15HPETE. However, cicletanine did not exhibit superoxide dismutase-like activity in X-XOD system, suggesting that it behaves primarily as a hydroxy radical scavenger. A 6 week cicletanine treatment reduced blood pressure in Dahl S rats fed a high salt diet, and ameliorated functional and morphological injury to the kidney. This attenuation of glomerular sclerosis correlated with the attenuation of lipid peroxidation in the kidney homogenate. These data indicate that cicletanine is an antioxidant that protects the kidney from salt-induced hypertension in Dahl salt-sensitive strain rats.
Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins (2017)

Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No. 4324 from the 28S rRNA and its ribose in rat ribosomes (or the equivalent adenine in sensitive ribosomes from other organisms). This adenine is located in the α-sarcin-ricin loop (SRL) that is crucial for anchoring the elongation factor (EF) G and EF2 on the ribosome during mRNA-tRNA translocation in prokaryotes and eukaryotes, respectively. RIPs have been isolated mainly from plants and examples of these proteins are ricin or Pokeweed Antiviral Protein (PAP). These proteins, either alone or as a part of immunotoxins, are useful tools for cancer therapy. The following protocol describes a method to detect the RNA fragment released when the RIP-treated apurinic RNA from rabbit reticulocyte lysate is incubated in the presence of acid aniline by electrophoresis on polyacrylamide gels. The fragment released (Endo's fragment) is diagnostic of the action of RIPs.
CO2 laser blepharoplasty: A comparison to cold steel and electrocautery (1988)

Thirteen patients underwent blepharoplasty in a paired comparison study. A carbon dioxide laser was employed for one side while standard cold steel surgery and electrocautery was used on the contralateral side. In addition to reduced intraoperative time and bleeding, we found less postoperative ecchymosis and edema on the laser-treated side. Long-term follow-up showed no difference between the two sides when cosmetic end result and scars were compared.
A MASTER PLAN UPDATE FOR MARSHFIELD, MASSACHUSETT'S 1986 (1986)

This Master Plan is an update of planning related information for the Marshfield Planning Board. The first stage of any planning study is the gathering of background information and data on which proposals are based. Throughout the past year, information was collected and anaylzed concerning the following: population, employment, natural features, land use, vacant land, schools, recreation, water and sewer systems, traffic circulation, administrative services and the town's fiscal status. This information was collected in order to assist the Town and its citizens in their decisions regarding the future growth of Marshfield. The purpose of this Master Plan is to establish an updated guide for the continuing development of Marshfield. Thus this document is for everyone in Marshfield who is concerned with their community and its future. Marshfield is again at a crossroads, as the Town is facing difficult decisions concerning its future character. A debate has been going on over the last few years between those who advocate preservation of the Town's rural character and those who favor growth to strengthen the Town ' s economic base. In addition the need to create more housing opportunities has become apparent to the Town's officials. Marshfield has a housing affordability problem and under the present federal administration, economic factors will dictate that the Town has to work on solutions with little help. One of the methods which Marshfield itself can employ at little cost is changing portions of the Town ' s Zoning By-Laws. However, this is only a single facet to the problem, which requires a multi-faceted approach. This document promotes a balanced growth approach to the Town ' s future. Such an approach would provide the Town with the means to accommodate growth and development, while providing for the preservation of the Town ' s natural environment. The benefits of such an approach are many; it will provide the Town's officials a rational framework on which to base their decisions regarding development as opposed to a case-by-case response to each development proposal. Developers would be given a clear indication of public policy on how the development should proceed, enabling the developer to save time and money. Thus local growth can occur in a rational and orderly fashion thereby minimizing the fiscal impacts sometimes associated with poorly planned developments. The Town and its various departments, boards and citizens groups must work together and forge a common approach to Marshfield's future
Magnetic AC loss in twisted-filament Bi-2223 tapes (1999)

In AC power-engineering applications, the energy dissipation in the superconductor is dominated by the magnetization due to alternating fields. To reduce this type of loss, conductors are being developed with twisted filaments and an increased matrix resistivity. The magnetic AC loss has been well described for low-T/sub c/ (wire) conductors. In Bi-2223 tapes the picture is different due to strong anisotropy, granularity, flux creep and large aspect ratio of the tape. The magnetic AC loss is investigated at power frequencies in various Bi-2223 tapes (twisted and nontwisted) and with different materials for the matrix (Ag, Ag alloys and ceramic barriers). When the field is parallel to the tape plane, the filaments in twisted tapes can be decoupled and the AC loss is decreased even when the matrix is silver. In tapes with ceramic barriers between the filaments, first indications of filament decoupling are observed also in perpendicular field. Compared to a round wire, there are essential differences between the AC loss mechanisms occurring in a long twisted tape and those in a short piece of nontwisted tape.