gebhart/patrepeval huggingface dataset:
Effect of sunitinib (SU) administration on post-treatment survival in patients with metastatic renal cell carcinoma (mRCC) treated on the upfront randomized phase III trial of sunitinib or interferon alfa (IFN). (2011)

4634 Background: Drugs targeting VEGFR are approved for, or under investigation in, cancer treatment. Animal experiments suggest such therapies may accelerate metastases (Ebos et al, Cancer Cell. 2009). We sought to address whether treatment with a VEGFR agent might accelerate tumor growth after its discontinuation. Methods: We compared the time on treatment (TOT), post-treatment survival (PTS), overall survival (OS), and tumor growth rate constants (g) of patients (pts) with mRCC randomized to either SU or IFN. We used linear regression models to evaluate associations between these measures. Results: Although reported response rate and progression free survival were better in the SU arm [Motzer et al., NEJM 2006], pts randomized to IFN had a longer PTS than pts randomized to SU (medians: 29.1 v 18.7 wks, p=.006). While acquisition of a growth-retarding immune response following IFN cannot be excluded, ≈ 60% of IFN pts eventually received SU or another VEGFR agent and this may have caused the longer PTS following IFN. That randomization to SU was not detrimental is supported by the observation that longer TOT did not reduce PTS (slope of regression line =-0.054, 95%CI -0.189,0.048) indicating increased SU exposure does not adversely impact PTS. Furthermore, tumor response defined as minimum sum of the longest diameters (LD) divided by initial sum of LD, and thus analyzed as a continuous variable, modestly correlated with TOT (Rsq=0.28, p < 0.001), but not at all with PTS (Rsq= 0.027, p=0.02). Similarly, the g calculated while pts received on-study treatment was correlated with TOT (Rsq=0. 68; p<0.0001) and OS (Rsq = 0.40; p<0.0001) but not PTS (Rsq=.008; p=.27). Conclusions: Neither the duration of SU treatment nor its anti-tumor activity, reflected in tumor response and g, had an effect on PTS. Thus, SU reduces tumor growth while administered, improves OS, and appears unlikely to alter tumor biology after treatment discontinuation. Concerns arising from animal models do not appear to apply to pts receiving SU.
A Novel [5+2] Cycloaddition Reaction Using a Dicobalt Acetylene Complex (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Novel [5+2] Cycloaddition Reaction Using a Dicobalt Acetylene ComplexKeiji Tanino, Tadashi Shimizu, Motoki Miyama, and Isao KuwajimaView Author Information Division of Chemistry, Graduate School of Science Hokkaido University, Sapporo 060-0810, Japan Department of Chemistry Tokyo Institute of Technology Meguro, Tokyo 152-8551, Japan Laboratory for Natural Products Chemistry Kitasato University, S-105 1-15-1 Kitasato, Sagamihara 228-8555, Japan Cite this: J. Am. Chem. Soc. 2000, 122, 25, 6116–6117Publication Date (Web):June 8, 2000Publication History Received21 March 2000Published online8 June 2000Published inissue 1 June 2000https://pubs.acs.org/doi/10.1021/ja001003ehttps://doi.org/10.1021/ja001003erapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1187Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Addition reactions,Cations,Cyclization,Ethers,Hydrocarbons Get e-Alerts
Lignans and tocopherols in Indian sesame cultivars (2004)

Abstract Lignan (sesamol, sesamin, and sesamolin) profile was determined in different cultivars (botanically identified or market samples) of sesame seeds and commercial oils procured from different parts of India. The wide variation observed in total lignans from 21 sesame seed and 9 commercial oils was attributed to variations in sesamin and sesamolin contents. Lignan content was high (18 g sesamin/kg, 10 g sesamolin/kg) in seasame cultivars obtained from the northeastern states of India. In two of the commercial oils having the Agmark label, the total lignan content was ∼12 g/kg (7.3 g sesamin, 4.7 g sesamolin), 50% of the maximum permissible levels of unsaponifiable matter. In both the seeds and commercial oils, γ‐tocopherol was the only representative of tocopherol isomers identified. Sesamin and sesamolin were isolated and crystallized from high‐lignan cultivars, and their purity was confirmed by HPLC and spectral (UV and fluorescence) analysis.
Synthesis of Titanium Oxide Nanostructures in Ionic Liquids (2017)

In recent years, the usage of ionic liquids (ILs) in the synthesis of metal oxides has been extensively studied, especially with respect to their possible advantageous effects in comparison to conventional syntheses protocols. Herein, an overview is given on the variety of different syntheses of TiO 2 ‐based materials, which correlates to the diversity of different ionic liquids. Special emphasis is put on the historic development of the IL‐based synthesis of TiO 2 materials in the general context of research on IL‐based materials synthesis. Also, the assumed advantages of both, the synthesis and the resulting TiO 2 materials, are critically revised. It can be concluded that the application of ILs exerts a direct influence on several parameters, namely the phase composition, the dopants or the nanostructuring of the material. Importantly, the research on TiO 2 ‐based materials enables fundamental insights into IL‐specific effects in the synthesis of inorganic materials in general.
Research and development on cognitive radio/dynamic spectrum access technologies (2008)

This paper summarizes needs, deployment scenarios, and fundamental system architecture with regard to cognitive radio/dynamic spectrum access (CR/DSA) technologies on the basis of latest Japanese frequency allocation environment. To realize the technology, National Institute of Information and Communications Technology (NICT) and a Japanese operator and some manufacturers have a project supported by Ministry of Internal Affairs and Communications (MIC) to research and develop enabling technologies on the CR/DSA equipments. This paper also summarizes the results. (6 pages)
PROPAGATION OF HIGH INTENSITY SOUND WAVES (1967)

Abstract : Sound field characteristics were studied as a function of increasing intensity. It was determined that one effect outweighs others. This is the distortion generated within the siren which makes it impossible to generate pure tones above a certain intensity. At high intensity the waveform of the sound assumes a sawtooth shape producing periodic shock waves. Conversely, it is concluded that if the distortion is small at the mouth of the siren, additional distortion in the subsequent propagation will not be significant. Waveforms observed in the AFFDL facility are included in an appendix. Interaction of sound waves from different sirens will, in addition, give rise to intermodulation effects producing sum and difference frequencies. In general, the intensity in the region in which the radiation from different sirens can interact will be so much lower than the intensity in the throat of the siren horn that these effects will also be small compared with harmonic distortion generated in the sirens.
slr2103, a homolog of type-2 diacylglycerol acyltransferase genes, for plastoquinone-related neutral lipid synthesis and NaCl-stress acclimatization in a cyanobacterium, Synechocystis sp. PCC 6803 (2023)

A cyanobacterium, <i>Synechocystis</i> sp. PCC 6803, contains a lipid with triacylglycerol-like TLC mobility but its identity and physiological roles remain unknown. Here, on ESI-positive LC-MS<sup>2</sup> analysis, it is shown that the triacylglycerol-like lipid (lipid X) is related to plastoquinone and can be grouped into two subclasses, X<sub>a</sub> and X<sub>b</sub>, the latter of which is esterified by 16:0 and 18:0. This study further shows that a <i>Synechocystis</i> homolog of type-2 diacylglycerol acyltransferase genes, <i>slr2103</i>, is essential for lipid X synthesis: lipid X disappears in a <i>Synechocystis slr2103</i>-disruptant whereas it appears in an <i>slr2103</i>-overexpressing transformant (OE) of <i>Synechococcus elongatus</i> PCC 7942 that intrinsically lacks lipid X. The <i>slr2103</i> disruption causes <i>Synechocystis</i> cells to accumulate plastoquinone-C at an abnormally high level whereas <i>slr2103</i> overexpression in <i>Synechococcus</i> causes the cells to almost completely lose it. It is thus deduced that <i>slr2103</i> encodes a novel acyltransferase that esterifies 16:0 or 18:0 with plastoquinone-C for the synthesis of lipid X<sub>b</sub>. Characterization of the <i>slr2103</i>-disruptant in <i>Synechocystis</i> shows that <i>slr2103</i> contributes to sedimented-cell growth in a static culture, and to bloom-like structure formation and its expansion by promoting cell aggregation and floatation upon imposition of saline stress (0.3-0.6 M NaCl). These observations provide a basis for elucidation of the molecular mechanism of a novel cyanobacterial strategy to acclimatize to saline stress, and one for development of a system of seawater-utilization and economical harvesting of cyanobacterial cells with high-value added compounds, or blooming control of toxic cyanobacteria.
Functionalized Cellulose: PET Polymer Fibers with Zeolites for Detoxification Against Nerve Agents (2011)

10.3724/SP.J.1077.2011.11558
Boosting Lying Posture Classification with Transfer Learning (2022)

Automatic lying posture tracking is an important factor in human health monitoring. The increasing popularity of the wrist-based trackers provides the means for unobtrusive, affordable, and long-term monitoring with minimized privacy concerns for the end-users and promising results in detecting the type of physical activity, step counting, and sleep quality assessment. However, there is limited research on development of accurate and efficient lying posture tracking models using wrist-based sensor. Our experiments demonstrate a major drop in the accuracy of the lying posture tracking using wrist-based accelerometer sensor due to the unpredictable noise from arbitrary wrist movements and rotations while sleeping. In this paper, we develop a deep transfer learning method that improves performance of lying posture tracking using noisy data from wrist sensor by transferring the knowledge from an initial setting which contains both clean and noisy data. The proposed solution develops an optimal mapping model from the noisy data to the clean data in the initial setting using LSTM sequence regression, and reconstruct clean synthesized data in another setting where no noisy sensor data is available. This increases the lying posture tracking F1-Score by 24.9% for 'left-wrist' and by 18.1% for 'right-wrist' sensors comparing to the case without mapping.
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112 (2009)

Chemical modifications of nociceptin/orphanin FQ (N/OFQ) peptide that result in increased potency and resistance to degradation have recently lead to the discovery of [(pF)Phe(4)Aib(7)Arg(14)Lys(15)]N/OFQ-NH(2) (UFP-112), a novel N/OFQ peptide (NOP) receptor agonist. The aim of this study was to investigate the pharmacological profile of intrathecally administered UFP-112 in monkeys under different behavioral assays. Intrathecal UFP-112 (1-10 nmol) dose-dependently produced antinociception against an acute noxious stimulus (50 degrees C water) and capsaicin-induced thermal hyperalgesia. Intrathecal UFP-112-induced antinociception could be reversed by a NOP receptor antagonist, J-113397 (0.1mg/kg), but not by a classic opioid receptor antagonist, naltrexone (0.03 mg/kg). Like intrathecal morphine, UFP-112 produced antinociception in two primate pain models with a similar magnitude of effectiveness and a similar duration of action that last for 4-5h. Unlike intrathecal morphine, UFP-112 did not produce itch/scratching responses. In addition, intrathecal inactive doses of UFP-112 and morphine produced significant antinociceptive effects when given in combination without increasing scratching responses. These results demonstrated that intrathecal UFP-112 produced long-lasting morphine-comparable antinociceptive effects without potential itch side effect. This study is the first to provide functional evidence that selective NOP receptor agonists such as UFP-112 alone or in conjunction with morphine may improve the quality of spinal analgesia.
A high speed, 500 frames/s, 1024×1024 CMOS active pixel sensor (2003)

The paper presents a high-speed (500 f/s) large-format 1 K/spl times/1 K 8 bit 3.3 V CMOS active pixel sensor (APS) with 1024 ADCs integrated on chip. The sensor achieves an extremely high output data rate of over 500 Mbytes per second and a low power dissipation of 350 mW at the 66 MHz master clock rate. Principal architecture and circuit solutions allowing such a high throughput are discussed along with preliminary results of the chip characterization.
Improvement of Operations and Maintenance Techniques. Near-Bed Optical Backscatter Sensor and Vector-Measuring Velocity Meter Calibration (1990)

Abstract : This report summarizes the procedures used to calibrate a Vector-Measuring Velocity Meter and an Optical Backscatter Turbidity Meter. Descriptions of facilities used in these calibration procedures are given, but they in no way limit the possibility of using other similar type facilities. Sensor thresholds and sensing limits are given to ensure accurate data collection.
Non-invasive measurement of lubricating oil viscosity using an ultrasonic continuously repeated chirp shear wave (2018)

The ability to monitor the viscosity of lubricating oils within metallic products is of interest to many industries, these being the automotive, aerospace and food industries to name a few. Acoustic mismatch at the metallic-liquid interface restricts ultrasonic signal transmission and so limits applicability and sensitivity of the technique. In this work, we propose the use of a continuously repeated chirp (CRC) shear wave to amplify the measurable acoustic response to liquid viscosity. The technique enables multiple reflections to superimpose inside the component and form a quasi-static standing wave whose amplitude spectrum depends on the condition at the solid-liquid boundary. Bare element shear ultrasonic transducers of 5 MHz resonant frequency were bonded to the lower surface of an aluminium plate in a pitch-catch arrangement to measure liquid in contact with the upper surface. Transducers were pulsed using a continuously repeated frequency sweep, from 0.5 to 9.5 MHz over 10 ms. The amplitude spectrum of the resulting standing wave was observed for a series of standard viscosity oils, which served as a calibration procedure, from which the standing wave reflection coefficient (S), was obtained. Measurements of 17 blended oils ranging in viscosity from 1080 to 6.7 mPa s were made. The technique was also evaluated with the addition of a polyimide matching layer (ML) between the metallic and liquid interface. Ultrasonic viscosity measurement values were then compared to measurements made using a conventional laboratory viscometer. The CRC method was found to significantly improve the sensitivity of viscosity measurement at a metal-liquid interface when compared to a single frequency burst with the benefit of low cost signal generation and acquisition hardware requirements. The CRC method is also capable of instant rapid response measurements as the signal responds in real time without the need to wait for a returning pulse.
A Micromachined Two-state Bandpass Filter using Series Inductors and MEMS Switches for WLAN Applications (2004)

This paper reports a novel tunable bandpass filter using two-state switched inductor with direct-contact MEMS switches for wireless LAN applications. In our filter configuration, the switched inductor is implemented to obtain more stable and much larger frequency tuning ratio compared with variable capacitor-based tunable filter. The proposed tunable filter was fabricated using a micromachining technology and electrical performances of the fabricated filter were measured. The filter consists of spiral inductors, MIM capacitors and direct-contact type MEMS switches, and its frequency tunability is achieved by changing the inductance that is induced by ON/OFF actuations of the MEMS switches. The actuation voltage of the MEMS switches was measured of 58V, and they showed the insertion loss of 0.1 dB and isolation of 26.3 dB at 2 GHz, respectively. The measured center frequencies of the fabricated filter were 2.55 GHz and 5.1 GHz, respectively. The passband insertion loss and 3-dB bandwidth were 4.2 dB and 22.5% at 2.55 GHz, and 5.2 dB and 23.5% at 5.1 GHz, respectively.
Intraspinal mesenchymal chondrosarcoma: An argument for aggressive local resection and adjuvant therapy based on review of the literature (2020)

Although uncommon, intraspinal mesenchymal chondrosarcomas warrant both radical local resection and aggressive adjuvant therapy with chemoradiation to provide the greatest chance of progression-free survival.
Enabling live internet broadcasting using an application endpoint architecture (2004)

It has been a long-standing challenge to make Internet audio/video broadcasting a commodity service. This means that anyone with a commodity Internet connection and computer equipment can broadcast high-quality video to a large group of receivers in real time. The key challenge is the bandwidth cost in distributing the video streams. To distribute 300 Kbps video stream to 100 receivers directly, a publisher must provision 30 Mbps bandwidth to the Internet. This is too expensive for most individuals to afford. The conventional wisdom is to add functionality in the underlying network infrastructure (i.e., at the IP layer). With IP Multicast, the publisher sends just one copy of the video stream to the IP network, and the network intelligently replicates the video streams to all the receivers. By shifting the task of data replication to the IP routers, IP Multicast greatly reduces the bandwidth requirements for the publishers and receivers. However, 15 years after its initial proposal, IP Multicast is still plagued with concerns pertaining to scalability, network management, deployment, and support for higher level functionality. This dissertation takes a different architecture approach to meet the challenge in broadcasting high quality video over the Internet. The author's thesis is that it is feasible today to provide video broadcasting as a commodity service, without changing the underlying IP infrastructure. He proposes a new architecture called End System Multicast. In End System Multicast, data replication is performed not by the routers, but by the receivers in the broadcast, which are end systems on the Internet. Thus, the publisher only needs to send the video stream to a few receivers, and these receivers iteratively forward the video streams to other receivers. This avoids costly bandwidth provisioning for the publisher and requires no changes to the IP infrastructure.
Radiosynthesis of [18F]FPYBF-2, a novel PET imaging probe for β-amyloid plaques in brain (2014)

1258 Objectives Recently, we developed a benzofuran derivative for the imaging of β-amyloid (Aβ) plaques, 5-(5-(2-(2-(2-[18F]fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylpyridin-2-amine ([18F]FPYBF-2) (Ono et al., J Med Chem, 54, 2971-9 2011). The aim of this study was to assess the radiosynthesis, quality control and safety assessment of [18F]FPYBF-2 using a cassette-type multipurpose automatic synthesizer module. Methods The radiosynthesis of [18F]FPYBF-2 was performed on a hybrid synthesizer, cassette-type multipurpose automatic synthesizer module (JFE Technos Corporation). The fluorination of the mesylate precursor occurred in DMSO in presence of Krypofix 2.2.2 and potassium carbonate. The mixture was then treated with aqueous HCl. After purification of the crude product by HPLC, [18F]FPYBF-2 was eluted with 2.5% ethanol in saline. The quality control tests of final products and safety assessment were performed. Results [18F]FPYBF-2 was produced in about 60 minutes with radioactivity of 13.9±1.7 GBq, radiochemical yield (decay uncorrected) of 48.6±3.7%, radiochemical purity of >98.6% and specific activity of 338.7±50.9 GBq/µmol. The products were satisfied the relevant quality standard such as the Quality Control of [18F]FDG. The reference compound was tested for toxicity in the mice. The effective dose for the adult dosimetric model was estimated to be 0.0147 mSv/MBq using OLINDA/EXM 1.1. Conclusions On this cassette-type multipurpose automatic synthesizer module, the synthesis of [18F]FPYBF-2 for clinical grade was successfully implemented in our first-in-man study with healthy volunteers and patients with dementia.
Continuous-wave and frequency domain optimization in breast tomosynthesis-guided diffuse spectroscopy (2011)

A combined tomosynthesis and diffuse spectroscopy system may provide both spatial and physiological information about breast tissue. Using patient tomosynthesis images and simulated near infrared measurements, it is possible to accurately reconstruct for hemoglobin, water and lipid concentrations. This study utilizes both frequency domain and continuous wave components, given the constraints of a projection geometry but with broadband illumination in order to accurately recover chromophore concentrations from the segmented tissue regions. This analysis will assist in determining the optimum hardware components for a combined system that is currently being built, in order to achieve the best possible accuracy in quantifying tissue properties. Comparing several different configurations including variations in the number of wavelengths, number of regions reconstructed as well as reconstruction methods within the frequency domain components of the system may decrease the complexity, cost and examination time without significant decreases in accuracy.
ChemInform Abstract: ′ACYLIERTE′ DERIVATE DES N‐METHYL‐IMIDAZOLS 1. MITT. RK. VON N‐PHOSPHORYL‐N′‐METHYL‐IMIDAZOLIUMCHLORID MIT AMINEN, DARST. VON MONOPHOSPHORAMIDEN IN WAESSRIGEM MEDIUM (1971)

Abstract Aus 1‐Methyl‐imidazol und POCl 3 entsteht bei einem pH von 11 das Phosphorylimidazoliumderivat (I), das sich mit Ba‐chlorid als Ba‐Salz isolieren läßt (Ausbeute 75%).