gebhart/patrepeval huggingface dataset:
Data from Immune Activity and Response Differences of Oncolytic Viral Therapy in Recurrent Glioblastoma: Gene Expression Analyses of a Phase IB Study (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Previously, clinical trials of experimental virotherapy for recurrent glioblastoma multiforme (GBM) demonstrated that inoculation with a conditionally replication–competent Δγ&lt;sub&gt;1&lt;/sub&gt;34.5 oncolytic herpes simplex virus (oHSV), G207, was safe. Following the initial safety study, a phase Ib trial enrolled 6 adult patients diagnosed with GBM recurrence from which tumor tissue was banked for future studies.&lt;/p&gt;Patients and Methods:&lt;p&gt;Here, we analyzed tumor RNA sequencing (RNA-seq) data obtained from pre- and posttreatment (collected 2 or 5 days after G207 injection) biopsies from the phase Ib study patients.&lt;/p&gt;Results:&lt;p&gt;Using a Spearman rank-order correlation analysis, we identified approximately 500 genes whose expression pattern correlated with survival duration. Many of these genes were enriched for the intrinsic IFN-mediated antiviral and adaptive immune functional responses, including immune cell chemotaxis and antigen presentation to T-cells. Furthermore, we show that the expression of several T-cell–related genes was highest in the patient with the longest survival after G207 inoculation.&lt;/p&gt;Conclusions:&lt;p&gt;Our data support that the oHSV-induced type I IFN production and the subsequent recruitment of an adaptive immune response differed between enrolled patients and showed association with survival duration in patients with recurrent malignant glioma after treatment with an early generation oHSV.&lt;/p&gt;&lt;/div&gt;
Current Clinical Applications of the In-capromab Pendetide Scan (ProstaScint(R) Scan, Cyt-356). (2001)

Prostate-specific antigen (PSA) has been extremely helpful in the detection of new or recurrent prostate cancer. However, localization of the recurrent tumor has been challenging with currently available radiographic modalities. The (111)In-capromab pendetide scan was developed to diagnose accurately and, more importantly, localize and stage a new or recurrent prostate cancer. Studies suggest that the (111)In-capromab pendetide scan can provide more accurate staging of clinically localized prostate cancer prior to staging lymphadenectomy or definitive therapy. It can also provide valuable information when local adjuvant radiation therapy is considered in men with biochemical cancer recurrence following radical prostatectomy.
Pyrimidin‐6‐yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis (2021)

Abstract We report a novel and general method to access a highly under‐studied privileged scaffold—pyrimidines bearing a trifluoroborate at C4, and highlight the broad utility of these intermediates in a rich array of downstream functionalization reactions. This chemistry is underpinned by the unique features of the trifluoroborate group; its robustness provides an opportunity to carry out chemoselective reactions at other positions on the pyrimidine while providing a pathway for elaboration at the C−B bond when suitably activated.
An Engineering Review of the Farm Tractor's Evolution to a Dominant Design (2018)

This paper explains the origin and merits of the dominant farm tractor design, which has endured since the 1940s. Understanding the origins and rationale for this dominant design enables engineers to appreciate its merits, and understand its drawbacks, which could be addressed in future designs. Additionally, the methods used in this paper to study tractor evolution are applicable to the study of other products with a longstanding dominant design. Two themes are covered in this paper: first, the historical context that directed the farm tractor's design evolution is presented; and second, a terramechanics-based tractor model is used to analyze why the dominant design is conducive to good performance. The prominent characteristics of the dominant tractor design are its weight distribution, wheel layout, tool location, and construction. Its weight distribution maximizes drawbar pull by placing 70 to 80% of the total vehicle weight on the rear wheels. Shifting the weight forward reduces pulling force while shifting it backward produces a negligible increase in pulling capacity while dangerously increasing the risk of upending the tractor. The tractor has four wheels arranged in a rectangular pattern—the rear wheels are driven while the front ones are usually idle. Rear wheels are of large diameter to increase ground clearance and tractive efficiency. Front wheels are of small diameter to allow for a large steering angle despite a narrow track width. A narrow track width reduces the space required for making a U-turn at field ends and improves access to farm spaces. Inline front and rear wheels are desirable for ease of driving between rows and to best harness soil compaction. Attaching implements behind the rear axle leverages tillage forces to increase maximum drawbar pull and enables using large tools. The tractor's crankcase and transmission housing are structural components—this reduces mass and manufacturing complexity.
Evaluation of Wet-Weather Pavement Markings: First Year Report (2005)

This report details the first year of a two-year project. During the first year the emphasis was on determining the wet-night visibility of various pavement marking systems under a variety of realistic rainfall levels. The researchers performed a literature review. They analyzed 20 years of Texas rainfall data to determine the most appropriate rainfall levels to use as design criteria for a rain tunnel. Using a low, medium, and high rainfall rate (0.28, 0.52, and 0.87 in. per hour, respectively), a 1600 ft long rain tunnel was designed and built at Texas A&M University's Riverside Campus. Experimental subjects drove through the rain tunnel and looked for pavement markings simulating skip lines. The researchers rotated pavement marking samples at different locations before each trial. The detection distance was recorded when the subject located the pavement marking sample. The data were analyzed in four main sections: waterborne paints, thermoplastics, tapes, and exotic materials. The analysis also included investigations into the wet-night visibility of rumble stripes, as well as wider lines. The measured dry and wet retroreflectivity measurements were analyzed, and the predictive capabilities of the wet retroreflectivity measurements were evaluated with respect to the wet-night detection distance of the markings. During year two the researchers will supplement the detection distance data with additional data from a second round of wet-night visibility experiments. The researchers will also consider durability and cost information before finalizing the research. The researchers will also develop and implement research activities that can be used to develop application recommendations for contrast pavement marking materials based on visibility performance, durability, and cost.
The Funding Game: Rules for Public Library Advocacy (2001)

The Funding Game presents various examples of library advocacy and cites a variety of community inputs, so that library administrators, board members, and Friends, will have better insight into possibilities for their own library's funding advantage.
Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2 (2000)

Phosphorylation of myosin II regulatory light chains (RLC) by Ca(2+)/calmodulin-dependent myosin light chain kinase (MLCK) is a critical step in the initiation of smooth muscle and non-muscle cell contraction. Post-translational modifications to MLCK down-regulate enzyme activity, suppressing RLC phosphorylation, myosin II activation, and tension development. Here we report that PAK2, a member of the Rho family of GTPase-dependent kinases, regulates isometric tension development and myosin II RLC phosphorylation in saponin permeabilized endothelial monolayers. PAK2 blunts tension development by 75% while inhibiting diphosphorylation of myosin II RLC. Cdc42-activated placenta and recombinant, constitutively active PAK2 phosphorylate MLCK in vitro with a stoichiometry of 1.71 +/- 0. 21 mol of PO(4)/mol of MLCK. This phosphorylation inhibits MLCK phosphorylation of myosin II RLC. PAK2 catalyzes MLCK phosphorylation on serine residues 439 and 991. Binding calmodulin to MLCK blocks phosphorylation of Ser-991 by PAK2. These results demonstrate that PAK2 can directly phosphorylate MLCK, inhibiting its activity and limiting the development of isometric tension.
Contextual Descriptors for Scene Classes in Very High Resolution SAR Images (2011)

The new generation of spaceborne SAR instruments with meter or submeter resolution finds enormous applications for the observation of urban, industrial, in general of man-made scenes. Thus, targets are not any more observed in isolation, instead the groups of objects, e.g., house, bridge, and road, etc., need to be recognized in their spatial context. This paper proposes a feature extraction method for image patches in order to capture the spatial context. The method is based on the characteristics of the spectra of the SAR data, integrating radiometric, geometric, and texture properties of the SAR image patch. The method is demonstrated for TerraSAR-X High Resolution Spotlight data. To account for the spatial context in which a group of targets is located, it uses an image patch covering typically 200 × 200m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of the scene. A comparative evaluation of our descriptors and grey-level co-occurrence matrix (GLCM) texture features has been performed over a database of 6916 patches. The method allowed for the robust recognition of over 30 different scene classes, with precision between 50% and 93%. Numerical results show that our method is able to discriminate between scene classes better than GLCM texture parameters.
Realizing autonomics for future networks (2011)

While there has been undeniable progress in the field of autonomic networking research over the past several years, widespread deployments of self-management techniques are still missing. At the same time the need for techniques enabling the transformation of operational models, the evolution towards more flexible networks is becoming more and more evident. Further, most efforts have been focused on solving manageability bottlenecks in a given technological domain, while communication services extend anywhere, regardless of the technological boundaries (e.g. wireline/wireless). This paper presents an end-to-end and modular approach for the realization of future autonomic networks, focusing on common management and information substrates semantically enriched, on network empowerment mechanisms providing reasoning embodiment right into the network systems, and on the establishment of a reference trust framework for large-scale deployment and adoption. © 2011 IIMC.
Design and Experimental Research of Expansion-Anchorage Device in Deepwater Pipeline (2019)

Anchoring device is one of the key technologies of deep water pipeline internal packer. In this paper, the structural design of the anchorage device is completed on the basis of the principle of the inclined plane reinforced structure and elastoplastic mechanics, and its three-dimensional model and mechanical model are established. Theoretical research and simulation analysis of the strength of key parts of the anchoring device are carried out, with emphasis on the design of the anchoring block, material selection, anchoring depth between the anchoring block and the inner wall of the pipe, and theoretical and simulation research of the contact stress. The correctness of theory and simulation analysis is verified by anchoring experiment. The research content of this paper can lay a foundation for the design and research of anchoring device.
Neuromyelitis optica following human papillomavirus vaccination (2012)

The quadrivalent human papillomavirus (HPV) vaccine Gardasil (Merck & Co., Whitehouse Station, NJ) (qHPV-vac) was recently approved for immunization of adolescent girls to prevent cervical cancer.[1][1] Recently, 5 cases of multiple sclerosis (MS) were reported following qHPV-vac vaccination.[2][2]
CSF transthyretin neuroprotection in a mouse model of brain ischemia (2010)

Brain injury caused by ischemia is a major cause of human mortality and physical/cognitive disability worldwide. Experimentally, brain ischemia can be induced surgically by permanent middle cerebral artery occlusion. Using this model, we studied the influence of transthyretin in ischemic stroke. Transthyretin (TTR) is normally responsible for the transport of thyroid hormones and retinol in the blood and CSF. We found that TTR null mice (TTR(-/-) ) did not show significant differences in cortical infarction 24 h after permanent middle cerebral artery occlusion compared with TTR(+/+) control littermates. However, TTR null mice, heterozygous for the heat-shock transcription factor 1 (TTR(-/-) HSF1(+/-) mice), which compromised the stress response, showed a significant increase in cortical infarction, cerebral edema and the microglial-leukocyte response compared with TTR(+/+) HSF1(+/-) mice. Unexpectedly, we observed novel TTR distribution throughout the infarct, localized to disintegrated β-tubulin III(+) neurons and cell debris. Specific elimination of TTR synthesis in the liver by RNAi had no effect on TTR distribution in the infarct, indicating that the observed TTR infiltration derived from CSF and not from the serum. This finding is corroborated by results from 'in situ' hybridization and real time PCR that excluded the presence of transthyretin mRNA in the infarct and peri-infarct areas. Our data suggest that in conditions of a compromised heat-shock response, CSF TTR contributes to control neuronal cell death, edema and inflammation, thereby influencing the survival of endangered neurons in cerebral ischemia.
An improved process for the synthesis of nintedanib esylate (2017)

Nintedanib esylate is synthesized via novel intermediates of (Z)-methyl 3-(acetoxy-phenyl)methylene)-1-acetyl-2-oxoindoline-6-carboxylate and N-(4-aminophenyl)-2-chloro-N-methylacetamide in good yields.
New Department, Editors, and Awards (2012)

EIC Gabriel Taubin introduces a new department, two new editorial board members, and the winner of the 2011 CG&A Best Paper Award.
Nonlinear models of some ring oscillators (2008)

We develop here higher-order nonlinear models of three-stage and five-stage ring oscillators based on a novel inverter model. The oscillation condition and oscillation frequency are derived and compared to classical linear model analysis. An important special case for five-stage ring oscillators is also modelled.
Table S2 from Phase II Drug-Metabolizing Polymorphisms and Smoking Predict Recurrence of Non–Muscle-Invasive Bladder Cancer: A Gene–Smoking Interaction (2023)

&lt;p&gt;Interaction between smoking (3 categories) and UGT1A1 genetic status (dominant model) in Cox multivariate model and the risk of bladder cancer recurrence.&lt;/p&gt;
Liquid metal architectures for soft and wearable energy harvesting devices (2020)

Abstract Future advanced wearable energy harvesters need to have high power densities, functionality under large deformations, scalability, and robust resistance against mechanical damages (i.e. fatigue, delamination, and fracture). To achieve this, ultra-flexible, high dielectric, and thermally conductive materials along with deformable and robust electrodes are needed. Here, we review recent progress in synthesis and integration of liquid metal (LM) material architectures as the building blocks of emerging wearable energy harvesting devices. After a brief introduction to room temperature LM alloys, LM’s various applications in a variety of soft and stretchable power harvesting devices including thermoelectric, triboelectric, dielectric elastomer, and piezoelectric generators are summarized. The unique opportunities and challenges introduced by LM material architectures in this field are also discussed.
Study of Surface Structure of Hair of Some Primates of Indian Sub-Continent (1993)

No Abstract.
Nucleobase-Specific Quenching of Fluorescent Dyes. 1. Nucleobase One-Electron Redox Potentials and Their Correlation with Static and Dynamic Quenching Efficiencies (1996)

Intermolecular static and dynamic fluorescence quenching constants of eight coumarin derivatives by nucleobase derivatives have been determined in aqueous media. One common sequence of the quenching efficiency has been found for the nucleobases. The feasibility of a photoinduced electron transfer reaction for the nucleobase-specific quenching of fluorescent dyes is investigated by the calculation of the standard free energy changes with the Rehm−Weller equation. A complete set of one-electron redox potential data for the nucleobases are determined electrochemically in aprotic solvents for the first time, which are compared with values obtained by various other methods. Depending on the redox properties of the fluorescent dyes, the sequences of the quenching efficiencies can be rationalized by the orders of electrochemical oxidation potentials (vs NHE) of nucleosides (dG (+1.47 V) < dA < dC ≈ dT < U (≥ +2.39 V)) and reduction potentials (dG (< −2.76 V) < dA < dC < dT < U (−2.07 V)). The correlation between the intermolecular dynamic quenching constants and the standard free energy of photoinduced electron transfer according to the classical Marcus equation indicates that photoinduced electron transfer is the rate-limiting step. However, an additional, water-specific gain of free energy between −0.5 and −0.9 eV shows that additional effects, like a coupled proton transfer and a hydrophobic effect, have to be considered, too. Furthermore, the capability of the nucleobases to form ground state complexes with fluorescent dyes is influenced by their redox potentials. The relevance of these observations to current efforts for DNA sequencing with a detection by laser-induced fluorescence and their application to other dyes are discussed.
Mutagenic Activity of N-(n-octyl)-glutarimide and Proprietary Compound CHR 8 Using the Drosophila melanogaster Sex-Linked Recessive Lethal Test. (1982)

Abstract : N-(N-octyl)-glutarimide and Proprietary Compound CHR 8 are both insect repellents being considered for use among personnel in the field. Both compounds were tested for mutagenic activity by using Drosophila melanogaster Sex-linked Recessive Lethal Assay and were found to be mutagenic after 72-hr feeding exposures to 70mM and 90mM of N-(n-octyl)-glutarimide, and 55 mM and 70 mM of Proprietary Compound CHR 8. (Author)
Cloning and Characterization of bla VIM , a New Integron-Borne Metallo-β-Lactamase Gene from a Pseudomonas aeruginosa Clinical Isolate (1999)

Production of a metallo-beta-lactamase activity was detected in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate (isolate VR-143/97) from an Italian inpatient at the Verona University Hospital (northern Italy). The metallo-beta-lactamase determinant was isolated from a genomic library of VR-143/97, constructed in an Escherichia coli plasmid vector, by screening for clones with reduced susceptibility to imipenem. Sequencing of the cloned gene revealed that it encoded a new class B beta-lactamase that was named VIM-1. At the sequence level VIM-1 was rather divergent from the other class B enzymes (16.4 to 38.7% identity), overall being more similar to members of subclass B1 including the beta-lactamase II of Bacillus cereus (Bc-II), the Bacteroides fragilis CcrA, the Chryseobacterium meningosepticum BlaB, and the cassette-encoded IMP-1 enzymes. Among these, VIM-1 showed the highest degree of similarity to Bc-II. Similarly to blaIMP, blaVIM was also found to be carried on a gene cassette inserted into a class 1 integron. The blaVIM-containing integron was located on the chromosome of P. aeruginosa VR-143/97, and the metallo-beta-lactamase-encoding determinant was not transferable to E. coli by conjugation. Expression of the integron-borne blaVIM gene in E. coli resulted in a significant decrease in susceptibility to a broad array of beta-lactams (ampicillin, carbenicillin, piperacillin, mezlocillin, cefotaxime, cefoxitin, ceftazidime, cefoperazone, cefepime, and carbapenems), revealing a very broad substrate specificity of the VIM-1 enzyme.
Supplementary Figure 7 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2 (2023)

&lt;p&gt;Supplementary Figure 7&lt;/p&gt;
A navigation system for unmanned vehicles in automated highway systems (2003)

In this paper, a new method for generating a set of collision-free maneuvers for unmanned vehicles in automated highway systems is introduced. The low computational cost of the proposed maneuver planner allows its execution as frequent as the new positions and speeds of vehicles (obstacles) in sight are received. This planner is based on the computation of the minimum translational distance between two mobile objects. This distance is then used for predicting and avoiding a collision, generating (if it is possible and safe), overtaking (changing to the left and right lane), braking and keeping-the-lane maneuvers. These maneuvers can be provided to a decision-making process for selecting the most suitable one.
Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells†‡ (2005)

Phospholipase A(2) IIA (PLA(2)IIA), which plays a crucial role in arachidonic acid metabolism and in inflammation, is upregulated under various pathological conditions, including in the gallbladder and gallbladder bile from patients with multiple cholesterol gallstones, in the liver and kidney of rats with cirrhosis, as well as in the colonic tissue of animals treated with a chemical carcinogen. The administration of ursodeoxycholic acid (UDCA) partially attenuated the PLA(2)IIA expression level in these different models. The aim of this study was to investigate the modulatory effect of UDCA on the PLA(2)IIA expression level at the cellular level. The HepG2 cells were selected to investigate the direct inhibitory effect of UDCA on PLA(2)IIA expression level. The proinflammatory cytokines (interleukin-6 and tumor necrosis factor alpha) -induced PLA(2)IIA expression in HepG2 cells was partially inhibited by the presence of UDCA in a dose-dependent fashion. The effect of UDCA on proinflammatory cytokines-induced PLA(2)IIA expression occurred at the transcriptional level. In addition, among the bile acids tested, this inhibitory effect was UDCA-specific. In conclusion, this study supports the possible alteration of arachidonic acid metabolism and PLA(2)IIA expression level, in particular, as the protective action of UDCA in patients with chronic liver disease.