gebhart/patrepeval huggingface dataset:
Expression of the Hox gene complex in the indirect development of a sea urchin (1998)

Hox complex genes control spatial patterning mechanisms in the development of arthropod and vertebrate body plans. Hox genes are all expressed during embryogenesis in these groups, which are all directly developing organisms in that embryogenesis leads at once to formation of major elements of the respective adult body plans. In the maximally indirect development of a large variety of invertebrates, the process of embryogenesis leads only to a free-living, bilaterally organized feeding larva. Maximal indirect development is exemplified in sea urchins. The 5-fold radially symmetric adult body plan of the sea urchin is generated long after embryogenesis is complete, by a separate process occurring within imaginal tissues set aside in the larva. The single Hox gene complex of Strongylocentrotus purpuratus contains 10 genes, and expression of eight of these genes was measured by quantitative methods during both embryonic and larval developmental stages and also in adult tissues. Only two of these genes are used significantly during the entire process of embryogenesis per se, although all are copiously expressed during the stages when the adult body plan is forming in the imaginal rudiment. They are also all expressed in various combinations in adult tissues. Thus, development of a microscopic, free-living organism of bilaterian grade, the larva, does not appear to require expression of the Hox gene cluster as such, whereas development of the adult body plan does. These observations reflect on mechanisms by which bilaterian metazoans might have arisen in Precambrian evolution.
Using distance maps for accurate surface representation in sampled volumes (1998)

Article Free Access Share on Using distance maps for accurate surface representation in sampled volumes Author: Sarah F. F. Gibson MERL- A Mitsubishi Electric Research Laboratory, 201 Broadway, Cambridge, WA MERL- A Mitsubishi Electric Research Laboratory, 201 Broadway, Cambridge, WAView Profile Authors Info & Claims VVS '98: Proceedings of the 1998 IEEE symposium on Volume visualizationOctober 1998 Pages 23–30https://doi.org/10.1145/288126.288142Published:01 October 1998Publication History 81citation1,385DownloadsMetricsTotal Citations81Total Downloads1,385Last 12 Months50Last 6 weeks10 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Multiple freeze‐thaw cycled meniscal allograft tissue: A biomechanical, biochemical, and histologic analysis (2007)

Meniscus allografting has provided relief of meniscal injuries that were previously thought irreparable. However, meniscus allograft tissue remains limited and a significant problem. To improve allograft tissue yield, decrease processing costs, and increase graft availability, this study investigated the biomechanical changes of meniscal allograft tissue frozen and thawed multiple times. Specifically, our study compared the intrinsic compressive resistances of meniscus undergoing four Freeze-Thaw cycles versus tissue undergoing a single Freeze-Thaw cycle. Seven menisci that were originally procured and processed for allografting were donated for the study. Each meniscus was segmented and samples independently underwent novel constant slow-rate compression testing, and histological and biochemical evaluation. The menisci that underwent a single Freeze-Thaw cycle demonstrated a significantly higher Young's Modulus (14 megapascals) as compared to menisci undergoing multiple Freeze-Thaw cycles (10 megapascals, p = 0.03). These results were maintained when medial and lateral menisci were compared independently. Histological and biochemical analyses supported, but did not provide an explanation for the change in intrinsic compressive resistance. From these results, transplantation of meniscal allograft tissue frozen and thawed four times may be compromised in its ability to resist compression; and thus may undermine its role in replacing native meniscal tissue.
[Minimally invasive treatment of colorectal cancer]. (2001)

It may be widely interpreted that minimally invasive treatment of colorectal cancer includes endoscopic mucosal resection, transanal endoscopic microsurgery (TEM), laparoscopic surgery and open reduction-surgery as well as adjuvant treatments such as chemotherapy, radiotherapy and thermotherapy. With the development of medical technology and instruments, we have now a wide and new range of choices for each cancer stage of patients. However, it is not yet clear that minimally invasive treatment necessarily leads to better results in survival and recurrent rates of the patients, as compared with conventional surgery. We should therefore take into full consideration the lingering problems in selecting the new therapies. In this paper, we show the strong and weak points of laparoscopic surgery, TEM, right hemi-colectomy preserving Bauhin's valve and adjuvant radiotherapy for lower rectal cancer, and discuss ongoing problems.
MACS: music audio characteristic sequence indexing for similarity retrieval (2002)

We present a prototype method of indexing raw-audio music files in a way that facilitates content-based similarity retrieval. The algorithm tries to capture the intuitive notion of similarity perceived by humans: two pieces are similar if they are fully or partially based on the same score, even if they are performed by different people or at different speed. Local peaks in signal power are identified in each audio file, and a spectral vector is extracted near each peak. Nearby peaks are selectively grouped together to form "characteristic sequences" which are used as the basis for indexing. A hashing scheme known as "locality-sensitive hashing" is employed to index the high-dimensional vectors. Retrieval results are ranked based on the number of final matches filtered by some linearity criteria.
Effect of Dimensional Variation on Induction Process Parameters Using 2D Simulation (2011)

The induction heating is a surface heat treatment that exhibits some relevant industrial advantages. In fact, the process is not energy-consuming compared to thermo-chemical processes such as carbonizing and nitriding because it allows generating high power and focusing it locally and during a short time to achieve hardness at the surface area without affecting the part core. Using no plating phase, the induction heating process is qualified as green and sustainable manufacturing process but should be better understood to help developers to reach optimized recipes in a small number of process iterations. Globally, for a given range of parts to be manufactured, one has to proper select the frequency and power of the equipment to be. This work will show how part geometry, generator frequency and power are closely linked. This work is carried principally by simulation efforts using computer-modeling software (COMSOL). A developed 2D model includes the coupling between electro-magnetic and thermal fields, and takes account of the non-linear behavior of material properties versus temperature. The simulation allows optimizing the machine according to the dimensions of gear. This paper also proposes a method to approximate the power amount required to achieve a desired hardness profile.
P92 Possible case of donovanosis successfully treated with co-amoxiclav (2022)

<h3>Introduction</h3> Donovanosis is a rare infection in the UK, however, it’s a cause of genital ulceration. We present a case of possible Donovanosis successfully treated with Co-amoxiclav. Case report: A 66-year-old Caucasian male presented with a 6- week history of scrotal and groin ulceration after unprotected vaginal sex with casual female. On examination 3 lesions were seen: one in each groin and scrotal skin, these were fleshy, moist beefy red in colour with tissue destruction. No penile ulcers or lymphadenopathy noticed. Dark ground and HSV PCR negative. Giemsa satin was negative however the sample contained inadequate cellular material and was only repeated when co-amoxiclav had been commenced. He tested negative for syphilis and HIV. He was initially treated with erythromycin 500mg qds for 7 days by the GP, some response but symptoms recurred after completion. Culture initially tested positive for Klebsiella species; PCR closely match to Klebsiella garnulomatis. He was treated with Co-amoxiclav 500/125 mg tds for 3 weeks and lesions completely resolved. <h3>Discussion</h3> We describe a case of possible Donovanosis successfully treated with 3-week course of Co-amoxiclav. The cause was thought to be Calymmatobacterium garnulomatis, but new evidence suggests reclassifying the organism as Klebsiella garnulomatis which was found in this patient<sup>1</sup>. Many Sexual health clinics like ours now operate from community setting without direct access to pathology labs. It is important to discuss communicate with microbiology team. In conclusion this case demonstrate clinicians needs to consider rare causes in unusual presentation and the importance of working with local microbiology team. <h3>Reference</h3> Carter J, Bowden FJ, Bastian I, et al. Phylogenetic evidence for reclassification of Calymmatobacterium granulomatis as Klebsiella granulomatis comb nov. Int J Syst Bacteriol 1999; 49: 1695–1700.
Stratigrafie van het Onder-Krijt in Zuidoost-Frankrijk (1988)

Het Onder-Krijt is de laatste periode uit het Mesozoicum waarin geologisch gezien weinig gebeurde in ZuidoostFrankrijk. In het gebied bevond zich een groot zeebekken met een diepte van 800 tot 1500 meter. Dit zeebekken stond naar het zuiden in open verbinding met de Tethyszee. Op afb. 1 zien we dat het bekken omgrensd werd, en wordt, door metamorfe en vulkanische gesteenten: oude eilanden uit het Paleozoicum. De zwarte stukken op de kaart geven aan waar we de afzettingen uit het Onder-Krijt aan de oppervlakte kunnen vinden. In het midden van het gebied vinden we de typische diepzeeafzettingen waarin voornamelijk ammonieten en belemnieten voorkomen, tegen de eilanden vinden we een kustfauna: met voornamelijk zeeegels, lamellibranchiaten en gastropoden. In het zeebekken werden in het gehele Onder-Krijt mergel- en kalklagen afgezet. In de buurt van St. Andre-les-Alpes bij het Meer van Castillon bedraagt de totale dikte van die lagen 630 meter, elders meer dan 800 meter.
Discrete charging of a quantum dot strongly coupled to external leads (2004)

We examine a quantum dot with $N_{\rm dot}$ levels which is strongly coupled to leads for varying number of channels $N$ in the leads. It is shown both analytically and numerically that for strong couplings between the dot and the leads, at least $N_{\rm dot}-N$ bound states (akin to subradiant states in optics) remain on the dot. These bound states exhibit discrete charging and, for a significant range of charging energies, strong Coulomb blockade behavior as function of the chemical potential. The physics changes for large charging energy where the same (superradiant) state is repeatedly charged.
Abstract 185: Utilization of Nanoformulated Copper/Zinc Superoxide Dismutase (CuZnSOD) to Attenuate the Central Angiotensin II-Induced Pressor Response (2012)

Elevated levels of superoxide (O 2 .- ) in the brain and dysregulation of angiotensin II (AngII)-dependent neural mechanisms are associated with cardiovascular diseases, such as hypertension. For improved brain delivery of CuZnSOD protein, a O 2 .- -specific scavenging enzyme, we developed SOD nano, a polyion complex with a polyethylene glycol corona and polyethyleneimine core that electrostatically binds CuZnSOD protein. Our previous studies in cultured neurons indicate that SOD nano enters neurons through active endocytosis and localizes to various organelles where it scavenges O 2 .- and effectively inhibits AngII intra-neuronal signaling. Here, we hypothesized that centrally administered SOD nano ameliorates AngII-dependent neurogenic hypertension by delivering functional CuZnSOD protein to AngII sensitive brain regions. For these studies, C57Bl/6 male mice were instrumented with carotid catheter radiotelemeters to record mean arterial pressure (MAP). Intracerebroventricular (ICV) cannulae were implanted for the administration of SOD nano and daily injections of AngII (350 ng) before and after SOD nano treatment. The average AngII-induced increase in MAP for 3 days prior to treatment was 9.2 + 0.7 mmHg. ICV-administered SOD nano (113 U SOD activity) significantly inhibited the acute, central AngII pressor response for at least 3 days (ΔMAP D1= 1.3 + 1.4 mmHg; D2 = -2.7 + 3.7 mmHg; D3 = 3.4 + 4.1; n=3, p&lt; 0.05 vs. AngII response 3 days prior). In contrast, ICV-administered saline did not alter the AngII-induced pressor response (ΔMAP D1 = 8.0 + 2.8 mmHg, D2 = 9.6 + 1.5, D3 = 7.3 + 1.2, n=4). Additionally, free CuZnSOD protein (ICV, 113 U SOD activity) did not attenuate the central AngII pressor response (ΔMAP D1 = 6.6 + 0.4 mmHg, D2 = 10.7 + 2.3, D3 = 16.3 + 8.4, n=2); thus, suggesting enhanced stability and/or cellular uptake of the SOD nano compared to free protein. Notably, the distribution of fluorescently labeled SOD nanozyme administered ICV was detected throughout the ventricular system, primarily in ependymal cells lining the brain ventricles and in the choroid plexus. These data suggest that this nanotechnology approach is effective in delivery CuZnSOD protein in vivo to AngII sensitive brain regions where it inhibits brain angiotensinergic signaling.
Development and validation of high-performance liquid chromatography method for determination of some pesticide residues in table grape (2017)

This study presents the development and validation of a new reversed-phase high-performance liquid chromatography (RP-HPLC) method for simultaneous determination of captan, folpet, and metalaxyl residues in table grape samples with ultraviolet–diode array detection (UV–DAD). Successful separation and quantitative determination of analytes was carried out on LiChrospher 60 RP-select B (250 × 4 mm, 5 μm) analytical column. Mixture of acetonitrile–0.1% formic acid in water (65:35, v/v) was used as a mobile phase, with flow rate of 1 mL/min, constant column temperature at 25 °C, and UV detection at 220 nm. The target residues were extracted with acetone by ultrasonication, followed by a cleanup using liquid–liquid extraction (LLE) and solid-phase extraction (SPE). The obtained values for multiple correlation coefficients ( R 2 &gt; 0.90), relative standard deviation (RSD) of retention times, peak areas and heights (RSD ≤ 2.25%), and recoveries ranging from 90.55% to 105.40%, with RSD of 0.02% to 5.37%, revealed that the developed method has a good linearity, precision, and accuracy for all analytes. Hence, it is suitable for routine determination of investigated fungicides in table grape samples.
Volar percutaneous transtrapezial fixation of scaphoid waist fractures: surgical technique. (2012)

Percutaneous screw fixation of scaphoid fractures has gained popularity over the years. The disadvantages of a long period of cast immobilisation are avoided and this technique allows a more rapid return to work and sports activities than conservative treatment. Consequently, percutaneous screw fixation is appealing for the young and active population. Biomechanical studies showed that greater fixation strength is obtained when the screw is placed centrally than eccentrically. Central screw placement can however be technically demanding. In the use of a volar percutaneous approach, the trapezium and the shape of the scaphoid impede central screw placement. Different approaches are available to overcome this difficulty. The volar percutaneous transtrapezial approach facilitates and allows more accurate central screw placement compared to approaches that try to avoid the trapezium. The surgical technique of this approach is described.
Near Orthogonal Oversampled Graph Filter Banks (2016)

A framework for oversampled filter banks for graph signals was recently proposed by Tanaka and Sakiyama (2014). It was shown that M-channel oversampled filter bank which is exactly orthogonal is not possible with polynomial spectral filter functions. The result is an extension of the critically sampled framework of Narang and Ortega (2012). In this work we present a solution that is nearly orthogonal which has the advantage of giving a nearly tight transform, i.e. nearly equal frame bounds. A family of target functions which satisfy the orthogonality condition is constructed using Bernstein polynomials. The design of the spectral filters is easily achieved through an approximation of the target functions. Filters with good spectral characteristics that are nearly orthogonal can be easily obtained using the proposed method.
Static and Dynamic Properties of Nonlinear Semiconductor Laser Amplifiers (1986)

Optical memory, differential amplification and optical limiting have been experimentally achieved in an AlGaAs laser amplifier, demonstrating the feasibility of nonlinear optical signal processing using semiconductor laser amplifiers. The results of the analysis of the dynamic properties of semiconductor laser amplifiers are also presented; subnanosecond and femto-Joule switching, critical slowing down and output spiking due to self-tuning at the onset of light injection have been analyzed.
Steroid Elution Improves the Stimulation Threshold in an Active-Fixation Atrial Permanent Pacing Lead (1995)

Background Prior work suggests that the addition of a steroid-eluting reservoir to a passive-fixation permanent pacemaker lead improves the stimulation threshold; however, no large randomized study has addressed this issue. Over the last several years, there has been an increase in enthusiasm for the use of active-fixation permanent pacemaker leads for various reasons in spite of the generally accepted notion that active-fixation leads have higher stimulation thresholds. Methods and Results This multicenter, randomized, controlled study examined the difference in performance between a standard active-fixation atrial lead (Medtronic model 4058) and a steroid-eluting lead (Medtronic model 4068). Stimulation thresholds were obtained in a four-point strength-duration fashion. Evaluations of sensing and impedance were performed as well. These evaluations were performed at implantation, at weeks 1 through 4, and at weeks 6, 12, 24, and 52. Stimulation thresholds were significantly better in the steroid lead than in the nonsteroid lead at each measurement point from 1 week to 12 months. The mean 1.6-V stimulation threshold at 12 months was 0.19±0.2 ms in the steroid lead and 0.41±0.30 ms in the control lead. No acute peaking was observed with the steroid lead, whereas significant peaking was observed with the control lead. There was no difference in long-term sensing or impedance. Conclusions Inclusion of a steroid-eluting reservoir in an active-fixation permanent pacing lead improved stimulation thresholds in both the subacute and chronic periods and therefore should extend pulse-generator longevity.
ChemInform Abstract: Highly Chemo‐ and Enantioselective Hydrogenation of Linear α,β‐Unsaturated Ketones. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structure elucidation and purity assay of ADAM by HPLC and LC-ESI-MS/MS (2007)

1416 Objectives: 2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine (ADAM) is a high affinity ligand for serotonin transporters. Following the labeling with radioisotopes, I-123, I-124 or F-18, it can be used as a SPECT or PET imaging agent for psychiatric disorders, i.e., depression diagnosis. The purpose of this study was intended to follow the chemistry, manufacturing and control (CMC) guidance for developing a structure elucidation, purity assay method and stability study of I-127-ADAM (‘cold-ADAM’) as well as its precursor SnADAM. Methods: The studies were achieved using an Agilent 1100 series HPLC coupled with a photodiode-array detector. Structure elucidation of I-127-ADAM and SnADAM were carried out by product ion scan, precursor ion scan and neutral loss scan using an API 4000 QTrap ESI-MS/MS system. A C-18 reversed phase column was employed with an isocratic eluent of methanol-acetonitrile (50:50, v/v). Results: Molar extinction coefficient (at 220 nm) of SnADAM in methanol was increasing gradually and arrived +9.77 % within 50 hrs, shown that poor correlation of calibration curves. However, the coefficient variation of purity (based on the % peak areas) of SnADAM was less than 0.14 % within 50 hrs, indicating that SnADAM in methanol was still stable for purity assay. Retention time of SnADAM and Iodine-ADAM were found of 6.636 ± 0.021 min (RSD = 0.31%, n = 36, inter-day precision) and 3.648 ± 0.015 min (RSD = 0.41%, n = 9, intra-day precision), respectively. The chromatographic resolution between Iodine-ADAM and its precursor (SnADAM) was 11.2. Several impurities of SnADAM with m/z of 237.4, 281.4, 301.6 and 393.6, were found and elucidated. The major mass transitions of product ion scan were from m/z 549.4 to 235.1, 178.6 and 166.1 for SnADAM, and from m/z 385.1 to 340.4, 213.3, 196.4 and 166.1 for I-127-ADAM. Conclusions: An optimized purity assay method for SnADAM and Iodine-ADAM were well developed and validated. Structure elucidation of SnADAM, Iodine-ADAM and impurities were achieved. Research Support (if any): Supported by a grant from Executive Yuan, Taiwan.
Beyond the desktop (2000)

Two key challenges will rapidly change the character of computing: the growing divergence of computer platforms and the increasing use of rich media in engaging users. As human-computer interaction (HCI) professionals, we must consider the difficulties of designing systems that will run on both tiny hand-held devices and large wall displays. We must also keep in mind that the emerging generation of users not only expects but demands that systems be engaging, entertaining, and contain a variety of media types. The role of artists and media professionals on software development teams will increase and the skills of these team members will be necessary to deliver the values, esthetics, and overall quality of experience that future systems require.
A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast Saccharomyces cerevisiae exposed to distinct antimicrobial peptides (2010)

Reinforcement of CW is a general response common after exposure to distinct AMP, and likely contributes to shield cells from peptide interaction. However, a weakened CW is not necessarily indicative of a higher sensitivity to AMP. Additional processes modulate susceptibility to specific peptides, exemplified in the involvement of the metabolism of amino groups in the case of PAF26. The relevance of the response to unfolded protein stress or the sphingolipid biosynthesis, previously reported for other unrelated AMP, was also independently confirmed.
Design of Power Delivery Network Droops (2021)

Based on a simple and typical power delivery network structure, the impedance profile is expressed in a novel form through a complicated derivation and then the Fourier transform is used to calculate the time-domain impedance response. After that, an exactly analytical formula of the load voltage droop induced by an ideal current step is derived. The analytical results are exactly matched with the commercial simulation tool. The resonant frequency is derived, and its damped property is discussed. Through the properties derived from the simple structure, a more complicated power delivery network is designed in control. The step current response in time-domain is also simulated to show the voltage droops, as the design expected.