gebhart/patrepeval huggingface dataset:
Can Elite Dancers Return to Dance after Ultrasound-Guided Platelet-Rich Plasma (PRP) Injections? (2018)

Dancers exert tremendous stresses on the lower extremities rendering them prone to injuries that can curtail training and performance. The goal of this study was to evaluate clinical improvement in a population of elite dancers following treatment with ultrasound-guided platelet-rich plasma (PRP) injections of various lower extremity sites by assessing when they were able to return to dance. Nineteen dancers (13 female, 6 male; ages 15 to 42) were treated between 2009 and 2016 at sites that included: hamstring tendon (1), proximal iliotibial band (1), patellar tendon (3), posterior tibial tendon (5), peroneus brevis tendon (3), plantar fascia (3), and the first metatarsophalangeal (MTP) joint capsule (3). Injections were performed by a single radiologist using the same PRP kit under ultrasound guidance. All patients adhered to standard post-care instructions, including non-weightbearing and avoidance of NSAIDs for at least 2 weeks post-injection. Clinical charts were reviewed for factors including: adherence to post-injection immobilization and physical therapy, physical exam assessments, and milestones in returning to dance. The time-point for returning to dance was defined by attendance of class or rehearsal without symptoms referring to the treated site. Eighteen subjects achieved return to dance, 13 in 6 months or less, and the majority (10) within 3 months of injection. Five subjects required more than 6 months recovery time. These cases all involved foot and ankle sites; of these, two subjects required repeat injections, and both returned to dance within 11 months of the second injection. In the single case where PRP treatment failed, the injury treated was severe plantar fasciopathy with a high-grade central cord tear. It is concluded that ultrasound-guided PRP injections may play a role in the treatment of various lower extremity injuries in elite dancers, with the majority of subjects in this series returning to dance within 6 months. Recovery time may vary depending on the site treated and severity of the presenting injury.
The Effect of Curcumin on Corneal Neovascularization in Rabbit Eyes (2010)

Topical application of curcumin was useful in reducing experimental corneal neovascularization and can be used to inhibit angiogenesis in the cornea.
Feature point extraction in compressed domain (2003)

This document presents several approaches to extract interest points within compressed images (based on DCT compression methods). The goal is to minimize the stages and/or the calculation costs for image sequence indexing tasks or database retrieval from a significant MPEG file repository. Initially, only the fixed images (I-Frames) are take under consideration, motion will be integrated in further research. The traditional invariant feature points (Harris corner points, points with remarquable principal curvatures) are extracted from images using a gradient estimate (first order derivative) or the Laplacian (second-order derivative) of an image. So the first part of this paper handles in detail the derivation of the signal from DCT blocks. The trials to implement feature points detection as close as possible to the DCT coefficient are explained. Results provided by our last DCT-blockwise curvature estimatiorare also shown.
Mutational Analysis of the Androgen Receptor Using Laser Capture Microdissection and Direct Sequencing (2003)

Molecular analysis of prostate cancer specimens is complicated by tumor heterogeneity and admixture of malignant cells with benign epithelium, stroma and inflammatory cells. Laser Capture Microdissection allows procurement of selected groups of cells from specific areas of tissue sections. We have used Laser Capture Microdissection to obtain pure samples of malignant prostate epithelial cells from frozen radical prostatectomy specimens. Methods for DNA extraction, androgen receptor amplification and exon sequencing have been optimized. These methods should be adaptable for molecular analysis of DNA, RNA and protein from other complex tissues.
Supplementary Figure 3 from Focal Adhesion Kinase Promotes the Aggressive Melanoma Phenotype (2023)

Supplementary Figure 3 from Focal Adhesion Kinase Promotes the Aggressive Melanoma Phenotype
ChemInform Abstract: Novel A‐Ring Modified Camptothecins as Topoisomerase I Inhibitors. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Imaging muscle as a potential biomarker of denervation in motor neuron disease (2017)

Whole-body muscle MRI offers a new approach to objective assessment of denervation over short timescales in MND and enables investigation of patterns of disease spread in vivo. Muscles inaccessible to conventional clinical and electrophysiological assessment may be investigated using this methodology.
P3–267: Loss of C5L2, an anti–inflammatory complement receptor in AD frontal cortex (2006)

Loss of cortical noradrenergic (NA) innervation occurs early in Alzheimer's disease (AD) due to loss of neurons in the locus ceruleus (LC). Destruction of the LC in transgenic AD mice increases glial inflammation and plaque deposition with increased behavioral decrements. Gene discovery experiments in rodents depleted of LC–mediated NA input were utilized to identify possible anti–inflammatory candidate proteins that might mediate these effects. These studies revealed a NA–regulated protein, termed DST11, with sequence homology to the G–protein coupled receptor superfamily. Western blot analysis of frontal cortex (Brodman 10, 11, 12) from AD postmortem brain and age–matched controls with a polyclonal antibody to DST11 revealed a 40% decrease of DST11 expression in AD brain (p<0.02). Sequence homology suggests that this protein may be the rat homologue of the human anaphylatoxin receptor C5L2 (Complement 5a–like receptor 2). To determine whether the NA–regulated protein DST11, decreased in the frontal cortex of AD brain, was indeed the human C5L2 receptor. Previously, whole cell preparations from human postmortem AD brain and age–matched controls were subjected to Western blot analysis. Incubation with a polyclonal antibody to DST11 revealed an approximately 50kDa band that was significantly decreased in AD brain. To determine whether the protein recognized by the DST11 antibody was indeed hC5L2, immunoprecipitation experiments were performed. Whole cell preparations were subjected to immunoprecipitation utilizing the original DST11 antibody. The immunopreciptitate was then subjected to Western blot and a polyclonal antibody for human C5L2 was utilized to detect immunoreactivity for C5L2. Western blot analysis of the protein immunoprecipitated with the DST11 polyclonal antibody revealed a band at approximately 50kDa recognized by the C5L2 antibody. Bands were quantified by NIH Image and subjected to a two–tailed t–test. Whole cell preparations from AD brain had 20% less C5L2 immunoreactivity than did age–matched controls (n=6, p=0.001). Underlying reasons for the magnitude differences between DST11 Western and DST11 immunopreciptiation/C5L2 immunoblot (40 vs 20%, respectively) have yet to be determined. Loss of NA–mediated innervation early in the progression of AD may precipitate loss of an anti–inflammatory complement receptor, C5L2 contributing to the inflammatory response in AD.
A new power grid optimization algorithm based on manufacturing cost restriction (2009)

Power grid optimization is required to minimize the risks of timing error by IR drop, defects by electro migration (EM), and manufacturing cost by the chip size. We propose a new approach by observing the direct objectives of manufacturing cost, and timing error risk. The optimization is executed in early phase of the physical design, and the purpose is to find the rough budget of decoupling capacitors that may cause block size increase. This approach enables selection of a cost sensitive result or a performance sensitive result.
Athena: Towards Decision-Centric Anticipatory Sensor Information Delivery (2018)

The paper introduces a new direction in quality-of-service-aware networked sensing that designs communication protocols and scheduling policies for data delivery that are optimized specifically for decision needs. The work complements present decision monitoring and support tools and falls in the larger framework of decision-driven resource management. A hallmark of the new protocols is that they are aware of the inference structure used to arrive at decisions (from logical predicates), as well as the data (and data quality) that need to be furnished to successfully evaluate the unknowns on which these decisions are based. Such protocols can therefore anticipate and deliver precisely the right data, at the right level of quality, from the right sources, at the right time, to enable valid and timely decisions at minimum cost to the underlying network. This paper presents the decision model used and the protocol design philosophy, reviews the key recent results and describes a novel system, called Athena, that is the first to embody the aforementioned data delivery paradigm. Evaluation results are presented that compare the performance of decision-centric anticipatory information delivery to several baselines, demonstrating its various advantages in terms of decision timeliness, validity and network resources used. The paper concludes with a discussion of remaining future challenges in this emerging area.
Common-Sense Psychology and Scientific Psychology (1992)

A revolution in the science of emotion has emerged in recent decades, with the potential to create a paradigm shift in decision theories. The research reveals that emotions constitute potent, pervasive, predictable, sometimes harmful and sometimes ...Read More
Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes (2011)

Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease resulting in the destruction of the insulin-secreting β cells. Currently, there is no established clinical approach to effectively suppress long-term the diabetogenic response. Genetic-based vaccination offers a general strategy to reestablish β-cell specific tolerance within the T-cell compartment. The transfer of genes encoding β-cell autoantigens, anti-inflammatory cytokines and/or immunomodulatory proteins has proven to be effective at preventing and suppressing the diabetogenic response in animal models of T1D. The current review will discuss genetic approaches to prevent and treat T1D with an emphasis on plasmid DNA- and adeno-associated virus-based vaccines.
A highly integrated single chip 5&#x2013;6 GHz front-end IC based on SiGe BiCMOS that enhances 802.11ac WLAN radio front-end designs (2015)

A highly integrated 4.9-5.9 GHz single chip front-end IC (FEIC) is presented, which is based on SiGe BiCMOS, realized in a 1.6 mm2 chip area and in an ultra-compact 1.7 × 2.0 × 0.33 mm3 package. The Tx chain has >30 dB gain and meets -40 dB DEVM up to Pout of 15 dBm and -35 dB DEVM up to Pout of 17 dBm with a 3.3 V supply, insensitive to modulation bandwidths and duty cycle. The ultra-low back-off DEVM enables the emerging 1024-QAM applications. The integrated log detector enhances the dynamic range for the transmit power control. The Rx chain features <;2.8 dB NF and 15 dB gain with 3 dBm IIP3 and 10 dB bypass attenuator with 23 dBm IIP3. All the unique features enhance the front-end circuit designs of complex radios based on the 802.11ac standard.
A synthetic bacterial information transfer system functions in the mammalian gut (2018)

Summary The gut microbiome is intricately involved with establishing and maintaining the health of the host. Engineering of gut microbes aims to add new functions and expand the scope of control over the gut microbiome. To create systems that can perform increasingly complex tasks in the gut with multiple engineered strains it is necessary to program communication among these bacteria in the gut. Towards this goal, we engineered an information transfer system for inter-cellular communication, using native gut Escherichia coli and attenuated Salmonella enterica serovar Typhimurium. Specifically, we have taken two genetic circuits-one for signaling from the quorum sensing system and the other for memory from the bacteriophage genetic switch–and integrated them into a robust system that can report on successful communication in the mammalian gut. Our system provides a basis for the construction of a programmable gut consortia as well as a basis for further understanding of bacterial interactions in an otherwise hard-to-study environment.
Phosphosilicate fiber: simple high-power cw 1.24- and 1.48-/spl mu/m Raman lasers (1998)

Summary form only given. The cascaded Raman fiber lasers pumped by Nd or Yb fiber lasers are effective tools for generating high-power cw radiation at wavelengths 1.24 and 1.48 /spl mu/m. However, germanosilicate fibers have a small Stokes frequency shift of 440 cm/sup -10/. This leads to the necessity of using the third and sixth Stokes orders to obtain the radiation with the wavelengths of 1.24 and 1.48 /spl mu/m correspondingly. Because of this, the structure of a cascaded Raman fiber laser consists of three and six pairs of Bragg gratings for 1.24 and 1.48 /spl mu/m. Besides the complexity and high cost of such cascaded Raman fiber lasers, the conversion efficiency is reduced with the growth of the Stokes order. The best option is a fiber with a large enough Stokes frequency shift to obtain 1.24 and 1.48 /spl mu/m radiation corresponding to Stokes lines of low order. A phosphosilicate fiber satisfies this requirement.
Marine Vibrators And The Doppler Effect (1988)

ABSTRACT Marine seismic data acquired with a moving vibrator suffer phase dispersion caused by Doppler shifting of the source sweep function. The dispersion, which can be as large as several hundred degrees, is a function of frequency, ship speed, sweep type, and the time dips of reflection events. In a constant-offset section, the Doppler factor for an event is the product of ship speed and the event's time dip. That key relationship allows the derivation of a two-dimensional filter that removes Doppler phase dispersion from seismic data. Both synthetic data and a Gulf of Mexico test line show that the phase-correcting filter is required for accurate steep-dip imaging with a moving vibrator source. INTRODUCTION Interest in marine vibrators has increased recently within the industry (Houston, 1987; Baeten, Fokkema, and Ziolkowski, 1987; O'Brien, 1986; Haldorsen, Desler, and Chu, 1985); and, in fact, a few seismic marine crews presently have the capability to acquire production lines with vibrator sources. Nevertheless, marine vibrators are still widely viewed as being exotic, experimental devices. As yet, they are not even close to having the industry-wide acceptance enjoyed by their land counterparts. One reason for this is that marine vibrators have a peculiar disadvantage not suffered by either impulsive marine sources or land vibrators: Doppler phase dispersion. In the usual production mode of marine operations, the seismic ship, the source, and the receivers move continuously through the water as data are recorded. Because of that motion, a correlated marine vibrator wavelet can contain phase dispersion due to classical Doppler frequency shifting. The size of the Doppler effect in any particular situation is proportional to the ratio of the speed of the motion (about 5 knots, or 2.6 m/s for a seismic ship) to the speed of sound in the surrounding medium (about 1500 m/s for water). Since, here, that ratio is small (about 0.0017), one might conclude at first that the Doppler effect is not important in marine vibrator data. The first of the two theory sections of this paper shows that conclusion to be, unfortunately, wrong. Phase dispersion as large as several hundred degrees can be observed at frequencies well within the seismic band. The second theory section proves the key result of this paper: when viewed in constant-offset gathers, phase dispersion caused by the Doppler effect is a function of only the apparent time dip of the reflection events, the type of vibrator pilot sweep, and the speed of the seismic ship. That result leads to a solution of the phase dispersion problem - a two-dimensional, phase-correcting filter that is applied in the frequency wavenumber domain. The performance of the phase-correction algorithm is demonstrated by applying it to some synthetic data that contain known Doppler effects. Finally, the filter is applied to field data from the Gulf of Mexico that show clear-cut examples of Doppler phase dispersion in the steeper reflections. The filter removes the phase dispersion.
Study of a Waveguide Antenna Implemented in Laminated Material (2002)

This document presents the investigation of a novel end-fire antenna implemented in laminated material. This study is related to the development of a phased array for the AEHF Military Satellite Communication Systems. This work includes theoretical analysis, computation of the developed models and measurement of the realised prototypes at 20.7GHz. The antenna element consists of a radiating rectangular waveguide. As a laminated dielectric material, like LTCC material, is supporting the antenna, the vertical walls need to be formed with vias of specific pitch. An effective coaxial-to-waveguide transition has also been developed to feed the radiating element. The results show that this laminated waveguide can be used as an integrated radiating element in the AEHF band for military satellite communications. A five-element array has also been prototyped. Although the results show low mutual coupling between the elements, additional work needs to be carried out to improve the array radiation characteristics.
Changes in dietary inflammatory potential predict changes in sleep quality metrics, but not sleep duration (2020)

NCT02382458.
The Synthesis and Structural Characterization of the Sterically Demanding Tris (3,5-di-t-butylpyrazolyl) hydroborato Ligand, [TpBut2]: A Highly Twisted, Propeller-Like, Ligand System (1995)

The synthesis of the new sterically demanding tris (3,5-di-t-butylpyrazolyl) hydroborato ligand, [TpBu2 t ], in which both the 3- and 5-positions of the pyrazolyl group are occupied by bulky t-butyl substituents is described. The structural character
Interleaved buck converter having low switching losses and improved step-down conversion ratio (2011)

A new interleaved buck converter (IBC) having low switching losses and improved step-down conversion ratio is proposed in this paper. It is similar to a conventional IBC, but two active switches are connected in series, and a coupling capacitor is employed in the power path, like Cuk, Sepic, and Zeta converters. The proposed IBC shows that since the voltage stress across all active switches is half of the input voltage before turn-on or after turn-off, the capacitive discharging and switching losses can be reduced considerably. This allows the proposed IBC to have higher efficiency and be operated at higher switching frequency. In addition, the proposed IBC has higher step-down conversion ratio and smaller output current ripple than a conventional IBC. The features, operation principles, and relevant analysis results of the proposed IBC are presented in this paper. The validity of this study is confirmed by the experimental results of prototype converters with 150-200V input, 24V/10A output.
Prognostic factors for patients with advanced renal cell carcinoma (aRCC) in the era of first-line (1L) treatment with immune checkpoint inhibitors (ICIs). (2022)

4544 Background: The most commonly used prognostic models in aRCC, the Memorial Sloan-Kettering Cancer Center (MSKCC) and the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk scores, were developed when cytokines and VEGF targeted monotherapies were standard of care, respectively. aRCC 1L treatment now includes combination therapy with 2 ICIs or ICI+VEGF receptor inhibitor. Re-evaluation of the MSKCC and IMDC prognostic models in the era of ICI therapy and identification of additional prognostic factors are overdue. Methods: Data from 1052 patients with aRCC treated on the CheckMate-214 (CM214) clinical trial with 1L nivolumab/ipilimumab (NIVO/IPI) or sunitinib (SUN) were analyzed retrospectively at median follow-up 5 yrs. For each treatment group, multivariable Cox model hazard ratios (HR) were compared to the published MSKCC and IMDC model HRs. Discrimination (c index) was assessed based upon the continuous scores obtained as the weighted combination of regression parameters from the published MSKCC &amp; IMDC models. Results: KPS &lt; 80% remained highly prognostic in both treatment groups (HRs &gt; 2.5). With the exception of high calcium, the other factors of time from dx to treatment &lt; 1 yr, hemoglobin &lt; lower limit of normal (LLN), neutrophils &gt; upper limit of normal (ULN), platelets &gt; ULN and LDH &gt; 1.5xULN consistently retained prognostic value for SUN (HRs ≥ published model HRs) but had diminished prognostic value for NIVO/IPI (each HR &lt; published model HR). High calcium had diminished prognostic value for SUN and retained prognostic value for NIVO/IPI. The c-indices for discrimination were 0.61 and 0.64 for the MSKCC model in the NIVO/IPI and SUN treatment groups, respectively, and were 0.63 and 0.67 for the IMDC model in the NIVO/IPI and SUN treatment groups compared to reported IMDC c-index of 0.73 (Heng 2009). (Table) Conclusions: The prognostic ability of the MSKCC and IMDC risk models is reduced with combination ICI treatment. Evaluation of additional prognostic factors and development of new risk scores are needed and this work is ongoing. [Table: see text]
Architecture and Implementation of a Scalable Sensor Data Storage and Analysis System Using Cloud Computing and Big Data Technologies (2015)

Sensors are becoming ubiquitous. From almost any type of industrial applications to intelligent vehicles, smart city applications, and healthcare applications, we see a steady growth of the usage of various types of sensors. The rate of increase in the amount of data produced by these sensors is much more dramatic since sensors usually continuously produce data. It becomes crucial for these data to be stored for future reference and to be analyzed for finding valuable information, such as fault diagnosis information. In this paper we describe a scalable and distributed architecture for sensor data collection, storage, and analysis. The system uses several open source technologies and runs on a cluster of virtual servers. We use GPS sensors as data source and run machine-learning algorithms for data analysis.
Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex (2004)

Visual recognition memory is subserved by a distributed set of neural circuits, which include structures of the temporal lobe. Conflicting experimental results regarding the role of the hippocampus in nonspatial forms of such memories have been attributed to species, task, and lesion discrepancies. We have overcome obstacles that have prevented a direct evaluation of the role of the hippocampus in this type of memory by developing for rats a nonspatial, picture-based, trial-unique, delayed matching-to-sample task that is a procedural analogue of standard visual recognition memory tasks used in primates. With this task, we demonstrate that rats have a visual memory profile, which is analogous to that in primates and depends on the function of perirhinal cortex. We also find that selective lesions of hippocampus impair delay-dependent visual memory with a profile different from that produced by damage to the perirhinal cortex. These data demonstrate that rats have a visual recognition memory system fundamentally similar to primates that depends on the function of the hippocampus.