gebhart/patrepeval huggingface dataset:
Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin (2009)

Repetitive strain stimulates intestinal epithelial migration across fibronectin via focal adhesion kinase (FAK), Src, and extracellular signal-related kinase (ERK) although how these signals act and interact remains unclear. We hypothesized that PI3K is central to this pathway. We subjected Caco-2 and intestinal epithelial cell-6 cells to 10 cycles/min deformation on flexible fibronectin-coated membranes, assayed migration by wound closure, and signaling by immunoblots. Strain stimulated PI3K, AKT, glycogen synthase kinase (GSK), and p38 phosphorylation. Blocking each kinase prevented strain stimulation of migration. Blocking PI3K prevented strain-stimulated ERK and p38 phosphorylation. Blocking AKT did not. Downstream, blocking PI3K, AKT, or ERK inhibited strain-induced GSK-Ser9 phosphorylation. Upstream of AKT, reducing FAK or Rac1 by siRNA blocked strain-stimulated AKT phosphorylation, but inhibiting Src by PP2 or siRNA did not. Transfection with FAK point mutants at Tyr397, Tyr576/577, or Tyr925 demonstrated that only FAK925 phosphorylation is required for strain-stimulated AKT phosphorylation. Myosin light chain activation by strain required FAK, Rac1, PI3K, AKT, GSK, and ERK but not Src or p38. Finally, blebbistatin, a nonmuscle myosin II inhibitor, blocked the motogenic effect of strain downstream of myosin light chain. Thus strain stimulates intestinal epithelial migration across fibronectin by a complex pathway including Src, FAK, Rac1, PI3K, AKT, GSK, ERK, p38, myosin light chain, and myosin II.
Patient-Centered Technological Assessment and Monitoring of Depression for Low-Income Patients (2014)

Depression is a significant challenge for ambulatory care because it worsens health status and outcomes, increases health care utilizations and costs, and elevates suicide risk. An automatic telephonic assessment (ATA) system that links with tasks and alerts to providers may improve quality of depression care and increase provider productivity. We used ATA system in a trial to assess and monitor depressive symptoms of 444 safety-net primary care patients with diabetes. We assessed system properties, evaluated preliminary clinical outcomes, and estimated cost savings. The ATA system is feasible, reliable, valid, safe, and likely cost-effective for depression screening and monitoring for low-income primary care population.
Abstract 2303: Innate immunity driving tumor angiogenesis: the role of natural killer cells in non small cell lung cancer (NSCLC) . (2013)

Abstract Immune cells infiltrating tumors often show a skewed phenotype that reflects attenuation of anti-tumor activity and enhancement of pro-tumor activities, including angiogenesis. Natural Killer (NK) cells are effectors lymphocytes of innate immunity that can potentially control tumors by their cytotoxic activity. Nevetherless the role of NK cells in angiogenesis remains to be defined. Here we investigate the subset distribution of tumor infiltrating NKs and the correlation with pro-angiogenic factor production, like VEGF, PlGF and IL-8, on clinical samples belonging from patient with non-small cell lung cancer (NSCLC). Samples (tumor, adjacent normal tissue and peripheral blood), solid tissues are mechanically dispersed, while blood is processed using a Ficoll gradient. Flow cytometry (FC) analyses were performed to evaluate specific markers (CD56, CD16, CD335, CD3) for NK cells. The CD56brightCD16−NK phenotype predominated in all NSCLC samples while the CD56dimCD16+ cytotoxic NK phenotype prevailed in adjacent normal tissues and in non-oncologic lung tissues, independent of smoking status. The CD56+CD16− NK subset was associated with angiogenic cytokines production like VEGF, PlGF and IL-8 (CXCL8) Further, patients with the SQK histotype showed significantly higher angiogenic factor production by CD56+CD16−NK cells infiltrating tumors, adjacent tissues and peripheral blood, compared to those from adenocarcinoma (ADK) and control tissues. Supernatants derived from NSCLC infiltrating CD56+CD16−NK cells induced endothelial cell chemotaxis and formation of capillary-like structures in vitro, particularly evident in SQK derived NK cell supernatants and absent in controls As TGFβ1 expression has been associated with poorer survival in non-small cell lung cancer (NSCLC) squamous cell carcinoma (SQK) and polarization of peripheral NK cells towards a decidual NK phenotype, a subset associated with angiogenesis, we evaluated whether TGFb culd be implicated in these polarization phenomena. We demonstrated as exposure to TGFβ1 up-regulated VEGF and PlGF production by peripheral blood CD56+CD16−NK cells from healthy subjects. Our data suggest that, like other immune cells, NK cells in NSCLC can be switched to an angiogenic phenotype, particularly evident for SQK and likely mediated by TGFβ1, which could contribute to angiogenesis in SQK NSCLC development and progression. Citation Format: Adriana Albini, Antonino Bruno, Arianna Pagani, Andrea Imperatori, Marco Spagnoletti, Nicola Rotolo, AnnaRita Cantelmo, Francesca Franzi, Carlo Capella, Guido Ferlazzo, Lorenzo Mortara, Douglas M. Noonan. Innate immunity driving tumor angiogenesis: the role of natural killer cells in non small cell lung cancer (NSCLC) . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2303. doi:10.1158/1538-7445.AM2013-2303
CSIG-02. MOLECULAR PROFILING IDENTIFIES INCREASED TRANSGELIN-2 EXPRESSION IN LOW(ER) GRADE GLIOMAS WITH WILD-TYPE IDH1/2 VS. MUTANT IDH1/2 (2017)

Low(er) grade gliomas (LGGs) exhibit variable prognoses and responses to chemotherapy and radiation. While gliomas were traditionally categorized by histopathological features, the World Health Organization revised the classification system by integrating prognostic molecular biomarkers, including isocitrate dehydrogenase (IDH)1/2 mutations. LGGs with mutant (MT)-IDH have improved prognosis compared to wild-type (WT) LGGs. Therefore, we aimed to elucidate signaling mechanisms governing differences in clinical response by mRNA profiling. The Affymetrix ClariomD array and LIMMA analysis identified genes differentially expressed in Mut-IDH vs. WT-IDH in grade II (n=19) and grade III (n=38) gliomas from our cohort and data were compared with the TCGA. In vitro functional studies confirmed roles in invasion and proliferation. Our analysis identified 343 probesets with significant differential gene expression in Mut-IDH vs. WT-IDH gliomas (FDR p-value<0.1). Among these genes, we identified transgelin-2, an actin-polymerizing gene, associated with poor prognosis and increased tumor growth and invasion in cancer. However, its role in gliomas has not yet been reported. Transgelin-2 mRNA (FDR p-value<0.1) and protein (FDR p-value<0.05) were heightened in WT vs. Mut-IDH in our LGG cohort. Transgelin-2 mRNA was also significantly higher in WT-IDH gliomas in the TCGA cohort (FDR<0.05). Interestingly, there was significantly greater transgelin-2 promoter methylation in LGGs with Mut- vs. WT-IDH (FDR p<0.05) in both cohorts. Transgelin-2 was also associated with poor prognosis in both the TCGA (HR 2.6, p=3.1x10-5) and our (HR 3.74, p=0.079) cohorts. Our in vitro studies confirmed that knock-down of transgelin-2 decreased proliferation and invasion of glioma cells. Our study suggests that transgelin-2 may contribute to proliferation and invasion and may serve as a potential prognostic biomarker in WT-IDH1/2 LGGs. Future studies will evaluate transgelin-2 as a novel therapeutic target and predictive biomarker contributing to chemoradiation resistance in gliomas. FUNDING: R01CA108633, R01CA169368, RC2CA148190, U10CA180850-01, BTFC, OSU-CCC (all to AC).
A Soft Approach to Encapsulate Sulfur: Polyaniline Nanotubes for Lithium‐Sulfur Batteries with Long Cycle Life (2012)

A novel vulcanized polyaniline nanotube/sulfur composite was prepared successfully via an in situ vulcanization process by heating a mixture of polyaniline nanotube and sulfur at 280 °C. The electrode could retain a discharge capacity of 837 mAh g(-1) after 100 cycles at a 0.1 C rate and manifested 76% capacity retention up to 500 cycles at a 1 C rate.
Real-Time Feature Extraction From Electrocochleography With Impedance Measurements During Cochlear Implantation Using Linear State-Space Models (2023)

Electrocochleography (ECochG) is increasingly used to monitor the inner ear function of cochlear implant (CI) patients during surgery. Current ECochG-based trauma detection shows low sensitivity and specificity and depends on visual analysis by experts. Trauma detection could be improved by including electric impedance data recorded simultaneously with the ECochG. However, combined recordings are rarely used because the impedance measurements produce artifacts in the ECochG. In this study, we propose a framework for automated real-time analysis of intraoperative ECochG signals using Autonomous Linear State-Space Models (ALSSMs). We developed ALSSM based algorithms for noise reduction, artifact removal, and feature extraction in ECochG. Feature extraction includes local amplitude and phase estimations and a confidence metric over the presence of a physiological response in a recording. We tested the algorithms in a controlled sensitivity analysis using simulations and validated them with real patient data recorded during surgeries. The results from simulation data show that the ALSSM method provides improved accuracy in the amplitude estimation together with a more robust confidence metric of ECochG signals compared to the state-of-the-art methods based on the fast Fourier transform (FFT). Tests with patient data showed promising clinical applicability and consistency with the findings from the simulations. We showed that ALSSMs are a valid tool for real-time analysis of ECochG recordings. Removal of artifacts using ALSSMs enables simultaneous recording of ECochG and impedance data. The proposed feature extraction method provides the means to automate the assessment of ECochG. Further validation of the algorithms in clinical data is needed.
Execution plan balancing (2002)

A novel relational query optimization technique for use in shared memory multiprocessor database systems is described. A collection of practical algorithms for allocating computational resources to parallel select-project filter (SPJ) query execution plans is presented. The computational resources considered include disk bandwidth, memory buffers and general-purpose processors. The goal of the allocation algorithms is to produce minimum duration execution strategies with computational resource requirements that are less than the given system bounds. Preliminary experimental results indicate that the algorithms can be realized and are effective in producing good execution plans. Disk bandwidth appears to be the critical system resource. The most effective means to decrease complex query response time appears to be by reducing disk contention. This can be achieved by increasing the total number of disks and/or rearranging the placement of data on disks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figures 1 - 7 from Th-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis (2023)

&lt;p&gt;PDF file - 709K, Figure S1. Correlation of relative mean fold changes in expression of genes and microRNAs of the mouse tumor groups by expression- array and by quantitative RT-PCR. Figure S2. Levels of caspase-8 protein in primary tumors and BM secondary tumors. Figure S3. Primary tumors from wild-type or caspase-8 deficient (fl/ko, fl/fl or wt/ko caspase-8) mice had neuroblastoma morphology and stained positive for neuronal markers typical for neuroblastoma. Figure S4. Age at maximum tumor burden of neuroblastoma primary tumors in the Th-MYCN mouse groups. Figure S5. Measuring apoptosis levels by immunostaining for cleaved caspase-3. Figure S6. MYCN expression in the primary Th-MYCN, Th-Cre neuroblastoma tumors. Figure S7. Secondary tumors observed in both the Th-MYCN Caspase-8 wt/wt and the Th-MYCN deficient caspase-8 mouse models.&lt;/p&gt;
Search for New Hypoglycemic Agents. Part III. Biguanide Derived from 1,3,4-Oxadiazoles and Thiazoles (1976)

Department of Chemistry, Lucknow University, Lucknow. <em>Manuscript received 22 September 1975; accepted 25 October 1975.</em> Several N-(5-alkyl or aryl-1, 3, 4-oxadiazol-2-yl)-and. N-(4, 5-substituted-thiazol-2-yl)-biguanides have been synthesised to examine their hypoglycemic activity. A slight reduction In blood sugar level was observed when five of these compounds were screened on rats.
ChemInform Abstract: PREPARATION AND REACTION OF N‐(P‐TOLYLSULFONYL)SULFILIMINES (1979)

Abstract Aus den Sulfiden (I) erhält man mit Chloramin T (II) unter Phasen‐Transfer‐Katalyse in Gegenwart von z.B. Tributylhe xadecylammoniumbromid die Sulfilimine (III), die in Tabellen beschrieben werden.
Magnetic pulse welding on the cutting edge of industrial applications (2014)

Magnetic Pulse Welding (MPW) applies the electromagnetic principles postulated in the XIXth century and later demonstrated. In recent years the process has been developed to meet highly demanding market needs involving dissimilar material joining, specially involving difficult-to-weld materials. It is a very high speed joining process that uses an electromagnetic force to accelerate one material against the other, resulting in a solid state weld with no external heat source and no thermal distortions. A high power source, the capacitor, a discharge switch and a coil constitute the minimum equipment necessary for this process. A high intensity current flowing through a coil near an electrically conductive material, locally produce an intense magnetic field that generates eddy currents in the flyer according to Lenz law. The induced electromotive force gives rise to a current whose magnetic field opposes the original change in magnetic flux. The effect of this secondary current moving in the primary magnetic field is the generation of a Lorentz force, which accelerates the flyer at a very high speed. If a piece of material is placed in the trajectory of the flyer, the impact will produce an atomic bond in a solid state weld. This paper discusses the fundamentals of the process in terms of phenomenology and analytical modeling and numerical simulation. Recent industrial applications are presented in terms of materials, joint configurations and real examples as well as advantages and disadvantages of the process.
Uses of antisense nucleic acids — an introduction (1992)

Conference Article| November 01 1992 Uses of antisense nucleic acids — an introduction Alan D. B. Malcolm Alan D. B. Malcolm 1Department of Biochemistry, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: July 24 1992 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1992 Biochemical Society1992 Biochem Soc Trans (1992) 20 (4): 745–746. https://doi.org/10.1042/bst0200745 Article history Received: July 24 1992 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Alan D. B. Malcolm; Uses of antisense nucleic acids — an introduction. Biochem Soc Trans 1 November 1992; 20 (4): 745–746. doi: https://doi.org/10.1042/bst0200745 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: ODN, oligodeoxynucleotide This content is only available as a PDF. © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
Data Supplement from Temozolomide Induces the Production of Epidermal Growth Factor to Regulate <i>MDR1</i> Expression in Glioblastoma Cells (2023)

&lt;p&gt;Figure S1. The band densities for the western blot for P-gp in Fig. 1D were normalized to β-actin. The data are presented as fold expression for both cell lines, three different experiments. Figure S2. The band densities for cJun/Fos and p-cJun/Fos in the western blots with U87 extracts in Fig. 4B were normalized to β-actin and then presented as Fold Expression, three different experiments. Figure S3. The band densities for cJun/Fos and p-cJun/Fos in the western blots with T98G extracts in Fig. 4B were normalized to β-actin and then presented as Fold Expression, three different experiments. Figure S4. Bands shown for the western blots for P-gp in Fig. 5C were normalized band with the bands for β-actin. The results are expressed as fold expression, three different experiments.&lt;/p&gt;
[Immediate breast reconstruction and postoperative radiotherapy: an overview]. (2011)

Breast reconstruction is nowadays integral part of the treatment of breast cancer. When it is proposed as an immediate reconstruction, the plastic surgeon has to deal with several constraints. The coverage of the patients that must benefit from a mastectomy is complicated by additional treatments of radiotherapy. We propose, in this work, a multidisciplinary splitting of the patients into specific subgroups. An immediate reconstruction will be proposed to certain patients considering the adjuvant radiotherapy. The choices of orientation are complex and a scarce literature on this subject does not allow us to guide in a systematic way all the patients. More studies, with a prospective design, are necessary to guide the patients wishing an immediate reconstruction associated with a radiotherapy after mastectomy.
Synthesis and characterizations of NaFePO4/Na2FePO4Fcathode materials for Na-ION based AQUEOUS battery (2014)

Rechargeable Li-ion batteries have dominated the market for twenty years. However,&#13;\nthe increasing demand for energy storage creates new challenges for further use of lithium-ion batteries&#13;\nmainly due to the problems associated with lithium sources and safety issues [1]. Na-ion based battery is an&#13;\nappealing alternative with comparable energy density to Li-ion based technologies [2]. Moreover, the fast&#13;\nion intercalation/deintercalation in the aqueous electrolyte media could allow for the operations under high&#13;\nelectric current conditions required especially for high power supply and eliminate safety issue [3].
Supplemental calcium and vitamin D and long-term mortality in aortic stenosis (2022)

Supplemental calcium with or without vitamin D is associated with lower survival and greater AVR in elderly patients with mild-moderate AS.
Pulsed-duty characterization of turn-off for a population of SCRs and the effect of variation on equalization circuit design (2003)

Turn-off characteristics of silicon-controlled rectifiers (SCRs) drive the design of snubber circuits for single devices in power converters. Turn-off characteristics also drive the design of equalization circuits for series-connected devices in power converters. For single devices, the important characteristics are peak recovery current, recovery time, and recovered charge. These characteristics are also important for series-connected devices, but it is the variation in these characteristics that define the equalization requirements. In fact, these variations are used to determine the size and power dissipation of the equalization circuit. A population of SPCO 402b pulse-rated silicon controlled rectifiers was tested and recovery characteristics were measured. The differences in recovery characteristics were tabulated and discussed. A method of equalization circuit design based on circuit variations was discussed and circuit design trades are made in light of the variations in recovery characteristics.
The ABO and Lewis Blood-Group System (1969)

DESPITE the recognized importance of the ABO and Lewis antigens in blood typing and transfusion, few physicians appreciate the extraordinary complexity of this system and its association with human disease. These antigens are found in secretions throughout the body and on the surface of epithelial and endothelial cells. Current interest in kidney transplantation has directed attention to their presence in the renal vascular endothelium. ABO incompatibility between mother and fetus may produce infertility or hemolytic disease of the newborn, and persons of certain blood groups have an increased susceptibility to peptic ulcer or gastric cancer. The purpose of this review . . .
Identification of phlebotomine sand flies using one MALDI-TOF MS reference database and two mass spectrometer systems (2015)

A centralized high-quality database (created by expert taxonomists and experienced users of mass spectrometers) that is easily amenable to customer-oriented identification services is a highly desirable resource. As shown in the present work, spectra obtained from different specimens with different instruments can be analysed using a centralized database, which should be available in the near future via an online platform in a cost-efficient manner.
A New Hybrid Phosphine Ligand for Palladium‐Catalyzed Amination of Aryl Halides (2008)

Abstract A new hybrid phosphine was designed. The phosphine combines two common structural characteristics found among the effective phosphine ligands reported recently, namely, three tert ‐alkyl substituents binding to the phosphorus and an aryl group at an appropriate position. A hybrid phospine/palladium system is versatile and effective for the coupling reaction of various aryl halides with primary and secondary amines including carbazole.
Multimodal transformed social interaction (2004)

Understanding human-human interaction is fundamental to the long-term pursuit of powerful and natural multimodal interfaces. Nonverbal communication, including body posture, gesture, facial expression, and eye gaze, is an important aspect of human-human interaction. We introduce a paradigm for studying multimodal and nonverbal communication in collaborative virtual environments (CVEs) called Transformed Social Interaction (TSI), in which a user's visual representation is rendered in a way that strategically filters selected communication behaviors in order to change the nature of a social interaction. To achieve this, TSI must employ technology to detect, recognize, and manipulate behaviors of interest, such as facial expressions, gestures, and eye gaze. In [13] we presented a TSI experiment called <i>non-zero-sum gaze</i> (NZSG) to determine the effect of manipulated eye gaze on persuasion in a small group setting. Eye gaze was manipulated so that each participant in a three-person CVE received eye gaze from a presenter that was normal, less than normal, or greater than normal. We review this experiment and discuss the implications of TSI for multimodal interfaces.