gebhart/patrepeval huggingface dataset:
Smart Design System for Coal-Fired Boiler Buildings in Thermal Power Plants (2008)

To meet expanding energy requirements, supercritical sliding pressure operation has become a major trend in recent thermal power plants. The technology for this operation was developed as high efficient thermal power plants with lower emission. We have continued to develop supercritical steam plant with sliding pressure operation to meet the demand for high efficiency coal-fired power plants that has arisen due to circumstances such as high fuel prices, exacting plant site requirements, and very strict environmental requirements. Because of our accumulated expertise and practical experience, we have received orders for several coal-fired engineering, procurement, and construction (EPC) projects. We have developed a smart design system for a coal-fired boiler building using an information technology (IT) tool for a large-scale and complex system design. We call this design system the Flexible Engineering System. This system is composed of three support functions: boiler general arrangement, boiler building layout, and bill of quantity estimation. First, the boiler general arrangement support function enables us to automatically create basic engineering specifications based on the required specifications. This system generates the basic engineering required using parametric engineering practice with parameterization of several required specifications. Second, the support function of the boiler building layout planning enables us to make 3-D models of the boiler building automatically. The 3-D models of the boiler, coal silos, and air and gas ducts are generated from the boiler general arrangement. The 3-D models of the steel structures are generated from loading data. The steel structure and brace models can even reflect the results of stress analysis. The 3-D models of large components, for example, the pulverizer, forced draft fan, etc., are arranged by selecting a matching model from the data library. The 3-D piping models are generated along the optimum path routing using a search method that combines dynamic programming with a layout rule-base. The 3-D floor and head-clearance model, which means a walk space and a maintenance space, are generated taking into consideration layout rules such as those concerning installation and maintenance. This support system can check for interference between the steel structures and each component. Third, the support function of the bill of quantity estimation makes it possible to estimate the quantity of materials from the specification data and configuration data of the 3-D models. The developed system is now under operation. The results indicate that it provides high engineering accuracy and reliability.
The new lymphotropic herpesviruses (HHV-6, HHV-7, HHV-8) and hepatitis C virus (HCV) in human lymphoproliferative diseases: an overview. (1996)

Considerable evidence has been accumulating in favor of a possible involvement of viral agents in the pathogenesis of human lymphomas. The most recent proposal for a lymphoma classification, the Revised European-American Classification, emphasized for the first time the pathogenetic importance of two viruses, namely Epstein-Barr virus (EBV) and human T lymphotropic virus I (HTLV-I) in the development of certain lymphoid neoplasias. However, in the last ten years new viral agents possibly related to lymphoproliferative activity have been discovered: three herpesviruses [human herpesvirus-6 (HHV-6), -7 (HHV-7) and -8 (HHV-8)] and a flavivirus, HCV. HHV-6 was isolated from the peripheral blood of patients with lymphomas and a possible role for this beta-herpesvirus in Hodgkin's disease and in angioimmunoblastic lymphadenopathy (AILD) has emerged from serological and molecular studies. HHV-7, a beta-herpesvirus genetically close to HHV-6, has not yet been found in a human disease but it utilizes CD4 as a receptor on the lymphocyte surface. Only partial HHV-8 genomic sequences have been identified so far, suggesting a genetic homology with members of the gamma-herpesvirus family, including EBV. HHV-8 sequences have been identified for the first time in all forms of Kaposi's sarcoma as well as in a variety of lymphoid disorders, including body-cavity-based non Hodgkin's lymphomas, Castleman's disease, AILD and a type of HIV-negative reactive lymphadenopathy with peculiar histologic features. Finally, after its identification as the major cause of post-transfusion and sporadic non-A, non-B hepatitis, HCV has revealed a lymphotropism both in vitro and in vivo. A strong association between HCV infection and a benign lymphoproliferative disease, essential mixed cryoglobulinemia type II, has clearly emerged both from serological and molecular studies. A possible role for this viral infection in B-cell non Hodgkin's lymphomas not associated with cryoglobulinemia has also been proposed recently. The present work offers an overview of the huge amount of experimental and clinical observations supporting the possible involvement of these new lymphotropic viruses in human lymphoproliferative diseases.
Acute effect of amitriptyline, phenobarbital or cobaltous chloride on .DELTA.-aminolevulinic acid synthetase, heme oxygenase and microsomal heme content and drug metabolism in rat liver. (1989)

Cobaltous chloride (CoCl2) caused very marked decreases of cytochrome P-450, b5 and total heme contents and an increase of heme oxygenase activity. On the contrary, phenobarbital (PB) increased hepatic drug-metabolizing enzymes, but the total heme content remained unchanged. On the other hand, amitriptyline (AMT) caused a marked increase of delta-aminolevulinic acid (delta-ALA) synthetase activity at 12 and 24 hr. In addition, the contents of total heme and cytochrome b5 and the activities of aminopyrine (AM) N-demethylase and aniline (AN) hydroxylase at 24 hr were also increased by AMT, whereas cytochrome P-450 content did not change. This may be explained by the fact that AMT would increase hepatic heme synthesis through the prolonged induction of delta-ALA synthetase, but it may not cause an increase in cytochrome P-450 heme because there are increases in the contents of cytochrome b5 and total heme.
Comparison of Ion-Exchange Resins and Biosorbents for the Removal of Heavy Metals from Plating Factory Wastewater (1997)

The NCP (Neurospora crassa gene expressed in the periplasmic space) is a recombinant Escherichia coli expressing the Neurospora crassa metallothionein gene within the periplasmic space. The NCP has been shown to remove heavy metals from solutions containing low concentration of heavy metals. In this study, the ability of NCP to remove heavy metals from wastewater was compared to the commercial sorbents Duolite GT-73, IRC-718, and BIO-FIX. Three process wastewater streams, acid/alkali, chromate, and cyanide, were tested at their original pH and near neutral pH. In addition to other contaminants, the wastewaters contained metals including Cd, Cu, Ni, and Ag. NCP was most efficient in removing the heavy metals from wastewaters at near neutral pH. Chromium removal per gram of IRC-718 at pH 2.05 was an order of magnitude higher than any other sorbent in either pH-unadjusted or pH-adjusted samples. Duolite GT-73, IRC-718, and BIO-FIX had similar efficiency in removing heavy metals from the pH-adjusted wastewater. When the sorbents were tested for removal of part per billion levels of 109Cd, NCP demonstrated the highest percent removal. These results suggest potential treatment strategies for metal-contaminated wastewaters involving pH adjustment and primary treatment with a commercial sorbent followed by polishing with NCP.
Note sur le Dewan Bahasa dan Pustaka de Brunei (1972)

(3) Three brief notes are devoted to the following: (a) to the Dewan Bahasa dan Pustaka of the Sultanat of Brunei, whose activities, parallel to those of the Dewan of Kuala Lumpur (cf Archipel 2, p. 23) concentrate above all on the publication of texts and lexicography, (b) to Sasterawan, a literary revue edited exclusively in Malay, whose first editions have just appeared in Singapore, (c) To Pustaka Djaya, a new publishing house that Ajip Rosidi has just started under the auspices of the Municipality of Djakarta, and whose aim is to give a taste of books and reading to a larger public.
Stable crosslinked gate electrodes for hygroscopic insulator OTFT sensors (2021)

We report methods for fabricating stable PEDOT:PSS gate electrodes for hygroscopic insulator field effect transistors for sensing applications. Crosslinkers DVS and GOPS are used, and the challenges and advantages of each are demonstrated.
Increased leucocyte adhesiveness/aggregation is a most useful indicator of disease activity in patients with inflammatory bowel disease. (1995)

The aim of the study was to determine the comparative usefulness of inflammatory markers, in evaluating disease activity in patients with inflammatory bowel disease. Disease activity was assessed by the Mayo Clinic score for ulcerative colitis, and Harvey-Bradshaw score for Crohn's disease. Five hundred normal blood donors who had no underlying inflammatory condition served as controls. The erythrocyte sedimentation rate, platelet and white blood cell count, C reactive protein, and the leucocyte adhesiveness/aggregation test (LAAT) were determined in each patient. One hundred and twenty four patients with inflammatory bowel disease were tested while in remission and 128 in relapse. Their mean (SD) per cent of aggregated white blood cells in the peripheral blood was 8 (5) and 17 (10) respectively compared with controls 6 (4) (p < 0.0001). Moreover, the LAAT could effectively discriminate between various grades of disease activity, the values in patients with active disease being 13 (6)% in mild, 17 (10)% in moderate, and 26 (10)% in severe disease (p < 0.0001). Other acute phase reactants including the erythrocyte sedimentation rate, the white blood cell count, the platelet count, neutrophil count, as well as, the C reactive protein concentration did not differentiate as well between the various groups. Using logistic regression analysis to differentiate between inflammatory bowel disease patients in remission or relapse, the LAAT was the single best indicator. The addition of any other test did not contribute to the discrimination. Among the different laboratory variables tested only the LAAT significantly discriminated between the five different subgroups of controls, remission and mild, moderate or severe disease activity.
ChemInform Abstract: AMINOMETHYLPSORALENS. ELECTROPHILIC SUBSTITUTION OF HYDROXYMETHYLPHTHALIMIDE ON LINEAR FUROCOUMARINS (1985)

Abstract Die Furocumarine (I) werden mit N‐Hydroxymethylphthalimid (II) unter sauren Bedingungen umgesetzt.
Psychiatric Manifestations of Olivo-Ponto-Cerebellar Atrophy and Treatment with Clozapine (1993)

Patients with multiple system atrophy, a neurodegenerative disease entity, have a high incidence of associated mental disturbances such as a mood disorder with or without psychotic features. Treatment of the psychiatric symptoms, without compromising neurological status, is often complicated and unsuccessful. This article describes a patient with olivo-ponto-cerebellar atrophy and treatment-resistant psychotic depression whose psychiatric symptoms were successfully treated with clozapine without aggravating the neurological disabilities.
Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia (2010)

The goal of this study was to identify genetic markers associated with LY2140023 monohydrate response in patients with schizophrenia. Variants in eight candidate genes related to the mechanism of action of LY2140023 or olanzapine were investigated in a genetic cohort collected from two clinical trials. Results from this genetic analysis indicate that 23 single nucleotide polymorphisms (SNPs) were associated with a change in Positive and Negative Syndrome Scale total score in response to LY2140023 at 28 days (P<0.01; false discovery rate <0.2). Sixteen of these SNPs were located in the serotonin 2A receptor (HTR2A). Bioinformatic analyses identified a putative antisense nested gene in intron 2 of HTR2A in the region of the genetic markers associated with LY2140023 response. These data suggest a genetic association exists between SNPs in several genes, such as HTR2A, and response to LY2140023 treatment. Additional clinical trials are needed to establish replication of these results.
The other formalization of law (1997)

me g.rowth of the Internet and of the Web space calls for a re-examination of some of the basis of computer information systems for the law. All the more since searching and publishing systems in the law field have known few changes in the last thirty years. In that context, the SGML-based Jirtemet publishing system developed for the decisions of the Supreme Court of Canada offers the opportunity of checking a number of hypothesis on the interest of SGML for the design of better information systems for the law. The project also sheds a light on possible contributions of SGML and AI techniques to each other.
Converting from distributed to lumped elements (2013)

A method for replacing transmission lines used in traditional microwave circuits with lumped inductor and capacitor components will be given. To demonstrate this, a Wilkinson power splitter was designed. These circuits were fabricated measured and tested. A significant circuit size reduction was demonstrated. The effects of the parasitics in the lumped element were also taken into consideration. This method is very useful when using microwave circuits in ICs or PCBs.
Using the monotone property and sensors placement as basic tools to design set-membership state estimators (2016)

International audience
Secrecy Enhancement via Public Discussion (2005)

(X, Y, Z) is an ensemble of independent random triples, each distributed according to some probability distribution p(x, y, z). Two legitimate users, Px having X and Py having Y, communicate in order to agree on a joint key while keeping it almost unknown to an eavesdropper Pz who knows Z. Communication is conducted over a noiseless channel according to a predetermined protocol. P2 hears all transmissions over the channel and knows the protocol used. We show: (1) The legitimate communicators can agree on the secret if and only if they can find one using just two messages. (2) There are cases where a secret can be found, but one message does not suffice. (3) Similar results hold whether the legitimate communicators are required to agree on the secret with probability one or just with high probability.
A MALDI-TOF MS-based discriminant model to distinguish azole-resistant Aspergillus fumigatus strains (2022)

Abstract Aspergillus fumigatus is the major causative agent of aspergillosis in immunosuppressed hosts and patients with chronic pulmonary diseases. Recently, azole resistance of this fungus has become a problem worldwide; thus, rapid detection of resistant strains is desirable in clinical practice. In this study, we established a matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) combined with multivariate and discriminant analysis to detect azole-resistant A. fumigatus strains. The score plot from a partial least squares discriminant analysis clearly separated resistant and susceptible strains, regardless of the culture period. The discriminant analysis using the support-vector machine algorithm based on a dataset for strains cultured on potato dextrose agar for 3 days showed the best performance, with a correct answer rate of 84.75–99.85%. We found a MS peak (4359.5 m/z ) specific to some azole-resistant strains with a 34-bp tandem repeat in the promoter region of cyp51A . These tandem repeat strains are extremely rare in Japan. Instead, most resistant strains in Japan have point mutations in cyp51A . No specific biomarker for strains with point mutations was found, but it was possible to detect these resistant strains using a model for point-mutation strains.
Designing the Product Development Process (2007)

Even though the literature on product and process development is extensive, not much attention has been devoted to categorizing the product development process itself. Existing work on product development processes such as Total Design, Integrated Product and Process Design among others advocate common approaches that should be followed throughout the organization, without any consideration of product characteristics. In this paper we review several existing development methodologies. Extensions of these are categorized by their applicability to different classes of products. We propose that development processes should be matched to product attributes and organization goals. Towards this end, we associate development processes along with their components such as House of Quality, Robust Design, TRIZ etc. with goals such as time to market, customer needs satisfaction, intellectual property generation, protection and exploitation, quality, product cost and others. We examine the impact of this association on the development process itself and propose guidelines for constructing specific processes associated with one or more goals. Tools and benchmarks for various applications are discussed, along with some case studies on the design of different development processes.
Streamlining SAE Reporting for CTN Trials Results In Significant Time Savings (2009)

Reporting serious adverse events (SAEs) for Blood and Marrow Transplant Clinical Trials Network (CTN) studies generally requires detailed information to be entered into the EMMES database so that a medical director can review it and determine whether the event is expected or unexpected. When SAE reporting requires reporting concomitant medications, lengthy amounts of time are spent identifying and recording these medications. If the event is determined to be expected, a report is not required and the data manager is requested to delete the information that was entered. The University of Michigan (U of M) set out to find an alternative that would save the time required to enter information that may ultimately be deleted. During a routine CTN audit in January 2008, U of M data managers worked with auditors to develop a solution centered around who determines that an event is expected. For all SAEs requiring an initial report to CTN, a report must also be filed with the U of M Institutional Review Board (IRB). Because reports submitted to the IRB require the local principal investigator to make a determination whether an event is expected or unexpected, it seemed redundant to have CTN also perform the same evaluation. With a new function in the EMMES database that allows sites to upload supporting documents for SAE reporting, a solution was reached whereby the SAE reports submitted to the U of M IRB could also be uploaded into the EMMES system for the medical director's review. Thus the requirement to enter detailed information that might ultimately have to be deleted was eliminated. The University of Michigan Clinical Trials Office utilizes a time and effort tracker tool that records and categorizes data management time spent on study related tasks. This tool was used to evaluate the amount of time spent reporting SAEs during 2007 (prior to the CTN audit) and for the 7 months in 2008 after implementing the new reporting process for 5 CTN trials open during the two time periods. In order to compare across time periods of different length, average SAE reporting time per event was compared. We found time savings for each study, ranging from 0.22 to 1.89 hours per SAE, with an average savings of approximately one hour per SAE. When multiplied by the 114 SAEs reported on these studies alone, time savings approach 3 weeks of data management time. If this system was extended across the entire network the time and money savings could be substantial.Tabled 1Time Requirements for SAE ReportingStudy# SAE reports Jan-Dec 2007Total reporting hoursHours per SAE# SAE reports Feb-Aug 2008Total reporting hoursHours per SAESavings in HoursCTN 020110212.11619.31.210.89CTN 05011135.53.21013.41.341.89CTN 030220311.5511131.180.37CTN 0401824.33.0433.51.171.87CTN 04021129.52.681434.52.460.22Total60144.65483.72Average2.511.471.04 Open table in a new tab
Behavior of almond oil bodies during in vitro gastric and intestinal digestion (2012)

An aqueous suspension of almond oil bodies (about 10% lipids) was prepared and subjected to in vitro gastric (with pepsin) and intestinal (with bile salts and pancreatin) digestion, simulating fasting conditions. The physicochemical and structural changes of the almond oil body emulsion were examined. The almond oil body emulsion behaved similarly to a protein-stabilized emulsion, with flocculation of the oil bodies occurring under gastric conditions. Proteins, peptides, and phospholipids covered the surface of the oil bodies throughout gastric digestion. Under intestinal conditions, bile salts displaced the interfacial peptides and phospholipids, and disrupted the flocs. Gastric pepsinolysis of almond proteins was a prerequisite for their digestion in the duodenum. The oil body membrane had a negative impact on the efficiency of gastric digestion, and long chain fatty acids, the main lipolytic products, accumulated at the surface of the oil bodies and therefore limited the activity of pancreatic lipase.
Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens (2015)

Invasive pulmonary aspergillosis (IPA) is an opportunistic fungal infection in patients undergoing chemotherapy for hematological malignancy, hematopoietic stem cell transplant, or other forms of immunosuppression. In this group, Aspergillus infections account for the majority of deaths due to mold pathogens. Although early detection is associated with improved outcomes, current diagnostic regimens lack sensitivity and specificity. Patients undergoing chemotherapy, stem cell transplantation and lung transplantation were enrolled in a multi-site prospective observational trial. Proven and probable IPA cases and matched controls were subjected to discovery proteomics analyses using a biofluid analysis platform, fractionating plasma into reproducible protein and peptide pools. From 556 spots identified by 2D gel electrophoresis, 66 differentially expressed post-translationally modified plasma proteins were identified in the leukemic subgroup only. This protein group was rich in complement components, acute-phase reactants and coagulation factors. Low molecular weight peptides corresponding to abundant plasma proteins were identified. A candidate marker panel of host response (9 plasma proteins, 4 peptides), fungal polysaccharides (galactomannan), and cell wall components (β-D glucan) were selected by statistical filtering for patients with leukemia as a primary underlying diagnosis. Quantitative measurements were developed to qualify the differential expression of the candidate host response proteins using selective reaction monitoring mass spectrometry assays, and then applied to a separate cohort of 57 patients with leukemia. In this verification cohort, a machine learning ensemble-based algorithm, generalized pathseeker (GPS) produced a greater case classification accuracy than galactomannan (GM) or host proteins alone. In conclusion, Integration of host response proteins with GM improves the diagnostic detection of probable IPA in patients undergoing treatment for hematologic malignancy. Upon further validation, early detection of probable IPA in leukemia treatment will provide opportunities for earlier interventions and interventional clinical trials.