gebhart/patrepeval huggingface dataset:
A tiling of phase-space through self-convolution (2000)

A novel tiling for Fourier half space is constructed using Erlang functions. This tiling is constructed by shifts in discrete-time and self-convolutions in the Fourier domain. We show that a subframe of this complex wavelet family can be used for the detection and characterization of events (step and peaks) in one-dimensional (1-D) discrete-time signals.
Influence of Moisture Conditioning on Linear Viscoelastic Behaviour of Bituminous Mixtures Used For Railway Trackbeds (2016)

Abstract The influence of moisture on the linear-viscoelastic properties of bituminous mixtures with and without polymer modified bitumen (PMB) to be used for railway trackbeds was addressed in this paper. Nowadays, the use of bituminous mixtures in railway trackbeds, particularly for new high-speed lines, is a common practice. The variation of the thermomechanical properties of bituminous mixtures needs to be characterized considering railway loading, circulation speed, and environmental exposure conditions. For this purpose, improved 3D complex modulus tests were performed on base-course type mixtures. A tri-dimensional constitutive model, called 2S2P1D (2 Springs, 2 Parabolic creep elements and 1 Dashpot), was used to model the viscoelastic behavior of the materials. A moisture conditioning procedure was used to induce moisture damage to the mixtures. The thermomechanical properties of the materials are compared for the conditioned and non-conditioned states. Low variation of the linear viscoelastic behavior of the studied materials after moisture conditioning was observed. The results allowed assessing the interest of using polymer modified bitumen for bituminous mixtures to be used in railway trackbeds.
Oligosaccharide Sensing Using Fluorophore-Probed Curdlans in Aqueous Media (2023)

Saccharide sensing in aqueous media has recently garnered considerable attention in supramolecular and analytical chemistry; however, it still faces significant challenges. Herein, we report oligosaccharide sensing using the designed and synthesized fluorophore-probed curdlans. Aggregation-induced emission of the tetraphenylethylene (TPE) chromophore is a powerful candidate for outputting fluorescence signals upon the addition of the target oligosaccharide acarbose. Among the saccharides tested, the TPE-Cur chemosensors simultaneously exhibited high sensitivity and excellent selectivity toward acarbose. Morphological studies using atomic force microscopy, dynamic light scattering, fluorescence spectroscopy, and lifetime measurements revealed the importance of globule-to-coaggregation conversion upon oligosaccharide incorporation into the dynamic hydrogen-bonding networks of the curdlan string. This study provides perspectives for saccharide-responsive materials that are an attractive alternative to conventional chemosensors, which are difficult to sense in aqueous media.
Antibody restores human alternative complement pathway activation by mouse erythrocytes rendered functionally deficient by pretreatment with pronase. (1982)

Activation of the human alternative pathway of complement (C) by surfaces requires the initial deposition of C3b by fluid-phase C3 convertase and sustained C3 cleavage by C3 convertases fixed to the surface. Nonactivating particles have previously been characterized by an inability to sustain the function of C3 convertases on their surfaces because these sites were susceptible to the regulatory action of the control proteins. Pronase converts the mouse erythrocyte (E) from an activator to a nonactivator by markedly decreasing the ability of the cell to affix C3b generated by a fluid-phase C3 convertase; this conversion is unrelated to the action of the control proteins on bound C3b. The capacity of antibody and its F(ab')2 or Fab' fragments to restore the alternative pathway-activating function of pronase-treated mouse E indicates that the contribution of antibody is mediated by its combining site without a requirement for bridging or for the Fc portion. The fab'-dependent activation of the alternative pathway of C relates to the deposition of C3b on the particle surface, which is a first and continuing step in alternative pathway activation. The antibody effect is not directed to the action of the regulatory proteins. Thus, particle-dependent activation of the alternative C pathway has been shown for the first time to be abolished and restored by cell surface-directed mechanisms that function independently of the regulatory proteins.
Athermal all-polymer arrayed-waveguide gratingmultiplexer (2001)

An athermal arrayed-waveguide grating (AWG) multiplexer relying on an all-polymer approach is reported. The all-polymer AWG consisting of polymer waveguides fabricated on a polymer substrate exhibits excellent performance. By properly adjusting the coefficient of thermal expansion of the polymer substrate, athermal and polarisation-independent AWG devices featuring a wavelength shift of less than ±0.05 nm in the 25-65°C temperature range could be demonstrated.
Nature of reissert analogs derived from N,N‐dialkyl and N,N‐diaryl carbamoyl chlorides (1985)

Abstract Reissert analogs were prepared from the reaction of isoquinoline and phthalazine with carbamoyl chlorides and cyanide using the methylene chloride‐water method. Alkylation, condensation, Michael addition, and hydrolysis reactions of these Reissert analogs have been studied and found in many cases, to be similar to those of the isoquinoline Reissert compound.
Privacy (2015)

“Privacy” is widely recognized as a legal right, but with a range of different meanings: restraints on intrusion into the home, confidentiality of correspondence, freedom to make certain fundamental decisions, control of personal data, anonymity, among many others. Countries differ as to the specific understandings of privacy their laws protect and whether those understandings apply equally against the government and private sector entities.
Results of early aneurysm surgery in poor-grade patients (1994)

A series of 76 poor-grade (Hunt and Hess IV and V) patients after aneurysmal subarachnoid haemorrhage and early operation, was investigated in terms of post-operative outcome. The overall outcome was favourable in 41 (54%) patients and unfavourable in 35 (46%) patients. The mortality rate of 28% in all poor-grade patients after early surgery was acceptable, compared to mortality rates ranging from approximately 95% to 100% in regimes with nonsurgical treatment.
Rule-based video classification system for basketball video indexing (2000)

Current information and communication technologies provide the infrastructure to send bits anywhere, but do not presume to handle information at the semantic level. This paper investigates the use of video content analysis and feature extraction and clustering techniques for further video semantic classifications and a supervised rule based video classification system is proposed. This system can be applied to the applications such as on-line video indexing, filtering and video summaries, etc. As an experiment, basketball video structure will be examined and categorized into different classes according to distinct visual and motional characteristics features by rule-based classifier. The semantics classes, the visual/motional feature descriptors and their statistical relationship are then studied in detail and experiment results based on basketball video will be provided and analyzed.
Design of DCS duplexer using SAW ladder filter (2005)

The frequency responses of SAW ladder filters, which consist of a one-port resonator in a parallel arm and one in a series arm, are investigated and their applications in designing a duplexer are also illustrated. The one-port resonators with apodized interdigital transducers and width-controlled reflection gratings are employed to increase the operating bandwidth as well as to suppress the effects of spurious modes. The transmission matrix method along with the image parameter method is applied to design the duplexer, which consists of two SAW ladder filters connected in parallel. Simulation results indicate that with a proper design of transmission line for impedance matching, a switchless duplexer with very low loss can be tailored using SAW devices.
Ultrafast detection of charged photocarriers in conjugated polymers (2000)

Ultrafast measurements of transient excited-state absorption in the spectral region spanning the infrared-active vibrational active (IRAV) modes in the prototypical luminescent polymers, poly(phenylene vinylene) (PPV) and poly[2-methoxy-5-(2-ethyl-hexyloxy)-(phenylene vinylene)] (MEH-PPV), reveal charge carrier generation within 100 fs after photoexcitation. The photocarrier quantum efficiency in MEH-PPV is ${\ensuremath{\varphi}}_{0}\ensuremath{\approx}0.1$ in zero applied electric field. There is no correlation between the temporal behavior of the photoinduced IRAV signals and the exciton lifetime. Thus, carriers are photoexcited directly and not generated via a secondary process from exciton annihilation. Comparison of the recombination dynamics in MEH-PPV and PPV demonstrates the importance of the strength of interchain interaction on the carrier recombination dynamics. The quantum efficiency is the same $({\ensuremath{\varphi}}_{0}\ensuremath{\approx}0.1)$ when the system is pumped either at photon energies well above the first $\ensuremath{\pi}\ensuremath{-}{\ensuremath{\pi}}^{*}$ transition (at 267 nm, 4.7 eV) or when pumped into the first $\ensuremath{\pi}\ensuremath{-}{\ensuremath{\pi}}^{*}$ transition (at 400 nm, 3.1 eV). The carrier lifetime, however, increases at the higher photon energy, providing a natural explanation for the increase in the photoconductivity at photon pump energies above 3 eV.
ChemInform Abstract: NOVEL SYNTHESIS OF THIOPHENE‐3‐MALONIC ESTERS AND THEIR SELENOPHENE ANALOGS (1979)

Abstract Die Knoevenagelkondensate (I) werden durch Behandlung mit Schwefelwasserstoff / Kaliumhydroxid/Ethanol, Natriumhydrogensulfid/wäßr. Methanol oder mit Natriumsulfid in Tetrahydrofuran zu den Thiophenen (II) cyclisiert.
ChemInform Abstract: THE LUMINESCENCE OF TETRAVALENT MANGANESE IN MANGANESE‐DOPED CALCIUM ZIRCONATE (1981)

Abstract Die Emissions‐ und Anregungsspektren einer unterhalb 20°C in CaZrO3:Mn‐Kristallen auftretenden effizienten roten Lumineszenz des Mn4 ‐Ions werden diskutiert und zugeordnet.
Both the Establishment and Maintenance of Neuronal Polarity Require the Activity of Protein Kinase D in the Golgi Apparatus (2008)

Neuronal polarization requires coordinated regulation of membrane trafficking and cytoskeletal dynamics. Several signaling proteins are involved in neuronal polarization via modulation of cytoskeletal dynamics in neurites. However, very little is known about signaling proteins in the neuronal soma, which regulate polarized membrane trafficking and neuronal polarization. Protein kinase D (PKD) constitutes a family of serine/threonine-specific protein kinases and is important in regulating Golgi dynamics and membrane trafficking. Here, we show that two members of the PKD family, PKD1 and PKD2, are essential for the establishment and maintenance of neuronal polarity. Loss of function of PKD with inhibitor, dominant negative, and short interfering RNA disrupts polarized membrane trafficking and induces multiple axon formation. Gain of function of PKD can rescue the disruption of polarized membrane trafficking and neuronal polarity caused by cytochalasin D, which results in F-actin depolymerization. PKD1 and PKD2 are also found to be involved in the maintenance of neuronal polarity, as evidenced by the conversion of preexisting dendrites into axons on PKD inhibition. Unlike other polarity proteins, PKD does not interact with the cytoskeleton in neurites. Instead, PKD regulates neuronal polarity through its activity in the Golgi apparatus. These data reveal a novel mechanism regulating neuronal polarity in the Golgi apparatus.
Cover Image, Volume 29, Issue 11 (2019)

Cover legend: This cover image is based on the Research Article Postnatal Nectin-3 Knockdown Induces Structural Abnormalities of Hippocampal Principal Neurons and Memory Deficits in Adult Mice by Rui Liu et al, DOI: 10.1002/hipo.23098.
Postoperative complications predict poor outcomes only in patients with a low modified clinical score after resection of colorectal liver metastases: a retrospective cohort study (2022)

The aim was to identify the optimal criteria of postoperative complications (POCs) for predicting oncological outcomes after hepatectomy for colorectal liver metastases (CRLMs) and to investigate the variable prognostic implications of POCs according to the modified clinical score (M-CS). We identified 751 patients who underwent curative hepatic resection for CRLM between 2007 and 2018. Patients were categorized based on the M-CS. The impact of the severity [≥ Clavien-Dindo grade (C-D) III or comprehensive complication index (CCI) ≥ 26.2] or type [any infectious complications of POC (Inf-poc)] of POC on overall survival (OS) and recurrence-free survival (RFS) was assessed by univariate and multivariable analyses in different groups. Patients with a major or infectious complication were not associated with either RFS or OS in multivariable analysis of the whole cohort. However, patients with a high CCI had a worse OS (HR 1.51, P = 0.004). Among patients with low M-CS, patients with high CCI had worse OS (HR 1.49, P = 0.035) and RFS (HR 1.32, P = 0.048) than those without high CCI. In contrast, the survival disadvantage of a high CCI was not present in patients with a high M-CS. Compared to Inf-poc or major complications, a high CCI decreased long-term OS in patients treated with hepatectomy for CRLM. High CCI has a variable prognostic impact after hepatic resection for CRLM depending on the M-CS. POC is not a decisive factor to justify the use of hepatectomy for CRLM in patients with high M-CS.
QUALITY CONTROL AND STEADY WIDE-AREA SUPPLY OF HIGH CONTENT OF RECYCLED ASPHALT MIXTURE (2017)

わが国の道路舗装は着々と整備され，現在では約100万kmにもおよぶ膨大な舗装ストックとなっている．一方，社会資本整備費は減少しており，この傾向は今後も続くものと予想される．したがって，今後は舗装ストックの効率的な維持管理と将来にわたり持続安定的なアスファルト混合物の供給が望まれる． また，近年のアスファルト舗装はリサイクルが進み，再生アスファルト混合物の使用割合が増加するとともに，再生率も高くなっている．こうした中，このようなリサイクルを品質低下させることなく，持続的に繰り返していく必要がある． 本研究では高再生率に対応した微細発泡技術および再生用添加剤の発泡技術により，上記の課題の品質確保および可使時間延長による供給エリアの拡大を図り，今後の方向性の一案を提言した．
Direct and indirect excitation of Er3+ ions in Er: AIN (1997)

Photoluminescence (PL) excitation and time-resolved PL measurements were conducted on erbium doped AlN. The Er:AlN film was grown by metal organic molecular beam epitaxy with a solid Er effusion source. The resulting Er concentration was 2–5×1019 Er/cm3. Photoluminescence excitation measurements revealed that Er3+ in Er:AlN can be excited either through direct optical pumping into Er3+ 4f levels or through an indirect carrier-mediated process. With respect to these two Er3+ excitation schemes, distinct Er3+ PL decay patterns were observed. The Er3+ PL excited by direct optical excitation was longer lived than that excited via a carrier-mediated process. Time-resolved PL measurements support that at least two classes of Er3+ PL centers exist in Er:AlN, and that direct optical excitation of Er3+ 4f levels primarily excites a set of longer-lived Er3+ sites which are not excited through carrier-mediated processes.
Abstract 4911: HPV-independent methylation of specific TGF-B pathway-relevant genes in head and neck squamous cell carcinomas associated with prior radiation therapy and exposure to alcohol and tobacco (2010)

Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with more than half a million people being diagnosed with the disease annually. Therefore, it is critical to identify early detection markers, such as DNA methylation, for more timely diagnosis. In a recent study, we identified five tumor suppressive genes (IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18) as frequently methylated in HNSCC biopsies using a global methylation analysis via restriction landmark genomic scanning (RLGS). Interestingly, we found these candidates are all potentially involved in the TGF-B signaling pathway, which is often disrupted in HNSCC. Therefore, we sought to determine coordinated epigenetic silencing of these candidate genes in HNSCC as potential key disruptors of TGF-B signaling, which could ultimately result in HNSCC progression. Through immunoprecipitation studies, all five of the investigated candidate genes were found to interact with components of the TGF-B pathway. Also, overexpression of SLC5A8, EBF3, and IRX1 resulted in decreased mitotic activity and increased apoptosis. These findings are significant because they reveal a set of genes that interact with components of the TGF-B pathway, and their silencing via methylation in HNSCC results in coordinated decrease in apoptosis, increased proliferation, and decreased differentiation. We went on to define the methylation of these genes in relationship to HPV16-positivity, radiation therapy, and alcohol and tobacco exposure. By utilizing the available clinical information linked to the patient specimens, we found a strong association between promoter methylation of FUSSEL18, IRX1, and EBF3 and prior radiation therapy (P &amp;lt; 0.0001) irrespective of HPV status. Also, promoter methylation of FUSSEL18 and SEPTIN9 were found to correlate significantly with exposure to alcohol and tobacco (P = 0.021). Importantly, in this study we preliminarily show a trend between HPV16 positivity and specific target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. Equally notable and independent of HPV status, hypermethylation of the promoters of a subset of these genes in recurrences especially in the setting of prior radiation or in the setting of alcohol and tobacco use might help guide adjunctive inclusion or exclusion or epigenetic therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4911.
Abstract IA005: Discovery and development of LFA-9 for CRC prevention (2022)

Abstract Colorectal Cancer (CRC) is a major public health issue with an estimated 980,000 deaths annually, worldwide. Current trends show an increase of CRC incidence and mortality worldwide. Colonic adenomas are very common in ages 50 and over. Though, nonsteroidal antiinflammatory agents like Aspirin, Naproxen and COX-2 inhibitor and Celecoxib are useful to prevent the polyp progression and reducing CRC burden, continuous/chronic usage of these drugs are limited by GI toxicity and unwanted side effects. Thus, the rationale to establish safer anti-inflammatory agents for CRC prevention is important. Mechanistic studies suggest that up-regulation of 15-PGDH, sparing COX-1/2 and prostaglandin (PG)I2 synthase and/or selectively targeting mPGES-1 and 5-LOX would reduce the cardiovascular side effects and may improve the chemopreventive efficacy. There are limited to no studies on targeting mPGES-1/5LOX and it is one of the unexplored areas in colorectal cancer chemoprevention towards safer drug development. To design and develop selective inhibitors of dual mPGES-1/5-LOX, we used in-silico small molecular docking simulation approaches, and identified LFA-9 as a novel duel mPGES-1/5-LOX inhibitor among &amp;gt;35 analogs. Azoxymethane (AOM)-induced rat colonic tumors were utilized as ex-vivo to assess pharmacodynamic inhibitory effects of LFA-9 on mPGES-1 and 5-LOX by Radio-HPLC. In a series of animal experiments, we established the dose-range of toxicity and optimal doses of LFA-9. Potential preventive efficacy of LFA-9 was assessed AOM-rat colon carcinogenesis (Aberrant Crypt Foci, (ACF) as surrogate marker in male F344 rats and intestinal tumor inhibition in APCMin/+ mice. Furthermore, we have shown the efficacy of LFA-9 administered in the diet at the adenoma stage significantly suppressed colonic adenocarcinoma formation in AOM-induced colon cancer (sporadic CRC model) and PIRC rat model (FAP model). Overall, the above results show that LFA-9, a novel dual mPGES-1/5-LOX inhibitor, is a safer agent and has potential for prevention of CRC in high-risk patients. {This work was supported by NCI-PREVENT Cancer Program, R01 CA213987 and VA Merit Awards} Citation Format: Chinthalapally V. Rao. Discovery and development of LFA-9 for CRC prevention [abstract]. In: Proceedings of the Second Biennial NCI Meeting: Translational Advances in Cancer Prevention Agent Development (TACPAD); 2022 Sep 7-9. Philadelphia (PA): AACR; Can Prev Res 2022;15(12 Suppl_2): Abstract nr IA005.
Darstellung und Spaltung von α‐Benzolazo‐alkoholen (1968)

Abstract Die Darstellung einer neuen Verbindungsklasse, der α‐Benzolazo‐alkohole, wird beschrieben. Die Spaltung dieser Substanzen in saurer Lösung liefert entweder das Phenylhydrazon eines Aldehyds und einen Aldehyd bzw. ein Keton (offenkettiger Benzolazo‐alkohol) oder das Monophenylhydrazon eines Dialdehyds (cyclischer Benzolazo‐alkohol).
Reduction of X-Ray Lethality in Mice by Agents Affecting the Reticuloendothelial System (1961)

Mortality of mice irradiated several weeks after administration of mycobacterium tuberculosis and zymosan was significantly reduced. There was no accelerated recovery of hemopoietic and lymphatic tissue in the protected animals. Certain enhanced activities of the reticuloendothelial system related to increased nonspeciflc resistance were still evident after lethal irradiation. A correlation between resistance to near-lethal irradiation and certain parameters reflecting the functional state of phagocytic elements of the reticuloendothelia1 system is postulated.
Highly X-Tolerant Selective Compaction of Test Responses (2009)

The paper presents a new scan chain selection scheme for response compaction. The proposed solution performs selective masking of scan chains and handles a wide range of unknown state profiles, such that all X states can be eliminated in a per-cycle mode while preserving high observability of scan cells that capture errors.