gebhart/patrepeval huggingface dataset:
Outcome of elderly patients with acute promyelocytic leukemia: results of the German Acute Myeloid Leukemia Cooperative Group (2012)

Despite improvement of prognosis, older age remains a negative prognostic factor in acute promyelocytic leukemia (APL). Reports on disease characteristics and outcome of older patients are conflicting. We therefore analyzed 91 newly diagnosed APL patients aged 60 years or older (30 % of 305 adults with APL) registered by the German AML Cooperative Group (AMLCG) since 1994; 68 patients (75 %) were treated in studies, 23 (25 %) were non-eligible, and 31 % had high-risk APL. Fifty-six patients received induction therapy with all-trans retinoic acid and TAD (6-thioguanine, cytarabine, daunorubicin), and consolidation and maintenance therapy. Treatment intensification with a second induction cycle (high dose cytarabine, mitoxantrone; HAM) was optional (n = 14). Twelve patients were randomized to another therapy not considered in this report. The early death rate was 48 % in non-eligible and 19 % in study patients. With the AMLCG regimen, 7-year overall, event-free and relapse-free survival (RFS) and cumulative incidence of relapse were 45 %, 40 %, 48 %, and 24 %, respectively. In patients treated with TAD-HAM induction, 7-year RFS was superior (83 %; p = 0.006) compared to TAD only, and no relapse was observed. In our registered elderly patients, we see a high rate of non-eligibility for treatment in studies and of high-risk APL. In patients who can undergo a curative approach, intensified chemotherapy is highly effective, but is restricted to a selection of patients. Therefore, new less toxic treatment approaches with broader applicability are needed. Elderly patients might be a particular target group for concepts with arsenic trioxide.
Synthesis of Nanocrystal Titania Sol with Different Ratio of Rutile and Anatase at Low Temperature (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Interactions between Automotive Shredder Residue and Olivine Bed Material during Indirect Fluidized Bed Gasification (2021)

Thermal conversion of automotive shredder residue (ASR) using indirect fluidized bed gasification was conducted in the Chalmers semi-industrial 2-4-MWth gasifier. The bed material consisted of olivine that was activated through the deposition of biomass ash prior to a 13-day exposure to ASR. The interactions between the bed material and the ASR ash were investigated using XRD, SEM-EDS, and thermodynamic modeling. The deposition of iron (Fe) onto the olivine particles was noted, and this is likely to increase the oxygen-carrying ability of the particles. Furthermore, at the end of the campaign, about one-third of the particles in the bed were found to originate from the ASR ash. These particles were rich in Fe and Si, as well as elements found exclusively in the ASR ash, such as Zn, Ti, and Cu. Some of these particles exhibited a hollow morphology, suggesting a melt state during their formation in the gasifier. In addition, a low level of agglomeration of the ash and olivine particles was detected. Thermodynamic modeling with the FactSage software indicated the formation of slag. This study presents a detailed investigation of the interactions that occur between the bed material and an ash-rich fuel such as ASR. The findings may have applications in demonstrating the induction of oxygen-carrying ability in bed materials or for metal recycling through the separation of ash particles from the bed material.
Model-based vision for automatic alarm interpretation (2002)

In a previous paper T.J. Ellis et al. (1989) described the development of a knowledge-based vision recognition system for automating the interpretation of alarm events resulting from a perimeter intrusion detection system (PIDS). Measurements extracted over a sequence of digitized images are analyzed to identify the cause of alarm. Models are maintained for both alarm causes and the scene and the measurements are matched with the models to derive an appropriate classification of the event. The authors record progress on the further development of the system and present the results of applying it to a number of real alarms. The system is shown to behave robustly, correctly classifying genuine alarm events (i.e., human intruders) and providing statistics of false alarm events.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
[Control of implantation in rats and sows by peroral administration of prostaglandin synthetase inhibitors. 2. Effects of prostaglandin F2 alpha, progesterone/estrone, and acetylsalicylic acid on implantation and various biochemical parameters of amniotic fluid in the rat]. (1981)

The highest pregnancy rate as well as most of all implantates and lowest foetal loss were recorded from the prostaglandin F2 alpha-(PGF2 alpha)-group (84, 84, and 16 per cent), while values following progesterone/oestrone and acetylsalicylic acid treatment were below those obtained from the controls. The highest number of normally developed (97 per cent) and the lowest number of degenerated foetuses (three per cent) were recorded following acetylsalicylic acid treatment, as compared to the control group (91 and nine per cent). Application of prostaglandin had no adverse effect on foetal development. The overall protein concentration in the amniotic fluid, following injection of progesterone/oestrone and PGF2 alpha, was lower with significance than the control value. Acetylsalicylic acid caused slight but insignificant rise in protein concentrations. The behavior of glucose concentrations in the amniotic fluid seemed to be diametrically opposed to that of protein. The activity of acid phosphatase was low and highly variable in all four experimental groups. Values moderately increased over the controls were recorded from the acetylsalicylic acid group.
Harmonizing Outcomes for Genomic Medicine: Comparison of eMERGE Outcomes to ClinGen Outcome/Intervention Pairs (2018)

Genomic medicine is moving from research to the clinic. There is a lack of evidence about the impact of genomic medicine interventions on health outcomes. This is due in part to a lack of standardized outcome measures that can be used across different programs to evaluate the impact of interventions targeted to specific genetic conditions. The eMERGE Outcomes working group (OWG) developed measures to collect information on outcomes following the return of genomic results to participants for several genetic disorders. These outcomes were compared to outcome intervention pairs for genetic disorders developed independently by the ClinGen Actionability working group (AWG). In general, there was concordance between the defined outcomes between the two groups. The ClinGen outcomes tended to be higher level and the AWG scored outcomes represented a subset of outcomes referenced in the accompanying AWG evidence review. eMERGE OWG outcomes were more detailed and discrete, facilitating collection of relevant information from health records. This paper demonstrates that common outcomes for genomic medicine interventions can be identified. Further work is needed to standardize outcomes across genomic medicine implementation projects and make these publicly available to enhance dissemination and assist in making precision public health a reality.
Universal Intramedullary Instrumentation for Unicompartmental Total Knee Arthroplasty (1991)

Certainly the advantages of unicompartmental total knee arthroplasty (TKA) are appealing as opposed to tricompartmental arthroplasty. Patients who have had unicompartmental arthroplasty have significant preservation of existing bone stock. They have an improved range of motion and they are definitely easier to revise. This reduces hospitalization time as well as costs with retention of more normal anatomy. In patients with unicompartmental disease with minimal patellofemoral changes, clinical results are certainly encouraging in terms of patient satisfaction with unicompartmental arthroplasty as opposed to tricompartmental arthroplasty. Restoration of function is unquestionably closer to normal than with tricompartmental arthroplasty. The advantages of an intramedullary instrumentation system for unicompartmental disease allows for a more standard method of placing unicompartmental prosthetic components so that less "eyeballing" occurs. Furthermore, utilization of a system that allows for more precise anatomical cuts should allow for better component fit as well as a return to a more normal femoral-tibial angle.
A 98.55% Efficiency Switched-Tank Converter for Data Center Application (2018)

Achieving high efficiency and high power density features of intermediate bus converter (IBC) in data center application is very critical. This paper proposes a nonisolated switched-tank dc-dc converter (STC) to meet the high requirement of IBC. The proposed STC has fixed voltage conversion ratio. Theoretical analysis provides the guideline for designing resonant tank and nonresonant tank as well as selecting proper deadtime for the proposed circuit. With resonant operation feature of the proposed circuit, zero current switching is realized on all switching devices to help the high-efficiency operation of the proposed converter. Through the proposed design methodology in this paper, power loss on switching devices and planar inductors can be minimized. In addition, detailed power loss analysis and breakdown provide hints for further efficiency improvement. Simulation has been performed to validate the operating principle of the proposed STC. A designed 6x STC (450 W nominal/600 W maximum) based on eGaNFETs is demonstrated. With 54 V typical input voltage, the output of the 6x STC is 9 V. The GaN-based prototype achieves a peak efficiency of 98.55%. Also, it achieves 97.18% efficiency and 750 W/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> power density at 450 W.
Power Loss Minimization in Distribution System Using Network Reconfiguration in the Presence of Distributed Generation (2012)

This paper presents a new method to solve the network reconfiguration problem in the presence of distributed generation (DG) with an objective of minimizing real power loss and improving voltage profile in distribution system. A meta heuristic Harmony Search Algorithm (HSA) is used to simultaneously reconfigure and identify the optimal locations for installation of DG units in a distribution network. Sensitivity analysis is used to identify optimal location s for installation of DG units. Different scenarios of DG placement and reconfiguration of network are considered to study the performance of the proposed method. The constraints of voltage and branch current carrying capacity are included in the evaluation of the objective function. The method has been tested on 33-bus and 69-bus radial distribution systems at three different load levels to demonstrate the performance and effectiveness of the proposed method. The results obtained are encouraging.
High-Dose Corticosteroids in Patients with the Adult Respiratory Distress Syndrome (1988)

BERNARD, G. R.; LUCE, J. M.; SPRUNG, C. L.; RINALDO, J. E.; TATE, R. M.; SIBBALD, W. J.; KARIMAN, K.; HIGGINS, S.; BRADLEY, R.; METZ, C. A.; HARRIS, T. R.; BRIGHAM, K. L. Author Information
The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program (2017)

The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and provides estimates using the SLICC criteria.
A Parallel Algorithm for the Reduction to Tridiagonal Form for Eigendecomposition (1999)

One-sided orthogonal transformations which orthogonalize columns of a matrix are related to methods for finding singular values. They have the advantages of lending themselves to parallel and vector implementations and simplifying access to the data by not requiring access to both rows and columns. They can be used to find eigenvalues when the matrix is given in factored form. Here, a finite sequence of transformations leading to a partial orthogonalization of the columns is described. This permits a tridiagonal matrix whose eigenvalues are the squared singular values to be derived. The implementation on the Fujitsu VPP series is discussed and some timing results are presented.
Expression of VEGFR and PDGFR‐α/‐βin 187 canine nasal carcinomas (2016)

Radiotherapy represents the standard of care for intranasal carcinomas. Responses to tyrosine kinase inhibitors (TKIs) have been reported but data on expression of target receptor tyrosine kinases (rTKs) is limited. This study characterizes the expression of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR)-α and PDGFR-β in canine intranasal carcinomas. Histological samples from 187 dogs were retrieved. Immunohistochemistry was performed using commercially available antibodies. Expression of rTKs was classified into weak, moderate or intense and additionally recorded as cytoplasmic, membranous, cytoplasmic-membranous, nuclear or stromal. VEGFR was expressed in 158 dogs with predominantly moderate expression (36.9%) and a cytoplasmic-membranous expression pattern (70.9%). PDGFR-α was detected in 133 with predominantly weak expression (57.9%) and cytoplasmic pattern (87.9%). PDGFR-β was identified in 74 patients with a predominantly moderate expression (17.6%) and cytoplasmic expression pattern (63.5%). Co-expression of rTKs was common. These results confirm expression of VEGFR, PDGFR-α and PDGFR-β in canine intranasal carcinomas and support the utility of TKIs.
Stability Analysis of a Hierarchical Architecture for Discrete-Time Sensor-Based Control of Robotic Systems (2014)

The stability of discrete time kinematic sensor-based control of robots is investigated in this paper. A hierarchical inner-loop/outer-loop control architecture common for a generic robotic system is considered. The inner loop is composed of a servo-level joint controller and higher level kinematic feedback is performed in the outer loop. Stability results derived in this paper are of interest in several applications including visual servoing problems, redundancy control, and coordination/synchronization problems. The stability of the overall system is investigated taking into account input/output delays and the inner loop dynamics. A necessary and sufficient condition that the gain of the outer feedback loop has to satisfy to ensure local stability is derived. Experiments on a Kuka K-R16 manipulator have been performed in order to validate the theoretical findings on a real robotic system and show their practical relevance.
Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins. (1994)

Proteins secreted by the yeast Saccharomyces cerevisiae are usually modified by the addition at asparagine-linked glycosylation sites of large heterogeneous mannan units that are highly immunogenic. Secreted proteins from mnn1 mnn9 mutant strains, in contrast, have homogeneous Man10GlcNAc2 oligosaccharides that lack the immunogenic alpha 1,3-mannose linkages. We have cloned and sequenced the MNN9 and MNN1 genes, both of which encode proteins with the characteristics of type II membrane proteins. Mnn9p is a membrane-associated protein with unknown function that is required for the addition of the long alpha 1,6-mannose backbone of the complex mannan, whereas Mnn1p is most likely the alpha 1,3-mannosyltransferase located in the Golgi apparatus.
Effects of Eccentricity on Glass Temperatures in the Neck-Down Stage of the Optical Fiber Drawing Process (1997)

Abstract A three-dimensional model of the neck-down stage of an optical fiber draw furnace was formulated to examine the effects of eccentricity on preform temperature and flow in the furnace. Eccentricity is an unavoidable off-manufacturing condition, which is the deviation between the centers of the cylindrical furnace and the glass preform rod. The Navier-Stokes and energy equations describing the momentum and thermal transfers in the draw furnace were solved simultaneously both in the glass and gas domains using the finite element method. Temperature dependent physical properties were considered. Radiation heat transfer was added into the model as surface-to-surface radiation between the glass surface and furnace wall, using a full enclosure analysis. Radiation inside the glass was approximated by using the Rosseland diffusion approximation. The circumferential temperature distribution and viscosity change on the preform surface were determined. They increase with the eccentricity ratio. The eccentricity is the distance between the furnace axis and the preform axis. The gas flow is unsymmetrical due to eccentricity. Most of the temperature gradients and viscosity changes were not large within the furnace due to eccentricity. A balanced temperature field in the furnace is due to the high radiation heat transfer. Since the preform necks down within the furnace and becomes thinner in the lower half, the glass becomes more isothermal due to its high radiation coupled glass conductivity. However, although the resulting temperature difference on the glass preform is small, the gradient is high. This temperature gradient becomes important when the exponential temperature dependence of the glass viscosity is considered. The resulting viscosity difference in the neck-down region will cause the glass to flow faster on one side than on the other side resulting in nonuniform consumption of the glass preform. Thus, the desired symmetric root shape of the glass preform may change.
Investigation of unique metal complexes produced with polystyrene-2,2'-bipyridine and several hydrogenation catalysts derived from this copolymer (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of unique metal complexes produced with polystyrene-2,2'-bipyridine and several hydrogenation catalysts derived from this copolymerRussell S. Drago, Eric D. Nyberg, and A. G. El A'mmaCite this: Inorg. Chem. 1981, 20, 8, 2461–2466Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/ic50222a019https://doi.org/10.1021/ic50222a019research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fully Photonic Integrated Wearable Optical Interrogator (2021)

Wearable technology constitutes a pioneering and leading innovation and a market development platform worldwide for technologies worn close to the body. Wearable optical fiber sensors have the most value for advanced multiparameter sensing in digital health monitoring systems. We demonstrated the first example of a fully integrated optical interrogator. By integrating all the optical components on a silicon photonic chip, we realized a stable, miniaturized and low-cost optical interrogator for the continuous, dynamic, and long-term acquisition of human physiological signals. The interrogator was integrated in a wristband, enabling the detection of body temperature and heart sounds. Our study paves the way for the development of watch-sized integrated wearable optical interrogators with potential applications in health monitoring and can be directly exploited for the customized design of ultraminiaturized optical interrogator systems.
A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5 (2008)

The yeast ABC transporter Pdr5 plays a major role in drug resistance against a large number of structurally unrelated compounds. Although Pdr5 has been extensively studied, many important aspects regarding its molecular mechanisms remain unresolved. For example, a striking degeneration of conserved amino acid residues exists in the nucleotide binding domains (NBDs), but their functional relevance is unknown. Here, we performed in vivo and in vitro experiments to address the functional asymmetry of NBDs. It became evident by ATPase activity and drug transport studies that catalysis at only one of the two NBD composite sites is crucial for protein function. Furthermore, mutations of the proposed "catalytic carboxylate" (E1036) and the "catalytic dyad histidine" (H1068) were characterized. Although a mutation of the glutamate abolished ATPase activity and substrate transport, mutation of H1068 had no influence on ATP consumption. However, the H1068A mutation abolished rhodamine transport in vivo and in vitro, while leaving the transport of other substrates unaffected. By contrast to mammalian P-glycoprotein (P-gp), the ATPase activity of yeast Pdr5 is not stimulated by the addition of substrates, indicating that Pdr5 is an uncoupled ABC transporter that constantly hydrolyses ATP to ensure active substrate transport. Taken together, our data provide important insights into the molecular mechanism of Pdr5 and suggest that not solely the transmembrane domains dictate substrate selection.
Electromagnetic techniques for mapping an underground coal gasification process. Final report, January 1, 1978-December 31, 1979 (1979)

An electromagnetic system, operating in reflection and transmission mode schemes, has been designed to monitor an underground coal seam gasification process. The overall dimensions of some system components have been restricted so that they may be placed inside a six-inch diameter borehole. Radiating elements have been designed, built, and tested to be used with the reflection and transmission mode schemes in the 174-216 MHz frequency range to monitor an underground coal gasification process within a thin (approx. = 6 feet height) coal seam. The system has been tested in a laboratory, with restricted physical dimensions, to validate some of its design concepts. In addition numerical algorithms and computer programs have been developed to map, from the transmission mode scheme measurements, the underground process and its surrounding environment. 20 references, 43 figures, 9 tables.