gebhart/patrepeval huggingface dataset:
OC06_06 Automatic Implementation of the Athlete’s Seattle Criteria Leads to Less than Ten Percent of Abnormal Electrocardiograms in General Young Population of Swiss Males (2016)

Electrocardiogram (ECG) biometrics is an advanced technology, not yet covered by guidelines on criteria, features and leads for maximal authentication accuracy.This study aims to define the minimal set of morphological metrics in 12-lead ECG by optimization towards high reliability and security, and validation in a person verification model across a large population.A standard 12-lead resting ECG database from 574 non-cardiac patients with two remote recordings (>1 year apart) was used. A commercial ECG analysis module (Schiller AG) measured 202 morphological features, including lead-specific amplitudes, durations, ST-metrics, and axes. Coefficient of variation (CV, intersubject variability) and percent-mean-absolute-difference (PMAD, intrasubject reproducibility) defined the optimization (PMAD/CV → min) and restriction (CV < 30%) criteria for selection of the most stable and distinctive features. Linear discriminant analysis (LDA) validated the non-redundant feature set for person verification.Maximal LDA verification sensitivity (85.3%) and specificity (86.4%) were validated for 11 optimal features: R-amplitude (I,II,V1,V2,V3,V5), S-amplitude (V1,V2), Tnegative-amplitude (aVR), and R-duration (aVF,V1).
Transition‐Metal Compounds Containing Alkynylsilyl Groups – Cyclopentadienyl Complexes (2012)

Abstract The synthesis of (alkynylsilyl)cyclopentadienyl complexes of titanium and manganese was studied. The titanium compounds PhC≡CMe 2 SiC 5 H 4 CpTiCl 2 ( 1 ) and (PhC≡CMe 2 SiC 5 H 4 ) 2 TiCl 2 ( 2 ) were prepared by treating LiC 5 H 4 SiMe 2 C≡CPh with suitable titanium(IV) halides. The manganese compound PhC≡CMe 2 SiC 5 H 4 Mn(CO) 3 ( 3 ) could be synthesized by treating Mn(CO) 5 Cl with TlC 5 H 4 SiMe 2 C≡CPh or LiC 5 H 4 SiMe 2 C≡CPh. Alternatively, the alkynylation of ClMe 2 SiC 5 H 4 Mn(CO) 3 ( 6 ) with PhC≡CMgBr was also successful. In contrast, the direct complexation of (alkynylsilyl)cyclopentadiene or the direct alkynylsilylation of cymantrene were not feasible. Redox reactions and the desilylation of the cyclopentadienyl ring were hampering side reactions in all routes but to varying extent. All three complexes were characterized by NMR spectroscopy. 1 and 3 were also studied by IR and UV/Vis spectroscopy. The molecular and crystal structure of compound 1 was determined by X‐ray diffraction analysis.
Dielectrophoretic sorting of lipid-containing microorganisms using high frequency electric fields produced by conducting post arrays (2015)

This paper describes a dielectrophoretic cell sorter containing arrays of conducting microposts. This sorter will be used to identify high-lipid-content organisms, which have commercial value for oil production and other applications. Cell sorting based on dielectrophoresis (DEP) typically utilizes planar electrodes, limiting throughput. Here, we present a rapid electroplating method that can produce an array of 15 μm tall posts in roughly ten minutes. Using this device, we were able to distinguish between two phenotypes of Yarrowia lipolytica, a lipid-containing yeast. In future work, we will use flow cytometry to confirm the lipid content of the sorted cell populations.
ChemInform Abstract: Rhodium‐Catalyzed Intermolecular [4 + 2] Cycloaddition of Unactivated Substrates. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Equity Flex Options : The Financial Engineer's Most Versatile Tool (1999)

1. Introduction. 2. The Institutional Options Revolution. 3. Applications of Equity FLEX Options. 4. Equity FLEX Options and Corporate Stock Repurchase Programs. 5. The Economics of Synthetic Stock Based on Equity FLEX Options. 6. Equity FLEX Procedures. Appendix A. Terms Used in Equity FLEX Transactions. Appendix B. When Will It Be Possible to Customize Call Strike Prices?. Index.
ChemInform Abstract: A New and Simple Synthesis of Cyclonon‐2‐ynone. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bacterial Survival in Snow Made from Wastewater (2000)

This study examined the effects of a patented wastewater treatment process that makes snow from secondary wastewater, and the subsequent freeze-thaw cycling processes that occur in a snow column, on bacterial survival. Coliform bacteria were observed to be the most adversely affected by snowmaking, with more than a 3-log reduction in the total coliform counts and more than a 2-log reduction in the fecal coliform counts. Other species of bacteria were less affected by snowmaking, especially the gram-positive, fecal streptococci. Many species of bacteria also survived the multiple freeze-thaw cycles in the snow column and replicated during melting.
Potassium Conductance Identity In Porcine Vas Deferens Epithelia (2006)

The ion transport mechanisms of the epithelia lining pig vas deferens play an important role in the modulation of luminal environment to which sperm are exposed. One or more basolateral K+ conductances are required to maintain membrane potential in presence of other ion transport mechanisms. We sought to determine the identity of such basolateral K+ conductance(s). The effects of various K+ channel inhibitors were tested on basolateral K+ conductance. Confluent primary cultures were used to measure short circuit current, Isc, an indicator of net ion flux. Forskolin‐stimulated Isc that is consistent with anion secretion was significantly reduced by basolateral but not apical application of Ba2+ and clofilium. Clotrimazole, a lipophillic compound also inhibited Isc in a concentration dependent manner. RT‐PCR demonstrated the presence of transcripts for SK3, Maxi‐K, Kv7.1, and KCNE1. Maxi‐K and Kv7.1 were localized to basolateral membrane using confocal microscopy confirming their expression at protein level. The above findings suggest that the clotrimazole sensitivity observed may be attributed to SK3 and Maxi‐K while clofilium sensitivity due to Kv7.1 and KCNE1. These data suggest that net ion transport in pig vas deferens epithelia requires the support of multiple K+ conductances. Targeted modulation of such potassium conductances could be useful in managing male fertility. Supported by NIH P20‐RR17686
Effect of Light and Moisture on Severity of Stemphylium Leaf Spot of Alfalfa (1982)

Determination des conditions de lumiere et d'humidite favorable a la reproduction en conditions controlees de la gravite et de l'apparition des symptomes de la maladie a tâches foliaires due a Stemphylium botryosum (biotype de basse temperature) sur la luzerne, telles qu'on les observe au champ en Californie
Tailoring Silica Surface Properties by Plasma Polymerization for Elastomer Applications (2011)

The surface properties of reinforcing fillers are a crucial factor for dispersion and filler–polymer interaction in rubber compounds, as they strongly influence the final vulcanized properties of the rubber article. Silica is gaining more and more importance as reinforcing filler for rubbers, as it allows for a reduction of rolling resistance and thus energy losses in tires, compared to the use of carbon black as filler. However, silica and common elastomers differ greatly in polarity and, therefore, are difficult to mix and thus have little interaction. In the present study plasma-coating of silica-filler with acetylene, thiophene and pyrrole is applied, and the surface-treated silicas are blended with S-SBR rubber, in an attempt to enhance the compatibility between the two. The dispersion and reinforcing effects of the modified silicas are investigated and compared with untreated and silanized silica. The relative rankings of the various coatings in reduction of filler–filler interaction, improved dispersion, enhanced polymer–filler interaction, apparent crosslink density and tensile mechanical properties are mutually different. Where the best silica dispersion and largest reduction in filler–filler interaction are obtained with polyacetylene coating and the worst with polythiophene coating, but the tensile properties achieved with the polythiophene coating are far better than all others. Apparently, the sulfur contained in the thiophene-moiety enhances the filler–polymer interaction and contributes to the degree of crosslinking. Unmodified silica performs worst in all aspects, also because its acidic nature harms the preferably alkaline vulcanization process. Silane treatment of silica has a positive effect on reduction of filler–filler interaction and improved dispersion, but has little effect on polymer–filler interaction in the still unvulcanized state. Its tensile properties after vulcanization are comparable with polyacetylene- or polypyrrole-coated silica. This investigation shows that the compatibility and interaction of silica with a polymer can be controlled by tailoring the surface energy of the filler by coating with plasma polymers. An appropriate monomer for the plasma polymerization process allows to improve the cured rubber properties.
Hepatic metastases of colorectal cancer are rather homogeneous but differ from primary lesions in terms of immune cell infiltration (2013)

The immune system plays an important role in shaping the clinical course of colorectal cancer (CRC). However, it is still unclear how the immune infiltrates of primary CRC lesions and distant metastases by immune effector cells are related to each other. To address this issue, we quantified CD3<sup>+</sup>, CD8<sup>+</sup> and granzyme B<sup>+</sup> lymphocytes in primary CRC samples and corresponding liver metastases. This analysis showed that the prognostic predictions that can be drawn from the infiltration of immune cells in primary CRCs and their metastases are heterogeneous. To investigate whether such heterogeneity would also be observed within CRC hepatic metastases, the density of the immune infiltrate and cytokine production were assessed in opposite sides of the same metastatic lesion. In addition, tumor-infiltrating lymphocytes were assessed in sequential sections of the same metastatic lesion, with a spacing of 30 μm. In summary, consistent cell counts and cytokine levels were detected within the same lesion. The study of a case of synchronous metastases, however, suggested that different metastatic lesions within the same patient may be heterogeneous, perhaps indicating a major impact for local causes on tumor infiltration by immune cells. In summary, our study demonstrates a consistent degree of heterogeneity between primary tumors and hepatic metastases but an excellent intra-lesional homogeneity. These findings may be of key importance for patient stratification and the development of personalized strategies against CRC.
Analyse critique du modèle immunologique du soi et du non-soi et de ses fondements métaphysiques implicites (2004)

An examination of the concepts used in immunology prompts us to wonder about the origins and the legitimacy of the notions of self and non-self, which constitute the core of the dominant theoretical model in this science. All theoretical reflection concerning immunology must aim at determining a criterion of immunogenicity, that is, an operational definition of the conditions in which an immune reaction occurs or does not occur. By criticizing both conceptually and experimentally the self/non-self vocabulary, we can demonstrate the inaccuracy and even the inadequacy of the dichotomy of self/non-self. Accordingly, the self/non-self model must be reexamined, or even rejected. On the basis of this critique, we can suggest an alternative theoretical hypothesis for immunology, based on the notion of continuity. The 'continuity hypothesis' developed here attempts to give a criterion of immunogenicity that avoids the reproaches leveled at the self model.
Slice-direction geometric distortion evaluation and correction with reversed slice-select gradient acquisitions (2022)

Accurate spatial alignment of MRI data acquired across multiple contrasts in the same subject is often crucial for data analysis and interpretation, but can be challenging in the presence of geometric distortions that differ between acquisitions. It is well known that single-shot echo-planar imaging (EPI) acquisitions suffer from distortion in the phase-encoding direction due to B<sub>0</sub> field inhomogeneities arising from tissue magnetic susceptibility differences and other sources, however there can be distortion in other encoding directions as well in the presence of strong field inhomogeneities. High-resolution ultrahigh-field MRI typically uses low bandwidth in the slice-encoding direction to acquire thin slices and, when combined with the pronounced B<sub>0</sub> inhomogeneities, is prone to an additional geometric distortion in the slice direction as well. Here we demonstrate the presence of this slice distortion in high-resolution 7T EPI acquired with a novel pulse sequence allowing for the reversal of the slice-encoding gradient polarity that enables the acquisition of pairs of images with equal magnitudes of distortion in the slice direction but with opposing polarities. We also show that the slice-direction distortion can be corrected using gradient reversal-based method applying the same software used for conventional corrections of phase-encoding direction distortion.
ChemInform Abstract: SYNTH. IN DER PURIN‐REIHE 27. MITT. DAS ADDITIONSPRODUKT VON PHOSPHOROXYCHLORID AN 2‐CHLOR‐3,7‐DIMETHYL‐HYPOXANTHIN (1973)

Abstract 2‐Chlor‐theobromin (I) und Phosphoroxychlorid reagieren bei 60‐80°C zu dem Salz (II), das mit Chlorwasserstoff zu dem Chlorid (III) umgesetzt wird.
Formal Models for Expert Finding on DBLP Bibliography Data (2008)

Finding relevant experts in a specific field is often crucial for consulting, both in industry and in academia. The aim of this paper is to address the expert-finding task in a real world academic field. We present three models for expert finding based on the large-scale DBLP bibliography and Google scholar for data supplementation. The first, a novel weighted language model, models an expert candidate based on the relevance and importance of associated documents by introducing a document prior probability, and achieves much better results than the basic language model. The second, a topic-based model, represents each candidate as a weighted sum of multiple topics, whilst the third, a hybrid model, combines the language model and the topic-based model. We evaluate our system using a benchmark dataset based on human relevance judgments of how well the expertise of proposed experts matches a query topic. Evaluation results show that our hybrid model outperforms other models in nearly all metrics.
RTL based scan BIST (2002)

The synthesis of ASICs from register transfer level (RTL) sources is often a bottom-up iterative process where the synthesis process is carefully controlled to produce a gate-level design which meets the desired constraints. Test logic, such as built-in self-test (BIST), is typically inserted at the gate level. This may cause new violations of timing/area goals, thus causing an expensive cycle of re-optimization on the complete chip at the end of the design process. Performing BIST logic insertion at the RTL source allows synthesis technology to consider test logic while optimizing to meet area/timing goals, thus avoiding an expensive re-optimization. It also provides an opportunity for the sharing of functional and test logic. Scan-based BIST utilizes scan chains to apply random vectors and to observe signal values within the random logic. This paper describes techniques for inserting scan chains at the RTL-VHDL source in the context of scan BIST, and reports its impact on design optimization and fault coverage.
Synthesis and characterization of PEG-silane functionalized iron oxide(II, III) nanoparticles for biomedical application (2015)

In this paper we report the synthesis, functionalization, and characterization of ferromagnetic iron oxide (II, III) nanoparticles with different shapes and sizes. Using a number of chemical methods, magnetite nanoparticles having a spherical shape and size of 9 ± 2 nm (coprecipitation), 22 ± 4 nm and 50 ± 6 nm (redox reaction), and 40 ± 5 nm cubes were synthesized. Special attention in this paper is devoted to the covalent modification of magnetite nanoparticles by polymers such as silane-polyethylene glycol (Peg-silane). The main advantage of magnetic nanoparticles modified by polymer is low toxicity, colloidal stability of the prepared magnetite nanoparticles, and the possibility for post functionalization. We determined coercivity and saturated magnetism. Also, the relaxivity T2 was measured by magnetic resonance imaging (MRI). Prepared nanoparticles are of great interest and potential for use in biomedical imaging.
Combinaison de caméras thermique et couleur pour la segmentation cibles/arrière-plan en environnement non contrôlé (2012)

La plupart des systèmes de surveillance vidéo que l’on retrouve actuellement sur le marché utilisent uniquement la région visible du spectre électromagnétique. De plus, les solutions proposées à ce jour afin de suivre automatiquement les objets en mouvement dans une scène sont souvent trop exigeantes numériquement pour pourvoir être effectuées en temps réel et présentent une dégradation significative des performances en environnement extérieur. L’objectif de cette thèse est d’exploiter la combinaison d’informations thermique et visible afin d’améliorer l’efficacité de détection et de suivi d’objets d’intérêt en environnement non contrôlé. Dans le cadre de ce projet, un seul nœud d’acquisition fixe est considéré. Un nœud est constitué d’une caméra thermique LWIR (8 - 12 m) et d’une caméra visible couleur. Trois défis techniques majeurs sont abordés : le développement d’une plateforme d’acquisition thermique / visible optimisée pour les applications de surveillance vidéo en environnement extérieur, la segmentation, en temps réel, d’objets en mouvement en environnement non contrôlé, et finalement, la combinaison de l’information thermique et couleur. Un intérêt soutenu est porté à la rapidité d’exécution afin d’atteindre une vitesse de traitement minimale de 10 trames par secondes. Il importe de mentionner que cette thèse a principalement été orientée selon les besoins du programme de Vision de l’INO, conférant ainsi un caractère très pratique et concret à la recherche. De ce fait, les algorithmes développés ont été continuellement testés et améliorés dans le cadre d'applications réelles. Les éléments relatifs à la mise en correspondance d'images thermique et visible ont permis le développement et la fabrication de le caméra VIRXCam, un produit offert par l'INO. Les algorithmes de détection constituent pour leur part le cœur du logiciel de surveillance vidéo AWARE, déjà utilisé depuis 2007 par un partenaire de l'INO s'intéressant au positionnement des objets en mouvement sur les pistes, voies de circulation et aires de stationnement d'aéroports. Cette thèse constitue un recueil très complet des éléments à considérer lors du développement d’une plateforme de vidéo surveillance en environnement extérieur. Tant les aspects matériels que logiciels sont traités. Nous espérons qu’elle constituera un ouvrage de référence pour les personnes qui s’intéressent au développement d’algorithmes temps réel pour des applications de détection de cibles en environnement non-contrôlé ou à la conception d’un capteur hybride thermique / visible.
Comparative proteomic characteristic of mycoplasmas (Mollicutes) (2011)

Saturating proteome identification and the study of post-translational protein modifications of Acholeplasma laidlawii using combination of single- and two-dimension gel electrophoresis followed by mass-spectrometry analysis have been carried out. Results were compared to the earlier identified proteome of Mycoplasma gallisepticum. It was found that M. gallisepticum and A. laidlawii express 61 and 58% of the annotated ORFs respectively. All subunits of DNA-polymerase III were identified during our study which indicates that our methods can detect single copies of a given protein per cell. Metabolic pathways of the respective mycoplasmas were compared further in this work.
Effect of Viscoelasticity of Vessel Walls on Pulse Wave (2010)

The pulse wave comes from the displacement of surface skin and is composed of incident and reflected waves. Since the properties of the reflected wave change considerably owing to the viscoelasticity of the vessel walls, the analysis of the reflected wave is considered to be useful for evaluating arterial stiffness; thereby, appropriate estimation of the incident wave is important for separating the pulse wave. Here, the incident wave is generated by a forward wave, which is the intravascular pressure caused by blood flow. In the former analysis, we assumed the blood vessel as an elastic tube and estimated the forward wave from the blood flow velocity waveform. In this study, we used a viscoelastic model to estimate a more appropriate forward wave. In this estimation, we used viscoelastic properties similar to those of bovine aorta, human aorta, or human artery. The estimated forward waves showed that the difference in the viscous properties of vessel walls causes minimal changes in the forward waves, which were also similar to that estimated using the elastic model. The result tells us that the elastic model is acceptable and useful for the estimation of forward wave, incident wave, and reflected wave, which enables the simple evaluation of the viscoelastic properties of vessel walls.
Combinatory repair strategy to promote axon regeneration and functional recovery after chronic spinal cord injury (2017)

Eight weeks post contusive spinal cord injury, we built a peripheral nerve graft bridge (PNG) through the cystic cavity and treated the graft/host interface with acidic fibroblast growth factor (aFGF) and chondroitinase ABC (ChABC). This combinatorial strategy remarkably enhanced integration between host astrocytes and graft Schwann cells, allowing for robust growth, especially of catecholaminergic axons, through the graft and back into the distal spinal cord. In the absence of aFGF+ChABC fewer catecholaminergic axons entered the graft, no axons exited, and Schwann cells and astrocytes failed to integrate. In sharp contrast with the acutely bridge-repaired cord, in the chronically repaired cord only low levels of serotonergic axons regenerated into the graft, with no evidence of re-entry back into the spinal cord. The failure of axons to regenerate was strongly correlated with a dramatic increase of SOCS3 expression. While regeneration was more limited overall than at acute stages, our combinatorial strategy in the chronically injured animals prevented a decline in locomotor behavior and bladder physiology outcomes associated with an invasive repair strategy. These results indicate that PNG+aFGF+ChABC treatment of the chronically contused spinal cord can provide a permissive substrate for the regeneration of certain neuronal populations that retain a growth potential over time, and lead to functional improvements.
Supplementary Figure 4 from Novel ATP-Competitive MEK Inhibitor E6201 Is Effective against Vemurafenib-Resistant Melanoma Harboring the MEK1-C121S Mutation in a Preclinical Model (2023)

&lt;p&gt;PDF - 86K, Cleavaged -PARP induction in A375 and G361 parental cells.&lt;/p&gt;