gebhart/patrepeval huggingface dataset:
Tricyclic antidepressants and histamine H1 receptors. (1979)

Tricyclic antidepressants and some structurally related compounds were tested for their ability to antagonize histamine H1 and muscarinic acetylcholine receptors of cultured mouse neuroblastoma cells. As a group, tertiary amine tricyclic antidepressants tended to be more potent than secondary amine drugs at both receptors. The most potent antihistamine, doxepin hydrocholoride, was about 4 times more potent than amitriptyline hydrochloride, about 800 times more potent than diphenhydramine hydrochloride, and about 8,000 times more potent than desipramine hydrochloride, the least potent tricyclic antidepressant at both the histamine H1 and the muscarinic acetylcholine receptors. All tricyclic drugs except desipramine hydrochloride were more potent as antihistamines than as anticholinergics. Doxepin hydrochloride and amitriptyline hydrochloride may be the most potent antihistamines known, and the antihistaminic potencies of these and the other tricyclic antidepressant drugs may relate directly to their ability to cause sedation and drowsiness in patients.
Internetworking LANs and WANs: Concepts, Techniques and Methods (1993)

Network Concepts. Local Area Networks. Local Area Networking. Constructing Local Area Networks. Wide Area Networks and Network Facilities. Network Layer Operations. Bridging Methods. Routers. Gateway Functions, Methods and Applications. Network Security. vLANs and Virtual Networking. Performance Issues. Index.
Post-Synthetic Enzymatic and Chemical Modifications for Novel Sustainable Polyesters (2022)

Because of their biodegradability, compostability, compatibility and flexible structures, biodegradable polymers such as polyhydroxyalkanoates (PHA) are an important class of biopolymers with various industrial and biological uses. PHAs are thermoplastic polyesters with a limited processability due to their low heat resistance. Furthermore, due to their high crystallinity, some PHAs are stiff and brittle. These features result sometimes in very poor mechanical characteristics with low extension at break values which limit the application range of some natural PHAs. Several <i>in vivo</i> approaches for PHA copolymer modifications range from polymer production to enhance PHA-based material performance after synthesis. The methods for enzymatic and chemical polymer modifications are aiming at modifying the structures of the polyesters and thereby their characteristics while retaining the biodegradability. This survey illustrates the efficient use of enzymes and chemicals in post-synthetic PHA modifications, offering insights on these green techniques for modifying and improving polymer performance. Important studies in this sector will be reviewed, as well as chances and obstacles for their stability and hyper-production.
Metamaterial enhanced phased-array antenna (2013)

In this work, different approaches for enhancing radiation properties of phased-array antennas based on metamaterials (MTM) are presented. In case of antenna front-end technology, efforts have been done in designing metaradomes for mitigation of the blind-spot effect inherent to the periodic structure of phased arrays and in designing a compact series feeding network.
Experimental validation of a new heterogeneous mechanical test design (2018)

Standard material parameters identification strategies generally use an extensive number of classical tests for collecting the required experimental data. However, a great effort has been made recently by the scientific and industrial communities to support this experimental database on heterogeneous tests. These tests can provide richer information on the material behavior allowing the identification of a more complete set of material parameters. This is a result of the recent development of full-field measurements techniques, like digital image correlation (DIC), that can capture the heterogeneous deformation fields on the specimen surface during the test. Recently, new specimen geometries were designed to enhance the richness of the strain field and capture supplementary strain states. The butterfly specimen is an example of these new geometries, designed through a numerical optimization procedure where an indicator capable of evaluating the heterogeneity and the richness of strain information. However, no experimental validation was yet performed. The aim of this work is to experimentally validate the heterogeneous butterfly mechanical test in the parameter identification framework. For this aim, DIC technique and a Finite Element Model Up-date inverse strategy are used together for the parameter identification of a DC04 steel, as well as the calculation of the indicator. The experimental tests are carried out in a universal testing machine with the ARAMIS measuring system to provide the strain states on the specimen surface. The identification strategy is accomplished with the data obtained from the experimental tests and the results are compared to a reference numerical solution.
Revision Carpal Tunnel Release: Risk Factors and Rate of Secondary Surgery (2020)

Risk, III.
Textile-based washable polymer solar cells for optoelectronic modules: toward self-powered smart clothing (2019)

Innovative textile-based washable polymer solar cells are realized by suppressing the hydrolysis of the encapsulation barrier with a SiO<sub>2</sub>–polymer composite.
Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA. (1988)

The replication of simian virus 40 (SV40) DNA is largely dependent upon cellular replication proteins. To define these proteins we have made use of a cell-free system that is capable of replicating plasmid DNA molecules containing the SV40 origin of replication. Systematic fractionation-reconstitution experiments indicate that there are a minimum of six cellular proteins that are required for efficient viral DNA replication in vitro. We report here the purification of one of these proteins, replication protein A (RP-A), to homogeneity. RP-A is a multisubunit protein that contains four tightly associated polypeptides of 70, 53, 32, and 14 kDa. Partial proteolysis experiments indicate that the 53-kDa polypeptide is closely related to the 70-kDa polypeptide, suggesting that it may be a proteolytic fragment of the larger subunit. RP-A is absolutely required for reconstitution of SV40 DNA replication in vitro. The purified protein binds to single-stranded DNA and is required for the large tumor (T)-antigen-mediated unwinding of DNA molecules containing the SV40 origin of DNA replication. These properties are consistent with the possibility that RP-A plays a central role in the generation of a single-stranded region at the origin prior to initiation of DNA synthesis. The protein may also function to facilitate unwinding of the parental DNA strands during the elongation phase of SV40 DNA replication.
Identification of fatty acid methyl esters as minor components of fish oil by multidimensional GC‐MSD: New furan fatty acids (1994)

Abstract The separation and analysis of furan fatty acids and other minor component fatty acids present at very low concentrations in complex sample matrices, such as fish oil or lipids derived from liver and testes, require several pre‐analytical separation steps if single column gas chromatography is to furnish sufficient resolution: after extraction and transesterification hydrogenation, urea complex precipitation and argentation TLC have been applied prior to GC analysis of furan fatty acids. By using multidimensional GC‐MSD with cooled injection and flow‐controlled column switching with intermediate cold trapping, it has been possible to identify directly the methyl esters of furan fatty acids without further pre‐analytical separation. The most common of the furan fatty acids can be subdivided into two groups depending on whether they bear a propyl or pentyl side group in the 5‐position of the furan ring. In addition to the eight furan fatty acids known to be present in fish oil, six new ones were identified, four with propyl substitution and two with pentyl substitution. Four have earlier been reported to be present in the hepatopancreas of crayfish and in fish tissue, whereas the propyl‐substituted 16,19‐epoxy‐17,18‐dimethyldocosa‐16,18‐dienoic acid and the pentyl‐substituted furan fatty acid 6,9‐epoxy‐7‐methyltetradeca‐6,8‐dienoic acid were hitherto unknown.
Design of W-band VCOs with high output power for potential application in 77 GHz automotive radar systems (2003)

It is demonstrated that SiGe bipolar preproduction technologies are well suited for VCOs in 77 GHz automotive radar systems. Due to the relatively high output power aimed at, the designer has to consider the physical transistor limits carefully. The VCOs need a single supply voltage only and have been fully integrated (including resonant circuit and output buffer) on a single small (1 mm/sup 2/) chip, demonstrating their low-cost potential. First experimental results based on a not fully optimized design showed at a center frequency of about 77 GHz, a tuning range of 4.3 GHz, and a phase noise of -95 dBc/Hz at 1 MHz offset frequency. The total signal power of both outputs is 14.3 dBm. Simulations demonstrate a further potential increase of total output power (for two or four outputs) by about 5 dBm.
Immunoperoxidase technique in histopathology: applications, methods, and controls. (1979)

With its diversity of possible Umwelten or environments for living things, Jakob von Uexküll’s Umwelt theory has been hailed by many readers as the first step toward an innovative, pluralistic conception of nonhuman life. But what is generally ignored is its structural conservatism, its identitarian logic in which everything should remain in its place and nothing should mix, and its proximity to Nazi ideology and politics. By turning the spotlight on these neglected aspects, Uexküll’s Surroundings opens up a new perspective on Uexküll’s Umwelt theory.\n
Designing data entry programs using state diagram as a common model (1982)

A minicomputer based data entry system recently developed at Bell Laboratories supports 73 transaction types and approximately 1000 fields. The user communicates with the system from a CRT terminal in field-by-field mode via a uniform interface. This paper presents a common design for the family of data entry programs that process the various types of transactions. The design is represented by a compact, orderly, and verifiable model to demonstrate the consistent program behavior. The model is formalized and proved correct to validate the design. The common model reduces design effort, provides design generality, enables code generation, and enhances ease of maintenance. The correctness proof eliminates high level design errors and their consequences. In the general area of business application, a common design lends itself to quickly mass produce components of a software product, and makes it easy to maintain them later.
A TDC-based 4&#x00D7;128 CMOS SPAD array for time-gated Raman spectroscopy (2014)

A 4×128 CMOS SPAD array has been designed and tested for a time-gated Raman spectroscopy. The SPAD array includes a 3-bit TDC for each of the SPAD elements (512). The TDC is designed to have 78 ps resolution in the first four bins for the accurate time position measurement of the Raman photons. The resolution is degraded for the last four bins used for fluorescence and background correction to achieve larger dynamic range. The timing skew of the bins of the TDC along spectral axis was measured to be ± 70 ps with 7 ps variation (sigma) in the bin widths.
Total Synthesis of 10-Isocyano-4-cadinene and Its Stereoisomers and Evaluations of Antifouling Activities (2011)

The first enantioselective total synthesis of 10-isocyano-4-cadinene, a marine sesquiterpene isolated from nudibranchs of the family Phyllidiidae, and determination of its absolute stereochemistry were achieved. 10-Isocyano-4-cadinene is expected to be a novel nontoxic antifouling agent. In the synthesis, intermolecular Diels-Alder reaction and samarium diiodide induced Barbier-type cyclization were employed as key steps. The absolute configuration of 10-isocyano-4-cadinene was determined as (1S,6S,7R,10S) by comparison of the optical rotations between natural and synthetic samples. In addition, the authors successfully synthesized 10-epi- and di-1,6-epi-10-isocyano-4-cadinene through the same synthetic pathway. Antifouling activities against Balanus amphitrite with the cadinenes were also evaluated.
The interactive effects of simultaneous biotic and abiotic stresses on plants: Mechanistic understanding from drought and pathogen combination (2014)

In nature, plants are simultaneously exposed to a combination of biotic and abiotic stresses that limit crop yields. Only recently, researchers have started understanding the molecular basis of combined biotic and abiotic stress interactions. Evidences suggest that under combined stress plants exhibit tailored physiological and molecular responses, in addition to several shared responses as part of their stress tolerance strategy. These tailored responses are suggested to occur only in plants exposed to simultaneous stresses and this information cannot be inferred from individual stress studies. In this review article, we provide update on the responses of plants to simultaneous biotic and abiotic stresses, in particular drought and pathogen. Simultaneous occurrence of drought and pathogen during plant growth provokes complex pathways controlled by different signaling events resulting in positive or negative impact of one stress over the other. Here, we summarize the effect of combined drought and pathogen infection on plants and highlight the tailored strategies adapted by plants. Besides, we enumerate the evidences from pathogen derived elicitors and ABA response studies for understanding simultaneous drought and pathogen tolerance.
ChemInform Abstract: SYNTHESES AND DIURETIC ACTIVITY OF 1,2‐DIHYDRO‐2‐(3‐PYRIDYL)‐3H‐PYRIDO(2,3‐D)PYRIMIDIN‐4‐ONE AND RELATED COMPOUNDS (1982)

Abstract Die Carbonsäure (I) ergibt durch Veresterung, Ammonolyse und Cyclisierung die im Titel genannte Verbindung (II).
Tetrapyrrolic Glycosylated Macrocycles for an Application in PDT (1999)

The synthesis and characterization of amphiphilic glycoconjugated porphyrins, benzochlorin, and azaporphyrins were reported. Among these molecules, several were found to be efficient photosensitizers in an in vitro assay using the human tumoral cell line HT29. Moreover, glycosylated benzochlorin and azaporphyrins, whose absorption bands in the red region of the visible spectrum are substantially increased as compared to porphyrins, display a good photocytotoxicity on tumor cells after irradiation with wavelength above 590 nm. © 1999 Society of Photo-Optical Instrumentation Engineers.
Characterization of methane emissions from five cold heavy oil production with sands (CHOPS) facilities (2018)

Methane measurements from cold heavy oil production with sand (CHOPS) sites identify annular venting to be a potentially major source of emissions at these facilities. The measured emission rates are generally larger than reported by operators, with uncertainty in the gas-oil ratio (GOR) possibly playing a large role in this discrepancy. These results have potential policy implications for reducing methane emissions in Alberta in order to achieve the Canadian government's goal of reducing methane emissions by 40-45% below 2012 levels within 8 yr.
Graphene electronics for RF applications (2011)

Graphene, a one-atom-thick layer of carbon atoms arranged in a honeycomb lattice, has recently attracted great interest among physicists and engineers. The combination of the unique properties of this material, with new device concepts and nanotechnology may overcome some of the main limitations of traditional radio-frequency (RF) electronics in terms of maximum frequency, linearity and power dissipation. In this paper, we review the recent progress on graphene-based electronic devices for RF applications. In particular, the growth and technology of graphene transistors with an f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> .L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G</sub> product of 24 GHz.μm will be discussed. These devices have shown excellent potential for high speed RF applications and frequency multiplier circuits with cut-off frequencies of more than 1.4 GHz have been demonstrated. The future challenges facing this rising technology and its feasibility for a new generation of applications in RF communications and circuits are also discussed.
Identification of trans-splicing sites in Leishmania major using probabilistic methods (2007)

Leishmania major, a member of the Kinetoplastida family, is a primitive protozoan that causes a human disease, called leishmaniases, affecting numerous people worldwide. The identification of new drug targets to combat leishmaniases necessitates a thorough understanding of how genomic instructions are transformed into functional proteins. It requires not only the prediction and categorization of all the genes, but also a profound understanding of their regulation. Much of gene regulation may occur through a process known as frarcs-splicing. Trans-splicing, which is mechanistically similar to cissplicing, is the process of cleaving a large polycistronic transcript into smaller monocistronic components.\nThe goal of this project was to establish a model to accurately predict sites where /rans-splicing occurs. After carefully analyzing the data set, a second-order log odds ratio model was created. This method achieved an overall accuracy of 89% in predicting transsplice sites.\nFurthermore, this new method has been applied to a small data set with alternative trans-splice sites. Of the 70 EST-indicated alternative frans-splice sites 60 were identified as such. This represents the first computational method for the prediction of alternative splice sites. In addition, we have found the first real evidence for the branch point signal which plays an essential role in the ^raws-splicing process.
Study on a stitching algorithm of the iterative closest point based on dynamic hierarchy (2015)

In order to improve the efficiency of matching marked points, the accuracy and automation of point cloud stitching, a stitching algorithm of dynamic hierarchy of the iterative closest point is proposed. First, the dynamic distance matrix was introduced to record the distance of hierarchical searching marked point; to complete the coarse stitching, the marked point was matched through the dynamic distance matrix and the least square method was used to resolve the transformation matrix. Second, at the stage of precisely stitching dynamic hierarchical search points a set was taken to initialize a valid initial position for the iterative closest point algorithm, then the local optimum of the iterative closest point algorithm was avoided. In a three-dimensional stitching experiment the precise stitching distance error has reached 0.0085 mm; the method is testified to be simple, practical and characterized by high stitching precision.
Performance of multirate techniques in W-CDMA (2002)

We analyze and compare the error performances of two multirate transmission schemes in W-CDMA: multicode (MCD) and variable spreading gain (VSG). First, we show that in an AWGN channel, the VSG data user performs better than the MCD user if the number of in-cell voice users are low and the background noise is weak. However, as the noise power or the number of voice subscribers increases, the performances of the two schemes become similar. We then show that in a multipath fading channel, the two schemes achieve very similar error performances as long as their receivers are able to track all resolvable signal paths. However, when the receiver can only track multipath components within the current symbol interval, the VSG user yields a much worse error probability than the MCD user. This is because the VSG data user has a much shorter symbol interval. Simulation results are illustrated to support the analysis.
Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC (2017)

: The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outside the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. This noise level is significantly lower than previous experiments utilizing warm front-end electronics.
ROMPgel Beads in IRORI Format:  Acylations Revisited (2004)

Functionalized "designer" polymers derived from ring-opening metathesis polymerization (ROMPgels) are attractive for their high loading, high purity, and ease of synthesis. Their physical state may vary from liquid to gel to granular solid, making a general method of handling these polymers difficult. By incorporating a suitable norbornene-substituted linker on standard Wang beads, ROMPgels can be easily grafted onto the resin, adding the convenience of a bead format while still maintaining the high loading and excellent site accessibility. This advantage is demonstrated by the use of an N-hydroxysuccinimide ROMPgel (3.3 mmol g(-1), a 3-fold increase from the parent linker resin) in IRORI Kan format. Conditions for the acylation of these IRORI-formatted ROMPgels are reported, along with the scope and limitations of the choice of acylating reagents. Yields are greatly improved by the use of perfluorinated solvents as a nonparticipating cosolvent in the acylation process. A simple titration method for the quantification of the acylated ROMPgels is also reported. Spent Kans are regenerated after each use without apparent loss of activity or purity after several cycles. Due to the high loading and reduced swelling of the ROMPgel resin, up to 0.39 mmol acyl group has successfully been recovered from a single IRORI miniKan, demonstrating the high capacity of the resin and applicability to both lead discovery and optimization programs.