gebhart/patrepeval huggingface dataset:
Composite assessment of treatment response in patients (pts) with locally advanced basal cell carcinoma (laBCC): Sonidegib efficacy using two sets of response criteria. (2015)

e20055 Background: In the pivotal BOLT phase 2 study (NCT01327053), durable responses were observed in pts with advanced BCC treated with sonidegib, a hedgehog pathway inhibitor (HPI). Treatment responses were assessed using a novel composite evaluation, which was more stringent than that used in prior studies of HPIs in BCC. In this analysis, treatment responses in BOLT were evaluated using 2 sets of criteria: BCC-mRECIST (A; used in BOLT) and BCC-mRECIST-like (B; similar to criteria used in other HPI studies with less stringent requirements for complete response [CR]). Methods: Assessments by MRI per RECIST v1.1, photography per WHO guidelines, and histology in multiple biopsies were used to determine a composite overall response (COR) in pts with laBCC treated with sonidegib 200 mg once daily (QD) using criteria A and B. The main distinction between A and B was the level of stringency required to achieve a COR of CR. Criteria B allowed a COR of CR when the response by MRI and/or photography was partial (PR) or stable disease (SD), as long as the histology result was negative; in contrast, in the same cases, COR by criteria A was considered a PR. Objective response rate (ORR), best overall response (BOR), and disease control rate (DCR; CR + PR + SD) were assessed by central review using both criteria. Results: The ORR and DCR were similar with both criteria (Table), but the CR rate was higher with criteria B than with A (20% vs 5%). Conclusions: These data demonstrate a high response to sonidegib and the stringency of the BCC-mRECIST criteria used in BOLT.The higher CR rate with the BCC-mRECIST-like criteria observed in this analysis was due to the less stringent requirement for a COR of CR (ie, negative histology can overrule MRI/photography data that indicate residual disease). Despite the inherent challenges of assessing tumor response in laBCC, both evaluation criteria support the clinical benefit of sonidegib in this difficult-to-treat pt population. Clinical trial information: NCT01327053.Efficacy of sonidegib 200 mg QD in pts with laBCC (n = 66)a Criteria A B ORR, % 58 62 95% CI 45-70 49-74 BOR, % CR 5 20 PR 53 42 SD 33 29 Progressive disease 2 2 Unknown 8 8 DCR, % 91 91 a 12-mo data; cutoff: Dec 31, 2013; median follow-up: 20 mo.
Fibroblast Growth Factor-10 (1999)

Fibroblast growth factor (FGF)-10, a homologue of FGF-7, is expressed significantly in normal rat prostate tissue, well differentiated rat prostate tumors with an epithelial and stromal compartment and only in derived prostate stromal cells in culture. Similar to FGF-7, recombinant rat FGF-10 was a specific mitogen for prostate epithelial cells. In contrast to FGF-7 which is widely expressed among stromal cells in tissues, the expression of FGF-10 correlated with the presence of stromal cells of muscle origin. Radioreceptor binding assays and covalent cross-linking analysis revealed that FGF-10 binds with an affinity equal to FGF-7 to resident epithelial cell receptor, FGFR2IIIb, but unlike FGF-7 also binds the IIIb splice variant of FGFR1. Analysis of mRNA expression by RNase protection revealed that, similar to FGF-7, the expression of FGF-10 was responsive to androgen in stromal cells from normal prostate and non-malignant differentiated tumors. Although FGF-10 cDNA exhibits a signal sequence for secretion, cultured stromal cells exhibit strictly a cell-associated FGF-10 antigen that correlates with an alternately translated intracellular isoform. FGF-10 requires 1.4 times higher NaCl for elution from immobilized heparin than does FGF-7 and binds to four times the number of sites on the pericellular matrix of epithelial cells. The results show that prostate stromal cell-derived FGF-10, like FGF-7, exhibits the properties of an andromedin which may indirectly mediate control of epithelial cell growth and function by androgen. Although FGF-10 and FGF-7 bind and activate the same resident epithelial cell receptor (FGFR2IIIb), differences in cell type of origin, compartmentation by alternate translation, the affinity for FGFR1IIIb, and access to FGFR by differential interaction with pericellular matrix heparan sulfate suggest they may play both independent and compensatory roles in prostate homeostasis.
Anti-Selective [3+2] (Hetero)annulation of Non-Conjugated Alkenes via Directed Nucleopalladation (2020)

2,3-Dihydrobenzofurans and indolines are common substructures in medicines and natural products. Herein, we describe a method that enables direct access to these core structures from non-conjugated alkenyl amides and &lt;i&gt;ortho&lt;/i&gt;-iodoanilines/phenols. Under palladium(II) catalysis this [3+2] heteroannulation proceeds in an &lt;i&gt;anti&lt;/i&gt;-selective fashion and tolerates a wide variety of functional groups. &lt;i&gt;N&lt;/i&gt;-Acetyl, -tosyl, and -alkyl substituted &lt;i&gt;ortho&lt;/i&gt;-iodoanilines, as well as free –NH&lt;sub&gt;2&lt;/sub&gt; variants, are all effective. Preliminary results with carbon-based coupling partners also demonstrate the viability of forming indane core structures using this approach. Experimental and computational data with phenols support a mechanism involving turnover-limiting, endergonic directed oxypalladation, followed by intramolecular oxidative addition and reductive elimination.
Interference-avoidance pilot design using ZCZ sequences for multi-cell MIMO-OFDM systems (2012)

In this paper, we propose an interference-avoidance pilot design scheme using Zero-Correlation Zone (ZCZ) sequences for multi-cell MIMO-OFDM systems. In the proposed scheme, the ZCZ sequences from the same family set are designed as the time-domain (TD) pilot symbols and are Code-Division Multiplexing (CDM) for different transmit antennas in adjacent cells. Due to the perfect auto-correlation and cross-correlation properties of the ZCZ sequences within a certain correlation zone that is designed equal to or a little larger than the Cyclic Prefix (CP) length, the inter-cell interference of the pilot symbols can be effectively eliminated by utilizing a time-domain correlation-based channel estimation method. Simulation results show that the proposed scheme achieves near optimal normalized Mean Square Error (MSE) performance of channel estimation in a multi-cell environment.
Networking issues in IP multicast over satellite (2003)

Abstract This paper describes the issues that arise when using satellites for IP multicast, with the emphasis on multicast protocols and how their implementation depends on the satellite communications platform. Various link layer standards such as DVB‐S, DVB‐RCS and ATM can be used in satellites with on‐board processing, and applied to meet user and network requirements for IP multicast. The paper provides an overview of the networking issues and their interactions. Specifically, we show how multicast networking protocols have to be modified to take into account the satellite link characteristics: these protocols include IGMP, multicast routing protocols and reliable multicast protocols. We also discuss how security systems support IP multicast. Copyright © 2003 John Wiley &amp; Sons, Ltd.
pH: Keyfactor in the Biological Phosphorus Removal Process (1994)

Experiments have been performed, using a sequencing batch reactor, to examine the effect of pH on biological phosphorus removal in the activated sludge process. The results, which indicate that glycogen metabolism occurs during anaerobic conditions, are useful in elucidating the biochemical mechanisms involved in phosphorus-removal, and have potential implications for systems such as Phostrip.
Humidity driven molecular switch based on photoluminescent DyIIICoIII single-molecule magnets (2019)

Functional materials incorporating cyanido-bridged Dy<sup>III</sup>Co<sup>III</sup> molecules combine visible photoluminescence and slow magnetic relaxation, both switchable by the level of humidity within the reversible room temperature dehydration process.
Recommending books of revealed and latent interests in e-commerce (2002)

We describe TwinFinder: a recommender system for an on-line bookstore. For developing TwinFinder, we extend the capability of conventional content-based recommendation by two novel methods: the Order-Matching Method (OMM) and the Cross-Matching Method (CMM). OMM and CMM aim to provide information of customers' revealed and latent interest, respectively. Thus, TwinFinder is able to discover new chances to sell books by CMM, while by OMM the system recommends books on customers' revealed interests. We have implemented and validated TwinFinder in the e-business system of a bookstore in Japan.
Loss of Polarization Entanglement in Optical Fibers due to Polarization Mode Dispersion (2010)

We perform quantum tomography measurements on polarization-entangled photon pairs traversing fibers with birefringence. We find that the entanglement disappears gradually if the birefringence affects only one photon of the pair. A theory supports our observations.
Electrospun Ca 3 Co 4− x O 9+ δ nanofibers and nanoribbons: Microstructure and thermoelectric properties (2022)

Abstract Oxide‐based ceramics offer promising thermoelectric (TE) materials for recycling high‐temperature waste heat, generated extensively from industrial sources. To further improve the functional performance of TE materials, their power factor should be increased. This can be achieved by nanostructuring and texturing the oxide‐based ceramics creating multiple interphases and nanopores, which simultaneously increase the electrical conductivity and the Seebeck coefficient. The aim of this work is to achieve this goal by compacting electrospun nanofibers of calcium cobaltite Ca 3 Co 4− x O 9+ δ , known to be a promising p‐type TE material with good functional properties and thermal stability up to 1200 K in air. For this purpose, polycrystalline Ca 3 Co 4− x O 9+ δ nanofibers and nanoribbons were fabricated by sol–gel electrospinning and calcination at intermediate temperatures to obtain small primary particle sizes. Bulk ceramics were formed by sintering pressed compacts of calcined nanofibers during TE measurements. The bulk nanofiber sample pre‐calcined at 973 K exhibited an improved Seebeck coefficient of 176.5 S cm −1 and a power factor of 2.47 μW cm −1 K −2 similar to an electrospun nanofiber‐derived ceramic compacted by spark plasma sintering.
EuroTrough Design Issues and Prototype Testing at PSA (2001)

Abstract A parabolic trough collector has been developed for various applications in the 200–400°C temperature range in solar fields up to the hundreds Megawatts range. The design of a new support structure of the collector included concept studies, wind tunnel measurements, finite elements method (FEM) analyses and resulted in a structure with a central framework element. This torque box design will have lower weight and less deformation of the collector structure than the other designs considered. Therefore it will be possible in future to connect more collector elements on one drive which results in reduced total number of drives and interconnecting pipes, thus reducing the installation cost and thermal losses. In terms of the degree of material usage further weight reduction will be possible. The presented design has a significant potential for cost reduction, the most important goal of the EuroTrough project. The prototype has been set-up and is under testing at PSA (Plataforma Solar de Almería) for its thermal and mechanical properties.
Lithium-Ion Battery Separator Prepared by Double-Matrix Encapsulation and Penetration (2021)

A new lithium-ion battery separator and preparation method are proposed based on double-matrix encapsulation and penetration (DMEP). A coaxial nozzle was used to control the output of solutions with a certain ratio of injection rates, and DMEP was realized after spinning. The conflict between high porosity and strong tensile properties of the membrane was solved in one step. The PAN matrix is encapsulated on the fiber surface, and the DMEP membrane exhibits better surface wettability, electrolyte uptake (473.1%), and porosity (65.3%). Moreover, the tensile strength and strain until the fracture of the membrane were increased by almost 142% and 75%, respectively. This result was based on the irregular mutual penetration of the double matrixes (PAN and PVA) of the fiber and the multipoint bonding between the fibers. The DMEP membrane also shows excellent ionic conductivity (1.77 mS cm–1), thermal stability (270 °C), and electrochemical performance. The good mechanical properties, ionic conductivity, and electrochemical properties clearly indicate the potential of using PAN/PVA DMEP composite separators in lithium-ion batteries.
DEVELOPMENT OF SPECIALY DESIGNED "6R" CONSTRUCTION PRODUCTS (2016)

After years of neglecting our future being today, we are witnessing the 6th wave of innovation where sustainability, industrial ecology, renewable energy and green nanotechnology are main postulates. Thanks to the significant changes in technological processes, which assured transformation of undesirable waste to a valuable resource, idea of using performance based materials is finally coming to life. Unfortunately, regulations still do not allow adjustment to locally available materials and rather insist on large safety factors instead of the engineering logic. Small steps are done with 7th basic requirement for construction, where the reuse or recyclability of the construction materials, durability and use of environmentally compatible raw and secondary materials in the construction works are emphasized. Due to the fact that concrete is produced locally with short transportation routes, environmental requirements can easily be satisfied. To assure further decrease of CO2 emissions and energy consumption, different alternative materials, mostly by-products of other industries, are used as binders, aggregates or reinforcement. Within this paper, innovative concrete products developed at Department of Materials of the University of Zagreb Faculty of Civil engineering will be presented.
Multiple Forms of Rice Seeds β-Amylases on Zymogram (1975)

Journal Article Multiple Forms of Rice Seeds β-Amylases on Zymogram Get access Hirokazu Matsui, Hirokazu Matsui Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo Search for other works by this author on: Oxford Academic Google Scholar Seiya Chiba, Seiya Chiba Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo Search for other works by this author on: Oxford Academic Google Scholar Tokuji Shimomura, Tokuji Shimomura Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo Search for other works by this author on: Oxford Academic Google Scholar Nobuyuki Takahashi Nobuyuki Takahashi Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo Present address: Tokyo Tanabe Parmaceutical Co., Ltd. Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 39, Issue 11, 1 November 1975, Pages 2239–2240, https://doi.org/10.1080/00021369.1975.10861938 Published: 01 November 1975 Article history Received: 21 April 1975 Published: 01 November 1975
Role of Mechanotransduction in Vascular Biology (2015)

Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture are influenced by the hemodynamic loads and mechanical properties of the wall. We have only limited understanding, however, of the mechanobiological processes that lead to these potentially lethal conditions. Homeostasis requires that intramural cells sense their local chemomechanical environment and establish, maintain, remodel, or repair the extracellular matrix to provide suitable compliance and yet sufficient strength. Proper sensing, in turn, necessitates both receptors that connect the extracellular matrix to intracellular actomyosin filaments and signaling molecules that transmit the related information to the nucleus. Thoracic aortic aneurysms and dissections are associated with poorly controlled hypertension and mutations in genes for extracellular matrix constituents, membrane receptors, contractile proteins, and associated signaling molecules. This grouping of factors suggests that these thoracic diseases result, in part, from dysfunctional mechanosensing and mechanoregulation of the extracellular matrix by the intramural cells, which leads to a compromised structural integrity of the wall. Thus, improved understanding of the mechanobiology of aortic cells could lead to new therapeutic strategies for thoracic aortic aneurysms and dissections.
Stressed Cells Cope with Protein Overload (2006)

Stress on eukaryotic cells causes build-up of unfolded proteins in the endoplasmic reticulum. To protect itself, the cell degrades mRNA for ER proteins.
Convective equilibrium and mixing-length theory for stellarator reactors (1987)

In high 0 stellarator and tokanak reactors, the plasma pressure gradient in some regions of the plasma may exceed the critical pressure gradient set by ballooning instabilities.In these regions, convective cells break out to enhance the transport-As a result, the pressure gradient can rise only slightly above the critical gradient and the plasma is in another state of equilibrium -"connective equilibrium" -in these regionsi Although the convective transport cannot be calculated precisely, it is shown that the density and temperature profiles in the convective region can.still be estimated.A simple mixing-length theory, similar to that used for convection in stellar interiors, is introduced in this paper to provide a qualitative description of the convective cells and to show that the convective transport is highly efficient.A numerical example for obtaining the density and temperature profiles in a 3tellarator reactor is DISCLAIMERgiven.
A routine flat embedding method for electron microscopy of microorganisms allowing selection and precisely orientated sectioning of single cells by light microscopy (1983)

A simple method is described to embed material in resin, in the form of microscope slides, to observe it with high resolution light microscopy, to select, orient and section it for TEM. This method can be applied to many kinds of material but is particularly useful for the study of rare or tiny plant or animal microorganisms from field or culture. A diamond scriber, translucent hydrosoluble resin release agent, translucent and smooth resin stubs and a longitudinally perforated block-holder for ultramicrotome are the specific tools of this method.
Perturbation of neutron dose distributions by lung tissue (1974)

The influence of lung tissue on depth dose distributions, produced by beams of fast neutrons (generated at the Naval Research Laboratory cyclotron by bombarding a thick Be target with 35‐MeV deuterons) was determined. Muscle‐equivalent ionization chambers were utilized in conjunction with thermoluminescent dosimeters to establish the neutron and gamma ray‐dose deposited in a phantom of the thoracic region of the body containing lung components. All irradiations were carried out at a target–skin distance of 125 cm with neutron beams of 10 × 10‐cm field size at the surface of the phantom. From these measurements, the authors conclude that the presence of lung tissue results in higher dose levels for points at depths greater than the midpoint of the lungs as a result of the increased transmission of neutrons by low‐density lung tissue. An examination of the dose measurements revealed that the portion of the total dose due to gamma rays is of the order of 4–10% for points in lung and muscle‐equivalent fluid.
Mining electronic medical records for patient care patterns (2009)

A novel approach for generating full Electronic Medical Records of synthetic victims is described. Special emphasis is put on the data mining steps that build patient care models and perform clustering of this highly dimensional data set. A methodology for cluster validation is proposed. Results for a large data set with Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus infections are presented.
Uncovering Trait Associations Resulting in Maximal Seed Yield in Winter and Spring Oilseed Rape (2021)

Seed yield is a complex trait for many crop species including oilseed rape (OSR) (<i>Brassica napus</i>), the second most important oilseed crop worldwide. Studies have focused on the contribution of distinct factors in seed yield such as environmental cues, agronomical practices, growth conditions, or specific phenotypic traits at the whole plant level, such as number of pods in a plant. However, how female reproductive traits contribute to whole plant level traits, and hence to seed yield, has been largely ignored. Here, we describe the combined contribution of 33 phenotypic traits within a <i>B. napus</i> diversity set population and their trade-offs at the whole plant and organ level, along with their interaction with plant level traits. Our results revealed that both Winter OSR (WOSR) and Spring OSR (SOSR); the two more economically important OSR groups in terms of oil production; share a common dominant reproductive strategy for seed yield. In this strategy, the main inflorescence is the principal source of seed yield, producing a good number of ovules, a large number of long pods with a concomitantly high number of seeds per pod. Moreover, we observed that WOSR opted for additional reproductive strategies than SOSR, presenting more plasticity to maximise seed yield. Overall, we conclude that OSR adopts a key strategy to ensure maximal seed yield and propose an ideal ideotype highlighting crucial phenotypic traits that could be potential targets for breeding.
[Changes of magnetization transfer ratio according to rat brain development]. (1996)

We assessed the age-related changes in magnetization transfer ratio (MTR) value and the ratio of water content in rat brain (frontal lobe and pons) during normal development. All studies were done on 42 normal Wistar rats. MTR was calculated by using the equation (Moff-Mon)/Moff, where Moff and Mon were the measured signal intensities on the conventional and MT-prepared SPGR images, respectively. The ratios of water content were measured by comparing the wet weight with the dry weight of the frontal lobe and the pons, which were extracted from a rat brain soon after MTR measurements. The ratio of water content was calculated by using the equation 100 x (wet weight-dry weight)/wet weight (%). The ratio of water content decreased markedly during the first 30 days, but the decrease was very slight there after both in the frontal lobe and the pons. The change in MTR was similar to that of the ratio of water content, though the direction of change was opposite. Statistically significant inverse relationships existed between MTR and the ratio of water content both in the frontal lobe and the pons. MTR could be a new parameter with which to assess brain development.
一种富集高温栅藻 Desmodesmus sp. F51的新型生物絮凝剂 (2019)

背景海科贝特氏菌(Cobetia marina)可产生大量具有絮凝活性的胞外产物，可视为一种新型的生物絮凝剂。高温栅藻(Desmodesmus sp. F51)是一种具有较高叶黄素含量的微藻，被认为是一种新兴的叶黄素来源，但利用该生物絮凝剂高效富集高温栅藻的相关研究迄今尚未见报道。 目的以高温栅藻为对象，研究该新型生物絮凝剂的絮凝效率，并对絮凝机理进行初步探讨。 方法探索在不同生长阶段微藻培养液添加生物絮凝剂、添加量、絮凝时间、pH对絮凝效率的影响，分析生物絮凝剂的功能基团，并测定在不同pH条件下添加生物絮凝剂前后高温栅藻的Zeta电位变化，以及在显微镜下分析藻细胞在添加生物絮凝剂前后的形态。 结果在高温栅藻生长至稳定期(pH 8.0)添加2 mL生物絮凝剂，絮凝15 min絮凝效果最佳，达82.1%。傅里叶红外光谱(fourier transform infrared spectroscopy, FTIR)显示了多糖及酰胺结构的特征吸收峰，由此推测生物絮凝剂主要是多糖的混合物，含有少量蛋白质。根据Bradford法测定絮凝剂中蛋白含量约为0.4% (质量比)，通过苯酚-硫酸法测定总糖质量分数约为34.5% (质量比)，与FTIR分析结果基本相符。生物絮凝剂在pH 4.0-11.0保持60%以上的絮凝效率，说明无论是酸性或是碱性条件下絮凝效率都较高，结合Zeta电位的分析表明，推测生物絮凝剂对高温栅藻的絮凝机理中占主导地位的可能是吸附架桥作用。 结论该研究对微藻生物絮凝具有重要的理论和实践意义。
La nueva forma de generación de energía (2018)

Segun Apple, sus amplios espacios verdes, su centro de bienestar y sus mas de 74.000 m2 de paneles solares conforman la mejor oficina del mundo. En este numero, Jonathan Wilkins, director de marketing del proveedor de piezas industriales EU Automation, explica como las grandes empresas se pueden beneficiar de la energia renovable.