gebhart/patrepeval huggingface dataset:
An Admission Control Algorithm for WCDMA Considering Mobile Speed and Service Characteristics (2005)

This paper deals with the problem of the downlink admission control for UTRA-FBD systems. In W-CDMA systems, elements such as traffic variability or user mobility cause that the resource requirements for each user in order to guarantee its QoS (quality of service) vary along time, making very difficult to estimate whether there will be or not available resources to satisfy the user demands. Admission control and other RRM (radio resource management) strategies play an important role in order to achieve an efficient use of the radio interface. In this context, information of certain user characteristics (such as user location or user mobility) would be prime important to obtain a more accurate estimation of the required resources for each user during its connection lifetime. This paper proposes an admission control algorithm which takes into account user mobility and service characteristics in order to obtain better decisions of admission or rejection of connection requests. The obtained results show the improvement of this new admission control proposal in heterogeneous scenarios when low-speed indoor users and medium/high-speed outdoor users have to coexist.
The death of John Gilbert (1996)

There was a greater improvement in masticatory efficiency and participants' OHRQoL when fitted with an anatomic tooth form mandibular overdenture retained by an immediate loading single implant than with a semianatomic or nonanatomic tooth form.
Targeted p16Ink4a epimutation causes tumorigenesis and reduces survival in mice (2014)

Cancer has long been viewed as a genetic disease; however, epigenetic silencing as the result of aberrant promoter DNA methylation is frequently associated with cancer development, suggesting an epigenetic component to the disease. Nonetheless, it has remained unclear whether an epimutation (an aberrant change in epigenetic regulation) can induce tumorigenesis. Here, we exploited a functionally validated cis-acting regulatory element and devised a strategy to induce developmentally regulated genomic targeting of DNA methylation. We used this system to target DNA methylation within the p16(Ink4a) promoter in mice in vivo. Engineered p16(Ink4a) promoter hypermethylation led to transcriptional suppression in somatic tissues during aging and increased the incidence of spontaneous cancers in these mice. Further, mice carrying a germline p16(Ink4a) mutation in one allele and a somatic epimutation in the other had accelerated tumor onset and substantially shortened tumor-free survival. Taken together, these results provide direct functional evidence that p16(Ink4a) epimutation drives tumor formation and malignant progression and validate a targeted methylation approach to epigenetic engineering.
P3‐264: PERIPHERAL AND CENTRAL INFLAMMATION DIFFER BY RACE AND ASSOCIATE WITH COGNITIVE PERFORMANCE IN A POPULATION AT RISK FOR ALZHEIMER'S DISEASE (2019)

Over 5 million people are estimated to have Alzheimer's disease (AD) in the United States; this number is expected to triple by 2050. Epidemiological studies indicate that modifiable risk factors characterized by elevated peripheral inflammation such as hypertension and metabolic syndrome are linked to development of neurodegenerative disease, including AD, and controlling blood pressure (BP) protects against AD. Importantly, African Americans (AA) are disproportionately affected by both vascular risk factors and AD than whites. Using multiplexed immunoassays, deep-immunophenotyping by flow cytometry, and cognitive tests, here we tested the hypothesis that cognition negatively correlates with inflammation in a cohort of middle- aged (45-65 yrs), cognitively normal individuals at high risk for AD based on parental history and an overrepresentation of the ApoE4 allele. AA individuals had higher plasma and CSF CRP and plasma IL-6, and lower plasma IL-8 and CSF NGAL than whites. We regressed cognitive scores on plasma and CSF inflammatory factors after adjusting for appropriate confounders (age, sex, education, and ApoE4). MOCA score, which assesses global cognition, negatively associated with plasma NGAL and IL-10, and CSF IL-10, Buschke score, which assesses verbal memory, negatively associated with plasma IL-8, TNF and NGAL, and positively associated with CSF IFNγ. When controlling only for APOE4, verbal memory was positively associated with plasma NGAL and CSF IL-6 and negatively associated with plasma TNF and CSF IL-10 and IL-8. Executive function, as measured by TrailsB score positively associated with CSF IL-8 and TNF protein; when controlling only for APOE4, TrailsB score positively associated with CSF IL-8. Language, as measured by MINT score was positively associated with plasma TNF. Experiments are ongoing to immunophenotype CSF and blood via flow cytometry. This investigation will aid in understanding the relationship and role of central and peripheral inflammation on cognition in individuals at high risk for AD.
HLA and rheumatoid arthritis: susceptibility or severity? (1986)

An analysis of data collected on 440 British Caucasoid rheumatoid arthritis patients has confirmed positive association with HLA-DR4, Dw4, DRw53, and A2 and negative associations with HLA-DR2, 3, and 7. HLA-DR4 is more associated with RA 'severity' than with RA 'susceptibility', when measured by the parameters of ARA classification, seropositivity, severity of erosions and extra-articular manifestations. The association between HLA-A2, Cw3, Bw62, DR4, DRw53, and Dw4 and extra-articular disease has been confirmed in this study. The analysis of HLA and RA severity with respect to sex showed high frequencies of DR4, Dw4, and DRw53 in females, which increased in those with severe erosions, seropositivity or extra-articular disease. In males with RA, the disease appears to be associated not only with DR4, Dw4 and DRw53, but also with A2, Cw3 and Bw62. However, no significant differences in these antigen frequencies were found between male patients with severe RA and those without. Despite a significant decrease in the frequencies of DR3, B8 and A1 in most RA patient subsets, RA patients with Sjogren's syndrome showed a marked increase of A1 and B8 and patients with auto-antibodies had a significant increase in HLA-DR3 frequency when compared with patients without these features.
Ingredients in skin lightening (2009)

Irregular pigmentation of the face is one of the most common signs of photoaging.Skin tanning in people of all skin colors is due to UVA radiation.Most sunscreens focus on preventing sunburn,which is due to UVB radiation.They do not prevent tanning,since UVA radiation still strikes the skin.It is pointed out that the best method of skin lightening is avoiding sun damage.A successful treatment must remove existing pigment from the skin,shut down the manufacturing of additional melanin pigment and prevent the transfer of existing melanin pigment to the melanosomes.Several main ingredients in skin lightening products and the effect were introduced.
Efficient nonreciprocal mode transitions in spatiotemporally modulated acoustic metamaterials (2021)

In linear, lossless, time-invariant, and nonbiased acoustic systems, mode transitions are time reversible, consistent with Lorentz reciprocity and implying a strict symmetry in space-time for sound manipulation. Here, we overcome this fundamental limitation by implementing spatiotemporally modulated acoustic metamaterials that support nonreciprocal sound steering. Our mechanism relies on the coupling between an ultrathin membrane and external biasing electromagnetic fields, realizing programmable dynamic control of the acoustic impedance over a motionless and noiseless platform. The fast and flexible impedance modulation of our metamaterial imparts an effective unidirectional momentum in space-time to realize nonreciprocal transitions in <i>k</i>-ω space between different diffraction modes. On the basis of these principles, we demonstrate efficient nonreciprocal sound steering, showcasing unidirectional evanescent wave conversion and nonreciprocal upconversion focusing. More generally, our metamaterial platform offers opportunities for generation of nonreciprocal Bloch waves and extension to other domains, such as non-Hermitian topological and parity-time symmetric acoustics.
The effect of maternal HMB supplementation on bone mechanical and geometrical properties, as well as histomorphometry and immunolocalization of VEGF, TIMP2, MMP13, BMP2 in the bone and cartilage tissue of the humerus of their newborn piglets (2021)

The presented experiment focuses on assessing the impact of HMB (hydroxy-β-methobutyrate) supplementation of mothers during pregnancy on the development of the skeletal system of their offspring. For this purpose, an experiment was carried out on 12 clinically healthy sows of the Great White Poland breed, which were divided randomly into two groups the control and the HMB group. All animals were kept under standard conditions and received the same feed for pregnant females. In contrast, females from the HMB group between 70 and 90 days were supplemented with 3-hydroxy-3-methylbutyle in the amount of 0.2g/kg b.w/day. Immediately after birth, the piglets were also divided into groups based on: sex, and presence or lack HMB supplementation, and subsequently were euthanized and humerus bones from all piglets were collected. Mother's HMB supplementation during pregnancy affected the multiple index of their offspring. The higher humerus mass and length was observed with the greater effect in males. Maternal supplementation also influenced on the geometrical and mechanical properties of the humerus as in the case of mass, this effect was higher in males. Also, the collagen structure of the compacted and trabecular bone changed under the HMB addition. Maternal supplementation also affected the expression of selected proteins in growth cartilage and trabecular bone. The obtained results show that the administration to the mother during pregnancy by the HMB significantly affects the development of the humerus in many ways. The obtained results also confirm the utility of such experiments in understanding of the importance of the pregnancy diet as an develop and adaptable factor of offspring organisms and are the base for further research in that area as well as in the protein markers expression area.
The nonlinear response of Boolean models: elasticity and conductivity (2018)

Online at http://www.cmm.mines-paristech.fr/~willot/publi2018c.pdf
Absolute phase estimation: adaptive local denoising and global unwrapping (2008)

The paper attacks absolute phase estimation with a two-step approach: the first step applies an adaptive local denoising scheme to the modulo-2 pi noisy phase; the second step applies a robust phase unwrapping algorithm to the denoised modulo-2 pi phase obtained in the first step. The adaptive local modulo-2 pi phase denoising is a new algorithm based on local polynomial approximations. The zero-order and the first-order approximations of the phase are calculated in sliding windows of varying size. The zero-order approximation is used for pointwise adaptive window size selection, whereas the first-order approximation is used to filter the phase in the obtained windows. For phase unwrapping, we apply the recently introduced robust (in the sense of discontinuity preserving) PUMA unwrapping algorithm [IEEE Trans. Image Process.16, 698 (2007)] to the denoised wrapped phase. Simulations give evidence that the proposed algorithm yields state-of-the-art performance, enabling strong noise attenuation while preserving image details.
FK506 (tacrolimus), a novel immunosuppressant in organ transplantation: clinical, biomedical, and analytical aspects (1993)

The macrolide immunosuppressant FK506 (tacrolimus) is a powerful and selective anti-T-lymphocyte agent that was discovered in 1984. This agent, isolated from the fungus Streptomyces tsukubaensis, has a mechanism of action similar to that of cyclosporine. Experimental data were first published in 1987, and clinical trials were started 2 years later in Pittsburgh. The drug has a potent hepatotrophic effect, which could explain its success in liver transplantation. Particularly encouraging results were obtained in liver allograft recipients, suggesting a lower risk/benefit ratio than with other immunosuppressants. However, recent data show that the drug is not devoid of toxicity (mainly nephrotoxicity), which should the percent the need for careful blood monitoring. Several methods of analysis have been described, some satisfactory, others inadequate for routine monitoring. There is still a lack of specific methods to determine routinely the parent drug concentrations in biological fluids for clinical pharmacokinetics purposes. Despite greater experience in therapeutic drug monitoring, the correlation between FK506 concentrations and efficacy or toxicity is still unclear. More investigations are required to better understand and determine the appropriate use of FK506 in organ transplantation and treating autoimmune diseases.
Corneal Collagen Cross-linking in Keratectasia (2009)

In recent years, increased attention has been paid to the biomechanical properties of the cornea. Corneal biomechanics are altered not only in inherited and acquired corneal conditions, such as ectatic disorders or melting processes, but also by refractive surgical procedures. Therefore, a therapeutic approach to increase the biomechanical and biochemical resistance of the cornea would address important issues in a variety of corneal disorders. Corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A (UVA) is an innovative clinical technique that fulfils these criteria. To assist researchers and clinicians interested in the field, this article provides a comprehensive overview of the current state of CXL, its basic principles, the technique and clinical indications, but also safety issues and potential complications.
Indirect maternal deaths: UK and global perspectives (2017)

Indirect maternal deaths outnumber direct deaths due to obstetric causes in many high-income countries, and there has been a significant increase in the proportion of maternal deaths due to indirect medical causes in low- to middle-income countries. This review presents a detailed analysis of indirect maternal deaths in the UK and a perspective on the causes and trends in indirect maternal deaths and issues related to care in low- to middle-income countries. There has been no significant decrease in the rate of indirect maternal deaths in the UK since 2003. In 2011-2013, 68% of all maternal deaths were due to indirect causes, and cardiac disease was the single largest cause. The major issues identified in care of women who died from an indirect cause was a lack of clarity about which medical professional should take responsibility for care and overall management. Under-reporting and misclassification result in underestimation of the rate of indirect maternal deaths in low- to middle-income countries. Causes of indirect death include a range of communicable diseases, non-communicable diseases and nutritional disorders. There has been evidence of a shift in incidence from direct to indirect maternal deaths in many low- to middle-income countries due to an increase in non-communicable diseases among women in the reproductive age. The gaps in care identified include poor access to health services, lack of healthcare providers, delay in diagnosis or misdiagnosis and inadequate follow-up during the postnatal period. Irrespective of the significant gains made in reducing maternal mortality in many countries worldwide, there is evidence of a steady increase in the rate of indirect deaths due to pre-existing medical conditions. This heightens the need for research to generate evidence about the risk factors, management and outcomes of specific medical comorbidities during pregnancy in order to provide appropriate evidence-based multidisciplinary care across the entire pathway: pre-pregnancy, during pregnancy and delivery, and postpartum.
Reactions of [(organosilyl)amino]boranes with selected hydrides (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of [(organosilyl)amino]boranes with selected hydridesW. Rodger Nutt and Richard L. WellsCite this: Inorg. Chem. 1982, 21, 6, 2469–2473Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/ic00136a067https://doi.org/10.1021/ic00136a067research-articleACS PublicationsRequest reuse permissionsArticle Views189Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Midplane Faraday rotation: A densitometer for large tokamaks (1992)

The density in a large tokamak such as International Thermonuclear Experimental Reactor (ITER), or any of the proposed future US machines, can be determined by measuring the Faraday rotation of a 10.6 μm laser directed tangent to the toroidal field. If there is a horizontal array of such beams, then ne(R) can be readily obtained with a simple Abel inversion about the center line of the tokamak. For a large machine, operated at a full field of 30 T m and a density of 2×1020/m3, the rotation angle would be quite large−about 60° for two passes. A layout in which a single laser beam is fanned out in the horizontal midplane of the tokamak, with a set of retroreflectors on the far side of the vacuum vessel, would provide good spatial resolution, depending only upon the number of reflectors. With this proposed layout, only one window would be needed. Because the rotation angle is never more than 1 ‘‘fringe,’’ the data is always good, and it is also a continuous measurement in time. Faraday rotation is dependent only upon the plasma itself, and thus is not sensitive to vibration of the optical components. Simulations of the expected results show that ITER, or any large tokamak, existing or proposed, would be well served even at low densities by a midplane Faraday rotation densitometer of ∼64 channels.
A Clustering-based Feature Selection for Automatic Labeling in Human Activity Recognition (2022)

Due to the popularity of mobile devices and wearable sensors, improving the accuracy of human activity recognition has become a research topic. However, to train an actual model based on machine learning in HAR, it is necessary to collect sensor information of a large number of samples and mark each sample as belonging to a specific activity. Therefore, designing an automatic labeling method is important in HAR research. In this study, we applied the feature selection based on fuzzy C-means particle swarm optimization (FS-FCPSO) to improve the accuracy of the automatic labeling results. Through the FS-FCPSO method, six human activities are automatically marked according to the selected important features, including walking, sitting, standing, upstairs, downstairs, and lying down. The results of these six activities are automatically marked by the FS-FCPSO method. Our results show that the FS-FCPSO method is more suitable for automatic marking in HAR than K-means and fuzzy C-means algorithms.
Near-Field Distribution of Optical Transmission of Periodic Subwavelength Holes in a Metal Film (2001)

Optical transmission of a two-dimensional array of subwavelength holes in a metal film has been numerically studied using a differential method. Transmission spectra have been calculated showing a significant increase of the transmission in certain spectral ranges corresponding to the excitation of the surface polariton Bloch waves on a metal surface with a periodic hole structure. Under the enhanced transmission conditions, the near-field distribution of the transmitted light reveals an intensity enhancement greater than 2 orders of magnitude in localized ( approximately 40 nm) spots resulting from the interference of the surface polaritons Bragg scattered by the holes in an array.
The effect of endotoxin on murine stem cells (1973)

Abstract Previous studies showed that after 5 μg of Salmonella typhosa endotoxin there was an increase in colony stimulating factor temporally related to a fall in murine marrow in vitro colony forming cells (CFC). This was followed by differentiation along the marrow granulocytic pathway. The present studies showed that after 5 μg of endotoxin the peripheral blood CFC fell by approximately 50% at one hour, rose to a level ten fold that of control at six hours and then returned to control values by 48 hours. There was a progressive increase in the number of splenic CFC to ten fold that of control from 24 to 72 hours after endotoxin. These data imply a migration of CFC from the marrow to the spleen along with an in‐situ increase in splenic CFC. Thus, either migration or differentiation may explain the fall in marrow CFC after endotoxin. Spleen colony forming units (CFU) in the marrow were measured by a transplantation technique and the transplantation fraction (f Fx) determined. A decrease in marrow CFU at 24 hours after endotoxin was secondary to a change in the f Fx. from 11.1% to 7.6%. There was however, an increased percentage of CFU in DNA synthesis in the interval of 6–48 hours after endotoxin, as judged by the hydroxyurea technique. As the marrow CFC fell within 20 minutes of endotoxin administration, the data suggest the CFC may be affected initially and that changes in the generative cycle of the CFU may be of a secondary nature.
Method of removing iodine and compounds thereof from gaseous effluents. [Absorption of iodine and its compounds from reactor effluents] (1976)

Anion exchange resins including an acrylic backbone formed by the suspension polymerization of a mixture of an acrylic and a crosslinking monomer are useful in the removal of iodine and iodine compounds from gaseous effluents. Removal of radioactive iodine contaminants, particularly alkyl iodine compounds or hydrogen iodine, under extreme conditions, namely temperatures up to 180/sup 0/C and humidities up to 100 percent, from effluents resulting from a major nuclear accident could probably be adsorbed by these resins described herein. (BLM)