gebhart/patrepeval huggingface dataset:
DSF: A Distributed SDN Control Plane Framework for the East/West Interface (2021)

The ever-increasing number of network-capable devices places a massive burden on modern networks. Communication infrastructure should provide quality-of-service essentials in terms of high-bandwidth capacity, scalability, resiliency, and security. Programmable networks are viewed as the prevailing method of encountering the challenges introduced by the accelerated expansion. The ability of software-defined networking (SDN) to separate the control plane from the data plane and enable the programmability of the network creates new ways to architect the network. The centralization of control logic introduces complexities in large-scale, distributed networks such as performance bottlenecks and reliability. Distributed SDN controllers have been proposed to overcome the performance concerns. The lack of a communication standard among distributed controllers, referred to as the East/West interface, presents a challenge in the adoption of SDN in large-scale, distributed networks. In this paper, we propose Distributed SDN control plane Framework (DSF) - a framework for the East/West interface for heterogeneous, distributed SDN controllers to synchronize topologies using a standardized data-centric real-time publish/subscribe paradigm known as the Data Distribution Service (DDS). Distributed control plane architectures are proposed using DSF: flat, hierarchical, and T-model. The DSF interface is implemented on multiple SDN control plane platforms to evaluate performance: Floodlight and Open Network Operating System (ONOS) controllers. Test cases with different configurations are designed for performance evaluation of the proposed interface in homogeneous and heterogeneous SDN control planes. In addition, a performance comparison is presented of DSF-based ONOS controllers versus Atomix-based ONOS cluster solutions.
Measuring the PEM fuel cell performance in a versatile test station (2009)

In this paper the performance characterization of a PEM fuel cell has been carried out using an experimental analysis. The experimental activity has been conducted in a test station, properly designed and able to test PEM fuel cell stacks in the range 500-2000 W. The laboratory test facility is equipped by a National Instruments compact DAQ real-time data acquisition and control system running LabView software. The bench commands two mass-flow controllers, regulating both fuel flow and air flow which are commanded via two RS232 ports. The temperature of the FC is regulated via a fan operated by a brushless motor drive. An electronic load is connected to the FCM. The main operating parameters, such as air stoichiometric ratio and fuel composition, have been varied and measured and their influence on the PEM fuel cell behavior has been investigated under both steady-state and transient conditions.
Safety and efficacy of tazemetostat, an enhancer of zeste-homolog 2 inhibitor, in patients with relapsed or refractory malignant mesothelioma. (2020)

9058 Background: Breast cancer gene 1 (BRCA1)-associated protein 1 (BAP1), a nuclear deubiquitinase, is commonly inactivated in malignant mesothelioma. Preclinical data showed that BAP1 inactivation sensitizes mesothelial cells to inhibition of enhancer of zeste-homolog 2 (EZH2), a methyltransferase implicated as an oncogenic driver in this tumor. This study evaluated the safety and efficacy of tazemetostat (TAZ), a potent and selective EZH2 inhibitor, in relapsed/refractory (R/R) malignant mesothelioma with BAP1-inactivation. Methods: EZH-203 (NCT02860286) was a 2-part, open-label, phase 2 study that assessed the pharmacokinetics (PK), safety, and efficacy of TAZ in pts with R/R malignant mesothelioma. In part 1, pts received TAZ 800 mg QD on day 1 (D1) and 800 mg BID, beginning day 2 of cycle 1 (C1). In part 2, pts received 800 mg of TAZ BID on D1 of C1. A two-stage Green-Dahlberg design was used for part 2. Primary endpoints were PK profiling of TAZ in all pts (part 1), and disease control rate (DCR) at week 12 in pts with BAP1-deficient R/R malignant mesothelioma (part 2). Secondary endpoints included safety, overall response rate (ORR), progression-free survival, overall survival, and duration of response (DOR). Results: The study enrolled 74 pts with R/R malignant mesothelioma, 70 pts (95%) were centrally confirmed to be BAP1-deficient. Median prior lines of therapy were 2 (range, 1-9). Observed clinical data in the presence of CYP3A4 inhibitors and inducers suggest a low DDI potential of TAZ. The 12 week DCR was 47% (n = 35). The ORR per RECIST version 1.1 was 3% [complete response: 0%; partial response (PR): 3% (n = 2)]. Of the 2 patients with PR, 1 had a DOR of 21 weeks and the other is ongoing (15.3 weeks at data cut off). 47 pts (64%) and 21 pts (28%) had stable disease (SD) and progressive disease, respectively. Overall, 91% pts discontinued, either due to disease progression (n = 65), death (n = 5), or treatment discontinuation (n = 1). Grade ≥3 treatment-emergent adverse events (TEAEs) occurred in ≤5% of patients, most commonly anemia (5%) and dyspnea (4%). No pts discontinued due to TEAEs. There were no treatment related deaths. Conclusions: Based on disease control rate and stable disease, TAZ showed antitumor activity in pts with BAP1-deficient R/R malignant mesothelioma. TAZ monotherapy was generally well-tolerated. The current data support further clinical evaluation of TAZ in these pts. Furthermore, this trial presents an optimal paradigm for drug development in molecularly-enriched cohorts in mesothelioma. Clinical trial information: NCT02860286.
Functioning Paraganglioma and Gastrointestinal Stromal Tumor of the Jejunum in Three Women (2006)

Functioning paraganglioma and gastrointestinal stromal tumor (GIST) are uncommon tumors that occur mostly in a sporadic and isolated form, occasionally as components of multiple neoplasia syndromes, either separately or together. Separately, they occur in several inherited syndromes including multiple endocrine neoplasia 2, and the GIST, lentigines, and mast cell tumor syndrome. Together, they are variably prominent components of three syndromes: the familial paraganglioma and gastric GIST syndrome, neurofibromatosis type 1, and the Carney triad. The two former conditions are inherited as autosomal dominant traits; the latter does not appear to be inherited and affects young women predominantly. This article reports the nonfamilial occurrence of functioning paraganglioma and GIST of the jejunum in 3 women, 1 young (22 years) at initial presentation. The occurrences were unexpected because of the infrequency of the tumors. The neoplasms, respectively, did not show germline SDHA, SDHB, SDHC, and SDHD, and KIT mutations associated with familial paraganglioma and familial GIST. The paraganglioma-jejunal GIST combination may be the harbinger of a rare genetic syndrome, a variant of the Carney triad or the paraganglioma-gastric stromal sarcoma syndrome, or be coincidental.
Indication of Complete Spin Filtering in Atomic-Scale Nickel Oxide (2015)

Generating highly spin-polarized currents at the nanoscale is essential for spin current manipulations and spintronic applications. We find indications for up to 100% spin-polarized currents across nickel oxide atomic junctions formed between two nickel electrodes. The degree of spin polarization is probed by analyzing the shot noise resulting from the discrete statistics of spin-polarized electron transport. We show that spin filtering can be significantly enhanced by local chemical modifications at the single-atom level. This approach paves the way for effective manipulations of spin transport at the fundamental limit of miniaturization.
Structural studies of binuclear suiphido-bridged complexes of tungsten. Preparation and X-ray crystal structures of [S2W(µ-S)2W(NNMe2)2(PPh3)] and [{W(SBut)2(PMe2Ph)}2(µ-S)2]·CH2Cl2 (1983)

The reaction of [NBun4]2[WS4] with [WCl(NNMe2)2(PPh3)2]Cl yields the asymmetric binuclear complex [S2W(µ-S)2W(NNMe2)2(PPh3)](1). Complex (1) crystallizes in space group Cc, with a= 15.389(2), b= 10.292(4), c= 18.406(2)Å, β= 90.43(1)°, and Z= 4; final R= 0.061 based on 4 091 reflections collected, 2 116 used. One tungsten is trigonally pyramidally co-ordinated with two NNMe2 groups in the equatorial plane and one axial and one equatorial bridging sulphide with a W–W separation of 3.024(1)Å. The reaction of cis-[W(N2)2(PMe2Ph)4] with ButSH gives the symmetric binuclear complex [{W(SBut)2(PMe2Ph)}2(µ-S)2](2). Complex (2) crystallises in space group P, with a= 9.654(4), b= 10.331(4), c= 13.288(5)Å, α= 78.09(1), β= 69.36(1), γ= 82.49(1)°, and Z= 1; final R= 0.071 based on 4 732 reflections collected, 2 310 used. The centre of symmetry imposes planarity on the W2S2 system with a W–W distance of 2.736(2)Å. Each tungsten has distorted trigonal-bipyramidal geometry with bridging sulphide and phosphorus in the apical sites.
Noninvasive detection of plant nutrient stress using fiber optic spectrophotometry (2001)

In a previous paper, we described the use of fiber optic spectrophotometry as a non-destructive and sensitive method to detect early symptoms of plant nutrient deficiency. We report further developments of our work on Brassica chinensis var parachinensis (Bailey) showing reproducibility of our data collected at a different seasonal period. Plants at the mid-log growth phase were subjected to nutrient stress by transferring them to nitrate- and calcium- deficient nutrient solution in a standing aerated hydroponic system. After tracking changes in leaf reflectance by FOSpectr for nine days, the plants were returned to complete nutrient solution and their recovery was monitored for a further nine days. The responses of nutrient stressed plants were compared with those grown under complete nutrient solution over the 18-day trial period. We also compared the sensitivity of FOSpectr detection against plant growth measurements vis-a-vis average leaf number and leaf width and show that the former method gave an indication of nutrient stress much earlier than the latter. In addition, this work indicated that while normal and nutrient-stressed plants could not be distinguished within the first 7 days by tracking plant growth indicators, stressed plants did show a clear decline in average leaf number and leaf width in later stages of growth even after the plants were returned to complete nutrient solution. The results further reinforce the need for early detection of nutrient stress, as late remedial action could not reverse the loss in plant growth in later stages of plant development.
Cellulose sulfate increases blood concentration of kinins in rats. (1989)

Intravenous injection of cellulose sulfate (CS) in rats induced a dose-dependent decrease of blood pressure accompanied by a concomitant increase of circulating levels of immunoreactive bradykinin (BK) from a level of 52 pg/mL of blood in control animals to 400 pg/mL in the group injected with 3.0 mg/kg of CS. An increase of desArg9BK was also observed while the blood concentration of BK(1-7) remained constant. Kinins contents in acidic extracts of lungs increased slightly while renal kinins from the same animals showed a slight decrease. The results suggest that plasma kallikrein-kinin system mediates CS-induced hypotension and that glandular kallikreins do not participate to the hypotensive action of CS.
Implantation of a Recurrent Laryngeal Nerve Stimulator for the Treatment of Spastic Dysphonia (1989)

Spastic dysphonia, a rare speech disorder, is characterized by strained phonation with excessively adducted vocal cords. Recurrent laryngeal nerve section, botulinum toxin injection into the vocalis-thyroarytenoid muscle complex, and other techniques have been used to treat this disorder. We have used percutaneous electrical stimulation of the recurrent laryngeal nerve with good results. Previous dog studies demonstrated the relative safety of an implantable recurrent laryngeal nerve stimulator. In this study, we directly stimulated the recurrent laryngeal nerve and vagus nerve in a dog without change in cardiorespiratory status. A Medtronic peripheral nerve stimulator was implanted in a patient with abductor spastic dysphonia. The cuff electrode was positioned around the recurrent laryngeal nerve and stimulation resulted in improvement in her voice. Extensive cardiopulmonary monitoring did not reveal any adverse response to stimulation and there was no discomfort to the patient. On the basis of the good results of this preliminary study, further study with long-term follow-up is under way.
TROPiCS–03: A phase II open-label study of sacituzumab govitecan (SG) in patients with metastatic solid tumors. (2020)

TPS3648 Background: Trophoblast cell surface antigen (Trop-2) is highly expressed in many epithelial cancers (non–small-cell lung cancer [NSCLC], endometrial cancer, urothelial carcinoma [UC], and triple-negative breast cancer [TNBC]) and has been linked to aggressive disease and poor prognosis. SG is a Trop-2–directed antibody drug conjugate containing SN-38 (active metabolite of irinotecan) with a 7.5:1 drug-to-antibody ratio and unique hydrolyzable linker that allows for extracellular bystander effect. The phase 1/2 IMMU-132-01 basket study reported clinical activity with SG in patients with multiple tumor types not selected for Trop-2 expression including NSCLC (objective response rate [ORR]: 17%), TNBC (ORR: 33%), and UC (ORR: 31%).1-3 Results from the overall safety population (N=420) from this study found that SG was tolerable, with a predictable and manageable safety profile, and low discontinuation rates due to AEs. Methods: To test a biomarker-enrichment strategy with Trop-2, the TROPiCS-03 (TROP-2 Investigations in Cancer with SG) study was initiated. TROPiCS-03 (NCT03964727) is a multi-cohort, open-label, phase 2 study in patients with metastatic solid tumors - presently NSCLC (adenocarcinoma and squamous cell carcinoma), head and neck squamous cell carcinoma, and endometrial cancer - selected based on elevated Trop-2 expression by a validated IHC assay. Patients receive SG (10 mg/kg IV, days 1 and 8 every 21 days) and continue treatment until lack of clinical benefit or unacceptable toxicity. The primary endpoint is objective response rate (local assessment) and additional endpoints include clinical benefit rate, duration of response, progression-free survival, and safety. Females or males ≥18 years old who are histologically documented to have locally advanced or metastatic (M1, stage 4) solid tumors of the above types are eligible. Patients must have ECOG 0 or 1 and adequate clinical laboratory results to be enrolled. All subjects will have progressed after prior platinum-based chemotherapy and programmed death-ligand 1 (PD-L1) or programmed cell death protein 1 (PD-1) directed therapy. Patients who have previously received topoisomerase I inhibitors and those with known active CNS metastases are excluded. Approximately 160 patients will be enrolled in the trial overall; enrollment in the NSCLC cohort is currently in progress. References: Heist RS et al. J Clin Oncol. 2017;35:2790-7, Bardia A et al., NEJM. 2019;380:741-51.,Tagawa ST et al., Oral presentation; ASCO-GU 2019, San Francisco, CA. Clinical trial information: NCT03964727 .
Design, Performance, and Testing of a Brushless Axial Flux Resolver Without Rotor Windings (2016)

Resolvers are electromagnetic position sensors that are widely used in industrial applications. In this paper, a novel axial flux resolver with a simple solid rotor is introduced for the first time. The stator of the proposed resolver has a disk type structure with two-phase distributed windings as signal windings and a concentric winding as an excitation winding. The rotor is a disc with a simple structure. Its width is 20° without any winding, and thus, the proposed resolver has the advantages of variable reluctance resolvers for having no winding on rotor and also its manufacturing process is much simpler than that of variable reluctance resolvers. The performance analysis of the proposed structure is simulated and optimized using a 3D time stepping finite element method. Then, a prototype is constructed based on the optimized dimensions and tested. Good agreement between the simulation and the experimental results validates the success of the proposed resolver.
Nucleotide sequences of the trailer, nucleocapsid protein gene and intergenic regions of Newcastle disease virus strain Beaudette C and completion of the entire genome sequence. (1998)

The nucleotide sequences of the nucleocapsid protein (NP) gene, the intergenic regions in the nucleocapsid protein (NP)-phosphoprotein (P), P-matrix protein (M) and M-fusion glycoprotein gene junctions and the trailer region of a virulent Newcastle disease virus (NDV) strain Beaudette C were determined. The NP gene is 1747 nt long and encodes a protein of 489 amino acids. Each of the intergenic sequences determined is 1 nt long and, including the previously published intergenic sequences, the gene junction sequences varied in length from 1-47 nt and lacked any sequence identity. The 5' trailer region is 113 nt in length. Comparison of the sequences of the terminal leader and trailer regions of Beaudette C strain with those of nonvirulent strain B1 showed a high level of conservation, indicating the likelihood of these elements not being a factor in virulence. Together with previously published data, this report completes the sequence of the 15,186 nt genomic RNA of NDV strain Beaudette C.
Short‐term Prediction—An Overview (2003)

Abstract This article gives an overview of the different methods used today for predicting the power output from wind farms on the 1–2 day time horizon. It describes the general set‐up of such prediction systems and also gives examples of their performance. Copyright © 2003 John Wiley &amp; Sons, Ltd.
Orlistat-loaded solid SNEDDS for the enhanced solubility, dissolution, and in vivo performance (2018)

In conclusion, the suggested novel SSP formulation would be an effective and promising candidate for the treatment of obesity.
Increase of CC chemokine receptor 4‐positive cells in the peripheral CD4+ cells in dogs with atopic dermatitis or experimentally sensitized to Japanese cedar pollen (2004)

The proportion of CCR4+ cells in peripheral blood CD4+ cells was measured in dogs with allergic conditions. The present findings indicate that CCR4+ cells may be involved in the pathogenesis of allergy in dogs as in humans.
In-Process Temperature Mapping System for Industrial Freeze Dryers (2010)

This paper describes a low-invasive temperature mapping system specially designed for vacuum and nonaccessible environments, such as industrial freeze dryers. Thermal resistances tend to become quite hight in vacuum since convection is absent and even very small gaps have extremely conductive resistances. Temperature monitoring in the vacuum therefore requires sensors that do not inject power to minimize the self-heating and a special attention to the effect due to the involved thermal resistances. The proposed solution employs small autonomous measuring nodes that use a wireless connection to transmit the results and that are characterized to correct the thermal constant effect during temperature changes. The system has been designed for the monitoring of large freeze dryers, but its characteristics make it useful in many other vacuum conditions. The system is capable of monitoring the temperature of hundreds of points with an uncertainty of the order of a degree and with a cost per point of a few euros.
Designing agility and resilience into embedded systems (2017)

Cyber-Physical Systems (CPS) such as Unmanned Aerial Systems (UAS) sense and actuate their environment in pursuit of a mission. The attack surface of these remotely located, sensing and communicating devices is both large, and exposed to adversarial actors, making mission assurance a challenging problem. While best-practice security policies should be followed, they are rarely enough to guarantee mission success as not all components in the system may be trusted and the properties of the environment (e.g., the RF environment) may be under the control of the attacker. CPS must thus be built with a high degree of resilience to mitigate threats that security cannot alleviate. In this paper, we describe the Agile and Resilient Embedded Systems (ARES) methodology and metric set. The ARES methodology pursues cyber security and resilience (CSR) as high level system properties to be developed in the context of the mission. An analytic process guides system developers in defining mission objectives, examining principal issues, applying CSR technologies, and understanding their interactions.
DNA-Templated Molecular Silver Fluorophores (2013)

Conductive and plasmon-supporting noble metals exhibit an especially wide range of size-dependent properties, with discrete electronic levels, strong optical absorption, and efficient radiative relaxation dominating optical behavior at the ~10-atom cluster scale. In this Perspective, we describe the formation and stabilization of silver clusters using DNA templates and highlight the distinct spectroscopic and photophysical properties of the resulting hybrid fluorophores. Strong visible to near-IR emission from DNA-encapsulated silver clusters ranging in size from 5-11 atoms has been produced and characterized. Importantly, this strong Ag cluster fluorescence can be directly modulated and selectively recovered by optically controlling the dark state residence, even when faced with an overwhelming background. The strength and sequence sensitivity of the oligonucleotide-Ag interaction suggests strategies for fine tuning and stabilizing cluster-based emitters in a host of sensing and biolabeling applications that would benefit from brighter, more photostable, and quantifiable emitters in high background environments.
Gold‐Catalyzed Intermolecular Addition of Carbonyl Compounds to 1,6‐Enynes: Reactivity, Scope, and Mechanistic Aspects (2009)

A full account of a recently discovered gold(I)-catalyzed reaction, a cycloaddition of carbonyl compounds to enynes yielding 2-oxabicyclo[3.1.0]hexanes with four stereogenic centers, is presented. The reaction proceeds with very high diastereoselectivity. The scope of the reaction has been investigated. In addition, experiments and DFT calculations concerning mechanistic aspects were carried out. The reaction course varies with the substitution pattern of the alkene moiety of the starting enyne. Branched olefins led to 2-oxabicyclo[3.1.0]hexanes; terminally substituted olefins proceeded with the incorporation of two carbonyl components to give hexahydrocyclopenta[d][1,3]dioxines.
Les facteurs biologiques de demain sont-ils valables aujourd'hui ? (2005)

Colloque avec actes et comité de lecture. Internationale.