gebhart/patrepeval huggingface dataset:
Physiological Function of Blood Vessels from Uncontrolled Donation after Circulatory Death in Pigs (2021)

Donation after circulatory death (DCD) has become increasingly important in kidney transplantation. Challenges, including early graft loss and delayed graft function, remain. Little is known regarding vascular properties. The aim was to examine effects of DCD on renal artery function in a novel pig extended DCD model, extending the time from circulatory arrest to retrieval of the organ to more than 4 hours, making it more feasible to recruit more organs from DCD. Renal and iliac arteries were obtained from animals immediately after euthanasia (fresh) and 4.5hr after DCD. Vessels were also analyzed after 10hr at 4°C in physiological salt solution (stored). Preparations were mounted for isometric force recording in vitro and examined at optimal stretch for active tension. Iliac arteries were more sensitive to noradrenaline compared to renal artery, possibly reflecting differences in sympathetic control of perfusion in renal and hind limb vascular beds. Active tension (depolarization, noradrenaline activation) was significantly lower in DCD renal arteries compared to fresh vessels. Stored renal arteries were also weaker, but to a lower extent, whereas iliac artery was only marginally weakened in uDCD and unaffected by storage. For both vessel types, DCD caused a significant attenuation of endothelial-mediated relaxation. Kidneys from uDCD donors performed poorly after transplantation, as expected, with a somewhat better result if the donor was given the standard protocol, including cooling after two hours. In conclusion, DCD introduces changes both in contractile function and endothelium-mediated relaxation of renal arteries. Effects were more pronounced than in iliac artery, suggesting that DCD could be one factor affecting the functional circulation of the donor kidney after transplantation. Further studies of uDCD subject to reconditioning before transplantation is underway to study the reversibility of changes to the endothelial function after our uDCD protocol.
Is Accurate Rate Response Programming Necessary? (1990)

Exercise capacity and general well-being are improved by appropriately programmed rate responsive pacemakers when compared to fixed rate units. Ten patients had activity sensing DDDR units implanted for combined AV block and sinus node incompetence. Ten patients had Sensolog activity sensing VVIR units implanted for complete heart block. The effects of over and under programming of rate response in both dual and single chamber activity sensor rate adaptive pacemakers has been assessed subjectively by visual analog scales and specific activity questionnaires and objectively by graded treadmill testing and the performance of standardized daily activities. Patients were randomly programmed to absent rate response (VVI in the Sensolog group), hyporesponsive (DDD in the dual chamber group), appropriate response (VVIR, DDDR according to Manufacturer's instructions) and over responsive (VVIR+, DDDR+) in a double-blind crossover design. Thirty percent of patients demanded early crossover from VVI, 30% from DDDR+ and 50% from VVIR+. Perception of Exercise Capability was similar to objective exercise treadmill times which were shorter in VVI than in VVIR or VVIR+ (P less than 0.05) or control subjects (P less than 0.001). There was no difference between any dual chamber mode or control subjects. General well-being was poorest in DDDR+ and VVIR+ modes despite objective improvement in exercise capacity. Symptoms were least in VVIR and DDDR and all but one patient chose appropriate programming as their overall preferred mode. Thus, even inaccurate rate response programming results in similar and improved exercise capacity compared to absent rate response but overprogramming is unacceptable to most patients, confirming that appropriate programming and sensor specificity is critical in rate responsive pacing.
Abundant bacteria shaped by deterministic processes have a high abundance of potential antibiotic resistance genes in a plateau river sediment (2022)

Recent research on abundant and rare bacteria has expanded our understanding of bacterial community assembly. However, the relationships of abundant and rare bacteria with antibiotic resistance genes (ARGs) remain largely unclear. Here, we investigated the biogeographical patterns and assembly processes of the abundant and rare bacteria from river sediment at high altitudes (Lhasa River, China) and their potential association with the ARGs. The results showed that the abundant bacteria were dominated by <i>Proteobacteria</i> (55.4%) and <i>Cyanobacteria</i> (13.9%), while the <i>Proteobacteria</i> (33.6%) and <i>Bacteroidetes</i> (18.8%) were the main components of rare bacteria. Rare bacteria with a large taxonomic pool can provide function insurance in bacterial communities. Spatial distribution of persistent abundant and rare bacteria also exhibited striking differences. Strong selection of environmental heterogeneity may lead to deterministic processes, which were the main assembly processes of abundant bacteria. In contrast, the assembly processes of rare bacteria affected by latitude were dominated by stochastic processes. Abundant bacteria had the highest abundance of metabolic pathways of potential drug resistance in all predicted functional genes and a high abundance of potential ARGs. There was a strong potential connection between these ARGs and mobile genetic elements, which could increase the ecological risk of abundant taxa and human disease. These results provide insights into sedimental bacterial communities and ARGs in river ecosystems.
Effects of indirect foraminal decompression during anterior cervical disc fusion procedure: a prospective study with clinical and radiological outcomes (2022)

Abstract Purpose The respective effects of direct and indirect decompression in the clinical outcome after anterior cervical disc fusion (ACDF) is still debated. The main purpose of this study was to determine whether the height of the implants was associated with postoperative foraminal height and volume, and with clinical improvement in patients suffering from cervico-brachial neuralgias due to degenerative foraminal stenosis. Methods We conducted a prospective follow-up of patients who underwent ACDF for cervicobrachial neuralgias due to degenerative foraminal stenosis. Patient had filled auto questionnaires (Neck Disability Index (NDI), Visual Analog Scales (VAS) for cervical and radicular pain) and performed a CT-scan pre and post-operatively. Disc height, foraminal height and foraminal volumes were measured pre and post operatively. Results 37 cervical disc fusions were successfully performed in 20 patients, with a total of 148 foramina studied. A significant improvement in the 3 scores was observed at 3 months postoperatively (p &lt; 0.001). We found a significant improvement in every radiological parameter, with a significant increase in disc height, foraminal height and foraminal volume being respectively + 3,22mm (p &lt; 0,001), + 2,12mm (p &lt; 0,001) and + 54mm 3 (p &lt; 0,001). Increase in disc height was significantly associated with increase in foraminal height (p &lt; 0,001) and foraminal volume (p &lt; 0,001). Increase in foraminal height was significantly correlated with foraminal volume (p &lt; 0,001) and with improvement in NDI score (p:0,037). Considering all those findings, our study suggests that indirect decompression helps in clinical improvement after ACDF. Conclusion This study provides interesting data regarding the clinical benefit of indirect decompression in ACDF performed for cervicobrachial neuralgias.
Efficacy and safety of dapagliflozin in addition to insulin therapy in Japanese patients with type 2 diabetes: Results of the interim analysis of 16‐week double‐blind treatment period (2015)

Dapagliflozin used as add-on treatment to insulin therapy showed significantly greater reduction of HbA1c, fasting plasma glucose and bodyweight without severe hypoglycemia compared with the placebo at week 16. These results show the clinical benefit of prescribing dapagliflozin for Japanese patients with insufficient glycemic control even with insulin therapy.
Heterogeneity Affecting Outcome From Acute Stroke Therapy (2001)

After examining these data in detail, we concluded that the presence of these clinical conditions could assist in identification of those at increased risk for complications of reperfusion therapy. Furthermore, consideration of these factors may provide a rational basis for combination therapy and improve the clinical relevance of experimental stroke models.
Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2α To Activate Productive Viral Replication (2018)

Kaposi's sarcoma (KS)-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8) causes the angiogenic tumor KS and two B-cell malignancies. The KSHV nonstructural membrane protein encoded by the open reading frame (ORF) K15 recruits and activates several cellular proteins, including phospholipase Cγ1 (PLCγ1), components of the NF-κB pathway, as well as members of the Src family of nonreceptor tyrosine kinases, and thereby plays an important role in the activation of angiogenic and inflammatory pathways that contribute to the pathogenesis of KS as well as KSHV productive (lytic) replication. In order to identify novel cellular components involved in the biology of pK15, we immunoprecipitated pK15 from KSHV-infected endothelial cells and identified associated proteins by label-free quantitative mass spectrometry. Cellular proteins interacting with pK15 point to previously unappreciated cellular processes, such as the endocytic pathway, that could be involved in the function of pK15. We found that the class II phosphatidylinositol 3-kinase (PI3K) PI3K-C2α, which is involved in the endocytosis of activated receptor tyrosine kinases and their signaling from intracellular organelles, interacts and colocalizes with pK15 in vesicular structures abundant in the perinuclear area. Further functional analysis revealed that PI3K-C2α contributes to the pK15-dependent phosphorylation of PLCγ1 and Erk1/2. PI3K-C2α also plays a role in KSHV lytic replication, as evidenced by the reduced expression of the viral lytic genes K-bZIP and ORF45 as well as the reduced release of infectious virus in PI3K-C2α-depleted KSHV-infected endothelial cells. Taken together, our results suggest a role of the cellular PI3K-C2α protein in the functional properties of the KSHV pK15 protein.<b>IMPORTANCE</b> The nonstructural membrane protein encoded by open reading frame K15 of Kaposi's sarcoma-associated herpesvirus (KSHV) (HHV8) activates several intracellular signaling pathways that contribute to the angiogenic properties of KSHV in endothelial cells and to its reactivation from latency. A detailed understanding of how pK15 activates these intracellular signaling pathways is a prerequisite for targeting these processes specifically in KSHV-infected cells. By identifying pK15-associated cellular proteins using a combination of immunoprecipitation and mass spectrometry, we provide evidence that pK15-dependent signaling may occur from intracellular vesicles and rely on the endocytotic machinery. Specifically, a class II PI3K, PI3K-C2α, is recruited by pK15 and involved in pK15-dependent intracellular signaling and viral reactivation from latency. These findings are of importance for future intervention strategies that aim to disrupt the activation of intracellular signaling by pK15 in order to antagonize KSHV productive replication and tumorigenesis.
Theoretical analysis of the mechanism of nitrous oxide release upon the UV irradiation of binuclear sulfur-containing nitrosyl iron complexes (2004)

The B3LYP calculations of binuclear sulfur-containing nitrosyl iron complexes reveal the possibility of photochemical NO ligand ‘coupling’, which results in the N–N bond formation followed by N2O release in subsequent transformations.
Methodological issues affecting the value of patient-reported outcomes data (2002)

The validity and value of patient-reported outcomes data are heavily dependent on the methods used to collect the data. This review examines the impact of a variety of methodological issues on the value of patient-reported outcome data. In particular, when patients are asked to self-monitor their experiences, disease episodes and healthcare utilization over time, a variety of methodological issues must be addressed if the data are to be considered a reliable and valid reflection of their daily lives. Ecological momentary assessment, a set of methods for collecting real-time data from patients in their natural environments, holds considerable promise as a way to enhance the value of certain types of patient-reported outcome data.
Subjective and objective analysis of three water pump systems carried by forest firefighters (2014)

It was recommended that the Prototype be implemented as the M3 carriage system for fire suppression teams.
Measurement of lateral dopant diffusion in thin silicide layers (1992)

The lateral diffusion of dopants in silicides was studied using a sensitive Schottky-barrier test structure that relies on changes in the I-V characteristic of a silicide-polysilicon interface due to dopant diffusion from the doped silicide into the polysilicon. The process flow of the test structure makes the device readily adaptable to all deposited or reacted silicides. The test structure was used to measure the diffusivity of B, As, and P in WSi/sub 2/, TiSi/sub 2/, and CoSi/sub 2/ at temperatures from 750 to 1000 degrees C. No measurable lateral diffusion of B in TiSi/sub 2/ was observed. In all the other cases, diffusion was several orders of magnitude higher than in silicon. These results should aid the development of process flows to prevent device degradation due to the lateral diffusion of dopants in the silicide layer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Advances in ptychographical coherent diffractive imaging (2008)

Extracting quantitative image information from coherent diffraction measurements remains challenging due to problems such as slow convergence of iterative phase retrieval algorithms, questionable uniqueness of the resulting images, and common requirements of compactness of the specimens. These difficulties are overcome by combining iterative phase retrieval with ptychography, i.e., the use of multiple diffraction measurements probing several overlapping regions of the specimen. While promising results of ptychographical coherent diffractive imaging have been achieved the technique has been limited by requiring precise knowledge of the illumination. We present advances of the reconstruction algorithm, which allow unsupervised deconvolution of the illuminating probe and the complex-valued optical transmission function of the specimen. We have performed measurements using both visible light and x-rays, demonstrating sub-50nm resolution.
ChemInform Abstract: Trimethylorthoformate: A Mild and Effective Dehydrating Reagent for Solution and Solid Phase Imine Formation. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The design and implementation of a declarative sensor network system (2007)

Sensor networks are notoriously difficult to program, given that they encompass the complexities of both distributed and embedded systems. To address this problem, we present the design and implementation of a declarative sensor network platform, DSN: a declarative language, compiler and runtime suitable for programming a broad range of sensornet applications. We demonstrate that our approach is a natural fit for sensor networks by specifying several very different classes of traditional sensor network protocols, services and applications entirely declaratively -- these include tree and geographic routing, link estimation, data collection, event tracking, version coherency, and localization. To our knowledge, this is the first time these disparate sensornet tasks have been addressed by a single high-level programming environment. Moreover, the declarative approach accommodates the desire for architectural flexibility and simple management of limited resources. Our results suggest that the declarative approach is well-suited to sensor networks, and that it can produce concise and flexible code by focusing on what the code is doing, and not on how it is doing it.
S. cerevisiae β-glucan reduced viability of mouse hepatoma cells in vitro (2015)

$\beta$-Glucan is a natural polymer, which is widely studied due to its multiple immunomodulatory properties. In addition, recent findings indicate potent antitumor properties of $\beta$-glucan. Saccharomyces cerevisiae, baker's yeast, is one of the commonly used sources of $\beta$-1,3-glucan. The aim of this work was to investigate S. cerevisiae $\beta$-glucan immunomodulatory activity against cancer cells.In our experiments, BALB/c mice were fed with insoluble whole $\beta$-glucan particles, and then their blood was collected for experiments. MH-22a hepatoma cells were treated with the blood of mice fed with $\beta$-glucan, and tumor cell viability was investigated after the treatment.The obtained results demonstrated that leukocytes in vivoprimed with whole glucan particles, in combination with soluble $\beta$-glucan, decreased MH-22a hepatoma cell viabilityin vitro.Our study has indicated that $\beta$-glucan obtained from S. cerevisiae potentially primes mouse whole blood leukocytes to induce cell death of mouse hepatoma cells.
Investigation of the Phase Separation Occurring during the Injection of β-Tricalcium Phosphate – Water – Glass Beads Pastes (2011)

Tests were performed to assess the parameters influencing the injectability of cement pastes loaded with large particles, such as porogens or drug-delivery agents. The use of non-setting model pastes permitted to demonstrate that two phase separation mechanisms occurred simultaneously, i.e. the separation between liquid and powder, known as filter-pressing phenomenon, and the separation between larger and smaller particles.
Socio-Spatial Comfort (2021)

A well-designed workplace has a direct and significant impact on our work experiences and productivity. In this paper, we investigate how office interior layouts influence the way we socially experience office buildings. We extend the previous work that examined static social formations of office workers by looking at their dynamic movements during informal desk visiting interactions. With a month of video data collected in the office, we implemented a vision-based analysis system that enables us to examine how people occupy space in social contexts in relation to desk configurations. The results showed that both social territoriality and approach path highlight social comfort in human-building interactions, which are different from efficiency or path optimization. From these findings, we propose the concepts of socio-spatial comfort: social buffers, privacy buffers, and varying proxemics to inform a user-centered way of designing human building interactions and architecture.
395: Expression Analysis of NDRG1, An Androgen-Induced, Stress Responsive Gene, in Prostate Cancer (2005)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 22, 2005 1:00 - 5:00 pm1 Apr 2005395: Expression Analysis of NDRG1, An Androgen-Induced, Stress Responsive Gene, in Prostate Cancer Toru Yoshida, Takehiko Segawa, Takahiro Inoue, Yosuke Shimizu, Toshiyuki Kamoto, Taizo Shiraishi, Shiv Srivastava, Judd W. Maul, and Osamu Ogawa Toru YoshidaToru Yoshida More articles by this author , Takehiko SegawaTakehiko Segawa More articles by this author , Takahiro InoueTakahiro Inoue More articles by this author , Yosuke ShimizuYosuke Shimizu More articles by this author , Toshiyuki KamotoToshiyuki Kamoto More articles by this author , Taizo ShiraishiTaizo Shiraishi More articles by this author , Shiv SrivastavaShiv Srivastava More articles by this author , Judd W. MaulJudd W. Maul More articles by this author , and Osamu OgawaOsamu Ogawa More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34648-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "395: Expression Analysis of NDRG1, An Androgen-Induced, Stress Responsive Gene, in Prostate Cancer." The Journal of Urology, 173(4S), p. 108 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 108 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Toru Yoshida More articles by this author Takehiko Segawa More articles by this author Takahiro Inoue More articles by this author Yosuke Shimizu More articles by this author Toshiyuki Kamoto More articles by this author Taizo Shiraishi More articles by this author Shiv Srivastava More articles by this author Judd W. Maul More articles by this author Osamu Ogawa More articles by this author Expand All Advertisement PDF DownloadLoading ...
Prevention of Hypoglycemia During Exercise in Children With Type 1 Diabetes by Suspending Basal Insulin (2006)

Discontinuing basal insulin during exercise is an effective strategy for reducing hypoglycemia in children with type 1 diabetes, but the risk of hyperglycemia is increased.
Carnosol induces the osteogenic differentiation of bone marrow-derived mesenchymal stem cells via activating BMP-signaling pathway (2021)

Carnosol is a phenolic diterpene phytochemical found in rosemary and sage with reported anti-microbial, anti-oxidant, anti-inflammatory, and anti-carcinogenic activities. This study aimed to investigate the effect of carnosol on the lineage commitment of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) into osteoblasts and adipocytes. Interestingly, carnosol stimulated the early commitment of mBMSCs into osteoblasts in dose-dependent manner as demonstrated by increased levels of alkaline phosphatase activity and Alizarin red staining for matrix mineralization. On the other hand, carnosol significantly suppressed adipogenesis of mBMSCs and downregulated both early and late markers of adipogenesis. Carnosol showed to induce osteogenesis in a mechanism mediated by activating BMP signaling pathway and subsequently upregulating the expression of BMPs downstream osteogenic target genes. In this context, treatment of mBMSCs with LDN-193189, BMPR1 selective inhibitor showed to abolish the stimulatory effect of carnosol on BMP2-induced osteogenesis. In conclusion, our data identified carnosol as a novel osteoanabolic phytochemical that can promote the differentiation of mBMSCs into osteoblasts versus adipocytes by activating BMP-signaling.
Synthesis and characterization of polymer embedded iron oxide nanocomposites (2009)

Abstract Optical plastics filled by nano‐sized magnetic particles may have relevant applications in magneto‐optics. Here, an in‐situ method for the preparation of magnetic nanoparticles embedded in polystyrene by thermal decomposition of iron mercaptide is described. Transparent ferromagnetic and superparamagnetic nanocomposites have been produced using iron (II) and iron (III) mercaptides. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2774–2777, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24733