gebhart/patrepeval huggingface dataset:
Local Elongation of Endothelial Cell-anchored von Willebrand Factor Strings Precedes ADAMTS13 Protein-mediated Proteolysis (2011)

Platelet-decorated von Willebrand factor (VWF) strings anchored to the endothelial surface are rapidly cleaved by ADAMTS13. Individual VWF string characteristics such as number, location, and auxiliary features of the ADAMTS13 cleavage sites were explored here using imaging and computing software. By following changes in VWF string length, we demonstrated that VWF strings are cleaved multiple times, successively shortening string length in the function of time and generating fragments ranging in size from 5 to over 100 μm. These are larger than generally observed in normal plasma, indicating that further proteolysis takes place in circulation. Interestingly, in 89% of all cleavage events, VWF strings elongate precisely at the cleavage site before ADAMTS13 proteolysis. These local elongations are a general characteristic of VWF strings, independent of the presence of ADAMTS13. Furthermore, large elongations, ranging in size from 1.4 to 40 μm, occur at different sites in space and time. In conclusion, ADAMTS13-mediated proteolysis of VWF strings under flow is preceded by large elongations of the string at the cleavage site. These elongations may lead to the simultaneous exposure of many exosites, thereby facilitating ADAMTS13-mediated cleavage.
Risk Assessment and Training about Type-2 Diabetes on the Internet. (1997)

Hepatitis C virus(HCV) genotype is one of the most important predicting factors of response to interferon(IFN) therapy in patients with chronic hepatitis C. According to the molecular evolutionary analysis, HCV is classified into six major genotypes. The patients infected with genotype 1 show high HCV RNA levels and poor response to IFN therapy compared to those with genotype 2 or 3. No sufficient data are observed on response to IFN in patients with genotype 4 to 6. When PEG-IFN plus ribavirin therapy is introduced, high proportion of patients without genotype 1 must show complete response. In the near future, to predict good response to IFN therapy, it will be necessary to know whether patients have HCV genotype 1 or not.
Cholesteryl Ester Transfer Protein Inhibition in Cardiovascular Risk Management: Ongoing Trials will End the Confusion (2010)

As delineated in this review, cholesteryl ester transfer protein (CETP) contributes to an atherogenic lipoprotein profile by redistributing cholesteryl esters from high density lipoprotein (HDL) toward apolipoprotein B-containing lipoproteins, especially when the concentration of acceptor triglyceride-rich lipoproteins is elevated. However, this lipid transfer protein may have antiatherogenic proprerties as well. Experimental evidence is accumulating which suggests that the atheroprotective reverse cholesterol transport pathway, whereby cholesterol is removed from peripheral macrophages to the liver for metabolism and biliary excretion, is stimulated by CETP in vivo. CETP could also play a role in host defense against infection and inflammatory processes. Moreover, recently published observational studies show that higher CETP levels may confer cardiovascular protection, whereas reported associations of cardiovascular disease (CVD) with CETP gene variations are equivocal. The concept that HDL cholesterol raising through inhibition of CETP may ameliorate CVD risk has been challenged by the failure of the CETP inhibitor, torcetrapib. Adverse clinical outcome associated with the use of this CETP inhibitor has been attributed to off-target effects, which relate to stimulation of aldosterone. Other CETP inhibitors, such as dalcetrapib and anacetrapib, are unlikely to increase blood pressure. Dalcetrapib is less potent than anacetrapib, which doubles HDL cholesterol. Both inhibitors considerably lower LDL cholesterol.Serious concerns remain about the validity of the concept that HDL cholesterol raising by means of CETP inhibition is a viable strategy. Results of ongoing clinical trials with these drugs will have to be awaited before making up the balance between possible benefits and harms related to pharmacological CETP inhibition.
The Utility of Sulfonylhydrazines in the Study and Potential Treatment of African Sleeping Sickness (2021)

African sleeping sickness is an invariably fatal disease caused by Trypanosoma brucei group trypanosomes and transmitted by the bite of a Tsetse fly. In the human bloodstream, there are two main forms: long slender rapidly proliferating forms and biochemically distinct, non-proliferating short stumpy forms. These short stumpy forms are preadapted for life in the Tsetse fly gut and cannot sustain or initiate infection in the mammalian host. It was observed that exposure of long slender bloodstream trypomastigotes to a wide range of methylating agents could induce the entire population to differentiate into short stumpy forms. The methylators varied in their nucleophile preference from hard oxygen targets to soft thiol targets. Despite this wide variability, the methylators were all almost equivalently active. It was therefore assumed that the salient target was likely nitrogen of intermediate hardness/softness which would be equivalently targeted by both groups of methylators. A number of sulfonylhydrazine methylators including prodrug forms, with improved biological distribution in animals, were synthesized. In addition, some amidine moiety containing methylators were also synthesized to exploit the propensity of long slender trypanomastigotes to accumulate agents containing this chemical group, in an attempt to enhance their efficacy. These agents may be of utility in the study of differentiation in T. brucei group trypanosomes, and the production of large quantities of short stumpy forms for biochemical studies. Additionally, they could have therapeutic potential in the treatment of late-stage African sleeping sickness.
Solar cell efficiency tables (Version 60) (2022)

Abstract Consolidated tables showing an extensive listing of the highest independently confirmed efficiencies for solar cells and modules are presented. Guidelines for inclusion of results into these tables are outlined, and new entries since January 2022 are reviewed. An appendix describing temporary electrical contacting of large‐area solar cells approaches and terminology is also included.
Lysine Availability in Flash-Dried Blood Meals for Swine (1985)

The available lysine content of three flash-dried blood meals was determined by use of a pig growth assay. Pigs that were 5 to 6 wk old were fed either one of the reference diets or one of the test diets for the 4-wk period of each assay. The reference diets were a corn-soybean meal basal (B) that was deficient in lysine, B+.1% L-lysine and B+.2% L-lysine. The test diets were B plus 1.5% and 3.0% of blood meal. The available lysine levels (percentage as fed) of ring-dried cattle blood meal, ring-dried swine blood meal and drum-dried cattle blood meal were determined to be 6.9, 7.4 and 6.7, respectively. All three flash-dried blood meals appeared to have similar available lysine levels and a value of 7% lysine may be used to formulate diets containing flash-dried blood meals. Incorporation of 3 or 6% drum-dried blood meal into starter diets improved N retention over a corn-soybean meal diet and did not reduce N-corrected metabolizable energy density of the diet.
Reliability and validity of a partial weight bearing measure of lower extremity performance. (2009)

Using the incline apparatus yielded reliable PWB data. In addition, performance on the PWB measures correlated fairly well with common measures of function.
The characterization of the EBV alkaline deoxyribonuclease cloned and expressed inE.coli (1989)

Studies of nucleic acid homology suggest the BGLF5 open reading frame of Epstein-Barr virus (EBV) encodes an alkaline deoxyribonuclease (DNase) sharing some homology with that of herpes simplex virus. We report here the expression of the BGLF5 open reading frame in E. coli and the expression of high levels of a novel alkaline DNase activity in induced cells. This alkaline DNase has been purified to apparent homogeneity as a single protein species. This is the first report of the expression of a herpesvirus coded DNase in a prokaryotic system and of the purification of the EBV DNase to demonstrable purity. It has the biochemical characteristics of a typical herpesvirus alkaline exonuclease showing a high pH optimum, an absolute requirement for Mg2+ for activity and sensitivity to high salt concentrations and polyamines. The enzyme activity was neutralized by sera from patients with nasopharyngeal carcinoma and was reactive with these sera in Western blot analysis. Thus the prokaryotic expression system described here provides an economical and efficient source of the EBV DNase for biochemical and seroepidemiological analysis.
Grey matter injury patterns in cerebral palsy: associations between structural involvement on MRI and clinical outcomes (2015)

Better understanding of structure-function relationships in CP and GMI, and how to rate the severity of GMI, will be helpful in the clinical context and also as a basis for investigation of causal pathways in CP.
Alquimia, minería y cultura popular en las obras de los Barones de Beausoleil: los habitantes de los mundos subterráneos (2013)

Martine de Bertereau and Jean de Chastelet, baroness and baron of Beausoleil, miners and alchemists, were active in France and in the mining districts of Central Europe in the first half of the seventeenth century. In this contribution we have studied their works in aspects concerning the belief in the existence of dwarfs or demons in the underground world. For this purpose, we have compared their opinions with what other sources say, both prominent authors, coming from academic circles (Trithemius, Agricola, Lavater, Del Rio, Kircher), and anonymous miners, whose opinions have survived in official documents and reports. From this analysis we conclude that the Beausoleil’s view on these demons is strongly shaped by scholar knowledge as well as by the popular culture and traditions then strongly rooted among the mining European populations.
NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease (2020)

Granulocytes from patients with chronic granulomatous disease (CGD) have dysfunctional phagocyte reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase that fails to generate sufficient antimicrobial reactive oxidative species. CGD patients with severe persistent fungal or bacterial infection who do not respond to antibiotic therapy may be given apheresis-derived allogeneic granulocyte transfusions from healthy volunteers to improve clearance of intractable infections. Allogeneic granulocyte donors are not HLA matched, so patients who receive the donor granulocyte products may develop anti-HLA alloimmunity. This not only precludes future use of allogeneic granulocytes in an alloimmunized CGD recipient, but increases the risk of graft failure of those recipients who go on to need an allogeneic bone marrow transplant. Here, we provide the first demonstration of efficient functional restoration of CGD patient apheresis granulocytes by messenger RNA (mRNA) electroporation using a scalable, Good Manufacturing Practice-compliant system to restore protein expression and NADPH oxidase function. Dose-escalating clinical-scale in vivo studies in a nonhuman primate model verify the feasibility, safety, and persistence in peripheral blood of infusions of mRNA-transfected autologous granulocyte-enriched apheresis cells, supporting this novel therapeutic approach as a potential nonalloimmunizing adjunct treatment of intractable infections in CGD patients.
Sirolimus eluting stent in the treatment of atherosclerosis coronary artery disease. (2002)

Stent implantation represents the most commonly performed percutaneous coronary intervention nowadays. However, instent restenosis due to exaggerated neointimal hyperplasia remains a problem to overcome. Neointimal hyperplasia is a vascular response to stent injury; it mainly consists of smooth muscle cells proliferation. The underlying molecular mechanisms of restenosis were explained in this review article. Recently, drug-eluting stent has been proposed as a potential method to prevent instent restenosis. Animal studies have confirmed safety and efficacy of sirolimus-eluting stent implantation in vivo. The FIM trial, which was the first clinical study on sirolimus-eluting stent in de novo lesions, has shown an astonishing 0% restenosis rate. The RAVEL trial was the first prospective, double-blind, multi-center trial that randomized 238 patients at 19 institutions with de novo lesions into sirolimus-eluting versus bare Bx velocity stent. Six-month binary restenosis rate in the sirolimus-group was again 0% compared to 26.6% in the control group. Angiographic late loss and major cardiac event were also significantly lower in the sirolimus-group. The SIRIUS trial is an ongoing study conducted in 53 US centers that randomized 1100 patients with de novo lesion into sirolimus-eluting and bare stents. Preliminary results also showed a significant reduction in binary restenosis, late loss and repeat revascularization rates. Apart from de novo lesions, early experience of sirolimus-eluting stent implantation for instent restenosis in non-randomized study was also promising, achieving a single-digit repeat restenosis rate. As compare with standard coronary stent, a sirolimus-eluting stent shows considerable promise for the prevention of neointimal proliferation, restenosis and associated clinical events.
Antimicrobial resistance trends of non-fermenter Gram negative bacteria in Saudi Arabia: A six-year national study (2021)

We are reporting high and/or increasing resistance of NFGNB to common treatment options. The current findings call for urgent actions to combat the increasing resistance of NFGNB. Large scale sharing of AMR data collected at different hospitals with the Saudi AMR committee would be critical to set priorities and monitor progress.
OPCAB Compared with Conventional CABG in Patients Receiving More than One Bypass Graft (2018)

Objective: Recent studies report no significant benefit for the operative treatment of coronary heart disease in Off-pump surgery (OPCAB). We compare our patient collective undergoing coronary artery bypass grafting (CABG) during the past 7 years.
Zero-Shot Open Entity Typing as Type-Compatible Grounding (2019)

The problem of entity-typing has been studied predominantly in supervised learning fashion, mostly with task-specific annotations (for coarse types) and sometimes with distant supervision (for fine types). While such approaches have strong performance within datasets, they often lack the flexibility to transfer across text genres and to generalize to new type taxonomies. In this work we propose a zero-shot entity typing approach that requires no annotated data and can flexibly identify newly defined types. Given a type taxonomy defined as Boolean functions of FREEBASE "types", we ground a given mention to a set of type-compatible Wikipedia entries and then infer the target mention's types using an inference algorithm that makes use of the types of these entries. We evaluate our system on a broad range of datasets, including standard fine-grained and coarse-grained entity typing datasets, and also a dataset in the biological domain. Our system is shown to be competitive with state-of-the-art supervised NER systems and outperforms them on out-of-domain datasets. We also show that our system significantly outperforms other zero-shot fine typing systems.
Calculation of sediment and scour of Sanmenxia reservoir in flood season by the BP neural network improved by GA (2005)

In this paper, the problems of slow convergence speed and being prone to converge to minimum are solved by combining the characteristics of global optimization of GA (Genetic Algorithm) with local optimization of BP neural network, the calculation accuracy and convergence rate of BP neural network are improved.The sediment and scour of Sanmenxia reservoir in flood season are calculated and predicted by this model and BP neural network. Compared with normal BP neural network, the numerical results of BP neural network improved by GA show that the average errors of calculation and prediction are diminished and the iterative numbers are much less than that of the normal BP neural network. Thus the BP neural network improved by GA is suitable to solve nonlinear problems such as calculation of sediment and scour of reservoirs.
Application of Biocides and Chemical Treatments to Both Combat Microorganisms and Reduce (Bio)Corrosion (2017)

230The recognition of biocorrosion, or microbially influenced corrosion, as a problem has increased over the last several decades in the oil and gas industry, with an estimated 15–30% of all corrosion incidents being attributed to the metabolic activity of microorganisms. However, corrosion in general still plagues the industry. Exact costs of repairs and lost revenue due to unexpected infrastructure failure or shutdown are not readily available, but are easily estimated to run into the U.S. billion dollar range. Slowing or reducing both abiotic and biotic corrosion processes can greatly extend the longevity of the assets and reduce the incidence of failure in the system, routinely through the use of performance chemicals such as corrosion inhibitors, biocides, or sulfide scavenging chemistries. Corrosion-resistant alloys may also be used to provide longer-term protection for new installations, but their cost is typically prohibitive for large-scale applications or installations. In this chapter, we discuss the performance and functionality of common oilfield chemicals used to combat abiotic and biotic corrosion. Background information is provided on the different chemistries, and comparisons are made on the performance and efficacy of each under different field conditions. The chapter provides several examples of chemical application strategies and ends with suggestions on how to implement meaningful KPIs for monitoring biotic and abiotic corrosion processes in the oil and gas industry.
Yeast strains role on the sulphur dioxyde combinations of wines obtained from noble rot and raisining grapes (2000)

&lt;p style="text-align: justify;"&gt;The influence of four industrial and indigenous yeast strains on the sulphur dioxide combinations of wines obtained from noble rot and raisining grapes is studied in different growth of the Sauternes area and one growth in the Jurançon area. The analysis of ketonic compounds (pyruvic acid and 2-oxo-glutaric acid), acetaldehyde and PC50 on the wines clearly showed significant statistical difference between the yeast strains for the sulphur dioxide combination. By adding the same dosage of sulphiting, the free SO&lt;sub&gt;2&lt;/sub&gt; levels are variable depending on the yeast strain used. One strain (Zymaflore ST), isolated from a spontaneous fermentation of a botrytised must, giving wines with low PC50 values, is well adapted for the noble rot must vinification. The choice of the yeast strain is a parameter of importance to limit the sulphur dioxide amount in the wines.&lt;/p&gt;
Reactions of molten urea with formaldehyde (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of molten urea with formaldehydeThomas P. Murray, Ernest R. Austin, Robert G. Howard, and Timothy J. BradfordCite this: Ind. Eng. Chem. Prod. Res. Dev. 1985, 24, 3, 420–425Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://doi.org/10.1021/i300019a017Request reuse permissionsArticle Views302Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (706 KB) Get e-Alerts
A neomorphic mutation in the interferon activation domain of IRF4 causes a dominant primary immunodeficiency (2023)

Here, we report on a heterozygous interferon regulatory factor 4 (IRF4) missense variant identified in three patients from a multigeneration family with hypogammaglobulinemia. Patients' low blood plasmablast/plasma cell and naïve CD4 and CD8 T cell counts contrasted with high terminal effector CD4 and CD8 T cell counts. Expression of the mutant IRF4 protein in control lymphoblastoid B cell lines reduced the expression of BLIMP-1 and XBP1 (key transcription factors in plasma cell differentiation). In B cell lines, the mutant IRF4 protein as wildtype was found to bind to known IRF4 binding motifs. The mutant IRF4 failed to efficiently regulate the transcriptional activity of interferon-stimulated response elements (ISREs). Rapid immunoprecipitation mass spectrometry of endogenous proteins indicated that the mutant and wildtype IRF4 proteins differed with regard to their respective sets of binding partners. Our findings highlight a novel mechanism for autosomal-dominant primary immunodeficiency through altered protein binding by mutant IRF4 at ISRE, leading to defective plasma cell differentiation.