gebhart/patrepeval huggingface dataset:
Self-assembled benzoxazine-bridged polysilsesquioxanes exhibiting ultralow-dielectric constants and yellow-light photoluminescent emission (2011)

A benzoxazine-bridged bis(triethoxysilane) compound (Bz-BES) has been prepared using bisphenol-A, paraformaldehyde, and 3-aminopropyltriethoxysilane as precursors. Characterization of Bz-BES has been conducted with Fourier transform infrared, nuclear magnetic resonance, molecular mass, and elemental analysis. Thermally cured polybenzoxazine-bridged polysilsesquioxane (PBz-BPSSQ) was obtained via the sol–gel and thermal treatment process of Bz-BES. PBz-BPSSQ shows a layer-by-layer lamellar structure composed of polybenzoxazine-rich and polysilsesquioxane-rich layers in the thickness of about 80–100 nm, resulting in its ultra-low dielectric constant of about 1.57 at 1 MHz. PBz-BPSSQ also displays a high glass transition temperature of about 295 °C and a Young's modulus of about 3.1 GPa, both are attributed to its highly cross-linked structure. Moreover, PBz-BPSSQ exhibits yellow-light photoluminescent emission at about 540 nm under excitation at 365 nm.
RNA‐unwinding and RNA‐folding Activities of RNA Helicase II/Gu — Two Activities in Separate Domains of the Same Protein (1997)

The human RNA helicase II/Gu protein (RH-II/Gu) is a member of the D-E-A-D box protein family. It is a unique enzyme, which possesses an ATP-dependent RNA-unwinding activity and has an RNA-folding activity that introduces an intramolecular secondary structure in single-stranded RNA. This report shows that these two enzymatic activities are distinct. ATP[S], GTP and low concentrations of ATP enhance the RNA-folding activity of RH-II/Gu but not the RNA-helicase activity. High concentrations of ATP are required for the helicase activity but are inhibitory to the RNA-folding activity. Mg2+ is required for the helicase activity but not for the RNA-folding reaction. Affinity-purified anti-(RH-II/Gu) polyclonal Ig inhibit the RNA-unwinding activity but not the folding activity. Mutations of the DEVD sequence, which corresponds to the DEAD box, and the SAT motif enhanced RNA-folding activity of RH-II/Gu but completely inhibited the RNA-helicase activity. A mutant that lacks the COOH-terminal 76 amino acid residues, including the four FRGQR repeats, had unwinding activity but did not catalyze the folding of a single-stranded RNA. The two enzymatic activities of RH-II/Gu reside in distinct domains. Amino acids 1-650 are active in the RNA-unwinding reaction but lack RNA-folding activity. Amino acids 646-801 fold single-stranded RNA but lack helicase activity. This report shows distinct RNA-unwinding and RNA-folding activities residing in separate domains within the same protein.
Increased Production of Extracellular Glutamate by the Mitochondrial Glutaminase following Neuronal Death (1997)

Elevated extracellular concentrations of the excitatory transmitter glutamate are an important cause of neuronal death in a variety of disorders of the nervous system. The concentrations and rates of clearance and production of extracellular glutamate were measured in the medium of primary cultures from mouse neocortex containing neurons, astrocytes, or both cell types. Measurements were performed in the presence and absence of 2 mM glutamine with or without neuronal injury caused by 5-h exposure to hypoxia or 500 microM N-methyl-D-aspartate or a freeze-thaw cycle. High rates of glutamate generation (0.5-0.8 microM/min in the 0.4-ml culture well) occurred if neurons were both damaged and exposed to glutamine. Intact neurons or glia exposed to glutamine generated only small amounts of glutamate (0.03 microM/min). Glutamate generation by damaged neurons was dependent on the presence of glutamine, activated by phosphate, and inhibited by 6-diazo-5-oxo-L-norleucine and p-chloromercuriphenylsulfonic acid (pCMPS), strongly implicating the mitochondrial glutaminase. Following 5-h exposure to 500 microM N-methyl-D-aspartate, the glutaminase was localized to fragments of damaged neurons and was accessible to inhibition by the membrane-impermeant pCMPS. The glutaminase activity from damaged neurons is sufficient to account for the neurotoxic concentrations of glutamate in hypoxic mixed neuronal-glial cultures exposed to 2 mM glutamine. Finally, pCMPS is neuroprotective and also prevents the increased rate of generation of glutamate observed in neuronal cultures after prolonged exposure to glutamine. The cumulative data indicate the following: 1) excitotoxic neuronal death activates the hydrolysis of extracellular glutamine by the mitochondrial glutaminase, and 2) the glutaminase in damaged neurons is sufficient to cause neuronal death in in vitro models of neuronal injury.
Superior efficacy with a fixed‐ratio combination of insulin degludec and liraglutide (IDegLira) compared with insulin degludec and liraglutide in insulin‐naïve Japanese patients with type 2 diabetes in a phase 3, open‐label, randomized trial (2019)

IDegLira was superior to degludec and liraglutide in terms of HbA1c reduction and superior to degludec in terms of body weight change and rates of hypoglycaemia in Japanese people with T2D.
Context-aware physical layer security for future wireless networks (2022)

The amount information currently generated and contained in wireless networks is paramount. Additionally, wireless sensing through integrated sensing and communication (ISAC) is being incorporated into the next-generation [B5G, WiFi 7] wireless communication standards, further increasing this information. Faster chips, various network topologies and higher data rates have permitted increased utilization of artificial intelligence (AI) techniques in wireless systems and thus enable accurate predictions of future network and radio environment related phenomenon. Therefore, a capable device can essentially be aware of the user, network, and radio environment activities. These developments have led to the cognitive or context-aware physical layer security (PLS) concept. With this, intelligent wireless devices can anticipate threats and take the necessary precautions dynamically. This chapter will go over radio environment monitoring (REMo), which is the process of collecting, processing and storing the aforementioned information. Then, the context-aware PLS framework will be introduced, with application examples.
Human Chorionic Gonadotropin Adjuvant Therapy for Patients with Leydig Cell Dysfunction After Varicocelectomy (1995)

The authors treated 135 men who underwent varicocelectomy, but had sustained Leydig cell dysfunction disclosed by LHRH test with human chorionic gonadotropin (hCG). hCG was administered for 10 weeks: 50,000 units were given in 10 divided doses intramuscularly. Semen analysis and measurement of serum hormone level were obtained 8 weeks after the completion of treatment, and every 3 months after that. All patients were followed up for 2 years to confirm pregnancy. Fifty-five percent of patients achieved pregnancy and they showed significant increase in sperm density, percentage of sperm motility, normal form sperm, and serum testosterone level. It is recommended that hCG be administered to patients who undergo varicocelectomy but have persistent subtle Leydig cell dysfunction disclosed by LHRH test to stimulate the intratesticular testosterone production.
New Insights in the Electrocatalytic Proton Reduction and Hydrogen Oxidation by Bioinspired Catalysts: A DFT Investigation (2010)

In this paper, we present a DFT study of the proton reduction mechanism catalyzed by the complex [Ni(P₂(H)N₂(H))₂](2+), bioinspired from the hydrogenases. A detailed analysis of the reactive isomers is discussed together with the localizations of the transitions states and energy minima. The reactive catalytic species is a biprotonated Ni(0) complex that can show different conformations and that can be protonated on different sites. The energies of the different conformations and biprotonated species have been calculated and discussed. Energy barriers for two different reaction mechanisms have been identified in solvent and in gas phase. Frequency calculations have been performed to check the nature of the energy minima and for the calculations of entropic energetic terms and zero point energies. We show that only one conformation is mostly reactive. All the others species are nonreactive in their original form, and they have to pass through conformational barriers in order to transform in the reactive species.
[Lasers in otologic surgery]. (1993)

The author makes known the possible advantages of the laser-application in the ear surgery. He informs about the main tissue effects of the surgical lasers used in practice. On the bases of the bibliography and his own experiences the author offers a survey of the indications of laser-oto-surgery.
Planar lightwave circuit polarization-mode dispersion compensator (2002)

In this letter, we fabricated an integrated polarization-mode dispersion compensator on a silica-based planar lightwave circuit that incorporated an endless polarization controller and a fixed polarization dependent delay line. The compensator consisted of polarization beam splitters, thermooptic phase shifters, tunable couplers, and polarization converters. We experimentally confirmed its operation at a data rate of 43 Gb/s.
Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction (2016)

This study suggests that paroxetine is effective for improving cardiac function in patients with AMID and such effect correlates with GRK2 reduction.
Nealkogol'naya zhirovaya bolezn' pechenipri ozhirenii (2011)

Non-alcoholic fatty liver disease (NAFLD) is a common chronic disease, uniting clinical and pathological changes in a liver: steatosis, non-alcoholic steatohepatitis, fibrosis and cirrhosis. NAFLD is associated with obesity especially of abdominal type and metabolic syndrome, that raises cardiometabolic risk and effects morbidity, prognosis of the disease and life expectancy of patients. This article describes the basic mechanisms of development of NAFLD, classification, prognosis of the disease, diagnosis and treatment.
Spontaneous emission of Bloch oscillation radiation under the competing influences of microcavity enhancement and inhomogeneous interface degradation (2014)

A theory for the spontaneous emission (SE) of terahertz radiation for a Bloch electron traversing a single energy miniband of a superlattice (SL) in a cavity, while undergoing elastic scattering is presented. The Bloch electron is accelerated under the influence of a superimposed external constant electric field and an internal inhomogeneous electric field, while radiating into a microcavity. The analysis of the SE accounts for both the spectral structure of nonharmonic miniband components and the Bloch oscillation degradation effects arising from elastic scattering due to SL interface roughness. The interface roughness effects are decomposed into contributions arising from independent planar and cross-correlated neighboring planar interfaces; parametric numerical estimates show that the cross-correlated contribution to the SE relaxation rate is relatively small, representing less than roughly 10% of the total relaxation rate. It is shown that the degradation effects from SL interface roughness can be more than compensated for by the enhancements derived from microcavity-based tuning of the emission frequency to the cavity density of states peak. The theoretical approach developed herein has general applicability beyond its use for elastic scattering due to interface roughness. As well, the results obtained in this analysis can be useful in the development of SL-based Bloch-oscillator terahertz devices.
A 2-Year Prospective Study of Patients from Castle Peak Hospital Discharged to the First Long-Stay Care Home in Hong Kong (2001)

Investigated the cost-effectiveness of the first psychiatric long-stay care home in Hong Kong, which opened in 1990. This was a prospective cohort study of the first 43 patients (aged 21-79 yrs) discharged to the long-stay care home from Castle Peak Hospital, who were followed-up for 2 years. Patients had significantly improved social and community skills while remaining behaviourally and symptomatically stable. The long-stay care home provided a less restrictive environment than Castle Peak Hospital, and patients' satisfaction was high. The recurring costs for the long-stay care home were lower than for the hospital. The only statistically significant adverse finding was deterioration in personal health care skills 2 years after leaving the medical setting. This study provides the first scientific evidence in Hong Kong to show that the long-stay care home is a cost-effective means of successfully rehabilitating a group of long-stay mental hospital inpatients who do not qualify for halfway houses but require only minimal nursing care (less than 2.5 hours per week). (PsycINFO Database Record (c) 2012 APA, all rights reserved)
ChemInform Abstract: Basic Coordination Chemistry of Technetium (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Study on the Nitrogen Desorption Reaction of Liquid Iron and Steel (1971)

Kinetics of nitrogen desorption reaction of liquid iron and steel has been investigated by means of blowing various gas on the surface of the melt.The nitrogen desorption reaction of liquid iron is of second order, and the reaction rate is remarkably affected by oxygen content in liquid iron.The rate constant decreases in inverse proportion to the second power of oxygen content above 0.03%, increases gradually below this value of oxygen content and tends to approach a constant value below 0.01% of oxygen.From the standpoint of chemisorption of nitrogen atoms on the surface of liquid iron, these results lead to the conclusion that the rate-controlling step is the reaction between these atoms, which is disturbed by adsorbed oxygen atoms.The activation energy of nitrogen desorption reaction is 39 kcal/mole in liquid iron containing oxygen less than 001%.When the decarburization and the nitrogen desorption reactions proceed simultaneously by blowing argon and oxygen mixed gas to liquid steel, the latter reaction is deviated from the second order, and its rate becomes considerably slow in comparison with that of liquid iron by blowing only argon. These facts are considered to be caused by the disturbance of the reaction of nitrogen atoms by the oxygen atoms adsorbed on the surface of liquid steel.
ALIGNMENT OPTIONS FOR KNEE REPLACEMENT: CURRENT EVIDENCE (2017)

The mechanical alignment (MA) for Total Knee Arthroplasty (TKA) with neutral alignment goal has had good overall long-term outcomes. In spite of improvements in implant designs and surgical tools aiming for better accuracy and reproducibility of surgical technique, functional outcomes of MA TKA have remained insufficient. Therefore, alternative, more anatomicaloptions restoring part (adjusted MA (aMA) and adjusted kinematic alignment (aKA) techniques) or the entire constitutional frontal deformity (unicompartment knee arthroplasty (UKA) and kinematic alignment (KA) techniques) have been developed, with promising results. The kinematic alignment for TKA is a new and attractive surgical technique enabling a patient specific treatment. The growing evidence of the kinematic alignment mid-term effectiveness, safety and potential short falls are discussed in this paper. The current review describes the rationale and the evidence behind different surgical options for knee replacement, including current concepts in alignment in TKA. We also introduce two new classification systems for “implant alignments options” (Figure 1) and “osteoarthritic knees” (Figure 2) that would help surgeons to select the best surgical option for each patient. This would also be valuable for comparison between techniques in future research.

For figures/tables, please contact authors directly.
Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation. (1988)

The human 4F2 cell surface antigen is a 120-kilodalton (kDa) disulfide-linked heterodimer which is composed of an 80- to 90-kDa glycosylated heavy chain (4F2HC) and a 35- to 40-kDa nonglycosylated light chain (4F2LC). 4F2 belongs to a family of inducible cell surface molecules which are involved in T-lymphocyte activation and growth. To better understand the molecular mechanism(s) that controls 4F2HC gene expression in both resting and activated T cells, a 4F2HC human genomic clone was isolated and structurally characterized. The 4F2HC gene spans 8 kilobases of chromosome 11 and is composed of nine exons. The 5' upstream region of the gene displays several properties which are characteristic of housekeeping genes. It is G+C rich and hypomethylated in peripheral blood lymphocyte DNA and contains multiple binding sites for the Sp1 transcription factor while lacking TATA or CCAAT sequences. This region of the gene also displays sequence homologies with several other inducible T-cell genes, including the interleukin-2, interleukin-2 receptor alpha chain, dihydrofolate reductase, thymidine kinase, and transferrin receptor genes. A 255-base-pair fragment of the 4F2HC gene which contains 154 base pairs of the 5' flanking sequence was able to efficiently promote expression of the bacterial chloramphenicol acetyltransferase gene in human Jurkat T cells, indicating that it contains promoter or enhancer (or both) sequences. Analyses of chromatin structure in resting and lectin-activated T cells revealed the presence of stable DNase I-hypersensitive sites within both the 5' flanking and intron 1 regions of the 4F2HC gene. Although the 4F2HC gene displayed many of the structural features characteristic of a constitutively expressed gene, lectin-mediated activation of resting peripheral blood T lymphocytes resulted in a dramatic increase in steady-state levels of 4F2HC mRNA.
Adaptive Strassen and ATLAS's DGEMM: a fast square-matrix multiply for modern high-performance systems (2005)

Strassen's algorithm has practical performance benefits for architectures with simple memory hierarchies, because it trades computationally expensive matrix multiplications (MM) with cheaper matrix additions (MA). However, it presents no advantages for high-performance architectures with deep memory hierarchies, because MAs exploit limited data reuse. We present an easy-to-use adaptive algorithm combining Strassen's recursion and high-tuned version of ATLAS MM. In fact, we introduce a last step in the ATLAS-installation process that determines whether Strassen's may achieve any speedup. We present a recursive algorithm achieving up to 30% speed-up versus ATLAS alone. We show experimental results for 14 different systems
Learning-based entity resolution with MapReduce (2011)

Entity resolution is a crucial step for data quality and data integration. Learning-based approaches show high effectiveness at the expense of poor efficiency. To reduce the typically high execution times, we investigate how learning-based entity resolution can be realized in a cloud infrastructure using MapReduce. We propose and evaluate two efficient MapReduce-based strategies for pair-wise similarity computation and classifier application on the Cartesian product of two input sources. Our evaluation is based on real-world datasets and shows the high efficiency and effectiveness of the proposed approaches.
Tunable Surfaces: Real‐Time Manipulation with Magnetically Tunable Structures (Adv. Mater. 37/2014) (2014)

A flexible uniform responsive microstructure (μFUR) array is reported by E. N. Wang and co-workers, on page 6442. The μFUR has continuous and extreme tilt angles via the application of a magnetic field and is used to dynamically manipulate liquid spreading directionality, control fluid drag, and tune optical transmittance over a large range. Cover art by Carly L. Sanker.
Current Treatment Practices and Prognostic Factors in Early-Stage Ovarian Cancer—An Analysis of the NOGGO/JAGO (2023)

This study helps to increase our understanding of early-stage OC treatment and prognosis. In addition to treating patients in compliance with current guidelines, the need for <i>BRCA</i> testing should also be considered for early-stage OC.
Fluid and electrolyte balance in elite male football (soccer) players training in a cool environment (2004)

There are few data in the published literature on sweat loss and drinking behaviour in athletes training in a cool environment. Sweat loss and fluid intake were measured in 17 first-team members of an elite soccer team training for 90 min in a cool (5 degrees C, 81% relative humidity) environment. Sweat loss was assessed from the change in body mass after correction for the volume of fluid consumed. Sweat electrolyte content was measured from absorbent patches applied at four skin sites. Mean (+/- s) sweat loss during training was 1.69+/-0.45 l (range 1.06-2.65 l). Mean fluid intake during training was 423+/-215 ml (44-951 ml). There was no apparent relationship between the amount of sweat lost and the volume of fluid consumed during training (r2 = 0.013, P = 0.665). Mean sweat sodium concentration was 42.5+/-13.0 mmol l(-1) and mean sweat potassium concentration was 4.2+/-1.0 mmol x l(-1). Total salt (NaCl) loss during training was 4.3+/-1.8 g. The sweat loss data are similar to those recorded in elite players undergoing a similar training session in warm environments, but the volume of fluid ingested is less.
Design of a dual-bandpass filter with dispersive coupling (2017)

In this paper, we intend to design of a wide band dualband filter with dispersive couplings for improved selectivity. The proposed approach consists to use this novel filter synthesis technique, taking advantage of the frequency variation of coupling values, for generating additional transmission zeroes. The dispersive coupling behavior is demonstrated and employed to design a four pole filter with three transmission zeros. The design is validated by a prototype and a six-pole dual-band bandpass filter based on the same concept is proposed for 5G millimeter-wave bands.
Haplotype-assisted accurate non-invasive fetal whole genome recovery through maternal plasma sequencing (2013)

Abstract Background The applications of massively parallel sequencing technology to fetal cell-free DNA (cff-DNA) have brought new insight to non-invasive prenatal diagnosis. However, most previous research based on maternal plasma sequencing has been restricted to fetal aneuploidies. To detect specific parentally inherited mutations, invasive approaches to obtain fetal DNA are the current standard in the clinic because of the experimental complexity and resource consumption of previously reported non-invasive approaches. Methods Here, we present a simple and effective non-invasive method for accurate fetal genome recovery-assisted with parental haplotypes. The parental haplotype were firstly inferred using a combination strategy of trio and unrelated individuals. Assisted with the parental haplotype, we then employed a hidden Markov model to non-invasively recover the fetal genome through maternal plasma sequencing. Results Using a sequence depth of approximately 44X against a an approximate 5.69% cff-DNA concentration, we non-invasively inferred fetal genotype and haplotype under different situations of parental heterozygosity. Our data show that 98.57%, 95.37%, and 98.45% of paternal autosome alleles, maternal autosome alleles, and maternal chromosome X in the fetal haplotypes, respectively, were recovered accurately. Additionally, we obtained efficient coverage or strong linkage of 96.65% of reported Mendelian-disorder genes and 98.90% of complex disease-associated markers. Conclusions Our method provides a useful strategy for non-invasive whole fetal genome recovery.