gebhart/patrepeval huggingface dataset:
Nucleotide sequence of theglpRgene encoding the repressor for the glycerol-3-phosphate regulon ofEscherichia coliK12 (1988)

Journal Article Nucleotide sequence of the glpR gene encoding the repressor for the glycerol-3-phosphate regulon of Escherichia coli K12 Get access Yong-Lark Choi, Yong-Lark Choi Laboratoiry of Biochemistry, Department of Agricultural Chemistry, Kyoto UniversityKyoto 606, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Shido Kawase, Shido Kawase Laboratoiry of Biochemistry, Department of Agricultural Chemistry, Kyoto UniversityKyoto 606, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Tohru Nishida, Tohru Nishida Laboratoiry of Biochemistry, Department of Agricultural Chemistry, Kyoto UniversityKyoto 606, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroshi Sakai, Hiroshi Sakai Laboratoiry of Biochemistry, Department of Agricultural Chemistry, Kyoto UniversityKyoto 606, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Tohru Komano, Tohru Komano Laboratoiry of Biochemistry, Department of Agricultural Chemistry, Kyoto UniversityKyoto 606, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Makoto Kawamukai, Makoto Kawamukai 1Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Shimane UniversityMatsue 690, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Ryutaro Utsumi, Ryutaro Utsumi 2Laboratory of Biochemistry, Department of Agricultural Chemistry, Kinki UniversityHigashiosaka, Osaka 577, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuji Kohara, Yuji Kohara +Department of Molecular Biology, School of Science, Nagoya UniversityNagoya 464, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Kiyotaka Akiyama Kiyotaka Akiyama +Department of Molecular Biology, School of Science, Nagoya UniversityNagoya 464, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 15, 11 August 1988, Page 7732, https://doi.org/10.1093/nar/16.15.7732 Published: 11 August 1988 Article history Accepted: 28 June 1988 Published: 11 August 1988
Potential for Targeting the Fibroblast Growth Factor Receptors in Breast Cancer (2010)

Breast cancer is the most common cancer of women, accounting yearly for approximately 30% of newly diagnosed cases and ranking second as a cause of death. Despite improvements in breast cancer detection and development of new therapeutic approaches, there are still tumors for which no targeted therapies are available. This review summarizes recent findings on the fibroblast growth factor receptors (FGFR) and the data supporting their role in breast cancer. We will describe the approaches being made to develop therapeutics targeting these receptors. Finally, to improve the chances for success with FGFR signal transduction inhibitors, strategies to choose appropriate breast cancer patients for treatment will be discussed.
[Long-term results of retropubic radical prostatectomy]. (2010)

Retropubic radical prostatectomy (RPPE) is the most aggressive method of treatment in patients with prostate cancer (PC), but maximally radical. The observations of men after RPPE have shown that 10.13% (40 patients) died: half of them (5.06%)--due to progress of PC, the rest because of coexisting diseases. The total, corrected and relapse-free 5 and 10 years survival was 90%, 95%, 65% and 84%, 91%, 55%. The quality of life of the men after RPPE was investigated at long-term periods of followup. RPPE is an effective method of treatment of PC patients. The most frequent complication of this intervention was erectile dysfunction and urinary incontinence which made the quality of life of such patients considerably worse. Postoperative dynamic follow-up of such patients is necessary for early detection of relapses and determination of indications for medicamentous and/or surgical treatments of the complications.
HR22C16: A Potent Small‐Molecule Probe for the Dynamics of Cell Division (2003)

A high-throughput, microscopy-based chemical-genetic screen identified HR22C16, which causes a monoastral mitotic block, as a small-molecule probe for cell division (see picture). By using a diastereoselective, traceless solid-phase synthesis and biological assays, a more potent HR22C16 analogue was then identified. A photocaging strategy for HR22C16 was also developed to allow fast temporal control over the function of the target protein Eg5. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51173_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis (2002)

Urokinase plasminogen activator (uPA) is an important regulator of fibrinolysis in synovial fluid. An increase of uPA activity and expression of its receptor have been reported in joints of patients with rheumatoid arthritis (RA). The aim of the present study was to assess the arthritogenic capacity of uPA and the mechanisms by which this effect is mediated. uPA was injected into the knee joints of healthy mice, and morphological signs of arthritis were assessed 4 days after the injection. The prerequisite of different leukocyte populations for the development of uPA-triggered arthritis was assessed by selective cell depletion. The inflammatory capacity of uPA was assessed in vitro. Finally, levels of uPA were measured in 67 paired blood and synovial fluid samples from RA patients. The synovial fluid from RA patients displayed higher levels of uPA compared with blood samples. Morphological signs of arthritis were found in 72% of uPA-injected joints compared with in only 18% of joints injected with PBS (P < 0.05). Synovitis was characterised by infiltration of CD4-Mac-1+ mononuclear cells, by the formation of pannus and by occasional cartilage destruction. The absence of monocytes and lymphocytes diminished the frequency of synovitis (P < 0.01), indicating an arthritogenic role of both these leukocyte populations. Synthetic uPA inhibitor downregulated the incidence of uPA-triggered arthritis by 50%. uPA induced arthritis, stimulating the release of proinflammatory cytokines IL-6, IL-1beta and tumour necrosis factor alpha. Accumulation of uPA locally in the joint cavity is a typical finding in erosive RA. uPA exerts potent arthritogenic properties and thus may be viewed as one of the essential mediators of joint inflammation.
Animal welfare and the 3Rs in European biomedical research (2011)

The new Directive 2010/63/EU to ensure harmonization of animal experimentation rules has potential to increase implementation of the 3Rs (reduce, refine, replace) and improve animal welfare across Europe.
Clay Catalysis: Stork's Alkylation and Acylation of Cyclohexanone Without Isolation of Enamine (1996)

Abstract Cyclohexanone and morpholine in the presence of KSF under azeotropic distillation gave 1-morpholinocyclohexene which is alkylated or acylated in situ without isolation of the enamine. The overall yield of these Stork's reactions are better or equivalent to those obtained by isolation of the enamine.
Kα X-ray Emission Spectroscopy on the Photosynthetic Oxygen-Evolving Complex Supports Manganese Oxidation and Water Binding in the S3 State (2018)

The unique manganese-calcium catalyst in photosystem II (PSII) is the natural paragon for efficient light-driven water oxidation to yield O<sub>2</sub>. The oxygen-evolving complex (OEC) in the dark-stable state (S<sub>1</sub>) comprises a Mn<sub>4</sub>CaO<sub>4</sub> core with five metal-bound water species. Binding and modification of the water molecules that are substrates of the water-oxidation reaction is mechanistically crucial but controversially debated. Two recent crystal structures of the OEC in its highest oxidation state (S<sub>3</sub>) show either a vacant Mn coordination site or a bound peroxide species. For purified PSII at room temperature, we collected Mn Kα X-ray emission spectra of the S<sub>0</sub>, S<sub>1</sub>, S<sub>2</sub>, and S<sub>3</sub> intermediates in the OEC cycle, which were analyzed by comparison to synthetic Mn compounds, spectral simulations, and OEC models from density functional theory. Our results contrast both crystallographic structures. They indicate Mn oxidation in three S-transitions and suggest additional water binding at a previously open Mn coordination site. These findings exclude Mn reduction and render peroxide formation in S<sub>3</sub> unlikely.
Management factors and clinical implications of glandular and squamous gastric disease in horses (2018)

The findings of our study further support the notion that EGGD should be considered as a distinct disease entity to ESGD. Exercising ≤4 days per week could reduce the risk of EGGD. Horses with EGGD are more likely to perform below expectation and, as such, EGGD might be performance limiting in some affected individuals. Stress minimization could reduce the risk of EGGD.
Inactivation of Phage MS2 by Iron-Aided Titanium Dioxide Photocatalysis (1994)

Near-UV photocatalytic disinfection was accomplished in aqueous titanium dioxide suspensions. A level of inactivation of phage MS2 of 90% increased to 99.9% after 2 muM ferrous sulfate was added. Hydroxyl radical oxidation, with Fenton reaction enhancement, is suspected to be primarily responsible for the viral degradation observed.
The small peptide-catalyzed direct asymmetric aldol reaction in water (2005)

Simple modular di- and tripeptides with a primary amine at the N-terminus catalyze the aqueous asymmetric aldol reaction between unmodified ketones and aldehydes to furnish the corresponding beta-hydroxy ketones with up to 86% ee in water and 99% ee in aqueous media.
Neural networks for vision and image processing (1992)

Visual adaptation to a negative, brightness-reversed world - some preliminary observations, Stuart Anstis prevailing lightness and hue and perceived texture segregation, Jacob Beck and William Goodwin perception - a biological perspective, V.S. Ramachandran the visual perception of 3-dimensional form, J. Farley Norman and James T. Todd a new approach to shape from shading, Pierre Breton, et al dynamic vision, Alex P. Pentland figure-ground separation of connected scenic figures - boundaries, filling-in, and opponent processing, Stephen Grossberg and Lonce Wyse toward a unified theory of spatiotemporal processing in the retina, Paolo Gaudiano neurodynamics of real-time image velocity extraction, David A. Fay and Allen M. Waxman why do parallel cortical systems exist for the perception of static form and moving form?, Stephen Grossberg neural dynamics of visual motion perception - local detection and global grouping, Stephen Grossberg and Ennio Mingolla neural circuits for visual attention in the primate brain, Robert Desimone attentive supervised learning and recognition by an adaptive resonance system, Gail A. Carpenter, et al synchronized oscillations for binding spatially distributed feature codes into coherent spatial patterns, Stephen Grossberg and David Somers a quotient space hough transform for space variant visual attention, Alan S. Rojer and Eric L. Schwartz optics and neural nets, David Casasent neural networks for image analysis, Robert Hecht-Neilsen.
Treatment of a Patient With Cleidocranial Dysplasia Using a Single‐Stage Implant Protocol (2016)

This patient report describes the treatment of a 45-year-old Caucasian woman with cleidocranial dysplasia who had significant dental problems that greatly affected her quality of life. The patient had orthodontic treatment in her earlier years along with surgical removal of supernumerary teeth. Using implants, the maxillary and mandibular arches were restored with fixed screw-retained prostheses. Eight and six implants were placed in the maxilla and mandible, respectively. Both arches were immediately loaded following the Teeth in a Day™ protocol using an all-acrylic resin provisional prosthesis. Five months later, definitive maxillary and mandibular prostheses were fabricated. The patient has been followed for a period of 5 years, and all postoperative evaluations have been uneventful.
Integration of EEMD and ICA for wind turbine gearbox diagnosis (2013)

ABSTRACT Gearbox failure becomes a major concern for reliability of wind turbine because of complex repair procedures, long downtime and high replacement costs. Prior studies showed that the majority of gearbox failures were initiated from bearing failures. Because of the low signal‐to‐noise ratio (mixture of bearing defect signals and gear meshing signals) and transient nature of bearing signals, it poses significant difficulty for bearing defect diagnosis in wind turbine gearbox at the incipient stage. To address it, this paper presents an effective fault component separation method that integrates ensemble empirical mode decomposition (EEMD; an adaptive signal decomposition method in time‐frequency domain) with independent component analysis (ICA; a blind source separation technique), without requiring a priori information on the rotating speeds or bandwidth. The method firstly decomposes one‐channel vibration measurements into a series of intrinsic mode functions as pseudo‐multi‐channel signals, by means of EEMD. ICA is performed on the intrinsic mode functions to separate bearing defect‐related signals from gear meshing signals. Envelope spectrum analysis is performed on the bearing defect‐related signals to identify bearing structural defects. The effectiveness of the developed method in separating bearing defect‐related signals from gear meshing signals for more effective fault diagnosis in bearings is evaluated and confirmed, numerically and experimentally. Copyright © 2013 John Wiley &amp; Sons, Ltd.
The effect of patient facemask usage on post-injection endophthalmitis among intravitreally injected patients in Ohio from 2019-2020 (2021)

Purpose : To evaluate the incidence of post-injection endophthalmitis in patients wearing facemasks. We hypothesize that the incidence of post-injection endophthalmitis in patients wearing facemasks would be significantly greater than patients who were not wearing facemasks. Methods : A retrospective cohort study was performed at a private retinal practice in Ohio. The practice management database was searched using CPT codes for endophthalmitis over two, six-month periods. The first cohort from 6/01/2019-12/31/2019, and the second, following universal facemask usage due to COVID 19, from 6/01/2020-12/31/2020. Patients who developed endophthalmitis post-intravitreal injection during the study period had their charts reviewed. Data collected included: age, sex, visual acuity, medication injected, administering physician, date of diagnosis, length of follow up, intervention, and cultured organism. Means of variables and chi-squared analyses were performed to determine statistical difference between non-masked and masked cohorts. Results : A total of 25029 intravitreal injections were performed in the first study period with 34019 injections in the second. Of those injections, endophthalmitis occurred in 8 and 12 patients respectively. Incidence of post-injection endophthalmitis in the 2019 was .00039 and .00041 in 2020 (p-value= 0.8289). The mean age of patients was 69 years in 2019 and in 68 years in 2020. Average length of follow up in 2019 was 472 days, and 74 days in 2020. Average change in visual acuity from diagnosis to last follow up was .707 in 2019 and .945 in 2020. In 2019 all six positive cultures grew coagulase negative staph, in 2020 the three positive cultures yielded Streptococcus mitis, gram positive cocci, and rare skin flora. Conclusions : We reject our hypothesis of, if patients were wearing masks during intravitreal injections, then there would be a significantly greater incidence of postinjection endophthalmitis. There was no significant association between wearing facemasks and post-injection endophthalmitis within our six-month study periods in 2019 and 2020. However, cultures between the two cohorts yielded different organisms, with one culture in 2020 presenting an organism typically found in oral flora.
Analysis of single switch delta-sigma modulated pulse space modulation PFC converter effectively using switching power device (2003)

With recent advances of semiconductor switching power devices, high frequency switching mode power converters are able to be realized. In these converters, the pulse width modulation (PWM) technique is widely used, but by using this control scheme, large peak noise spectra appear with odd interval of carrier frequency. Therefore, there are problems to keep the regulation of EMI noise. By the way, to improve input power factor of AC source line, power factor correction (PFC) converters are widely used. And the hysteresis control scheme is usually used for these PFC converters. But in this control scheme, lower and upper limit of switching frequency can not be determined. In this paper, the authors propose a novel delta-sigma modulated PFC converter utilizing pulse space modulation scheme. The authors improve delta-sigma modulation scheme and conventional PWM control scheme to reduce current rating of switching devices. And the authors implemented evaluation of comparing performance of proposed and conventional control scheme. The authors confirmed that proposed system can improve power factor and can reduce input current harmonics and noise level by exhibiting spread spectrum nature. And the proposed scheme extinguishes noise peak spectra. Furthermore, by using current limiting control scheme, the proposed scheme can reduce current rating of switching power devices in spite of simple configuration circuit.
An Investigation on Speech Perception Under Effects of Coarticulation (2012)

In this paper, we investigated the speech perception under effects of coarticulation within syllables, including estimating the nuclei and coarticulated transition intervals of phonemes, and investigating the perception of nuclei and coarticulated transition intervals of phonemes within syllables. To complete these objectives, we firstly proposed the folded spectral transition measure to estimate the boundary points between the nuclei interval and coarticulated transition intervals. Then, we conducted experiments to investigate the syllable identification and syllable quality evaluation under effects of coarticulation. The experimental results show that human can identify the syllables with the retaining intervals equal or wider the coarticulated transition intervals. Besides, the experimental results show that the nuclei intervals are still important for speech quality perception; the quality of truncated syllables retaining the two phoneme nucleus and coarticulated transition interval between the two phonemes within syllable is equivalent with the quality of original two-phoneme syllables.
Chemoselective ligation in glycochemistry (2004)

This feature article describes chemoselective techniques for the assembly of neoglycopeptides and oligosaccharide mimics. Chemoselective ligation, allowing the use of aqueous environments and non-protected substrates, provides rapid access to complex glycoconjugates. The role of these molecules in recognition, signal transduction pathways and other events of fundamental biomedical significance is an object of study in the emerging field of chemical glycomics.
High-Speed guided-wave optical components (1981)

An important property of the light wave is its potential large bandwidth or high speed. With the progress of single-mode fiber technology much attention is being paid to this property. Recently several high-speed guided-wave modulator/switches have been demonstrated with a bandwidth of several gigahertz.1-3 in this paper, design problems with high-speed optical guided-wave components are discussed.
ChemInform Abstract: Alkylisobenzofurans from Phthalides. Inter‐ and Intramolecular Diels‐Alder Reactions. (1990)

Abstract Reaction of the phthalides (I) with the 1,1‐dibromoalkanes (II) in the presence of titanium tetrachloride and zinc dust yields the alkylidene phthalans (III).
DELIVERing Progress in Heart Failure with Preserved Ejection Fraction (2022)

More than 6 million adults in the United States have heart failure, accounting for at least 800,000 hospitalizations annually.1 More than half of these persons have heart failure with a preserved left ventricular ejection fraction.1 As the population ages, the overall prevalence of patients with heart failure and a preserved ejection fraction is increasing.1,2 Heart failure with a preserved ejection fraction is associated with substantial functional and quality-of-life impairments that are at least equivalent to those of patients with heart failure and a reduced ejection fraction.2 One-year mortality among patients with heart failure and a preserved ejection fraction is between . . .
LTE-advanced Carrier Aggregation solution on heterogeneous and Hardware accelerated system (2016)

Demand for high data-rate mobile broadband is on the rise with the proliferation of over-the-top (OTT) applications. Carrier Aggregation (CA) is the fourth generation LTE-A (Long Term Evolution - Advanced) wireless network technology defined to meet this demand. This paper provides in-depth description of the engineering methods to develop LTE-A Carrier Aggregation solution by enhancing non-CA LTE wireless system. It summarizes the need of CA in today's telecommunications ecosystem, background of the system platform, system design and key challenges in implementing CA solution on an industry leading System-on-Chip (SoC). The paper elaborates software solution designs to overcome the platform hardware challenges. The proposed solution is verified with 10+10 MHz Carrier Aggregation and end-to-end system performance results are highlighted.
Is pacifier use a risk factor for acute otitis media? A dynamic cohort study (2008)

Pacifier use appears to be a risk factor for recurrent AOM. Parents should be informed about the possible negative effects of using a pacifier once their child has been diagnosed with AOM to avoid recurrent episodes.