gebhart/patrepeval huggingface dataset:
Creation of virtual auditory spaces (2002)

High-quality virtual audio scene rendering is a must for emerging virtual/augmented reality applications and for perceptual user interfaces. We describe algorithms for creation of virtual auditory spaces using measured and non-individualized HRTFs and head tracking. Details of algorithms for HRTF interpolation, room impulse response creation, and audio scene presentation are presented. Tests show that individuals externalize well, and find our interface natural. The system runs in real time with latency of less than 30 ms on an office PC without specialized DSP.
Incredible journey: how do developmental signals travel through tissue? (2004)

How developmental signaling proteins traverse tissue during animal development, through or around tightly packed cells, remains an incompletely resolved mystery. Signaling protein movement is regulated to create gradients, control amounts, impose barriers, or provide direction. Signaling can be controlled by the rate of signal production, modification, active transport, trapping along the path, or by the properties of the receptor apparatus. Signals may move by diffusion outside cells, attached to migrating cells, attached to carrier molecules, through cells by transcytosis, along cell extensions, or in released membrane packets. Recent findings about the movement of Hedgehog, Wingless (Wnt), and TGF-beta signaling proteins have helped to clarify the molecular mechanisms used to ensure that developmental signals carry only good news.
SPADS: Publisher Anonymization for DHT Storage (2010)

Many distributed applications, such as collaborative Web mapping, collaborative feedback and ranking, or bug reporting systems, rely on the aggregation of privacy-sensitive information gathered from human users. This information is typically aggregated at servers and later used as the basis for some collaborative service. Expecting that clients trust that the user-centric information will not be used for malevolent purposes is not realistic in a fully distributed setting where nodes are not under the control of a single administrative domain. Moreover, most of the time the origin of the data is of small importance when computing the aggregation onto which these services are based. Trust problems can be evinced by ensuring that the identity of the user is dropped before the data can actually be used, a process called publisher anonymization. Such a property shall be guaranteed even if a set of servers is colluding to spy on some user. This also requires that malevolent users cannot harm the service by sending any number of items without being traceable due to publisher anonymization. Rate limitation and decoupled authentication are the two mechanisms that ensure that these cheating users have a limited impact on the system. This paper presents SPADS, a system that interfaces to any DHT and supports the three objectives of publisher anonymization, rate limitation and decoupled authentication. The evaluation of a deployed prototype on a cluster assesses its performance and small footprint.
S1360101 Magnetic Pattern Formation of Magnetic Material by EDM (2015)

Permanent magnets are used in industrial devices. In general, a permanent magnet is made using a powder metallurgical process and magnetized in the final process. The shape of the magnet depends on the mold. When a special shape is required it is created by machining before the magnetization. It is difficult to machine after magnetization because the magnets are brittle and the magnetic force affects the machining tool. Electrical discharge machining (EDM) is a non-contact thermal machining method. Therefore, EDM can easily machine a magnet constructed from electrical conducting material. However, temperatures can exceed the melting point at the discharge point of EDM. A permanent magnet has a Curie point and temperature-dependence. Past studies have concluded that magnetic flux density of permanent magnets changes when machining conditions change. This study investigated influences on magnetic flux density when the magnetic field changes during EDM of a permanent magnet. In particular, the magnetic field generated by the magnet changed by pressing a plate with high permeability on the surface of the permanent magnet. Internal temperature and surface magnetic flux density measurements on an opposite surface during machining working were performed to examine influences on the magnet when the magnetic field changed.
Visualizing network data for intrusion detection (2005)

As the trend of successful network attacks continue to rise, better forms of intrusion detection and prevention are needed. This paper addresses network traffic visualization techniques that aid an administrator in recognizing attacks in real time. Our approach improves upon current techniques that lack effectiveness due to an overemphasis on flow, nodes, or assumed familiarity with the attack tool, causing either late reaction or missed detection. A port-based overview of network activity produces a improved representation for detecting and responding to malicious activity. We have found that presenting an overview using stacked histograms of aggregate port activity, combined with the ability to drill-down for finer details allows small, yet important details to be noticed and investigated without being obscured by large, usual traffic. Due to the amount of traffic as well as the range of possible port numbers and IP addresses, scaling techniques are necessary to help provide this overview. We provide graphs with examples of forensic findings. Finally, we describe our future plans for using live traffic in addition to our forensic visualization techniques.
Photovoltaic and structural properties of a-Si:H thin films Quarterly technical progress report No. 2, September 1-November 30, 1980 (1980)

The highlights during the second quarter of the research program on rf-sputtered a-Si:H films are: (1) completion of a systematic series of tests on which both the partial pressures of Ar and H/sub 2/ were varied over wide ranges; (2) the important sputtering parameters of real film temperature and floating film potential during deposition were measured; (3) comparison of SIMS and nuclear reaction analysis for H-depth-profiling of a-Si:H; and (4) demonstration that spectroscopic ellipsometry is a rapid and precise method for characterizing the optical properties of a-Si:H films. (LEW)
Efficacy of selective transarterial chemoembolization for recurred liver metastases from intracranial meningioma: A case report (2023)

Extracranial metastases from intracranial meningioma involve multiple organs with repeatedly recurrence. Due to the rarity of these metastases, management remains to be established, especially in cases that are not amenable to surgery, such as postsurgical relapse and multiple metastases. We present the case of a right tentorial meningioma with multiple extracranial metastases, including postsurgical recurrent liver metastases. The intracranial meningioma was surgically resected when the patient was 53 years of age. The patient was 66 years of age when the hepatic lesion was first revealed, for which an extended right posterior sectionectomy was performed. Histopathology demonstrated a metastatic meningioma. Twelve months after liver resection, multiple local recurrences in the right hepatic lobe were revealed. Because additional surgical resection would put the patient at risk of declining residual liver function, we performed selective transarterial chemoembolization, resulting in a reduction in size and good control without relapse. Selective transarterial chemoembolization for incurable liver metastatic meningiomas could be valuable in palliating patients unsuitable for surgery.
The Effect of Mutations in α-Tropomyosin (E40K and E54K) That Cause Familial Dilated Cardiomyopathy on the Regulatory Mechanism of Cardiac Muscle Thin Filaments (2007)

E40K and E54K mutations in alpha-tropomyosin cause inherited dilated cardiomyopathy. Previously we showed, using Ala-Ser alpha-tropomyosin (AS-alpha-Tm) expressed in Escherichia coli, that both mutations decrease Ca(2+) sensitivity. E40K also reduces V(max) of actin-Tm-activated S-1 ATPase by 18%. We investigated cooperative allosteric regulation by native Tm, AS-alpha-Tm, and the two dilated cardiomyopathy-causing mutants. AS-alpha-Tm has a lower cooperative unit size (6.5) than native alpha-tropomyosin (10.0). The E40K mutation reduced the size of the cooperative unit to 3.7, whereas E54K increased it to 8.0. For the equilibrium between On and Off states, the K(T) value was the same for all actin-Tm species; however, the K(T) value of actin-Tm-troponin at pCa 5 was 50% less for AS-alpha-Tm E40K than for AS-alpha-Tm and AS-alpha-Tm E54K. K(b), the "closed" to "blocked" equilibrium constant, was the same for all tropomyosin species. The E40K mutation reduced the affinity of tropomyosin for actin by 1.74-fold, but only when in the On state (in the presence of S-1). In contrast the E54K mutation reduced affinity by 3.5-fold only in the Off state. Differential scanning calorimetry measurements of AS-alpha-Tm showed that domain 3, assigned to the N terminus of tropomyosin, was strongly destabilized by both mutations. Additionally with AS-alpha-Tm E54K, we observed a unique new domain at 55 degrees C accounting for 25% of enthalpy indicating stabilization of part of the tropomyosin. The disease-causing mechanism of the E40K mutation may be accounted for by destabilization of the On state of the thin filaments; however, the E54K mutation has a more complex effect on tropomyosin structure and function.
Population Dynamics of Corn Earworm Larvae (Lepidoptera: Noctuidae) on Corn in the Lower Rio Grande Valley (1990)

The development of corn earworm, Heliothis zea, populations on corn was investigated in the Lower Rio Grande Valley of Texas and Tamaulipas, Mexico, during 1985 and 1986. Initial infestations by small larvae of 42.8 and 19.8% on whorl stage corn occurred during the weeks ending on day 102 (12 April) of 1985 and day 95 (5 April) of 1986, respectively. Initial trap peaks of 108 males/trap (1985) and 61 males/trap (1986) occurred from 4 d before to 3 d after the initial estimated oviposition peaks. Adults from larvae developing on whorl stage corn produced the infestation on fruiting corn during the weeks ending on days 130–137 and resulted in the largest trap peak of the year (132 males/trap in 1985 and 289 males/trap in 1986). Midpeak of trap capture occurred 9–12 d after the oviposition peak on fruiting corn. Adult emergence in fruiting corn occurred between days 150 and 182 and averaged 3.0 and 0.80/m2 respectively for 1985 and 1986. The lack of a major trap peak associated with this emergence indicates that a major portion of these adults migrated from the area before mating.
Supplementary Figure 2 from Targeting the Microtubular Network as a New Antimyeloma Strategy (2023)

&lt;p&gt;PDF file - 199K, Nocodazole induces microtubular network disarray and morphologic elongation in multiple myeloma cells.&lt;/p&gt;
Regulation of Cell Volume and Renal Injury (1972)

Conference Abstract| May 01 1972 Regulation of Cell Volume and Renal Injury Alexander Leaf; Alexander Leaf 1Departments of Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston Search for other works by this author on: This Site PubMed Google Scholar Jorge Flores; Jorge Flores 1Departments of Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston Search for other works by this author on: This Site PubMed Google Scholar Donald DiBona Donald DiBona 1Departments of Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (1972) 42 (5): 25P–26P. https://doi.org/10.1042/cs042025Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Alexander Leaf, Jorge Flores, Donald DiBona; Regulation of Cell Volume and Renal Injury. Clin Sci 1 May 1972; 42 (5): 25P–26P. doi: https://doi.org/10.1042/cs042025Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1972 The Biochemical Society and the Medical Research Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.
Amniotic fluid derived mesenchymal stem cells for perinatal therapeutic applications (2012)

status: Published
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy (2013)

Proliferative vitreoretinopathy (PVR) is a severe, vision-threatening disorder characterized by the fibrous membrane formation that leads to tractional retinal detachment. There has been no effective therapeutic approach other than vitreoretinal surgery. In this study, DNA microarray analysis of the fibrous membranes revealed significant up-regulation of periostin. We also found increased periostin expression in the vitreous and retinal pigment epithelial (RPE) cells from fibrous membranes of PVR patients. In vitro, periostin increased proliferation, adhesion, migration, and collagen production in RPE cells through integrin αV-mediated FAK and AKT phosphorylation. Periostin blockade suppressed migration and adhesion induced by TGFβ2 and PVR vitreous. In vivo, periostin inhibition had the inhibitory effect on progression of experimental PVR in rabbit eyes without affecting the viability of retinal cells. These results identified periostin as a pivotal molecule for fibrous membrane formation as well as a promising therapeutic target for PVR.
Big Fish, Little Fish, Critical Infrastructure: An Analysis of Phineas\n Fisher and the 'Hacktivist' Threat to Critical Infrastructure (2020)

The hacktivist threat actor is listed in many risk decision documents. Yet\ntheir tactics and techniques often remain a mystery. We create a MITRE ATT&amp;CK\n(ATT&amp;CK) model of a well known hacktivist who goes under the pseudonym of\nPhineas Fisher, and map that threat to critical infrastructure. The analysis is\nderived from hacker manifestos, journalist reporting, and official government\ndocumentation. This analysis fills a gap in current threat models, to better\ndefine what skills and methods a determined hacker might employ. This paper\nalso identifies seven essential mitigations which can be deployed by critical\ninfrastructure operations and asset owners, to prevent such intrusions by\nhacktivists. We are in the process of contributing this threat actor into the\nATT&amp;CK knowledge base.\n
Carbohydrate‐Based Molecules for Molecular Imaging in Nuclear Medicine (Eur. J. Org. Chem. 8/2013) (2013)

The cover picture shows a view of Portugal and the Azores islands with the logos of the public universities where Organic Chemistry is lectured, whose scientists and students participated in the 6th Spanish–Portuguese–Japanese Organic Chemistry Symposium (6th SPJ–OCS). Two magnifying glasses highlight Lisbon and the FCUL (Faculty of Sciences, University of Lisbon), where the 6th SPJ–OCS took place. The meeting was dedicated to the centenary of the Portuguese Chemical Society (Sociedade Portuguesa de Química, SPQ), the logo of which is also shown. The cover picture was authored by G. Ribeiro Morais (Campus Tecnologico e Nuclear, Instituto Superior Técnico, Sacavém, Portugal). Fátima Marques is thanked for technical assistance. Prof. Amélia Pilar Rauter is thanked for useful suggestions. For more on the SPJ–OCS and the SPQ see the Editorial and Society Spotlight on p. 1384 ff. The cover picture shows a view of Portugal and the Azores islands with the logos of the public universities where Organic Chemistry is lectured, whose scientists and students participated in the 6th Spanish–Portuguese–Japanese Organic Chemistry Symposium (6th SPJ–OCS). Two magnifying glasses highlight Lisbon and the FCUL (Faculty of Sciences, University of Lisbon), where the 6th SPJ–OCS took place. The meeting was dedicated to the centenary of the Portuguese Chemical Society (Sociedade Portuguesa de Química, SPQ), the logo of which is also shown. The cover picture was authored by G. Ribeiro Morais (Campus Tecnologico e Nuclear, Instituto Superior Técnico, Sacavém, Portugal). Fátima Marques is thanked for technical assistance. Prof. Amélia Pilar Rauter is thanked for useful suggestions. For more on the SPJ–OCS and the SPQ see the Editorial and Society Spotlight on p. 1384 ff.
Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons (2018)

While the exact role of β1 subunit-containing GABA-A receptors (GABARs) in brain function is not well understood, altered expression of the β1 subunit gene (<i>GABRB1</i>) is associated with neurological and neuropsychiatric disorders. In particular, down-regulation of β1 subunit levels is observed in brains of patients with epilepsy, autism, bipolar disorder and schizophrenia. A pathophysiological feature of these disease states is imbalance in energy metabolism and mitochondrial dysfunction. The transcription factor, nuclear respiratory factor 1 (NRF-1), has been shown to be a key mediator of genes involved in oxidative phosphorylation and mitochondrial biogenesis. Using a variety of molecular approaches (including mobility shift, promoter/reporter assays, and overexpression of dominant negative NRF-1), we now report that NRF-1 regulates transcription of <i>GABRB1</i> and that its core promoter contains a conserved canonical NRF-1 element responsible for sequence specific binding and transcriptional activation. Our identification of <i>GABRB1</i> as a new target for NRF-1 in neurons suggests that genes coding for inhibitory neurotransmission may be coupled to cellular metabolism. This is especially meaningful as binding of NRF-1 to its element is sensitive to the kind of epigenetic changes that occur in multiple disorders associated with altered brain inhibition.
Broadband Printed-Circuit Yagi Array (2009)

Printed circuit board (PCB) antenna with useful bandwidth covering from 2.45 GHz to 3.80 GHz is suitable for WiMax, WLAN, and Bluetooth wireless communications applications. We present a low profile, seven elements Yagi array antenna etched on PCB of dielectric constant 4.2 achieving 43% bandwidth with return loss better than -10 dB, and directivity from 8.2 dBi to 11.1 dBi. Swept frequency return loss, impedance and radiation patterns of this antenna have been simulated and measured: The congruence between the simulated and measured results is satisfactory. In addition, current distribution on this broadband Yagi is also investigated.
Transmission properties of spark preionization radiation in rare-gas halide laser gas mixes (1995)

A charge collection apparatus was used to measure photocharge yields and transmission properties of light emitted from a spark preionizer discharge through various rare-gas halide laser gas mixes as well as through their component gas mixes. The data indicates that for HCl partial pressure (p) and photon path length (d) pd products /spl ges/100 Torr-cm, a narrow transmission window (114-124 nm) for preionization of XeCl and KrCl lasers occurs. In contrast, fluorine based rare-gas halide laser gas mixes were largely transparent over a critical 100-150 nm spectral window responsible for preionization. The role of gaseous impurities, two photon ionization processes, the photoelectric effect, passivation and air contamination on the photocharge signal and light transmission are described.
Temporal alterations in protein signaling cascades during recovery from muscle atrophy (2003)

Currently, the repertoire of cellular and molecular pathways that control skeletal muscle atrophy and hypertrophy are not well defined. It is possible that intracellular regulatory signaling pathways are active at different times during the muscle hypertrophy process. The hypothesis of the given experiments was that cellular signals related to protein translation would be active at early time points of skeletal muscle regrowth, whereas transcriptional signals would be active at later time points of skeletal muscle regrowth. The phosphorylation status of p38 MAPK and JNK increased at the end of limb immobilization but returned to control values at recovery day 3. Transient increases in phosphorylation and in protein concentration occurred during recovery of soleus muscle mass. Phosphorylation of Akt, p70S6k, and signal transducer and activator of transcription 3 (STAT3) peaked on recovery day 3 compared with day 0. Glycogen synthase kinase (GSK)-3beta phosphorylation was increased on the sixth and fifteenth recovery day. In addition, transient peaks in seven protein concentrations occurred at different times of recovery: STAT3, calcineurin A (CaNA), CaNB, and beta4E-BP1 protein concentrations peaked on the third recovery day; p70S6k, STAT3, Akt, and GSK3-beta peaked on the sixth recovery day; and GSK3-beta peaked on the fifteenth recovery day. The apexes of STAT3 and GSK3-beta protein concentrations remained elevated for two recovery time points. Thus the time course of increase in molecules of signaling pathways differed as the young rat soleus muscle regrew from an atrophied state.
Experimental and theoretical characterization of miniature coplanar waveguide shunt stubs patterned on the centre conductor (1999)

Several new designs are presented for coplanar waveguide (CPW) open- and short-ended shunt stubs patterned on the centre conductor. Unlike conventional stubs which are patterned on the ground plane, the new designs are more compact and less radiative. They also provide more flexibility to the design of CPW circuits. The performance of the new stubs is verified by experiment and simulation and is found to be very satisfactory over the large frequency band 0–50GHz. Experimental results obtained for a conventional and new stub show that the new stub is less radiative.
Low-Cost Teleconference System (1985)

Proposed video teleconferencing system displays drawings, photographs, and text for conferees. Although new system, called TELEDEMO, does not present live scenes from conference locations, it cost far less than conventional teleconference services. Widely scattered participants communiate by voice, graphics, and images over telephone lines.
A watermark sharing scheme to halftone images with genetic algorithms (2004)

We propose a watermark sharing scheme to binary halftone images, which is extended from an image halftoning scheme using genetic algorithms (GAs). In addition to the conventional evaluation functions on gray-level precision and appropriate contrast near edges, we design and introduce an evaluation function on watermark appearance to the scheme and generate multiple binary halftone images shared in a watermark image through the solution search of the GA. Simulation results have shown that we can share a watermark to generate a halftone image in keeping a high image quality, and clearly decode the embedded watermark by overlapping these images optically.