gebhart/patrepeval huggingface dataset:
Analysis of Patients Visiting an Oriental Hospital with Idiopathic Chronic Fatigue or Chronic Fatigue Syndrome (2013)

Objectives: Medically unexplained fatigue includes chronic fatigue syndrome (CFS) and idiopathic chronic fatigue (ICF). These disorders quite impair quality of life while no effective therapies exist. Therefore, patients with CFS or ICF frequently choose treatments based on traditional Korean medicine. The study aimed to analyze characteristic of patients visiting an Oriental clinic with CFS or ICF. Methods: Patients who met criteria for CFS or ICF were enrolled in this study, from March 2011 to Jun 2013. Clinical information focused on symptom differentiation and Sasang constitution was analyzed. Pearson's chi-square test was used to compare the frequency among sub-groups. Results: In total, 77 patients (49 male and 28 female) were diagnosed with CFS (17 male and 13 female) or ICF (32 male and 15 female). The symptom differentiation was 37.7%, 26.0%, 13.0%, and 23.3% for "Qi deficiency of both spleen and lung ( )", "Yin deficiency of both liver and kidney ( )", "Blood deficiency of both heart and spleen (
Volatile Rare Earth Chelates of β-Diketones (1967)

A number of volatile rare earth chelates containing the ligands, 1,1,1,2,2,3,3-heptafluoro-7,7-dimethyl-4,6-octanedione, [H(fod)], and 2,2,6,6-tetramethyl-3,5-heptanedione, [H(thd)] have been synthesized and investigated. The fod complexes are more volatile than other known compounds of the lanthanide elements. The fod complex of Sc(III) and the lanthanide thd compounds are anhydrous. The fod chelates of Y(III) and the lanthanides are isolated as hydrates but can easily be dehydrated in vacuo over P4O10. Gas chromatographic and thermogravimetric data reveal that the volatilities of the complexes increase as the ionic radii of the metal ions become smaller.
An inverse method for the processing of synthetic aperture radar data (1987)

An inverse method for the processing of synthetic aperture radar signals is presented. The method is independent of the relative bandwidth of the radar signal and should thus work when, for instance, the frequency of the emitted radiation is of the same order as the bandwidth, i.e. in low frequency, high resolution applications. It is shown that the obtained relations reduce to the correlation integrals of conventional SAR image processing in the case that the relative bandwidth of the signal is small. Range attenuation and antenna illumination effects may be fully compensated for.
Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation (2017)

Pulsatile actomyosin contractility, important in tissue morphogenesis, has been studied mainly in apical but less in basal domains. Basal myosin oscillation underlying egg chamber elongation is regulated by both cell-matrix and cell-cell adhesions. However, the mechanism by which these two adhesions govern basal myosin oscillation and tissue elongation is unknown. Here we demonstrate that cell-matrix adhesion positively regulates basal junctional Rho1 activity and medio-basal ROCK and myosin activities, thus strongly controlling tissue elongation. Differently, cell-cell adhesion governs basal myosin oscillation through controlling medio-basal distributions of both ROCK and myosin signals, which are related to the spatial limitations of cell-matrix adhesion and stress fibres. Contrary to cell-matrix adhesion, cell-cell adhesion weakly affects tissue elongation. In vivo optogenetic protein inhibition spatiotemporally confirms the different effects of these two adhesions on basal myosin oscillation. This study highlights the activity and distribution controls of basal myosin contractility mediated by cell-matrix and cell-cell adhesions, respectively, during tissue morphogenesis.
A comparison of Bygholm feed sieve to standard particle-size analysis techniques (2005)

Three experiments were conducted to evaluate the Bygholm Feed Sieve particle size tester. The Bygholm Feed Sieve is an 11 inch Ã— 2.25 inch Ã— 4.25 inch plastic box divided into four compartments by three different screen sizes (3,000-, 2,000-, and 1,000-micron mesh). In Experiment 1, particle size was determined for 20 ground corn samples with a Ro-Tap 13-sieve stack (53- to 3,350-micron Tyler mesh screens).The particle sizes ranged from 543 to 1,741 microns. Samples were analyzed for particle size with the standard Bygholm Feed Sieve, operated according to the manufacturerâ€™s directions. In Experiment 2, two rubber balls were placed on the 2,000 micron screen and one ball was placed on the 1,000 micron screen in the Bygholm Feed Sieve to aid in moving particles through the screens. Samples were then analyzed for particle size, according to the manufacturerâ€™s directions. In Experiment 3, 24 additional samples with particle sizes ranging from 604 to 1,305 microns were analyzed to determine the accuracy of the regression equation created by Experiment 1. After initial analysis indicated that the equation didnâ€™t accurately predict particle size of samples with a large particle size, an additional 11 samples with particle sizes ranging from 1,054 to 1,741 microns were analyzed. After this analysis, all samples from Experiments 1 and 3 were used to develop a new set of regression equations to calculate the particle size of samples over a wider micron range. The Bygholm Feed Sieve more accurately predicted the particle size of samples when rubber balls were not present within the system (RÂ² = 0.88 versus 0.82). The regression equation created by Experiment 1 predicted 90% of the samples to be within 100 microns of the actual particle size when the samples were less than 1,000 microns. When samples are coarser than 1,000 microns, however, the regression equation created by Experiment 3 should be used; it predicts 85% of the samples to be within 100 microns of the actual particle size when the samples were larger than 1,000 microns and 98% of all samples to be within 150 microns of the actual particle size.; Swine Day, 2005, Kansas State University, Manhattan, KS, 2005
Giant and ultrafast nonlinearity with ENZ Photonics (2021)

Nonlinearity provides a key functionality for a plurality of devices, effects, and systems. In this talk I show that both all-optical and electro-optical nonlinearity can be strongly enhanced at the slow-light effect epsilon-near-zero (ENZ). I share our recent experimental demonstrations including (a) temporally tailoring ENZ nonlinearity (Optics Letters 2020), (b) spectrally 400nm broadband ENZ enhancement, (b) GHz-fast yet micrometer-compact electro-optic modulator within a MZI-Silicon-ITO hybrid platform (OPTICA 2020, Scientific Reports 2021), and (c) Kramers-Kronig-enhanced electro-absorption modulator (NANOPHOTONICS 2019). Together, these technologies show that monolithic integration of TCO into PICs provides functionality beyond Silicon photonics with application in datacom, sensing, and neuromorphic computing.
Alias-free voxelization of geometric objects (1999)

Introduces a new concept for alias-free voxelization of geometric objects based on a voxelization model (V-model). The V-model of an object is its representation in 3D continuous space by a trivariate density function. This function is sampled during the voxelization and the resulting values are stored in a volume buffer. This concept enables us to study general issues of sampling and rendering separately from object-specific design issues. It provides us with a possibility to design such V-models, which are correct from the point of view of both the sampling and rendering, thus leading to both alias-free volumetric representation and alias-free rendered images. We performed numerous experiments with different combinations of V-models and reconstruction techniques. We have shown that the V-model with a Gaussian surface density profile combined with tricubic interpolation and Gabor derivative reconstruction outperforms the previously published technique with a linear density profile. This enables higher fidelity of images rendered from volume data due to increased sharpness of edges and thinner surface patches.
Association of genetic variations within the PD-L2 immune checkpoint gene with outcome in stage II and III colon cancer. (2018)

626 Background: Immune checkpoints can either inhibit or stimulate T-cell responses and therefore play a key role in maintaining an equilibrium between self tolerance and autoimmunity. Targeting immune checkpoint molecules can result in increased antitumor immunity by stimulation of the immune system. We hypothesize, that variations in genes encoding for both inhibitory or stimulatory immune checkpoint proteins may predict outcome in stage II and III colon cancer patients. Methods: The impact of 6 functional single nucleotide polymorphisms (SNPs) within the PD1, PD-L1, PD-L2, TIM3, OX40 and CD27 genes on time to recurrence was evaluated in 201 patients with stage II and III colon cancer. Genomic DNA was extracted from formalin-fixed paraffin embedded tissue and the SNPs were analyzed by PCR-based direct sequencing. Results: Baseline characteristics were as follows: female/male ratio = 42.8% / 57.2%; median age = 70y (19-91); median follow-up = 43months. The PD-L2 rs16923189 SNP showed significant association with recurrence rate. Patients with a G/G genotype had a higher 3-years recurrence rate compared to those harboring any A allele (41% vs 19%) in both univariate (HR 2.68, 95% Confidence interval (CI) 1.28-5.61, p = 0.006) and multivariate analyses (HR 3.13, 95% CI 1.42-6.28, p = 0.003). The high recurrence rate was most evident among patients with stage III and left-sided tumors carrying the G/G genotype (53% vs 24% and 65% vs 18%) in both univariate (HR 2.87, 95% CI 1.24-6.66, p = 0.009 and HR 5.28, 95% CI 2.24-12.44, p &lt; 0.0001) and multivariate analyses (HR 4.32, 95% CI 1.76-9.91, p = 0.001 and HR 5.20, 95% CI 2.02-12.75, p = 0.001). Conclusions: Our results provide the first evidence, that polymorphisms within the PD-L2 gene might serve as prognostic markers in patients with stage II and III colon cancer. Interestingly, the prognostic effect is most significant among patients with stage III and left-sided colon cancers. Targeting PD-L2 might be a promising approach to further optimize treatment options and to improve outcome of colon cancer patients in the adjuvant setting.
Signaling System 7 (SS7) Message Transfer Part 2 (MTP2) - User Adaptation Layer (2002)

This document defines a protocol for the backhauling of Signaling System 7 Message Transfer Part 2 (SS7 MTP2) User signalling messages over IP using the Stream Control Transmission Protocol (SCTP).This protocol would be used between a Signalling Gateway (SG) and Media Gateway Controller (MGC).It is assumed that the SG receives SS7 signalling over a standard SS7 interface using the SS7 Message Transfer Part (MTP) to provide transport.The Signalling Gateway would act as a Signalling Link Terminal.
Perfect control of reflection and refraction using spatially dispersive metasurfaces (2016)

Nonuniform metasurfaces (electrically thin composite layers) can be used for shaping refracted and reflected electromagnetic waves. However, known design approaches based on the generalized refraction and reflection laws do not allow realization of perfectly performing devices: there are always some parasitic reflections into undesired directions. In this paper we introduce and discuss a general approach to the synthesis of metasurfaces for full control of transmitted and reflected plane waves and show that perfect performance can be realized. The method is based on the use of an equivalent impedance matrix model which connects the tangential field components at the two sides on the metasurface. With this approach we are able to understand what physical properties of the metasurface are needed in order to perfectly realize the desired response. Furthermore, we determine the required polarizabilities of the metasurface unit cells and discuss suitable cell structures. It appears that only spatially dispersive metasurfaces allow realization of perfect refraction and reflection of incident plane waves into arbitrary directions. In particular, ideal refraction is possible only if the metasurface is bianisotropic (weak spatial dispersion), and ideal reflection without polarization transformation requires spatial dispersion with a specific, strongly nonlocal response to the fields.
Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker (2021)

Background and Purpose: Many pain-triggering nociceptor neurons express TRPV1 or TRPA1, cation-selective channels with large pores that enable permeation of QX-314, a cationic analogue of lidocaine. Co-application of QX-314 with TRPV1 or TRPA1 activators can silence nociceptors. We now describe BW-031, a novel more potent cationic sodium channel inhibitor, test whether its application alone can inhibit the pain associated with tissue inflammation, and whether this strategy can also inhibit cough. Experimental Approach: We characterized BW-031 inhibition of sodium channels and tested BW-031 in three models of inflammatory pain: rat paw inflammation produced by Complete Freund’s Adjuvant injection or surgical incision and a mouse paw UV burn model. We also tested the ability of BW-031 to inhibit cough induced by inhalation of dilute citric acid in guinea pigs. Key Results: BW-031 inhibited Nav1.7 and Nav1.1 channels with ~6-fold greater potency than QX-314 when introduced inside cells and entered capsaicin-activated TRPV1 expressing sensory neurons. BW-031 inhibited inflammatory pain in all three models, producing more effective and longer-lasting inhibition of pain than QX-314 in the mouse UV burn model. BW-031 was also effective in reducing cough counts by 78-90% when applied intratracheally under isoflurane anesthesia or by aerosol inhalation in awake guinea pigs with airway inflammation produced by ovalbumin sensitization. Conclusion and Implications: BW-031 a novel cationic sodium channel inhibitor can be applied locally as a single agent to inhibit inflammatory pain and also effectively inhibits cough in a guinea pig model of nociceptor-activated cough, suggesting a new clinical approach to treating cough.
Ca 2+ -Dependent Maturation of Subtilisin from a Hyperthermophilic Archaeon, Thermococcus kodakaraensis : the Propeptide Is a Potent Inhibitor of the Mature Domain but Is Not Required for Its Folding (2006)

Subtilisin from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 is a member of the subtilisin family. T. kodakaraensis subtilisin in a proform (T. kodakaraensis pro-subtilisin), as well as its propeptide (T. kodakaraensis propeptide) and mature domain (T. kodakaraensis mat-subtilisin), were independently overproduced in E. coli, purified, and biochemically characterized. T. kodakaraensis pro-subtilisin was inactive in the absence of Ca2+ but was activated upon autoprocessing and degradation of propeptide in the presence of Ca2+ at 80 degrees C. This maturation process was completed within 30 min at 80 degrees C but was bound at an intermediate stage, in which the propeptide is autoprocessed from the mature domain (T. kodakaraensis mat-subtilisin*) but forms an inactive complex with T. kodakaraensis mat-subtilisin*, at lower temperatures. At 80 degrees C, approximately 30% of T. kodakaraensis pro-subtilisin was autoprocessed into T. kodakaraensis propeptide and T. kodakaraensis mat-subtilisin*, and the other 70% was completely degraded to small fragments. Likewise, T. kodakaraensis mat-subtilisin was inactive in the absence of Ca2+ but was activated upon incubation with Ca2+ at 80 degrees C. The kinetic parameters and stability of the resultant activated protein were nearly identical to those of T. kodakaraensis mat-subtilisin*, indicating that T. kodakaraensis mat-subtilisin does not require T. kodakaraensis propeptide for folding. However, only approximately 5% of T. kodakaraensis mat-subtilisin was converted to an active form, and the other part was completely degraded to small fragments. T. kodakaraensis propeptide was shown to be a potent inhibitor of T. kodakaraensis mat-subtilisin* and noncompetitively inhibited its activity with a Ki of 25 +/- 3.0 nM at 20 degrees C. T. kodakaraensis propeptide may be required to prevent the degradation of the T. kodakaraensis mat-subtilisin molecules that are activated later by those that are activated earlier.
[Piecewise Fourier analysis of images and the role of the occipital, temporal and parietal cortex in visual perception]. (1978)

On the basis of previously published data, a neuronal scheme of organization of the visual perception in the cerebral cortex, is suggested. An idea of neuronal module is introduced: a cylinder of cortical neurons whose receptive fields are directed towards the same area of the visual field and respond to different spatial frequencies and orientations. A system of overlapping modules is able of piece--wise Fourier--description of portions of the image. The modules of the Clare--Bishop area are composed of receptive fields of different size. Owing to that each neuron of the module projects inhibitory influence upon other neurons, the module acts as a filter picking out the texture. Therefore, the modules of the Clare--Bishop area single out and supply Fourier--description of subimages, the latters being characterized by the same local spectrum within their own limits. The lower portiön of temporal cortex performs a rough identification of subimages and images with the aid of systems of learning neurons. The parietal cortex conforms the description from temporal cortex to the complete description in the modules of occipital cortex, thus performing the transition from an image to a concrete picture.
Comparable Instrumented Knee Joint Laxity and Patient-Reported Outcomes After ACL Repair With Dynamic Intraligamentary Stabilization or ACL Reconstruction: 5-Year Results of a Randomized Controlled Trial (2022)

DRKS00015466 (German Clinical Trials Register).
Noise robust digit recognition using a glottal radar sensor for voicing detection (2004)

A voicing feature is used in concatenation to MFCC features to increase the performance of digit recognition at both low and high SNRs. The problem of noise robust extraction of the voicing feature is solved by using the glottal electromagnetic sensor (GEMS). The GEMS device provides reliable voicing information at all SNRs and noise environments. It is shown that although the voicing feature increases the performance for the clean speech case, the relative improvement for the noisy case is significantly higher for a digit recognition task. Our results indicate that the GEMS device can solve the fundamental problem of extracting reliable voicing information in noisy environments.
Regulating complex geometries using layered depth‐normal images for rapid prototyping and manufacturing (2013)

Purpose Most layer‐based rapid prototyping systems use polygonal models as input. In addition, the input polygonal models need to be manifold and water‐tight; otherwise the built objects may have defects or the building process may fail in some cases. This paper aims to present a regulation method of an arbitrarily complex polygonal model for rapid prototyping and manufacturing applications. Design/methodology/approach The method is based on a semi‐implicit representation of a solid model named the layered depth‐normal images (LDNI), which sparsely encodes the shape boundary of a polygonal model in three orthogonal directions. In the method, input polygonal models or parametric equations are first converted into LDNI models. A regulation operator based on the computed LDNI models is presented. A volume tiling technique is developed for very complex geometries and high accuracy requirements. From the processed LDNI model, an adaptive contouring method is presented to construct a cell representation that includes both uniform and octree cells. Finally, two‐manifold and water‐tight polygonal mesh surfaces are constructed from the cell representation. Findings The LDNI‐based mesh regulation operation can be robust due to its simplicity. The accuracy of the generated regulated models can be controlled by setting LDNI pixel width. Parallel computing techniques can be employed to accelerate the computation in the LDNI‐based method. Experimental results on various CAD models demonstrate the effectiveness and efficiency of our approach for complex geometries. Research limitations/implications The input polygonal model is assumed to be closed in our method. The regulated polygonal model based on our method may have a big file size. Originality/value A novel mesh regulation method is presented in this paper. The method is suitable for rapid prototyping and manufacturing applications by achieving a balance between simplicity, robustness, accuracy, speed and scalability. This research contributes to the additive manufacturing development by providing a digital data preparation method and related tools.
Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings (1995)

Conference Article| November 01 1995 Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings J. F. Couse; J. F. Couse *Receptor Biology Section, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709 Search for other works by this author on: This Site PubMed Google Scholar S. W. Curtis; S. W. Curtis *Receptor Biology Section, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709 Search for other works by this author on: This Site PubMed Google Scholar T. F. Washburn; T. F. Washburn *Receptor Biology Section, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709 Search for other works by this author on: This Site PubMed Google Scholar E. M. Eddy; E. M. Eddy †Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709 Search for other works by this author on: This Site PubMed Google Scholar D. W. Schomberg; D. W. Schomberg ‡Departments of Obstetrics & Gynecology and Cell Biology, Duke University Medical Center, Duke University, Durham, NC 27710, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar K. S. Korach K. S. Korach § *Receptor Biology Section, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709 §To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1995) 23 (4): 929–935. https://doi.org/10.1042/bst0230929 Article history Received: June 14 1995 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation J. F. Couse, S. W. Curtis, T. F. Washburn, E. M. Eddy, D. W. Schomberg, K. S. Korach; Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings. Biochem Soc Trans 1 November 1995; 23 (4): 929–935. doi: https://doi.org/10.1042/bst0230929 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: EGF, epidermal growth factor, ER, oestrogen receptor, ERKO, mouse homozygous for ER gene disruption, G6-PD, glucose 6-phosphate dehydrogenase, LH, luteinizing hormone, NEO, neomycin, PGK, phosphoglycerate kinase, PR, progesterone receptor This content is only available as a PDF. © 1995 Biochemical Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.