gebhart/patrepeval huggingface dataset:
Testing and evaluation of dynamic energy simulations for the development of an intelligent management of energy for the ADREAM smart building (2017)

Having 6500 integrated sensors and a wide network of embedded systems, ADREAM can be categorized as one of the prototype smart buildings of France. As needs for intelligent management of energy on a city scale are growing, the ADREAM project provides a multidisciplinary platform of experimentation, developing solutions for efficient Energy Networks and Smart Grids. This paper provides the description of the project along with an overview of the various energy and control systems installed. Three different modeling techniques are presented, illustrating their strengths and limitations on simulating the thermal behavior of the building and the functioning of the different energy systems. A thermal model of the building was developed and calibrated for thermal analysis and energy consumption prediction, using the software Pleiades+Comfie. A “black box” model was developed for the simulation of energy system parameters and the exploration of efficient control strategies. A modeling technique using Dynamic Neural Networks was also developed for a more precise modeling of the various systems and their outputs. The conclusion addresses the utility of exploring and combining different types of models for optimizing the energy management of Smart Buildings.
Periodic branched structures in a phase-separated magnetic colloid (1994)

Periodic branched columns are observed for the first time in a layer of phase-separated magnetic colloid confined in a cell. The periodicity \ensuremath{\lambda} scales with the layer thickness L. In the thin limit, where no branching occurs, \ensuremath{\lambda}\ensuremath{\propto}${\mathit{L}}^{1/2}$. In the thick limit, each column develops a tree structure with branches and roots, and the columns are separated by shrubs while the scaling relation crosses over to \ensuremath{\lambda}\ensuremath{\propto}${\mathit{L}}^{2/3}$.
Current state of the art, challenges and future directions for audio watermarking (2003)

Transparent data embedding algorithms embed binary streams in host multimedia signals. The embedded data is perceptually inaudible to maintain the quality of the source data. The embedded data can add features to the host multimedia signal or provide copyright protection. We review developments and requirements in transparent data embedding techniques for audio signals. We describe our latest audio embedding algorithm and include experimental results indicating robustness to low bit rate MPEG-Layer 3, AAC, and Dolby AC-3 coding. We conclude with a discussion of future research directions.
GILT modulates CD4+ T cell tolerance to cutaneous autoantigen TRP1 (123.32) (2012)

Abstract Maintaining tolerance to skin-restricted antigens is critical for avoiding cutaneous autoimmunity. We have shown that gamma-interferon-inducible lysosomal thiol reductase (GILT) is essential for efficient MHC class II-restricted processing of the melanocyte differentiation antigen, tyrosinase-related protein 1 (TRP1). In GILT-/- TRP1-specific TCR transgenic (Tg) mice, CD4+ TRP1-specific T cells escape thymic deletion, but do not induce autoimmune destruction of melanocytes (vitiligo). GILT-/- Tg mice have fewer peripheral CD4+ TRP1-specific T cells compared to TRP1-deficient mice. CD4+ T cells in GILT-/- Tg mice have marked reduced IL-2 and IFN-γ production and a portion are antigen-experienced. Since tolerance is only partially mediated by an increased percentage of TRP1-specific regulatory T cells in GILT-/- mice, we sought to characterize other mechanisms that constrain the activity of TRP1-specific T cells, such as anergy, exhaustion and deletion. Here, we demonstrate that fewer TRP1-specific T cells were recovered from skin-draining lymph nodes following adoptive transfer of CD4+ T cells from GILT-/- Tg compared to TRP1-deficient Tg mice. Furthermore, TRP1-specific T cells from GILT-/- Tg mice underwent diminished antigen-specific proliferation in vitro compared to T cells from TRP1-deficient Tg mice. These findings suggest multiple peripheral tolerance mechanisms inhibit CD4+ T cell mediated autoimmunity to an endogenously expressed cutaneous autoantigen.
Troubleshooting of 3G LTE mobility parameters using iterative statistical model refinement (2009)

This paper presents a new troubleshooting methodology for 3G Long Term Evolution (LTE) networks based on a closed-form expression between Radio Resource Management (RRM) and Key Performance Indicator (KPI) parameters, using statistical learning. This methodology aims at locally optimising the RRM parameters of the cells with poor performance in an iterative manner. The optimization engine uses the closed-form relationship to calculate the optimized RRM parameters for these cells. The main advantage of this methodolgy is the small number of iterations required to achieve convergence and the QoS objective. A troubleshooting application scenario involving mobility in LTE networks is considered. Numerical simulations illustrate the benefits of our proposed scheme.
Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex (2014)

Sortilin is a type I membrane glycoprotein belonging to the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors and is most abundantly expressed in the central nervous system. Sortilin has emerged as a key player in the regulation of neuronal viability and has been implicated as a possible therapeutic target in a range of disorders. Here, the identification of AF40431, the first reported small-molecule ligand of sortilin, is reported. Crystals of the sortilin-AF40431 complex were obtained by co-crystallization and the structure of the complex was solved to 2.7 Å resolution. AF40431 is bound in the neurotensin-binding site of sortilin, with the leucine moiety of AF40431 mimicking the binding mode of the C-terminal leucine of neurotensin and the 4-methylumbelliferone moiety of AF40431 forming π-stacking with a phenylalanine.
Cloning of mouse 17β-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues (1997)

17beta-Hydroxysteroid dehydrogenases (17HSDs) are responsible for the conversion of low-activity sex steroids to more potent forms, and vice versa. 17HSD activity is essential for the biosynthesis of sex steroids in the gonads, and it is also one of the key factors regulating the availability of active ligands for sex-steroid receptors in various extragonadal tissues. In this study, we have characterized mouse 17HSD type 2 cDNA, and analysed the relative expression of 17HSD types 1, 2, 3, 4 and 5 mRNAs in mouse embryos and adult male and female tissues. The cDNA characterized has a open reading frame of 1146 bp, and encodes a protein of 381 amino acids with a predicted molecular mass of 41837 kDa. Northern-blot analysis of adult mouse tissues revealed that, of the different 17HSDs, the type 2 enzyme is most abundantly expressed. High expression of the enzyme, which oxidizes both testosterone and oestradiol, in several large organs of both sexes indicates that it is the isoform having the most substantial role in the metabolism of sex steroids. Interestingly, four of the five 17HSD enzymes were also detected by Northern blots of whole mouse embryos, and each of the enzymes showed a unique pattern of expression. The oestradiol-synthesizing type 1 enzyme predominates in early days of development embryonic day 7, but after that the oxidative type 2 enzyme becomes the predominant form of all 17HSDs. The data therefore suggest that there is transient oestradiol production in the early days of embryonic development, after which inactivation of sex steroids predominates in the fetus and placenta.
Design of a multispectral, wedge filter, remote-sensing instrument incorporating a multiport, thinned, CCD area array (1995)

The next generation Wedge Imaging Spectrometer (WIS) instruments currently in integration at Hughes SBRD incorporate advanced features to increase operation flexibility for remotely sensed hyperspectral imagery collection and use. These features include: a) multiple linear wedge filters to tailor the spectral bands to the scene phenomenology; b) simple, replaceable fore-optics to allow different spatial resolutions and coverages; c) data acquisition system (DAS) that collects the full data stream simultaneously from both WIS instruments (VNIR and SWIR/MWIR), stores the data in a RAID storage, and provides for down-loading of the data to MO disks; the WIS DAS also allows selection of the spectral band sets to be stored; d) high-performance VNIR camera subsystem based upon a 512 X 512 CCD area array and associated electronics.
Rationale for estimating genealogical coancestry from molecular markers (2011)

International audience
Transport Properties of the Galactose-binding Protein of Escherichia coli (1971)

The galactose-binding protein of Escherichia coli is shown to exist in two forms, each representing different conformational states. These two forms are in equilbrium with each other, and exhibit binding affinities toward galactose that differ by at least a factor of 10. These properties of the galactose-binding protein are in agreement with the requirements postulated for a carrier molecule involved in active transport. The active transport of galactose through the cell membrane would then involve preferential association of galactose to State I of the protein (highly binding active) on the outside of the cell membrane and subsequent dissociation of galactose from State II (less binding active) on the inside of the membrane. The energy necessary for accumulation of galactose inside the cell might be explained by an energy-dependent continuous transformation from one state to the other followed by an energy independent reversal of this reaction. The maintenance of the different forms of the binding protein on respective sides of the cell membrane could thus explain active transport of galactose in E. coli.
Scalable Decipherment for Machine Translation via Hash Sampling (2013)

In this paper, we propose a new Bayesian inference method to train statistical machine translation systems using only nonparallel corpora. Following a probabilistic decipherment approach, we first introduce a new framework for decipherment training that is flexible enough to incorporate any number/type of features (besides simple bag-of-words) as side-information used for estimating translation models. In order to perform fast, efficient Bayesian inference in this framework, we then derive a hash sampling strategy that is inspired by the work of Ahmed et al. (2012). The new translation hash sampler enables us to scale elegantly to complex models (for the first time) and large vocabulary/corpora sizes. We show empirical results on the OPUS data—our method yields the best BLEU scores compared to existing approaches, while achieving significant computational speedups (several orders faster). We also report for the first time—BLEU score results for a largescale MT task using only non-parallel data (EMEA corpus). 1
Study of Flow-Induced Hemolysis Using Novel Couette-Type Blood-Shearing Devices (2011)

To assist the development and application of blood-contacting medical devices, two novel flow-through Couette-type blood-shearing devices have been developed to study the quantitative relationship between blood damage indexes and flow-dependent parameters. One device is an axial flow-through Couette-type device supported by a pair of pin bearings adapted from the adult Jarvik 2000 blood pump. The other is a centrifugal flow-through Couette-type device supported with magnetic bearings adapted from the CentriMag blood pump. In both devices, a rotor spindle was used to replace the original impeller blades so that a small gap was created between the housing and the rotating spindle surface. Computational fluid dynamics simulations have shown that a uniform, high shear stress region can be generated inside the small gap while the shear stresses elsewhere are relatively low. The possibility of secondary blood damage caused by mechanical seals was eliminated due to the use of a magnetic rotor system. Blood flow through the gap was driven by an externally pressurized reservoir. By adjusting the rotational speed and blood flow rate, shear-induced hemolysis was quantified at a matrix of exposure time (0.039 to 1.48 s) and shear stress (50 to 320 Pa). All of the experiments were conducted at room temperature using heparinized ovine blood with a hematocrit value of 30%. The measured hemolysis levels were much lower than those published in the literature, and the overestimation of those earlier studies may be attributable to device-related secondary blood-damaging effects. A new set of coefficients for the power law model was derived from the regression of the experimental data.
New Steroidal Saponins and Sterol Glycosides from Paris polyphylla var. yunnanensis (2012)

Four new steroidal saponins, pariposides A-D (1-4), and two new sterol glycosides, pariposides E-F (5-6), along with eight known steroidal saponins (7-14), two known sterol glycosides (15-16), and two known ecdysteroids (17-18), were isolated from the roots of Paris polyphylla var. yunnanensis. Among them, compounds 1-4 are the first spirostanol saponins with a peroxy group located between C-5 and C-8 of the aglycone. Their structures were determined by detailed spectroscopic analyses and chemical methods. All the isolated compounds were evaluated for their in vitro cytotoxicities against human nasopharyngeal carcinoma epithelial (CNE) cells, and steroidal saponins 7, 11, 13, and 14 showed a potent antiproliferative effect on CNE cells with IC₅₀ values of 9.2, 4.7, 11.1, and 2.7 µM, respectively.
Direct Single Impinging Jet Cooling of a <sc>mosfet</sc> Power Electronic Module (2017)

This paper presents an approach of direct liquid jet impingement cooling of a typical MOSFET power module. A single micro water jet was installed for cooling the upper surface of a MOSFET semiconductor package. In contrast to standard cooling methods, this approach focuses on hot spot removal omitting any kind of heat spreading device. The cooling chamber was directly soldered to the MOSFET cover that represents a very efficient way of liquid cooling. Two different configurations with and without electrical insulation (TIM) were used to investigate the importance of insulating material. In the range of 10-100 mL/min coolant flow rates at an inlet temperature of 22.5 °C a maximum power distribution of 51 W (at 30 mL/min) next to a maximum measured MOSFET temperature of 163 °C could be realized. Heat transfer coefficients up to 12 000 W/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> · K were achieved using only 10.8 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> of assembly space for the cooling device. With electrical insulation, the heat transfer coefficient exceeded 6000 W/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> · K at a coolant flow rate of 30 mL/min and pumping power of 3 mW. The results illustrate the potential of direct liquid cooling using impinging microjets in combination with a compact injection chamber. The individual cooling of semiconductors offers new perspectives in the design of power electronic modules.
Mode of action of a new nalidixic acid derivative, AB206 (1980)

A new chemotherapeutic agent, AB206, shows potent antibacterial activity against gram-negative bacteria, including most of the nalidixic acid-resistant strains tested. It strongly inhibits deoxyribonucleic acid (DNA) synthesis in Escherichia coli, but only slightly inhibits ribonucleic acid and protein synthesis. Its activity on DNA synthesis in vivo and in vitro is greater than that of nalidixic acid. AB206 also strongly inhibits in vivo DNA synthesis in nalidixic acid-susceptible and -resistant clinical isolates of Proteus and Serratia. AB206 shows high penetrability into E. coli cells, as demonstrated by antibacterial activity with or without ethylenediaminetetraacetic acid, inhibition of in vivo and in vitro DNA synthesis, and uptake of the drug into cells, as compared to nalidixic acid. It appears that the high antibacterial activity of AB206 may be explained both by its potent inhibitory action against DNA synthesis and also by its high penetrability into bacterial cells.
Pneumococcal Vaccine: Dose, Revaccination, and Coadministration with Influenza Vaccine (1979)

Current pneumococcal vaccine contains 14 specific capsular polysaccharide antigens, each in 50-γg amount. Reduction of dosage to 25 or 12.5 γg per type gave reduced antibody responses in human subjects for most of the serotypes and these were less than current requirements of the U.S. Food and Drug Administration. Specific antibody following vaccination declines slowly and there was no worthwhile increase in antibody on revaccination 1 to 1.5 years following prior vaccination. Reduction in the dosage of antigen to one-half or one-fourth the 50 γg per antigen amount eliminated the enhanced local and systemic reactions noted previously when the full vaccine amount was given but the time interval between vaccination and revaccination was not long enough to test for the ability of the reduced dose to restimulate antibody production. Pneumococcal and influenza virus vaccines given at the same time into opposite arms showed no important reduction in antibody response to either vaccine and there was no increase in local or systemic reactions compared with that found when the vaccines were given alone.
Coexistence of Decentralized Congestion Control Algorithms for V2V Communication (2018)

Channel congestion is one of the most critical issues in IEEE 802.11p-based vehicular communications as it leads to the unreliability of safety applications. As a countermeasure, many Decentralized Congestion Control (DCC) algorithms have been proposed. One of the most prominent DCC algorithms is the message-rate based LIMERIC. Recently, algorithms have also been proposed to support higher vehicle density (better scalability). One of such algorithms is the combined message-rate and data-rate based congestion control algorithm (MD-DCC). MD-DCC can support around 2.7 times higher vehicular density than LIMERIC. However, if LIMERIC has been deployed, can MD-DCC be introduced and coexist well with LIMERIC. The objective of this paper is to investigate how MD-DCC coexists with LIMERIC. Given a scenario where vehicles may use either LIMERIC or MD-DCC, we study the impact of coexistence on channel load, fairness and reliability of vehicles at different densities. Simulation studies show that there is no significant degradation of reliability both for LIMERIC and MD-DCC at different densities. On the contrary, coexistence can improve the reliability of LIMERIC vehicles. Furthermore, MD-DCC can support vehicles at large densities even when it coexists with LIMERIC retaining its scalability. However, fair allocation of resources is not guaranteed when LIMERIC and MD-DCC coexist.
Investigation of the time dependent nature of infrasound measured near a wind farm (2014)

It is well-known that wind farm noise is dominated by low-frequency energy at large distances from the wind farm, where the high frequency noise has been more attenuated than low-frequency noise. It has also been found that wind farm noise is highly variable with time due to the influence of atmospheric factors such as atmospheric turbulence, wake turbulence from upstream turbines and wind shear, as well as effects that can be attributed to blade rotation. Nevertheless, many standards that are used to determine wind farm compliance are based on overall A-weighted levels which have been averaged over a period of time. Therefore the aim of the work described in this paper is to investigate the time dependent nature of unweighted wind farm noise and its perceptibility, with a focus on infrasound. Measurements were carried out during shutdown and operational conditions and results show that wind farm infrasound could be detectable by the human ear although not perceived as sound.
Effect of styrene‐4‐vinyl pyridine diblock copolymer on morphological, thermal, and mechanical properties of poly(2,6‐dimethyl‐1,4‐phenylene ether)/polyethylene ionomer blends (1994)

Abstract The compatibilizing effects of a styrene‐4‐vinyl pyridine diblock copolymer on the properties of immiscible poly(2,6‐dimethyl‐1,4‐phenylene ether) (PPE)/polyethylene ionomer (Surlyn) blends are investigated by examining the phase morphology and the thermal and mechanical properties. The block copolymer is synthesized by sequential anionic polymerization at −78°C and melt‐mixed with PPE and Surlyn at 290°C. When a small amount of block copolymer is present, the domain size of the dispersed phase becomes smaller. The tensile strength and elongation at break increase with addition of the block copolymer for PPE‐rich matrix blends, whereas the tensile strength increases but the elongation at break decreases for Surlyn‐rich matrix blends. These effects are interpreted in terms of the interfacial activity and the reinforcing effect of the block copolymer. From the experimental results, it is concluded that the block copolymer plays a role as an effective compatibilizer for PPE/Surlyn blends. © 1994 John Wiley &amp; Sons, Inc.
Desktop Simulator Demonstration of a Joint Human/Automated Upset Recovery System (2012)

reduce loss of life. This paper presents the development and initial testing of a joint human/automated (H/A) recovery system intended to assist the crew with recovery from upset conditions. The goal of the system is to keep pilots in the loop, leveraging their expertise while simultaneously conveying information about recovery procedures in an intuitive and unobtrusive manner. This research builds on recent work by the authors targeted at autonomous upset recovery for unmanned aerial vehicles. The authors have developed a number of crew-specic extensions to this automated system at both the architecture and interface levels. The resulting system optimizes recovery strategies oine, stores the recovery procedures in a compact manner that can easily be queried in real-time online, and communicates the procedure to the pilot through visual and haptic cues. The system was evaluated in a small-scale pilot-in-the-loop study. Three pilots with dierent backgrounds as well as dierent levels of experience were recruited to take part in the pilot-in-the-loop experiments. Metrics were dened to evaluate performance both in terms of quantitative recovery metrics (e.g. how fast did the vehicle recover nominal ight?)