gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Solution Synthesis of Germanium Nanocrystals Demonstrating Quantum Confinement. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells (2015)

The glucose transporter GLUT1 is frequently overexpressed in most tumor tissues because rapidly proliferating cancer cells rely primarily on glycolysis, a low-efficiency metabolic pathway that necessitates a very high rate of glucose consumption. Because blocking GLUT1 is a promising anticancer strategy, we developed a novel class of GLUT1 inhibitors based on the 4-aryl-substituted salicylketoxime scaffold. Some of these compounds are efficient inhibitors of glucose uptake in lung cancer cells and have a notable antiproliferative effect. In contrast to their 5-aryl-substituted regioisomers, the newly synthesized compounds reported herein do not display significant binding to the estrogen receptors. The inhibition of glucose uptake in cancer cells by these compounds was further observed by fluorescence microscopy imaging using a fluorescent analogue of glucose. Therefore, blocking the ability of tumor cells to take up glucose by means of these small molecules, or by further optimized derivatives, may be a successful approach in the development of novel anticancer drugs.
Deep-ultraviolet light generation in ZBLAN photonic crystal fibre pumped at 800 nm and 1042 nm (2015)

We report recent progress on the fabrication of photonic crystal fibre from ZBLAN glass and its application to generate deep-ultraviolet to mid-infrared supercontinua from short-pulse infrared pump lasers.
Analysis of thread workgroup broadcast for Intel GPUs (2016)

As hardware becomes more flexible in terms of programming, software APIs must expose hardware features in a portable way. Thread to thread communication is being exposed in OpenCL 2.0 through the newly defined work-group functions. In this paper we analyze the work-group broadcast functionality in the OpenCL compiler backend for Intel's GPUs. We first describe the particularities of Intel's GEN GPU architecture and the Beignet OpenCL open source project. Then we describe the work-group broadcast implementation which uses shared local memory read/write for thread to thread communication. Finally we analyze the performance and on how the implementation maps to hardware, motivating the design decisions.
Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets. (1992)

In order to further evaluate the role of protein kinase C activation in glucose-induced insulin secretion, the extent of phosphorylation of the myristoylated alanine-rich C kinase substrate (MARCKS) was examined in freshly isolated rat pancreatic islets prelabeled with [32P]orthophosphate. The islets were incubated with either 2.75 mM glucose alone, 2.75 mM glucose + 1 microM phorbol myristate acetate, 20 mM glucose, or 20 mM glucose + 50 nM staurosporine. After stimulation, the homogenized islets were processed by immunoprecipitation with a specific polyclonal anti-MARCKS antibody, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Densitometric analysis of autoradiograms revealed that phorbol myristate acetate caused a 3.78 +/- 0.97-fold increase in MARCKS phosphorylation over control. In the islets exposed to 20 mM glucose, an increase of 3.43 +/- 0.46-fold over control was observed. In islets exposed to G20 + 50 nM staurosporine, MARCKS phosphorylation was inhibited by 90 +/- 4% compared with control islets exposed to 20 mM glucose alone. Islets similarly treated (but incubated without 32P) were examined by immunocytochemistry using an alpha-PKC-specific monoclonal antibody and visualized by confocal immunofluorescence microscopy. The alpha-PKC redistributed from the cytosol to the plasma membrane in the beta-cells of islets exposed to 20 mM glucose. In separate experiments, unlabeled but similarly treated islets were shown to respond with a 5-7-fold increase in insulin secretion in static incubation. Thus, when freshly isolated rat pancreatic islets are exposed to stimulatory glucose concentrations, they exhibit both a translocation of alpha-PKC and a significant increase in the extent of phosphorylation of MARCKS protein. These data suggest that alpha-PKC is activated during glucose-induced insulin secretion.
Impaired venous hemodynamics in a minority of patients with chronic leg ulcers due to sickle cell anemia. (2001)

Venous insufficiency may contribute to the development of leg ulcers in a minority of sickle cell anemia patients. A minority of sickle cell anemia patients with chronic leg ulcers can be shown to have leg venous reflux by duplex ultrasound imaging.
Hearing evaluation of patients with head and neck cancer: Comparison of Common Terminology Criteria for Adverse Events, Brock and Chang adverse event criteria in patients receiving cisplatin (2014)

The Brock and Chang tools may be superior to the CTCAE in patients with head and neck cancer receiving CDDP using baseline hearing loss distribution, interobserver agreement, and detection of hearing loss grade change as performance indicators.
A False-Positive Case of Methylmalonic Aciduria by Tandem Mass Spectrometry Newborn Screening Dependent on Maternal Malnutrition in Pregnancy (2020)

Methylmalonic Acidurias (MMAs) are a group of inborn errors of metabolism (IEMs), specifically of propionate catabolism characterized by gastrointestinal and neurometabolic manifestations resulting from a deficiency in the function of methylmalonyl-CoA mutase, methylmalonyl-CoA epimerase, and cobalamin metabolism. In Expanded Newborn Screening (NBS), increased levels of propionylcarnitine (C3) and/or of its ratios by MS/MS analysis of dried blood spots (DBS) samples are suggestive for either Propionic Acidemia or MMAs. C3 elevation is not considered a specific marker for these disorders, resulting in high false-positive rates. The use of analyte ratios improves specificity, but it still cannot resolve the diagnostic issue. Second-tier testing are strongly recommended as confirmation of primary NBS results and for a differential diagnosis. LC-MS/MS analysis allows the quantification of more specific markers of the disorder. Here, we report the case of a newborn with a suspected MMA at Expanded NBS and at second-tier test. Given the urgent situation, in-depth diagnostic investigations were performed. Further investigations surprisingly revealed a Vitamin B12 deficiency due to a maternal malnutrition during pregnancy. This case emphasized that metabolic alterations at NBS may not only be influenced by genome and related to IEMs, but also to external factors and to maternal conditions.
Physiological responses to maximal effort wheelchair and arm crank ergometry (1980)

The purpose of this investigation was to compare physical work capacity (PWC), peak oxygen uptake (peak VO2), maximal pulmonary ventilation (VEmax), maximal heart rate (HRmax), and maximal blood lactate concentration (LAmax) for wheelchair ergometer (WERG) and arm crank ergometer (ACE) exercise. For this, wheelchair-dependent (n = 6) and able-bodied (n = 10) subjects completed a progressive intensity, discontinuous test for each mode of exercise. Each test was terminated by physical exhaustion and/or an inability to maintain a flywheel velocity of 180 m.min-1. Relatively high correlation coefficients were found between values obtained during the two modes of ergometry for PWC, peak VO2, VEmax, and HRmax. WERG exercise was found to elicit a significantly (P less than 0.05) lower PWC (by 36%), HRmax (by 7%), and LAmax (by 26%) than ACE exercise. Peak VO2 and VEmax, however, were similar for both exercise modes. These data suggest that either exercise mode may be used for fitness testing and training of people who cannot use their legs and that arm cranking may be a superior method to propel wheelchairs.
The Challenge of Delivering Wireless Video - Message from the editor-in-chief (2005)

Presents the editorial for this issue of the publication.
Analysis of Host Species Specificity of Magnaporthe grisea Toward Foxtail Millet Using a Genetic Cross Between Isolates from Wheat and Foxtail Millet (2003)

ABSTRACT Host species specificity of Magnaporthe grisea toward foxtail millet was analyzed using F(1) cultures derived from a cross between a Triticum isolate (pathogenic on wheat) and a Setaria isolate (pathogenic on foxtail millet). On foxtail millet cvs. Beni-awa and Oke-awa, avirulent and virulent cultures segregated in a 1:1 ratio, suggesting that a single locus is involved in the specificity. This locus was designated as Pfm1. On cv. Ki-awa, two loci were involved and one of them was Pfm1. The other locus was designated as Pfm2. Interestingly, Pfm1 was not involved in the pathogenic specificity on cv. Kariwano-zairai. These results suggest that there is no "master gene" that determines the pathogenic specificity on all foxtail millet cultivars and that the species specificity of M. grisea toward foxtail millet is governed by cultivar-dependent genetic mechanisms that are similar to gene-for-gene interactions controlling race-cultivar specificity.
Characterization of sulfated glucuronic acid containing glycolipids reacting with IgM M-proteins in patients with neuropathy. (1987)

In some patients with neuropathy and plasma cell dyscrasia, the serum IgM M-proteins are known to bind to the myelin associated glycoprotein and to peripheral nerve glycolipids. We have isolated two acidic glycolipids which bind to the M-protein from human cauda equina by DEAE-Sephadex, Iatrobeads, and high performance liquid column chromatographies. The major acidic glycolipid migrated between GM1 and GD1a and the minor acidic glycolipid migrated between GD1a and GD1b. Their structures were elucidated by sugar analysis, enzymatic digestion, mild acid hydrolysis, permethylation, fast atom bombardment mass spectrometry, and NMR studies. Their core structure was confirmed to be paragloboside by high performance thin-layer chromatography-immunostaining using anti-paragloboside monoclonal antibody. Both acidic glycolipids lacked sialic acid but contained sulfated glucuronic acid as their acidic moiety. The sulfate group in the glucuronic acid was established by periodate oxidation and permethylation studies to be attached to the 3 position. The structures of the two acidic glycolipids are therefore consistent with the following: IV3GlcUA(3-sulfate)nLcOse4Cer and VI3GlcUA(3-sulfate)nLcOse6Cer. Additionally, the free carboxyl group on the glucuronic acid residue was shown to be necessary to bind the IgM M-proteins from neuropathy patients.
Dilution Jet Experiments in Compact Combustor Configurations (1983)

The effects of cooling jets on the velocity and temperature fields in a compact reverse flow combustion are discussed. The work is motivated by the need to limit the temperature of past-combustion gases in jet engines to values within the endurance capabilities of turbine blades. The application requires not only that the temperature be kept sufficiently low but also that a suitably tailored temperature profile be provided at the combustor exit, with higher temperatures generally permissible at the blade tip than at the blade root because of higher centrifugal loads at the root. A single jet. As spacing is reduced, jet penetration is also reduced, and the cooling jets tend to remain close to the wall from which they are injected. Results suggest that cooling and temperature distribution tailoring can be accomplished without injecting cooling jets upstream of the turn, and thus it appears that combustors can be made smaller than current designs.
Presence of fucosyl residues on the oligosaccharide antennae of membrane glycopeptides of human neuroblastoma cells. (1983)

Fucosyl residues linked alpha 1 leads to 3 or 4 to N-acetylglucosamine were found in large amounts on glycopeptides from the membranes of human tumor cells of neurectodermal origin but not on membrane glycopeptides from human fibroblasts. The fucosyl residues were detected by release of radioactive fucose from the glycopeptides with an almond alpha-L-fucosidase specific for fucosyl alpha 1 leads to 3(4)-N-acetylglucosamine. In other studies, the linkage was shown to be alpha 1 leads to 3 by nuclear magnetic resonance analysis (U. V. Santer, M. C. Glick, H. van Halbeek, and J. F. G. Vliegenthart. Carbohydr. Res., 118: in press, 1983). Glycopeptides containing these fucosyl residues from four human neuroblastoma cell lines were defined by binding to immobilized lectins. In addition, the glycopeptides from one human neuroblastoma cell line, CHP-134, were further characterized by enzyme degradation and columns calibrated for size and charge. The antennary position of fucosyl alpha 1 leads to 3-N-acetylglucosamine on the glycopeptides was demonstrated by the use of exoglycosidases and endoglycosidase D, since complete degradation to yield fucosyl-N-acetylglucosaminylasparagine was obtained only after treatment with almond alpha-L-fucosidase prior to the sequential degradation. Fucosyl alpha 1 leads to 3-N-acetylglucosamine was present on most size and charge classes of membrane glycopeptides and therefore was not limited to a few glycoproteins. Since the almond alpha-L-fucosidase cleaves fucosyl residues from glycoproteins, the physiological effects of the increased specific fucosylation on human tumors of neurectodermal origin can be examined.
Software versioning quality parameters: Automated assessment tools based on the parameters (2016)

Version Control System (VCS) is used by software developers during a software development project with the purpose for maintaining versions and collaborative work. It is a part of configuration management. Developers work together using the same environment. Though all developers must follow the same best practices, each developer may work individually with different practices due to different knowledge and experience of using VCS. Many best practices are available, but they are different. In this paper, we define quality parameters based on quality factors. The quality factors and associated metrics are extracted from the log file of VCS. These parameters bear out good software versioning activities. To prove the concept, we build a tool for automatically assessing the quality of versioning activities of a developer, based on the log file of a VCS. The tool has been tested and used for assessing the quality of software versioning of two open source projects. As the result, developers versioning activities can be analysed.
Survey of transfemoral amputee experience and priorities for the user-centered design of powered robotic transfemoral prostheses (2021)

This study's findings support the understanding that when appropriately prescribed according to patient characteristics and needs in the context of a proactive rehabilitation program, advanced transfemoral prostheses promote patient mobility, autonomy, and overall health. Survey data indicate overall stability, modularity, and versatility as key design priorities for the continued development of transfemoral prosthesis technology. Finally, observed associations between prosthesis type, user experience, and attitudes concerning prosthesis ownership suggest both that prosthesis characteristics influence device acceptance and functional outcomes, and that psychosocial factors should be specifically and proactively addressed during the rehabilitation process.
Combining Crop Growth Modeling With Trait-Assisted Prediction Improved the Prediction of Genotype by Environment Interactions (2020)

Plant breeders evaluate their selection candidates in multi-environment trials to estimate their performance in contrasted environments. The number of genotype/environment combinations that can be evaluated is strongly constrained by phenotyping costs and by the necessity to limit the evaluation to a few years. Genomic prediction models taking the genotype by environment interactions (GEI) into account can help breeders identify combination of (possibly unphenotyped) genotypes and target environments optimizing the traits under selection. We propose a new prediction approach in which a secondary trait available on both the calibration and the test sets is introduced as an environment specific covariate in the prediction model (trait-assisted prediction, TAP). The originality of this approach is that the phenotyping of the test set for the secondary trait is replaced by crop-growth model (CGM) predictions. So there is no need to sow and phenotype the test set in each environment which is a clear advantage over the classical trait-assisted prediction models. The interest of this approach, called CGM-TAP, is highest if the secondary trait is easy to predict with CGM and strongly related to the target trait in each environment (and thus capturing GEI). We tested CGM-TAP on bread wheat with heading date as secondary trait and grain yield as target trait. Simple CGM-TAP model with a linear effect of heading date resulted in high predictive abilities in three prediction scenarios (sparse testing, or prediction of new genotypes or of new environments). It increased predictive abilities of all reference GEI models, even those involving sophisticated environmental covariates.
Optical spectroscopy on in vitro fungal diagnosis (2008)

The growing incidence of microbial infections and the increasing ability of such organisms to acquire resistance to antimicrobial treatment lead the requirement of fast bacteria and fungi identification methods. In this work we explored optical spectroscopic techniques on fungal identification. We show that some fungal infections can be identified by ultraviolet optical excitation of fungi fluorescence followed by the spectral analysis of the emitted light. Moreover, we demonstrate that ultraviolet LED and LASER could be applied in fungal identification and a new device for fungal diagnosis is proposed.
Interaction of Adipocyte Metabolic and Immune Functions Through TBK1 (2020)

Adipocytes and adipose tissue play critical roles in the regulation of metabolic homeostasis. In obesity and obesity-associated metabolic diseases, immune cells infiltrate into adipose tissues. Interaction between adipocytes and immune cells re-shapes both metabolic and immune properties of adipose tissue and dramatically changes metabolic set points. Both the expression and activity of the non-canonical IKK family member TBK1 are induced in adipose tissues during diet-induced obesity. TBK1 plays important roles in the regulation of both metabolism and inflammation in adipose tissue and thus affects glucose and energy metabolism. Here we review the regulation and functions of TBK1 and the molecular mechanisms by which TBK1 regulates both metabolism and inflammation in adipose tissue. Finally, we discuss the potential of a TBK1/IKK<i>ε</i> inhibitor as a new therapy for metabolic diseases.
Computer graphics with OpenGL (1986)

For junior- to graduate-level courses in computer graphics. Assuming no background in computer graphics, this junior- to graduate-level textbook presents basic principles for the design, use, and understanding of computer graphics systems and applications. The authors, authorities in their field, offer an integrated approach to two-dimensional and three-dimensional graphics topics. A comprehensive explanation of the popular OpenGL programming package, along with C++ programming examples illustrates applications of the various functions in the OpenGL basic library and the related GLU and GLUT packages.
Brightening of Dark States in CsPbBr3 Quantum Dots Caused by Light‐Induced Magnetism (2021)

Lead halide perovskite quantum dots (QDs) have shown great potential for optoelectronic and quantum photonic applications. Although controversy remains about the electronic fine structures of bulk perovskites due to the strong spin-orbit coupling affecting the conduction bands, compelling evidence indicates that the ground states of perovskite QDs remain dark, limiting their applications in optoelectronic devices. Here, it is demonstrated that photoexcitation can induce large intrinsic magnetic fields in Mn-doped CsPbBr<sub>3</sub> perovskite QDs. Equivalent to applying an external magnetic field, the light-induced field causes giant Zeeman splitting to the bright triplet states and brightens the dark singlet ground state, thus effectively rendering a partially bright ground state in the doped QDs. These findings here may contribute to the understanding of the electronic fine structures in perovskite QDs and demonstrate a potential approach for creating semiconductor nanostructures that can serve as bright light sources.
Active Fences against Voltage-based Side Channels in Multi-Tenant FPGAs (2019)

Dynamic and partial reconfiguration together with hardware parallelism make FPGAs attractive as virtualized accelerators. However, recently it has been shown that multi-tenant FPGAs are vulnerable to remote side-channel attacks (SCA) from malicious users, allowing them to extract secret keys without a logical connection to the victim core. Typical mitigations against such attacks are hiding and masking schemes, to increase attackers' efforts in terms of side-channel measurements. However, they require significant efforts and tailoring for a specific algorithm, hardware implementation and mapping. In this paper, we show a hiding countermeasure against voltage-based SCA that can be integrated into any implementation, without requiring modifications or tailoring to the protected module. We place a properly mapped Active Fence of ring oscillators between victim and attacker circuit, enabled as a feedback of an FPGA-based sensor, leading to reduced side-channel leakage. Our experimental results based on a Lattice ECP5 FPGA and an AES-128 module show that two orders of magnitude more traces are needed for a successful key recovery, while no modifications to the underlying cryptographic module are necessary.
3-D seismic survey design for linear v(z) media (1999)

Abstract The standard formula for bin size is based, ultimately, on constant velocity assumptions. We extend the calculation of bin size and related parameters to media characterized by a linear v(z) velocity function. We present design equations accurate for all dips, including those beyond 90 degrees , and these expressions reduce to known forms in the constant velocity limit. The variable velocity bin size is larger than would be calculated by standard methods, whereas migration distance and travel times are smaller. Since bin size has a first-order effect on acquisition and processing cost, this allows design of cost-efficient 3-D seismic surveys.