gebhart/patrepeval huggingface dataset:
A model-based eco-routing strategy for electric vehicles in large urban networks (2016)

A novel eco-routing navigation strategy and energy consumption modeling approach for electric vehicles are presented in this work. Speed fluctuations and road network infrastructure have a large impact on vehicular energy consumption. Neglecting these effects may lead to large errors in eco-routing navigation, which could trivially select the route with the lowest average speed. We propose an energy consumption model that considers both accelerations and impact of the road infrastructure, also separating the costs of all the possible turning movements in the transportation network by means of the adjoint graph. The approach makes use of only aggregated data available from existing map services. We demonstrate that the proposed strategy is more effective and reliable than the existing approaches in predicting vehicle energy consumption and in suggesting an energy-efficient route.
Nanoparticle–Nanoparticle Interactions in Biological Media by Atomic Force Microscopy (2013)

Particle-particle interactions in physiological media are important determinants for nanoparticle fate and transport. Herein, such interactions are assessed by a novel atomic force microscopy (AFM)-based platform. Industry-relevant CeO2, Fe2O3, and SiO2 nanoparticles of various diameters were made by the flame spray pyrolysis (FSP)-based Harvard Versatile Engineering Nanomaterials Generation System (Harvard VENGES). The nanoparticles were fully characterized structurally and morphologically, and their properties in water and biological media were also assessed. The nanoparticles were attached on AFM tips and deposited on Si substrates to measure particle-particle interactions. The corresponding force was measured in air, water, and biological media that are widely used in toxicological studies. The presented AFM-based approach can be used to assess the agglomeration potential of nanoparticles in physiological fluids. The agglomeration potential of CeO2 nanoparticles in water and RPMI 1640 (Roswell Park Memorial Institute formulation 1640) was inversely proportional to their primary particle (PP) diameter, but for Fe2O3 nanoparticles, that potential is independent of PP diameter in these media. Moreover, in RPMI+10% Fetal Bovine Serum (FBS), the corona thickness and dispersibility of the CeO2 are independent of PP diameter, while for Fe2O3, the corona thickness and dispersibility were inversely proportional to PP diameter. The present method can be combined with dynamic light scattering (DLS), proteomics, and computer simulations to understand the nanobio interactions, with emphasis on the agglomeration potential of nanoparticles and their transport in physiological media.
Near-Field Stacking of Zone Plates in the X-Ray Range (2002)

We use Fresnel zone plates as focusing optics in hard x-ray microprobes at energies typically between 6 and 30 keV. While a spatial resolution close to 0.1 {micro}m can currently be achieved, highest spatial resolution is obtained only at reduced diffraction efficiency due to manufacturing limitations with respect to the aspect ratios of zone plates. To increase the effective thickness of zone plates, we are stacking several identical zone plates on-axis in close proximity. If the zone plates are aligned laterally to within better than an outermost zone width and longitudinally within the optical near-field, they form a single optical element of larger effective thickness and improved efficiency and reduced background from undiffracted radiation. This allows us both to use zone plates of moderate outermost zone width at energies of 30 keV and above, as well as to increase the efficiency of zone plates with small outermost zone widths particularly for the energy range of 6-15 keV.
ChemInform Abstract: Concepts in Heterogeneous Catalysis (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Miniaturized on-line proteolysis-packed capillary LC-MS for peptide mapping of lactate dehydrogenase (2003)

Miniaturized on-line proteolysis-packed capillary LC-MS for peptide mapping of lactate dehydrogenase
A Transform-Domain Decoding Algorithm for Reed-Solomon Codes (2006)

This paper presents a Reed-Solomon decoding algorithm based on the Euclidean algorithm. The algorithm is conceptually simple and operates only in transform domain. The spectrum of the codeword is directly computed without the explicit knowledge of error-locator and error-evaluator polynomials; the Chien search and the Forney algorithm are not necessary
Autonomic fine-grained migration and replication of component-based applications across multi-clouds (2015)

Although migration and replication of applications in a distributed environment have been discussed by many researchers, the implementations of these features are rarely focused when deployed in the Cloud. Distributed computing started with the cluster, evolved into the grid and now in the era of Cloud computing, where services are provided on demand and used with a pay-as-you-go style. In the Cloud, the enterprises usually have to migrate or replicate partly or fully their services because of economical or disaster preventing reasons. Because the cost of copying/moving the whole virtual machines is too high due to their big size, the replication/migration at application level is a possible approach. This work proposes an autonomically fine-grained framework for migrating/replicating the service components on the Clouds, which is a multi-cloud distributed deployment platform. Our proposed framework ensures the high availability and scalability of services, and complies with the service-oriented architecture. Our experiments conducted in real scenarios of elastic demands show that the proposed fine-grained migration/replication is more efficient than the coarse-grained ones when an autonomic system responds to fluctuation of webapp's workload.
Three‐dimensional sonographic calculation of the volume of intracranial structures in growth‐restricted and appropriate‐for‐gestational age fetuses (2009)

IUGR fetuses show differences in the volume of intracranial structures compared with AGA fetuses, with the largest difference found in the frontal region. These differences might be explained by in-utero processes of neural reorganization induced by chronic hypoxia.
Simplified Models for Accelerated Structural Prediction of Conjugated Semiconducting Polymers (2017)

We perform molecular dynamics simulations of poly(benzodithiophene-thienopyrrolodione) (BDT-TPD) oligomers in order to evaluate the accuracy with which unoptimized molecular models can predict experimentally characterized morphologies. The predicted morphologies are characterized using simulated grazing-incidence X-ray scattering (GIXS) and compared to the experimental scattering patterns. We find that approximating the aromatic rings in BDT-TPD with rigid bodies, rather than combinations of bond, angle, and dihedral constraints, results in 14% lower computational cost and provides nearly equivalent structural predictions compared to the flexible model case. The predicted glass transition temperature of BDT-TPD (410 ± 32 K) is found to be in agreement with experiments. Predicted morphologies demonstrate short-range structural order due to stacking of the chain backbones (π–π stacking around 3.9 Å), and long-range spatial correlations due to the self-organization of backbone stacks into “ribbons” (lamellar ordering around 20.9 Å), representing the best-to-date computational predictions of structure of complex conjugated oligomers. We find that expensive simulated annealing schedules are not needed to predict experimental structures here, with instantaneous quenches providing nearly equivalent predictions at a fraction of the computational cost of annealing. We therefore suggest utilizing rigid bodies and fast cooling schedules for high-throughput screening studies of semiflexible polymers and oligomers to utilize their significant computational benefits where appropriate.
Iron‐Nitrosyl Bond Configuration in Nitrosyl‐Hemoproteins: A Comparative EPR Study of Hemoglobin A and Hemoglobin Kansas (1976)

Abstract Hemoglobin A and hemoglobin Kansas can exist in alternative forms in which the affinity of heme iron for NO is mediated either by pH or the presence of allosteric modifiers. In this study, we show that the superhyperfine (SHF) pattern observed in the EPR which arises from the heme iron‐NO complex can be correlated with a change in the affinity of the ligated tetrameric protein for NO. When a combination three‐line and nine‐line SHF pattern is observed, the nitrosyl hemoprotein is in a low affinity form while a nine‐line pattern alone is an expression of high affinity. A theory is presented relating SHF patterns to a molecular orbital picture of the nitrosyl heme complex. It is suggested that the change of SHF pattern correlated with an alteration of the affinity state of ligated hemoglobin is related to a structural change of the proximal imidazole ligand to the heme.
Supplementary Figure S5 from Development and Validation of Machine Learning–based Model for the Prediction of Malignancy in Multiple Pulmonary Nodules: Analysis from Multicentric Cohorts (2023)

&lt;p&gt;The generalizability of PKU-M model in prediction of SPNs&lt;/p&gt;
Expanded Utility of the Native Chemical Ligation Reaction (2004)

The post-genomic era heralds a multitude of challenges for chemists and biologists alike, with the study of protein functions at the heart of much research. The elucidation of protein structure, localization, stability, post-translational modifications, and protein interactions will steadily unveil the role of each protein and its associated biological function in the cell. The push to develop new technologies has necessitated the integration of various disciplines in science. Consequently, the role of chemistry has never been so profound in the study of biological processes. By combining the strengths of recombinant DNA technology, protein splicing, organic chemistry, and the chemoselective chemistry of native chemical ligation, various strategies have been successfully developed and applied to chemoselectively label proteins, both in vitro and in live cells, with biotin, fluorescent, and other small molecule probes. The site-specific incorporation of molecular entities with unique chemical functionalities in proteins has many potential applications in chemical and biological studies of proteins. In this article, we highlight recent progress of these strategies in several areas related to proteomics and chemical biology, namely, in vitro and in vivo protein biotinylation, protein microarray technologies for large-scale protein analysis, and live-cell bioimaging.
Monitoring Breast Cancer Tumor Response At Different Timepoints During Pre-Surgical Chemotherapy with Diffuse Optical Spectroscopic Imaging (2010)

Diffuse Optical Spectroscopic Imaging (DOSI) provides non-invasive functional biomarkers that correlate with final pathological response to pre-surgical (neoadjuvant) chemotherapy in breast cancer patients that are measured at various timepoints throughout the therapy.
Frame Synchronization for Gaussian Channels (1987)

The problem of locating a periodically inserted frame synchronization pattern in random data for a <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</tex> -ary digital communication system operating over the additive white Gaussian noise channel is considered. The optimum maximum-likelihood decision rule, high signal-to-noise approximate maximum likelihood decision rule, and ordinary correlation decision rule for frame synchronization are derived for both coherent and noncoherent phase demodulation. A general lower bound on synchronization probability is derived for the coherent correlation rule. Monte Carlo computer simulations of all three decision rules, along with evaluations of the lower bound for the coherent correlation rule, were performed for the coherent MPSK, coherent, and noncoherent <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</tex> ary orthogonal, and 16 QAM signaling schemes. These results show that in each case the high signal-to-noise maximum-likelihood rules have a performance nearly equal to that of the maximum-likelihood rules over a wide range of practically interesting signal-to-noise ratios (SNR's). These high SNR decision rules also provide significant performance improvement over the simple correlation rules. Moreover, they are much simpler to implement than the maximum-likelihood decision rules and, in fact, are no more complex than the correlation rules.
Constitutive and induced phosphorylation of the alpha - and beta -chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions. (1990)

We sought to determine whether the activation event which renders the CD11/CD18 leukocyte integrin/Leu-CAM glycoproteins capable of promoting cell to cell adhesion was associated with the induced posttranslational modification of phosphorylation. In neutrophils, two species of alpha-chains, a predominant CD11b 165-kDa subunit and a minor 150-kDa CD11c subunit were found to be constitutively phosphorylated. However, the 95-kDa CD18 common beta-chain was not phosphorylated in resting cells but became strongly phosphorylated in cells incubated with PMA. The beta-chain was phosphorylated in a dose-related manner within 1 min of the addition of PMA, reached maximal intensity between 4 to 10 min, and remained fully phosphorylated at 30 min. The similarities of the kinetics of homotypic aggregation induced by PMA to the time course of phosphorylation suggest that phosporylation may be relevant to at least this type of Leu-CAM-dependent adhesion. In contrast, in the presence of FMLP which induces aggregation with different kinetics than PMA, no phosphorylation of the common beta-chain was observed over a time interval of from 30 s to 10 min further emphasizing the apparent differences in the two modes of activation to an adhesive state. The phosphorylated species on neutrophils were readily detected by immunoprecipitation with each CD18 mAb and most but not all CD11b mAb which otherwise precipitated 125I-labeled CD11b species suggesting that the CD11b alpha-chain labelled with 32P may differ slightly from the 125I-labeled species in terms of its recognition by certain CD11b mAb. In mononuclear cells, similar constitutive phosphorylation of the CD11a and CD11c alpha-chains was observed that remained unchanged in the presence of either FMLP or PMA. As was demonstrated in neutrophils, phosphorylation of the CD18 beta-chains of mononuclear cells was not constitutive but was induced in the presence of PMA and not FMLP. Taken together these data suggest the existence of specific recognition sites on beta-chains for a regulatory kinase-phosphatase system.
Gut Microbiota: An Integral Moderator in Health and Disease (2018)

The gut microbiota, as the main member in gut microecology, is an essential mediator in health and disease. The gut microbiota interacts with various organs and systems in the body, including brain, lung, liver, bone, cardiovascular system, and others. Microbiota-derived metabolites such as the short chain fatty acid (SCFA) butyrate are primary signals, which link the gut microbiota and physiology. Recently, the gut microbiota has been identified as the origin of a number of diseases by influencing the related cell signaling pathways such as WNT/beta-catenin pathway in colorectal cancer and T cell receptor signaling in the central nervous system. Moreover, several microRNAs participate in signaling networks through the intervention of the gut microbiota. The interaction between the gut microbiota and miRNAs plays a crucial role in vascular dysfunction and hepatocellular carcinoma (HCC). In this review, we will report and discuss recent findings about the crosstalk between the gut microbiota and physical organs and how the gut microbiota and miRNAs regulate each other while influencing the host via genes, proteins, or metabolites.
Abstract 5164: Mechanosensor MYL9 regulates cancer cell malignancy in gastrointestinal tumors (2018)

Abstract Although the stiffness of tissues likely is involved in the malignant behavior of tumors, it remains to be clarified which molecules control the nature, how it is involved in the invasiveness of tumors, or whether any marker is available for the prediction of cancer patient prognosis. In the present study, we studied the role of Myl9, a non-muscle-type, myosin light chain by the experiment in vitro, and assessed the usefulness in the stratification of patients in vivo as the precision medicine. Given that Myl9 is involved in the contraction of cell skeleton, cell hardness, and alterations of cell morphology in various tissues, we first examined whether the expression of the Myl9 is associated with the clinical status of tumors by immunohistochemistry. The results of 45 cases with colon cancer and pancreatic cancer indicated that the increased expression of Myl9 is associated significantly with a reduced provability of overall survival and disease-free survival of those cancers. Moreover, we noted the differential expression of Myl9 in epithelial cancer cells and mesenchymal fibroblasts, i.e., the accumulation of Myl9 staining in cell nuclei of fibroblasts. The experiment of 3-dimensional culture with cancer cells and fibroblasts confirmed the results. Furthermore, we investigated whether Myl9 overexpression is involved in the biologic behavior of gastrointestinal cancer cells. The results showed that the rentiviral-mediated overexpression of Myl9 resulted in an increase of cell proliferation and invasion as well as tumorigenicity in mice. The present study indicates that Myl9 protein can play a fundamental role in the malignant behaviors of gastrointestinal cancer cells. Citation Format: Masamitsu Konno, Kiminori Yanagisawa, Katsunori Matsushita, Ayumu Asai, Jun Koseki, Michiya Matsusaki, Shinji Deguchi, Yuichiro Doki, Masaki Mori, Hideshi Ishii. Mechanosensor MYL9 regulates cancer cell malignancy in gastrointestinal tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5164.
Molecular Typing of Epizootic Hemorrhagic Disease Virus Serotypes by One-Step Multiplex RT-PCR (2014)

Epizootic hemorrhagic disease virus (EHDV) causes a highly infectious noncontagious hemorrhagic disease in wild and captive deer (Cervidae) populations in the US. Although rapid and accurate identification of the disease is important, identification of the serotype is equally important for understanding the epidemiology of the disease in white-tailed deer (Odocoileus virginianus) populations. We developed a one-step multiplex reverse transcriptase PCR assay for rapid differentiation and identification of EHDV serotypes 1, 2, and 6 in cell culture and clinical samples by targeting the viral gene segment 2 (L2) that encodes for the structural protein VP2. From 2009 to 2012, 427 clinical samples including tissue and blood (in ethylenediaminetetraacetic acid) from white-tailed deer, found EHDV positive by real-time PCR, were used to evaluate this subtyping assay. Eighteen percent of the positive samples tested were EHDV-1, 59% were EHDV-2, and 21% were EHDV-6; 2% of the samples were positive for more than one subtype, indicating mixed infection. This assay provides a rapid, sensitive, specific diagnostic tool for differentiation and identification of EHDV serotypes in field samples and virus isolates.
Supplementary Figure 2 from Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer (2023)

&lt;p&gt;PDF file - 63K, High dietary vitamin D decreases diarrhea in H. bilis-infected Smad3-/- mice.&lt;/p&gt;
A Microdosimetric Algorithm for Electron Point Kernel Data: 1. Monoenergetic-Electron Sources (1996)

Journal Article A Microdosimetric Algorithm for Electron Point Kernel Data: 1. Monoenergetic-Electron Sources Get access E.-H. Kim, E.-H. Kim Search for other works by this author on: Oxford Academic PubMed Google Scholar W.E. Bolch, W.E. Bolch Search for other works by this author on: Oxford Academic PubMed Google Scholar W.D. Reece, W.D. Reece Search for other works by this author on: Oxford Academic PubMed Google Scholar J.W. Poston Sr. J.W. Poston Sr. Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 63, Issue 4, 1 February 1996, Pages 245–252, https://doi.org/10.1093/oxfordjournals.rpd.a031536 Published: 01 February 1996
Significantly enhanced photoluminescence and thermal stability of La3Si8N11O4:Ce3+,Tb3+via the Ce3+ → Tb3+ energy transfer: a blue-green phosphor for ultraviolet LEDs (2018)

A series of Ce<sup>3+</sup>-, Tb<sup>3+</sup>- and Ce<sup>3+</sup>/Tb<sup>3+</sup>-doped La<sub>3</sub>Si<sub>8</sub>N<sub>11</sub>O<sub>4</sub> phosphors were synthesized by gas-pressure sintering (GPS). The energy transfer between Ce<sup>3+</sup> and Tb<sup>3+</sup> occurred in the co-doped samples, leading to a tunable emission color from blue to green under the 360 nm excitation. The energy transfer mechanism was controlled by the dipole-dipole interaction. The Ce<sup>3+</sup>/Tb<sup>3+</sup> co-doped sample had an external quantum efficiency of 46.7%, about 5.6 times higher than the Tb-doped La<sub>3</sub>Si<sub>8</sub>N<sub>11</sub>O<sub>4</sub> phosphor (8.3%). The thermal quenching of the Tb<sup>3+</sup> emission in La<sub>3</sub>Si<sub>8</sub>N<sub>11</sub>O<sub>4</sub>:Tb,Ce was greatly reduced from 74 to 30% at 250 °C, owing to the energy transfer from Ce<sup>3+</sup> to Tb<sup>3+</sup>. The blue-green La<sub>3</sub>Si<sub>8</sub>N<sub>11</sub>O<sub>4</sub>:0.01Ce,0.05Tb phosphor was testified to fabricate a warm white LED that showed a high color rendering index of 90.2 and a correlated color temperature of 3570 K. The results suggested that the co-doped La<sub>3</sub>Si<sub>8</sub>N<sub>11</sub>O<sub>4</sub>:Ce,Tb phosphor could be a potential blue-green down-conversion luminescent material for use in UV-LED pumped wLEDs.
MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression (2016)

Positive associations observed between MED12 and ERα, ERβ immunohistochemical expression suggest a biological interplay between the proteins. The lack of significant association of MED12 mutation with ER protein expression indicates a need to further explore the functional impact of MED12 mutations on the ER signalling pathway in breast fibroepithelial lesions.
Resection of liver metastases from colorectal cancer (1996)

Female patients and those with peroperative CEA values higher than 20 ng/ml have a better chance of survival following hepatic resection. Cancer of the right colon has a greater tendency for hepatic recurrence than that of the left colon.