gebhart/patrepeval huggingface dataset:
L'initiation de la synthèse des protéines chez les eucaryotes. (2000)

e declenchement de la synthese des proteines chez les eucaryotes procede selon trois mecanismes distincts, qui peuvent etre complementaires. Ce sont : (1) le balayage des ribosomes de la coiffe 5’ au codon d’initiation, majoritairement un AUG present dans un contexte de type A/GCCAUGG ; (2) le recrutement direct, et en position interne, des ribosomes par un element genetique appele IRES (internal ribosome entry segment), et (3) le shunt (courtcircuit) au cours duquel les ribosomes reconnaissent le 5’, puis sont transferes au niveau du codon initiateur. La decouverte des IRES dans les ARNm viraux et cellulaires, grâce aux travaux originaux sur les picornavirus, a permis de mettre au point des vecteurs retroviraux polycistroniques ayant plusieurs IRES. Ces vecteurs derives du virus de la leucemie murine, MuLV, et appeles MLVIRES, possedent des proprietes remarquables, a savoir des titres viraux tres eleves et la possibilite de transferer plusieurs genes dans un grand nombre de cellules differentes et d’assurer leur expression coordonnee. Ces vecteurs retroviraux MLVIRES pourraient donc etre utiles pour un transfert de genes d’interet therapeutique, particulierement en cancerologie. 77 L’initiation de la synthese des proteines chez les eucaryotes
Defending against sensor-sniffing attacks on mobile phones (2009)

Modern mobile phones possess three types of capabilities: computing, communication, and sensing. While these capabilities enable a variety of novel applications, they also raise serious privacy concerns. We explore the vulnerability where attackers snoop on users by sniffing on their mobile phone sensors, such as the microphone, camera, and GPS receiver. We show that current mobile phone platforms inadequately protect their users from this threat. To provide better privacy for mobile phone users, we analyze desirable uses of these sensors and discuss the properties of good privacy protection solutions. Then, we propose a general framework for such solutions and discuss various possible approaches to implement the framework's components.
Phase map retrieval in digital holography: avoiding the under-sampling effect by a lateral shear approach (2008)

In Digital Holography (DH) the numerical reconstruction of the whole wavefront refracted or reflected by a sample object allows one to extract the wrapped phase map mod, 2&pi;. In fact, since the hologram is coded numerically as a digitized image, both the wavefront amplitude and phase can be reconstructed simultaneously to provide amplitude and phase contrast imaging. The resolution in the image plane is the reconstruction pixel size that depends on wavelength, reconstruction distance and the size of the CCD recording area. Efforts to improve the resolution of DH reconstructions have been accomplished, following various strategies: increasing of the hologram aperture by moving the camera in different positions or even by using synthetic aperture approaches, using a diffraction grating to record digital holograms with a wider solid angle in the object beam, or using multiple sources and/or multiple acquisitions. Although all of these methods allow one to increase the spatial resolution, one more complication exists concerning the loss of resolution that occurs in the usual DH reconstruction approaches. It can occur that the reconstructed wrapped phase map in the image plane is undersampled because of the limited pixel size which limits the spatial bandwidth of the reconstructed image. In such a case the phase distribution cannot be retrieved correctly by the usual unwrapping procedures. We show that the use of the digital Lateral-Shearing Interferometry (LSI) approach in DH provides the correct reconstruction of the phase map in the image plane, even in extreme cases where the phase profile changes very rapidly. We demonstrate the effectiveness of the method in a particular case where the profile of a highly curved silicon micro-electromechanical system membrane has to be reconstructed.
Epidemiology and molecular characterization of vancomycin resistant Enterococci isolates in India (2007)

Little attention has been paid to the problem of the spread of vancomycin resistant enterococci (VRE) in India. Between August 2002 to March 2003, faecal and urine samples of patients from various wards of the Postgraduate Institute of Medical Education and Research, Chandigarh, India, were screened for vancomycin resistance. 36 VRE were isolated (18 Enterococcus gallinarum, 9 E. casseliflavus, 7 E. faecium and 2 E. faecalis). These isolates were characterized as low-, moderate- and high-level resistant strains by phenotypic as well as genotypic methods such as minimum inhibitory concentration determination, polymerase chain reaction assays, sequencing of PCR products and multiple sequence alignment of van genes. Correlations established between these results and the vancomycin resistance markers were designated as vanA (783 bp), vanB (635 bp), vanC1 (822 bp) and vanC2 (484 bp) according to the findings of earlier workers as well as comparison with existing databases. Prolonged hospital stay and vancomycin were important risk factors for both VRE UTI and colonization. Renal dialysis, renal failure, prior aminoglycoside and third generation cephalosporin were the other significant factors for VRE UTI. The study also highlights the importance of screening for VRE in clinical samples and recommends the institution of control measures to prevent the further spread of VRE.
Abnormalities of iron metabolism and erythropoiesis in vitamin E- deficient rabbits (1978)

Rabbits fed a vitamin E-deficient diet developed severe muscular dystrophy in 3–4 wk, but they did not become anemic. Nevertheless, reticulocyte counts increased in deficient rabbits (3.2%) compared to control rabbits (0.9%), and erythroid hyperplasia was evident in the bone marrow. Comparing deficient rabbits to controls, the plasma iron concentration was lower (134.4 versus 206.6 microgram/dl); the TIBC was higher (335.9 versus 228.3 microgram/dl); the whole blood protoporphyrin concentration was higher (131.6 versus 81.7 microgram/dl); and the total iron content was lower in spleen (71 versus 153 microgram), higher in skeletal muscle (4956 versus 3054 microgram), and unchanged in bone marrow, liver, and heart. Studies of iron absorption and excretion using 59Fe showed no abnormalities in deficient rabbits. There were abnormalities of ferrokinetics, however. The half-time of disappearance of 59Fe was shorter (100.6 versus 169.4 min), the plasma iron turnover was greater (1.25 versus 0.95 mg/dl blood/day), and the reappearance of 59Fe in circulating erythrocytes at day 9 was greater (77.2% versus 57.2%) in deficient rabbits. Anemia induced by phlebotomy accentuated the abnormal iron metabolism of deficient rabbits, and the animals were unable to correct the anemia. These findings show that vitamin E deficiency in rabbits causes abnormal erythropoiesis associated with abnormal iron metabolism and sequestration of iron in skeletal muscle.
Sectors, Beams and Environmental Impact on the Performance of Commercial 5G mmWave Cells: an Empirical Study (2021)

While the performance of mmWave links has been thoroughly investigated by simulations or testbeds, the behavior of this technology in real-world commercial setups has not yet been thoroughly documented. In this paper, we address this gap and present the results of an empirical study to determine the actual performance of a commercial 5G mmWave cell through on-field measurements. We evaluate the signal and beam coverage map of an operational network as well as the end-to-end communication performance of a 5G mmWave connection, considering various scenarios, including human body blockage effects, foliage-caused and rain-induced attenuation, and water surface effects. To the best of our knowledge, this paper is the first to report on a commercial deployment while not treating the radio as a black box. Measurement results are compared with 3GPP's statistical channel models for mmWave to check the possible gaps between simulated and actual performance. This measurement analysis provides valuable information for researchers and 5G verticals to fully understand how a 5G mmWave commercial access network operates in real-world, under various operational conditions, with buildings, humans, trees, water surfaces, etc.
JPEG standard uniform quantization error modeling with applications to sequential and progressive operation modes (2001)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
concept Multi-tasking by the p75 neurotrophin receptor: sortilin things out? (2004)

Signalling by the p75 neurotrophin receptor has been implicated in diverse neuronal responses, including increased differentiation or survival, inhibition of regeneration, and initiation of apoptotic cell death. These numerous roles are matched by, but are not yet correlated with, a multiplicity of extracellular ligands and intracellular interactors. Membrane proteins such as sortilin, a member of the Vps10p family of sorting receptors, and the glycosylphosphatidylinositol-linked Nogo receptor (NgR) and the associated adaptor lingo 1 have recently been added to the list of p75-interacting modulators. Other studies have described intramembranal cleavage of p75 and the potential nuclear targeting of cleavage fragments or of the complete receptor after it has been internalized into a putative signalling endosome. These findings suggest that some of the diversity in p75 activities might be due to differential subcellular localization and transport of p75 receptor complexes. We therefore argue that cell-biology-driven approaches are now required to make sense of p75 signalling.
Interaction of (−)-Epigallocatechin Gallate and Deoxyosones Blocking the Subsequent Maillard Reaction and Improving the Yield of N-(1-Deoxy-d-xylulos-1-yl)alanine (2020)

(-)-Epigallocatechin gallate (EGCG) had a significant effect on Maillard reaction intermediate formation in the xylose/alanine model system. A trapping effect of EGCG on the reactive deoxyosones was observed to change the reaction pathways. The rate constant of Amadori rearrangement product (ARP) conversion to deoxyosones was decreased with EGCG addition, indicating an inhibition of ARP degradation. Dehydration improved the ARP formation during the thermal reaction and synergistically improved the yield of ARP with the EGCG trapping effect on the deoxyosones. Additionally, EGCG decreased the activation energy for the conversion of xylose/alanine to ARP (from 77.8 to 62.8 kJ/mol) and in turn accelerated the ARP formation. The effect of EGCG was further facilitated at the optimal conditions of 90 °C, at pH 7.5, and a molar ratio of xylose to alanine of 2:1, which improved the yield of ARP (<i>N</i>-(1-deoxy-d-xylulos-1-yl)alanine) from 2 to 95%.
High-level transgene expression in induced pluripotent stem cell–derived megakaryocytes: correction of Glanzmann thrombasthenia (2013)

Megakaryocyte-specific transgene expression in patient-derived induced pluripotent stem cells (iPSCs) offers a new approach to study and potentially treat disorders affecting megakaryocytes and platelets. By using a Gp1ba promoter, we developed a strategy for achieving a high level of protein expression in human megakaryocytes. The feasibility of this approach was demonstrated in iPSCs derived from two patients with Glanzmann thrombasthenia (GT), an inherited platelet disorder caused by mutations in integrin αIIbβ3. Hemizygous insertion of Gp1ba promoter-driven human αIIb complementary DNA into the AAVS1 locus of iPSCs led to high αIIb messenger RNA and protein expression and correction of surface αIIbβ3 in megakaryocytes. Agonist stimulation of these cells displayed recovery of integrin αIIbβ3 activation. Our findings demonstrate a novel approach to studying human megakaryocyte biology as well as functional correction of the GT defect, offering a potential therapeutic strategy for patients with diseases that affect platelet function.
Matrix norm based method for recovery of high contrast and sparse objects in microwave imaging (2017)

The application of matrix-norm-minimization based compressive sensing (CS) for inverse scattering problems is discussed. In particular, two CS - based techniques are developed and compared to solve the imaging problem in a 2D sparse domain. The two proposed methods are (i) mix-norm constrained minimization and (ii) proposed joint minimization of a matrix rank and element-wise sparsity of the matrix. The problem is formulated as a linear system in contrast source as an unknown variable. A set of numerical simulations is presented to convey advantages and limitations of the considered methods.
"Bad breath": presenting manifestation of anaerobic pulmonary infection. (1975)

Three patients are described in whom a putrid breath odor was the only or fist manifestation of anaerobic infection of the lung. Fever, productive cough, and pleuritic pain, common findings in anaerobic pulmonary infection, were not initally present. "Bad breath" may be an early due to the presence of anaerobic pulmonary infection.
Collection of published 5S and 5.8S ribosomal RNA sequences (1983)

The 1981 collection (1) of mature 5S and 5.8S RNA sequences Is updated.The sequences reported are based on actual sequence determinations and not on the basis of oligonucleotide catalogues.Some of the earlier published oligonucleotide catalogues are given in reference 2. For a summary of the possible structure and function of the ribosomal 5S and 5.8S RNAs the reader is refered to references 3-8.For this year the collection of 5S RNA sequences will be presented according to the recently proposed structure model of De Wachter, Chen and Vandenberghe (8), even though we realize that these structures, being deduced by a comparative approach, have not been experimentally proven to be correct.It may well be that next years sequences will be presented in the previous (1) form or in alignment with another secondary structural model.We would also like to thank those colleagues who have sent us their pre-or reprints on small ribosomal RNA sequences in 1982, and who have pointed out several mistakes in our previous collection. SEQUENCE ALIGNMENTThe procedure followed to align the 5S RNA has been described previously (8).It is based on the presence of marker residues and sequences that are conserved, with very few exceptions, in all 5S RNAs.Examples of such markers are YRC 35 , CRU 4g , AARC ?4 ,
Synthesis and Biological Evaluation of Some Novel Isoxazole Derivatives (2016)

The reaction of 5‐amino‐3‐methylisoxazole ( 1 ) with formalin and secondary amines gave the corresponding Mannich bases 3 , 4 , 5 , 6 . Alkylation of isoxazole derivative 1 with Mannich bases hydrochloride gave unsubstituted isoxazolo[5,4‐ b ]pyridine derivatives 8a , 8b via alkylation at position 4. Moreover, coupling reaction of 1 with different diazonium salts gave the corresponding mono and bisazo dyes of isoxazole derivative. The newly synthesized compounds were screened for their antitumor activity compared with 5‐fluorouracil as a well‐known cytotoxic agent using Ehrlich ascites carcinoma cells. Interestingly, the obtained results showed clearly that compounds 3 , 15 , 8b , 4 , 8a , and 5 exhibited high antitumor activity than 5‐fluorouracil.
A cascaded converter-based StatCom with energy storage (2003)

Due to their advantages in high power applications, multi-level converters have been introduced to flexible AC transmission systems (FACTS) to enhance power transmission system operation. Although several multi-level StatCom topologies have been proposed to verify the high performance of multi-level converters used in reactive power compensation, they are not capable of controlling active power flow. To make multi-level converters more flexible and effective for active power flow control, energy storage systems, such as flywheels and batteries are incorporated into StatComs. In this paper, battery energy storage systems (BESS) are incorporated into a cascaded converter-based StatCom to implement both active and reactive power flow control using a PQ-decoupled PI control strategy. Furthermore, the dynamics of the integrated system in damping power oscillations are studied using an electromagnetic transient program PSCAD/EMTDC. Simulation results are provided to verify the feasibility and practicality of these ideas.
NUMERICAL ANALYSIS OF A MODEL WALL REINFORCED WITH POLYPROPYLENE GEOGRIDS (2000)

The capability and reliability of numerical codes to describe the behaviour of reinforced walls are validated through the experimental results of a geogrid reinforced model wall
Secure Identity Authentication of Community Medical Internet of Things (2019)

In the community medical Internet of Things (IoT) environment, there exist a large number of device nodes, network nodes and user nodes which form a heterogeneous network. In order to ensure smooth data exchange, some gateway nodes are adopted to connect different network spaces. Therefore, how to identify and authenticate the identities of heterogeneous nodes is an urgent problem to be solved. In this paper, we start with node security identity authentication, make uses of the mechanism of elliptic curve encryption algorithm signature and session key symmetric encryption, design an efficient community medical IoT node secure two-way identity authentication method, and propose a secure and reliable update mechanism for the update of authentication keys and session keys. These measures can effectively ensure the legality of nodes and communication security in the community medical IoT system. Through the analysis and comparison of experimental performance, this scheme is more suitable for the scene of community medical Internet of Things.
Chiral Electrode Behaviors of Magnetoelectrodeposited Ag films for Amino Acids (2008)

Chiral aspects were investigated in the Ag films electrodeposited under magnetic fields of 2 and 3 T perpendicular to the electrode surface. The films were used as modified electrodes, and cyclic voltammograms were examined for the electrochemical oxidation of cysteine and histidine. In both cases, the chiral aspects were observed as the peak current difference between the enantiomers, and the chirality depended on the polarity of the magnetic field during the electrodeposition. The formation of such chiral films is discussed in connection with the micro-MHD effect.
Self-aligned &#x03BC;Trench phase-change memory cell architecture for 90nm technology and beyond (2007)

A novel self-aligned muTrench-based cell architecture for phase change memory (PCM) process is presented. The low-programming current and the good dimensional control of the sub-lithographic features achieved with the muTrench structure are combined with a self-aligned patterning strategy that simplify the integration process in term of alignment tolerances and of number of critical masks. The proposed architecture has been integrated in a 90 nm 128 Mb vehicle with programming currents of 300 muA and good distributions, demonstrating its suitability for the production of high-density PCM arrays at 90 nm and beyond.
Ligand Effects on Optical Properties of Small Gold Clusters: A TDDFT Study (2012)

Ligand influence on the excited state structure of small neutral gold clusters (Au2 and Au4) has been investigated using Time Dependent Density Functional Theory. We study in detail the absorption profile of bare and ligated small gold clusters in solution modeled with Polarizable Continuum Model. Performance of CAM-B3LYP and TPSS DFT functionals combined with TZVP basis set has been assessed. We found that ligands substantially modify the excited state structure of clusters by eliminating low-lying optically inactive excited states. Depending on the ligand environment, the cluster may gain significant fluorescence efficiency. Our results suggest that small gold clusters ligated with amines will have better fluorescence potential compared to those ligated with phosphine or thiol ligands, in agreement with preliminary experimental data. TPSS fails to describe excited state structure of ligated clusters due to spurious charge-transfer states, thus highlighting the necessity of choosing appropriate quantum-chemistry model for correct excited state description.
Hypertensive Disorders in Pregnancy (2014)

This course is part of a project that aims to reduce maternal mortality in Sub-Saharan Africa by providing specialty training in Obstetrics and Gynecology. This training will be provided in a partnership between high-income and low- and middle-income countries (LMIC). We hope that you find the course useful in whatever role you play in the reduction of maternal mortality, and that together we will find a way to sustainably improve the lives women, children, and the people who care for them in Sub Saharan Africa. This course is offered periodically as an instructor-facilitated interactive online course through Elevate Health at http://www.elevatehealth.eu/obgyn2014. It was first offered June 22, 2014 - June 27, 2014.
Recent developments of proton‐transfer reaction mass spectrometry (PTR‐MS) and its applications in medical research (2012)

Proton-transfer reaction mass spectrometry (PTR-MS) allows for real-time, on-line determination of absolute concentrations of volatile organic compounds (VOCs) with a high sensitivity and low detection limits (in the pptv range). The technique utilizes H₃O⁺ ions for proton-transfer reactions with many common VOCs while having little to no reaction with any constituents commonly present in air. Over the past decades, research has greatly improved the applications and instrumental design of PTR-MS. In this article, we give an overview of the development of PTR-MS in recent years and its application in medical research. The theory of PTR-MS and various methods for discriminating isobaric VOCs are also described. We also show several specialized designs of sample inlet system, some of those may make PTR-MS suitable for the detection of aqueous solution and/or non-volatile samples.
Visual and Postural Motion-Evoked Dizziness Symptoms Are Predominant in Vestibular Migraine Patients (2017)

Chronic recurrent dizziness symptoms, rather than internal or external vertigo, are predominant in our VM patients. Recurrent brief dizziness attacks induced upon routine visual and/or postural motion, longstanding symptoms with limited response to vestibular suppressants, and precipitation by typical migraine triggers are suggestive of VM.
Supplementary Table S2 from Biomarker Data from the Phase III KATHERINE Study of Adjuvant T-DM1 versus Trastuzumab for Residual Invasive Disease after Neoadjuvant Therapy for HER2-Positive Breast Cancer (2023)

&lt;p&gt;Prognostic value for IDFS by treatment arm of biomarker gene expression levels (&gt;median vs. ≤median and continuous) in post-NAT surgical RNA-evaluable tissue samples. Analysis is adjusted for tumor content. One sample could not be included because there was insufficient information on tumor content.&lt;/p&gt;