gebhart/patrepeval huggingface dataset:
An Elastic Autonomous Self‐Healing Capacitive Sensor Based on a Dynamic Dual Crosslinked Chemical System (2018)

Adopting self-healing, robust, and stretchable materials is a promising method to enable next-generation wearable electronic devices, touch screens, and soft robotics. Both elasticity and self-healing are important qualities for substrate materials as they comprise the majority of device components. However, most autonomous self-healing materials reported to date have poor elastic properties, i.e., they possess only modest mechanical strength and recoverability. Here, a substrate material designed is reported based on a combination of dynamic metal-coordinated bonds (β-diketone-europium interaction) and hydrogen bonds together in a multiphase separated network. Importantly, this material is able to undergo self-healing and exhibits excellent elasticity. The polymer network forms a microphase-separated structure and exhibits a high stress at break (≈1.8 MPa) and high fracture strain (≈900%). Additionally, it is observed that the substrate can achieve up to 98% self-healing efficiency after 48 h at 25 °C, without the need of any external stimuli. A stretchable and self-healable dielectric layer is fabricated with a dual-dynamic bonding polymer system and self-healable conductive layers are created using polymer as a matrix for a silver composite. These materials are employed to prepare capacitive sensors to demonstrate a stretchable and self-healable touch pad.
Hydraulic Fracturing for Control of Sand Production and Asphaltene Deposition in Deep Hot Wells (1996)

Abstract The North of Monagas giant field in Venezuela has been produced since the late 80-s. Depth ranges from 12000 to 20000 ft (3,600 to 6,000 m). Wells in the field have experienced early in the production cycle both problems of sand production and asphaltene flocculation. A multidisciplinary team was created to define ways to optimize production from the field. The paper first addresses the methodology used to identify the source of the sanding problem, including extensive mechanical analysis of the formation, with tri-axial testing and sanding critical flow gradient analysis. The effectiveness of the initial strategies of optimization of choke size, and selection of perforated intervals and gun sizes is evaluated. The onset of asphaltene deposition was analyzed, and it was determined that most occurring problems were related to drilling and production practices. To solve both problems, by modifying pressure drop and flow profiles, a hydraulic fracturing strategy was implemented in the field. Special care was given to the particular well conditions (close-by dual tubing completion, with potential risk of communication, thick and multi-layered geometry), in addition to expected high treating pressures and sensitivity of formation fluids to thermal shocks. A detailed pre- and post-fracturing well testing procedure was adopted which allows for an optimization of the fracture length, and comparison of results with predictions. Prior to the main fracture, calibration treatments were performed; calculated fracture heights were compared to the ones determined from temperature logs. A new technique to determine permeability from mini-fracs using the theory of impulse testing was also applied. Finally, production logging after the frac and a build-up were used to assess the validity of the predictions. Introduction The giant North of Monagas field lies in the East of Venezuela, in an area of over 400 km2 (Fig. 1). Its structure is an asymmetric anticline, with the Naricual formation (late Oligocene) being the most important feature, and thickness of over than 1500 ft, at depths between 12000 and 20000 ft (3.6 km to 6 km). The field was discovered in the 1980's. Despite high reservoir pressures, several wells have experienced severe sanding problems, combined with asphaltene deposition in the downhole tubulars. In addition to production losses, the frequency of well intervention to clean up downhole flow obstructions (via workover, snubbing or coiled tubing), and the complexity of working in wells with dual completions has created a major challenge. Another problem has been in the erosion of surface equipment, due to sand flow. In order to provide viable long-term solutions to both problems (sand production and asphaltene), a work group between Corpoven and external laboratories to identify the cause of the production behaviour, and implement efficiently the techniques, with proper evaluation. P. 449
Alveolar rhabdomyosarcoma–associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression (2013)

Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the paired box 3-forkhead box protein O1 (PAX3-FOXO1) fusion oncogene. Despite its discovery nearly two decades ago, the mechanisms by which PAX3-FOXO1 drives tumor development are not well characterized. Previously, we reported that PAX3-FOXO1 supports aRMS initiation by enabling bypass of cellular senescence checkpoints. We have now found that this bypass occurs in part through PAX3-FOXO1-mediated upregulation of RASSF4, a Ras-association domain family (RASSF) member. RASSF4 expression was upregulated in PAX3-FOXO1-positive aRMS cell lines and tumors. Enhanced RASSF4 expression promoted cell cycle progression, senescence evasion, and tumorigenesis through inhibition of the Hippo pathway tumor suppressor MST1. We also found that the downstream Hippo pathway target Yes-associated protein 1 (YAP), which is ordinarily restrained by Hippo signaling, was upregulated in RMS tumors. These data suggest that Hippo pathway dysfunction promotes RMS. This work provides evidence for Hippo pathway suppression in aRMS and demonstrates a progrowth role for RASSF4. Additionally, we identify a mechanism used by PAX3-FOXO1 to inhibit MST1 signaling and promote tumorigenesis in aRMS.
Differential expression of matrilysin‐1 (MMP‐7), 92 kD gelatinase (MMP‐9), and metalloelastase (MMP‐12) in oral verrucous and squamous cell cancer (2003)

Squamous cell carcinoma (SCC) of the oral cavity is a highly invasive tumour of stratified squamous epithelium that spreads through degradation of the basement membrane (BM) and extracellular matrix (ECM). There are currently no reliable tissue or serum markers to predict whether the tumour has metastasized at the time of diagnosis. Verrucous carcinoma (VC) of the oral cavity is a rare low-grade variant of oral SCC that penetrates into the subepithelial connective tissue. Many matrix metalloproteinases (MMPs), such as MMP-1, -2, -7, -9, -13, and -14, as well as integrin receptors have been implicated in cancer invasion. Integrin alphavbeta6 is induced in SCC and appears to be involved in up-regulation of MMP-9 expression by oral keratinocytes and promotion of their migration. The aim of this study was to investigate whether the pattern of MMP expression or that of alphavbeta6 integrin contributes to the differences in the biological behaviour of oral SCC and VC. The results show that the less aggressive nature of oral VC may be connected to its MMP expression profile. Typically, VCs were devoid of epithelial MMP-3, -7, -9, -12 and -13 expression, compared with SCCs. MMP-19 was expressed by epithelial keratinocytes in hyperproliferative areas of verrucous hyperplasia, VC, and SCC, but was absent in the invasive cancer cell nests of SCC. MMP-26 was expressed by hyperproliferative keratinocytes in VC as well as by invasive cancer cells in SCCs. MMP-10 was expressed widely in the epithelium of all SCC specimens. alphavbeta6 integrin expression was also detected in some cases of epithelial hyperplasia but was significantly more abundant in cancers at the invasive front. The absence of MMP-7, -9 and -12 from epithelial cells may serve as a good prognostic marker of non-invasive oral carcinoma. Blocking the activity of invasion-specific MMPs or alphavbeta6 integrin might offer novel therapeutic modalities in early-stage oral carcinoma.
Culture of Social Integration: How Extractive Colonialism Promotes Contemporary Individual Income (2021)

By exploring the history of northeastern China in 1898–1911, this paper documents that extractive colonialism spurs a culture of social integration that generates a positive effect on contemporary individual income, with robustness to potential endogeneity bias. Given that the existing literature has emphasized the long-run negative economic impacts of extractive colonialism, this paper helps explain the following institutional puzzle: Why does extractive colonialism spur development in the long run? We thereby deepen understanding of colonialism and institutions from a cultural perspective.
Multi-density Clustering Based Hierarchical Path Planning (2019)

Path planning is one of the key abilities in artificial intelligence. Many different approaches exist, focusing on finding the shortest path. Obstacle density, which is often ignored by conventional approaches, has a great influence on path quality especially in off-road environment. Because obstacles along a path compromise driving safety and frequent obstacle avoidance increases vehicle control difficulty while decreases traveling speed. In this paper, a simple and efficient approach of hierarchical path planning algorithm based on multi-density clustering is proposed, aiming at finding a clear and short path to achieve an integrated goal of obstacle avoidance and path length shortness. A simulation evaluation shows that our proposed approach can find short path bypassing regions with dense obstacles efficiently.
Stabilization of the ribonuclease S‐peptide α‐helix by trifluoroethanol (1986)

The effects of trifluoroethanol (TFE) on the stability of the alpha-helix formed by ribonuclease S-peptide, residues 1-19 of ribonuclease A, were studied by measuring circular dichroism as a function of TFE concentration, pH, and temperature. The S-peptide forms an unusually stable alpha-helix, which is known to be stabilized by TFE. The magnitude of the effect of charged groups on the peptide, manifested by the change in alpha-helix stability as a function of pH, was not altered significantly by either TFE concentration or temperature, indicating that the lower dielectric constant of TFE is not important in the stabilization of this alpha-helix. This suggests that the alpha-helix might be stabilized by many interactions in addition to the effects of charges. The titration curve of circular dichroism vs. TFE concentration appears to be cooperative at 0 degree C, but becomes progressively less cooperative at temperatures between 25 and 75 degrees C. The properties of the TFE stabilization indicate that TFE might be a useful probe with which to measure the stability of marginally stable peptides and small proteins.
mMARCO: A Multilingual Version of the MS MARCO Passage Ranking Dataset (2021)

The MS MARCO ranking dataset has been widely used for training deep learning models for IR tasks, achieving considerable effectiveness on diverse zero-shot scenarios. However, this type of resource is scarce in languages other than English. In this work, we present mMARCO, a multilingual version of the MS MARCO passage ranking dataset comprising 13 languages that was created using machine translation. We evaluated mMARCO by finetuning monolingual and multilingual reranking models, as well as a multilingual dense retrieval model on this dataset. We also evaluated models finetuned using the mMARCO dataset in a zero-shot scenario on Mr. TyDi dataset, demonstrating that multilingual models finetuned on our translated dataset achieve superior effectiveness to models finetuned on the original English version alone. Our experiments also show that a distilled multilingual reranker is competitive with non-distilled models while having 5.4 times fewer parameters. Lastly, we show a positive correlation between translation quality and retrieval effectiveness, providing evidence that improvements in translation methods might lead to improvements in multilingual information retrieval. The translated datasets and finetuned models are available at https://github.com/unicamp-dl/mMARCO.
Dynamic State Estimation for Power System Control and Protection (2020)

Dynamic state estimation (DSE) accurately tracks the dynamics of a power system and provides the evolution of the system state in real-time. This paper focuses on the control and protection applications of DSE, comprehensively presenting different facets of control and protection challenges arising in modern power systems. It is demonstrated how these challenges are effectively addressed with DSE-enabled solutions. As precursors to these solutions, reformulation of DSE considering both synchrophasor and sampled value measurements and comprehensive comparisons of DSE and observers have been presented. The usefulness and necessity of DSE based solutions in ensuring system stability, reliable protection and security, and resilience by revamping of control and protection methods are shown through examples, practical applications, and suggestions for further development.
Calmodulin localization in bone and cartilage (1984)

The localization of calmodulin (CaM), a calcium-dependent regulatory protein, was demonstrated in the following rat skeletal tissues by the indirect immunofluorescence method: a) growth plate cartilage of fetal and juvenile long bones, b) fetal epiphyseal cartilage, c) juvenile hyaline costal cartilage, d) neonatal mandibular condylar cartilage, e) neonatal diaphyseal lamellar bone. CaM was not detected in perichondrial and periosteal cells. Mature and mineralizing chondrocytes demonstrated the highest labelling intensities.
Zur Konfiguration des Vitamin‐D3‐Metaboliten 25, 26‐Dihydroxycholecalciferol: Synthese von (25S,26)‐ und (25R,26)‐Dihydroxycholecalciferol (1981)

Configuration of the Vitamin‐D 3 ‐Metabolite 25,26‐Dihydroxycholecalciferol: Synthesis of (25 S ,26)‐ and (25 R ,26)‐Dihydroxycholecalciferol For selective synthesis of the title compounds, (25 S )‐ 1b and (25 R )‐ 1b (Scheme 1) , the protected cholesterol precursors (25 S )‐ 6 and (25 R )‐ 6 were prepared from stigmasterol‐derived steroid‐units 4a‐d and C 5 ‐side chain building blocks 5a–d by Grignard ‐ or Wittig ‐coupling (Scheme 2) , the configuration at C(25) of the target compounds being already present in the C 5 ‐units. Conversion of the cholesterol intermediates to the corresponding vitamin‐D 3 derivatives was carried out via the 7,8‐didehydrocholesterol compounds (25 S )‐ 2b and (25 R )‐ 2b (Scheme 1) , using the established photochemical‐thermal transformation of the 5,7‐diene system to the seco ‐triene system of cholecalciferol. The configuration at C(25) of the cholesterol precursors as assigned on basis of the known configuration of the C 5 ‐units used, was found to be in agreement with the result of a single crystal X‐ray analysis on compound 11 . The configuration at C(25) remained untouched on conversion of the cholesterol ring system to the seco ‐triene system of vitamin D 3 as evident from comparison of the lanthanide‐induced CD. Cotton effects observed for (25 S )‐ 3b and (25 S ) 1b . 25,26‐Dihydroxycholecalciferol observed as a natural vitamin‐D 3 metabolite has (25 S )‐configuration.
Supplementary Table 2 from AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells (2023)

&lt;p&gt;PDF file, 55KB, Supplementary table 2: Rate of incidence of disease recurrence according to AIB1, HER2, tumour grade, tumour size and nodal status in breast cancer patients treated with first-line AI.&lt;/p&gt;
Endothelin-1 and Endotoxemia (1993)

Sepsis leads to changes in blood volume and distribution. In the experiments reported here we monitored circulatory changes during endotoxemia and their relation to portal and systemic levels of endothelin-1 (ET-1). Piglets were monitored cardiovascularly under ketamine anesthesia for 6 h after an endotoxin infusion (saline controls). ET-1 levels in plasma were analyzed by RIA. In both portal and systemic blood a twofold increase in ET-1 levels was found after 1 h. This level remained significantly elevated for a further 3 h. This increase was concurrent with a drop in cardiac output, systemic vascular resistance, and blood pressure. In the portal circulation there was increased portal pressure and vascular resistance. There was no significant difference between the systemic and portal levels of ET-1.
GABA Receptors in Clonal Cell Lines: A Model for Study of Benzodiazepine Action at Molecular Level (1979)

A "recptor unit" for gamma-aminobutyric acid (GABA), which includes brainlike receptor binding sites for tritium-labeled GABA and benzodiazepines (diazepam, clonazepam, and flunitrazepam) and a thermostable endogenous protein (GABA modulin) that inhibits both GABA and benzodiazepine binding, has been demonstrated in membranes prepared from NB2a neuroblastoma and C6 glioma clonal cell lines. In these cells, as in brain, diazepam (1 micromolar) prevents the effect of GABA modulin, and in turn GABA (0.oma and, to a lesser extent, the glioma cells represent a suitable model to study the interactions and the sequence of membrane and intracellular events triggered by the stimulation of benzodiazepine and GABA receptors.
Determination of the Polarities of Some Ionic Liquids Using 2-Nitrocyclohexanone as the Probe (2005)

Solute-solvent interactions on the keto-enol tautomerism of 2-nitrocyclohexanone in several organic solvents and room-temperature ionic liquids (RTILs) have been analyzed in terms of multiparameter equations. Permittivity and cohesive pressure values of the RTILs, unavailable by direct measurements, have been derived.
Inventory management of supply chain with robust control theory: literature review (2017)

Supply chain management (SCM) has become a vital tool for organisations, which desire to improve performance and resilience. More and more attention in SCM has been dedicated to inventory. The great potential of control theory to handle inventory problems was evidenced since the early 1950s. In particular, the robust control which is devoted to dealing with uncertainties and minimising the worst case value of disturbances represents a useful tool to help research in inventory management. This paper aims to provide a review of 37 articles covering the application of robust control in modelling and control of inventory problems according to the considered uncertainties mainly in demand and delay time.
Complex permittivity measurement of dielectric materials using nonradiative dielectric guide at millimeter wavelength (1996)

Abstract In this paper, as a method for measurement of complex permittivity of millimeter‐wave dielectric materials, a transmission resonator method is proposed which is made of a dielectric resonator with both sides open placed in a nonradiative dielectric (NRD) guide. For the evaluation of the surface resistance of the conductor indispensable for measurement of the complex permittivity, a pair of TE oml mode resonators are placed coaxially and are mutually coupled. The difference of the conductor losses for the even and odd mode resonances of this resonator system is detected as the difference of the unloaded Q's so that the surface resistance is derived. The special features of the present measurement method are to evaluate the conductor surface resistance at a high sensitivity in a condition close to the resonator with both ends short‐circuited and to use a resonator with both ends open‐circuited for sample measurement because the effect of the surface resistance is small so that high accuracy is obtained as a whole. By using an NRD guide excitation method, a measurement system is realized which affects very little the unloaded Q of the resonator system and the electromagnetic field distribution. For the calculations of the complex permittivity, the eigenvalue calculation by the finite element method and the perturbation method by Kajfez are combined. For the samples with its relative permittivity of 24 and the loss tangent of 2 × 10 −4 , the measurement fluctuations are less than 0.005 percent for the resonant frequency and less than 1 percent for the unloaded Q. The measurement accuracy for the relative permittivity is less than 0.4 percent and that for the loss tangent is less than 3 percent.
Divergent Synthesis of Ultrabright and Dendritic Xanthenes for Enhanced Click‐Chemistry‐Based Bioimaging (2022)

Biorthogonal labelling with fluorescent small molecules is an indispensable tool for diagnostic and biomedical applications. In dye-based 5-ethynyl-2'-deoxyuridine (EdU) cell proliferation assays, augmentation of the fluorescent signal entails an overall enhancement in the sensitivity and quality of the method. To this end, a rapid, divergent synthetic procedure that provides ready-to-click pH-insensitive rhodamine dyes exhibiting outstanding brightness was established. Compared to the shortest available synthesis of related high quantum-yielding rhodamines, two fewer synthetic steps are required. In a head-to-head imaging comparison involving copper(I)-catalyzed azide alkyne cycloaddition reactions with in vitro administered EdU, our new 3,3-difluoroazetidine rhodamine azide outperformed the popular 5-TAMRA-azide, making it among the best available choices when it comes to fluorescent imaging of DNA. In a further exploration of the fluorescence properties of these dyes, a set of bis-MPA dendrons carrying multiple fluorescein or rhodamine units was prepared by branching click chemistry. Fluorescence self-quenching of fluorescein- and rhodamine-functionalized dendrons limited the suitability of the dyes as labels in EdU-based experiments but provided new insights into these effects.
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models (2017)

Selenoprotein P (SeP) functions as a selenium (Se)-supply protein. SeP is identified as a hepatokine, promoting insulin resistance in type 2 diabetes. Thus, the suppression of Se-supply activity of SeP might improve glucose metabolism. Here, we develop an anti-human SeP monoclonal antibody AE2 as with neutralizing activity against SeP. Administration of AE2 to mice significantly improves glucose intolerance and insulin resistance that are induced by human SeP administration. Furthermore, excess SeP administration significantly decreases pancreas insulin levels and high glucose-induced insulin secretion, which are improved by AE2 administration. Epitope mapping reveals that AE2 recognizes a region of human SeP adjacent to the first histidine-rich region (FHR). A polyclonal antibody against the mouse SeP FHR improves glucose intolerance and insulin secretion in a mouse model of diabetes. This report describes a novel molecular strategy for the development of type 2 diabetes therapeutics targeting SeP.