gebhart/patrepeval huggingface dataset:
Multiplane Transesophageal Echocardiographic Imaging and Three‐Dimensional Reconstruction (1992)

This study presents our preliminary experience in multiplanar transesophageal echocardiography. In addition, an attempt was made in one patient to reconstruct the left ventricle in three dimensions using the sequential planes obtained from the multiplanar approach.
Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients (2008)

Cyclooxygenase-2 (COX-2) is associated with breast tumour progression. Clinical and molecular studies implicate human epidermal growth factor receptor 2 (HER2) in the regulation of COX-2 expression. Recent reports raise the possibility that HER2 could mediate these effects through direct transcriptional mechanisms. The relationship between HER2 and COX-2 was investigated in a cohort of breast cancer patients with or without endocrine treatment. A tissue microarray comprising tumours from 560 patients with 10-year follow-up was analysed for HER2, ERK1/2, polyoma enhancer activator 3 (PEA3) and COX-2 expression. Subcellular localisation of HER2 was assessed by immunofluorescence and confocal microscopy. Expression of markers examined was analysed in relation to classic clinicopathological parameters and disease-free survival in the presence and absence of tamoxifen. COX-2 expression associated with both membranous and nuclear expression of HER2 (P=0.0033 and P<0.00001 respectively). No association was detected between COX-2 and either ERK1/2 or PEA3 (P=0.7 and P=0.3 respectively). None of the markers were found to be independently prognostic. Membrane HER2, nuclear HER2 and COX-2, however, were all found to predict poor disease-free survival in patients on endocrine treatment (P=0.0017, P=0.0003 and P=0.0202 respectively). Moreover, patients who were positive for COX-2 predicted adverse effects of tamoxifen (P=0.0427). These clinical ex vivo data are consistent with molecular observations that HER2 can regulate COX-2 expression through direct transcriptional mechanisms. COX-2 expression correlates with disease progression on endocrine treatment. This study supports a role for COX-2 as a predictor of adverse effects of tamoxifen in breast cancer patients.
WLCD: a new system for wafer level CD metrology on photomasks (2009)

With decreasing feature size, the requirements for CD uniformity (CDU) on the wafer have become crucial for achieving the required yield in the wafer fab. This is related to tighter CDU specifications on the photomask. Currently, mask CDU is mainly measured by mask CD SEM tools. However, due to strong OPC and high MEEF mask CDU is not directly related to wafer CDU. A new Aerial Imaging based optical system has been developed by Carl Zeiss SMS which measures wafer level CD already on photomasks under scanner conditions. First results of the alpha tool show that the new tool has extremely good CD repeatability and stability. Furthermore, the effect of the scanner settings on CD uniformity is demonstrated.
Electron tomography provides a direct link between the Payne effect and the inter-particle spacing of rubber composites (2014)

Rubber-filler composites are a key component in the manufacture of tyres. The filler provides mechanical reinforcement and additional wear resistance to the rubber, but it in turn introduces non-linear mechanical behaviour to the material which most likely arises from interactions between the filler particles, mediated by the rubber matrix. While various studies have been made on the bulk mechanical properties and of the filler network structure (both imaging and by simulations), there presently does not exist any work directly linking filler particle spacing and mechanical properties. Here we show that using STEM tomography, aided by a machine learning image analysis procedure, to measure silica particle spacings provides a direct link between the inter-particle spacing and the reduction in shear modulus as a function of strain (the Payne effect), measured using dynamic mechanical analysis. Simulations of filler network formation using attractive, repulsive and non-interacting potentials were processed using the same method and compared with the experimental data, with the net result being that an attractive inter-particle potential is the most accurate way of modelling styrene-butadiene rubber-silica composite formation.
Efficient error recovery techniques in a novel multimedia streaming framework with peer-paired collaboration (2003)

Recently, active research has gone to application-level multicast that tries to bring all the merits of unicast and IP multicast together while avoiding their drawbacks. How to efficiently recover from errors in such a system is a difficult question yet to be answered. The current research focus is primarily on developing local error recovery techniques, but these techniques would not work in case of shared losses, which often occur in application-level multicast. In this paper, a novel multimedia streaming framework called peer-paired pyramid streaming (P/sup 3/S) is proposed. It is basically a hybrid client/server and peer-to-peer structure. In P/sup 3/S, clients are hierarchically organized and those at the same level are coupled and peer-pairs are then formed. Based on P/sup 3/S, we introduce some controlled delay between packets that are vulnerable to shared losses to combat with the shared losses. The proposed technique is supported by both theoretical and experimental results presented in this paper.
Investigation into the role of the serine protease HtrA in Yersinia pestis pathogenesis (2000)

The HtrA stress response protein has been shown to play a role in the virulence of a number of pathogens. For some organisms, htrA mutants are attenuated in the animal model and can be used as live vaccines. A Yersinia pestis htrA orthologue was identified, cloned and sequenced, showing 86% and 87% similarity to Escherichia coli and Salmonella typhimurium HtrAs. An isogenic Y. pestis htrA mutant was constructed using a reverse genetics approach. In contrast to the wild-type strain, the mutant failed to grow at an elevated temperature of 39 degrees C, but showed only a small increase in sensitivity to oxidative stress and was only partially attenuated in the animal model. However, the mutant exhibited a different protein expression profile to that of the wild-type strain when grown at 28 degrees C to simulate growth in the flea.
Design and implementation of employee education and training system based on SSH framework (2013)

The tobacco industry is of vital importance for the nation's economy and people's life safety, so it is necessary to educate the employees in tobacco industry. This paper designs a remote education and training system suitable for employees in tobacco industry based on presently popular SSH(struts+ spring+ hibernate) framework including functions of courseware browsing, video on demand, online test, and so on. The system has a good user interface and is easy to operate. Finally, corresponding experiments for existing network bottleneck problems have been done and then the future work is proposed.
A Prospective, Randomized Study of Three Operations for Acute Rupture of the Anterior Cruciate Ligament. Five-Year Follow-up of One Hundred and Thirty-one Patients* (1996)

A five-year, prospective, randomized follow-up study was done to compare three methods for repair of a rupture of the anterior cruciate ligament of the knee; acute primary repair (Group 1), acute repair with a synthetic ligament-augmentation device (Group 2), and acute repair augmented with an autologous bone-patellar ligament-bone graft (Group 3). One hundred and fifty patients who had an acute rupture of the anterior cruciate ligament were randomized to one of the three repair groups, with fifty patients in each group. The patients were between sixteen and fifty years old (mean, twenty-nine years old). All patients had the operation within ten days after the injury. The rehabilitation protocol was identical for each group. The patients were evaluated prospectively at one, two, and five years with use of the Tegner scoring system for level of activity and the scoring system of Lysholm and Gillquist for function, and the stability of the knee was assessed with clinical examination and with use of the KT-1000 arthrometer. One hundred and thirty-one patients completed the study and ten other patients were known to have had a failure of the procedure, a 94 percent rate of follow-up. All three groups had a lower level of activity at the five-year follow-up evaluation than they had had before the injury. The patients who had had augmentation with a patellar-ligament graft had a significantly higher mean level of activity at two years than those who had had non-augmented repair with (p = 0.002) and those who had had repair with a synthetic ligament-augmentation device (p = 0.01). They also had a significantly higher mean level of function at two years than those who had had non-augmented repair (p = 0.0001) and those who had had repair with a synthetic ligament-augmentation device (p = 0.03) and a significant higher mean level of function at five years than those who had had non-augmented repair (p = 0.004). The ability to attain full extension improved significantly in all three groups during the five-year follow-up period; the highest gains occurred in the group that had had augmentation with a patellar-ligament graft. Rotatory and anterior instability progressively increased during the follow-up period for all three groups. At one, two, and five years, the knees that had had repair with a patellar-ligament graft were significantly more stable than those that had had non-augmented repair and those that had had repair with a ligament-augmentation device (p < 0.0001 to p = 0.03). The findings of this study reinforce the conclusions of our two-year follow-up report that a non-augmented primary repair should not be performed, a repair with a ligament-augmentation device has an unacceptably high rate of failure (more than one-third of the patients), and a repair that is augmented with the patellar ligament has the best outcome.
Alpha-Fetoprotein Serum Levels and the Development of Estrogen-Sensitive Cell Multiplication in the Hamster Uterus (1983)

Subcutaneous injections of 5 or 25 micrograms estradiol-17 beta (E2)/kg in ovariectomized adult hamsters produced substantial increases in uterine wet weight, protein content and the mitotic indices of the glandular and luminal epithelia. However, no significant increase was seen in total uterine DNA. Intact hamsters from 2 to 25 days of age received a daily subcutaneous injection of 5 micrograms E2/kg for 2 consecutive days. Significant increases in uterine wet weight and protein content first occurred at 8 and 17 days, respectively. No significant increase was observed in uterine DNA. In a separate experiment, hamsters between 2 and 20 days of age received one subcutaneous injection of 5 micrograms E2/kg. Mitotic indices in the stroma were increased at 6 and 10 days of age. Mitotic indices in the luminal epithelium were significantly increased only at 6 days of age. Rocket immunoelectrophoresis revealed a sharp decline in serum alpha-fetoprotein (AFP) concentrations after 2 days of age. Estradiol concentrations in the sera of immature hamsters gradually decreased from 55 pg/ml at 0 days of age to 17 pg/ml at 20 days of age. These results provide a quantitative analysis of the effects of E2 upon cell proliferation in the hamster uterus. The correlation of declining AFP levels and the incipience of the mitotic response to estrogen suggests that AFP may directly inhibit estrogen-sensitive cell multiplication in the neonate. Other possible causes for the lack of a mitotic response in the uterus of the newborn hamster to the administration of E2 are also discussed.
Regulators of GPCR Activity (2005)

A single photon of light, triggering the physicochemical isomerization of an 11-cis-retinal to its all-trans form, initiates the process of vision. The retinal moiety serves as a tethered ligand for the photoreceptor rhodopsin, a G protein-coupled receptor (GPCR); within milliseconds, the conformational change in rhodopsin that occurs as a result of the retinal isomerization catalyzes guanosine 5′-triphosphate (GTP) for guanosine 5′-diphosphate (GDP) exchange on the heterotrimeric G protein transducin, transducin-dependent activation of a cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE), and the closure of cGMP-gated ion channels. The resulting hyperpolarization of the rod outer segment membrane inhibits release of the neurotransmitter glutamate from the photoreceptor terminal, and the light-induced stimulus is transmitted through the neural network of the retina to the central nervous system (CNS) for processing.
A STRAIGHT INSTEAD OF COILED TENCKHOFF CATHETER (TC) MAY BE THE FIRST CHOICE (2003)

The shape of the peritoneal dialysis (PD) catheter might influence the outcome of technical problems at start of PD. This randomized study using either coiled versus straight double cuffed TC was performed to find if technical problems would differ. Included: 24 pts (19 men 5 women, median age 57 years, range 19–85). The first TC: in 14 a coiled (one selected by bias) and 10 a straight TC. If a second was needed: 3 a coiled and 4 a straight. Insertion was by open surgery with the aid of a stylet aiming to locate the catheter in the lower left abdominal cavity using the insertion technique described by Stegmayr et al (1999). The study period was until functioning continuous ambulatory PD. 7 of 14 coiled catheters had a poor outflow due to malposition and 6 of them had to be changed (2 into coiled and 4 into straight TC). Initial drainage was impaired in 2 of the straight TCs due to fibrin or blood clots (one changed into a coiled TC, the other normalized after clot aspiration). After the 2nd insertion 2 of 3 coiled functioned and 4 of 4 straight TCs). Significant fewer malposition-failures were achieved with the straight versus coiled TCs (in the first series p=0.019 as well as after including data from the second insertion p=0.021). Data indicate that the risk for malposition failures using a straight TC is not a great problem and this type of TC for us is the first choice. Coiled TC tends to be buried into the omentum more frequently than straight.
Towards Change Propagating Test Models in Autonomic and Adaptive Systems (2011)

Autonomic and adaptive computing systems can add, remove, and replace their own components in response to a changing environment. Self-adaptation facilitates the performance of automated maintenance and configuration tasks, but makes it possible for faults to be introduced into the software at runtime. To address this issue, researchers have developed approaches for integrating runtime testing into autonomic and adaptive software systems. An important aspect of runtime testing approaches for autonomic software is the provision of a framework for regression testing, which determines whether modifications have introduced faults into previously tested components. However, after adaptation occurs in autonomic software, a predefined test set may no longer be applicable due to changes in the program structure. Investigating techniques for dynamically updating regression tests after adaptation is therefore necessary to ensure such approaches can be applied in practice. In this paper we describe a model-driven approach that maps structural adaptations in autonomic software, to updates for its runtime test model. We provide a workflow and meta-model to support the approach, referred to as Test Information Propagation (TIP). To demonstrate TIP, we have developed a prototype that simulates a reductive change to an autonomic, service-oriented healthcare application. Conducting the simulation has provided us with much insight into this highly challenging research problem.
COMPARISON OF CLINICAL OUTCOMES OF LIVING DONOR KIDNEY TRANSPLANTATION IN FEMALE RECIPIENTS WITH BIRTH HISTORY ACCORDING TO THE RELATION TO A DONOR (2020)

Live-donor kidney transplantation has significantly increased the size of the donor pool, and live-unrelated kidney transplantation, especially spousal donation has increased exponentially. Living unrelated and related kidney transplantation has been shown to have similar allograft survival. However, the effect of donor-recipient relationship in living-related and unrelated kidney transplantation on graft and patient survival remains uncertain. Thus, the aim of this study was to evaluate the effect of live-donor types and graft outcomes. From January 2009 to January 2018, a total of 2,680 kidney transplants were performed at Asan Medical Center, while 2,060 living donor kidney transplantations were performed. We studied 864 female recipients from living donors with pregnancy history, and HLA-incompatible, retransplantation and those without or unknown pregnancy history were excluded. The female recipients were categorized into three groups; Offspring-to-mother (Group I), husband-to-wife (Group II), and other unrelated donors (Group III). The primary endpoint of this study was biopsy-proven acute rejection and graft survival. We also evaluated delayed graft function (DGF), death-censored graft failure and mortality. Number of HLA ABDR mismatch was significantly lower in group I and there were more ABO incompatible kidney transplantation in group II compared to the other groups. There were 4 (2.3%), 3 (1.9%), and 3 (5.4%) cases of mortality in group I, group II, and group III, respectively (p= 0.352). There was no significant difference in the one, three, and five years patient survival among groups (p=0.444). There was no significant difference in the biopsy-proven acute rejection between the three groups. Clinical rejection and DGF occurred at a high rate in group II compared to group I and group III, but there was no statistically significant difference between the three groups. We conclude that both offspring and spousal living donor transplants have similar patient and graft survival and can be considered whenever feasible for female recipients with multiple donor options.
Fast odd discrete cosine transform algorithms (1990)

It is shown that an N point type I odd discrete cosine transform can be reformulated as a (2N − 1) point DFT of a real-symmetric sequence efficiently computed by the real-symmetric PFA-FFT. Using simple index mappings, the type II and III ODCTs are efficiently computed from the ODCT-I of the same length. The ODCT-IV are then computed from ODCT-II or III using simple recurrence formulas.
The CCVV high-current megavolt-range DC accelerator (2003)

The authors describe a constant-current variable-voltage (CCVV) accelerator, intended to operate in the megaelectronvolt energy range but tunable down to a few percent of magnetoelectronvolt without loss of beam current. They present experimental results from a 200-keV single-beam prototype system designed to accelerate up to 0.2 A of H/sup +/ or H/sup -/ or the equivalent current of heavier ions. The beam is accelerated by a series of stackable 100-keV modules, the number depending on the maximum beam energy required. The authors discuss a proposed 1-MeV accelerator and a conceptual design for a multiaperture system accelerating 10 A or D/sup -/ ions to 1-2 MeV for current drive in a fusion reactor. The use of electrostatic quadrupole focusing allows a conservative design with reduced risk of voltage breakdown and makes it possible to maintain high currents while varying the beam energy. These features are useful for fusion reactor startup and for industrial applications, such as semiconductor processing and surface hardening.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Data from A Phase I Study of Veliparib (ABT-888) in Combination with Low-Dose Fractionated Whole Abdominal Radiation Therapy in Patients with Advanced Solid Malignancies and Peritoneal Carcinomatosis (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The combination of low-dose radiotherapy with PARP inhibition has been shown to enhance antitumor efficacy through potentiating DNA damage. We combined low-dose fractionated whole abdominal radiation (LDFWAR) with escalating doses of veliparib (ABT-888), a small-molecule PARP inhibitor, in patients with peritoneal carcinomatosis from advanced solid tumor malignancies.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Patients were treated with veliparib (80–320 mg daily) for a total of 3 cycles. LDFWAR consisted of 21.6 Gy in 36 fractions, 0.6 Gy twice daily on days 1 and 5 for weeks 1–3 of each cycle. Circulating tumor cells (CTC) were collected and evaluated for γ-H2AX. Quality of life (QoL) was assessed using the EORTC-QLQ-C30 questionnaire.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Twenty-two patients were treated. Treatment-related grade 3 and 4 toxicities included lymphopenia (68%), anemia (9%), thrombocytopenia (14%), neutropenia (4%), leukopenia (9%), ascites (4%), vomiting (4%), and dyspnea (4%). No objective responses were observed. Disease stabilization (≥24 weeks) was observed in 7 patients (33%). Median progression-free survival (mPFS) was 4.47 months and median overall survival (mOS) was 13.04 months. In the subset of 8 ovarian and fallopian cancers, mPFS was 6.77 months and mOS was 17.54 months compared with mPFS 2.71 months and mOS 13.01 months in others. Patients with ovarian and fallopian cancers had better QoL over time than those with other cancers. An increased percentage of γ-H2AX–positive CTCs was observed in a subset of patients (3/6 with &gt;2 CTCs at baseline).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Combined veliparib and LDFWAR is a well-tolerated regimen that resulted in prolonged disease stability for some patients with advanced solid tumors and carcinomatosis, particularly in the ovarian and fallopian cancer subpopulation. &lt;i&gt;Clin Cancer Res; 21(1); 68–76. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Melatonin: shedding light on infertility? - a review of the recent literature (2014)

In recent years, the negative impact of oxidative stress on fertility has become widely recognised. Several studies have demonstrated its negative effect on the number and quality of retrieved oocytes and embryos following in-vitro fertilisation (IVF). Melatonin, a pineal hormone that regulates circadian rhythms, has also been shown to exhibit unique oxygen scavenging abilities. Some studies have suggested a role for melatonin in gamete biology. Clinical studies also suggest that melatonin supplementation in IVF may lead to better pregnancy rates. Here we present a critical review and summary of the current literature and provide suggestions for future well designed clinical trials.
Techniques for the simulation of large-scale integrated circuits (1979)

New techniques for the efficient simulation of large-scale integrated MOS circults are described. These techniques have been implemented in the computer program SPLICE which combines circuit, timing, and logic analyzes in a single package. The use of SOR-Newton methods permits all three forms of analysis to be performed simultaneously, while event-control is used to enhance execution speed. The performance of SPLICE for the simulation of large NMOs circuits is also described.