gebhart/patrepeval huggingface dataset:
High on-treatment platelet reactivity by more than one agonist predicts 12-month follow-up cardiovascular death and non-fatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting (2010)

There is some data available on the role of high on-treatment platelet reactivity by ADP whereas, as regards arachidonic acid or other agonists, there is no proof of the best cut-off for identifying populations with a different cardiovascular outcome by the construction of appropriate receiver-operator characteristics (ROC) curves. We enrolled 1,108 acute coronary syndrome patients undergoing percutaneous coronary intervention (PCI) with stent implantation and followed them up for 12 months. Platelet reactivity was assessed by light transmission aggregometry (LTA) using 10 microM ADP, 1 mM arachidonic acid (AA) and 2 microg/ml collagen. At a 12-month follow-up, we found 37 cardiovascular deaths (3.3%), 54 non-fatal myocardial infarctions (MI) (4.8%) and 154 target vessel revascularisations (TVR) (13.8%). ROC analysis demonstrated that 10 microM ADP LTA, 1 mM AA and 2 microg/ml collagen LTA were able to distinguish between patients with and without subsequent cardiovascular death and non-fatal MI (area under the curve for 10 microM ADP 0.63 (0.55-0.71), p<0.001; for 1 mM AA 0.68 (0.61-0.76), p<0.0001; for 2 microg/ml collagen 0.62 (0.52-0.73), p<0.0111), whereas no association was demonstrated with the occurrence of TVR. Ten microM ADP LTA>or=55%, 1 mM AA LTA>or=15% and 2 microg/ml collagen LTA>or=31% were identified as the optimal cut-off to predict cardiovascular death and non-fatal MI at 12-month follow-up. The contemporary platelet hyperreactivity to more than one agonist was associated with a higher risk of 12-month cardiovascular death and MI, whereas isolated platelet hyperreactivity to only one agonist had not a predictive value [10 microM ADP LTA>or=55% + 1 mM AA LTA>or=15%: odds ratio [OR]=3.6(2.4-6.1), p<0.0001; ADP LTA>or=55% + 1 mM AA LTA>or=15% + 2 microg/ml collagen LTA>or=31%: OR=4.7(2.9-7.7), p<0.0001]. In this prospective study on a large number of acute coronary syndrome patients undergoing stent implantation, we have found that high on-treatment platelet reactivity measured by LTA induced by more than one agonist--AA, ADP, collagen--is an independent risk factor for 12-month cardiovascular death and non-fatal MI. Isolated platelet hyperreactivity to only one agonist has not a predictive value for clinical recurrences.
Cardiac Electrophysiological and Hemodynamic Effects of jS-Adrenoceptor Blockade and Thoracic Epidural Analgesia in the Dog (1984)

To investigate whether thoracic epidural analgesia (TEA) has additional cardiac electrophysiological and hemodynamic effects when induced after beta-adrenergic blockade, bupivacaine (0.7-1.2 mg/kg) was injected into the epidural space at T2-3 after intravenous injection of atenolol (1.0 mg/kg) in anesthetized dogs. Cardiac electrophysiology was studied by His bundle electrography, programmed electrical stimulation, and monophasic action potential recordings. Atenolol reduced heart rate, prolonged atrio-ventricular (AV) nodal impulse conduction time and refractoriness, prolonged ventricular refractoriness and action potential duration, and decreased left ventricular (LV) dP/dt max. Addition of TEA further reduced heart rate, prolonged AV nodal conduction time and refractoriness, decreased LV dP/dt max and arterial blood pressure, but had no effect on atrial and ventricular electrophysiology. Induction of TEA during beta-blockade may thus have additive depressive effects on sinoatrial and AV nodal functions, as well as on left ventricular inotropy. The study indicates that the cardiac electrophysiological effects induced by TEA are mainly caused by decreased beta-receptor stimulation, but increased vagal activity may also contribute.
Vinflunine in platinum‐pretreated patients with locally advanced or metastatic urothelial carcinoma (2009)

Vinflunine demonstrates moderate activity in patients with platinum-pretreated UC. Toxicity is manageable and noncumulative.
Production of paroxysmal nocturnal hemoglobinuria‐like red blood cells by tea (1977)

Normal human red cells incubated with saline extracts of tea develop paroxysmal nocturnal hemoglobinuria-like defects as demonstrated by positive acid and sucrose hemolysis tests. All of a variety of tea preparations tested provoked a sensitivity to complement-dependent hemolysis and, with one exception, a moderate decrease in red cell acetylcholinesterase activity. Complement-dependent hemolysis in teaincubated red cells was inhibited by antisera to C3 and C3 activator, but not by antisera to C4. This suggests that incubation with tea may alter the red cell membrane in a way that specifically potentiates the lytic effects of the alternate pathway of complement, but not the classic pathway. Leupeptin, a protease inhibitor, also prevented complement-dependent hemolysis of red cells incubated with tea. Although the clinical consequences of these observations are unknown, the study was initiated following a report of a young male who had developed an acute limited intravascular hemolytic episode following ingestion of large quantities of a herbal tea.
Defect Detection of Shallow Pipes by UWB Sensor (2020)

Buried pipelines and cables are being broken as a result of numerous reasons. As pipes and cables are buried in the ground most of the time and could not be accessible visually, locating the destructed area is a major challenge. To this aim, Ground Penetrating Radar (GPR) could be helpful to locate the approximate location of the discrepancy in pipes and save a huge amount of time and budget. However, because the surrounding medium obstructs access to the pipes and causes clutter it could prevent the system to perform properly. Therefore, clutter reduction techniques are very instrumental to resolve this problem. This article presents Singular Value Decomposition (SVD), Principle Component Analysis (PCA), Independent Component Analysis (ICA) and Non-Negative Matrix Factorization (NMF) as clutter reduction algorithms. These algorithms are applied to a synthetic aperture radar (SAR) measurement system. Phase Shift Migration (PSM) is applied for image reconstruction. A scenario of a GPR scan was conducted to locate a discontinuity in buried pipes and the resulting images of diverse algorithms are compared by their Signal to Clutter and Noise Ratio (SCNR) and Peak Signal to Noise Ratio (PSNR). All of the algorithms are capable of detecting the crack but based on the comparisons, Non-Negative Matrix Factorization (NMF) and Independent Component Analysis (ICA) would be better options for GPR imaging.
Intraoperative Assessment of Bowel Viability (1993)

Viability of ischemic bowel was assessed in 30 dogs after mesenteric arterial ligation in a 40-cm length of ileum. Viability was evaluated using two gross features, color and peristalsis, and four objective methods including bowel wall surface oximetry (pO2), Doppler ultrasound, quantitative fluorescein fluorimetry, and myoelectric activity measured by a strain gauge probe. Each parameter was measured at 2-cm intervals within the 40-cm ischemic segment before resection and anastomosis was performed. There were seven fatal anastomotic leaks, all due to further bowel necrosis. Survival did not correlate with bowel color, presence of peristalsis, bowel wall pO2 Doppler ultrasound, or the myoelectric parameters. However, fluorescein fluorimetry was predictive of long-term viability. These results suggest that quantitative fluorescein fluorimetry may be a useful adjunct in intraoperative bowel viability assessment.
Microwave-Assisted Solid-Phase Organic Synthesis (MASPOS) as a Key Step for an Indole Library Construction (2003)

[reaction: see text] Microwave-assisted solid-phase organic synthesis (MASPOS) has been demonstrated to significantly facilitate the Cu(II)- or Pd(II)-mediated ring closure of the resin-bound 2-alkynylanilides. Under microwave irradiation at 200 degrees C [for Cu(OAc)(2), NMP] or 160 degrees C [for Pd(MeCN)(2)Cl(2), THF] for 10 min, 1-acyl-2-alkyl-5-arenesulfamoylindoles were obtained, after cleavage from the resin, in 95-99% purities and in 65-82% overall yields via a 5-step synthetic sequence.
A stopping criterion for nonbinary LDPC codes over GF(q) (2008)

Nonbinary low-density parity-check (LDPC) codes over finite fields GF(q) have a better performance than those of the binary low-density parity-check codes, at short and medium block lengths, but the decoder of GF(q)-LDPC has more complexity. In this paper, a new stopping criterion is proposed. Based on the changes of the variance of variable node¿s extrinsic information, the criterion can predict a decoding failure and decide whether the iteration of the decoder should be stopped. The simulation results show that the stopping criterion can greatly reduces the average number of required iterations of GF(q)-LDPC decoder with negligible performance loss.
Coulomb Drag as a Probe of the Nature of Compressible States in a Magnetic Field (2004)

Magnetodrag reveals the nature of compressible states and the underlying interplay of disorder and interactions. At nu=3/2 clear T(4/3) dependence is observed, which signifies the metallic nature of the N=0 Landau level. In contrast, drag in higher Landau levels reveals an additional contribution, which anomalously grows with decreasing T before turning to zero following a thermal activation law. The anomalous drag is discussed in terms of electron-hole asymmetry arising from disorder and localization, and the crossover to normal drag at high fields as due to screening of disorder.
Advanced geometric calibration and control for medical X-ray systems (2016)

Chapter 3 Chapter 4Nonparametric system identification approaches enable fast and accurate modeling of the system dynamics.Additionally, a novel approach is proposed for the identification of linear parameter varying systems. Contribution III:Fully data/model-driven geometric system calibrations, enabling the relaxation of the reproducibility condition. Contribution IV:Enable the use of actual X-ray images in the geometric calibration process.Extends the geometric calibrations from Contribution III with additional measurements.
A Thermal and Manufacturable Approach to Stabilized Diblock Copolymer Templates (2005)

Stabilization of the morphology in thin diblock copolymer films is critical for the generation of robust templates for subsequent device fabrication. Copolymers containing thermally cross-linkable groups, such as benzocyclobutene (BCB), can be annealed to induce an ordered microdomain morphology and then subsequently heated to cross-link the system, locking in the morphology and eliminating the need for multistep processing. Poly[(styrene-r-BCB)-b-lactic acid] (PSBCB-b-PLA) was synthesized by a combination of living free radical and ring-opening polymerizations. Thin films (∼30 nm) of PSBCB-b-PLA annealed at 170 °C, followed by cross-linking at 200 °C, showed that the ordered and oriented microdomain morphology was preserved. For PSBCB-b-PLA, with PLA volume fractions of 0.24 and 0.36, arrays of cylindrical microdomains of PLA oriented normal to the surface were produced in a cross-linked PS matrix. Washing these films with a weak base degraded and removed the PLA, producing a nanoporous cross-linked template.
Acral Peeling Skin Syndrome Resembling Epidermolysis Bullosa Simplex in a 10-Month-Old Boy (2013)

The acral peeling skin syndrome (APSS) is a rare autosomal recessive disorder clinically characterized by asymptomatic desquamation of the skin limited to the hands and feet and histologically by cleavage at the stratum granulosum and stratum corneum level [Kiritsi et al.: J Invest Dermatol 2010;130:1741-1746]. We report on a 10-month-old boy with a history of skin peeling limited to the hands and feet since 2 months of age. Clinical examination revealed erythematous erosions with peripheral desquamation and flaccid blisters. DNA mutation analysis detected two heterozygous TGM5 mutations: c.2T>C, p.M1T in exon 1 and c.337G>T, p.G113C in exon 3 in keeping with the diagnosis of APSS. The clinical presentation of APSS alone might be confusing and strongly resemble epidermolysis bullosa simplex making the differential diagnosis difficult.
Estudio de factibilidad para el montaje de una planta para la elaboración de laminados a partir de guadua (guadua Angustifolia Kunth), en el municipio de san Juan de Pasto, Departamento de Nariño, Colombia (2007)

El uso de la guadua en sus diferentes estados presenta un reconocimiento general, que desarrolla un ambiente propicio para la busqueda de innovadoras formas de su utilizacion de la guadua. Los guaduales como bosque productor son una nueva propuesta agroforestal y agroindustrial, un recurso renovable para la produccion de laminados. El sector de la construccion necesita una amplia variedad de productos derivados de la madera, razon por la cual el proyecto propone algunos disenos como paneles laminados, y vigas, como parte integral de solucion, con miras a ser utilizados como piezas importantes dentro de este sector, fundamentada en las ventajas estructurales, ambientales y economicas, que presenta la guadua “guadua angustifolia” frente a otros materiales.
Antioxidative and Anti-inflammatory Activities of Rosebud Extracts of Newly-Crossbred Roses (2023)

Oxidative stress and inflammation are basic pathogenic factors involved in tissue injury, pain, as well as acute and chronic diseases. Since long-term uses of steroids and non-steroidal anti-inflammatory drugs (NSAIDs) cause severe adverse effects, novel effective materials with minimal side effects are required. In this study, polyphenol content and antioxidative activity of rosebud extracts from 24 newly-crossbred Korean roses were analyzed. Among them, Pretty Velvet rosebud extract (PVRE) were found to contain high polyphenols and to show in vitro antioxidative and anti-inflammatory activities. In RAW 264.7 cells stimulated with lipopolysaccharide (LPS), PVRE down-regulated mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and thereby decreased nitric oxide (NO) and prostaglandin E2 (PGE2) production. In an air-pouch inflammation model, treatment with PVRE decreased λ-carrageenan-induced tissue exudation, infiltration of inflammatory cells including neutrophils, monocytes and lymphocytes, and tumor necrosis factor-α and interleukin-1β concentrations, as achieved with dexamethasone (a steroid). Notably, PVRE also inhibited PGE2, similar to dexamethasone and indomethacin (an NSAID). The anti-inflammatory effects of PVRE were confirmed by microscopic findings, attenuating tissue erythema, edema, and inflammatory cell infiltration. These results indicate that PVRE exhibits dual (steroid- and NSAID-like) anti-inflammatory activities by blocking both the iNOS ― NO and COX-2 ― PG pathways, and that PVRE could be a promising anti-inflammatory material for diverse issue injuries.
SEPARATION OF GROWTH INHIBITING POTENCY FROM OESTROGENICITY IN DIFFERENT WEAK OESTROGENIC DRUGS OF VARIOUS CHEMICAL STRUCTURES (1971)

ABSTRACT It was investigated in the mouse whether in some synthetic weak oestrogens the ability to inhibit sulphate incorporation rate in costal cartilage (and to retard body growth) is strictly bound to oestrogenicity. A new double isotope method was used which permits a correction of the sulphate uptake values in vivo for drug-induced alterations of the size of the exchangeable inorganic sulphate pool of the animals. All drugs were given for 6 days. Oestrogenicity was tested by the uterotrophic assay. Fenocyclin®, TACE® and methallenestril (Vallestril®) all caused a marked and dose-dependent decrease of both the rate of sulphate incorporation and of the size of the sulphate pool. The drugs also caused retardation of the weight-gain of the animals but to varying degrees. The demethylated form of methallenestril was in all respects much more active than the parent compound. The (+)-antipode of the former was less oestrogenic, but a stronger sulphate uptake inhibitor than the (−)-antipode. Sexovid® (cyclofenil; F 6066) and the related substance F 6088 caused a pronounced inhibition of sulphate incorporation without markedly affecting the size of the sulphate pool. The former was stronger weight-gain inhibitor than the latter. For most drugs there was a clear-cut correlation between the sulphation inhibiting potency and the growth retarding potency but some of them (especially Fenocyclin®) were rather weak as weight-gain inhibitors. The potency ratios between sulphate uptake-inhibiting and uterotrophic effects of all studied drugs were much higher than that of oestradiol benzoate. The potency ratio was especially outstanding with Fenocyclin®, Sexovid®, F 6088 and with the (+)-antipode of demethylated methallenestril. It is concluded that the growth retarding and sulphate incorporation-inhibiting properties of weak oestrogens are not strictly bound to classical oestrogenicity.
AES design space exploration new line for scan attack resiliency (2014)

Crypto-chips are vulnerable to side-channel attacks. Scan attack is one such side-channel attack which uses the scan-based DFT test infrastructure to leak the secret information of the crypto-chip. In the presence of scan, an attacker can run the chip in normal mode, and then by switching to the test mode, retrieve the intermediate results of the crypto-chip. Using only a few input-output pairs one can retrieve the entire secret key. Almost all the scan attacks on AES crypto-chip use the same iterative 128-bit AES design where the round register is placed exactly after the round operation. However, the attack potency may vary depending on the design of AES. In this work, we consider various designs of AES. We shed light on the impact of design style on the scan attack. We also consider response compaction in our analysis. We show that certain design decisions deliver inherent resistance to scan attack.
Back reflection of ultrasonic waves from a liquid–solid interface (1983)

A new acoustic phenomenon has recently been observed in experiments where a bounded beam of ultrasound is incident upon a smooth liquid–solid interface. A significant amount of coherent radiation is found to be backscattered in the general direction of incidence. The angle of back reflection is observed to be equal to the critical Rayleigh angle or leaky wave angle. Most of these observations were made during experiments on the Schoch displacement effect, and therefore it has been tacitly assumed that the back reflection is strongly dependent upon the angle of incidence, as is the case for the beam shifting in the Schoch effect. We present a theoretical basis for this new phenomenon. A two-dimensional incident beam of Gaussian profile is considered. By a careful analysis we isolate that part of the field on the interface which has Fourier components corresponding to backward propagating waves in the liquid. This subset of the total wave field is then considered separately and it is shown to display a maximum in a certain direction, close to the critical Rayleigh angle. This peak in the angular pattern of the scattered field corresponds to an evanescent reflection boundary. We discuss the dependence of the effect upon certain parameters. The amplitude is shown to decrease as the beam width is increased, and it increases with increasing Schoch displacement. This backscattering is present for all angles of incidence; there is nothing inherently special about the Rayleigh angle.
3D lung registration using splineMIRIT and Robust Tree Registration (RTR) (2010)

status: Published
Iterative Frequency-Domain Receivers for the Uplink of Cellular Systems with Base Station Cooperation (2012)

In this paper we consider the uplink transmission in BS (Base Station) cooperation schemes where users in adjacent cells share the same physical channel and the signals received by each BS are sent to a CPU (Central Processing Unit) that combines the different received signals associated to a given user and/or performs the user separation. We consider SC-FDE signals (Single-Carrier with Frequency-Domain Equalization) combined with iterative frequency-domain receivers based on the IB-DFE concept (Iterative Block Decision Feedback Equalization). Our performance results show that the proposed receivers allow significant macro-diversity gains as well as an efficient user separation, with performance close to the MFB (Matched Filter Bound), making these techniques an excellent choice for the uplink transmission in future broadband wireless systems employing BS cooperation schemes.
A 0.380-THz frequency quadrupler based on Constructive Wave Oscillator in 130-nm SiGe BiCMOS (2017)

The first Constructive Wave Oscillator (CWO) based frequency quadrupler has been demonstrated in 130-nm SiGe BiCMOS. Proposed architecture efficiently generates a 0.380 THz signal using a strong fundamental CWO operating at W-band. Eight-section CWO produces 95 GHz signals that are distributed along the ring with 45 degree phases. Frequency quadrupler combines the signals from the CWO, fo, and produces a signal at 4fo. The frequency quadrupler circuit dissipates 76 mW of DC power from 2V supply. The CWO based frequency quadrupler operating at 380 GHz has a -28 dBm output power into 50 ohms load with a phase noise of -85 dBc per Hz at 1 MHz offset.
Adaptive optical post distortion linearization (2005)

A technique to suppress optical nonlinearities is demonstrated using adaptive optical domain post distortion. The concept, rooted in electrical domain linearization, mitigates optical nonlinearities by generating sidebands that are equal but opposite in phase from the unwanted components. We model and experimentally demonstrate >20 dB extinction in four wave mixing by an adaptive phase controller and computer feedback loop.
Strategic interventions for hyperactive children (1981)

International experts from the newly-independent states of the former Soviet Union analyse the nuclear issues complicating the relations between Russia and its new neighbours. This text emphasises global issues of ecological safety and international military security.
Possible transmission flow of SARS-CoV-2 based on ACE2 features (2020)

Abstract Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.