gebhart/patrepeval huggingface dataset:
Rab31 upregulates MUC1-C expression. (2015)

&lt;p&gt;A. MCF-7 (left) and ZR-75-1 (right) cells were stably transfected to express a control siRNA (CsiRNA) or a Rab31 siRNA. Lysates from the transfectants were immunoblotted with the indicated antibodies. B. MCF-7/Rab31siRNA (left) and ZR-75-1/Rab31siRNA (right) cells were treated with the indicated concentrations of chloroquine (CQ) for 24 h. Lysates from the treated cells were immunoblotted with the indicated antibodies. C. RNA from MCF-7, ZR-75-1 and MCF-10A cells was analyzed for Rab31 mRNA levels by qRT-PCR. The results (mean&lt;u&gt;+&lt;/u&gt;SD of three determinations) are expressed as relative Rab31 mRNA levels compared to that obtained for MCF-7 cells. D. Lysates from MCF-7, ZR-75-1 and MCF-10A cells were immunoblotted with the indicated antibodies. E. MCF-10A cells were stably transfected to express an empty vector, Rab31 or Rab31(S20N). Lysates from the transfected cells were immunoblotted with the indicated antibodies.&lt;/p&gt;
Expression of EGF, EGF‐receptor, p53, v‐erb B and ras p21 in colorectal neoplasms by immunostaining paraffin‐embedded tissues (1994)

Immunohistochemical studies were performed to clarify the significance of the expression or overexpression of epidermal growth factor (EGF), EGF-receptor (EGFR), p53, v-erb B, ras p21 in 23 cases each of tubular adenoma and adenocarcinoma. The expression of EGF, EGFR, p53, v-erb B, and ras p21 in paraffin-embedded tissues, from 46 patients with colorectal tumors (adenoma: 23 cases; 14 mild dysplasia, six moderate dysplasia, three severe dysplasia, adenocarcinoma: 23 cases; 17 well differentiated, two moderately differentiated, three poorly differentiated, one mucinous carcinoma was analyzed immunohistochemically using anti-EGF, EGFR, p53, v-erb B and ras p21 antibodies. The EGF and ras p21 tended to express more strongly in carcinoma cases than in the adenoma cases, and in severe and moderate dysplasia than in mild dysplasia (EGF: stained positive in five adenomas [21.74%] and 17 adenocarcinomas [73.91%]; ras p21: stained positive in six adenomas [26.09%] and 14 adenocarcinomas [60.87%]. The EGFR stained positive in two adenomas (8.70%) and two adenocarcinomas (8.70%). The p53 and v-erb B showed positive staining only in the carcinoma cases (p53: stained positive in four cases [17.39%]; v-erb B: stained positive in eight cases [34.78%]). This study suggests that these factors seem to have some role in the progression of colon neoplasms. It suggests that genetic alteration is not always equal to the overexpression of protein products, but that it reflects them well, and that the staining makes some contribution to differential diagnosis in colorectal neoplasms.
On Semi-Symmetric Metric Connection (2004)

We study the property of D-conharmonic transformation and obtain that the D-conharmonic transformation is actually the identity transformation.
Comparison of immune preservation between CO2 pneumoperitoneum and gasless abdominal lift laparoscopy. (2002)

Our results showed that the beneficial immune response obtained in the CO2 gas insufflation laparoscopic procedure could also be obtained in the gasless abdominal wall lift laparoscopic procedure. An immediate preservation of the immune functions in the postoperative period was detected similarly in the 2 groups.
An 11 GHz photonic band gap accelerator structure with wakefield suppression (2004)

We report the design and cold test results for an 11 GHz photonic band gap (PBG) cell, which can be utilized as an accelerator cavity with reduced long-range wakefields. The eigenmodes of the two-dimensional (2D) PBG cavities formed by the defect in a triangular array of metal rods were studied numerically. A 2D PBG cavity with reduced HOM content was designed and built. Cold test results proved the suppression of the higher order modes (HOM) in the PBG cavity. A 6-cell 17.137 GHz PBG accelerator structure is proposed and designed.
Progress in adolescent mental health. (1999)

This chapter reviews the status of emotional and behavioral problems in adolescents and current issues in their assessment and treatment. The authors emphasize the need for the development of mental health programs for adolescents in natural settings such as schools, and present a conceptual framework for intervention based on provider knowledge of risk and protective factors.
Spacecraft charging anomaly on a low-altitude satellite in an aurora (1996)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Dual-beam, light-scattering interferometry for simultaneous measurements of droplet-size and velocity distributions of aerosols from commonly used nebulizers (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDual-beam, light-scattering interferometry for simultaneous measurements of droplet-size and velocity distributions of aerosols from commonly used nebulizersR. H. Clifford, Izumi. Ishii, Akbar. Montaser, and G. A. MeyerCite this: Anal. Chem. 1990, 62, 4, 390–394Publication Date (Print):February 15, 1990Publication History Published online1 May 2002Published inissue 15 February 1990https://pubs.acs.org/doi/10.1021/ac00203a015https://doi.org/10.1021/ac00203a015research-articleACS PublicationsRequest reuse permissionsArticle Views262Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
INTELLIGENT NODES IN DISTRIBUTION SYSTEMS - OPERATING CONCEPT (2007)

Due to gradually increasing loads, medium voltage distribution feeders come closer to their voltage and current limits. Furthermore the introduction of distributed generation (DG) causes larger voltage variations. In this paper a control and protection concept is proposed for so called Intelligent Nodes (INs) applied at medium voltage level. Firstly the control concept is described and illustrated with an example grid. Secondly the reliability impact of the introduction of an IN is analysed and requirements to the protection concept of INs are given.
Session details: Security as a new dimension in embedded system design (2004)

No abstract available.
Predicting Travel Mode of Individuals by Machine Learning (2015)

Travel mode choice prediction of individuals is important in planning new transportation projects. In this paper, we present four machine learning methods namely artificial neural net-MLP, artificial neural net-RBF, multinomial logistic regression, and support vector machines, for predicting travel mode of individuals in city of Luxembourg. The presented methods use individuals’ characteristics, transport mode specifications and data related to places of work and residence. The dataset analyzed comes from a national survey. It contains information on the daily mobility (e.g., from home to work) of individuals who either live or work in Luxembourg. We extracted individual characteristics to relate daily movements (journeys between home and work, in particular) to the characteristics of working individuals. We used the information about public transportation and some geographical location of the residential and work places. We compare the rates of successful prediction obtained by neural networks and several alternative approaches for predicting the travel mode choice using cross-validation. The results show that the artificial neural networks perform better compared to other alternatives. Our analysis can be used to support management decision-making and build predictions under uncertainty related to changes in people's behavior, economic context or environment and transportation infrastructure.
Highly Expandable Foam for Lithographic 3D Printing (2020)

In modern manufacturing, it is a widely accepted limitation that the parts patterned by an additive or subtractive manufacturing process (i.e., a lathe, mill, or 3D printer) must be smaller than the machine itself that produced them. Once such parts are manufactured, they can be postprocessed, fastened together, welded, or adhesively bonded to form larger structures. We have developed a foaming prepolymer resin for lithographic additive manufacturing, which can be expanded after printing to produce parts up to 40× larger than their original volume. This allows for the fabrication of structures significantly larger than the build volume of the 3D printer that produced them. Complex geometries comprised of porous foams have implications in technologically demanding fields such as architecture, aerospace, energy, and biomedicine. This manuscript presents a comprehensive screening process for resin formulations, detailed analysis of printing parameters, and observed mechanical properties of the 3D-printed foams.
Hemocompatibility of Degrading Polymeric Biomaterials: Degradable Polar Hydrophobic Ionic Polyurethane versus Poly(lactic-co-glycolic) Acid (2017)

The use of degradable polymers in vascular tissue regeneration has sparked the need to characterize polymer biocompatibility during degradation. While tissue compatibility has been frequently addressed, studies on polymer hemocompatibility during degradation are limited. The current study evaluated the differences in hemocompatibility (platelet response, complement activation, and coagulation cascade initiation) between as-made and hydrolyzed poly(lactic-co-glycolic) acid (PLGA) and degradable polar hydrophobic ionic polyurethane (D-PHI). Platelet activation decreased (in whole blood) and platelet adhesion decreased (in blood without leukocytes) for degraded versus as-made PLGA. D-PHI showed minimal hemocompatibility changes over degradation. Leukocytes played a major role in mediating platelet activation for samples and controls, as well as influencing platelet-polymer adhesion on the degraded materials. This study demonstrates the importance of assessing the blood compatibility of biomaterials over the course of degradation since the associated changes in surface chemistry and physical state could significantly change biomaterial hemocompatibility.
Evaluation of the PETsys TOFPET2 ASIC in multi-channel coincidence experiments (2021)

Measuring up to the time-of-flight performance of state-of-the-art positron emission tomography (ToF-PET) systems while providing a uniform and stable readout for multiple channels at the same time, the TOFPET2 ASIC is treated as promising candidate for the integration in future ToF-PET systems.
Synthesis and Characterization of Proton Exchange Membrane Using Polystyrene-butadiene Rubber (2010)

Abstract The challenges in proton exchange membrane fuel cell research and development are to reduce the production cost of the fuel cell by reducing the membrane cost. This is possible by the development of an alternative membrane from a cheap source having a good prospect in fuel cell application. Sulphonation of locally available polystyrene butadiene rubber was carried out. The sulphonated polymers were characterized by Fourier transform infrared (FTIR) and nuclear magnetic resonance (HNMR) to verify sulphonation and identify the site available for proton conduction. Thermo gravimetric and differential scanning analyses were also conducted to investigate the thermal stability of the sulphonated polymer. An elemental analyzer was used in analyzing the percentage of sulphur in the sulphonated polymer to determine the ion exchange capacity and degree of sulphonation, while impedance spectroscopy was used to determine the proton conductivity of the synthesized membrane. Results obtained revealed that an increase in weight of polymer reduced the degree of sulphonation while an increase in sulphonation time resulted in an increase in degree of sulphonation. The synthesized membranes in their fully hydrated form were found to have conductivity in the order of 10−3 S/cm, which increases with an increase in temperature and degree of sulphonation. Results of thermal stability further revealed that the synthesized membranes are thermally stable and can be used in high operating temperature fuel cells.
Preparation and study of an epoxy resin based cobalt(II) ion selective electrode using a cobalt(II) complex (2002)

Inorganic Chemistry Division, The Institute of Science, 15 Madam Cama Road, Mumbai 400 032, India <em>E-mail : </em>nvthakkar@ bol .net.in <em>Fax : </em>91-22-2816750 <em>Manuscript received 4 September 2000, revised 2 February 2001, accepted 20 April 2001</em> The preparation and applications of an epoxy resin membrane based Co<sup>ll</sup> ion selective electrode, containing diethyl phthalate (DEP) as plasticizer and impregnated with Co<sup>ll</sup> complex of 1-phenyl-3-methyl-4-benzoy1-5-benzoxypyrazole, have been described. The electrode shows stable potential response in the working range 10<sup>-1</sup> to 10<sup>-5</sup> M of Co<sup>ll</sup> with a slope of 33 mV per decade change in concentration, the response remaining constant in the pH range 3.0-6.0. Optimization of various experimental parameters, in­terference studies and precision and accuracy of the method have been carried out. Usefulness of the cobalt selective electrode has been demonstrated by determination of cobalt in nickel salts and in sea water.
A combined spectrum sensing and terminals localization technique for cognitive radio networks (2012)

Cognitive radio is a smart wireless communication concept that is able to promote the efficiency of the spectrum usage by exploiting its free frequency bands, namely spectrum holes. Detection of spectrum holes is one of the first steps of implementing a cognitive radio system. Another step towards the feasibility and a real implementation of a cognitive radio network is the problem of location awareness. This problem arises when we do consider a realistic scenario in hybrid overlay/underlay systems, when these spectrum opportunities permit cognitive radios to transmit below the primary users tolerance threshold. In this case, the cognitive radio, have to estimate robustly the primary users locations in the network in order to adjust its transmission power function of the estimated location in the network. Adding to this the fact that in wideband radio one may not be able to acquire signals at the Nyquist sampling rate due to the current limitations in Analog-to-Digital Converter (ADC) technology, we end up with a system that should, at a sub-Nyquist rate, properly recover the bands over which the primary users transmit and estimate their location in the network. In this paper 1, we proposed to analyze all these arisen problems. During the problem formulation and when analyzing more deeply the equations related to each question apart, we will make the link between the formulation of spectrum sensing, location awareness and the hardware limitation by describing those problems in a unique compressed sensing formalism. Via the proposed framework, we made it possible to overcame a challenging postulate of fixed frequency spectrum allocation by also estimating the spectrum usage boundaries in a blind way.
A CRIS Data Science Investigation of Scientific Workflows of Agriculture Big Data and its Data Curation Elements (2014)

This joint collaboration between the Purdue Libraries and Cyber Center demonstrates the next generation of computational platforms supporting interdisciplinary collaborative research. Such platforms are necessary for rapid advancements of technology, industry demand and scholarly congruence towards open data, open access, big data and cyber-infrastructure data science training. Our approach will utilize a Discovery Undergraduate Research Investigation effort as a preliminary research means to further joint library and computer science data curation research, tool development and refinement.
Effect of vorinostat (V)-loaded PLGA nanoparticles (NP) surface modified with a PSMA ligand on prostate cancer (PC) cells. (2010)

e13629 Background: Polymeric NP can be tuned for controlled drug delivery and SM for cell-specific targeting. To overcome V concentration and time dependent reversible growth inhibition of PC cells, we designed a NP to deliver V to PC by polymeric NP that were SM with a ligand to prostate specific membrane antigen (PSMA). Methods: V was encapsulated in poly(lactic-co-glycolic acid) (PLGA) using oil in water emulsion. Pegylated (PEG) phospholipid was added to the aqueous phase for SM, electrostatic and steric stabilization, and longer circulation in vivo. For PSMA targeting, the lipid amino end was covalently modified to possess a glutamate urea with known pM Ki binding affinity to PSMA. Four NP designs were used in cytotoxicity assays : (1) V loaded PLGA NP (V-NP), (2) V loaded PLGA NP and PSMA functionalized (V-NP-PSMA), (3) no drug and PSMA functionalized NP (Bk-NP-PSMA), (4) V loaded and unmodified PEG phospholipid (V-NP-DSPE). LNCaP and PC-3 cells (104 /well) were cultured with V (0, 0.1, 0.5, 1, 5, 10, and 100 μM), or equivalent μM concentration of V-NP, V-NP-PSMA, Bk-NP-PSMA, V-NP-DSPE for up to 72hrs. Controlled release (CR) profiles were determined from incubation in PBS, cell proliferation was measured by MTT assay, and IC50 was calculated. Results: NP mean sizes were 110-130nm, and controlled release data show at least 50% release in 7 days and are ongoing. V loading of 9.5 μg V/mg PLGA was improved to over 150μg V/mg PLGA using the PEG phospholipid method. Nonlipid formulations yielded LNCaP IC50 of 8μM, whereas unencapsulated V and functionalized PEG phospholipid formulations yielded IC50 <1μM for LNCaP and PC-3. At 24hrs, V-NP-DSPE showed no cell kill in LNCaP (PSMA+) cells at concentrations of 10μM, whereas V-NP-PSMA did show suppression to less than 80% survival. By 48hrs, 10μM V-NP-PSMA induced complete cell kill compared to 40% survival in the V-NP-DSPE treated group. Conclusions: This novel SM NP design loads a high concentration of V and effective PC cell kill with non-inferior IC50 to unencapsulated drug. Ongoing studies involve characterizing the selective PSMA binding, controlled drug release properties, and optimizing these NP qualities by fraction of PEG phospholipid. No significant financial relationships to disclose.
Biosynthesis of bone sialoprotein by a human osteoclast-like cell line (FLG 29.1) (1995)

Biosynthesis of bone sialoprotein (BSP) by a human osteoclastic cell line (FLG 29.1) during its differentiation induced by phorbol 12-myristate 13-acetate (TPA) was studied using metabolic radiolabeling experiments. The FLG 29.1 cells were metabolically radiolabeled with [3H]glucosamine and [35S]sulfate, and the labeled glycoproteins were analyzed by anion exchange chromatography, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoprecipitation experiments. One of the major glycoproteins synthesized by the TPA-treated FLG 29.1 cells was sulfated, had an identical electrophoretic mobility to purified BSP, and could be immunoprecipitated with a specific antibody against human BSP (LF 6). Thus, this glycoprotein was tentatively identified as the BSP. Furthermore, mRNA for BSP was also detected in TPA-treated FLG 29.1 cells by RNA-polymerase chain reaction. Most BSP synthesized by FLG 29.1 cells remained cell-associated, and this is in contrast with those synthesized by osteoblasts, where the protein is rapidly released into the extracellular matrix. Immunocytochemistry using an anti-BSP antibody showed a prominent paranuclear (suggestive of Golgi apparatus) localization of BSP in the TPA-treated FLG 29.1 cells after permeabilization, while untreated cells were not significantly immunostained. Localization of BSP at the plasma membrane was also demonstrated in the TPA-treated FLG 29.1 cells by the fluorescence-activated cell sorting analysis. Since TPA has been demonstrated to induce expression of various osteoclastic characteristics in FLG 29.1 cells, induction of BSP expression by TPA suggests that the protein may play a role during the differentiation process of osteoclasts or in functions of differentiated osteoclasts.
Design and optimization of new sub-THz compact switch based on 2D photonic crystal with quadrupole resonance in ferrite resonator (2015)

This paper presents the design and optimization of a new switch, based on a two-dimensional photonic crystal with rectangle lattice consisting of a resonant cavity and two waveguides for use in sub-terahertz band. The resonant cavity is based on a ferrite cylinder biased by an external DC magnetic field with a quadrupole mode in the resonator. In order to enlarge the bandwidth of the switch, we applied an optimization procedure by using BOBYQA algorithm for search and optimization of geometrical parameters for the resonant cavity and dielectric rods, as well as the magnetic field intensity.