gebhart/patrepeval huggingface dataset:
Cold-Sintered Temperature Stable Na0.5Bi0.5MoO4–Li2MoO4 Microwave Composite Ceramics (2017)

A cold sintering process (150 °C, 30 min and 200 MPa) was employed to fabricate Na0.5Bi0.5MoO4−Li2MoO4 (NBMO-LMO) composites with up to 96.4% relative density.\nX-ray diffraction traces, backscattered electron images and Raman spectra indicated the coexistence of NBMO and LMO phases in\nall composites with no detectable secondary phases. The pemittivity (εr) and temperature coefficient of resonant frequency (TCF) decreased, whereas microwave quality factor (Q × f) increased, with increasing weight % LMO. Near-zero TCF was obtained for NBMO-20 wt %LMO with εr ∼ 17.4 and Q × f ∼7470 GHz. Functionally graded ceramics were also fabricated with 5 ≤ εr ≤ 24. To illustrate the potential of these cold sintered composites to create new substrates and device architecture, a dielectric graded radial index lens was designed and simulated based on the range of εr facilitated by the NBMO-LMO system,\nwhich suggested a 78% aperture efficiency at 34 GHz.
Evaluation of Immunological Cross‐Reactivity between Clade A9 High‐Risk Human Papillomavirus Types on the Basis of E6‐Specific CD4+Memory T Cell Responses (2010)

CD4(+) T cell responses against the E6 oncoprotein of human papillomavirus (HPV) type 16 and 5 closely related members of clade A9 (HPV31, 33, 35, 52, and 58) were charted in peripheral blood mononuclear cell cultures from healthy subjects and patients who underwent HPV16 E6/E7-specific vaccination. Initial analyses with overlapping peptide arrays showed that approximately one-half of the responding subjects displayed reactivity against corresponding E6 peptides from >or=2 HPV types. This suggested immunological cross-reactivity and complicated retrospective evaluation of the infection history of the healthy subjects. Importantly, further dissection of the response by means of enriched and clonal T cell cultures (with protein antigen instead of peptides) revealed that CD4(+) T cells that are capable of efficiently reacting against E6 antigen from multiple HPV types are rare and only occur when epitope sequences are highly conserved. Our data indicate that natural and vaccine-induced HPV16 E6-specific CD4(+) T cell responses are unlikely to mediate efficient cross-protection against other clade A9 members.
Real-time nonrigid surface detection (2005)

We present a real-time method for detecting deformable surfaces, with no need whatsoever for a priori pose knowledge. Our method starts from a set of wide baseline point matches between an undeformed image of the object and the image in which it is to be detected. The matches are used not only to detect but also to compute a precise mapping from one to the other. The algorithm is robust to large deformations, lighting changes, motion blur, and occlusions. It runs at 10 frames per second on a 2.8 GHz PC and we are not aware of any other published technique that produces similar results. Combining deformable meshes with a well designed robust estimator is key to dealing with the large number of parameters involved in modeling deformable surfaces and rejecting erroneous matches for error rates of up to 95%, which is considerably more than what is required in practice.
Tolerance to Cucumber Mosaic Virus in Pepper: Development of Advanced Breeding Lines and Evaluation of Virus Level (1997)

Tolerance to cucumber mosaic virus (CMV) was introduced from an Indian small-fruited hot pepper accession, Perennial, into several bell-type sweet pepper lines by means of pedigree and backcrossing breeding procedures. Tolerance was determined to be incompletely dominant and quantitatively inherited. Breeding lines with variable degrees of tolerance were developed based on inspection of visual symptoms after mechanical inoculation. The breeding lines were subsequently tested for their agronomic performance in the field after mechanical inoculation. Their levels of tolerance in the field closely resembled their previous performances in the greenhouse. There was no association between virus accumulation levels in the upper leaves, as determined by enzyme-linked immunosorbent assay (ELISA), and the degree of tolerance to the virus, as determined by either visual symptoms or field performance. We concluded that the basis for developing tolerant breeding lines from Perennial is primarily their ability to recover from high virus titer and not their restriction of virus multiplication.
Keeping It Simple: Bio-Inspired Threshold-Based Strain Sensing for Micro-Aerial Vehicles (2021)

Moths use hundreds of strain sensors (campaniform sensilla) on each wing to quickly respond to perturbations that may otherwise destabilize the moth during flight. A similar sensing approach could help stabilize micro-aerial vehicles (MAVs), but large sensor arrays are challenging due to the wiring and large latency that exists when capturing data from many traditional strain sensors. This work introduces a simplified bio-inspired strain sensor; the sensor interface and kinematics were inspired by campaniform sensilla that output a spike only in response to signals of interest. The engineered sensor outputs a discrete analog signal representing strain thresholds. A kinematic model of the sensor design is developed and describes the measured strain in terms of the sensor’s geometric parameters. This model is used to understand trade-offs between sensor resolution and range, and is validated using a finite element model (FEM) of the sensor. The sensor was designed with ease of fabrication in mind, using simple techniques and commercially available components. Fabricated sensors were tested in a four-point flexural test, and the data from the analytical and FEM model show good agreement with the experimental results. The sensors demonstrate resolutions of 83, 158, and 281 microstrain for the different designs tested. A sensor is placed on a model wing to illustrate future applications to MAVs as well as the sensor’s ability to sense both compressive and tensile strains.
Effects of Configuration and Exposure Levels on Responses to Web Advertisements (2003)

International audience
Determination of stress‐induced changes in plasma molecular species by two‐dimensional correlation Fourier transform infrared spectrometry (2004)

For determining exercise-induced changes in plasma molecular species, we investigated the feasibility of using two-dimensional correlation spectra (2D-COS) on 21 series of plasma samples obtained from progressive exercise tests. Intensities of 2D synchronous and asynchronous correlation peaks were compared to concentration evolutions of glucose, lactate, triglycerides (TG), glycerol, fatty acyl moieties, amino acids, proteins, and albumin [determined from plasma Fourier transform infrared (FTIR) spectra] and to performance and training levels of athletes. Synchronous 2D-COS allowed us to determine the linear relationship between protein and fatty acid concentration evolutions as exercise intensity increased (nu1-nu2; 2959 vs 1656 and 1543 cm(-1)). Asynchronous 2D-COS allowed differentiation of fibrinolysis level in subjects during intense exercise, as well as parameters of fatty acid metabolism specifically related either to performance or to training levels. Furthermore, unexpected correlated evolutions of molecular species were highlighted by this method, showing that 2D spectrometry may also be used for experimental investigations on human physiology. This study has demonstrated that 2D-COS may be used for the treatment of complex biological samples, such as plasma.
Prepubertal Diagnosis of Steroid 5α-Reductase Deficiency* (1978)

The diagnosis of 5 alpha-reductase deficiency was proven in two prepubertal patients with male pseudohermaphroditism (MPH). Both had a 46-XY karyotype and were reared as females; one child had been castrated in infancy. Clitoromegaly, urogenital sinus, and short vaginal pouch were present in both; inguinal gonads were palpable in one. The diagnosis was made biochemically by observing characteristic changes in five parameters: 1) abnormally high testosterone to dihydrotestosterone (T:DHT) ratio after hCG stimulation (35 and 53 vs. normal, 11 +/- 3), 2) abnormally high 5 beta-T metabolites in urine (8.1 and 6.0 vs. normal, less than 1),3) deficient conversion of T to DHT during [3H] T infusion (0.3 and 0.4% vs. normal, 5.3 +/- 3), 4) deficient conversion of [14 C] T to 5 alpha-reduced metabolites by nongenital skin fibroblasts (2.2 and 1.9 pmol/microgram DNA/nmol substrate vs. 68.4+/- 7.8 Pmol/microgram DNA/nmol substrate in normal controls), and 5) deficient conversion of [14C]T to DHT in genital skin slices. The fact that this syndrome represents a defect in T metabolism rather in in T binding is demonstrated by the observation that binding of [3H]DHT to cytosol of skin fibroblasts was normal (4.2 dpm/micrograms DNA vs. normal male values of 3.7 +/- 0.64). Thus, the present report suggests that 5 alpha-reductase deficiency can be diagnosed during childhood and even after castration by metabolic studies of nongenital skin fibroblasts and determination of the conversion ratio of [3H]T to [3H]DHT in plasma.
Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies (2022)

sCD137 in plasma and CD137 surface expression can be used as quantitative parameters dynamically reflecting therapeutic costimulatory activity elicited by agonist CD137-targeted agents.
Multiple CD11c+ Cells Collaboratively Express IL-1β To Modulate Stromal Vascular Endothelial Growth Factor and Lymph Node Vascular–Stromal Growth (2014)

Lymphadenopathy in autoimmune and other lymphoproliferative diseases is in part characterized by immunoblasts and vascular proliferation. The lymph node vasculature, along with the nonvascular stromal compartment, supports lymphocyte function, and targeting vascular-stromal expansion in inflamed nodes may modulate lymphocyte function in disease. CD11c(+) cells are essential for vascular-stromal proliferation and the upregulation of vascular endothelial growth factor (VEGF) needed for vascular proliferation. However, targetable CD11c(+) cell-derived molecular mediators, the identity of relevant CD11c(+) cells, and whether CD11c(+) cells directly stimulate VEGF-expressing stromal cells are poorly understood. In this study we show that CD11c(+) CD11b(+) CCR2-dependent monocytes and CCR7-dependent dendritic cells express IL-1β. IL-1β blockade, IL-1β deficiency in radiosensitive cells, and CCR2/CCR7 double deficiency but not single deficiency all attenuate immunization-induced vascular-stromal proliferation. gp38(+) stromal fibroblastic reticular cells (FRCs) that express VEGF are enriched for Thy1(+) cells and partially overlap with CCL21-expressing FRCs, and FRC VEGF is attenuated with IL-1β deficiency or blockade. IL-1β localizes to the outer borders of the T zone, where VEGF-expressing cells are also enriched. Ex vivo, CD11b(+) cells enriched for IL-1β(+) cells can directly induce cultured gp38(+)Thy1(+) FRCs to upregulate VEGF. Taken together, these results suggest a mechanism whereby multiple recruited CD11c(+) populations express IL-1β and directly modulate FRC function to help promote the initiation of vascular-stromal growth in stimulated lymph nodes. These data provide new insight into how CD11c(+) cells regulate the lymph node vascular-stromal compartment, add to the evolving understanding of functional stromal subsets, and suggest a possible utility for IL-1β blockade in preventing inflammatory lymph node growth.
Integrated SAR /GPS / INS for Target Geolocation Improvement (2014)

A big percentage of military men and policy of scientific research aims in the sector of technology of fusion of sensors. However, up to now there has been a little progress in the fusion study of Radar sensors with Synthetic Diaphragm (Synthetic Aperture Radar sensors (SARS)) and Pilotage Sensors. As indicative examples, one can state the sensors of inactive pilotage (Inertial Navigation Sensors (INS)), as well as the systems of world localization (Global Positioning System (GPS)). SARS are used in recognition operations and pursuit. The received SAR scope and measurement rate are processed independently from the system of pilotage. This work investigates a likely technique for the fusion of information from the pilotage sensors and the measurements of objectives SAR. An incorporated system INS/GPS/SAR is simulated through a Kalman filter, and the SAR profits of geolocation precision objectives are analyzed. Three different models of GPS are used. Each GPS model is incorporated in a common INS/SAR combination aiming at the improvement of geolocation precision objectives. The obtained results show that the pursuit with use of SAR can be strengthened, via the conformity of unification of an INS/GPS pilotage system, without any increase of SAR analysis.
Introduction to the Special Issue: Role of General Mental Ability in Industrial, Work, and Organizational Psychology (2002)

Project management has an important role to play in terms of understanding the client’s business as well as the project objectives and incorporating these in the design, method and sequence of the finished construction. An integrated approach is ideally one that draws the client, designer and contractors into a virtual organisation that is able to effectively share information and ideas to produce an optimum and efficient solution regardless of market conditions. Sustainable buildings are achieved by integrating strategies for design, delivery and building use. The project manager is responsible for directing the project for its entire duration and formally starts up the project by producing the risk log and the project brief, initiating a project team and outlining a plan for the initiation stage. The planning process is product based and determines the products needed, their content and their sequencing.
CORBA-based speech-to-speech translation system (2005)

We describe the new implementation of a speech-to-speech translation system at ATR Spoken Language Translation Research Laboratories (SLT). We use the architecture standard CORBA (Common Object Request Broker Architecture) to interface between a speech recognizer, translation system and TTS engine. Various input types are supported, including close-talking microphone and telephony hardware.
Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells. (1987)

Treatment of HL-60 cells with dibutyryl cyclic AMP induced rapid transcriptional inactivation of c-myc and the transferrin receptor. Transcriptional inactivation was followed by loss of c-myc and transferrin receptor mRNA and protein. Treated cells completed one round of proliferation, followed by growth arrest, G1 synchronization, and monocytic differentiation. These data suggest that cyclic AMP-mediated control of growth and differentiation may be achieved, at least in part, by transcriptional regulation of certain growth-associated proto-oncogenes and growth factor receptor genes.
Guest Editorial Special Issue on the 2020 ISICAS: A CAS Journal Track Symposium (2020)

The papers in this special issue were presented at the virtual 2020 International Symposium on Integrated Circuits and Systems (ISICAS).
Prospective Clinical and Fiberoptic Evaluation of the Supreme Laryngeal Mask Airway ™ (2009)

Clinical evaluation of the LMA Supreme showed easy insertion, optimal laryngeal fit, and low airway morbidity. Oropharyngeal leak pressure results were comparable to earlier data from the LMA ProSeal.
Health economics: can we afford an unrestricted use of new biological agents in gastrointestinal oncology? (2005)

There are many new promising (biologic) agents available for patients with gastrointestinal cancer. The availability of these drugs for patients becomes more and more dependent on economic reasons.
Re: Robotic Partial Nephrectomy with Superselective versus Main Artery Clamping: A Retrospective Comparison (2015)

No AccessJournal of UrologyAdult Urology1 May 2015Re: Robotic Partial Nephrectomy with Superselective versus Main Artery Clamping: A Retrospective Comparison Jeffrey A. CadedduMD Jeffrey A. CadedduJeffrey A. Cadeddu More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.01.105AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Robotic Partial Nephrectomy with Superselective versus Main Artery Clamping: A Retrospective Comparison." The Journal of Urology, 193(5), pp. 1516–1517 © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193 Issue 5 May 2015 Page: 1516-1517 Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.Metrics Author Information Jeffrey A. Cadeddu More articles by this author Expand All Advertisement PDF downloadLoading ...
Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy (2022)

Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is characterized by unexplained segmental hypertrophy that is usually most pronounced in the septum. While sarcomeric gene mutations are often the genetic basis for HCM, the mechanistic origin for the heterogeneous remodeling remains largely unknown. A better understanding of the gene networks driving the cardiomyocyte (CM) hypertrophy is required to improve therapeutic strategies. Patients suffering from HCM often receive a septal myectomy surgery to relieve outflow tract obstruction due to hypertrophy. Using single-cell RNA sequencing (scRNA-seq) on septal myectomy samples from patients with HCM, we identify functional links between genes, transcription factors, and cell size relevant for HCM. The data show the utility of using scRNA-seq on the human hypertrophic heart, highlight CM heterogeneity, and provide a wealth of insights into molecular events involved in HCM that can eventually contribute to the development of enhanced therapies.
Area efficient decoding of quasi-cyclic low density parity check codes (2004)

This paper exploits the similarity between the two stages of belief propagation decoding algorithm for low density parity check codes to derive an area efficient design that re-maps the check node functional units and variable node functional units into the same hardware. Consequently, the novel approach could reduce the logic core size by approximately 21% without any performance degradation. In addition, the proposed approach improves the hardware utilization efficiency as well.
Tutorial on storage technology (1995)

In stark contrast to the 25% per year increase in areal density delivered by the magnetic disk industry during the 1970s and 1980s, yearly increases today are 60%, on par with DRAM density increases. Moreover, the storage industry is also delivering substantially higher data rates, smart disk-embedded readahead and writebehind, and a new generation of high-speed serial interconnects. This industry has also embraced Redundant Arrays of Inexpensive (or Independent) Disks (RAID) technology - 1997's RAID market is expected to be 13 billion dollars. With this rapidly evolving market and technology base, parallel storage systems must evolve beyond RAID levels 1 through 5. This talk is intended for researchers and practitioners interested in current trends in storage systems. It will highlight storage technology trends, RAID technology trends, and trends toward RAID-style support for network-based parallel storage systems.
White Matter Tract Integrity: An Indicator of Axonal Pathology after Mild Traumatic Brain Injury (2017)

We seek to elucidate the underlying pathophysiology of injury sustained after mild traumatic brain injury (mTBI) using multi-shell diffusion magnetic resonance imaging, deriving compartment-specific white matter tract integrity (WMTI) metrics. WMTI allows a more biophysical interpretation of white matter (WM) changes by describing microstructural characteristics in both intra- and extra-axonal environments. Thirty-two patients with mTBI within 30 days of injury and 21 age- and sex-matched controls were imaged on a 3 Tesla magnetic resonance scanner. Multi-shell diffusion acquisition was performed with five b-values (250-2500 sec/mm<sup>2</sup>) along 6-60 diffusion encoding directions. Tract-based spatial statistics (TBSS) was used with family-wise error (FWE) correction for multiple comparisons. TBSS results demonstrated focally lower intra-axonal diffusivity (D<sub>axon</sub>) in mTBI patients in the splenium of the corpus callosum (sCC; p < 0.05, FWE-corrected). The area under the curve value for D<sub>axon</sub> was 0.76 with a low sensitivity of 46.9% but 100% specificity. These results indicate that D<sub>axon</sub> may be a useful imaging biomarker highly specific for mTBI-related WM injury. The observed decrease in D<sub>axon</sub> suggests restriction of the diffusion along the axons occurring shortly after injury.
Water Availability Coincides with Population Declines for an Endangered Butterfly (2018)

As global climate change causes population declines across numerous taxa, it becomes critical to understand the specific pathway by which climatic and anthropogenic factors influence population size. Water availability is a key environmental condition that links climate and humans to species response, especially for rare or threatened butterflies that are highly sensitive to changes in climate and the surrounding landscape. We use the wetland-dependent endangered St. Francis’ satyr butterfly (Neonympha mitchellii francisci) to test how changes in water availability affect population size via changes in host plant growth. We show that long-term declines in water availability are directly linked to a decline in host plant growth and contributed to a population decrease of 95% for St. Francis’ satyrs in the past decade, threatening the persistence of the species. Recent restoration work, which includes efforts to increase water availability via hardwood removal, has been successful in increasing population numbers. Many butterflies are broadly dependent on water availability and flow, and only by understanding the specific pathway that directly links water availability to species response can we make effective conservation plans to prepare for the altered water conditions of the future.
ChemInform Abstract: A Concise Synthetic Route to Polyfunctional γ‐Ketoester Derivatives via Methoxy(phenylthio)methyl‐lithium. (1986)

Abstract Die aus dem lithiierten O,S‐Acetal (IV) zugänglichen Acetale (VI) und (VIII) werden in die Alkylierungsprodukte (IX)‐(XI) bzw. in (XII) übergeführt.
Error Estimates of the Ares I Computed Turbulent Ascent Longitudinal Aerodynamic Analysis (2012)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.