gebhart/patrepeval huggingface dataset:
Spatial-Aware Object Embeddings for Zero-Shot Localization and Classification of Actions (2017)

We aim for zero-shot localization and classification of human actions in video. Where traditional approaches rely on global attribute or object classification scores for their zero-shot knowledge transfer, our main contribution is a spatial-aware object embedding. To arrive at spatial awareness, we build our embedding on top of freely available actor and object detectors. Relevance of objects is determined in a word embedding space and further enforced with estimated spatial preferences. Besides local object awareness, we also embed global object awareness into our embedding to maximize actor and object interaction. Finally, we exploit the object positions and sizes in the spatial-aware embedding to demonstrate a new spatiotemporal action retrieval scenario with composite queries. Action localization and classification experiments on four contemporary action video datasets support our proposal. Apart from state-of-the-art results in the zero-shot localization and classification settings, our spatial-aware embedding is even competitive with recent supervised action localization alternatives.
Cytomegalovirus Infection in Pediatric Renal Transplant Recipients: A Single Center Experience (2017)

Purpose: To investigate the frequency, presentation, management, and outcome of cytomegalovirus (CMV) infection in pediatric patients who underwent renal transplantation. Methods: We performed a retrospective chart review of 70 patients under the age of 18, who underwent renal transplantation between January 1990 and November 2014. A diagnosis of CMV infection was based on serology, molecular assays, antigenemia assays, and culture. CMV infection was defined as detection of virus and CMV disease was diagnosed when clinical signs and symptoms were present.
In silico screening of molecular imprinting prepolymerization systems: oseltamivir selective polymers through full-system molecular dynamics-based studies (2016)

All-component molecular dynamics studies were used to probe a library of oseltamivir molecularly imprinted polymer prepolymerization mixtures. Polymers included one of five functional monomers (acrylamide, hydroxyethylmethacrylate, methacrylic acid, 2-(triflouromethyl)acrylic acid, 4-vinylpyridine) and one of three porogens (acetonitrile, chloroform, methanol) combined with the crosslinking agent ethylene glycol dimethacrylate and initiator 2,2'-azobis(2-methylpropionitrile). Polymers were characterized by nitrogen gas sorption measurements and SEM, and affinity studies performed using radioligand binding in various media. In agreement with the predictions made from the simulations, polymers prepared in acetonitrile using either methacrylic or trifluoromethacrylic acid demonstrated the highest affinities for oseltamivir. Further, the ensemble of interactions observed in the methanol system provided an explanation for the morphology of polymers prepared in this solvent. The materials developed here offer potential for use in solid-phase extraction or for catalysis. The results illustrate the strength of this in silico strategy as a potential prognostic tool in molecularly imprinted polymer design.
A surprisingly simple technique to control the pretraining bias for better transfer: Expand or Narrow your representation (2023)

Self-Supervised Learning (SSL) models rely on a pretext task to learn representations. Because this pretext task differs from the downstream tasks used to evaluate the performance of these models, there is an inherent misalignment or pretraining bias. A commonly used trick in SSL, shown to make deep networks more robust to such bias, is the addition of a small projector (usually a 2 or 3 layer multi-layer perceptron) on top of a backbone network during training. In contrast to previous work that studied the impact of the projector architecture, we here focus on a simpler, yet overlooked lever to control the information in the backbone representation. We show that merely changing its dimensionality -- by changing only the size of the backbone's very last block -- is a remarkably effective technique to mitigate the pretraining bias. It significantly improves downstream transfer performance for both Self-Supervised and Supervised pretrained models.
Epidermal Growth Factor (EGF) induces a phenotypic switch of a human glioblastoma cell line to neurospheres (2002)

Journal Article Epidermal Growth Factor (EGF) induces a phenotypic switch of a human glioblastoma cell line to neurospheres Get access T Bargar, T Bargar Dept. Cell Biology and Anatomy, Univ. Nebraska Med. Ctr. (UNMC), Omaha, NE 68198-6395 Search for other works by this author on: Oxford Academic Google Scholar T Bargar, T Bargar Dept. Cell Biology and Anatomy, Univ. Nebraska Med. Ctr. (UNMC), Omaha, NE 68198-6395 Search for other works by this author on: Oxford Academic Google Scholar I Ahmad, I Ahmad Dept. Ophthalmology, UNMC, Omaha, NE 68198-7691 Search for other works by this author on: Oxford Academic Google Scholar M Ebadi, M Ebadi Dept. Pharmacology and Toxicology, Univ. North Dakota, Grand Forks, ND 58202-9037 Search for other works by this author on: Oxford Academic Google Scholar J Rodriguez-Sierra J Rodriguez-Sierra Dept. Cell Biology and Anatomy, Univ. Nebraska Med. Ctr. (UNMC), Omaha, NE 68198-6395 Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 8, Issue S02, 1 August 2002, Pages 1012–1013, https://doi.org/10.1017/S143192760210688X Published: 01 August 2002
Real-Time Operando Diffraction Imaging of La–Sr/CaO During the Oxidative Coupling of Methane (2018)

An La–Sr/CaO catalyst has been chemically imaged during activation and under operando conditions during the oxidative coupling of methane reaction (OCM) at high temperature using X-ray diffraction computed tomography (XRD-CT) in combination with full pattern Rietveld refinement. At room temperature the main components of the catalyst were present as carbonates and hydroxides. During the activation stage (temperature ramp) they decomposed, forming La2O3, SrO, and mixed CaO–SrO oxides. Under the OCM reaction conditions, the predominant phases present were (∼20% wt) La2O3 and CaO-SrO (∼45% wt), and these remained stable throughout the entire reaction, whereas SrO, formed during activation, reacted with produced CO2 leading to formation of SrCO3 (∼35% wt). Two polymorphs of SrCO3, orthorhombic and rhombohedral, were found to be stable under reaction conditions although the extent to which these phases were observed varied spatially and temporally with reactant gas composition. The presence of the high temperature rhombohedral polymorph can be associated with higher combustion activity, and since the Rietveld analysis is performed on a pixel-by-pixel basis, it is possible to observe, for the first time, domains of differing activity within the reactor.
ChemInform Abstract: Photochemical Rearrangement of N‐Chlorolactams: A Route to N‐Heterocycles Through Concerted Ring Contraction. (2010)

Abstract Upon irradiation 6‐ and 7‐membered N‐chlorolactams are found to undergo novel ring contraction yielding pyrrolidine or piperidine derivatives.
HGG-26. H3G34V MUTATION AFFECTS GENOMIC H3K36 METHYLATION IN PEDIATRIC GLIOMA (2020)

Abstract BACKGROUND Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V), impairing SETD2 activity (H3K36-specific trimethyltransferase), resulting in reduced H3K36me on H3G34V nucleosomes relative to wild-type. This contributes to genomic instability and drives distinct gene expressions associated with tumorigenesis. However, it is not known if this differential H3K36me3 enrichment is due to H3G34V mutant protein alone. Therefore, we set to elucidate the effect of H3G34V on genomic H3K36me3 enrichment in vitro. METHODS Doxycycline-inducible short hairpin RNA (shRNA) against H3F3A was delivered via lentivirus to established H3G34V mutant pediatric glioma cell line KNS42, and H3G34V introduced into H3.3 wild type normal human astrocytes (NHA). Transfections were confirmed by western blot, fluorescent imaging, and flow cytometry, with resulting H3.3WT and H3K36me3 expression determined by western blot. H3.3WT, H3K36me3, and H3G34V ChIP-Seq was performed to evaluate genomic enrichment. RESULTS Complete knockdown of H3G34V was achieved with DOX-induced shRNA, with no change in total H3.3, suggesting disproportionate allelic frequency of genes encoding H3.3 (H3F3A and H3F3B). Modest increase in H3K36me3 occurred after H3F3A-knockdown from KNS42, suggesting H3G34V alone impacts observed H3K36me3 levels. Distinct H3K36me3 genomic enrichment was observed with H3G34V knock-in. CONCLUSIONS We demonstrate that DOX-inducible knockdown of H3F3A in an H3G34V mutant pediatric glioma cells and H3G34V mutation transduction in wild-type astrocytes affects H3K36me3 expression. Further evaluation by ChIP-Seq analysis for restoration of wild-type genomic H3K36me3 enrichment patterns with H3G34V knockdown, and mutant H3K36me3 patterns with H3G34V transduction, is currently underway.
High‐concentration cultivation of Lactococcus cremoris in a cell‐recycle reactor (1991)

High-cell concentration cultivation of Lactococcus cremoris, a homofermentative lactic acid producer, in a cell-recycle fermentor is described. Cross-flow filtration allowing continuous removal of the inhibitory metabolite, the influence of dilution rate on growth was investigated in total or partial cell-recycle cultures. The dependence of growth characteristics on operating conditions was identified and quantified using lactose as the carbon source. Growth kinetics could be described by both lactate removal efficiency and nutrient availability. Based on physiological observations, biomass and lactic acid productivities were predicted in partial cell-recycle cultures.
Optimizing the Lifetime of Sensor Networks with Uncontrollable Mobile Sinks and QoS Constraints (2016)

In past literature, it has been demonstrated that the use of mobile sinks (MSs) increases dramatically the lifetime of wireless sensor networks (WSNs). In applications where the MSs are humans, animals, or transportation systems, the mobility of the MSs is often uncontrollable and could also be random and unpredictable. This implies the necessity of algorithms tailored to handle uncertainty on the MS mobility. In this article, we define the lifetime optimization of a WSN in the presence of uncontrollable sink mobility and Quality of Service (QoS) constraints. After defining an ideal scheme (called Oracle ) which provably maximizes network lifetime, we present a novel Swarm-Intelligence-based Sensor Selection Algorithm (SISSA), which optimizes network lifetime and meets predefined QoS constraints. Then we mathematically analyze SISSA and derive analytical bounds on energy consumption, number of messages exchanged, and convergence time. The algorithm is experimentally evaluated on practical experimental setups, and its performances are compared to that by the optimal Oracle scheme, as well as with the IEEE 802.15.4 MAC and TDMA schemes. Results conclude that SISSA provides on the average the 56% of the lifetime provided by Oracle and outperforms IEEE 802.15.4 and TDMA in terms of yielded network lifetime.
A Dominant-negative Mutant of Human DNA Helicase B Blocks the Onset of Chromosomal DNA Replication (2002)

A cDNA encoding a human ortholog of mouse DNA helicase B, which may play a role in DNA replication, has been cloned and expressed as a recombinant protein. The predicted human DNA helicase B (HDHB) protein contains conserved helicase motifs (superfamily 1) that are strikingly similar to those of bacterial recD and T4 dda proteins. The HDHB gene is expressed at low levels in liver, spleen, kidney, and brain and at higher levels in testis and thymus. Purified recombinant HDHB hydrolyzed ATP and dATP in the presence of single-stranded DNA, displayed robust 5'-3' DNA helicase activity, and interacted physically and functionally with DNA polymerase alpha-primase. HDHB proteins with mutations in the Walker A or B motif lacked ATPase and helicase activity but retained the ability to interact with DNA polymerase alpha-primase, suggesting that the mutants might be dominant over endogenous HDHB in human cells. When purified HDHB protein was microinjected into the nucleus of cells in early G(1), the mutant proteins inhibited DNA synthesis, whereas the wild type protein had no effect. Injection of wild type or mutant protein into cells at G(1)/S did not prevent DNA synthesis. The results suggest that HDHB function is required for S phase entry.
Real-time infrared and semi-active laser scene generation software for AMSTAR hardware in the loop (2005)

This paper describes the current research and development of advanced scene generation technology for integration into the Advanced Multispectral Simulation Test and Acceptance Resource (AMSTAR) Hardware-in-the-Loop (HWIL) facilities at the US Army AMRDEC and US Army Redstone Technical Test Center at Redstone Arsenal, AL. A real-time multi-mode (infra-red (IR) and semi-active laser (SAL)) scene generator for a tactical sensor system has been developed leveraging COTS hardware and open source software (OSS). A modular, plug-in architecture has been developed that supports rapid reconfiguration to permit the use of a variety of state data input sources, geometric model formats, and signature and material databases. The platform-independent software yields a cost-effective upgrade path to integrate best-of-breed personal computer (PC) graphics processing unit (GPU) technology.
ARGININE DECARBOXYLASE IMMOBILIZATION (1980)

ABSTRACT Arginine decarboxylase was immobilized by (1) glutaraldehyde crosslinking to form a gel, (2) chemical coupling to a glutaraldehyde derivative of alkylaminopropyl glass, or (3) chemical coupling to succinamidopropyl glass beads. Enzyme activity was tested by either the enzyme electrode system or enzyme reactor system. Covalent coupling to alkylaminopropyl glass appeared to be the best immobilization procedure. The best detection procedure was the enzyme reactor (linear range 3 × 10 −4 to 3 × 10 −3 M, linear equation mV = 53.43 log[Arg] + 226.38). Equilibrium was attained in 4–6 min with the enzyme reactor.
Radiation Exposure with Use of the Mini-C-Arm for Routine Orthopaedic Imaging Procedures (2005)

The mini-c-arm device should be utilized whenever feasible in order to eliminate many of the concerns associated with use of the large c-arm device, specifically those related to cumulative radiation hazards, positioning considerations, relative distance from the beam, and the need for protective shielding.
Compressed Transmission Mode: An Optimizing Decision Tool. (1994)

In this paper we address the problem of host to host communication. In particular, we discuss the issue of efficient and adaptive transmission mechanisms over possible physical links. We develop a tool for making decisions regarding the flow of control sequences and data from and to a host. The issue of compression is discussed in details, a decision box and an optimizing tool for finding the appropriate thresholds for a decision are developed. Physical parameters like the data rate, bandwidth of the communication medium, distance between the hosts, band rate, levels of discretization, signal to noise ratio and propagation speed of the signal are taken into consideration while developing our decision system. Theoretical analysis is performed to develop mathematical models for the optimization algorithm. Simulation models are also developed for testing both the optimization and the decision tool box.
Electroplating of Multiple Materials in Parallel Using Patterned Gels with Applications in Electrochemical Sensing (2020)

Electrodeposition is a versatile technique for the fabrication of electrodes in micro-electroanalytical devices. Conductive but low-cost materials, such as copper, can be coated with functional yet higher-cost materials such as gold or silver using electrodeposition to lower the overall cost while maintaining functionality. When the electrodeposition of multiple materials is required, current methods use a multistep process that deposits one material at a time, which requires a significant amount of time and a significant number of steps. Additionally, they use a large volume of electrolytes suitable for coating large objects, which is wasteful and unnecessary for the prototyping or coating of microelectrodes with a small area. In this paper, a new method of electroplating is introduced in which we used gels to immobilize and pattern electroplating electrolytes on a substrate surface. Agarose, as an immobilizing medium, enables the immersion of the substrate in a common working electrolyte without cross-mixing different electrolytes. We demonstrate the printing of jelly electrolytes by using spot-dispensing or microfluidic flow. Xurographically patterned films laminated on the substrate function as a mask and confine the printed gels to desired locations. After printing, the substrate is placed in a common working electrolyte container, and multimaterial patterns are produced through the application of an electrical current in a single step.
Molecular Size Determination of Coal-Derived Asphaltene by Fluorescence Correlation Spectroscopy (2011)

The molecular properties of asphaltenes have been the subject of uncertainty in the literature; in particular the molecular architecture is still a matter of debate. Some literature reports provide evidence that the contrast of petroleum asphaltenes versus coal-derived asphaltenes is useful for understanding the governing principles of asphaltene identity. Here, we employ fluorescence correlation spectroscopy to measure the diffusion constants of asphaltenes obtained from the distillation resid from coal liquefaction fluids. Concentrations employed herein are ∼10 −8 molar, precluding asphaltene aggregation. These are compared with the same measurements on petroleum asphaltenes. These results confirm that the molecular sizes of these coal-derived asphaltenes are much smaller than virgin petroleum asphaltenes. Coal-derived asphaltenes are simpler than petroleum asphaltenes and provide correspondingly tighter constraints for understanding asphaltene molecular architecture. The small size, small alkane fraction, and large PAH of coal-derived asphaltenes are consistent with an “island” molecular architecture.
Significance of the HV interval in 517 patients with chronic bifascicular block. (1981)

In January 1975, we reported results of a prospective follow-up study (mean 538 +/- 42 days) of 119 patients with chronic bifascicular block (BFB), and concluded that BFB patients with normal and prolonged HV (NHV and PHV) had a similar incidence of atrioventricular (AV) block and mortality. In this report, we update these findings in 517 patients with a follow-up of 21 days to 9.8 years (mean 3.4 +/- 0.2 years). Three hundred nineteen patients (61%) had NHV and 198 (39%) had PHV (greater than 55 msec). The NHV and PHV groups were similar in regard to age (NHV vs PHV, 61 +/- 1 vs 62 +/- 1 years) and sex (80% male, 20% female vs 82% male and 18% female). The following were more common (p less than 0.05) in patients with PHV (percent of patients with finding in NHV vs PHV groups): angina (18% vs 27%), congestive failure (27% vs 42%), cardiomegaly (48% vs 66%), New York Heart Association functional class II-IV (34% vs 56%), premature ventricular complexes (20% vs 29%), and organic heart disease (OHD) (75% vs 85%). Spontaneous trifascicular block (TFB) developed in two patients (0.6%) with NHV and nine patients (4.5%) with PHV (p less than 0.05). Cumulative 7-year incidence of TFB was 3% with NHV and 12% with PHV (p less than 0.01). Seven-year cumulative cardiovascular mortality was 32% in NHV patients and 57% in PHV patients (p less than 0.005). In conclusion, PHV in patients with chronic BFB was associated with a greater incidence and severity of OHD, and higher total and sudden death mortalities. The risk of spontaneous TFB was small in patients with either NHV or PHV, although it was significantly higher in the latter.
A new automated method for reliable speaker identification and verification over telephone channels (2005)

Notwithstanding the wide use of fully automatic method of feature extraction in speaker identification/verification tasks, based mainly on LPC, cepstrum and spectral band techniques, a recent work [1] by the authors demonstrated that in forensic applications semiautomatic, operator-assisted feature extraction procedures are more reliable. The drawbacks of a semiautomatic parameters extraction is either on the loss of real time or in the dipendence of the system performance on the skilled operator contribution. The proposed method of automatic parametrization of the speech signals seems to resolve these problems. Given the speech signal defined as a single realization of the speaker's voice, an automatic vowel identifier based on energy, pitch and cepstrum information provides the first segmentation. Then a formant trajectories tracer is operated and a rule-based system selects the suitable and stable frames on the vowels avoiding double sounds and transients. The restricted population of vowel-like sound frames is then subjected to a clustering procedure on the F1/F2 plane when all the a-priori knowledge on the vowel sounds is a guide to select the best five clusters to assign to the five Italian vowels. After the vectorization of the whole talker set and of the unknown veices, if any, the Bayes classifier is invoked and the proper decision tests are performed. The results of this automated extraction/decision sequence are presented in the paper with comparison to the oparator dependent procedure.
Humanized Mouse Model Used to Monitor MUC Gene Expression in Nasal Polyps and to Preclinically Evaluate the Efficacy of Montelukast in Reducing Mucus Production (2012)

The use of innate and adaptive immunodeficient NOD-scid mice homozygous for targeted mutations in the IL-2 gamma-chain locus NOD-scid IL-2r gamma(null) for establishing engraftment of nondisrupted pieces of human nasal polyp tissues represents a significant advancement in studying chronic inflammation over a long period of time. In the present study, we utilized this humanized mouse model to confirm our prediction that MUC genes 4 and 5AC are highly expressed and significantly increased over those of preimplanted polyps. The overexpression of these 2 MUC genes correlates with both the goblet cell hyperplasia and the excessive mucus production that are found in nasal polyp xenografts. MUC7, which is primarily associated with the submucosa, as opposed to MUC4 and MUC5AC, which are primarily expressed in the epithelium, was significantly decreased in the nasal polyp xenografts. Montelukast had no significant effect on MUC gene expression in the xenografts. In addition to the MUC gene expression patterns, the histology of the xenografts supports the concept that mucinous glands that are characteristic of true nasal polyps are significantly different from those in the mucosa found in the lateral wall of the nose in patients with chronic sinusitis without nasal polyps. The mucinous glands seen in nasal polyps (which appear to be derived from an invagination of hyperplastic epithelial mucosa containing large numbers of goblet cells) are histologically distinct from the seromucinous glands found in the submucosa of hyperplastic middle turbinates. The data presented here establish a humanized mouse model as a viable approach to study nasal polyp growth, to assess the therapeutic efficacy of various drugs in this chronic inflammatory disease, and to contribute to our understanding of the pathogenesis of this disease.