gebhart/patrepeval huggingface dataset:
Peptide binding to metal oxide nanoparticles (2017)

Magnetic metal oxide nanoparticles demonstrate great applicability in several fields such as biotechnology, medicine and catalysis. A stable, magnetic and low-cost material, nanoscale magnetite, is an interesting adsorbent for protein purification. Downstream processing can account for up to 80% of the total production costs in biotechnological production. As such, the development of new innovative separation methods can be regarded as highly profitable. While short peptide sequences can be used as specific affinity tags for functionalised adsorber surfaces, they need expensive affinity ligands on the particle surface for adsorption. In order to identify peptide tags for several non-functionalised inorganic surfaces, different binding conditions to iron oxide nanoparticles are evaluated. Therefore, magnetite nanoparticles in a range of 5-20 nm were synthesised with a co-precipitation method. Zeta potential measurements indicated an amphiphilic surface with an isoelectric point in the neutral pH region. Glutamic acid-based homo-peptides were used as affinity peptides for the magnetite nanoparticles. We demonstrate a dependence of the binding affinity of the peptides on pH and buffer ions in two different experimental set-ups. The nature of surface coordination for glutamic acid-based peptides can be demonstrated with different spectroscopic approaches such as infrared spectroscopy (IR), Raman spectroscopy and circular dichroism spectroscopy (CD). We want to emphasise the importance of physicochemical properties such as surface energy, polarity, morphology and charge. These parameters, which are dependent on the environmental conditions, play a crucial role in peptide interactions with iron oxide surfaces. The understanding of the adsorption of simple biomolecules on nanoscale metal oxide surfaces also represents the key to the even more complex interactions of proteins at the bio-nano interface. From the identification of interaction patterns and an understanding of the adsorption of these peptides, the up-scaling to tagged model proteins facilitates the possibility of an industrial magnetic separation process and might therefore reduce time and costs in purification processes.
Imaging Detectors for 20-100 ke V X-ray Backlighters in HEDES Petawatt Experiments (2004)

We are developing a petawatt laser for use as a high energy backlighter source in the 20{approx} 100 keV range. High energy x-ray backlighters will be essential for radiographing High-Energy- Density Experimental Science (HEDES) targets for NIF projects especially to probe implosions and high areal density planar samples. For these experiments we are employing two types of detectors: a columnar grown CsI scintillator coupled to a 2K x 2K CCD camera and a CdTe crystal with a special ASIC readout electronics in a 508 x 512 format array. We have characterized these sensors using radioactive sources. In addition, we utilized them to measure the Sm K{alpha} source size generated by the short pulse laser, JanUSP, at LLNL. This paper will present the results of our characterizations of these detectors.
Antimitotic and Cytotoxic Flavonols from Zieridium pseudobtusifolium and Acronychia porteri (1994)

Bioassay-guided fractionation of the extracts of Zieridium pseudobtusifolium and Acronychia porteri led to the isolation of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone [1], which showed activity against (KB) human nasopharyngeal carcinoma cells (IC50 0.04 micrograms/ml) and inhibited tubulin assembly into microtubules (IC50 12 microM). Two other known flavonols, digicitrin [2] and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone [5], were also isolated together with three new ones, 3-O-demethyldigicitrin [3], 3,5,3'-trihydroxy-6,7,8,4'-tetramethoxyflavone [4], and 3,5-dihydroxy-6,7,8,3',4'-pentamethoxyflavone [6]. All of these flavonols showed cytotoxic activity against KB cells.
Zukünftige kommerzielle Nutzung von Methanhydratvorkommen im Meeresboden (2011)

Commercial utilization of methane hydrate deposits in the seabed: The vast amount of natural gas bound in methane hydrates is considered as future energy resource by a growing number of states and companies in South-East Asia and North America. Successful field production tests showed that gas hydrates can be dissociated in the sub-surface by heat addition and pressure reduction while the released gas is produced via conventional drill wells. Laboratory studies demonstrate that CO2 from coal power plants can be applied to liberate methane from the hydrate structure and produce natural gas while the injected CO2 is safely stored as hydrate in the sub-surface. The commercial exploitation of sub-seabed gas hydrates may start in the next decade pending on the success of field production tests off Japan scheduled for 2012 and 2014. Specific environmental risks are associated with the future utilization of gas hydrates. These include the extinction of special benthic ecosystems relying on methane from hydrates as energy source, the triggering of slope failure, and leakage of greenhouse gases into the marine environment. Suitable measures have to be taken to avoid these risks. An appropriate legal framework should be established at the international level to meet the specific challenges and risks associated with the commercial use of gas hydrates in the marine environment.
Räumliches Interferenzmanagement in OFDM-basierten zellularen Systemen (2013)

Der stetig steigende Kapazitatsbedarf zellularer Systeme erfordert eine Mehrfachnutzung des verfugbaren Spektrums an benachbarten Basisstationen. Die hierdurch entstehende Interferenz limitiert die erzielbaren Datenraten. In dieser Arbeit untersuchen wir Konzepte zur raumlichen Interferenzunterdruckung am Empfanger und zur Nutzung von Mehrnutzerdiversitat auf der Basis von Limited-Feedback Precoding. Im zweiten Schritt entwickeln wir Systemkonzepte zur Koordination von benachbarten Basisstationen, die auf voller Kanalkenntnis beruhen.
SAT-based synthesis of clock gating functions using 3-valued abstraction (2009)

Clock gating is a power reduction technique for digital circuits that works by eliminating unnecessary switching of parts of the clock network, a power-hungry component in hardware designs. An effective approach to clock gating synthesis is based on a functional analysis of the design using BDDs. Algorithms of this type attempt to build a BDD for a clock gating circuit and then reduce its size with an approximation. If the BDD of a particular latch grows too large the attempt to gate that latch is aborted. We replace BDDs with a SAT-based technique combined with 3-valued abstraction. Our technique generates the approximation directly from the circuit, and thus avoids the explosion. Furthermore, our technique is incremental in the sense that it produces a partial result (a weaker approximation) if time or memory limits are exceeded. Our experimentation shows that more than 70% of latches that could not be gated using the BDD-based approach were gated by the SAT-based method.
Self‐Assembly of a Double Calix[6]arene Pseudorotaxane in Oriented Channels (2007)

A synthetic study to disclose the more appropriate manner by which two calix[6]arene units could be connected for the construction of an extended tubular structure was undertaken. As a result, a head-to-tail double calix[6]arene having the structure of an oriented nanotube that is about 2.6 nm long and 1.6 nm wide was prepared and characterized. This molecule is able to act as a wheel-type host and forms a supramolecular complex with an axle-type molecule, derived from 4,4'-bipyridinium (viologen), through very efficient self-assembly in solution. The properties of such a pseudorotaxane-type complex, which is stabilized by a combination of noncovalent interactions, were investigated in solution by UV/Vis absorption spectroscopy and voltammetric methods. These observations provide a clue about the location of the bipyridinium unit along the nanotube. In the solid state, the complex undergoes a further stage of self-assembly, thereby initiating extended oriented tubular structures. Crystallographic studies revealed that the positioning of the viologen dication in this asymmetric wheel is addressed by a complicated pattern of cooperative noncovalent intermolecular interactions that involve only one half of the host, whereas the remaining (more polar) half of the host is exploited to create long-range structural order that leads to a "secondary" structure of extended supramolecular channels that, in turn, self-assemble in the lattice, thus giving rise to a "tertiary" structure of parallel sandwiches of nanotubes.
Notch-1 activates ErbB-2 through a PEA3-dependent mechansim. (2009)

Abstract Abstract #6015 Over-expression or gene amplification of ErbB-2 occurs in 25% of breast cancer which is associated with malignancy, poor overall survival, and resistance to some anti-hormonal therapies. Although trastuzumab has had a tremondous impact on survival, resistance results within the first year of treatment in 15% of cases and remains a major problem in the metastatic setting. We have recently published (Osipo et al., 2008. Oncogene) that the expression and activity of Notch-1, a potent breast oncogene and cell fate determinant is increased in ErbB-2 positive breast cancer cells in response to trastuzumab. Furthermore, we have shown that Notch-1 might contribute to trastuzumab resistance. In the current study, we asked whether Notch-1 could activate ErbB-2. Results demonstrated that a Notch inhibitor, γ-secretase inhibitor (GSI) or a Notch-1 siRNA decreased tyrosine phosphorylated and total ErbB-2 expression in SKBR3, MCF-7, and MDA-MB-231 cells. Furthermore, overexpression of constitutively active Notch-1 increased tyrosine phosphorylated ErbB-2 and reversed the inhibition by a GSI. ErbB-2 promoter activity using a luciferase reporter construct was decreased by Notch-1 siRNA only when the PEA3 Ets binding site was mutated. These results suggest that Notch-1 is an activator of ErbB-2 in breast cancer cells that express low or inactive PEA3. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6015.
ChemInform Abstract: Studies of Australian Ascidians. Part 6. Virenamides D and E, Linear Peptides from the Colonial Didemnid Ascidian Diplosoma virens (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tensile Characteristics of Connecting Portions of PaperboardSubjected to Indentation of Nicked Center Bevel Blade (2008)

The design assignment of connecting portions on a paperboard is important in order to stabilize the transport of the paperboard during die cutting. A mechanical estimation of various deformations of connecting portions is desired to predict an allowable assignment of connecting portions. The main purpose of this study is to reveal the elongation properties of the connecting portion of a paperboard with respect to several primary parameters such as nick width and crushed blade tip thickness. The result shows that there is a lower bound width of the connecting portion; the tensile strength of the connecting portion strongly depends on the cutting direction and grain (machine) direction of the paperboard. It is also clarified that the presence of string like dust affects the tensile strength of the connecting portion and that increasing blade tip thickness reduces the tensile strength of the connecting portion.
Controls on topographic dependence and temporal instability in catchment‐scale soil moisture patterns (2013)

Key Points Type of topographic dependence mainly depends on soil &amp; vegetation properties Temporal instability increases if lateral flow &amp; radiative ET are balanced Soil &amp; vegetation properties mainly determine if the dominant process changes
Comparative study of two sites of colonic conduit placement in the treatment of constipation due to rectal evacuatory disorders (1999)

The transverse colonic conduit offers better relief from the symptoms of constipation due to rectal evacuatory dysfunction than the sigmoid conduit.
Research on Expert Search at Enterprise Track of TREC 2005. (2005)

We (MSRA team) participated in the Expert Search task at the Enterprise Track of TREC 2005. This document reports our experimental results on expert search.
Direct Observation of Oxidative Cyclization of η2-Alkene and η2-Aldehyde on Ni(0) Center. Significant Acceleration by Addition of Me3SiOTf (2004)

Direct oxidative cyclization of (eta2:eta2-CH2=CHCH2C6H4CHO)Ni(PR3) to form the nickelacycle and drastic acceleration of the cyclization by the addition of Me3SiOTf were observed. (eta2-PhCHO)Ni(PCy3)2 also reacted with Me3SiOTf to give (eta1:eta1-Me3SiOCH(Ph))Ni(PCy3)OTf.
Extremely Broadband Slot Spiral Antenna with Shallow Reflecting Cavities (2000)

Previously, the broadband spiral class of antennas primarily consisted of the wire (or "printed")spiral and spirals with approximately complementary geometry. While both are very broadband radiators, they are still somewhat band-limited due to their associated balun structures, and bulky as a result of their absorbing cavities. A new type of spiral antenna utilizing slot radiating elements is presented that eliminates these drawbacks, relying instead on several new approaches to guarantee its frequency-independent operation over extremely broad bandwidths. The design and integration of a planar infinite balun/feed structure and very shallow reflecting cavity is presented and discussed, as is a new termination technique. Gain, axial ratio, and pattern measurements for both a 6" (15.24 cm)diameter spiral, with flow = 750 M Hz and 6.25:1 bandwidth, and an 18" (45.72lcm) diameter spiral, with flow = 250 M Hz and 15:1 bandwidth, are also given and reviewed.
New organometallic polymers containing tungsten carbene complexes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew organometallic polymers containing tungsten carbene complexesDavid W. Macomber, Mu Huang Hung, Mong Liang, Akhilkumar G. Verma, and Puttannachetty MadhukarCite this: Macromolecules 1988, 21, 4, 1187–1189Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/ma00182a061https://doi.org/10.1021/ma00182a061research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular engineering of organic semiconductors: design of self-assembly properties in conjugated thiophene oligomers (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular engineering of organic semiconductors: design of self-assembly properties in conjugated thiophene oligomersFrancis Garnier, Abderrahim Yassar, Ryad Hajlaoui, Gilles Horowitz, Francoise Deloffre, Bernard Servet, Simone Ries, and Patrick AlnotCite this: J. Am. Chem. Soc. 1993, 115, 19, 8716–8721Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ja00072a026https://doi.org/10.1021/ja00072a026research-articleACS PublicationsRequest reuse permissionsArticle Views4155Altmetric-Citations696LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neodymium-YAG laser iridotomy in angle closure glaucoma: preliminary study. (1987)

A prospective short-term preliminary clinical study to evaluate the efficacy and immediate complications of Q-switched Nd-YAG laser iridotomy in the treatment of acute and chronic angle closure glaucoma is described. The follow-up period ranged from four to 10 months. Of 40 eyes treated 36 (90%) required a single lasing session for patency (19, one application; 17, two applications), and four eyes (10%) required two sessions. Closure of the iridotomy site following Nd-YAG lasing due to pigment epithelium proliferation occurred in 10% of eyes, an incidence remarkably lower than that of argon laser iridotomy. Transitory closure or diminution of a prior patent iridotomy during the first hour after lasing was observed in 6.7% of eyes. Patency was again noted up to three weeks later and remained unchanged. Immediate postoperative complications included a marked increase in ocular pressure (42% of eyes), minimal transitory bleeding, and transitory localised corneal oedema at the lasing site. Persistent iridocorneal adhesion at the lasing site was noted in three eyes, and localised lenticular opacities, of non-progressive type, were observed in one eye.
Electrostatic Unfolding and Interactions of Albumin Driven by pH Changes: A Molecular Dynamics Study (2014)

A better understanding of protein aggregation is bound to translate into critical advances in several areas, including the treatment of misfolded protein disorders and the development of self-assembling biomaterials for novel commercial applications. Because of its ubiquity and clinical potential, albumin is one of the best-characterized models in protein aggregation research; but its properties in different conditions are not completely understood. Here, we carried out all-atom molecular dynamics simulations of albumin to understand how electrostatics can affect the conformation of a single albumin molecule just prior to self-assembly. We then analyzed the tertiary structure and solvent accessible surface area of albumin after electrostatically triggered partial denaturation. The data obtained from these single protein simulations allowed us to investigate the effect of electrostatic interactions between two proteins. The results of these simulations suggested that hydrophobic attractions and counterion binding may be strong enough to effectively overcome the electrostatic repulsions between the highly charged monomers. This work contributes to our general understanding of protein aggregation mechanisms, the importance of explicit consideration of free ions in protein solutions, provides critical new insights about the equilibrium conformation of albumin in its partially denatured state at low pH, and may spur significant progress in our efforts to develop biocompatible protein hydrogels driven by electrostatic partial denaturation.
Validation of Control Software Specification Using Design Interests Extraction and Model Checking (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Automotive control systems such as powertrain control interact with the open physical environment, and from this nature, expensive prototyping is indispensable to capture a deep understanding of the system requirements and to develop the corresponding control software. Model-based development (MBD) has been promoted to improve productivity by virtual prototyping. Even with MBD, systematic validation of the software specification remains as a major challenge and it still depends heavily on individual engineers' skill and knowledge. Though the introduction of graphical software modeling improved the situation, it requires much time to identify the primal functions, so-called “design interests”, from a large complex model where irrelevant components are mixed with, and to validate it properly. In addition, since software models have to coexist with legacy assets during the transition to MBD, the difficulty mentioned above should be overcome in terms of not only models, but also legacy C codes. As a remedy to this problem, we propose an approach based on design interests extraction from software model and/or legacy code. Design interests are mechanically extracted in the form of functional models and model checking is applied to exercise them. Currently, with our first tool implementation, a kind of dataflow graph is extracted from C codes as a functional model, and model checking is applied to prove specified properties on the dataflow graph and to generate execution traces which stimulate the specific parts of the design in a pinpoint manner. Such conditions are derived from the functional model.&lt;/div&gt;&lt;/div&gt;
Dispersion enhancement and damping by buoyancy driven flows in 2D networks of capillaries (2008)

The influence of a small relative density difference on the displacement of two miscible liquids is studied experimentally in transparent 2D networks of micro channels. Both stable displacements in which the denser fluid enters at the bottom of the cell and displaces the lighter one and unstable displacements in which the lighter fluid is injected at the bottom and displaces the denser one are realized. Except at the lowest mean flow velocity U, the average $C(x,t)$ of the relative concentration satisfies a convection-dispersion equation. The dispersion coefficient is studied as function of the relative magnitude of fluid velocity and of the velocity of buoyancy driven fluid motion. A model is suggested and its applicability to previous results obtained in 3D media is discussed.
The Mechanism of Action of Adenine in Red Cell Preservation* (1965)

effect of supplementing the ACD preservative with adenine alone from the beginning of storage and showed that small amounts of adenine, without nucleoside, preserve satisfactory viability of stored erythrocytes for at least 5 weeks.Adenine