gebhart/patrepeval huggingface dataset:
A methodology and architecture for interactive knowledge-based diagnostic problem solving in VLSI manufacturing (1993)

This dissertation describes an architecture for multimedia diagnostic knowledge-based systems, and a methodology for their development. The knowledge engineering methodology and the knowledge representation architecture introduced here are suited for the class of diagnostic problems whose analysis and resolution can be captured by condition-action trees and case libraries. The primary target applications include tool maintenance and troubleshooting, process control and diagnosis, and decision support. The proposed methodology improves knowledge capture and technology transfer by providing the necessary tools and techniques to domain experts.
Expert knowledge is represented as a hierarchy of condition-action trees (a generalization of decision trees) rather than by rules, decision tables, or complex models. This improves system performance, reduces system maintenance, enables incremental expansion, provides access to intermediate states and thus reduces search, and finally, it provides a representation consistent with the mental model of experts. The knowledge representation architecture involves three hierarchical levels of knowledge: the abstract behavioral level, representing general information about the domain of diagnosis; the structural level, capturing knowledge about specific tools, tasks, and processes; and the lowest level consisting of diagnosis and recovery information for individual problems.
Reasoning is also hierarchical, and can be described as a data-driven, look-ahead, breadth-first process. Inferencing is based on a hierarchical knowledge processing algorithm where nodes in the knowledge base are ranked following an entropy-based measure of useful information. Nodes can invoke hypermedia and multimedia service modules, which makes documentation available on-line in a focused manner. This interactive knowledge processing closely fits the everyday work environment, which improves the acceptance of diagnostic systems and their integration into the workplace.
The knowledge engineering methodology provides a set of guidelines to capture completely and accurately the knowledge hierarchy, reasoning strategy, and heuristics involved in the diagnostic process. These guidelines are based on supervised knowledge acquisition principles. They provide consistency, serve as checklists during the development process, and improve and encourage the expert's involvement. The proposed methodology also includes a strategy for technology transfer through top-down training and bottom-up development by domain experts.
Construction of the Superconducting ECR Ion Source Venus (2001)

A new, very high magnetic field superconducting ECR ion source, VENUS, is under development at the LBNL 88-Inch Cyclotron. It will boost the maximum energies and intensities for heavy ions from the cyclotron particularly for ions with mass greater than 60. It will also serve as R&D ion source for the proposed Rare Isotope Accelerator (RIA) project in the US, which requires up to 10 pµA of U30+. The superconducting magnet structure consists of three solenoids and six racetrack coils with iron poles forming the sextupole. The coils are designed to generate a 4 T axial mirror field at injection and 3 T at extraction and a radial sextupole field of 2.4 T at the plasma chamber wall. Test results of the magnet coils, which exceeded design requirements with minimum training, are presented. The magnet assembly with its cryostat will be enclosed by an iron shield and therefore must be designed to withstand any possible forces between coils and iron, which can be as high as 3.4 · 105 N (35,000 kgf). The low energy beam transport line (LEBT) and mass analyzing system of the ion source is designed to transport a proton- equivalent current of 25 mA at 20 kV extraction voltage. The design of the ion source and LEBT will be discussed.
Diagnose P2PSIP Overlay Network (2008)

This document describes a simple and efficient mechanism that can be
used to detect and localize failures in P2PSIP overlay network. This
document mainly consists of two parts: information carried in a P2PSIP
Peer Echo request message and Echo response message for the
purpose of fault detection and localization, and mechanisms for
processing those messages.
Parametric Resonance of Optically Trapped Aerosols (2007)

The Brownian dynamics of an optically trapped water droplet are investigated across the transition from over- to underdamped oscillations. The spectrum of position fluctuations evolves from a Lorentzian shape typical of overdamped systems (beads in liquid solvents) to a damped harmonic oscillator spectrum showing a resonance peak. In this later underdamped regime, we excite parametric resonance by periodically modulating the trapping power at twice the resonant frequency. The power spectra of position fluctuations are in excellent agreement with the obtained analytical solutions of a parametrically modulated Langevin equation.
Hospitalization of Jewish and Bedouin infants in Southern Israel for bronchiolitis caused by respiratory syncytial virus (1993)

We conducted a prospective study to determine the clinical picture and impact of respiratory syncytial virus (RSV) on hospitalization for acute bronchiolitis of pediatric patients less than 2 years of age belonging to two different ethnic groups in Southern Israel: Jews and Bedouins. All patients younger than 2 years of age hospitalized for bronchiolitis during a typical RSV season were enrolled. During the study period 120 patients with bronchiolitis were hospitalized, and 83 (69%) were RSV-positive. Their age ranged from 20 days to 9 months. Fifty-five percent of all patients with RSV bronchiolitis were < or = 3 months old and 92% were < or = 6 months old. Patients with RSV bronchiolitis represented 18% of all hospitalized infants < or = 9 months old and 35% of all hospitalizations for respiratory problems of infants < or = 9 months old. The yearly incidence of hospitalization for RSV bronchiolitis was 5.4/1000 live births for Jews and 18/1000 live births for Bedouins. The total number of hospitalization days calculated for 1000 births was 32.1 for the Jews and 86.7 for the Bedouins. RSV has a serious impact on infant morbidity in Southern Israel.
질소고정균(Rhizobium)과 인산가용화균(Bacillus megaterium)의 동시배양을 위한 배양조건 탐색 (2005)

다양한 기능을 보유하고있는 농업용 유용미생물을 경제적으로 대량생산하기 위하여는 동시에 다양한 미생물이 상호간에 길항관계를 갖지않고 잘자랄수있는 배지의 선택이 필수적으로 요망된다. 본실험은 질소고정균(Rhizobium)과 인산가용화균 (Bacillus megaterium)을 yeast extract mannitol변형배지를 포함한 다양한배지에서 함께 배양시 각각의 성장을 극대화할 수 있는 접종시차를 규명하고 각 조건에서 생산된 미생물의 효능유지기간을 비교하였다. 인산가용화균과 질소고정균을 동시배양시 최대 수율을 얻기위한 조건은 인산가용화균을 먼저접종란 후 48시간후에 질소고정균을 접종한 후 60시간 배양4하는것이었다. 이러한 조건으로 배양하였을 때 생산된 균의 효능유지기간은 각각의 균을 단독배양한것과 비교하여 차이가 나타나지 않았다 또한. 이러한 조건에서 생산된 미싱물의 개체수는 담체에 고정시킨후에도 60일가지 변화없이 유지되었다.
Preparation of t-Butyl Esters of Free Amino Acids1 (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of t-Butyl Esters of Free Amino Acids1Roger RoeskeCite this: J. Org. Chem. 1963, 28, 5, 1251–1253Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://doi.org/10.1021/jo01040a022Request reuse permissions Article Views3285Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Reconfigurable Convolutional Neural Network-Accelerated Coprocessor Based on RISC-V Instruction Set (2020)

As a typical artificial intelligence algorithm, the convolutional neural network (CNN) is widely used in the Internet of Things (IoT) system. In order to improve the computing ability of an IoT CPU, this paper designs a reconfigurable CNN-accelerated coprocessor based on the RISC-V instruction set. The interconnection structure of the acceleration chain designed by the predecessors is optimized, and the accelerator is connected to the RISC-V CPU core in the form of a coprocessor. The corresponding instruction of the coprocessor is designed and the instruction compiling environment is established. Through the inline assembly in the C language, the coprocessor instructions are called, coprocessor acceleration library functions are established, and common algorithms in the IoT system are implemented on the coprocessor. Finally, resource consumption evaluation and performance analysis of the coprocessor are completed on a Xilinx FPGA. The evaluation results show that the reconfigurable CNN-accelerated coprocessor only consumes 8534 LUTS, accounting for 47.6% of the total SoC system. The number of instruction cycles required to implement functions such as convolution and pooling based on the designed coprocessor instructions is better than using the standard instruction set, and the acceleration ratio of convolution is 6.27 times that of the standard instruction set.
Domains that confer intracellular sequestration of the Glut4 glucose transporter in Xenopus oocytes. (1993)

The Glut4 glucose transporter is poorly functional compared with other glucose transporter isoforms when expressed in Xenopus oocytes. To investigate the molecular basis for this poor functionality, we compared the biosynthesis and targeting of Glut1 and Glut4 in oocytes after microinjection of the corresponding mRNAs. Both Glut1 and Glut4 were present as lower molecular weight endoglycosidase H-sensitive and higher molecular weight endoglycosidase H-resistant. Subcellular fractionation indicated that Glut1 was targeted to the plasma membrane with a 6.6-fold greater efficiency than was Glut4. Confocal immunofluorescence microscopy confirmed the relative enrichment of Glut1 in the plasma membrane and the efficient intracellular sequestration of Glut4. As in mammalian cells, the endoglycosidase H-resistant form of Glut4 was concentrated in low-density intracellular vesicles, whereas Glut1 was distributed in intracellular vesicles of higher average density. The structural basis for the differential localization of Glut1 and Glut4 was investigated by determining the plasma membrane content of a series of chimeric Glut1/Glut4 molecules. These data indicated that two distinct regions of Glut4, encompassing residues 24-132 and the COOH-terminal cytoplasmic tail, confer intracellular sequestration on the chimeric transporter molecules. At least part of the sequestration effect of the more N-terminal domain was due to the incomplete maturation of chimeras containing this region, resulting in the accumulation of lower molecular weight endoglycosidase H-sensitive and endoglycosidase H-resistant forms, whereas the COOH-terminal cytoplasmic tail conferred sequestration of fully glycosylated chimeras in a low-density intracellular membrane compartment.
Liquid core light guide for laser angioplasty (1990)

It is shown that delivery of laser energy to intravascular targets through a flowing fluid-core laser angioplasty catheter offers new design possibilities and solutions to current practical problems facing laser angioplasty. Fluid-core catheters using iodinated radiographic contrast material as the core fluid can transmit high-peak-power visible laser pulses at high efficiencies while offering improved imaging of the target and distal vasculature. These catheters are simple to produce, are optically and mechanically stable, and are compatible with conventional angioplasty equipment and techniques. In canine coronary arteries in vivo, the catheters proved to be flexible, atraumatic, and able to deliver ablative high-peak-power laser pulses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Distributed Signal Processing for Out-of-System Interference Suppression in Cell-Free Massive MIMO (2023)

Cell-free massive multiple-input-multiple-output (CF-mMIMO) is a next-generation wireless access technology that offers superior coverage and spectral efficiency compared to conventional MIMO. With many future applications in unlicensed spectrum bands, networks will likely experience and may even be limited by out-of-system (OoS) interference. The OoS interference differs from the in-system interference from other serving users in that for OoS interference, the associated pilot signals are unknown or non-existent, which makes estimation of the OoS interferer channel difficult. In this paper, we propose a novel sequential algorithm for the suppression of OoS interference for uplink CF-mMIMO with a stripe (daisy-chain) topology. The proposed method has comparable performance to that of a fully centralized interference rejection combining algorithm but has substantially less fronthaul load requirements.
New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway (2017)

Deep genetic studies revealed that <i>phosphatase and tensin homolog</i> (<i>PTEN</i>) mutations or loss of expression are not early events in cancer development but characterize tumor progression and invasion. Loss of PTEN function causes a full activation of the prosurvival phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway, but the treatment with specific inhibitors of PI3K/AKT/mTOR did not produce the expected results. One of the alternative targets of PTEN is the focal adhesion kinase (FAK) kinase, mainly involved in the control of cancer cell spread. The connection between PTEN and FAK has been demonstrated in different tumor types, with reduced PTEN activity often correlated with increased expression and phosphorylation of FAK. FAK inhibition may thus represent a promising strategy, and some clinical trials are testing FAK inhibitors alone or combined with other agents in a number of solid tumors. However, only few preclinical and clinical data described the effects of the combination of PI3K/AKT/mTOR and FAK inhibitors. Increasing knowledge on the PTEN/FAK connection could confirm PTEN as a good prognostic marker for a combination strategy based on concomitant inhibition of PI3K/AKT and FAK signaling, in advanced metastatic malignancies with altered or reduced PTEN expression.
Superbase-Catalyzed anti-Markovnikov Alcohol Addition Reactions to Aryl Alkenes (2018)

The organic superbase P<sub>4</sub>- t-Bu catalyzes the direct anti-Markovnikov addition of alcohols to aryl alkenes to access valuable β-phenethyl ethers. A diverse substrate scope of aryl alkenes and alcohols is demonstrated, including heterocyclic systems and unprotected aminoalcohols. Mechanistic studies reveal that the reaction is under equilibrium control and extensive comparisons to common inorganic bases indicate that the broad reaction scope is uniquely enabled through the use of the organic superbase.
Molecular Characterization of an Ice Nucleation Protein Variant (InaQ) from Pseudomonas syringae and the Analysis of Its Transmembrane Transport Activity in Escherichia coli (2012)

The ice nucleation protein (INP) of Pseudomonas syringae has gained scientific interest not only because of its pathogenicity of foliar necroses but also for its wide range of potential applications, such as in snow making, frozen food preparation, and surface-display system development. However, studies on the transport activity of INP remain lacking. In the present study, a newly identified INP-gene variant, inaQ, from a P. syringae MB03 strain was cloned. Its structural domains, signal sequences, and the hydrophilicity or hydrophobicity of each domain, were then characterized. The deduced amino acid sequence of InaQ shares similar protein domains with three P. syringae INPs, namely, InaK, InaZ, and InaV, which were identified as an N-terminal domain, a central repeating domain, and a C-terminal domain. The expression of the full-length InaQ and of various truncated variants was induced in Escherichia coli to analyze their transmembrane transport and surface-binding activities, while using the green fluorescence protein (GFP) as the fusion partner. With two transmembrane segments and a weak secretion signal, the N-terminal domain (InaQ-N) alone was found to be responsible for the transport process as well as for the binding to the outer membrane, whereas the C-terminal region was nonfunctional in protein transport. Increased membrane transport and surface-binding capacities were induced by a low isopropyl-β-D-thiogalactoside concentration (0.1 mmol/l) but not by culture temperatures (15 ºC to 37 ºC). Furthermore, by constructing the GFP-fused proteins with a single InaQ-N, as well as two and three tandemly aligned InaQ-N molecules, the transport and membrane-binding activities of these proteins were compared using Western blot analysis, immmunofluorescence microscopy, and assays of the GFP specific fluorescence intensity of subcellular fractions and flow cytometry, which showed that the increase of InaQ-N repeats resulted in a coordinated increase of the surface-immobilization efficiency. Therefore, the results of this study can serve as a molecular basis for improving the performance of INP-based cell surface-display systems.
Panel summary report (1987)

The objective of this report is to summarize the various modeling approaches that were used to simulate solute transport in a variably saturated emission. In particular, the technical strengths and weaknesses of each approach are discussed, and conclusions and recommendations for future studies are made. Five models are considered: (1) one-dimensional analytical and semianalytical solutions of the classical deterministic convection-dispersion equation (van Genuchten, Parker, and Kool, this report ); (2) one-dimensional simulation using a continuous-time Markov process (Knighton and Wagenet, this report); (3) one-dimensional simulation using the time domain method and the frequency domain method (Duffy and Al-Hassan, this report); (4) one-dimensional numerical approach that combines a solution of the classical deterministic convection-dispersion equation with a chemical equilibrium speciation model (Cederberg, this report); and (5) three-dimensional numerical solution of the classical deterministic convection-dispersion equation (Huyakorn, Jones, Parker, Wadsworth, and White, this report). As part of the discussion, the input data and modeling results are summarized. The models were used in a data analysis mode, as opposed to a predictive mode. Thus, the following discussion will concentrate on the data analysis aspects of model use. Also, all the approaches were similar in that they were based on a convection-dispersion model ofmore » solute transport. Each discussion addresses the modeling approaches in the order listed above.« less
Synthesis of an activated phosphonated bifunctional chelate with potential for PET imaging and radiotherapy (2012)

The synthesis of a phosphonated acyclic bifunctional chelate L* for the labeling of biomaterial is described. L* is based on a pyridine backbone, functionalized in ortho positions by aminomethyl-bis-methylphosphonic acids, and, in the para position, by a side chain containing a reactive NHS carbamate function. The stability of L* in aqueous solutions at different pH values was studied by mass spectrometry, showing the activated function to be sensitive to hydrolysis above neutral pH. The reactivity of L* towards amine functions was tested using ethylamine under different conditions of pH and concentrations, and by the labeling of two reference peptides containing both an N-terminal amino function and a ε-amino group of a lysine residue in the backbone, and a supplementary thiol group of a cysteine residue for one of these two peptides. The results showed the coupling to be efficient at pH 8.0, with a total selectivity for the terminal amine function with respect to lysine and cysteine. The labeling was further performed on B28-13, a mouse monoclonal antibody specifically recognizing tenascin-C protein in human cancer. The labeled antibody was characterized by means of mass spectrometry and spectrofluorimetry, unraveling a labeling ratio of one chelate per antibody. Finally, the affinity of the labeled antibody towards its target was controlled by immunofluorescence staining experiments on human colon cancer biopsies, confirming the affinity of the labeled peptide for tenascin-C.
Fracture toughness characterization of nanoreinforced carbon-fiber composite materials for damage mitigation (2011)

Continuous polyacrylonitrile (PAN) nanofibers fabricated via the electrospinning process and commercially available silica nanoparticles were investigated and compared for their impact mitigating effects when incorporated into composite materials. The nanofibers were introduced at ply interfaces using two different approaches while the nanoparticles were mixed into the matrix material. Behavior was experimentally characterized by determining the fracture toughness of flat carbon-fiber composite coupons using the double cantilever beam (DCB) test according to ASTM D5528. The nanofibers were introduced to the composite coupons by directly electrospinning the fibers onto the ply surfaces or transferring the fibers from an interim substrate, or "nanomat", while the nanosilica particles were mixed into the resin system during vacuum bagging hand layup. Testing facilitated the calculation of Mode I strain energy release rates. Preliminary results show that when compared to a baseline coupon without nanoreinforcement, there is a 54.5%, 43.1%, and 26.9% reduction in Gavg for the nanomat, nanosilica, and directly deposited nanomaterial coupons, respectively. Directly deposited nanofibers outperformed the nanosilica reinforcement by 16.2% and the nanomat approach by 27.6%. Basic materials (carbon-fiber ply material and matrix system) and incomplete composite consolidation were cited as contributors to poor test coupon quality and detrimental to Mode I performance.
A synthetic ion channel with anisotropic ligand response (2020)

Biological membranes play pivotal roles in the cellular activities. Transmembrane proteins are the central molecules that conduct membrane-mediated biochemical functions such as signal transduction and substance transportation. Not only the molecular functions but also the supramolecular properties of the transmembrane proteins such as self-assembly, delocalization, orientation and signal response are essential for controlling cellular activities. Here we report anisotropic ligand responses of a synthetic multipass transmembrane ion channel. An unsymmetrical molecular structure allows for oriented insertion of the synthetic amphiphile to a bilayer by addition to a pre-formed membrane. Complexation with a ligand prompts ion transportation by forming a supramolecular channel, and removal of the ligand deactivates the transportation function. Biomimetic regulation of the synthetic channel by agonistic and antagonistic ligands is also demonstrated not only in an artificial membrane but also in a biological membrane of a living cell.