gebhart/patrepeval huggingface dataset:
Metagenomic Analysis of Ammonia-Oxidizing Archaea Affiliated with the Soil Group (2012)

Ammonia-oxidizing archaea (AOA) have recently been recognized as a significant compo- nent of many microbial communities and represent one of the most abundant prokaryotic groups in the biosphere. H owever, only few AOA have been successfully cultivated so far and information on the physiology and genomic content remains scarce. We have per- formed a metagenomic analysis to extend the knowledge of the AOA affiliated with group I.1b that is widespread in terrestrial habitats and of which no genome sequences has been described yet. A fosmid library was generated from samples of a radioactive ther- mal cave (46 ̊C) in the Austrian Central Alps in which AOA had been found as a major part of the microbial community. Out of 16 fosmids that possessed either an amo Aor 16S rRNA gene affiliating with AOA, 5 were fully sequenced, 4 of which grouped with the soil/I.1b ( Nitrososphaera -) lineage, and 1 with marine/I.1a ( Nitrosopumilus -) lineage. Phylogenetic analyses of amo BC and an associated conserved gene were congruent with earlier analyses based on amo A and 16S rRNA genes and supported the separation of the soil and marine group. Several putative genes that did not have homologs in currently available marine Thaumarchaeota genomes indicated that AOA of the soil group contain specific genes that are distinct from their marine relatives. Potential cis -regulatory elements around conserved promoter motifs found upstream of the amo genes in sequenced (meta-) genomes differed in marine and soil group AOA. On one fosmid, a group of genes including amo A and amo B were flanked by identical transposable insertion sequences, indicating that amo AB could potentially be co-mobilized in the form of a composite transposon. This might be one of the mechanisms that caused the greater variation in gene order compared to genomes in the marine counterparts. Our findings highlight the genetic diversity within the two major and widespread lineages of Thaumarchaeota.
The pro to toxin LYPD6B modulates heteromeric a3β4‐containing nicotinic acetylcholine receptors, but not α7 homomers (2015)

Prototoxins are a diverse family of membrane-tethered molecules expressed in the nervous system that modulate nicotinic cholinergic signaling, but their functions and specificity have yet to be completely explored. We tested the selectivity and efficacy of leukocyte antigen, PLAUR (plasminogen activator, urokinase receptor) domain-containing (LYPD)-6B on α3β4-, α3α5β4-, and α7-containing nicotinic acetylcholine receptors (nAChRs). To constrain stoichiometry, fusion proteins encoding concatemers of human α3, β4, and α5 (D and N variants) subunits were expressed in Xenopus laevis oocytes and tested with or without LYPD6B. We used the 2-electrode voltage-clamp method to quantify responses to acetylcholine (ACh): agonist sensitivity (EC50), maximal agonist-induced current (Imax), and time constant (τ) of desensitization. For β4-α3-α3-β4-α3 and β4-α3-β4-α3-α3, LYPD6B decreased EC50 from 631 to 79 μM, reduced Imax by at least 59%, and decreased τ. For β4-α3-α5D-β4-α3 and β4-α3-β4-α-α5D, LYPD6B decreased Imax by 63 and 32%, respectively. Thus, LYPD6B acted only on (α3)3(β4)2 and (α3)2(α5D)(β4)2 and did not affect the properties of (α3)2(β4)3, α7, or (α3)2(α5N)(β4)2 nAChRs. Therefore, LYPD6B acts as a mixed modulator that enhances the sensitivity of (α3)3(β4)2 nAChRs to ACh while reducing ACh-induced whole-cell currents. LYPD6B also negatively modulates α3β4 nAChRs that include the α5D common human variant, but not the N variant associated with nicotine dependence.
Conducting Redox Polymer Batteries – Challenges and possibilities (2017)

Apart from conventional metal based batteries, batteries consisting of naturally occurring organic materials can be envisioned, thus becoming fully sustainable and avoiding the negative environment ...
Molecular variants of HPV‐16 associated with cervical cancer in Indian population (2009)

Human papilloma virus is a causative factor in the etiology of cervical cancer with HPV16 being the most prevalent genotype associated with it. Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV 16 besides being of phylogenetic importance, are associated with risk of viral persistence and progression. The objective of this multicentric study was to identify HPV-16 E6, E7 and L1 variants prevalent in India and their possible biological effects. Squamous cell cervical cancer biopsies were collected from 6 centres in India and examined for the presence of HPV 16. Variants of HPV-16 were characterized by full length sequence analysis of L1, E6 and E7 genes in 412 samples. Similar distribution of the variants was seen from the different centres/regions, with the European variant E350G being the most prevalent (58%), followed by American Asian variant (11.4%). Fifty six changes were seen in E6 region, 31 being nonsynonymous. The most frequent being L83V (72.3%), Q14H (13.1%) and H78Y (12.1%). Twenty-nine alterations were seen in E7 region, with 12 being nonsynonymous. The most frequent being F57V (9%). L1 region showed 204 changes, of which 67 were nonsynonymous. The most frequent being 448insS (100%), and 465delD (100%), H228D (94%), T292A (85%). The identified variants some new and some already reported can disrupt pentamer formation, transcriptional regulation of the virus, L1 protein interface interaction, B and T cell epitopes, p53 degradation, and thus their distribution is important for development of HPV diagnostics, vaccine, and for therapeutic purpose.
Application of ADC techniques to characterize yield-limiting defects identified with the overlay of E-test/inspection data on short loop process testers (2003)

Automatic defect classification, using a combination of CRS IMPACT/sup TM/ ADC and 4300+ SEM ADC based approaches, can significantly improve data integrity and the rate of yield-limiting defect characterization. Implementation of ADC can enhance yield learning rates since it can improve the defect classification speed and improve the accuracy of the results. The data shows that both optical and SEM ADC approaches offer their own unique advantages. Optical ADC offers a faster significantly cheaper solution with less accuracy. Higher classification accuracy is obtained from the SEM based approach due to the higher magnifications coupled with the additional Z-information available only with tilted images. The ultimate approach would involve combination of the optical and SEM based approaches to take advantage of the strengths of each system.
A block of urovirulence genes encoding multiple fimbriae and hemolysin in Escherichia coli O4:K12:H- (1988)

Cosmid gene libraries were constructed from a uropathogenic isolate of Escherichia coli O4:K12:H- that secretes alpha-hemolysin and produces the F14, F12-rel, F1C, and F13 fimbrial antigens. A series of overlapping clones was generated, and individual cosmid clones were found to express various combinations of fimbriae and hemolysin, suggesting that the genes for these potential virulence factors are closely linked. By using Southern hybridization analysis and restriction endonuclease mapping, it was demonstrated that the cosmid clones carried a nested set of overlapping, cloned, genomic DNA fragments. A comparison of the phenotypic properties of individual cosmid clones and subclones allowed the order of the gene clusters encoding these factors to be deduced. The cloning also revealed the presence of a fifth fimbria that had P-adhesin specificity.
Remote control system using real-time MPEG-4 streaming technology for mobile robot (2003)

This paper presents a mobile robot system which not only achieves real-time compression and transmission of both MPEG-4 video and G.723 audio, but also controls the movement of the robot with a pan-tilt camera and robot arm via the Internet using WLAN.
Fabrication of Thermo-Responsive Molecular Layers from Self-Assembling Elastin-Like Oligopeptides Containing Cell-Binding Domain for Tissue Engineering (2015)

Novel thermo-responsive elastin-like oligopeptides containing cell-binding epitope (Arg-Gly-Asp-Ser sequence); arginine-glycine-aspartic acid-serine (RGDS)-elastin-like peptides (ELP) and RGDS-deg-ELP; were newly prepared as building blocks of self-assembled molecular layer for artificial extra cellular matrix. A detailed analysis of the conformation of the oligo(ELP)s in water and their self-assembling behavior onto hydrophobic surfaces were performed by using circular dichroism, Fourier transform infrared spectroscopy (FTIR), atomic force microscopy and water contact angle measurements. The experimental results revealed that both oligo(ELP)s self-assembled onto hydrophobic surfaces and formed molecular layers based on their thermo-responsive conformational change from hydrous random coil to dehydrated β-turn structure. Effective cell adhesion and spreading behaviors were observed on these self-assembled oligo(ELP) layers. In addition, attached cells were found to be recovered successfully as a cell-sheet by temperature-induced disassembly of oligo(ELP) layer. This achievement provides an important insight to construct novel oligopeptide-based nano-surfaces for the design of smart artificial extra-cellular matrix.
Extended Inferior Turbinate Flap for Endoscopic Reconstruction of Skull Base Defects (2014)

Objective When the use of the nasoseptal flap for endoscopic skull base reconstruction has been precluded, the posterior pedicle inferior turbinate flap is a viable option for small midclival defects. Limitations of the inferior turbinate flap include its small surface area and limited arc of rotation. We describe a novel extended inferior turbinate flap that expands the reconstructive applications of this flap. Design Cadaveric anatomical study. Participants Cadaveric specimens. Main Outcome Measures Flap size, arc of rotation, and reconstructive applications were assessed. Results The average width of the flap was 5.46 ± 0.58 cm (7.32 ± 0.59 cm with septal mucosa). The average length of the flap was 5.01 ± 0.58 cm (5.28 ± 0.37 cm with septal mucosa). The average surface area of the flap was ∼ 27.26 ± 3.65 cm(2) (40.53 ± 6.45 cm(2) with septal mucosa). The extended inferior turbinate flap was sufficient to cover clival defects extending between the paraclival internal carotid arteries. The use of the flap in 22 cadavers and 5 clinical patients is described. Conclusion The extended inferior turbinate flap presents an additional option for reconstruction of skull base defects when the nasoseptal flap is unavailable.
Anterior cervical plates: a historical perspective (2004)

The development of anterior cervical plates (ACPs) represents a rapidly changing aspect of spine surgery. This paper focuses on a historical overview of ACPs. The authors discuss the disadvantages of earlier generations of plates and demonstrate how current plates have been designed to overcome the presumed shortcomings of their predecessors. This historical review begins with the earliest plates--unrestricted backout plates--and moves on to newer plates--restricted backout plates and their different subcategories. Virtually all modern ACPs work equally well in cervical stabilization; however, there are differences in design that warrant future studies to understand the long-term performances of different plates.
Smooth navigation of road map in 3D scene (2004)

With the rapid development of ITS, information about ITS become larger and more complicated than before. How to represent it integrally and effectively is the task we will face. This paper proposes a multi-level displaying approach that can display the whole map and its region of interest at the same time without multi-window switch and over-lap. Besides, in order to view the road map in reality, the road map is super-imposed on terrain map. Two methods adopted in the system provide two possible ways to get good user interface.
Thermovision System Based on the IR CCD Matrix on PtSi with Shottky Barrier (2000)

Multipurpose thermovision system based upon the infrared CCD matrix with Shottky barrier has been build.Echnical parameters and software details (automatical contrasting, dynamic averaging) are considered.The second-generation thermovision system is based upon the infrared focal plane array.The focal plane array is monolithic platinum silicide Schottky-barrier IR charge coupled device image sensor.It is designed for infrared imaging applications in the 15 m wavelength range.The device has interline-transfer architecture and is oriented for backside illumination.Thin films of platinum silicide are used in manufacturing of Schottky-barrier detectors.The readout is carried out by vertical and horizontal CCD.Both CCDs have a buried channel, and are driven by four-phase clock pulses.The output preamplifier is a floating diffusion amplifier with a two-stage source follower.The high thermal and spatial resolution of device, low noise readout, and high uniformity produce a good quality thermal images in real time.
Endothelium-Dependent Contraction of Cerebral Arteries (1994)

Vascular tone is regulated by neuronal and humoral factors to maintain appropriate blood flow. SinceFurchgott and Zawadzki (1980) found the obligatory role of endothelial cells in the vasodilating action of acetylcholine (ACh) (endothelium-depen-dent relaxation, EDR), extensive studies on physiological activities of the endothelium in various vascular preparations have been investigated. Palmer et al. (1987) have identified chemically that the endothelium-derived relaxing factor (EDRF) is nitric oxide(NO). In peripheral arteries, EDRF has been considered to play an important role in regulation of vascular tone.KeywordsArachidonic AcidCerebral ArteryCerebral VasospasmCyclooxygenase InhibitorArachidonic Acid MetaboliteThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
A FLEXIBLE LASER SYSTEM PROVIDED WITH A LASER BEAM COMPOSITION UNIT FOR INDUSTRIAL APPLICATION (1984)

A study is presented of a flexible manufacturing system provided with several laser sources for industrial applications. In the configuration described the system is able to deliver a total output laser power on the workpiece of up to 6.5 kW carried by one, two or three laser beams, each of which can be addressed at any moment to any among five workstations. Cutting, welding, hardening, alloying and cladding can be performed on workpieces of different materials, dimensions and geometries in each workstation. Because of its intrinsic flexibility, this system is well suited for integrating in a more general flexible manufacturing complex.
Lean Miller Cycle System Development for Light-Duty Vehicles (Final Report) (2019)

This report summarizes activities conducted in support of the project “Lean Miller Cycle System Development for Light-Duty Vehicles” under Cooperative Agreement Number DE-EE0006853. In order to accomplish the government objective of achieving breakthrough thermal efficiencies while meeting U.S. EPA emission standards, this project focused on combining two enabling technologies in a gasoline engine: lean combustion and “Miller Cycle.” Lean combustion is thermodynamically more efficient than stoichiometric combustion but requires a more complex exhaust aftertreatment system compared to a traditional three-way catalyst system. The “Miller Cycle” concept increases expansion of combustion gases to extract additional work, reduces pumping losses, and increases efficiency. The objective of the project was to research, develop, and demonstrate the new Lean Miller Cycle (LMC) combustion concept to achieve a 35% improvement in fuel economy over a 2010 production baseline vehicle. The baseline vehicle chosen was a Chevrolet Impala equipped with a 3.5L V6 port-fuel injected naturally-aspirated engine, a four-speed automatic transmission with a peak-power and -torque of 157 kW and 290 N-m respectively. The enabling technologies were developed and demonstrated on a single cylinder engine and then integrated into a multicylinder engine and aftertreatment system. Along with achieving the efficiency targets, the downsized boosted LMC engine system was projected to achieve a peak-power and –torque of 172 kW at 354 Nm respectively exceeding the baseline engine performance. The multicylinder engine was optimized and calibrated over a set of steady-state operating points on an engine dynamometer. The target of the project was a 35% improvement in combined city/highway fuel economy at SULEV30 tailpipe emissions over the baseline vehicle. The project achieved a projected 42.4% from the vehicle drive cycle analysis assuming no penalty for management of the lean-aftertreatment system. This penalty was projected to fall within the fuel economy margin achieved and include control and calibration compromises for catalyst heating, NH3 formation for lean-NOx SCR and drive quality. A final vehicle demonstration was planned where emissions, drivability and performance were to be confirmed. Four decision gates were set up annually with deliverables to assess progress and determine whether status to deliverables warranted project continuation through the final vehicle demonstration. The project was closed in June 2019 at the end of budget period three after not passing the third decision gate due to projected system costs prohibiting economic feasibility in the light-duty vehicle industry landscape. However, the project’s efficiency targets were achieved by validation through steady-state dynamometer testing of the multicylinder engine.
Forecasting economic time series with the DyFor genetic program model (2008)

Genetic programming (GP) uses the Darwinian principle of survival of the fittest and sexual recombination to evolve computer programs that solve problems. Several studies have applied GP to forecasting with favourable results. However, these studies, like others, have assumed a static environment, making them unsuitable for many real-world time series which are generated by varying processes. This study investigates the development of a new ‘dynamic’ GP model that is specifically tailored for forecasting in nonstatic environments. This dynamic forecasting genetic program (DyFor GP) model incorporates methods to adapt to changing environments automatically as well as retain knowledge learned from previously encountered environments. The DyFor GP model is tested on real-world economic time series, namely the US Gross Domestic Product and Consumer Price Index Inflation. Results show that the DyFor GP model outperforms benchmark models from leading studies for both experiments. These findings affirm the DyFor GP's potential as an adaptive, nonlinear forecasting model.
Stable carbocations. CLV. Ethylenechloronium and methylchlorocarbenium ions (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStable carbocations. CLV. Ethylenechloronium and methylchlorocarbenium ionsGeorge A. Olah, David A. Beal, and Philip W. WestermanCite this: J. Am. Chem. Soc. 1973, 95, 10, 3387–3389Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://doi.org/10.1021/ja00791a055Request reuse permissionsArticle Views54Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (405 KB) Get e-Alertsclose Get e-Alerts
Impact of oral cyclophosphamide on health‐related quality of life in patients with active scleroderma lung disease: Results from the scleroderma lung study (2007)

One year of treatment with CYC leads to an improvement in HRQOL in patients with scleroderma lung disease.
Enhanced susceptibility of mice to combinations of delta 9-tetrahydrocannabinol and live or killed gram-negative bacteria (1977)

Combinations of delta 9-tetrahydrocannabinol (delta 9-THC) and bacterial endotoxin were shown to be hyperadditively toxic for mice. A variety of purified lipopolysaccharide (LPS) preparations elicted enhanced mortality in combination with delta 9-THC. Escherichia coli O26:B6 LPS (Boivin preparation) at an essentially nonlethal dose of 2.5 mg/kg reduced the dose of delta 9-THC required to kill 50% of the treated mice from ca. 350 to 150 mg/kg. Inbred BALB, DBA, and C3H/HeCr mice, noninbred ICR mice, and hybrid CDF1 and BDF1 mice were hyperreactive to combinations of delta 9-THC and LPS. Moreover, a variety of heat-killed intestinal and gram-negative bacteria, live E. coli, and complexes of lipid A with a variety of proteins substituted for LPS in the synergistic toxicity of LPS and delta 9-THC. Extracts of marijuana also elicited hyperreactivity to LPS. The hyperadditive lethality of combinations of delta 9-THC and LPS was markedly less in mice rendered refractory to LPS or delta 9-THC by repeated administration of LPS or delta 9-THC, respectively.
Nanostructure Engineering and Doping of Conjugated Carbon Nitride Semiconductors for Hydrogen Photosynthesis (2013)

Going flat out: Simultaneous modifications of the textural, surface, and electronic structures of a rigid conjugated carbon nitride polymer has been achieved using direct co-condensation of urea and Ph4BNa. This method gives boron-doped carbon nitride nanosheets (see picture) that optimize the capture of light, improve the charge-separation kinetics, and enhance the surface reactivity for hydrogen photosynthesis.