gebhart/patrepeval huggingface dataset:
Geolocation in the mobile web browser (2010)

Current mobile browser capabilities make it possible to quickly develop advanced mobile location based services without having to write device specific software, or build custom hardware. We here describe three web applications exploring using location within mobile browsers (TågAlong, NearMe and LocalURL). These explorations show clear potential for using geolocation in the web browser in order to reach a larger user base, with a greater variety of devices, thus allowing for UbiComp researchers to explore the effects of specific services and applications on a larger scale. We discuss the services, as well as the potential and challenges with using the user's location directly in the browser.
Changes in plasma lipids and uric acid with sodium loading and sodium depletion in patients with essential hypertension. (1988)

The short-term effects of manipulating dietary salt intake on plasma levels of cholesterol, lipoproteins and uric acid were studied in two groups of patient with essential hypertension. With dietary salt restriction in 8 patients (10 g to 2 g salt/day for five days), plasma total cholesterol, esterified cholesterol, beta-lipoprotein, low density lipoprotein and uric acid rose significantly. With salt repletion (2 g salt/day to 20 g/day for five days) in 17 patients, plasma total cholesterol, esterified cholesterol, beta-lipoprotein, low density lipoprotein and uric acid fell significantly. Total/HDL cholesterol ratio increased significantly with salt restriction and decreased significantly with repletion. However, very low density lipoprotein, HDL-cholesterol, triglyceride, phospholipid, chylomicron and non-esterified fatty acid were not influenced by the changes in salt intake. These results indicate that the severe restriction of dietary salt raises plasma cholesterol and uric acid levels in patients with essential hypertension in the short term.
Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β (2011)

During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. A similar mechanism operates in mitosis to generate a gradient of active spindle assembly factors around mitotic chromosomes. Importin-β and RanGTP have been implicated in additional cellular processes, but the precise roles of the Ran/importin-β pathway throughout the cell cycle remain poorly understood. We implemented a FRET-based, high-throughput small molecule screen for compounds that interfere with the interaction between RanGTP and importin-β and identified importazole, a 2,4-diaminoquinazoline. Importazole specifically blocks importin-β-mediated nuclear import both in Xenopus egg extracts and cultured cells, without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export. When added during mitosis, importazole impairs the release of an importin-β cargo FRET probe and causes both predicted and novel defects in spindle assembly. Together, these results indicate that importazole specifically inhibits the function of importin-β, likely by altering its interaction with RanGTP. Importazole is a valuable tool to evaluate the function of the importin-β/RanGTP pathway at specific stages during the cell cycle.
Facile synthesis of porous spherical La0.8Sr0.2Mn1−xCuxO3(0 ≤x≤ 0.4) and nanocubic La0.8Sr0.2MnO3with high catalytic activity for CO (2018)

A molten salt method has been used to prepare porous La<sub>0.8</sub>Sr<sub>0.2</sub>Mn<sub>1−x</sub>Cu<sub>x</sub>O<sub>3</sub>(0 ≤<italic>x</italic>≤ 0.4) (LSMC-<italic>X</italic>) microspheres and La<sub>0.8</sub>Sr<sub>0.2</sub>MnO<sub>3</sub>(LSM) nanocubes using spherical and cubic MnCO<sub>3</sub>as templates, respectively.
Swift phase-coherent P-Pdot solution for the 1E1547.0-5408 outburst (2008)

Swift XRT monitored 1E1547.0-5408 in the latest 5 days starting from about 90 seconds since the BAT trigger (Krimm et al. GCN 8311, 8312). During this period observations in the WT mode were carried out for a total exposure time of about 37ks. After having removed bursts and corrected the photon arrival times to the barycenter of the Solar System, the dataset was used to infer a phase-coherent timing solution including both a period and period derivative component.
Longitudinal study of the contractile and electrical properties of single human thenar motor units (1998)

Serial motor unit number estimates have shed important light on the extent and rates of motoneuron losses in aging and amyotrophic lateral sclerosis. However, the estimates alone provide few clues to the health and functional status of surviving motor units. A reliable means for assessing the functional status of the surviving motor units would therefore by a welcome addition to our present tools for studying motor units. Examining the physiological properties of samples of motor units drawn at intervals during the course of a motoneuronal disease suffers from the important limitation that the samples may not be representative of one another. The latter problem could be circumvented by serially studying the same motor units. This study describes a noninvasive technique capable of longitudinally tracking the contractile and electrical properties of specific single thenar motor units in healthy subjects, in some instances over several years. The technique proved to be reasonably reliable and provided information on a wide range of contractile and electrical properties of motor units. Such an approach could serve as a potentially powerful and sensitive means of studying the life histories of single motor units in aging, diseases of the motoneuron, and in the latter instances, the responses of the motoneurons to treatment.
Conserved codon adaptation in highly expressed genes is associated with higher regularity in mRNA secondary structures (2020)

ABSTRACT The redundancy of the genetic code allows for a regulatory layer to optimize protein synthesis by modulating translation and degradation of mRNAs. Patterns in synonymous codon usage in highly expressed genes have been studied in many species, but scarcely in conjunction with mRNA secondary structure. Here, we analyzed over 2,000 expression profiles covering a range of strains, treatments, and developmental stages of five model species ( Escherichia coli, Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorhabditis elegans , and Mus musculus ). By comparative analyses of genes constitutively expressed at high and low levels, we revealed a conserved shift in codon usage and predicted mRNA secondary structures. Highly abundant transcripts and proteins, as well as high protein per transcript ratios, were consistently associated with less variable and shorter stretches of weak mRNA secondary structures (loops). Genome-wide recoding showed that codons with the highest relative increase in highly expressed genes, often C-ending and not necessarily the most frequent, enhanced formation of uniform loop sizes. Our results point at a general selective force contributing to the optimal expression of abundant proteins as less variable secondary structures promote regular ribosome trafficking with less detrimental collisions, thereby leading to an increase in mRNA stability and a higher translation efficiency.
Irinotecan-based combinations for the adjuvant treatment of stage III colon cancer. (2000)

Irinotecan (Camptosar) is a topoisomerase I inhibitor with demonstrated antitumor activity against a wide variety of malignancies. Phase II studies have shown that this agent has significant single-agent activity against both chemotherapy-naive and fluorouracil (5-FU)-refractory colorectal cancer. Phase III studies now indicate that irinotecan/5-FU/leucovorin combinations have antitumor activity superior to standard 5-FU/leucovorin regimens alone. These irinotecan-based combinations are now entering clinical trials for the adjuvant treatment of resected stage III colon cancer. It is hypothesized that the superior antitumor activity of these irinotecan-based combinations seen in the metastatic setting will translate into improved survival and increased cure rates in these earlier-stage patients.
The Effect of Pedagogical Practices Employed by “Connecting Classrooms” Teachers’ on the Learning Outcomes of Elementary Level Students (2022)

Teachers’ training is a vital component of ensuring quality education. There are a number of organizations that work to promote teachers’ education. The British Council's Connecting Classrooms programme is a global initiative, in Punjab, this programme has been implemented for public sector schools in partnership with School Education Department since 2015. The present study was designed to investigate the effect of this program on teachers’ pedagogical practices and students’ learning. Researcher employed Causal Comparative design. It was delimited to the public sector’s schools of Lahore, Multan, and Rawalpindi. Population of the study was comprised on elementary portions of schools, their teachers, and students. Multistage sampling technique was used. The sample was consisted of 134 schools, 536 teachers, and 2680 students. During study, three instruments were used, a knowledge Questionnaire, an observation sheet, and PEC papers. The study concluded that teachers’ who got the chance to work on international ethos, their pedagogical practices and students’ performance were comparatively better.
ADAPTIVE NON-LINEAR NETWORK FILTER ESTIMATION ERROR FOR STEREO ECHO CANCELLATION IN HOME THEATRE 9.1 SURROUND SOUND SYSTEM (2018)

In this paper, an adaptive non-linear network filter (ANLNF) approach based on Radial Basis Function Neural Networks (RBFNNs) is proposed for the stereo echo cancellation that is a necessary process for reducing undesired signal owing that the audiences can receive the apparent sound signal. The Gaussian activation function is suitable in used to model the characteristic of room transfer function. The samples of the direct sound and the echo sound signal in home theatre are applied as the input for the adaptive non-linear network filter. Finally, the simulation results illustrate the predicted error between the actual sound and direct sound, the Echo Return Loss Enhancement (ERLE) and Mean Square Error (MSE) in order to guarantee the clarity sound signal. We observe that the proposed algorithm outperforms compared with the other methods as Adaptive Filter with Gain and Time-Shift, Wiener Adaptive Filter, Feedforward Network and Average Recursive Least Square, respectively.
Influence of Cu on the Mechanical Properties of an Al-4.4wt%Mg Alloy after ECAP (2006)

Two Aluminium alloys, type AA5182 and AA5182+1.2wt% Cu, have been studied. The second alloy in solution treated condition is 18% stronger than the first one. During ageing at 150°C or 200°C it shows a characteristic fast increase in yield strength during the first minutes of ageing, followed by a 'plateau'. Both materials have been deformed in an ECAP die (4 and 8 passes) at 200°C and the microstructure, hardness and mechanical properties in compression at room temperature have been investigated. Although in none of the two materials a true sub-micron grain size was obtained at 200°C, a fair combination of strength and strain hardening was observed. The AA5182+Cu alloy, when ECAP’ed after a solution treatment and quenching, shows an increase in strength of about 20% compared to the AA5182 reference alloy. A post-ECAP annealing at 200°C does not lead to a further increase in hardness or strength. An analysis of the substructure and the mechanical properties during ECAP led to the conclusion that the precipitates formed during ECAP at 200°C do not directly contribute to the higher strength of alloy AA5182+Cu, but they contribute indirectly by slowing down the recovery.
Disruption of Individual Members of Arabidopsis Syntaxin Gene Families Indicates Each Has Essential Functions (2001)

Anton A. Sanderfoot, Marsha Pilgrim, Luc Adam, Natasha V. Raikhel, Disruption of Individual Members of Arabidopsis Syntaxin Gene Families Indicates Each Has Essential Functions, The Plant Cell, Vol. 13, No. 3 (Mar., 2001), pp. 659-666
A Hardware Efficient LDPC Encoding Scheme for Exploiting Decoder Structure and Resources (2007)

Previously, there has been no report on implementation effort to integrate LDPC encoder and decoder into a single hardware. In this paper, we propose a simple yet low complex systematic LDPC encoding method for class of quasi-cyclic low-density parity-check (QC-LDPC) codes to let LDPC encoder acquire an interchangeable structure, exploited in the decoder. With the proposed encoding scheme, implementation of the proposed encoder becomes much more hardware efficient than having a separate hardware due to LDPC encoder and decoder resource sharing. Moreover, the overall computational complexity of the proposed encoding scheme is lower than the well-known Richardson's efficient encoding scheme (A.T.J. Richardson and R.L. Urbanke, 2001).
Near‐Infrared LED Photobiomodulation Attenuates Hypoglycemia‐Induced Cardiotoxicity in a Rodent Model of Diabetes Mellitus (2010)

Diabetes‐induced hyperglycemia disrupts mitochondrial energy metabolism and increases oxidative stress. 670 nm light‐emitting diode photobiomodulation (PBM) has been shown to protect mitochondria, attenuate oxidative damage and improve cell survival in experimental and clinical investigations. We tested the hypothesis that 670 nm photobiomodulation would attenuate hypoglycemia‐induced cardiotoxicity in a model of type I diabetes, the streptozotocin (STZ)‐treated rat. Wistar rats were randomly assigned into 3 treatment groups: Control (CON), STZ‐treated (STZ) [50 mg/kg, ip] and 670 nm NIR treated [5 min; 15 J/cm 2 ) STZ‐diabetic rats (NIR). After 98 days of diabetic hyperglycemia animals were euthanized. The heart was harvested, flash frozen and stored at −80 C until analyzed. STZ‐induced diabetes depleted total antioxidants, increased the ratio of oxidized to reduced glutathione, increased nitrotyrosine, decreased catalase, decreased thioredoxin reductase and increased caspase‐3 activity in heart tissue. NIR treatment prevented these cytotoxic actions of STZ. The results support our hypothesis that NIR photobiomodulation attenuates oxidative stress in diabetic cardiomyopathy and suggest that it has therapeutic potential as a cytoprotective strategy for the treatment of diabetes and other chronic degenerative diseases. (RGI [UWM]; BTA [State of Wisconsin]).
Recovery of Sulfur Dioxide from Water Gases (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRecovery of Sulfur Dioxide from Water GasesH. F. Johnstone, H. J. Read, and H. C. BlankmeyerCite this: Ind. Eng. Chem. 1938, 30, 1, 101–109Publication Date (Print):January 1, 1938Publication History Published online1 May 2002Published inissue 1 January 1938https://pubs.acs.org/doi/10.1021/ie50337a020https://doi.org/10.1021/ie50337a020research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The de novo phospholipid effect of insulin is associated with increases in diacylglycerol, but not inositol phosphates or cytosolic Ca2+ (1985)

We have previously reported that insulin increases the synthesis de novo of phosphatidic acid (PA), phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP), phosphatidylinositol 4,5-bisphosphate (PIP2) and diacylglycerol (DAG) in BC3H-1 myocytes and/or rat adipose tissue. Here we have further characterized these effects of insulin and examined whether there are concomitant changes in inositol phosphate generation and Ca2+ mobilization. We found that insulin provoked very rapid increases in PI content (20% within 15 s in myocytes) and, after a slight lag, PIP and PIP2 content in both BC3H-1 myocytes and rat fat pads (measured by increases in 32P or 3H content after prelabelling phospholipids to constant specific radioactivity by prior incubation with 32Pi or [3H]inositol). Insulin also increased 32Pi incorporation into these phospholipids when 32Pi was added either simultaneously with insulin or 1 h after insulin. Thus, the insulin-induced increase in phospholipid content appeared to be due to an increase in phospholipid synthesis, which was maintained for at least 2 h. Insulin increased DAG content in BC3H-1 myocytes and adipose tissue, but failed to increase the levels of inositol monophosphate (IP), inositol bisphosphate (IP2) or inositol trisphosphate (IP3). The failure to observe an increase in IP3 (a postulated 'second messenger' which mobilizes intracellular Ca2+) was paralleled by a failure to observe an insulin-induced increase in the cytosolic concentration of Ca2+ in BC3H-1 myocytes as measured by Quin 2 fluorescence. Like insulin, the phorbol diester 12-O-tetradecanoylphorbol 13-acetate (TPA) increased the transport of 2-deoxyglucose and aminoisobutyric acid in BC3H-1 myocytes. These effects of insulin and TPA appeared to be independent of extracellular Ca2+. We conclude that the phospholipid synthesis de novo effect of insulin is provoked very rapidly, and is attended by increases in DAG but not IP3 or Ca2+ mobilization. The insulin-induced increase in DAG does not appear to be a consequence of phospholipase C acting upon the expanded PI + PIP + PIP2 pool, but may be derived directly from PA. Our findings suggest the possibility that DAG (through protein kinase C activation) may function as an important intracellular 'messenger' for controlling metabolic processes during insulin action.
Waste Classification of Slag Generated in a Pilot-Scale Entrained-Flow Gasifier (2012)

Series of gasification tests have been completed in the pilot-scale entrained-flow slagging gasifier at CanmetENERGY using Canadian coals, oil-sand coke, and blends of these fuels to determine if the produced slags are nonhazardous in nature. Solid wastes generated during these tests were analyzed for their trace metals, crystallinity, and toxic constituent leaching tendency in an attempt to provide more insight into the possibility of disposal or by-product use of gasifier-produced solid waste. The gasification tests were performed at conditions representative of commercial gasifiers using a dry-fuel-feed configuration. The lower-volatility elements were found to partition between the slag and process-water solids (PWS) collected after gasification of the oil-sand coke. The less volatile group 1 elements tended to be enriched in both solid streams, whereas the slightly more volatile group 2 elements tended to exhibit higher enrichment in the PWS. Slag samples were found to be inert with regard to their leaching potential, and so these materials can be considered nonhazardous.
Assessment ofERBB2/HER2Status inHER2-Equivocal Breast Cancers by FISH and 2013/2014 ASCO-CAP Guidelines (2018)

The indiscriminate use of alternative control probes to calculate HER2 FISH ratios in HER2-equivocal breast cancers may lead to false-positive interpretations of HER2 status resulting from unrecognized heterozygous deletions in 1 or more of these alternative control genomic sites and incorrect HER2 ratio determinations.
The Hydrogen Program: The present understanding of cyclic venting tanks (1992)

On the high-level waste tanks on the Hanford Site, 23 tanks have been identified as having a potential to generate and release hydrogen gases in a episodic manner. Efforts were initiated in 1990 to ensure safe operation of the tanks, to conduct a characterization of the waste, and to develop approaches for mitigating the release of hydrogen containing gases. The focus of the efforts has been on Tank 241-SY-101 because it has been shown to be the most active tank for the cyclic release of gases. This tank vents gases about every 100 days, and the major components have been determined to be hydrogen (fuel), nitrous oxide (oxidizer) and nitrogen in about equal portions. In some cases, the venting has resulted in mixtures that are above the lower flammability limit. This paper will describe monitoring and characterization data obtained during the most recent gas release events and the results from the analysis of a full core sample taken from Tank 241-SY-101. Summary details of changes in temperature profiles for the tank and other instrument observations during release, gas composition, and volume data are reported. The paper will provide information on the results of synthetic waste studies aimed at defining themore » mechanisms of flammable gas generation, storage, and release. The new data obtained from characterization, monitoring, tank behavior modeling, and research studies on waste have provided sufficient understanding of the tank behavior that the Waste Tank Safety program is exploring remediation and mitigation alternatives. Finally, the presentation will summarize preliminary steps taken to define mitigation and remediation strategies for Tank 241-SY-101 and to close out the safety issue.« less