gebhart/patrepeval huggingface dataset:
CAMP: Computer-Aided Music Processing (1991)

In the field of electronic music today, computers of many different types and sizes are in use. The musician is often hindered, however, by a steep learning curve, rigid system architecture, and limited application fields of the available music software. This document presents the design of a music development system that provides the committed musician with a creative tool for conventional music composition and production and for the realization of unconventional ideas such as algorithmic music or sound processing. The CAMP-system (Nieberle et al. 1988) runs on personal computers linked by a network we have developed. A flexible, system-wide message-passing system for communication processes provides full network capability. Important system components, such as the output buffers and process table, are distributed. This architecture allows several musicians simultaneous utilization in a communicative, interactive way and increases the available computing power. More than one computer can control clusters of synthesizers simultaneously. The result is a distributed, real-time-oriented, interactive music development system that provides powerful tools easy to handle. The CAMP-system music software is written in the Forth programming language. The CAMP-Forth music language includes several modern concepts and software engineering tools for easy development of music such as objectoriented elements (Nieberle and Orberger 1989) that provide a more abstract and therefore easier way to code compositional ideas and complex algorithms. One application of these tools is the implementation of device-independent drivers and on-line editors for MIDI-instruments and special DSP-hardware developed by our group. The expansion of existing language elements for
Some Key Elements To A Successful Design Based Course (2020)

Design-based courses often afford instructors more latitude in teaching styles and curriculum (inductive teaching/learning), relative to the more traditional courses (deductive teaching/learning). With some effort and planning, design-based classes can be developed into a successful alternative learning environment. Three key principles, which have been found to enhance learning, are discussed. These principles include integrating lab and lecture topics, promoting student enthusiasm, and providing exposure to real-world engineering. The suggestions and techniques presented in this paper come from the authors' experiences associated with developing and teaching a design-based hydraulic structures course over the last six years at Utah State University.
The diffusion of germanium in silicon (1973)

The diffusion of germanium in single-crystal silicon has been measured using the radioactive tracer 71Ge and a thin sectioning technique. The activation energy of 4.7 eV determined from the data is analyzed by considering the expected contribution due to the wrong-sized impurity ions. It is concluded that the high activation energy observed is expected from analogy to silicon self-diffusion.
Advair Diskus® (Salmeterol Xinafoate) (2010)

This chapter contains sections titled: Advair Diskus® and the Asthma and COPD Markets Salmeterol Tail Bromides and Aldehydes by Williamson Ether Synthesis Salmeterol Tail Amines by Nucleophilic Displacement of a Bromide, Iodide, or Methanesulfonate Salmeterol Head Electrophiles Salmeterol Head Amines and Carbamates Salmeterol (1) from Tail Electrophiles and Head Nucleophiles Salmeterol (1) from Tail Nucleophiles and Head Electrophiles Alternative Strategies for Joining the Head and Tail Polymorphs and Particle Size The Best Process Available Today Manufacturing 4-phenyl-1-butanol Structures Searched References
Solid-Supported Solution-Phase Synthesis of 4-Amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones (2004)

Starting from Boc-o-aminomethylphenylalanine, a solution-phase parallel synthesis of 2,4-substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones is described. This heterocycle has two nitrogen functions, which are differentiated and can be selectively substituted. The sources of diversity are aldehydes for the R(1) position and carboxylic acids, sulfonyl chlorides, or isocyanates for the R(2) position. High-throughput synthesis and purification of this multistep synthetic sequence was accomplished using polymer-bound reagents and scavengers and liquid-liquid extraction protocols, and a small library of compounds was prepared. Polymer-bound cyanoborohydride was found to work well for the reductive amination. Scavenging of excess of amine was performed by polymer-bound benzaldehyde, and cyclization was performed in the presence of polymer-bound coupling reagent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). After Boc-deprotection, the second nitrogen can be acylated using carboxylic acids, sulfonylated or converted to a urea. The acylation is again performed by polymer-bound EDC. Excellent yields and purities were obtained.
The waiting game: laparoscopic repair of dual Morgagni and paraesophageal hernias in an elderly, infirm patient (2019)

Morgagni hernias are congenital diaphragmatic disruptions that occur when intra-abdominal organs herniate posterior to the sternum. It is very rare to concomitantly diagnose a paraesophageal hernia (PEH) in a patient with a Morgagni hernia. Here, we describe an elderly female patient presenting with severe chest pain subsequently diagnosed with a non-strangulated Morgagni hernia as well as PEH. She underwent successful robotic laparoscopic surgical repair of the hernias with resolution of her symptoms. This case demonstrates the need for early surgical intervention of Morgagni hernias to prevent sequelae, such as strangulation, and the rising benefits of laparoscopic repairs in adult patients.
Temporal Effects of Lactic Acid Bacteria Probiotic Culture on Salmonella in Neonatal Broilers (2007)

We evaluated the ability of a commercially available lactic acid bacteria-based probiotic culture (LAB) to reduce Salmonella Enteritidis or Salmonella Typhimurium in day-of-hatch broiler chicks. In these experiments, chicks were challenged with Salmonella Enteritidis or Salmonella Typhimurium and treated with LAB 1-h postchallenge. Following treatment, cecal tonsils and ceca were aseptically collected for Salmonella Enteritidis or Salmonella Typhimurium enrichment or Salmonella Enteritidis enumeration, respectively. In experiments 1 to 3, LAB significantly reduced the incidence of Salmonella Enteritidis (60 to 70% reduction) or Salmonella Typhimurium (89 to 95% reduction) recovered from the cecal tonsils of day-old broiler chicks 24 h following treatment as compared with controls (P < 0.05). Additionally, administration of LAB caused a >2.9 log(10) reduction of total cecal Salmonella Enteritidis recovered 24 h following treatment as compared with controls (P < 0.05). In experiments 4 to 7, upon sample enrichment LAB significantly reduced the recovery of Salmonella Enteritidis from the cecal tonsils at 24 h, but not 6 or 12 h posttreatment (P < 0.05). However, in experiments 6 and 7, when total cecal Salmonella Enteritidis recovery was enumerated, a significant treatment-associated reduction was observed 12 h posttreatment, although in cecal tonsil samples there was no difference in Salmonella Enteritidis incidence at 12 h (P < 0.05). In these studies, LAB treatment significantly reduced recovery of Salmonella in day-of-hatch broilers.
Carte climatique de Nice : C.N.R.S, Carte climatique détaillée de la France au 1/250 OOOe. Nice. Publiée sous la direction de Ch.-P. Péguy (1974)

Nicod Jean. Carte climatique de Nice : C.N.R.S, Carte climatique détaillée de la France au 1/250 OOOe. Nice. Publiée sous la direction de Ch.-P. Péguy. In: Annales de Géographie, t. 83, n°455, 1974. pp. 112-113.
Robust active stereo calibration (2003)

We present a calibration procedure to determine the kinematic parameters of an active stereo system in a robot-centric frame of reference. Our goal was to obtain a solution of sufficient accuracy that the kinematic model information can be used to estimate scene structure given the measured motion/position of the eye and target object's image location. We formulate our problem using canonical coordinates of the rotation group. which enables a particularly simple closed form solution. Additionally, this formulation and solution provides quantitative measures of the resulting solutions. Experiments verify that the solutions are accurate, 3D structure can be estimated from the kinematic models, and the algorithm can indicate when image errors are large enough to produce unreliable results.
Hyperbolic transmission-line metamaterials (2012)

We demonstrate how to realize an indefinite media with hyperbolic isofrequency surfaces in wavevector space by employing two-dimensional metamaterial transmission lines. We classify different types of such media, and visualize the peculiar character of wave propagation by study of the cross-like emission pattern of a current source placed in the lattice center. Our results are supported by a solution of the Kirchhoff equations, an analytical theory, and experimental data.
Evidence for the functional involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 in bone. (1992)

In the present study the involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on osteoblast-like cells and in the stimulation of in vitro bone resorption by 1,25(OH)2D3 was examined. Incubation for 24 h with 1,25(OH)2D3 potently stimulated osteocalcin synthesis by ROS 17/2.8 cells. This stimulation was inhibited (30-70% inhibition) by 25 microM of the protein kinase C (PKC) inhibitors 1-O-hexadecyl-2-O-methyl-rac-glycerol (AMG) and sphingosine without affecting basal osteocalcin synthesis. 1,25(OH)2D3-stimulated osteocalcin secretion by nontransformed isolated fetal rat osteoblasts was also inhibited (30-55%) by AMG. Also, AMG inhibited 10(-9) M 1,25(OH)2D3-induced up-regulation of vitamin D receptor in ROS 17/2.8 cells. Activation of PKC with phorbol 12-myristate 13-acetate (PMA) did not cause an increase in osteocalcin secretion, while only a small increase in cellular content of osteocalcin in ROS 17/2.8 cells was observed. Addition of PMA together with 1,25(OH)2D3 did not change the response to 1,25(OH)2D3. The PKC inhibitors were not toxic for the cells. 1,25(OH)2D3 did not stimulate diacylglycerol production in ROS 17/2.8 cells up to 5 min after administration. However, 4- and 24-h incubation with 10 nM 1,25(OH)2D3 increased phorbol ester binding in ROS 17/2.8 cells. 1,25(OH)2D3 potently stimulated bone resorption after 3 and 6 days of culture in fetal mouse long bones and calvaria. Both the PKC inhibitors AMG (25 microM) and staurosporine (50 nM) strongly inhibited (60-86% inhibition) 1,25(OH)2D3-stimulated bone resorption without affecting basal 45Ca release. These effects were not due to a cytotoxic effect of both PKC inhibitors. Nor is it likely that the effects of AMG and staurosporine are due to inhibition of cell proliferation as hydroxyurea did not affect 1,25(OH)2D3-stimulated bone resorption. The inhibition of 1,25(OH)2D3-stimulated bone resorption by PKC inhibitors suggests that besides osteocalcin synthesis PKC is also involved in other responses of 1,25(OH)2D3 in bone. 1,25(OH)2D3 does not directly activate PKC via an increase in diacylglycerol production but more likely via an increase in PKC. Together, the present study demonstrates a functional involvement of PKC in the action of 1,25(OH)2D3 in bone and bone cells which may have consequences for the development of 1,25(OH)2D3 analogs, e.g. with less hypercalcemic and relatively more antiproliferative activity.
Supplementary Figure 2 from Regulation of Apoptosis and Caspase-8 Expression in Neuroblastoma Cells by Isoforms of the <i>IG20</i> Gene (2023)

Supplementary Figure 2 from Regulation of Apoptosis and Caspase-8 Expression in Neuroblastoma Cells by Isoforms of the &lt;i&gt;IG20&lt;/i&gt; Gene
Nonperturbative resonances in periodically driven quantum wells (1993)

Energy absorption characteristics are computed for a classical and a quantum model of an infinite square well, as a function of driving amplitude and frequency. Nonperturbative resonances are observed corresponding to the replacement of states localized in phase space by more extended states. Their presence is predicted by avoided crossings in the quasienergy spectrum of the Floquet operator. The conditions under which these resonances occur can be realized in experiments on GaAs/${\mathrm{Al}}_{\mathit{x}}$${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$As quantum wells in intense far-infrared radiation.
Generalization of median root prior reconstruction (2002)

Penalized iterative algorithms for image reconstruction in emission tomography contain conditions on which kind of images are accepted as solutions. The penalty term has commonly been a function of pairwise pixel differences in the activity in a local neighborhood, such that smooth images are favored. Attempts to ensure better edge and detail preservation involve difficult tailoring of parameter values or the penalty function itself. The previously introduced median root prior (MRP) favors locally monotonic images. MRP preserves sharp edges while reducing locally nonmonotonic noise at the same time. Quantitative properties of MRP are good, because differences in the neighboring pixel values are not penalized as such. The median is used as an estimate for a penalty reference, against which the pixel value is compared when setting the penalty. In order to generalize the class of MRP-type of priors, the standard median was replaced by other order statistic operations, the L and finite-impluse-response median hybrid (FMH) filters. They allow for smoother appearance as they apply linear weighting together with robust nonlinear operations. The images reconstructed using the new MRP-L and MRP-FMH priors are visually more conventional. Good quantitative properties of MRP are not significantly altered by the new priors.
Trade-Off between High Sensitivity and Increased Potential for False Positive Peptide Sequence Matches Using a Two-Dimensional Linear Ion Trap for Tandem Mass Spectrometry-Based Proteomics (2006)

Two-dimensional linear ion trap mass spectrometers are rapidly becoming the new workhorse instruments for shotgun proteomic analysis of complex peptide mixtures. The objective of this study was to compare the potential for false positive peptide sequence matches between a two-dimensional ion trap instrument and a traditional, three-dimensional ion trap instrument. Through the comparative analysis of a complex protein sample, we found that in order to minimize false positive sequence matches, sequence match scoring criteria must be more stringent for data from the two-dimensional ion trap compared to the three-dimensional ion trap data. Given this increased potential for false positives, we also investigated two potential filtering strategies to reduce the false positive matches for data derived from the two-dimensional ion trap, including trypsin enzyme cleavage filtering, and the addition of peptide physicochemical information as a constraint, specifically peptide isoelectric point. The results described here provide a cautionary tale to researchers, demonstrating the need for careful analysis of MS/MS data from this new class of ion trap instruments, as well as the effectiveness of trypsin enzyme cleavage filtering and peptide pI information in maximizing high confidence protein identifications from this powerful proteomic instrumentation.
Development of Geodesic Composite Fuselage Structure (2014)

The paper is concerned with development of geodesic composite fuselage structure whose stiffness and strength are provided by a system of ribs made of unidirectional carbon-epoxy composite materials by continuous wet filament winding. Design and weight efficiency of the geodesic structures are discussed along with the efficiency of traditional composite stringer structures. Results of design, analysis and fabrication of a full-scale 4m diameter fuselage section are presented.
Contact pemphigus vulgaris? (1998)

A 52‐year‐old woman developed a bullous eruption on the oral mucosa at the site of contact with a nickel‐con‐taining tooth filling. The lesion was resistant to treat‐ment and persisted long after removal of the contact. Patch tests with the European standard series were posi‐tive to nickel. Biopsy and immunofluorescence indicated definite pemphigus vulgaris.
The Use of Crown Ethers in Peptide Chemistry – V. Solid‐phase Synthesis of Peptides by the Fragment Condensation Approach using Crown Ethers as Non‐covalent Protecting Groups (1996)

We have previously described the conditions by which peptide synthesis by the solid-phase fragment condensation approach can be carried out using crown ethers as non-covalent protection for the N alpha-amino group. Here we demonstrate that the procedure can be extended to large, partially protected peptide fragments possessing free Lys and/or Arg residues. The first step was to ensure that complex formation on the side chain of amino acids was not detrimental to the methodology and exhibited the same solubility and coupling properties as N alpha-complexed peptides. Thus, a model hexapeptide was synthesized using Fmoc chemistry containing Lys and Arg residues, which, when complexed with 18-Crown-6, was readily soluble in DCM and coupled quantitatively to a resin-bound tetrapeptide. Two tripeptides were then prepared, one containing a free Ser residue, the other free Tyr, to examine the possible occurrence of side reactions. After coupling using standard conditions only the former tripeptide exhibited the formation of the O-acylation by-product (5%). Another model hexapeptide containing Lys, Tyr, Ser and Asp protected with a TFA-stable adamantyl group was complexed with 18-Crown-6 and coupled to the resin-bound tetrapeptide with near quantitative yield. Extending the length of the peptide to 21 and 40 residues, which represent sequences Gly52 to Leu72 (21-mer) and Pro33 to Leu72 (40-mer) from Rattus norvegicus chaperonin 10 protein, respectively, resulted in partially protected fragments that were readily soluble in water, thus enabling purification by RP-HPLC. Complexation with 18-Crown-6 gave two highly soluble products that coupled to resin-board tetramer with 68% and 50% coupling efficiencies for the 21-mer and 40-mer, respectively. Treatment with 1% DIEA solutions followed by acidolytic cleavage and purification of the major product confirmed that the correct product has been formed, when analysed by amino acid analysis and ESI-MS. These results served to extend the methodology of non-covalent protection of large partially protected peptide fragments for the stepwise fragment condensation of polypeptides.
WE‐DE‐BRA‐02: BEST IN PHYSICS (JOINT IMAGING‐THERAPY): Prototype for An In‐Room Supercompounded 3D Volumetric Ultrasound Image Guidance System for Prone Breast SBRT (2016)

Purpose: SBRT requires both substantial positioning precision and accuracy. However, accurate dose delivery is challenging for prone breast SBRT due to breast deformation, lumpectomy cavity shrinkage and ineffective CT/CBCT on soft tissue. We developed a prototype in‐room 3D volumetric ultrasound (US) image guidance system for prone breast SBRT. Methods: The designed system, set beneath a prone breast board, consists of a customized breast cup, rotational scanning water container, and a portable US scanner. The breast CT scan is converted to STereoLithographic model then 3D printed as a mold to construct a patient‐specific breast cup. The holder is fabricated with liquid urethane resin and cured to a ∼1 mm thick semi‐rigid polymerized cup. The US transducer is attached to the container but separated from a water compartment by a urethane resin membrane. The transverse scan is acquired by simultaneously rotating the water container and transducer every 5°. The 3D US image is constructed with multiple transverse images using a supercompounding‐technique‐based volumetric US reconstruction algorithm. The performance of the prototype US system was evaluated on a gelatin based breast phantom with five embedded reflective markers. Reconstructed image quality (size and geometric accuracy) was compared with MRI images of the same phantom. Results: In the evaluated plane, the five embedded markers were compared to MRI in terms of size and location. Diameter differences were 1.85, 1.71, 2.37, 1.00 and 1.85 mm between MRI and US. The 1–2 mm variations come from the different edge response the material has on the two imaging modalities. The difference in distance between adjacent marker centers between MRI and US were 0.57, 0.84, 0.75 and 0.80 mm. Conclusion: The phantom study results show geometric agreement between MRI and US indicating that the proposed image‐guidance system can provide precise and accurate patient setup for each SBRT fraction. CPRIT Grant R1308
A mouse immunoglobulin heavy chain deletion mutant: isolation of a cDNA clone and sequence analysis of the mRNA (1980)

The mouse cell line IF2 secretes an immunoglobulin heavy chain lacking the CH1 domain. We have isolated and characterised a recombinant plasmid containing cDNA copies of the IF2 mutant mRNA. The cloned sequence extends from the nucleotides coding for amino acid 96 in the variable region through 100 nucleotides of untranslated region at the 3' end. The sequence of the cDNA insert reveals no discontinuity at the variable-hinge region junction, the site of the CH1 deletion. Experiments employing direct priming on the poly(A) tail of the IF2 heavy chain mRNA suggest that the 3' end of the cDNA clone (sequence C-C-C-T-G-C) is also the 3' end of the mRNA.
ChemInform Abstract: Synthesis, Purification and Characterization of Ionic Liquids (2010)

Abstract Review: 138 refs.
One-Pot Catalytic Epoxidation Reaction of Perfluoro-2-methyl-2-pentene with Tri-n-butylamine N-Oxide or N, N-Dimethylcyclohexylamine N-Oxide (2013)

Perfluoro epoxy compounds are important intermediates in organic chemistry, however, the methods for preparing them are scanty. We found that in situ generated tri-n-butylamine N-oxide and N,N-Dimethylcyclohexylamine N-oxide were found to be good reagents for the epoxidation of tri-substituted Perfluoro-2-methyl-2-pentene in good to excellent yields. Catalytic epoxidation methods were developed by coupling this reaction with the N-oxidation of tertiary amine by hydrogen peroxide or MCPBA. The advantages of these methods are easy work-up, mild reaction conditions, environmentally friendly and low cost. The reaction using MCPBA as a oxidant is better than hydrogen peroxide for it is fast and high yielding.
Small Molecule Crystallography in Drug Design (2001)

Crystal structures of small molecules (i.e. isolated ligands) are a source of valuable structural information helpful in the process of drug design (pharmacophore model elaborations, 3D QSAR, docking, and de novo design). Indeed, structural data obtained from small molecules crystallography can approach ligand-receptor binding by providing unique structural features both about the conformation (internal geometry) of the ligand (s) and about the intermolecular interaction potentially occurring within the active site of a target (enzyme/receptor). Small molecule crystal structure databases can also be used in three dimensional search to identify new drug candidates. Future development in small molecule crystallography (e.g. powder diffraction) should also provide original solutions to complex problems related to polymorphism.