gebhart/patrepeval huggingface dataset:
Comparative Study of the Kinetic and Structural Properties of Monomeric and Oligomeric Forms of Sarcoplasmic Reticulum ATPase1 (1984)

Sarcoplasmic reticulum (SR) isolated from rabbit muscle was treated with N-ethyl-maleimide (NEM) to specifically inhibit the dephosphorylation step of the Ca2+,Mg2+-dependent ATPase reaction. However, when this membrane was solubilized with dodecyl octaethyleneglycol monoether (C12E8), rapid decomposition of the phosphoenzyme (EP) was observed both in the absence and presence of Mg2+. When the detergent was removed from the reaction mixture, the inhibition of EP decomposition by NEM was observed again. These results support our previous suggestion (1,2) that in the presence of high concentrations of C12E8, EP may be hydrolyzed to produce P1 in a manner different from the reaction in the native SR ATPase. Gel filtration of the solubilized ATPase was performed in the presence of low concentrations of C12E8 to elute ATPase aggregates of various sizes. Two distinct fractions were selected after column chromatography and their physical and kinetic properties were compared. The molecular weights of the ATPase proteins of these two fractions were determined to be about 150 and 360K daltons with Stokes radii of about 5.5 and 8.0 nm, respectively. The Stokes radii agreed with the values obtained from polarization decay measurement data of N-1-pyrene maleimide (N-1-P)-labeled ATPase aggregates separated on the same column. The rate of EP decomposition was determined for the two column fractions described above. After the addition of EDTA the EP decomposition rate of the smaller-sized ATPase was much higher than the EP decomposition rate of the larger-sized ATPase.(ABSTRACT TRUNCATED AT 250 WORDS)
Question Answering by Reasoning Across Documents with Graph Convolutional Networks (2019)

Nicola De Cao, Wilker Aziz, Ivan Titov. Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long and Short Papers). 2019.
Pilot study of vitamin D supplementation in adults with cystic fibrosis pulmonary exacerbation (2012)

</u> In this pilot study, a single, oral bolus of cholecalciferol increased serum 25(OH)D concentrations and was associated with a trend toward improved clinical outcomes in CF subjects hospitalized for a pulmonary exacerbation. Further investigation is needed into the clinical impact of improved vitamin D status in patients with CF.
Abstract 15069: Novel Approach to Arrhythmia Risk Stratification in Patients With Cardiac Sarcoidosis Incorporating Machine Learning and a MRI-PET-Fusion Computational Model (2018)

Introduction: Clinical measures fail to correctly identify cardiac sarcoidosis (CS) patients at high risk for VT. This limits life-saving treatments, including ICDs, in high-risk patients and subje...
Autoxidation of hydroxylamine in alkaline solutions (1971)

The autoxidation of hydroxylamine in aqueous alkali is shown to proceed by attack of oxygen on a deprotonated species yielding nitroxyl ion which can be oxidised further to peroxonitrite. In the presence of a metal sequestering agent (edta) the peroxonitrite ion is stabilised, although isomerising slowly to nitrate. A little nitrite is also formed. Decrease in pH leads to increasing production of gaseous products. In the presence of catalytic metal ions, nitrite is the main product, the hydroxylamine being largely consumed via reaction with peroxonitrite. Increasing concentration of copper(II) ions resulted in increasing production of nitrous oxide. A mechanism is presented for oxygen attack on hydroxylamine and a number of other autoxidation studies on N- and O-substituted hydroxylamines discussed.
[Effect of spirobramin and prospidin on immunogenesis]. (1985)

The immunosuppressant effects of the antineoplastic piperazine drugs spirobramine and prospidin in respective doses of 500 and 600 mg/kg (1/2 of the LD50) were studied in experiments on cats. Spirobramine was shown to exert a more pronounced immunoinhibitory action on the primary and secondary immune response induced by sheep red blood cells.
Robust linear parameter-varying output-feedback control of permanent magnet synchronous motors (2021)

This paper investigates the design of a robust linear parameter-varying (LPV) controller for speed regulation of surface permanent magnet synchronous motors (SPMSMs). Motor dynamics is defined in the α–β stationary frame and a parameter-varying model formulation is provided to describe its nonlinear dynamics. A robust gain-scheduled LPV dynamic output-feedback controller is designed to guarantee the asymptotic stability and performance requirements, as well as, guarantee robustness against parameter perturbations and torque load disturbances. As a novel aspect in the SPMSM control, the real-time impact of temperature variation on the winding resistance and magnet flux during motor operation is explicitly considered in the LPV modeling as a scheduling parameter and the subsequent LPV control design compensating for demagnetization effects in the motor response. The controller synthesis conditions guaranteeing stability and robust performance to norm-bounded uncertainty in the system matrices are formulated in a convex linear matrix inequality (LMI) optimization framework. Finally, the validity of the proposed method is assessed in simulation studies. The closed-loop simulation studies demonstrate that the proposed LPV controller provides improved transient response with respect to settling time, overshoot, and disturbance rejection in tracking the velocity profile under the influence of parameter perturbation, temperature variations, and load disturbances.
Properties of Poly[methyl(n-alkyl)siloxane] and Poly[methyl(3,3,3-Trifluoropropyl)Siloxane] Monolayers Adsorbed on Water (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of Poly[methyl(n-alkyl)siloxane] and Poly[methyl(3,3,3-Trifluoropropyl)Siloxane] Monolayers Adsorbed on WaterMarianne K. Bernett and W. A. ZismanCite this: Macromolecules 1971, 4, 1, 47–53Publication Date (Print):January 1, 1971Publication History Published online1 May 2002Published inissue 1 January 1971https://pubs.acs.org/doi/10.1021/ma60019a011https://doi.org/10.1021/ma60019a011research-articleACS PublicationsRequest reuse permissionsArticle Views255Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The protein phosphatases involved in cellular regulation (1986)

The complete primary structure of inhibitor-2, a specific inhibitor of protein phosphatase-1, has been determined. The protein consists of a single polypeptide chain of 203 residues, and has a relative molecular mass of 22835 Da. This molecular mass is significantly lower than earlier estimates based on sodium dodecyl sulphate polyacrylamide gel electrophoresis. The threonyl residue phosphorylated by glycogen synthase kinase-3 is located at position 72. The molecule is very hydrophilic, lacks cysteine residues and the single tryptophanyl and phenylalanyl residues are at positions 46 and 139, respectively. The N-terminal alanyl residue is N-acetylated. Digestion with Staphylococcus aureus V8 proteinase, trypsin, or cleavage with cyanogen bromide, destroyed the biological activity of inhibitor-2, demonstrating that many large fragments (e.g. 1-49, 49-92, 67-101, 108-134, 142-182 and 163-197) are inactive. Digestion with clostripain generated a peptide comprising residues 25-114 which retained 2% of the inhibitory potency of the parent molecule. There is no sequence homology between inhibitor-2 and inhibitor-1.
Genetic risk assessment for hereditary RCC: Report from the consensus panel meeting. (2020)

615 Background: While many genes are now known to be associated with hereditary kidney cancer syndromes, there is a paucity of guidelines or uniform consensus on genetic testing for these patients. An expert panel was organized to assess who, what, when and how patients should be evaluated and what testing should be initiated. Methods: A national, multidisciplinary, panel of experts in urology, medical oncology, clinical geneticists, genetic counselors and patient advocates with background and knowledge in hereditary syndromic kidney cancer convened in person in September 2019. A renal cell carcinoma (RCC) genetic risk assessment questionnaire consisting of 52 questions was compiled prior to the meeting using modified Delphi methodology. The questions were then discussed and reviewed with uniform consensus defined as a minimum of 85% agreement in accordance with the National Comprehensive Cancer Network criteria. Results: The panel consisted of twenty-six attendees represented by urologists (43%), medical oncologist (23%), genetic counselors (13%), clinical geneticists (7%), and patient advocates (3%). The questionnaire consisted of fifty-five statements focusing on who, what, when and how genetic testing should be performed in a patient suspected of hereditary RCC syndrome. A &gt;85% agreement was reached on 30/52 statements with 18/25 (72%) achieving consensus addressing “who”, 2/6 (33%) achieving consensus in “what’ category, 2/7 (29%) in ‘when’ and 4/6 (67%) on how. The questions with least consensus were found in the “what/when?” category with only 4/13 questions with minimum 85% agreement. Specific areas of debate included an age cutoff for prompting a genetic risk assessment as well as need for familial testing in patients with variants of unknown significance. Conclusions: Despite experience of the panel in management of hereditary RCC, the consensus was reached only on 66% of genetic testing. While many issues will need to be discussed further, those statements with consensus may be used to guide physicians and patients on who, what, when and how genetic RCC risk assessment should be performed.
Molecular Cloning and Characterization of a Xanthone Prenyltransferase from Hypericum calycinum Cell Cultures (2015)

In plants, prenylation of metabolites is widely distributed to generate compounds with efficient defense potential and distinct pharmacological activities profitable to human health. Prenylated compounds are formed by members of the prenyltransferase (PT) superfamily, which catalyze the addition of prenyl moieties to a variety of acceptor molecules. Cell cultures of Hypericum calycinum respond to elicitor treatment with the accumulation of the prenylated xanthone hyperxanthone E. A cDNA encoding a membrane-bound PT (HcPT) was isolated from a subtracted cDNA library and transcript preparations of H. calycinum. An increase in the HcPT transcript level preceded hyperxanthone E accumulation in cell cultures of H. calycinum treated with elicitor. The HcPT cDNA was functionally characterized by expression in baculovirus-infected insect cells. The recombinant enzyme catalyzed biosynthesis of 1,3,6,7-tetrahydroxy-8-prenylxanthone through regiospecific C-8 prenylation of 1,3,6,7-tetrahydroxyxanthone, indicating its involvement in hyperxanthone E formation. The enzymatic product shared significant structural features with the previously reported cholinesterase inhibitor γ-mangostin. Thus, our findings may offer a chance for semisynthesis of new active agents to be involved in the treatment of Alzheimer's disease.
The emission characteristics of uranium hexafluoride at high temperatures (1976)

Relative emission measurements were made for UF6/Argon mixtures heated in a plasma torch over a range of temperatures from 800 to about 3600 K over a wavelength range from 80 to 600 nm. Total pressures were varied from 1 to approximately 1.7 atm. Similarly absorption measurements were carried out in the visible region from 420 to 580 nm over a temperature range from about 1000 to 1800 K. Total pressure for these measurements was 1.0 atm. The emission results exhibited relatively no emission at wavelengths below 250 nm over the range of temperatures investigated. At temperatures in excess of 1800 K an additional emission band centered at 310 nm appears and becomes more well defined at higher temperatures. Essentially no pressure effect was observed with respect to emission at pressures up to 1.7 atm.
Breakdown Characteristics of Oil and Paper Insulation for Very Fast Transient Voltage (2001)

This paper describes dielectric breakdown characteristics of oil and oil-impregnated paper for very fast transient (VFT) voltage. Blumlein circuits generate VFT voltages of 60 and 300 nano-seconds in pulse width that simulate disconnecting switching surges in gas-insulated switchgears. We measured breakdown voltages of needle-to-plane, plane-to-plane oil gaps and several pieces of paper between plane electrodes for VFT and lightning impulse voltages. The measured data were formulated in V-t characteristics and Weibull probability distribution. The inclination n of V-t characteristics of insulating paper is 150 which is less than n=13.7 of the plane-to-plane oil gap in the VFT time range. The shape parameters of Weibull distribution obtained in this study show that the scattering of breakdown voltages of paper is much less than that of oil.
[Laboratory tests: level of T3, T4, TSH and antithyroid gland autoantibodies in the Polish population]. (1991)

In 1986-1990 epidemiologic studies on the thyroid diseases frequency in the polish population were undertaken. During this studies the serum levels of TSH, T4, T3 and autoantibodies were estimated in more than 30 thousand people. TSH was estimated in 30749, T4 in 30928, T3 in 30621 and autoantibodies in 31265 randomly chosen people in 5 districts. We have arbitrarily established the normal range for TSH to be between 0.4-3.8 microIU/ml, for T4 4.4-12.5 micrograms% and for T3 0.9-1.95 ng/ml. The tested group has been divide in 4 subgroup: girls and boys from 1 to 15 years of age the year of the Chernobyl accident, men and women from 15 to 50 years of age at the date of the accident. TSH values in the normal range were found in 85 to 92% of the tested population, depending on the subgroup. T4 vales in the normal range were found in 85 to 92% of the tested groups. T3 vales in the normal range were found in 86 to 93% of the tested groups. The absence of any kind of autoantibodies was established in 89.7% of the tested population. TSH values was above the normal range (above 3.8 microIU/ml) in 3.4% of boys, 4.3% girls, 3.2% men and 3.8% women. TSH vales below the normal range (less the 0.4 microIU/ml) were found in 4.3% boys, 5.0% girls, 10% men and 11.2% women. T4 values above the normal range (higher then 12.5 micrograms%) were found in 12.9% boys, 12.6% girls, 4.6% men and 5.9% women.(ABSTRACT TRUNCATED AT 250 WORDS)
Vestibular Habituation Training: Specificity of Adequate Exercise (1988)

Test results in patients with positional (provoked) vertigo corroborated the necessity of selecting the exercises for each particular patient. A test battery of 19 maneuvers was used. Results of all maneuvers were found to be positive, but in various combinations, constituting several interindividually different patterns. The basic requirement of vestibular habituation training for positional vertigo is that vertigo should be elicited. Indeed it has been experimentally shown that the error situation itself is the very stimulus for compensation and adaptation to develop. Only maneuvers eliciting vertigo fulfill the requirement of adequate exercises. As the testing showed that the combinations of positive maneuvers were different from one patient to another, prior testing of the patient is necessary to prescribe adequate exercises.
Conversion of Peanut Trypsin-Chymotrypsin Inhibitor B-III to a Chymotrypsin Inhibitor by Deimination of the P1 Arginine Residues in Two Reactive Sites1 (1987)

The deimination of the arginine residues in peanut trypsin-chymotrypsin inhibitor B-III caused the disappearance of its trypsin-inhibitory activity. Peanut protease inhibitor B-III was incubated with peptidylarginine deiminase, resulting in the conversion of 2.5 mol of arginine to citrulline and in the loss of its trypsin-inhibitory activity. However, the ability of the deiminated inhibitor to inhibit chymotrypsin was as strong as before. Structural analysis of the deiminated B-III indicated that the P1 arginine residues at both reactive sites, Arg(10) and Arg(38), were completely modified to citrulline by the action of peptidylarginine deiminase, and that the Arg(60) in the C-terminal region of B-III was partially deiminated. These residues seem to be exposed on the surface of the molecule. The P1' arginine residue at the first reactive site, Arg(11), was not deiminated at all.
Thermophoretically driven water droplets on graphene and boron nitride surfaces (2018)

We investigate thermally driven water droplet transport on graphene and hexagonal boron nitride (h-BN) surfaces using molecular dynamics simulations. The two surfaces considered here have different wettabilities with a significant difference in the mode of droplet transport. The water droplet travels along a straighter path on the h-BN sheet than on graphene. The h-BN surface produced a higher driving force on the droplet than the graphene surface. The water droplet is found to move faster on h-BN surface compared to graphene surface. The instantaneous contact angle was monitored as a measure of droplet deformation during thermal transport. The characteristics of the droplet motion on both surfaces is determined through the moment scaling spectrum. The water droplet on h-BN surface showed the attributes of the super-diffusive process, whereas it was sub-diffusive on the graphene surface.
Ab Initio Study of Dehydroxylation−Carbonation Reaction on Brucite Surface (2004)

The possibility of forming magnesite from brucite crystallites, in a CO2-rich environment, has attracted large interest as a possible industrial procedure to store CO2 in the form of carbonate minerals. The reaction mechanisms responsible for such processes are, however, not very well-known. In this work we first consider the compatibility of the magnesite and brucite structures, along specific crystallographic directions. In the second part we describe the sequence of events that leads to the formation of a magnesite layer, via the dehydroxylation of brucite and consequent adsorption and diffusion of carbon complexes. To observe these thermally activated events, we employ a method recently developed in our group1,2 for finding complex reaction pathways and reproducing the related free energy surface. We find that the (11̄00) brucite surface can be dehydroxylated quite easily. The formation of vacancies in the hydroxyl layers might favor the diffusion of OH and protons through the channels between two neighboring (0001) OH planes, which characterize the brucite structure. This mechanism creates the necessary conditions for further dehydroxylation and formation of magnesite layers.
A novel approach to soluble polystyrenes functionalized by tri-n-butyltin carboxylates (2000)

The methyl esters (5 a and 5 b) of two ω-(para styryl)alkanoic acids, 3-p-styryl propionic and 5-p-styryl pentanoic acid, were respectively synthesized from 3-phenyl propionic acid and 5-phenyl pentanoic acid in four reaction steps. These esters have been submitted to radical copolymerization with styrene affording the corresponding copolymers. The methyl ester functions were subsequently converted into the tri-n-butyltin carboxylates using bis(tributyltin) oxide. This approach by-passes complications of radical polymerization inhibition due to the presence of tin in the monomers. It also avoids undesired, uncontrolled early stage polymerization of styryl moieties during the hydrolysis of the methyl esters into the corresponding carboxylic acid precursors of the monomeric tin carboxylates. Finally, it reduces significantly the polymerization time. Characterizations of the tin functionalized polymers in solution and solid state by NMR, IR and thermal techniques allow us to conclude that the tin atoms are tetracoordinated.
Speed dependence of microwave rotational relaxation rates (1980)

For most molecular systems, rotational relaxation rates depend strongly on absorber speed. The influence of this speed dependence on transient decays in the microwave region and on the measurement of rotational relaxation rates, line positions, and line shifts is described. Measurement of the speed dependence of relaxation rates may be made from the nonexponential behavior of transient decays which are more sensitive to the speed dependence than line shapes. We describe how these transient experiments may be performed using either amplitude modulation or Stark switching, how the data may be analyzed using calculations of nonexponentiality from pressure-dependent sources, and give experimental results for these transitions: OCS J=0−1 and J1–2, H2CO 212−211, NH3 (3,2), and ethylene oxide 431−422. Previous transient experiments need to be re-evaluated in terms of a speed dependent relaxation rate. The speed dependence may make the measured rate an ill-defined population average which cannot be compared to static line width measurements or to calculations.
Human Identity Verification based on Heart Sounds: Recent Advances and Future Directions (2011)

Identity verification is an increasingly important process in our daily lives, and biometric recognition is a natural solution to the authentication problem. One of the most important research directions in the field of biometrics is the characterization of novel biometric traits that can be used in conjunction with other traits, to limit their shortcomings or to enhance their performance. The aim of this work is to introduce the reader to the usage of heart sounds for biometric recognition, describing the strengths and the weaknesses of this novel trait and analyzing in detail the methods developed so far by different research groups and their performance.
In Situ Mitigation of Subsurface and Peripheral Focused Ion Beam Damage via Simultaneous Pulsed Laser Heating (2016)

Focused helium and neon ion (He(+)/Ne(+)) beam processing has recently been used to push resolution limits of direct-write nanoscale synthesis. The ubiquitous insertion of focused He(+)/Ne(+) beams as the next-generation nanofabrication tool-of-choice is currently limited by deleterious subsurface and peripheral damage induced by the energetic ions in the underlying substrate. The in situ mitigation of subsurface damage induced by He(+)/Ne(+) ion exposures in silicon via a synchronized infrared pulsed laser-assisted process is demonstrated. The pulsed laser assist provides highly localized in situ photothermal energy which reduces the implantation and defect concentration by greater than 90%. The laser-assisted exposure process is also shown to reduce peripheral defects in He(+) patterned graphene, which makes this process an attractive candidate for direct-write patterning of 2D materials. These results offer a necessary solution for the applicability of high-resolution direct-write nanoscale material processing via focused ion beams.