gebhart/patrepeval huggingface dataset:
Real-Time Stereo Matching Using Orthogonal Reliability-Based Dynamic Programming (2007)

A novel algorithm is presented in this paper for estimating reliable stereo matches in real time. Based on the dynamic programming-based technique we previously proposed, the new algorithm can generate semi-dense disparity maps using as few as two dynamic programming passes. The iterative best path tracing process used in traditional dynamic programming is replaced by a local minimum searching process, making the algorithm suitable for parallel execution. Most computations are implemented on programmable graphics hardware, which improves the processing speed and makes real-time estimation possible. The experiments on the four new Middlebury stereo datasets show that, on an ATI Radeon X800 card, the presented algorithm can produce reliable matches for 60% approximately 80% of pixels at the rate of 10 approximately 20 frames per second. If needed, the algorithm can be configured for generating full density disparity maps.
Affordable oral proinsulin bioencapsulated in plant cells regulates blood sugar levels similar to natural insulin (2023)

Diabetes Mellitus is a silent epidemic affecting >500 million, which claimed 6.7 million lives in 2021, a projected increase of >670% in <20 years old in the next two decades but insulin is unaffordable for the large majority of the globe. Therefore, we engineered proinsulin in plant cells to facilitate oral delivery. Stability of the proinsulin gene and expression in subsequent generations, after removal of the antibiotic-resistance gene, was confirmed using PCR, Southern and western blots. Proinsulin expression was high (up to 12 mg/g DW or 47.5% of total leaf protein), stable up to one year after storage of freeze-dried plant cells at ambient temperature and met FDA regulatory requirements of uniformity, moisture content and bioburden. GM1 receptor binding, required for uptake via gut epithelial cells was confirmed by pentameric assembly of CTB-Proinsulin. IP insulin injections (without C peptide) in STZ mice rapidly decreased blood glucose level leading to transient hypoglycemia, followed by hepatic glucose compensation. On the other hand, other than the 15-min lag period of oral proinsulin (transit time required to reach the gut), the kinetics of blood sugar regulation of oral CTB-Proinsulin in STZ mice was very similar to naturally secreted insulin in healthy mice (both contain C-peptide), without rapid decrease or hypoglycemia. Elimination of expensive fermentation, purification and cold storage/transportation should reduce cost and increase other health benefits of plant fibers. The recent approval of plant cell delivery of therapeutic proteins by FDA and approval of CTB-ACE2 for phase I/II human clinical studies augur well for advancing oral proinsulin to the clinic.
RFID for Food Industry 4.0 - Current Trends and Monitoring of Fruit Ripening (2022)

In the last decade, the technology-driven paradigm of Industry 4.0 has emerged as a game-changer also for the food industry. RFID can enable multiple new devices and processes accordingly, especially regarding logistics, sensing, and eco-sustainability. After the introduction of current trends of RFID for food processing and distribution, this contribution describes an ongoing project for fruit ripening monitoring as a case study for RFID-based sensing of food. The detailed system can monitor avocados at both consumer and stock levels and can estimate the ripening status with an accuracy higher than 85%.
Survival of corneal grafts after severe burns of the eye (1994)

The authors investigated 32 human corneal buttons of patients suffering from severe eye burns. The keratoplasties were performed in different periods after the burn and collected within five years. Grafts were followed-up until they failed because of ulceration or until rehabilitating keratoplasties were performed. Early (up to six months after the burn) and late (more than 12 months after the burn) obtained corneas showed different cellular reactions in the corneal stroma. Inflammatory cells such as granulocytes and lymphocytes decreased with increasing periods after the burn. More than 12 months after the burn, minor inflammatory cellular reactions but increasing scar formation could be found. Four out of 19 early-, two out of eight intermediate- (between six and 12 months after the burn) and one of the late performed keratoplasties failed and had to be replaced by new corneal grafts. Due to the conditions in the graft beds the explanted corneal grafts showed a cellular reaction in the stroma comparable to the previously explanted burnt corneae. Further complications occurred because of problems concerning the ocular surface. After preliminary therapeutical keratoplasties rehabilitating keratoplasties could be successfully performed in four cases between 19 and 39 months.
Crystal structure of tetraaqua(o-phenanthroline)cobalt(II) sulfate dihydrate, [C12H8N2 )Co(H2O)4]S04 · 2H2O (2002)

Article Crystal structure of tetraaqua(o-phenanthroline)cobalt(II) sulfate dihydrate, [C12H8N2 )Co(H2O)4]S04 · 2H2O was published on December 1, 2002 in the journal Zeitschrift für Kristallographie - New Crystal Structures (volume 217, issue JG).
Observation of magnetic forces by the atomic force microscope (1987)

We present a new way to observe the surface domain distribution of a magnetic sample at a submicrometer scale. This magnetic microscopy is based on the idea of measuring magnetic forces with the recently developed atomic force microscope (AFM). We study the magnetic forces involved in the interaction between a single-domain microtip and the sample surface magnetic domains. The influence of the experimental conditions on the performance of the AFM as a magnetic profiling device is also discussed. Preliminary experimental results are reported.
The wide range of factors contributing to Wind Resource Assessment accuracy in complex terrain (2022)

Abstract. Understanding the uncertainties of Wind Resource Assessments (WRA) is key to reducing project risks, and this is particularly challenging in mountainous terrain. In the academic literature, many complex flow sites have been investigated, but they all focus on comparing wind speeds from selected wind directions, and do not focus on the overall AEP. In this work, a range of simulations are carried out with seven different wind modelling tools at five different complex terrain sites and the results compared to wind speed measurements at validation locations. This is then extended to AEP estimations (without wake effects), showing that wind profile prediction accuracy does not translate directly or linearly to AEP accuracy. This is firstly because there is a surprisingly large variation in energy production calculation techniques between tools, and secondly because the AEP depends strongly upon the relative strength and occurrence of the wind speed in the most commonly-occurring wind direction sectors. This means that the wind model that produces the most accurate wind predictions for a certain wind direction over a certain time period does not always result in the most suitable model for the AEP estimation of a given complex terrain site. In fact, the large number of steps within the WRA process often lead to the choice of wind model being less important for the overall WRA accuracy than would suggest by only looking at wind speeds. It is therefore concluded that it is vitally important for researchers to consider overall AEP – and all the steps towards calculating it – when evaluating simulation accuracies of flow over complex terrain.
ChemInform Abstract: Trialkyl Methanetricarboxylate as Dialkyl Malonate Surrogate in Copper‐Catalyzed Enantioselective Propargylic Substitution. (2016)

Abstract The first Cu‐catalyzed enantioselective propargylation of methanetricarboxylate (II) is developed.
PPG delineator for real-time ubiquitous applications (2010)

This paper presents real-time signal processing algorithm for detection of onsets and peaks in Photoplethysmogram (PPG) waveform. Algorithm relies on the analysis of amplitude, slope and inter-beat intervals. The presented algorithm consists of four stages for characterizing PPG waveform. Preprocessing stage involves transformation of PPG since the original waveform is less impulsive and robust. In second stage, algorithm seeks for valid pulse detection in transformed signal complying with the amplitude threshold and inter-beat interval. On detection of valid pulses, algorithm then searches backward and forward in transformed signal for the detection of peaks and onsets. Further the detection parameters are made adaptive to comply with varying beat morphologies and fluctuations in baseline. All signal processing steps and decision logics are implemented with low computational complexity to make it applicable for compact ubiquitous health monitoring devices. On evaluation with our database, the algorithm achieved sensitivity of 96.89% and positive predictivity of 94.55% within an acceptance level of 12 ms.
Rethinking deduplication in cloud: From data profiling to blueprint (2011)

Cloud storage system is becoming the substantial component of the cloud system due to emerging trend of user data. Different from other computing resources, storage resource is vulnerable to the cost issue since the data should be maintained during the downtime. In this paper, we investigate the benefit and overhead when deduplication techniques are adopted to the cloud storage system. From the result, we discuss several challenges across the cloud storage. Furthermore, we suggest the cloud storage architecture and the deduplication engine to optimize the deduplication feature in the cloud storage system. We expect that our suggestions reduce the cloud storage system cost efficiently without performance degradation of data transfer.
Probing the Hardest Branching within Jets in Heavy-Ion Collisions (2017)

Heavy ion collisions present exciting opportunities to study the effects of quantum coherence in the formation of subatomic particle showers. We report on the first calculation of the momentum sharing and angular separation distributions between the leading subjets inside a reconstructed jet in such collisions. These observables are directly sensitive to the hardest branching within jets and can probe the early stage of the jet formation. We find that the leading-order medium-induced splitting functions, here obtained in the framework of soft-collinear effective theory with Glauber gluon interactions, capture the essential many-body physics, which is different from proton-proton reactions. Qualitative and in most cases quantitative agreement between theory and preliminary CMS measurements suggests that hard parton branching in strongly interacting matter can be dramatically modified. We also propose a new measurement that will illuminate its angular structure.
Comparative Analysis of Linear and Nonlinear Control of Wave Energy Converter for a Force Control Application (2020)

The aim of wave energy converters (WECs) is to harvest the energy from the ocean waves and convert into electricity. Optimizing the generator output is a vital point of research. A WEC behaves as a nonlinear system in real ocean waves and a control that approximates the behaviour of the system is required. In order to predict the behaviour of WEC, a controller is implemented with an aim to track the referenced trajectory for a force control application of the WEC. A neural model is implemented for the system identification and control of the nonlinear process with a neural nonlinear autoregressive moving average exogenous (NARMAX) model. The neural model updates the weights to reduce the error by using the Levenberg-Marquardt back-propagation algorithm for a single-input-single-output (SISO) nonlinear system. The performance of the system under the proposed scheme is compared to the same system under a PI-controller scheme, where the PI gains have been tuned accordingly, to verify the control capacity of the proposed controller. The results show a good tracking of dq (direct-quadrature) axes currents by regulating the stator currents, and hence a force control is achieved at different positions of the translator. The dynamic performance of the control is verified in a time domain analysis for the displacement of the translator.
Laser Microirradiation of Chinese Hamster Cells at Wavelength 365 nm: Effects of Psoralen and Caffeine (1981)

Thomas Cremer, Scott P. Peterson, Christoph Cremer, Michael W. Berns, Laser Microirradiation of Chinese Hamster Cells at Wavelength 365 nm: Effects of Psoralen and Caffeine, Radiation Research, Vol. 85, No. 3 (Mar., 1981), pp. 529-543
Quantum Measurement Operations with Nanomagnets and SQUIDs (1999)

The low-energy behaviour of 2 coupled nanomagnets or 2 coupled SQUIDs, interacting with their environment, can be described by the model of a ``Pair or Interacting Spins Coupled to an Environmental Sea'' (PISCES). These physical systems can then be used for a measurement operation in which system, apparatus and environment are all treated quantum mechanically. We design a ``Bell/Coleman-Hepp'' measuring system, and show that in principle one may design a situation in which quantum interference between system and apparatus can upset the usual measurement operation.
Semi-Supervised Clustering of Corner-Oriented Attributed Graphs (2006)

This paper describes a new algorithm for image semi-supervised clustering. In particular, the proposed approach introduces corner-oriented attributed graphs(COAG) constructed based on modified Harris corner extraction method to represent structure objects . 2D-Laplacianface is used to reduce the dimension of feature matrix obtained from COAG. Feature vector is built just from the output of dimensionality reduction. This vector denotes the input to the classifier. Semi-supervised k-mean clustering method (S2KMCM) is carried out as semi-clustering method. Experimental results show that COAG can preserve the structure information of image and S2KFCM can be applied to both clustering and classification tasks by labeled and unlabeled data together.
Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. (1987)

We have isolated a murine cDNA that shares extensive homology with genes encoding the src (Rous sarcoma virus oncogene)-related family of protein-tyrosine kinases. The cDNA includes an open reading frame of 1509 base pairs, and conceptual translation predicts a protein of 56 kDa. Blot-hybridization analysis indicates that this src-related gene is expressed in normal macrophages and in cell lines representing both the myeloid and lymphoid B-cell lineages and, accordingly, is designated "bmk" (B cell/myeloid kinase). In addition, bmk mRNA levels increase following the induced differentiation of the murine myelomonocytic leukemic cell line WEHI-3B.
Germany on the Road to “Normalcy”: Policies and Politics of the Red-Green Federal Government (1998–2002) (2004)

Gerhard Schröder started his campaign for reelection with a rally in his hometown of Hanover in Lower Saxony on 5 August 2002. He opened his speech with a phrase that was to become a major motif in the following weeks and months. Schröder declared that his government had set off “on our German way.”1 Albeit he may have intended to reference the domestic agenda and the Modell Deutschland, which Helmut Schmidt had introduced some 25 years earlier, Schröder surely knew that this allusion would evoke memories of the notorious pre- and interwar debates about a German Sonderweg and German exceptionalism. Schröder furthermore failed on this and other occasions to define (or perhaps deliberately avoided addressing) what he really meant by “our German way.” Yet he did make clear that this formulation was not merely empty rhetoric. He justified his refusal to support the American policy toward Iraq by referring to national interests. Schröder criticized the American strategy and the threat to wage war on Iraq if it did not comply with international and American decisions. He refused to participate in any “adventure” and stated that the “checkbook diplomacy” of the Kohl era was over. Instead the new German security and foreign policy would be based on “self-conscious solidarity” and guided by the national interests of the German people (Schröder 2002a,d).
CKM and LILRB5 Are Associated With Serum Levels of Creatine Kinase (2014)

This is the first genome-wide study to report on the underlying genetic determinants of CK variation in a population of statin users. We found statistically significant association for variants in the CKM and LILRB5 genes.
Food Authentication: Identification and Quantitation of Different Tuber Species via Capillary Gel Electrophoresis and Real-Time PCR (2020)

Truffles are hypogeous fungi mainly found in Europe and Asia. Due to their special aroma and taste, some truffle species are sold on the international market at an extremely high price. Among the economically relevant species, the white Alba truffle (<i>Tuber magnatum</i>) and the black Périgord truffle (<i>T. melanosporum</i>) are the most appreciated species. The fruiting bodies of the Asian black truffle are morphologically very similar to <i>T. melanosporum,</i> and those of the Bianchetto truffle (<i>T. albidum</i> Pico) are similar to <i>T. magnatum</i>, but are of little economic value. Highly valued species are adulterated with cheaper ones, especially. Because of this problem, the aim of this study was the development of methods for detecting possible admixtures to protect consumers from fraud. This study is based on seven different truffle species (117 fruiting bodies) from different growing regions. Additionally, selected truffle products were included. Using this material, a real-time PCR (polymerase chain reaction) assay allowing the detection and quantitation of Asian black truffles in <i>T. melanosporum</i> up to 0.5% was developed. In addition, a capillary gel electrophoresis assay was designed, which allows the identification and quantitation of different species. The methods can be used to ensure the integrity of truffle products.
Discovery of a Manduca sexta Allatotropin Antagonist from a Manduca sexta Allatotropin Receptor Homology Model (2018)

Insect G protein coupled receptors (GPCRs) have important roles in modulating biology, physiology and behavior. They have been identified as candidate targets for next-generation insecticides, yet these targets have been relatively poorly exploited for insect control. In this study, we present a pipeline of novel <i>Manduca sexta</i> allatotropin (Manse-AT) antagonist discovery with homology modeling, docking, molecular dynamics simulation and structure-activity relationship. A series of truncated and alanine-replacement analogs of Manse-AT were assayed for the stimulation of juvenile hormone biosynthesis. The minimum sequence required to retain potent biological activity is the <i>C</i>-terminal amidated octapeptide Manse-AT (6-13). We identified three residues essential for bioactivity (Thr⁴, Arg6 and Phe⁸) by assaying alanine-replacement analogs of Manse-AT (6-13). Alanine replacement of other residues resulted in reduced potency but bioactivity was retained. The 3D structure of the receptor (Manse-ATR) was built and the binding pocket was identified. The binding affinities of all the analogs were estimated by calculating the free energy of binding. The calculated binding affinities corresponded to the biological activities of the analogs, which supporting our localization of the binding pocket. Then, based on the docking and molecular dynamics studies of Manse-AT (10-13), we described it can act as a potent Manse-AT antagonist. The antagonistic effect on JH biosynthesis of Manse-AT (10-13) validated our hypothesis. The IC<sub>50</sub> value of antagonist Manse-AT (10-13) is 0.9 nM. The structure-activity relationship of antagonist Manse-AT (10-13) was also studied for the further purpose of investigating theoretically the structure factors influencing activity. These data will be useful for the design of new Manse-AT agonist and antagonist as potential pest control agents.
Key regulators of sensitivity to immunomodulatory drugs in cancer treatment (2021)

Immunomodulatory drugs (IMiDs) include thalidomide, lenalidomide, and pomalidomide, which have shown significant efficacy in the treatment of multiple myeloma (MM), myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)) and other hematological malignancies. IMiDs hijack the CRL4<sup>CRBN</sup> ubiquitin ligase to target cellular proteins for ubiquitination and degradation, which is responsible for their clinical activity in MM and MDS with del(5q). However, intrinsic and acquired resistance frequently limit the efficacy of IMiDs. Recently, many efforts have been made to explore key regulators of IMiD sensitivity, resulting in great advances in the understanding of the regulatory networks related to this class of drugs. In this review, we describe the mechanism of IMiDs in cancer treatment and summarize the key regulators of IMiD sensitivity. Furthermore, we introduce genome-wide CRISPR-Cas9 screenings, through which the regulatory networks of IMiD sensitivity could be identified.
The Impact of Technological Change (2003)

This chapter contains sections titled: New Technology Industry Impact Concluding Remarks Acknowledgments References
RNase H sequence preferences influence antisense oligonucleotide efficiency (2019)

During preparation of a follow-up manuscript, the Authors have discovered that the company which sold the commercial enzymatic preparation 'Recombinant Human RNASEH1' mislabelled the preparation.The company has confirmed that the preparation actually used a recombinant E.coli RNase H protein, not the human enzyme.That implies that whenever the Authors have discussed sequence preferences of the human RNase H1 enzyme, they were in fact unknowingly instead describing properties of the E. coli enzyme.Below is the Authors' assessment of the consequences that the reagent mislabeling has on the major conclusions in the paper.1.The novelty and validity of the H-SPA methodology are unaffected.2. As a result of the mislabeling, preferences of E. coli RNase H were independently assessed twice, using enzyme preparations from two different suppliers and using two different reaction buffers.In the manuscript the Authors write about 'strikingly similar sequence preferences of the human and E. coli enzymes', which they interpreted as stemming from structural conservation between two enzymes, but now can only be used as an example of the method's robustness and reproducibility.3. The explanation of the binding mode of the human RNase H1 to the RNA-DNA hybrid in the crystal structure, and correlation with mRNA knockdown may be a result of the structural similarity between human and bacterial enzymes, however those arguments are now significantly weaker.4. The discovered competitive inhibitor of RNase H (nicked dumbbell) is a competitive inhibitor of the bacterial enzyme, not necessarily of the human enzyme.5.The presented sequence preferences of the RNase H from HIV-1 reverse transcriptase are unaffected (figure 4).6.The presented biological implications of the sequence preferences of HIV-1 RNase H are unaffected (figure 5).