gebhart/patrepeval huggingface dataset:
Initiation of in vitro mRNA synthesis from the wild-type lac promoter. (1975)

An in vitro transcription system, dependent on catabolite gene activator protein (CAP), utilizing a 200 base-pair restriction fragment, has been used to show that the initiation site of the wild-type Escherichia coli lac mRNA, and that of two mutants, 8d and ps, are identical to that previously reported for the CAP-independent promoter mutant UV5. Order of addition experiments are used to show that the binding of lac repressor to the operator is competitive with that of the RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) to the promoter, thus demonstrating functional overlap of the operator and promoter sites.
Comparative efficacy of tigecycline VERSUS vancomycin in an experimental model of soft tissue infection by methicillin-resistantStaphylococcus aureusproducing Panton-Valentine leukocidin (2014)

Methicillin-resistant Staphylococcus aureus (MRSA) producing Panton-Valentine leukocidin (PVL) is highly virulent. This study aimed to compare the efficacy of tigecycline versus vancomycin in experimental thigh abscess by a PVL-producing MRSA isolate. One hundred and ninety-six Wistar rats were divided into five groups: group A, controls; groups B and C, administered vancomycin starting 1 and 6 h after bacterial challenge respectively; groups D and E, administered tigecycline starting 1 and 6 h after bacterial challenge respectively. Treatment was continued every 12 hours for three consecutive days. Survival was recorded; separate animals were killed for quantitative cultures. Serum samples were collected for estimation of malondialdehyde (MDA). Survival of group D was prolonged compared to all other groups. The bacterial load of blood, liver, spleen and lung was significantly decreased within group D compared to group B at 36 hours. Treatment with tigecycline was accompanied by significant reduction of serum MDA at 24 hours. Tigecycline is comparable to vancomycin for the treatment of soft tissue infections by PVL-producing MRSA.
Hypersensitive thermally-activated molecular machines: Anisotropic rotational dynamics within hierarchically ordered periodic mesoporous p-divinylbenzenesilica (2012)

The dynamics of p-phenylene-d4 rotators in hierarchically ordered periodic mesoporous p-divinylbenzenesilica have been elucidated by deuterium solid-state NMR spectroscopy. The mesoporous material, characterized by a honeycomb lattice structure, has arrays of alternating p-divinylbenzene and siloxane layers forming the ordered walls of the mesoscopic channels. NMR expts. revealed a non-Arrhenius temp. dependence of the rotator dynamics, with rates ranging from 103 to 108 Hz between 215 K and 305 K. The regime of motion changes drastically at ∼280 K, indicating a dynamical transition with a corresponding change in heat capacity. At room temp. and above, the rotators comprise a highly mobile fluid-like rotational phase within the org. layers of the walls. However, cooling slightly below room temp. results in rigid glass-like org. layers with markedly slower dynamics. Exploiting the rotational behavior, above and below the transition, represents a means to elicit a very significant thermal response within a narrow temp. range.
Synthesis of 3-substituted isocoumarins and related natural products. (1993)

Several N, N-diethyl-2-acylmethylbenzamides (6) were prepared from N, N-diethyl-2-toluamides (4), and the ketoamides (6) were easily cyclized to the corresponding 3-substituted isocoumarins (8) by heating in acetic acid or xylene. This simple procedure was applied to the synthesis of thunberginol A (1), thunberginol B (2), thunberginol F (14), and a key-intermediate (8j) for achlisocoumarin I (3).
Detection of inflow obstruction in left ventricular assist devices by accelerometer: A porcine model study (2023)

Elevated NHA provides a reliable indication of subclinical gradual inflow obstructions. The accelerometer can potentially supplement P<sub>LVAD</sub> for earlier warnings and localization of pump.
Status of silicon carbide power technology (2002)

Silicon carbide is a nearly ideal material for power switching devices and diodes. SiC has the potential to change the design, topology and circuits used in power electronics-especially where space, weight, power density and thermal management issues dominate. The compelling physical properties of SiC lead to exceptional performance: a ten fold higher breakdown voltage than silicon, ten-fold lower on-state resistance, a ten-fold higher switching speed, operational temperature and near immunity from snap-back. This paper examines the current status of SiC power semiconductor technology.
Supplemental Figure 2 from <i>Mig-6</i> Suppresses Endometrial Cancer Associated with <i>Pten</i> Deficiency and ERK Activation (2023)

&lt;p&gt;Supplemental Figure 2. Generation of overexpression &lt;i&gt;Mig-6&lt;/i&gt; and &lt;i&gt;Pten&lt;/i&gt; Ablation Mice using PR-cre mice model in the Murine Uterus.&lt;/p&gt;
Development of in vivo gene delivery system using cationic liposomes. (2000)

Cationic liposomes have been considered as a potential non-viral vector for gene delivery, which possess a low immunogenicity unlike viral vectors. The gene transfer effcieney of cationic liposomes is lower than that of viral vectors but the advance of recent study revealed to enhance the gene expression levels of cationic liposomes. The most problem of cationic liposomes seem to be the lack of organ or cell selectivity because the lung shows highest gene expression organ after intravenous injection. Applying a cell-specific targeting technology to the liposomes would improve in vivo gene delivery and reduce unexpected side effects. Liver parencymal cells and liver non-parenchymal cells exclusively express large numbers of high affinity asialoglycoprotein and mannose receptors, respectively. Receptor-mediated gene delivery systems seems to introduce foreign DNA into specific cell types in vivo. However, we have confirmed that not only the nature of the ligands grafted to carriers but also the overall physicochemical properties of the complexes need to be optimized for the cell-selective targeting of plasmid DNA. In this article, we attempt to evaluate the the gene delivery system based on the physicochemical properties of plasmid DNA and plasmid DNA/cationic liposomes or glycosylated cationic liposomes.
Smart Coating Based on Urea-Formaldehyde Microcapsules Loaded with Benzotriazole for Corrosion Protection of Mild Steel in 3.5 % NaCl (2018)

Urea-formaldehyde (UF) microcapsules loaded with linseed oil (LO) and benzotriazole (BTA) as core materials have been synthesized by in situ emulsion polymerization. The capsules were characterized by FTIR spectroscopy and particle size analysis. Surface morphology of the microcapsules was analyzed using scanning electron microscopy (SEM). The microcapsules were incorporated into epoxy resin and coated on a mild steel substrate to form a corrosion resistant organic coating. The self-healing property of coatings loaded with different weight % of microcapsules containing LO + BTA was tested by immersion of the UF coated mild steel specimens in 3.5 wt % NaCl solution. It was analyzed through visual inspection, weight loss measurements, and SEM of the scribed region of coating. It was observed that the addition of microcapsules enhances the corrosion resistance of the scratched samples.
Diagrammatic Monte Carlo for correlated fermions (2010)

We show that Monte Carlo sampling of the Feynman diagrammatic series (DiagMC) can be used for tackling hard fermionic quantum many-body problems in the thermodynamic limit by presenting accurate results for the repulsive Hubbard model in the correlated Fermi liquid regime. Sampling Feynman's diagrammatic series for the single-particle self-energy we can study moderate values of the on-site repulsion (U/t 4) and temperatures down to T /t = 1/40. We compare our results with high temperature series expansion and with single-site and cluster dynamical mean-field theory.
Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation (2018)

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are open, resulting in a sustained depolarizing current. By genetically manipulating the in vivo expression of molecular components of the MET apparatus, we show that during pre-hearing stages the MET current is essential for establishing the electrophysiological properties of mature inner hair cells (IHCs). If the MET current is abolished in adult IHCs, they revert into cells showing electrical and morphological features characteristic of pre-hearing IHCs, including the re-establishment of cholinergic efferent innervation. The MET current is thus critical for the maintenance of the functional properties of adult IHCs, implying a degree of plasticity in the mature auditory system in response to the absence of normal transduction of acoustic signals.
Impact of Phase Noise on Uplink Cell-Free Massive MIMO OFDM (2023)

Cell-Free massive MIMO networks provide huge power gains and resolve inter-cell interference by coherent processing over a massive number of distributed instead of co-located antennas in access points (APs). Cost-efficient hardware is preferred but imperfect local oscillators in both APs and users introduce multiplicative phase noise (PN), which affects the phase coherence between APs and users even with centralized processing. In this paper, we first formulate the system model of a PN-impaired uplink Cell-Free massive MIMO orthogonal frequency division multiplexing network, and then propose a PN-aware linear minimum mean square error channel estimator and derive a PN-impaired uplink spectral efficiency expression. Numerical results are used to quantify the spectral efficiency gain of the proposed channel estimator over alternative schemes for different receiving combiners.
Full-scale testing of a damaged reinforced concrete frame in fire (2012)

Fires are a relatively likely event following earthquakes in urban locations and in general are an integral part of the emergency response strategies, which are focused on life safety in most developed economies. Similarly, building regulations in most countries require engineers to consider the effect of seismic and fire loading on structures to provide an adequate level of resistance to these hazards; however, this is only on a separate basis. To the authors' knowledge there are no current regulations that require buildings to consider these hazards in a sequential manner to quantify the compound loading and design for the required resistance. This paper provides a first and early report from a novel set of tests on a full-scale reinforced concrete frame subjected to simulated earthquake and fire loads. The results from the first test indicate that the test frame could withstand a pre-damage corresponding to a seismic performance level and subsequent 1 h fire exposure without collapse. Important observations have been made about the development of temperatures and displacements in the various structural elements during the mechanical loading and subsequent fire excursion.
Synthesis and Fluorescence Properties of Europium-Substituted Lanthanum Orthophosphate and Condensed Phosphates (2012)

Mixtures of lanthanum oxide, europium oxide, and phosphoric acid were heated with various ratios of P/(La + Eu) and Eu/(La + Eu). The obtained phosphates were estimated using XRD patterns, FT-IR spectra, and SEM images. The fluo-rescence spectra and resistance against hydrofluoric acid were estimated as functional properties of these phosphate materials. The condensed phosphates showed a strong peak at 615 nm and high resistance against hydrofluoric acid.
On the Manipulation of Large Flexible Structural Modules by Robots Mounted on Large Flexible Structures (2005)

Future large space structures (LSS) will be constructed on orbit by assembling large subassemblies using teams of robots. Here, the challenging task of the control and planning of the cooperative manipulation of large flexible structural modules by such teams is addressed. The robots are mounted on the compliant LSS while moving a module to its pre-assembly position. The objective is to position the module accurately and to minimize the induced vibration in the large structure and the module. A method is developed to control the forces applied by the robots to the module and their support structures, which exploits robot cooperation and redundancy. The method is evaluated using simulations.
Real-Time Burst-Mode Operation of an Integrated SOA-PIN/TIA Receiver for 25 Gbit/s/λ and Faster T(W)DM-PON (2017)

First real-time 25-Gbit/s burst-mode operation of an integrated SOA-PIN/TIA receiver for future generation T(W)DM-PON is presented. The device has a 2.7-dB better sensitivity than APD photoreceiver and 13-dB better than PIN photoreceiver at this bitrate.
Prostate Cancer: Incremental Value of Endorectal MR Imaging Findings for Prediction of Extracapsular Extension (2004)

A model containing endorectal MR imaging findings has a significantly larger area under the ROC curve than a model containing only clinical variables; thus, endorectal MR imaging findings add incremental value in the prediction of ECE.
Corrigenda (1994)

U. Kragl, A. Gödde, C. Wandrey, N. Lubin, C. Augé, M. Scobie, M. F. Mahon, M. D. Threadgill, G. Guillerm and M. Gâtel, J. Chem. Soc., Perkin Trans. 1, 1994, 909 DOI: 10.1039/P19940000909
Mudança ou substituição de paradigma na educação pré-escolar sueca? (1970)

O artigo analisa as reformas recentes na educação pré-escolar da Suécia. Será o educare, marca da pré-escola sueca, desafiado por ideias focadas sobretudo na preparação escolar e na empregabilidade futura? Este artigo analisa as mudanças de objetivos, de instrumentos de política e de contexto, a partir de uma perspetiva histórica. A conclusão é a de que a reforma efetuada tem de ser interpretada tanto em relação às ideais nacionais como em relação às ideias defendidas por organizações internacionais. A aplicação dos requisitos de Hall (1993) para a mudança de paradigma indicia mudanças de primeira e de segunda ordem, mais do que uma alteração simultânea de objetivos, instrumentos de política e de contexto. Será necessária pesquisa adicional para melhor compreender o que realmente está a acontecer em contexto local, uma vez que políticas e práticas raramente se sobrepõem na totalidade.
Fracture of a polyimide–elastimide posterior chamber intraocular lens following blunt orbital trauma (2019)

To our knowledge, this is an uncommon report of an implanted posterior chamber polyimide-elastimide intraocular lens fracture following blunt orbital trauma. Intraocular lens exchange and fixation had successful optical and anatomical results.
Hydrogen Fuel Production from Propane in Gliding Arc Discharge (2007)

&lt;div class="htmlview paragraph"&gt;Reforming characteristics and optimal operating condition for hydrogen-rich gas production were studied by using gliding arc plasma with a catalytic reactor. Parametric screening studies were carried out for variations of the following variables: vapor flow ratio, CO&lt;sub&gt;2&lt;/sub&gt; flow ratio, reactant flow rate and input electric power. When these variables were 0.65, 0.14, 14 L/min and 1.37 kW, respectively, the production of hydrogen-rich gas was maximized with an optimal propane conversion rate of 62.6-. Under these optimal conditions, the following syngas concentrations were determined: H&lt;sub&gt;2&lt;/sub&gt;, 44.4%; CO, 18.2%; CH&lt;sub&gt;4&lt;/sub&gt;, 11.2%; C&lt;sub&gt;2&lt;/sub&gt;H&lt;sub&gt;2&lt;/sub&gt;, 2.7%; C&lt;sub&gt;3&lt;/sub&gt;H&lt;sub&gt;6&lt;/sub&gt;, 1.9%; C&lt;sub&gt;2&lt;/sub&gt;H&lt;sub&gt;4&lt;/sub&gt;, 0.6%; and C&lt;sub&gt;3&lt;/sub&gt;H&lt;sub&gt;4&lt;/sub&gt;, 0.4%. The carbon dioxide conversion rate was 29.2% and the H&lt;sub&gt;2&lt;/sub&gt;/CO ratio was 2.4.&lt;/div&gt;
COMPUTING TRANSPORT PROPERTIES OF HETEROGENEOUS MEDIA BY AN OPTIMIZATION METHOD (2005)

The problem of computing the effective transport and mechanical properties of disordered materials, modeled by random or correlated percolation networks, is studied as an optimization problem. We show that calculating an optimal distribution of the potentials (voltages, displacements, etc.) throughout a disordered material that minimizes its total energy reduces the computation times for calculating the effective properties by a factor that depending on the morphology of the system, ranges from 3 to 73. Hence, this offers significant speed-up over the most efficient numerical methods currently available.
Li-ion and Na-ion insertion into size-controlled nickel hexacyanoferrate nanoparticles (2014)

The influence of particle size on the electrochemical properties of guest-ion storage materials has attracted much attention because of the extensive need for long cycle-life, high energy density, and high power batteries. The present work describes a systematic study of the effect of particle size on the guest-ion storage capabilities of a cyanide-bridged coordination polymer. A series of nickel hexacyanoferrate particles ranging from approximately 40 to 400 nm were synthesized by a co-precipitation method and were used as the cathode material for both Li-ion and Na-ion insertion/extraction experiments using organic electrolyte. A large polarization was observed for the largest particles during Li-ion cycling, indicating a heterogeneous ion concentration within the lattice. As a consequence, the available capacity of Li-ion intercalation at high rates is significantly improved by reducing the particle size. On the other hand, Na-ion intercalation shows excellent rate capability regardless of the particle size.
Precise Simulated Percentiles in a Pinch (1991)

Abstract A percentile point simulation algorithm is presented. The algorithm is useful when computer storage and time considerations are at a premium. The algorithm employs various time- and storage-saving ideas, including a “pinching” mechanism that reduces the proportion of simulated values stored as the number of iterations is increased. Algorithm output includes a measure of precision as well as the simulated percentile point. The simulation can be stopped when the desired degree of precision has been attained.
On the Scalability of Centralized Control (2005)

Scalability of clusters and MPPs is typically discussed in terms of limits on growth: something which grows at a rate of O(logp) (where p is the number of processors) is said to be more scalable than something whose growth rate is O(p). But in practice p does not grow without limits. We therefore suggest that discussions of scalability should take time into account. System sizes grow with time, so larger systems need to be supported - but only after some time. And in particular, there is no real need to support arbitrarily large systems right now. Surprisingly, when time is thus put into the picture, we find that centralized control is actually quite scalable. The reason is that the capabilities of a centralized control node grow at a fast pace due to Moore's law. This seems to be more than enough in order to manage current growth patterns displayed by parallel systems.
The Regulation of Thymidine Secretion by Macrophages (1979)

The secretion of thymidine by mononuclear phagocytes was correlated with the activity of the enzyme thymidine kinase (TK). Macrophages cultured in regular tissue culture medium released thymidine and did not express TK. However, when macrophages were incubated with medium conditioned by L cells, they expressed TK, incorporated 3H thymidine into trichloroacetic acid precipitable material, and ceased to secrete the nucleotide. Furthermore, replicating P388/D1 cells were induced to secrete thymidine by inhibiting TK with d-glucosamine. These results have demonstrated an inverse relationship between thymidine secretion and the expression of TK. They suggest that thymidine secretion by macrophages may be attributed to their lack of TK activity.
Duplex mode selection for device-to-device communications underlaying the cellular uplink (2017)

Device-to-device (D2D) communications, which enable nearby mobile devices to communicate with each other, have drawn significant research interests. To further improve the spectral efficiency of D2D communications, we integrate full-duplex (FD) into D2D communications. Since the residual self-interference (SI) will limit the performance gain introduced by the FD mode, we cannot directly determine which duplex mode should be used. Therefore, this paper investigates the duplex mode selection problem for D2D communications underlaying the cellular uplink. Two cases are considered, i.e., the base station (BS) has perfect instantaneous channel state information (CSI) of both cellular link and D2D link and the BS only has user location information. For each case, we give the conditions to use D2D communications and investigate the existence of feasible solutions. When the feasible solutions of both FD mode and HD mode exist, we use power control to further improve system performance and give the duplex mode selection scheme. Numerical results show that the mode selection scheme is determined by the rate requirements and the residual self-interference.
Prostate Cancer Probability after Total PSA and Percent Free PSA Determination (1998)

The diagnostic performance of the percent free PSA value is enhanced when the methodological variability is reduced, particularly in men with low total PSA. Percent free PSA is superior to total PSA in distinguishing primary CaP from BPH in patients with total PSA between 2 and 30 ng/mL. The percent free PSA value is effective in reducing the rate of unnecessary biopsies in men with total PSA higher than 4 or 10 ng/mL. However, due to its relatively low post-test probability, the percent free PSA value should be interpreted with caution in the decision-making related to individual patients and should be used in association with clinical and instrumental evaluation of the patient.
Geochemical behavior of lead in an alfisol and an ultisol at high leveis of contamination (1996)

Abstract The behavior of Pb in the A and B horizons of an Alfisol from Michigan and an Ultisol from Virginia was studied to determine the effects of “shock”; loading. Combined sequential extraction‐sorption isotherm analysis (CSSA), a relatively new and little tested method, was used in the study. After spiking to simulate severe contamination (∼3000 to 60,000 mg/kg), CSSA revealed unexpectedly high levels of exchangeable Pb in the A horizon of the Alfisol and in both horizons of the Ultisol, and showed that the sorption capacities of the phases commonly responsible for fixation of Pb at low to moderate levels of contamination were exceeded. Carbonate sorbed the bulk of the Pb in the Alfisol B horizon and has a high sorption capacity in both soils, despite the presence of other phases with a strong affinity for Pb. Thus, when shock loading occurs (e.g., at a shooting range or dump sites), the highly contaminated A horizons of both soils are expected to pose a serious toxic hazard to humans, and groundwater contamination is possible in association with the Ultisol. CSSA proved useful for determining the sorption capacities of the individual phases while together in a natural soil system and therefore is a valuable method for predicting the attenuation capabilities of soils.