gebhart/patrepeval huggingface dataset:
Elastic velocity and Q factor measurements on Apollo 12, 14, and 15 rocks. (1972)

The Rayleigh wave velocities (vR) in one Apollo 12, one Apollo 15, and two Apollo 14 rocks were measured by the impulse technique. For 14310 vR = 1.20 km/sec; for 14321 vR = 0.9 km/sec; for 12063, on which the orientation dependence was studied, vR = 1.16-1.59 km/sec; for 15555 vR = 0.32 km/sec; and for synthetic rock 10017 analogue vR = 2.26 km/sec. This represents a larger spread by a factor of 3 than previously reported on lunar igneous rock. Absolute Q factor measurements were performed on one Apollo 14 rock by the vibrating bar technique. Under exposure to high vacuum and low temperatures, the Q factor is shown to increase towards values approaching the low end of the range of estimates from seismic data.
Charte graphique et site web du GIS APIVALE (2019)

Année de la première version : 2019Mode de diffusion : service en ligne
Serum LH Levels in Prepubertal Female Pigs Chronically Treated with Synthetic Luteinizing Hormone-Releasing Hormone/Follicle-Stimulating Hormone-Releasing Hormone (LH-RH/FSH-RH)123 (1973)

A double—antibody radioimmunoassay utilizing a heterologous system specific for porcine luteinizing hormone (PLH) has been developed with rabbit antibovine LH serum as a first antibody. Porcine LH (LER-786-3) was used for iodination and as a reference standard. Reliable estimates of LH could be obtained in 200 pi of serum from immature pigs at any time. Porcine follicle-stimulating hormone (FSH), porcine thyroid- stimulating hormone, porcine adrenocorticotropic hormone or serum components per se did not affect measurements of LH. Ten prepubertal female pigs (mean wt 12.8 kg) were assigned randomly in equal numbers to a treated or control group. Treatment consisted of 16 im injections of 25 ng of pure synthetic LH and FSH releasing hormone (LH-RH/FSH-RH) in one ml of acidified saline or acidified saline only at 6–hr intervals over a period of 96 hr for treated and control animals respectively. Blood samples were collected via indwelling jugular catheters, at various times following each injection. Serum LH concentrations were observed to peak at IS or 30 min following each LH-RH/FSHRH injection and return to basal levels between 120 and 240 min post-treatment. The mean peak LH level of treated animals was 6.4 ± 0.4 ng/ml compared with the mean basal level of 1.6 ± 0.1 ng/ml for control animals. The LH responses were significantly greater following the first and second injections (16.2 and 9.2 ng/ml) compared with the mean peak LH response of subsequent injections (5.5 ng/ml). No significant differences were observed either in the mean pituitary LH content (90.0 ± 34.4 vs 121.2 ± 36.4 μg/pit.) or concentration (5.5 ± 1.6 vs 7.0 ± 1.8 μg/mg) between the treated and the control animals. Chronic treatment with LH-RH/FSH-RH did not result in any significant difference in the LHreleasing activity of pig stalk median eminence 24 hr post—treatment when tested in estrogenprogesterone pretreated ovariectomized rats. There was no significant difference in the /mean diameter of the largest non—atretic ovarian follicle between treated and control animals (1.9 ± 0.6 vs 1.3 ± 0.6 mm). (Endocrinology92: 55, 1973)
Rule induction for incomplete information systems (2005)

We proposed a modified rule generation algorithm (MRG) to generate a minimal set of rule reducts and proposed a generalized rule generation algorithm (MRGI) to generate a minimal set of rule directly from the original incomplete information system. Based on MRGI, with each rule reduct represents a unique decision rule. We developed a rule generation and rule induction prototype (RGRIPI) to extract certain rules directly from the incomplete information system. RGRIPI can automatically generate a minimal set of decision rules directly from an incomplete data set. We build a probability function combining the plausibility and probability of missing values to compute the possible rules for incomplete information systems.
MULTI-MILLION PARTICLE MOLECULAR DYNAMICS ON THE CM-5 (1993)

We outline a recently developed short-range molecular dynamics (MD) algorithm for message-passing MIMD computers. Timings and performance numbers are presented for a code, SPaSM, which implements the algorithm on the Connection Machine-5 (CM-5). We demonstrate that runs with more than 10 8 particles are now possible on massively parallel MIMD computers. The speed of the code scales linearly with the number of processors and with the number of particles and shows 95% parallel efficiency in the speedup. Recent results from 2D simulations of fracture dynamics are also presented
Active click (2001)

"Active Click" is a new interface mechanism for addling tactile feedback to touch panels. A small actuator is attached to a body of PDA or the backside of a touch panel. The tactile feedback, created by driving the actuator with a short pulse, is perceived by the grasping hand or tapping finger-tip when the panel is tapped. Active Click is effective in improving the input speed of touch panel operation especially in noisy situations. Active click is also useful for large touch panel devices such as public information terminals or ATMs.
Microtubule reassembly in surface-activated platelets (1985)

It is generally accepted that a circumferential microtubule supports the discoid shape of resting platelets. The fate of the many-coiled polymer following platelet activation, however, has been a subject of considerable debate. Morphological investigations have suggested that the circumferential coils are constricted into tight rings around centrally concentrated organelles during platelet shape change. Biochemical studies employing colchicine-binding assays, on the other hand, have indicated that the bundle of microtubules dissolves almost completely within seconds after activation and reassembles in a new location one to four minutes later. The present study has accepted the latter hypothesis in order to examine the second part of the disassembly-reassembly theory proposed in biochemical studies. Platelets exposed to low temperatures sufficient to remove all microtubules were placed on glass slides and microscope grids to cause surface activation during rewarming. The combined stimuli of rewarming and surface activation might have been expected to cause more rapid assembly than warming alone or activation alone. This was not the case. Reassembly of microtubules during rewarming and simultaneous surface activation was not accelerated. In contrast to the constriction of microtubule rings observed during activation in control platelets, the diameters of coils that developed in chilled platelets one to two hours after rewarming and surface activation were twice those of control cells.
Impact of a High Loading Dose of Atorvastatin on Contrast-Induced Acute Kidney Injury (2012)

A single high loading dose of atorvastatin administered within 24 hours before CM exposure is effective in reducing the rate of CIAKI. This beneficial effect is observed only in patients at low to medium risk.
Silica‐Immobilized Highly Dispersed Oxo–Rhenium and its Catalytic Activity for the Direct Synthesis of Nitrones (2010)

Abstract A novel covalently attached silica‐immobilized oxo–rhenium catalyst was prepared by the reaction of perrhenic acid and 3‐chloropropyl functionalized mesoporous SBA‐15, in which the oxo–rhenium species is chemically bonded to the support, preventing leaching. The prepared silica‐immobilized oxo–rhenium was found to be an efficient and recyclable catalyst for the one‐pot condensation/oxidation of aldehydes and primary amines to nitrones in high yields using urea–hydrogen peroxide as a terminal oxidant under mild reaction conditions.
Classical and Object-Oriented Software Engineering With Uml and Java (1999)

From the Publisher:
This text provides an introduction to the process of software engineering. The revision concentrates on updating the book to reflect the most current trends and innovations in the field. The Universal Modeling Language (UML) has become an industry standard and now permeates this new edition. In this text, it is used for object-oriented analysis and design as well as when diagrams depict objects and their interrelationships. Design patterns, frameworks and software architecture have also become a popular topic in the field of software engineering and are part of a new chapter on reuse, portability, and inoperability. The inoperabilty material includes sections on such hot topics as OLE, COM, and CORBA (you'll want to mention that this material is covered). Some material from the 3rd edition has been reorganized into a new chapter on planning and estimating, including feature points and COCOMO II. While the text has been updated, the traditonal features which have defined the previous three editions of Schach's book have been retained. These include a balanced coverage of the object-oriented model along with the classical model (as reflected in the title) and an emphasis on metrics. The special considerations of object-oriented life-cycle models, object-oriented analysis, and object-oriented design are also retained in this edition.
Novel Synthetic Dermal Fillers Based on Sodium Carboxymethylcellulose: Comparison with Crosslinked Hyaluronic Acid-Based Dermal Fillers (2007)

The data here demonstrate that it is possible to duplicate the rheologic properties of commercial XLHA fillers using CMC/PEO at different polymer concentrations to formulate improved dermal fillers. All of the dermal filler formulations prepared can be easily injected through 30-gauge needles.
2'-Deoxy-3'-O-(4-benzoylbenzoyl)- and 3'(2')-O-(4-benzoylbenzoyl)-1,N6-ethenoadenosine 5'-diphosphate, fluorescent photoaffinity analogs of adenosine 5'-diphosphate. Synthesis, characterization, and interaction with myosin subfragment 1 (1987)

Two new fluorescent nucleotide photoaffinity labels, 3'(2')-O-(4-benzoylbenzoyl)-1,N6-ethenoadenosine 5'-diphosphate (Bz2 epsilon ADP) and 2'-deoxy-3'-O-(4-benzoylbenzoyl)-1,N6-ethenoadenosine 5'-diphosphate [3'(Bz2)2'd epsilon ADP], have been synthesized and used as probes of the ATP binding site of myosin subfragment 1 (SF1). These analogues are stably trapped by the bifunctional thiol cross-linker N,N'-p-phenylenedimaleimide (pPDM) at the active site in a manner similar to that of ATP [Wells, J.A., & Yount, R.G. (1979) Proc. Natl. Acad. Sci. U.S.A. 76, 4966-4970], and nonspecific photolabeling can be minimized by removing free probe by gel filtration prior to irradiation. Both probes covalently photoincorporate with high efficiency (40-50%) into the central 50-kDa heavy chain tryptic peptide, as found previously for the nonfluorescent parent compound 3'(2')-O-(4-benzoylbenzoyl)adenosine diphosphate [Mahmood, R., & Yount, R.G. (1984) J. Biol. Chem. 259, 12956-12959]. The solution conformations of Bz2 epsilon ADP and 3'(Bz2)-2'd epsilon ADP were analyzed by steady-state and time-resolved fluorescence spectroscopy. These data indicated that the benzoylbenzoyl rings in both analogues were stacked over the epsilon-adenine ring. The degree of stacking was greater with the 2' isomer than with the 3' isomer. Fluorescence quantum yields and lifetimes were measured for Bz2 epsilon ADP and 3'(Bz2)2'd epsilon ADP reversibly bound, stably trapped, and covalently photoincorporated at the active site of SF1. These values were compared with those for 3'(2')-O-[[(phenylhydroxymethyl)phenyl]carbonyl]-1,N6-ethenoadenos ine diphosphate (CBH epsilon ADP) and 2'-deoxy-3'-O-[[(phenylhydroxymethyl)phenyl]carbonyl]-1,N6- ethenoadenosine diphosphate [3'(CBH)2'd epsilon ADP]. These derivatives were synthesized as fluorescent analogues of the expected product of the photochemical reactions of Bz2 epsilon ADP and 3'(Bz2)2'd epsilon ADP, respectively, with the active site of SF1. The fluorescence properties of the carboxybenzhydrol derivatives trapped at the active site by pPDM were compared with those of the Bz2 nucleotide-SF1 complexes. These properties were consistent with a photoincorporation mechanism in which the carbonyl of benzophenone was converted to a tertiary alcohol attached covalently to the protein. The specific, highly efficient photoincorporation of Bz2 epsilon ADP at the active site will allow it to be used as a donor in distance measurements by fluorescence resonance energy transfer to acceptor sites on actin.
Antisense‐mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first‐in‐human randomized, placebo‐controlled trial (2015)

SPC5001 treatment dose-dependently inhibited PCSK9 and decreased LDL-C concentrations, demonstrating human proof-of-pharmacology. However, SPC5001 caused mild to moderate injection site reactions and renal tubular toxicity, and clinical development of SPC5001 was terminated. Our findings underline the need for better understanding of the molecular mechanisms behind the side effects of compounds such as SPC5001, and for sensitive and relevant renal toxicity monitoring in future oligonucleotide studies.
(100) Effect of Cropload, Irrigation, and Fertilization on Yield and Postharvest Bitter Pit Incidence of `Honeycrisp' Apple (2006)

A factorial field experiment was conducted at the New York State Agricultural Experimental Station in Geneva, N.Y., during 2004 and 2005 with `Honeycrisp' apple trees on M.9 rootstock. The main plot factors were three levels of applied nitrogen (0 kg/ha, 50 k/ha, and 100 k/ha); three levels of applied K 2 O (0 k/ha, 100 kg/ha, and 200 kg/ha); ± foliar nutrient sprays containing N, B, Zn, and Mg, ± foliar sprays of CaCl 2 and ± trickle irrigation. The subplot factor was cropload (3, 6, 9, 12, and 15 fruits/cm 2 TCA). Trees receiving irrigation or potassium had higher yields and the effect was greater as cropload was increased. There was no effect of nitrogen fertilization, foliar Ca, and foliar N, B, Zn, and Mg on yield. Irrigation and increased potassium fertilization rate reduced fruit soluble solids at harvest. Foliar calcium applications, foliar N, B, Zn, and Mg applications, and nitrogen fertilization rate did not affect fruit soluble solids at harvest. No treatment factor had an effect on fruit firmness at harvest, but, after 4 months on cold storage, fruits from irrigated trees had greater firmness. Bitter pit incidence was lower on apples from trees that did not receive irrigation compared to irrigated trees. The difference was constant under all cropload levels. Foliar calcium applications, foliar N, B, Zn, and Mg applications, nitrogen fertilization rate and potassium fertilization rate did not affect bitter pit incidence.
Accelerating Polyketide Synthase Engineering for High TRY Production of Biofuels and Bioproducts - CRADA 474 (2021)

Create a game-changing technology platform for engineering PKSs, which will greatly benefit the industrial biological production of chemicals and fuels from cellulosic biomass.
Highly tunable metal–organic frameworks with open metal centers (2008)

We report the synthesis and characterization of porphyrin containing metal–organic frameworks that show high metal tunability without altering the framework topology.
Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network (2011)

These findings highlight the importance of conserving structural rigidity of the binding loop in addition to optimising protease/inhibitor contacts when re-engineering canonical serine protease inhibitors.
A New Fast Motion Estimation Algorithm Based on H.264 (2009)

The block motion estimation is a very time consuming part in the H.264 video coding standard. Although many fast motion estimation algorithms have been proposed to reduce the huge calculation complexity instead of full search, the motion estimation time still can not satisfy the critical real-time application. This paper proposes a new fast motion estimation algorithm, which improves on the UMHexagonS algorithm. Firstly, the introduction of a new square pattern takes the place of the 5 x 5 spiral search to reduce the search point. Secondly, the multi-hexagon-grid search is replaced by a multi-octagon-gird search in order to reduce the computational complexity and effectively predict the optimal motion vector. Thirdly, by increasing the conditions and type of patterns, the proposed algorithm can adaptively adopt directional search patterns for different block types to accelerate the search speed. The simulation experimentation results show that the proposed algorithm can reduce 30%-40% of the computational complexity compared with the UMHexagonS algorithm without loss of its coding accuracy.
The α4β7 integrin binds HIV envelope but does not mediate bystander killing of γδ T cells (2012)

To the editor:

Our previous study showed HIV envelope glycoprotein induces killing of CD4-negative Vγ2Vδ2 (referred as Vδ2) T cells by binding to CCR5 and α4β7.[1][1] Blocking either CCR5 with receptor antagonists or α4β7 with MAdCAM1 reduced Env binding and killing of Vδ2 cells. Signaling
Strong coupling at room temperature in ultracompact flexible metallic microcavities (2013)

Strong coupling between metallic microcavity modes and inorganic quantum well (QW) excitons at room temperature is observed in an ultracompact flexible sample design less than 100 nm thick. Four GaAs QWs embedded in a 65 nm AlGaAs/GaAs cavity are sandwiched between gold mirrors. The strong electromagnetic confinement and metallic phase shifts provide substantial local field enhancement and angular-resolved reflectivity spectra clearly show the anti-crossing in the dispersion relation resolving a Rabi splitting of 21 meV at room temperature, in good agreement with calculations. Flex-tuning metal thin foil microcavities demonstrate new possibilities for tunable optoelectronics and the study of polaritonic micromechanical effects.
In vitro Induction of Myeloid Leukemia–Specific CD4 and CD8 T Cells by CD40 Ligand – Activated B Cells Gene Modified to Express Primary Granule Proteins (2005)

The primary granule proteins (PGP) of myeloid cells are a source of multiple antigens with immunotherapeutic potential for myeloid leukemias. Therefore, we developed a method to induce T-cell responses to PGP protein sequences. We found that gene-transfected antigen-presenting cells efficiently expand functionally competent PGP-specific CD4 and CD8 T cells. The system was optimized using T-cell responses to autologous CD40-activated B cells (CD40-B) transfected with a cytomegalovirus pp65-encoding expression vector. To generate leukemia-specific T cells, expression vectors encoding the PGP proteinase 3 (PR3), human neutrophil elastase, and cathepsin-G were transfected into CD40-B cells to stimulate post-allogeneic stem cell transplantation T cells from five patients with myeloid and three with lymphoid leukemias. T-cell responses to PGP proteinase 3 and human neutrophil elastase were observed in CD8+ and CD4+ T cells only in patients with myeloid leukemias. T-cell responses against cathepsin-G occurred in both myeloid and lymphoblastic leukemias. T cells from a patient with chronic myelogenous leukemia (CML) and from a posttransplant CML patient, expanded against PGP, produced IFN-gamma or were cytotoxic to the patient's CML cells, demonstrating specific antileukemic efficacy. This study emphasizes the clinical potential of PGP for expansion and adoptive transfer of polyclonal leukemia antigen-specific T cells to treat leukemia.
Erving Seemed Surprised at How Little “Power” Came with the ASA Presidency, and Noted that the Position of Secretary Carried Much More Clout (2013)

Dr. James F. Short, Professor Emeritus at the Washington State University, wrote this memoir at the request of Dmitri Shalin and gave his permission to post it in the Erving Goffman Archives.
New polymeric acids containing potentially hydrolyzable bonds (1991)

A new family of polymeric acids containing, besides carboxylic groups, biodegradable functions in their main chain have been prepared by Michael-type polyaddition of bis(thiols) to 2,2-bis(acrylamido)-acetic acid. The ability of the same polymers to enter into coupling reactions with model compounds, as well as the possibility of using them as macromonomers, has been verified. © 1991, American Chemical Society. All rights reserved.
Studies on perchlorate complexes of copper(II) and silver(I) with substituted benzimidazoles (1992)

CuL2(ClO4)​2 [L = 2-​(2'-​quinolyl)​benzimidazole (2-​QylBzIH)​, 2,​2'-​bis(benzimidazolyl) sulfide (bBzIH2s)​, 2,​2'-​bis(benzimidazolyl)​ethane (bBzIH2e)​] and AgLClO4 [L = 2,​6-​bis(2-​benzimidazolyl)​pyridine, 2-​QylBzIH, bBzIH2s and bBzIH2e] were prepd. and characterized by cond., magnetic susceptibility, electronic, IR and proton NMR spectra. IR spectra give evidence for coordination of perchlorate in most of these complexes.
How to cope with your sulfur problems. [COPE process; use of oxygen enriched air to increase capacity] (1986)

COPE (Claus Oxygen-based Process Expansion) technology presents an improvement to the modified Claus process that replaces air with up to 100% oxygen to debottleneck Claus Sulphur Recovery Unit's (SRU's). The major equipment requirements of the COPE process are the installation of an acid gas recycle blower and a proprietary burner. The recycle stream acts as a coolant to moderate reaction furnace temperature, effectively replacing nitrogen as a diluent. The specially designed burner allows for the safe and effective handling of the four feed streams: air, oxygen, acid gas, and recycle gas. Co-licensed by Goar, Arrington and Associates, Inc. (GAA) and Air Products and Chemicals, Inc., the COPE process presents an economically attractive means of expanding the capacity of an SRU. The first two COPE units are in commercial operation at a major gulf Coast refinery in the USA and have demonstrated an 85% increase in capacity by enriching to the 55% O/sub 2/ level.
Performance of exhaustive matching algorithms for input-queued switches (2003)

Abstract-- Virtual output queue (VOQ) architecture is commonly used for avoiding head-of-line blocking in input-queued switches. Many algorithms have been developed for transferring the cells from the VOQs to the output ports. Traditional iterative algorithms such as iSLIP and DRRM, achieve 100 % throughput under uniform traffic. But under non-uniform traffic, throughput drops significantly. Recently, a new paradigm of exhaustive matching (EM) has been introduced for handling non-uniform traffic while preserving the complexity of traditional iterative algorithms. In EM, a VOQ is served continuously until it becomes empty. Only the input ports that have finished serving a VOQ look for a new match. This strategy produces very good throughput and delay performance in uniform and non-uniform traffic. However under some traffic patterns, there is a starvation problem when a VOQ occupies an output port for an extended period of time. This problem can be eliminated by providing a priority service for a VOQ that has waited an excessively long time. The resulting algorithm, prioritized EM (PEM), eliminates starvation and achieves very high throughput for many traffic patterns.
Silyl Fluoride Electrophiles for the Enantioselective Synthesis of Silylated Pyrrolidine Catalysts (2011)

Chiral silylated pyrrolidine catalysts are obtained in high yield and enantioselectivity by sparteine-mediated lithiation of N-Boc-pyrrolidine and addition to silyl fluoride electrophiles. The activity and enantioselectivity of a new tert-butyldiphenylsilylpyrrolidine catalyst has been demonstrated for various asymmetric Michael reactions at 5 mol % catalyst loading and affords up to 99% ee for asymmetric Michael reactions with aldehydes and nitro-olefins. Acetaldehyde donors proceed with yields up to 77% and enantioselectivities up to 96% ee, avoiding common side reactions that often lower yields. Insight into the mechanism of pyrrolidine-based catalysts is provided by demonstrating ESI mass spectrometry evidence for activation of a nitro acceptor by formation of a hydrogen-bonding adduct with the catalyst amine. Analysis of reaction intermediates using mass spectrometry provides evidence that the pyrrolidine catalyst also plays a role in activating nitro-olefins through hydrogen-bonding.