gebhart/patrepeval huggingface dataset:
Objective Technique for Evaluating Painful Heel Syndrome and Its Treatment (1983)

The biomechanical evaluation of patients with painful heels has received only limited attention although the potential morbidity and disability associated with such an ailment can be severe. An objective analysis of the patient's foot function during gait can produce useful information to assess the underlying pathology. This method can also help to evaluate the efficacy of various existing treatment protocols. The impulse distribution based on foot-floor vertical reaction force and time under the hind-, mid-, and forefoot was determined in 32 normal subjects while walking in their usual street shoes. Variations related to shoe types were noted, with high heeled shoes causing the most significant deviations from normal. The same technique was applied to 13 painful heel syndrome patients. Characteristic deviations from the normal impulse distribution were noted in these patients which provided the basis for differentiating the pathological condition between the patients with painful heel pads and those with plantar fasciitis. The effectiveness of using heel cups as a therapeutic device was also assessed. Although significant gait changes were not associated with the insertion of heel cups, they did seem to shift the foot-floor impulse forward from the heel region, which made them effective in patients afflicted with localized heel pain, but not in those with plantar fasciitis.
Transparent Deployment of Scientific Workflows across Clouds - Kubernetes Approach (2018)

We present an end-to-end solution for automation of scientific workflow deployment and execution on distributed computing infrastructures. The solution integrates de-facto standard and widely adopted tools, including Terraform and Kubernetes, with our HyperFlow workflow management system. In such a solution, infrastructure providers have abstracted away thanks to generic Kubernetes layer. However, we also support other computing infrastructures, both containerized such as Kubernetes or Amazon ECS, and non-containerized, e.g. Amazon Lambda, in a single unified approach. The resulting solution enables execution of hybrid workflows that utilize multiple computing infrastructures and significantly lowers the complexity related to management of repeatable infrastructures for the execution of scientific workflows and conducting scientific workflow research.
Supplementary Data from Targeting Podoplanin for the Treatment of Osteosarcoma (2023)

Supplementary Data from Targeting Podoplanin for the Treatment of Osteosarcoma
Polymères biorésorbables dérivés poly(e-caprolactone) en ingiénerie tissulaire (2004)

Les polyesters aliphatiques, tels que poly(DL-lactide) (PLA) et poly(e-caprolactone) (PCL), sont a l'heure actuelle etudies et developpes pour des applications therapeutiques temporaires dans les domaines de la chirurgie, la pharmacologie et l'ingenierie tissulaire. Dans ce dernier domaine, la PCL est tres attractive en raison de sa bonne biocompatibilite et sa facilite de mise en œuvre. Toutefois son hydrophobie, sa cristallinite elevee et sa degradation tres lente restreignent considerablement ses applications potentielles. Dans la perspective de faire varier les proprietes, notamment augmenter l'hydrophilie et la degradabilite�� de supports a base de PCL pour cultures de cellules, de nouveau copolymeres PEG/PCL/PLA sont prepares en incorporant sur les chaines PCL des segments hydrophiles (PEG) et/ou facilement degradables (PLA). L'ensemble du travail experimentale est presente en quatre chapitres. . .
Colorimetric ultramicro method for the determination of free fatty acids (1965)

Previously described colorimetric ultramicro methods for the determination of serum and tissue fatty acids have been improved in sensitivity and selectivity by extracting cobalt rather than copper soaps by means of a solvent lighter than water instead of chloroform. The complex of Co++ with α-nitroso-Β-naphthol is measured at 500 mμ.
Local positioning services on IEEE 802.11 networks (2007)

This paper deals with localization services in IEEE 802.11 networks. The proposed solution processes the Time Of Arrival (TOA) of location packets sent by any Mobile Terminal, received by the Location Supporting Nodes (LSN) and the Location Support Server (LSS) that compose the location services architecture. A fully compatible IEEE 802.11 Localization Services protocol supporting data exchange related to both TOA measurement and processing is reported. Simulation results show the method efficiency in both IEEE 802.11 PCF and DCF modes. Assessment of the maximum number of MTs for which location services can be provided is also reported. Since high localization accuracy requires large bandwidth, a broadband antenna for LSN and LSS was designed. The related results are reported in the second part of the paper. Antenna was tested by HP 8510 Network analyzer for the s-parameters, and by anechoic chamber for the radiation pattern and polarization purity. The antenna works at 5.0 GHz (centre frequency) in broadband mode and is matched on the wireless operating frequencies with a percentage more than 8% (1:1.5 VSWR).
Automatic Segmentation of the Left Ventricle in Cardiac CT Angiography Using Convolutional Neural Network (2017)

Accurate delineation of the left ventricle (LV) is an important step in evaluation of cardiac function. In this paper, we present an automatic method for segmentation of the LV in cardiac CT angiography (CCTA) scans. Segmentation is performed in two stages. First, a bounding box around the LV is detected using a combination of three convolutional neural networks (CNNs). Subsequently, to obtain the segmentation of the LV, voxel classification is performed within the defined bounding box using a CNN. The study included CCTA scans of sixty patients, fifty scans were used to train the CNNs for the LV localization, five scans were used to train LV segmentation and the remaining five scans were used for testing the method. Automatic segmentation resulted in the average Dice coefficient of 0.85 and mean absolute surface distance of 1.1 mm. The results demonstrate that automatic segmentation of the LV in CCTA scans using voxel classification with convolutional neural networks is feasible.
Online Trajectory Optimization Using Inexact Gradient Feedback for\n Time-Varying Environments (2020)

This paper considers the problem of online trajectory design under\ntime-varying environments. We formulate the general trajectory optimization\nproblem within the framework of time-varying constrained convex optimization\nand proposed a novel version of the online gradient ascent algorithm for such\nproblems. Moreover, the gradient feedback is noisy and allows us to use the\nproposed algorithm for a range of practical applications where it is difficult\nto acquire the true gradient. In contrast to the most available literature, we\npresent the offline sublinear regret of the proposed algorithm up to the path\nlength variations of the optimal offline solution, the cumulative gradient, and\nthe error in the gradient variations. Furthermore, we establish a lower bound\non the offline dynamic regret, which defines the optimality of any trajectory.\n To show the efficacy of the proposed algorithm, we consider two practical\nproblems of interest. First, we consider a device to device (D2D)\ncommunications setting, and the goal is to design a user trajectory while\nmaximizing its connectivity to the internet. The second problem is associated\nwith the online planning of energy-efficient trajectories for unmanned surface\nvehicles (USV) under strong disturbances in ocean environments with both static\nand dynamic goal locations. The detailed simulation results demonstrate the\nsignificance of the proposed algorithm on synthetic and real data sets. Video\non the real-world datasets can be found at\n{https://www.youtube.com/watch?v=FcRqqWtpf\\_0}\n
The visiting lectureship on aboriginal health: an educational initiative at the University of Toronto. (1996)

Many recent reports on Aboriginal issues have identified three major deficits in Canadian universities: a lack of Aboriginal curriculum content, a lack of faculty role models, and low student enrollment. Many health professional schools have responded by recruiting more Aboriginal students and by introducing Native content into their curricula. This paper describes the six-year experience of the annual program of the Visiting Lectureship on Native Health at the University of Toronto as one of the ways to increase the Aboriginal curricular content. The three-week program covers the selected Aboriginal health issue by sequentially exploring its historical background, the extent of the current problem and its future solutions. Over six years, 37 Native speakers delivered 83 lectures, 19 public fora and 98 seminars and workshops to 3 universities and 12 professional and community agencies. Over 7,900 individuals have participated in the program and the response has been very positive.
Mechanism of UV light-induced photorelaxation in isolated rat aorta (2000)

Isolated rat thoracic aorta which is pharmacologically precontracted by phenylephrine induces photorelaxation when exposed to long wave length UV-light. The aim of the present study was to characterize the mechanism of UV-light induced by photorelaxation in the rat aorta. 1. UV light relaxed both endothelium-intact and -denuded rat aortic rings contracted by phenylephrine. The magnitude of relaxation on UV light was dependent on the exposure time and slightly greatly in endothelium-denuded rings than in endothelium-intact preparations. 2. L-NAME (10 nM-100 uM) but not D-NAME completely inhibited the photorelaxation in a concentration dependent manner. 3. The UV-induced relaxation was inhibited by methylene blue (1 -100 uM), and verapamil (100 nM), and removal of extracellular Ca2+. In contrast, UV-light induced photorelaxation was potentiated by N(w)-nitro-Larginine (L-NOARG) treatment. 4. In immunocytochemical analysis of UV-light induced iNOS and eNOS expression in rat aortas, at which expression levels were increased in a time-dependent manner on UV-irradiation in aortic endothelium and smooth muscle, respectively. These results suggest that UV light-induced photorelaxation may be due to nitric oxide from exogenously administered L-arginine as well as endogenous nitric oxide donors such as amino acid and arginine derivatives. Additional suggestion is that UV light stimulates the expression of nitric oxide synthases, and its activity for nitric oxide generation is dependent on cytosolic Ca2+ originated from extracellular space.
Self‐management of immunomodulatory drug treatment in multiple myeloma patients (2020)

The questionnaire has shown to be a valid tool for the assessment of the adherence and side-effect management skills for MM patients with IMID treatment.
Reactivity of cyclosiloxane with 3,3,4,4,5,5,6,6,6‐nonafluorohexyl group and its application to fluorosilicone synthesis (2001)

The reactivity of cyclosiloxane with 3,3,4,4,5,5,6,6,6-nonafluorohexyl group and its application to fluorosilicone synthesis were studied. In contrast to the polymerization of the commercially available 1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane (CF3–D3), the polymerization of 1,3,5-tris(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-1,3,5-trimethylcyclotrisiloxane (C4F9–D3) with sodium hydroxide yielded 1,3,5,7-tetrakis(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-1,3,5,7-tetramethylcyclotetrasiloxane {[C4F9CH2CH2(CH3)SiO]4 (C4F9–D4)} as the major product, which was the result of the depolymerization by a backbiting mechanism. On the other hand, the polymerization of C4F9–D3 with trifluoromethanesulfonic acid yielded a polymer with good reproducibility, although the distribution of molecular weight tended to be bimodal. C4F9–D3 was also successfully copolymerized with octamethylcyclotetrasiloxane (D4). The properties of the obtained copolymers changed almost linearly with the amount of [C4F9C2H4(CH3)SiO] units, except for the surface tension. The surface tension of the copolymer containing more than 50% [C4F9C2H4(CH3)SiO] units by weight was almost as low as that of the homopolymer. When the copolymer containing 50% [C4F9C2H4(CH3)SiO] units by weight was examined for an antifoaming agent, it worked as effectively as the homopolymer in the toluene foaming system. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 3333–3340, 2001
Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage (2016)

Mouse fetal intestinal progenitors lining the epithelium prior to villogenesis grow as spheroids when cultured ex vivo and express the transmembrane glycoprotein Trop2 as a marker. Here, we report the characterization of Trop2-expressing cells from fetal pre-glandular stomach, growing as immortal undifferentiated spheroids, and their relationship with gastric development and regeneration. Trop2(+) cells generating gastric spheroids differed from adult glandular Lgr5(+) stem cells, but appeared highly related to fetal intestinal spheroids. Although they shared a common spheroid signature, intestinal and gastric fetal spheroid-generating cells expressed organ-specific transcription factors and were committed to intestinal and glandular gastric differentiation, respectively. Trop2 expression was transient during glandular stomach development, being lost at the onset of gland formation, whereas it persisted in the squamous forestomach. Undetectable under homeostasis, Trop2 was strongly re-expressed in glands after acute Lgr5(+) stem cell ablation or following indomethacin-induced injury. These highly proliferative reactive adult Trop2(+) cells exhibited a transcriptome displaying similarity with that of gastric embryonic Trop2(+) cells, suggesting that epithelium regeneration in adult stomach glands involves the partial re-expression of a fetal genetic program.
High‐frequency Integrated Microelectromechanical Resonators and Filters (2004)

This chapter contains sections titled: Introduction Microelectromechanical Resonators Fabrication Technologies Filter Implementations Dissipation Mechanisms Acknowledgments References
Design and Control of a Dexterous Biomimetic Multi-Limbed Walking Robot (July 2005) (2005)

� Abstract— This paper introduces a multi-limbed walking robot, capable of vertical climbing, named RIDES (Remote Infrastructure Delivery & Entry System). An overview of the mechanical, electrical, and control architecture will be presented along with the current results. The primary mission of the robot is aimed at search and rescue operations in urban/industrial environments. It is anticipated that a large degree of dexterity is required to tackle complex indoor and outdoor terrains as well as decaying urban/industrial settings. As such, a novel mechanism and controller have been designed to address this need.
Efficient and Selective Telomerization of 1,3‐Butadiene with Diols Catalyzed by Palladium–Carbene Complexes (2008)

The selective telomerization of 1,3-butadiene with seven different linear and cyclic diols proceeds in the presence of in situ generated palladium carbene catalysts. By applying optimized reaction conditions, including very low metal loadings (2-10 ppm), excellent catalyst turnover numbers (>250,000) and good chemoselectivities are observed with respect to the mono-octadienyl ether derivatives. This protocol allows the efficient preparation of unsaturated alcohols, which are useful for various applications.
Supplementary Figure 1 from DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory (2023)

&lt;p&gt;PDF file - 62K&lt;/p&gt;
Scale-up of electrospray atomization using linear arrays of Taylor cones (1993)

Linear arrays of Taylor cones were established on capillary electrode tubes opposite a slotted flat plate counterelectrode to investigate the feasibility of increasing the liquid throughput rate in electrospray atomizers. It was found that individual Taylor cones could be established on each capillary over a wide range of the capillary radius to spacing ratio R/S. The onset potential Vs required to establish the cones varied directly with R/S, but the liquid flow rate per cone and current per cone were nearly independent of R/S for a given overpotential ratio P=V/Vs. Only six working capillaries were used, but the results per cone are applicable to larger arrays of cones since end effects were minimized.
Serine 19 phosphorylation and 14‐3‐3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40 (2019)

Multisite phosphorylation and structural flexibility allow for complex regulation of proteins through cellular signaling. Tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, is regulated by multiple neuronal signaling pathways through phosphorylation at serine 19 (Ser19), serine 31 (Ser31), and serine 40 (Ser40) located in the flexible, far N-terminal region of the regulatory domain. Phosphorylated Ser19 (pSer19) provides a binding site for 14-3-3 proteins, a family of multi-target binding adaptor proteins. We hypothesized that pSer19 and 14-3-3 binding can regulate access to the Ser31 and Ser40 sites and modulate the dynamics of their phosphorylation state. To avoid complications from upstream signal interactions and have good control of TH-phosphorylation and 14-3-3 binding stoichiometry, we used purified recombinant human TH and 14-3-3 dimer types. We found that pSer19 strongly stimulated Ser31 phosphorylation (4.6-fold), but inhibited pSer31 dephosphorylation (3.4-fold). Binding of 14-3-3ζ counteracted the stimulatory effect of pSer19 on phosphorylation at Ser31, but amplified the effect on its dephosphorylation. In contrast, phosphorylation at Ser19 had moderate effect on pSer40 dephosphorylation, but 14-3-3ζ binding inhibited dephosphorylation, an effect that was consistent across different homo- and heterodimeric 14-3-3s. Additional phosphorylation of Ser31 or Ser40 had little impact on the binding affinity of pSer19 TH to 14-3-3s. Mathematical modeling was performed to elucidate possible physiological implications of these observations. We propose a role of Ser19 and 14-3-3 proteins as modulators of TH phosphorylation in response to neuronal co-signaling events. These mechanisms add to our understanding of the multifaceted roles of phosphorylation and adaptor proteins in cellular signaling.
ChemInform Abstract: O‐(N‐ACYLAMINOACYL)‐2‐PYRIDYLMETHYLKETOXIMES AND THEIR USE IN PEPTIDE SYNTHESIS (1982)

Abstract Unter Verwendung der Aktivestergruppierung Pmo [ d.h. von Titelverbindungen wie (I) bzw. (V)] werden Leu‐enkephalin (VIb) [durch Deblockierung von (VIa)], Met‐enkephalin (VII) und das (VIb)‐Analoge (VIII) [jeweils analoger Aufbau] in Ausb. von 55%, 35% bzw. 38%, bezogen auf die jeweilige C‐terminale Ausgangsverbindung, synthetisiert.
Effect of wall suction on the stability of compressible subsonic flows over smooth two-dimensional backward-facing steps (1989)

The effect of suction on the stability of compressible flows over backward-facing steps is investigated. Mach numbers up to 0.8 are considered. The results show that continuous suction stabilizes the flow outside the separation bubble, but it destabilizes the flow inside it. Nevertheless, the overall N factor decreases as the suction level increases due to the considerable reduction of the separation bubble. For the same suction flow rate, properly distributed suction strips stabilize the flow more than continuous suction. The size of the separation bubble, and hence its effect on the instability can be considerably reduced by placing strips with high suction velocities in the separation region.
Solubility of Fluorinated Pharmaceuticals in Dense Carbon Dioxide (2000)

The solubilities of benzoic acid and fluorinated benzoic acid derivatives in dense carbon dioxide were measured at 35 and 55 °C to find out how much fluorination increases the solubility of organic pharmaceuticals in dense carbon dioxide. The solubilities of two higher molecular weight pharmaceuticals, triflupromazine and flufenamic acid, in dense carbon dioxide were also measured. The solubility of benzoic acid is approximately 0.2 wt % at 35 °C and 100 bar. Attaching one fluorine atom increased the solubility of benzoic acid slightly, and the solubility of 3-fluorobenzoic acid was approximately 1 wt %. The solubility of 3,4-difluorobenzoic acid was 1.3 wt % at 35 °C and 103 bar. Introduction of a trifluoromethyl group increased the solubility significantly, and the solubility of 3-(trifluoromethyl)benzoic acid in dense carbon dioxide at 35 °C and 100 bar was approximately 7 wt %, which is almost 40 times higher than the solubility of benzoic acid in the same conditions. The solubility of triflupromazine was relatively high, i.e., 4.4 wt % at 43 °C and 145 bar. Flufenamic acid was very sparingly soluble at ambient temperatures (<50 °C), and 70−80 °C was necessary to reach 1−3 wt % solubility. These experiments show that dense carbon dioxide is a feasible solvent for fluorinated pharmaceuticals and that the fluorine content of a compound can be used as a clue to find carbon dioxide soluble molecules.
Precipitation Behavior of V-Enrichment Mineral in Steelmaking Slag Bearing Vanadium Modified by SiO<sub>2</sub> (2013)

In order to concentrate vanadium in converter slag bearing vanadium, the effect of SiO2 on behavior of vanadium in the process of enriching was studied. Experimental results show that, during cooling, dicalcium silicate containing vanadium and phosphorus precipitate first from original slag. For original with 7% SiO2, most of vanadium dissolves in calcium silicate phase. However, the proportion of dicalcium silicate is big. For slag modified by 12% SiO2, during cooling, two vanadium-rich minerals precipitate firstly, i.e. Ca3(V,P)2O8(30-33%V2O5) and Ca3(V,P)2O8•nCa2SiO4 (14-31%V2O5), then 3CaO•2SiO2 (2-4%V2O5) generates. With addition amount of SiO2 increasing, the proportion of 3CaO•2SiO2 decreases gradually, and the content of vanadium in vanadium-rich phase increases gradually. So appropriate SiO2 addition can suppress the precipitation of Ca2SiO4 and Ca3•Si2O7, and promote the generation of vanadium-rich phase.
SIX®: A New Resin Treatment Technology for Drinking Water (2009)

The history of ion exchange is marked by many important milestones, notably the development of novel polymeric materials and considerable advances in our understanding of the underlying fundamental principles. Separately, there have been major advances in the design and development of the apparatus and equipment required to perform industrial ion exchange and also for large scale applications in the production of drinking water, like the MIEX® process from Orica. This paper reviews the progress that has been made during the last three years within the research facilities of PWN which have resulted in a new ion exchange process for the direct treatment of water containing high amounts of suspended matter such as surface waters. This new process has been called SIX® and will most likely be operational at a flow of 4000 m3/h by 2012.
The travel patterns and travel distance of tourists to national parks in China (1999)

This is a case study with data from Jiuzhaigou and other national parks in China. It was revealed that the travel distance of tourists to a destination is related to their demographic data such as age, occupation, education level, actual income, self‐perceived income level, landscape preference and tourist attitude; but not related to the tourist motivation. Perceived distance has the character of distance decay, and substitute distance is supposed to be related to travel distance. “Pareto Model” was proved to be the best‐fit model of Taylor's five types of distance decay model. Also, in this paper, the distance characteristics and uneven spatial structure of convergent travel behavior of tourists and related market background were studied by using different distance cumulative curves.