gebhart/patrepeval huggingface dataset:
DNA uptake sequences in Helicobacter pylori (2000)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Exxon catalytic coal-gasification process development program. Quarterly technical progress report, October-December 1979 (1980)

Work continued on the catalyst recovery screening studies to evaluate the economic impacts of alternative processing approaches and solid-liquid separation techniques. Equipment specifications have been completed for two cases with countercurrent water washing using rotary-drum filters for the solid-liquid separations. Material and energy balances have been completed for an alternative methane recovery process configuration using low pressure stripping which requires 26% less horsepower than the Study Design system. A study has been initiated to identify trace components which might be present in the CCG gas loop and to assess their potential impacts on the CCG process. This information will be used to assist in planning an appropriate series of analyses for the PDU gasifier effluent. A study has been initiated to evaluate the use of a small conventional steam reformer operating in parallel with a preheat furnace for heat input to the catalytic gasifier which avoids the potential problem of carbon laydown. Preliminary replies from ten manufacturers are being evaluated as part of a study to determine the types and performance of coal crushing equipment appropriate for commercial CCG plants. A material and energy balance computer model for the CCG reactor system has been completed. The new model will provide accurate, consistent and cost-efficient material and energy balances for the extensive laboratory guidance and process definition studies planned under the current program. Other activities are described briefly.
Preparation of Pseudo‐Peptide Building Blocks with retro‐Thioamide Bond Mediated via Thiocarbamoyl Meldrum's Acid (2012)

Abstract An easy and efficient synthesis of pseudo‐tripeptide containing a thiomalonamide moiety was developed. Isothiocyanate derivatives of amino acids react smoothly with 2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione ( Meldrum 's acid) to yield new thiocarbamoyl derivatives of Meldrum 's acids. Thermal decomposition of these new derivatives leads to thiocarbamoyl ketenes, which acylate amino acid esters to give pseudo‐tripeptides.
Effect of Phosphorus Deposit Modifiers on Gasoline Octane Quality. (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of Phosphorus Deposit Modifiers on Gasoline Octane Quality.F. C. Gunderloy Jr. and R. F. NeblettCite this: J. Chem. Eng. Data 1962, 7, 1, 142–145Publication Date (Print):January 1, 1962Publication History Published online1 May 2002Published inissue 1 January 1962https://pubs.acs.org/doi/10.1021/je60012a041https://doi.org/10.1021/je60012a041research-articleACS PublicationsRequest reuse permissionsArticle Views47Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Catalytic epoxidation of cyclohexene using Molybdenum complexes (2004)

Three oxomolybdenum complexes, MoO2(acac)2, MoO2(oxine)2 and MoO2(PDTC)2, were prepared, characterised and essayed as catalysts for the epoxidation of cyclohexene in a batch reactor. The reaction was performed at 60 and 70°C using tert-butylhydroperoxide as oxidant agent and toluene and dichloroethane as solvents. All the complexes exhibit high selectivity to the corresponding epoxide under the studied conditions, being the MoO2(acac)2 the one that exhibits the highest specific rate constant. An enhancement in the specific rate constant is observed at higher reaction temperatures and by using dichloroethane as solvent. A detailed kinetic study showed that the cyclohexene epoxidation is a global second order reaction: order one with respect to cyclohexene and also order one dependence in tert-butylhydroperoxide. A reaction mechanism that explains the experimental results is proposed
Non-destructive permittivity measurement of solid materials (2000)

An open-coaxial probe suitable for measuring the permittivity of solid materials has been designed and tested. The peculiar structure of the probe allows an easy and firm contact with the surface of the material under measurement, resulting in highly reliable and reproducible dielectric measurements. The permittivity measurement is absolute, as the calibration procedure - based on a genetic algorithm - does not require the use of dielectric standards. The measurement system - including the probe, a network analyser, and the numerical code to determine the permittivity from reflection measurements - have been tested on solid materials of known properties, and used for determining the dielectric characteristics of several types of wood.
Examination for realization of a high precision crystal sensor (2008)

the frequency stability of a crystal sensor in liquid is influenced by a decrease in Q value. Also, the frequency stability is influenced by the water pressure, liquid temperature, and etc. this paper shows a new method of realizing a highly precise crystal sensor by using two crystal sensors for the purpose of solving the abovementioned problem. In conclusion, it has been verified that a crystal resonator having two pairs of electrodes on one AT-cut crystal blank can be used for sensors in liquid for various applications.
Figure S6 from Low-pass Whole-genome Sequencing of Circulating Cell-free DNA Demonstrates Dynamic Changes in Genomic Copy Number in a Squamous Lung Cancer Clinical Cohort (2023)

&lt;p&gt;Survival and demographic analysis with cfDNA tumor fraction.&lt;/p&gt;
Supplementary Table 1 from Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer (2023)

&lt;p&gt;PDF file - 55KB, Pharmacokinetic properties of LFA102 in rodents&lt;/p&gt;
Direct Inhibition of MmpL3 by Novel Antitubercular Compounds (2019)

MmpL3, an essential transporter involved in the export of mycolic acids, is the proposed target of a number of antimycobacterial inhibitors under development. Whether MmpL3 serves as the direct target of these compounds, however, has been called into question after the discovery that some of them dissipated the proton motive force from which MmpL transporters derive their energy. Using a combination of in vitro and whole-cell-based approaches, we here provide evidence that five structurally distinct MmpL3 inhibitor series, three of which impact proton motive force in Mycobacterium tuberculosis, directly interact with MmpL3. Medium- to high-throughput assays based on these approaches were developed to facilitate the future screening and optimization of MmpL3 inhibitors. The promiscuity of MmpL3 as a drug target and the mechanisms through which missense mutations located in a transmembrane region of this transporter may confer cross-resistance to a variety of chemical scaffolds are discussed in light of the exquisite vulnerability of MmpL3, its apparent mechanisms of interaction with inhibitors, and evidence of conformational changes induced both by the inhibitors and one of the most commonly identified resistance mutations in MmpL3.
A primer on stem cell research. (2007)

Stem cell research holds promise for new treatments for diseases such as Parkinson's and injuries such as those to the spinal cord. Yet stem cell research remains steeped in controversy. This article defines key terms and outlines some of the basic concepts related to stem cell research in order to clarify concepts and correct misconceptions. It also briefly discusses what scientists, particularly those at the University of Minnesota, are learning about adult and embryonic stem cells and their potential for research and treatment.
Epitaxial Growth of YBaCuO Films on Sapphire at 500°C by Metalorganie Chemical Vapor Deposition (1989)

Single crystalline films of YBaCuO have been epitaxially prepared for the first time on sapphire substrates at temperatures as low as 500°C by the metalorganic chemical vapor deposition method. The starting materials were Y(HFA) 3 , Ba(HFA) 2 , and Cu(AcAc) 2 . Deposition was carried out with an oxygen pressure of 10 Torr. Electron probe measurements and Auger electron spectroscopy suggest that the constituent of the film is YBa 2 Cu 3 O x . Carbon has not been detected in the film. Spots and streak patterns obtained in the electron diffraction measurements suggest high crystalline quality and smoothness of the surface.
Configuration-Aware Change Impact Analysis (T) (2015)

Understanding variability is essential to allow the configuration of software systems to diverse requirements. Variability-aware program analysis techniques have been proposed for analyzing the space of program variants. Such techniques are highly beneficial, e.g., to determine the potential impact of changes during maintenance. This paper presents an interprocedural and configuration-aware change impact analysis (CIA) approach for determining possibly impacted products when changing source code of a product family. The approach further supports engineers, who are adapting specific product variants after an initial pre-configuration. The approach can be adapted to work with different variability mechanism, it provides more precise results than existing CIA approaches, and it can be implemented using standard control flow and data flow analysis. Using an industrial product line we report evaluation results on the benefit and performance of the approach.
Efficient Reconstruction of Two-Periodic Nonuniformly Sampled Signals Applicable to Time-Interleaved ADCs (2006)

Nonuniform sampling occurs in many practical applications either intentionally or unintentionally. This thesis deals with the reconstruction of two-periodic nonuniform signals which is of great importance in two-channel time-interleaved analog-to-digital converters. In a two-channel time-interleaved ADC, aperture delay mismatch between the channels gives rise to a two-periodic nonuniform sampling pattern, resulting in distortion and severely affecting the linearity of the converter. The problem is solved by digitally recovering a uniformly sampled sequence from a two-periodic nonuniformly sampled set. For this purpose, a time-varying FIR filter is employed. If the sampling pattern is known and fixed, this filter can be designed in an optimal way using least-squares or minimax design. When the sampling pattern changes now and then as during the normal operation of time-interleaved ADC, these filters have to be redesigned. This has implications on the implementation cost as general on-line design is cumbersome. To overcome this problem, a novel time-varying FIR filter with polynomial impulse response is developed and characterized in this thesis. The main advantage with these filters is that on-line design is no longer needed. It now suffices to perform only one design before implementation and in the implementation it is enough to adjust only one variable parameter when the sampling pattern changes. Thus the high implementation cost is decreased substantially. Filter design and the associated performance metrics have been validated using MATLAB. The design space has been explored to limits imposed by machine precision on matrix inversions. Studies related to finite wordlength effects in practical filter realisations have also been carried out. These formulations can also be extended to the general M - periodic nonuniform sampling case.
DenseAlert: Incremental Dense-Subtensor Detection in Tensor Streams (2017)

Consider a stream of retweet events - how can we spot fraudulent lock-step behavior in such multi-aspect data (i.e., tensors) evolving over time? Can we detect it in real time, with an accuracy guarantee? Past studies have shown that dense subtensors tend to indicate anomalous or even fraudulent behavior in many tensor data, including social media, Wikipedia, and TCP dumps. Thus, several algorithms have been proposed for detecting dense subtensors rapidly and accurately. However, existing algorithms assume that tensors are static, while many real-world tensors, including those mentioned above, evolve over time. We propose DenseStream, an incremental algorithm that maintains and updates a dense subtensor in a tensor stream (i.e., a sequence of changes in a tensor), and DenseAlert, an incremental algorithm spotting the sudden appearances of dense subtensors. Our algorithms are: (1) Fast and 'any time': updates by our algorithms are up to a million times faster than the fastest batch algorithms, (2) Provably accurate: our algorithms guarantee a lower bound on the density of the subtensor they maintain, and (3) Effective: our DenseAlert successfully spots anomalies in real-world tensors, especially those overlooked by existing algorithms.
Concluding remarks on the Lasker/IRRF initiative on amblyopia (2018)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Chlorine incorporation into silica lightguide materials (2002)

Summary form only given. For many years it has been well known that high-purity synthetic silica glasses and fibers contain relatively large amounts of chlorine (some hundreds or thousands) in consequence of the preparation and drying process via gaseous chlorine compounds. Chlorine in silica may influence the refractive index, thermal properties, radiation-induced loss, drawing-induced, and other defects. Up to now, however, the process of chlorine interaction and incorporation is scarcely understood. We study this process.
Reno- and cardioprotective molecular mechanisms of SGLT2 inhibitors beyond glycemic control: from bedside to bench (2023)

Large placebo-controlled clinical trials have shown that sodium-glucose cotransporter-2 inhibitors (SGLT2i) delay the deterioration of renal function and reduce cardiovascular events in a glucose-independent manner, thereby ultimately reducing mortality in patients with chronic kidney disease (CKD) and/or heart failure. These existing clinical data stimulated preclinical studies aiming to understand the observed clinical effects. In animal models, it was shown that the beneficial effect of SGLT2i on the tubuloglomerular feedback (TGF) improves glomerular pressure and reduces tubular workload by improving renal hemodynamics, which appears to be dependent on salt intake. High salt intake might blunt the SGLT2i effects on the TGF. Beyond the salt-dependent effects of SGLT2i on renal hemodynamics, SGLT2i inhibited several key aspects of macrophage-mediated renal inflammation and fibrosis, including inhibiting the differentiation of monocytes to macrophages, promoting the polarization of macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype, and suppressing the activation of inflammasomes and major proinflammatory factors. As macrophages are also important cells mediating atherosclerosis and myocardial remodeling after injury, the inhibitory effects of SGLT2i on macrophage differentiation and inflammatory responses may also play a role in stabilizing atherosclerotic plaques and ameliorating myocardial inflammation and fibrosis. Recent studies suggest that SGLT2i may also act directly on the Na<sup>+</sup>/H<sup>+</sup> exchanger and Late-I<sub>Na</sub> in cardiomyocytes thus reducing Na<sup>+</sup> and Ca<sup>2+</sup> overload-mediated myocardial damage. In addition, the renal-cardioprotective mechanisms of SGLT2i include systemic effects on the sympathetic nervous system, blood volume, salt excretion, and energy metabolism.
Atomic Origins of Monoclinic-Tetragonal (Rutile) Phase Transition in Doped VO2 Nanowires (2015)

There has been long-standing interest in tuning the metal-insulator phase transition in vanadium dioxide (VO2) via the addition of chemical dopants. However, the underlying mechanisms by which doping elements regulate the phase transition in VO2 are poorly understood. Taking advantage of aberration-corrected scanning transmission electron microscopy, we reveal the atomistic origins by which tungsten (W) dopants influence the phase transition in single crystalline WxV1-xO2 nanowires. Our atomically resolved strain maps clearly show the localized strain normal to the (122̅) lattice planes of the low W-doped monoclinic structure (insulator). These strain maps demonstrate how anisotropic localized stress created by dopants in the monoclinic structure accelerates the phase transition and lead to relaxation of structure in tetragonal form. In contrast, the strain distribution in the high W-doped VO2 structure is relatively uniform as a result of transition to tetragonal (metallic) phase. The directional strain gradients are furthermore corroborated by density functional theory calculations that show the energetic consequences of distortions to the local structure. These findings pave the roadmap for lattice-stress engineering of the MIT behavior in strongly correlated materials for specific applications such as ultrafast electronic switches and electro-optical sensors.
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells (2014)

It has been previously demonstrated that genistein exhibits anticancer activity against breast cancer. However, the precise mechanisms underlying the anticancer effect of genistein, in particular the epigenetic basis, remain unclear. In this study, we investigated whether genistein could modulate the DNA methylation status and expression of cancer-related genes in breast cancer cells. We treated MCF-7 and MDA-MB-231 human breast cancer cells with genistein in vitro. We found that genistein decreased the levels of global DNA methylation, DNA methyltransferase (DNMT) activity and expression of DNMT1. Yet, the expression of DNMT3A and DNMT3B showed no significant change. Using molecular modeling, we observed that genistein might directly interact with the catalytic domain of DNMT1, thus competitively inhibiting the binding of hemimethylated DNA to the catalytic domain of DNMT1. Furthermore, genistein decreased DNA methylation in the promoter region of multiple tumor suppressor genes (TSGs) such as ataxia telangiectasia mutated (ATM), adenomatous polyposis coli (APC), phosphatase and tensin homolog (PTEN), mammary serpin peptidase inhibitor (SERPINB5), and increased the mRNA expression of these genes. However, we detected no significant changes in the DNA methylation status or mRNA expression of stratifin (SFN). These results suggest that the anticancer effect of genistein on breast cancer may be partly due to its ability to demethylate and reactivate methylation-silenced TSGs through direct interaction with the DNMT1 catalytic domain and inhibition of DNMT1 expression.
Abstract C033: Racial differences in the associations between luminal master regulator transcription factor expression and breast cancer survival (2020)

Abstract Purpose: Women of African ancestry in the United States are more likely to die from breast cancer than their European counterparts. While prior studies suggest differences in the frequency of hormone receptor-negative disease as an underlying cause, recent studies report higher race-based mortality rates in patients with hormone receptor-positive, luminal breast cancer. Here we explore biologic factors that may underly this disparity by comparing racial differences in the level, functional activity, and prognostic significance of 3 master transcriptional regulators of mammary luminal differentiation. Patients and Methods: Medical records and tissues from 555 patients (293 European and 262 African ancestry) diagnosed with Stage 0 to IV breast cancer, from 2001 to 2010 at a major medical center in East North Carolina, were analyzed for the expression of functional biomarkers of luminal differentiation including estrogen receptor (ESR1), and pioneer transcription factors FOXA1 and GATA3. Differential comparison of protein expression was integrated with network-level gene expression analysis (22% of cohort) to define predictive correlations with race and survival. Results: Univariate and multivariate odds ratios combined with area under the curve receiver operator characteristics show significant differences in predictive activity of these functional biomarkers based on race and survival—ESR1 (EA OR= 0.47, p = 5e-04; AA OR= 0.77, p = 0.22), FOXA1 (EA OR= 0.38, p= 1.4e-04; AA OR = 0.53, p = 1.3e-02), and GATA3 (EA OR= 0.36, p= 3.7e-06, AA OR= 0.57, p= 0.51)—and uncover genes in the downstream regulons of these biomarkers that strongly correlate either with genetic ancestry or overall survival. Conclusion: Transcriptional regulatory networks linked to mammary luminal differentiation reveal race-specific differences in master regulatory activity that may underlie tumor characteristics contributing to racial disparities in outcome. These biomarkers and their downstream regulons represent important targets to explore intrinsic mechanisms that drive breast cancer survival disparities. Citation Format: Jung S. Byun, Sandeep K. Singhal, Sam Park, Dae Ik Yi, Tingfen Yan, Ambar Caban, Alana Jones, Partha Mukhopadhyay, Sara Gil Hernandez, Stephen Hewitt, Lisa A. Newman, Melissa Davis, Jorge Sepulveda, Adrianna De Siervi, Anna Napoles, Nasreen Vohra, Kevin Gardner. Racial differences in the associations between luminal master regulator transcription factor expression and breast cancer survival [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr C033.
Distinction between horizontal and vertical plasmonic modes in 3D nanostructures (2014)

International audience