gebhart/patrepeval huggingface dataset:
Minutes of the Business Meeting of the American Pancreatic Association, Friday, November 5, 2021, Miami Beach, Florida (2022)

Hines, O. Joe MD; President; Habtezion, Aida MD, MSc; President-Elect; Rustgi, Anil K. MD; Past President; Saluja, Ashok K. PhD; Secretary-Treasurer; Li, Min PhD; Councilor; Uc, Aliye MD; Councilor; Bellin, Melena D. MD; Councilor; Go, Vay Liang W. MD; Editor-in-Chief, Pancreas
Activation of Classical and Alternative Nuclear Factor-kappaB (NF-kB) Pathways in Diffuse Large B-Cell Lymphomas. (2004)

Abstract Activation of the NF-kB pathway is involved in many human neoplasms. In this study we examined the status of the NF-kB canonical (IkB, p50/p65) and non-canonical (p52, RelB) pathways in diffuse large B-cell lymphomas (DLBCL), which are a common and heterogeneous group of lymphoid malignancies. DLBCL have been divided into activated B-cell (ABC) like, and germinal center B-cell (GCB) like subgroups, which have been reported to have high and low NF-kB activity, respectively. However, the nature of the NF-kB complexes in this lymphoma entity has not been previously evaluated. Therefore we performed Western blotting, electrophoretic mobility shift assays (EMSA) and real time quantitative RT-PCRs on nuclear and cytoplasmic protein and total RNA extracts in 20 primary tumor samples and 9 different DLBCL cell lines. In the cell lines, presence of NF-kB proteins in nuclear extracts correlated with expression of NF-kB target genes (CCR7, IkBa, CCND2, BCL-2, IRF4) as determined by RT-PCR. Therefore, these could be assigned into GCB and ABC-like categories. In primary DLBCLs, EMSA showed NF-kB binding in all but one case. The same cases (19/20) had high p52 in the nucleus indicating activation of the alternative pathway. TNF family ligand BAFF was also found to be expressed in all primary samples and most cell lines. The classical pathway, as determined by nuclear p50, was also present in these cases. Levels of p65 and RelB expression were variable, but did not correlate with the mRNA expression of NF-kB target genes. In conclusion, while DLBCL cell lines may be divided into two distinct categories, the primary samples represented a spectrum of NF-kB target gene activity, while levels of NF-kB expression were high. BAFF expression and activation of the alternative pathway may be important in the pathogenesis of DLBCL.
Overcoming cancer therapy resistance by targeting inhibitors of apoptosis proteins and nuclear factor-kappa B. (2009)

Chemo- or radioresistance markedly impairs the efficacy of cancer therapy and involves anti-apoptotic signal transduction pathways that prevent cell death. In resistant cancer cells, both inhibitors of apoptosis proteins (IAPs) and nuclear factor-kappa B (NF-kappaB) play a pivotal role in preventing apoptosis triggered by a variety of stresses, facilitating them as potential targets in cancer treatment. Furthermore, mounting evidences have established the crosstalks between IAPs (eg. XIAP, cIAP-1, cIAP-2) and proteins involved in NF-kappaB signaling (eg. TRAF2, RIP1, TAB1). Second mitochondria-derived activator of caspases (Smac) is a mitochondrial protein that released into cytoplasm upon apoptotic stimuli. As Smac functions as an endogenous IAP inhibitor, small molecule Smac-mimetics are believed to neutralize IAPs function that results in liberating caspase activity and promoting apoptosis. Moreover, recent studies show that Smac-mimetics may kill cancer cells in a different manner, which involves inducing ubiquitination of cIAPs, regulating NF-kappaB signaling and facilitating TNFalpha-triggered, caspase-8-mediated apoptosis in a certain cancer cell types. In other cancer cells that are resistant to TNFalpha or chemo/radiotherapy, Smac-mimetic IAP-inhibitors can enhance ionizing radiation or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, indicating the potential role of Smac-mimetics in overcoming acquired therapy-resistance. Such findings provide important impetus for utilizing IAP-inhibitors as novel adjuvant therapy for the TNFalpha-resistant, NF-kappaB constitutively active cancers that account for the majority of patients who are refractory to current therapeutic approaches.
Assessment of Aβ deposition in mild cognitive impairment with 18F-Florbetaben (2010)

438 Objectives Amyloid deposition precedes cognitive decline as shown in 11C-PiB PET studies. PiB use is currently limited to settings with an on-site cyclotron, so 18F’s longer half-life makes a 18F labeled amyloid tracer better suited for clinical practice where regional synthesis and distribution is possible. To determine 18F-Florbetaben retention in MCI patients compared to healthy controls (HC) and AD patients. Methods 26 HC subjects (MMSE 29 ± 1), 43 MCI subjects (MMSE 27± 2) and 26 subjects with mild to moderate AD (MMSE 23±3) underwent 18F-Florbetaben PET studies. Aβ burden was assessed using Standardized Uptake Value normalized to cerebellar cortex (SUVR) at 90-110 minutes post injection. Cognitive scores were correlated to the PET results. Results Tracer retention was significantly higher in ADs than HCs (neocortical SUVR 1.95±0.3 vs 1.28±0.2, respectively). About 50% of the MCIs presented an “AD-like” pattern of cortical retention, whilst the rest resemble a “HC-like” retention pattern. The average neocortical SUVR for the group was 1.46±0.4. Neocortical SUVR correlated with composite episodic memory score (r=-0.53, p=0.0003) and MMSE (r=-0.4, p=0.008) in MCI, but not in HC or AD. Conclusions 18F-Florbetaben PET appears valuable in assessing AD neuropathology in vivo, with similar findings as 11C-PiB PET studies. Follow-up studies on these MCI subjects will help determine the usefulness of 18F-Florbetaben PET in predicting progression to AD. Research Support Supported in part by Bayer Schering Pharma
Properties of arylpolyesters with reference to water content (1995)

Abstract The 4000–2000 cm −1 infrared spectral region from transmission FTIR spectra of films (≈ 220 μm thick) of amorphous poly (ethylene terephthalate) (PET) and poly(ethylene 2, 6‐naphthalenedicarboxylate) (PEN) was analyzed. In addition to the strong bands for the stretching vibration modes of H‐C bonds, the ester‐overtone band at about 3430 cm −1 and a doublet (3630, 3550 cm −1 ) band, related to absorbed water, appear. The spectra for these materials show significant differences in absorptivity and frequency for the ester overtone band. Real time water sorption/desorption in these films was investigated simultaneously by FTIR spectroscopy and by measurement of weight changes. A linear correlation between the integrated absorbance of the water bands and the relative weight variation of the films was found for these two polymers. Results show that the infrared absorptivity of these bands is identical in both materials and that water molecules are weakly bound to ester groups throughout the films. However, it turns out that the water content is higher in the case of PEN which has a larger specific volume.
Low power decoding of BCH codes (2004)

Low power decoding of error control codes is desirable not only for hand-held devices but also for central office equipments. Based on the studies of real-life ASICs, this paper first analyzes power consumption in each step of the popular syndrome-based decoding of BCH codes. It identifies Chien search, the most commonly used procedure in decoding, as the most power consuming operation. This paper further develops a low power decoding technique that tackles the power issues of the Chien search. The proposed technique is effective in power reduction and simple to implement.
Better branding: brand names can influence consumer choice (2013)

Purpose – Researchers agree that the choice of brand name for a product can alter the consumers ' judgment about the product and their purchase decision-making process. With competition getting fiercer and product quality becoming more homogenous, a “better” brand name can be decisive in product choice if the consumers compare several products. The purpose of this research is to offer new physiological insights about how brand names are processed in the consumer ' s brain in order to identify potential determinants of “better” brand names. Design/methodology/approach – Using valence and activation ratings, reaction time, and functional magnetic resonance imaging (fMRI), the authors show the interaction of key brand name dimensions with the consumer purchase decision-making process, as well as the neurophysiological basis of consumer preference for certain types of brand names. Findings – The authors ' research shows that it has a positive effect on consumer choice to include in the brand name hints at the key benefits of the underlying product. Practical implications – The authors ' results demonstrate that fMRI is able to provide important insights for brand practitioners. Originality/value – Current research has neither focused on the interaction of brand name dimensions with the consumer purchase decision-making process nor provided insight about the physiological drivers of brand perception. In their research, the authors applied for the first time neurophysiological methodologies and fMRI to questions related to brand names, resolving questions that have not been answered due to the methodological limitations of social sciences.
ON THE DYNAMICS OF HELICOIDAL FERROELECTRIC SMECTIC [MATH] LIQUID CRYSTALS (1979)

The low frequency polarization fluctuation spectrum of a chiral system undergoing a helicoidal ferroelectric smectic A → smectic [MATH] phase transition is evaluated for the wave vector q = 0 both above and below Tc. It has a soft mode character above Tc, while it consists of the soft mode part and Goldstone mode part below Tc. In the absence of the flexoelectric coupling between the polarization and the tilt of molecules both the frequency and the dielectric strength of the Goldstone mode do not depend on temperature. The flexoelectric coupling influences the temperature dependence so that the Goldstone mode dielectric strength goes to zero at Tc.
Effects of PETN and ISDN on vascular dysfunction and oxidative stress in an experimental model of Diabetes (2010)

Background Vascular complications in diabetes mellitus (DM) are associated with increased reactive oxygen species (ROS) formation. Therefore we tested, if treatment with PETN, which has been shown to induce the antioxidant enzyme heme oxygenase‐1, improves ROS formation and vascular function in a diabetic rat model. Methods/Results DM was induced by a single i.v. injection of streptozotocin (STZ, 60mg/kg) in male Wistar rats. After 8 weeks of PETN (15mg/kg/d) vs. isosorbid dinitrate (ISDN, 10 mg/kg/d) vs. isosorbide‐5‐mononitrate (ISMN, 75mg/kg/d) treatment, rats were sacrificed. STZ‐treated rats showed an increase in vascular and cardiac ROS production, detected by HPLC. Endothelial function, measured by isometric tension studies, was impaired. PETN therapy improved almost all parameters more efficiently than ISDN, while ISMN had no protective effects. Some rats were treated with insulin (2.5U/d). Insulin normalized all parameters completely proving that STZ‐induced vascular dysfunction depends on hyperglycemia but not on unspecific toxicity of the compound. Conclusion In diabetic rats, PETN showed more pronounced antioxidative effects than ISDN. Insulin normalized all parameters and thereby identified the underlying mechanism of cardiovascular dysfunction in STZ‐induced DM to strictly depend on insulin levels highlighting the importance of this model.
Association of kidney transplantation with mortality on hemodialysis after graft failure (2021)

This Japanese cohort study suggested that a cardiovascular mortality risk of transplant-failure patients could be significantly lower than that of transplant-naïve patients, while there might be a trend toward a higher infection-related mortality risk in transplant-failure patients. However, this retrospective, single-country study can introduce an immortal time bias in transplant-failure patients, and limit the external validity. Further prospective studies are warranted to improve the comparability of outcomes between transplant-failure and transplant-naïve patients, and to examine worldwide the generalizability of the potential cardiovascular benefit of kidney transplantation even after returning to dialysis.
Negative differential resistance in planar graphene quantum dot resonant tunneling diodes (2017)

Negative differential resistance (NDR), an electronic property present in resonant tunneling diodes, enables high performance terahertz frequency oscillators and multi-state logic and memory devices. An important measure of NDR is the peak-to-valley current ratio (PVCR) and this has been extremely lacking in solid-state NDR devices. Here we show how a dimensional mismatch between the quantum dot and the electrodes of a planar graphene Double Barrier Resonant Tunneling Diode (DB-RTD) greatly enhances the PVCR of the device up to a ratio of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . Our findings suggest a promising future for the application of planar graphene quantum dot devices in next generation electronics.
Characterization of dielectric charging in RF MEMS capacitive switches (2006)

RF MEMS capacitive switches show great promise for use in wireless communication devices such as mobile phones, but the successful application of these switches is hindered by reliability concerns: charge injection in the dielectric layer (SiN) can cause irreversible stiction of the moving part of the switch. We present a new way to characterize charge injection. By stressing the dielectric with electric fields on the order of 1 MV/cm, we inject charge in the dielectric, and use a new method to measure the effects it has on the C-V curve. Instead of measuring the change in the pull-in voltage, this method measures the change in the voltage at which the capacitance is minimal. This way, no extra charge is injected during the measurement of the amount of injected charge, which reduces the effect it has on the tested switches, so that the effect of the intentionally induced stress voltage is not obscured by the measurement method.
Hierarchical order in different organisational forms (2009)

Studies of the context in which discourse occurs focusing on hierarchical order in different organisational forms, with implications for organizational theories which make relevant assumptions about structure and constraint.
Crystal structures classifier for an evolutionary algorithm structure predictor (2008)

USPEX is a crystal structure predictor based on an evolutionary algorithm. Every USPEX run produces hundreds or thousands of crystal structures, some of which may be identical. To ease the extraction of unique and potentially interesting structures we applied usual high-dimensional classification concepts to the unusual field of crystallography. We experimented with various crystal structure descriptors, distinct distance measures and tried different clustering methods to identify groups of similar structures. These methods are already applied in combinatorial chemistry to organic molecules for a different goal and in somewhat different forms, but are not widely used for crystal structures classification. We adopted a visual design and validation method in the development of a library (CrystalFp) and an end-user application to select and validate method choices, to gain userspsila acceptance and to tap into their domain expertise. The use of the classifier has already accelerated the analysis of USPEX output by at least one order of magnitude, promoting some new crystallographic insight and discovery. Furthermore the visual display of key algorithm indicators has led to diverse, unexpected discoveries that will improve the USPEX algorithms.
Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation (2018)

Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L (Apo-2 ligand), is a cytokine of the TNF superfamily acknowledged for its ability to trigger selective apoptosis in tumor cells while being relatively safe towards normal cells. Its binding to its cognate agonist receptors, namely death receptor 4 (DR4) and/or DR5, can induce the formation of a membrane-bound macromolecular complex, coined DISC (death-signaling inducing complex), necessary and sufficient to engage the apoptotic machinery. At the very proximal level, TRAIL DISC formation and activation of apoptosis is regulated both by antagonist receptors and by glycosylation. Remarkably, though, despite the fact that all membrane-bound TRAIL receptors harbor putative glycosylation sites, only pro-apoptotic signaling through DR4 and DR5 has, so far, been found to be regulated by <i>N</i>- and <i>O</i>-glycosylation, respectively. Because putative <i>N</i>-glycosylation sequons and <i>O</i>-glycosylation sites are also found and conserved in all these receptors throughout all animal species (in which these receptors have been identified), glycosylation is likely to play a more prominent role than anticipated in regulating receptor/receptor interactions or trafficking, ultimately defining cell fate through TRAIL stimulation. This review aims to present and discuss these emerging concepts, the comprehension of which is likely to lead to innovative anticancer therapies.
A View on Formation Gap in Transition Metal Hydrides and Its Collapse (2021)

Late transition metals (LTMs) do not form hydrides under conventional experimental conditions except for palladium (Pd). The incorporation of a small amount of metal with low electronegativity converts LTMs into hydrogen (H) storage intermetallics (IMs) such as LaNi<sub>5</sub>. We examined the critical property of the H absorbing ability of LTMs and found that the lattice softness of Pd is a unique parameter for H insertion. This idea is applicable to H storage IMs. Indeed, negatively charged LTM ions, such as Ni<sup>δ-</sup> in LaNi<sub>5</sub>, play a crucial role in hydrogenation. These ions cause lattice softening, which renders H solution possible. As a result, we propose that lattice softness can be an effective criterion for the development of new H storage IMs.
Cyclic Pentapeptide Endothelin A Receptor Antagonists with Attenuated in Vivo Clearance. (1996)

A series of analogues of BQ-123 (1), a potent cyclic pentapeptide endothelin A receptor antagonist, with amino acids linked to the side-chain of the Pro residue via an ester linkage was synthesized. All analogues synthesized exhibited potent endothelin A receptor binding affinity similar to that of 1. Of the synthesized analogues, the Lys, Arg and N alpha,N epsilon-dimethyllysine analogues, 9d-f, exhibited about a three-fold attenuation of in vivo clearance compared with 1. In rats, these analogues exhibited a 3-fold-higher plasma concentration and a longer retention time in plasma as compared with those of 1. The attenuated in vivo clearance was thought to be a consequence of decreased extraction of the compounds from the blood via the hepatic anion transport system, which efficiently extracts 1 from the blood.
Validité discriminante d'épreuves de dépistage de la dyslexie chez des enfants de CE2-CM1 (2007)

Dyslexia is a specific disorder of written language. Researches led on dyslexia origin have conducted to multiple hypotheses (i.e. phonological hypothesis, rapid auditory processing hypothesis, cerebellum hypothesis, etc.). These multiple hypotheses created various diagnosis methods and treatments which are sometimes inadequate. In this context, practitioners need an automatic tool to help in diagnosing dyslexia. This tool must evaluate children's own deficit and advise adapted rehabilitation. This paper presents the conception of a preliminary test containing the most representative dyslexia evaluation tasks from literature and the first results concerning the discriminatory validity of this preliminary test in school age children (8-10 years).
BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra (2018)

Circular dichroism (CD) spectroscopy is a widely used method to study the protein secondary structure. However, for decades, the general opinion was that the correct estimation of β-sheet content is challenging because of the large spectral and structural diversity of β-sheets. Recently, we showed that the orientation and twisting of β-sheets account for the observed spectral diversity, and developed a new method to estimate accurately the secondary structure (PNAS, 112, E3095). BeStSel web server provides the Beta Structure Selection method to analyze the CD spectra recorded by conventional or synchrotron radiation CD equipment. Both normalized and measured data can be uploaded to the server either as a single spectrum or series of spectra. The originality of BeStSel is that it carries out a detailed secondary structure analysis providing information on eight secondary structure components including parallel-β structure and antiparallel β-sheets with three different groups of twist. Based on these, it predicts the protein fold down to the topology/homology level of the CATH protein fold classification. The server also provides a module to analyze the structures deposited in the PDB for BeStSel secondary structure contents in relation to Dictionary of Secondary Structure of Proteins data. The BeStSel server is freely accessible at http://bestsel.elte.hu.
Evaluation of Antiallergic Effects of Extracts from Ten Kinds of Vegetables Using Three in vitro Assay Systems (1998)

In vitro antiallergic activity of the 70% ethanol fraction (Scheme 1) from ten kinds of vegetables was investigated using three types of assay systems, which are based on inhibition of histamine release from rat peritoneal mast cells and rat basophilic leukemia cells (RBL-2H3), and inhibition of hyaluronidase activity. The fraction from cabbage showed a strong antiallergic effect in all of the in vitro assays, while the fractions from tomato, red cabbage and watercress showed strong antiallergic effects in two of the in vitro assays. These results suggested that the fractions from four vegetables exhibit antiallergic activity by acting on multiple points in a series of immediate-type allergic reactions.
Multiple internal reflection fluorescence spectrometry (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple internal reflection fluorescence spectrometryN. J. Harrick and George I. LoebCite this: Anal. Chem. 1973, 45, 4, 687–691Publication Date (Print):April 1, 1973Publication History Published online1 May 2002Published inissue 1 April 1973https://pubs.acs.org/doi/10.1021/ac60326a001https://doi.org/10.1021/ac60326a001research-articleACS PublicationsRequest reuse permissionsArticle Views268Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts