gebhart/patrepeval huggingface dataset:
Développement de nouveaux antagonistes de l’interleukine-15 (2016)

L’IL-15 et l’IL-2 sont deux cytokines fonctionnellement tres proches et sont necessaires a l’activation et la proliferation des cellules immunitaires telles que les cellules NK et les lymphocytes T CD8+. Le role activateur de l’IL-15 et de l’IL-2 fait de celles-ci deux acteurs importants dans les maladies auto-immunes et les maladies inflammatoires. Dans cette etude, nous avons developpe un premier antagoniste nomme NANTIL-15 qui se fixe au recepteur IL-15Ra mais ne recrute pas la chaine IL-15Rb et inhibe specifiquement l'IL-15. Le NANTIL-15 n’affecte pas l’homeostasie des cellules NK et des lymphocytes T CD8+ chez la souris. Dans un modele murin d’arthrite, le NANTIL-15 reduit les signes cliniques et le recrutement des lymphocytes T CD8+ dans le site inflammatoire. Le deuxieme antagoniste developpe est nomme BiG et se fixe au recepteur IL-2/15Rb avec une haute affinite mais ne recrute pas la chaine IL-2/15Rg. BiG inhibe les fonctions effectrices de l’IL-15 et de l’IL-2 sur les cellules NK et les lymphocytes T CD8+. En presence de la chaine IL-2Ra, BiG n’a aucun impact sur les fonctions de l’IL-2 sur les cellules T-reg. Ainsi BiG favorise le ratio regulateur/effecteur du systeme immunitaire. Dans un modele murin de greffe de peau, BiG permet de ralentir le rejet des greffons. Enfin des travaux realises sur la lignee de cellules humaines NK-92 et les cellules NK humaines primaires, ont permis de mettre en evidence une « trans-presentation homotypique » de l’IL-15. En effet les cellules NK chargees avec l’IL-15 et non l’IL-2, trans-presentent cette IL-15 aux cellules NK voisines. Ce travail a egalement montre que cette trans-presentation homotypique est dependante du contact physique entre les cellules et impliquerait les molecules d’adhesion tel que LFA-1.
Properties of Calcium Phosphate Ceramics in Relation to Their In Vivo Behavior (2000)

Blokhuis, Taco J. MD; Termaat, Marco F. MD; den Boer, Frank C. MD; Patka, Peter MD, PhD; Bakker, Fred C. MD, PhD; Haarman, Henk J. Th. M. MD, PhD Author Information
Effet de la température d’implantation sur les propriétés électriques du PPP (1992)

L’effet de la température d’implantation a été essentiellement considéré pour les basses températures : la mobilité des porteurs n’est finalement que légèrement améliorée par rapport à celle obtenue à température ambiante.
Effect of double-sided (Pb0.72La0.28)Ti0.93O3 buffer layers on the ferroelectric properties of Pb(Zr0.52Ti0.48)O3 thin films (2005)

We deposited the Pb(Zr0.52Ti0.48)O3 (PZT) thin films with single and double-sided (Pb0.72La0.28)Ti0.93O3 (PLT) buffers by using a pulsed-laser deposition method. With the PLT buffer layers, the remanent polarization values increased, and a remanent polarization value of 33.4μC∕cm2 was obtained when 10-nm-thick double-sided PLT buffer layers were used. While the coercive field of films slightly increased only with a single-sided PLT buffer, it decreased again by adding the top PLT buffer layer. The film with double-sided PLT buffer also exhibited good fatigue endurance after 109 switching cycles even without oxide electrodes, mainly because the accumulated charges were compensated at the interface junction between the PLT buffer layer and the electrode.
Adaptive packet video streaming over IP networks: a cross-layer approach (2005)

There is an increasing demand for supporting real-time audiovisual services over next-generation wired and wireless networks. Various link/network characteristics make the deployment of such demanding services more challenging than traditional data applications like e-mail and the Web. These audiovisual applications are bandwidth adaptive but have stringent delay, jitter, and packet loss requirements. Consequently, one of the major requirements for the successful and wide deployment of such services is the efficient transmission of sensitive content (audio, video, image) over a broad range of bandwidth-constrained access networks. These media will be typically compressed according to the emerging ISO/IEC MPEG-4 standard to achieve high bandwidth efficiency and content-based interactivity. MPEG-4 provides an integrated object-oriented representation and coding of natural and synthetic audiovisual content for its manipulation and transport over a broad range of communication infrastructures. In This work, we leverage the characteristics of MPEG-4 and Internet protocol (IP) differentiated service frameworks, to propose an innovative cross-layer content delivery architecture that is capable of receiving information from the network and adaptively tune transport parameters, bit rates, and QoS mechanisms according to the underlying network conditions. This service-aware IP transport architecture is composed of: 1) an automatic content-level audiovisual object classification model; 2) a reliable application level framing protocol with fine-grained TCP-Friendly rate control and adaptive unequal error protection; and 3) a service-level QoS matching/packet tagging algorithm for seamless IP differentiated service delivery. The obtained results demonstrate, that breaking the OSI protocol layer isolation paradigm and injecting content-level semantic and service-level requirements within the transport and traffic control protocols, lead to intelligent and efficient support of multimedia services over complex network architectures.
Fabrication of 3D fine scale PZT components by ink-jet prototyping process (2005)

Different investigations have been carried out to optimize an ink-jet printing technique, devoted to the fabrication of 3D fine scale PZT parts, by adjustment of the fluid properties of the ceramic suspensions and by controlling the ejection and impact phenomena. A 10 vol% PZT loaded suspension characterized by a Newtonian behavior, corresponding to a viscosity of lOmPa.s and to a ratio Re/We 1/2 of 5.98 has been selected. The ejection and impact phenomena strongly depend on the driving parameters of the printing head, in particular the formation of the droplet, with satellite or not, as well as its velocity and volume which are function of the pulse amplitude. Moreover, the conditions of ejection (droplet velocity and volume) control the characteristics of the deposit (definition, spreading, thickness uniformity). Sintered PZT pillar array has been achieved by ink-jet printing with a definition equal to 50μm. These structures could be very useful to improve the performances of 1-3 ceramic polymer composites for imaging probes or more generally for ultrasonic transducers and also of micro-deformable mirrors for optical adaptive systems.
“Progressive Education and a Welcoming Church”: Vatican II, Feminism, and Sister Aloysius’ Uncertainty in John Patrick Shanley’s Doubt (2012)

Here, we present an inexpensive rapid-prototyping method that allows researchers and children to quickly assemble multi-layered microfluidic devices from easily pre-fabricated building blocks. We developed low-cost (<$2) kits based on laser-cut acrylic building block pieces and double-sided tape that allow users to generate water droplets in oil, capture living cells, and conduct basic phototaxis experiments. We developed and tested a 90-min lesson plan with children aged 12-14 yr and provide here the instructions for teachers to replicate these experiments and lessons. All parts of the kit are easy to make or order. We propose to use such easy to fabricate kits in labs with no access to current microfluidic tools as well as in classroom environments to get exposure to the powerful techniques of microfluidics.
Seismic response of a light rail transit station equipped with braced viscous damper (2016)

The use of the Light Rail Transit (LRT) system is currently preferred because LRT is sustainable, improves travel options and facilitates swift mobility in urban areas. Hence, the structural stability and safety of this public transportation system against seismic occurrences are indispensable. Given that these structures cannot be considered conventional frames because of their complex architectural design, focussing meticulously on reliable seismic design codes and structural rehabilitation techniques is vital for the design of the lateral resistance system. One Malaysian LRT station is considered in this study, and the seismic response of this train station when equipped with supplementary viscous damper devices is evaluated. Thus, the LRT station is modelled through finite element simulation. The methods of seismic analysis are limited to linear seismic analyses, namely, response spectrum and time history analyses. Results derived in this study show a significant improvement in structural response when the station is fitted with dampers; approximately 40% reduction in displacement is observed at the top joint of the roof. Furthermore, the lateral base shears decrease by approximately 70%.
Regulation of glycolysis via reversible enzyme binding to the membrane protein, band 3 (1993)

Most metabolic pathways are regulated by feedback inhibition/activation or by covalent modification of a regulatory enzyme. In erythrocytes, however, we demonstrate that glycolysis can be modulated over 30-fold by controlling the availability of glycolytic enzyme binding sites at the extreme N terminus of the anion transporter, band 3. Direct obstruction of these inhibitory sites by anti-peptide Fab's against residues 1-15 of band 3 promotes an approximately 3-fold increase in the rate of lactate production. In contrast, enrichment of the erythrocyte cytoplasm with the band 3 peptide against which the above antibodies were raised results in a more than 10-fold decrease in the rate of lactate accumulation. Control peptides and their derived antipeptide antibodies corresponding to other sequences of band 3 or glycophorin were found to have no effect on lactate production. Analysis of changes in glycolytic intermediates during Fab treatments suggests that hexokinase may be one enzyme that is modulated by association with band 3. We conclude that the extreme N terminus of band 3 can bind and inhibit glycolytic enzymes in vivo and that it probably participates in control of red cell glycolysis.
Virtualizing register context (2005)

A processor designer may wish for an implementation to support multiple register contexts for several reasons: to support multithreading, to reduce context switch overhead, or to reduce procedure call/return overhead by using register windows. Conventional designs require that each active context be present in its entirety, increasing the size of the register file. Unfortunately, larger register files are inherently slower to access and may lead to a slower cycle time or additional cycles of register access latency, either of which reduces overall performance. We seek to bypass the trade-off between multiple context support and register file size by mapping registers to memory, thereby decoupling the logical register requirements of active contexts from the contents of the physical register file. Just as caches and virtual memory allow a processor to give the illusion of numerous multi-gigabyte address spaces with an average access time approaching that of several kilobytes of SRAM, we propose an architecture that gives the illusion of numerous active contexts with an average access time approaching that of a single active context using a conventionally sized register file. This dissertation introduces the virtual context architecture, a new architecture that virtualizes logical register contexts. Complete contexts, whether activation records or threads, are kept in memory and are no longer required to reside in their entirety in the physical register file. Instead, the physical register file is treated as a cache of the much larger memory-mapped logical register space. The implementation modifies the rename stage of the pipeline to trigger the movement of register values between the physical register file and the data cache. With the same size register file as a non register windowed machine, this architecture is within 1% of the execution time of an idealized register window machine. The virtual context architecture enables support for both register windows and simultaneous multithreading without increasing the size of the register file, increasing the performance by 50% over a single thread and 30% over a conventional multithreaded architecture.
Structural Determinants of CX-4945 Derivatives as Protein Kinase CK2 Inhibitors: A Computational Study (2011)

Protein kinase CK2, also known as casein kinase-2, is involved in a broad range of physiological events including cell growth, proliferation and suppression of apoptosis which are related to human cancers. A series of compounds were identified as CK2 inhibitors and their inhibitory activities varied depending on their structures. In order to explore the structure-activity correlation of CX-4945 derivatives as inhibitors of CK2, in the present study, a set of ligand- and receptor-based 3D-QSAR models were developed employing Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Index Analysis (CoMSIA). The optimum CoMFA (R(cv) (2) = 0.618, R(pred) (2) = 0.892) and CoMSIA (R(cv) (2) = 0.681, R(pred) (2) = 0.843) models exhibited reasonable statistical characteristics for CX-4945 derivatives. The results indicated that electrostatic effects contributed the most to both CoMFA and CoMSIA models. The combination of docking analysis and molecular dynamics (MD) simulation showed that Leu45, Lys68, Glu81, Val116, Asp175 and Trp176 of CK2 which formed several direct or water-bridged H-bonds with CX-4945 are crucial for CX-4945 derivatives recognition to CK2. These results can offer useful theoretical references for designing more potent CK2 inhibitors.
Seismic data acquisition (1989)

Seismic data acquisition involves a number of different subjects, and I am not expert in each of these areas. In fact, it is possible that such an expert in all phases of seismic acquisition may be entirely hypothetical. My approach, therefore, will be to list and briefly describe some ideas which I think are likely to be important in the future.
ESTIMATION OF YOUNG'S MODULUS OF ULTRATHIN POLYMERIC FILMS FOR NANOIMPRINT LITHOGRAPHY BY USE OF ATOMIC FORCE MICROSCOPE (2006)

The tests concerning the estimation of the Young`s modulus for ultrathin polymeric films, de-voted for nanoimprint lithography, with the use of atomic force microscope (AFM) were carried out. Some results will be discussed in the paper. 1.
Meloidogyne ulmi: een nieuwe iepenparasiet in Nederland? (2008)

eloidogyne ulmi In de land- en tuinbouw zijn plant-parasitaire nematoden een bekend fenomeen: in meer of mindere mate parasiteren deze draadwormen op vrijwel alle gewassen. Schade varieert van groeireductie tot complete misoogsten. Wereldwijd behoort de groep van de wortelknobbelnematoden, ofwel wortelknobbelaaltjes, tot de meest schadelijke nematodensoorten. De wortelknobbelaal maakt gallen rond de wortel, waarin hij kruipt om zich van hieruit te voeden
Are we effectively monitoring and treating vitamin D deficient patients with tuberculosis? (2013)

INTRODUCTION Hypovitaminosis D is associated with active tuberculosis (TB). It is controversial whether the condition predisposes to TB infection or is a result of it. AIMS Following release of local guidelines on vitamin D replacement, the aim was to examine if vitamin D replacement was effective in TB patients prior to this. METHODS TB cases from March 2011 - March 2012 treated at King George Hospital were identified via London TB Register. The hospital pathology database identified patients that had vitamin D levels measured and if this had been rechecked following supplementation. Levels were classified as replete; insufficient; deficient. Chronic kidney disease patients were excluded. RESULTS 124 patients had vitamin D levels measured and commenced on supplementation. Of these, 97 were deficient, 25 had insufficient levels and 2 were replete. 30 patients had vitamin D levels re-checked (mean interval of 184 days). Initial tests in this group showed that 7 patients had insufficient levels and 23 were deficient. Following supplementation, 6 patients had insufficient levels, 21 were deficient and 3 were replete. 12 patients had lower vitamin D levels than at diagnosis. 3 were unchanged. CONCLUSIONS Results suggest vitamin D supplementation was ineffective in TB patients. Causative mechanism(s) remain unclear but could be due to disease process, indicate lack of patient compliance or a need for local guidelines (primary and secondary care). Re-audit in line with local guidelines and anticipated NICE guidelines may add clarity as to the causative mechanism(s).
A Fluorescent Study of Histamine Release from a Single Mast Cell of the Rat Mesentery (1970)

Microelectrophoretic application of histamine releasers was made to a single mast cell of the rat mesentery. When topically applied close to the cell membrane, compound 48/80, sinomenine, toluidine blue, ATP and a-chymotrypsin all induced a local degranulation associated with the loss of histamine fluorescence in the degranulated area. Extruded granules showed no fluorescence.Intracellular application of these compounds, and also of Ca2+ and Na+, did not affect histamine fluorescence of the mast cell, although n-decylamine caused disappearance of the fluorescence with either intra- or extracellular application.Metachromatic granules were revealed by re-staining with thionine in the mast cell which had lost histamine fluorescence after a diffuse extracellular application of these releasers.
Fluid Flow in Faults - Modelling with the Athena Reservoir Simulator (2003)

The architecture of faults has significant influence on fluid flow behaviour in deformed reservoirs. The internal architecture and geometry of fault zones may vary from those with a simple geometry and structure to those with multiple fault strands within a complex architecture.
Microwave absorbing properties based on polyaniline/magnetic nanocomposite powders (2015)

Polyaniline/(1 − <italic>x</italic>)BaFe<sub>12</sub>O<sub>19</sub>/CaFe<sub>2</sub>O<sub>4</sub>/<italic>x</italic>CoFe<sub>2</sub>O<sub>4</sub> nanocomposite powders were successfully prepared by an <italic>in situ</italic> polymerization method.
Selecting the Golomb Parameter in Rice Coding (2004)

We examine the use of Golomb-power-of-2 (GPO2) codes to efficiently and loss-lessly encode sequences of nonnegative integers from a discrete source. Specifically, we’re interested in the problem of selecting which GPO2 code to use for a source or a block of samples; this problem is at the heart of the well-known Rice entropy cod-ing algorithm. We’re particularly concerned with the case where the mean sample value is known or can be estimated. We derive bounds on the optimum code parameter as a function of the mean sample value. These bounds establish that no more than three possible code choices can be optimum for a given mean sample value. We derive a simple method to select the optimum GPO2 code for a geometrically distributed source given the mean value. We also devise a simpler code selection procedure that generalizes previously known methods. Both code selection methods can be implemented using only integer arithmetic and table look-ups, and require no divisions. We show that, for any source with known mean, the GPO2 code parameter selected under this simple procedure is always within one of the optimum code parameter for the source, and that the added cost due to suboptimum parameter selection under this procedure is never more than 1/2 bit per sample and no more than about 13 percent inefficiency. We investigate the use of both code selection procedures as lower complexity alternatives to Rice coding within the emerging Consultative Committee for Space Data Systems (CCSDS) image compression standard. For the images tested, both code selection methods produce negligible added rate compared to optimal code selection as in Rice coding. I.
Medicare and Medical Students (1966)

Of 1,500 medical students at four medical schools, 1,053 anonymously and voluntarily completed questionnaires eliciting information on their knowledge and attitudes toward the Medicare program. Their responses indicate that 80% of them have little or no knowledge regarding the details of the program. Despite this lack of information, a large majority of the students have opinions which are, in general, negative. The attitudes and opinions expressed were remarkably homogeneous in each of the four classes at each school. There were differences between the schools which may depend upon the ecology of the school, ie, socioeconomic background of students and types of careers pursued by the graduates. On the basis of data available, it would seem that a significant proportion of medical students believe that their career plans have been altered by this legislation. This ranges from a high of 24.6% in the fourth-year class of school C to a low of 3.5% of the first-year class in school B.
Optimisation of the laser cutting process by the Downhill simplex method (2001)

status: Published
Development of Presumptive Mammotrophs in Isografts Is Dependent on the Endocrine State of the Host* (1980)

Hormonal influences on the cytodifferentiation and functional development of anterior pituitary tissue are not well understood. To study this problem, we have isografted pituitary primordia from 15-day-old rat embryos to beneath the kidney capsule of adult females and allowed the grafts to develop for 28 days. Hosts were hypophysectomized either at the time of grafting (chronic hypophysectomy) or 24 days after receiving grafts (late hypophysectomy) or left intact. When the hosts were sacrificed, plasma samples were taken for RIA and the grafts were homogenized for RIA, fixed for electron microscopy, or processed for light microscopic immunocytochemistry. In chronically hypophysectomized hosts, mammotrophs were rare, as judged by ultrastructural and immunocytochemical staining characteristics. The transplants contained an average of 84 ng PRL/graft, and plasma levels of PRL were the same as those in hypophysectomized controls without grafts. In comparison with the chronically hypophysectomized animals, transplants in intact females contained numerous mammotrophs (P < 0.001). PRL levels of approximately 1570 ng/graft and 27 ng/ml plasma were measured in late hypophysectomized females; these were significant increases (P < 0.005 in each case) over levels in the chronically hypophysectomized group. Grafts in late hypophysectomized hosts given 2 μg 17β-estradiol daily contained an average of 6360 ng PRL, and host circulating PRL levels were 81 ng/ml, significantly higher (P < 0.001) than those in late hypophysectomized animals not receiving estradiol treatments. This study indicates that pituitary primordia respond differently to transplantation beneath the kidney capsule than their adult counterparts and suggests that mammotroph differentiation is largely independent of direct influences by hypothalamic regulatory hormones but may be dependent upon other hormones such as estrogen (Endocrinology 106: 1246, 1980)