gebhart/patrepeval huggingface dataset:
Organische Synthese im Mikroreaktor – Heterogen katalysierte Epoxidierung von 1,3‐Butadien (2009)

Abstract Diese Arbeit untersucht die Machbarkeit der Ag‐katalysierten Epoxidierung von 1,3‐Butadien (1,3‐BD) zu 3,4‐Epoxy‐1‐buten (EpB) in einem am Forschungszentrum Karlsruhe entwickelten Mikroreaktor (MR) [1]. Für Vorversuche kommt ein Rohrreaktor (RR) zum Einsatz. Als Katalysator wird ein α‐Al 2 O 3 ‐Träger eingesetzt, auf dem die Aktivkomponenten aufgebracht sind. Die Epoxidierung erfolgt im Bereich von 180 °C bis 320 °C und Raumgeschwindigkeiten (RG) von 2950 h –1 bis 17 701 h –1 bei Umgebungsdruck in einem Katalysatorteststand. Die höchste EpB‐Selektivität von 52 % wird bei einem 1,3‐BD‐Umsatz von 2,1 % und einer RG von 8851 h –1 mit mikrostrukturierten Ti‐Folien bei 240 °C erreicht.
Production of FMDV virus-like particles by a SUMO fusion protein approach in Escherichia coli (2009)

Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. Some VLPs have been proven successful as vaccines, and others have recently found applications as carriers for foreign antigens or as scaffolds in nanoparticle biotechnology. However, production of VLP was usually impeded due to low water-solubility of recombinant virus capsid proteins. Previous studies revealed that virus capsid and envelope proteins were often posttranslationally modified by SUMO in vivo, leading into a hypothesis that SUMO modification might be a common mechanism for virus proteins to retain water-solubility or prevent improper self-aggregation before virus assembly. We then propose a simple approach to produce VLPs of viruses, e.g., foot-and-mouth disease virus (FMDV). An improved SUMO fusion protein system we developed recently was applied to the simultaneous expression of three capsid proteins of FMDV in E. coli. The three SUMO fusion proteins formed a stable heterotrimeric complex. Proteolytic removal of SUMO moieties from the ternary complexes resulted in VLPs with size and shape resembling the authentic FMDV. The method described here can also apply to produce capsid/envelope protein complexes or VLPs of other disease-causing viruses.
RADIOGRAPHIC EVALUATION OF POLYETHYLENE WEAR IN ACETABULAR COMPONENTS: COMPARISON OF 2D AND 3D MEASUREMENT TECHNIQUES WITH ASSESSMENT OF INTEROBSERVER VARIATION (2003)

The purpose of this study was to compare the 2D and 3D linear and volume wear readings of the three most commonly used methods for measuring polyethylene wear: the Livermore, Devane and Martell techniques. Inter-observer variation of measurements using the techniques of Devane and of Martell on conventional radiographs was also performed. The radiographs of 80 patients (mean age 60+/−10 yrs) who had a Harris-Galante I total hip arthroplasty were measured. Nine different reviewers for the Devane technique readings including Dr Devane and eight reviewers for the Martell technique readings including Dr Martell made blinded independent wear observations for each radiograph set. One reviewer measured the 20 annual linear wear rate for all radiograph sets using the 2D Livermore technique. Inter-observer variation as a function of patient, reviewer, and total variation was statistically assessed using variance component analysis. Mean wear measured using the Livermore technique was the same as with the Devane and Martell method, but with a greater variation. Comparison of the Devane and Martell method for patient STD, reviewer STD, error STD (multiple reviews of same radiographs), total STD (randomly picked reviewer), mostly show a mean 50% lower STD with the Devane technique. Correlation (correlation coefficient of two randomly selected reviewers) is significantly better with the Devane technique.
Achondroplasia natural history study (CLARITY): 60-year experience in orthopedic surgery from four skeletal dysplasia centers (2023)

Orthopedic surgery was a common occurrence in achondroplasia with 29.7% of patients undergoing at least one orthopedic procedure. Spine surgery (12.7%) was less common and occurred at a later age than lower extremity surgery (21.2%). Cervicomedullary decompression and hydrocephalus with shunt placement were associated with an increased risk for spine surgery. The results from CLARITY, the largest natural history study of achondroplasia, should aid clinicians in counseling patients and families about orthopedic surgery.
Throughput maximization for energy harvesting two-hop networks (2013)

In wireless networks, management of harvested energy is important due to limited and stochastic energy sources. In this paper, throughput maximization for energy harvesting two-hop communication with half-duplex relays is considered. Optimal transmission policies are found for one relay and two parallel relays under the assumption of known energy arrivals at the source and the relays. For each case, a convex optimization problem is formulated to efficiently solve and identify properties of the optimal transmission policies. Performance comparisons are provided to investigate the impact of multiple relays and energy harvesting.
South Atlantic volcanic margins (1997)

The Early Cretaceous South Atlantic continental break-up and initial sea-floor spreading were accompanied by large-scale, transient volcanism emplacing the Paraná-Etendeka continental flood basalts and voluminous extrusive constructions on the conjugate margins south of the Torres Arch–Abutment Plateau. On the North Namibia margin we interpret four main tectono-magmatic crustal units: (1) oceanic crust; (2) thickened oceanic crust covered by huge seaward-dipping wedges; (3) a c. 150 km wide break-up related rift zone partly covered by the dipping wedges; and (4) thicker continental crust, partly deformed by Palaeozoic extension, east of the Early Cretaceous rift. Similar settings also characterize other South Atlantic margin segments. We infer an up to 300 km wide and 2400 km long rift zone representing lithospheric extension leading to breakup and formation of the South Atlantic volcanic margins. Comparison with other volcanic margins demonstrates, in spite of local and regional differences, gross similarities in tectono-magmatic style, crustal units and dimensions.
Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies (2020)

Cancer has no borders: Generation and analysis of molecular data across multiple centers worldwide is necessary to gain statistically significant clinical insights for the benefit of patients. Here we conceived and standardized a proteotype data generation and analysis workflow enabling distributed data generation and evaluated the quantitative data generated across laboratories of the international Cancer Moonshot consortium. Using harmonized mass spectrometry (MS) instrument platforms and standardized data acquisition procedures, we demonstrate robust, sensitive, and reproducible data generation across eleven international sites on seven consecutive days in a 24/7 operation mode. The data presented from the high-resolution MS1-based quantitative data-independent acquisition (HRMS1-DIA) workflow shows that coordinated proteotype data acquisition is feasible from clinical specimens using such standardized strategies. This work paves the way for the distributed multi-omic digitization of large clinical specimen cohorts across multiple sites as a prerequisite for turning molecular precision medicine into reality.
H‐Terminated Diamond Field‐Effect Transistors (2009)

This chapter contains sections titled: Introduction Experimental Procedure Results Discussion Summary References
Acute lethal toxicity following passive immunization for treatment of murine cryptococcosis (1997)

Passive immunization with monoclonal antibodies (MAbs) specific for the major capsular polysaccharide of Cryptococcus neoformans alters the course of murine cryptococcosis. During studies of passive immunization for treatment of murine cryptococcosis, we noted the occurrence of an acute, lethal toxicity. Toxicity was characterized by scratching, lethargy, respiratory distress, collapse, and death within 20 to 60 min after injection of antibody. The toxic effect was observed only in mice with a cryptococcal infection and was reduced or absent in the early and late stages of disease. The clinical course and histopathology were consistent with those for shock. There was considerable variation between mouse strains in susceptibility to toxicity. Swiss Webster mice from the Charles River colony were most susceptible, followed by C3H/He, BALB/c, and C57BL/6 mice. DBA/2 mice and Swiss Webster mice from the Simonsen colony were resistant. Acute toxicity was mimicked by injection of preformed complexes of MAb and purified polysaccharide. The toxic effect was also produced by injection of MAbs into mice that were preloaded with polysaccharide. The toxic effect was not blocked by treatment of mice with chloropheniramine or anti-tumor necrosis factor alpha antibodies or by depletion of complement components via pretreatment with cobra venom factor. Toxicity was reduced by treatment of mice with high doses of epinephrine, dexamethasone, or chlorpromazine. Finally, the toxic effect was completely blocked by treatment of mice with the platelet-activating factor antagonist WEB 2170 BS or by pretreatment of mice with the liposome-encapsulated drug dichloromethylene diphosphonate, a procedure which depletes macrophages from the spleen and liver.
Towards a Lightweight Platform for Realizing Agent-based Cyber-Physical Production Systems (2014)

Various roadmaps concerning research and developments for fu-ture factory automation conclude that both information and communication will be key issues for future production systems. These visions imply archi-tectural shifts and, hence, the roadmaps envision (production) systems being able to flexibly adjust their behaviour to changing conditions. This implies changing business conditions, e.g. changing demand or product portfolio, and technical conditions, e.g. technical faults. They provide novel, sophisticated mechanisms, which are enabled by the availability of communication and re-alized by the significantly increased intelligence of computing entities. One means in order to realize these visions are agent-based technologies. Nevertheless, existing agent platforms are either following the heavyweight FIPA standard or implemented in high-level languages not supported by every micro controller. Therefore, a lightweight platform for realizing agent-based cyber-physical production systems (CPPS) is required, which is intro-duced in this presentation.
Immunological tolerance and its breakdown in Chagas heart disease role of parasitokines (2003)

Chagas' disease, a debilitating condition inflicting millions of people in Latin America, is caused by infection with the protozoan parasite Trypanosoma cruzi. One characteristic sequel to the subdued acute infection is electocardiographic alterations in about one third of the patients that reach the chronic phase of disease. Another feature of chronic Chagas' disease is the paucity of parasites in the diseased heart. There have been many debates whether chronic chagasic cardiomyopathy (CCC) is a consequence of parasite persistence or autoimmunity, a central question that will clearly influence the strategies for disease prevention and treatment. In this review, we summarize the pros and cons of each side and provide a novel view on the genesis, and hence treatment of, CCC. In particular, we emphasize the contribution of parasite-derived danger signal, such as parasitokines, to the breakdown of self-tolerance in T. cruzi infection. Accordingly, we argue that a more efficient way of countering immune subversion and autoimmune responses induced by the parasite would be targeting key parasitokines rather than blocking parasitic epitopes cross-reactive with host antigens. Finally, based on current knowledge on immune regulation, especially in transplantation models, we propose that future focus of CCC treatment should rely on efforts to restore the immunological tolerance to self-antigens concurrent with regimens to reduce the parasite load as much as possible through immunological and chemotherapy procedures.
The Management of Research Institutions: A Look at Government Laboratories (1987)

Technology development; project management; employment patterns; research productivity; legal status of support services; functions of senior executives; the role of the sponsoring agency; research diversification; obstacles to technical innovation; organizational structures; and personnel management are addressed.
Mapping Bone Changes at the Proximal Femoral Cortex of Postmenopausal Women in Response to Alendronate and Teriparatide Alone, Combined or Sequentially (2015)

Combining antiresorptive and anabolic drugs for osteoporosis may be a useful strategy to prevent hip fractures. Previous studies comparing the effects of alendronate (ALN) and teriparatide (TPTD) alone, combined or sequentially using quantitative computed tomography (QCT) in postmenopausal women have not distinguished cortical bone mineral density (CBMD) from cortical thickness (CTh) effects, nor assessed the distribution and extent of more localized changes. In this study a validated bone mapping technique was used to examine the cortical and endocortical trabecular changes in the proximal femur resulting from an 18-month course of ALN or TPTD. Using QCT data from a different clinical trial, the global and localized changes seen following a switch to TPTD after an 18-month ALN treatment or adding TPTD to the ALN treatment were compared. Ct.Th increased (4.8%, p < 0.01) and CBMD decreased (-4.5%, p < 0.01) in the TPTD group compared to no significant change in the ALN group. A large Ct.Th increase could be seen for the switch group (2.8%, p < 0.01) compared to a significantly smaller increase for the add group (1.5%, p < 0.01). CBMD decreased significantly for the switch group (-3.9%, p < 0.01) and was significantly different from no significant change in the add group. Ct.Th increases were shown to be significantly greater for the switch group compared to the add group at the load bearing regions. This study provides new insights into the effects of ALN and TPTD combination therapies on the cortex of the proximal femur and supports the hypothesis of an increased bone remodeling by TPTD being mitigated by ALN.
A GPU based interactive modeling approach to designing fine level features (2007)

In this paper we propose a GPU based interactive geometric modeling approach to designing fine level features on subdivision surfaces. Displacement mapping is a technique for adding fine geometric detail to surfaces by using two-dimensional height map to produce photo-realistic surfaces. Due to space inefficiency and time consuming to render displacement map, this technique is generally limited in offline cinematic content creation packages. We propose a new approach to designing fine level features on subdivision surfaces via displacement mapping interactively on the latest GPU. Our method can reduce the bandwidth of the graphics channel by generating complex geometric detail on GPU, without feeding a large number of vertices to the AGP or PCI-E. Moreover, we introduce feature modification tools to flexibly control and adjust the created features. Designers can preview the features at the rendering stage, saving the time to generate the satisfying features on surfaces. The proposed approach is efficient and robust, and can be applied in many interactive graphics applications such as computer gaming, geometric modeling and computer animation.
Bis(1,1,1,5,5,5‐Hexafluro‐2,4‐Pentane‐Dionato)Palladium and its Complexes with 2,2′‐Bipyridine and Bis[2‐(Diphenylphosphino)‐Ethyl]Phenylphosphine (1990)

This chapter contains sections titled: Bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)palladium (2,2′-Bipyridine)(l,1,1,5,5,5-hexafluoro-2,4-pentanedionato)palladium(II) 1,1,1,5,5,5-hexafluoro-2,4-dioxo-3-pentanide [Bis[2-(diphenylphosphino)ethyl]phenylphosphine]-(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)palladium(II)-1,1,1,5,5,5-hexafluoro-2,4-dioxo-3-pentanide.
Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases (2019)

Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs). Oleuropein, the main phenolic component of <i>Olea europaea</i> L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This article is a narrative review focused on the current literature concerning the effect of oleuropein in NCDs, such as neuro- and cardiovascular diseases, diabetes mellitus, chronic kidney diseases, and cancer, by its putative antioxidant and anti-inflammatory activity, but also for its other peculiar actions such as an autophagy inducer and amyloid fibril growth inhibitor and, finally, for its anti-cancer effect. Despite the increasing number of published studies, looking at the beneficial effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein.
Developmental, Audiological, and Speech Perception Functioning in Children After Cochlear Implant Surgery: A Reply—Reply (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Heat-Up Performance of Catalyst Carriers—A Parameter Study and Thermodynamic Analysis (2021)

This study investigates geometric parameters of commercially available or recently published models of catalyst substrates for passenger vehicles and provides a numerical evaluation of their influence on heat-up behavior. Parameters considered to have a significant impact on the thermal economy of a monolith are: internal surface area, heat transfer coefficient, and mass of the converter, as well as its heat capacity. During simulation experiments, it could be determined that the primary role is played by the mass of the monolith and its internal surface area, while the heat transfer coefficient only has a secondary role. Furthermore, an optimization loop was implemented, whereby the internal surface area of a commonly used substrate was chosen as a reference. The lengths of the thin wall and high cell density monoliths investigated were adapted consecutively to obtain the reference internal surface area. The results obtained by this optimization process contribute to improving the heat-up performance while simultaneously reducing the valuable installation space required.
Terminal QoS for real-time 3-D visualization using scalable mpeg-4 coding (2003)

Terminal quality of service is the process of optimally scaling down the decoding and rendering computations to the available processing power, while maximizing the overall perceived quality. This process is applied in a real-time three-dimensional (3-D) decoding and rendering engine, exploiting scalable MPEG-4 coding algorithms. We derive a relation between the quality of the 3-D rendered objects and their processing requirements, expressed by simple CPU time models. The performance dependency parameters are in direct relation to the high-level 3-D content characteristics (number of triangles, number of rendered screen pixels per object) and are calibrated for the platform under test. Examples show that, for any pre-established frame rate, the platform workload can reliably be anticipated for adjusting the content and process parameters accordingly.
In‐plane compression of constrained preforms (2001)

Abstract Preforms constructed from a plain‐weave, glass fabric were compressed in‐plane within a fixture that mimicked the constraints of a closed mold. Typically, a gap was left between the bottom of the preform and the floor of the fixture; upon Initial compression, the preform slid within the fixture, which allowed the friction between the preform and the fixture wall to be measured. The preform began to compress as it contacted the floor of the fixture. The deformation was proportional to the applied stress until a critical stress was reached. Above this stress, the preform sustained damage in the form if localized buckling and a corresponding decrease in mechanical integrity. The in‐plane compressive behavior varied with system parameters, such as preform geometry, fabric orientation, and clamping stress and was shown to be strongly dependent on friction of the preform against the fixture wall. A model was developed to describe the contribution of preform friction with the fixture wall to the in‐plane compressive behavior of constrained preforms.
Prior-Independent Mechanisms for Scheduling (2013)

We study the makespan minimization problem with unrelated selfish machines under the assumption that job sizes are stochastic. We design simple truthful mechanisms that under various distributional assumptions provide constant and sublogarithmic approximations to expected makespan. Our mechanisms are prior-independent in that they do not rely on knowledge of the job size distributions. Prior-independent approximation mechanisms have been previously studied for the objective of revenue maximization [Dhangwatnotai, Roughgarden and Yan'10, Devanur, Hartline, Karlin and Nguyen'11, Roughgarden, Talgam-Cohen and Yan'12]. In contrast to our results, in prior-free settings no truthful anonymous deterministic mechanism for the makespan objective can provide a sublinear approximation [Ashlagi, Dobzinski and Lavi'09].
System issues in the implementation of sensory neural network photodetector arrays (2002)

System-level design considerations are described that are necessary for extracting useful signal preprocessing functions from sparsely-interconnected photodetector arrays. Particular emphasis is placed upon the monolithic implementation of such neural networks with focal plane imaging arrays. The most promising fabrication technologies and system architectures are described for a number of neural network implementations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>