gebhart/patrepeval huggingface dataset:
Correlation between serum uric acid and renal function in diabetes with normalbuminuria (2020)

Background: Diabetes mellitus (DM) is one of the most prevalent health issues worldwide. The present study was conducted to assess correlation between serum uric acid and renal function in diabetes with normalbuminuria. Materials & Methods: The present study was conducted on 256 diabetic patients of both genders. The level of urinary creatinine was assayed using the same method as that for serum creatinine. Evaluation of GFR (eGFR) was done according to the CKD-EPI formula. Results: out of 256 patients, males were 146 and females were 110. Out of 146 males, 30 males and out of 110 females, 22 females had hyperuricemia. The mean BMI (kg/m2) in group I was 24.1, in group II was 24.3, in group III was 25.1 and group IV was 25.4. Mena FBG (mmol/L) in group I was 8.6, in group II was 7.5, in group III was 7.4 and in group IV was 7.1, Mean urine pH was 5.9 in group I, 5.7 in group II, 5.6 in group III and 5.1 in group IV, Mean UACR in group I was 10.8 in group I, 9.02 in group II, 9.08 in group III and 10.2 in group IV. Mean eGFR (ml/min/1.73m2) in group I was 89.2, in group II was 85.3, in group III was 82.5 and in group IV was 79.4. The difference was significant (P< 0.05). A correlation of FBG (mmol/L), urine pH, SUA (µmol/L) and UACR with eGFR was found. Conclusion: Authors suggested that hyperuricemia should be controlled efficiently to prevent the GFR decrease and protect the renal function in these patients.
Control of SO/sub 2/ emissions by dry scrubbing (1980)

The dry scrubbing process has been studied with the intent of discriminating the mechanisms and parameters that influence SO/sub 2/ removal. Sulfur dioxide absorption into drying lime droplets is thought to occur during three reaction periods: the constant rate evaporation period, the falling rate evaporation period, and the equilibrium moisture period. 6 refs.
Fe-chitosan complexes for oxidative degradation of emerging contaminants in water: Structure, activity, and reaction mechanism (2020)

Versatile and ecofriendly methods to perform oxidations at near-neutral pH are of crucial importance for processes aimed at purifying water. Chitosan, a deacetylated form of chitin, is a promising starting material owing to its biocompatibility and ability to form stable films and complexes with metals. Here, we report a novel chitosan-based organometallic complex that was tested both as homogeneous and heterogeneous catalyst in the degradation of contaminants of emerging concern in water. The stoichiometry of the complex was experimentally verified with different metals, namely, Cu(II), Fe(III), Fe(II), Co(II), Pd(II), and Mn(II), and we identified the chitosan-Fe(III) complex as the most efficient catalyst. This complex effectively degraded phenol, triclosan, and 3-chlorophenol in the presence of hydrogen peroxide. A putative ferryl-mediated reaction mechanism is proposed based on experimental data, density functional theory calculations, and kinetic modeling. Finally, a film of the chitosan-Fe(III) complex was synthesized and proven a promising supported heterogeneous catalyst for water purification.
Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity (2013)

B cell receptor (BCR) signalling determines B cell differentiation and may potentially alter T cell-mediated immune responses. In this study we used two transgenic strains of BCR-deficient mice expressing Epstein-Barr virus latent membrane protein (LMP)2A in B cells, where either follicular and marginal zone differentiation (D(H)LMP2A mice) or B-1 cell development (V(H)LMP2A mice) were supported, and evaluated the effects of skewed B lymphocyte differentiation on lymphoid organogenesis and T cell responses in vivo. Compared to wild-type animals, both transgenic strains displayed alterations in the composition of lymphoid organs and in the dynamics of distinct immune cell subsets following immunization with the self-antigen PLP₁₈₅₋₂₀₆. However, ex-vivo T cell proliferation to PLP₁₈₅₋₂₀₆ peptide measured in immunized D(H)LMP2A and V(H)LMP2A mice was similar to that detected in immunized control mice. Further, clinical expression of experimental autoimmune encephalitis in both LMP2A strains was identical to that of wild-type mice. In conclusion, mice with skewed B cell differentiation driven by LMP2A expression in BCR-negative B cells do not show changes in the development of a T cell mediated disease model of autoimmunity, suggesting that compensatory mechanisms support the generation of T cell responses.
Discovery of HIV-1 Protease Inhibitors with Picomolar Affinities Incorporating N-Aryl-oxazolidinone-5-carboxamides as Novel P2 Ligands (2006)

Here, we describe the design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors incorporating N-phenyloxazolidinone-5-carboxamides into the (hydroxyethylamino)sulfonamide scaffold as P2 ligands. Series of inhibitors with variations at the P2 phenyloxazolidinone and the P2' phenylsulfonamide moieties were synthesized. Compounds with the (S)-enantiomer of substituted phenyloxazolidinones at P2 show highly potent inhibitory activities against HIV-1 protease. The inhibitors possessing 3-acetyl, 4-acetyl, and 3-trifluoromethyl groups at the phenyl ring of the oxazolidinone fragment are the most potent in each series, with K(i) values in the low picomolar (pM) range. The electron-donating groups 4-methoxy and 1,3-dioxolane are preferred at P2' phenyl ring, as compounds with other substitutions show lower binding affinities. Attempts to replace the isobutyl group at P1' with small cyclic moieties caused significant loss of affinities in the resulting compounds. Crystal structure analysis of the two most potent inhibitors in complex with the HIV-1 protease provided valuable information on the interactions between the inhibitor and the protease enzyme. In both inhibitor - enzyme complexes, the carbonyl group of the oxazolidinone ring makes hydrogenbond interactions with relatively conserved Asp29 residue of the protease. Potent inhibitors from each series incorporating various phenyloxazolidinone based P2 ligands were selected and their activities against a panel of multidrug-resistant (MDR) protease variants were determined. Interestingly, the most potent protease inhibitor starts out with extremely tight affinity for the wild-type enzyme (K(i) = 0.8 pM), and even against the MDR variants it retains picomolar to low nanomolar K(i), which is highly comparable with the best FDA-approved protease inhibitors.
ChemInform Abstract: Synthesis and Properties of Crown Ether‐Modified Phosphines and Their Use as Ligands in Transition Metal Catalysts. (1988)

Abstract The dibenzo crown ethers (I) are treated with the dioxane bromine complex to form the monobrominated derivatives (II).
Personalized Oncology Through Integrative High-Throughput Sequencing: A Pilot Study (2011)

Individual cancers harbor a set of genetic aberrations that can be informative for identifying rational therapies currently available or in clinical trials. We implemented a pilot study to explore the practical challenges of applying high-throughput sequencing in clinical oncology. We enrolled patients with advanced or refractory cancer who were eligible for clinical trials. For each patient, we performed whole-genome sequencing of the tumor, targeted whole-exome sequencing of tumor and normal DNA, and transcriptome sequencing (RNA-Seq) of the tumor to identify potentially informative mutations in a clinically relevant time frame of 3 to 4 weeks. With this approach, we detected several classes of cancer mutations including structural rearrangements, copy number alterations, point mutations, and gene expression alterations. A multidisciplinary Sequencing Tumor Board (STB) deliberated on the clinical interpretation of the sequencing results obtained. We tested our sequencing strategy on human prostate cancer xenografts. Next, we enrolled two patients into the clinical protocol and were able to review the results at our STB within 24 days of biopsy. The first patient had metastatic colorectal cancer in which we identified somatic point mutations in NRAS, TP53, AURKA, FAS, and MYH11, plus amplification and overexpression of cyclin-dependent kinase 8 (CDK8). The second patient had malignant melanoma, in which we identified a somatic point mutation in HRAS and a structural rearrangement affecting CDKN2C. The STB identified the CDK8 amplification and Ras mutation as providing a rationale for clinical trials with CDK inhibitors or MEK (mitogen-activated or extracellular signal-regulated protein kinase kinase) and PI3K (phosphatidylinositol 3-kinase) inhibitors, respectively. Integrative high-throughput sequencing of patients with advanced cancer generates a comprehensive, individual mutational landscape to facilitate biomarker-driven clinical trials in oncology.
Abstract B13: Automated multiplex assay for diagnostic application of contextual microRNA signatures in breast cancer (2012)

Abstract MicroRNAs (miRNAs) are rapidly emerging as a novel class of biomarkers for theranostic applications in cancer. Since solid tumor lesions are complex and heterogeneous mixtures of different cell types, we previously developed a multiplex tissue slide-based assay to measure miRNA expression levels at single cell resolution and to extract the contextual information embedded within both cancer and non-cancer cell compartments of the tumor microenvironment. In this on-going clinical study, we are characterizing the cell type-specific altered expression of a panel of breast cancer-associated miRNAs on large and independent cohorts of breast cancer patients. To maximize the number of independent patient cases per slide and to minimize the number of independent experiments and slides for data analysis, we are interrogating miRNA expression on high-density tissue microarrays (TMAs). TMAs designed by NCI Cooperative Breast Cancer Tissue Resources to find statistically significant associations between an investigative biomarker and disease progression and/or disease outcome will serve as discovery set. Our institutional TMAs will serve as validation set and will also enable us to assess the potential utility of these miRNA contextual signatures to predict treatment response in different adjuvant and neoadjuvant therapy settings using recurrence-free survival and complete pathological response, respectively, as the clinical endpoint marker. Our preliminary results indicate that inflammation and desmoplasia present as co-diseases or co-morbidities in breast cancer, and they are both major confounding factors in the correct interpretation of expression profiling experiments and the assignment of etiological roles to leukocyte-expressed miRNAs such as miR-155 and reactive fibroblast-expressed miRNAs such as miR-21. Intriguingly, we have identified a subgroup of HER2-overexpressing cases in which miR-21 expression is mainly upregulated with cancer cells, while miR-21 expression predominantly accumulates within reactive fibroblasts in the rest of HER2-overexpresssing cases and the immense majority of cases from other breast cancer subtypes. The clinical implications of cell source and expression levels of miR-21 and other miRNAs under study will be presented at this meeting. We will also discuss innovative strategies that we are implementing for integration of translational miRNA and well-established protein biomarkers to increase molecular characterization of breast tumors and for pipeline automatization from assay performance to whole slide image acquisition and computer-assisted analysis to enhance diagnostic power of current clinical assays. Citation Format: Wendy Wells, Sung-hee Choi, Gary Schwartz, Lorenzo F. Sempere. Automated multiplex assay for diagnostic application of contextual microRNA signatures in breast cancer [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer; 2012 Jan 8-11; Miami Beach, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(2 Suppl):Abstract nr B13.
Numerical Methods for Model-Based Pose Recovery (1997)

Whether nonaneurysmal vascular compression of the oculomotor nerve is a true cause of ONP is sometimes controversial. However, recent developments in magnetic resonance imaging can clearly demonstrate the spatial relationship between the oculomotor nerve and vessels. Detailed magnetic resonance imaging should be used to diagnose compression of the oculomotor nerve by blood vessels. Microvascular decompression is the treatment of choice in this situation.
Characterization of nitrogeneous compounds in distillates derived from two-stage coal liquefaction (1994)

The nitrogen compounds in coal distillates have not been characterized as fully as the predominant hydrocarbon components, but are of considerable importance due to their adverse effect on fuel stability and catalyst lifetime and the potentially adverse health and environmental impact. A number of different classes of nitrogen compounds are commonly found in coal liquids (e.g. quinolines, indoles, carbazoles). These each will affect catalyst deactivation and product stability to different extents. This report specifically addresses the nature of nitrogen compounds found in Wilsonville streams. In the current study, gas chromatography with a nitrogen-selective detector (GC/N) and gas chromatography/mass spectrometric (GC/MS) techniques were employed to identify and quantitate the major nitrogen-containing components found in concentrates prepared from coal-derived distillates from two series of Wilsonville pilot plant runs. These runs were made with Illinois No. 6 and Wyodak Coals. While direct GC/N analysis can be done on the whole, untreated distillate, the nitrogen detector is a poor identification tool. Therefore, GC/MS was necessary for compound identification. Consequently, pretreatment of the distillates to obtain N-rich fractions was a necessary step to minimize hydrocarbon interference in GC/MS analyses and allow more detailed examination of the nitrogen components in coal distillates. However, once a typicalmore » nitrogen profile has been characterized, GC/N should allow rapid quantitation of the nitrogen compounds in an untreated distillate.« less
A Hybrid Tabu Search Heuristic for the Two-Stage Assembly Scheduling Problem (2006)

AbstractIn this paper, we address the two-stage assembly scheduling problem where there are m machines at the first stage and an assembly machine at the second stage. The objective is to schedule the jobs on the machines so that total completion time of all n jobs is minimized. Optimal solutions are obtained for two special cases. A simulated annealing heuristic, a tabu search heuristic, and a hybrid tabu search heuristic are proposed for the general case. The proposed heuristics are compared with the existing heuristics and shown to be more efficient. The computational analysis shows that the proposed hybrid tabu search heuristic improves the error rate by about 60 and 90 percent over tabu search and simulated annealing heuristics, respectively, where the CPU time of all the three heuristics is almost the same.
Refractory human papillomavirus-associated oral warts treated topically with 1-3% cidofovir solutions in human immunodeficiency virus type 1-infected patients (2005)

Journal Article Refractory human papillomavirus‐associated oral warts treated topically with 1–3% cidofovir solutions in human immunodeficiency virus type 1‐infected patients Get access R. Husak, R. Husak Departments of Dermatology, Pharmacy and Search for other works by this author on: Oxford Academic Google Scholar C.C. Zouboulis, C.C. Zouboulis Departments of Dermatology, Pharmacy and Search for other works by this author on: Oxford Academic Google Scholar C. Sander‐Bähr, C. Sander‐Bähr Departments of Dermatology, Pharmacy and Search for other works by this author on: Oxford Academic Google Scholar M. Hummel, M. Hummel Pathology, Charité Campus Benjamin Franklin, Fabeckstr. 60–62, 14195 Berlin, Germany E‐mail: ralf.husak@charite.de Search for other works by this author on: Oxford Academic Google Scholar C.E. Orfanos C.E. Orfanos Departments of Dermatology, Pharmacy and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 3, 1 March 2005, Pages 590–591, https://doi.org/10.1111/j.1365-2133.2005.06461.x Published: 01 March 2005
LSI-based amperometric sensor for bio-imaging and multi-point biosensing (2012)

We have developed an LSI-based amperometric sensor called "Bio-LSI" with 400 measurement points as a platform for electrochemical bio-imaging and multi-point biosensing. The system is comprised of a 10.4 mm × 10.4 mm CMOS sensor chip with 20 × 20 unit cells, an external circuit box, a control unit for data acquisition, and a DC power box. Each unit cell of the chip contains an operational amplifier with a switched-capacitor type I-V converter for in-pixel signal amplification. We successfully realized a wide dynamic range from ±1 pA to ±100 nA with a well-organized circuit design and operating software. In particular, in-pixel signal amplification and an original program to control the signal read-out contribute to the lower detection limit and wide detection range of Bio-LSI. The spacial resolution is 250 μm and the temporal resolution is 18-125 ms/400 points, which depends on the desired current detection range. The coefficient of variance of the current for 400 points is within 5%. We also demonstrated the real-time imaging of a biological molecule using Bio-LSI. The LSI coated with an Os-HRP film was successfully applied to the monitoring of the changes of hydrogen peroxide concentration in a flow. The Os-HRP-coated LSI was spotted with glucose oxidase and used for bioelectrochemical imaging of the glucose oxidase (GOx)-catalyzed oxidation of glucose. Bio-LSI is a promising platform for a wide range of analytical fields, including diagnostics, environmental measurements and basic biochemistry.
Impulse Response of a Waveguide Subject to Mode Conversion-Reconversion (1980)

The paper presents a simple derivation of the impulse response of an overmoded circular waveguide carrying an H01 mode. It is assumed that rate of coupling between the H01 mode and the parasitic modes is small otherwise the coupling can be systematic (e.g. periodic) or random with a given power density spectrum (PDS). In the latter case the method gives an expression for the statistically expected impulse response. The results can be used subsequently, through the medium of convolution, to predict distortion of, for example, digital signals.
Optimum receiver filter for a noise-based frequency-offset modulation system (2016)

A frequency-offset transmit-reference (TR) system using a noise carrier is considered in additive white Gaussian noise. The system is studied for any given spectrum of the noise carrier, and the expression for the transfer function of an optimal receiver front-end filter is derived. The maximum achievable performance with respect to spectral shape is evaluated and discussed. The results indicate that the optimal filter in this system, unlike in traditional wireless systems, needs dynamic adaptation to the received signal and noise levels. A convenient but suboptimal choice of the filter is also suggested, and the achievable performance is compared with that of an optimal filter and a performance upper bound. For a certain spectral shape, the suboptimal filter is shown to be an overall good compromise. To meet the performance upper bound, a system using the suboptimal filter, and a noise carrier shaped by a Butterworth filter of order 1, faces a power penalty of 1.89 dB.
Postulates of Quantum Mechanics (2014)

A postulate is an idea that is suggested as, or assumed to be, the basis for a theory, argument or calculation. In quantum mechanics, the postulates concern the atomic and molecular properties, which are quite far removed from everyday experience. Consequently, in this regard, these may be difficult to understand. The important point is that the postulates are justified by their ability to predict. They should also have the ability to correlate experimental facts by their general applicability.
GaN Microwave DC–DC Converters (2015)

This paper presents the design and characterization of dc-dc converters operating at microwave frequencies. The converters are based on GaN transistor class-E power amplifiers (PAs) and rectifiers. Three topologies are presented, which are: 1) a PA and synchronous rectifier, requiring two RF inputs; 2) a PA and self-synchronous rectifier with a single RF input; and 3) a power oscillator with a self-synchronous rectifier with no required RF inputs. The synchronous 1.2-GHz class- E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> converter reaches a maximum efficiency of 72% at 4.6 W. By replacing the RF input at the rectifier gate with a specific termination, a self-synchronous circuit demonstrates 75% efficiency at 4.6 W, with a maximum output power of 13 W at 58% efficiency. In the third topology, the PA is replaced by a power oscillator by providing correct feedback for class-E operation, resulting in a circuit requiring no RF inputs. This oscillating self-synchronous dc-dc converter is demonstrated at 900 MHz with an efficiency of 79% at 28 V and 12.8-W output power. Self-synchronous class-E transistor rectifier operation is analyzed theoretically in the time domain and validated with harmonic-balance simulations using an improved nonlinear model for a GaN HEMT. The simplified theoretical analysis provides a useful starting point for high-efficiency self-synchronous power rectifier design, which can, in turn, be extended to high-efficiency oscillating power inverter design.
Further Evidence of Collimated X-Ray Emission from CuSO_4 Doped Gelatin (1973)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text R. C. Elton, L. J. Palumbo, R. A. Andrews, R. C. Eckardt, and J. N. Bradford, "Further Evidence of Collimated X-Ray Emission from CuSO4 Doped Gelatin," Appl. Opt. 12, 155-155 (1973) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article