gebhart/patrepeval huggingface dataset:
Validation of a semi-automatic coregistration of MRI scans in brain tumor patients during treatment follow-up (2016)

This research was funded by a National Institute of Health Clinician Scientist Fellowship [SJP], a Remmert Adriaan Laan Fund [AH], a Rene Vogels Fund [AH] and a grant from the Chang Gung Medical Foundation and Chang Gung Memorial Hospital, Keelung [JLY]. None of the authors have financial of other conflict of interest related to the work presented in this paper. This paper presents independent research funded by the UK National Institute for Health Research (NIHR). The views expressed are those of the author(s) and not necessarily those of the UK NHS, the UK NIHR or the UK Department of Health.
Development of a novel carbon nanotube based printed and flexible pressure sensor (2017)

A flexible carbon nanotube (CNT) based capacitive pressure sensor was developed for the detection of varying applied pressures. The sensor was successfully fabricated using the screen printing technique. Polydimethylsiloxane (PDMS) was used as a dielectric layer and it was prepared using a PDMS pre-polymer and a curing agent mixed in a 10:1 ratio. The electrode was directly screen printed using conductive CNT ink onto the PDMS. The capability of the sensor to distinguish between varying applied pressures were investigated based on its capacitive response. It was observed that the CNT-based pressure sensor produced an 8.2% change in capacitance when compared to the base capacitance, for a maximum detectable pressure of 337 kPa. A 0.021% change in capacitance per kPa and a correlation coefficient of 0.9971 was also determined for the CNT-based pressure sensor. The capacitive response of the printed sensor demonstrated the feasibility of employing CNT-based electrodes for the development of efficient, flexible and cost-effective pressure sensors for sports, military, robotic, automotive and biomedical applications.
Some mathematical properties of cayley digraphs with applications to interconnection network design (2005)

We consider the relationships between Cayley digraphs and their coset graphs with respect to subgroups and obtain some general results on homomorphism and broadcasting between them. We also derive a general factorization theorem on subgraphs of Cayley digraphs by their automorphism groups. We discuss the applications of these results to well-known interconnection networks such as the butterfly network, the de Bruijn network, the cube-connected cycles network and the shuffle-exchange network.
Radiofrequency ablation of atrioventricular nodal reentrant tachycardia: the risk of intraprocedural, late and long-term atrioventricular block. The Veneto Region multicenter experience. (2002)

The risk of permanent AV block in patients who undergo fast or slow pathway ablation is low and limited to the procedure or to the days immediately after the procedure, and there is no risk of II-III degree AV block during long-term follow-up.
Proximal pulmonary artery blood flow characteristics in healthy subjects measured in an upright posture using MRI: The effects of exercise and age (2005)

It appears that at both rest and during exercise, in children and adults alike, RPA/LPA mean blood flow distribution is predominantly determined by distal vascular resistance, while retrograde flow is affected by proximal pulmonary bifurcation geometry.
Machine Learning Surrogates for Predicting Response of an Aero-Structural-Sloshing System (2019)

This study demonstrates the feasibility of developing machine learning (ML) surrogates based on Recurrent Neural Networks (RNN) for predicting the unsteady aeroelastic response of transonic pitching and plunging wing-fuel tank sloshing system by considering an approximate simplified model of an airfoil in transonic flow and sloshing loads from a partially filled fuel tank rigidly embedded inside the airfoil and undergoing a free unsteady motion. The ML surrogates are then used to predict the aeroelastic response of the coupled system. The external aerodynamic loads on the airfoil and the two-phase sloshing loads data for training the RNN are generated using open-source computational fluid dynamics (CFD) codes. The aerodynamic force and moment coefficients are predicted from the surrogate model based on its motion history. Similarly, the lateral and vertical forces and moments from fuel sloshing in the fuel tank are predicted using the surrogate model resulting from the motion of the embedded fuel tank. Comparing the free motion of the airfoil without sloshing tank to the free motion of the airfoil with a partially-filled fuel tank shows that the effects of sloshing on the aeroelastic motion of the aero-structural system. The effectiveness of the predictions from RNN are then assessed by comparing with the results from the high-fidelity coupled aero-structural-fuel tank sloshing simulations. It is demonstrated that the surrogate models can accurately and economically predict the coupled aero-structural motion.
3D Gated Recurrent Fusion for Semantic Scene Completion (2020)

This paper tackles the problem of data fusion in the semantic scene completion (SSC) task, which can simultaneously deal with semantic labeling and scene completion. RGB images contain texture details of the object(s) which are vital for semantic scene understanding. Meanwhile, depth images capture geometric clues of high relevance for shape completion. Using both RGB and depth images can further boost the accuracy of SSC over employing one modality in isolation. We propose a 3D gated recurrent fusion network (GRFNet), which learns to adaptively select and fuse the relevant information from depth and RGB by making use of the gate and memory modules. Based on the single-stage fusion, we further propose a multi-stage fusion strategy, which could model the correlations among different stages within the network. Extensive experiments on two benchmark datasets demonstrate the superior performance and the effectiveness of the proposed GRFNet for data fusion in SSC. Code will be made available.
Detection of Plant Pathogen Using LPNE Grown Single Conducting Polymer Nanoribbon (2010)

Abstract not Available.
Lung Clearance Index bei Patienten mit obstruktiven Ventilationsstörungen (2016)

Hintergrund: Die Beurteilung obstruktiver Ventilationsstörungen erfolgt bislang an Hand spirometrischer und bodyplethysmographischer Parameter. Diese bilden jedoch die periphere Obstruktion – als wichtige pathophysiologische Komponente vieler Erkrankungen – nur unzureichend ab. Die Impulsoszillometrie (IOS) lieferte vielversprechende Ergebnisse bei der Beurteilung der peripheren Atemwegswiderstände. Wichtige Informationen bezüglich Ventilationsinhomogenitäten könnten mittels Multiple Breath Washout (MBW) gewonnen und im Lung Clearance Index (LCI) abgebildet werden. Er ist im pädiatrischen Bereich für die cystische Fibrose etabliert, für adulte Kollektive liegen jedoch nur wenige Daten vor. Ziel der Arbeit war der Vergleich der konventionellen Lungenfunktionsdiagnostik und IOS mit MBW bei Patienten mit Obstruktion.
A NOVEL TECHNIQUE FOR ASSESSING LOAD-DEPENDENT CARDIAC FUNCTION DURING LVAD SUPPORT USING TELEMETERED LEFT VENTRICULAR PRESSURE (2005)

Strategies have not been developed for the repetitive assessment of LV function during VAD support using only LV pressure (LVP). Methods: In Suffolk sheep (N=3) an axial flow VAD, telemetered LVP monitor, outflow graft flow probe and LV long/short axis sonometric crystals were placed. In awake sheep, VAD speed was acutely increased from 6,000 to 11,000 rpm (“run”) as load-dependent LV function was assessed by preload recruitable stroke work (slope:Mw) before and after esmolol. Simultaneously, LV Triple Product (LVTP) was calculated and the slope (MTP) of LVTP vs LVEDP was also derived. Results: VAD support, 3.9±0.40L/m, was maintained for 18±5 days. During VAD “run”, VAD flow increased (0.96±0.22 to 4.8±0.55L/m) while LV stroke work (3101±107 to 1860±462 ml*mmHg), TP (3297±581 to 1068±743 #/10 5) and LVEDP (19.7±2.0 to 9.6±1.9 mmHg) were decreased (P<0.01). MTPand the MW established during VAD “run” were reduced by esmolol (see figure, *P<0.05).FigureConclusion: The slope of LVTP vs LVEDP, MTP, derived during VAD flow adjustment may provide an index of load-dependent LV function during VAD support in patients with a LVP monitor.
Representing clinical questions by semantic type for better classification. (2006)

It is recognized that physicians need information that answers their questions at the point of care. Taxonomic classification of clinical domain questions is a preliminary step in developing real-time answer retrieval systems. We show that using the UMLS semantic types and machine learning algorithms improves classification performance of clinical questions for the generic taxonomic categories.
Anthrax Edema Toxin Inhibits Endothelial Cell Chemotaxis via Epac and Rap1 (2007)

Angiogenesis involves the assembly of endothelial cells into capillaries from a pre-existing vasculature. Because abnormal angiogenesis is a hallmark of many cancers, it is critical to find factors that control this process. Endothelial cells are enriched in the anthrax receptor; we therefore determined the effect of anthrax edema toxin (ET), an adenylyl cyclase, on chemotaxis. cAMP generated by ET does not block proliferation or survival but causes cytoskeletal changes and inhibits chemotaxis by primary human microvascular endothelial cells (HMVECs). These effects are due to the action of a downstream cAMP effector, Epac, a guanine nucleotide exchange-activating protein for Rap1 (RAP1-GEF). ET induces transcription of Epac-related activators of Rap1, Epac2 (RapGEF4), and MR-GEF/RapGEF5. Similar to ET, activated Epac or Rap1 induces cytoskeletal changes and blocks chemotaxis in human endothelial cells. These results identify Epac and Rap1 as key regulators of signaling cascades leading to endothelial cell chemotaxis.
A Tale about Tau (2007)

Diminished levels of the tau protein seem to protect mice from the development of behavioral abnormalities and memory loss that are brought about by mutant amyloid precursor protein.
Identification of Autophosphorylation Inhibitors of the Inositol-Requiring Enzyme 1 Alpha (IRE1α) by High-Throughput Screening Using a DELFIA Assay (2012)

Inositol-requiring enzyme 1 alpha (IRE1α) is a transmembrane sensor protein with both kinase and ribonuclease activity, which plays a crucial role in the unfolded protein response (UPR). Protein misfolding in the endoplasmic reticulum (ER) lumen triggers dimerization and subsequent trans-autophosphorylation of IRE1α. This leads to the activation of its endoribonuclease (RNase) domain and splicing of the mRNA of the transcriptional activator XBP1, ultimately generating an active XBP1 (XBP1s) implicated in multiple myeloma survival. Previously, we have identified human IRE1α as a target for the development of kinase inhibitors that could modulate the UPR in human cells, which has particular relevance for multiple myeloma and other secretory malignancies. Here we describe the development and validation of a 384-well high-throughput screening assay using DELFIA technology that is specific for IRE1α autophosphorylation. Using this format, a focused library of 2312 potential kinase inhibitors was screened, and several novel IRE1α kinase inhibitor scaffolds were identified that could potentially be developed toward new therapies to treat multiple myeloma.
Microwave-accelerated Suzuki cross-coupling reaction in polyethylene glycol (PEG) (2001)

Polyethylene glycol (PEG) is found to be an inexpensive and non-toxic reaction medium for the microwave-assisted Suzuki cross-coupling of arylboronic acids with aryl halides. This environmentally friendly microwave protocol offers ease of operation and enables recyclability of catalyst and synthesis of a variety of substituted biaryls employing palladium chloride as catalyst and potassium fluoride as the base.
Self‐Assembly or Coassembly of Multiresponsive Histidine‐Containing Elastin‐Like Polypeptide Block Copolymers (2021)

In this study a histidine containing elastin-like polypeptide (ELP) diblock copolymer is described with multiresponsive assembly behavior. Self-assembly into micelles is examined by two methods. First, the self-assembly is triggered by the addition of divalent metal ions, with Zn<sup>2+</sup> being the most suitable one. Increasing the Zn<sup>2+</sup> concentration stabilizes the nanoparticles over a large temperature window (4-45 °C). This diblock exhibits furthermore pH-responsiveness, and particles disassemble under mildly acidic conditions. Second, the coassembly of this ELP with a diblock ELP is examined, which is not responsive to pH and metal ions. Coassembly is triggered by heating the ELPs quickly above the transition temperature of the less hydrophobic block, which results in stable nanoparticles without the need to add metal ions. This novel ELP system offers a versatile modular nanocarrier platform that can respond to different stimuli and can be tuned effectively.
Interwoven spiral arrays on ferrite-dielectric substrates for high-impedance metasurfaces (2014)

International audience
Noise Reduction Method for Image Compression Using ICA (1997)

In recent years, many methods for image compression have been proposed. Especially, JPEG and MPEG have achieved high compression ratio while these can not recover the original images completely. In these methods, image data are reduced in spatial frequency domain according to a human eye property. In this study, we have developed a new method to reduce image data with noise components in the image using an Independent Component Analysis (ICA). An advantage of this method is to preserve quality of the image by reducing the noise which is independent of the original image data.
Voltage-activated sodium currents in acutely isolated mouse vestibular ganglion neurones (1997)

Voltage-activated sodium currents (INa) in vestibular ganglion neurones acutely isolated from postnatal mice were investigated using the whole-cell configuration of the patch-clamp technique. Under recording conditions designed to allow the complete isolation of INa depolarizations from a holding potential of -80 mV revealed a fast inactivating inward current which was activated around -60 mV and exhibited maximum peak current around -30 mV. This current was eliminated when the cells were perifused with a Na(+)-free solution and almost totally blocked by application of 100 nM tetrodotoxin (TTX). These properties identify this inward current as TTX-sensitive INa. The half-maximum activation potential of INa was -46 mV and its half-maximum inactivation potential was -69 mV. This is the first report of voltage-activated sodium currents in vestibular primary neurones.
Hydrocortisone suppresses the generation of nonspecific "anomalous" killers but not specific cytolytic T lymphocytes in human mixed lymphocyte-tumor cultures. (1984)

Abstract Interpretation of results with the use of effector populations generated in human mixed lymphocyte tumor cultures (MLTC) has in many cases been clouded by the presence of two distinct cytolytic effectors: specific cytolytic T lymphocytes (CTL) and nonspecific anomalous killers (AK). The addition of 5 to 50 X 10(-6) M hydrocortisone sodium succinate (HC) to "three-cell" allogeneic human MLTC containing responder lymphocytes, irradiated allogeneic glioma cells, and irradiated third-party stimulator lymphocytes consistently reduced the generation of AK by greater than 90% while having little or no effect on the generation of CTL specific for antigens present on the glioma cells. HC was similarly effective in blocking the generation of AK when added to cultures of responder cells incubated with lymphokine-containing supernatants from mixed lymphocyte cultures. Kinetic experiments indicated that HC both decreased the initial rate of appearance of AK activity and subsequently caused the AK response to decline more rapidly. HC had only a small inhibitory effect on the lytic action of AK generated in its absence. The ability of HC to suppress strongly the generation of nonspecific but not specific cytolytic effectors suggests that nonspecific AK are not polyclonally activated CTL or CTL at an early stage of differentiation, but rather represent a distinct cytolytic effector system. The inclusion of HC in human MLTC may provide a useful tool for distinguishing between lysis due to the generation of specific CTL and lysis due to the generation of nonspecific AK.
Improved maximum entropy method for the analysis of fluorescence spectroscopy data: evaluating zero-time shift and assessing its effect on the determination of fluorescence lifetimes (2015)

A new algorithm based on the Maximum Entropy Method (MEM) is proposed for recovering both the lifetime distribution and the zero-time shift from time-resolved fluorescence decay intensities. The developed algorithm allows the analysis of complex time decays through an iterative scheme based on entropy maximization and the Brent method to determine the minimum of the reduced chi-squared value as a function of the zero-time shift. The accuracy of this algorithm has been assessed through comparisons with simulated fluorescence decays both of multi-exponential and broad lifetime distributions for different values of the zero-time shift. The method is capable of recovering the zero-time shift with an accuracy greater than 0.2% over a time range of 2000 ps. The center and the width of the lifetime distributions are retrieved with relative discrepancies that are lower than 0.1% and 1% for the multi-exponential and continuous lifetime distributions, respectively. The MEM algorithm is experimentally validated by applying the method to fluorescence measurements of the time decays of the flavin adenine dinucleotide (FAD).
ChemInform Abstract: General Synthesis of β,γ‐Alkynylglycine Derivatives. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A family of novel DNA sequencing instruments based on single-photon detection (2002)

We have developed a family of high-performance capillary DNA sequencing instruments based on a novel multicolor fluorescent detection technology. This technology is based on two technical innovations: the multilaser excitation of fluorescence of labeled DNA fragments and the "color-blind" single-photon detection of modulated fluorescence. Our machines employ modern digital and broadband techniques that are essential for achieving superior instrument performance. We discuss the design and testing results for several versions of the automated single lane DNA sequencers, as well as our approach to scaling up to multilane instruments.
A distinctive new species of moss salamander (Caudata: Plethodontidae: Nototriton) from an imperiled Honduran endemism hotspot (2010)

A new species of Nototriton is described from Refugio de Vida Silvestre Texiguat in northern Honduras, and is presented in a new phylogenetic hypothesis for the genus Nototriton. This species differs from all other congeners by a number of morphological characteristics, including but not limited to large nares, syndactylous hands and feet with pointed toe tips, and a pale ventral surface with light mottling. Mitochondrial sequence divergence distinguishes this species from all other Nototriton (3.6–6.0% at 16S and 10.2–15.1% at cytochrome b). Refugio de Vida Silvestre Texiguat harbors a remarkable herpetofauna, including 20% of all endemic amphibian and reptile species in Honduras, among which are five species (one anuran, one lizard, and three snakes) known only from the immediate vicinity of the type locality of the new species. Despite the evolutionary and conservation importance of this reserve, it remains one of the most imperiled cloud forests in Honduras due to persistent illegal logging and forest clearing.
Decoupling a Reflecting Layer From Its Support Structure (1984)

Mounting decouples thermal distortions of reflective surface so not transmitted to support structure. Reflecting layer consists of aluminum reflecting tiles attached to support structure by flexural mounting bend and twist to accommodate thermal expansion of tiles. Technique useful in microwave-antenna reflectors.
Time Reversal techniques applied to wire fault detection and location in wire networks (2012)

In this thesis we present new approaches in the domains of soft fault detection and location in complex wire networks, based on the properties of time reversal. When addressing the detection of soft faults, the idea is to adapt the testing signal to the network under test, instead of being predefined for all the tested networks, as opposed to standard reflectometry techniques. We prove that this approach, which we name the Matched Pulse approach (MP), is beneficial whenever the system is more complex, i.e., its response is richer in echoes, which is opposed to common understanding. The MP analysis is conducted via a formal mathematical analysis, followed by simulation and experimental results validating the proposed approach. In the domain of soft fault location, and based on the DORT (Decomposition de l’Operateur de Retournement Temporel) properties, we derive a distributive non-iterative method able to synthesize signals that focus on the fault position. Through a statistical study we analyze some of the influencing parameters on the performance of the method, and then simulation and experimental results show that the method is able to synthesize signals directly focalizing on the soft fault position, without the need for iterations.
The value of Tablets as reading aids for individuals with central visual field loss: an evaluation of eccentric reading with static and scrolling text (2016)

Our data show that reading performance with scrolling text is at least equal to that achieved with static text and in some respects (reading error rate) is better than static text. Bespoke apps informed by an understanding of the underlying sensorimotor processes involved in a cognitive task such as reading have excellent potential as aids for people with visual impairments.
Study on time lag of void discharge in epoxy resin by considering attenuation of X-ray irradiation dose (2011)

It is crucial for proper insulation design of cast resin transformer to consider voids and delamination which might exist in cast molding process and/or under long-term operation because of several surface boundaries between resin and conductor. Should such defects in the insulation system exist, it would lead to reduction of the life of the apparatus. In this report, we investigate X-ray irradiation induced discharge of spherical void in epoxy resin. Physical consideration of the effect of X-ray irradiation on void discharges in epoxy resin was also made. Time lag of void discharges in epoxy resin was also made with attenuation of X-ray irradiation dose considered.