gebhart/patrepeval huggingface dataset:
Effect of epitaxial temperature on N-polar InN films grown by molecular beam epitaxy (2006)

Effect of growth temperature on 2.3μm thick N-polar InN films grown on GaN template at 440–620°C by plasma-assisted molecular beam epitaxy was investigated. We found different growth behaviors depending on the growth temperatures, which greatly influenced surface morphology. The surface showed dendritic morphologies at temperatures lower than 540°C while step-flow-like morphologies and spiral growth were clearly observed at temperatures higher than 540°C. Crystalline quality was improved with increasing growth temperature up to 540°C and was almost saturated at higher temperatures. A gradual blueshift of the emission peak was observed from 13K photoluminescence (PL) spectra with increasing growth temperature, which was due to the increased compressive strain in InN films. A Poisson ratio (ν=0.21±0.05) for InN and a slope of PL peak energy as a function of εc (δE∕δεc=18.9eV) were obtained. Our results indicated that the epitaxial temperatures of 540–600°C were best to achieve high quality InN films with a smooth surface.
Stem cell factor induces phosphatidylinositol 3′-kinase–dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells (2000)

Stem cell factor (SCF) has an important role in the proliferation, differentiation, survival, and migration of hematopoietic cells. SCF exerts its effects by binding to cKit, a receptor with intrinsic tyrosine kinase activity. Activation of phosphatidylinositol 3′-kinase (PI3-K) by cKit was previously shown to contribute to many SCF-induced cellular responses. Therefore, PI3-K-dependent signaling pathways activated by SCF were investigated. The PI3-K-dependent activation and phosphorylation of the tyrosine kinase Tec and the adapter molecule p62Dok-1 are reported. The study shows that Tec and Dok-1 form a stable complex with Lyn and 2 unidentified phosphoproteins of 56 and 140 kd. Both the Tec homology and the SH2 domain of Tec were identified as being required for the interaction with Dok-1, whereas 2 domains in Dok-1 appeared to mediate the association with Tec. In addition, Tec and Lyn were shown to phosphorylate Dok-1, whereas phosphorylated Dok-1 was demonstrated to bind to the SH2 domains of several signaling molecules activated by SCF, including Abl, CrkL, SHIP, and PLCγ-1, but not those of Vav and Shc. These findings suggest that p62Dok-1 may function as an important scaffold molecule in cKit-mediated signaling.
1603. Comparison of Ceftolozane/Tazobactam, Ceftazidime/Avibactam, and Meropenem/Vaborbactam Activity Against P. aeruginosa: A Multicenter Evaluation (2020)

Abstract Background Recent data have shown high rates of resistance and co-resistance of P. aeruginosa (PsA) to traditional first-line β-lactam antibiotics (piperacillin/tazobactam, ceftazidime, cefepime, and meropenem), with &amp;lt; 45% susceptibility to the others when resistance to one agent is present, driving a large medical need for newer agents. We compared the in vitro activity of newer Gram-negative antibiotics ceftolozane/tazobactam (CT), ceftazidime/avibactam (CA), and meropenem/vaborbactam (MV) against a global collection of PsA isolates. Methods Data were collected from multiple US hospitals as part of the SMART Surveillance Program (2019). Susceptibility testing (MIC, mg/L) was performed by broth microdilution, with susceptibility determined by CLSI breakpoints except for MV where EUCAST breakpoints were applied due to CLSI offering no susceptibility breakpoint criteria. Results 865 clinical P. aeruginosa isolates (one unique initial isolate per patient) were submitted from 21 US medical centers in 2019. 32% were from ICU patients; 71% were from lower respiratory tract infections. The phenotypic β-lactam susceptibility profile in this population was piperacillin/tazobactam (79%), ceftazidime (82%), cefepime (83%), and meropenem (78%). The table provides the comparative susceptibility rates. Co-resistance between commonly prescribed first line β-lactam antibiotics was common. CT, CA and MV were more active than traditional β-lactams, with CT having higher in vitro activity regardless of phenotype, followed by CA and then MV. Table. Probability of Coverage for P. aeruginosa when Non-Susceptibility or Resistance to a Given First Line β-lactam Antibiotic Conclusion To our knowledge, this is the largest multicenter head to head comparison of the activities of ceftolozane/tazobactam, ceftazidime/avibactam and meropenem/vaborbactam among P. aeruginosa with varying resistant phenotypes. Among the newer agents, ceftolozane/tazobactam demonstrated the most reliable in vitro activity against P. aeruginosa with resistance to traditional first-line β-lactams. Further studies are needed to translate the potential clinical relevance of these findings in different practice settings with varying rates of antimicrobial resistance among P. aeruginosa. Disclosures Pamela Moise, PharmD, Merck &amp; Co., Inc. (Employee, Shareholder) C. Andrew DeRyke, PharmD, Merck &amp; Co., Inc. (Employee, Shareholder) Marcela Gonzalez, MD, MSD (Employee, Shareholder) Irina Alekseeva, MD, PhD, MSD (Employee, Shareholder) Diego Lopez, MD, MSD (Employee, Shareholder) Brune Akrich, MD, MSD (Employee, Shareholder) Daniel F. Sahm, PhD, IHMA (Employee)Pfizer, Inc. (Consultant)Shionogi &amp; Co., Ltd. (Independent Contractor) Katherine Young, MS, Merck &amp; Co., Inc. (Employee, Shareholder)Merck &amp; Co., Inc. (Employee, Shareholder) Mary Motyl, PhD, Merck &amp; Co, Inc (Employee, Shareholder)
Detection and quantification of circulating antigen in schistosomiasis by a monoclonal antibody. I. Specificity analysis of a monoclonal antibody with immunodiagnostic capacity. (1986)

Monoclonal antibodies were obtained after immunization of mice with Schistosoma mansoni excretory/secretory antigen, previously shown to contain the circulating cathodic (M) antigen. Among these, the 40:B1 monoclonal antibody proved to be specific for the schistosome genus and to detect only adult worm-derived antigens as shown both by immunoprecipitation and with a two-site immunoradiometric assay using the monoclonal as both the solid-phase and the labelled antibody. The two-site immunoradiometric assay allows a sensitive measurement (detection limit: 5 ng) of circulating schistosome antigen in blood and in urine from patients with schistosomiasis. The amount of circulating schistosome M antigen is correlated with schistosome egg excretion in stool.
Modeling and nonlinear control of shunt active power filter in the synchronous reference frame (2002)

This paper presents a modeling and a nonlinear control of three-phase voltage source shunt active filter. The modeling is based on the abc/dq transformation of the AC system variables. The currents injected by the active filter are controlled in the synchronous orthogonal dq frame using a decoupled nonlinear control strategy. The reference harmonic components are extracted from the sensed nonlinear load currents by applying the synchronous reference frame method, where a three-phase thyristor bridge rectifier with R-L load is taken as the nonlinear load. The voltage level of the DC side is regulated using a linearizing feedback control. The reference current needed to maintain a regulated DC voltage is added to the current loop reference. The transfer functions of the two loops are developed and synthesized to obtain the desired stability and dynamic response. Simulation results confirm the performances considered theoretically for the shunt active filter topology.
Instantaneous Microwave Frequency Measurement Using Programmable Differential Group Delay (DGD) Modules (2010)

We propose and experimentally demonstrate a photonic approach for the measurement of microwave frequencies with adjustable measurement range and resolution. After an unknown microwave signal is modulated onto an optical carrier by a Mach–Zehnder modulator (MZM), the optical output of the MZM is sent to two programmable differential group delay (DGD) modules to introduce different microwave power fading effects, respectively. When the microwave powers of the two channels are measured with two photodetectors separately, a fixed relationship between the microwave power ratio and the microwave frequency is established. The frequency measurement range and resolution can be tuned by electrically varying the DGD values. Frequency measurement with good accuracy for the microwave signals is experimentally realized. When the input power of a continuous-wave microwave signal is within the range of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$-$</tex></formula> 15 to <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$-$</tex></formula> 3 dBm, the measured errors remain within <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\pm$</tex></formula> 0.04 GHz for a measurement range of 4.5–6.5 GHz.
The ′reading man flap′ for pressure sore reconstruction (2011)

The reading man flap was found to be a useful technique for the closure of pressure sore in different anatomic locations. The advantage of tension-free closure and the minimal additional healthy skin excision made this flap a useful tool in pressure sore reconstructions.
Improved Performance of Half-Bridge Series Resonant Inverter for Induction Heating with Discontinuous Mode Control (2007)

In this paper, a study of the Discontinuous current Mode (DM) control applied to a half-bridge series resonant inverter for domestic induction heating is presented. The proposed control is interesting for this application because it exhibits reduced switching losses and the output power control is linear with the switching frequency. Considering that the load is disconnected from the source during part of the switching period, with DM control. A time-domain analysis method is proposed to obtain the analytical expression of the output power, the capacitor voltage and load current. The validity of the analytical expression is checked through simulation. Finally, an experimental comparison of efficiency between traditional controls and the DM control is performed for the induction heating application. In the low power range the efficiency of DM control is higher than traditional schemes.
Resolving factors of inflammation—a bridge between Innate immunity and Adaptive immunity (2013)

Acute inflammation, a physiologic response to protect cells from microbial infection and other stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and can progress to a chronic inflammation such as rheumatoid arthritis, interstitial pneumonitis. To prevent chronic inflammation, understanding the process that resolves inflammation is essential. Resolution of inflammation is an active coordinated process regulated by distinct anti-inflammatory and pro-resolving endogenous lipid mediators, such as lipoxins/ALX, chemerin/chemR23. In resolution of inflammation these resolving factors contribute a bridge between innate and adaptive immunity.
Loading rate effect on mechanical properties of an unsaturated silty sand (2021)

This paper presents the results of an experimental study on the effects of testing rate on stress-strain behavior and volumetric changes of soil. A series of suction-controlled triaxial tests has been performed on reconstituted specimens of a silty sand (SM), at different stress-rates and strain-rates, respectively. The stress-strain paths were applied by using a modified version of a Bishop and Wesley device (USPv2), capable of applying independently pore-water and air pressure at both ends of the soil sample. During the isotropic compression stages loading rates of 2 and 32 kPa/h have been applied under constant suction values of 15 and 45 kPa. The drained deviator stages were conducted at the same suction levels under strain rates of 0.25 and 2.50 %/h. Results are presented in terms of applied loading rates as a function of the specimens specific volume, preconsolidation pressure, soil compressibility and deviatoric stress against strain rate. A comparison of results was made to a former study, under similar testing conditions of suction and loading rates at University of Napoli Federico II. The effect of loading rate on the soil behavior seems to have an insignificant effect on the specific volume variations, for the imposed values during the testing campaign.
Moisture and Fine Forest Fuel Response (1985)

The dynamics of the fine forest fuel's response to moisture changes have not been fully recognized. Fire behavior systems now in use consider all fine fuels to have a 1-hour response time. Experimental results of testing a wide range of fine fuels show the change in moisture content does follow a negative exponential in time. In addition, there is great variability in the desorption and adsorption response times of recently cast and weathered materials. Fuels such as cheatgrass stems and leaves, rockhair lichens, and Cladonia spp. have response times of 1 hour or less. However, other needle fuels such as lodgepole pine, Douglas-fir, and Engelmann spruce have response times greater than 15 hours. Adsorption response times are generally longer than desorption. Weathering for 1 year does shorten response times, but they still remain longer than 1 hour. The effect of a weather diurnal cycle is demonstrated.
Tooth recognition in dental radiographs via Hu's moment invariants (2012)

This paper presents a method to recognize a tooth in dental X-ray images using Hu's moment invariants. The proposed method starts with digitizing dental radiographic films. Next, rectangular bounding boxes of target teeth in the X-ray images are manually specified. The process continues with enhancing the X-ray image with histogram equalization. The teeth are segmented with the assistance of Otsu's method. The next step is to calculate Hu's moment invariants that are used as the teeth's features. Finally, tooth recognition is done by feature matching with Euclidian distance.
Comparative Evaluation of Cytotoxicity and Antioxidative Activity of 20 Flavonoids (2008)

Flavonoids are common dietary components with many health benefits shown through epidemiological studies. However, the fact that flavonoids also act as pro-oxidants and mutagens makes the safety of flavonoids uncertain when used at higher doses. To give a preliminary evaluation on the correlation between beneficial and harmful effects of flavonoids, the antioxidative activity and cytotoxicity of 20 flavonoids from food and herbs were investigated in vitro. The results indicated that luteolin, hydroxygenkwanin, and kaempferol possessed significant dual properties, whereas flavokawain B, flavokawain C, cardamonin, and uvangoletin showed a marked cytotoxicity. The relationships between structure and antioxidant and cytotoxic activity are intensively discussed. In view of the toxicity, the intake of flavonoids in large amounts should not yet be encouraged.
Inorganic Layered Double Hydroxides as Nonviral Vectors (2000)

A biomolecular–inorganic hybrid is formed from anionic biomolecules (such as DNA fragments, ATP, or an antisense oligonucleotide) intercalated in a cationic Mg/Al layered double hydroxide (see picture). Such a hybrid can be used to deliver drugs or genes from the inorganic noncytotoxic carrier. Cellular uptake experiments confirm this, with the carrier dissolving slowly in a leukemia cell, and thereby releasing its growth-inhibiting load.
RAPID INDUCTION OF HETEROGENEOUS ICE NUCLEATION IN A BIOLOGICALLY COMPATIBLE COOLANT. (2011)

Hypothermia is gaining recognition as an important medical treatment. To treat local cases of injury such as stroke, or certain surgical procedures, there is a need to induce local hypothermia. To treat shock or cardiac arrest survivors, there is a need to rapidly induce global hypothermia. Rapid induction of hypothermia has been achieved in animal research, but it has yet to be achieved clinically using a simple, widely practicable method. The clinical need for therapeutic hypothermia represents an engineering opportunity to develop an easy to use coolant that is sterile, biologically compatible, and maximizes coolant heat capacity. Here we present an initial characterization of a prototype platform technology designed to create a sterile, biologically compatible, high heat capacity coolant that has the potential to be used in all of these clinical applications. The coolant is a specially processed micro-particulate ice saline slurry, that can be easily pumped into a patient through surgical tubing, syringes, or minimally invasive surgical instruments. The device induces heterogeneous ice nucleation in a saline stream that has been super-cooled from room temperature to a temperature below the saline freezing point. Currently, the device begins continuous production of ice slurry that contains ~30 % ice by mass within 10 minutes. The nominal ice particle diameter is smaller than 100 μm. This work represents a significant first step toward addressing clinical needs for rapid human cooling.
Detección de daño en materiales compuestos mediante fibra óptica (2011)

En este articulo se explora la aplicacion del PCA (Principal Component Analysis), y mediciones estadisticas T 2 y Q para detectar danos en estructuras fabricadas en materiales compuestos mediante la utilizacion de FBGs (Fiber Bragg Grating). Un modelo PCA es construido usando datos de la estructura sin danos como un estado de referencia. Los defectos en la estructura son simulados causando pequenas delaminaciones entre el panel y el rigidizador. Los datos de diferentes escenarios experimentales para la estructura sin dano y con dano son proyectados en el modelo PCA. Las proyecciones y los indices T 2 y Q son analizadas. Resultados de cada caso son presentados y discutidos demostrando la viabilidad y el potencial de usar esta formulacion en SHM (Structural Health Monitoring)
Recent advances in Toll‐like receptors and anterior uveitis (2012)

Uveitis involves acute, recurrent or chronic inflammation of the uvea, and occurs when the normal state of ocular immune privilege has broken down. Accumulating evidence implicates the role of microbial triggers in the development of various forms of immune-mediated uveitis in addition to its causative role in infectious uveitis. Toll-like receptors (TLRs) are the most important pattern-recognition receptors of the innate immune system that recognize pathogen-associated molecular patterns of microbes. Activation of TLRs by pathogen-associated molecular patterns leads to the induction of an inflammatory cascade and activation of both innate and adaptive arms of the immune response. TLRs have been implicated in the pathogenesis of various inflammatory diseases, including uveitis. This review provides an update on recent progress in TLR research and uveitis, specifically summarizing new evidence for the role of TLRs in anterior uveitis. There have been important observations from studies involving human ocular tissue, clinical uveitis and from experimental animal models of uveitis, such as endotoxin-induced uveitis. The 'Toll rush' has certainly gained momentum, and future advances in this field have the potential for selectively targeting the TLR pathway and ultimately translating into better therapies for patients with sight-threatening uveitis.
Lower Bounds on Data Collection Time in Sensory Networks (2004)

Data collection, i.e., the aggregation at the user location of information gathered by sensor nodes, is a fundamental function of sensory networks. Indeed, most sensor network applications rely on data collection capabilities, and consequently, an inefficient data collection process may adversely affect the performance of the network. In this paper, we study via simple discrete mathematical models, the time performance of the data collection and data distribution tasks in sensory networks. Specifically, we derive the minimum delay in collecting sensor data for networks of various topologies such as line, multiline, and tree and give corresponding optimal scheduling strategies. Furthermore, we bound the data collection time on general graph networks. Our analyses apply to networks equipped with directional or omnidirectional antennas and simple comparative results of the two systems are presented.
ChemInform Abstract: The First Stereocontrolled Synthesis of Axial‐Equatorial Bislactone Furofuran Lignans Having Two Different Aryl Groups: A Synthesis of Methyl 4,8‐Dioxoxanthoxylol. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interfacial Behavior of Recombinant Forms of Human Pulmonary Surfactant Protein SP-C (2012)

The behavior at air-liquid interfaces of two recombinant versions of human surfactant protein SP-C has been characterized in comparison with that of native palmitoylated SP-C purified from porcine lungs. Both native and recombinant proteins promoted interfacial adsorption of dipalmitoylphosphatidylcholine bilayers to a limited extent, but catalyzed very rapid formation of films from different lipid mixtures containing both zwitterionic and anionic phospholipids. Once at the interface, the recombinant variants exhibited compression-driven structural transitions, consistent with changes in the orientation of the deacylated N-terminal segment, which were not observed in the native protein. Compression isotherms of lipid/protein films suggest that the recombinant SP-C forms promote expulsion at high pressures of a higher number of lipid molecules per mole of protein than does native SP-C. A more dynamic conformation of the N-terminal segment in recombinant SP-C forms is likely also responsible for facilitating compression-driven condensation of domains in anionic phospholipid films as observed by epifluorescence microscopy. Finally, both native palmitoylated SP-C and the phenylalanine-containing recombinant versions facilitate similarly the repetitive compression-expansion dynamics of lipid/protein films, which were able to reach maximal surface pressures with practically no hysteresis along multiple quasi-static or dynamic cycles.
Experimental investigation of the linear and non-linear dynamics of a ducted, laminar premixed flame (2008)

This work investigates experimentally the linear and non-linear dynamics of a ducted, conical, laminar premixed flame under forced acoustic excitation. Upstream travelling acoustic waves hit the flame at varying amplitudes. The flame transfer function is measured. In particular, for velocity disturbance amplitudes close to the mean flow velocity the phase of the transfer function shows significant difference to that at weak excitation. Instantaneous images of the flame under excitation suggest that the non-linearity is associated with the movement of the flame base at high levels
of excitation, which is assumed fixed in the kinematic linear theory. Further work by the group will attempt to explain how non-linearity comes into play at higher forcing amplitudes.