gebhart/patrepeval huggingface dataset:
Structural colocalisation of type VI collagen and fibronectin in agarose cultured chondrocytes and isolated chondrons extracted from adult canine tibial cartilage (1997)

Cell-matrix and matrix-matrix interactions are of critical importance in regulating the development, maintenance and repair of articular cartilage. In this study, we examined the structural colocalisation of type VI collagen and fibronectin in isolated chondrons and long-term agarose cultured chondrocytes extracted from normal adult canine articular cartilage. Using double labelling immunohistochemistry in conjunction with dual channel confocal microscopy and digital image processing we demonstrate that type VI collagen and fibronectin are distributed in a similar staining pattern and are colocalised at the surface of cultured chondrocytes and isolated chondrons. The results suggest that type VI collagen and fibronectin may play a role in both cell-matrix adhesion and matrix-matrix cohesion in the pericellular microenvironment surrounding articular cartilage chondrocytes.
An efficient real-time implementation of the Wigner-Ville distribution (1987)

The Wigner-Ville distribution (WVD) is a valuable tool for time-frequency signal analysis. In order to implement the WVD in real time, an efficient algorithm and architecture have been developed which may be implemented with commercial components. This algorithm successively computes the analytic signal corresponding to the input signal, forms a weighted kernel function, and analyzes the kernel via a discrete Fourier transform (DFT). To evaluate the analytic signal required by the algorithm, it is shown that the time domain definition implemented as a finite impulse response (FIR) filter is practical and more efficient than the frequency domain definition of the analytic signal. The windowed resolution of the WVD in the frequency domain is shown to be similar to the resolution of a windowed Fourier transform. A real-time signal processor has been designed for evalution of the WVD analysis system. The system is easily paralleled and can be configured to meet a variety of frequency and time resolutions. The arithmetic unit is based on a pair of high-speed VLSI floating-point multiplier and adder chips.
The purification, characterization, cloning and sequencing of the gene for a halostable and thermostable leucine dehydrogenase from Thermoactinomyces intermedius (1994)

Leucine dehydrogenase has been purified to homogeneity from a moderate thermophilic actinomycete, Thermoactinomyces intermedius IFO 14230. The enzyme can be stored without loss of its activity at a low temperature (e.g., 4 degrees C) for over two years. The enzyme was more thermostable at higher concentrations of salts such as NaCl and KCl. It retained about 90% of activity on incubation at 70 degrees C for at least 40 min in the presence of 3 M NaCl. The Michaelis constants for NAD, L-leucine, NADH, 2-oxoisocaproate and ammonia were determined to be 0.36, 2.0, 0.042, 0.63 and 118 mM, respectively, from initial-velocity analyses. The enzyme showed pro-S stereospecificity for hydrogen transfer of NADH in the reductive amination. The enzyme gene was cloned into Escherichia coli and its complete DNA sequence was determined. The leucine dehydrogenase gene (leudh) consists of a 1098-bp open reading frame and encodes 366 amino acid residues corresponding to a subunit (M(r) 40586) of the octameric enzyme. The amino acid sequence of the enzyme showed 80.7% similarity with that of the Bacillus stearothermophilus enzyme. The enzyme was overproduced in E. coli JM 109 having a recombinant plasmid, pULDH2, which was constructed from pUC18 and the leudh gene. The enzyme was purified from the cell extract to homogeneity in one day, with 78% recovery.
Eshu: An Extensible Web Editor for Diagrammatic Languages (2012)

Force-directed algorithms are among the most flexible methods for calculating layouts of simple undirected graphs. Also known as spring embedders, such algorithms calculate the layout of a graph using only information contained within the structure of the graph itself, rather than relying on domain-specific knowledge. Graphs drawn with these algorithms tend to be aesthetically pleasing, exhibit symmetries, and tend to produce crossing-free layouts for planar graphs. In this survey we consider several classical algorithms, starting from Tutte's 1963 barycentric method, and including recent scalable multiscale methods for large and dynamic graphs.
Marine source wavelet and radiation pattern estimation (1990)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1990Marine source wavelet and radiation pattern estimationAuthors: Timothy H. KehoArthur B. WegleinPeter G. RigsbyTimothy H. KehoARCO Oil and Gas Co., Arthur B. WegleinARCO Oil and Gas Co., and Peter G. RigsbyARCO Oil and Gas Co.https://doi.org/10.1190/1.1890087 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1890087FiguresReferencesRelatedDetailsCited byPrediction of the wavefield anywhere above an ordinary towed streamer: Application to source waveform estimation, demultiple, deghosting, data reconstruction and imagingA. B. Weglein, T. H. Tan, S. A. Shaw, K. H. Matson, and D. J. Foster4 January 2005Wavelet spectrum estimationTik Hing Tan7 February 2012 | GEOPHYSICS, Vol. 64, No. 6 SEG Technical Program Expanded Abstracts 1990ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1990 Pages: 1779 publication data© 1990 Copyright © 1990 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Timothy H. Keho, Arthur B. Weglein, and Peter G. Rigsby, (1990), "Marine source wavelet and radiation pattern estimation," SEG Technical Program Expanded Abstracts : 1655-1657. https://doi.org/10.1190/1.1890087 Plain-Language Summary PDF DownloadLoading ...
Deadbeat current control for wind-energy inverter application with LCL filter (2013)

This paper proposes a deadbeat control system for the output LCL filter in a grid-connected inverter with a settling time of three sampling periods. Unlike the conventional analysis, the proposed control algorithm is derived in the descritised time-domain instead of the s-domain. In order to bring the robustness about the grid voltage distortion or the inaccurate inverter with non-linearity between the output voltage and its command, the adaptive predictor which acts as an integral controller is required. Furthermore, a comparison of the measured THD of the grid current is included for two different types of feedback, inverter current feedback and the grid current feedback. From the measured total harmonic distortion (THD) of the grid current, the grid current feedback significantly reduces the THD by 2.0% as compared to the converter current feedback. This is directly due to the detected control variable is precisely controlled in order to follow up its reference current using the adaptive predictor.
Phathalic anhydride as an impurity in industrial atmospheres: assay in air samples by gas chromatography with electron-capture detection (1986)

A gas-chromatographic method utilising a 63Ni electron-capture detector was developed for the measurement of phthalic anhydride in air samples. The limit of detection for the anhydride in solution was 5 pg µl–1 and in air samples 0.0004 mg m–3(0.00007 p.p.m.) with a sample volume of 12 l. This indicates a superior sensitivity in comparison with former techniques.Industrial phthalic anhydride processes take place at elevated temperatures. The anhydride vaporises (sublimes) and appears in the air as vapour, fume and dust. These impurities of factory air were collected both on membrane filters and in Tenax porous polymer tubes equipped with pre-filters. Phthalic anhydride was found partly to penetrate the membrane filters, which are also used in older methods. For Tenax tubes, a breakthrough of 6% was noted at an anhydride concentration of 2.5 mg per tube, when the sample volume was 12 l. Large particles were apparently retained by the filter whereas vapour and condensed fume were found partly in the adsorbent tube.Atmospheric phthalic anhydride concentrations measured during industrial processes did not exceed the current Western reference values. The present method has particular value for the evaluation of the working conditions of workers with suspected sensitisation.
A 32nm logic technology featuring 2<sup>nd</sup>-generation high-k + metal-gate transistors, enhanced channel strain and 0.171&#x03BC;m<sup>2</sup> SRAM cell size in a 291Mb array (2008)

A 32 nm generation logic technology is described incorporating 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> -generation high-k + metal-gate technology, 193 nm immersion lithography for critical patterning layers, and enhanced channel strain techniques. The transistors feature 9 Aring EOT high-k gate dielectric, dual band-edge workfunction metal gates, and 4 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> -generation strained silicon, resulting in the highest drive currents yet reported for NMOS and PMOS. Process yield, performance and reliability are demonstrated on a 291 Mbit SRAM test vehicle, with 0.171 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> cell size, containing >1.9 billion transistors.
Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings (2016)

In this study, renal sympathetic denervation showed safety using five types of catheters when applying RF-energy less than 10 W, within main stems of arteries larger than 3.0 mm diameter and a distance between lesions of at least 1 time catheter tip length.
Frequency of isolation of environmental mastitis-causing pathogens and incidence of new intramammary infection during the nonlactating period (1988)

Quarter samples (n = 6,328) of mammary secretions were collected from 160 cows during physiologic transitions of the udder to determine the frequency of isolation of mastitis-causing pathogens and the incidence of new intramammary infections (IMI) during the nonlactating period. None of the cows in the herd was infected with Streptococcus agalactiae, and the prevalence of Staphylococcus aureus was low. Cows were not treated with antibiotics at cessation of milking. A threefold increase in the percentage of quarters infected with major mastitis-causing pathogens developed from late lactation to early involution. Coliforms and streptococci other than Str agalactiae accounted for 94% of major pathogen infections. The number of quarters infected with coagulase-negative staphylococci increased slightly from late lactation to early involution, whereas the number of quarters infected with Corynebacterium bovis decreased markedly. Major pathogens caused 101 of 153 IMI at parturition and greater than 90% were caused by streptococci and coliforms. At parturition, 51 of 52 minor pathogen IMI were caused by coagulase-negative staphylococci. During early lactation, there was a marked decrease in quarters infected with major pathogens; however, the number of quarters with major pathogen IMI during early lactation was 2.3 times higher than the number of quarters infected before cessation of milking. The number of quarters with minor pathogen IMI during early lactation was the same as at parturition, but a marked decrease in quarters infected with coagulase-negative staphylococci and a marked increase in C bovis IMI developed from parturition to early lactation.
Supplementary Tables S1-S4 from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival (2023)

Supplementary Tables S1-S4 from Higher Expression of the Androgen-Regulated Gene &lt;i&gt;PSA/HK3&lt;/i&gt; mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival
A New Procedure for the Enantioselective Vinylogous Aldol Reaction of Chan′s Diene. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chapter 14. Translational Approach to Treating Diabetes Using Acupuncture or Electroacupuncture (2013)

Diabetes mellitus is an increasingly prevalent disease that can damage many structures in the body. It was estimated that more than 285 million people in the world had diabetes in 2009; this has risen to 347 million in 2011 and is expected to increase to 438 million by 2030.1 A global health problem...
El taller de educación infantil de la Universidad de Cádiz (2014)

Desde la implementacion de los nuevos Grados de Magisterio nuestros alumnos no realizan su periodo de practicas hasta el sexto semestre de la carrera (segundo semestre de tercer curso). Para acudir a sus practicas con acercamientos a la realidad del aula, se ha creado en la Facultad de CC de la Educacion El Taller de Educacion Infantil. Al taller hemos querido vincular las asignaturas de primero y segundo del Grado de Educacion Infantil (en adelante E.I.) poniendo en relacion los contenidos y competencias que se estan trabajando desde las asignaturas de Psicologia y de Didactica. Los contenidos relacionados con la Psicologia del desarrollo y de la Educacion nos sirven de base para desarrollar metodologias que, en la practica, en la asignatura El Docente en E.I. ayudan a adquirir competencias relacionadas con su desempeno profesional. Por otro lado realizamos practicas de role-play, en el taller de dramatizacion, con actores que interpretan los distintos estilos parentales para nuestro alumnado, teniendo estos que abordar una tutoria inesperada, desarrollando asi las competencias recogidas en la asignatura Tutoria y familia en E.I. Asi mismo, se imparten cursos de manejo de la pizarra digital Promethean (instalada en todos los centros publicos de la comunidad Andaluza). Finalmente, concertamos visitas del alumnado de Segundo Ciclo de E.I. procedentes de distintos centros educativos de la provincia de Cadiz para que nuestro alumnado ponga en practica las competencias adquiridas.
Development of a State-of-the-Art Transient Test Facility for Powertrain R&D (2009)

&lt;div class="htmlview paragraph"&gt;To serve the increasing demand of the automotive industry for transient systems evaluation, the Powertrain Control Research Laboratory (PCRL) has developed a transient test facility which uses high-bandwidth hydraulic dynamometers for hardware-in-the-loop powertrain simulation and testing. Following building renovation in 2006, the research team assumed the task of reconfiguring the dynamometer laboratory into a state-of-the-art testing facility. This includes the relocation and design of support facilities for both single- and multi-cylinder engine transient test systems.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper introduces the applications of transient testing facilities and describes the unique challenges faced by the research team to achieve a versatile powertrain research environment with emphasis on accessibility and optimal space utilization, maintainability, and comprehensive documentation to aid future research endeavors. The conclusions reached serve as evaluations of the success of each implementation chosen, and also provide a comparative and informative reference for those involved in transient test facility development.&lt;/div&gt;
Therapists' perspectives on a new portable hand telerehabilitation platform for home-based personalized treatment of stroke patients. (2021)

In sum, the results encourage and support fine-tuning of the PHTP, commercializing it, and conducting prospective clinical studies.
Correction factors for estimating potassium concentrations in samples with in vitro hemolysis: a detriment to patient safety. (2009)

Use of correction factors for estimating the true potassium concentration in samples with evidence of in vitro hemolysis is not recommended. Derivation of correction factors by using samples with nonsimulated in vitro hemolysis suggests that the actual increase in potassium in hemolyzed samples is much higher than that reported in previous studies that produced hemolysis with artificial means.
Geotechnical Site Assessment by Seismic Piezocone Test in North of Denmark (2013)

These days cone penetration tests (CPT) have gained more popularity as an alternative to the conventional laboratory tests for subsurface investigation and estimation of soil parameters. Due to increasing interest in soil dynamics in the last decades, there is a development of CPT as a seismic piezocone penetration test (SCPTU) which provides shear wave velocity measurements simultaneously with measurements of tip resistance (qc), sleeve friction (fs) and pore pressure (u). The results can be used for determination of deformation parameters of soil. In this regard there have been proposed different empirical correlations between cone data and shear wave velocity measurements to estimate geotechnical parameters but their validity still needs to be verified in a case study and uncertainty remains about the choice of empirical correlations. In this study a site at the East Harbor of Aalborg (sandy site) and another at the Harbor of Frederikshavn (clayey site) in Denmark, where sever al SCPTU tests have been conducted, are considered. The data were used and analyzed based on different correlations presented in the literature. The results are further compared and verified with the measurements of shear wave velocity achieved from SCPTU tests.
Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter (2018)

Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers has been observed to be clinically beneficial. Recent genome-mapping experiments have identified a non-canonical G-quadruplex-forming sequence containing bulges within the PARP1 promoter. Structural features, like bulges, provide opportunities for selective chemical targeting of the non-canonical G-quadruplex structure within the PARP1 promoter, which could serve as an alternative therapeutic approach for the regulation of PARP1 expression. Here we report the G-quadruplex structure formed by a 23-nucleotide G-rich sequence in the PARP1 promoter. Our study revealed a three-layered intramolecular (3+1) hybrid G-quadruplex scaffold, in which three strands are oriented in one direction and the fourth in the opposite direction. This structure exhibits unique structural features such as an adenine bulge and a G·G·T base triple capping structure formed between the central edgewise loop, propeller loop and 5' flanking terminal. Given the highly important role of PARP1 in DNA repair and cancer intervention, this structure presents an attractive opportunity to explore the therapeutic potential of PARP1 inhibition via G-quadruplex DNA targeting.
Controlled multimedia wireless link sharing via enhanced class-based queuing with channel-state-dependent packet scheduling (2002)

A key problem in transporting multimedia traffic across wireless networks is a controlled sharing of the wireless link by different packet streams. So far this problem has been treated as that of providing support for quality of service in time division multiplexing based medium access control protocols (MAC). Adopting a different perspective to the problem, this paper describes an approach based on extending the class-based queueing (CBQ) based controlled hierarchical link sharing model proposed for the Internet. Our scheme enhances CBQ, which works well in wired links such as point-to-point wires of fixed bandwidth, to also work well with wireless links based on radio channels that are (i) inherently shared on-demand among multiple radios, and (ii) are subject to highly dynamic bandwidth variations due to spatially and temporally varying fading with accompanying burst errors. The proposed scheme is based on combining a modified version of CBQ with channel-state dependent packet scheduling.
Impact of Metronomic UFT/Cyclophosphamide Chemotherapy and Antiangiogenic Drug Assessed in a New Preclinical Model of Locally Advanced Orthotopic Hepatocellular Carcinoma (2010)

Hepatocellular carcinoma (HCC) is an intrinsically chemotherapy refractory malignancy. Development of effective therapeutic regimens would be facilitated by improved preclinical HCC models. Currently, most models consist of subcutaneous human tumor transplants in immunodeficient mice; however, these do not reproduce the extensive liver disease associated with HCC or metastasize. To address this deficiency, we developed an orthotopic model. Human HCC cells were transfected with the gene encoding secretable β-subunit human choriogonadotropin (β-hCG), which was used as a surrogate marker of tumor burden. The HCC cells were implanted into the left liver lobe of severe combined immunodeficient (SCID) mice, after which the efficacy of different therapies was evaluated on established, but liver-confined human Hep3B cell line HCC. Treatments included sorafenib or metronomic chemotherapy using cyclophosphamide (CTX), UFT, an oral 5-fluorouracil prodrug, or doxorubicin either alone or in various combinations, with or without an antiangiogenic agent, DC101, an anti-vascular endothelial growth factor receptor-2 antibody. Sorafenib inhibited tumor growth in a dose-dependent manner but caused severe weight loss in SCID mice, thus necessitating use of DC101 in subsequent experiments. Although less toxicity was observed using either single or doublet metronomic chemotherapy without any added antiangiogenic agent, none, provided survival benefit. In contrast, significantly improved overall survival was observed using various combinations of metronomic chemotherapy regimens such as UFT + CTX with DC101. In conclusion, using this model of liver-confined but advanced HCC suggests that the efficacy of a targeted antiangiogenic drug or metronomic chemotherapy can be mutually enhanced by concurrent combination treatment.
Development of the Vibration Isolation System for the Advanced Resistive Exercise Device (2011)

This paper describes the development of the Vibration Isolation System for the Advanced Resistive Exercise Device from conceptual design to lessons learned. Maintaining a micro-g environment on the International Space Station requires that experiment racks and major vibration sources be isolated. The challenge in characterizing exercise loads and testing the system in the presence of gravity led to a decision to qualify the system by analysis. Available data suggests that the system is successful in attenuating loads, yet there has been a major component failure and several procedural issues during its 3 years of operational use.