gebhart/patrepeval huggingface dataset:
W051002 Bioengineering Application of Electro-conjugate Fluid (2015)

Electro-conjugate fluid is a kind of functional fluid, which generates an active flow when subjected to a high DC voltage. Since it only requires a tiny electrode pair in sub-millimeter scale, the electro-conjugate fluid flow can be a possible candidate for fluid power source of micro fluidic systems. On the other hand, micro fluidic systems are gathering attentions in the field of bioengineering, to realize a micro total analysis system or μTAS, which may reduce the volume of samples and regents, analysis time and cost compared with general biochemical analyses. This paper introduces a novel approach for droplets mixing using the electro-conjugate fluid, since mixing droplets are quite often required in the process of biochemical analyses. In the developed droplets mixing device, swirl flow is generated in a chamber by using the electro-conjugate fluid flow generation. Then, droplets whose density is lower than that of electro-conjugate fluid are dripped into the chamber. Due to the density difference, the droplets are subjected to centripetal forces, which make them move to and mix at the center of the chamber. Experimental results confirmed this concept and showed a possibility of the device.
Solidification of colloidal suspensions (2006)

We present a mathematical model of the unidirectional solidification of a suspension of hard-sphere colloids. Similarity solutions are obtained for the volume fraction and temperature profiles ahead of a planar solidification front. The highly nonlinear functional dependence of the diffusion coefficient on the volume fraction gives rise to a range of behaviours. For small particles, Brownian diffusion dominates and the system behaviour is reminiscent of binary-alloy solidification. Constitutional supercooling occurs at the interface under certain conditions, leading potentially to an instability in the shape of the interface. For larger particles, Brownian diffusion is weak and the particles form a porous layer above the interface. In this case constitutional supercooling reaches a maximum near the surface of the layer, and the porous medium itself is potentially unstable. In stable systems there exists the possibility of secondary nucleation of ice.
H5 Influenza Viruses in Egypt (2020)

For almost a decade, Egypt has been endemic for highly pathogenic avian influenza (HPAI) A(H5N1) viruses. In addition to being catastrophic for poultry production, A(H5N1) has also caused 359 human infections in the country (∼40% of global cases), with 120 being fatal. From 2017, A(H5N1) viruses have been gradually replaced by HPAI A(H5N8) viruses seeded from Southeast Asia through Europe; no human cases have been reported since. This lack of human cases is not a consequence of fewer H5 infections in poultry. Despite governmental outbreak control, the number of avian influenza outbreaks has increased since 2006 partially fueled by noncompliance with preventive measures and suboptimal vaccination programs. Adherence to control measures is low because of social norms, especially among women and children-the main caretakers of household flocks in rural areas-and declining public awareness in the community. Egypt has thus become an epicenter for A(H5) virus evolution, with no clear resolution in sight.
Elastic wave thermal fluctuations, ultrasonic waveforms by correlation of thermal phonons (2003)

It is widely recognized that acoustic degrees of freedom coupled to a thermal bath have amplitudes which fluctuate with a mean square proportional to temperature; this is the basis for the Debye theory of the heat capacity of insulating solids. It is shown here that these elastic wave thermal phonons have correlation functions identical to the system's ultrasonic Green's function, and furthermore that thermal noise in ultrasonic detectors should have correlation functions equivalent to conventional waveforms obtained by active transmission and reception. This suggests the possibility of doing ultrasonics without a source. Theory for the identity is presented, and several room temperature laboratory confirmations are conducted in the frequency range 0.1-1.0 MHz. The thermal nature of the origin of these correlations is established by comparing their strength with theoretical expectations. Applications are discussed.
Effects of two-step freezing on the ultra-structural components of murine osteoblast cultures. (2007)

Understanding the ultra-structural response of cells to the cryopreservation process is important for designing cryopreservation strategies for cells and tissues. Cell-cell interaction and cell-scaffold interactions alter cryopreservation response and, in turn, the cellular structures involved in adhesion and intercellular contact are possible targets of cryopreservation-induced damage. Immuno-fluorescence was used to assess the status of the actin filaments (F-actin), focal adhesions (vinculin) and gap junctions (connexin-43) of murine osteoblasts attached to hydroxyapatite (HA) discs and plastic coverslips for a two-step freezing process. The freezing process de-polymerized and distorted the actin filaments of dead cells, while those of live cells experienced little change. Vinculin and connexin-43 structures were rarely seen in dead cells, while a portion of vinculin (8.14+/-2.27 percent) and connexin-43 (21.7+/-4.7 percent) structures remained in live cells. These results suggest that focal adhesions and gap junctions may support cell robustness during cryopreservation. The present study contributes to our knowledge of the damage mechanisms associated with attached cells during a freezing process.
Roles of p-ERM and Rho–ROCK signaling in lymphocyte polarity and uropod formation (2004)

Front-rear asymmetry in motile cells is crucial for efficient directional movement. The uropod in migrating lymphocytes is a posterior protrusion in which several proteins, including CD44 and ezrin/radixin/moesin (ERM), are concentrated. In EL4.G8 T-lymphoma cells, Thr567 phosphorylation in the COOH-terminal domain of ezrin regulates the selective localization of ezrin in the uropod. Overexpression of the phosphorylation-mimetic T567D ezrin enhances uropod size and cell migration. T567D ezrin also induces construction of the CD44-associated polar cap, which covers the posterior cytoplasm in staurosporine-treated, uropod-disrupted EL4.G8 cells or in naturally unpolarized X63.653 myeloma cells in an actin cytoskeleton-dependent manner. Rho-associated coiled coil-containing protein kinase (ROCK) inhibitor Y-27632 disrupts the uropod but not the polar cap, indicating that Rho-ROCK signaling is required for posterior protrusion but not for ERM phosphorylation. Phosphorylated ezrin associates with Dbl through its NH2-terminal domain and causes Rho activation. Moreover, constitutively active Q63L RhoA is selectively localized in the rear part of the cells. Thus, phosphorylated ERM has a potential function in establishing plasma membrane "posteriority" in the induction of the uropod in T lymphocytes.
1064: Impact of Pneumoperitoneum on Renal Tissue Oxygenation (2006)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 23, 2006, 9:00 am - 12:00 pm1 Apr 20061064: Impact of Pneumoperitoneum on Renal Tissue Oxygenation Luke M. Fazio, Alexandra E. Perks, BrianD M. Blew, Greg T. Hare, David Mazer, Robert J. Stewart, R. John D’a Honey, and Kenneth T. Pace Luke M. FazioLuke M. Fazio More articles by this author , Alexandra E. PerksAlexandra E. Perks More articles by this author , BrianD M. BlewBrianD M. Blew More articles by this author , Greg T. HareGreg T. Hare More articles by this author , David MazerDavid Mazer More articles by this author , Robert J. StewartRobert J. Stewart More articles by this author , R. John D’a HoneyR. John D’a Honey More articles by this author , and Kenneth T. PaceKenneth T. Pace More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33289-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1064: Impact of Pneumoperitoneum on Renal Tissue Oxygenation." The Journal of Urology, 175(4S), p. 342 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 342 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Luke M. Fazio More articles by this author Alexandra E. Perks More articles by this author BrianD M. Blew More articles by this author Greg T. Hare More articles by this author David Mazer More articles by this author Robert J. Stewart More articles by this author R. John D’a Honey More articles by this author Kenneth T. Pace More articles by this author Expand All Advertisement PDF downloadLoading ...
사회․환경변화와 MB정부 직업재활정책의 과제 (2008)

본 연구는 사회․환경 변인에 대한 분석을 토대로 MB정부의 직업재활정책의 목표와 수단, 대상집단에 대한 방향성을 제안하고 직업재활학회와 직업재활학이 추구해야 할 학문적 방향을 구명해보고자 하는 것으로 연구결과를 통해 나타난 결론과 정책적 방안을 요약하면 다음과 같다. MB정부는 지난 문민정부, 국민의 정부, 참여정부로의 정치체제가 이관되는...
VLTI pupil transfer: variable curvature mirrors: II. Plasticity, hysteresis, and curvature control (2000)

Progress in Active Optics Methods have led to the invention of Variable Curvature Mirrors. VCMs are useful to provide optical path compensations of the imaged field of view. Preliminarily developed for Fourier transform IR spectrometers, they are now used for the coherent beam recombination of the VLT array. With the VLT Interferometer, a highly flexible VCM will be installed at the focal surface of each cat's eye delay lines. The VCM developments led to the design choice of metal substrates in a quenched state which are at least 15 times more flexible--to external loading--than gloss or vitroceram substrates and thus, have provided accurately the large zoom-range from f/(infinity) to f/2.6. Due to the very large zoom range provided by such active mirrors, it has been found necessary to take under consideration the small plastical deformation as well as the small hysterese loop deformation of the metal substrate. With the four VCMs such as now built for the 8 m telescopes, a plastical deformation model and a hysterese loop model have been determined and are presently described. Including these compensations, the VCM optical figures have been improved and the control software now performs a curvature resolution in between 10<SUP>-3</SUP> and 5 10<SUP>-4</SUP>.
Deep Reinforcement Learning amidst Lifelong Non-Stationarity (2020)

As humans, our goals and our environment are persistently changing throughout our lifetime based on our experiences, actions, and internal and external drives. In contrast, typical reinforcement learning problem set-ups consider decision processes that are stationary across episodes. Can we develop reinforcement learning algorithms that can cope with the persistent change in the former, more realistic problem settings? While on-policy algorithms such as policy gradients in principle can be extended to non-stationary settings, the same cannot be said for more efficient off-policy algorithms that replay past experiences when learning. In this work, we formalize this problem setting, and draw upon ideas from the online learning and probabilistic inference literature to derive an off-policy RL algorithm that can reason about and tackle such lifelong non-stationarity. Our method leverages latent variable models to learn a representation of the environment from current and past experiences, and performs off-policy RL with this representation. We further introduce several simulation environments that exhibit lifelong non-stationarity, and empirically find that our approach substantially outperforms approaches that do not reason about environment shift.
A series of new E. coli–Thermococcus shuttle vectors compatible with previously existing vectors (2018)

Hyperthermophilic microorganisms are an important asset in the toolkits of biotechnologists, biochemists and evolutionary biologists. The anaerobic archaeon, Thermococcus kodakarensis, has become one of the most useful hyperthermophilic model species, not least due to its natural competence and genetic tractability. Despite this, the range of genetic tools available for T. kodakarensis remains limited. Using sequencing and phylogenetic analyses, we determined that the rolling-circle replication origin of the cryptic mini-plasmid pTP2 from T. prieurii is suitable for plasmid replication in T. kodakarensis. Based on this replication origin, we present a novel series of replicative E. coli-T. kodakarensis shuttle vectors. These shuttle vectors have been constructed with three different selectable markers, allowing selection in a range of T. kodakarensis backgrounds. Moreover, these pTP2-derived plasmids are compatible with the single-existing E. coli-T. kodakarensis shuttle vector, pLC70. We show that both pTP2-derived and pLC70-derived plasmids replicate faithfully while cohabitating in T. kodakarensis cells. These plasmids open the door for new areas of research in plasmid segregation, DNA replication and gene expression.
ChemInform Abstract: ASYMMETRIC REACTIONS CATALYZED BY CHIRAL METAL COMPLEXES. VII. CATALYTIC ASYMMETRIC SYNTHESIS OF OPTICALLY ACTIVE β‐AMINO ACIDS (1978)

Abstract Aus den Acetamido‐acrylestern (I) erhält man bei der katalytischen Hydrierung in Gegenwart von optisch aktiven Katalysatoren (II) die Aminosäurederivate (III).
Interconnecting electronic systems (1993)

Interconnecting Electronic Systems presents the fundamental information required for interconnecting audio, video, data, and radio frequency systems. This useful handbook examines the tasks and functions for which system engineers generally find themselves responsible, and it discusses the steps required to complete complex projects. Project organization and management, the requirements of technical documentation, details on equipment rack enclosures, guidelines to follow on wiring practices, and proper procedures for grounding electronic equipment are among the topics covered. This book takes a unified approach in examining all elements involved in interconnecting electronic systems. As a result, this book is recommended for all electrical engineers and electronics engineers involved with power components, circuits, and systems.
Electrically-latched compliant jumping mechanism based on a dielectric elastomer actuator (2019)

Abstract Jumping mechanisms are useful in robotics for locomotion in unstructured environments, or for self-righting abilities. However, most rigid robots rely on impact with the ground to jump, thereby requiring a relatively rigid, and flat environment. Moreover, they need to be able to absorb high impact forces during landing in order to maintain structural integrity. In this paper we investigate soft systems, capable of jumping repeatedly in unstructured environments with no need for precise landings. Our impulsive approach is based on a soft electro-mechanical transducer, a dielectric elastomer actuator (DEA). The design is inspired by click-beetles and simple bio-mechanical models, which convert the flexing around a hinge into jumping. Our actuator is power amplified by the addition of a stiffer strip, allowing for rapid shape transitions (22 ms) between flat and curved states. The transition is controlled by an electric latch: the DEA is discharged faster than the actuator can deform. The mechanical energy stored in the composite beam is released rapidly, leading to impulsive motions (jumps of a full body length: i.e. 5 cm). This demonstration of an electrically-latched power amplification mechanism shows that relatively simple electro-mechanical systems can exhibit impulsive behavior which may enable new types of locomotion in compliant machines.
Improved patient outcome with smoking cessation: when is it too late? (2011)

Smoking is the leading modifiable risk factor for chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), and lung cancer. Smoking cessation is the only proven way of modifying the natural course of COPD. It is also the most effective way of reducing the risk for myocardial infarction and lung cancer. However, the full benefits of tobacco treatment may not be realized until many years of abstinence. All patients with COPD, regardless of severity, appear to benefit from tobacco treatment. Similarly, patients with recent CVD events also benefit from tobacco treatment. The risk of total mortality and rate of recurrence of lung cancer is substantially lower in smokers who manage to quit smoking following the diagnosis of early stage lung cancer or small cell lung cancer. Together, these data suggest that tobacco treatment is effective both as a primary and a secondary intervention in reducing total morbidity and mortality related to COPD, CVD, and lung cancer. In this paper, we summarize the evidence for tobacco treatment and the methods by which smoking cessation can be promoted in smokers with lung disease.
ZigBee and Bluetooth Network based Sensory Data Acquisition System (2015)

In this era of modernization, lots of systems have been introduced by which the human effort has been limited to a certain level. In this Paper a data acquisition system has been proposed for factories and industries or environment monitoring, which will measure the certain parameters like temperature, humidity, the level of gases present in atmosphere, motion of any person near the restricted areas at a time and transmit these parameters to the control room wirelessly as well as to the concerned person of the area by the latest smartphone/tablets. Through the smartphone, the person can give command to the control room in case of any parameter crosses a certain level. The data is collected from sensor nodes to the control room node using ZigBee network and then retransmit the desired data to smart phones, tabs and PCs using Bluetooth network. Sensor node contains analog output sensors like temperature, gas and Digital output sensors like sound and metal. The LCD is used to display the sensor parameters. The RF modem is used to transmit the values to the control room node using star and mesh network topologies. The control room node contains ZigBee transceiver module to receive the information and Bluetooth modem to make available the desired data to the smart phones, tabs and PCs. The ZigBee and Bluetooth network are working at 9600 baud rate and 2.4 GHz frequency in ISM band. The ZigBee nodes are capable to transmit the information upto 100meteres and for long distance communication, multi-hopping is used. Bluetooth modem is capable to transmit the information upto 30 feet distance.
Effects of Maternal HIV Infection on Early Kaposi Sarcoma-Associated Herpesvirus Seroconversion in a Kenyan Mother-Infant Cohort (2023)

Maternal HIV infection reduced a child's initial KSHV antibody levels but did not affect age of infection. Regardless of HIV exposure in utero, KSHV seroconversion in Kenyan children occurred early; associated factors must be identified.
Agave and sisal fibre-reinforced polyfurfuryl alcohol composites (2016)

Agave Americana (agave) and Agave sisalana (sisal) fibres belong to the same family of natural fibres. Both the fibres were treated with alkali. Interestingly, alkali-treated agave fibres displayed a clean and smooth surface, whereas alkali-treated sisal fibres showed a rough surface due to the rupture of alkali-sensitive bonds. This indicated that the sisal fibres are more susceptible to alkali treatment as compared to agave fibres. The experimental studies of chemical composition, Fourier transform infrared spectroscopy and X-ray diffraction were also carried out. Both alkali-treated agave and sisal fibres were used to reinforce polyfurfuryl alcohol (PFA) matrix. The effect of these fibres on the mechanical and thermo-mechanical properties of PFA composites was examined. Mechanical, thermal and thermo-mechanical properties of the composites were studied. The results indicated the improvement in mechanical and thermal properties of the reinforced PFA.
Novel Stable Compounds in the C-H-O Ternary System at High Pressure (2016)

The chemistry of the elements is heavily altered by high pressure, with stabilization of many new and often unexpected compounds, the emergence of which can profoundly change models of planetary interiors, where high pressure reigns. The C-H-O system is one of the most important planet-forming systems, but its high-pressure chemistry is not well known. Here, using state-of-the-art variable-composition evolutionary searches combined with quantum-mechanical calculations, we explore the C-H-O system at pressures up to 400 GPa. Besides uncovering new stable polymorphs of high-pressure elements and known molecules, we predicted the formation of new compounds. A 2CH4:3H2 inclusion compound forms at low pressure and remains stable up to 215 GPa. Carbonic acid (H2CO3), highly unstable at ambient conditions, was predicted to form exothermically at mild pressure (about 1 GPa). As pressure rises, it polymerizes and, above 314 GPa, reacts with water to form orthocarbonic acid (H4CO4). This unexpected high-pressure chemistry is rationalized by analyzing charge density and electron localization function distributions, and implications for general chemistry and planetary science are also discussed.
Tree Skeleton Extraction From Laser Scanned Points (2019)

The tree skeleton is one of the important parameters for building 3D model of the tree. The accurate extraction of tree skeleton is of great significance for tree visualization. This paper proposed an effective method for extracting tree skeleton of individual trees. The complexity of canopy structure was reduced by slicing. The leaf and wood components were separated by combining classification and segmentation methods. L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -median algorithm was used to extract the tree skeleton points accurately. The results show that the method can accurately extract the tree skeleton from terrestrial LiDAR data. The extracted skeleton had a good conformance with the point cloud of the tree in morphology.
Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development (2011)

Cancer cells have developed numerous ways to escape immune surveillance and gain unlimited proliferative capacity. Currently, several chemotherapeutic agents and radiotherapy, either alone or in combination, are being used to treat malignancies. However, both of these therapies are associated with several limitations and detrimental side effects. Therefore, recent scientific investigations suggest that immunotherapy is among the most promising new approaches in modern cancer therapy. The focus of cancer immunotherapy is to boost both acquired and innate immunity against malignancies by specifically targeting tumor cells, and leaving healthy cells and tissues unharmed. Cellular, cytokine, gene, and monoclonal antibody therapies have progressively become promising immunotherapeutic approaches that are being tested for several cancers in preclinical models as well as in the clinic. In this review, we discuss recent advances in these immunotherapeutic approaches, focusing on new strategies that allow the expression of specific immunostimulatory molecules on the surface of tumor cells to induce robust antitumor immunity.
Epithelial-mesenchymal transition phenotypes of circulating tumor cells correlate with the clinical stages and cancer metastasis in hepatocellular carcinoma patients (2017)

CTCs count and EMT classification are correlated with clinical stages and metastasis of HCC, suggesting that they may be potential markers for the early diagnosis of HCC metastasis and progression.
Corrigendum: Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies (2023)

[This corrects the article DOI: 10.3389/fimmu.2023.1067352.].