gebhart/patrepeval huggingface dataset:
Glycovariant CD37 Small Modular Immuno-Pharmaceutical (TruADhanCe™ SMIP) Promotes Enhanced Natural Killer Cell Mediated Cytotoxicity against Primary Chronic Lymphocytic Leukemia Cells. (2009)

Abstract Abstract 1744 Poster Board I-770 CD37 is a tetraspanin transmembrane family protein that is strongly expressed on the surface of mature human B-cells and transformed mature B-cell lymphoma and leukemia cells, including CLL cells. It is expressed minimally or is absent on normal T-cells, natural killer cells, monocytes, and granulocytes. Predominant expression of CD37 on CLL cells makes it an ideal candidate to target with potential agents for treatment of CLL. TRU-016, a Small Modular ImmunoPharmaceutical protein (SMIP) targeted towards the extracellular region of CD37, is presently in clinical trials in CLL patients. TRU-016 consists of variable regions (scFv) and engineered constant regions encoding the human IgG1 domains. We have previously reported that SMIP-016, the chimeric precursor of the fully humanized TRU-016, induced apoptosis in CLL B cells in the presence of goat anti-human Fc ab cross-linker through a novel, caspase-independent pathway. Furthermore, SMIP-016 showed potent in-vivo activity in a SCID xenograft mouse model. Aside from direct cytotoxicity, SMIP-016 mediates antibody-dependent cellular cytotoxicity (ADCC) by NK cells both in vitro and in vivo. Recently, in an attempt to enhance the ADCC function, a new variant of SMIP-016, Tru-ADhanCe SMIP-016, has been created with a modification of the glycosylation of the Fc portion of the molecule. TRU-ADhanCe SMIP-016 has been shown to exhibit enhanced binding to both low- and high-affinity molecular variants of human CD16 (FcRIII) and augmented ADCC potency when compared to SMIP-016. In this study, we compared TruADhanCe SMIP-016 and SMIP-016 in direct cytotoxicity and ADCC experiments using CLL B-cells. While SMIP-016, and TruADhanCe SMIP-016 mediated comparable direct cytotoxicity at 24, 48 and 72 hrs in the presence of anti-human Fc crosslinker, the TruADhanCe SMIP-016 resulted in 2 to 4 fold increased NK cell mediated ADCC function. Consistent with the comparable direct cytotoxic effects, the early phosphorylation patterns were similar in cells treated with TruADhanCe SMIP-016 or SMIP-016 in the presence of anti-human Fc cross linker. Ongoing studies are aimed to define the mechanistic basis of the enhanced ADCC function by TruADhanCe SMIP-016 and to determine if use of soluble CD16.Fc as a cross-linker, an in vitro model of in vivo Fc receptor binding, may reveal enhanced apoptotic-signaling of TruADhanCe SMIP-016. These results suggest potential use of TruADhanCe versions of TRU-016 with enhanced ADCC function as an alternate for TRU-016 in B cell malignancies including CLL therapy. [This work was supported by D. Warren Brown Foundation, Leukemia and Lymphoma Society and National Cancer Institute.] Disclosures Thompson: Trubion Pharmaceuticals: Employment. Siadak:Trubion Pharmaceuticals: Employment. Algate:Trubion Pharmaceuticals: Employment. Cerveny:Trubion Pharmaceuticals: Employment.
Kolmogorov-Smirnov Test-Based Actively-Adaptive Thompson Sampling for\n Non-Stationary Bandits (2021)

We consider the non-stationary multi-armed bandit (MAB) framework and propose\na Kolmogorov-Smirnov (KS) test based Thompson Sampling (TS) algorithm named\nTS-KS, that actively detects change points and resets the TS parameters once a\nchange is detected. In particular, for the two-armed bandit case, we derive\nbounds on the number of samples of the reward distribution to detect the change\nonce it occurs. Consequently, we show that the proposed algorithm has\nsub-linear regret. Contrary to existing works, our algorithm is able to detect\na change when the underlying reward distribution changes even though the mean\nreward remains the same. Finally, to test the efficacy of the proposed\nalgorithm, we employ it in two case-studies: i) task-offloading scenario in\nwireless edge-computing, and ii) portfolio optimization. Our results show that\nthe proposed TS-KS algorithm outperforms not only the static TS algorithm but\nalso it performs better than other bandit algorithms designed for\nnon-stationary environments. Moreover, the performance of TS-KS is at par with\nthe state-of-the-art forecasting algorithms such as Facebook-PROPHET and ARIMA.\n
METHOD OF PREDICTING URINARY VOLUME BY UTILIZING THE ABSORPTION SPECTRUM OF URINE (2019)

Urinary incontinence is one of the serious problems encountered while providing nursing care to older patients. In clinical situations, caregivers use ultrasonic sensors for monitoring accumulated urinary volume in the bladder so that they can take older patients to the toilet before urinary incontinence. However, if the caregiver is delayed in checking the accumulated urinary volume, the patient may experience urinary incontinence. While making nursing schedules for excretion management, caregivers may find it useful if they could predict the accumulated urinary volume in the bladder immediately after urination. Hence, in this study, we propose a prediction method based on the urinary accumulation model and absorption spectrum of urine. The urinary accumulation model contains three parameters: the time when urine starts to accumulate after urination; the amount of urine that can be accumulated in the bladder; and the time constant of urine accumulation. Thus, if these parameters can be determined immediately after urination, the accumulated urinary volume can be predicted using this model. To determine the values of these three parameters, we used the absorption spectrum of urine, as an explanatory variable, in the ridge regression technique. The values of the three parameters (as objective variables in the ridge regression) were obtained from output signals of the ultrasonic sensor using the internal point method. To evaluate the proposed method, we performed a validity experiment with a male subject in his 20s. The ultrasonic sensor was attached to subjects to measure accumulated urinary volume in the bladder. The subject was asked to rest during measurement. Urine samples were collected at arbitrary intervals. Absorption spectrum analysis was performed with the urine samples. The volume of the sampled urine was measured using the measuring cup. After urination, the subject was asked to drink 300 ml of water and rest again. The above procedure was repeated. In this experiment, we obtain 42 datasets in total from the subject. We calculated the rate of error between volume of the collected urine and the urinary volume predicted by the proposed model at the time of urination. Our results showed that the average error rate for the proposed method was 22.22% and for the ultrasonic sensor was 24.14%. This result indicates that the proposed method may be useful for predicting the accumulated urinary volume in the bladder.
Partial Left Ventriculectomy to Improve Left Ventricular Function in End-Stage Heart Disease (1996)

We present a case of a 34-year-old male with dilated cardiomyopathy in whom we performed a new surgical procedure; i.e., ventricular volume reduction to improve function. This initial human experience was preceded by a series of ten sheep in which we demonstrated that by enlarging the left ventricle (LV), the ejection fraction was reduced, and by restoring normal diameter, the LV function returned to normal.
A 40&#x00B5;W CMOS temperature sensor with an inaccuracy of &#x00B1;0.4&#x00B0;C (3&#x03C3;) from &#x2212;55&#x00B0;C to 200&#x00B0;C (2013)

This paper describes a BJT-based precision CMOS temperature sensor for high temperature (>150°C) applications. By optimizing the bias currents of the sensing BJTs and the design of the readout circuit, the impact of leakage and saturation currents at high temperatures is reduced. The sensor was implemented in a 0.16-μm CMOS SOI process and operates from -55°C to 200°C, achieving an inaccuracy of ±0.4°C (3σ) after a trim at 30°C. In a conversion time of 5.3msec, it achieves a resolution of 20mK, while drawing 22μA from a 1.8V supply.
The Development of Dominance Stripes and Orientation Maps in a Self-Organising Visual Cortex Network (VICON) (2010)

A self-organising neural network is presented that is based on a rigorous Bayesian analysis of the information contained in individual neural firing events. This leads to a visual cortex network (VICON) that has many of the properties emerge when a mammalian visual cortex is exposed to data arriving from two imaging sensors (i.e. the two retinae), such as dominance stripes and orientation maps.
Reg3β from cardiomyocytes regulated macrophage migration, proliferation and functional skewing in experimental autoimmune myocarditis. (2018)

Macrophages play critical roles in inflammatory initiation, development, resolution and cardiac regeneration of myocarditis. However, Reg3β, as a member of regenerating family of proteins, contributes to dedifferentiation of injury cardiomyocytes as well as cardiac function remodeling. It remains unclear whether Reg3β was associated with macrophages reprogramming during autoimmune myocarditis. Our results showed that Reg3β could effectively recruit macrophages, promoted their proliferation and phagocytosis, and facilitated their polarized into M2 macrophages. Macrophage, especially M1 phenotype contributed to Reg3β production by cardiomyocytes. Our data also indicated that Reg3β was involved in self-protection mechanism following cardiac injury or stress. This suggests that Reg3β might be a critically protective factor of myocardium.
Switching to Iloperidone (2014)

Switching to iloperidone can be accomplished either with a gradual crossover or immediate discontinuation of the prior antipsychotic; however, the immediate-switch method is associated with greater proportion of initial dizziness. The observed outcomes are consistent with what has been previously reported regarding iloperidone's favorable akathisia/EPS profile and modest impact on somnolence/sedation, body weight, and metabolic variables.
Human pregnancy levels of estrogen and progesterone contribute to humoral immunity by activating T FH /B cell axis (2020)

Circulating T<sub>FH</sub> (cT<sub>FH</sub> ) cells express CXCR5, PD-1, and, when activated, ICOS, and release IL-21. According to the production of IFN-γ, IL-4, and IL-17 and expression of FoxP3, these cells are also classified as cT<sub>FH</sub> 1, cT<sub>FH</sub> 2, cT<sub>FH</sub> 17, and cT<sub>FR</sub> cells, respectively. This CD4<sup>+</sup> T-cell subset is pivotal to efficient humoral immunity, and pregnancy appears to favor IgG production. Here, not only pregnancy amplified the in vivo production of anti-HBsAg IgG in HBV immunized women, but the frequency of cT<sub>FH</sub> cells was directly correlated with estradiol levels. In vitro, pregnancy-related dose of 17-β-estradiol (E2) directly increased the percentage of different cT<sub>FH</sub> subsets. While E2 and progesterone (P4) increased the proportion of differentiated T<sub>FH</sub> cells derived from naïve CD4<sup>+</sup> T-cells, only E2 amplified the release of IL-21 in those cell cultures. In addition, E2 and P4 increased the proportion of memory B cells and plasma cells, respectively. In SEB-activated B/T<sub>FH</sub> cell co-cultures, E2, in the presence of P4, increased the production of total IgG. Finally, among the hormones, P4 was stronger in upregulating the percentage of IL-10<sup>+</sup> T<sub>FR</sub> cells. Collectively, our findings suggested that E2 and P4 cooperate in the humoral immune response by favoring the expansion of different cT<sub>FH</sub> and B cell subsets.
Electrically tunable and switchable film bulk acousitc resonator (2005)

The paper describes an electrically tunable and switchable film bulk acoustic resonator (FBAR) that is formed by integrating an FBAR with an electrostatic MEMS actuator. Around /spl sim/0.8% tuning of the series resonant frequency (/spl Delta/f/spl cong/18 MHz) at 2.3 GHz is experimentally obtained with an electrostatic actuation voltage varying between 12.2 and 27.5 V. Also, a switchable resonator with Q (quality) factor of greater than 100 at 2.2 and 4.0 GHz is experimentally demonstrated in a compact device area.
Recombinant Activated Coagulation Factor VII and Prothrombin Complex Concentrates Are Equally Effective in Reducing Hematoma Volume in Experimental Warfarin-Associated Intracerebral Hemorrhage (2011)

Our results suggest that PCC and rFVIIa are equally effective in restoring coagulation and preventing excessive hematoma growth in acute warfarin-associated intracerebral hemorrhage.
Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue (2011)

We propose an analog-digital hybrid circuit model of one-dimensional cardiac tissue with hardware implementation that allows us to perform real-time simulations of spatially conducting cardiac action potentials. Each active nodal compartment of the tissue model is designed using analog circuits and a dsPIC microcontroller, by which the time-dependent and time-independent nonlinear current-voltage relationships of six types of ion channel currents employed in the Luo-Rudy phase I (LR-I) model for a single mammalian cardiac ventricular cell can be reproduced quantitatively. Here, we perform real-time simulations of reentrant excitation conduction in a ring-shaped tissue model that includes eighty nodal compartments. In particular, we show that the hybrid tissue model can exhibit real-time dynamics for initiation of reentries induced by uni-directional block, as well as those for phase resetting that leads to annihilation of the reentry in response to impulsive current stimulations at appropriate nodes and timings. The dynamics of the hybrid model are comparable to those of a spatially distributed tissue model with LR-I compartments. Thus, it is conceivable that the hybrid model might be a useful tool for large scale simulations of cardiac tissue dynamics, as an alternative to numerical simulations, leading toward further understanding of the reentrant mechanisms.
Comparative anatomy on structure and distribution of secretory canals in different organs of Cryptotaenia japonica Hassk. (Apiaceae) (2009)

The structure and distribution characters of secretory canals in different organs of Cryptotaenia japonica Hassk.(Apiaceae) were comparatively observed by the paraffin section method.The observation results show that there are secretory canals in root,stem,leaf and mericarp of C.japonica,and the secretory canals specialize to vittaes in mericarp.The secretory canals consist mostly of a layer of secretory cells smaller than the parenchyma cells around them.The lumina and secretory cells of secretory canals in different organs are variant in sizeand shape.The number of secretorycells in root is mainly 4-5,less than that in stem,which is 6-9(sometimes 12-14).The number of secretory cells is not the same in different parts of leaf,there are 22 secretory cells in vein but only 3 in mesophyll.The secretory canals in root only distribute in pericycle near the periderm of main root and the first lateral root,as well as in outside the phloem and in pith of main root.In stem,the secretory canals distribute in cortex near the epidermis and regions between the big collenchyma and the phloem,as well as in pith approaching the xylem.The secretory canals in leaf sheath and petiole locate at top of small collenchyma,regions between the collenchyma and the phloem and periphery of the xylem,while there are a few secretory canals between two collenchymas in leaf sheath.The secretory canals of the primary vein and main lateral vein in blade situated in space between collenchyma and vascular bundle,and in the palisade parenchyma of mesophyll.The vittaes distribute between endocarp and mesocarp,mostly in the rib vallecula and on the commissure.In addition,the distribution pattern of secretory canals is obviously different in root and stem.The distribution pattern of secretory canals at the abaxial and adaxial surfaces of leaf sheath combines the characteristics of secretory canals in cortex of stem and in xylem of petiole,respectively,showing the transition from stem to petiole.There are two layers of oil cells under the vascular of mericarp rib and between vittaes,which almost distribute around the mericarp,this structure feature is rare in Apiaceae species and worth further studying.
Optical simulation of top-emitting organic light emitting diodes (2004)

An optical model based on classical electrodyanmics has beeb exploited to simulate the optical effects for the top-emitting organic light emitting diodes. The optical performance of the devices can be obtained through calculation of the power density in each planar thin film. The far field emission profile and spectrum are derived base on this model. Predicated optical performance is compared with experiments Keywords: Top-emitting organic light emitting diode, optical modeling, microcavity
SU‐FF‐I‐18: Quantifying the Geometric Accuracy of the On Board Imager Over a One‐Year Period (2006)

Purpose: To quantify the geometric accuracy of the On Board Imager in both the kV radiographic and cone beam imaging modes. Method and Materials: The Winston‐Lutz test was performed to localize a 5mm tungsten sphere placed within +/− 0.25 mm of the radiation isocenter. The sphere was imaged with half fan cone beam scans, and kV radiographs at the 4 principal gantry angles. The displacement of the sphere from the ‘imaging isocenter’ (the actual position of a point object that the imaging system would find to be at isocenter) was determined for each imaging mode. This test has been repeated 18 times over a period of one year. Results: The average displacement of the sphere from the imaging isocenter using a half fan technique was found to be 0.9 mm Right, 0.9 mm Anterior, and 1.1 mm Inferior, assuming a head first supine orientation. These offsets are incorporated in image‐guided patient setup procedures. Small systematic errors as a function of gantry angle were also measured for the radiographs. A point at the radiation isocenter will appear about 1mm higher in a right lateral image than in a left lateral image. A similar left / right discrepancy exits for anterior and posterior images. Conclusion: The systematic geometric errors of the kV imaging equipment and associated techniques need to be measured and incorporated into the procedure of on‐line image‐guided patient treatment. For the On Board Imager, a geometric accuracy of better than 1mm can be achieved.
Intra-cardiac MR imaging & MR-tracking catheter for improved MR-guided EP (2015)

Electrophysiology (EP) studies can diagnose & treat patients with arrhythmia. MR-guided EP is growing, driven by the ability of cardiac MRI to provide high-contrast images. For intra-procedural use, MRI provides images of the acute state of radio-frequency ablation (RFA) lesions, e.g. necrosis, edema and hemorrhage, that potentially reduce recurrences & complications Unfortunately, acquisition of these images using surface MRI coils, considering the high-spatial-resolution (~112mm 3 ) requirements, can be lengthy (scar~10 mins/scan, edema~12 mins/scan) [3], severely increasing the duration of MR-guided procedures. As demonstrated in other body regions, e.g. endorectal MRI, and with other imaging modalities (Intra-Cardiac Echo), intracavitary probes provide increased Signal-to-Noise-Ratio (SNR), due to their proximity to the area of interest. An Intra-cardiac MR imaging (ICMRI) coil may provide substantially higher SNR, but a complete application must also provide accurate heart motion compensation [4], in order to produce non-blurred images. We constructed an ICMRI catheter, with integrated imaging & positional-tracking elements, optimized for (1) cardiovascular introduction as a sheath "riding on" an EP ablation catheter & for (2) close-proximity imaging (~4 cm FOV) during RFA delivery.
Resistance to Phytophthora cinnamomi among seedlings from backcross families of hybrid american chestnut (2012)

American chestnut (Castanea dentata (Marsh.) Borkh.) once was a primary hardwood species in forests of the eastern United States. Sometime during the late 18th century, it is speculated that Phytophthora cinnamomi, which causes Phytophthora root rot (PRR) on many woody plant species, was introduced to the southeast region of the United States, and this pathogen spread as people moved inland from the coast (Zentmyer 1980). In the 1800s, PRR (also known as ink disease) caused extensive mortality to American chestnut trees in the southern portion of its range (Freinkel 2007, Zentmyer 1980). Then, in the early 1900s, chestnut blight, caused by Cryphonectria parasitica, almost eliminated American chestnut trees from eastern forests (Freinkel 2007). Since 1989, The American Chestnut Foundation (TACF) has been producing hybrid chestnut seedlings by crossing Chinese chestnut (C. mollissima), which is resistant to C. parasitica, with American chestnut and then backcrossing progeny to C. dentata to produce resistant American-type chestnut trees. Since 2000, hybrid seedlings planted in some locations in southeastern states have died from PRR before they could be challenged by naturally-occurring populations of C. parasitica. Therefore, we wanted to determine if any of the backcross trees selected for resistance to C. parasitica were resistant to P. cinnamomi as well because Chinese chestnut also is resistant to this pathogen.
Spray cast Al-Si base alloys for stiffness and fatigue strength requirements (1993)

Hypereutectic AlSiFe spray-cast alloys exhibit properties similar to those of metal-matrix composite (MMC's) : high Young's modulus and a low coefficient of thermal expansion. These physical properties can be adjusted by changing the Si content of the alloy. The refinement of the microstructure is produced by formation of a large amount of nuclei in the spray. Consolidation done by extrusion (bars, tubes or profiles) and/or forging leads to high mechanical properties, especially very good dynamic properties. High fatigue properties coupled with high modulus, good high temperature behaviour and low thermal expansion, allow their use for applications in the automotive industry. In opposition to MMC's, these materials present the advantage of easy recycling and easy machinability as it is the case for the conventional AlSi alloys. The low oxygen content allows quality joining with conventional arc welding techniques.
Chemical Vapor Deposition of High‐Quality and Atomically Layered ReS2 (2015)

Recently, anisotropic 2D materials, such as black phosphorus and rhenium disulfides (ReS2 ), have attracted a lot attention because of their unique applications on electronics and optoelectronics. In this work, the direct growth of high-quality ReS2 atomic layers and nanoribbons has been demonstrated by using chemical vapor deposition (CVD) method. A possible growth mechanism is proposed according to the controlled experiments. The CVD ReS2-based filed-effect transistors (FETs) show n-type semiconducting behavior with a current on/off ratio of ≈10(6) and a charge carrier mobility of ≈9.3 cm(2) Vs(-1). These results suggested that the quality of CVD grown ReS2 is comparable to mechanically exfoliated ReS2, which is also further supported by atomic force microscopy imaging, high-resolution transmission electron microscopy imaging and thickness-dependent Raman spectra. The study here indicates that CVD grown ReS2 may pave the way for the large-scale fabrication of ReS2-based high-performance optoelectronic devices, such as anisotropic FETs and polarization detection.