gebhart/patrepeval huggingface dataset:
Some Factors Influencing the Ultraviolet Absorption Spectra of Polynuclear Aromatic Compounds. I. A General Survey1 (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Factors Influencing the Ultraviolet Absorption Spectra of Polynuclear Aromatic Compounds. I. A General Survey1R. Norman JonesCite this: J. Am. Chem. Soc. 1945, 67, 12, 2127–2150Publication Date (Print):December 1, 1945Publication History Published online1 May 2002Published inissue 1 December 1945https://pubs.acs.org/doi/10.1021/ja01228a023https://doi.org/10.1021/ja01228a023research-articleACS PublicationsRequest reuse permissionsArticle Views686Altmetric-Citations164LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The effects of oral liarozole on epidermal proliferation and differentiation in severe plaque psoriasis are comparable with those of acitretin (1998)

The imidazole derivative liarozole is a potent inhibitor of cytochrome P450-dependent 4-hydroxylation of endogenous all-trans retinoic acid, thereby increasing the levels of all-trans retinoic acid in both plasma and skin. As part of a large, double-blind, randomized clinical study, we investigated the cell biological alterations in uninvolved and lesional skin of 20 patients with severe plaque psoriasis, who were treated with either liarozole or acitretin. The extent and severity of the skin lesions, as recorded by the Psoriasis Area and Severity Index score, was significantly reduced (P </=0.05) after 12 weeks of treatment in both the acitretin- and the liarozole-treated group. A significant decrease in the markers for inflammation (neutrophils), epidermal proliferation (Ki-67-positive cells), normal differentiation (transglutaminase) and abnormal differentiation [cytokeratin 16 and skin-derived antileucoproteinase (SKALP), also known as elafin] was seen in both groups. No significant differences were noted in clinical scores or cell biological scores between the liarozole- and acitretin-treated group. None of the markers returned to the levels seen in uninvolved skin or in normal human skin. The expression of epidermal fatty acid binding protein (E-FABP) was only minimally decreased after 12 weeks of treatment, a substantial part of the stratum spinosum remaining positive. SKALP levels in serum fell in both groups with similar kinetics and showed a statistically significant correlation with clinical scores. A remarkable finding in the uninvolved skin of patients treated with liarozole or acitretin was the distinct focal expression of SKALP in the granular layer and the expression of E-FABP in the spinous layers, which is not found in normal human skin. Although the mechanism of action differs fundamentally, liarozole and acitretin show similar effects with respect to clinical effects and cell biological changes in the lesional and non-lesional skin.
Introduction to Reflectarray Antenna (2007)

This chapter contains sections titled: Description of Reflectarray Printed Reflectarray References
New Luminescent Cyclometalated Iridium(III) Diimine Complexes as Biological Labeling Reagents (2003)

We report the synthesis, characterization, and photophysical and electrochemical properties of thirty luminescent cyclometalated iridium(III) diimine complexes [Ir(N-C)(2)(N-N)](PF(6)) (HN-C = 2-phenylpyridine, Hppy; 2-(4-methylphenyl)pyridine, Hmppy; 3-methyl-1-phenylpyrazole, Hmppz; 7,8-benzoquinoline, Hbzq; 2-phenylquinoline, Hpq; N-N = 4-amino-2,2'-bipyridine, bpy-NH(2); 4-isothiocyanato-2,2'-bipyridine, bpy-ITC; 4-iodoacetamido-2,2'-bipyridine, bpy-IAA; 5-amino-1,10-phenanthroline, phen-NH(2); 5-isothiocyanato-1,10-phenanthroline, phen-ITC; 5-iodoacetamido-1,10-phenanthroline, phen-IAA). The X-ray crystal structure of [Ir(mppz)(2)(bpy-NH(2))](PF(6)) has also been investigated. Upon irradiation, all the complexes display intense and long-lived luminescence under ambient conditions and in 77-K glass. On the basis of the photophysical and electrochemical data, the emission of most of these complexes is assigned to an excited state of predominantly triplet metal-to-ligand charge-transfer ((3)MLCT) (dpi(Ir) --> pi(N-N)) character. In some cases, triplet intraligand ((3)IL) (pi --> pi)(N-N or N-C(-)) excited states have also been identified. In view of the specific reactivity of the isothiocyanate and iodoacetamide moieties toward the primary amine and sulfhydryl groups, respectively, we have labeled various biological molecules with a selection of these luminescent iridium(III) complexes. The photophysical properties of the luminescent conjugates have been investigated. In addition, a heterogeneous assay for digoxin has also been designed on the basis of the recognition of biotinylated anti-digoxin by avidin labeled with one of the luminescent iridium(III) complexes.
The detection of e-antigen and e-antibody by the radioimmunoassay (Dainabot Co., Ltd.) was investigated and it was compared with the immunodiffusion (ID) method (1980)

Radioimmunoassay (RIA)によるe抗原・e抗体の検出(Dainabot社製)をHBVキャリアーについて検討するとともに免疫拡散(ID)法との比較検討を行なつた.1) HBVキャリァーはRIA法によると,86%がe抗原,e抗体何れかが陽性と判定され,両者陰性例は5%,判定保留例は9%であった.2) 明らかなe抗原・e抗体共存例は774例中3例にみられたにこ過ぎなかったが,判定保留例のなかには両者共存例と考えられる例が認められた.3) 両者陰性例,判定保留例は無症候性キャリアーに最も少なく,ついで慢性肝炎.肝硬変に多く,肝細胞癌で最も多かった.これは,e抗原価の低い例および両者共存例がこの順に多いためと考えられた.4) ID法の陽性例は1例を除き,RIA法と一致した.また,RIA法によるe抗原陽性例の42%,e抗体陽性例の51%がID法で陰性であった.これはID法に比ベて,RIA法の方が検出感度が高いことを示しているといえる.
Frontside-only processing of 2-D MEMS scanner for miniature dual-axis confocal microendoscopes (2011)

We present a 2-D MEMS scanner for 3.2mm-diameter dual-axis confocal microendoscopes, which is fabricated by only front-side processing. Frontside-only processing greatly simplifies the process and reduces the cost of the fabrication. Furthermore, by removing the conventional backside etch window, the process enables solid, compact, and robust chip designs that significantly eases handling and packaging. To achieve 2-D imaging in dual-axis confocal microscopy, our scanner is gimbaled, but the outer frame of the gimbal is removed in order to minimize the size of the scanner chip. In static operation, the scanner has optical deflection angles of ~±5.5° at 190V and ±3.8° at 100V for the outer and inner axes, respectively. At the torsional resonances, the optical deflection increases to ±11.8° at 1.18kHz for the outer axis and ± 8.8° at 2.76kHz for the inner axis, when the mirror is driven by (62 + 37sinωt)V and (68 + 37sinωt)V, respectively.
Synthesis and Properties of Block Polymers. 5. Phase Seperation Thermodynamics for Star-Branched Systems (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Properties of Block Polymers. 5. Phase Seperation Thermodynamics for Star-Branched SystemsBarry J. Bauer and L. J. FettersCite this: Macromolecules 1980, 13, 5, 1027–1031Publication Date (Print):September 1, 1980Publication History Published online1 May 2002Published inissue 1 September 1980https://pubs.acs.org/doi/10.1021/ma60077a001https://doi.org/10.1021/ma60077a001research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Patient controlled encryption (2009)

We explore the challenge of preserving patients' privacy in electronic health record systems. We argue that security in such systems should be enforced via encryption as well as access control. Furthermore, we argue for approaches that enable patients to generate and store encryption keys, so that the patients' privacy is protected should the host data center be compromised. The standard argument against such an approach is that encryption would interfere with the functionality of the system. However, we show that we can build an efficient system that allows patients both to share partial access rights with others, and to perform searches over their records. We formalize the requirements of a Patient Controlled Encryption scheme, and give several instantiations, based on existing cryptographic primitives and protocols, each achieving a different set of properties.
Role of US and CT in detection of neck metastases of squamous cell carcinomas (2007)

Objective: To optimize the selection of patients eligible for surgical neck treatment optimizing a diagnostic routine to identify neck metastases. Methods: Comparison between sensibility, specificity and diag- nostic accuracy of clinical examination, echography (US), com- puted tomography (CT) in detection of cervical metastases in 53 patients with carcinoma of the upper aerodigestive tract. &#13;\nResults: Clinical examination: sensibility 82.1%, specificity 80%, diagnostic accuracy 81.1%—US with a cut off point for minimal adenopathy diameter of 0.5 cm sensibility 92.8%, specificity 77.3%, diagnostic accuracy 77.3%—US with a cut off point of 1 cm sensibility 82.1%, specificity 80%, diagnostic accuracy 81.1%—US with a cut off point of 1 cm, also considering round shape of multiplicity of the adenopathy: sensibility 82.1%, speci- ficity 80%, diagnostic accuracy 81.1%—CT with cut off point 0.5 cm: sensibility 92.8%, specificity 32%, diagnostic accuracy 64.1%—CT with cut off point 1 cm: sensibility 85.7%, specificity 64%, diagnostic accuracy 75.4%—CT with cut off point 1 cm, also considering central necrosis, extracapsular spread, multi- plicity of adenopathy: sensibility 89.2%, specificity 60%, diag- nostic accuracy 75.5%. &#13;\nConclusions: (a) A neck positive to palpation must be submitted to neck dissection (81.1% possibility of having a metastases); (b) a neck negative to palpation must be further investigated using the US and CT cut off point of 1 cm; (c) the combined use of US and TC does not offer remarkable advantages in detection of metastases.
Potent NK1 Receptor Antagonists: Synthesis and Antagonistic Activity of Various Heterocycles with an N-(3,5-Bis(trifluoromethyl)benzyl)-N-methylcarbamoyl Substituent. (1997)

Various N-[3,5-bis(trifluoromethyl)benzyl]-N-methylcarbamoyl heterocycles (1, 2 and 3) modified at rings A and B in the isoquinolone (1a) and pyrido[3,4-b]pyridine (2a) nuclei were prepared and evaluated for NK1 receptor antagonistic activities. The structure-activity relationship studies on this series, along with conformational analysis, showed that (i) for ring A, 6-membered heterocycles are preferable to 5-membered heterocycles (a ca. 300-fold difference in potency), (ii) the 6-membered ring seems to function as an anchor by fixing the pendant phenyl group in a desirable orientation for receptor binding, and (iii) since compounds with aromatic rings (2) and those with aliphatic rings (3) as ring B both show good potency, this ring does not seem to be essential for receptor recognition. Among the compounds synthesized, the tetrahydropyridine derivatives 3a, 3b and 3f exhibited excellent inhibitory effects both in vitro and in vivo, with potent activity upon oral administration (ED50 = 0.20-0.27 mg/kg) (capsaicin-induced plasma extravasation in guinea pig trachea).
A Learning-Based Context-Aware Quality Test System in B5G-Aided Advanced Manufacturing (2022)

The booming of the industrial Internet of Things (IIoT) brings an exponential increase in industrial devices, calling for more flexible and low-cost communications. The fifth generation and beyond (B5G) communication technologies provide a dedicated solution by supporting two industry-targeted technologies: Massive machine-type communications (mMTC) and ultra reliable low-latency communications (URLLC). In this article, we design a B5G-aided quality test system in advanced manufacturing, where various sensors are connected to the base station (BS) and send contextual information via mMTC. The BS and quality test machine transmit short length commands and small size feedback to each other, respectively, via URLLC. We formulate a long-term optimization problem to improve the product qualification rate by maximizing the expected average reward with limited testing capacity and changing configurations. To address this problem, we develop a novel context-aware combinatorial quality test (CC-QT) algorithm based on bandit learning (BL), which integrates contextual information to predict the product quality, and a combinatorial method to decrease the complexity of the BL process. Furthermore, we derive a performance upper bound of the proposed CC-QT and analyze its computational complexity. Experimental results illustrate the performance of CC-QT and substantiate its superiority over the existing algorithms.
Regulated Expression of Nuclear Protein(s) in Myogenic Cells- That Binds to a Conserved 3′ Untranslated Region in Proαl(I) Collagen cDNA (1989)

We describe the identification and DNA-binding properties of nuclear proteins from rat L6 myoblasts which recognize an interspecies conserved 3' untranslated segment of pro alpha 1 (I) collagen cDNA. Levels of the two pro alpha 1 (I) collagen RNAs, present in L6 myoblasts, decreased drastically between 54 and 75 h after induction of myotube formation in serum-free medium. Both mRNAs contained a conserved sequence segment of 135 nucleotides (termed tame sequence) in the 3' untranslated region that had 96% homology to the human and murine pro alpha 1 (I) collagen genes. The cDNA of this tame sequence was specifically recognized by nuclear protein(s) from L6 myoblasts, as judged by gel retardation assays and DNase I footprints. The tame-binding protein(s) was able to recognize its target sequence on double-stranded DNA but bound also to the appropriate single-stranded oligonucleotide. Protein that bound to the tame sequence was undetectable in nuclear extracts of L6 myotubes that did not accumulate the two collagen mRNAs. Therefore, the activity of this nuclear protein seems to be linked to accumulation of the sequences that it recognizes in vitro. The collagen RNAs and the nuclear tame-binding proteins reappeared after a change of medium, which further suggests that the RNAs and the protein(s) are coordinately regulated.
Malate synthase expression is deregulated in the Pseudomonas aeruginosa cystic fibrosis isolate FRD1 (2011)

Pseudomonas aeruginosa causes chronic pulmonary infections, which can persist for decades, in patients with cystic fibrosis (CF). Current evidence suggests that the glyoxylate pathway is an important metabolic pathway for P. aeruginosa growing within the CF lung. In this study, we identified glcB, which encodes for the second key enzyme of the glyoxylate pathway, malate synthase, as a requirement for virulence of P. aeruginosa on alfalfa seedlings. While expression of glcB in PAO1, an acute isolate of P. aeruginosa, responds to some carbon sources that use the glyoxylate pathway, expression of glcB in FRD1, a CF isolate, is constitutively upregulated. Malate synthase activity is moderately affected by glcB expression and is nearly constitutive in both backgrounds, with slightly higher activity in FRD1 than in PAO1. In addition, RpoN negatively regulates glcB in PAO1 but not in FRD1. In summary, the genes encoding for the glyoxylate-specific enzymes appear to be coordinately regulated, even though they are not located within the same operon on the P. aeruginosa genome. Furthermore, both genes encoding for the glyoxylate enzymes can become deregulated during adaptation of the bacterium to the CF lung.
Nanoparticle Coatings for UV Protective Textiles (2010)

Abstract TAs the intensity of ultraviolet (UV) radiation increases every year, effective methods to block UV rays to protect human skin, plastics, timber and other polymer materials are urgently sought. Textiles serve as important materials for UV protection in many applications. The utilisation of nanoparticles to textile materials has been the object of several studies aimed at producing finished fabrics with different performances. This article reviews the recent advancements in the field of UV blocking textiles and fibers that are functionalised with nanostructured surface coatings. Different types of UV blocking agents are discussed and various examples of UV blocking textiles that utilise zinc oxide (ZnO) and titanium dioxide (TiO2) are presented. Future challenges, such as wash-fastness and photocatalysis, are also discussed.
Distribution of hexamethylbenzene in a zeolite studied by xenon-129 and multiple-quantum NMR (1987)

3 pages
Electrochemical behavior of Sn–graphene composite coating (2015)

The electrochemical properties of pure Sn and Sn–graphene composite coating have been determined and compared.
SYNTHESIS AND ANTICANCER ACTION OF NITRIC OXIDE-RELEASING LIPOSOMES (2019)

The implementation of nitric oxide (NO)-based therapeutics has been met with formidable challenges relating to NO’s gaseous, reactive nature and difficulties associated with controlled delivery. Although macromolecular vehicles have been developed for applications in NO release, a common limitation associated with these systems is exposure of the NO donor to the surrounding medium, resulting in unintended NO release. To overcome this issue, liposomes were investigated as new vehicles for NO delivery whereby the NO donor is encapsulated within the aqueous core, protected from the external solution by a lipid membrane. Liposomes with encapsulated N-diazeniumdiolate NO donors were first synthesized using a reverse-phase evaporation protocol. Encapsulation efficiencies for several molecular NO donors were in the range of 33–41%. Relative to the unencapsulated (free) NO donor, NO-release half-lives at pH 7.4 were up to 7-times greater upon encapsulation, yet the NO-releasing liposomes still exhibited their unique pH-sensitive release properties. The liposomes retained ~80% of the encapsulated NO concentrations after 3 months of storage at 4°C, indicating excellent stability. In order to determine if the liposomes held merit as therapeutic agents, cytotoxicity against human pancreatic cancer cells were performed that demonstrated the liposomal NO donors required less NO to kill versus the free NO donor (183 μM and 2.4 mM, respectively). The ability to tune NO-release kinetics of these liposomes was further studied. It was possible to vary the NO-release kinetics by altering the encapsulated NO donor molecule or the phospholipid composing the bilayer (independently or in combination). Phospholipid headgroup surface area was determined to be a main factor in controlling NO-release half-lives. As the surface area of the lipid headgroup was decreased from 0.660 nm2 to 0.420 nm2, a concomitant increase in NO-release half-life was also observed. The composition of the lipid bilayer is known to affect in vivo properties, so NO-release kinetics were also measured in serum and whole blood. Half-lives in serum were equivalent to those measured in buffer, while those measured in blood were ~60% faster. An investigation into the cytotoxicity of slow (t1/2 > 72 h) versus fast (t1/2 ~ 2.5 h) NO-releasing liposomes demonstrated how the biological consequences were dependent on the NO-release rate. Fast NO-releasing liposomes yielded consistently higher LD50 values (>230 μM NO), relative their slow-releasing counterparts (<230 μM NO), across 9 different cancer cell lines encompassing 3 different types of cancer (breast, colorectal, and pancreatic). The fast-release system was able to eradicate 50% of the cells much quicker (~36 h vs. 72 h for slow-release system). Flow cytometry studies suggest that this faster killing is due to a more rapid intracellular build-up of NO, which was observed for both the free and encapsulated NO donors. Western blotting revealed that both the slow and fast NO-release systems could induce apoptosis, albeit to different degrees.
Biopharmaceutical Process Optimization with Simulation and Scheduling Tools (2014)

Design and assessment activities associated with a biopharmaceutical process are performed at different levels of detail, based on the stage of development that the product is in. Preliminary "back-of-the envelope" assessments are performed early in the development lifecycle, whereas detailed design and evaluation are performed prior to the construction of a new facility. Both the preliminary and detailed design of integrated biopharmaceutical processes can be greatly assisted by the use of process simulators, discrete event simulators or finite capacity scheduling tools. This report describes the use of such tools for bioprocess development, design, and manufacturing. The report is divided into three sections. Section One provides introductory information and explains the purpose of bioprocess simulation. Section Two focuses on the detailed modeling of a single batch bioprocess that represents the manufacturing of a therapeutic monoclonal antibody (MAb). This type of analysis is typically performed by engineers engaged in the development and optimization of such processes. Section Three focuses on production planning and scheduling models for multiproduct plants.