gebhart/patrepeval huggingface dataset:
Coordinatively unsaturated cationic complexes of rhodium(I), iridium(I), palladium(II), and platinum(II). Generation, synthetic utility, and some catalytic studies (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoordinatively unsaturated cationic complexes of rhodium(I), iridium(I), palladium(II), and platinum(II). Generation, synthetic utility, and some catalytic studiesJohn A. Osborn and Richard R. SchrockCite this: J. Am. Chem. Soc. 1971, 93, 12, 3089–3091Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/ja00741a069https://doi.org/10.1021/ja00741a069research-articleACS PublicationsRequest reuse permissionsArticle Views1751Altmetric-Citations265LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of pharmacokinetics of NS-105, a novel agent for cerebrovascular disease, in elderly and young subjects. (1999)

Pharmacokinetics of NS-105, a novel agent for cerebrovascular disease, in elderly subjects were compared with those in younger subjects. Fourteen healthy male volunteers (7 elderly subjects aged 68-79 years and 7 young subjects aged 20-32 years) were included in the study. In a parallel group design, a tablet containing 100 mg NS-105 was administered orally after breakfast. One young subject was excluded from the pharmacokinetic analyses owing to an insufficient urine collection. The maximum plasma concentration (Cmax) was higher in the elderly (3.06 +/- 0.69 vs. 2.13 +/- 0.34 micrograms/ml, the elderly vs. the young, mean +/- SD, p = 0.0117) and area under the plasma concentration curve (AUC) was also higher in the elderly (24.6 +/- 4.4 vs. 14.4 +/- 3.1 micrograms.hr/ml, p = 0.0006). There is a tendency that time to reach Cmax was longer in the elderly (2.1 +/- 1.1 vs. 1.3 +/- 0.5 hr, p = 0.1199), and a tendency of prolongation of elimination half-life. Urinary recovery of NS-105 was less in the elderly up to 8 h after administration, while total recovery of the dose was not different in the two groups. Total clearance was reduced in the elderly (0.076 +/- 0.013 vs. 0.121 +/- 0.025l/kg/hr, p = 0.0013) and the decrease seemed to be mainly due to a decrement in renal clearance of the drug in the elderly. A significant correlation was found between renal clearance of NS-105 and creatinine clearance of each subject (r = 0.583, p = 0.0364). These observations indicate that the plasma concentration of NS-105 will increase in elderly subjects mainly due to a decrement in renal clearance of the drug. Careful observation is needed when prescribing the drug to an elderly patient.
Interaction of α-Synuclein with Negatively Charged Lipid Membranes Monitored by Surface Plasmon Resonance (2016)

Aggregation of presynaptic protein -synuclein is implicated in the development of Parkinson's disease. Interaction of -synuclein with lipid membranes appears to be critical for its physiological and pathological roles. Anionic lipids trigger conformational transition of synuclein from its natively disordered into an -helical structure. Here we used surface plasmon resonance (SPR) to determine the affinities of -synuclein for the small unilamellar vesicles composed of anionic 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) or 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol (DPPG) and neutral 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipids. -Synuclein bound in a concentration dependent manner to equimolar mixtures of POPC/POPS and POPC/DPPG vesicles. The affinity of -synuclein for POPC/POPS was ~3-fold higher than for POPC/DPPG. These results indicate that headgroup charge is not the only factor contributing to -synuclein-membrane association.
Scheduling real-time applications in an open environment (2002)

This paper extends the two-level hierarchical scheme in (Deng et al., 1997) for scheduling independently developed real-time applications with non-real-time applications in an open environment. The environment allows the schedulability of each real-time application to be validated independently of other applications in the system. The extended scheme removes the following two restrictions of the scheme: real-time applications that are scheduled preemptively must consist solely of periodic tasks; and applications must not share global resources (i.e., resources used by more than one application). Consequently, the extended scheme can accommodate a much broader spectrum of real-time applications.
Modeling of a highly reliable real-time distributed system using the RTO.k model and the monitor object (2002)

The main focus of this paper is the modeling of a highly reliable real-time distributed system using the RTO.k (Real-Time Object) model incorporating the monitor approach. The RTO.k model is used to specify the real-time distributed nature of the system, while the monitor is used to support reliable operations of the system. A monitor is an abstract software component to handle faults occurring during the system's operation. It can be modeled as an RTO.k object called a real-time monitor object (RTMO). In this paper, we present three basic structuring schemes with an RTO.k object and an RTMO. Our modeling approach utilizes these structuring schemes. To illustrate our approach, KODAS (KOrea Distribution Automation System), being developed at LG Industrial Systems Co. Ltd., is used. In order to examine the effectiveness of our approach, we have designed a simulation model for KODAS and implemented it on the DREAM kernel. The RTO.k model and the monitor approach can be easily incorporated, and can be integrated as a set of RTO.k objects so as to facilitate the modeling of a highly reliable real-time distributed system.
Increase in Activity During Calorie Restriction Requires Sirt1 (2005)

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.
EUV blank inspection (2008)

One of the major topics for the introduction of extreme ultraviolet (EUV) technology is the availability of defect-free
masks. From the mask makers' perspective, the quality of the incoming blank material is one of the key ingredients
impacting the yield of structured masks. Besides flatness and layer thickness uniformity, the number of defects
determines the final quality of the mask delivered to the customer for printing. Defects within the layers of optical blanks
have shown that they have a growing impact on the mask structuring process, well below the usual defect specifications
of the blanks. It is expected that this finding will also hold true for material layers above the multi-layer. In addition to
printing performance, EUV masks need to have a defect-free multi-layer. While this layer is easily accessible during
blank production, mask makers usually acquire the complete blank stacks with or without the coated resist. Incoming
blank inspection, therefore, must check the quality of the complete stack without destroying any of the functionality of
these layers. Siemens and AMTC have jointly developed a blank inspection tool that has been installed in AMTC's
Dresden facility and that allows the screening of an EUV blank under these boundary conditions. Previously,
SEMATECH successfully installed an M7360 from Lasertec in its Mask Blank Development Center (MBDC) in Albany,
NY, that shows much better sensitivity data than SEMATECH's earlier tool, the Lasertec M1350. This paper describes
the early performance of the Siemens DF-40XP on programmed multi-layer defect blanks and regular blanks and
compares it to that of the existing tools at the SEMATECH MBDC.
Gas phase chemistry of the 2-tert-butyl-3-phenylphosphirenylium cation: novel onium ions by nucleophilic attack at phosphorus and de novo P-spiro bicyclic phosphonium ions via [4 + 2+] cycloaddition with dienes (2002)

The 2-tert-butyl-3-phenylphosphirenylium ion 13 is formed in abundance in the gas phase from 1-chloro-1H-phosphirene 6 upon 70 eV electron ionization. Collision-induced dissociation (CID) and ion-molecule reactions followed by CID of the product ions were performed via pentaquadrupole mass spectrometry to probe the structure and reactivity of 13 towards representative nucleophiles and dienes. Under CID conditions, 13 produces a variety of fragment ions mainly via dissociation processes that are preceded by isomerizations. In ion-molecule reactions, 13 reacts readily with ethers, sulfides, pyridine and aniline to form hitherto unknown oxonium, sulfonium and azonium ions via nucleophilic attack at phosphorus. With butadiene, isoprene, 1-acetoxybutadiene, and with Danishefsky's diene (1-methoxy-3-silyloxybuta-1,3-diene), 13 undergoes [4 + 2+] cycloaddition at phosphorus to generate novel P-spiro bicyclic phosphonium ions. With butadiene and isoprene, a second [4 + 2] cycloaddition occurs which generates P-spiro tricyclic phosphonium ions. Whereas 13 also reacts readily with 1-acetoxybutadiene via[4 + 2+] cycloaddition, most of the nascent P-spiro cycloadducts are unstable and dissociate by the loss of either a neutral ketene or acetic acid molecule. B3LYP/6-31G(d,p) calculations were performed to gain insight into the structures of the product ions. The present study constitutes the first successful attempt to unravel the chemistry of 13, a unique 2 pi-Hückel phosphirenylium ion for which no direct solution chemical reactivity data are as yet available. The present findings also create a parallel with the solution reactivity of 1-halo-1H-phosphirenes and 1-triflato-1H-phosphirenes as precursors to phosphirenylium ions.
A New Molecular Switch Based on Helical Biladienone (2006)

A molecular field-effect switch (FES) employing zinc biladienone as the active element is reported (see figure). The switching mechanism is investigated and a new FES switching mechanism is proposed in which the molecules separate from the electrodes and their molecular orientation changes when a gate voltage is applied.
Modelling of the Formation of Non-Uniform Polymer Networks in Devices (2004)

Polymer Stabilised Liquid Crystal (PSLC) devices contain a polymer network (PN) formed from a liquid crystal host containing a low concentration of reactive liquid crystalline monomers. If a strongly UV absorbing liquid crystal is used, the UV intensity profile during polymerisation creates a non-uniformity in the polymerisation process and the final polymer distribution across the cell [1]. A theoretical model of the polymerisation process of the reactive mesogen molecules is presented which takes into account the UV intensity profile, the rate of polymerisation and molecular diffusion. The PN distribution has been calculated using realistic reaction parameters, diffusion constants and UV absorption coefficients for both a UV absorbing (E7) and a non-absorbing (ML1001) liquid crystal. SEM observations and optical microscopy were carried out and are found to support the numerical predictions.
Pigmentation in Intrinsically Aged Skin of A1 Guinea Pigs (2004)

It is known that skin often shows irregular pigmentation during aging which is frequently associated with hyperpigmentation. Many studies have utilized brownish A1 guinea pigs to investigate the pathogenesis of ultraviolet (UV)-induced skin pigmentation, however, changes associated with intrinsic aging in A1 guinea pig skin have not been documented. To characterize such changes, skin from the dorsal and neck areas of 20-week, 1-, 2-, 3- and 5-yr-old guinea pigs was examined. Skin color was measured using a colorimeter, and biopsy specimens were stained with Masson-Fontana, L-3,4-dihydroxyphenylalanine (DOPA), and antibodies against KIT (ACK-45), gp100 (HMB-45) and S-100 proteins. The L* value of skin color decreased with aging and melanin deposits increased in the epidermis. Further, DOPA+, gp100+ and S-100+ melanocytes increased, indicating that the number of melanocytes had increased with age, whereas KIT+ melanocytes did not increase in dorsal skin and actually decreased in neck skin with aging. Further, rippled pigmented areas appeared in the neck skin of the 3-yr-old animals, and in the dorsal and neck skin of 5-yr-old guinea pigs in the absence of UV irradiation. Melanocytes were distributed uniformly in younger skin, whereas they were clustered in older skin. UV irradiation caused an increase in the number of melanocytes, although they were not clustered. These results are the first to provide evidence that pigmentation is induced in the skin of intrinsically aged A1 guinea pigs in the absence of UV irradiation, a process that differs from that elicited by UV irradiation.
Cytologic features of adenoma malignum of the uterine cervix. (1999)

子宮頸部の悪性腺腫 (Adenomamalignum) における細胞像の診断的基準の確立を目的として検討を行った. 高分化型腺癌成分をほとんど含まない悪性腺腫8症例中再検討可能な5症例を対象とし,(1) 背景および出現部位,(2) 細胞集塊および配列,(3) 核および細胞質, の3項目について検討した. その結果,(1) 背景はきれいであったが黄色調の粘液がすべての部位に認められた.腫瘍細胞はC, Eスメアには認められたがVスメアにはほとんど認められなかった.(2) 大型シート状集塊, 全周性柵状配列を示す集塊, リボン状やぶどうの房状集塊などの出現を認めた.(3) 腫瘍細胞の細胞質には黄色調に染まる粘液を有していた. また核は類円形から楕円形で緊満感があり, クロマチンは微細顆粒状でeuchromatinの増加が示唆された.通常の鏡検時において1. きれいな背景に黄色調粘液の出現, 2. 黄色調粘液を有する丈の高い頸管腺細胞の集塊, 3-年齢 (高年齢) にそぐわない頸管腺細胞の出現とその量, 4. Cスメア標本に出現した頸管腺細胞の集塊, など4項目に示した所見のいずれかが認められた場合には, 上記の “悪性腺腫の特徴的細胞像” の (2),(3) と照らし合わせよく観察することにより診断可能であると思われた.
Thermodynamics of SU(2) gauge theory with dynamical, light fermions (1985)

Using microcanonical computer-simulation techniques we study the finite-temperature phase transitions in SU(2) gauge theory with four light-quark species. The chiral-symmetry-restoration transition is found by studying the order parameter 〈\ensuremath{\psi}\ifmmode\bar\else\textasciimacron\fi{}\ensuremath{\psi}〉. The theory's Wilson line, Wilson-line correlation function, and internal energies are measured in the vicinity of the transition. The Wilson line and its correlation function are smooth, apparently analytic functions of the physical temperature. These results are contrasted with their SU(3) counterparts.
AlxGa1−xAs intervalley scattering rates from field-assisted photoemission spectroscopy (1995)

Field-assisted photoemission has been observed from a semiconductor heterostructure with a GaAs-${\mathrm{Al}}_{0.25}$${\mathrm{Ga}}_{0.75}$As emitter layer and has yielded spectroscopic information on hot-electron energy distributions in the low-electron-density limit. Energy-distribution curves of electrons photoemitted from the structure under high electric fields have been measured as a function of electric field and photon energy. Computer-modeled values for the ${\mathrm{Al}}_{\mathit{x}}$${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$As intervalley coupling constants have been deduced as follows: ${\mathit{D}}_{\mathrm{\ensuremath{\Gamma}}\mathit{L}}$=(0.30\ifmmode\pm\else\textpm\fi{}0.10)\ifmmode\times\else\texttimes\fi{}${10}^{9}$ eV ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, ${\mathit{D}}_{\mathit{L}\mathit{L}}$=(0.70\ifmmode\pm\else\textpm\fi{}0.10)\ifmmode\times\else\texttimes\fi{}${10}^{9}$ eV ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, ${\mathit{D}}_{\mathit{X}\mathit{X}}$=(0.70\ifmmode\pm\else\textpm\fi{}0.05)\ifmmode\times\else\texttimes\fi{}${10}^{9}$ eV ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, ${\mathit{D}}_{\mathit{L}\mathit{X}}$=(0.70\ifmmode\pm\else\textpm\fi{}0.15)\ifmmode\times\else\texttimes\fi{}${10}^{9}$ eV ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, and ${\mathit{D}}_{\mathrm{\ensuremath{\Gamma}}\mathit{X}}$=(1.0\ifmmode\pm\else\textpm\fi{}0.2)\ifmmode\times\else\texttimes\fi{}${10}^{9}$ eV ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$.
Choked flow analogy for very low quality two-phase flows Technical report no. 18 (1966)

Choked flow analogy for very low quality two-phase flows - homogeneous flow and hydraulic jump theoretical models for predicting axial pressure distribution
Administration of Amiodarone During Resuscitation Is Associated with Higher Tumor Necrosis Factor-α Levels in the Early Postarrest Period in the Swine Model of Ischemic Ventricular Fibrillation (2013)

To compare the early postarrest inflammatory cytokine response between animals administered amiodarone (AMIO) and lidocaine (LIDO) intra-arrest during resuscitation from ventricular fibrillation (VF). Domestic swine (n=32) were placed under general anesthesia and instrumented before spontaneous VF was induced by balloon occlusion of the left anterior descending coronary artery. After 7 min of VF, standard ACLS resuscitation was performed and animals were randomized to either bolus AMIO (5 mg/kg, n=13) or LIDO (1 mg/kg, n=14) for recurrent or refractory VF. A non-antiarrhythmic (n=5) was also used for comparison. Following return of spontaneous circulation (ROSC), tumor necrosis factor (TNF)-α levels were drawn at 30 and 60 min. Groups were comparable with respect to prearrest hemodynamics and resuscitation variables. In the postarrest period, the LIDO and non-antiarrhythmic group demonstrated virtually identical TNF-α response trajectories. However, TNF-α levels were significantly higher in AMIO- than LIDO-treated animals at 30 min (geometric mean 539 versus 240 pg/mL, 2.2-fold higher, 95% confidence interval [CI] 1.3-3.8-fold higher, P=0.003) and at 60 min (geometric mean 570 versus 204 pg/mL, 2.8-fold higher, 95% CI 1.1-7.0-fold higher, P=0.03). Significant differences in the postarrest TNF-α levels were observed between animals treated with AMIO as compared to those treated with LIDO. Improved rates of ROSC seen with AMIO may come at the expense of a heightened proinflammatory state in the postcardiac arrest period.
Mutations in classical late infantile neuronal ceroid lipofuscinosis disrupt transport of tripeptidyl-peptidase I to lysosomes (2004)

Classical late infantile neuronal ceroid lipofuscinosis is an autosomal recessive disease caused by mutations in the CLN2 gene resulting in functional defects of the gene product tripeptidyl-peptidase I. This disease is associated with a progressive neurodegenerative course beginning at the age of two years with developmental stagnation, finally leading to a complete loss of motor function, vision and speech by the age of 10 years. We analyzed the functional consequences of the mutations R127Q, R208X, N286S, I287N, T353P and Q422H, which were previously identified in patients with late infantile ceroid lipofuscinosis, with regard to enzymatic activity, stability, post-translational processing and intracellular localization of tripeptidyl-peptidase I. We could not detect any translational product for the mutant R208X. We found that four missense mutations, N286S, I287N, T353P and Q422H, which are located in conserved protein regions of tripeptidyl-peptidase I, decreased the enzymatic activity dramatically, blocked processing to mature size peptidase and led to protein retention in the endoplasmatic reticulum and rapid degradation in non-lysosomal compartments. We conclude that these amino-acid substitutions induce major misfolding of the precursor peptidase and hence prevent post-translational processing and lysosomal targeting of tripeptidyl-peptidase I. In contrast, the amino-acid substitution R127Q within a non-conserved protein region did not significantly affect enzymatic activity, stability, processing and lysosomal targeting of tripetidyl-peptidase I. Thus, our functional analyses of CLN2 mutations reveal novel insight into the molecular defect underlying dysfunction of tripeptidyl-peptidase I.
RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data (2022)

Supplementary data are available at Bioinformatics online.
Kinetic Analysis of the Rearrangement of a Conformationally Constrained .alpha.-Cyclopropylbenzyl Radical (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic Analysis of the Rearrangement of a Conformationally Constrained .alpha.-Cyclopropylbenzyl RadicalHariharan Venkatesan and Marc M. GreenbergCite this: J. Org. Chem. 1994, 59, 13, 3514–3517Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/jo00092a003https://doi.org/10.1021/jo00092a003research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Targeted intracellular delivery of synergistic drug combinations: tackling drug resistance in human breast cancer (2015)

Tese de doutoramento em Ciências Farmacêuticas, no ramo de Tecnologia Farmacêutica, apresentada à Faculdade de Farmácia da Universidade de Coimbra
A Low Cost Inkjet-Printed Mass Sensor Using a Frequency Readout Strategy (2021)

The development of low-cost mass sensors is of unique interest for the scientific community due to the wide range of fields requiring these kind of devices. In this paper, a full inkjet-printed mass sensor is proposed. The device is based on a PolyEthylene Terephthalate (PET) cantilever beam (operating in its first natural frequency) where a strain-sensor and a planar coil have been realized by a low-cost InkJet Printing technology to implement the sensing and actuation strategies, respectively. The frequency readout strategy of the sensor presents several advantages, such as the intrinsic robustness against instabilities of the strain sensor, the residual stress of the cantilever beam, the target mass material, and the distance between the permanent magnet and the actuation coil (which changes as a function of the target mass values). However, the frictionless actuation mode represents another shortcoming of the sensor. The paper describes the sensor design, realization, and characterization while investigating its expected behavior by exploiting dedicate models. The working span of the device is 0-0.36 g while its resolution is in the order of 0.001 g, thus addressing a wide range of potential applications requiring very accurate mass measurements within a narrow operating range.