gebhart/patrepeval huggingface dataset:
S77 Modulatory effects of rheumatoid arthritis IGG on neutrophil activation: a potential role in RA-ILD (2016)

<h3>Background</h3> Rheumatoid arthritis (RA) is an autoimmune rheumatic disease (ARD) characterised by circulating autoantibodies, including anti-citrullinated protein antibodies (ACPA). Many RA patients have extra-articular disease, including ∼10% with interstitial lung disease (ILD). Risk factors for RA-ILD include: male sex; age; smoking history and ACPA positivity. <h3>Hypothesis</h3> We propose that RA-IgG, including ACPA, modulate neutrophil functions including: generation of reactive oxygen species (ROS), neutrophil adhesion and generation of neutrophil extracellular traps (NETs) that may contribute to joint and extra-articular tissue damage, including ILD. <h3>Methods</h3> Neutrophils and IgG were isolated from RA patients or healthy controls (HC). Bronchoalveolar lavage (BAL) was performed on ILD patients and controls underdoing bronchoscopy for other reasons. ROS production was measured using an enzymatic assay to assess hydrogen peroxide (H2O2) generation. Neutrophil integrins were quantified by flow cytometry. Effects of purified IgG upon neutrophil adhesion to immobilised fibrinogen (Mac-1/aMß2-dependent) and fibronectin (VLA-4/a4ß1-dependent) were determined using a fluorescent adhesion assay. NETosis was measured using a novel capture ELISA. <h3>Results</h3> We demonstrated increased NETs in the BAL of patients with active ILD (n = 3; ARD-ILD) compared to those with inactive disease (n = 2; IPF and ARD-ILD) or controls (n = 1; CLL). In addition, we showed binding of RA-IgG to control neutrophils, which increased with neutrophil activation. Stimulation of HC (n = 12) and RA (n = 7) neutrophils with PMA produced similar rates of H2O2 generation (p = 0.9939). Exposure of HC neutrophils to RA-IgG (n = 9) however, increased H2O2 production compared to HC-IgG (n = 9) (p &lt; 0.0001), which was not blocked by FcR blockade. RA-IgG also enhanced PMA-stimulated adhesion of HC neutrophils to fibrinogen (p = 0.0028) and fibronectin (p = 0.0024), which was inhibited by aMß2 or ß1 integrin blockade respectively. RA-IgG increased both spontaneous (p = 0.0248) and PMA-induced (p = 0.0200) NETosis of HC neutrophils compared to HC-IgG. Immunofluorescence studies demonstrate that aMß2 activation induces NETosis. Further examination found that NETosis could be suppressed by p38 MAPK inhibition (p = 0.0034). <h3>Conclusion</h3> We have shown that RA-IgG modulates several aspects of neutrophil activation and function. In addition, we found increased neutrophil activation in the lungs of patients with active ARD-ILD. Further work is underway to evaluate the contribution of these processes to the pathogenesis of RA-ILD.
Theoretical Analysis of Hybrid Plasmonic Waveguide (2013)

We investigate the properties of the modes supported by the hybrid plasmonic waveguide consisting of a metal surface separated from a high-index slab by a low-index spacer. We examine the variations of the effective mode indices and field profiles of the hybrid modes for various choices of waveguide dimensions. We show that the observed variations of the modal properties can be explained from the fact that these modes result from the coupling of the surface plasmons, supported by the metal-dielectric interface, and the dielectric waveguide mode, supported by the high-index slab. The method of analysis is very general and can be used to explain the modal properties of the hybrid plasmonic waveguides for a wide range of material properties and waveguide dimensions.
Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors (2017)

Situin 2 (SIRT2) enzyme is a histone deacetylase that has important role in neuronal development. SIRT2 is clinically validated target for neurodegenerative diseases and some cancers. In this study, exhaustive unsupervised pharmacophore modeling was combined with quantitative structure-activity relationship (QSAR) analysis to explore the structural requirements for potent SIRT2 inhibitors using 146 known SIRT2 ligands. A computational workflow that combines genetic function algorithm with k-nearest neighbor or multiple linear regression was implemented to build self-consistent and predictive QSAR models based on combinations of pharmacophores and physicochemical descriptors. Successful pharmacophores were complemented with exclusion spheres to optimize their receiver operating characteristic curve profiles. Optimal QSAR models and their associated pharmacophore hypotheses were experimentally validated by identification and in vitro evaluation of several new promising SIRT2 inhibitory leads retrieved from the National Cancer Institute structural database. The most potent hit illustrated IC<sub>50</sub> value of 5.4μM. The chemical structures of active hits were validated by proton nuclear magnetic resonance and mass spectroscopy.
Oral Bioavailability and Plasma Disposition of Pefloxacin in Healthy Broiler Chickens (2017)

The pharmacokinetics of pefloxacin after single 10 mg/kg BW intravenous (IV) and oral doses were studied in healthy broiler chickens. For 24 h, serial blood samples were obtained after IV and oral administration. Concentrations of pefloxacin and its major metabolite <i>N</i>-demethyl pefloxacin (norfloxacin) were measured by use of high-performance liquid chromatography. The plasma concentrations-time data were found to fit a two-compartment open model. For pefloxacin, the elimination half-life (<i>t</i><sub>½β</sub>) was 8.44 ± 0.48 and 13.18 ± 0.82 h after IV and oral administration, respectively. After single oral dose, pefloxacin was rapidly absorbed with an absorption half-life (<i>t</i><sub>½a</sub>) and <i>T</i><sub>MAX</sub> of 0.87 ± 0.07 and 2.01 ± 0.12 h, respectively. Maximum plasma concentration (<i>C</i><sub>MAX</sub>) was 4.02 ± 0.31 µg/mL. Oral bioavailability of pefloxacin was found to be 70 ± 2%. Pefloxacin was converted to <i>N</i>-demethyl pefloxacin (norfloxacin). This metabolite represented 5% of the parent drug plasma concentrations. The maximal plasma concentration (<i>C</i><sub>MAX</sub>) of <i>N</i>-demethyl pefloxacin (norfloxacin) was calculated as 0.19 ± 0.01 mg/mL. The <i>t</i><sub>½β</sub> of <i>N</i>-demethyl pefloxacin after oral pefloxacin administration was 10.93 ± 0.80 h. The results indicate that an oral dose of 10 mg pefloxacin/kg BW, every 24 h, should be effective in treatment of the most systemic infections in poultry.
ADVANCED HYDROGEN TRANSPORT MEMBRANES FOR VISION 21 FOSSIL FUEL PLANTS (2003)

Eltron Research Inc., and team members CoorsTek, Sued Chemie, and Argonne National Laboratory are developing an environmentally benign, inexpensive, and efficient method for separating hydrogen from gas mixtures produced during industrial processes, such as coal gasification. This project was motivated by the National Energy Technology Laboratory (NETL) Vision 21 initiative which seeks to economically eliminate environmental concerns associated with the use of fossil fuels. This objective is being pursued using dense membranes based in part on Eltron-patented ceramic materials with a demonstrated ability for proton and electron conduction. The technical goals are being addressed by modifying composite membrane composition and microstructure to maximize hydrogen permeation without loss of material stability. Ultimately, these materials must enable hydrogen separation at practical rates under ambient and high-pressure conditions, without deactivation in the presence of feedstream components such as carbon dioxide, water, and sulfur. During this quarter, a composite metal membrane based on an inexpensive hydrogen permeable metal achieved permeation rates in excess of 25 mL/min/cm{sup 2}. Preliminary attempts to incorporate this metal into a cermet were successful, and a thick cermet membrane (0.83 mm) with 40 vol.% metal phase achieved a permeation rate of nearly 0.4 mL/min/cm{sup 2}. Increasing the metal phase content and decreasing membrane thickness should significantly increase permeation, while maintaining the benefits derived from cermets. Two-phase ceramic/ceramic composite membranes had low hydrogen permeability, likely due to interdiffusion of constituents between the phases. However, these materials did demonstrate high resistance to corrosion, and might be good candidates for other composite membranes. Temperature-programmed reduction measurements indicated that model cermet materials absorbed 2.5 times as much hydrogen than the pure ceramic analogs. This characteristic, in addition to higher electron conductivity, likely explains the relatively high permeation for these cermets. Incorporation of catalysts with ceramics and cermets increased hydrogen uptake by 800 to more than 900%. Finally, new high-pressure seals were developed for cermet membranes that maintained a pressure differential of 250 psi. This result indicated that the approach for high-pressure seal development could be adapted for a range of compositions. Other items discussed in this report include mechanical testing, new proton conducting ceramics, supported thin films, and alkane to olefin conversion.
Separation of proteins by ammonium sulfate gradient solubilization (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation of proteins by ammonium sulfate gradient solubilizationT. P. KingCite this: Biochemistry 1972, 11, 3, 367–371Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://pubs.acs.org/doi/10.1021/bi00753a010https://doi.org/10.1021/bi00753a010research-articleACS PublicationsRequest reuse permissionsArticle Views2379Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Institutions in Channel Theory (2007)

SOCREAL 2007: International Workshop on Philosophy and Ethics of Social Reality. Sapporo, Japan, 2007-03-09/10. Session 2: Logical Dynamics of Social Interaction
The PurR regulon in Lactococcus lactis – transcriptional regulation of the purine nucleotide metabolism and translational machinery (2012)

Purine nucleotides are either synthesized de novo from 5-phosphoribosyl-1-pyrophosphate (PRPP) or salvaged from the environment. In Lactococcus lactis, transcription of the de novo synthesis operons, purCSQLF and purDEK, has genetically been shown to be activated by the PurR protein when bound to a conserved PurBox motif present on the DNA at a fixed distance from the promoter -10 element. PurR contains a PRPP-binding site, and activation occurs when the intracellular PRPP pool is high as a consequence of low exogenous purine nucleotide pools. By an iterative approach of bioinformatics searches and motif optimization, 21 PurR-regulated genes were identified and used in a redefinition of the PurBox consensus sequence. In the process a new motif, the double-PurBox, which is present in a number of promoters and contains two partly overlapping PurBox motifs, was established. Transcriptional fusions were used to analyse wild-type promoters and promoters with inactivating PurBox mutations to confirm the relevance of the PurBox motifs as PurR-binding sites. The promoters of several operons were shown to be devoid of any -35 sequence, and found to be completely dependent on PurR-mediated activation. This suggests that binding of the PurR protein to the PurBox takes over the role of the -35 sequence. The study has expanded the PurR regulon to include promoters in nucleotide metabolism, C(1) compound metabolism, phosphonate transport, pyrophosphatase activity, (p)ppGpp metabolism, and translation-related functions. Of special interest is the presence of PurBox motifs in rrn promoters, suggesting a novel connection between nucleotide availability and the translational machinery.
[A study of Nexin 1 of skin and hair follicle during postnatal development period of rat]. (1998)

These results suggested a possible role of Nexin 1 which was a potent serine-protease inhibitor and have been shown in many organs to play important roles in regulating cellular growth and differentiation in regulating hair follicular growth.
Undirectional Carbon Nanotube Yarn/Polymer Composites (2018)

Carbon nanotubes (CNTs) are one-dimensional nanomaterials with outstanding electrical and thermal conductivities and mechanical properties at the nanoscale. With these superior physical properties, CNTs are very attractive materials for future light weight structural aerospace applications. Recent manufacturing advances have led to the availability of bulk formats of CNTs such as yarns, tapes, and sheets in commercial quantities, thus enabling the development of macroscale composite processing methods for aerospace applications. The fabrication of unidirectional CNT yarn/polymer composites and the effect of processing parameters such as resin type, number of CNT yarn layers, CNT yarn/resin ratio, consolidation method, and tension applied during CNT yarn winding on the mechanical properties of unidirectional CNT yarn composites are reported herein. Structural morphologies, electrical and thermal conductivities, and mechanical performance of unidirectional CNT yarn/polymer composites under tensile and short beam shear loads are presented and discussed. The application of higher tension during the winding process and elevated cure pressure during the press molding step afforded a compact structural morphology and reduced void content in the composite. However, the composite tensile strength was negligibly impacted by the fabrication parameters, such as cure pressure, winding tension, and resin chemistry, excepting resin content and number of CNT yarn layers. The tension winding method produced better quality and lower resin content CNT yarn composites compared to conventional prepregging methods, resulting in higher specific strength and modulus of the composites. The specific tensile strength of the CNT composite was approximately 69 % of the starting CNT yarn. Electrical and thermal conductivities of unidirectional CNT yarn/polymer composites were in the range of 1000 to 12000 S/cm and 22 to 45 W/mK, respectively.
THE DEVELOPMENT OF LINKED STARTER BARS (1984)

A programme is described to test an interlocking bar system, developed as an alternative to rebending the starter bars in reinforced concrete as marketed by Square Grip. A series of links and interlocking bars, bent to shape code 39 are presented in a disposable polyurethene plank, which can be simply fixed to the face of the shuttering. After removing the shuttering and plastic plank, half of the linked bars are rotated into line and the connection subsequently encapsulated in concrete often at the intersection of two walls or a slab and wall. The main area of interest in the tests was the performance in direct tension. Initial cracking of the joint was found to be largely dependent on the quality of the concrete used and the preparation of the surfaces. The ultimate load carried is directly related to the area of reinforcing steel providing the links. The joint appears to function effectively after the appearance of a hair-line crack which largely disappears after the load is removed. Although the load-carrying capacity of the joint is good, deformation can be large. A design approach based on the results of the tests is outlined. (TRRL)
LSGO: Link State aware Geographic Opportunistic routing protocol for VANETs (2014)

Abstract Robust and efficient data delivery in vehicular ad hoc networks (VANETs) with high mobility is a challenging issue due to dynamic topology changes and unstable wireless links. The opportunistic routing protocols can improve the reliability of routing by making full use of the broadcast characteristics and assist in data transmission through additional backup links. In this paper, we propose a Link State aware Geographic Opportunistic routing protocol (LSGO) which exploits a combination of geographic location and the link state information as the routing metric. The LSGO aims to improve the reliability of data transmission in a highly dynamic environment, which selects the forwarders and prioritizes them based on the vehicle’s geographic location and the link’s quality. We compare the performance of LSGO with GpsrJ + which removes the unnecessary stop at a junction and greedy traffic aware routing protocol (GyTAR) using network simulator ns-2. The simulation results show that it opens more nodes to participate in the opportunistic data forwarding and increases a connection’s throughput while using no more network capacity than traditional routing. In the simulation, compared with other two protocols, when the number of vehicles and the average vehicle velocity increase, LSGO’s packet dropping rate is reduced and the network throughput is improved.
Travel in Virtual Reality (2019)

This chapter focuses on the most common use cases—where a user may be holding one or more virtual reality (VR) controllers each capable of detecting 6-degree of freedom motion, and typically equipped with at least a joystick and/or directional pad, and multiple buttons. Tele-Hop works by having a user point a virtual target at the destination and pressing a button. In most VR applications the target extends at the end of the VR controller/wand in an arc that intersects with the horizontal surface intended as the destination of the tele-hop. Waypoints are perhaps the easiest means of traveling in VR for the user. In the Omni-navigator scheme the user imagines that they are holding an airplane or bird in their hand and how they position and orient the bird determines how the user will navigate through the space.
Enantiomer-selektive Acetal-Bildung, ein Verfahren zur Reinherstellung bzw. Anreicherung von Enantiomeren (1986)

Dedoublement optique des racemiques de phenyl-1 alcanols-1 a l'aide de (perhydro trimethyl-8,9,9) methano-5,8 benzofurannol-2
Dispenser-printed planar thick-film thermoelectric energy generators (2011)

This work presents advancements in dispenser-printed thick film thermoelectric materials for the fabrication of planar and printable thermoelectric energy generators. The thermoelectric properties of the printed thermoelectric materials were measured as a function of temperature. The maximum dimensionless figures of merit (ZTs) at 302 K for the n-type Bi2Te3-epoxy composite and the p-type Sb2Te3-epoxy composite are 0.18 and 0.19, respectively. A 50-couple prototype with 5 mm × 640 µm × 90 µm printed element dimensions was fabricated on a polyimide substrate with evaporated metal contacts. The prototype device produced a power output of 10.5 µW at 61.3 µA and 171.6 mV for a temperature difference of 20 K resulting in a device areal power density of 75 µW cm−2.
Dopa‐responsive dystonia: [18F]dopa positron emission tomography (1991)

The syndrome of dopa-responsive dystonia comprises a minority of patients with dystonia, yet it is of considerable diagnostic importance because patients respond dramatically to L-dopa therapy. Benefits from this treatment are lasting, and the problems associated with long-term L-dopa therapy in patients with Parkinson's disease are generally absent. It has been suggested that this condition is due to a defect in the dopamine synthetic pathway, which is bypassed when patients are treated with L-dopa. We have studied [18F]dopa uptake in 6 patients with classic dopa-responsive dystonia (5 familial patients and 1 sporadic patient), aged 18 to 66 years. Data have been analyzed according to a graphic approach, calculating an influx constant for each region studied. We have also studied a seventh, clinically atypical, patient with juvenile dystonia-parkinsonism. Similar data have been calculated for a group of 10 healthy control subjects and 10 patients with Parkinson's disease. The 6 patients with typical dopa-responsive dystonia had a modest but significant reduction in the uptake of tracer into both caudate and putamen, which indicates a defect in the decarboxylation, vesicular uptake, and storage of [18F]dopa. This argues against the proposition that dopa-responsive dystonia is due to an inherited defect of tyrosine hydroxylase alone. In the atypical patient, however, we found a greater reduction of [18F]dopa uptake into both caudate and putamen, comparable with that in patients with Parkinson's disease.
Osteoconduction of a stoichiometric and bovine hydroxyapatite bilayer‐coated implant (2010)

The bilayer deposition technique supplies quick and long-term fixation of implants to bone, because the B-HA film dissolves to aid osteoconduction right immediately after implantation and the HA thin film maintains osteoconduction without dissolution. Neither of the thin-film fractures easily compared with thick coatings.
SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care (2020)

Abstract Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19). We obtained blood samples (n = 474) from hospitalized COVID-19 patients (n = 123), non-COVID-19 ICU sepsis patients (n = 25) and healthy controls (n = 30). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in plasma or serum (RNAemia) of COVID-19 ICU patients when neutralizing antibody response was low. RNAemia was associated with higher 28-day ICU mortality (hazard ratio [HR], 1.84 [95% CI, 1.22–2.77] adjusted for age and sex). In longitudinal comparisons, COVID-19 ICU patients had a distinct proteomic trajectory associated with RNAemia and mortality. Among COVID-19-enriched proteins, galectin-3 binding protein (LGALS3BP) and proteins of the complement system were identified as interaction partners of SARS-CoV-2 spike glycoprotein. Finally, machine learning identified ‘Age, RNAemia’ and ‘Age, pentraxin-3 (PTX3)’ as the best binary signatures associated with 28-day ICU mortality.
Actuation and Detection of a Nanoresonator by an Integrated Antiferro/Ferromagnetic Multilayer Stack (2009)

This paper presents a new actuation scheme at the nanoscale inherited from spintronics, which uses specific magnetic stacks retaining a high magnetization at the nanoscale. We have simulated a NEMS co-integrated with such a stack used as a nanomagnet and shown that the magnetic field in its vicinity is strong enough to actuate a nano-beam with the Lorentz force. This integrated nano-system has been fabricated, using a release process based on xeon difluorid, which allows obtaining gaps below 200 nm. Optical and electrical characterizations are under progress.