gebhart/patrepeval huggingface dataset:
Role of B-Lymphocyte Stimulator (BLyS) in Waldenstrom’s Macroglobulinemia. (2005)

Abstract Waldenstrom’s macroglobulinemia (WM) is a serious and frequently fatal disorder characterized by the production of a monoclonal IgM protein, a lymphoplasmacytic infiltrate in the bone marrow, and associated symptoms including anemia, lymphadenopathy and hyperviscosity. Many of the mechanisms leading to this disease are not yet known. It is clear, however, that there is dysregulation of the balance between cell proliferation and programmed cell death. BLyS (B-lymphocyte stimulator) is a TNF family member expressed by monocytes, neutrophils, macrophages, and dendritic cells. BLyS has been shown to be critical for maintenance of normal B cell development and homeostasis, and has been found to stimulate lymphocyte growth. BLyS is overexpressed in a variety of B-cell malignancies and has been shown to inhibit apoptosis in malignant B-cells. Studies of the effects of BLyS on B cell physiology have shown that it also regulates immunoglobulin secretion. In previous work, we have shown that malignant B cells from patients with WM are able to bind soluble BLyS and variably express the BLyS receptors, BAFF-R, TACI and BCMA. We also found expression of BLyS in bone marrow specimens by immunohistochemistry and elevated serum BLyS levels in patients with WM. The goal of this study was to determine the functional role of BLyS-receptor ligand system in Waldenstrom’s macroglobulinemia and its relevance to the increased immunoglobulin production seen in this disease. Using cells from WM patients, we first examined the ability of BLyS to increase the secretion of IgM by malignant B cells. BLyS, alone or in combination with cytokines that induce plasmacytic differentiation and immunoglobulin production (IL-2, IL-6, IL-10 and IL-12), was found to increase IgM secretion by malignant B cells. Mean baseline IgM levels significantly increased in cells treated with BLyS (p=0.03), cytokines (p=0.0002) and a combination of BLyS and cytokines (p&lt;0.0001). We then determined the effect of BLyS on the survival of malignant B cells using Annexin-V/PI staining. Compared to cells cultured in media alone, BLyS was found to increase viability of malignant B cells from WM patients. Cell viability was normalized relative to the media-alone control and the median relative viability increased significantly compared to controls (median increase 41.2%; range 8 – 46%). Next, we examined the ability of BLyS to modulate cell proliferation using thymidine incorporation. Using WM patient samples, BLyS was found to significantly enhance the proliferation of malignant B cells (p=0.0002). Furthermore, addition of anti-Ig antibody further enhanced the ability of BLyS to promote the proliferation of malignant B cells (p&lt;0.0001). In summary, we have demonstrated that BLyS enhances IgM secretion by malignant B cells from patients with Waldenstrom’s macroglobulinemia. We have also demonstrated the ability of BLyS to enhance the survival and proliferation of malignant B cells. Strategies to inhibit BLyS may potentially have therapeutic efficacy in Waldenstrom’s macroglobulinemia.
Design and construction of a thermophotovoltaic generator using turbine combustion gas (1997)

This US Naval Academy project involves the development of a prototype thermophotovoltaic (TPV) generator that uses a General Electric T-58 helicopter gas turbine as the heat source. The goals of this project were to demonstrate the viability of using TPV and external combustion gases to generate electricity, and develop a system which could also be used for materials testing. The generator was modularly designed so that different materials could be tested at a later date. The combustion gas was tapped from the T-58's combustor through one of the two ignitor ports and extracted through a silicon carbide matrix ceramic composite tube into a similarly constructed ceramic composite radiant emitter. The ceramic radiant emitter is heated by the combustion gas via convection, and then serves the TPV generator by radiating the heat outwards where it can be absorbed by thermophotovoltaic cells and converted directly into electricity. The gas turbine and generator module are monitored by a data acquisition system that performs both data collection and control functions. This paper details the design of the TPV generator. It also gives results of initial tests with the gas turbine.
Nuclear Magnetic Resonance (2010)

1National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland 2 School of Chemical Sciences, Dublin City University, Dublin 9, Ireland 3REQUIMTE, Department of Chemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal 4 School of Nursing, Dublin City University, Dublin 9, Ireland 5Department of Chemistry, Masaryk University, 611 37 Brno, Czech Republic
<title>Hierarchical approach to feature indexing</title> (1992)

We extend our previous approach to 2-D shape indexing, data-driven indexed hypotheses, to hierarchical features. It is shown mathematically and experimentally that an index based on hierarchical features is more computationally efficient than one based on nonhierarchical features. Our approach addresses two types of hierarchies: a multilevel approximation of the contours of 2-D objects and a three-level feature indexing system. Our approach can easily be extended to 3-D objects. As we know, occluded object recognition should be based on local features. However, these features may sometimes be lost due to changes of scale as well as to occlusion. Our first hierarchical mechanism is used to complement the feature loss due to scale changes. It results in multilevel approximations of the contours of objects using scale-space approaches. This approach is also beneficial when there are few boundary points of maximal curvature so that standard polygonal approximation schemes don''t work very well. Our second hierarchical mechanism is to use sets of visible local features to hypothesize the presence of objects. Verification of the various hypotheses is done via normalization and boundary template matching. Using these two hierarchical mechanisms results in an approach to shape recognition which is very general in practice. Theoretically, many types of features can be recognized, though line features are preferred. Our technique offers a new approach to the construction of indexing systems for image databases on the basis of image features.
Enhancement of Thermal Smoothing Effect on Laser Imprint with Soft X-Ray Radiation (2001)

The initial imprint of mass perturbation due to spatial nonuniformity of laser intensity is one of the most important issues in laser fusion research. Several imprint mitigation schemes by the use of soft X-ray radiation have been proposed to enhance the thermal smoothing effect within the conduction region. One of the schemes uses external X-ray irradiation prior to laser incidence to produce preformed plasma. Another has a low-density foam layer and high-Z material to heat the foam radiatively and make it uniform in density.
Iron Oxide Deposition on Heated Surfaces in Pressurized Boiling Water (1979)

AbstractThe deposition of suspended iron oxide in water at a 10-atm pressure during nucleate boilings on a Zircaloy heated surface has been studied. The effects of pressure on the deposition rate during the initial period have been investigated.The previously proposed iron oxide deposition model, based on the microlayer evaporation and dryout phenomena that occur in the nucleate boiling bubble at atmospheric pressure, is extended to high-pressure nucleate boiling conditions. The model is shown to be applicable for high-pressure studies.
Stem cell properties of human clonal salivary gland stem cells are enhanced by three-dimensional priming culture in nanofibrous microwells (2018)

The 3D spheroid culture of SGSCs in nanofibrous microwells promotes stem cell properties via activation of Wnt signaling. This may contribute to SGSC priming prior to regenerative therapy to restore salivary hypofunction after radiotherapy.
Cover Image, Volume 31, Issue 11 (2021)

The cover image is based on the Research Article Direct synaptic excitation between hilar mossy cells revealed with a targeted voltage sensor by Yihe Ma et al., https://doi.org/10.1002/hipo.23386.
ADSORPTIVE REMOVAL OF TRACE CONCENTRATION OF FLUORIDE FROM WATER USING CERIUM LOADED DRIED ORANGE JUICE RESIDUE (2018)

Two adsorbents for fluoride ion removal were developed from dried orange juice residue (DOJR) after loading Ce(III) and Ce(IV) in this study. The characterization of adsorbents was done by an energy dispersive X-ray spectroscopy, X-ray diffraction analysis, electron microscopy and chemical analysis. The experimental results indicated that the fluoride removal efficiency of both the adsorbents was influenced significantly by pH and the optimum operating pH was found to be 4. The equilibrium data were well fitted with Langmuir isotherm model and the maximum adsorption capacity of Ce(III)-DOJR and Ce(IV)-DOJR for fluoride were evaluated to be 0.67 and 1.22 mmol/g, respectively. Leakage of cerium from Ce(IV)-DOJR was negligible for trace concentration of fluoride but it was significant for high concentration of fluoride at pH below 3 resulting fluoride precipitation. Therefore, cerium-loaded DOJR investigated in this study can be considered as an efficient, environmentally benign and promising alternative for the treatment of fluoride contaminated with trace amount of fluoride ion.
Solving P2P Traffic Identification Problems Via Optimized Support Vector Machines (2007)

Since the emergence of peer-to-peer (P2P) networking in the last 90s, P2P traffic has become one of the most significant portions of the network traffic. Accurate identification of P2P traffic makes great sense for efficient network management and reasonable utility of network resources. Application level classification of P2P traffic, especially without payload feature detection, is still a challenging problem. This paper proposes a new method for P2P traffic identification and application level classification, which merely uses transport layer information. The method uses Support Vector Machines which have been optimized for performing large learning tasks, rendering that this method become more suitable for large network traffic. The experimental results show that this method achieved high efficiency and is suitable for real-time identification. And carefully tuning the parameters could make the method achieve high accuracy.
Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression (2004)

It is widely believed that long-term depression (LTD) and its counterpart, long-term potentiation (LTP), involve mechanisms that are crucial for learning and memory. However, LTD is difficult to induce in adult cortex for reasons that are not known. Here we show that LTD can be readily induced in adult cortex by the activation of NMDA receptors (NMDARs), after inhibition of glutamate uptake. Interestingly there is no need to activate synaptic NMDARs to induce this LTD, suggesting that LTD is triggered primarily by extrasynaptic NMDA receptors. We also find that de novo LTD requires the activation of NR2B-containing NMDAR, whereas LTP requires activation of NR2A-containing NMDARs. Surprisingly another form of LTD, depotentiation, requires activation of NR2A-containing NMDARs. Therefore, NMDARs with different synaptic locations and subunit compositions are involved in various forms of synaptic plasticity in adult cortex.
Scanning Tunneling Spectroscopy of Dangling-Bond Wires Fabricated on the Si(100)–2×1–H Surface (1997)

Tunneling spectroscopy of atomic-scale dangling-bond wires on a hydrogen-terminated Si(100)–2×1–H surface is studied using ultrahigh-vacuum scanning tunneling microscopy. Individual dangling bonds are fabricated by extracting hydrogen atoms one by one from the hydrogen terminated surface to form atomic-scale dangling-bond wires. These wires show a finite density of states at the Fermi level and do not show semiconductive band gaps. The results are compared with first-principles theoretical calculations.
1126. The actions of halogens on phosphine-substituted group VI metal carbonyls. Part II. A novel synthesis of some phosphine oxide complexes (1965)

J. Lewis and R. Whyman, J. Chem. Soc., 1965, 6027 DOI: 10.1039/JR9650006027
Biological and Medical Applications of Near-Infrared Spectrometry (1996)

Near-infrared spectrometry is being applied in the solution of problems in many areas of biomedical and pharmaceutical research, including cardiovascular radiology, brain imaging, formulation, quality/process control, and even clinical trials. The technique can also play a role in the biotechnology industry in the nondestructive analysis of small quantities of expensive materials. This report first defines near-IR spectrometry and imaging and then describes its application to atherosclerosis and stroke research. New developments in near-IR optics and instrumentation that make effective biomedical near-IR spectrometry possible are related, and, finally, new computational research results in parallel supercomputing for near-IR imaging are described. Together, instrumentation, optics, and computing combine to poise biomedical near-IR spectrometry for great advances as it enters the next century.
Supplementary Figure 1 from BRAF Inhibitor Vemurafenib Improves the Antitumor Activity of Adoptive Cell Immunotherapy (2023)

&lt;p&gt;PDF file - 117K, Analysis of melanoma-like genome-wide DNA copy number alterations in the SM1 cell line&lt;/p&gt;
Perception-oriented cooperation for multiple UAVs in a perception management framework: System concept and first results (2016)

This article presents a concept for Multi-UAV cooperation in manned-unmanned teaming (MUM-T) helicopter missions, embedded in military search & rescue operations. Due to their highly-dynamic nature, these kinds of missions are especially challenging. Thus, it is necessary for the UAVs to perform complex reconnaissance tasks in a semiautonomous manner. As these tasks are per se driven by their perceptive demands, the UAV automation should incorporate the specific constraints and limitations of its mission sensor & perception suite when conducting such missions. The perception-oriented cooperation of multiple UAVs offers a promising way to overcome these limitations, allowing to benefit from heterogeneous payload setups as well as from varying platform characteristics. In this paper, we present the concept and prototype of the Perception-Oriented Cooperation Agent (POCA), offering capabilities for the perceptive cooperation of multiple UAVs conducting complex reconnaissance missions. An integrated Multi-UAV perception planning & scheduling agent is described, specifically taking into account the informative needs of the H/C crew in control and the requirements of the mission sensor suite. The prototype of the planner is tested in three reduced toy problem setups, demonstrating it's Multi-UAV scheduling capabilities in different payload configurations.
Safety, Efficacy, and Immunogenicity of 2 Doses of Bovine‐Human (UK) and Rhesus–Rhesus‐Human Rotavirus Reassortant Tetravalent Vaccines in Finnish Children (2006)

BRV-TV vaccine is a promising new candidate rotavirus vaccine, with low reactogenicity and high efficacy. Two doses of BRV-TV or RRV-TV vaccine are sufficient for the induction of protection against severe rotavirus disease.
3D models over the centuries: From old floor plans to 3D representation (2014)

This paper presents a set of algorithms dedicated to the 3D modeling of historical buildings from a collection of old architecture plans, including floor plans, elevations and cutoffs. Image processing algorithms help to detect and localize main structures of the building from the floor plans (thick and thin walls, openings). The extrusion of the walls allow us to build a first 3D model. We compute height informations and add textures to the model by analyzing the elevation images from the same collection of documents. We applied this pipeline to XVIII <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> century plans of the Château de Versailles, and show results for two different parts of the Château.
On the design and performance of a power electronics converter for the DeepWind project (2019)

DeepWind is a vertical axis wind turbine (VAWT) concept, with the turbine rotor mounted on a floating spar buoy with the generator at the bottom up to 300 m below the sea. To control the starting, variable speed and overspeed limitation operation of the VAWT, the only method available is to control the torque and speed of the generator. A four quadrant, three level, neutral point clamped inverter configuration is proposed and the design of this discussed. Various operational features are tested on a small scale laboratory version. Sample test results are given. The challenges of the DeepWind marine application are presented and discussed and some solutions are proposed.
Promoter-dependent nuclear RNA degradation ensures cell cycle-specific gene expression (2019)

Cell cycle progression depends on phase-specific gene expression. Here we show that the nuclear RNA degradation machinery plays a lead role in promoting cell cycle-dependent gene expression by triggering promoter-dependent co-transcriptional RNA degradation. Single molecule quantification of RNA abundance in different phases of the cell cycle indicates that relative curtailment of gene expression in certain phases is attained even when transcription is not completely inhibited. When nuclear ribonucleases are deleted, transcription of the <i>Saccharomyces cerevisiae</i> G1-specific axial budding gene <i>AXL2</i> is detected throughout the cell cycle and its phase-specific expression is lost. Promoter replacement abolished cell cycle-dependent RNA degradation and rendered the RNA insensitive to the deletion of nuclear ribonucleases. Together the data reveal a model of gene regulation whereby RNA abundance is controlled by promoter-dependent induction of RNA degradation.
Effect of alpha-adrenergic blockade on exercise-induced asthma and conditioned cold air. (1984)

Cooling and drying of the intrapulmonary airways have been shown to be important stimuli for the development of bronchospasm induced by exercise and isocapnic cold air hyperventilation. It has also been suggested that alpha-adrenergic receptor activity is increased at lower temperatures. To evaluate the role of alpha-adrenergic activity in the development of bronchoconstriction during airway cooling, we examined the effects of alpha-adrenergic blockade with phentolamine on bronchospasm induced by exercise and isocapnic cold air hyperventilation in 8 asthmatics. Exercise consisted of 6 min of steady-state exercise at 90% predicted maximal heart rate breathing compressed air at 0% humidity and 21 +/- 1 degrees C (mean +/- SD). During baseline exercise studies, FEV1 fell 41.6 +/- 15.8%, but only 12.8 +/- 8.5% during alpha-adrenergic blockade (p less than 0.001). Isocapnic cold air challenge consisted of breathing compressed cold air (0% humidity, -17 +/- 4 degrees C) for 3-min periods, with stepwise increases in minute ventilation (Ve) until the FEV1 fell at least 20%. During baseline cold air challenges, FEV1 fell 20% (PD20 FEV1) at a Ve of 48.8 +/- 21 L/min. However, during alpha-adrenergic blockade 6 asthmatics were able to achieve much higher levels of VE (86.6 +/- 22.7 L/min) before FEV1 fell 20% (p less than 0.01), and 2 asthmatics did not decrease their FEV1 by 20%, despite reaching maximal levels of ventilation of 132 and 108 L/min, respectively. Alpha-adrenergic blockade did not affect airways responses to histamine or ragweed antigen (p greater than 0.1).(ABSTRACT TRUNCATED AT 250 WORDS)
Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26. (1993)

A genetic map of highly polymorphic microsatellite markers spanning the von Hippel-Lindau region (VHL) of 3p25 was constructed using the CEPH reference pedigrees. A greater than 1000:1 odds map of pter-D3S1038-RAF1-D3S651-D3S656-D3S110- D3S1255-cen was found. Genotyping of six multigenerational VHL families showed the region surrounding the D3S1038 marker to be the most likely location for the VHL gene with a peak location score of 10.04 with VHL completely linked to D3S1038. These data provide an initial high resolution genetic map of this region; D3S1038 appears to be a highly polymorphic marker that should prove useful in the future for presymptomatic diagnosis.
TheAgrobacteriumDNA Transfer Complex (1997)

Abstract Agrobacterium tumefaciens elicits tumorous growths on plants by transforming plant cells with a segment of its own DNA. This trait led to development of Agrobacterium as a vector for genetic transformation of flowering plants. The transformation process is a unique mixture of several distinct steps, some of which are evolutionarily and functionally related to bacterial conjugation, and some of which converge with eukaryotic cellular processes. Recent work has advanced our understanding of each of these steps. The early reactions in the production of an ssDNA transfer intermediate (T-strand), mediated by the VirD1/D2 proteins, are chemically similar to formation of a relaxosome in bacterial conjugation. The T-strand is coated by the ssDNA binding protein VirE2; however, whether this binding occurs in the bacterium or in planta is disputed. VirB proteins, related to proteins for the conjugal transfer of DNA between bacteria, most likely form the transfer apparatus. VirD2, which remains covalently bound to the 5′ end of the T-strand, and VirE2 both localize to the nucleus of plant cells. VirE2 also mediates the nuclear accumulation of ssDNA but only when the protein is bound to the ssDNA. Genetically, VirD2 is required for faithful integration of the 5′ end and VirE2 for the 3′ end of the T-strand. The steps of the process currently under active investigation are the assembly of the export apparatus and the enzymology of integration.
A secure platform for peer-to-peer computing in the Internet (2003)

Peer-to-peer computing (P2P) draws growing interest as a new distributed computing paradigm for its potential to harness "edge" computers (e.g., PCs) and make their under-utilized resources available to each other. P2P based e-commerce on the Internet is of particular interest because of P2P's cost effectiveness and redundancy-induced dependability. Beneath the promising benefits lie daunting challenges of supporting security, reliability, resilience, and scalability. In particular, scalable discovery and secure transaction are of paramount importance due to the sheer size and the laissez,faire nature of the Internet. E-Speak is an e-services infrastructure where services advertise, discover, and interoperate each other in a dynamic and secure way. The E-Speak security adopts a multi-layered approach and builds a range of protection mechanisms on top of the Public Key Infrastructure. The E-Speak advertising services have a dynamic pluggable architecture and implement a scalable wide-area discovery based on distributed queries. We argue that E-Speak may be used as the common secure, scalable infrastructure for different multiple P2P applications.
Stereoselective Introduction of Oxygen Functionalities at the 11.BETA.-Position of Erythrinan Skeleton: Total Syntheses of (.+-.)-Erythristemine and (+)-Erythrartine. (1994)

Oxidation of 8-oxoerythrinan and 8-oxo-1, 7-cycloerythrinan derivatives with 2 mol eq of ceric ammonium nitrate in alcohols or acetic acid gave the corresponding 11β-alkoxy or acetoxy compounds in moderate yield. Thus, (±)-3, 3, 15, 16-tetramethoxy-1, 7-cycloerythrinan-2, 8-dione and (+)-erysotramidine gave the corresoponding 11β-methoxy and 11β-acetoxy derivatives on oxidation in methanol and in acetic acid, respectively. Those compounds were respectively converted into (±)-erythristemine and (+)-erythrartine in several steps, thus achieving the total synthesis of these alkaloids.