gebhart/patrepeval huggingface dataset:
Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo-controlled study (2019)

This project was funded in part with Federal funds from the Department of Health and Human Services; Office of the Assistant Secretary for Preparedness and Response; Biomedical Advanced Research and Development Authority (BARDA), under Contract No. HHSO100201500018C.
Cervical inlet patch-optical coherence tomography imaging and clinical significance (2012)

We demonstrate in situ evaluation of CIP microstructures using 3D-OCT, which may be a useful tool for future diagnosis and follow-up of patients with CIP.
N‐N pair effects on GaInNAs semiconductor optical amplifiers (2007)

Abstract We explore the effects of N‐N pairs on the amplifying properties of GaInNAs based Semiconductor Optical Amplifiers. The bandstructure of GaInNAs is calculated with the 3 band anti‐crossing model to account for the N‐N pairs for the conduction band and k · p theory for the valence bands. For the calculation of the GaInNAs amplifier properties we adopt a multi‐sectioning approach to the rate equation that accounts for amplified spontaneous emission. Based on these we discuss the merits of N‐N pairs for GaInNAs semiconductor optical amplifiers. (© 2007 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity (2022)

This manuscript provides a review focused on embryonic stem cell-based models and their place within the landscape of alternative developmental toxicity assays. Against the background of the principles of developmental toxicology, the wide diversity of alternative methods using pluripotent stem cells developed in this area over the past half century is reviewed. In order to provide an overview of available models, a systematic scoping review was conducted following a published protocol with inclusion criteria, which were applied to select the assays. Critical aspects including biological domain, readout endpoint, availability of standardized protocols, chemical domain, reproducibility and predictive power of each assay are described in detail, in order to review the applicability and limitations of the platform in general and progress moving forward to implementation. The horizon of innovative routes of promoting regulatory implementation of alternative methods is scanned, and recommendations for further work are given.
Acute flaccid neonatal paraplegia (1983)

<h3>Abstract</h3> Ageing is the primary risk factor for AD; however, there is a poor understanding of the biological mechanisms by which the ageing process contributes to the development of AD in some individuals, while others progress to advanced age with relatively little AD neuropathology. To halt the progression of AD, the preclinical stage of neurodegeneration (before the onset of clinical symptoms) is anticipated to be the more effective time point for applying potentially disease-modifying interventions in AD. The main objective of this study was to understand the age and disease related proteomic changes are detectable in plasma, based on retrospective analysis of longitudinal data and cross-sectional analyses of clinically diagnosed cases. We conducted an in-depth plasma proteomics analysis using intensive depletion of high-abundant plasma proteins using the Agilent multiple affinity removal liquid chromatography (LC) column-Human 14 (Hu14) followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS PAGE) technique. In this study, we have begun to address the following questions; (1) differences in plasma proteomic profiles between normal ageing, vs ageing with progress to cognitive decline (MCI) or disease (dementia, probable AD), (2) cross-sectional analysis of baseline data, when all subjects are clinically identified as cognitively normal, provides insight into the preclinical changes which precede subsequent progression to AD and potentially provide early biomarkers, and (3) comparison of plasma at the point of progression to clinically diagnosed onset of cognitive decline or AD, can provide potential plasma biomarkers to facilitate clinical diagnosis. Furthermore, our findings also identified some proteins previously discovered in AD CSF and brain proteomics signatures that could provide clinically meaningful information. We identified differentially expressed proteins which were associated with several biological and molecular processes that may serve as therapeutic targets and fluid biomarkers for the disease.
A 750MHz 144Mb cache DRAM LSI with speed scalable design and programmable at-speed function-array BIST (2003)

A 750MHz 144Mb cache DRAM LSI incorporates speed-scalable embedded DRAM and SRAM macros, and is realized using a logic-merged DRAM process. The LSI has a built-in at-speed test engine with programmable test pattern and timing, merging logic and memory test. The die area is 285mm/sup 2/ in a 0.18/spl mu/m 6M logic-merged DRAM process.
Large Exchange Coupling in Synthetic Antiferromagnet With Ultrathin Seed Layer (2006)

Insertion of an ultrathin (les6 Aring) Ta-seed layer into the bottom NiFe layer of a synthetic antiferromagnet (SAF) grown on the AlO and MgO barriers of magnetic tunnel junctions (MTJs) significantly increased the crystal orientation of the SAF. This led to improvements of the strength and thermal robustness of the antiferromagnetic coupling (AFC) in the SAF. The magnetic properties of the films and MTJs using the SAFs were investigated. A low anisotropy field with a large AFC of the Ta-seed SAF reduced the writing field of toggle MRAMs
Antimicrobial Properties of Basil and Its Possible Application in Food Packaging (2003)

Basil (Ocimum basilicum L.) is a popular culinary herb, and its essential oils have been used extensively for many years in food products, perfumery, and dental and oral products. Basil essential oils and their principal constituents were found to exhibit antimicrobial activity against a wide range of Gram-negative and Gram-positive bacteria, yeast, and mold. The present paper reviews primarily the topic of basil essential oils with regards to their chemical composition, their effect on microorganisms, the test methods for antimicrobial activity determination, and their possible future use in food preservation or as the active (antimicrobial), slow release, component of an active package.
Quantitative analysis of three phases of high-density polyethylene with 2D time-domain proton NMR (1997)

With two-dimensional time-domain NMR analysis in the proton spin rotating frame, three phases are identifiable in the solid polyethylene. The major proton magnetization fraction is due to the polymer's crystalline region, where the motion is least isotropic and slowest. A magnetization fraction with intermediate relaxation rate is also intermediate in magnitude. This component is proposed to comprise chain loops on the surfaces of crystallites and effectively entangled chain segments. The most mobile fraction, which is most liquid-like with a T2 of near 1 ms at 120°C, is also the smallest. It is proposed that it is due to polymer chains in the amorphous phase. In the crystalline phase the chain motion is an unexpectedly effective relaxation mechanism at ∼50 KHz. This process, which involves propagation of a twisted region along the crystallite, as has been suggested before, is either not present in the other two phases of the HDPE or is less efficient because of the lower polymer density. The activation energies for the crystalline, intermediate and amorphous phases are estimated to be 34 ± 3, 13 ± 3, and 8 ± 2 Kcal/mol, respectively. The frequencies of the relaxation process at 120°C are 43 KHz, 350 KHz, and 1.5 MHz, respectively. © 1997 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 35: 2551–2558, 1997
A New Approach to the Control of Esophageal Stenosis (1972)

DAVIS, WILLIAM M. M.D.; MADDEN, JOHN W. M.D.; PEACOCK, ERLE E. JR. M.D. Author Information
Design of New Organic Gelators Stabilized by a Host−Guest Interaction (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTDesign of New Organic Gelators Stabilized by a Host−Guest InteractionKazuhiko Inoue, Yoshiyuki Ono, Yasumasa Kanekiyo, Tsutomu Ishi-i, Kanami Yoshihara, and Seiji ShinkaiView Author Information Chemotransfiguration Project, Japan Science and Technology Corporation (JST), 2432 Aikawa, Kurume, Fukuoka 839-0861, Japan Cite this: J. Org. Chem. 1999, 64, 8, 2933–2937Publication Date (Web):March 19, 1999Publication History Received1 September 1998Published online19 March 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/jo981786ahttps://doi.org/10.1021/jo981786abrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views613Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Gelation,Hydrocarbons,Molecular interactions,Solvents Get e-Alerts
Optimal architecture for diamond-based wide-field thermal imaging (2020)

Nitrogen-vacancy centers in diamonds possess an electronic spin resonance that strongly depends on temperature, which makes them efficient temperature sensors with sensitivity down to a few mK/Hz. However, the high thermal conductivity of the host diamond may strongly damp any temperature variations, leading to invasive measurements when probing local temperature distributions. In the view of determining possible and optimal configurations for diamond-based wide-field thermal imaging, here, we investigate both experimentally and numerically the effect of the presence of diamonds on microscale temperature distributions. Three geometrical configurations are studied: a bulk diamond substrate, a thin diamond layer bonded on quartz, and diamond nanoparticles dispersed on quartz. We show that the use of bulk diamond substrates for thermal imaging is highly invasive in the sense that it prevents any substantial temperature increase. Conversely, thin diamond layers partly solve this issue and could provide a possible alternative for microscale thermal imaging. Dispersions of diamond nanoparticles throughout the sample appear as the most relevant approach as they do not affect the temperature distribution, although NV centers in nanodiamonds yield lower temperature sensitivities than bulk diamonds.
3D‐Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia (2021)

Osteoarthritis of the hip is a painful and debilitating condition commonly occurring in humans and dogs. One of the main causes that leads to hip osteoarthritis is hip dysplasia. Although the current surgical methods to correct dysplasia work satisfactorily in many circumstances, these are associated with serious complications, tissue resorption, and degeneration. In this study, a one-step fabrication of a regenerative hip implant with a patient-specific design and load-bearing properties is reported. The regenerative hip implant is fabricated based on patient imaging files and by an extrusion assisted 3D printing process using a flexible, bone-inducing biomaterial. The novel implant can be fixed with metallic screws to host bone and can be loaded up to physiological loads without signs of critical permanent deformation or failure. Moreover, after exposing the hip implant to accelerated in vitro degradation, it is confirmed that it is still able to support physiological loads even after losing ≈40% of its initial mass. In addition, the osteopromotive properties of the novel hip implant is demonstrated as shown by an increased expression of osteonectin and osteocalcin by cultured human mesenchymal stem cells after 21 days. Overall, the proposed hip implant provides an innovative regenerative and mechanically stable solution for hip dysplasia treatment.
Neuropeptide precursors and acetylcholine receptor: molecular structures and gene expression (1984)

A new approach to the understanding of neural and hormonal peptides as well as neurotransmitter receptors has recently been provided by the application of recombinant DNA techniques. By cloning and sequencing cDNAs, we have elucidated the primary structures of three opioid peptide precursors and the corticotropin-releasing factor precursor (prepro-CRF) and of all four subunits of the nicotinic acetylcholine receptor (AChR). The genes encoding the neuropeptide precursors and the AChR subunits have also been isolated and characterized. The three opioid peptide precursors, that is, the corticotropin-β-lipotropin precursor (abbreviated as ACTH-β-LPH precursor; designated alternatively as prepro-opiomelanocortin), preproenkephalin A (also referred to as preproenkephalin) and preproenkephalin B (designated alternatively as prepro-dynorphin or prepronorphin), as well as their genes, exhibit strikingly similar structural organizations, apparently being evolutionarily related to one another.
Fiber-Optic Strain Sensors With Linear Characteristics (1993)

Fiber-optic modal domain strain sensors having linear characteristics over wide range of strains proposed. Conceived in effort to improve older fiber-optic strain sensors. Linearity obtained by appropriate choice of design parameters. Pattern of light and dark areas at output end of optical fiber produced by interference between electromagnetic modes in which laser beam propagates in fiber. Photodetector monitors intensity at one point in pattern.
Vergleich von Cochlea-Implantat-Magneten und ihrer MRT-Artefaktgröße (2020)

Abstract Einleitung: Jüngste Entwicklungen in Bezug auf Cochlea-Implantat-Magnete (z. B. bipolaren diametralen Magneten) und chirurgische Techniken (z. B. Implantatpositionierung) haben die Beziehung zwischen Cochlea-Implantaten und MRTerheblich beeinflusst und die Sichtbarkeit von Cochlea und vom inneren Gehörgang ermöglicht. Die MRT-Untersuchunghat sich von einer Kontraindikation zu einem Diagnosemittelgewandelt. Die Größe der Magnetartefakte spielt eine zentraleRolle bei der visuellen Beurteilung von Cochlea und vominneren Gehörgang.
Effects of Flow Rate on Dissolution of Monocrystal Alumina and Monocrystal Yttria-Stabilized Zirconia in High-Temperature Pure Water (2009)

The effects of flow rate on the dissolution of monocrystal alumina with an impurity of 0.003 wt% or monocrystal yttria-stabilized zirconia (YSZ) with an impurity of 0.08 wt% in high-temperature pure water were studied under the following conditions: temperature = 280°C; inlet electrical conductivity < 10 μS·m−1; flow rate = 0.002–2.6m·s−1; and dissolved oxygen concentration < 10 μg·kg−1. Alumina or YSZ is used as an inorganic insulant material from which the reference electrode is constructed to measure the electrochemical corrosion potential of structural materials used in boiling water reactors (BWRs). The weights per unit area of alumina specimens linearly decreased for 200 h. The apparent dissolution rate for a flow rate of 2.6m·s−1 (-0.80 g·m−2·h−1) was about 10 times as large as that for a flow rate of 0.002m·s−1 (-0.078 g·m−2·h−1). Assuming the equation, 1/Rr = 1/ks + 1/kd , where kd = α · K (Rr , apparent dissolution rate (g·m−2·h−1); ks , dissolution rate controlled by surface reaction (g·m−2·h−1); kd , dissolution rate controlled by diffusion of aluminum ion (g·m−2·h−1); K, mass transfer coefficient (m·s−1); α, constant (g·s·m−3·h−1)), dissolution rates controlled by surface reaction ks and constant α were calculated as −2:6 g·m−2·h−1, −633 g·s·m−3·h−1, respectively. The dissolution rate was thought to be controlled by the diffusion of aluminum from the surfaces to bulk water under the experimental conditions. The weight change was within the measurement limit for each flow rate for YSZ specimens. The specimens did not flake nor crack. The apparent dissolution rate was calculated as < 3.9 × 10−3 g·m−2·h−1 from the measurement limit, which was less than one-thousandth of that for alumina for the flow rate of 2.6 m·s−1. From these results, YSZ was judged as a more desirable material from the viewpoint of stability under BWR conditions.
Towards the understanding of vertical-axis wind turbines in double-rotor configuration. (2018)

Vertical-axis wind turbines (VAWTs) in double-rotor configuration, meaning two rotors in close proximity, have the ability to enhance the power performance. In this study, we work towards the understanding of vertical-axis wind turbines in double-rotor configuration. Numerical simulations are performed to gain insight in the physics behind the double-rotor concept. Furthermore, a parametric study is performed to explore the effect of the double-rotor lay-out, rotor loading, rotor spacing and wind direction on the flow characteristics and the power generation. Nomenclature c = Chord length [m] CP = Power coefficient [-] CT = Thrust coefficient [-] dint = Rotor spacing, D int/D [-] D = Rotor diameter, 2R [m] R = Rotor radius [m] V rel = Relative velocity [m/s] V = Incoming velocity [m/s] x = X-coordinate, X /D [-] y = Y-coordinate, Y /D [-] = Angle of attack [deg] = Azimuthal angle [deg] = Rotor solidity, N c /2R [-] = Tip speed ratio, R /V inf [-] = Rotational speed [rad/s]
Complications Associated with Fractured File Removal Using an Ultrasonic Technique (2005)

A technique utilizing modified Gates Glidden burs and ultrasonics has recently been advocated to remove fractured instruments from root canals. Varying extents of tooth structure are removed during this procedure, potentially leading to complications. This study evaluated the in vitro and in vivo complications associated with fractured file removal. Fractured instrument fragments were removed from three different levels (coronal, middle, or apical third) of mesiolingual canals of extracted human mandibular molars. The success rate, frequency of perforations, and root strength were recorded for each group. Perforations and unsuccessful file removal occurred only with fragments lodged in the apical third. Fracture resistance declined significantly with more apically located file fragments. A review of 60 clinical cases showed similar rates of successful file removal and rate of perforations. Removal of a fractured file fragment from the apical third of curved canals should not be routinely attempted.
Single-crystalline lead halide perovskite arrays for solar cells (2015)

Single-crystalline lead halide perovskite arrays have been successfully grown on a PEDOT:PSS coated ITO substrate by the droplet-pinned crystallization method and, for the first time, single-crystalline perovskite solar cells have been demonstrated.
Population Structure, Antimicrobial Resistance, and Mutation Frequencies of Streptococcus pneumoniae Isolates from Cystic Fibrosis Patients (2005)

Forty-eight Streptococcus pneumoniae isolates recovered from sputum samples from 26 cystic fibrosis (CF) patients attending our CF unit (1995 to 2003) were studied. Mean yearly incidence of isolation was 5.5%, and all were strains recovered from young patients (< or = 12 years). The isolation was linked to clinical exacerbation in 35% of the cases, but only 27% of these were not accompanied by other CF pathogens. Fifty percent of the patients presented with two to four isolates over the studied period. Pulsed-field gel electrophoresis-SmaI digestion revealed a high heterogeneity (32 pulsotypes among 48 isolates) and the persistence over a 6-month period of a single clone (clone A) in two patients. This clone, presenting a varied multiresistance phenotype, was identified as the Spain23F-1 clone and was also recognized in six other patients, including two out of nine patients from the CF unit of Sant Joan de Deu Hospital, Barcelona, Spain. In our isolates, 16 different serotypes were recognized, the most frequent being 23F (33.3%), 19F (18.8%), 6A (6.2%), and 6B (6.2%). High overall resistance rates were observed: to penicillin, 73%; to cefotaxime, 33%; to erythromycin, 42%; to tetracycline, 58%; to chloramphenicol, 48%; and to trimethoprim-sulfamethoxazole, 67%. Resistance to fluoroquinolones was not detected. Multiresistance was a common feature (60%). The percentage of S. pneumoniae strains with increased frequencies of mutation to rifampin resistance (> or = 7.5 x 10(-8)) was significantly higher (P = 0.02) in CF (60%) than among non-CF (37%) isolates in the same institution (M. I. Morosini et al., Antimicrob. Agents Chemother. 47:1464-1467, 2003). Even though a clear association with acute exacerbations could not be observed, long-term clonal persistence and variability, high frequency of antibiotic resistance, and hypermutability indicate the plasticity for adaptation of S. pneumoniae to the CF lung environment.
ATM Inhibition Sensitizes Tumors to High-Dose Irradiation (2019)

Mechanistic studies of high-dose irradiation are important to improve our understanding on how the efficacy of stereotactically delivered high-dose irradiation can be enhanced by therapeutics such as ataxia-telangiesctasia-mutated (ATM) inhibitors. In this issue of <i>Cancer Research</i>, Torok and colleagues found that a single 15 Gy radiation dose eliminated lung tumor growth in mice when ATM was deleted in cancer cells versus when deleted in endothelial cells. These data support the establishment of clinical trials testing ATM inhibitors in combination with highly conformal radiotherapy or high-dose rate brachytherapy.<i>See related article by Torok et al., p. 773</i>.
An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures (2007)

Reactive oxygen species (ROS) can damage proteins, cause lipid peroxidation, and react with DNA, ultimately resulting in harmful effects. Antioxidants constitute one of the defense systems used to neutralize pro-oxidants. Since pro-oxidants and antioxidants are found ubiquitously in nature, pro-and antioxidant effects of individual compounds and of mixtures receive much attention in scientific research. A major bottleneck in these studies, however, is the identification of the individual pro-oxidants and antioxidants in mixtures. Here, we describe the development and validation of an on-line post-column biochemical detection system for ROS-producing compounds and antioxidants in mixtures. Inclusion of cytochrome P450s and cytochrome P450 reductase also permitted the screening of compounds that need bioactivation to exert their ROS-producing properties. This pro-oxidant and antioxidant detection system was integrated on-line with gradient HPLC. The resulting high-resolution screening technology was able to separate mixtures of ROS-producing compounds and antioxidants, allowing each species to be characterized rapidly and sensitively.