gebhart/patrepeval huggingface dataset:
The Effect of Intranasal Fentanyl on the Emergence Characteristics After Sevoflurane Anesthesia in Children Undergoing Surgery for Bilateral Myringotomy Tube Placement (2001)

We examined the use of nasally administered fentanyl for the relief of agitation or discomfort after placement of bilateral myringotomy tubes in 150 children ages 6 mo to 5 yr using a prospective, double-blinded design. Fentanyl 2 microg/kg was found to reduce the incidence of agitation in these patients.
Influence of metformin on GLUT1 gene and protein expression in rat streptozotocindiabetes mellitusmodel (2010)

Metformin is prospective for treatment of diabetic nephropathy.
Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass (2003)

We have previously described osteoblast/osteocyte factor 45 (OF45), a novel bone-specific extracellular matrix protein, and demonstrated that its expression is tightly linked to mineralization and bone formation. In this report, we have cloned and characterized the mouse OF45 cDNA and genomic region. Mouse OF45 (also called MEPE) was similar to its rat orthologue in that its expression was increased during mineralization in osteoblast cultures and the protein was highly expressed within the osteocytes that are imbedded within bone. To further determine the role of OF45 in bone metabolism, we generated a targeted mouse line deficient in this protein. Ablation of OF45 resulted in increased bone mass. In fact, disruption of only a single allele of OF45 caused significantly increased bone mass. In addition, knockout mice were resistant to aging-associated trabecular bone loss. Cancellous bone histomorphometry revealed that the increased bone mass was the result of increased osteoblast number and osteoblast activity with unaltered osteoclast number and osteoclast surface in knockout animals. Consistent with the bone histomorphometric results, we also determined that OF45 knockout osteoblasts produced significantly more mineralized nodules in ex vivo cell cultures than did wild type osteoblasts. Osteoclastogenesis and bone resorption in ex vivo cultures was unaffected by OF45 mutation. We conclude that OF45 plays an inhibitory role in bone formation in mouse.
Neural network based segmentation using a priori image models (2002)

We examine image segmentation using a Hopfield neural network. Image segmentation is posed as an optimization problem, and is correlated with the energy function of the neural network. By carefully designing the optimization criterion for segmentation, it is possible to identify the bias inputs and the interconnection weights of the corresponding neural network. We provide a general framework for the design of the optimization criterion, which consists of a component based on the observed image, and another component based on an a priori image model. As an application, we consider a smoothness constraint for the segmented image as our a priori information, and solve a gray-level based segmentation problem. The feasibility of using the neural network architecture based on this optimization criterion for the segmentation of masses in mammograms is demonstrated.
Laboratory Experiments on the Failure of Coarse Homogeneous Sediment Natural Dams on a Sloping Bed (2010)

We present the results of a systematic series of 168 laboratory experiments that examine the critical conditions for the failure of landslide dams, which obstruct the course of mountain rivers. The experiments were carried out by using three different sediment materials with a quasiuniform grain size distribution and with a flume bed slope angles that ranged between 0° and 5.71° (0–10%). Three main typologies of dam failure were observed for increasing values of the dam’s downstream-face angle: (1) overtopping; (2) headcutting, which led to the formation of an erosion channel on the dam’s downstream face that progressively migrated up to the dam crest; and (3) initial slide of large part of superficial layer of the dam’s downstream face, which was followed by headcutting. The experiments focused on the second type of failure to provide a safety criterion based on the upstream reservoir level. The quantities that govern this phenomenon have been identified and a functional relationship is proposed based on the dimensional analysis and curve fitting of the minimum level of the upstream reservoir leading to dam failure. A comparison of both the experimental findings and field data that are available in literature shows that the proposed relationship generally provides a conservative estimate for landslide dams in which comminution effects (due to fragmentation of material in the landslide process) are negligible (dam volume lower than 106 m3 ). Finally, the applicability to larger volume landslide dams or to geometric configurations other than those investigated is discussed.
Synthesis and Characterization of Li(Co0.5Ni0.5)PO4 Cathode for Li-Ion Aqueous Battery Applications (2011)

Olivine-type lithium orthophosphate Li(Co0.5Ni0.5)PO4 was synthesized in a solid state reaction at 800 degrees C in air. Infra-red spectroscopy, x-ray and neutron powder diffraction were used to characterize the as-prepared compound and its electro-oxidized analogue. Rietveld analysis was used to illustrate that the synthesized compound is isostructural with LiNiPO4 and LiCoPO4 with lattice parameters larger than the former and smaller than the latter. The Rietveld-refined Ni:Co ratio was found to be 0.498(4):0.502(4) and no evidence for long-range Ni: Co ordering or mixed Li/Ni/Co cation sites was found. The electro-oxidised electrode showed a mixture of two phases i.e. parent Li(Co0.5Ni0.5)PO4 and lithium extracted Li1-x(Co0.5Ni0.5)PO4 suggesting a delithiation process in aqueous electrolytes. Reversible Li transfer between a Li(Co0.5Ni0.5)PO4 electrode and an aqueous LiOH electrolyte was demonstrated. (C) 2011 The Electrochemical Society. [DOI:10.1149/1.3561764] All rights reserved.
Fetal reduction: a neonatologist's point of view (2003)

(2003). Fetal reduction: a neonatologist's point of view. The Journal of Maternal-Fetal & Neonatal Medicine: Vol. 13, No. 5, pp. 289-291.
Elucidating the role of antibiotics on PAL release from E.coli (2020)

Sepsis can result from a systemic bacterial infection, followed by an over‐exuberant immune response, which leads to widespread inflammation. Severe sepsis can result in organ failure and in severe cases, death. Past studies have proposed a role for bacterial Peptidoglycan‐Associated Lipoprotein (Pal) in the pathogenesis of Gram‐negative bacterial sepsis. In this study, we confirmed that Pal is released from Gram‐negative bacteria, Escherichia coli (E. coli), under certain culture conditions, including in the presence of certain antibiotics. Our preliminary results suggest that different antibiotics have differential effects on Pal’s release from E.coli. Since the majority of sepsis patients are administered antibiotics, our findings may be of great significance to the medical field and the sepsis research community. Support or Funding Information RIT FEAD/DRIG and NIH Bootcamp , RIT LSAMP program, Dr. Michael Pichichero Rochester General Hospital Research Institute
Turn it up!: High-load Contact Stabilization (HiCS) is a valuable activated sludge process for maximizing sludge production from sewage (2014)

The conventional approach of wastewater treatment is to maximize effluent quality and minimize operation costs, but this limits the amount of energy that could potentially be recovered.In order to proceed to an energetically self-sustaining wastewater treatment, engineers have taken renewed interest in pre-treatment processes that divert the organics present in the water into well-digestible sludge.In this study, we hypothesize that a High-load Contact Stabilization (HiCS) process is suitable for pre-treating domestic sewage to maximize sludge production.We compared the performance of HiCS to an established high-load process, the so-called A-stage of the 'Adsorptions-Belebungsverfahren'.The HiCS reactor obtained an average removal efficiency of 3410% total COD and 665% dissolved COD.The A-stage performed similarly, with a removal of 3517% total and 773% dissolved COD.In both systems, specific oxygen utilization rates rose and dropped back to near baseline levels within 30 min.aerobic contact time, suggesting that aerobic substrate removal occurs primarily in the early stages of the contact period.Sorption experiments with HiCS sludge showed a fast removal of soluble and particulate substrate within the first min.of contact time.Conversely, sorption experiments with A-stage sludge showed a more gradual and variable pattern of substrate removal.These results indicate that the HiCS sludge is better adapted to quickly remove substrates via sorption than A-stage sludge and may therefore be more suitable for further optimization of sludge production for a maximal recovery of energy.
Emphysema quantification in a multi-scanner HRCT cohort using local intensity distributions (2012)

This article investigates the suitability of local intensity distributions to analyze six emphysema classes in 342 CT scans obtained from 16 sites hosting scanners by 3 vendors and a total of 9 specific models in subjects with Chronic Obstructive Pulmonary Disease (COPD). We propose using kernel density estimation to deal with the inherent sparsity of local intensity histograms obtained from scarcely populated regions of interest. We validate our approach by leave-one-subject-out classification experiments and full-lung analyses. We compare our results with recently published LBP texture-based methodology. We demonstrate the efficacy of using intensity information alone in multi-scanner cohorts, which is a simpler, more intuitive approach.
Population-Based Incremental Interactive Concept Learning for Image Retrieval by Stochastic String Segmentations (2004)

We propose a method for concept-based medical image retrieval that is a superset of existing semantic-based image retrieval methods. We conceive of a concept as an incremental and interactive formalization of the user's conception of an object in an image. The premise is that such a concept is closely related to a user's specific preferences and subjectivity and, thus, allows to deal with the complexity and content-dependency of medical image content. We describe an object in terms of multiple continuous boundary features and represent an object concept by the stochastic characteristics of an object population. A population-based incrementally learning technique, in combination with relevance feedback, is then used for concept customization. The user determines the speed and direction of concept customization using a single parameter that defines the degree of exploration and exploitation of the search space. Images are retrieved from a database in a limited number of steps based upon the customized concept. To demonstrate our method we have performed concept-based image retrieval on a database of 292 digitized X-ray images of cervical vertebrae with a variety of abnormalities. The results show that our method produces precise and accurate results when doing a direct search. In an open-ended search our method efficiently and effectively explores the search space.
Serum bile acids as marker for acute decompensation and acute‐on‐chronic liver failure in patients with non‐cholestatic cirrhosis (2016)

Serum total and individual BAs are associated with AD and ACLF in patients with cirrhosis. Assessment of total BAs could serve as additional marker for risk stratification in cirrhotic patients with respect to new onset of AD and ACLF.
Marker assisted introgression of bacterial blight resistant gene into submergence tolerance rice variety BRRI dhan52 (2017)

BRRI dhan52 is a uniquire submergence tolerant rice variety containing prominant genetic background of BR11, a mega rainfed lowland rice (RLR) variety of Bangladesh, but is susceptible to bacterial blight (BB) caused by Xanthomonas oryzae pv. oryzae (Xoo). The variety is considerably popular in the southern part of Bangladesh due to its high yield in flash flood condition and comparatvely medium slender grain. Molecular markers linked to BB resistance genes (Xa genes) and submergence QTL (SUB1) were utilized in a marker-aided selection program to develop elite breeding lines with broad-spectrum resistance to bacterial blight. Sequence tagged site (STS) and simple sequence repeat (SSR) markers were essentially used to detect the genes for BB and submergence as well. In backcross generation, markers closely linked to Xa21 and SUB1 QTL were used to select desirable plants possessing these resistance genes (foreground selection) and microsatellite markers polymorphic between donor and recurrent parent were also used to select plants that have maximum contribution from the recurrent parent genome (background selection). In BC1F1 generation, three best plants consiquently were selected from previously selected ten double heterozygous (Xa21 and SUB1 QTL) plants. The percentage of recipient genome recovery in the best plant 1, 2 and 3 were 78.7%, 75.83% and 75.4%, respectively. Eventually this work illustrates the successful application of marker-assisted breeding for introgression of bacterial blight resistant gene into a rice variety of Bangladesh.Bangladesh J. Agril. Res. 42(3): 403-411, September 2017
Central Administration of Leptin to Ovariectomized Ewes Inhibits Food Intake without Affecting the Secretion of Hormones from the Pituitary Gland: Evidence for a Dissociation of Effects on Appetite and Neuroendocrine Function* (1999)

Abstract We have studied the effect of leptin on food intake and neuroendocrine function in ovariectomized ewes. Groups (n = 5) received intracerebroventricular infusions of either vehicle or leptin (20μ g/h) for 3 days and were blood sampled over 6 h on days −1, 2, and for 3 h on day 3 relative to the onset of the infusion. The animals were then killed to measure hypothalamic neuropeptide Y expression by in situ hybridization. Plasma samples were assayed for metabolic parameters and pituitary hormones. Food intake was reduced by leptin, but did not change in controls. Leptin treatment elevated plasma lactate and nonesterified fatty acids, but did not affect glucose or insulin levels, indicating a state of negative energy balance that was met by the mobilization of body stores. Pulse analysis showed that the secretion of LH and GH was not affected by leptin treatment, nor were the mean plasma concentrations of FSH, PRL, or cortisol. Expression of messenger RNA for neuropeptide Y in the arcuate nucleus was reduced by the infusion of leptin, primarily due to reduced expression per cell rather than a reduction in the number of cells observed. Thus, the action of leptin to inhibit food intake is dissociated from neuroendocrine function. These results suggest that the metabolic effects of leptin are mediated via neuronal systems that possess leptin receptors rather than via endocrine effects.
SocIoTal — The development and architecture of a social IoT framework (2017)

This paper presents the development and architecture of the SocIoTal platform. SocIoTal is a European FP7 project which aims to create a socially-aware citizen-centric Internet of Things infrastructure. The aim of the project is to put trust, user-control and transparency at the heart of the system in order to gain the confidence of everyday users and developers. By providing adequate tools and mechanisms that simplify complexity and lower the barriers of entry, it will encourage citizen participation in the Internet of Things. This adds a novel and rich dimension to the emerging IoT ecosystem, providing a wealth of opportunities for the creation of new services and applications. These services and applications will be able to address the needs of society therefore improving the quality of life in cities and communities. In addition to technological innovation, the SocIoTal project sought to innovate the way in which users and developers interact and shape the direction of the project. The project worked on new formats in obtaining data, information and knowledge. The first step consisted of gaining input, feedback and information on IoT as a reality in business. This led to a validated iterative methodology which formed part of the SocIoTal toolkit and a best practices guide for local policy makers and cities.
Inducing a Transient Increase in Blood–Brain Barrier Permeability for Improved Liposomal Drug Therapy of Glioblastoma Multiforme (2018)

The blood-brain barrier (BBB) selectively controls the passage of endogenous and exogenous molecules between systemic circulation and the brain parenchyma. Nanocarrier-based drugs such as liposomes and nanoparticles are an attractive prospect for cancer therapy since they can carry a drug payload and be modified to improve targeting and retention at the desired site. However, the BBB prevents most therapeutic drugs from entering the brain, including physically restricting the passage of liposomes and nanoparticles. In this paper, we show that a low dose of systemically injected recombinant human vascular endothelial growth factor induces a short period of increased BBB permeability. We have shown increased delivery of a range of nanomedicines to the brain including contrast agents for imaging, varying sizes of nanoparticles, small molecule chemotherapeutics, tracer dyes, and liposomal chemotherapeutics. However, this effect was not uniform across all brain regions, and permeability varied depending on the drug or molecule measured. We have found that this window of BBB permeability effect is transient, with normal BBB integrity restored within 4 h. This strategy, combined with liposomal doxorubicin, was able to significantly extend survival in a mouse model of human glioblastoma. We have found no evidence of systemic toxicity, and the technique was replicated in pigs, demonstrating that this technique could be scaled up and potentially be translated to the clinic, thus allowing the use of nanocarrier-based therapies for brain disorders.
Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I (2016)

Kinetochores are protein complexes on the chromosomes, whose function as linkers between spindle microtubules and chromosomes is crucial for proper cell division. The mechanisms that facilitate kinetochore capture by microtubules are still unclear. In the present study, we combine experiments and theory to explore the mechanisms of kinetochore capture at the onset of meiosis I in fission yeast. We show that kinetochores on homologous chromosomes move together, microtubules are dynamic and pivot around the spindle pole, and the average capture time is 3-4 minutes. Our theory describes paired kinetochores on homologous chromosomes as a single object, as well as angular movement of microtubules and their dynamics. For the experimentally measured parameters, the model reproduces the measured capture kinetics and shows that the paired configuration of kinetochores accelerates capture, whereas microtubule pivoting and dynamics have a smaller contribution. Kinetochore pairing may be a general feature that increases capture efficiency in meiotic cells.
Affirming inclusive communities: supporting identification as 'locals' by former refugees in regional nsw (2018)

This article is a practice example exploring the scope and impact of ‘I’m a Local…’, an initiative developed in partnership between a regional Australian university, a resettlement community organisation, local organisations and businesses, and members of local refugee communities. The initiative included the development of resources which explored the process of former refugees in developing a sense of belonging and becoming ‘locals’, and sought to improve understandings about refugees, acknowledge their contributions to Australian society and affirm inclusivity in the local culture. This case study provides a positive example of an initiative which had significant local impact in affirming the self-recognition of belonging by former refugees, as well as raising awareness in the broader community about the stories and contributions of people from refugee backgrounds.
The Effects of Subcrestal Implant Placement on Crestal Bone Levels and Bone-to-Abutment Contact: A Microcomputed Tomographic and Histologic Study in Dogs (2015)

Implants with a centralized implant-abutment interface and Morse taper connection can be placed subcrestally without significant loss of crestal or marginal bone. Subcrestal placement of this implant system appears to be advantageous in maintaining bone height coronal to the implant platform.
Nickel‐Catalyzed Cross‐Couplings of Unactivated Alkyl Halides and Pseudohalides with Organometallic Compounds (2004)

Abstract Until recently, there had been a widespread perception that unactivated, β‐hydrogen‐containing alkyl halides/pseudohalides are not suitable partners for nickel‐catalyzed coupling reactions. During the past several years, a number of reports have dispelled this misconception by demonstrating that a diverse array of electrophiles and organometallic reagents can in fact be efficiently cross‐coupled.
A development of Fractal PIFA (planar inverted F antenna) with bandwidth enhancement for mobile phone applications (2009)

A novel fractal planar inverted F antenna (F-PIFA) based on the self affinity design is presented in this paper. The procedure for designing a Fractal Planar Inverted F Antenna is explained and the 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> iteration of Sierpinski Carpet is chosen to use in mobile phones. The F-PIFA has a total dimension 27 mm × 27 mm are designed and optimized in order to receive GSM (global system for mobile communication) and UMTS (universal mobile telecommunication system) and HiperLAN (high performance radio LAN with the frequency range from 1710 MHz to 2170 MHz, 1885 to 2200 MHz for 3 G and 4800 MHz to 5800 MHz for HiperLAN respectively. The antenna achieved the GSM, UMTS and HiperLan frequency with -6 dB return loss and has almost omnidirectional radiation pattern. This antenna has been tested using mobile phone model and all the performance met the criteria for a mobile phone application.
Figure S4 from A Potent Blood–Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model (2023)

&lt;p&gt;DS-1001b permeates the blood-brain barrier and inhibits tumor growth in an orthotopic PDX model.&lt;/p&gt;