gebhart/patrepeval huggingface dataset:
Data-independent acquisition mass spectrometry quantitative proteomic analysis reveals that skin aging-related proteins differ between men and women (2021)

The skin is the largest organ of the human body, and its aging is visible to the naked eye. The aging rate of men and women is slightly different. This study compared the protein expression of skin samples on the curved forearms of 11 healthy women and 9 healthy men. Quantitative proteomics analysis found that the expression of epidermal proteins in men and women of the same age group was different. Compared with female skin, in male skin, 20 proteins were upregulated, and 7 proteins were downregulated. These data suggest that men and women have differences in the speed of skin aging. For the first time in this experiment, a non-invasive mass spectrometer was used to detect 27 different-related epidermal proteins between men and women. Compared with women, among the 20 epidermal proteins upregulated in men, their functions can be classified into antioxidants, epidermal lipid metabolism, signal transduction, membrane transport, and cell biological processes; the 7 downregulated proteins are involved in a variety of biological processes and inflammatory reactions. Our experiments have discovered epidermal proteins related to the differences between men and women, enriching the library of epidermal differential proteins between men and women and enriching the mechanism of skin aging between men and women from the perspective of epidermal differential proteins.
Multi-Regional Adaptation in Human Auditory Association Cortex (2017)

In auditory cortex, neural responses decrease with stimulus repetition, known as adaptation. Adaptation is thought to facilitate detection of novel sounds and improve perception in noisy environments. Although it is well established that adaptation occurs in primary auditory cortex, it is not known whether adaptation also occurs in higher auditory areas involved in processing complex sounds, such as speech. Resolving this issue is important for understanding the neural bases of adaptation and to avoid potential post-operative deficits after temporal lobe surgery for treatment of focal epilepsy. Intracranial electrocorticographic recordings were acquired simultaneously from electrodes implanted in primary and association auditory areas of the right (non-dominant) temporal lobe in a patient with complex partial seizures originating from the inferior parietal lobe. Simple and complex sounds were presented in a passive oddball paradigm. We measured changes in single-trial high-gamma power (70-150 Hz) and in regional and inter-regional network-level activity indexed by cross-frequency coupling. Repetitive tones elicited the greatest adaptation and corresponding increases in cross-frequency coupling in primary auditory cortex. Conversely, auditory association cortex showed stronger adaptation for complex sounds, including speech. This first report of multi-regional adaptation in human auditory cortex highlights the role of the non-dominant temporal lobe in suppressing neural responses to repetitive background sounds (noise). These results underscore the clinical utility of functional mapping to avoid potential post-operative deficits including increased listening difficulties in noisy, real-world environments.
Percutaneous endoscopic jejunostomy in patients with gastroparesis following lung transplantation: feasibility and clinical outcome (2012)

The aim of the present study was to describe success rates, complications, and outcome in patients who underwent percutaneous endoscopic jejunostomy (PEJ) because of gastroparesis due to previous lung transplantation. Between October 2008 and May 2011, 14 attempts at PEJ placement were made in 12 patients in our center. Of the 14 attempts, 11 were successful, giving a technical success rate of 78.6 %. Median duration of follow-up was 8.5 months (2 – 15 months). No immediate complications were reported. Two severe complications occurred during follow up (one volvulus and one jejunocolic fistula). Jejunal nutrition was well tolerated in most of patients (9 /10). PEJ insertion is a feasible technique, which could help to provide nutritional support for patients with gastroparesis and previous lung transplantation.
Joint estimation of calibration and expression for high-density oligonucleotide arrays (2006)

R functions are available on request from the authors.
Phase formation in Cr-Si thin-film interactions (1980)

Silicide formation has been studied in Cr-Si thin-film samples by MeV 4He+ backscattering and glancing-incidence x-ray diffraction. Samples of SiO2/Cr/Si configuration were prepared by sequential e-gun deposition of Cr and Si onto SiO2 substrates with the relative film thicknesses adjusted to Cr:Si ratios of 3.0 (Cr3Si), 1.67 (Cr5Si3), and 1.0 (CrSi). In the early stage of phase formation when both unreacted Cr and Si are present, the CrSi2 phase is formed. The phase grows until the Si is completely consumed, and then a metal-rich phase, Cr5Si3, is formed at the Cr-CrSi2 interface. Upon further heating of samples with a Cr:Si ratio of 3.0, Cr5Si3 reacts with Cr to form a more Cr-rich phase, Cr3Si. The CrSi phase was observed only in samples with a Cr:Si ratio of 1. All the compounds present in the phase diagram were observed. The end phases are determined by the availability of Cr and Si in the reactions and can be predicted from the phase diagram.
Sentence-level MT evaluation without reference translations: Beyond language modeling (2005)

Abstract. In this paper we investigate the possibility of evaluating MT quality and fluency at the sentence level in the absence of reference translations. We measure the correlation between automatically-generated scores and human judgments, and we evaluate the performance of our system when used as a classifier for identifying highly dysfluent and illformed sentences. We show that we can substantially improve on the correlation between language model perplexity scores and human judgment by combining these perplexity scores with class probabilities from a machine-learned classifier. The classifier uses linguistic features and has been trained to distinguish human translations from machine translations. We show that this approach also performs well in identifying dysfluent sentences. 1.
Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus (2017)

We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor Dome or the Janus kinase Hop by the blood feeding-induced vitellogenin (Vg) promoter. Transgene expression inhibits infection with several dengue virus (DENV) serotypes in the midgut as well as systemically and in the salivary glands. The impact of the transgenes Dome and Hop on mosquito longevity was minimal, but it resulted in a compromised fecundity when compared to wild-type mosquitoes. Overexpression of Dome and Hop resulted in profound transcriptome regulation in the fat body tissue as well as the midgut tissue, pinpointing several expression signatures that reflect mechanisms of DENV restriction. Our transcriptome studies and reverse genetic analyses suggested that enrichment of DENV restriction factor and depletion of DENV host factor transcripts likely accounts for the DENV inhibition, and they allowed us to identify novel factors that modulate infection. Interestingly, the fat body-specific activation of the JAK/STAT pathway did not result in any enhanced resistance to Zika virus (ZIKV) or chikungunya virus (CHIKV) infection, thereby indicating a possible specialization of the pathway's antiviral role.
Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma (2019)

ctDNA-NGS characterized GEA molecular heterogeneity and rendered important prognostic and predictive information, complementary to tissue-NGS.<i>See related commentary by Frankell and Smyth, p. 6893</i>.
Chemotherapy-induced diarrhoea (2009)

Here, we describe the current thinking behind the mechanisms of chemotherapy-induced diarrhoea and present current and new treatment options. This opinion article highlights the shift towards more effective research into diarrhoea caused by chemotherapy.
Induction motors Diagnosis using Deceleration Test, a possible Improvement (2003)

Non-invasive diagnosis of incipient or actual faults ofgrid supplied induction machine is a well known technology.Motor Current Signature Analysis (MCSA) can be used forrotor and stator defects. These include stator current harmonicsat frequencies (1± 2s) f and also determining the negativesequence component of current space vector. Recently,deceleration tests which possibly can remove several drawbacksof MCSA have been proposed for rotor and stator faultdiagnosis.This paper attempts to compare the MCSA-based diagnosticprocedures with the results obtained using the deceleration tests.Experimental results show that although the deceleration testdoes not provide clear information on rotor defects, it provides adiagnostic index directly related to the percentage of shortedturns. This diagnostic index can be used to validate the MCSAbased diagnostic procedure.
THREE MONTH SURVIVAL OF CALVES IMPLANTED WITH COMPLETE DEBAKEY VAD™ SYSTEM (1999)

Morley, D; Benkowski, R; Fossum, T; Olsen, D; Burns, G; Lynch, B; Vinnerqvist, A; Franks, J; Noon, G; DeBakey, M E
Mechanism of the Prorelaxing Effect of Thyroxine on the Sphincter of Oddi (2002)

We conclude that T4 has a direct prorelaxing effect on human SO that expresses TR beta1 and beta2. This effect is mediated through a transcriptional mechanism that requires new mRNA and protein synthesis and subsequently leads to the activation of K+ channels.
Heterogeneous Constellation Design for a Smart Soil Moisture Radar Mission (2021)

This article explores the tradespace for a constellation of heterogeneous smart satellites intended to measure soil moisture using a combination of L and P band radars, radiometers, and reflectometers. Orbit inclination, repeat cycle, number of satellites, and number of planes were treated as input variables to create a set of architectures for evaluation. Attempting to optimize multiple output variables (cost, average revisit time, maximum revisit time, and percent coverage) results in a complex tradespace with suitable options at various cost caps. Therefore, several cost ranges are examined to find the best constellation for a given cost cap. It was found that a relatively simple constellation of three satellites in one plane offers acceptable performance at a low cost. This preliminary submission shows results for a homogeneous constellation, while the final paper will include satellites with various instrument configurations.
High resolution epitope mapping of an anti-DNA autoantibody using model DNA ligands. (1994)

Although Ab-DNA complexes are involved in the pathogenesis of SLE, the mechanism by which anti-DNA recognize their DNA targets remains elusive. We have designed and synthesized small test DNA ligands that model ssDNA and dsDNA determinants commonly recognized by anti-DNA autoantibodies. These ligands were used in DNA footprinting assays to conduct a high resolution epitope-mapping study of anti-ssDNA BV04-01, which is typical of anti-ssDNA expressed in (NZB x NZW)F1 mice. We find that BV04-01 recognizes the ssDNA, but not dsDNA, epitopes presented on the test ligands, and makes specific base and backbone contacts with the DNA. Moreover, BV04-01 binding induces conformational changes in both the single-stranded and duplex region of the ligands. The epitope-mapping data is used in conjunction with computational molecular modeling to construct a three-dimensional model of a BV04-01-ligand complex. The salient aspects of this model are consistent with many features observed in the crystal structure of BV04-01 liganded to d(pT)3. This work extends previous anti-DNA binding studies and attempts to provide a unified approach that draws upon the merits of many precedented experimental methods to assemble three-dimensional structures of anti-DNA-DNA complexes. Analysis of these structures may ultimately help guide the development of molecules designed to inhibit anti-DNA binding in SLE.
Laser-induced photodetachment in a magnetically confined low-pressure argon-acetylene plasma destined for nanoparticles formation (2015)

International audience
Effects of osmotic priming on dormancy and storability of tomato (Lycopersicon esculentumMill.) seeds (1996)

Abstract Freshly harvested tomato ( Lycopersicon esculentum Mill, cv. Moneymaker) seeds were osmotically primed for 8 d in −1.0 MPa PEG-6000 solution and dried to about 6% water content for storage. Such so–called ‘fresh PEG priming’ enhanced seed germination and improved seedling performance as compared with the untreated control. Fresh PEG priming neither alleviated seed dormancy nor promoted DNA replication as was the case when seeds were dried upon harvest and subsequently primed in PEG (normal PEG priming). However, the addition of 10 μM GA 4+7 to the osmotic priming solution triggered replicative DNA synthesis of fresh-priming seeds and further enhanced the germination process. After 5 months of storage in ambient temperature conditions, fresh PEG-primed seeds maintained more positive effects gained from priming, whereas, normal PEG-primed seeds had lost the promoting effects on germination. Normal PEG-primed seeds were much more susceptible to controlled deterioration than fresh PEG-primed seeds. It is suggested that the advancement of germination is negatively correlated with seed storability. The mechanisms of seed priming in relation to nuclear replication activities and physical changes are discussed.
Optimum central processors for spectral-shape discrimination (1985)

The sensitivities of optimum central processors for discriminating spectral-shape differences in fixed- and roving-level paradigms are derived. The processors are assumed to operate on the logarithms of band levels derived from internal filters, with each log-band level corrupted by independent Gaussian noise. When the receiver is unable to use a priori knowledge of the roving-level distribution, the sensitivity of a receiver which estimates overall level is the same as that which makes decisions based on level differences between adjacent bands. When a priori Knowledge of the roving-level distribution is available, sensitivity is increased provided the roving level is narrow compared to the aggregate band-level variance. These results are extended to the case of compound external degradations in spectral shape, such as random spectral tilt and curvature, and to the case in which adjacent bands are also corrupted by correlated noise. [Work suppported by NIH.]
Estimating note intensities in music recordings (2011)

In this paper, we present automated methods for estimating note intensities in music recordings. Given a MIDI file (representing the score) and an audio recording (representing an interpretation) of a piece of music, our idea is to parametrize the spectrogram of the audio recording by exploiting the MIDI information and then to estimate the note intensities from the resulting model. The model is based on the idea of note-event spectrograms describing the part of a spectrogram that can be attributed to a given note event. After initializing our model with note events provided by the MIDI, we adapt all model parameters such that our model spectrogram approximates the audio spectrogram as accurately as possible. While note-wise intensity estimation is a very challenging task for general music, our experiments indicate promising results on polyphonic piano music.
Vision et révision de la mort volontaire dans la littérature irlandaise contemporaine (1998)

Au début de son épopée homérique, Léopold Bloom assiste à l'inhumation de Paddy Dignam et rejoint Dedalus, Martin Cunningham et M. Power dans la voiture mortuaire. Les personnages déplorent la disparition de leur ami, décédé d'une crise cardiaque, et une conversation s'engage alors sur les différentes façons de mourir : -But the worst of all, Mr Power said, is the man who takes his own life.Martin Cunningham drew out his watch briskly, coughed and put it back.- The greatest disgrace to have i...
Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction (2011)

An interesting clinical option for optimizing healing tissue is the use of platelet concentrate. Platelets contain high quantities of growth factors, among these TGF-β1 and VEGF, which are known to be implicated in tissue regeneration. CGF is produced by processing blood samples with a special centrifuge device; three layers are formed: top acellular plasma (PPP), middle CGF and bottom red blood cells (RBC) layers. Given that to date there are no data concerning the biological characteristic of CGF, the aim of this study was to evaluate the presence of TGF-β1 and VEGF in CGF and also in PPP and RBC layers. In addition, since circulating stem cells are recruited from blood to injured tissue for healing we also evaluated the presence of CD34 positive cells. Our data show the presence of TGF-β1 and VEGF in CGF and RBC layers. In addition, we show CD34 positive cells in CGF.
Data from Epigenetic Silencing of miR-137 Is an Early Event in Colorectal Carcinogenesis (2023)

&lt;div&gt;Abstract&lt;p&gt;Global downregulation of microRNAs (miRNA) is a common feature in colorectal cancer (CRC). Whereas CpG island hypermethylation constitutes a mechanism for miRNA silencing, this field largely remains unexplored. Herein, we describe the epigenetic regulation of miR-137 and its contribution to colorectal carcinogenesis. We determined the methylation status of miR-137 CpG island in a panel of six CRC cell lines and 409 colorectal tissues [21 normal colonic mucosa from healthy individuals (N-N), 160 primary CRC tissues and their corresponding normal mucosa (N-C), and 68 adenomas]. TaqMan reverse transcription-PCR and &lt;i&gt;in situ&lt;/i&gt; hybridization were used to analyze miR-137 expression. &lt;i&gt;In vitro&lt;/i&gt; functional analysis of miR-137 was performed. Gene targets of miR-137 were identified using a combination of bioinformatic and transcriptomic approaches. We experimentally validated the miRNA:mRNA interactions. Methylation of the miR-137 CpG island was a cancer-specific event and was frequently observed in CRC cell lines (100%), adenomas (82.3%), and CRC (81.4%), but not in N-C (14.4%; &lt;i&gt;P&lt;/i&gt; &lt; 0.0001 for CRC) and N-N (4.7%; &lt;i&gt;P&lt;/i&gt; &lt; 0.0001 for CRC). Expression of miR-137 was restricted to the colonocytes in normal mucosa and inversely correlated with the level of methylation. Transfection of miR-137 precursor in CRC cells significantly inhibited cell proliferation. Gene expression profiling after miR-137 transfection discovered novel potential mRNA targets. We validated the interaction between miR-137 and &lt;i&gt;LSD-1&lt;/i&gt;. Our data indicate that miR-137 acts as a tumor suppressor in the colon and is frequently silenced by promoter hypermethylation. Methylation silencing of miR-137 in colorectal adenomas suggests it to be an early event, which has prognostic and therapeutic implications. Cancer Res; 70(16); 6609–18. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
Integrated High-frequency Reference Clock Systems Utilizing Mirror-encapsulated BAW Resonators (2019)

This work introduces an integrated reference clock system using a 2.5 GHz mirror-encapsulated BAW (bulk acoustic wave) resonator as the frequency source. With acoustic mirrors also placed on top of the resonator, this symmetrical DBAR (dual-Bragg acoustic resonator) structure offers extra design freedoms to alter the resonator's acoustic properties. A DBAR requires no cavity on either side of the resonator yet still immune to mass loading effect from contamination and assembly. This advantage enables cost-effective system integration by directly marrying a DBAR and a CMOS die in a plastic package. System chips utilizing DBAR as the high-frequency reference clocks are demonstrated here. With compensation algorithm and careful design of the package, these DBAR-based clocking systems can achieve ±25 ppm stability over the entire operation temperature range (including aging, solder shift, etc.), resulting industry's first crystal-less BLE (Bluetooth Low Energy) radio chip.
Origins of magnetic recording concepts (1985)

Many brand new ideas in modern magnetic recording are quite ancient. Case histories in basic foundations of this art are good examples. Metal particle tape was proposed 95 years ago. High-frequency bias has its roots in the Marconi wireless detector of 1902. Digital recording goes back at least to Morse’s telegraph of 1838. The rotating-head principle used for video recorders dates back about two decades before it became practical. Sendust used in the latest recording heads was invented in 1936. Magnetic disks, the important memory of computers, were demonstrated in 1903. Soundstriping for motion picture film was advertised in 1917. Personal experiences in nearly a half-century of magnetic recording are related.
Computer interfaced fast kinetics luminescence decay experiment (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComputer interfaced fast kinetics luminescence decay experimentR. M. Ballew , J. N. Demas , N. P. Ayala , M. Grubb , and S. W. Snyder Cite this: J. Chem. Educ. 1991, 68, 3, 222Publication Date (Print):March 1, 1991Publication History Received3 August 2009Published online1 March 1991Published inissue 1 March 1991https://doi.org/10.1021/ed068p222RIGHTS & PERMISSIONSArticle Views187Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
Crosstalk between Wnt and bone morphogenic protein signaling: A turbulent relationship (2009)

The Wnt and the bone morphogenic protein (BMP) pathways are evolutionarily conserved and essentially independent signaling mechanisms, which, however, often regulate similar biological processes. Wnt and BMP signaling are functionally integrated in many biological processes, such as embryonic patterning in Drosophila and vertebrates, formation of kidney, limb, teeth and bones, maintenance of stem cells, and cancer progression. Detailed inspection of regulation in these and other tissues reveals that Wnt and BMP signaling are functionally integrated in four fundamentally different ways. The molecular mechanism evolved to mediate this integration can also be summarized in four different ways. However, a fundamental aspect of functional and mechanistic interaction between these pathways relies on tissue-specific mechanisms, which are often not conserved and cannot be extrapolated to other tissues. Integration of the two pathways contributes toward the sophisticated means necessary for creating the complexity of our bodies and the reliable and healthy function of its tissues and organs.