gebhart/patrepeval huggingface dataset:
Salmonella isolation with Rappaport's enrichment medium of different compositions. (1981)

One hundred samples of feces of normal pigs were examined for the presence of salmonellae. The feces were pre-enriched for 18 h in peptone water and then, 0.1 ml of the pre-enrichment medium was inoculated in 10 ml of the original Rappaport medium (R30), and two modifications (R25 and R10) of this medium. Two of the broths (R30 and R25) were incubated at 37 degrees C (R30/37 degrees C and R25/37 degrees C) while the R10 medium was incubated at 43 degrees C (R10/43 degrees C). In addition 100 ml of R10 medium (R10/100 ml/43 degrees C) and 100 ml of the standardized Muller Kauffmann's tetrathionate broth (MK/100 ml/43 degrees C) (Edel and Kampelmacher, 1969) were inoculated with 1 ml and 10 ml, respectively, of the pre-enrichment medium, and incubated at 43 degrees C. With the method R10/100 ml/43 degrees C, 37 samples were found positive while with the method MK/100 ml/43 degrees C only 22 positive samples were detected (P less than 0.001). With the Rappaport media in 10 ml volumes, the modification R10 yielded 26 positive samples, while the R30 and R25 broths yielded only 15 and 19 positive samples. All Rappaport procedures had a much stronger inhibition of the competing organisms, particularly those giving Salmonella-like colonies (lactose and sucrose negative), than the MK/100 ml/43 degrees C method, a fact of considerable importance in everyday's practice.
High Voltage Tolerant Linear Regulator With Fast Digital Control for Biasing of Integrated DC-DC Converters (2007)

Integrated DC-DC converters switching above 100MHz dramatically reduce the footprint of the inductors and capacitors while improving droop response. Unfortunately, such converters utilize advanced digital CMOS processes with the maximum input voltage below 2 V. We propose a fully integrated linear regulator that enables doubling of the converter input voltage by properly biasing stacked drivers and bridge transistors. By implementing fast digital control the linear regulator meets the transient current demand of the converter without resorting to off-chip decoupling capacitors. In a 90 nm CMOS process, the 2.4V input, 1.2 V output, linear regulator occupies 0.03 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a plusmn1 A rating. A 288 ps response time and 97.5% current efficiency result in a 2.84times improvement in speed-power figure of merit over previous work
Computation in generalised probabilisitic theories (2015)

From the general difficulty of simulating quantum systems using classical systems, and in particular the existence of an efficient quantum algorithm for factoring, it is likely that quantum computation is intrinsically more powerful than classical computation. At present, the best upper bound known for the power of quantum computation is that ${\\bf{BQP}}\\subseteq {\\bf{AWPP}}$, where ${\\bf{AWPP}}$ is a classical complexity class (known to be included in ${\\bf{PP}}$, hence ${\\bf{PSPACE}}$). This work investigates limits on computational power that are imposed by simple physical, or information theoretic, principles. To this end, we define a circuit-based model of computation in a class of operationally-defined theories more general than quantum theory, and ask: what is the minimal set of physical assumptions under which the above inclusions still hold? We show that given only an assumption of tomographic locality (roughly, that multipartite states and transformations can be characterized by local measurements), efficient computations are contained in ${\\bf{AWPP}}$. This inclusion still holds even without assuming a basic notion of causality (where the notion is, roughly, that probabilities for outcomes cannot depend on future measurement choices). Following Aaronson, we extend the computational model by allowing post-selection on measurement outcomes. Aaronson showed that the corresponding quantum complexity class, ${\\bf{PostBQP}}$, is equal to ${\\bf{PP}}$. Given only the assumption of tomographic locality, the inclusion in ${\\bf{PP}}$ still holds for post-selected computation in general theories. Hence in a world with post-selection, quantum theory is optimal for computation in the space of all operational theories. We then consider whether one can obtain relativized complexity results for general theories. It is not obvious how to define a sensible notion of a computational oracle in the general framework that reduces to the standard notion in the quantum case. Nevertheless, it is possible to define computation relative to a 'classical oracle'. Then, we show there exists a classical oracle relative to which efficient computation in any theory satisfying the causality assumption does not include ${\\bf{NP}}$.
The Relationship Between Satisfaction With On-The-Job Training And Overall Job Satisfaction (2004)

This study examined the relationship between satisfaction with employer-provided workplace&#13;\ntraining and overall job satisfaction. Survey completion data were obtained from 301 customer&#13;\nand technical service employees in nine different organizations. Job duties for employees in&#13;\nthese positions are employer specific. As such, these employees rely on their employers for&#13;\ninitial and ongoing job training. Organizations represented included those in manufacturing,&#13;\ntechnology, service, and government. A significant relationship was found between job training satisfaction and overall job satisfaction. Time spent in training, training methodologies, and type of training were determined to be significant in their relationships to job training satisfaction. The&#13;\nmethodology used in training made a significant difference in job training satisfaction. Most&#13;\npreferred by respondents were methodologies that involved face-to-face interaction provided by&#13;\nan instructor or job coach. Also found were significant interactions between job tenure and&#13;\nemployment type (customer service representative or technical service representative) when&#13;\nexamined with job training satisfaction. Based on these findings, recommendations were made&#13;\nfor practitioners in the fields of training and human resource development, as well as for&#13;\nmanagers of employees working in customer and technical service occupations.
Management of hyperlipidemia: goals for the prevention of atherosclerosis. (1990)

The goals of treatment for patients with hyperlipoproteinemia are to reduce plasma concentrations of known atherogenic lipoproteins, thereby exerting a favorable effect upon lipid deposition in the arterial wall and, less commonly, to prevent the adverse sequelae of hyperchylomicronemia in patients with severe hypertriglyceridemia. Diet is the cornerstone of the therapy after the exclusion of secondary factors; the decision to begin drug therapy should be made only after an adequate trial of diet has failed to achieve satisfactory concentrations of plasma lipids and lipoproteins. For patients without evidence of atherosclerosis the goals is to reduce the plasma concentrations of low density lipoproteins to below 160 mg/dl (4.2 mM/L); for those individuals with atherosclerosis or the concurrent presence of two risk factors, a lower level of LDL is desirable (less than 130 mg/dl; 3.4 mM/L). For regression to occur the LDL level may need to be below 100 mg/dl (2.6 mM/L). The bile acid sequestrants (cholestyramine and colestipol), nicotinic acid, fenofibrate, and inhibitors of HMG CoA reductase (e.g., lovastatin or simvastatin) are the most effective drugs for use in patients with primary hypercholesterolemia and these agents reduce plasma concentrations of total and LDL cholesterol by 15-45%. For those patients with concurrent hypertriglyceridemia, nicotinic acid, lovastatin or simvastatin, or fenofibrate are the preferred drugs for initial use. Fibric acid derivatives (e.g., clofibrate, gemfibrozil, bezafibrate, or fenofibrate) are all effective in the therapy of patients with type III hyperlipoproteinemia, as is nicotinic acid or lovastatin.(ABSTRACT TRUNCATED AT 250 WORDS)
Vertical cavity surface emitting microlasers (2002)

Summary form only given. Recent progress in semiconductor microlaser device performance and design, integration with electronic circuitry and micro-optics, and the applicability of microlaser arrays to optical interconnects, signal processing and displays will be presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Reactions of Diaziridines with Benzynes Give N-Arylhydrazones (2018)

Reactions of thermally generated benzynes with diaziridines are reported. These trapping reactions follow the same pathway as reported earlier by Heine and co-workers with electron-deficient alkynes. The resulting N-arylhydrazones were obtained efficiently in a single step. The preference for the mode of addition of the nucleophilic diaziridine nitrogen atom to the more electrophilic benzyne carbon was consistent with what is predicted on the basis of distortion analysis. The feasibility of converting the hydrazone into a Fisher-indole adduct was demonstrated.
The effect of medium composition on the production of sophorolipids and the tensiometric properties by Starmerella bombicola MTCC 1910 (2010)

The effect of medium composition on the production of sophorolipids and the tensiometric properties by Starmerella bombicola MTCC 1910 Starmerella bombicola a teleomorph of Candida bombicola is capable of producing extracellular secondary metabolites known as sophorolipids. In the present work the performance of Starmerella in producing sophorolipids, with standard medium ingredients glucose, sunflower oil, yeast extract and urea was studied. The quantities of different medium ingredients were optimized to maximize the production of sophorolipids. Variation in tensiometric properties like surface tension and interfacial tension during the incubation period were also reported. The optimized mixed substrate composition was found to be 200 g/l, containing equal amounts of glucose and sunflower oil, 4 g/l of yeast extract and 0.6 g/l of urea. With the optimized substrate composition 38.6 g/l of sophorolipids was obtained. The minimum surface tension produced by the culture free cell broth was 36.2 mN/m. Increasing the temperature from 25°C to 35°C has shown adverse effects on sophorolipids production.
Characteristics of Renin Subgroups of Patients with Essential Hypertension. (1973)

Meeting Abstracts1 May 1973Characteristics of Renin Subgroups of Patients with Essential Hypertension.Hans R. Brunner, M.D., Jean E. Sealey, B.Sc., John H. Laragh, M.D., F.A.C.P.Hans R. Brunner, M.D.Search for more papers by this author, Jean E. Sealey, B.Sc.Search for more papers by this author, John H. Laragh, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-828_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClassification of 219 patients with essential hypertension according to their renin levels has exposed three subgroups with different physiologic and epidemiological characteristics.Twenty-seven percent of the patients had subnormal renin levels, and they have been shown previously to be relatively protected from heart attacks and strokes. These patients with low renin levels had a blunted aldosterone response to sodium deprivation, which was associated with significant potassium retention (P< 0.05) and a rise in plasma bicarbonate (P< 0.05). At all three levels of sodium intake low renin patients had the lowest blood urea nitrogen levels and therefore appeared to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 828-828KeywordsAldosteroneBicarbonatesBlood plasmaBlood urea nitrogenHypertensionMyocardial infarctionPotassiumSodiumStroke Issue Published: 1 May 1973 PDF downloadLoading ...
Insegt Fibre: A Powerful Segmentation Tool for Quantifying Fibre Architecture in Composites (2019)

Insegt Fibre is a tool for volumetric fibre segmentation, that is appropriate for densely packed fibres. The robustness to image quality of the underlying dictionary-based algorithm has opened up new opportunities for micro-structural characterisation of fibre-reinforced polymers. The recent user-friendly version of the robust fibre-detection algorithm makes image-based characterisation of fibrous materials simpler and more accessible.
Xentry: Hypervisor-Level Soft Error Detection (2014)

Cloud data centers leverage virtualization to share commodity hardware resources, where virtual machines (VMs) achieve fault isolation by containing VM failures within the virtualization boundary. However, hypervisor failure induced by soft errors will most likely affect multiple, if not all, VMs on a single physical host. Existing fault detection techniques are not well equipped to handle such hypervisor failures. In this paper, we propose a new soft error detection framework, Xentry (a sentry on soft error for Xen), that focuses on limiting error propagation within and from the hypervisor. In particular, we have designed a VM transition detection technique to identify incorrect control flow before VM execution resumes, and a runtime detection technique to shorten detection latency. This framework requires no hardware modification and has been implemented in the Xen hypervisor. The experiment results show that Xentry incurs very small performance overhead and detects over 99% of the injected faults.
Correction: Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease (1989)

After our characterization of cDNA encoding a 47-kD neutrophil cytosol oxidase factor was published, a second group published characterizations of similar cDNA clones. On the basis of an exchange of primary sequence data and resequencing, we have identified minor errors in both published sequences and have agreed on a corrected sequence. In the original numbering of our published sequence, an extra "C" should be added after base pair 900, a "GCC" should be inserted after base pair 1008, and base pairs 1013 and 1014 should be "GC." These changes alter the carboxyl terminus of the predicted protein beginning at amino acid 301 and ending at 390: RRSSIRNAHS IHQRSRKRLS QDAYRRNSVR FLQQRRRQAR PGPQSPGSPL EEERQTQRSK PQPAVPPRPS ADLILNRCSE STKRKLASAV. The new predicted protein sequence is 17 amino acids longer. The region of similarity to p21-ras- GAP is unaffected, and the carboxyl terminus remains very arginine- and serine-rich with several potential sites of phosphorylation by protein kinase C. Thus, all of the general statements made about the protein in our original paper still apply. In addition to the three polymorphic base pair variants we reported in our original paper, four additional base pair polymorphisms have been identified, none of which affects encoded amino acids. In the original numbering, these are base pair 387 "G" or "A," base pair 825 "C" or "T," base pair 849 "A" or "G," and base pair 935 "C" or "T." These changes have been sent to Gen- Bank and entered under accession number M25665. Readers may also request from us the complete corrected sequence.
Perkutane Implantation von Gefäßendoprothesen (Stents) in Becken- und Oberschenkelarterien (2008)

Flexible, self-expanding metallic mesh stents were implanted via a percutaneous catheter delivery system, immediately after balloon dilatation, in 68 patients (59 males and 9 females; mean age 56.6 [40-73] years). All had stenoses or occlusion of the iliac or femoral arteries. The bridged vessel segments were 3.5-27 cm long; the stent lumen ranged from 6 to 12 mm diameter. Good blood flow was restored in all 68 patients. The Doppler sonographic index increased on average by 0.33 to a mean of 0.9 (0.4-1.2). An early stent occlusion occurred in three patients (one femoral artery with a stented length of 27 cm thrombosed after 24 hours, two iliac stents were found to be occluded four and eight weeks, respectively, after insertion). Transitory peripheral emboli occurred in two patients with femoral stents. In five patients (four with femoral stents, one with an iliac stent) marked intimal hyperplasia with stenosis developed after 4-10 months; in four of them they were successfully treated by the percutaneous technique. The described percutaneous stent placement method is suitable for treating arterial stenoses or occlusions which cannot be satisfactorily dilated by balloon, as well as restenoses and local complications after angioplasty. It is particularly effective in iliac arteries.
Phase 1 trial of TIM-3 inhibitor cobolimab monotherapy and in combination with PD-1 inhibitors nivolumab or dostarlimab (AMBER). (2022)

2504 Background: TIM-3 expressed on tumor-infiltrating T cells is associated with T-cell suppression. AMBER (NCT02817633) is evaluating cobolimab (TSR-022/GSK4069889) monotherapy and with PD-1 inhibitors in advanced solid tumors. Methods: Multi-center, open-label study conducted with the following escalation arm (Parts 1A–C primary analysis reported here): (1A) cobolimab (IV Q2W) monotherapy at 7 doses (6 weight-based [0.03–10 mg/kg] and 1 flat [1200 mg] dose); (1B) cobolimab (1 mg/kg) + nivolumab (3 mg/kg IV Q2W); and (1C) cobolimab (100, 300, or 900 mg) + dostarlimab (500 mg IV Q3W). Primary endpoints were safety, tolerability, and recommended phase 2 dose (RP2D, monotherapy and combination). Results: 104 patients (pts) were included: 1A (n=46), 1B (n=7), or 1C (n=55); 4 pts from 1A crossed over to 1C (included in 1A and 1C safety and efficacy analyses). Most common cancers were non-small cell lung cancer (NSCLC) and melanoma (1A), NSCLC (1B), and NSCLC, skin, and peritoneal mesothelioma (1C). In 1A, 30.4% had ≥5 lines (L) of prior therapy; 42.9% had 3L in 1B; 33.3% had 2L in 1C. Treatment-related treatment-emergent adverse events (TR-TEAE) occurred in 67.4% (1A), 85.7% (1B), and 67.3% (1C); most commonly in 1A (n≥4) fatigue (13.0%) and nausea (8.7%); 1B (n≥3) diarrhea (57.1%) and nausea and vomiting (42.9% each); and 1C (n≥8) fatigue (20.0%) and rash (14.5%). Grade (Gr)≥3 TR-TEAEs occurred in 4.3% (1A), 28.6% (1B), and 14.5% (1C). There were no Gr5 TR-TEAEs or TR-TEAEs leading to dose delay. Serious TR-TEAEs occurred in 2.2% (1A), 0% (1B), and 12.7% (1C). TR-TEAEs led to discontinuation in 2.2% (1A), 28.6% (1B), and 9.0% (1C). Dose limiting toxicities (DLTs) occurred in 3.0% (1/33) in 1A (Gr3 lipase increased [10 mg/kg]); 40.0% (2/5) in 1B (Gr3 diarrhea and ALT and AST elevation); and 0% in 1C. Cobolimab serum exposure increased in a dose proportional manner at the therapeutic dose range. Preliminary mean terminal phase t 1/2 ranged from 2.5–5.8 days for 0.03–0.3 mg/kg and 6.9–10.2 days for 1–10 mg/kg doses (1A), 6.9 days for 1B, and 9.5–12.3 days for 1C. Conclusions: Cobolimab + dostarlimab was well tolerated and showed preliminary anti-tumor activity, warranting further investigation of the RP2D + docetaxel in a randomized, phase 2 study. Funding: GSK (213348). Clinical trial information: NCT02817633. [Table: see text]
N-Metallocenyl Ynamides: Preparation, Oxidative Functionaliza-tion and Synthesis of an ansa[3]-Ferrocenylamide (2022)

The discovery of new organometallic frameworks is of high interest for the field of bioorganometallic chemistry. In this work, to the best of our knowledge, we report the first synthesis of various N-metallocenyl ynamides and some of their reactivity. In particular, the use of hypervalent iodine(III) reagents triggered an unprecedented oxidative cyclization leading to ansa[3]-ferrocenyl compounds while the same reaction conditions with the ruthenocene analogues led to an acyclic acetoxy-adduct. The mechanism of the cyclization has been studied by means of DFT calculations, showing that it proceeds through a Concerted Iodination Deprotonation (CID) step. This study not only expands further the chemistry of ynamides but also opens up new avenues in bioorganometallic chemistry by providing an exclusive access to an original ferrocephane moiety to be employed in this research field.
Unsupervised Scale-Invariant Multispectral Shape Matching (2022)

Alignment between non-rigid stretchable structures is one of the most challenging tasks in computer vision, as the invariant properties are hard to define, and there is no labeled data for real datasets. We present unsupervised neural network architecture based upon the spectral domain of scale-invariant geometry. We build on top of the functional maps architecture, but show that learning local features, as done until now, is not enough once the isometry assumption breaks. We demonstrate the use of multiple scale-invariant geometries for solving this problem. Our method is agnostic to local-scale deformations and shows superior performance for matching shapes from different domains when compared to existing spectral state-of-the-art solutions.
Microwave filters with improved stopband based on sub-wavelength resonators (2005)

The main aim of this paper is to demonstrate the potentiality of sub-wavelength resonators, namely, split-ring resonators, complementary split-ring resonators, and related structures to the suppression of undesired spurious bands in microwave filters, a key aspect to improve their rejection bandwidths. The main relevant characteristics of the cited resonators are their dimensions (which can be much smaller than signal wavelength at resonance) and their high-Q factor. This allows us to design stopband structures with significant rejection levels, few stages, and small dimensions, which can be integrated within the filter active region. By this means, no extra area is added to the device, while the passband of interest is virtually unaltered. A wide variety of bandpass filters, implemented in both coplanar-waveguide and microstrip technologies, have been designed and fabricated by the authors. The characterization of these devices points out the efficiency of the proposed approach to improve filter responses with harmonic rejection levels near 40 dB in some cases. It is also important to highlight that the conventional design methodology for the filters holds. For certain configurations, the presence of the resonators slightly lowers the phase velocity at the frequencies of interest with the added advantage of some level of reduction in device dimensions.
Translational Energies of CH3+, CHO+, CH2OH+, and CH3CO+ Ions from Oxygen‐Containing Molecules (1978)

Abstract The translational energies of CH 3 + , CHO + , CH 2 OH + , and CH 3 CO + ions from oxygen‐containing molecules have been measured by a new method in a time‐of‐flight mass spectrometer. The method is developed by which the energy can be readily determined from the analysis of the decay curve of ion. A relation between the translational energy of ions and the structure of source molecules was discussed.
Carotenes Produced by Alkaliphilic Yellow-pigmented Strains of Bacillus. (1991)

Weclassified several alkaliphilic strains of the genus Bacillus into three groups on the basis of cell-wall components, cation-requirement for growth, and other properties.1}