gebhart/patrepeval huggingface dataset:
О непредсказуемости результатов иммунотерапии и иммунопрофилактики COVID-19 (2020)

В работе проведен анализ возможности использования иммунотерапии и иммунопрофилактики в борьбе с COVID-19. Результаты, к которым может привести профилактическое или терапевтическое применение препаратов, содержащих антитела против вируса SARS-CoV-2, на наш взгляд, неоднозначны, а взаимодействие антител с коронавирусными антигенами (S-протеинами) может повлечь за собой не только нейтрализацию вируса, но и усиление его способности проникать в клетку хозяина. В работе сделан акцент на необходимости научного доказательства эффективности и безопасности планируемых к применению методов терапии и профилактики COVID-19.
Adaptive sidelobe nulling using digitally controlled phase-shifters (1976)

Adaptive null-steering arrays which use phase-only weights are examined. The optimal phase weightings are developed and the mathematical equations are reduced to a simplified computational form. Approximations for low sidelobe arrays allow more efficient computations and demonstrate the decomposition of the antenna pattern into a sum of patterns which place gain towards each directional emitter. Computer simulations and breadboard array measurements substantiate the mathematical development and indicate the practicality of the method.
PLASMA ARC VITRIFICATION OF FLY-ASHES FROM MUNICIPAL WASTE INCINERATION PLANT (2023)

Fly-ashes were processed in a plasma furnace where a DC arc is transferred either between a tungsten or a graphite electrode and the melt inside a graphite crucible acting as a bottom electrode,or between two twin plasma torches.<br> Fly-ashes from a municipal waste incineration plant were collected from the electrostatic precipitator before acid gas removal so that the chlorine and sulfur contents were around 10 &#37; and 2.5 &#37; respectively.<br> After preheating of the furnace, fly-ashes are fed through a screw-feeder with a feed-rate around 25 kg/h. Arc intensity was adjusted between 250 and 500 A; power input was from 20 to 70 kW; temperature inside the melt, measured by thermocouple, was between 1350 and 1550 &deg;C. Thermal transfers in the furnace were measured to check the energy balances. Off-gases exit the furnace through a post-combustion chamber to burn possible carbon oxide; then they cross a bag-filter before being washed by sodium hydroxide. More than 70 &#37; of the input material were melted to a glassy product in a compact form and 20 &#37; were collected in the bag filter as condensate. The rest of the input passed into the off-gas as permanent gases.<br> Analysis of the feed, of the glassy product and of the fume exhaust solids are given with the phase partitioning ratios of chemical elements. For example, in particular conditions, only about 1 &#37; of lead is trapped in the glassy product and even less for cadmium. The influence of reducing potential of the furnace atmosphere on metals contents in the glassy product is approached.<br> To assess environmental implications, the glassy products, similar to obsidian or basalt, were tested in accordance with French toxicity characteristic leaching procedure (X 31210).<br> Hydrometallurgical treatments have been applied to the fume collected in the bag-filter so that heavy metals are concentrated, as hydroxides, freed of chlorine, in a filter-cake which is only 3 &#37; of the initial fly-ash mass.This residue could be recycled in the arc furnace while the filtrate, mainly sodium chloride , must be ducted to the waste water treatment station.
Supplementary Figure 4 from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51 (2023)

Supplementary Figure 4 from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51
Optimizing PCR Detection of Zika Virus from Various Body Fluids (2018)

Current diagnostic protocols of acute Zika virus (ZIKV) infection focus on detection of viral RNA in serum or urine using reverse transcription quantitative polymerase chain reaction (RT-qPCR); however, detecting infection can be a challenge, given that 80% of people with acute ZIKV infection are asymptomatic, and the window to detect viremia in serum is short. The ability to extend that window is needed to detect ZIKV at later time points after infection, particularly in high-risk individuals such as pregnant women. We evaluated RNA extraction methods to optimize detection of ZIKV in various body fluids using RT-qPCR as a means of improving the analytical sensitivity of detection. We optimized methods for ZIKV RNA recovery from a number of body fluids by spiking with three varying concentrations of virus, then comparing recovery with that of spiked buffer control. RNA extraction protocols were adjusted as necessary for maximum RNA recovery. Adjustment of the elution step was essential for improved ZIKV RNA recovery from whole blood, saliva, vaginal secretions, and breast milk. Optimal recovery from urine samples required the addition of Urine Conditioning Buffer, and the use of RLT Plus buffer and RNeasy Mini Spin Columns was necessary for RNA extractions from semen samples. Optimized QIAamp MinElute Virus Spin Kit (QIAGEN, Valencia, CA) protocol followed by the singleplex ZIKV RT-qPCR assay provided a reliable method for detection of ZIKV RNA in a variety of biological samples. Improved diagnostics are crucial for timely detection and diagnosis, particularly during pregnancy when the consequences of ZIKV infection can greatly impact the developing fetus.
HYDRO GEOLOGICAL CONDITIONS OF DOIRANI LAKE BASIN. EXTERIOR INTERFERENCES AND RESULTS (2004)

In this paper the hydro geological conditions of the quaternary deposits of Doirani lake basin are represented. The surface and subsurface water balance for the years 1988-1990 are also calculated.During the period 1985-1998 decline of 3,77 m of the lake's level has been noticed. The fact that the lake does not appear to have any sign of restoration leads to many questions regarding to its existence, water balance, hydraulic conditions of the basin and the groundwater overexploretion Analyzing the available hydrological, geological, lithological data a water balance deficit of 101.23*106 m3 /year for the period 1988-1990 is calculated resulted from the groundwater overexploretion. At the same time the loss of water due to the decline of the lake's level have reached the amounts of 90.58*106 m3 /year.
Statistical Capability Study of a Helical Grinding Machine Producing Screw Rotors (2017)

Screw compressors depend for their efficiency and reliability on the accuracy of the rotors, and therefore on the machinery used in their production. The machinery has evolved over more than half a century in response to customer demands for production accuracy, efficiency, and flexibility, and is now at a high level on all three criteria. Production equipment and processes must be capable of maintaining accuracy over a production run, and this must be assessed statistically under strictly controlled conditions. This paper gives numerical data from such a study of an innovative machine tool and shows that it is possible to meet the demanding statistical capability requirements.
Cotton GalT1 Encoding a Putative Glycosyltransferase Is Involved in Regulation of Cell Wall Pectin Biosynthesis during Plant Development (2013)

Arabinogalactan proteins (AGPs), are a group of highly glycosylated proteins that are found throughout the plant kingdom. To date, glycosyltransferases that glycosylate AGP backbone have remained largely unknown. In this study, a gene (GhGalT1) encoding a putative β-1,3-galactosyltransferase (GalT) was identified in cotton. GhGalT1, belonging to CAZy GT31 family, is the type II membrane protein that contains an N-terminal transmembrane domain and a C-terminal galactosyltransferase functional domain. A subcellular localization assay demonstrated that GhGalT1 was localized in the Golgi apparatus. RT-PCR analysis revealed that GhGalT1 was expressed at relatively high levels in hypocotyls, roots, fibers and ovules. Overexpression of GhGalT1 in Arabidopsis promoted plant growth and metabolism. The transgenic seedlings had much longer primary roots, higher chlorophyll content, higher photosynthetic efficiency, the increased biomass, and the enhanced tolerance to exogenous D-arabinose and D-galactose. In addition, gas chromatography (GC) analysis of monosaccharide composition of cell wall fractions showed that pectin was changed in the transgenic plants, compared with that of wild type. Three genes (GAUT8, GAUT9 and xgd1) involved in pectin biosynthesis were dramatically up-regulated in the transgenic lines. These data suggested that GhGalT1 may be involved in regulation of pectin biosynthesis required for plant development.
Root Exudates Regulate Soil Fungal Community Composition and Diversity (2007)

Plants are in constant contact with a community of soil biota that contains fungi ranging from pathogenic to symbiotic. A few studies have demonstrated a critical role of chemical communication in establishing highly specialized relationships, but the general role for root exudates in structuring the soil fungal community is poorly described. This study demonstrates that two model plant species (Arabidopsis thaliana and Medicago truncatula) are able to maintain resident soil fungal populations but unable to maintain nonresident soil fungal populations. This is mediated largely through root exudates: the effects of adding in vitro-generated root exudates to the soil fungal community were qualitatively and quantitatively similar to the results observed for plants grown in those same soils. This effect is observed for total fungal biomass, phylotype diversity, and overall community similarity to the starting community. Nonresident plants and root exudates influenced the fungal community by both positively and negatively impacting the relative abundance of individual phylotypes. A net increase in fungal biomass was observed when nonresident root exudates were added to resident plant treatments, suggesting that increases in specific carbon substrates and/or signaling compounds support an increased soil fungal population load. This study establishes root exudates as a mechanism through which a plant is able to regulate soil fungal community composition.
The resin molded chip size package (MCSP) (2002)

The resin molded chip size package (MCSP), consisting of a polyimide/Cu film carrier with metal bumps, has been developed. The CSP having area-array type electrodes connected with the printed circuit board has been developed by many semiconductor companies. We have developed a resin molded CSP. The encapsulant used for this application has also been developed; it is unlike the conventional liquid type or transfer mold type. The molding method is also new and has been indigenously developed. Two new molding methods were designed: 1) the resin-mold and the connection between the semiconductor-chip and the carrier tape with the metal bumps were simultaneously carried out using the newly developed thermo-adhesive polyimide coated on the carrier tape before the connection; 2) this approach involved laminating the sheet on the semiconductor-chip with the new polyimide adhesive. The encapsulation and the reliability of MCSP were investigated and found to be excellent (resistance to corrosion, heat and stress), equal or superior to that of the conventional surface-mounted devices.
Process techniques for improving post-exposure delay stability in chemically amplified resists (1997)

The post-exposure delay (PED) stability of several chemically amplified DUV resists in unfiltered environments is shown to be strongly dependent on the standing wave intensity. The use of a bottom antireflective layer diminishes the rate of CD change for UVIIHS<SUP>TM</SUP>, UVIII<SUP>TM</SUP>, APEX-E and UV5<SUP>TM</SUP> resists by a factor of three or greater. Increasing the post exposure bake to diffuse outstanding waves results in a three to six fold improvement with UVIIHS, UVIII, UV5 and UV6<SUP>TM</SUP>. These resists show the greatest stability when soft baked at high temperatures to reduce the diffusion rate of airborne contaminants, and post-exposure baked at high temperatures to diffuse out the standing wave pattern.
Liquid Crystal Droplets as a Hosting and Sensing Platform for Developing Immunoassays (2011)

In this paper, we report an immunoassay in which probe proteins are immobilized on the surface of liquid crystal (LC) droplets rather than on solid surfaces. The advantage of this immunoassay is that the binding of antibodies to the probe proteins can be transduced by the LC droplets directly without the need for additional steps. For example, when we incubate the LC droplets decorated with immunoglobulin G (IgG) in a solution containing anti-IgG (AIgG), these droplets change their orientations from radial to bipolar configuration. In contrast, when we incubate the IgG-LC droplets in a solution containing anti-human serum albumin (AHSA), no changes are observed. The change of orientational configuration indicates the formation of the antigen-antibody immunocomplex on the surface of the LC droplets. Using LC droplet immunoassays, we successfully detect antibody concentrations as low as 0.01 μg/mL for AIgG and 0.02 μg/mL for AHSA. Because the immunoassay using LC droplets is label-free and gives a unique optical response, it has the potential to be further developed as a portable and low-cost immunoassay.
ChemInform Abstract: Synthesis of Amino Acid Analogues of Citric Acid Siderophores. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effects of hemorrhage on interleukin-1 production. (1988)

Depression of lymphocyte proliferative response occurs after trauma and hemorrhage. Because abnormalities in interleukin-1 (IL-1) production can result in depression of mitogen-induced lymphocyte proliferation, we investigated the effects of unanesthetized hemorrhage on IL-1 generation. The capacity of peripheral blood monocytes to produce IL-1 increased more than five fold by 2 h after loss of 30% of the total blood volume and returned to normal by 12 h after hemorrhage. Removal of 15% of total blood volume did not result in any alterations in IL-1 production. These results show that the diminished lymphocyte proliferative response which occurs after unanesthetized hemorrhage was not due to decreased IL-1 production. The increase in IL-1 generation which occurs shortly after severe hemorrhage may play a role in mediating the acute phase reaction which follows hemorrhage and trauma.
Convergence theorem for a general class of power control algorithms (2002)

We consider the convergence issues of distributed power control algorithms for mobile cellular systems. A convergence theorem for power control algorithms of canonical type is proven. Our result generalizes Yates' (1995) framework and provides a new outlook on the problem. The general applicability of the theorem is demonstrated by showing that all the well-known algorithms are canonical. Furthermore, by devising a new discrete algorithm, we exemplify how the theorem can be used to aid new design.
EPIDEMIOLOGICAL FEATURES OF GLAUCOMA (1990)

From the Jules Stein Eye Institute, Department of Ophthalmology, University of California at Los Angeles, and the Division of Ophthalmology, Charles R. Drew University of Medicine and Science. Address correspondence to Dr Wilson, Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, CA 90024.
Sleep EEG in depression. (1980)

Depression is a common psychiatric disorder with sleep disturbance as a concomitant symptom. This paper selectively reviews the earlier, more global research and more recent studies with improved methodologies. Research has shown that EEG sleep changes (in particular, REM) can be used as an aid in differential diagnosis of depression and possibly as a way of treatment. It is speculated that an ultradian cycle disruption involving REM sleep mechanisms is related to primary depression.
[Traumatic internal carotid artery dissection due to compression by a helmet strap]. (2004)

It is well known that wearing a helmet can reduce the risk of head injury in a traffic accident. We report a case of traumatic cervical internal carotid artery dissection due to compression by the strap of a helmet after a motorcycle accident. A 21 year-old man fell off his motorcycle and his head was struck at the right parietal region. His helmet prevented head injury, but the helmet strap which was fixed around his neck compressed his cervical internal carotid artery. He lost consciousness and developed left hemiparesis two hours after being admitted to an emergency department. Cerebral angiography revealed dissection of he right cervical internal carotid artery. This lesion was treated successfully by stent placement two months after the accident. The cause of carotid dissection was thought to be compression of his neck by the helmet strap. If the strap of a helmet is fixed around the neck, it can cause carotid artery injury during an accident, so it can be concluded that the strap of a helmet should be fixed firmly at the chin.
Video from Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity (2023)

&lt;p&gt;Video CX&lt;/p&gt;
Reivindicación de la política en la formación de ciudadanos y alumnos de las facultades de educación (2016)

El objetivo esencial de este criterio es reivindicar la politica y la presencia de la Politica en la Educacion en la formacion universitaria de maestros, educadores y pedagogos. Se inicia con el elogio y alegato en favor de la politica describiendo su situacion en un tiempo en el que el capitalismo contemporaneo irrumpe en su lugar y genera vacios -debilidades del Estado y del espacio publico- que fomentan el desencanto y la desafectacion hacia la politica. Los desafios que entranan las formas emergentes de hacer politica a traves de las redes sociales son una razon mas, pero no la unica, que justifica la inclusion de la Politica de la Educacion en la formacion de los alumnos de las Facultades de Educacion. Por ultimo, se estudia la presencia de esa materia en los Grados universitarios de educacion.
A high stability ka-band radiometer for tropospheric water vapor measurements (2002)

The design of two new high stability microwave water vapor radiometers is presented along with a performance evaluation. The radiometers operate next to a spacecraft tracking station at NASA's Goldstone facility in California where they will be used to calibrate tropospheric path delay fluctuations during an upcoming gravity wave search experiment (GWE) involving the Cassini spacecraft. Observing frequencies of the radiometers are 22.2 GHz, 23.8 GHz, and 31.4 GHz, and the antenna beamwidth is 1 degree. The instruments are room temperature Dicke radiometers with additive noise injection for gain calibration. Design highlights include: (1) a practical temperature control system capable of stabilizing the entire receiver to a few millikelvin from day to night; (2) redundant noise diode injection circuits with 30 parts per million RF power stability; and (3) a voice coil actuated waveguide vane attenuator which is used as a high performance Dicke switch. Performance of the radiometers is evaluated from inter-comparisons of the two radiometers and from continuous tip-curve calibrations spanning nearly one year. Structure function analysis of the intercomparison data indicates that the brightness temperature stability of these radiometers is better than 0.01 Kelvin on 1,000 to 10,000 second time scales. Analysis of tip-curve calibrations indicate RMS errors of approximately 0.05 K on 30-day time scales, and 0.15 K on one year time scales.
Influence of the structure of the orientation preference map on the responses of V1 neurons (2003)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2003.
A Gasoline Additive Concentrate Removes Combustion Chamber Deposits and Reduces Vehicle Octane Requirement (1983)

&lt;div class="htmlview paragraph"&gt;Combustion chamber deposits accumulate in a new gasoline engine and can result in an octane requirement increase (ORI) of as much as 8 to 10 octane numbers. In some cases, a higher octane fuel is required to prevent engine knock (detonation).&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;A unique new additive concentrate has been developed which reduces combustion chamber deposits and lowers the engine's octane requirement. This new additive is an ashless dispersant based on polyether amine chemistry. Laboratory and fleet test results show that after using one tankful of gasoline treated with additive, the engine's octane requirement is typically reduced by 30% to 40% of the original engine ORI. This benefit lasts for several thousand kilometers until the deposits reestablish themselves in the combustion chamber.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In addition to the octane requirement decrease (ORD) effect, other benefits from the use of this additive include engine run-on reduction and intake system deposit cleanup.&lt;/div&gt;
Hierarchical assembly of the MLL1 core complex within a biomolecular condensate regulates H3K4 methylation (2019)

ABSTRACT The enzymes that regulate histone H3 lysine 4 (H3K4) methylation are required for cellular differentiation and development and are often mutated in human disease. Mixed Lineage Leukemia protein-1 (MLL1) is a member of the SET1 family of histone H3 lysine 4 methyltransferases, which require interaction with a conserved sub-complex consisting of W DR5, R bBP5, A sh2L and D PY30 (WRAD 2 ) for maximal activity. It is currently unclear how assembly of SET1 family complexes is involved in the spatiotemporal control of H3K4 methylation in eukaryotic genomes. In this investigation, we systematically characterized the hydrodynamic and kinetic properties of a reconstituted human MLL1 core complex and found that its assembly is highly concentration and temperature dependent. Consistent with a hierarchical assembly pathway, we found that the holo-complex assembles through interactions between the MW and RAD 2 sub-complexes, which is correlated with enzymatic activity. Surprisingly, we found that the disassembled state is favored at physiological temperatures, and that this thermodynamic barrier can be overcome under conditions that induce high-local concentrations of subunits in phase separated compartments. Combining this data with the observation that MLL1 primary sequence contains large regions of intrinsic disorder, we propose a “swinging-domain” model in which the interaction between a tethered MW subcomplex and multiple nucleosome-RAD 2 complexes is regulated by the rapid formation or dissolution of biomolecular condensates, such as occurs in transcription factories. This model provides an elegant “switch-like” mechanism for spatiotemporal control of H3K4 methylation within eukaryotic genomes.
Design and operation of a high pulse rate intense ion beam diode (1995)

Virtually all practical applications for intense ion beams require that the beam pulses be generated at high repetition rates. This paper reports the development of the first high pulse rate, long-lived ion beam diode. It is a magnetically insulated diode which has produced ∼75 keV proton and carbon beam pulses of 1.0–2.5 A/cm2 and 100 ns duration at up to 90 Hz in four pulse bursts. It has also produced 125 keV, 5 A/cm2 Ar beams at a steady 1 pulse per 30 s for over 1000 pulses between failures in many runs. This diode employs a magnetically confined anode plasma ion source, and the high repetition rate pulsed power systems are based upon saturable magnetic switching.
Phase‐Vanishing Methodology for Efficient Bromination, Alkylation, Epoxidation, and Oxidation Reactions of Organic Substrates. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.