gebhart/patrepeval huggingface dataset:
Comparative Coreflood Studies for Precipitation and Adsorption Squeeze with PPCA as the Scales Inhibitor (2003)

Abstract Comparative adsorption and precipitation squeezes carried out on field core materials demonstrate that significant lifetime enhancement is achievable for precipitation squeeze with respect to more conventional adsorption squeeze. Coreflood tests have been carried out under reservoir conditions (135°C) employing a poly-phosphinocarboxylate (PPCA) as the scales inhibitor. Field treatment simulations, carried out starting from coreflood data and considering the characteristics of a North Sea formation taken as the reference, confirmed the higher performance, in term of squeeze lifetime, of the precipitation squeeze with respect to adsorption. The results pointed out the importance of choosing the appropriate formulation once the operative conditions are known, in order to promote the inhibitor precipitation into the formation. Some implications of these results for the optimization of the precipitation squeeze technology for field applications, with particular emphasis to formation damage, are also discussed.
Trace Lead Analysis Employing a Dual-Channel Single-Crystal X-Ray Spectrometer (1970)

A single-channel x-ray spectrometer has been converted to a two-channel instrument. Two separate planes in a single lithium fluoride crystal are employed to reflect, simultaneously, two portions of the x-ray spectrum. The instrument has been used to measure trace quantities of lead in the form of particulate matter as an air pollutant. One crystal plane was used to reflect the lead L α emission line while the second plane reflected background radiation near that line.
Adaptive learning and mining for data streams and frequent patterns (2009)

This thesis is devoted to the design of data mining algorithms for evolving data streams and for the extraction of closed frequent trees. First, we deal with each of these tasks separately, and then we deal with them together, developing classification methods for data streams containing items that are trees. In the data stream model, data arrive at high speed, and the algorithms that must process them have very strict constraints of space and time. In the first part of this thesis we propose and illustrate a framework for developing algorithms that can adaptively learn from data streams that change over time. Our methods are based on using change detectors and estimator modules at the right places. We propose an adaptive sliding window algorithm ADWIN for detecting change and keeping updated statistics from a data stream, and use it as a black-box in place or counters or accumulators in algorithms initially not designed for drifting data. Since ADWIN has rigorous performance guarantees, this opens the possibility of extending such guarantees to learning and mining algorithms. We test our methodology with several learning methods as Naíve Bayes, clustering, decision trees and ensemble methods. We build an experimental framework for data stream mining with concept drift, based on the MOA framework, similar to WEKA, so that it will be easy for researchers to run experimental data stream benchmarks. Trees are connected acyclic graphs and they are studied as link-based structures in many cases. In the second part of this thesis, we describe a rather formal study of trees from the point of view of closure-based mining. Moreover, we present efficient algorithms for subtree testing and for mining ordered and unordered frequent closed trees. We include an analysis of the extraction of association rules of full condence out of the closed sets of trees, and we have found there an interesting phenomenon: rules whose propositional counterpart is nontrivial are, however, always implicitly true in trees due to the peculiar combinatorics of the structures. And finally, using these results on evolving data streams mining and closed frequent tree mining, we present high performance algorithms for mining closed unlabeled rooted trees adaptively from data streams that change over time. We introduce a general methodology to identify closed patterns in a data stream, using Galois Lattice Theory. Using this methodology, we then develop an incremental one, a sliding-window based one, and finally one that mines closed trees adaptively from data streams. We use these methods to develop classification methods for tree data streams.
PDT-based combinations in overcoming chemoresistance from stromal and heterotypic cellular communication (Conference Presentation) (2017)

Targeting the molecular and cellular cues that influence treatment resistance in tumors is critical to effectively treating unresponsive populations of stubborn disease. The informed design of mechanism-based combinations is emerging as increasingly important to targeting resistance and improving the efficacy of conventional treatments, while minimizing toxicity. Photodynamic therapy (PDT) has been shown to synergize with conventional agents and to overcome the evasion pathways that cause resistance. Increasing evidence shows that PDT-based combinations cooperate mechanistically with, and improve the therapeutic index of, traditional chemotherapies. These and other findings emphasize the importance of including PDT as part of comprehensive treatment plans for cancer, particularly in complex disease sites. Identifying effective combinations requires a multi-faceted approach that includes the development of bioengineered cancer models and corresponding image analysis tools. The molecular and phenotypic basis of verteporfin-mediated PDT-based enhancement of chemotherapeutic efficacy and predictability in complex 3D models for ovarian cancer will be presented.
Identification of Peptide Mimotope Ligands for Natalizumab (2018)

Mimotope peptides selected from combinatorial peptide libraries can be used as capture reagents for immunoassay detection of therapeutic monoclonal antibodies (mAbs). We report the use of phage display libraries to identify peptide ligands (Veritopes<sup>TM</sup>) that bind natalizumab, a therapeutic mAb indicated for use in multiple sclerosis. PKNPSKF is identified as a novel natalizumab-binding motif, and peptides containing this motif demonstrated utility as capture reagents in enzyme-linked immunosorbent assays (ELISAs). A peptide containing the identified motif was shown to be competitive with the natural ligand (α4-integrin) and a neutralizing anti-idiotype antibody for natalizumab binding, indicating that Veritopes<sup>TM</sup> act as surrogate ligands that bind the antigen binding site of natalizumab. Affinity maturation further confirmed the motif sequence and yielded peptides with greater apparent affinity by ELISA. Veritopes<sup>TM</sup> are promising assay reagents for therapeutic drug level monitoring.
Single (Primitive) Ventricle (1969)

Single ventricle is that condition in which both atrioventricular (A-V) orifices enter a common ventricular sinus, from which the arterial trunks emerge with their coni. The following types of single ventricle were found: (1) with regular (noninverted) transposition in levocardia; (2) with inverted transposition in levocardia; (3) with normal position of arterial trunks in levocardia; (4) in dextrocardia, and (5) in mesocardia. This entity is differentiated from common ventricle which is basically a heart with a large ventricular septal defect. Single ventricle does not include mitral and tricuspid atresia by definition, nor does it include straddling tricuspid orifice, in which two distinct ventricles are present. The concept of single ventricle herein defined differs from de la Cruz and Miller's concept of double-inlet left ventricle which includes straddling tricuspid orifice. Embryologically in single ventricle we are dealing with persistence of the primitive state of the bulboventricular loop, due to a lack of expansion of the atrial canal to the right during the process of absorption of the bulbus.
Computer architecture and implementation of vision-based real-time lane sensing (2003)

Lane sensing is the detection of lane boundaries from a video image of the roadway and the determination of the vehicle's position and orientation with respect to the lane. The detection of lane boundaries involves the digital processing of a roadway image to bring out points comprising the lane edge and a search of the processed images to find those points. Lane sensing supports several other functions, including collision warning, collision avoidance, driving performance monitoring and lane control. This paper describes the implementation of the two algorithms developed to achieve lane sensing in real-time on board a vehicle. This required developing the computer architecture, electronics and software to perform the processing steps in the algorithms. Attention was given to multitasking, multiprocessing and interprocess communication. In particular, use of the VME bus provides an open architecture and the disc-based real-time operating system provides multitasking and a flexible environment. The lane sensing system was installed in a vehicle and the real-time implementation was demonstrated on a test track and limited access highways.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Pindolol augmentation of serotonin reuptake inhibitors for the treatment of depressive disorder: a systematic review (2008)

Clinical response at time points up to 6 weeks as defined by >50% depression scale score reduction was extracted for each trial as possible. Eleven studies were identified including unpublished data. The pooled odds ratios for dichotomous response to treatment at time points from 1 to 6 weeks were 2.39 (95% CI 1.40-4.06), 2.39 (1.74-3.29), 1.94 (1.46-2.58), 1.59 (1.16-2.18), 1.42 (0.87-2.31) and 1.28 (0.91-1.81). Time-to-event analysis showed a greater response with pindolol augmentation versus placebo (P = 0.04). There was significant heterogeneity between studies at some time points. Dropout rates did not significantly differ between treatment arms. This review suggests an overall beneficial clinical effect of pindolol augmentation, most clearly up to 4 weeks of treatment.
kripodb: v1.2.2 (2016)

Library to interact with Kripo fragment, fingerprint and similarity data files. KRIPO stands for Key Representation of Interaction in POckets, see reference for more information. Added Added sub command to read fpneigh formatted distance matrix file (#14)
Study of whispering gallery modes in anisotropic single-crystal dielectric resonators (1994)

The Rayleigh-Ritz method and the finite element method nongenerating spurious solutions are employed for analysis of whispering gallery modes (WGMs) in cylindrical single-crystal anisotropic dielectric resonators. These methods allow accurate computation of the resonant frequencies, the Q-factors (depending on the dielectric and on the conductor losses), and the electromagnetic field distributions for all WGMs in the presence of additional elements like metal shields, MIC substrate, or supports. Different families of modes are studied both theoretically and experimentally. The mode coupling phenomenon is investigated. A WGM single-crystal quartz resonator is presented having an unloaded Q-factor greater than 30000 at about 100 GHz, including radiation and dielectric losses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Three-Dimensional Upper Limb Movements in Cerebellar Ataxia (2020)

We analyzed angular kinematics and joint torques of multi-joint arm movements in 3D space in healthy subjects and in patients (n = 9) with cerebellar degenerative disorders. Point-to-point movements at various movement velocities were recorded using an infrared tracking system (E.L.I.T.E.) with position markers attached to the shoulder, elbow, wrist, and hand. An inverse dynamics approach modeling the upper limb as three interconnected rigid links was employed to compute net joint torques (NET), gravitational torques (GRA), interactive motion-dependent torques (MDT), and muscle torques (MUS). Peak hand velocity, as well as peak hand acceleration and deceleration were similar to normals during slow movements but were smaller for moderate and fast movements. As compared to normal subjects, peak angular deceleration at the elbow joint was delayed in the patients when attempting fast movements. While altering movement velocities had little or no effect on angular displacement of elbow and shoulder joints in normal subjects, patients exhibited overshooting motions at both joints (hypermetria) that systematically increased with movement velocity. In both groups, muscular forces and motion-dependent torques at shoulder and elbow joint increased non-linearly with increasing hand velocities, however peak muscular force production at the elbow joint was smaller in patients. Our data suggest that dyscoordination of upper limb movements in cerebellar ataxia, in addition to deficient temporal control of movement variables, is associated with an insufficient production of task-adequate levels of muscular force during movements. We hypothesize that cerebellar patients have difficulties compensating for high levels of motion-dependent interactive torques generated during fast movements of a multi-segmented limb.
Oligosaccharides fractionation cascades with 3 outlet streams (2019)

Fructooligosaccharides (FOS) were fractionated using nanofiltration cascades. Instead of creating one product and a residual stream, we report on configurations that create 3 separate product streams rich in: (1) monosaccharides (DP1), (2) DP3 and (3) DP ≥ 5. We developed a modular system allowing different operating pressures and membrane types at each stage. Two possible alternative configurations were assessed for a 3-stage cascade both experimentally and via simulation. The simulation was performed using a steady state model and was in a good agreement with the experimental data. Using the simulation model, the system was optimized towards 4 and 5 stage cascades. All designs were evaluated based on the purities and yields of 3 components of interest in the corresponding product streams. Selecting the correct set up, the cascade was able to reach maximum purity of monosaccharides to 66 wt% (from 9 wt%), DP3 to 33 wt% (from 24 wt%) and DP ≥ 5 to 54 wt% (from 34 wt%). Increasing the number of stages improved the maximum purities of the 3 fractions. However, a fifth stage did not increase the purification and the best purities were found using 4-stage rather than 5-stage cascades.
Microbiological burden on the surfaces of the AIMP spacecraft, part 1 (1966)

Decontamination and microbiological monitoring of surfaces of Anchored Interplanetary Monitoring Platform spacecraft
ChemInform Abstract: The Li—Si—(O)—N System Revisited: Structural Characterization of Li21Si3N11 and Li7SiN3O. (2014)

Abstract The compounds Li 2 SiN 2 , Li 5 SiN 3 , Li 18 Si 3 N 10 , Li 21 Si 3 N 11 , and Li 7 SiN 3 O are prepared from powder mixtures of Li 3 N, Si 3 N 4 , and Li 2 O by varying reaction temperature and time as well as Li/Si and O/Si ratios (800—900 °C, 0.3—4 h).
On the Characteristics of Degree Adverbs Used in Luoyang Dialect (2011)

Degree adverbs are indispensible to language expressions in Chinese.As a smaller branch of Henan dialect,Luoyang dialect has the characteristics of its own though it shares many other features with mandarin Chinese.According to Mr.FAN Xiao′s Principle of Three-plane,the special feature of Luoyang dialect shows itself in the utmost expression of emotional feelings,emphatic affirmativeness,exaggerated overtone;high frequency of ellipsis,inversion,colloquialism,and so on.
Copolyethersulfones of 1,4:3,6-dianhydrohexitols and bisphenol A (2016)

The synthesis of biosourced copolyethersulfones by polycondensation of 1,4:3,6-dianhydrohexitol monomers and bisphenol A is reported. Structures and properties of these copolymers were investigated in each case. In the first part, the impact of the position of the two hydroxyl groups of isosorbide, isomannide, and isoidide is discussed. In the second part, we focused on improving the cost/thermal properties balance by introducing controlled proportions of bisphenol A as comonomer. The addition of bisphenol A serves two purposes. The first one is to maintain good thermal and mechanical properties of resulting copolymers. The second reason is to insure low-cost route to copolyethersulfones for a potential use in industrial applications. All the products have been fully characterized by NMR spectroscopy, MALDI-TOF spectrometry, and viscosimetry. The thermal properties were studied by differential scanning calorimetry (DSC).
Adrenomedullin 2 (ADM2) Regulates Mucin 1 at the Maternal-Fetal Interface in Human Pregnancy1 (2015)

Association of an altered expression of placental mucin 1 (MUC1) with first-trimester spontaneous abortion and its regulation in placenta by an invasion-promoting peptide, adrenomedullin 2 (ADM2), is not known. The objective of this study was to assess 1) the association of MUC1 mRNA expression in the placental villi and decidua with first-trimester spontaneous abortion, 2) the effects of ADM2 on the expression of MUC1 in trophoblast cells in the presence or absence of hypoxia, 3) the effects of ADM2 on expression of MUC1 in decidual stromal cells (DSCs), and 4) if ADM2 regulates the expression of MUC1 and MMP2 protein in trophoblastic spheroids. Data demonstrate that 1) expression of MUC1 mRNA in villous tissue is higher in spontaneous abortion compared to age-matched electively terminated pregnancies (P > 0.05), 2) ADM2 decreases the expression of MUC1 mRNA and protein in trophoblast cells and spheroids with concomitant increases in MMP2 immunoreactivity in the spheroids, 3) ADM2 decreases hypoxia-induced increases in MUC1 immunoreactivity in trophoblast cells, 4) decidual MUC1 mRNA expression is lower in spontaneous compared to elective abortions (P < 0.05), and 5) DSCs express MUC1 mRNA and protein and ADM2 decreases the expression of MUC1 mRNA and protein in DSCs. Taken together, this study demonstrates that first-trimester spontaneous abortion is associated with increases in MUC1 expression in villi and decreases in the decidual tissues, and suggests that ADM2 may contribute to the physiology of embryo implantation and placental growth via increasing MMP2 and decreasing MUC1 expression to facilitate trophoblast invasion.
Strikes By International Officials : Smith v. The Secretary-General of the United Nations (1980)

This article examines legal aspects of labor disputes in international organizations.
Xylanase production by endophyticAspergillus nigerusing pentose-rich hydrothermal liquor from sugarcane bagasse (2015)

Fungal xylanases have been widely studied and various production methods have been proposed using submerged and solid-state fermentation. This class of enzyme is used to supplement cellulolytic enzyme cocktails in order to enhance the enzymatic hydrolysis of plant cell walls. The present work investigates the production of xylanase and other accessory enzymes by a recently isolated endophytic Aspergillus niger DR02 strain, using the pentose-rich liquor from hydrothermal pretreatment of sugarcane bagasse as carbon source. Batch and fed-batch submerged cultivation approaches were developed in order to minimize the toxicity of the liquor and increase enzyme production. Maximum xylanase activities obtained were 458.1 U/mL for constant fed-batch, 428.1 U/mL for exponential fed-batch, and 264.37 U/mL for pulsed fed-batch modes. The results indicated that carbon-limited fed-batch cultivation can reduce fungal catabolite repression, as well as overcome possible negative effects of toxic compounds present in the pentose-rich liquor. Enzymatic panel and mass spectrometric analyses of the fed-batch A. niger secretome showed high levels of xylanolytic enzymes (GH10, GH11, and GH62 Cazy families), together with cellobiohydrolase (G6 and GH7), β-glucosidase, β-xylosidase (GH3), and feruloyl esterase (CE1) accessory enzyme activities. The yields of glucose and xylose from enzymatic hydrolysis of hydrothermally pretreated sugarcane bagasse increased by 43.7 and 65.3%, respectively, when a commercial cellulase preparation was supplemented with the A. niger DR02 constant fed-batch enzyme complex.
A Whole-Body Musculoskeletal Model of the Mouse (2021)

Neural control of movement cannot be fully understood without careful consideration of interactions between the neural and biomechanical components. Recent advancements in mouse molecular genetics allow for the identification and manipulation of constituent elements underlying the neural control of movement. To complement experimental studies and investigate the mechanisms by which the neural circuitry interacts with the body and the environment, computational studies modeling motor behaviors in mice need to incorporate a model of the mouse musculoskeletal system. Here, we present the first fully articulated musculoskeletal model of the mouse. The mouse skeletal system has been developed from anatomical references and includes the sets of bones in all body compartments, including four limbs, spine, head and tail. Joints between all bones allow for simulation of full 3D mouse kinematics and kinetics. Hindlimb and forelimb musculature has been implemented using Hill-type muscle models. We analyzed the mouse whole-body model and described the moment-arms for different hindlimb and forelimb muscles, the moments applied by these muscles on the joints, and their involvement in limb movements at different limb/body configurations. The model represents a necessary step for the subsequent development of a comprehensive neuro-biomechanical model of freely behaving mice; this will close the loop between the neural control and the physical interactions between the body and the environment.
Using High-Resolution Airborne and Satellite Imagery to Assess Crop Growth and Yield Variability for Precision Agriculture (2012)

With increased use of precision agriculture techniques, information concerning within-field crop yield variability is becoming increasingly important for effective crop management. Despite the commercial availability of yield monitors, many crop harvesters are not equipped with them. Moreover, yield monitor data can only be collected at harvest and used for after-season management. On the other hand, remote sensing imagery obtained during the growing season can be used to generate yield maps for both within-season and after-season management. This paper gives an overview on the use of airborne multispectral and hyperspectral imagery and high-resolution satellite imagery for assessing crop growth and yield variability. The methodologies for image acquisition and processing and for the integration and analysis of image and yield data are discussed. Five application examples are provided to illustrate how airborne multispectral and hyperspectral imagery and high-resolution satellite imagery have been used for mapping crop yield variability. Image processing techniques including vegetation indices, unsupervised classification, correlation and regression analysis, principal component analysis, and supervised and unsupervised linear spectral unmixing are used in these examples. Some of the advantages and limitations on the use of different types of remote sensing imagery and analysis techniques for yield mapping are also discussed.