gebhart/patrepeval huggingface dataset:
Elimination of threading dislocations inα-Ga2O3by double-layered epitaxial lateral overgrowth (2020)

We demonstrated double-layered epitaxial lateral overgrowth of α-Ga2O3 by halide vapor phase epitaxy. The second ELO α-Ga2O3 were regrown epitaxially and selectively through the windows of the patterned masks which were prepared on an ELO α-Ga2O3. The ELO islands coalesced step-by-step due to the nested-structure mask pattern. No threading dislocation was found by TEM not only above the masks but also above the windows of the second ELO pattern. The dislocation density was estimated to be less than 5 × 106 cm−2. We obtained a continuous crystalline α-Ga2O3 with a low density of dislocations in the entire second-ELO surface.
Purification and characterization of murine lipopolysaccharide-binding protein (1993)

The serum protein lipopolysaccharide (LPS)-binding protein (LBP) seems to play an important role in regulating host responses to LPS. Complexes of LPS and LBP form in serum and stimulate monocytes, macrophages, or polymorphonuclear leukocytes after binding to CD14. Previous reports have described the structure and properties of LBP from human and rabbit sera. Since mice are used in some experimental models of endotoxemia or gram-negative bacterial infections, information is needed about the properties of murine LBP. Murine LBP was purified by ion-exchange chromatography and high-pressure liquid chromatography; its NH2-terminal sequence (TNPGLVTRIT) was very similar to those of human and rabbit LBPs (80 to 90% amino acid identity). Murine LBP resembled LBPs from other species in that it promoted the binding of LPS to monocytes and enhanced the sensitivity of monocytes to LPS at least 100-fold. Mouse LBP, like rabbit and human LBPs, was found to be an acute-phase protein. Further in vivo studies with mice and anti-CD14 or anti-LBP reagents should help determine the role of LBP in response to LPS challenges.
A FULLY COMPLEX-VALUED RADIAL BASIS FUNCTION NETWORK AND ITS LEARNING ALGORITHM (2009)

In this paper, a fully complex-valued radial basis function (FC-RBF) network with a fully complex-valued activation function has been proposed, and its complex-valued gradient descent learning algorithm has been developed. The fully complex activation function, sech(.) of the proposed network, satisfies all the properties needed for a complex-valued activation function and has Gaussian-like characteristics. It maps C(n) --> C, unlike the existing activation functions of complex-valued RBF network that maps C(n) --> R. Since the performance of the complex-RBF network depends on the number of neurons and initialization of network parameters, we propose a K-means clustering based neuron selection and center initialization scheme. First, we present a study on convergence using complex XOR problem. Next, we present a synthetic function approximation problem and the two-spiral classification problem. Finally, we present the results for two practical applications, viz., a non-minimum phase equalization and an adaptive beam-forming problem. The performance of the network was compared with other well-known complex-valued RBF networks available in literature, viz., split-complex CRBF, CMRAN and the CELM. The results indicate that the proposed fully complex-valued network has better convergence, approximation and classification ability.
Supplementary Figure Legends, Materials and Methods, and Table 1 from Bisphosphonates Inhibit Stellate Cell Activity and Enhance Antitumor Effects of Nanoparticle Albumin–Bound Paclitaxel in Pancreatic Ductal Adenocarcinoma (2023)

&lt;p&gt;Supplementary Figure Legends, Materials and Methods, and Table 1. Supplementary Figure Legends, Supplementary Material and Methods for RNA isolation, cDNA synthesis, and quantification of RNA species, Supplementary Table 1. Primer Sequences.&lt;/p&gt;
Darstellung und Charakterisierung der nanoskaligen Vb‐Metalloxide M2O5 (M = V, Nb, Ta) (2004)

Abstract Die Darstellung nanoskaliger Vb‐Metalloxide M 2 O 5 (M = V, Nb, Ta) gelingt durch Polyol‐vermittelte Synthese. Diese erfolgt durch kontrollierte Hydrolyse der Alkoholate VO( i ‐OC 3 H 7 ) 3 , Nb(OC 2 H 5 ) 5 und Ta(OC 2 H 5 ) 5 in Diethylenglykol (DEG) bei 180 °C und liefert die Oxide in einem Größenbereich von etwa 10 bis 200 nm. Der monodisperse Habitus sowie das kolloidale Verhalten der nanoskaligen M 2 O 5 ‐Partikel in DEG und Wasser belegen die oberflächenaktive Wirkung des Diethylenglykols hinsichtlich Partikelwachstum und Partikelagglomeration. Thermogravimetrische Daten und Untersuchungen zur B.E.T.‐Oberfläche lassen auf eine der Größenordnung nach monomolekulare Belegung der M 2 O 5 ‐Partikeloberflächen mit DEG‐Molekülen schließen. Gemäß Elektronen‐ und Röntgenbeugungsbildern fallen die nanoskaligen Partikel nach der Synthese zunächst amorph an, durch eine moderate Temperaturbehandlung kann jedoch eine deutliche Erhöhung der Kristallinität erreicht werden.
Prediction of Irinotecan Pharmacokinetics by Use of Cytochrome P450 3A4 Phenotyping Probes (2004)

CYP3A4 phenotype, as assessed by midazolam clearance, is statistically significantly associated with irinotecan pharmacokinetics. Evaluation of midazolam clearance combined with UGT1A1*28 genotyping may assist with optimization of irinotecan chemotherapy.
Overview of optical 4D signal detection in turbid water by multi-dimensional integral imaging using spatially distributed and temporally encoded multiple light sources (2020)

We overview our recently published multi-dimensional integral imaging-based system for underwater optical signal detection. For robust signal detection, an optical signal propagating through the turbid water is encoded using multiple light sources and coded with spread spectrum techniques. An array of optical sensors captures video sequences of elemental images, which are reconstructed using multi-dimensional integral imaging followed by a 4D correlation to detect the transmitted signal. The area under the curve (AUC) and the number of detection errors were used as metrics to assess the performance of the system. The overviewed system successfully detects an optical signal under higher turbidity conditions than possible using conventional sensing and detection approaches.
ITERATIVE SORTING FOR 4DCT IMAGES BASED ON INTERNAL ANATOMY MOTION (2007)

Geometric uncertainties caused by respiratory motion complicate radiotherapy treatment planning. Therefore 4D CT imaging is important in characterizing anatomy motion during breathing. Current 4D CT imaging techniques using multislice CT scanners involve multiple scans at several axial positions and retrospective sorting processes. Most sorting methods are based on externally monitored signals recorded by external monitoring instruments, which may not always accurately catch the actual breathing status and may lead to severe discontinuity artifacts in the sorted CT volumes. We propose a method to reconstruct time-resolved CT volumes based on internal motion to avoid the inaccuracies caused by external breathing signals. In our method, we iteratively sort the 4D CT slices using internal motion based breathing indices. In each iteration, respiratory motion is estimated by updating a motion model to best match a deformed reference volume to each moving multi-slice sub-volumes. The breathing indices as well as the reference volumes are refined for each iteration based on the currently estimated respiratory motion. An example is presented to illustrate the feasibility of our 4D CT sorting method without using any external motion monitoring systems.
Animal Feed Antibiotic Use Raises Drug Resistance Fear (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Monte Carlo filtering on Lie groups (2002)

We propose a nonlinear filter for estimating the trajectory of a random walk on a matrix Lie group with constant computational complexity. It is based on a finite-dimensional approximation of the conditional distribution of the state-given past measurements-via a set of fair samples, which are updated at each step and proven to be consistent with the updated conditional distribution. The algorithm proposed, like other Monte Carlo methods, can in principle track arbitrary distributions evolving on arbitrarily large state spaces. However, several issues concerning sample impoverishment need to be taken into account when designing practical working systems.
Evaluation of Serum Fibrinogen, Plasminogen,α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM (2014)

BACKGROUND. Diabetic retinopathy (DR) is the leading cause of blindness in the world. Retinopathy can still progress despite optimal metabolic control. The aim of the study was to determine whether different degrees of DR (proliferative or nonproliferative) were associated with abnormally modulated hemostatic parameters in patients with T1DM. METHOD. 52 T1DM patients and 40 healthy controls were enrolled in the study. Patients were subdivided into three categories. Group I was defined as those without retinopathy, group II with NPRP, and group III with PRP. We compared these subgroups with each other and the control group (Group IV) according to the serum fibrinogen, plasminogen, alpha2-anti-plasmin ( α2-anti-plasmin), and PAI. RESULTS. We detected that PAI-1, serum fibrinogen, and plasminogen levels were similar between the diabetic and control groups (P = 0.209, P = 0.224, and P = 0.244, resp.), whereas α2-anti-plasmin was higher in Groups I, II, and III compared to the control group (P < 0.01, P < 0.05, and P < 0.001, resp.). There was a positive correlation between serum α2-anti-plasmin and HbA1c levels (r = 0,268, P = 0.031). CONCLUSION. To our knowledge there is scarce data in the literature about α2-anti-plasmin levels in type 1 diabetes. A positive correlation between α2-anti-plasmin with HbA1c suggests that fibrinolytic markers may improve with disease regulation and better glycemic control.
Rewiring cell-free metabolic flux inE. colilysates using a block—push—pull approach (2023)

Cell-free systems can expedite the design and implementation of biomanufacturing processes by bypassing troublesome requirements associated with the use of live cells. In particular, the lack of survival objectives and the open nature of cell-free reactions afford engineering approaches that allow purposeful direction of metabolic flux. The use of lysate-based systems to produce desired small molecules can result in competitive titers and productivities when compared to their cell-based counterparts. However, pathway crosstalk within endogenous lysate metabolism can compromise conversion yields by diverting carbon flow away from desired products. Here, the 'block-push-pull' concept of conventional cell-based metabolic engineering was adapted to develop a cell-free approach that efficiently directs carbon flow in lysates from glucose and toward endogenous ethanol synthesis. The approach is readily adaptable, is relatively rapid and allows for the manipulation of central metabolism in cell extracts. In implementing this approach, a block strategy is first optimized, enabling selective enzyme removal from the lysate to the point of eliminating by-product-forming activity while channeling flux through the target pathway. This is complemented with cell-free metabolic engineering methods that manipulate the lysate proteome and reaction environment to push through bottlenecks and pull flux toward ethanol. The approach incorporating these block, push and pull strategies maximized the glucose-to-ethanol conversion in an <i>Escherichia coli</i> lysate that initially had low ethanologenic potential. A 10-fold improvement in the percent yield is demonstrated. To our knowledge, this is the first report of successfully rewiring lysate carbon flux without source strain optimization and completely transforming the consumed input substrate to a desired output product in a lysate-based, cell-free system.
Time-course analysis of the effect of embedded metal on skeletal muscle gene expression (2020)

As a consequence of military operations, many veterans suffer from penetrating wounds and long-term retention of military-grade heavy metal fragments. Fragments vary in size and location, and complete surgical removal may not be feasible or beneficial in all cases. Increasing evidence suggests retention of heavy metal fragments may have serious biological implications, including increased risks for malignant transformation. Previous studies assessed the tumorigenic effects of metal alloys in rats, demonstrating combinations of metals are sufficient to induce tumor formation after prolonged retention in skeletal muscle tissue. In this study, we analyzed transcriptional changes in skeletal muscle tissue in response to eight different military-relevant pure metals over 12 mo. We found that most transcriptional changes occur at 1 and 3 mo after metal pellets are embedded in skeletal muscle and these effects resolve at 6 and 12 mo. We also report significant immunogenic effects of nickel and cobalt and suppressive effects of lead and depleted uranium on gene expression. Overall, skeletal muscle exhibits a remarkable capacity to adapt to and recover from internalized metal fragments; however, the cellular response to chronic exposure may be restricted to the metal-tissue interface. These data suggest that unless affected regions are specifically captured by biopsy, it would be difficult to reliably detect changes in muscle gene expression that would be indicative of long-term adverse health outcomes.
Portable magnetic resonance sensors and methods for noninvasive disease diagnostics (2019)

This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Order Parameter (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Health‐related quality of life following haematopoietic cell transplantation: patient education, evaluation and intervention (2009)

Health-related quality of life (QOL) is a vital concern in the pre-treatment consent process and post-treatment care of recipients of haematopoietic cell transplantation (HCT). We propose that comprehensive care of such patients requires an integration of knowledge of the impact of HCT on QOL, assessment of QOL, as well as resources available for intervention. This knowledge may significantly improve patient care when incorporated into daily clinical practice in the transplant setting. As a framework for this approach, this article reviews the literature on QOL after allogeneic and autologous HCT for adults with haematological malignancies. We then discuss evidence in support of the beneficial impact of clinical QOL assessment, and finally evaluate behavioural interventions that show promise to maintain or improve QOL after HCT.
Operative Blood Loss Independently Predicts Recurrence and Survival After Resection of Hepatocellular Carcinoma (2009)

The magnitude of EBL during HCC resection is related to biologic characteristics of the tumor as well as the extent of surgery. Increased intraoperative blood loss during HCC resection is an independent prognostic factor for tumor recurrence and death.
A new immunoglobulin sub-class in the sheep. (1969)

A new immunoglobulin sub-class, IgG1(A), has been defined in the sheep with the aid of an antibody prepared by immunizing goats with sheep IgG. The sub-class antigen is located on the Fc fragment and is carried by approximately 20 per cent of the IgG1 molecules. IgG1(A) is lacking in the serum of some sheep and this appears to be under X-linked genetic control. No marked breed distribution was found for IgG1(A) negativity.
Preface (1993)

Pin-in-hole technology (ceramic electronic-circuit-chip carriers with pins that are inserted into the plated through holes of epoxy-glass printed circuit cards) dominated IBM subsystem-assembly technology through the 1960s and 1970s. The 1980s saw the emergence of surface mount technology (SMT), peripherally leaded components mounted on the surface of printed circuit cards. SMT no longer required large plated through holes in the circuit cards to accommodate chip carriers with pins and thereby provided higher-efficiency packaging. In the 1990s the need for packages with higher and higher I/O counts is being driven by the increased circuit density of CMOS device technology. These 1/0 demands are driving peripherally leaded surface-mounted components to smaller pitches (lead-to-lead spacing), which in turn has decreased circuit card assembly yields through added process complexity, and has thus increased the overall device packaging cost.
Anti-Stokes luminescence in bismuth-doped high-germania core fibres (2019)

This paper presents a study of anti-Stokes luminescence in optical fibres with a bismuth-doped ∼50%GeO2 – 50%SiO2 glass core under IR excitation. The anti-Stokes luminescence intensity has been measured as a function of temperature in the range 77 – 300 K. From these data, we have evaluated the activation energy for the thermal quenching of anti-Stokes luminescence in the visible and IR spectral regions. A mechanism of anti-Stokes luminescence in this type of optical fibre has been proposed.
Spectral Efficient Signaling for Half-duplex Relay Channels (2006)

We study two-hop communication protocols where one or two relay terminals assist in the communication between two transceiver terminals. All terminals operate in half-duplex mode, i.e., may not receive and transmit simultaneously at the same time and frequency. This leads to a loss in spectral efficiency due to the pre-log factor 1/2 in corresponding expressions for the achievable rate (capacity). We propose and analyze two relaying protocols that avoid the pre-log factor 1/2 but still work with halfduplex relays. Firstly, we consider a relaying protocol where two half-duplex relays, either amplify-and-forward (AF) or decodeand-forward (DF), alternately forward messages from a source terminal to a destination terminal (two-path relaying). It is shown that the protocol can recover a significant portion of the halfduplex loss. Secondly, we propose a relaying protocol where a bidirectional connection between two transceiver terminals is established via one half-duplex AF or DF relay (two-way relaying). It is shown that the sum rate of the two-way half-duplex AF relay channel achieves the rate of the one-way full-duplex AF relay channel, whereas the sum rate of the two-way half-duplex DF relay channel achieves the rate of the one-way full-duplex DF relay channel only in certain cases.
The NICT/ATR Speech Translation System for IWSLT 2007 (2007)

This paper describes the NiCT-ATR statistical machine trans-lation (SMT) system used for the IWSLT 2007 evaluation campaign. We participated in three of the four language pair translation tasks (CE, JE, and IE). We used a phrase-based SMT system using log-linear feature models for all tracks. This year we decoded from the ASR n-best lists in the JE track and found a gain in performance. We also applied some new techniques to facilitate the use of out-of-domain external resources by model combination and also by uti-lizing a huge corpus of n-grams provided by Google Inc.. Using these resources gave mixed results that depended on the technique also the language pair however, in some cases we achieved consistently positive results. The results from model-interpolation in particular were very promising. 1.
A hybrid multimodal non-rigid registration of MR images based on diffeomorphic demons (2010)

In this paper we present a novel hybrid approach for multimodal medical image registration based on diffeomorphic demons. Diffeomorphic demons have proven to be a robust and efficient way for intensity-based image registration. A very recent extension even allows to use mutual information (MI) as a similarity measure to registration multimodal images. However, due to the intensity correspondence uncertainty existing in some anatomical parts, it is difficult for a purely intensity-based algorithm to solve the registration problem. Therefore, we propose to combine the resulting transformations from both intensity-based and landmark-based methods for multimodal non-rigid registration based on diffeomorphic demons. Several experiments on different types of MR images were conducted, for which we show that a better anatomical correspondence between the images can be obtained using the hybrid approach than using either intensity information or landmarks alone.
Method of concentration of power in materials for x-ray amplification (1992)

Recent experimental and theoretical results indicate that a new technique for the controlled concentration of power in materials may be feasible. The power levels that are potentially achievable are sufficient for the generation of amplification of x-ray wavelengths in the kilovolt range. The method of power concentration involves the combination of (1) a new ultrahigh brightness subpicosecond laser technology, (2) multiphoton coupling to atoms and molecules, and (3) a new channeled mode of electromagnetic propagation. The energy scaling of this approach is the most important consideration, and it is shown that the control of the propagation is the key factor that enables high levels of amplification in the kilovolt regime to be achieved with a total excitation energy of ~1 J.
Resolvin’ inflammation (2016)

Plaque progression was halted by inducing inflammation resolution in the blood vessel walls of a mouse model of atherosclerosis with the preresolving lipid mediator RvD1.
Pentagastrin Cytoprotection in Ethanol‐Induced Gastric Mucosal Lesions in Rats (1993)

To establish pentagastrin cytoprotection, the effectiveness of various doses of pentagastrin on ethanol induced gastric mucosal lesions was investigated in Wistar rats. Significant protection was obtained only after parenteral pretreatment with the exception of the lowest dose (1 microgram/kg b.w.). Pentagastrin cytoprotection is not mediated either by a dopamine, muscarinic or gastrin/CCK receptor or by prostaglandin synthesis. However, the protective effect of pentagastrin is abolished by prior vagotomy, although this procedure alone or sham operation is ineffective to influencing control-ethanol lesions. In secretory studies pentagastrin increased both the volume of gastric juice and total acid output. Unlike cytoprotection, these were reversed by vagotomy, but also with atropine and problumide, whereas domperidone and indomethacin were ineffective.