gebhart/patrepeval huggingface dataset:
Therapy-related acute promyelocytic leukemia (t-APL): Observations on APL pathogenesis. (2011)

6567 Background: Therapy-related acute promyelocytic leukemia (t-APL) is a well-recognized form of APL for which the underlying pathogenesis has been well defined. Most cases arise as de novo APL (dn-APL) for which epidemiologic studies have identified increased body mass index (BMI) and ethnicity as possible risk factors. We analyzed demographics, clinical features and treatment responses in a contemporary series of patients (pts) treated with ATRA and anthracycline-based induction and consolidation to assess for differences in these 2 etiologically distinct pt groups. Methods: Retrospective analysis of 64 consecutive APL pts treated from 2003 to 2010 Results: Eleven (17.2%) had t-APL due to chemotherapy and or radiation for carcinoma (n=8) or autoimmune disease (n=3). Cytogenetic analysis in these t-APL pts showed the typical t(15;17)(q22;q12) alone. Compared to pts with t-APL, those with dn-APL had a greater median BMI of 31.33 vs 28.48 and 60.4% vs 27.3% were obese (p =0.04). More dn-APL pts (45.3% vs 18.2%) had hyperlipidemia (p=0.01). Incidence of M3v at 0.9% vs 11.3% and median WBC at 0.9 vs 1.6 x 109/ L (p-0.03), was lower in t-APL while age (61 vs 56 yrs) was not statistically significantly different. Complete remission was achieved in fewer t-APL than dn-APL pts (63.6% vs 92.5%), reflecting a greater induction death (ID) rate (36.4% vs 7.5%). The incidence of DS was similar at 27.3% and 22.6%, respectively. No cases of leukemic resistance were seen in either group. Median follow up of surviving patients (n=48) is 49 m (2.5-200).The OS was lower in t-APL (45.5% vs 79.2%) primarily secondary to the higher ID rate. Relapse occurred in 16.1% overall, with none in the t-APL cohort. Conclusions: Patients with dn-APL had a significantly greater incidence of obesity and hyperlipidemia, a higher presenting WBC and more had M3v disease than those with t-APL, for whom pathogenesis is well-defined. These observations suggest that abnormalities in lipid metabolism may be of etiologic and phenotypic significance in dn-APL. The lower OS of the t-APL cohort cannot be attributed to leukemic resistance or relapse because ID mortality was the main cause of failure.
Multi-Energy Trial Operation of the HIT Medical Synchrotron: Accelerator Model and Data Supply (2017)

At the Heidelberg ion beam therapy center (HIT) cancer patients are treated with the raster-scanning dose delivery method of heavy ion pencil beams. The beams are provided by a synchrotron which allows for a variation of the ion penetration depth by changing the ion beam energy for each synchrotron cycle. In order to change the beam energy within one synchrotron cycle the accelerator model and data supply model within the control system have been extended extensively. In this first data supply model beam re-acceleration or deceleration between two arbitrary extraction energies is defined. The model defines an additional transition phase, i.e. current/set value patterns between extraction and the re-acceleration yet giving the possibility of setting the beam properties suitable for further acceleration/deceleration. This includes the dipoles, correctors, quadrupoles, sextupoles, KO-Exciter (spill break), and RF. This allowed for the survey and optimisation of the beam properties including possible beam losses of the re-accelerated, transversally blown up beam for arbitrary energy levels.
Pyrolysis ofn-Tetradecane in Free Droplet Vaporization (1984)

Abstract The pyrolysis of n-tetradecane in free droplet vaporization was studied in a laminar flow furnace. Furnace exhaust products were sampled as a function of furnace temperature, process gas flow rate, and droplet spacing. The principal pyrolysis products in a helium environment were C1-C4 hydrocarbons, polycyclic aromatic hydrocarbons (PAH) and soot. The light products were methane, ethane, ethylene, propylene, and acetylene, primarily. PAH were identified using high resolution, quartz capillary gas chromatography and high pressure liquid chromatography. A wide distribution of PAH was found, but most of the PAH contained four fused rings or less. At 600°C the droplets vaporized completely without pyrolysis. At 800°C, all the tetradecane is converted to light gases and PAH are first detected. PAH attain a maximum level near 1100°C before appreciable soot production commences. Pyrolysis product levels are also a strong function of residence time and droplet spacing; maximum PAH levels shift to higher temperature at reduced residence time, and PAH levels are increased substantially at reduced droplet spacing. A rough estimate of the overall activation energy for soot production in the range 1000-1400°C is 35 kcal/mole.
Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans (2016)

Macrophages are key players involved in numerous pathophysiological pathways and an in-depth characterization of their gene regulatory networks can help in better understanding how their dysfunction may impact on human diseases. We here conducted a cross-species network analysis of macrophage gene expression data between human and mouse to identify conserved networks across both species, and assessed whether such networks could reveal new disease-associated regulatory mechanisms. From a sample of 684 individuals processed for genome-wide macrophage gene expression profiling, we identified 27 groups of coexpressed genes (modules). Six modules were found preserved (P < 10<sup>-4</sup>) in macrophages from 86 mice of the Hybrid Mouse Diversity Panel. One of these modules was significantly [false discovery rate (FDR) = 8.9 × 10<sup>-11</sup>] enriched for genes belonging to the oxidative phosphorylation (OXPHOS) pathway. This pathway was also found significantly (FDR < 10<sup>-4</sup>) enriched in susceptibility genes for Alzheimer, Parkinson, and Huntington diseases. We further conducted an expression quantitative trait loci analysis to identify SNP that could regulate macrophage OXPHOS gene expression in humans. This analysis identified the PARK2 rs192804963 as a trans-acting variant influencing (minimal P-value = 4.3 × 10<sup>-8</sup>) the expression of most OXPHOS genes in humans. Further experimental work demonstrated that PARK2 knockdown expression was associated with increased OXPHOS gene expression in THP1 human macrophages. This work provided strong new evidence that PARK2 participates to the regulatory networks associated with oxidative phosphorylation and suggested that PARK2 genetic variations could act as a trans regulator of OXPHOS gene macrophage expression in humans.
Enveloping users and computers in a collaborative 3D augmented reality (2003)

We present EMMIE (Environment Management for Multiuser Information Environments), a prototype experimental user interface to a collaborative augmented environment. Users share a 3D virtual space and manipulate virtual objects that represent information to be discussed. We refer to EMMIE as a hybrid user interface because it combines a variety of different technologies and techniques, including virtual elements such as 3D widgets, and physical objects such as tracked displays and input devices. See-through head-worn displays overlay the virtual environment on the physical environment, visualizing the pervasive "virtual ether" within which all interaction occurs. Our prototype includes additional 2D and 3D displays, ranging from palm-sized to wall-sized, allowing the most appropriate one to be used for any task. Objects can be moved among displays (including across dimensionalities) through drag-and-drop. In analogy to 2D window managers, we describe a prototype implementation of a shared 3D environment manager that is distributed across displays, machines, and operating systems. We also discuss two methods we are exploring for handling information privacy in such an environment.
Temporal pulse compression in a xenon-filled Kagome-type hollow-core photonic crystal fiber at high average power (2011)

In this study we demonstrate the suitability of Hollow-Core Photonic Crystal Fibers (HC-PCF) for multiwatt average power pulse compression. We spectrally broadened picosecond pulses from a SESAM mode-locked thin disk laser in a xenon gas filled Kagome-type HC-PCF and compressed these pulses to below 250 fs with a hypocycloid-core fiber and 470 fs with a single cell core defect fiber. The compressed average output power of 7.2 W and 10.2 W at a pulse repetition rate of approximately 10 MHz corresponds to pulse energies of 0.7 µJ and 1 µJ and to peak powers of 1.6 MW and 1.7 MW, respectively. Further optimization of the fiber parameters should enable pulse compression to below 50 fs duration at substantially higher pulse energies.
Effects of pelvic floor muscle contraction on anal canal pressure (2006)

The role of pelvic floor muscle contraction in the genesis of anal canal pressure is not clear. Recent studies have suggested that vaginal distension increases pelvic floor muscle contraction. We studied the effects of vaginal distension on anal canal pressure in 15 nullipara asymptomatic women. Anal pressure, rest, and squeeze were measured using station pull-through manometry techniques with no vaginal probe, a 10-mm vaginal probe, and a 25-mm vaginal probe in place. Rest and squeeze vaginal pressures were significantly higher when measured with the 25-mm probe compared with the 10-mm probe, suggesting that vaginal distension enhances pelvic floor contraction. In the presence of the 25-mm vaginal probe, rest and squeeze anal pressures in the proximal part of the anal canal were significantly higher compared with no vaginal probe or the 10-mm vaginal probe. On the other hand, distal anal pressures were not affected by any of the vaginal probes. Ultrasound imaging of the pelvic floor revealed that vaginal distension increased the anterior-posterior length of the puborectalis muscle. Atropine at 15 micro g/kg had no influence on the rest and squeeze anal pressures with or without vaginal distension. Our data suggest that pelvic floor contractions increase pressures in the proximal part of the anal canal, which is anatomically surrounded by the puborectalis muscle. We propose that pelvic floor contraction plays an important role in the fecal continence mechanism by increasing anal canal pressure.
Abstract 20997: In Postoperative Conotruncal Anomalies Patients Differential Branch Pulmonary Artery Regurgitant Fraction is a Function of Differential Pulmonary Vascular Resistance and Pulmonary Arterial Properties (2010)

Introduction: Repaired conotruncal anomaly patients frequently have residual branch pulmonary artery (BPA) stenosis or size differences associated with differential BPA regurgitation. Hypothesis: I...
Effects of Influencing the Individual Leg Inductance in Case of Paralleling Modules on Basis of XHP 3 and EconoDUAL (2017)

Paralleling, not just of IGBT modules, is of special interest for customers as they can easily adapt the individual systems current rating, just by choosing the amount of devices. This trend is supported by semiconductor manufacturers through, e.g. modular IGBT module concepts, such as XHPTM 3 or EconoDUAL(exp TM). But utilization of such a system to its full extent requires not only an appropriate module design, but in addition a well-defined environment, especially an inductively uniform designed DC busbar and PCB layout, respectively. In this paper the effectiveness of an inductively non-uniform DC busbar is discussed on device level on basis of experiments as well as by means of simulations. Moreover, the impact of a demonstrative containment action has been examined by experiments.
Long-Life Polysulfide–Polyhalide Batteries with a Mediator-Ion Solid Electrolyte (2019)

Polysulfide–polybromide and polysulfide–polyiodide batteries are promising redox-flow systems due to their use of low-cost and abundant active materials. However, these systems have traditionally suffered from substantial crossover of redox active materials, causing loss of active material and the necessity of reconditioning their electrolytes, which has the overall effect of lowering battery lifetimes and adding system level costs. This work demonstrates how using a solid electrolyte instead of the traditional Nafion separator completely prevents crossover of redox active species, enabling long cycle life batteries. To achieve this, a “mediator-ion” strategy is employed, in which Li+ or Na+ ions transfer ionic charge through the solid electrolyte to achieve charge balance without active participation in the anode and cathode reactions. This is demonstrated with both polysulfide–polybromide (PSB) and polysulfide–polyiodide (PSI) batteries. The effect of the solid electrolyte on battery rate performance, as well as the long-term stability of the ceramic electrolyte in the corrosive polybromide and polyiodide catholytes, is examined.
The Determination of Modified Barrier Heights in Ti/GaN Nano-Schottky Diodes at High Temperature (2008)

We have investigated the size-effect of the nano-Schottky diodes on the electrical transport properties and the temperature-dependent current transport mechanism in a metal-semiconductor nanowire junction (a Ti/GaN nano-Schottky diode) using current-voltage characterization in the range of 300-423 K. We found that the modified mean Schottky barrier height (SBH) was approximately 0.7 eV with a standard deviation of approximately 0.14 V using a Gaussian distribution model of the barrier heights. The slightly high value of the modified mean SBH (approximately 0.11 eV) compared to the results from the thin-film based Ti/GaN Schottky diodes could be due to an additional oxide layer at the interface between the Ti and GaN nanowires. Moreover, we found that the abnormal behavior of the barrier heights and the ideality factors in a Ti/GaN nano-Schottky diode at a temperature below 423 K could be explained by a combination of the enhancement of the tunneling current and a model with a Gaussian distribution of the barrier heights.
Image based fixed time visual servoing control for the quadrotor UAV (2019)

In this study, the visual servoing control problem is investigated, and a fixed time based visual servoing control scheme is proposed for quadrotor unmanned aerial vehicles. First, based on the perspective projection principle and target points, effective image features are defined on an image plane called the virtual image plane. Then, the image feature dynamics and QUAV dynamics are combined to derive a coupled non‐linear system, and the non‐linear system is decoupled into two subsystems under inner–outer loop control framework. Furthermore, the novel sliding mode surfaces based fixed‐time controllers are designed, and the resulting closed‐loop systems are proved to be stable. Finally, the numerical simulations and experiments are conducted to validate the effectiveness of the proposed control scheme.
Obif, a Transmembrane Protein, Is Required for Bone Mineralization and Spermatogenesis in Mice (2015)

Our results, taken together with previous observations, indicate that Obif is a type Ia transmembrane protein whose N-terminal region is O-glycosylated. In addition, we found that Obif is required for normal bone mineralization and late testicular differentiation in vivo. These findings suggest that Obif plays essential roles in the development of multiple tissues.
Synthesis of Nickel Sulfide by Homogeneous Precipitation from Acidic Solutions of Thioacetamide (1996)

Nickel sulflde powders were precipitated by utilizing the thermal decomposition of thioacetamide in acidic aqueous solutions. Precipitation was induced by a direct reaction between thioacetamide and nickel at 70° and 80°C with thioacetamide concentrations of 0.80 M . Precipitation was induced by reaction of sulfide ions with nickel at 90°C and at low pH. Direct reaction products were amorphous and contained significant amounts of carbon, excess sulfur, and hydrogen. Hydrolysis‐controlled precipitation yielded faceted crystalline particles 2 to 4 μm in size. Crystalline, spherical particles with compositions near stoichiometric NiS were precipitated with high yields.
Effect of Novel Design Modifications on Fibrotic Encapsulation: An In Vivo Glaucoma Drainage Device Study in a Rabbit Model (2020)

Modified AGVs with plate coatings and AGVs with micro-patterned plates both appear to reduce postoperative fibrotic encapsulation and aqueous outflow resistance by altering the tissue response to implanted materials. Further studies are needed to characterize the safety and role of plate surface modifications on glaucoma drainage devices.
Predictors of Early Neurological Improvement in Patients with Anterior Large Vessel Occlusion and Successful Reperfusion Following Endovascular Thrombectomy—Does CT Perfusion Imaging Matter? (2022)

CTP ASPECTS might better predict ENI than non-contrast CT at baseline in patients with successful reperfusion following EVT.
Bilateral thyroid follicular compact-cellular carcinoma in a llama (2019)

An 18-y-old female llama (<i>Lama glama</i>) in Saskatoon, Saskatchewan was examined during a routine herd check, and a mass was detected in the ventral cervical area just below the angle of the jaw. No clinical signs were evident except for the mass and chronic loss of body condition. Postmortem examination revealed bilateral enlargement of the thyroid gland with multiple cysts. Histopathology of the thyroid gland revealed follicular compact-cellular carcinoma lesions, with infiltration of neoplastic thyroid follicular cells in regional lymph nodes.
ChemInform Abstract: DIE HOMOGENE KATALYTISCHE HYDRIERUNG MIT HILFE VON RHODIUM‐DIPHOSPHIN‐KOMPLEXEN (1975)

Abstract Aus dem Rhodium‐Äthylen‐Komplex (I) werden mit den Diphosphinen (II) die Rhodium‐Diphosphin‐Komplexe (III) neben (IV) gebildet.
Specific Proline and Hydroxyproline Detection Method by Post-column Derivatization for High-performance Liquid Chromatography (1995)

Journal Article Specific Proline and Hydroxyproline Detection Method by Post-column Derivatization for High-performance Liquid Chromatography Get access Akio Ozaki, Akio Ozaki Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3–6–6 Asahimachi, Machida, Tokyo 194, Japan Corresponding author. Present address: Research and Development Division, Kyowa Hakko Kogyo Co., Ltd., 1–6–1, Otemachi, Chiyoda-ku, Tokyo 100, Japan. Search for other works by this author on: Oxford Academic Google Scholar Takeshi Shibasaki, Takeshi Shibasaki Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3–6–6 Asahimachi, Machida, Tokyo 194, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideo Mori Hideo Mori Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3–6–6 Asahimachi, Machida, Tokyo 194, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 59, Issue 9, 1 January 1995, Pages 1764–1765, https://doi.org/10.1271/bbb.59.1764 Published: 01 January 1995 Article history Published: 01 January 1995 Received: 21 February 1995
Synthetic fibrous hydrogels as a platform to decipher cell–matrix mechanical interactions (2023)

Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bidirectional mechanical exchange is crucial for many cell functions, it remains poorly understood. Key challenges are that the majority of available matrices for such studies, either natural or synthetic, are difficult to control or lack biological relevance. Here, we use a synthetic, yet highly biomimetic hydrogel based on polyisocyanide (PIC) polymers to investigate the effects of the fibrous architecture and the nonlinear mechanics on cell-matrix interactions. Live-cell rheology was combined with advanced microscopy-based approaches to understand the mechanisms behind cell-induced matrix stiffening and plastic remodeling. We demonstrate how cell-mediated fiber remodeling and the propagation of fiber displacements are modulated by adjusting the biological and mechanical properties of this material. Moreover, we validate the biological relevance of our results by demonstrating that cellular tractions in PIC gels develop analogously to those in the natural ECM. This study highlights the potential of PIC gels to disentangle complex bidirectional cell-matrix interactions and to improve the design of materials for mechanobiology studies.
Exact Analysis of Three-Phase Rectifiers With Constant Voltage Loads (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this paper, an exact solution of a circuit model for a three-phase rectifier with constant-voltage load and ac-side reactance that operates in the continuous conduction mode is presented. Obtained results are compared to the results provided applying sinusoidal approximation, published previously. It is shown that the sinusoidal approximation provides acceptable results at low output voltages, with the accuracy being decreased for the output voltages approaching to the discontinuous conduction mode boundary. Computational complexity of the exact solution is about the same as for the solution obtained applying sinusoidal approximation. </para>
Planar-doped barriers in GaAs by molecular beam epitaxy (1980)

A new majority carrier rectifying device is demonstrated which is made in gallium arsenide by molecular beam epitaxy. It exhibits thermionic transport with positive and negative bias and the barrier height and degree of asymmetry in the I/V characteristic can be continuously varied. The device also shows a constant capacitance with bias.
Electrochemistry and infrared spectroelectrochemistry of MnSnPh4-n (M = CpMo(CO)3, Mn(CO)5, CpFe(CO)2; n = 1, 2) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemistry and infrared spectroelectrochemistry of MnSnPh4-n (M = CpMo(CO)3, Mn(CO)5, CpFe(CO)2; n = 1, 2)John P. Bullock, Michael C. Palazzotto, and Kent R. MannCite this: Inorg. Chem. 1990, 29, 22, 4413–4421Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ic00347a018https://doi.org/10.1021/ic00347a018research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts