gebhart/patrepeval huggingface dataset:
Development of Printed-on Quarter Glass TV Antenna (1987)

&lt;div class="htmlview paragraph"&gt;This paper describes the development of printed-on quarter glass TV antenna using the improved simulation method. This method was based on the Wire-Grid Moment Method and have been newly improved to analyze the characteristics of printed-on glass antenna with making experimental and theoretical studies on the following RF characteristics of vehicular sheet glasses; (1) Relative dielectric constant, (2) Transmissivity, (3) Wave length reduction. Using this new method, the numerical solution of basic printed-on quarter glass TV antenna characteristics was closely agreed with measurement results. So that this new method has been put to useful one in analyzing and constructing the design concept of the newly developed printed-on glass TV antenna.&lt;/div&gt;
Endophytes and Natural Medicines (2005)

With the development of research in the field of endophytes, the role of secondary metabolites of endophytes in drug discovery has been greatly enhanced in the past few years. As more and more bioactive substances have been isolated from endophytes, the natural products of endophytes show us plentiful diversity, and became an important source of new drug discovery. The recent review highlights the research development of endophytes in natural medicines discovery.
Seeing a Single Atom Where It Is Not (2018)

We demonstrate that spin-orbit coupling of light can lead to fundamental wavelength-scale errors in optical precision localization of sub-wavelength scale emitters using far-field optical imaging techniques. The effect occurs even for perfect, aberration-free imaging.
Acute viral bronchiolitis in South Africa: Strategies for management and prevention (2016)

Management of acute viral bronchiolitis is largely supportive. There is currently no proven effective therapy other than oxygen for hypoxic children. The evidence indicates that there is no routine benefit from inhaled, rapid short-acting bronchodilators, adrenaline or ipratropium bromide for children with acute viral bronchiolitis. Likewise, there is no demonstrated benefit from routine use of inhaled or oral corticosteroids, inhaled hypertonic saline nebulisation, montelukast or antibiotics. The last should be reserved for children with severe disease, when bacterial co-infection is suspected. Prevention of respiratory syncytial virus (RSV) disease remains a challenge. A specific RSV monoclonal antibody, palivizumab, administered as an intramuscular injection, is available for children at risk of severe bronchiolitis, including premature infants, young children with chronic lung disease, immunodeficiency, or haemodynamically significant congenital heart disease. Prophylaxis should be commenced at the start of the RSV season and given monthly during the season. The development of an RSV vaccine may offer a more effective alternative to prevent disease, for which the results of clinical trials are awaited. Education of parents or caregivers and healthcare workers about diagnostic and management strategies should include the following: bronchiolitis is caused by a virus; it is seasonal; it may start as an upper respiratory tract infection with low-grade fever; symptoms are cough and wheeze, often with fast breathing; antibiotics are generally not needed; and the condition is usually self limiting, although symptoms may occur for up to four weeks in some children.
Wavelength and Duration-Tunable 10-GHz 1.3-ps Pulse Source Using Dispersion Decreasing Fiber-Based Distributed Raman Amplification (2004)

We experimentally demonstrate a novel pulse compression scheme using dispersion decreasing fiber (DDF)-based distributed Raman amplification. We adiabatically compress 10-GHz 13-ps seed pulses generated using a commercially available electroabsorption modulator into high-quality 1.3-ps pulses in a 20-km DDF-based diode-pumped Raman amplifier. The usual DDF adiabatic soliton compression process is assisted by the distributed Raman gain along the fiber and by control of the input pulse chirp. Both wavelength tunability of about 30 nm and pulse-duration tunability from 1 to 5 ps are also demonstrated.
Texture Analysis of Supraspinatus Ultrasound Image for Computer Aided Diagnostic System (2016)

This algorithm will be helpful to diagnose supraspinatus tendon tear on ultrasound images.
13C Metabolic flux analysis and kinetic modeling of Clostridium thermocellum grown on cellobiose (2020)

<i>Clostridium thermocellum</i> is a promising candidate for consolidated bioprocessing due to its ability to consume and ferment cellobiose to ethanol. Despite significant efforts, achieved yields and titers fall below industrially relevant targets. This implies that enzymatic, regulatory, and possibly thermodynamic bottlenecks that throttle back metabolic flow still exist. This
Lump Solutions to the (3+1)-Dimensional Generalized B-Type Kadomtsev-Petviashvili Equation (2018)

This paper is devoted to the study of lump solutions to the (3+1)-dimensional generalized B-type Kadomtsev-Petviashvili equation. First we use a direct method to construct a class of exact solutions which contain six arbitrary real constants. Then we use these solutions to generate lump solutions with four real parameters. We also determine the amplitude and velocity of these lumps.
Photoconductive switch package configurations having a profiled resistive element (2023)

Methods, systems, and devices are disclosed for photoconductive switch package configurations. In some aspects, a photoconductive switch package includes of a wide bandgap photoconductive material (e.g., GaN, ZnO, diamond, AlN, SiC, BN, etc.), a source for energetic photons (e.g., a laser), a mechanism to couple the laser into the switch, and a mechanism for high voltage to enter and leave the switch package. In some implementations, the disclosed photoconductive switch packages can be configured as a three terminal device, e.g., similar to transistors, with one of the terminals being laser input or the voltage input to the laser system.
Pipelined Broadcast with Enhanced Wormhole Routers (2002)

This paper proposes the Pipelined Broadcast that broadcasts a message of size m in O(m+n-1) time in an n-dimensional hypercube. It is based on the replication tree, which is derived from the reachable sets. It greatly improves the performance compared to Ho-Kao s algorithm with the time of O(m[n/log(n+1)]). The communication in the broadcast uses all-port wormhole router with message replication capability. This paper includes the algorithm together with performance comparisons to previous schemes in practical implementation.
Photon‐Pen Writing for Metal Oxide‐Based Versatile Nanosensors (2022)

Abstract Low‐temperature processes and simplification of lithographic techniques are key challenges for the fabrication of solution‐processed metal oxide‐based nanodevices. Recent breakthroughs in location‐specific synthetic methodologies involving inkjet printing and photon‐activation routes have enabled lithography‐free and bottom‐up fabrication of such devices. However, a revolutionary strategy to resolve room‐temperature direct fabrication of metal oxide‐based materials still remains elusive. Here, a pertinent route enabling wafer‐scale, location‐specific direct‐writing, termed “photon‐pen writing (PPW),” of functional metal oxide‐based devices is proposed. Using PPW, fabrication of elaborate patterns of metal oxides is demonstrated through location‐specific dechlorination and subsequent oxidation via thermal energy transfer of a focused infrared laser in ambient environment. By tailoring process parameters, precise manipulation of the chemical and structural features of the PPW‐produced metal‐oxide patterns are demonstrated. The versatility of the PPW process by realizing a highly sensitive, stable, uniform, and wafer‐scale nanosensor array for gas and light detection using PPW‐ZnO channel and PPW‐ITO electrodes is demonstrated, with 4.1% of response at 50 ppb NO 2 and 2.93 ± 0.23 µ A of photocurrent for 0.76 mW cm −2 , 254 nm UV light. A new route toward wafer‐scale production of bespoke nanosensor arrays onto single chip for next‐generation nanoelectronics is introduced.
Seminal Plasma Modifies the Transcriptional Pattern of the Endometrium and Advances Embryo Development in Pigs (2019)

<b>Background:</b> Seminal plasma (SP) promotes sperm survival and fertilizing capacity, and potentially affects embryo development, presumably via specific signaling pathways to the internal female genital tract. <b>Objectives:</b> This study evaluated how heterologous SP, infused immediately before postcervical artificial insemination (AI) affected embryo development and the transcriptional pattern of the pig endometria containing embryos. <b>Materials and Methods:</b> Postweaning estrus sows (<i>n</i> = 34) received 40-mL intrauterine infusions of either heterologous pooled SP or Beltsville Thawing Solution (BTS; control) 30 min before AI of semen extended to 10% of homologous SP. Embryos (all sows) and endometrium samples (3 sows/group) were removed during laparotomy 6 days after the infusion of SP or BTS to morphologically evaluate the embryos to determine their developmental stage and to analyze the endometrial transcriptome using microarrays (PORGENE 1.0 ST GeneChip array, Affymetrix) followed by qPCR for further validation. <b>Results:</b> Embryo viability was equal between the groups (~93%), but embryo development was significantly (<i>P</i> < 0.05) more advanced in the SP-treated group compared to control. A total of 1,604 endometrium transcripts were differentially expressed in the SP group compared to the control group. An enrichment analysis showed an overrepresentation of genes and pathways associated with the immune response, cytokine signaling, cell cycle, cell adhesion, and hormone response, among others. <b>Conclusions:</b> SP infusions prior to AI positively impacted the preimplantation embryo development and altered the expression of the endometrial genes and pathways potentially involved in embryo development.
Lubricant Additives Based on Carbon Nanotubes Produced from Carbon-Rich Fly Ash (2016)

Carbon-rich fly ash has been reported to be a suitable precursor and catalyst for carbon nanotube (CNT) growth. In this work, CNTs grown from carbon-rich fly ash were evaluated as a lubricant oil additive to reduce the friction coefficient of metallic surfaces using a ball-on-disk tribometer. Different concentrations of the as-grown CNTs in the range 0.005–0.5 wt% were dispersed in a base sunflower oil. The value of the friction coefficient was also investigated as a function of load. Excellent results were obtained for the value of the friction coefficient, where it drastically decreased to around 58% of its original value without additives. This was achieved at a very low concentration of CNTs; that is, 0.1 wt%. The obtained result was compared with that of a commercial multiwalled CNT at the same concentration and found to be superior. This superiority of CNTs produced from fly ash could be attributed to the existence of active radical sites on their side wall. Moreover, the friction coefficient value was observed to decrease with increasing load, which might be due to the formation of protective graphitic carbon layers on antagonist surfaces. The viscosity of pure and 0.1 wt% CNTs-impregnated base oil was also studied in the 25–100°C temperature range. No significant changes are observed in the viscosity of the CNTs-impregnated base oil. These results suggest that the low-cost CNTs produced from fly ash are excellent nanomaterials as additives for lubricant oil.
A phase I study of RX-3117, an oral agent activated by uridine cytidine kinase 2, to treat subjects with advanced solid tumors. (2015)

TPS2605 Background: RX-3117 is an oral small-molecule antimetabolite, cyclopentyl pyrimidyl nucleoside that is activated by uridine cytidine kinase 2. RX-3117’s efficacy in xenograft models (Colo-205, H460, H69 and CaSki), which are moderately sensitive or resistant to gemcitabine, indicates that RX-3117 may have the potential to treat tumors that do not respond to gemcitabine or have become gemcitabine resistant. Methods: This phase I, open-label, multicenter study evaluates the efficacy and safety of RX-3117 in subjects with solid tumors). RX-3117 is administered 3 times a week for 3 weeks with 1 week off during each 4 week cycle. Dose escalation starts with an accelerated design treating 1 subject per dose followed by a standard 3 + 3 design using a modified Fibonacci sequence after the occurrence of a single related Grade 2 or greater adverse event. The primary endpoint is the overall safety profile characterized by the type, frequency, severity, timing of onset, duration and relationship to study therapy of any adverse events, or abnormalities of laboratory tests or electrocardiograms, any dose limiting toxicities that occur during Cycle 1, serious adverse events, or adverse events leading to study treatment discontinuation. Secondary endpoints include pharmacokinetic parameters (e.g., time to maximum observed concentration [Tmax], maximum observed plasma concentration [Cmax], trough concentration [Ctrough], area under the concentration-time curve [AUC]) and Indices of anti-tumor activity (e.g., overall response rate , time to response, duration of response, and progression-free survival). Exploratory endpoints are baseline biomarker expression/concentration, including (but not limited to) concentrative nucleoside transporter 2; equilibrative nucleoside transporter 1; uridine-cytidine kinase 1 and 2; DNA methyltransferase 1, 3a and 3b; and ribonucleotide reductases 1 and 2. Target recruitment is approximately 30 subjects. Eligible subjects must have confirmed histologic or cytologic evidence of metastatic or locally advanced solid neoplasm that has failed to respond to standard therapy, progressed despite standard therapy or for which standard therapy does not exist. Clinical trial information: NCT02030067.
Hydrogen-Bonding in Cardo Copoly(aryl ether ketone)s and Its Effects on the Gas Permeation Behavior (2007)

A series of hydrogen-bonded cardo poly(aryl ether ketone) copolymers were prepared by polymerization from a mixture of phenolphthalein (PPH) and 3,3‘-bis(4-hydroxyphenyl)isobenzopyrrolidone (HPP) with equivalent molar bis(4-nitrophenyl) ketone. The gas permeabilities of H2, O2, and N2 through copolymer membranes were examined over a temperature range of 30−100 °C. In comparison with bisphenol A polysulfone (PSF), all the homo- and copolymers exhibited similar H2 permeability coefficients, but H2/N2 selectivity coefficients were more than twice as high as that of PSF. Of interest was the observation that, different from previous other copolymers, the gas permeability in this study exhibited a sigmoid dependency on comonomer composition, and the variation amplitude of gas permeability coefficients between wave trough (40 mol % HPP) and wave crest (60 mol % HPP) was reduced with increased temperature. This peculiar phenomenon was interpreted according to polymeric structural factors, including free volume, interchain distance, glass transition, secondary transition, and the effect of temperature on interchain hydrogen bonds.
Mapping of Functional Subdomains in the Terminal Protein Domain of Hepatitis B Virus Polymerase (2016)

HBV is a major cause of viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. One important feature of this virus is its polymerase, the enzyme used to create the DNA genome from a specific viral RNA by reverse transcription. One region of this polymerase, the TP domain, is required for association with the viral RNA and production of the DNA genome. Targeting the TP domain for antiviral development is difficult due to the lack of homology to other proteins and high-resolution structure. This study mapped the TP functions according to predicted secondary structure, where it folds into alpha helices or unstructured loops. Three predicted loops were found to be the most important regions functionally and the most conserved evolutionarily. Identification of these functional subdomains in TP will facilitate its targeting for antiviral development.
Risk alleles for IgA nephropathy-associated SNPs conferred completely opposite effects to idiopathic membranous nephropathy in Chinese Han (2017)

The coexistence of immunoglobulin A nephropathy (IgAN) and idiopathic membranous nephropathy (IMN) in a few cases suggested that there could be existed a similar mechanism in pathogenesis of these two types of primary glomerulonephritis. In order to verify this hypothesis, a total of 23 reported IgAN-associated SNPs were genotyped in a cohort of 485 IMN patients and 569 healthy controls with Chinese Han origin. After Cochran-Armitage test for trend analysis, seven IgAN-associated SNPs located in the major histocompatibility complex (MHC) region were found to be significantly associated with the susceptibility of IMN, with rs9275596 as the top one (p = 1.97E-43, OR = 3.977). It was worth mentioning that the minor alleles of the SNPs conferred completely opposite effects on the pathogenesis of IMN and IgAN, suggesting quite different roles played by these SNPs for these two kinds of primary glomerulonephritis. Conditional logistic regression analysis displayed that SNPs protective from IMN (odds ratio < 1.00) were still significantly associated with IMN (p = 3.67E-4 for rs660895 and p = 1.26E-4 for rs9275224) with the most significant SNP rs9275596 as a covariate. Haplotype-based analysis showed that the seven SNPs were mapped to independent linkage disequilibrium (LD) blocks. Moreover, three out of these seven SNPs, including rs9275224, rs660895, and rs9357155, were found to be potential expression quantitative trait loci (eQTLs) for HLA-DQ molecules. Out of the purpose of identifying the causal variants for IMN within the MHC region, imputation analysis was performed using genotype data of Chinese Han released by the 1000 Genome Project and identified hundreds of SNPs potentially associated with the disease. In brief, our analysis revealed a significant association with the susceptibility of idiopathic membranous nephropathy for the IgAN-correlated SNPs. These SNPs conferred a completely different role for the pathogenesis of these two kinds of diseases.
A phase II study of concurrent WOKVAC vaccination with neoadjuvant chemotherapy and HER2-targeted monoclonal antibody therapy. (2023)

TPS636 Background: HER2+ breast cancer (BCa) is an aggressive breast cancer subtype. The treatment of Stage I-III HER2+ BCa with neoadjuvant chemotherapy and HER2 monoclonal antibodies (trastuzumab and pertuzumab) induces a pathologic complete response in 43-67% of patients. Residual HER2+ disease (i.e. residual cancer burden) after neoadjuvant therapy is associated with a significantly higher risk of recurrence. Evidence supports that HER2 immunity is progressively lost in HER2 oncogenesis and that restoration of HER2 specific CD4+ Th1 immunity is associated with a lower risk of recurrence. Trastuzumab can partially restore HER2 specific immunity, but only in a minority of patients. We have demonstrated that HER2 specific vaccination can augment HER2 specific immunity. While taxane chemotherapy can deplete immunosuppressive cells (MDSCs) 13 – 17 days after treatment creating an optimal time for vaccination. The WOKVAC vaccine is a plasmid vaccine encoding Th1 selective epitopes from HER2 and two other high-risk cancer antigens IGFBP-2 and IGF-1R. The Phase I trial of this vaccine reported that it is safe and all doses induced antigen specific Type I immune responses. We hypothesize that addition of WOKVAC to neoadjuvant chemo/HER2 targeted therapy will induce a significant increase in the number of patients with Th1 CD4+ and CD8+ T cells after neoadjuvant vaccine/chemo/HER2 therapy. Methods: Trial Design: Phase II single arm trial of WOKVAC vaccination with concurrent neoadjuvant taxane based chemotherapy, trastuzumab, and pertuzumab in patients with Stage I-III HER2+ (HR+/-) breast cancer. Enrolled patients will receive WOKVAC vaccine 150mcg on day 13 of cycles 1-3. WOKVAC vaccination may be given with either TCHP or THP. A maximum of 16 patients will be enrolled in this study. Objectives: The primary objective is to evaluate whether concurrent WOKVAC vaccine with chemotherapy and HER2 antibody therapy can significantly increase T-bet+ CD4+ and CD8+ TIL. Secondary objectives are to determine: (1) whether concurrent WOKVAC with neoadjuvant chemo/HER2 therapy is safe, (2) if the magnitude of vaccine induced antigen specific Th1 immunity after neoadjuvant therapy is associated with pathologic response. Statistical Methods: (1) In order to detect a 30% increase in the number of patients with Tbet+ CD4+ and CD8+ TIL in the enrolled patients with 80% power and a one-side alpha of 0.05, our enrollment goal for this study will be 16 patients. (2) Safety will be assessed per CTCAE v5.0, Benchmarks for safety needed to advance this trial concept to a Phase III study will be a grade 3 toxicity rate of ≤13% and a grade 4 toxicity rate of ≤ 7%. (3) The induction of Th1 immunity will be compared against the presence or absence of a complete pathologic response to determine if there is a significant correlation using Pearson r correlation analysis. Targeted Accrual: The study will accrue up to 16 patients. Clinical trial information: NCT04329065 .
A Simulation Based Approach to Automate Event Tree Generation for Early Complex System Designs (2013)

The Functional Failure Identification and Propagation (FFIP) risk assessment method has been proposed in past research for the evaluation of early system designs. Extensions of the method have been proposed in prior work to assess a set of system designs, in which there are several alternatives for component parameter values or for the configuration of components and software algorithms. A disadvantage of the method is that a single critical event scenario must be used at a time and that the simulation results must be processed manually. In this paper, an event tree-based methodology is proposed. An event tree is used to investigate the outcome of an initiating failure event when some or all of the system’s safety functions fail to activate; each branch of the tree corresponds to a specific sequence of safety functions which have failed. In this paper, a FFIP run is automatically generated for each branch of the event tree. The method determines the consequences on the system for each branch of the tree in terms of the functional failure output of the FFIP method. In addition, a software tool has been developed to support the methodology and to assist the user to investigate the consequences of each scenario that corresponds to a branch of the event tree. The methodology is illustrated with a case study from boiling water nuclear reactor design.
Supplementary Data from Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis (2023)

Supplementary Data from Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis