gebhart/patrepeval huggingface dataset:
Characteristic anticodon sequences of major tRNA species from an extreme thermophile, Thermus thermophilus HB8 (1986)

Major species of tRNA Glu , tRNA Lys , tRNA Val , tRNA Ala , tRNA Ser and tRNA Arg were purified from Thermus thermophilus HB8, and their anticodon sequences were found to be CUC, CUU, CAC, GGC, GGA and CCG, respectively, with unmodified G or C as the first letter. These anticodons exactly correspond to the codons as used most frequently among synonymous codons in the structural genes of extreme thermophiles. The stable complexes of these anticodons (in particular, GGN or CCN) with their corresponding codons probably contribute to the correct protein biosynthesis in extreme thermophiles at high temperature.
Parameter estimation for linear dynamical systems (1996)

Linear systems have been used extensively in engineering to model and control the behavior of dynamical systems. In this note, we present the Expectation Maximization (EM) algorithm for estimating the parameters of linear systems (Shumway and Stoffer, 1982). We also point out the relationship between linear dynamical systems, factor analysis, and hidden Markov models. Introduction The goal of this note is to introduce the EM algorithm for estimating the parameters of linear dynamical systems (LDS). Such linear systems can be used both for supervised and unsupervised modeling of time series. We first describe the model and then briefly point out its relation to factor analysis and other data modeling techniques. The Model Linear time-invariant dynamical systems, also known as linear Gaussian state-space models, can be described by the following two equations: x t+1 = Ax t +w t (1) y t = Cx t + v t : (2) Time is indexed by the discrete index t. The output y t is a linear function of ...
Estimation with a helper who knows the interference (2012)

We consider the problem of estimating a signal corrupted by independent interference with the assistance of a cost-constrained helper who knows the interference causally or noncausally. When the interference is known causally, we characterize the minimum distortion incurred in estimating the desired signal. In the noncausal case, we present a general achievable scheme for discrete memoryless systems and novel lower bounds on the distortion for the binary and Gaussian settings. Our Gaussian setting coincides with that of assisted interference suppression introduced by Grover and Sahai. Our lower bound for this setting is based on the relation recently established by Verdú between divergence and minimum mean squared error. We illustrate with a few examples that this lower bound can improve on those previously developed. Our bounds also allow us to characterize the optimal distortion in several interesting regimes. Moreover, we show that causal and noncausal estimation are not equivalent for this problem. Finally, we consider the case where the desired signal is also available at the helper. We develop new lower bounds for this setting that improve on those previously developed, and characterize the optimal distortion up to a constant multiplicative factor for some regimes of interest.
Performance evaluation of heuristic techniques for coverage optimization in femtocells (2011)

Self-optimization of coverage is an essential element for successful deployment of enterprise femtocells. This paper evaluates the performance of genetic algorithm, particle swarm and simulated annealing heuristic techniques to solve a multi-objective coverage optimization problem when a number of femtocells are deployed to jointly provide indoor coverage. This paper demonstrates the different behaviors of the proposed algorithms. The results show that genetic algorithm and particle swarm have a higher potential of solving the problem compared to simulated annealing. This is due to their faster convergence time which is an important parameter for dynamic update of femtocells.
Ueber den Halbaldehyd der Malonsäure (1900)

Die Ausbente betragt iiach dern Waschen und Trocknen 0.55 g, entsprerhend rund 40 pCt.der Theorie; dabei sind iiiir 3 Atome Natriurn auf 1 Xvlolektil der Nitrosaverhindung vex wcndet worden, denn eine Versurhsreihe zeigte, dass sowohl eine wesentliche Verrnehrung wie Verringcrung der Natriurnrnenge die Aosbeute herabsetzt.Die Suhstana ist als Formylderivat noch saurer Natur
Inhibitory Activity for Chitin Synthase II from Saccharomyces cerevisiae by Tannins and Related Compounds (2002)

In the course of search for potent inhibitors of chitin synthase II from natural resources, seven tannins and related compounds were isolated from the aerial part of Euphorbia pekinensis and identified as gallic acid, methyl gallate, 3-O-galloyl-(-)-shikimic acid, corilagin, geraniin, quercetin-3-O-(2″-O-galloyl)-β-D-glucoside, and kaempferol-3-O(2″-O-galloyl)-β-D-glucoside. These and nine related compounds, (-)-quinic acid, (-)-shikimic acid, ellagic acid, kaempferol, quercetin, quercitrin, rutin, quercetin-3-O-(2″-O-galloyl)-β-D-rutinoside and 1,3,4,6-tetra-O-galloyl-β-D-glucose, were evaluated for the inhibitory activity against chitin synthase II and III. They inhibited chitin synthase II with IC50 values of 18-206 μM, except for two organic acids, (-)-quinic acid and (-)-shikimic acid. Among them, 3-O-galloyl-(-)-shikimic acid was the most potent inhibitor against chitin synthase II of Saccharomyces cerevisiae with an IC50 value of 18 μM. The inhibition appears to be selective for chitin synthase II, as they did not appreciably inhibit chitin synthase III.
Hard X-ray Imaging Microscopy using X-ray Guide Tube as Beam Condenser for Field Illumination (2013)

An optical system for illumination of object in x-ray imaging microscopy is developed. The optical system is a beam condenser consisting of a single-bounce conical-shape mono-capillary (x-ray guide tube: XGT) made of Pyrex glass. The XGT condenser was tested at the beam line 47XU of SPring-8 using a Fresnel zone plate as an objective lens. Comparing with the microscope without beam condenser, the flux density is improved by a factor of 12–20 in the x-ray energy range of 6–8 keV. Test patterns with a 50 nm-structure are clearly resolved at 8 keV with an exposure time less than 1 s.
Power analog to digital converter for voltage scaling applications (2010)

In order to optimize energy efficiency, some applications require adapting supply voltage according to the work load requirements. For example, in high performance digital systems and in RF systems, voltage scaling and modulation techniques have been adopted in order to achieve a more efficient processing of the energy. These techniques are based in rapidly adjusting the system supply voltage level. In order to achieve this, a topology which is capable of achieving very fast changes of the output voltage is needed. In this paper a PWM multiphase topology whose phases are coupled by using transformers is proposed to be used in an envelope elimination and restoration (EER) technique. The proposed topology can achieve very fast changes between discrete voltage steps so it can be considered as a power analog to digital converter.
Approaching resistance to ibrutinib in diffuse large B-cell lymphoma (2016)

"Approaching resistance to ibrutinib in diffuse large B-cell lymphoma." Leukemia & Lymphoma, 57(6), pp. 1254–1255
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors. (2000)

Small round cell tumors of childhood can be histologically ambiguous, can require tumor markers for an accurate diagnosis, and include neuroblastoma, peripheral primitive neuroectodermal tumor (pPNET), Ewing's sarcoma (ES), lymphoma, and rhabdomyosarcoma. Because the cell type of origin for ES remains controversial, characterizing gene expression in ES can provide diagnostic markers and lead to better understanding of tumor biology. We studied RNA expression of the neuronal genes protein gene product 9.5 (PGP 9.5) and tyrosine hydroxylase (TH) by Northern analysis in cell lines and tissue from small round cell tumors. PGP 9.5 showed strong expression in 17 of 17 neuroblastoma cell lines, 9 of 9 pPNET cell lines, and 11 of 11 ES cell lines. PGP 9.5 was weakly expressed in 1 of 1 alveolar rhabdomyosarcoma cell lines but not in 1 of 1 embryonal rhabdomyosarcomas, and weak expression was seen in 1 of 7 leukemia cell lines. In tumor tissue, all 12 neuroblastomas expressed PGP 9.5, as did all 7 pPNET and all 7 ES. PGP 9.5 was very weakly expressed in 6 of 9 rhabdomyosarcomas and 1 of 9 lymphomas. TH was expressed only in neuroblastomas, and no TH expression was seen in cell lines or tissue from other tumors. As high expression of PGP 9.5 was only found in neural tumors; PGP 9.5 expression by ES provides further evidence for a neural origin of this tumor, whereas TH expression is highly specific for neuroblastomas. PGP 9.5 expression should allow sensitive detection of minimal residual disease for ES and pPNET using reverse transcription-PCR, and the variability in TH and PGP 9.5 expression levels in neuroblastomas indicates that expression of both genes should be used for monitoring minimal residual disease by reverse transcription-PCR.
Proximate, Mineral Composition and Sensory Acceptability of Home Made Noodles from Stinging Nettle ( Urtica simensis ) Leaves and Wheat Flour Blends (2016)

The objective of this study was to assess the effect of blending proportion of dried nettle (Urtica simensis) leaves flour on the proximate composition, mineral contents (Fe, Ca and Zn) and sensory qualities of wheat based noodles. Standard methods were used to analyze the proximate composition and mineral contents of sample noodles. Five point hedonic scales were used for sensory acceptability test of the noodles using 15 panelists with duplicate. Protein, ash, fiber, Ca, Fe and Zn contents of nettle supplemented noodles were significantly (p < 0.05) higher than that of wheat noodles (control). The sensory acceptability test revealed that, nettle supplemented (5-15%) noodles were accepted above the average in all sensory attributes, but the highest acceptability was exhibited in wheat noodles (control). Nutritious and acceptable noodle can be prepared by supplementing wheat with dried nettle (Urtica simensis) leaves flour up to 15%w/w.
Steady-state exhumation of the European Alps (2001)

Research Article| January 01, 2001 Steady-state exhumation of the European Alps Matthias Bernet; Matthias Bernet 1Department of Geology and Geophysics, Yale University, New Haven, Connecticut 06520-8109, USA Search for other works by this author on: GSW Google Scholar Massimiliano Zattin; Massimiliano Zattin 2Dipartimento di Scienze della Terra e Geologico-Ambientali, Università di Bologna, I-40127, Bologna, Italy Search for other works by this author on: GSW Google Scholar John I. Garver; John I. Garver 3Geology Department, Olin Building, Union College, Schenectady, New York 12308-2311, USA Search for other works by this author on: GSW Google Scholar Mark T. Brandon; Mark T. Brandon 4Department of Geology and Geophysics, Yale University, New Haven, Connecticut 06520-8109, USA Search for other works by this author on: GSW Google Scholar Joseph A. Vance Joseph A. Vance 5Department of Geological Sciences, University of Washington, Seattle, Washington 98195-1310, USA Search for other works by this author on: GSW Google Scholar Geology (2001) 29 (1): 35–38. https://doi.org/10.1130/0091-7613(2001)029<0035:SSEOTE>2.0.CO;2 Article history received: 16 Jun 2000 rev-recd: 09 Oct 2000 accepted: 09 Oct 2000 first online: 02 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share MailTo Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation Matthias Bernet, Massimiliano Zattin, John I. Garver, Mark T. Brandon, Joseph A. Vance; Steady-state exhumation of the European Alps. Geology 2001;; 29 (1): 35–38. doi: https://doi.org/10.1130/0091-7613(2001)029<0035:SSEOTE>2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract Fission-track grain-age distributions for detrital zircon are used in this study to resolve the late Cenozoic exhumation history of the European Alps. Grain-age distributions were determined for six sandstone samples and one modern river sediment sample, providing a record from 15 Ma to present. All samples can be traced to sources in the Western and Central Alps. The grain-age distributions are dominated by two components, P1 (8–25 Ma) and P2 (16–35 Ma), both of which show steady lag times (cooling age minus depositional age), with an average of 7.9 m.y. for P1 and 16.7 m.y. for P2. These results indicate steady-state exhumation in the source region at rates of ∼0.4–0.7 km/m.y. since at least 15 Ma. You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Generic method for 2D image resizing with non-separable filters (2005)

2D image resizing is an important issue for pixel oriented displays with variable input formats. Low-resolution pictures look bad on high-resolution screens, especially when only simple up-conversion methods like pixel and line repetition or bi-linear interpolation are used. Even when applying separable polyphase up-conversion filters, the problem of jagged lines (staircases) remains. The approach investigated for high-quality resizing by rational factors is based on pixel and line repetition with suitable post-filtering. The novel resizing method uses very simple, non-separable filters, and is suitable for all kinds of image and video material such as analog sources (PAL, NTSC), digital sources (JPEG, MPEG), low-resolution up to high-resolution images, and noisy pictures. Jagged lines can be smoothened perfectly.
A signal interpolated timing recovery system with frequency offset detector (2003)

A method of frequency offset detection for signal interpolated timing recovery is proposed. The frequency offset is estimated by measuring the correlation between the preamble and the reference sinusoid. When the frequency offset exists, the phase error changes linearly. The offset can be estimated by the gradient of the phase errors. The simulation results show that the method significantly improves the stability of the timing recovery and increases the capture range. It also decreases the preamble length and results in higher format efficiency.
The French multicentre study of ramipril in ambulatory patients with mild-to-moderate hypertension. (1992)

The aim of this 16-week trial was to determine the safety and efficacy of a step-care regimen of ramipril, an angiotensin converting enzyme inhibitor, from the minimal active dose (2.5 mg) in patients treated for mild to moderate hypertension. The trial was conducted by 102 general practitioners in 770 patients with mild to moderate hypertension. After a response rate to a 4-week placebo therapy of 9.1%, 57.0% of patients given active treatment with ramipril responded to daily doses of 2.5 mg. Ramipril 5 mg daily was effective in 55.6% of the remaining patients. There was no apparent statistically significant difference between the treatments with ramipril 10 mg or a combination of ramipril 5 mg + Lasix 20 mg daily (44.7% and 47.4% response respectively) in a 6-week double-blind arm of the study. In total, more than 90% of patients responded to treatment with ramipril by the end of the study. The incidence of adverse events was generally low, such as headache, cough, dizziness, asthenia, cramps and nausea. The incidence of cough appeared to be related both to the dosage of ramipril given and to outbreaks of influenza syndrome. Thirty-eight patients discontinued active treatment as a result of minor events such as cough, dizziness or diarrhoea, and one case each of myalgia and papular rash. There were no significant variations in laboratory parameters during the study, especially fasting blood glucose and apolipoprotein A1 and B. The results of this study provide evidence of the safety and efficacy.(ABSTRACT TRUNCATED AT 250 WORDS)
Cloning, nucleotide sequence, and engineered expression of Thermus thermophilus DNA ligase, a homolog of Escherichia coli DNA ligase (1991)

We have cloned and sequenced the gene for DNA ligase from Thermus thermophilus. A comparison of this sequence and those of other ligases reveals significant homology only with that of Escherichia coli. The overall amino acid composition of the thermophilic ligase and the pattern of amino acid substitutions between the two proteins are consistent with compositional biases in other thermophilic enzymes. We have engineered the expression of the T. thermophilus gene in Escherichia coli, and we show that E. coli proteins may be substantially removed from the thermostable ligase by a simple heat precipitation step.
Synthesis, antibacterial and antiproliferative potential of some new 1-pyridinecarbonyl-4-substituted thiosemicarbazide derivatives (2016)

In this study, the antibacterial, cytotoxic and antiproliferative activities of novel thiosemicarbazide derivatives were assessed. Our results demonstrated that some of the novel compounds possess good antibacterial properties against <i>Staphylococcus epidermidis</i>, <i>Streptococcus mutans</i> and <i>Streptococcus</i><i>sanguinis</i> and are only slightly cytotoxic; thus, they exhibit an excellent therapeutic index, which is higher than that of ethacridine lactate. Moreover, our data showed that compounds <b>2</b> and <b>4</b> have an antiproliferative activity against human breast adenocarcinoma and human hepatocellular carcinoma cell lines. We expect that the novel thiosemicarbazide derivatives can be used as agents for treatment of dental caries and also for chemotherapy support.
Improving and Scaling Trans-dimensional Random Field Language Models. (2016)

The dominant language models (LMs) such as n-gram and neural network (NN) models represent sentence probabilities in terms of conditionals. In contrast, a new trans-dimensional random field (TRF) LM has been recently introduced to show superior performances, where the whole sentence is modeled as a random field. In this paper, we further develop the TDF LMs with two technical improvements, which are a new method of exploiting Hessian information in parameter optimization to further enhance the convergence of the training algorithm and an enabling method for training the TRF LMs on large corpus which may contain rare very long sentences. Experiments show that the TRF LMs can scale to using training data of up to 32 million words, consistently achieve 10% relative perplexity reductions over 5-gram LMs, and perform as good as NN LMs but with much faster speed in calculating sentence probabilities.
Supplementary Data 1 from Integrating Global Gene Expression and Radiation Survival Parameters across the 60 Cell Lines of the National Cancer Institute Anticancer Drug Screen (2023)

Supplementary Data 1 from Integrating Global Gene Expression and Radiation Survival Parameters across the 60 Cell Lines of the National Cancer Institute Anticancer Drug Screen
Natural and Synthetic Intelligent Self-healing and Adaptive Materials for Medical and Engineering Applications (2022)

DuringAdaptive materials the last two decades, self-healingSelf-healing materials have been attracting increasing interest in both engineering and medical applications. Numerous attempts have been presented focusing on the development of different self-healingSelf-healing systems in both natural and synthetic materials with several new production and synthesis methods and self-repairSelf-repair mechanisms. The current review aims to present some of the most important natural self-healingSelf-healing materials and systems from human hard tissuesHard tissue to marine structures and animal tissue and organ regeneration that can heal or regrow their tissues and parts of their bodies. These are presented in different sections, which include, hard tissueHard tissue generation and fracture repairFracture repair, animal tissue generation and organ repair, marine structures, self-repairing coatingsCoatings for metallic alloys, concrete, hydrogelsHydrogels and polymers just to show the different approaches in this new and fascinating field of self-repairSelf-repair mechanism. Emphasis is given on the areas of tissue engineeringTissue Engineering, drug deliveryDrug delivery, medical materials and devices and implant applications.
Whole Blood Aggregation Using Impedance and Particle Counter Methods (1989)

Platelet function in platelet-rich plasma may be evaluated using an optical or electrical impedance method. Platelet function in whole blood may be studied using an impedance or particle counter method. A comparison of these techniques in whole blood has not been performed. Twenty-four healthy subjects were studied using both techniques over a range of concentrations of collagen and adenosine diphosphate (ADP). Although broad similarities exist, discordant patterns occur in individual subjects. The particle counter method is capable of detecting small aggregates and thus is more sensitive. The impedance aggregometer detects only larger aggregate formation. These techniques are complementary rather than competitive and may have considerable potential in profiling platelet function.
ABSTRACT 389 (2014)

Background and aims: During aerosol therapy with high flow nasal cannula (HFNC), drug is administered by mask with or without HFNC in place. Aims: To compare aerosol delivery via mask with and without HFNC in place using pMDI and jet nebulizer (JN) or with mesh nebulizers (MN) through HFNC. Methods: HFNC (Fisher&Paykel) at 3 lpm oxygen was administered to a 9 month airway model with a collecting filter at trachea attached to a breath simulator (Vt:100 mL, RR:30 bpm). Albuterol sulfate (2.5 mg/3 mL) was administered either with JN (Misty-neb) powered by air at 8 l/min using pediatric facemask or with MN (AeronebSolo) placed at the inspiratory inlet of a heated humidifier (Fisher&Paykel) with temperature at 37°C. Four actuations of Ventolin HFA pMDI (90 μg/puff) were administered via valved holding chamber with mask (AeroChamber-Flow-Vu). Aerosol was administered through HFNC via MN or indirectly via mask (with and without the HFNC in the nares) using pMDI or JN (n=3). Drug was eluted from the filter and quantified via spectrophotometry. Results:Table shows mass and % of albuterol dose (mean±SD) deposited distal to the trachea. Removing HFNC from the nares before aerosol treatment increased drug delivery with JN and pMDI (p <0.5) via mask, but was less than MN via HFNC (p<0.01).Table: No title available.Conclusions: During HFNC therapy, aerosol via HFNC delivered more drug than mask with or without HFNC in place.