gebhart/patrepeval huggingface dataset:
Improvement of printability by the new designe of the multi-layered coating structure (II) : The effect of pigment blending in pre-coating layer on characteristics of top-coating layer (2016)

This study was carried out in order to investigate the effect of pigment properties in a pre-coating layer on the characteristics of a top-coating layer and the print mottle of the coated paper. Five different pigments were applied for this study as raw materials for the pre-coating layer. The properties and print mottle of the coated paper samples were evaluated according to the coating color formulation. Type of pigments appliied in a pre-coating layer was one of the most important factor to control the properties of pre and top coating layer. Surface properties of pre and top coated paper were improved by blending GCC which had smaller particle size, with clay. Properties of a top-coating layer was affected by the pigment properties used in the pre-coating layer. It was found that print mottle of coated paper can be improved by replacing part of GCC with smaller particle size GCC or clay in pre-coating layer.
microRNAs in Vertebrate Physiology and Human Disease (2007)

Over the past five years, the importance of a diverse class of 18-24 nucleotide RNA molecules, known as microRNAs (miRNAs) has increasingly been recognized. These highly conserved RNAs regulate the stability and translational efficiency of complementary target messenger RNAs. The human genome is now predicted to encode nearly 1,000 miRNAs that likely regulate at least one third of all human transcripts. Despite rapid progress in miRNA discovery, the physiologic functions of only a small number have been definitively established. In this review, we discuss the principles of miRNA function that have emerged from the studies performed thus far in vertebrates. We also discuss known and potential roles for miRNAs in human disease states and discuss the influence of human genetic variation on miRNA-mediated regulation.
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation (2017)

Biological radiation dose can be estimated from dicentric chromosome frequencies in metaphase cells. Performing these cytogenetic dicentric chromosome assays is traditionally a manual, labor-intensive process not well suited to handle the volume of samples which may require examination in the wake of a mass casualty event. Automated Dicentric Chromosome Identifier and Dose Estimator (ADCI) software automates this process by examining sets of metaphase images using machine learning-based image processing techniques. The software selects appropriate images for analysis by removing unsuitable images, classifies each object as either a centromere-containing chromosome or non-chromosome, further distinguishes chromosomes as monocentric chromosomes (MCs) or dicentric chromosomes (DCs), determines DC frequency within a sample, and estimates biological radiation dose by comparing sample DC frequency with calibration curves computed using calibration samples. This protocol describes the usage of ADCI software. Typically, both calibration (known dose) and test (unknown dose) sets of metaphase images are imported to perform accurate dose estimation. Optimal images for analysis can be found automatically using preset image filters or can also be filtered through manual inspection. The software processes images within each sample and DC frequencies are computed at different levels of stringency for calling DCs, using a machine learning approach. Linear-quadratic calibration curves are generated based on DC frequencies in calibration samples exposed to known physical doses. Doses of test samples exposed to uncertain radiation levels are estimated from their DC frequencies using these calibration curves. Reports can be generated upon request and provide summary of results of one or more samples, of one or more calibration curves, or of dose estimation.
Data from Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data (2023)

&lt;div&gt;Abstract&lt;p&gt;The usefulness of mechanistic models to disentangle complex multiscale cancer processes, such as treatment response, has been widely acknowledged. However, a major barrier for multiscale models to predict treatment outcomes in individual patients lies in their initialization and parametrization, which needs to reflect individual cancer characteristics accurately. In this study, we use multitype measurements acquired routinely on a single breast tumor, including histopathology, MRI, and molecular profiling, to personalize parts of a complex multiscale model of breast cancer treated with chemotherapeutic and antiangiogenic agents. The model accounts for drug pharmacokinetics and pharmacodynamics. We developed an open-source computer program that simulates cross-sections of tumors under 12-week therapy regimens and used it to individually reproduce and elucidate treatment outcomes of 4 patients. Two of the tumors did not respond to therapy, and model simulations were used to suggest alternative regimens with improved outcomes dependent on the tumor's individual characteristics. It was determined that more frequent and lower doses of chemotherapy reduce tumor burden in a low proliferative tumor while lower doses of antiangiogenic agents improve drug penetration in a poorly perfused tumor. Furthermore, using this model, we were able to correctly predict the outcome in another patient after 12 weeks of treatment. In summary, our model bridges multitype clinical data to shed light on individual treatment outcomes.&lt;/p&gt;Significance:&lt;p&gt;Mathematical modeling is used to validate possible mechanisms of tumor growth, resistance, and treatment outcome.&lt;/p&gt;&lt;/div&gt;
Design of a Monomeric 23-Residue Polypeptide with Defined Tertiary Structure (1996)

Small proteins or protein domains generally require disulfide bridges or metal sites for their stabilization. Here it is shown that the beta beta alpha architecture of zinc fingers can be reproduced in a 23-residue polypeptide in the absence of metal ions. The sequence was obtained through an iterative design process. A key feature of the final design is the incorporation of a type II' beta turn to aid in beta-hairpin formation. Nuclear magnetic resonance analysis reveals that the alpha helix and beta hairpin are held together by a defined hydrophobic core. The availability of this structural template has implications for the development of functional polypeptides.
기계적 활성화된 분말로부터 고주파유도 가열 연소합성에 의한 나노구조 Mg_2SiO_4-MgAl_2O_4 복합재료 제조 및 기계적 특성 (2011)

Nanopowders of MgO, Al2O3 and SiO2 were made by high energy ball milling. The rapid sintering of nanostructured MgAl2O4-Mg2SiO4 composites was investigated by a high-frequency induction heating sintering process. The advantage of this process is that it allows very quick densification to near theoretical density and inhibition of grain growth. Nanocrystalline materials have received much attention as advanced engineering materials with improved physical and mechanical properties. As nanomaterials possess high strength, high hardness, excellent ductility and toughness, undoubtedly, more attention has been paid for the application of nanomaterials. Highly dense nanostructured MgAl2O4-Mg2SiO4 composites were produced with simultaneous application of 80MPa pressure and induced output current of total power capacity (15 kW) within 2min. The sintering behavior, gain size and mechanical properties of MgAl2O4-Mg2SiO4 composites were investigated.
<title>Stereo mosaicing from a single moving video camera</title> (2001)

Panoramic stereo pictures are created by stitching together frames taken from a single moving video camera. Stereo panoramas can be created up to a full 360 degrees. The mosaicing process is robust and fast, and can be performed in real time. Mosaicing starts by computing the motion between the video frames. The video frames, together with the motion between frames computed in the previous step, are used to generate two panoramic pictures: One picture for the left eye and one picture for the right eye. Since the camera is moving, each object is viewed from different directions in different frames. Stitching together strips from the different video frames, selected to have the correct viewing directions for stereo perception, generates the panoramic stereo pictures. The stereo mosaicing process allows several features that were not available before: (1) The creation of stereo panoramic images in 360 degrees. (2) Automatic disparity control: increasing stereo disparity for far away objects, and reducing stereo disparity for close object, to give optimal stereo viewing in all directions and for all distances. (3) The creation of multiple pictures from multiple views, not limited to two views. This enables viewing the panoramic stereo pictures using lenticular technology.
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease (2020)

Abstract Background Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack of frank neuropathology from models based on common disease genes. Recent multi-cohort studies of postmortem human brain transcriptomes have identified a set of 30 gene co-expression modules associated with LOAD, providing a molecular catalog of relevant endophenotypes. Results This resource enables precise gene-based alignment between new animal models and human molecular signatures of disease. Here, we describe a new resource to efficiently screen mouse models for LOAD relevance. A new NanoString nCounter® Mouse AD panel was designed to correlate key human disease processes and pathways with mRNA from mouse brains. Analysis of the 5xFAD mouse, a widely used amyloid pathology model, and three mouse models based on LOAD genetics carrying APOE4 and TREM2*R47H alleles demonstrated overlaps with distinct human AD modules that, in turn, were functionally enriched in key disease-associated pathways. Comprehensive comparison with full transcriptome data from same-sample RNA-Seq showed strong correlation between gene expression changes independent of experimental platform. Conclusions Taken together, we show that the nCounter Mouse AD panel offers a rapid, cost-effective and highly reproducible approach to assess disease relevance of potential LOAD mouse models.
Computed Tomography (CT) of the Lungs of the Dog Using a Helical CT Scanner, Intravenous Iodine Contrast Medium and Different CT Windows (2007)

The aim of this study was to determine the accuracy of helical computed tomography (CT) for visualizing pulmonary parenchyma and associated formations in normal dogs. CT scan was performed by using intravenous contrast medium and by applying different types of CT windows: soft tissue and lung windows, and high-resolution computed tomography of the lung. This technique allowed, especially with lung window types, a good view of the parenchyma, bronchial tree, vascular structures and pleural cavity. The selected images, with high anatomical quality and tissue contrast, may be a reference for future clinical studies of this organ. Thus, helical CT is a promising non-invasive method of diagnosing a wide variety of pulmonary diseases in dogs.
Oxidation Flow Reactor Results in a Chinese Megacity Emphasize the Important Contribution of S/IVOCs to Ambient SOA Formation (2021)

Oxygenated volatile organic compounds (OVOCs) and secondary organic aerosol (SOA) formation potential of ambient air in Guangzhou, China was investigated using a field-deployed oxidation flow reactor (OFR). The OFR was used to mimic hours to weeks of atmospheric exposure to hydroxyl (OH) radicals within the 2-3 min residence time. A comprehensive investigation on the variation of VOCs and OVOCs as a function of OH exposure is shown. Substantial formation of organic acids and nitrogen-containing OVOC species were observed. Maximum SOA formation in the OFR was observed following 1-4 equiv days' OH exposure. SOA produced from known/measured VOC/IVOC precursors such as single-ring aromatics and long-chain alkanes can account for 52-75% of measured SOA under low NO<sub><i>x</i></sub> and 26-60% under high NO<sub><i>x</i></sub> conditions based on laboratory SOA yield parametrizations. To our knowledge, this is the first time that the contribution (8-20%) of long-chain (C<sub>8</sub>-C<sub>20</sub>) alkane oxidation to OFR SOA formation was quantified from direct measurement. By additionally estimating contribution from unmeasured semivolatile and intermediate volatility compounds (S/IVOCs) that are committed with C<sub>8</sub>-C<sub>20</sub> alkanes, 64-100% of the SOA formation observed in the OFR can be explained, signifying the important contribution of S/IVOCs such as large cyclic alkanes to ambient SOA.
Understanding Patient Questions about their Medical Records in an Online Health Forum: Opportunity for Patient Portal Design. (2017)

There are many benefits of online patient access to their medical records through technologies such as patient portals. However, patients often have difficulties understanding the clinical data presented in portals. In response, increasingly, patients go online to make sense of this data. One commonly used online resource is health forums. In this pilot study, we focus on one type of clinical data, laboratory results, and one popular forum, MedHelp. We examined patient question posts that contain laboratory results to gain insights into the nature of these questions and of the answers. Our analyses revealed a typology of confusion (i.e., topics of their questions) and potential gaps in traditional healthcare supports (i.e., patients' requests and situational factors), as well as the supports patients may gain through the forum (i.e., what the community provides). These results offer preliminary evidence of opportunities to redesign patient portals, and will inform our future work.
Dietary Selenium or Zinc Supplementation Restores Brain Lipid Composition and Membrane Fluidity in Protein-Undernourished Rats (2016)

Studies have shown that protein undernutrition (PU) modifies the membrane lipid composition in the intestine and liver, as well as in plasma and other areas. However, there is limited information on the effect of PU on synaptosomal membrane lipid composition and fluidity and the protective role of selenium (Se) and zinc (Zn), which is a major focus of the present study. For 10 weeks, rats were fed diets containing 16% casein, which constituted the adequate protein diet, or 5% casein, representing the PU diet. The animals were supplemented with Se and Zn at a concentration of 0.15 and 227 mg L-1, respectively, in drinking water for 3 weeks. The results showed a significant increase in total lipids, glycolipids, triglycerides, cholesterol, and the cholesterol/phospholipid (Chol/PL) ratio, and a significant reduction in phospholipids and membrane fluidity. Se and Zn supplementation to PU rats, however, significantly lowered total lipids, glycolipids, triglycerides, cholesterol, and the Chol/PL ratio, while phospholipids and membrane fluidity were significantly restored. It is concluded that a perturbed lipid composition induced by PU affects the membrane structure and fluidity, which in turn influences membrane functions. The study suggests that Se and Zn supplementation might be beneficial in restoring the lipid dyshomeostasis associated with PU.
An operational, multi-scale, multi-model system for consensus-based, integrated water management and policy analysis: The Netherlands Hydrological Instrument (2014)

Water management in the Netherlands applies to a dense network of surface waters for discharge, storage and distribution, serving highly valuable land-use. National and regional water authorities develop long-term plans for sustainable water use and safety under changing climate conditions. The decisions about investments on adaptive measures are based on analysis supported by the Netherlands Hydrological Instrument NHI based on the best available data and state-of-the-art technology and developed through collaboration between national research institutes. The NHI consists of various physical models at appropriate temporal and spatial scales for all parts of the water system. Intelligent connectors provide transfer between different scales and fast computation, by coupling model codes at a deep level in software. A workflow and version management system guarantees consistency in the data, software, computations and results. The NHI is freely available to hydrologists via an open web interface that enables exchange of all data and tools.
Treatment of chronic hepatitis C (2001)

Papers p 1151 

Chronic infection with the hepatitis C virus is extremely prevalent, averaging 1% to 2% of the world population. Fortunately, recognition of potential risk factors, changes in patterns of using injected drugs, and improved safety of the blood supply have led to a dramatic decline in the incidence of new hepatitis C virus infections in recent years. However, since most acutely infected patients become and remain chronically infected, the overall prevalence of chronic infection has not fallen. Chronic liver disease due to hepatitis C virus typically progresses slowly and usually does not result in major morbidity for many years. However, it is apparent that the large pool of patients with longstanding chronic hepatitis C is beginning to manifest the consequences of chronic infection and cirrhosis. In both the United Kingdom and the United States the incidence of hepatocellular carcinoma is increasing, deaths due to cirrhosis from chronic hepatitis C are on the rise, and hepatitis C is the leading indication for liver transplantation. In recent years, pharmacological treatment has had good results in patients with hepatitis C virus infection, with the virus being permanently eradicated …
21.9 A wearable EEG-HEG-HRV multimodal system with real-time tES monitoring for mental health management (2015)

Recently, wearable mental health management systems have been actively studied based on EEG monitoring and transcranial electrical stimulation (tES) [1]. It was reported that mental activities cause neural, vascular and autonomie domain changes in the human brain [2]. However, the previous neurofeedback system [1] used only neural domain information with low spatial resolution (∼10cm) EEG signals. Furthermore, EEG signals are easily interfered by tES stimulation signal, eye-blinking and EMG signals so that it is difficult to monitor in real-time during stimulation and to avoid electromagnetic noise for accurate mental health classification.
Seeking solutions in configurable computing (1997)

Configurable computing offers the potential of producing powerful new computing systems. Will current research overcome the dearth of commercial applicability to make such systems a reality? Unfortunately, no system to date has yet proven attractive or competitive enough to establish a commercial presence. We believe that ample opportunity exists for work in a broad range of areas. In particular, the configurable computing community should focus on refining the emerging architectures, producing more effective software/hardware APIs, better tools for application development that incorporate the models of hardware reconfiguration, and effective benchmarking strategies.
Applications of the Wittig Reaction in the Synthesis of Heterocyclic and Carbocyclic Compounds (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Generation of iris codes using 1D Log-Gabor filter (2010)

In general, a typical iris recognition system includes iris imaging, iris liveness detection, iris image quality assessment, and iris recognition. This paper presents an algorithm focusing on the last two steps. The novelty of this algorithm includes improving the speed and accuracy of the iris segmentation process, assessing the iris image quality such that only the clear images are accepted so as to reduce the recognition error, and producing a feature vector with discriminating texture features and a proper dimensionality so as to improve the recognition accuracy and computational efficiency. The Hough transform, polynomial fitting technique, and some morphological operations are used for the segmentation process. The phase data from 1D Log-Gabor filter is extracted and encoded efficiently to produce a proper feature vector. Experimental tests were performed using CASIA iris database (756 samples). These tests prove that the proposed algorithm has an encouraging performance.
Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells (2001)

1. The present work was devoted to the study of A3 adenosine receptors in Jurkat cells, a human leukemia line. 2. The A3 subtype was found by means of RT-PCR experiments and characterized by using the new A3 adenosine receptor antagonist [3H]-MRE 3008F20, the only A3 selective radioligand currently available. Saturation experiments revealed a single high affinity binding site with K(D) of 1.9+/-0.2 nM and B(max) of 1.3+/-0.1 pmol mg(-1) of protein. 3. The pharmacological profile of [3H]-MRE 3008F20 binding on Jurkat cells was established using typical adenosine ligands which displayed a rank order of potency typical of the A3 subtype. 4. Thermodynamic data indicated that [3H]-MRE 3008F20 binding to A3 subtype in Jurkat cells was entropy- and enthalpy-driven, according with that found in cells expressing the recombinant human A3 subtype. 5. In functional assays the high affinity A3 agonists Cl-IB-MECA and IB-MECA were able to inhibit cyclic AMP accumulation and stimulate Ca(2+) release from intracellular Ca(2+) pools followed by Ca(2+) influx. 6. The presence of the other adenosine subtypes was investigated in Jurkat cells. A1 receptors were characterized using [3H]-DPCPX binding with a K(D) of 0.9+/-0.1 nM and B(max) of 42+/-3 fmol mg(-1) of protein. A2A receptors were studied with [3H]-SCH 58261 binding and revealed a K(D) of 2.5+/-0.3 nM and a B(max) of 1.4+/-0.2 pmol mg(-1) of protein. 7. In conclusion, by means of the first antagonist radioligand [3H]-MRE 3008F20 we could demonstrate the existence of functional A3 receptors on Jurkat cells.
Stereoselective, biogenetically patterned synthesis of (.+-.)-aplysistatin (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective, biogenetically patterned synthesis of (.+-.)-aplysistatinJames D. White, Takeshi Nishiguchi, and Richard W. SkeeanCite this: J. Am. Chem. Soc. 1982, 104, 14, 3923–3928Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/ja00378a023https://doi.org/10.1021/ja00378a023research-articleACS PublicationsRequest reuse permissionsArticle Views323Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts