gebhart/patrepeval huggingface dataset:
Protection of mice from Semliki Forest virus infection by lymphocytes treated with low levels of interferon. (1989)

These studies provide the first evidence that adoptive transfer of syngeneic mouse (BALB/c) lymphocytes treated with low levels of mouse interferon (IFN)-alpha/beta can result in sufficient protection to protect mice from Semliki Forest virus (SFV) infection. Specifically, intraperitoneal inoculation of noncytotoxic lymphocytes treated exogenously with IFN (3 to 50 U/ml), washed exhaustively, and mixed with antibody to IFN-alpha/beta to neutralize any residual or early produced IFN, resulted (after repeated studies) in a 35% to 40% reduction in mortality of mice challenged with SFV (P less than or equal to .01), while inoculation of control lymphocytes had no effect. Direct administration of relatively high levels of IFN-alpha/beta (2,000 U/d) only moderately reduced the mortality (by 20%) in mice. Passive transfer of IFN-treated BALB/c mouse embryo cells also did not protect. The protection could not be attributed to carryover of IFN by the lymphocytes, endogenous IFN induction, enhanced cytotoxicity of endogenous splenocytes or peritoneal leukocytes, or early appearance of antiviral neutralizing antibody. Thus, the most likely cause of the observed protection is consistent with a unique mechanism that can be activated by the IFN-treated lymphocytes.
Interim estimates of 2017–18 seasonal influenza vaccine effectiveness — United States, February 2018 (2018)

This report documents the low effectiveness of this year’s influenza vaccine, both in normal and immunosuppressed individuals. This report documents the low effectiveness of this year’s influenza vaccine, both in normal and immunosuppressed individuals.
A 16-Gb/s differential I/O cell with 380fs RJ in an emulated 40nm DRAM process (2008)

This paper describes a 16-Gb/s differential bidirectional I/O transceiver cell in an emulated 40 nm DRAM process that has a fan-out of four-inverter delay (FO4) of 45 ps, resulting in a bit time that is only 1.4 FO4 delays long. The transceiver implements several techniques to achieve low jitter despite the slow process and constrained power consumption, including a quad rate clocking with closed-loop quadrature correction, a shared LC-PLL with an octagonal inductor in a three-metal process, and a data-dependent regulator. The transceiver has measured random jitter of 380 fs rms at the transmitter output and BER <10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-14</sup> while consuming 8 mW/Gb/s.
Dynamic wetting with viscous Newtonian and non-Newtonian fluids (2009)

We examine various aspects of dynamic wetting with viscous Newtonian and non-Newtonian fluids. Rather than concentrating on the mechanisms that relieve the classic contact line stress singularity, we focus on the behavior in the wedge flow near the contact line which has the dominant influence on wetting with these fluids. Our experiments show that a Newtonian polymer melt composed of highly flexible molecules exhibits dynamic wetting behavior described very well by hydrodynamic models that capture the critical properties of the Newtonian wedge flow near the contact line. We find that shear thinning has a strong impact on dynamic wetting, by reducing the drag of the solid on the fluid near the contact line, while the elasticity of a Boger fluid has a weaker impact on dynamic wetting. Finally, we find that other polymeric fluids, nominally Newtonian in rheometric measurements, exhibit deviations from Newtonian dynamic wetting behavior.
Periodic image artifacts from continuous-tone laser scanners (1986)

Continuous-tone images produced by mechanically scanned analog modulated laser beams are susceptible to image artifacts in the form of spatially periodic density variations due to machine errors in film transport velocity, raster scan-line placement, and scan-line intensity. The human eye is particularly sensitive to periodic patterns and, in ideal conditions, can detect peak-to-peak density variations as small as approximately 0.005 for spatial frequencies around 2-5 cycles/deg. The stringent requirements that this implies for the scanner hardware are derived. Particular attention is paid to the rotating polygon-type scanner, since this device currently provides the best combination of speed, image quality, and cost.
A principled approach towards debugging communicating event-loops (2017)

Since the multicore revolution, software systems are more and more inherently concurrent. Debugging such concurrent software systems is still hard, but in the recent years new tools and techniques are being proposed. For such novel debugging techniques, the main question is how to make sure that the proposed techniques are sufficiently expressive. In this paper, we explore a formal foundation that allows researchers to identify debugging techniques and assess how complete their features are in the context of message-passing concurrency. In particular, we describe a principled approach for defining the operational semantics of a debugger. Subsequently, we apply this technique to derive the operational semantics for a communicating event-loop debugger. We show that our technique scales for defining the semantics of a wide set of novel breakpoints recently proposed by systems such as REME-D and Kómpos. To the best of our knowledge, this is the first formal semantics for debugging asynchronous message passing-based concurrency models.
A novel vacuum filling process for polymeric optical waveguide fabrication (2002)

A novel vacuum filling process for polymeric optical waveguide fabrication has been presented in this paper. The polymeric optical waveguides fabricated by this process have successfully been obtained. Some initial tests about the polymeric waveguide have been done. The testing results indicate that the polymeric waveguide has high quality, while the process is simple, low-cost, easy to fabricate channel waveguide, good for mass production, and suitable for almost all polymers.
The (52-96) C-terminal domain of Vpr stimulates HIV-1 IN-mediated homologous strand transfer of mini-viral DNA (2003)

Viral integrase (IN) and Vpr are both components of the human immunodeficiency virus type 1 (HIV-1) pre-integration complex. To investigate whether these proteins interact within this complex, we investigated the effects of Vpr and its subdomains on IN activity in vitro. When a 21mer oligonucleotide was used as a donor and acceptor, both Vpr and its C-terminal DNA-binding domain [(52-96)Vpr] inhibited the integration reaction, whereas the (1-51)Vpr domain did not affect IN activity. Steady-state fluorescence anisotropy showed that both full-length and (52-96)Vpr bind to the short oligonucleotide, thereby extending previous observations with long DNA. The concentrations of the two proteins required to inhibit IN activity were consistent with their affinities for the oligonucleotide. The use of a 492 bp mini-viral substrate confirmed that Vpr can inhibit the IN-mediated reaction. However, the activity of (52-96)Vpr differed notably since it stimulated specifically integration events involving two homologous mini-viral DNAs. Order of addition experiments indicated that the stimulation was maximal when IN, (50-96)Vpr and the mini-viral DNA were allowed to form a complex. Furthermore, in the presence of (50-96)Vpr, the binding of IN to the mini-viral DNA was dramatically enhanced. Taken together, these data suggest that (52-96)Vpr stimulates the formation of a specific complex between IN and the mini-viral DNA.
Locked Chains (2007)

We know from Section 2.2.2 that configuration spaces of general linkages that are permitted to self-intersect, even in ℝ2, can have exponentially many connected components. On the other hand, we know from Section 5.1.1.1 (p. 59) and Section 5.1.2 (p. 66) that configuration spaces of open and closed 3D chains that are permitted to self-intersect have just one connected component. We also know from Section 5.3 (p. 70) that configuration spaces of planar chains have just one connected component when permitted to move into ℝ3 but forbidden to self-cross. We have until now avoided the most natural questions, which concern chains embedded in ℝd, with motion confined to the same space ℝd, without self-crossings. These questions avoid the generality of linkages on the one hand, and the special assumptions of planar embeddings or projections on the other hand.
Ammonium ion enhances the calcium-dependent gating of a mammalian large conductance, calcium-sensitive K+ channel (2001)

We observed that the current amplitude and activation of expressed, mouse brain large conductance, calcium-sensitive K+ channels (BKCa channels) may be reversibly enhanced following addition of low concentrations of the weakly permeant cation NH4+ to the cytoplasmic face of the channel in excised, inside-out membrane patches from HEK 293 cells. Conductance-voltage relations were left-shifted along the voltage axis by addition of NH4Cl in a concentration-dependent manner, with an EC50 of 18.5 mM. Furthermore, this effect was observed in the presence of cytosolic free calcium (approximately 1 microM), but was absent in a cytosolic bath solution containing nominally zero free calcium (e.g.. 5 mM EGTA only), a condition under which these channels undergo largely voltage-dependent gating. Recordings of single BKCa channel events indicated that NH4+ increased the channel open probability of single channel activity approximately 3-fold, but did not alter the amplitude of single channel currents. These findings suggest that the calcium-sensitive gating of mammalian BKCa channels may be modified by other ions present in cytosolic solution.
A Fast Electro-Thermal Model of Traction Inverters for Electrified Vehicles (2016)

In this paper, a fast electro-thermal model of traction inverters for electrified vehicles is proposed. First, a thermal model considering the thermal coupling is presented and experimentally verified. The impact of the thermal spreading effect, heat convection, and temperature-dependent material thermal properties on the accuracy of the linear assumption is investigated by ANSYS-Fluent simulation. In order to reduce the influence of the temperature-dependent thermal conductivity on the accuracy of the thermal model, the average temperature is applied to determine the thermal conductivity of the power module package. Second, an accurate temperature-dependent switching power loss model is represented as the lookup table through experimental measurements. In order to simplify the lookup table, the switching power loss is considered proportional to the dc-link voltage and, therefore, the inputs of the lookup table are current and temperature. Finally, a scheme to speed up the online junction temperature estimation is proposed by considering both the thermal network properties and the required accuracy. With the proposed calculation rate determination method, the total computational time for the junction temperature estimation is reduced significantly.
Virtual Screening of Constrained Cyclic Peptides as Mimics of Known Protein binding Peptides and Short linear Motifs (2012)

Pharmacophore matching strategies to mimic short linear motifs.
AN IMPROVED PROCEDURE FOR THE PREPARATION OF 9,10-DIBROMOANTHRACENE (2001)

An improved procedure is described for the dibromination of anthracene, a.ording 9,10-dibromoanthracene with yields > 95%.
Corneal Epithelial Toxicity after Intravitreal Methotrexate Injection for Vitreoretinal Lymphoma: Clinical and In Vitro Studies (2020)

Methotrexate is widely used as an intraocular chemotherapy for vitreoretinal lymphoma (VRL). Although corneal toxicity has been reported in patients after intravitreal methotrexate injections, the incidence, outcome, and mechanism of the toxicity are unclear. Herein, we performed a clinical study to evaluate the incidence, predisposing factors, and treatment outcome of corneal epitheliopathy associated with intravitreal methotrexate injection. In addition, we directly investigated cytotoxic effects and mechanisms of methotrexate in cultures of human corneal epithelial cells (CECs). Medical chart reviews revealed that corneal epitheliopathy occurred in 15 eyes (22.7%, 12 patients) out of 66 eyes (45 patients) after intravitreal methotrexate injections for treatment of VRL. The use of topical anti-glaucoma medication was significantly associated with development of corneal epitheliopathy. The epitheliopathy resolved in all patients 2.4 months after onset. In culture, methotrexate decreased the survival of CECs by inducing apoptosis, increasing oxidative stress, suppressing proliferation, and upregulating inflammatory cytokines. The addition of folinic acid significantly protected the cells from the methotrexate-induced toxicity. Hence, our results suggest that care should be taken to minimize the contact of methotrexate with corneal epithelium during injection, and folic or folinic acid supplementation might be beneficial for preventing corneal complications in patients undergoing intravitreal methotrexate injections.
Improved time-sidelobe performance in SAW RAC's using laser aided phase compensation (2003)

A modified form of laser direct writing has been applied to phase compensate reflecting array correlators (RAC). Accurate spatial correction patterns were written by directed laser light, trimming the phase response characteristics of a 3600 TB (time-bandwidth) RAC delay line fabricated on YZ lithium niobate. The resulting time sidelobes were suppressed to -44 dB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comparative effectiveness of plasma prepared with amotosalen‐UVA pathogen inactivation and conventional plasma for support of liver transplantation (2015)

In this retrospective study, IBS plasma provided therapeutic support of liver transplant not different from Q-FFP.
Theory of polar biaxial nematic phases (2002)

A theoretical model is proposed for describing the polar biaxial and uniaxial nematic phases observed in thermotropic liquid crystals formed from rodlike polyester molecules. The polarity and biaxiality are shown to result from the same molecular mechanism, i.e., they are associated with the same critical order parameter which consists of two vectors determining the average molecular orientations in the biaxial and uniaxial phases. The model allows us to determine the critical behavior and electric or magnetic field effects that characterize polar nematic phases and to analyze, at the phenomenological and molecular levels, remarkable properties that have been disclosed experimentally.
Two-Photon Laser (1981)

We have demonstrated a pulsed two-photon laser at the transition $3d^{2}D\ensuremath{-}2s^{2}S$ of atomic Li (frequency ${\ensuremath{\omega}}_{31}$) by (i) generation of a coherent light beam at ${\ensuremath{\omega}}_{x}$, stimulated by light pulses at ${\ensuremath{\omega}}_{1}={\ensuremath{\omega}}_{31}\ensuremath{-}{\ensuremath{\omega}}_{x}$, and (ii) single-pass amplification of injected light at ${\ensuremath{\omega}}_{3}=\frac{{\ensuremath{\omega}}_{31}}{2}$.
Construction and Operation of the National Landslide Forecast System Using Soil Water Index in Republic of Korea (2015)

본 연구의 목적은 국가 산사태 예보체계의 구축 배경 및 그 방법론을 소개하고, 지난 2년간의 운영 결과를 제시하는 것이다. 국가 산사태 예보체계는 전국 범위의 1시간 단위 산사태 위험 예보를 목표로 구축되었고, 이를 위하여 토양함수지수 개념과 탱크모델을 도입하였다. 강우 및 지질특성을 고려하여 구분된 11개 권역별로 탱크모델의 매개변수가 산사태 발생 강우자료를 이용하여 산정되었다. 국가 산사태 예보체계는 2013년부터 기상청에서 제공하는 실황 및 예측 강우자료를 이용하여 1시간 단위의 산사태 위험 예측정보를 제공하고 있으며, 이를 토대로 지자체에서는 산사태 주의보 및 경보를 발령하고 있다. 지난 2년간의 운영 결과, 2013년 420건, 2014년에는 248건의 산사태 위험 예측정보가 생산되었으며, 이 중에서 산사태 예보로 발령되지 않은 건수는 각각 33건(7.9%), 17건(6.9%)이었다. 또한, 2013년에는 발생한 212건의 산사태 중 1건만이 산사태 위험 예측정보 생산 및 예보 발령이 되지 않았던 반면, 2014년에는 72건의 산사태 중 36건에 대한 예측정보 생산 및 예보 발령이 이루어지지 않았다. 추후 현행 예보체계의 실효성 향상을 위해서는 입력 강우자료의 정확성 향상, 정기적인 매개변수 수정 및 예보 발령 수준의 적절한 조정 등이 필요할 것으로 제안되었다. The objective of this study was to describe the background and methodology of the current operational national landslide forecast system in Republic of Korea and analyze its operational results in the past two years. Soil water index and tank model were employed as the national landslide forecast system with a goal of pre-1-hour forecast for landslide likelihood in a national scale. The tank model was parameterized with the past rainfall data inducing landslides in each divided eleven region after considering rainfall and geological characteristics in the whole country. The national landslide forecast system have provided local administrations with the information of predicted warnings calculated with observed and predicted rainfall data by Korea Weather Administration in a hour since 2013, and they issue landslide warnings including landslide watch and alert based on the information. As results of its two-year-operation, 420 and 248 predicted warnings were calculated in 2013 and 2014, respectively. But, 33 of 420 in 2013 and 17 of 248 in 2014 were not finally issued in reality, accounting for 7.9% and 6.9%, respectively. Also, predicted warnings were not calculated for 36 of 72 landslides occurred in 2014 compared to only one out of 212 landslides in 2013. Overall, improvement of input rainfall data accuracy, regular revision of tank model parameters, and relevant adjustment of landslide warning issuing level were suggested to improve the efficiency of the national landslide forecast system.
Structural Design of Dual-Mode Ramjets and Associated System Issues (Conception structurale des statoreacteurs mixtes et defis "systeme" associes) (2010)

Abstract : The RTO-AVT-VKI course HIGH SPEED PROPULSION: ENGINE DESIGN INTEGRATION AND THERMAL MANAGEMENT was given at the Von Karman Institute in September 2010 and in the Wright State University (Dayton, Ohio) in early December 2010. The present lecture deals with the overall system analysis of scramjets, considering what is the optimum number of engine modules; comparison between fixed or movable geometry; effect of engine mass and size to on-trajectory-performance of an air-breathing space launcher. The results are based on published information, and additional details, presented to the lecturers, can be found in the references.
CoupledCF: Learning Explicit and Implicit User-item Couplings in Recommendation for Deep Collaborative Filtering (2018)

Non-IID recommender system discloses the nature of recommendation and has shown its potential in improving recommendation quality and addressing issues such as sparsity and cold start. It leverages existing work that usually treats users/items as in- dependent while ignoring the rich couplings within and between users and items, leading to limited performance improvement. In reality, users/items are related with various couplings existing within and between users and items, which may better ex- plain how and why a user has personalized pref- erence on an item. This work builds on non- IID learning to propose a neural user-item cou- pling learning for collaborative filtering, called CoupledCF. CoupledCF jointly learns explicit and implicit couplings within/between users and items w.r.t. user/item attributes and deep features for deep CF recommendation. Empirical results on two real-world large datasets show that CoupledCF significantly outperforms two latest neural recom- menders: neural matrix factorization and Google’s Wide&amp;Deep network.
Conformational Differences Between C- and O-Glycosides: The -C-Mannobiose/-O-Mannobiose Case (1999)

NMR spectroscopy and molecular mechanics calculations have demonstrated that the conformational behavior of α-C-mannobiose (1) is rather different from that of its natural analogue Manα(1→2)Man (2); this has implications for the possibility of biological use of C-disaccharides.
Long-Term Cumulative Effects of Repeated Botulinum Toxin Type A Injections on Brow Position (2019)

Hexsel, Doris MD; Dal'Forno, Taciana MD, PhD; Hexsel, Camile MD; OliveiraCamozzato, Fernanda MD Author Information
Acceptance and Commitment Therapy for Psychosis (2022)

There has been increasing interest in the psychosocial treatment of psychosis based on Acceptance and Commitment Therapy (ACT), which has the primary aim of helping people more effectively engage in their lives guided by their values. The approach includes various techniques to change one’s relationship to private experiences, such as hallucination and delusion, rather than rectifying the contents of these experiences. Using the six core processes of the ACT model (hexaflex) tailored to the characteristics of people with psychosis may help alleviate their distress from the symptoms and shape pragmatic value-consistent behaviors. This review introduces the ACT model of psychosis and illustrates the specific ways of applying ACT to people with psychotic experiences.
Street lighting control based on LonWorks power line communication (2008)

Public lighting managers have known that they could lower the operating costs of their systems if they could cost effectively collect the critical data needed to make better planning decisions. Lighting engineers have conceived of new designs to improve public safety and reduce energy consumption only to be stymied by an inability to economically control every luminaire in the system. This paper describes street lighting control system based on LonWorks[1] power line communication on demand market.
Super‐resolution reconstruction of diffusion parameters from diffusion‐weighted images with different slice orientations (2015)

The proposed SRR method substantially increases the spatial resolution of MRI that can be obtained in a clinically feasible scan time.
Physical activity (PA) levels during recovery from severe acute exacerbations of COPD (AECOPD) (2014)

Introduction : Physical activity (PA) is a predictor of outcome in patients with COPD. However, there are few data on PA during recovery from AECOPD requiring hospitalisation. We hypothesised that PA would differ between those COPD patients who required readmission or treatment for a re-exacerbation within 28 days of hospital discharge and those who did not. Methods : Patients hospitalised with AECOPD were enrolled and monitored continuously with a uniaxial accelerometer (Actiwatch Spectrum, Philips Respironics, PN, USA) between the day of admission and 28 days post- discharge. Mean total daily activity count (AC) for the entire monitoring period was calculated for each patient. Readmissions and re-exacerbations within 28 days of discharge were recorded prospectively from the hospital and the primary care physician records. Results : 51 patients were recruited (47% male, 68±9years, FEV 1 31±15 %predicted. 10 patients had a re-exacerbation or readmission within 28days of discharge. GOLD III patients had a non-significant trend to higher AC (170±76kiloAC) compared with GOLD IV patients (140±46kiloAC). AC was lower in patients who re-exacerbated or were readmitted within 28 days post- discharge compared with those who did not (112±33kiloAC vs. 151±72kiloAC, p=0.01). Conclusion : Disease severity, as measured by GOLD staging, did not influence PA in this cohort of hospitalised patients with AECOPD. However, patients who re-exacerbated at home or required readmission within four weeks of discharge had lower levels of daily activity than those that did not. PA measured by accelerometry potentially could be used as part of a telehealth system to monitor COPD patients at home.
Reservoir monitoring using induced seismicity at a petroleum field in Oman (2008)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Earth, Atmospheric, and Planetary Sciences, 2008.