gebhart/patrepeval huggingface dataset:
Supplementary Figure S2 from 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer (2023)

&lt;p&gt;Supplementary Figure S2 shows A, the first intron of EIF4E-BP1 as an active target for epigenetic regulation of transcription; and B, 4NQO-induced tumors in eif4e-bp1/2 KO mice.&lt;/p&gt;
Galactose-Decorated Cross-Linked Biodegradable Poly(ethylene glycol)-b-poly(ε-caprolactone) Block Copolymer Micelles for Enhanced Hepatoma-Targeting Delivery of Paclitaxel (2011)

The inferior in vivo stability of micellar drugs has been a prime challenge for their application in targeted drug delivery. Here we report on novel galactose-decorated covalently cross-linked biodegradable micelles based on photo-cross-linkable poly(ethylene glycol)-b-poly(acryloyl carbonate)-b-poly(ε-caprolactone) (PEG-PAC-PCL) and galactose-conjugated PEG-PCL (Gal-PEG-PCL) copolymers for enhanced hepatoma-targeting delivery of paclitaxel (PTX). The molecular weight of PEG in Gal-PEG-PCL was higher than that in PEG-PAC-PCL, thereby fully exposing Gal ligands at the micellar surface. These micelles, either with or without loading of PTX, were readily cross-linked by UV irradiation to afford micelles with small sizes (ca. 79-94 nm) and enhanced stability. The in vitro release studies confirmed that drug release from cross-linked micelles was significantly inhibited. Interestingly, MTT assays showed that Gal-decorated PTX-loaded cross-linked micelles retained a high antitumor activity in HepG2 cells, which was much more effective than PTX-loaded cross-linked micelles without Gal ligands and comparable to Gal-decorated PTX-loaded non-cross-linked micelles. Remarkably, the preliminary in vivo antitumor efficacy studies in SMMC-7721 tumor (human hepatoma)-bearing nude mice revealed that Gal-decorated PTX-loaded cross-linked micelles inhibited the growth of the human hepatoma more effectively than PTX-loaded cross-linked micelles as well as Gal-decorated PTX-loaded non-cross-linked micelles. These results indicate that Gal-decorated cross-linked PEG-PCL micelles have great potential in liver tumor-targeted chemotherapy.
Direct His‐Bundle Pacing: (2004)

Direct His-bundle pacing (DHBP) produces rapid sequential multisite synchronous ventricular activation and, therefore, would be an ideal alternative to right ventricular apical (RVA) pacing. In 54 patients with cardiomyopathy, ejection fraction (EF) 0.23 +/- 0.11, persistent atrial fibrillation, and normal QRS < 120 ms. DHBP was attempted. This was successful in 39 patients. In seven patients, the effect of increasing heart rate on contractility (Treppe effect) was investigated. Twelve patients who also received a RVA lead underwent cardiopulmonary testing. After a mean follow-up of 42 months, 29 patients are still alive with EF improving from 0.23 +/- 0.11 to 0.33 +/- 0.15. Functional class improved from 3.5 to 2.2. DP/dt increased at each pacing site (P < 0.05) as the heart rate increased to 60, 100, and 120 beats/min. Rise in dP/dt by DHBP pacing at 120 beats/min was at least 170 +/- mmHg/s, greater than any other site in the ventricle (P < 0.05). Cardiopulmonary testing revealed longer exercise time (RVA 255 +/- 110 s) (His 280 +/- 104 s) (P < 0.05), higher O2 uptake (RVA 15 +/- 4 mL/kg per minute) (His 16 +/- 4 mL/kg minute) (P < 0.05), and later anaerobic threshold (RVA 126 +/- 71 s) (His 145 +/- 74 s) (P < 0.05) with DHBP compared to RVA pacing. Long-term DHBP is safe and effective in humans. DHBP is associated with a superior Treppe effect and increased cardiopulmonary reserve when compared to RVA pacing.
Erratum: ’’On fiber-optic hydrophone sensitivity’’ [ J. Acoust. Soc. Am. 64, 1286 (1978)] (1979)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Peter Shajenko, James P. Flatley, Mark B. Moffett; Erratum: ''On fiber‐optic hydrophone sensitivity'' [ J. Acoust. Soc. Am. 64, 1286 (1978)]. J. Acoust. Soc. Am. 1 November 1979; 66 (5): 1557. https://doi.org/10.1121/1.383698 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Being on the receiving end of a government laser safety inspectors formal laboratories inspection (2019)

This paper attempts to address the issues raised when the Specialist Radiation Inspectorate for the Health and Safety Executive - the UK Government Executive Inspectorate for Health and Safety comes to call. The specific questions this paper attempts to address: Where did we come from as an organisation in terms of laser safety compliance?How our organisation structured and was this appropriate?What local issues did we have?What lessons did we take away from the experience? This paper examines the practical issues posed when one of the UKs largest technical Universities with possibly the most diverse range of laser research laboratories has moved towards full UK laser safety regulatory compliance.
Recurrent Inhibition to the Medial Nucleus of the Trapezoid Body in the Mongolian Gerbil (Meriones Unguiculatus) (2016)

Principal neurons in the medial nucleus of the trapezoid body (MNTB) receive strong and temporally precise excitatory input from globular bushy cells in the cochlear nucleus through the calyx of Held. The extremely large synaptic currents produced by the calyx have sometimes led to the view of the MNTB as a simple relay synapse which converts incoming excitation to outgoing inhibition. However, electrophysiological and anatomical studies have shown the additional presence of inhibitory glycinergic currents that are large enough to suppress action potentials in MNTB neurons at least in some cases. The source(s) of glycinergic inhibition to MNTB are not fully understood. One major extrinsic source of glycinergic inhibitory input to MNTB is the ventral nucleus of the trapezoid body. However, it has been suggested that MNTB neurons receive additional inhibitory inputs via intrinsic connections (collaterals of glycinergic projections of MNTB neurons). While several authors have postulated their presence, these collaterals have never been examined in detail. Here we test the hypothesis that collaterals of MNTB principal cells provide glycinergic inhibition to the MNTB. We injected dye into single principal neurons in the MNTB, traced their projections, and immunohistochemically identified their synapses. We found that collaterals terminate within the MNTB and provide an additional source of inhibition to other principal cells, creating an inhibitory microcircuit within the MNTB. Only about a quarter to a third of MNTB neurons receive such collateral inputs. This microcircuit could produce side band inhibition and enhance frequency tuning of MNTB neurons, consistent with physiological observations.
Cobalt(II)-Catalyzed Conversion of Allylic Alcohols/Acetates to Allylic Amides in the Presence of Nitriles (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCobalt(II)-Catalyzed Conversion of Allylic Alcohols/Acetates to Allylic Amides in the Presence of NitrilesManoj Mukhopadhyay, M. Madhava Reddy, G. C. Maikap, and Javed IqbalCite this: J. Org. Chem. 1995, 60, 9, 2670–2676Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/jo00114a013https://doi.org/10.1021/jo00114a013research-articleACS PublicationsRequest reuse permissionsArticle Views1672Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cellular genes possibly involved in the transformation process of the human melanoma cell line XP44 RO (Mel). (1995)

P44 Ro (Mel) is a human malignant melanoma cell line derived from a testicular metastasis in a DNA repair deficient, xeroderma pigmentosum patient. This line harbors a N-ras gene mutated in codon 61. To investigate other cellular genes possibly contributing to the expression of its transformed phenotype, four XP44 revertant cell lines were isolated by different selection procedures and the association of the level of expression of various oncogenes (including N-ras) and tumor suppressor genes with the selection for the revertant phenotype was determined. The revertants exhibited a significant but variable degree of phenotypic reversion, according to the selective pressure to which they were submitted, and a phenotypic stability dependent on their constant maintenance in selective medium. Back-revertant lines were isolated by culturing revertant lines in control medium for several weeks. The comparison between parental, revertant and back-revertant cells has revealed that, beyond the mutation in codon 61 of N-ras, two groups of genes appear to be also implicated in the transformation process of XP44 RO (Mel) cells: one group, comprising pim A, trk, Rb and p53, whose expression is independent of the cell selection conditions; the other group, comprising Ha-ras, N-ras, neu 1, fos and met H, whose expression is more or less dependent upon such conditions. The myc gene is apparently not involved in this phenomenon. These results, besides strengthening the concept that carcinogenesis is a multigenic process, suggest that diverse mechanisms can lead to the transformed phenotype, but that these mechanisms might have some pathway(s) in common.
A Meta-Analysis of the Performance of a Blood-Based Exposure Response Gene Signature Across Clinical Studies on the Tobacco Heating System 2.2 (THS 2.2) (2019)

As part of emerging tobacco harm reduction strategies, modified risk tobacco products (MRTP) are being developed to offer alternatives that have the potential to reduce the individual risk and population harm compared with smoking cigarettes for adult smokers who want to continue using tobacco and nicotine products. MRTPs are defined as any tobacco products that are distributed for use to reduce harm or the risk of tobacco-related disease associated with commercially marketed tobacco products. One such candidate MRTP is the Tobacco Heating System (THS) 2.2, which does not burn tobacco but instead heats it, thus producing significantly reduced levels of harmful and potentially harmful constituents compared with cigarettes. The clinical assessment of candidate MRTPs requires the development of exposure-response markers to distinguish current smokers from either nonsmokers or former smokers with high specificity and sensitivity. Toward this end, a whole blood-derived gene signature was previously developed and reported. Four randomized, controlled, open-label, three-arm parallel group reduced exposure clinical studies have been conducted with subjects randomized to three arms: switching from cigarettes to THS 2.2, continuous use of cigarettes, or smoking abstinence. These clinical studies had an investigational period of 5 days in confinement, which was followed by an 85-day ambulatory period in two studies. Here we tested the previously developed blood-derived signature on the samples derived from those clinical studies. We showed that in all four studies, the signature scores were reduced consistently in subjects who either stopped smoking or switched to THS 2.2 compared with subjects who continued smoking cigarettes.
Engine control system having pressure-based timing (2023)

A control system for an engine having a first cylinder and a second cylinder is disclosed having a first engine valve movable to regulate a fluid flow of the first cylinder and a first actuator associated with the first engine valve. The control system also has a second engine valve movable to regulate a fluid flow of the second cylinder and a sensor configured to generate a signal indicative of a pressure within the first cylinder. The control system also has a controller that is in communication with the first actuator and the sensor. The controller is configured to compare the pressure within the first cylinder with a desired pressure and selectively regulate the first actuator to adjust a timing of the first engine valve independently of the timing of the second engine valve based on the comparison.
Sorption of Mannans to Different Fiber Surfaces: An Evolution of Understanding (2003)

Mannans are sorbed to a high extent onto chemical pulps, giving the fibers and the formed sheet superior properties. This paper reviews the use of mannans in papermaking, both as additives and as naturally present polysaccharides. The effect of mannans in mechanical pulping and papermaking, including the interaction with colloidal wood resin droplets, is, furthermore, discussed.
Truncation compensated 3D-OSEM reconstruction in pinhole SPECT (2008)

99 Objectives: Pinhole SPECT can provide high resolution with reasonable sensitivity when a collimator is close to an object, but truncation causes artifact and decreases quantitative accuracy. Defrise et al proposed new reconstruction theory to prevent overestimation due to truncation, and validated the theory by simulation with 2D X-ray CT. In this study, we expanded this method to truncation-compensated 3DOSEM reconstruction (TC-3DOSEM) for pinhole SPECT. Simulation and rat studies were performed to validate TC-3DOSEM. Methods: According to Defrise theory, two conditions are assigned. First, field of view contains null or background counts, namely, a known value. Second, reconstruction space is defined large enough to contain the whole of object. This is held in 3D domain in our pinhole SPECT. TC-3DOSEM was validated by simulation and rat studies using microSPECT and Tl-201. A target of imaging was rat heart and the surrounding was truncated. Additionally, to evaluate for larger truncated area, we artificially generated data with the different amounts (22% and 48%) of truncation from rat experimental data. TC-3DOSEM and conventional method were compared. Results: In simulation, myocardial counts were overestimated about 20% by conventional method, and were almost consistent with original counts by TC-3DOSEM. In rat study, conventional method significantly overestimated the counts along with the amount of truncation. TC-3DOSEM eliminated overestimation and the counts were consistent across all data sets with different amount of truncation (error of 0.7%). Conclusions: These studies demonstrated that TC-3DOSEM compensated systematic errors attributed to truncation in pinhole SPECT reconstruction, while conventional method caused significant overestimation.
Acetylation of Benzenesulfonylacetone with Acetic Anhydride by Means of Boron Fluoride to Form the Terminal Methyl Derivative1,2 (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcetylation of Benzenesulfonylacetone with Acetic Anhydride by Means of Boron Fluoride to Form the Terminal Methyl Derivative1,2DONALD F. TAVARES, WILLIAM IVO O'SULLIVAN, and CHARLES R. HAUSERCite this: J. Org. Chem. 1962, 27, 4, 1251–1254Publication Date (Print):April 1, 1962Publication History Published online1 May 2002Published inissue 1 April 1962https://pubs.acs.org/doi/10.1021/jo01051a032https://doi.org/10.1021/jo01051a032research-articleACS PublicationsRequest reuse permissionsArticle Views249Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modeling of SNCR denitration system based on adaptive weight particle swarm optimization (2020)

Abstract In view of the improvement of NO X emission control requirements for coal-fired units, traditional PID controllers have been unable to effectively control large delay, large inertia, nonlinear, time-varying SNCR denitration systems, and most advanced control algorithms are often object-based models. Therefore, a model of SNCR denitration system based on adaptive weight particle swarm optimization algorithm is established. A 2×200MW heating steam turbine generator set equipped with a 2×705t/h circulating fluidized bed boiler was used as the test unit, and the selective non-catalytic reduction technology denitration system was analysed. The particle swarm optimization algorithm with adaptive weights was used to model the relationship between the urea flow rate and the NOX concentration at the chimney outlet of the SNCR denitration system under working conditions of 140 MW, 170 MW and 200 MW, respectively, to provide a process for the automatic control of the SNCR denitration systemmodel. Apply the actual data from the field to verify the model. The results show that the error between the output of the model and the actual operational data is within the allowable range, which verifies the validity of the model. This result opens up a new path for the particle swarm optimization algorithm to model the SNCR denitration process, and promotes the application of intelligent algorithms in other industrial processes.
Shortcut selection in RDF databases (2011)

An increasing amount of data produced nowadays is in RDF format. While significant work has been performed on view selection and query optimization algorithms in relational database systems, little attention has been paid to the problem of optimizing the performance of query workloads in RDF databases. In this paper we propose the notion of shortcuts, as a method for reducing the query processing cost. We then devise a greedy algorithm that, given a space constraint and a query workload in an RDF database, seeks to select the optimal shortcuts to materialize. Our experiments validate our approach and demonstrate that our algorithm manages to significantly reduce the query processing cost while keeping space requirements low.
Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy (2004)

We developed an oblique-incidence reflectivity difference (OI-RD) scanning microscope for label-free imaging of microarrays of biomolecules upon solid substrates. We demonstrate that hybridization reactions in an oligonucleotide microarray fabricated upon a glass slide can be detected by such an OI-RD microscope.
Charge-dependent flow induced by magnetic and electric fields in heavy ion collisions (2018)

We investigate the charge-dependent flow induced by magnetic and electric fields in heavy-ion collisions. We simulate the evolution of the expanding cooling droplet of strongly coupled plasma hydrodynamically, using the iEBE-VISHNU framework, and add the magnetic and electric fields as well as the electric currents they generate in a perturbative fashion. We confirm the previously reported effect of the electromagnetically induced currents [Gursoy et al., Phys. Rev. C 89, 054905 (2014)], that is a charge-odd directed flow $\mathrm{\ensuremath{\Delta}}{v}_{1}$ that is odd in rapidity, noting that it is induced by magnetic fields (\`a la Faraday and Lorentz) and by electric fields (the Coulomb field from the charged spectators). In addition, we find a charge-odd $\mathrm{\ensuremath{\Delta}}{v}_{3}$ that is also odd in rapidity and that has a similar physical origin. We furthermore show that the electric field produced by the net charge density of the plasma drives rapidity-even charge-dependent contributions to the radial flow $\ensuremath{\langle}{p}_{T}\ensuremath{\rangle}$ and the elliptic flow $\mathrm{\ensuremath{\Delta}}{v}_{2}$. Although their magnitudes are comparable to the charge-odd $\mathrm{\ensuremath{\Delta}}{v}_{1}$ and $\mathrm{\ensuremath{\Delta}}{v}_{3}$, they have a different physical origin, namely the Coulomb forces within the plasma.
Crystal packing in three related disaccharides: precursors to heparan sulfate oligosaccharides (2015)

The three title compounds form part of a set of important precursor dissacharides which lead to novel therapeutics, in particular for Alzheimer's disease. All three crystallize as poorly diffracting crystals with one independent mol-ecule in the asymmetric unit. Two of them are isostructural: 4-meth-oxy-phenyl 4-O-[6-O-acetyl-2-azido-3-O-benzyl-2-de-oxy-4-O-(9-fluor-en-yl-methyl-oxycarbon-yl)-α-d-gluco-pyranos-yl]-2-O-benzoyl-3-O-benzyl-6-O-chloro-acetyl-α-l-ido-pyran-oside, C59H56ClN3O16, (I), the ido-relative of a reported gluco-disaccharide [Gainsford et al., 2013 ▶). Acta Cryst. C69, 679-682] and 4-meth-oxy-phenyl 4-O-[6-O-acetyl-2-azido-3-O-benzyl-2-de-oxy-4-O-(9-fluorenyl-methyl-oxycarbon-yl)-α-d-gluco-pyranos-yl]-2-O-benzoyl-3-O-benzyl-6-O-meth-oxy-acetyl-α-l-ido-pyran-oside, C60H59N3O17, (II). Both exhibit similar conformational disorder of pendant groups. The third compound 4-meth-oxy-phenyl 4-O-[6-O-acetyl-2-azido-3,4-di-O-benzyl-2-de-oxy-α-d-gluco-pyranos-yl]-2-O-benzoyl-3-O-benzyl-6-O-meth-oxy-oacetyl-β-d-gluco-pyran-oside, C52H55N3O15, (III), illustrates that a slightly larger set of weak inter-molecular inter-actions can result in a less disordered mol-ecular arrangement. The mol-ecules are bound by weak C-H⋯O(ether) hydrogen bonds in (I) and (II), augmented by C-H⋯π inter-actions in (III). The absolute configurations were determined, although at varying levels of significance from the limited observed data.
Resurfacing Arthroplasty of the Humerus (2007)

Resurfacing arthroplasty of the shoulder is not a new concept in orthopedic surgery. Although only a few reports describe the indications, technique, and results, experience with these devices continues to grow. A specific advantage of resurfacing arthroplasty, the concept of a bone-preserving procedure, may prove to be particularly important in younger patients who require prosthetic arthroplasty surgery. The indications and surgical technique are illustrated in this review. Our early clinical results with 2 humeral resurfacing prostheses reflect those of other published reports; namely, favorable clinical outcomes can be expected.
Steroid and asparaginase-induced hyperlipidemia in leukemia. (1995)

A case presentation of a ten year old girl diagnosed with acute lymphoblastic leukemia is described. Following her combination chemotherapy regimen with steroids and asparaginase, a most interesting development of hyperlipidemia of the blood plasma and lipemia retinalis was noted.