gebhart/patrepeval huggingface dataset:
OXSA: An open-source magnetic resonance spectroscopy analysis toolbox in MATLAB (2017)

In vivo magnetic resonance spectroscopy provides insight into metabolism in the human body. New acquisition protocols are often proposed to improve the quality or efficiency of data collection. Processing pipelines must also be developed to use these data optimally. Current fitting software is either targeted at general spectroscopy fitting, or for specific protocols. We therefore introduce the MATLAB-based OXford Spectroscopy Analysis (OXSA) toolbox to allow researchers to rapidly develop their own customised processing pipelines. The toolbox aims to simplify development by: being easy to install and use; seamlessly importing Siemens Digital Imaging and Communications in Medicine (DICOM) standard data; allowing visualisation of spectroscopy data; offering a robust fitting routine; flexibly specifying prior knowledge when fitting; and allowing batch processing of spectra. This article demonstrates how each of these criteria have been fulfilled, and gives technical details about the implementation in MATLAB. The code is freely available to download from https://github.com/oxsatoolbox/oxsa.
Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF) (2017)

Primary cilia play central roles in signaling during metazoan development. Several key regulators of ciliogenesis and ciliary signaling are mutated in humans, resulting in a number of ciliopathies, including Joubert syndrome (JS). ARL13B is a ciliary GTPase with at least three missense mutations identified in JS patients. ARL13B is a member of the ADP ribosylation factor family of regulatory GTPases, but is atypical in having a non-homologous, C-terminal domain of ∼20 kDa and at least one key residue difference in the consensus GTP-binding motifs. For these reasons, and to establish a solid biochemical basis on which to begin to model its actions in cells and animals, we developed preparations of purified, recombinant, murine Arl13b protein. We report results from assays for solution-based nucleotide binding, intrinsic and GTPase-activating protein-stimulated GTPase, and ARL3 guanine nucleotide exchange factor activities. Biochemical analyses of three human missense mutations found in JS and of two consensus GTPase motifs reinforce the atypical properties of this regulatory GTPase. We also discovered that murine Arl13b is a substrate for casein kinase 2, a contaminant in our preparation from human embryonic kidney cells. This activity, and the ability of casein kinase 2 to use GTP as a phosphate donor, may be a source of differences between our data and previously published results. These results provide a solid framework for further research into ARL13B on which to develop models for the actions of this clinically important cell regulator.
ChemInform Abstract: An Approach to the Synthesis of the Naphthyridinomycin Alkaloids: the Synthesis of Two Subunits. A Mannich‐Like Approach to Naphthyridinomycin. (1985)

Abstract Zum Aufbau von Naphthyridinomycin‐Alkaloiden wie (XIV) werden die Ausgangsverbindungen (V) bzw. (XIb) synthetisiert.
ChemInform Abstract: Photoelectrochemical Investigations of Passive Films on Titanium Electrodes. (1986)

Abstract The results of photocurrent spectra and the potential dependence of the photocurrent measured at passive films formed on Ti electrodes in 1 M H 2 SO 4 at constant potentials in the range 4‐105 V show four different types of film behavior depending on the film thickness.
A probable conformational difference between recombinant and urinary erythropoietins (1997)

Urinary and recombinant human erythropoietin differ with respect to ease of iodination, inactivation by iodination, second derivative and circular dichroic spectra, rate of inactivation by trypsin and glycosylation pattern. All of these differences are compatible with a significant difference in conformation of these two forms of erythropoietin.
Susceptibilities and speed of sound from the Polyakov-Nambu-Jona-Lasinio model (2006)

We present the Taylor expansion coefficients of the pressure in quark number chemical potential ${\ensuremath{\mu}}_{0}={\ensuremath{\mu}}_{B}/3={\ensuremath{\mu}}_{u}={\ensuremath{\mu}}_{d}$, for the strongly interacting matter as described by the Polyakov-Nambu-Jona-Lasinio (PNJL) model for two light degenerate flavors of quarks $u$ and $d$. The expansion has been done up to eighth order in ${\ensuremath{\mu}}_{0}$, and the results are consistent with recent estimates from Lattice. We have further obtained the specific heat ${C}_{V}$, squared speed of sound ${v}_{s}^{2}$, and the conformal measure $\mathcal{C}$.
Reconstruction of allopolyploid Brassicas through non-homologous recombination: introgression of resistance to pod shatter inBrassica napus (1990)

Summary Pod shattering of rapeseed ( Brassica napus ) causes serious yield loss. Genetic resistance to shattering has been introgressed into B. napus from B. juncea . This followed from allosyndetic pairing between chromosomes of B and C genomes in the interspecific F1 hybrid, B. juncea × B. napus (2 n = 37, AABC). The reconstituted B. napus plant showed regular meiosis with 19 bivalents and had pollen and seed fertility of 84 and 23% respectively. An approach is suggested for achieving introgression from monogenomic diploids to digenomic allopolyploids that exploits non-homologous recombination.
An Update From the 5G Media Action Group (5G-MAG) (2022)

Connectivity is becoming a key element in the production and distribution of multimedia content to address audiences worldwide. The development and use of technologies traditionally optimized for specific media applications are steadily being replaced by technologies playing in the global consumer market domain and able to rapidly evolve. The plethora of devices now able to consume media content, and the freedom given to users in doing so is massive. Connected devices now include smart TVs, PCs, smartphones, tablets, car infotainment systems, smart speakers, as well as smart glasses, or head-mounted devices. The focus on media content is shifting from just linear to more interactive, social, even gaming-like, location-dependent, targeted, personalized and immersive.
Heroin Overdoses and Duty of Care (2001)

This paper presents results from a national survey of Australians which canvassed reporting behaviours of witnesses to heroin overdoses and why some of those overdoses were not reported to ambulance or other medical professionals for assistance. The authors describe the legal consequences of not calling for medical assistance and then consider policy implications.
Radioimmunoassay for Human Gastrin Using Unconjugated Gastrin as an Antigen (1968)

Journal Article Radioimmunoassay for Human Gastrin Using Unconjugated Gastrin as an Antigen Get access WILLIAM D. ODELL, WILLIAM D. ODELL 1Department of Medicine and Surgery, Harbor General Hospital 1000 West Carson Street, Torrance, California 90509; Department of UCLA School of Medicine Los Angeles, California Search for other works by this author on: Oxford Academic Google Scholar A. CRANE CHARTERS, A. CRANE CHARTERS 1Department of Medicine and Surgery, Harbor General Hospital 1000 West Carson Street, Torrance, California 90509; Department of UCLA School of Medicine Los Angeles, California Search for other works by this author on: Oxford Academic Google Scholar WARREN D. DAVIDSON, WARREN D. DAVIDSON 1Department of Medicine and Surgery, Harbor General Hospital 1000 West Carson Street, Torrance, California 90509; Department of UCLA School of Medicine Los Angeles, California Search for other works by this author on: Oxford Academic Google Scholar JAMES C. THOMPSON JAMES C. THOMPSON 1Department of Medicine and Surgery, Harbor General Hospital 1000 West Carson Street, Torrance, California 90509; Department of UCLA School of Medicine Los Angeles, California Search for other works by this author on: Oxford Academic Google Scholar The Journal of Clinical Endocrinology & Metabolism, Volume 28, Issue 12, 1 December 1968, Pages 1840–1842, https://doi.org/10.1210/jcem-28-12-1840 Published: 01 December 1968 Article history Received: 19 July 1968 Accepted: 05 September 1968 Published: 01 December 1968
ChemInform Abstract: The Tertiary Organometallic Reagent Promoted Reductive Coupling of Aryl Halides (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Evaluating Multi-Radar, Multi-Sensor Products for Surface Hailfall Diagnosis (2021)

The operational deployment of the multi-radar, multi-sensor (MRMS) system has made available new products to use for hail detection. MRMS products are provided on a spatial grid and can give information on hail size and the spatial extent and distribution of the hail fall. This information is important to a wide audience, including warning forecasters needing to focus on areas for warning verification and insurance users needing to verify a claim. Products are typically verified and evaluated using hail reports from Storm Data, which are reports collected by local National Weather Service Offices. The National Severe Storms Laboratory conducted a project to collect reports of hail, including reports of “no hail” near storms, at high spatial resolution. This project, the Severe Hazards Analysis and Verification Experiment (SHAVE), collected tens of thousands of hail reports over ten years of operations. Three-hundred eighty-nine SHAVE operations, which yielded 21 184 SHAVE reports and 2814 Storm Data reports, are investigated. Nine MRMS products were evaluated with the reflectivity at lowest altitude demonstrating the best discrimination for where hail of any size fell and the maximum expected size of hail product provided the best discrimination for severe-sized hail. SHAVE- and Storm Data-based evaluations showed marked differences in product skill scores. Discussions on the differences between the hail report databases and explorations of vertical profiles of reflectivity are included.
Dentin Matrix Protein 1, a Target Molecule for Cbfa1 in Bone, Is a Unique Bone Marker Gene (2002)

Dentin matrix protein 1 (Dmp1), a phosphoprotein highly linked to dentin formation, has also been reported to be expressed in the skeleton. However, the role of Dmp1 in skeletal tissues remains unclear. To clarify the role of Dmp1 in bone formation, we characterized the expression profile of Dmp1 in bone and cartilage and examined whether Dmp1 expression was regulated by core-binding factor a1 (Cbfa1). Studies of fetal rat calvarial (FRC) cell cultures showed that the expression of Dmp1 was associated closely with "bone nodule" formation and mineralization in vitro. In situ hybridization studies were performed to examine the spatial and temporal expression patterns of Dmp1 during development in mouse embryos from 12.5 day postcoitus (dpc) to 8 weeks postnatal; these studies showed that Dmp1 first appeared in hypertrophic cartilage cells, followed by osteoblasts, and later was expressed strongly in osteocytes. The expression profiles of Cbfa1 and Dmp1 overlapped in both cartilage and bone during development, with Cbfa1 preceding Dmp1. Examination of Dmp1 expression in Cbfa1-/- mice revealed that Dmp1 was absent in the developing bones of Cbfa1-null mice, whereas there was essentially no change in Dmp1 expression in the arrested tooth bud. Transient transfection studies showed forced expression of Dmp1 under the control of Cbfa1 and gel shift data indicated the presence of a functional osteocalcin-specific element (OSE)-2 response element in the Dmp1 proximal promoter region. However, in vitro promoter studies suggested that regulation of Dmp1 by Cbfa1 was not mediated by direct binding of Cbfa1 to this site and may be through indirect mechanisms. These studies highlight Dmp1 as a unique marker gene for osteoblastic differentiation. The close association of Dmp1 and Cbfa1 in the developing skeleton suggests that Dmp1 may play an important role in bone formation.
The Jewish Merchant-Colony in Madras (Fort St. George) during the 17th and 18th Centuries: A Contribution to the Economic and Social History of the Jews in India (Concluded) (1960)

Walter J. Fischel, The Jewish Merchant-Colony in Madras (Fort St. George) during the 17th and 18th Centuries: A Contribution to the Economic and Social History of the Jews in India (Concluded), Journal of the Economic and Social History of the Orient, Vol. 3, No. 2 (Aug., 1960), pp. 175-195
Role of monosubstitution product in the reactions of m-dihalobenzenes with diethyl phosphite ion to form tetraethyl m-phenylenebisphosphonate. Strong evidence of mechanism from simple observations (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRole of monosubstitution product in the reactions of m-dihalobenzenes with diethyl phosphite ion to form tetraethyl m-phenylenebisphosphonate. Strong evidence of mechanism from simple observationsJoseph F. Bunnett and Sheldon J. ShaferCite this: J. Org. Chem. 1978, 43, 10, 1873–1877Publication Date (Print):May 1, 1978Publication History Published online1 May 2002Published inissue 1 May 1978https://doi.org/10.1021/jo00404a005RIGHTS & PERMISSIONSArticle Views133Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (656 KB) Get e-Alerts Get e-Alerts
Amino Acid Requirements for Growth of Avian Lung Cultures. (1960)

Primary chick embryo and maturing cockerel lung cultures were found to grow in a test medium containing dialyzed chick embryo extract, bovine serum, and a variety of small molecular constituents. The avian cultures required the 13 amino acids usually found to be essential for mammalian cells. They also were markedly stimulated by glycine or L-serine and by small quantities of L-alanine. Folinic acid and higher levels of folic acid partially replaced the glycine requirement for optimal growth. Pyruvate, oxalacetate, or alpha-ketoglutarate, replaced the requirement for L-alanine. Pyridoxal phosphate partially replaced the L-alanine.
Adaptive receiver algorithms for near-far resistant CDMA (1995)

Adaptive receiver algorithms are considered for the demodulation of code-division multiple-access (CDMA) signals. These algorithms include neural-network based algorithms and algorithms adapted from linear channel equalization techniques. Convergence issues are treated, and the performance of various algorithms is compared via computer simulations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Experimental loss-tolerant quantum coin flipping (2011)

Coin flipping is a cryptographic primitive in which two distrustful parties wish to generate a random bit to choose between two alternatives. This task is impossible to realize when it relies solely on the asynchronous exchange of classical bits: one dishonest player has complete control over the final outcome. It is only when coin flipping is supplemented with quantum communication that this problem can be alleviated, although partial bias remains. Unfortunately, practical systems are subject to loss of quantum data, which allows a cheater to force a bias that is complete or arbitrarily close to complete in all previous protocols and implementations. Here we report on the first experimental demonstration of a quantum coin-flipping protocol for which loss cannot be exploited to cheat better. By eliminating the problem of loss, which is unavoidable in any realistic setting, quantum coin flipping takes a significant step towards real-world applications of quantum communication.
Interleukin–10 Expression and Function in Experimental Murine Liver Inflammation and Fibrosis (1998)

Kupffer cells (KC) play a central role in the initiation and perpetuation of hepatic inflammation, which, if uncontrolled, can result in tissue damage, fibrosis, and cirrhosis. Interleukin-10 (IL-10) can inhibit a range of macrophage functions. We hypothesized that the transcription, synthesis, and release of IL-10 may influence the development of liver injury. Rat KC were activated in vitro with lipopolysaccharide (LPS), and expression of IL-10 mRNA compared with IL-13 and IL-1beta by reverse-transcription polymerase chain reaction (RT-PCR). The effects of pretreatment with recombinant IL-10 (rIL-10) on KC phagocytosis, production of superoxide (SO), and tumor necrosis factor (TNF-) were examined by fluorescent activated cell sorter (FACS), reduction of ferricytochrome C, and bioassay, respectively. Rats were administered intraperitoneal carbon tetrachloride (CCl4), and expression of IL-10 mRNA and protein in vivo compared with IL-13 and IL-1beta by RT-PCR and immunoblotting. Results were correlated with histological inflammatory changes. Finally, IL-10 gene-deleted (IL-10-/-) mice and wild-type (WT) controls were administered intraperitoneal CCl4 biweekly for up to 70 days, and the development of inflammation and fibrosis compared by scoring histological changes. IL-10 mRNA was up-regulated early, both in KC in vitro and in whole liver in vivo, concurrent with that of IL-1beta. IL-10 was able to inhibit KC production of both SO and TNF- in vitro, and this was achieved more effectively than IL-4 or IL-13; no such effects were seen on KC phagocytosis. After 70 days of treatment with CCl4, IL-10-/- mice showed significantly more severe fibrosis and exhibited higher hepatic TNF- levels than WT controls. These results suggest that IL-10 synthesized during the course of liver inflammation and fibrosis may modulate KC actions, and influence subsequent progression of fibrosis.
Concurrent Design to Manufacturing Collaboration for Tooling Industry (2005)

PROCEEDINGS PAPER Concurrent Design to Manufacturing Collaboration for Tooling Industry X. G. Ming, X. G. Ming Shanghai Jiao Tong University, Shanghai, China Search for other works by this author on: This Site PubMed Google Scholar W. F. Lu, W. F. Lu Singapore Institute of Manufacturing Technology, Singapore Search for other works by this author on: This Site PubMed Google Scholar J. Q. Yan, J. Q. Yan Shanghai Jiao Tong University, Shanghai, China Search for other works by this author on: This Site PubMed Google Scholar D. Z. Ma D. Z. Ma Shanghai Jiao Tong University, Shanghai, China Search for other works by this author on: This Site PubMed Google Scholar Author Information X. G. Ming Shanghai Jiao Tong University, Shanghai, China W. F. Lu Singapore Institute of Manufacturing Technology, Singapore J. Q. Yan Shanghai Jiao Tong University, Shanghai, China D. Z. Ma Shanghai Jiao Tong University, Shanghai, China Paper No: DETC2005-85174, pp. 421-429; 9 pages https://doi.org/10.1115/DETC2005-85174 Published Online: June 11, 2008
Hybrid Parallel Light-Weight Programming of Hybrid Systems (2012)

The advent of homogeneous many-core processors has been widely noticed as a major shift in the architecture of commodity computer systems. It has influenced the design of operating systems and programming models and give s a boost to high-level parallelization libraries. Future commodity systems will combine homogeneous many-core processors with graphical processing units and other special purpose accelerators to a new class of architecture called hybrid system. These systems provide improved hardware support for specialized computational tasks of different applications. In contrast to the programming for homogeneous architectures with existing tools, programming for such hybrid architectures is still in its infancy. Today, the software development for such systems explicitly has to address vendor-specific and version-specific characteristics of the particular devices. Due to this, refactoring of existing code becomes a tedious and error-prone task. We present our approach for automatically transforming high-level parallel code written in .NET to parallel code suitable for direct execution on hybrid systems. Our approach relies on the transformation of .NET byte code to an accelerator-aware version, which makes the concept applicable to all .NET-supported programming languages. Hybrid system hardware is targeted by the generation of accelerator-neutral intermediate code, which makes our approach applicable for a wider class of accelerator types. We show the feasibility of our solution with a workload that consists of well-known and widely accepted compute-intense algorithmic problems.
The geometric factor of electrostatic plasma analyzers: A case study from the Fast Plasma Investigation for the Magnetospheric Multiscale mission (2012)

We report our findings comparing the geometric factor (GF) as determined from simulations and laboratory measurements of the new Dual Electron Spectrometer (DES) being developed at NASA Goddard Space Flight Center as part of the Fast Plasma Investigation on NASA's Magnetospheric Multiscale mission. Particle simulations are increasingly playing an essential role in the design and calibration of electrostatic analyzers, facilitating the identification and mitigation of the many sources of systematic error present in laboratory calibration. While equations for laboratory measurement of the GF have been described in the literature, these are not directly applicable to simulation since the two are carried out under substantially different assumptions and conditions, making direct comparison very challenging. Starting from first principles, we derive generalized expressions for the determination of the GF in simulation and laboratory, and discuss how we have estimated errors in both cases. Finally, we apply these equations to the new DES instrument and show that the results agree within errors. Thus we show that the techniques presented here will produce consistent results between laboratory and simulation, and present the first description of the performance of the new DES instrument in the literature.