gebhart/patrepeval huggingface dataset:
Abstract A249: Navitoclax and veliparib yield cytotoxicity with lower doses than used for single agents in women's cancers. (2013)

Abstract Background: The apoptosis inhibitor Bcl-XL is upregulated in recurrent ovarian (Ov) and breast (Br) cancer(Ca)s. Modest clinical activity with navitoclax, Bcl-2, Bcl-XL inhibitor, was observed in hematologic malignancies, although a significant grade 3/4 thrombocytopenia has been a challenge for the further development of navitoclax. Our phase I/Ib study of olaparib (PARP inhibitor) and carboplatin (NCT00647062) in Ov and BrCa patients with BRCA1/2 mutation showed a change in Bim and Bcl-2 tissue protein quantities measured before and after 1 cycle correlated with the duration of response (r2=-0.86, p=0.007). We hypothesized combination of PARP inhibitor, veliparib, with navitoclax will yield clinical synergy at doses lower than used for single agents in women's cancers, thus with the potential to minimize the thrombocytopenia. Materials and Method: We have examined cell injury in Ov (SKOV3, OVCAR8) and triple negative breast cancer (MDA-MB231) cell lines. Cell injury was measured with XTT assays. The clinically attainable dosage of navitoclax and veliparib were compared to the IC50 and a physiologically attainable dose was obtained. Protein expression of Bcl-2, Bcl-XL, Mcl-1, an anti-apoptotic protein of the Bcl-2 family, BAG3, a chaperone protein stabilizing and preventing degradation of Mcl-1 were examined using immunoblot to identify potential biomarkers. Results: Veliparib (up to 50uM) had little single agent activity, up to 11% inhibition of control growth in all cell lines; navitoclax also had limited single agent activity in doses attainable clinically, up to 31% inhibition of control growth at 5uM. Concurrent administration of the two agents yielded a dose dependent increase in cell injury in all cell lines (up to 49% inhibition; p&amp;lt;0.05). Protein expression of Bcl-2 and Bcl-XL was reduced by navitoclax and combination of navitoclax and veliparib showed further reduction in all cell lines. Mcl-1 protein expression was reduced by the combination in all cell lines, although BAG3 was reduced by the combination, only in SKOV3. Further analysis of protein expression, drug effects in soft agar density-independent cultures, and survival assays are in progress in other Br and OvCa cell lines. Conclusions: These preliminary results suggest that the combination of PARP inhibition and Bcl2/Bcl-XL neutralization may be cooperative in yielding better results than either agent alone. Further studies are ongoing to complete credentialing this novel drug combination. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):A249. Citation Format: Jung-Min Lee, Alyssa Stacy, Minshu Yu, Elise C. Kohn. Navitoclax and veliparib yield cytotoxicity with lower doses than used for single agents in women's cancers. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr A249.
Survey and Challenges of QoE Management Issues in Wireless Networks (2013)

With the move towards converged all-IP wireless network environments, managing end-user Quality of Experience (QoE) poses a challenging task, aimed at meeting high user expectations and requirements regarding reliable and cost-effective communication, access to any service, anytime and anywhere, and across multiple operator domains. In this paper, we give a survey of state-of-the-art research activities addressing the field of QoE management, focusing in particular on the domain of wireless networks and addressing three management aspects: QoE modeling, monitoring and measurement, and adaptation and optimization. Furthermore, we identify and discuss the key aspects and challenges that need to be considered when conducting research in this area.
<title>Deconvolution of adaptive optics images: from theory to practice</title> (2000)

Practical guidelines are proposed for deconvolution of partially adaptive optics corrected images: from raw data to high photometric precision object restoration. Preliminary processing is discussed (detector calibration, background subtraction...). The deconvolution scheme itself is then presented. It takes into account the noise statistics in the image, the imprecise knowledge of the point spread function (PSF), and the available a priori information on the object (spatial structure, positivity...). This deconvolution scheme is first validated on simulated images of NAOS, the AO system of the VLT and then applied to astronomical images. In particular, an edge preserving regularization is tested on several solar system objects: Io, Uranus and Neptune.
Analysis of performance regression testing data by transaction profiles (2013)

Performance regression testing is an important step in the software development lifecycle, especially for enterprise applications. Commonly the analysis of performance regression testing to find anomalies is carried out manually and therefore can be error-prone, time consuming and sensitive to the input load. In our research, we propose a new technique that overcomes the above problems which helps the performance testing teams to improve their process and speeds up the entire software production process.
Corrosion resistance of alumina-magnesia castable to slag in steel ladle lining (2011)

The corrosion resistance of alumina-magnesia castable to a basic slag was evaluated to find the highly-resistive castable composition for steel processing. Stable solid phases were CA6, alumina and spinel after firing of the castable of Al2O3–MgO–CaO–SiO2 system. The slag corrosion was simulated thermodynamically for CA6, alumina, spinel and castables. The solubility of each oxide component is expected in the order of MgAl2O4 > CA6 > Al2O3 at 1600°C because of the formation of CA2 on CA6 and the formation of CA2 and CA6 on alumina, suggesting the protection of castable from slag. However, CA2 and CA6 disappear at 1800°C and the solubility changes in the order of CA6 > Al2O3 > MgAl2O4. Although the protection of castable by CA6 is also expected, the CA6 disappears at a large amount of slag and a high temperature. The solubility of castable decreases with increasing MgO/CaO ratio owing to spinel formation. The practical immersion test demonstrated the high corrosion resistance of high MgO/CaO castable against slag, exhibiting the importance of spinel formation.
Characterization and quantification of mRNA transcripts in ejaculated spermatozoa of fertile men by serial analysis of gene expression (2006)

A SAGE analysis of ejaculate from fertile men has revealed a large number of transcripts, which occur in steady frequencies and probably have important roles in spermatogenesis and fertilization.
Introduction to Computer Vision and OpenCV (2013)

A significant share of the information that we get from the world while we are awake is through sight. Our eyes do a wonderful job of swiveling about incessantly and changing focus as needed to see things. Our brain does an even more wonderful job of processing the information stream from both eyes and creating a 3D map of the world around us and making us aware of our position and orientation in this map. Wouldn't it be cool if robots (and computers in general) could see, and understand what they see, as we do?
Head pose estimation using stereo vision for human-robot interaction (2004)

We present a method for estimating a person's head pose with a stereo camera. Our approach focuses on the application of human-robot interaction, where people may be further away from the camera and move freely around in a room. We show that depth information acquired from a stereo camera not only helps improving the accuracy of the pose estimation, but also improves the robustness of the system when the lighting conditions change. The estimation is based on neural networks, which are trained to compute the head pose from grayscale and disparity images of the stereo camera. It can handle pan and tilt rotations from -90/spl deg/ to +90/spl deg/. Our system does not require any manual initialization and does not suffer from drift during an image sequence. Moreover the system is capable of real-time processing.
Primary hepatocellular carcinoma and metabolic syndrome: An update (2013)

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. The incidence of hepatocellular carcinoma has increased dramatically by 80% over the past two decades in the United States. Numerous basic science and clinical studies have documented a strong association between hepatocellular carcinoma and the metabolic syndrome. These studies have documented that, in most patients, non-alcoholic fatty liver disease is the hepatic manifestation of the metabolic syndrome, which may progress to hepatocellular carcinoma through the cirrhotic process. However, minority of patients with non-alcoholic fatty liver disease may progress to hepatocellular carcinoma without cirrhosis. This review summarizes the current literature of the link between hepatocellular carcinoma and metabolic syndrome with special emphasis on various components of the metabolic syndrome including risk of association with obesity, diabetes mellitus, hyperlipidemia, and hypertension. Current understanding of pathophysiology, clinical features, treatments, outcomes, and surveillance of hepatocellular carcinoma in the background of metabolic syndrome and non-alcoholic fatty liver disease is reviewed. With the current epidemic of metabolic syndrome, the number of patients with non-alcoholic fatty liver disease is increasing. Subsequently, it is expected that the incidence and prevalence of HCC will also increase. It is very important for the scientific community to shed more light on the pathogenesis of HCC with metabolic syndrome, both with and without cirrhosis. At the same time it is also important to quantify the risk of hepatocellular carcinoma associated with the metabolic syndrome in a prospective setting and develop surveillance recommendations for detection of hepatocellular carcinoma in patients with metabolic syndrome.
Genetic regulation of delayed-type hypersensitivity responses to poly(LTyr,LGlu)-poly(DLAla)--poly(LLys). II. Evidence for a T-T-cell collaboration in delayed-type hypersensitivity responses and for a T-cell defect at the efferent phase in nonresponder H-2k mice. (1980)

The intercellular interactions and the site of the genetic defect in delayed-type hypersensitivity (DTH) response to poly(LTyr,LGlu)-poly(DLAla)--poly(LLys) [(T,G)-A--L] has been studied in a system where the T-cell education phase was separated from the efferent phase. In the cellular response, T-T-cell collaboration is required, because T cell-depleted mice were unable to manifest DTH responses after they were transferred with educated and irradiated T cells. Reconstitution of adult thymectomized mice that were irradiated and supplemented with bone marrow cells after treatment with anti-Thy-1.2 serum and complement, with T cells but not with accessory cells gave rise to significant responses. Educated, radioresistant cells required the presence of normal radiosensitive T cells for successful DTH responses to (T,G)-A--L. The genetic defect of nonresponder H-2k and H-2a mice has been located in the above-mentioned, second T-cell population that participates in the efferent phase of this immune reaction. Further characterization revealed that the educated cells are of the Lyt1+ phenotype and that the second normal T cells are expressing the Lyt 1+,2+,3+ phenotype. Thus, the genetic defect of H-2k and H-2a mice in the DTH response to (T,G)-A--L is expressed on the non-antigen-stimulated Lyt 1+,2+,3+ T cells.
[Winter skin diseases]. (1999)

Winter climate is prone to induce cutaneous and systemic alterations mediated by cold. Xerosis due to the impairment of the desquamation process is not rare on the limbs. Chilbain results from reversible alterations of the dermal vasculature. Cold panniculitis is the consequence of lipid crystallization within adipocytes. More dramatic issues occur when cold exposure extends beyond skin. They are represented by frostbite and body hypothermia. Intensity and duration of cold exposure combined with wind speed, altitude and environmental hygrometric value govern the potential type of low temperature-dependent pathology. Ultraviolet irradiation can also induce cutaneous lesions during winter time.
Carbon-carbon bond formation promoted by transition metal carbonyls. 16. Reaction of .alpha.,.alpha.'-dibromo ketones and iron carbonyls. Mechanistic aspects (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-carbon bond formation promoted by transition metal carbonyls. 16. Reaction of .alpha.,.alpha.'-dibromo ketones and iron carbonyls. Mechanistic aspectsR. Noyori, Y. Hayakawa, H. Takaya, S. Murai, R. Kobayashi, and N. SonodaCite this: J. Am. Chem. Soc. 1978, 100, 6, 1759–1765Publication Date (Print):March 1, 1978Publication History Published online1 May 2002Published inissue 1 March 1978https://pubs.acs.org/doi/10.1021/ja00474a018https://doi.org/10.1021/ja00474a018research-articleACS PublicationsRequest reuse permissionsArticle Views365Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
32nm 1-D regular pitch SRAM bitcell design for interference-assisted lithography (2008)

As optical lithography advances into the 45nm technology node and beyond, new manufacturing-aware design requirements have emerged. We address layout design for interference-assisted lithography (IAL), a double exposure method that combines maskless interference lithography (IL) and projection lithography (PL); cf. hybrid optical maskless lithography (HOMA) in [2] and [3]. Since IL can generate dense but regular pitch patterns, a key challenge to deployment of IAL is the conversion of existing designs to regular-linewidth, regular-pitch layouts. In this paper, we propose new 1-D regular pitch SRAM bitcell layouts which are amenable to IAL. We evaluate the feasibility of our bitcell designs via lithography simulations and circuit simulations, and confirm that the proposed bitcells can be successfully printed by IAL and that their electrical characteristics are comparable to those of existing bitcells.
Extremely foldable LTPS TFT backplane using blue laser annealing for low‐cost manufacturing of rollable and foldable AMOLED display (2021)

Abstract The crystallization of a‐Si by blue laser annealing (BLA) is introduced for low‐cost, high‐resolution thin‐film transistor (TFT) backplanes for foldable and rollable AMOLED displays. A big advantage of BLA is to provide low‐temperature polycrystalline silicon (LTPS) with protrusion‐free active channel. The BLA LTPS TFT manufactured on flexible substrate exhibits high field‐effect mobility of 169 cm 2 /Vs, a smaller subthreshold voltage swing less than 201 mV/dec, and excellent electrical stability and mechanical robustness.
Semiglobally strictly passive two-port network representation of rigid link manipulator under PID trajectory-tracking control (2010)

This paper presents a mathematical representation of a system composed of a rigid link manipulator under PID trajectory-tracking control. The representation describes the system as a two-port network that accepts the external force (including the gravity) and the desired velocity as the inputs and produces the actuator force and a motion-related quantity as the outputs. The input-output causality between the desired velocity and the actuator force is reversible by exploiting the fact that they are connected through a feedthrough term. The model is shown to be state-strictly and output-strictly passive in the semiglobal sense by using a storage function suggested by Wen and Murphy [1990] as a Lyapunov function for a PID-controlled robot. The new model allows the analysis of a class of controllers that are represented as an interconnection of a PID controller and another controller such as a sliding mode controller. In addition, it leads to an alternative proof for the semiglobal stability of PID set-point control.
Enhancement of chemotherapy by manipulation of tumour pH (1999)

The extracellular (interstitial) pH (pHe) of solid tumours is significantly more acidic compared to normal tissues. In-vitro, low pH reduces the uptake of weakly basic chemotherapeutic drugs and, hence, reduces their cytotoxicity. This phenomenon has been postulated to contribute to a 'physiological' resistance to weakly basic drugs in vivo. Doxorubicin is a weak base chemotherapeutic agent that is commonly used in combination chemotherapy to clinically treat breast cancers. This report demonstrates that MCF-7 human breast cancer cells in vitro are more susceptible to doxorubicin toxicity at pH 7.4, compared to pH 6.8. Furthermore 31P-magnetic resonance spectroscopy (MRS) has shown that the pHe of MCF-7 human breast cancer xenografts can be effectively and significantly raised with sodium bicarbonate in drinking water. The bicarbonate-induced extracellular alkalinization leads to significant improvements in the therapeutic effectiveness of doxorubicin against MCF-7 xenografts in vivo. Although physiological resistance to weakly basic chemotherapeutics is well-documented in vitro and in theory, these data represent the first in vivo demonstration of this important phenomenon.
[Collagenase and Related Matrix Metalloproteinases - a Prominent Role in the Initiation of Menstruation] (1995)

The human endometrium shows striking structural changes during the menstrual cycle. If no pregnancy develops, the fall of plasma progesterone and estradiol induces extracellular matrix degradation leading to haemorrhagia and mucosal shedding, i. e. menstruation. The mechanisms of endome trial tissue breakdown remain obscure. A major role of lysosomal hydrolases is not supported by biochemical evidence, whereas recent studies by several laboratories including our own suggest that interstitial collagenase and related matrix metalloproteinases (MMPs) are involved. We have demonstrated that human endometrium in tissue culture can produce interstitial collagenase and gelatinases A and B. Both the expression and the activation of these MMPs were inhibited by physiological concentrations of progesterone and estradiol. Moreover, in fresh human endometrial tissue, expression of mRNA, protein and activity of interstitial collagenase, as well as of mRNA of several other MMPs is limited to the perimenstrual period. In such tissues, immunolocalisation and in situ hybridization show that the expression is focal. The tight hormonal control as well as the restricted temporal and spatial expression of MMPs in human endometrium all point to a pivotal role of interstitial collagenase and other MMPs in the initiation of menstruation.
Effect of a 6-fluoro substituent on the metabolism and biological activity of benzo(a)pyrene. (1983)

Cytochrome P-450-catalyzed epoxidation of (-)-(7 R ,8 R )-dihydroxy-7,8-dihydrobenzo( a )pyrene to (+)-(7 R ,8 S )-dihydroxy-(9 S ,10 R )-epoxy-7,8,9,10-tetrahydrobenzo( a )pyrene is now well recognized as the primary pathway by which benzo( a )pyrene is converted to an ultimate carcinogen. The present metabolism studies of 6-fluorobenzo( a )pyrene indicate ( a ) that the 6-fluoro substituent does not dramatically block the formation of quinones involving position 6 and ( b ) that substantially more (∼2-fold) of the 7,8-dihydrodiol is formed from 6-fluorobenzo( a )pyrene than is formed from benzo( a )pyrene. As is the case for benzo( a )pyrene, the 6-fluoro-7,8-dihydrodiol was found to be of high optical purity and has (7 R ,8 R )absolute configuration. Electrostatic repulsion appears to cause the fluorinated 4,5- as well as 7,8-dihydrodiols to prefer the pseudodiaxial rather than the pseudodiequatorial conformation observed for these dihydrodiols when formed from benzo( a )pyrene. Comparision of the tumor-initiating activities of benzo( a )pyrene and 6-fluorobenzo( a )pyrene on the skin of female Sencar mice indicates that the fluorinated hydrocarbon is far less active in the initiation of tumors. In addition, the metabolites of the fluorinated 7,8-dihydrodiol do not display strong mutagenic activity toward Chinese hamster V79 cells. Altered conformation of the fluorinated 7,8-dihydrodiol and the resultant 7,8-diol-9,10-epoxide diastereomer in which the benzylic 7-hydroxyl group and the epoxide oxygen are trans provides a plausible explanation for the weak tumorigenicity of 6-fluorobenzo( a )pyrene on mouse skin, since all benzo-ring dihydrodiols and diol-epoxides in which the hydroxyl groups prefer the pseudodiaxial conformation are weak or inactive as carcinogens. In formulating the bay-region theory, we had pointed out that perifluorine substituents such as at position 6 in benzo( a )pyrene have a marked inhibitory effect on the tumorigenicity of the hydrocarbon. The present results provide a basis for this “perieffect.”
Clinical and pathological characterization of ophthalmic disease in a canine model of mucopolysaccharidosis type I (2023)

Mucopolysaccharidosis type I (MPS I) is a rare lysosomal storage disease caused by α-L-iduronidase enzyme deficiency, resulting in glycosaminoglycan (GAG) accumulation in various cell types, including ocular tissues. Ocular manifestations in humans are common with significant pathological changes including corneal opacification, retinopathy, optic nerve swelling and atrophy, and glaucoma. Available treatments for MPS I are suboptimal and there is limited to no effect in treating the ocular disease. The goal of this study was to characterize the clinical and pathological features of ocular disease in a line of MPS I affected dogs, including changes not previously reported. A total of 22 dogs were studied; 12 MPS I were affected and 10 were unaffected. A subset of each underwent complete ophthalmic examination including slit lamp biomicroscopy, indirect ophthalmoscopy, rebound tonometry, and ultrasonic pachymetry. Globes were evaluated microscopically for morphological changes and GAG accumulation. Clinical corneal abnormalities in affected dogs included edema, neovascularization, fibrosis, and marked stromal thickening. Intraocular pressures were within reference interval for affected and unaffected dogs. Microscopically, vacuolated cells containing alcian blue positive inclusions were detected within the corneal stroma, iris, ciliary body, sclera, and optic nerve meninges of affected dogs. Ganglioside accumulation was identified by luxol fast blue staining in rare retinal ganglion cells. Increased lysosomal integral membrane protein-2 expression was demonstrated within the retina of affected animals when compared to unaffected controls. Results of this study further characterize ocular pathology in the canine model of MPS I and provide foundational data for future therapeutic efficacy studies.