gebhart/patrepeval huggingface dataset:
Melatonin Suppression of Mammary Growth in Heifers1 (1991)

The objective of this study was to determine if melatonin fed in the middle of a long day (16L:8D) reduces mammary parenchymal growth and reduces serum prolactin in prepubertal heifers, thereby mimicking the effects of a short photoperiod. Sixteen prepubertal Holstein heifers were maintained under natural May to August environmental conditions of Michigan plus supplemental lighting to provide a photoperiod of 16L:8D (lights-on 0600-2200 h). At the midpoint of each day, 8 animals were individually fed melatonin (4 mg/100 kg body weight) and 8 were individually fed vehicle (95% ethanol) in 200 g of a grain concentrate mixture. Blood samples were collected at 1-h intervals for 25 h beginning on Day 67. On Day 70 or 72 heifers were slaughtered. No differences were found in body weight gain between melatonin- and vehicle-fed animals. Parenchyma of mammary glands from melatonin-fed heifers had a lower content (24%) and concentration (17%) of deoxyribonucleic acid but a greater concentration of triglyceride (24%) than that of controls. Mean serum prolactin concentration was 27% lower in melatonin-fed animals. In both groups, serum concentrations of prolactin varied throughout the day, with greatest values occurring between 1100 and 1800 h in positive association with changes in ambient temperature. We conclude that melatonin orally administered to prepubertal heifers reduced mammary parenchymal growth and concentration of prolactin in serum. The data support the hypothesis that melatonin mimics photoperiodic effects on mammary growth and prolactin secretion in cattle.
The Kinematics of Treadmill Locomotion in Space (1997)

Locomotion on a treadmill in 0 G will probably remain a centerpiece of NASA's exercise countermeasures programme. This form of physical activity has the potential to cause large bone and muscle forces as well as loading during a period of continuous treadmill exercise. A critical concern is the provision of a treadmill which can approximate 1 G performance in space. At this point, no adequate objective measurements of in-flight treadmill kinetics or of the human response to this activity have been made. Interpretation of the results obtained in the present study is limited by the following: (1) bungee tensions were not measured; (2) ground reaction forces were not measured in parallel with the kinematic measurements; and (3) the instrumentation used to film the astronauts could itself have been affected by microgravity. Despite these shortcomings, what is apparent is that exercise during NASA missions STS 7 and STS 8 resulted in leg motions that were similar to those found during 1 G locomotion on an inclined passive treadmill and on an active treadmill at an even steeper grade. In addition, it was apparent that the majority of the loads were transmitted through the forefoot, and one can surmise that this style of running would result in physiologically significant tensions in the calf musculature and resultant ankle compressive loading. Further speculation regarding limb loading is complicated by the fact that varying amounts of force are transmitted through (1) the treadmill handle and (2) bungee cords that act as a tether. New generations of treadmills are being manufactured that could provide I important information for planners of long-duration space missions. If these types of treadmill are flown on future missions, it will be possible to control bungee tensions more precisely, control for grade and speed, and, most importantly, provide data on the rates and magnitudes of limb loading. These data could then be incorporated into biomechanical models of the lower limb to more fully understand mechanisms of load transmission from distal to proximal structures and to optimize in-flight exercise protocols in such a way that muscle and bone loss could be reduced.
Synthesis of Tetrapeptides Containing Dehydroalanine, Dehydrophenylalanine and Oxazole as Building Blocks for Construction of Foldamers and Bioinspired Catalysts (2022)

The incorporation of dehydroamino acid or fragments of oxazole into peptide chain is accompanied by a distorted three-dimensional structure and additionally enables the introduction of non-typical side-chain substituents. Thus, such compounds could be building blocks for obtaining novel foldamers and/or artificial enzymes (artzymes). In this paper, effective synthetic procedures leading to such building blocks-tetrapeptides containing glycyldehydroalanine, glycyldehydrophenylalanine, and glycyloxazole subunits-are described. Peptides containing serine were used as substrates for their conversion into peptides containing dehydroalanine and aminomethyloxazole-4-carboxylic acid while considering possible requirements for the introduction of these fragments into long-chain peptides at the last steps of synthesis.
A spatio-temporal competing scheme for the rate-distortion optimized selection and coding of motion vectors (2006)

The recent H.264/MPEG4-AVC video coding standard has achieved a significant bitrate reduction compared to its pre-decessors. High performance texture coding tools and 14-pel motion accuracy have however contributed to an increased proportion of bits dedicated to the motion information. The future ITU-T challenge, to provide a codec with 50 % bitrate reduction compared to the current H.264, may result in even more accurate motion models. It is consequently of highest interest to reduce the motion information cost. This paper proposes a competitive framework, with spa-tial and temporal predictors optimally selected by a rate-distortion criterion taking into account the cost of the motion vector and the predictor information. These new methods take benefit of temporal redundancies in the motion field, where the standard spatial median usually fails. Compared to an H.264/MPEG4-AVC standard codec, a systematic bi-trate saving reaching up to 20 % for complex sequences is reported.
A high probability bound on the mutual information across an observed Discrete Memoryless Channel (2015)

This paper introduces several new high probability bounds on the average mutual information, I (X; Y ) between the input and output of a Discrete Memoryless Channel (DMC) based on a set of observed input-output samples. We assume that channel-input probability mass function and channel transition probability mass functions are unknown. We compare a Bayesian-Dirichlet distribution model against a computationally-tractable distribution-free high-probability bound to determine (1) the rate of information possibly flowing across the channel and (2) the rate information could flow across the channel. The performance (as a function of N, the number of observed samples) is compared via simulation. The rate of convergence is towards to 'true' mutual information rate shown to be O (log(N)/N).
Preparing High Purity Initial States for Nuclear Magnetic Resonance Quantum Computing (2004)

Here we demonstrate how parahydrogen can be used to prepare a two-spin system in an almost pure state which is suitable for implementing nuclear magnetic resonance quantum computation. A 12 ns laser pulse is used to initiate a chemical reaction involving pure parahydrogen (the nuclear spin singlet of H2). The product, formed on the micros time scale, contains a hydrogen-derived two-spin system with an effective spin-state purity of 0.916. To achieve a comparable result by direct cooling would require an unmanageable (in the liquid state) temperature of 6.4 mK or an impractical magnetic field of 0.45 MT at room temperature. The resulting spin state has an entanglement of formation of 0.822 and cannot be described by local hidden variable models.
CCQM-P134 Pb isotope amount ratios and delta-values in bronze (2017)

Isotope amount ratios (hereafter referred to as simply isotope ratios) are proving useful in an ever increasing array of applications that range from studies unravelling transport processes, to pinpointing the provenance of specific samples as well as trace element quantification by using isotope dilution mass spectrometry (IDMS). These expanding applications encompass fields as diverse as archaeology, food chemistry, forensic science, geochemistry, medicine and metrology. However, to be effective tools, the isotope ratio data must be reliable and traceable to enable the comparability of measurement.
The importance of traceability and comparability in isotope ratio analysis has already been recognized by the Inorganic Analysis Working Group (IAWG) within the CCQM. Three pilot studies have focused on the quality of isotope ratio determinations (P48 “U isotope ratios in urine”, P75 “stable isotopes in Methionine”, P105 “87Sr/86Sr in wine”). Moreover, isotope ratio measurements are fundamental to IDMS amount of substance determinations. For example, when Pb quantification using IDMS is undertaken, this requires the measurements of Pb isotope ratios. While the requirements for isotope ratio accuracy and precision in the case of of IDMS are generally quite modest, “absolute” Pb isotope ratio measurements for geochemical age dating and source rock characterization as well as forensic provenance and fingerprinting studies require Pb isotope ratio measurements of the highest quality. To support present and future CMCs on isotope ratio determinations, a Key Comparison was urgently needed. Therefore, it was decided at the IAWG meeting in Paris in April 2011 that a Key Comparison on the determination of Pb isotope ratios in a pure Pb solution and in a bronze sample should be organized and accompanied by a pilot study.
Measuring Pb isotope amount ratios in a pure Pb solution, while seemingly straight forward, rigorously tests the ability of analyst to correct for any instrumental effects (such as mass discrimination and blank correction) on the measured ratios. Pb, present in trace amounts in a metal matrix sample (e.g. Pb in bronze), provides a real world test of the whole chemical and instrumental procedure, from chemical separation and sample purification to analysis and subsequent correction of appropriate instrumental effects on the separated samples.
A suitable bronze material with a Pb mass fraction between 10 and 100 mg·kg-1 was available at BAM. A high purity solution of Pb with a mass fraction of approximately 100 mg·kg-1 was also available. By comparing the Pb isotope ratio results obtained for the bronze sample with the Pb isotope ratio results from the Pb solution, potential biases arising from the processing of the bronze sample could be effectively identified and separated from the instrumental effects arising from the measurement and data processing protocol.
cAMP cascade (PKA, Epac, adenylyl cyclase, Gi, and phosphodiesterases) regulates myelin phagocytosis mediated by complement receptor‐3 and scavenger receptor‐AI/II in microglia and macrophages (2005)

The removal by phagocytosis of degenerated myelin is central for repair in Wallerian degeneration that follows traumatic injury to axons and in autoimmune demyelinating diseases (e.g., multiple sclerosis). We tested for roles played by the cAMP cascade in the regulation of myelin phagocytosis mediated by complement receptor-3 (CR3/MAC-1) and scavenger receptor-AI/II (SRAI/II) separately and combined in mouse microglia and macrophages. Components of the cAMP cascade tested are cAMP, adenylyl cyclase (AC), Gi, protein kinase A (PKA), exchange protein directly activated by cAMP (Epac), and phosphodiesterases (PDE). PKA inhibitors H-89 and PKI(14-22) amide inhibited phagocytosis at normal operating cAMP levels (i.e., those occurring in the absence of reagents that alter cAMP levels), suggesting activation of phagocytosis through PKA at normal cAMP levels. Phagocytosis was inhibited by reagents that elevate endogenous cAMP levels to above normal: Gi-inhibitor Pertussis toxin (PTX), AC activator Forskolin, and PDE inhibitors IBMX and Rolipram. Phagocytosis was inhibited also by cAMP analogues whose addition mimics abnormal elevations in endogenous cAMP levels: nonselective 8-bromo-cAMP, PKA-specific 6-Benz-cAMP, and Epac-specific 8-CPT-2'-O-Me-cAMP, suggesting that abnormal high cAMP levels inhibit phagocytosis through PKA and Epac. Altogether, observations suggest a dual role for cAMP and PKA in phagocytosis: activation at normal cAMP levels and inhibition at higher. Furthermore, a balance between Gi-controlled cAMP production by AC and cAMP degradation by PDE maintains normal operating cAMP levels that enable efficient phagocytosis.
ChemInform Abstract: Synthesis and Properties of Br2VS2N3. (1986)

Abstract S 4 N 4 reacts with VBr 3 in CH 2 Br 2 to give the 6‐membered ring compound Br 2 VS 2 N 3 .
Part Detector Discovery in Deep Convolutional Neural Networks (2014)

Current fine-grained classification approaches often rely on a robust localization of object parts to extract localized feature representations suitable for discrimination. However, part localization is a challenging task due to the large variation of appearance and pose. In this paper, we show how pre-trained convolutional neural networks can be used for robust and efficient object part discovery and localization without the necessity to actually train the network on the current dataset. Our approach called "part detector discovery" (PDD) is based on analyzing the gradient maps of the network outputs and finding activation centers spatially related to annotated semantic parts or bounding boxes. This allows us not just to obtain excellent performance on the CUB200-2011 dataset, but in contrast to previous approaches also to perform detection and bird classification jointly without requiring a given bounding box annotation during testing and ground-truth parts during training. The code is available at http://www.inf-cv.uni-jena.de/part_discovery and https://github.com/cvjena/PartDetectorDisovery.
Enhancing the Performance of Integrated Optical Sensor by Slow-light: Theoretical Study on Ring-Resonator Based Structures (2007)

Abstract – In this work, the performance of three kinds of integrated optical ring-resonator based slow-light structures for sensing applications is theoretically studied using the transfer matrix method and the complex transmission coefficient approach. Enhancement of sensing performance due to the slow-light phenomenon is quantitatively formulated. The modeling results show that using realistic structure parameters, a refractive index detection limit of one order better than the state of the art Mach-Zehnder interferometer sensing structure is possible by the inclusion of such a slow-light structure. The role of ring(s) attenuation constant in limiting the usable light slowness and the achievable sensor resolution is also discussed. For a sufficiently small ring attenuation constant, the optimal sensing performance of a single-resonator circuit can be better than that of multiple resonator circuits, while offering less fabrication complexities, cleaner spectra, shorter device length, and higher figure of merit.
GPS performance in navigation (1999)

We discuss Global Positioning System (GPS) measurements available for civil use and algorithms for processing them to obtain real-time estimates of position and velocity. The main objective is to characterize the measurements and to demonstrate the levels of performance achievable with a single GPS receiver and with system augmentations which make corrections to the measurements available to the user in real time. Representative results with positioning accuracy levels ranging from tens of meters to centimeters are given based on actual measurements.
Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes (2021)

Several new synthetic cathinones, which mimic the effect of classical psychostimulants such as cocaine or MDMA, have appeared in the global illicit drug market in the last decades. In fact, the illicit drug market is continually evolving by constantly adding small modifications to the common chemical structure of synthetic cathinones. Thus, the aim of this study was to investigate the <i>in vitro</i> and <i>in vivo</i> structure-activity relationship (SAR) of six novel synthetic cathinones currently popular as recreational drugs, pentedrone, pentylone, N-ethyl-pentedrone (NEPD), N-ethyl-pentylone (NEP), 4-methyl-pentedrone (4-MPD), and 4-methyl-ethylaminopentedrone (4-MeAP), which structurally differ in the absence or presence of different aromatic substituents and in their amino terminal group. Human embryonic kidney (HEK293) cells expressing the human isoforms of SERT and DAT were used for the uptake inhibition and release assays. Moreover, Swiss CD-1 mice were used to investigate the psychostimulant effect, rewarding properties (3, 10, and 30 mg/kg, i.p.), and the induction of immediate-early genes (IEGs), such as <i>Arc</i> and <i>c-fos</i> in the dorsal striatum (DS) and ventral striatum (VS) as well as <i>bdnf</i> in the medial prefrontal cortex (mPFC), of the test compounds. Our results demonstrated that all tested synthetic cathinones are potent dopamine (DA) uptake inhibitors, especially the N-ethyl analogs, while the ring-substituted cathinones tested showed higher potency as SERT inhibitors than their no ring-substituted analogs. Moreover, unlike NEP, the remaining test compounds showed clear "hybrid" properties, acting as DAT blockers but SERT substrates. Regarding the locomotion, NEP and NEPD were more efficacious (10 mg/kg) than their N-methyl analogs, which correlates with their higher potency inhibiting the DAT and an overexpression of <i>Arc</i> levels in the DS and VS. Furthermore, all compounds tested induced an increase in <i>c-fos</i> expression in the DS, except for 4-MPD, the least effective compound in inducing hyperlocomotion. Moreover, NEP induced an up-regulation of <i>bdnf</i> in the mPFC that correlates with its 5-HTergic properties. Finally, the present study demonstrated for the first time that NEP, 4-MPD, and 4-MeAP induce reward in mice. Altogether, this study provides valuable information about the mechanism of action and psychostimulant and rewarding properties as well as changes in the expression of IEGs related to addiction induced by novel second-generation synthetic cathinones.
STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer (2019)

We propose that STAT3 inhibition is a viable and potent therapeutic target against Tregs. Our data support the design of clinical trials integrating STAT3 ASO in the standard of care for cancer patients receiving radiation.
Performance by design (2002)

A calculation method with a modular structure based on a deductive crusher model was developed. Full-scale tests were performed to validate the model and, an agreement was found between the simulated results and the experimental data. The formulation of size-reduction strategies will further improve the fundamental understanding of the size-reduction process.
Mechanical Regulation of Glycogen Synthase Kinase 3β (GSK3β) in Mesenchymal Stem Cells Is Dependent on Akt Protein Serine 473 Phosphorylation via mTORC2 Protein (2020)

Mechanical signals can inactivate glycogen synthase kinase 3β (GSK3β), resulting in stabilization of β-catenin. This signaling cascade is necessary for the inhibition of adipogenesis in mesenchymal stem cells (MSC) that is produced by a daily strain regimen. We investigated whether Akt is the mechanically activated kinase responsible for phosphorylation and inactivation of GSK3β in MSC. Mechanical strain (2% magnitude, 0.17 Hz) induced phosphorylation of Akt at Ser-473 and Thr-308 in parallel with phosphorylation of GSK3β at Ser-9. Inhibiting Akt (Akt1/2 kinase inhibitor treatment or Akt knockdown) prevented strain-induced phosphorylation of GSK3β at Ser-9. Inhibition of PI3K prevented Thr-308 phosphorylation, but strain-induced Ser-473 phosphorylation was measurable and induced phosphorylation of GSK3β, suggesting that Ser-473 phosphorylation is sufficient for the downstream mechanoresponse. As Rictor/mTORC2 (mammalian target of rapamycin complex 2) is known to transduce phosphorylation of Akt at Ser-473 by insulin, we investigated whether it contributes to strain-induced Ser-473 phosphorylation. Phosphorylation of Ser-473 by both mechanical and insulin treatment in MSC was prevented by the mTOR inhibitor KU0063794. When mTORC2 was blocked, mechanical GSK3β inactivation was prevented, whereas insulin inhibition of GSK3β was still measured in the absence of Ser-473 phosphorylation, presumably through phosphorylation of Akt at Thr-308. In sum, mechanical input initiates a signaling cascade that is uniquely dependent on mTORC2 activation and phosphorylation of Akt at Ser-473, an effect sufficient to cause inactivation of GSK3β. Thus, mechanical regulation of GSK3β downstream of Akt is dependent on phosphorylation of Akt at Ser-473 in a manner distinct from that of growth factors. As such, Akt reveals itself to be a pleiotropic signaling molecule whose downstream targets are differentially regulated depending upon the nature of the activating input.
Establishment of T cell lines to bovine beta-casein and beta-casein-derived epitopes in patients with type 1 diabetes (2003)

Enhanced cellular immune response to bovine beta-casein has been reported in patients with type 1 diabetes. In this study we aimed to establish beta-casein-specific T cell lines from newly diagnosed type 1 diabetic patients and to characterise these cell lines in terms of phenotype and epitope specificity. Furthermore, since sequence homologies exist between beta-casein and putative beta-cell autoantigens, reactivity to the latter was also investigated. T cell lines were generated from the peripheral blood of nine recent onset type 1 diabetic patients with different HLA-DQ and -DR genotypes, after stimulation with antigen pulsed autologous irradiated antigen presenting cells (APCs) and recombinant human interleukin-2 (rhIL-2). T cell line reactivity was evaluated in response to bovine beta-casein, to 18 overlapping peptides encompassing the whole sequence of beta-casein and to beta-cell antigens, including the human insulinoma cell line, CM, and a peptide from the beta-cell glucose transporter, GLUT-2. T cell lines specific to beta-casein could not be isolated from HLA-matched and -unmatched control subjects. beta-Casein T cell lines reacted to different sequences of the protein, however a higher frequency of T cell reactivity was observed towards the C-terminal portion (peptides B05-14, and B05-17 in 5/9 and 4/9 T cell lines respectively). Furthermore, we found that 1 out of 9 beta-casein-specific T cell lines reacted also to the homologous peptide from GLUT-2, and that 3 out of 4 of tested cell lines reacted also to extracts of the human insulinoma cell line, CM. We conclude that T cell lines specific to bovine beta-casein can be isolated from the peripheral blood of patients with type 1 diabetes; these cell lines react with multiple and different sequences of the protein particularly towards the C-terminal portion. In addition, reactivity of beta-casein T cell lines to human insulinoma extracts and GLUT-2 peptide was detected, suggesting that the potential cross-reactivity with beta-cell antigens deserves further investigation.
File servers for network-based distributed systems (1984)

article Free Access Share on File servers for network-based distributed systems Author: Liba Svobodova IBM Zurich Research Laboratory, Ruschlikon, Switzerland IBM Zurich Research Laboratory, Ruschlikon, SwitzerlandView Profile Authors Info & Claims ACM Computing SurveysVolume 16Issue 4pp 353–398https://doi.org/10.1145/3872.3873Published:01 December 1984Publication History 85citation2,547DownloadsMetricsTotal Citations85Total Downloads2,547Last 12 Months247Last 6 weeks30 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Publisher SiteeReaderPDF