gebhart/patrepeval huggingface dataset:
Secure and Privacy-Friendly Local Electricity Trading and Billing in\n Smart Grid (2018)

This paper proposes two decentralised, secure and privacy-friendly protocols\nfor local electricity trading and billing, respectively. The trading protocol\nemploys a bidding algorithm based upon secure multiparty computations and\nallows users to trade their excess electricity among themselves. The bid\nselection and calculation of the trading price are performed in a decentralised\nand oblivious manner. The billing protocol is based on a simple\nprivacy-friendly aggregation technique that allows suppliers to compute their\ncustomers' monthly bills without learning their fine-grained electricity\nconsumption data. We also implemented and tested the performance of the trading\nprotocol with realistic data. Our results show that it can be performed for\n2500 bids in less than five minutes in the on-line phase, showing its\nfeasibility for a typical electricity trading period of 30 minutes.\n
Fine-grain parallelism with minimal hardware support: a compiler-controlled threaded abstract machine (1991)

In this paper, we present a relatively primitive execution model for fine-grain parallelism, in which all synchronization, scheduling, and storage management is explicit and under compiler control. This is defined by a threaded abstract machine (TAM) with a multilevel scheduling hierarchy. Considerable temporal locality of logically related threads is demonstrated, providing an avenue for effective register use under quasidynamic scheduling.
Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin, a cancer-associated retinopathy antigen, possibly related with a better prognosis in a paraneoplastic syndrome (2001)

Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome, and the recoverin-specific autoantibody is suggested to contribute to the pathogenesis of retinopathy, including apoptosis of retinal cells. Because it is known that CAR+ cancer patients have a preferable prognosis, we hypothesized that aberrantly expressed recoverin in cancer cells can become a target of cytotoxic T lymphocytes (CTL). Here we tested nine recoverin-derived HLA-A24-binding peptides for their capacity to elicit antitumor CTL. We observed recoverin-specific CTL responses in two HLA-A24+ CAR+ cancer patients. In addition, the CTL responses were obtained from three of ten CAR– cancer patients and two of six healthy individuals. The CTL precursor frequency of CAR+ cancer patients and that of CAR– cancer patients was higher than that of healthy individuals. Of nine recoverin peptides, R49 (QFQSIYAKF), R49.2 (QFQSIYAKFF), and R64 (AYAQHVFRSF) were discovered to induce the peptide-specific CTL. Taken together, our present data suggest that peripheral activation of recoverin-specific antitumor CTL is likely to contribute to the preferable prognosis of CAR+ cancer patients. Moreover, in cases other than CAR+ cancer patients, recoverin may offer the opportunity to design epitope-based immunotherapeutic approaches for treating HLA-A24+ cancer patients with a recoverin-expressing tumor.
RhoGTPase in Vascular Disease (2019)

Ras-homologous (Rho)A/Rho-kinase pathway plays an essential role in many cellular functions, including contraction, motility, proliferation, and apoptosis, inflammation, and its excessive activity induces oxidative stress and promotes the development of cardiovascular diseases. Given its role in many physiological and pathological functions, targeting can result in adverse effects and limit its use for therapy. In this review, we have summarized the role of RhoGTPases with an emphasis on RhoA in vascular disease and its impact on endothelial, smooth muscle, and heart and lung fibroblasts. It is clear from the various studies that understanding the regulation of RhoGTPases and their regulators in physiology and pathological conditions is required for effective targeting of Rho.
Unresolved Complex Mixtures of Aromatic Hydrocarbons:  Thousands of Overlooked Persistent, Bioaccumulative, and Toxic Contaminants in Mussels (2006)

Comprehensive two-dimensional gas chromatography−time-of-flight−mass-spectrometry can be used to resolve and identify individual petroleum-derived hydrocarbons in unresolved complex mixtures (UCMs), such as those accumulated by mussels (Mytilus edulis). Mussels exhibiting a range of scope for growth values were collected from sites around the UK coast. Tissue extracts from mussels exhibiting impaired health contained large amounts of aromatic hydrocarbon UCMs compared to the extracts from healthy mussels. The UCMs (up to 125 μg g-1 dry tissue) contained thousands of previously unidentified branched alkyl homologues of known aromatic hydrocarbons such as branched alkylbenzenes (BABs), tetralins (BATs), and indanes and indenes (BINs). The toxicity of few such alkyl branched compounds has been investigated previously, but here we show that a commercial mixture of BABs (C12−C14) is toxic to mussels in laboratory tests (11−57 μg g-1 dry tissue), reducing feeding rate by up to 40% in 72 h. Thus, some, if not all aromatic UCMs, apparently comprise potent mixtures of persistent, bioaccumulative and toxic compounds which have been overlooked previously.
Longitudinal studies of nitric oxide and carbon dioxide in human breath with a single IV-VI mid-IR laser (2002)

NO and CO 2 were measured simultaneously in exhaled breath from seven subjects 10 times over a period of 12 days. Exhaled CO 2 was used to estimate NO values as laser characteristics fluctuate over time.
Trace Analysis of benzene in air by carbon dioxide laser-induced thermal lens spectrophotometry (1982)

Thermal lens spectrophotometry was examined using the CO2 laser as an exciting source for trace analysis of benzene in air. Thermal lens signal was recorded by a digital lock-in amplifier system. The sample gas of benzene was generated continuously by the Permeater (Kitazawa, diffusion tube). The detection limit was 500 ppb for benzene with the 9.639 μm line of the CO2 laser (output power : 20 W). This method is useful for the determination of the substances which have no absorption band at the visible region.
Abstract TP428: Microsurgical and Endovascular Treatment of Ruptured Distal Anterior Cerebral Artery Aneurysms (2013)

Introduction: Distal anterior cerebral artery (DACA) aneurysms are less common and surgical morbidity has been reported relatively high due to intraoperative rupture and narrow surgical field. Endovascular treatment can be alternative to surgery. This study investigated the efficacy and safety of endovascular coiling for ruptured DACA aneurysms comparing with microsurgical clipping. Patients and Methods: Between January 1999 and March 2012, consecutive 94 patients with ruptured DACA aneurysm were treated by surgical clipping (n=52, 55.3%) and endovascular coiling (n=42, 44.7%) in five institutions including only 2 cases of recurrence (2.1%, 1 in clip and 1 in coil). The clinical outcomes of patients and procedure-related complications (intraprocedural rupture and any infarction) were evaluated and compared between two groups. Results: There were 38 males and 56 females (mean age; 55.1 years). Initial Hunt-Hess grade was GII in 25 patients (37.2%), GIII in 36 patients (38.3%), GIV in 12 patients (12.8%), and GV in 11 patients (11.7%), which was significantly higher in coil group (2.77 in clip vs 3.26 in coil, p=0.016). Initial CT scanning showed ruptured DACA aneurysm with ICH (n=35; 37.2%) and hydrocephalus (n=25; 26.6%). Maximal diameter of aneurysm was less than 5mm in 36 (38.3%), 5~10mm in 53 (56.4%), and 10mm and more than in 5 (5.3%). Technical success rate was 100% and complete occlusion or neck remnant of aneurysm was achieved in 87 [92.6%, 49 (96.1%) in clip vs 38 (90.5%) in coil, p=0.404] and incomplete in 6 (6.4%). At discharge, favorable outcome (modified GOS; good and fair) was obtained in 70 [77.8%, 44 (84.6%) in clip vs 26 (68.4%) in coil, p=0.078]. Intraprocedural rupture occurred only in clipping group [6 cases (11.5%), p=0.031]. Any procedure-related infarction occurred in 7 [7.4%, 6 (11.5%) in clip vs 1 (2.4%) in coil, p=0.126]. Intraprocedural thrombus was detected in 5 cases of coil group and most of them were restored by thrombolytic therapy. There was one case of acute rebleeding in coiling group and this patient died. Conclusions: Endovascular coiling was comparable treatment with clipping for ruptured DACA aneurysms.
Circuits to Operate a Scintillation Spectrometer Probe with Single Conductor Cable (1962)

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Isolated Buck–Boost DC/DC Converters Suitable for Wide Input-Voltage Range (2011)

A family of isolated buck-boost dc/dc converter for wide input-voltage range is proposed in this paper, and the full-bridge (FB) boost converter, being one of the typical topologies, is analyzed. Due to the existence of the resonant inductor (including the leakage inductor), the FB-boost converter can only adopt the two-edge-modulation (TEM) scheme with the FB cell being leading-edge modulated and the boost cell being trailing-edge modulated to minimize the inductor current ripple over the input-voltage range, and a phase-shift-control-scheme-based TEM with the use of the market available controller IC such as UC3895 is proposed, which realizes phase-shifted control for the FB cell to achieve zero-voltage switching. In order to improve the reliability and efficiency of the FB-boost converter, a three-mode dual-frequency control scheme is proposed, in which the FB-boost converter operates in boost, FB-boost and FB modes in low, medium and high input voltage regions, respectively, and for which the expression of the inductor current ripple is derived in this paper. As the input voltage in the FB-boost mode is close to the output voltage, the inductor current ripple in this mode is much smaller than that in the other modes, and the switching frequency of the boost cell in this mode can be lowered to one-(2N+1)th of the preset switching frequency to reduce the switching loss, and hence, to improve the efficiency. A 250-500 V input, 360 V output, and 6 kW rated power prototype is fabricated to verify the effectiveness of the design and control method. The average efficiency over the input-voltage range is 96.5%, and the highest efficiency attained is 97.2%.
Optical Disk Readout Analysis Using an Extended Point Spread Function (2000)

We present a method to calculate the readout signals from optical disks and their applications. Our method is based on a convolution operation of marks recorded on a disk and an extended point spread function (EPSF). Our method can be applied to the case where the marks are recorded in a groove and the photodetector has an arbitrary shape. Four analyses examples are reported: analysis of the tracking error detection method termed the differential phase detection (DPD), focus shift dependency of readout signal jitter when the marks are recorded in a groove, EPSF for land and groove readout, and a compatible readout method for digital versatile disks and compact disks.
Impaired CD4+ and CD8+ T cell phenotype and reduced chemokine secretion in recent-onset type 1 diabetic children (2008)

Although the role of the T cell-mediated autoimmune reaction in type 1 diabetes (T1D) is conclusive, studies including data from human circulating CD4(+) and CD8(+) lymphocytes subsets during the disease onset and posterior development are scarce. Further, chemokines and chemokine receptors are key players in the migration of pathogenic T cells into the islets of non-obese diabetic mice developing T1D, but few studies have investigated these markers in human T1D patients. We studied the expression of T helper 1 (Th1)- and Th2-associated chemokine receptors, and the two isoforms of CD45 leucocyte antigen on CD4(+) and CD8(+) lymphocytes from T1D and healthy children, as well as the secretion of chemokines in cell supernatants in peripheral blood mononuclear cells. Our results showed increased expression of CCR7 and CD45RA and reduced CD45RO on CD8(+) cells among recent-onset T1D patients. The percentages of CD4(+) cells expressing CXC chemokine receptor 3 (CXCR3), CXCR6 and CCR5, and the secretion of interferon-gamma-induced protein-10, monocyte chemoattractant protein-1, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta was lower among diabetics. Low expression of Th1-associated receptors and secretion of chemokines, together with an increased amount of CD8(+) cells expressing CD45RA and CCR7 in T1D patients therefore might represent suboptimal Th function in T1D, leading to impaired T cytotoxic responses or alternatively reflect a selective recruitment of Th1 cells into the pancreas.
Ewige und nachwirkende Spiele (1986)

Was wohl passiert, wenn man bei einem Summenspiel gegen einige der üblichen, Züge und Spielende betreffenden Regeln verstößt? Die beiden wesentlichen Theorien dieses Kapitels handeln von unparteiischen Spielen: der Theorie von C. A. B. Smith über unparteiische Schleifenspiele, und unserer eigenen Theorie über Spiele mit nachwirkenden und Kompliment-Zügen. Die schwierigeren Theorien über polarisierte Schleifenspiele und der misère-Variante gewöhnlicher polarisierter Spiele werden in den benachbarten Kapiteln besprochen.
Schlangenkäfig‐polymere, 1. Darstellung verschiedener schlangenkäfig‐polyelektrolyte auf der basis von polyacrylamiden und einem anionenaustauscher (1976)

Abstract Aus α‐, β‐ und γ‐Aminosäuren und Acryloylchlorid wurde eine Reihe von Monomeren mit sauren Gruppen erhalten. Ihre Einführung in einen stark basischen, makroporösen Anionenaustauscher (Lewatit®) und anschließende Polymerisation führte zu Schlangenkäfig‐Polyelektrolyten, die durch die restliche Anionenaustauschkapazität, die neuentstandene Kationenaustauschkapazität und die Menge an immobilisierten Grundbausteinen charakterisiert wurden.
Septic cardiomyopathy is improved by enhancing cardiomyocyte denitrosylation capacity (2013)

Objective to test the hypothesis that reducing cardiomyocyte protein S‐nitrosylation can improve myocardial depression associated with sepsis. Methods and results We generated novel transgenic mice overexpressing S‐nitrosoglutathione reductase (GSNOR), an enzyme promoting protein denitrosylation, specifically in cardiomyocytes (GSNOR‐CMTg mice). Echocardiographic measurements showed that GSNOR‐CMTg mice had a significantly improved cardiac function compared to wild‐type (WT) mice 6 hours after lipopolysaccharide (LPS) injection, while no difference was observed at baseline. Analysis of isolated heart function on a Langendorff setup confirmed a higher contractility in GSNOR‐CMTg hearts than in WT hearts after LPS. Isolated GSNOR‐CMTg cardiomyocytes showed increased cell shortening compared to WT cells after LPS, with no differences at baseline. However, we found a similar LPS‐induced depression in intracellular systolic Ca 2+ transients in both genotypes. This suggests that GSNOR‐CMTg cardiomyocytes have an increased Ca 2+ sensitivity after LPS. Finally, we confirmed that overexpression of GSNOR resulted in a decrease in total cardiac protein S‐nitrosylation after LPS. Conclusion Our results indicate that cardiomyocyte‐specific reduction of protein S‐nitrosylation protects against sepsis‐induced cardiac dysfunction, presumably by improving cardiomyocyte Ca 2+ sensitivity.
Managed Dynamic VPN Service: Core Capacity Sharing Schemes For Improved VPN Performance (2007)

Managed service framework enables a service provider to offer more demanding and revenue generating services. IETF proposed Provider Provisioned IP-VPN service is a well known managed service. In [6] we first proposed a new framework to enable managed dynamic VPN service using the notion of topology abstraction. In [7] we proposed several distributed heuristics that can be applied in the context of [6]. The focus of this paper is to study the problem of enabling dynamic managed service using topology abstraction in a centralized manner whose objective is to maximize the network utilization and VPN call performance. The centralized scheme proposed in this paper applies the maximum concurrent flow theory and proposes two extensions to it. The two extension aims at improving the conservative nature of using maximum concurrent flow theory by improving the statistical multiplexing of available core network resources among the VPNs. We study the proposed approaches using a simulation environment of an IP/MPLS network providing managed IP-VPN service with appropriate extensions required to realize the components of the Managed Dynamic VPN Service as proposed in [6].
Primary Omental Torsion in a Pediatric Patient (2017)

Primary omental torsion is a rare cause of acute abdominal pain with a clinical presentation resembling acute appendicitis. Here, we report the case of a 7-year-old child presenting with right lower quadrant pain. Primary omental torsion was discovered upon laparoscopy, and the torsed omentum was excised without postoperative complications. Potential causes, contributing factors, diagnosis, and treatment are discussed.
Three-dimensional unconstrained and constrained image-reconstruction techniques applied to fluorescence, frequency-domain photon migration (2001)

The development of near-infrared (NIR) optical imaging for biomedical optical imaging is hampered by the computational intensiveness of large-scale three-dimensional (3-D) image reconstruction and the potential lack of endogenous contrast for detection of relevant tissue features. In this contribution the inverse optical imaging problem is formulated in three dimensions in a noncompressive geometry as a simple-bound constrained minimization problem in order to recover the interior fluorescence properties of exogenous contrast agent from frequency-domain photon migration measurements at the boundary. The solution of the forward optical diffusion problem for the frustum shape containing fluorescence inclusions of 10:1 contrast is accomplished by use of the Galerkin finite-element formulation. The inverse approach employs the truncated Newton method with trust region and a modification of automatic reverse differentiation to speed the computation of the optimization problem. The image-reconstruction results confirm that the constrained minimization may offer a more logical approach for the 3-D optical imaging problem than unconstrained optimization.
Identification and Characterization of an S-Adenosyl-L-methionine:Δ24-Sterol-C-methyltransferase cDNA from Soybean (1996)

In plants, the dominant sterols are 24-alkyl sterols, which play multiple roles in plant growth and development, i.e. as membrane constituents and as precursors to steroid growth regulators such as brassinosteroids. The initial step in the conversion of the phytosterol intermediate cycloartenol to the 24-alkyl sterols is catalyzed by S-adenosyl-L-methionine: delta 24-sterol-C-methyl-transferase (SMT), a rate-limiting enzyme for phytosterol biosynthesis. A cDNA clone (SMT1) encoding soybean SMT was isolated from an etiolated hypocotyl cDNA library by immunoscreening using an anti-(plasma membrane) serum. The deduced amino acid sequence of the SMT1 cDNA contained three conserved regions found in S-adenosyl-L-methionine-dependent methyltransferases. The overall structure of the polypeptide encoded by the SMT1 cDNA is most similar to the predicted amino acid sequence of the yeast ERG6 gene, the putative SMT structural gene. The polypeptide encoded by the SMT1 cDNA was expressed as a fusion protein in Escherichia coli and shown to possess SMT activity. The growing soybean vegetative tissues had higher levels of SMT transcript than mature vegetative tissues. Young pods and immature seeds had very low levels of the SMT transcript. The SMT transcript was highly expressed in flowers. The expression of SMT transcript was suppressed in soybean cell suspension cultures treated with yeast elicitor. The transcriptional regulation of SMT in phytosterol biosynthesis is discussed.
The beginning of a beautiful friendship: Cross-linking/mass spectrometry and modelling of proteins and multi-protein complexes (2010)

After more than a decade of method development, cross-linking in combination with mass spectrometry and bioinformatics is finally coming of age. This technology now provides improved opportunities for modelling by mapping structural details of functional complexes in solution. The structure of proteins or protein complexes is ascertained by identifying amino acid pairs that are positioned in close proximity to each other. The validity of this technique has recently been benchmarked for large multi-protein complexes, by comparing cross-link data with that from a crystal structure of RNA polymerase II. Here, the specific nature of this cross-linking data will be discussed to assess the technical challenges and opportunities for model building. We believe that once remaining technological challenges of cross-linking/mass spectrometry have been addressed and cross-linking/mass spectrometry data has been incorporated into modelling algorithms it will quickly become an indispensable companion of protein and protein complex modelling and a corner-stone of integrated structural biology.
Eye tracking communication with intubated critically ill patients: a proof-of-concept multicenter pilot study (2022)

This study shows that the use of an eye tracking technology device specifically designed for the intensive care setting, with a short training is easy to use for intubated patient. Patients, relatives and caregivers showed high satisfaction.
Multilayer plastic film chemical recycling via sequential hydrothermal liquefaction (2023)

Multi-material layered plastic films are used in the food packaging industry due to their excellent properties; however they cannot be mechanically recycled. In this study, a two-stage hydrothermal liquefaction (HTL) process is proposed and tested for chemical recycling of a two-layer film made of LLDPE-PET. Experimental results showed that after a first subcritical stage at 325 °C, 94% of terephthalic acid (TPA) is recovered from the PET fraction as a solid and 47% of ethylene glycol in the aqueous phase. The unconverted PE was then used as feedstock for a subsequent supercritical HTL stage at 450 °C for 90 min, achieving mass yields of 47% and 29% in a naphtha-gasoline oil and in an alkane-rich gas, respectively. In conclusion, this work proved that a sequential HTL procedure can be used for chemical recycling of multilayer plastics, allowing the recovery of PET monomers to be recycled back to the PET industry and a paraffinic oil and hydrocarbon-rich gas phase that could be used as feedstock for steam cracking to produce virgin materials.
Just-in-time gain estimation of an RF digitally-controlled oscillator for digital direct frequency modulation. (2003)

A novel method of estimating gain of a digitally-controlled oscillator (DCO) for wireless RF applications is proposed and demonstrated. By executing the calculation algorithm just-in-time at the beginning of every packet, the DCO gain can be conveniently tracked and compensated. Precise and timely knowledge of the DCO gain makes possible various predictive operations of a frequency synthesizer such as the presented digital direct frequency modulation using a hybrid of predictive/closed modulation method. This enables the employment of sophisticated and fully-digital frequency synthesizers capable of compensating for analog nonidealities. The demonstrator test chip has been fabricated in a digital 0.13-/spl mu/m CMOS process. The presented ideas have been incorporated in a fully-compliant Bluetooth transceiver.