gebhart/patrepeval huggingface dataset:
DNA Damage Photoinduced by Cosmetic Pigments and Sunscreen Agents under Solar Exposure and Artificial UV Illumination (2006)

Nanostructured ZnO particles present in skin-care cosmetics and UVB/UVA sunscreen products generate strong oxidizing species (free radicals) when illuminated with UV radiation that can damages human skin and the horny layer. Damage to DNA by ZnO and other pigmentary ingredients in sunscreen formulations under artificial and solar UV exposure has been examined by Agarose gel electrophoresis using pUC 18 DNA plasmids (2686 base-pairs). Initial photoinduced oxidative damage done to DNA plasmids have been probed by nicking assays under in vitro conditions for ZnO. The effects of nanosize ZnO and CeO2 particles, and the newly developed CaO-doped and SiO2-coated CeO2 pigment are compared when subjected to artificial (75-W Hg-lamp) and solar UV radiation. Supercoiled DNA plasmids undergo one nick to produce the relaxed form, followed by a second nick yielding the linear form of the plasmids. The DNA constituents deoxyadenosine-5’-monophosphate (dAMP), guanosine-5’-monophosphate (GMP) and cytidine-5’-monophosphate (CMP) have been examined to assess the photooxidative damage done to these nucleotides under photocatalytic conditions using the cosmetic/sunscreen ZnO pigment. Adsorption of the nucleotide through the phosphate on the positively charged ZnO surface, followed by attack of the ribose/phosphate backbone by photogenerated · OH (and/or · OOH) radicals on the ZnO surface lead to the degradation of the dAMP’s ribose moiety and subsequently to decomposition of the adenine base residue. About 90% mineralization of the ribose/phosphate backbone occurred as evidenced by formation of H2PO4- ions after only 30 min of UV irradiation. The nitrogen atoms of the adenine base were converted to NO3- and NH4+ ions. About 45% of the organic carbons constituting the dAMP ribose backbone was mineralized to CO2 within 8 h of UV irradiation occurring through formation of carboxylic acid intermediates (succinic, acetic and formic), with 85% of the remaining nucleobase ultimately mineralized after 48 h of UV irradiation. Similar occurrences were seen for the GMP and CMP nucleotides.
Quantitative proteomic analysis of differentially expressed proteins in tubers of potato plants differing in resistance to Dickeya solani (2019)

This study aims the detection of proteins associated with increased resistance of tubers to necrotrophic bacteria Dickeya solani in tetraploid and diploid potato plants. Comparative analysis of differently expressed proteins in tuber tissue of potato cultivars and diploid interspecific hybrids of Solanum, differing in resistance to Dickeya solani, was performed using nano-liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS/MS). Two highly resistant (Bea and Humalda) and three susceptible (Irys, Katahdin, Ulster Supreme) potato cultivars, and the highly resistant (DG 00–270) and the susceptible (DG 08–305) diploid clones, were studied. Proteins were extracted from wounded potato tubers inoculated with bacteria at an early symptomatic phase of infection and from controls, i.e., intact tubers and wounded mock-inoculated tubers. Data are available via ProteomeXchange with identifier PXD013009. Eight constitutive differentially expressed proteins with fold changes ≥1.9 and q-value ≤0.1 between the resistant and susceptible cultivar groups after D. solani infection were selected. Probable inactive patatin-03-Kuras 1 and the proteinase inhibitor PTI exhibited significantly increased protein abundances after bacterial inoculation in both resistant cultivars compared to the susceptible cultivars. In the diploid clones, only metallocarboxypeptidase and metallocarboxypeptidase-like inhibitors exhibited much higher fold changes following pathogenic invasion (274.4- and 368.6-fold, respectively) than after mock inoculation (165.5- and 130.7-fold, respectively). These results show that different proteins indicating significant fold changes between the resistant and susceptible potato cultivars and diploid clones are induced at an early phase of symptomatic D. solani infection.
Automated impedance estimation method in low-voltage distribution network for coordinated voltage regulation (2016)

Summary form only given: Internode line impedance values are essential information for achieving coordinated voltage regulation with distributed energy devices. However, in a low-voltage distribution system, these values are difficult to acquire, especially when the devices are installed in an ad hoc manner by individual users. This paper proposes a novel method for automated impedance estimation based on practically available parameters at the terminal nodes. The distributed energy devices measure the terminal parameters and transmit to a host device. Then, the host device estimates the line impedances based on its impedance model and the collected parameters. For practical implementation, the proposed method is built under several assumptions. For example, it is assumed that the phases of terminal voltages are not synchronized owing to communication latency. Instead, only the magnitude value is incorporated during the impedance estimation. The proposed method is verified via a simulation that assumes a realistic environment.
Epigenetic Strategies to Boost Cancer Immunotherapies (2017)

Recently, immunotherapeutic approaches have shown impressive responses in a subset of cancer patients. However, the rate of success is low and a large percentage of treated patients do not experience clinical benefits. Therefore, additional strategies are needed to improve responses and select responsive patients. Emerging data suggest that epigenetic drugs can improve the responses to immunotherapy. Understanding the mechanisms of resistance to immunotherapy and the epigenetic events that take place during immune evasion is critical to providing a rational combined use of immunotherapies and epigenetic drugs. This review focuses in the epigenetic mechanisms involved in the responses to immunotherapy and how current drugs that target epigenetic regulators impact on them.
Subepithelial Fibrosis After RK (2000)

Reply: Mitomycin-C has been used widely in glaucoma filtering surgery to prevent scar formation and resultant bleb failure and in pterygium excision surgery to prevent recurrence of pterygium. The toxic side effects of MMC include hyperemia, pain, blepharospasm, secondary glaucoma, corneal edema, corneal perforation, iritis, corneoscleral melt and perforation, and photophobia. In Majmudar and coauthors' case series, a #64 blade was used to remove the corneal epithelium and mechanically remove as much of the fibrosis as possible. A sterile 6.0 mm circular sponge soaked in MMC (0.02%) was applied to the corneal surface for 2 minutes. Care was taken to limit MMC exposure to the central 6.0 mm of the corneal surface. The sponge was then removed, and the ocular surface was irrigated with 30 mL of balanced salt solution (BSS®). Epithelial plugs and active fibroblasts can exist in corneal wounds for long periods after RK. In our series, the recurrence of the subepithelial fibrosis occurred possibly as a result of wound-site keratocytes activated by the excimer laser ablation. We believe the appropriate surgical management for superficial corneal fibrosis after RK involves manual debridement of the epithelium and manual excision of the fibrotic scar. This was followed by a relatively minimal excimer laser ablation to smooth the corneal surface after removal of the superficial corneal fibrosis. This approach for superficial corneal fibrosis after RK does not include any possibility of toxic side effects from MMC. Currently, there is no randomized study that can completely address the relative safety and efficacy of these 2 procedures. Yi-Chiang Fong MD Roy Chuck MD, PhD Walter Stark MD Peter McDonnell MD
Welpet al. reply (1992)

A reply to the comment on high-field scaling behavior of thermodynamic and transport quantities of YBaCuO near super conducting transition is given. The authors do not agree with Salamon and Shi's suggestions that their high-field scaling of the magnetization of the crystals near the diamagnetic transition is inadequate. (AIP)
Multi-seeded melt crystallization of YBCO bulk material for cryogenic applications (1999)

YBCO bulk materials were crystallized by a multi-seeded melt growth process. Up to four biaxial oriented Sm-123 seeds were placed on the top of rectangular shaped YBCO bars (up to ). The oriented grown single grains are joined by partially coherent grain boundaries with an improved current transport capability and high levitation forces with overall values of 55-65 N. Segregation of nonsuperconducting rest melt and microcracks limit the current transport across the grain boundary.
Role of IL-6, IL-1, and CD28 signaling in responses of mouse CD4+ T cells to immobilized anti-TCR monoclonal antibody. (1994)

Purified CD4+ T cells require TCR engagement and Ag-nonspecific co-stimulatory signals to produce IL-2 and proliferate. A number of recent studies have demonstrated that the interaction of the B7 molecule expressed on APC with the T cell-associated CD28 molecule provides a potent co-stimulatory signal to both freshly isolated CD4+ T cells and cloned Th1 cells. Earlier reports have described the role of cytokines, in particular IL-6 and IL-1, as costimulatory molecules for T cell activation. We previously reported that IL-6 and IL-1 synergize to co-stimulate proliferation of purified mouse CD4+ T cells in conjunction with anti-TCR mAb. In this report we explore the interaction of IL-6, IL-1, and CD28 signaling in the activation of mouse CD4+ T cells, and demonstrate that the co-stimulatory requirements of the cells vary depending on the mode of TCR stimulation. CD28 signaling is not sufficient to co-stimulate responses of high buoyant density CD4+ T cells to anti-TCR-conjugated agarose beads; there is an additional requirement that can be supplied by exogenous IL-6 but not by IL-1. In contrast, in responses to anti-TCR mAb that is passively bound to the bottom of culture wells, CD28 stimulation is sufficient to co-stimulate proliferation, resulting in a very high level of IL-2 production; there is no additional requirement for exogenous IL-6 or IL-1. Possible explanations for the differential requirement for IL-6 in the two systems are discussed. Our results are consistent with the notion that CD28 signaling plays a central role in co-stimulating T cell responses. However, the results also suggest that, depending on the nature of the TCR stimulus, T cell activation may also require additional co-stimulatory signals provided by cytokines.
ChemInform Abstract: A Non‐Metal Catalyzed Oxidation of Primary Azides to Nitriles at Ambient Temperature. (2012)

Abstract The method provides good selectivity as double and triple bonds are not oxidized.
Response of an aspartic protease gene OsAP77 to fungal, bacterial and viral infections in rice (2014)

These results suggest that the expression of OsAP77 is induced by pathogen infection and defense related signaling molecules in a vascular tissue specific manner and that this gene has a positive role of defense response against fungal, bacterial and viral infections.
A Role for Skin γδ T Cells in Wound Repair (2002)

Gammadelta T cell receptor-bearing dendritic epidermal T cells (DETCs) found in murine skin recognize antigen expressed by damaged or stressed keratinocytes. Activated DETCs produce keratinocyte growth factors (KGFs) and chemokines, raising the possibility that DETCs play a role in tissue repair. We performed wound healing studies and found defects in keratinocyte proliferation and tissue reepithelialization in the absence of wild-type DETCs. In vitro skin organ culture studies demonstrated that adding DETCs or recombinant KGF restored normal wound healing in gammadelta DETC-deficient skin. We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair.
Etude de l'adsorption des ions phosphates en réacteurs batch et colonne par du schiste ardoisier de côte d'Ivoire (2016)

International audience
Antiproliferative and apoptotic potential of Chinese medicinal plants against MCF-7 (luminal A), HCC1954 (HER2+) and Hs578t breast cancer cells (2013)

Breast cancer is a significant cause of death among women worldwide. Medicinal plant extracts with large amounts of polyphenolic compounds, which are antioxidants, can have an important role in cancer prevention. The purpose of this study is to test in vitro the antiproliferative activities of the ethanolic and aqueous extracts of selected Chinese medicinal plants against three human breast cancer cell lines [MCF-7 (luminal A); HCC1954 (HER2+); Hs578t (triple negative)] and one normal cell line [MCF-10A]. The ethanolic extracts of Polygonum cuspidatum, Rheum officinale, Eucomia ulmoides, Lysinachia christinae, Rhizoma Alpinae, Sarcandra glabre, Scutellaria baicalensis, Smilax glabra and Atractyloides macrocephala showed potent anti-cancer activity with little or no toxicity to normal cells. The apoptosis test was carried out for one of the active plant extract (S. baicalensis) and the results were found to be very significant. The plant extracts investigated in this study have significant anticancer activity against the breast cancer cell lines tested. Further investigation is required to isolate and elucidate the structure of the compounds responsible for the observed activity.
Medical Image Segmentation Using Seeded Fuzzy C-means: A Semi-supervised Clustering Algorithm (2018)

One of the least invasive means of diagnosing certain diseases is through the use of imaging tests. Automated analysis usually begins by detecting the regions to be investigated and extracting relevant information such as shape and texture. In this paper, we propose a semi-supervised clustering algorithm called Seeded Fuzzy C-means to segment regions of interest in medical images. Seeded Fuzzy C-means is based on the well-known Fuzzy C-means; however, it also uses information provided by the physician to insert constraints during group choices. In this way, the element is placed in a group with a higher degree of certainty. We evaluated the proposed algorithm on a total of 2,200 images in leukemia, skin cancer, cervical cancer, and glaucoma image databases. Two semi-supervised clustering algorithms were implemented from literature to perform this analysis. The results illustrate the ability of the algorithm to efficiently assist physicians in detecting regions of interest, as it achieved an “Excellent” Kappa index in most of the tests.
Protein/Arabinoxylans Gels: Effect of Mass Ratio on the Rheological, Microstructural and Diffusional Characteristics (2014)

Wheat bran arabinoxylan (WBAX) gels entrapping standard model proteins at different mass ratios were formed. The entrapment of protein affected the gel elasticity and viscosity values, which decreased from 177 to 138 Pa. The presence of protein did not modify the covalent cross-links content of the gel. The distribution of protein through the network was investigated by confocal laser scanning microscopy. In mixed gels, protein aggregates forming clusters were detected at protein/polysaccharide ratios higher than 0.25. These clusters were not homogeneously distributed, suggesting that WBAX and protein are located in two different phases. The apparent diffusion coefficient (Dm) of proteins during release from mixed gels was investigated for mass ratios of 0.06 and 0.12. For insulin, Dm increased significantly from 2.64 × 10-7 to 3.20 × 10-7 cm2/s as the mass ratio augmented from 0.06 to 0.12. No significant difference was found for Dm values of ovalbumin and bovine serum albumin released from the mixed gels. The results indicate that homogeneous protein/WBAX gels can be formed at low mass ratios, allowing the estimation of Dm by using an analytical solution of the second Fick's law.
FANGORN: A quality-checked and publicly available database of full-length 16S-ITS-23S rRNA operon sequences (2022)

ABSTRACT Sequence comparison of 16S rRNA PCR amplicons is an established approach to taxonomically identify bacterial isolates and profile complex microbial communities. One potential application of recent advances in long-read sequencing technologies is to sequence entire rRNA operons and capture significantly more phylogenetic information than sequencing of the 16S rRNA (or regions thereof) alone, with the potential to increase the proportion of amplicons that can be reliably classified to lower taxonomic ranks. Here we describe FANGORN ( F ull-length A mplicons for the N ext G eneration O f r RN a analysis), a publicly available database of quality-checked 16S-ITS-23S rRNA operons, accompanied by multiple taxonomic classifications. FANGORN will aid researchers in analysis of their data and act as a standardised database to allow comparison of results between studies.
Themes and Strategies for Studying the Biology of Stroke Recovery in the Poststroke Epoch (2008)

On a cellular level, the phenomenology of neural repair after stroke has been defined and unique regenerative environments in the poststroke brain identified. As the field moves toward specific studies of causal mechanisms in poststroke repair, it will need to maintain a perspective of the animal models suited to the study of neural repair after stroke as they relate to the patterns of recovery in humans in this disease.
A Study on Duration Length and Place of Feature Extraction for Phoneme Recognition (1994)

As a basic research to realize Korean speech recognition system, phoneme recognition was carried out to find out ; 1) the best place which represents each phoneme's characteristics, and 2) the reasonable length of duration for obtaining the best recognition rates. For the recognition experiments, multi-speaker dependent recognition with Bayesian decision rule using 21 order of cepstral coefficient as a feature parameter was adopted. It turned out that the best place of feature extraction for the highest recognition rates were 10~50ms in vowels, 40~100ms in fricatives and affricates, 10~50ms in nasals and liquids, and 10~50ms in plosives. And about 70ms of duration was good enough for the recognition of all 35 phonemes.
Tamoxifen Increases Membrane Fluidity at High Concentrations (2000)

There are contradictory results in the literature relating to the effect of tamoxifen on membrane fluidity. The present work investigates the effect of tamoxifen on membrane dynamics to find out whether the concentration of tamoxifen can be one of the factors in this discrepancy. Turbidity (absorbance at 440 nm) and Fourier transform infrared spectroscopic studies reveal that tamoxifen causes opposite effects on membrane fluidity at low (1 mol.%) and high (30 mol.%) tamoxifen concentrations. Low tamoxifen concentrations increase the absorbance in the gel and liquid crystalline phase, whereas high tamoxifen concentrations decrease the absorbance in gel and liquid crystalline phase, whereas tamoxifen concentrations decrease the absorbance. Observations on both phases show that the bandwidth of the CH2 stretching bands decreases with 1 mol.% tamoxifen and increases with 30 mol.% tamoxifen present, indicating a decrease in membrane fluidity at low tamoxifen concentrations and an increase in fluidity at high tamoxifen concentrations. It is seen that the apparent discrepancy in the literature on the effect of tamoxifen on membrane fluidity mainly arises from the tamoxifen concentration used and the confusion on the concept of lipid fluidity and lipid order.
Generation of control iPSC lines CBRCULi008-A and CBRCULi009-A derived from lymphoblastoid cell lines (2023)

The generation of control human iPSC lines is important in fundamental research to understand the physiological and physiopathological mechanisms underlying human diseases. We generated and characterized two control hiPSC lines from lymphoblastoid cells collected from apparently healthy individuals. These hiPSCs display pluripotency markers, can differentiate into three embryonic germ layers, possess normal karyotypes and colony morphologies, and have no reprogramming viral vectors.
Increasing megakaryopoiesis without promoting the malignant clone in myeloid malignancies (2020)

Thrombocytopenia is a major cause of morbidity and mortality in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) [1]. Ineffective hematopoiesis and infiltration of the...
Synthesis and structures of 1,2-bis(imino)acenaphthene (BIAN) lanthanide complexes that involve the transfer of zero, one, or two electrons (2007)

The syntheses and X-ray crystal structures of the first 1,2-bis(imino)acenaphthene (BIAN) complexes of the lanthanides are described.
Proliferation of Donor Thymus Cells in the Bone Marrow and Spleen of Irradiated Syngeneic Host Mice (1973)

When CBA/H mice were irradiated with 600 R, and injected with 5× 107 ${\rm CBA}/{\rm HT}_{6}{\rm T}_{6}$ thymus cells, donor thymus cells comprised nearly 100% of the dividing population in the host lymph nodes and spleen, and more than 70% in the bone marrow on Day 5, respectively. The percentages of dividing donor thymus cells quickly declined in the bone marrow and spleen, reaching less than 5% by Day 20. When CBA/H mice were irradiated with 600 R, and injected with (a) 1× 107 CBA/H bone marrow cells plus 5× 107 ${\rm CBA}/{\rm HT}_{6}{\rm T}_{6}$ thymus cells, or (b) 1× 107 ${\rm CBA}/{\rm HT}_{6}{\rm T}_{6}$ marrow cells plus 5× 107 CBA/H thymus cells, donor marrow cells comprised more than 50% of the dividing cell population in the bone marrow and spleen on Day 5, nearly 100% by Day 20. The division of donor thymus cells in the bone marrow was totally suppressed after the injection of marrow and thymus cells. The numbers of dividing cell...
SYNTHESIS AND PREDICTION OF THE BIOLOGICAL ACTIVITY OF HETEROCYCLIC N-DERIVATIVES NAPHTHOQUINONE (2019)

The most urgent task of organic and pharmaceutical chemistry today is the search for new biologically active compounds, which in future can be used as promising substances for the development of new low-toxic, high-performance medicinal products. To this end, heterocyclic N-derivatives of 1,4-dichloroanotoquinone were synthesized and their drug-like characteristics were
In vitro immunosuppressive activity of soluble HLA class I and Fas ligand molecules:do they play a role in autologous blood transfusion? (2001)

The results of the present study are comparable with those already reported in allogeneic blood components, and they indicate that undiluted supernatants of autologous blood components may exert immunosuppressive effects in vitro.