gebhart/patrepeval huggingface dataset:
Supramolecular non-symmetric dimers derived from cholesterol: synthesis and phase transitional properties (2016)

Three series of novel dimeric supramolecules, possessing both inter- as well as intramolecular H-bonding, have been prepared and investigated for their thermal properties. They were obtained in excellent yields by condensing cholesteryl ω-(3-hydroxy-4-formylphen-oxy)alkanoates with 4-(n-alkoxy)benzohydrazides, 3,4-bis(n-decyl-oxy)benzohydrazide and 3,4,5-tris(n-decyloxy)benzohydrazide. The influence of increase in the number of terminal n-alkoxy tails from one to three and the length and parity of the flexible spacer on phase transitional behaviour have been thoroughly investigated with the aid of microscopic, calorimetric and X-ray diffraction (XRD) techniques. The results of these complementary studies clearly illustrate the dependence of thermal behaviour of the dimers on these structural factors. The rigid intermolecular association via H-bonds through complementary benzohydrazide component enforce their self-assembly into frustrated and polar smectic phases; H-bond force coupled with the bulkiness of steroid moiety affects the electrical switching property of this fluid polar structure.
Intraoperative cholangiography in laparoscopic cholecystectomy: a review of 734 consecutive cases. (1997)

Intraoperative cholangiography was first introduced by Mirizzi in 1931. He recommended its routine use. The debate over the appropriate role of intraoperative cholangiography was renewed by the widespread acceptance of laparoscopic cholecystectomy in 1988. We reviewed our experience to determine the most appropriate use of intraoperative cholangiography. Seven hundred thirty-four consecutive cases of laparoscopic cholecystectomy performed between January 1, 1991 and December 31, 1993 were reviewed. The Routine Group of 276 cases, performed by 3 surgeons practicing routine cholangiography, was compared to the Selective Group of 458 cases, performed by 16 surgeons practicing selective cholangiography. The groups were similar in terms of age, sex, and extent of disease. No statistically significant difference was found between the two groups in number of successful cholangiograms, filling defects, misinterpretation of cholangiograms, complications, or length of hospitalization. One common duct injury occurred in the Routine Group. The rate of conversion to open cholecystectomy was higher in the Routine Group. A cholangiogram added 14 minutes to the average duration of surgery and $737 to the average cost. We found that routine cholangiography did not increase common duct stone detection, did not decrease common duct injury, and did not increase technical skill, but it did increase cost. We feel that intraoperative cholangiography should be used selectively where choledocholithiasis is suspected or biliary anatomy is unclear.
The growth behavior of intermetallic compound layers of Sn-3Ag / Cu and Sn/Cu joints during soldering and aging (2006)

The growth behaviors of Sn-3Ag/Cu and Sn/Cu IMC layers during soldering and aging have been investigated. In the soldering experiments, both the Sn-3Ag/Cu and Sn/Cu were soldered at 270 degC for different time. In the aging experiments, the Sn-3Ag/Cu and Sn/Cu joints were firstly soldered at 270 degC for 60s, and aged at 120 degC, 170 degC, 190 degC for various time. Then all the samples were observed under scanning electron microscopy (SEM). The average thickness of IMC layers was measured by using Q500IW image analysis meter. The results indicated that in the soldering the growth rate of Sn-3Ag/Cu IMC layers was faster than that of Sn/Cu. However, in the aging the growth rate of Sn-3Ag/Cu IMC layers was lower than that of Sn/Cu. The activation energies of Sn-3Ag/Cu and Sn/Cu IMC layers in the aging were about 90KJ/mol and 52KJ/mol respectively
[Schwartz-Bartter syndrome. Presentation of a sub-glottal small cell laryngeal carcinoma (author's transl)]. (1979)

Inappropriate secretion of antidiuretic hormone or Schwartz-Bartter syndrome is considered to be a paraneoplastic endocrine syndrome, most frequently associated with a small cell anaplastic carcinoma of the lung. The authors present a case of sub-glottal laryngeal carcinoma discovered several months after the onset of clinical (disturbances of conscious level) and laboratory (hyponatraemia, hypochloraemia, blood hypo-osmolarity which preservation of urinary sodium output) manifestations which form the original features of this syndrome, the criteria of which are reviewed. The y conclude by the need for complete examination, not excluding unusual sites of primary tumour.
Case Studies in Sports Nutrition (1988)

In brief: With the recent plethora of research indicating that food affects performance, athletes are eager to learn how to eat to win. They recognize that sound nutrition practices are an integral part of their training program. Hence, sports-active people of all ages and athletic abilities are increasingly receptive to professional nutrition advice. This article presents two case reports of athletes who consulted the author for advice regarding diverse problems: One wanted to stabilize her blood sugar and lose weight; the other wished to gain weight. Both wanted to enhance their athletic performance.
Statistical process control analysis for patient-specific IMRT and VMAT QA (2012)

This work applied statistical process control to establish the control limits of the % gamma pass of patient-specific intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) quality assurance (QA), and to evaluate the efficiency of the QA process by using the process capability index (Cpml). A total of 278 IMRT QA plans in nasopharyngeal carcinoma were measured with MapCHECK, while 159 VMAT QA plans were undertaken with ArcCHECK. Six megavolts with nine fields were used for the IMRT plan and 2.5 arcs were used to generate the VMAT plans. The gamma (3%/3 mm) criteria were used to evaluate the QA plans. The % gamma passes were plotted on a control chart. The first 50 data points were employed to calculate the control limits. The Cpml was calculated to evaluate the capability of the IMRT/VMAT QA process. The results showed higher systematic errors in IMRT QA than VMAT QA due to the more complicated setup used in IMRT QA. The variation of random errors was also larger in IMRT QA than VMAT QA because the VMAT plan has more continuity of dose distribution. The average % gamma pass was 93.7% ± 3.7% for IMRT and 96.7% ± 2.2% for VMAT. The Cpml value of IMRT QA was 1.60 and VMAT QA was 1.99, which implied that the VMAT QA process was more accurate than the IMRT QA process. Our lower control limit for % gamma pass of IMRT is 85.0%, while the limit for VMAT is 90%. Both the IMRT and VMAT QA processes are good quality because Cpml values are higher than 1.0.
A role for expectant management in severe preeclampsia (2002)

Although controversial, delivery is usually recommended for all women with severe preeclampsia--regardless of gestational age. But premature delivery can pose a major threat to the periviable fetus. When is it appropriate to expectantly manage severe preeclampsia?
Toward Catalytic, Enantioselective Chlorolactonization of 1,2-Disubstituted Styrenyl Carboxylic Acids (2016)

An investigation into the use of Lewis base catalysis for the enantioselective chlorolactonization of 1,2-disubstituted alkenoic acids is described. Two mechanistically distinct reaction pathways for catalytic chlorolactonization have been identified. Mechanistic investigation revealed that tertiary amines predominately operate as Brønsted rather than Lewis bases. Two potential modes of activation have been identified that involve donation of electron density of the carboxylate to the C═C bond as well hydrogen bonding to the chlorinating agent. Sulfur- and selenium-based additives operate under Lewis base catalysis; however, due to the instability of the intermediate benzylic chloriranium ion, chlorolactonization suffers from low chemo-, diastereo-, and enantioselectivities. Independent generation of the benzylic chloriranium ion shows that it is in equilibrium with an open cation, which leads to low specificities in the nucleophilic capture of the intermediate.
Removal of Hydrogen Sulfide from a Steam-Hydrogasifier Product Gas by Zinc Oxide Sorbent (2007)

Removal of H2S by a commercially available zinc oxide sorbent was studied using a packed-bed reactor for desulfurizing the gas produced from steam-hydrogasification of carbonaceous materials. Experimental runs were conducted to monitor sulfur removal efficiency and H2S breakthrough time for the operation variables such as reaction temperature, steam content, space velocity, inlet H2S concentration, and sorbent particle size. For the inlet gas with 45 vol % steam content, the initial sulfur removal efficiency exhibited a maximum around 636 K. Varying the steam content of inlet gas affected the equilibrium of sorbent sulfidation in a reversible way, leading to the decrease of sulfur capture capacity of the sorbent as the steam content increased. Increasing the space velocity from 8 000 to 24000 h-1 decreased sulfur capture capacity significantly, indicating the deterioration of gas−solid contact in the reactor at the increased gas flow rates. Inlet H2S concentration was varied from 100 to 800 ppmv to reflect the diversity of steam-hydrogasifier feedstocks, which affected sulfur capture capacity of the sorbent in such a way that the extent of sorbent utilization was limited by the increased H2S concentration. Sorbent particle size was varied from 150−250 to 425−1000 μm to look into the effect of intraparticle mass transfer limitation. The particles greater than 425 μm exhibited the sulfur capture capacity that was limited by the reduced extent of sorbent utilization.
NMDA-receptors are involved in Cu2+/paraquat-induced death of cultured cerebellar granule neurons (2016)

Rat cultured cerebellar granule neurons (CGNs) were not sensitive to CuCl2 (1-10 µM, 24 h), whereas paraquat (150 µM) decreased neuronal survival to 79 ± 3% of control level. Simultaneous treatment of CGNs with paraquat and CuCl2 (2, 5, or 10 µM Cu2+/paraquat) caused significant copper dose-dependent death, lowering their survival to 56 ± 4, 37 ± 3, or 16 ± 2%, respectively, and stimulating elevated production of free radicals in CGNs. Introduction of vitamin E, a non-competitive antagonist of NMDA subtype of glutamate receptors (MK-801), and also removal of glutamine from the incubation medium decreased toxicity of Cu2+/paraquat mixture. However, addition of Cu2+ into the incubation medium did not affect CGNs death caused by glutamate. These data emphasize that excessive copper in the brain may trigger oxidative stress, which in turn results in release of glutamate, overstimulation of glutamate receptors, and neuronal death.
cis,cis-1,3,5-Trihydroxynonamethylcyclohexasilane: A Cyclopolysilane with Unusual Properties (2011)

cis,cis-Trihydroxynonamethylcyclohexasilane (2) is easily accessible by the controlled hydrolysis of Cl3Si6Me9 in the presence of Et3N as an auxiliary base. The crystal structure of 2, as determined by single-crystal X-ray crystallography, exhibits “barrel-type” face-to-face dimeric aggregates held together by six intermolecular hydrogen bonds. NMR and IR spectra suggest that these OH-bonded aggregates are also present in nonpolar solutions. Full geometry optimization (B3LYP/TZVP) of the gas-phase structure of 2 further reveals unusually high energy differences between different conformers and a considerable stabilization of the molecule upon dimerization due to O−H hydrogen bonding. Time-dependent DFT B3LYP/TZVP calculations allow for a detailed interpretation of the UV absorption spectra of 2. The electronic transitions occur between occupied molecular orbitals with predominant σ(Si−Si) character and a small contribution of the oxygen lone pairs, and virtual MOs with contributions from σ*(Si−C), σ*(Si−O), and σ*(Si−Si) type orbitals. If 2 is reacted with MeSiCl3/Et3N, the adamantane-like cage MeSi(O3Si6Me9) (4) is obtained without the formation of considerable amounts of polymeric material, which is most likely a consequence of the preferred conformation of 2 with three adjacent OH groups in axial positions.
Mechano‐chemical effects of Ca2+ in cross‐linked troponin‐C films (2002)

Changes in troponin C (TnC) conformation upon Ca(2+) binding forms the basis for regulatory and structural functions of TnC molecules. In the present study, Ca(2+)-induced conformational changes in TnC were observed by mechanical measurements. TnC films were prepared by drying or electrospraying TnC solutions, cross-linked with glutaraldehyde, and isometric tension and stiffness measured as a function of pCa. An increase in Ca(2+) from a pCa of 9 to 4 induced large-scale mechanical changes in the TnC films causing several percent shrinkage of the unloaded films. This shrinkage could be partially assigned to Ca(2+) binding to the Ca(2+)/Mg(2+) sites of TnC.
Clinical Use of Bioactive Glasses for Maxillo-Facial Repair (2008)

Autogenous bone grafts are considered to be the gold standard in maxillo-facial surgery. However, drawbacks of donor site morbidity and unpredictable rates of resorbtion often limit their use. In vivo tests have shown that 45S5 bioactive glass particles placed in critical size bone defects lead to regeneration of new bone that has the structural characteristics and architecture of mature trabecular bone. In vitro tests using primary osteoblast cultures have shown that the bioactive glass particles release ionic dissolution products that provide genetic stimuli that control osteoblast cell cycles and lead to rapid growth of mineralized bone nodules. These in vitro and in vivo results led to approval of use of bioactive glass particles and monolithic bioactive glass implants for use in maxillo-facial reconstructions after removal of bone cysts and trauma, as described by several case histories.
A comparative analysis of nat hole punching (2011)

of the main techniques for IPv6&amp;lt;-&amp;gt;IPv4 translation [8], despite the declarations of the IETF to the contrary [1]. It can also be assumed that some people and organizations will continue to use
Comparison of performance, switching energy and process variations for the TFET and MOSFET in logic (2011)

A detailed circuit assessment of Tunneling Field Effect Transistors (TFET) versus MOSFET operating near device threshold supply voltage, including the consideration of process variations, is reported. The analysis incorporates simulated 20nm TFET and MOSFET device characteristics combined with detailed circuit simulation. For very low power logic applications requiring near device threshold supply voltage, the results show that TFET logic can operate at equal standby power and switching energy to MOSFET, but with a ∼8x performance advantage. The study also shows that device parameter variation is not a significant factor for differentiation between MOSFET and TFET.
Alternative two‐step matrix application method for imaging mass spectrometry to avoid tissue shrinkage and improve ionization efficiency (2013)

Mass spectrometry (MS) was used to measure the concentrations of drug and biological compounds in plasma and tissues. Matrix-assisted laser desorption/ionization (MALDI) imaging MS (IMS) has recently been applied to the analysis of localized drugs on biological tissue surfaces. In MALDI-IMS, matrix application process is crucial for successful results. However, it is difficult to obtain homogeneous matrix crystals on the tissue surface due to endogenous salts and tissue surface heterogeneity. Consequently, the non-uniform crystals degrade the quality of the spectrum and likely cause surface imaging artifacts. Furthermore, the direct application of matrix solution can cause tissue shrinkage due to the organic solvents. Here, we report an alternative two-step matrix application protocol which combines the vacuum deposition of matrix crystals and the spraying of matrix solution to produce a homogeneous matrix layer on the tissue surface. Our proposed technique can also prevent cracking or shrinking of the tissue samples and improve the ionization efficiency of the distributed exogenous material.
Radiation patterns in far field from two H -plane coupled rectangular microstrip antennas (1982)

Numerically determined far-field radiation patterns are found for H-plane mutual coupling between two rectangular microstrip antennas. A simple closed-form radiation model is used in the analysis.
Effect of four disintegrins on the adhesive and metastatic properties of B16F10 melanoma cells in a murine model. (1995)

Four disintegrins, eristostatin, albolabrin, barbourin and echistatin, injected IV into C57BL/6 mice in combination with B16F10 murine melanoma cells, inhibited formation of experimental lung metastases with ID50s of 0.05, 1.0, 0.9, and 3.7 mumoles per mouse, respectively. When injected 1 h after tumor cells, albolabrin, echistatin and barbourin had the same antimetastatic activity, while eristostatin was not active. Eristostatin (IC50 7-8 nM) was more potent than echistatin (IC50 74-75 nM), barbourin (IC50 46-60 nM), and albolabrin (IC50 130-165 nM) as an inhibitor of murine platelet aggregation induced by ADP or tumor cells. Fibronectin was the best substrate for melanoma cell adhesion (95%), followed by laminin (47%) and vitronectin (24%). Albolabrin was the strongest and eristostatin the weakest inhibitor of cell adhesion to all substrata. Adhesion of melanoma cells to albolabrin, echistatin, and barbourin was partially inhibited by monoclonal antibody against mouse alpha v subunit. This antibody bound to B16F10 melanoma cells in suspension and inhibited binding of fluorescein isothiocyanate (FITC)-labeled disintegrins to these cells, being the most effective with FITC-labeled albolabrin. Our study suggests that a major contribution of eristostatin to inhibition of lung colonization is via preferential binding to platelet alpha IIb beta 3 integrin and blocking tumor cells interaction with platelets. A major contribution of albolabrin, barbourin and echistatin appears to be by interference with other integrin receptors on the tumor cell surface. Albolabrin appeared to inhibit RGD-dependent integrins containing alpha v subunit, such as alpha v beta 3 and alpha v beta 1.
The Skyrocketing Cost of Rectal Indomethacin (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
A video display processing platform for future TV concepts (1999)

This paper presents a generic multiprocessor architecture for video processing, featuring an array of programmable application-specific coprocessors and a programmable switch-bar communication network. Key advantages of the platform are that the order of functions can be changed and that video tasks can be programmed at system and functional levels using tasks of any length, by applying dynamic data-flow. This modular concept is cost-effective and suitable for a large range of applications and features in the video domain. The system can be well applied in combination with microcontrollers or media processors and it is used for implementing an experimental TV platform.
Libraries and Information Services in a Post-Technological Society (1981)

Technological imperatives will produce major changes in society in the future, as they have in the past. Post-technological society will affect the way we work, where we live, and how we spend our leisure. Changes in educational and research directions and in publishing and information delivery will affect the role and shape of the library of the future.
Wireless Physiological Sensor System for Ambulatory Use (2006)

A wearable physiological sensor system (PSS) has been built that can be used with a wireless control unit to monitor the physiological status of a mobile user. Two physiological variables, heart rate and respiratory rate, were selected for initial study. The PSS was required to be noninvasive, lightweight, and low-power. Initial studies indicated that heart rate could be effectively measured using infrared light technology and so this was implemented in a wrist strap. Respiratory rate was recorded using a novel implementation of conducting polymer strain gauges. For this purpose, polypyrrole-coated Lycra was fabricated and a chest strap was made that incorporated this sensor. Both sensors were connected to the PSS unit that was designed to provide the necessary signal processing; the output signals were then analyzed by the microcontroller in the control unit that is used to activate a wearable tactile display.
Interaction products of cytotoxic Cu(I) complexes with different solvent mixtures: an electrospray ionization mass spectrometry and density functional theory study (2016)

Dimethyl sulfoxide (DMSO) and acetonitrile (MeCN) strongly affect [Cu(P)<sub>n</sub> ]<sup>+</sup> assemblies producing mixed-ligand [Cu(P)(DMSO)]<sup>+</sup> and [Cu(P)(MeCN)]<sup>+</sup> species. Excess of both DMSO and MeCN solvents are able to fully displace coordinated phosphines giving [Cu(solv)<sub>2</sub> ]<sup>+</sup> -type adducts. The presence of phosphines in the native complex is mandatory to retain the reduced oxidation state of copper. Instead, the more labile [Cu<sup>I</sup> (MeCN)<sub>4</sub> ]<sup>+</sup> complex dissolved in DMSO and MeCN displays a combination of Cu(I) and Cu(II) adducts. Copyright © 2016 John Wiley & Sons, Ltd.
AcrD of Escherichia coli Is an Aminoglycoside Efflux Pump (2000)

AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain.
Combined Fluorescence-Guided Surgery and Photodynamic Therapy for Glioblastoma Multiforme Using Cyanine and Chlorin Nanocluster (2020)

Teng, Clare W; Amirshaghaghi, Ahmad; Cho, Steve S BS; Cai, Shuting; De Ravin, Emma; Singh, Yash; Miller, Joann; Sheikh, Saad; Delikatny, Jim PhD; Cheng, Zhiliang; Busch, Theresa; Singhal, Sunil; Dorsey, Jay MD, PhD; Tsourkas, Andrew PhD; Lee, John Y.K MD Author Information