gebhart/patrepeval huggingface dataset:
Peritumoral edema on magnetic resonance imaging predicts a poor clinical outcome in malignant glioma (2015)

Peritumoral edema (PTE), one of the main characteristics of malignant glioma, is a significant contributor to the morbidity and mortality from glioma, however, a recent systematic review suggested that controversy remains with regard to its prognostic value. To further determine whether PTE was a potential prognostic factor on routine pre-operative magnetic resonance imaging (MRI) for malignant glioma, the association between survival and PTE was investigated in the present retrospective review of 109 patients with newly diagnosed supratentorial malignant glioma using MRI data from these routine scans. The Kaplan-Meier method was used to calculate overall survival (OS) in univariate analysis, and COX proportional hazards model was applied to evaluate the effect of pre-operative MRI features on OS in multivariate analysis. The PTE extent, edema shape, degree of necrosis, enhancement extent, pathological grade, patient age, Karnofsky performance status (KPS) and post-operative chemoradiotherapy were associated with OS in the patients with malignant glioma on univariate analysis. Multivariate analysis indicated that the extent of PTE and degree of necrosis shown by pre-operative MRI were independent predictors of OS, in addition to pathological grade, patient age, KPS and post-operative chemoradiotherapy. Moreover, patients with two unfavorable factors (major edema and severe necrosis) exhibited a poorer OS compared with the remainder. In summary, PTE and degree of necrosis, which are easily determined from routine MRI, can be useful for predicting a poor clinical outcome in patients with newly diagnosed malignant glioma.
An efficient method for driver fatigue state detection based on deep learning (2019)

The driver fatigue detection method based on traditional image processing technology suffers from low accuracy due to object rotation, illumination change, and object occlusion. This paper proposed an efficient method for detecting driver fatigue state based on face infrared image and deep learning. The method performed face detection and feature point locating through a cascaded network with depthwise separable convolution as the core, then acquired the eye region according to the feature point coordinates and then performed eye state recognition. Finally, the PERCLOS criterion was used for fatigue judgment, and then the result was output. The experimental results showed that the accuracy of the proposed method is 96.2%, and the average time is 32.4 milliseconds, which is better than the existing methods and can effectively detect the fatigue state of the driver. This method is important for the protection of drivers and traffic safety.
Vegetative Compatibility and Seasonal Variation Among Isolates of Sclerotinia homoeocarpa (2001)

Dollar spot of amenity turf, caused by Sclerotinia homoeocarpa, occurs in two seasonal epidemics in the northern United States, one from May to late July and a second from mid-August through October. It is not known whether these seasonal epidemics are the result of multiple species or due to seasonal variation within a single species. Isolates of S. homoeocarpa were collected from dollar spot lesions obtained from golf courses in Michigan, Illinois, and Wisconsin. Vegetative compatibility reactions between isolates identified six vegetative compatibility groups (VCGs) among more than 1,300 isolates collected from the eight locations. Most VCGs were present throughout the season, but one was generally recovered only in the late epidemic. Sequences of the nuclear ribosomal internal transcribed spacer 1 (ITS1) were identical among VCGs, indicating that the VCGs represent a single species. The results of this study suggest that the seasonal dollar spot epidemics observed in the northern United States are caused by a single species.
Cellular Responses of Bioabsorbable Polymeric Material and Guglielmi Detachable Coil in Experimental Aneurysms (2002)

This preliminary animal study indicates that acceleration of aneurysm healing with the use of BPM is feasible. This concept can be applied to decrease and perhaps prevent aneurysmal recanalization after endovascular treatment of cerebral aneurysms.
Depressive Symptoms, Menopausal Status, and Climacteric Symptoms in Women at Midlife (2001)

In this sample of women age 45 to 54 years, climacteric symptoms but not menopausal status were associated with higher rates of depressive symptoms.
A simple and efficient method to search for selected primary transcripts: non-coding and antisense RNAs in the human pathogen Enterococcus faecalis (2011)

Enterococcus faecalis is a commensal bacterium and a major opportunistic human pathogen. In this study, we combined in silico predictions with a novel 5'RACE-derivative method coined '5'tagRACE', to perform the first search for non-coding RNAs (ncRNAs) encoded on the E. faecalis chromosome. We used the 5'tagRACE to simultaneously probe and characterize primary transcripts, and demonstrate here the simplicity, the reliability and the sensitivity of the method. The 5'tagRACE is complementary to tiling arrays or RNA-sequencing methods, and is also directly applicable to deep RNA sequencing and should significantly improve functional studies of bacterial RNA landscapes. From 45 selected loci of the E. faecalis chromosome, we discovered and mapped 29 novel ncRNAs, 10 putative novel mRNAs and 16 antisense transcriptional organizations. We describe in more detail the oxygen-dependent expression of one ncRNA located in an E. faecalis pathogenicity island, the existence of an ncRNA that is antisense to the ncRNA modulator of the RNA polymerase, SsrS and provide evidences for the functional interplay between two distinct toxin-antitoxin modules.
Production of I2+ from Methyl Iodide: Ion-Molecule Reactions under Multiple Collision Conditions vs Cluster Chemistry (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProduction of I2+ from Methyl Iodide: Ion-Molecule Reactions under Multiple Collision Conditions vs Cluster ChemistryGopalakrishnan Vaidyanathan, Michael Y. M. Lyktey, James J. Stry, Robert L. DeLeon, and James F. GarveyCite this: J. Phys. Chem. 1994, 98, 31, 7475–7478Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://doi.org/10.1021/j100082a015RIGHTS & PERMISSIONSArticle Views54Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (505 KB) Get e-Alerts
Electrical properties of Ta-doped SnO2 thin films prepared by the metal–organic chemical-vapor deposition method (2001)

Undoped and Ta-doped SnO2 (Sn1−xTaxO2) thin films were prepared on Corning 7059 glass substrates by the metal–organic chemical-vapor deposition method. The relative amount of Ta, CTa=XTa/(XTa+XSn), varied from 0 to 7.13 at. %. For the five compositions studied, the lowest resistivity at room temperature was 2.01×10−4 Ω cm at CTa=3.75% with charge carrier density and mobility of 1.27×1021 cm−3 and 24.5 cm2/V s, respectively. In microstructural investigation, 3.75% Ta-doped film maintains a growth pattern of initial stage growth while 7.13% Ta-doped film has a high population of small grains at the interface, which results in large grains through competitive growth. The resistivity of the undoped film was 0.17 Ω cm with charge carrier density and mobility of 1.31×1018 cm−3 and 28.1 cm2/V s obtained from Hall measurement. This study suggests that Ta is an excellent n-type dopant in SnO2.
Direct Synthesis of Pyridyl Disulfide‐Terminated Polymers by RAFT Polymerization (2007)

Abstract A trithiocarbonate RAFT agent was modified with a pyridyl disulfide group and used in the direct synthesis of endgroup pyridyl disulfide‐functionalized homo‐ and amphiphilic block copolymers of oligo(ethyleneglycol) acrylate (PEG‐A) and butyl acrylate (BA). Both the homo‐ and copolymerizations were found to be well controlled via the RAFT mechanism. The NMR analysis indicated that both the homopolymers of PEG‐A and the amphiphilic diblock copolymers of PEG‐A and BA possessed pyridyl disulfide terminal groups. A UV‐Vis absorption test revealed that the pyridyl disulfide endgroup of the polymer could be efficiently used to couple thiol‐bearing molecules to the polymer without the need for any post‐polymerization modification. This communication presents the first efficient direct synthesis of thiol‐reactive endgroup‐functionalized well‐defined polymers via the RAFT technique. magnified image
On systematic cross-layer design for ad hoc networks (2008)

There exist a large amount of research efforts that claim cross-layer design in multi-hop wireless networks. However, almost all of such works use the idea of cross-layering in some ad hoc manner, and different cross-layer designs generally do not work together. To this end, we argue that cross-layer design in such networks should follow some systematic approach, in order to provide a common ground for alternative comparison and integration. In this position paper, we identify two key components toward achieving this ultimate goal of systematic cross-layer design. First, a rigorous mathematical framework is needed to provide the unifying approach for cross-layering, and in this work we choose the well-recognized Generalized Network Utility Maximization (GNUM) approach. Second, with the components availed by the mathematical framework, a composable software ldquoworkbenchrdquo is needed to ldquogluerdquo the various components into some prototype alternatives for inspection. We will discuss how such composability may be achieved via our unique ontology-based modeling and simulation approach.
DNA analysis by flow cytometry in lymphomatoid papulosis (1983)

DNA analysis by flow cytometry revealed normal DNA histograms in three patients (seven skin specimens) with ‘classical’ lymphomatoid papulosis, A fourth patient, also with a‘classical lynphomatoid papulosis, had an increased number of tetraploid nuclei (14%, and 28%). The fifth patient with recurrent tumours, no papules and a more malignant histology showed ancuploidy by sequential examinations (hyperdiploidy and hypertetraploidy) of three skin specimens.
ChemInform Abstract: Novel and Selective Calcitonin‐Inducing Agents. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Learning of object manipulation operations from continuous multimodal input (2011)

In this paper we propose an approach for identification of high-level object manipulation operations within a continuous multimodal time-series. We focus on a multimodal approach for robust recognition of action primitive data. Our procedure combines an unsupervised Bayesian multimodal segmentation with a supervised machine learning approach. We briefly outline (1) the unsupervised segmentation and selection of uni- and bi-manual manipulation primitives developed in our previous work. We show (2) an application of the ordered means models to classification of estimated segments. To assess the performance of our approach, we compare the computed labels to the ground truth acquired during the data recording. In our experiments we examined the robustness of the procedure on two different sets of segments: full length (≈ 95% overlap with the ground truth on average), partial length (≈ 10% overlap with ground truth on average). We have achieved a cross validation rate of ≈ 0.95 and recognition accuracy of ≈ 0.97 for full length and ≈ 0.84 for partial length test sets.
The presence of bioactive peptides in hydrolysates prepared from processing waste of sardine (Sardina pilchardus) (2001)

Abstract A proteolytic enzyme, Alcalase®, was used to produce partly digested proteins from cooked wastes of sardine ( Sardina pilchardus ). The presence of biologically active molecules was investigated in these hydrolysates prepared under various conditions of time and enzyme/substrate ratio. By means of radioimmunoassays and mitogenic and radioreceptor assays, the presence of molecules related to secretagogue peptides, growth factors and calcitonin gene‐related peptide (CGRP) respectively was detected in the hydrolysates. Exclusion chromatography permits the conclusion that the biological activity of the different fractions is related to their size. © 2001 Society of Chemical Industry
Treatment of the Systemic Capillary Leak Syndrome with Terbutaline and Theophylline: A Case Series (1999)

A regimen of terbutaline and theophylline seems to be effective prophylaxis against the systemic capillary leak syndrome. Maintenance of therapeutic drug levels was associated with favorable results.
Adipose-Derived Regenerative Cells for the Treatment of Patients with Non-revascularisable Ischaemic Cardiomyopathy – The PRECISE Trial (2012)

Adipose-derived regenerative cells (ADRCs) continue to be evaluated for use in the treatment of patients with chronic heart failure, particularly in those refractory to, or not suitable for, currently available options. This population of cells has demonstrated the ability to facilitate wound repair through the restoration of blood flow in ischaemic conditions, reduction in inflammation and apoptosis, and regeneration of damaged tissue through stem cell differentiation into multiple cell lineages, including cardiac muscle. This approach is particularly useful in the repair or restoration of function to ischaemic tissues in patients where the body’s natural repair mechanisms have failed or been exhausted, such as patients with non-revascularisable, refractory heart failure. The use of ADRCs for these patients has numerous advantages. Primarily, the cells are accessed from a patient’s own tissue, minimising the risk of disease transmission or rejection. Further, the heterogeneity of the cells generates an orchestrated response that targets all phases of the wound healing process. Finally, the cells are readily accessible in real-time without the need for cell expansion, making it a virtually off-the-shelf therapy option. The Celution® System is a safe, GMP-compliant technology designed to automate the preparation of ADRCs at the patient’s bedside. It has been clinically validated for safety and feasibility in two completed cardiac trials; one for acute myocardial infarction and the other for chronic myocardial ischaemia. It is being further evaluated in two ongoing clinical trials for the same indications. In this article, a summary of 18-month follow-up data using the Celution technology for the treatment of patients with non-revascularisable, symptomatic, ischaemic cardiomyopathy will be presented. While additional studies are planned to confirm the efficacy of these cells in the cardiac setting, early clinical data shows promising trends towards the improvement of cardiac function and mortality rate using a technology that can potentially significantly reduce treatment costs compared to the current standard-of-care.
PspE (phage‐shock protein E) of Escherichia coli is a rhodanese (2002)

The psp (phage-shock protein) operon of Escherichia coli is induced when the bacteria are infected by filamentous phage and under several other stress conditions. The physiological role of the individual Psp proteins is still not known. We demonstrate here that the last gene of the operon, pspE, encodes a thiosulfate:cyanide sulfurtransferase (EC 2.8.1.1; rhodanese). Kinetic analysis revealed that catalysis occurs via a double displacement mechanism as described for other rhodaneses. The K(m)s for SSO3(2-) and CN- were 4.6 and 27 mM, respectively.
Pattern Geometry Effects in the Chemical‐Mechanical Polishing of Inlaid Copper Structures (1994)

We describe an investigation into the pattern dependence of dishing and erosion during the chemical‐mechanical polishing of copper used for delineating inlaid metal patterns. Copper dishing is determined to be highly dependent on the width of the copper structure, but only minimally dependent on the density of copper structures. Erosion of the dielectric layer is strongly affected by the pattern density, but not affected by changes in the width of the copper lines. As a result, both line width and pattern density are important considerations in predicting the final thickness of the copper lines.
Health outcomes 1 year after subarachnoid hemorrhage (2000)

A high proportion of long-term survivors of SAH experience ongoing deficits in high level (neuropsychological) functioning. These deficits result in impairment in social roles.
Upwind Difference Schemes for Systems of Conservation Laws - Potential Flow Equations. (1981)

We derive new upwind type finite difference approximations to systems of nonlinear hyperbolic conservation laws. The general technique is exemplified by the potential flow equations written as a first order system. The scheme has desirable properties for shock calculations. For the potential flow approximation, we show that the entropy condition is valid for limit solutions and that there exist discrete steady shocks which are unique and sharp. Numerical examples are given. (Author)
Synthesis, characterization and properties of (RE 1 x RE 0 )TiNbO 6 dielectric ceramics (2001)

Dielectric ceramics based on solid solution phases of [RE1 x RE 0 ]TiNbO6, where RE1 x D Nd, Pr, Sm and RE 0 D Dy, Gd and Y, were prepared by the conventional solid-state ceramic route for values of x. The ceramic samples are characterized by X-ray diffraction and microwave methods. Ceramics based on RE (Pr, Nd and Sm) belonging to aeschynite group shows positive value of f and those based on RE (Gd, Dy and Y) belonging to euxenite group show negative value of f . The solid solution phases between the aeschynite and the euxenite group shows intermediate dielectric constant and f values. The results indicate the possibility of tailoring the dielectric properties by varying the composition of the solid solution phases. The range of solid solubility of euxenite in aeschenite and aeschenite in euxenite are different for different rare earth ions. © 2001 Elsevier Science B.V. All rights reserved.
Novel Joint Detection and Decoding Schemes for TDMR Channels (2015)

Two-dimensional magnetic recording (TDMR) relies on advanced signal processing and coding techniques to enable storage of data at higher densities. Various detection and decoding schemes have been proposed in the literature. In this paper, a recently proposed joint detection and decoding scheme known as the joint Viterbi detector decoder (JVDD) is presented for TDMR channels. The JVDD operates on a trellis and attempts to find a sequence in the trellis that belongs to a legal codeword with minimum metric. It does so by using a metric thresholding and parity checking technique over the same trellis structure. The iterative detector/decoder consisting of a soft-output Viterbi algorithm detector and low-density parity check decoder is used as a performance benchmark for the JVDD. In this paper, we perform the comparison with various equalization/detection techniques consisting of: 1) a 1-D general partial response equalization scheme followed by a 1-D-detector as used in today's Partial Response Maximum Likelihood Detection (PRML) channels; 2) a 2-D equalization scheme that equalizes to a 1-D target [fully equalizing away the intertrack interference (ITI)], followed by a series of parallel 1-D-detectors to handle the intersymbol interference (ISI); and 3) a 2-D-equalization scheme followed by 2-D detector to combat both ITI and ISI.
Modeled methanesulfonic acid (MSA) deposition in Antarctica and its relationship to sea ice (2011)

[1] Methanesulfonic acid (MSA) has previously been measured in ice cores in Antarctica as a proxy for sea ice extent and Southern Hemisphere circulation. In a series of chemical transport model (GEOS-Chem) sensitivity experiments, we identify mechanisms that control the MSA concentrations recorded in ice cores. Sea ice is linked to MSA via dimethylsulfide (DMS), which is produced biologically in the surface ocean and known to be particularly concentrated in the sea ice zone. Given existing ocean surface DMS concentration data sets, the model does not demonstrate a strong relationship between sea ice and MSA deposition in Antarctica. The variability of DMS emissions associated with sea ice extent is small (11–30%) due to the small interannual variability of sea ice extent. Wind plays a role in the variability in DMS emissions, but its contribution relative to that of sea ice is strongly dependent on the assumed DMS concentrations in the sea ice zone. Atmospheric sulfur emitted as DMS from the sea ice undergoes net transport northward. Our model runs suggest that DMS emissions from the sea ice zone may account for 26–62% of MSA deposition at the Antarctic coast and 36–95% in inland Antarctica. Though our results are sensitive to model assumptions, it is clear that an improved understanding of both DMS concentrations and emissions from the sea ice zone are required to better assess the impact of sea ice variability on MSA deposition to Antarctica.
Absolute Quantification of Apolipoproteins Following Treatment with Omega-3 Carboxylic Acids and Fenofibrate Using a High Precision Stable Isotope-labeled Recombinant Protein Fragments Based SRM Assay (2019)

Stable isotope-labeled standard (SIS) peptides are used as internal standards in targeted proteomics to provide robust protein quantification, which is required in clinical settings. However, SIS peptides are typically added post trypsin digestion and, as the digestion efficiency can vary significantly between peptides within a protein, the accuracy and precision of the assay may be compromised. These drawbacks can be remedied by a new class of internal standards introduced by the Human Protein Atlas project, which are based on SIS recombinant protein fragments called SIS PrESTs. SIS PrESTs are added initially to the sample and SIS peptides are released on trypsin digestion. The SIS PrEST technology is promising for absolute quantification of protein biomarkers but has not previously been evaluated in a clinical setting. An automated and scalable solid phase extraction workflow for desalting and enrichment of plasma digests was established enabling simultaneous preparation of up to 96 samples. Robust high-precision quantification of 13 apolipoproteins was achieved using a novel multiplex SIS PrEST-based LC-SRM/MS Tier 2 assay in non-depleted human plasma. The assay exhibited inter-day coefficients of variation between 1.5% and 14.5% (median = 3.5%) and was subsequently used to investigate the effects of omega-3 carboxylic acids (OM3-CA) and fenofibrate on these 13 apolipoproteins in human plasma samples from a randomized placebo-controlled trial, EFFECT I (NCT02354976). No significant changes were observed in the OM3-CA arm, whereas treatment with fenofibrate significantly increased apoAII and reduced apoB, apoCI, apoE and apoCIV levels. The reduction in apoCIV following fenofibrate treatment is a novel finding. The study demonstrates that SIS PrESTs can facilitate the generation of robust multiplexed biomarker Tier 2 assays for absolute quantification of proteins in clinical studies.