gebhart/patrepeval huggingface dataset:
SiP integration of intelligent, adaptive, self-sustaining power management solutions for portable applications (2006)

Power management is an essential component of any electrical system, and nowadays a limiting factor in the miniaturization of portable electronic devices. Not only are the battery and power components difficult to integrate but their performance requirements in mobile environments are more stringent. And although point-of-load (PoL) regulation techniques and monolithic controllers are industry standards today, more integration is indispensable. To address these issues, system-in-package (SiP) self-renewable energy source and storage devices are proposed alongside an array of circuit techniques designed to circumvent the shortcomings of such a miniaturized environment, like smart load-sharing schemes, customizable and self-adaptive PoL regulators, active inductor and capacitor multipliers, and robust self-calibrating and self-stabilizing dc-dc converters. On their own, each seeks to push the limits of integration while maintaining and many times improving performance. As a whole, they promise the birth of a new generation of ICs.
Preoperative AminoIndex Cancer Screening (AICS) abnormalities predict postoperative recurrence in patients undergoing curative resection for non-small cell lung cancer (2020)

Abstract [Background] AminoIndex TM Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed of PFAA, the probability of lung cancer was categorized into AICS (lung) ranks A, B, and C in order of increasing risk. The aim of the present study was to investigate the relationship between the preoperative AICS (lung) rank and surgical outcomes in patients who underwent curative resection for non-small cell lung cancer (NSCLC). [Methods] Preoperative blood samples were collected from 297 patients who underwent curative resection for NSCLC between 2006 and 2015. PFAA concentrations were measured. The relationship between the preoperative AICS (lung) rank and clinicopathological factors was examined. The effects of the preoperative AICS (lung) rank on postoperative outcomes were also analyzed. [Results] The AICS (lung) rank was A in 93 patients (31.3%), B in 82 (27.6%), and C in 122 (41.1%). The AICS (lung) rank did not correlate with any clinicopathological factors, except for age. Based on follow-up data (median follow-up period of 6 years), postoperative recurrence was observed in 22 rank A patients (23.7%), 15 rank B (18.3%) and 49 rank C (40.2%). In the univariate analysis, preoperative AICS (lung) rank C was a worse factor of recurrence-free survival (p=0.0002). The multivariate analysis identified preoperative AICS (lung) rank C (HR: 2.17, p=0.0005) as a significant predictor of postoperative recurrence, particularly in patients with early-stage disease or adenocarcinoma. [Conclusion] Preoperative AICS (lung) rank C is a high-risk predictor of postoperative recurrence in patients undergoing curative resection for NSCLC.
Polymer Materials for Progress of PEFC (2003)

電解質膜はPEFCのキーマテリアルである。イオン伝導性だけでなく,電極触媒の活性に大きな影響を与えてPEFCの性能を左右するNafionの開発とNafionを低級アルコールに溶かした溶液の開発は燃料電池の開発の中で大きなブレークスルーをもたらした。自動車用,家庭用として大規模にPEFCが普及するためにはイオン導電性,耐熱性,化学的安定性,機械的強度のさらなる向上などに加えて,大幅なコストダウンが望まれる。
A Face Annotation Framework with Partial Clustering and Interactive Labeling (2007)

Face annotation technology is important for a photo management system. In this paper, we propose a novel interactive face annotation framework combining unsupervised and interactive learning. There are two main contributions in our framework. In the unsupervised stage, a partial clustering algorithm is proposed to find the most evident clusters instead of grouping all instances into clusters, which leads to a good initial labeling for later user interaction. In the interactive stage, an efficient labeling procedure based on minimization of both global system uncertainty and estimated number of user operations is proposed to reduce user interaction as much as possible. Experimental results show that the proposed annotation framework can significantly reduce the face annotation workload and is superior to existing solutions in the literature.
In vivo bone biocompatibility and degradation of porous fumarate‐based polymer/alumoxane nanocomposites for bone tissue engineering (2009)

The objective of this study was to determine how the incorporation of surface-modified alumoxane nanoparticles into a biodegradable fumarate-based polymer affects in vivo bone biocompatibility (characterized by direct bone contact and bone ingrowth) and in vivo degradability. Porous scaffolds were fabricated from four materials: poly(propylene fumarate)/propylene fumarate-diacrylate (PPF/PF-DA) polymer alone; a macrocomposite consisting of PPF/PF-DA polymer with boehmite microparticles; a nanocomposite composed of PPF/PF-DA polymer and mechanically reinforcing surface-modified alumoxane nanoparticles; and a low-molecular weight PPF polymer alone (tested as a degradation control). Scaffolds were implanted in the lateral femoral condyle of adult goats for 12 weeks and evaluated by micro-computed tomography and histological analysis. For all material groups, small amounts of bone, some soft tissue, and a few inflammatory elements were observed within the pores of scaffolds, though many pores remained empty or filled with fluid only. Direct contact between scaffolds and surrounding bone tissue was also observed in all scaffold types, though less commonly. Minimal in vivo degradation occurred during the 12 weeks of implantation in all materials except the degradation control. These results demonstrate that the incorporation of alumoxane nanoparticles into porous PPF/PF-DA scaffolds does not significantly alter in vivo bone biocompatibility or degradation.
Combination therapy of Tocilizumab and steroid for management of COVID-19 associated cytokine release syndrome (2021)

Cytokine release syndrome (CRS) or cytokine storm is thought to be the cause of inflammatory lung damage, worsening pneumonia and death in patients with COVID-19. Steroids (Methylprednislone or Dexamethasone) and Tocilizumab (TCZ), an interleukin-6 receptor antagonist, are approved for treatment of CRS in India. The aim of this study was to evaluate the efficacy and safety of combination therapy of TCZ and steroid in COVID-19 associated CRS.This retrospective cohort study was conducted at Noble hospital and Research Centre (NHRC), Pune, India between April 2 and November 2, 2020. All patients administered TCZ and steroids during this period were included. The primary endpoint was incidence of all cause mortality. Secondary outcomes studied were need for mechanical ventilation and incidence of systemic and infectious complications. Baseline and time dependent risk factors significantly associated with death were identified by Relative risk estimation.Out of 2831 admitted patients, 515 (24.3% females) were administered TCZ and steroids. There were 135 deaths (26.2%), while 380 patients (73.8%) had clinical improvement. Mechanical ventilation was required in 242 (47%) patients. Of these, 44.2% (107/242) recovered and were weaned off the ventilator. Thirty seven percent patients were managed in wards and did not need intensive care unit (ICU) admission. Infectious complications like hospital acquired pneumonia, blood stream bacterial and fungal infections were observed in 2.13%, 2.13% and 0.06% patients respectively. Age ≥ 60 years (P = .014), presence of co-morbidities like hypertension (P = .011), IL-6 ≥ 100 pg/ml (P = .002), D-dimer ≥ 1000 ng/ml (P < .0001), CT severity index ≥ 18 (P < .0001) and systemic complications like lung fibrosis (P = .019), cardiac arrhythmia (P < .0001), hypotension (P < .0001) and encephalopathy (P < .0001) were associated with increased risk of death.Combination therapy of TCZ and steroids is likely to be safe and effective in management of COVID-19 associated cytokine release syndrome. Efficacy of this anti-inflammatory combination therapy needs to be validated in randomized controlled trials.
Dynamic association in IEEE 802.11 based wireless mesh networks (2009)

In this paper, we propose a dynamic association mechanism that takes load balancing, link quality and association oscillation avoidance into consideration. The metric introduced in this association mechanism measures the real-time traffic load through channel based load detection and suits both coordinated and uncoordinated wireless mesh networks. Because of the random characteristics of wireless links and the variability of network conditions, dynamic re-association should be involved. To avoid association oscillation during re-associations, we introduce oscillation avoidance schemes, which consist of periodic client station (STA) scan and re-association threshold. We further evaluate our dynamic association mechanism through simulations in the context of IEEE 802.11 based wireless mesh networks.
True Random Number Generator With a Metastability-Based Quality Control (2008)

We present a metastability-based true random number generator that achieves high entropy and passes NIST randomness tests. The generator grades the probability of randomness regardless of the output bit value by measuring the metastable resolution time. The system determines the original random noise level at the time of metastability and tunes itself to achieve a high probability of randomness. Dynamic control enables the system to respond to deterministic noise and a qualifier module grades the individual metastable events to produce a high-entropy random bit-stream. The grading module allows the user to trade off output bit-rate with the quality of the bit-stream. A fully integrated true random number generator was fabricated in a 0.13 mum bulk CMOS technology with an area of 0.145 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
A Review of Structural and Biomechanical Changes in the Cornea in Aging, Disease, and Photochemical Crosslinking (2019)

The study of corneal biomechanics is motivated by the tight relationship between biomechanical properties and visual function within the ocular system. For instance, variation in collagen fibril alignment and non-enzymatic crosslinks rank high among structural factors which give rise to the cornea's particular shape and ability to properly focus light. Gradation in these and other factors engender biomechanical changes which can be quantified by a wide variety of techniques. This review summarizes what is known about both the changes in corneal structure and associated changes in corneal biomechanical properties in aging, keratoconic, and photochemically crosslinked corneas. In addition, methods for measuring corneal biomechanics are discussed and the topics are related to both clinical studies and biomechanical modeling simulations.
Supplementary Table 2 from A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell Surface (2023)

&lt;p&gt;PDF file - 57K, The number of mesothelin sites per cell on cancer cell lines.&lt;/p&gt;
Ecological and Physiological Characterization of Humicola marvinii, a New Psychrophilic Fungus from Fellfield Soils in the Maritime Antarctic (1997)

Fungi were isolated from fellfield soils at Signy Island (60° 43′ S, 45° 38′ W) in the maritime Antarctic between December 1994 and February 1995 in order to study their role in colonization processes. A psychrophilic species of Humicola was isolated that differs physiologically and morphologically from Humicola fuscoatra, to which it bears a resemblance. Based on these characteristics it is described herein as a new species, Humicola marvinii.
Multimer Formation and Ligand Recognition by the Long Pentraxin PTX3 (1997)

PTX3 is a prototypic long pentraxin consisting of a C-terminal 203-amino acid pentraxin-like domain coupled with an N-terminal 178-amino acid unrelated portion. The present study was designed to characterize the structure and ligand binding properties of human PTX3, in comparison with the classical pentraxins C-reactive protein and serum amyloid P component. Sequencing of Chinese hamster ovary cell-expressed PTX3 revealed that the mature secreted protein starts at residue 18 (Glu). Lectin binding and treatment with N-glycosidase F showed that PTX3 is N-glycosylated, sugars accounting for 5 kDa of the monomer mass (45 kDa). Circular dichroism analysis indicated that the protein consists predominantly of beta-sheets with a minor alpha-helical component. While in gel filtration the protein is eluted with a molecular mass of congruent with900 kDa, gel electrophoresis using nondenaturing, nonreducing conditions revealed that PTX3 forms multimers predominantly of 440 kDa apparent molecular mass, corresponding to decamers, and that disulfide bonds are required for multimer formation. The ligand binding properties of PTX3 were then examined. As predicted based on modeling, inductive coupled plasma/atomic emission spectroscopy showed that PTX3 does not have coordinated Ca2+. Unlike the classical pentraxins CRP and SAP, PTX3 did not bind phosphoethanolamine, phosphocholine, or high pyruvate agarose. PTX3 in solution, bound to immobilized C1q, but not C1s, and, reciprocally, C1q bound to immobilized PTX3. Binding of PTX3 to C1q is specific and saturable with a Kd 7.4 x 10(-8) M as determined by solid phase binding assay. The Chinese hamster ovary cell-expressed pentraxin domain bound C1q when multimerized. Thus, as predicted on the basis of computer modeling, the prototypic long pentraxin PTX3 forms multimers, which differ from those formed by classical pentraxins in terms of protomer composition and requirement for disulfide bonds, and does not recognize CRP/SAP ligands. The capacity to bind C1q, mediated by the pentraxin domain, is consistent with the view that PTX3, produced in tissues by endothelial cells or macrophages in response to interleukin-1 and tumor necrosis factor, may act as a local regulator of innate immunity.
Dual-Luminescence Imaging and Particle Tracking Velocimetry for Simultaneous Temperature and Velocity Field Measurements in Hydrocarbons Liquid (2021)

Abstract Arctic oil spills are particularly detrimental as they could cause extensive ice melting in addition to the environmental pollution they create. Floating oil slicks amongst ice floes absorb ambient energy and transfer that energy to the ice to aggravate melting in the thaw season. However, few studies have been undertaken to reveal how oil-ice interactions impact ice melting. This research employs a measurement technique to investigate the heat transfer pathways from oil slicks to the ice. Dual-luminescence imaging and particle imaging velocimetry (PIV) in a side cooled cavity is performed for temperature and velocity measurements of Toluene, respectively. Dual-luminescence imaging captured the spatial temperature distribution of the fuel. Consecutive imaging of the seeding particles in PIV provided the spatial velocity field of the fuel in the cavity. The results show that the convective field is directly coupled with the temperature field, i.e., the temperature difference instigates a flow in the liquid. Successful implementation of the two measuring techniques together is a step toward analyzing heat transfer pathways in a liquid fuel adjacent to an ice body, indicating the extent of melting.
Hormonal Effects of Gonadotropin-Releasing Hormone (GnRH) Agonist in the Human Male. III. Effects of Long Term Combined Treatment with GnRH Agonist and Androgen* (1985)

Chronic treatment with agonist analogs of GnRH results in reversible oligospermia in man, but leads to impotence and decreased libido due to a concomitant fall in serum testosterone (T) concentrations. We, therefore, assessed the effects of combined treatment with a potent GnRH agonist and T on gonadotropins and spermatogenesis in normal men, anticipating that addition of androgen would prevent agonist-induced changes in libido. Seven normal men were treated with 200 micrograms of the GnRH agonist D-(Nal2)6GnRH (GnRH-A), sc, daily for 16 weeks. In addition, 200 mg T enanthate were administered every 2 weeks for the entire 16-week treatment period. Basal LH, FSH, and T concentrations were measured every week during a 5-week control period, daily on treatment days 0, 1-10, 14, 18, 22, 26, and 28, every week thereafter until day 56, and every 2 weeks thereafter for the remainder of the treatment and recovery phases. Detailed analysis of LH and FSH over the 24-h period was performed by multiple blood sampling on days 0, 1, 10, 28, 56, 84, and 112. Semen analyses were performed every week during the control phase and every 2 weeks during the treatment and recovery phases. The mean sperm count declined by 83%, to a nadir of 16.6 +/- 6.2 (+/- SEM) million/ml. One subject had no significant decrease in sperm count. Azoospermia was not achieved in any subject. Basal serum LH concentrations, after an early phase of stimulation, declined to near baseline by day 14. However, basal, 24-h integrated serum LH concentrations, and 24-h urinary LH excretion were not significantly lowered by combined treatment. Bioassayable serum LH concentrations, however, declined significantly from 20.4 +/- 6.3 to 4.5 +/- 0.5 mIU/ml, and the bioassayable to immunoassayable LH ratio decreased from 2.1 +/- 1.0 to 0.7 +/- 0.1 after 16 weeks of GnRH-A treatment. Basal and 24-h integrated FSH concentrations, after an initial period of stimulation, declined progressively to baseline by days 5-6 and were significantly below baseline by day 112. Serum T concentrations did not fall into the hypogonadal (less than 250 ng/dl) range in any subject at any time during the treatment period. After discontinuation of treatment, LH, FSH, and sperm counts returned to normal in all subjects. Thus, single daily injection of GnRH-A and T failed to predictably induce azoospermia in normal men over the 16-week treatment period.(ABSTRACT TRUNCATED AT 400 WORDS)
Bibliographie (2000)

1 - ARCHIVES DE PARIS 1.1. Exposition Coloniale de 1931 Dix-huit cartons relatifs à l’exposition coloniale 1931 10625/52/1. n° 2 - Budget 1927, 1928-1930, 1931, 1932. n° 4 - Concessions - Etablissement du plan général de l’exposition, - Délimitation des concessions, - Réglementation des concessions, - Procédure d’instruction des demandes. n° 6 - Démolition des bâtiments et remise en état des terrains, - Plans de remise en état. Modalités de remise en état, - Décision de la 3e commission du Co...
Glial cell line-derived neurotrophic factor in bone marrow stromal cells of rat (2005)

To investigate the capability of Sprague-Dawley rat bone marrow stromal cells to secrete glial cell line-derived neurotrophic factors (GDNF), we detected expression of GDNF messenger RNA and protein in bone marrow stromal cells of Sprague-Dawley rats by reverse-transcriptase polymerase chain reaction and enzyme-linked immunosorbent assay (ELISA), respectively. The GDNF messenger RNA and protein were detected in culture medium and total cell protein when bone marrow stromal cells were cultured for 3 days. The levels of GDNF in culture medium and total cell protein increased gradually after 3, 7 and 10 days of culture. Rat bone marrow stromal cells have the potential to secrete GDNF. Furthermore, the ability of secretion is determined by the surrounding microenvironment and self-growth status.
Celebrating PELS Day Around the World [Society News] (2019)

Reports on the activities and events that were part of PELS Day.
In Vitro Effects of the Reduced Form of Coenzyme Q10 on Secretion Levels of TNF-α and Chemokines in Response to LPS in the Human Monocytic Cell Line THP-1 (2009)

Ubiquinol-10 (QH(2)), the reduced form of Coenzyme Q(10) (CoQ(10)) serves as a potent antioxidant of lipid membranes. Because many antioxidants reveal potent anti-inflammatory effects, the influence of QH(2) on lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and chemokines were determined in the human monocytic cell line THP-1. Stimulation of cells with LPS resulted in a distinct release of Tumour necrosis factor-alpha (TNF-alpha), Macrophage inflammatory protein-1 alpha (MIP-1alpha), Regulated upon activation, normal T cell expressed and secreted (RANTES) and Monocyte chemotattractant protein-1 (MCP-1). The LPS-induced responses were significantly decreased by pre-incubation of cells with QH(2) to 60.27 +/- 9.3% (p = 0.0009), 48.13 +/- 6.93% (p = 0.0007) and 74.36 +/- 7.25% (p = 0.008) for TNF-alpha, MIP-1alpha and RANTES, respectively. In conclusion, our results indicate anti-inflammatory effects of the reduced form of CoQ(10) on various proinflammatory cytokines and chemokines in vitro.
Technical Note: Construction of a Low-Cost Black Globe Thermometer (2008)

An economical self-contained globe thermometer was developed for use in field applications. The instrument uses a miniature integral temperature sensor and datalogger in place of a separate sensor and external datalogger. The performance of the miniature sensor/logger units was shown to be satisfactory for use in globe thermometers. Calibration of the units showed a linear behavior with standard errors ranging from 0.02C to 0.04C for the span of 15C to 90C. The integral sensor/logger performed as well as the thermistor/external logger combination and can be fabricated at a low cost.
Les indications rares de transplantation hépatique (2021)

La transplantation hépatique est le traitement de dernier recours en cas de maladies hépatiques, aiguës (hépatite fulminante) ou chroniques, à un stade terminal, en l’absence de contre-indication, qui sont devenues de plus en plus limitées, liées souvent à l’âge. Les principales indications de transplantation hépatique sont les cirrhoses, avec insuffisance hépatique, complications de l’hypertension portale et/ou carcinome hépatocellulaire. Les maladies hépatiques chroniques le plus souvent responsables sont la maladie du foie liée à l’alcool, les hépatites virales et la stéatopathie métabolique, avec de grandes variations dans le monde. La maladie conduisant le plus souvent à la transplantation hépatique en France (actuellement environ 1 300 transplantations hépatiques par an) est la maladie du foie liée à l’alcool, représentant 40 à 50 % des cas, stable depuis de nombreuses années. Le but de cet article est de faire un point, à l’opposé, sur les causes rares de maladie hépatique pouvant faire discuter et indiquer la transplantation hépatique et ainsi de fournir les bases nécessaires au lecteur non spécialiste de la transplantation hépatique.
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice (2004)

Narcolepsy-cataplexy is a neurological disorder associated with the inability to maintain wakefulness and abnormal intrusions of rapid eye movement sleep-related phenomena into wakefulness such as cataplexy. The vast majority of narcoleptic-cataplectic individuals have low or undetectable levels of orexin (hypocretin) neuropeptides in the cerebrospinal fluid, likely due to specific loss of the hypothalamic orexin-producing neurons. Currently available treatments for narcolepsy are only palliative, symptom-oriented pharmacotherapies. Here, we demonstrate rescue of the narcolepsy-cataplexy phenotype of orexin neuron-ablated mice by genetic and pharmacological means. Ectopic expression of a prepro-orexin transgene in the brain completely prevented cataplectic arrests and other abnormalities of rapid eye movement sleep in the absence of endogenous orexin neurons. Central administration of orexin-A acutely suppressed cataplectic behavioral arrests and increased wakefulness for 3 h. These results indicate that orexin neuron-ablated mice retain the ability to respond to orexin neuropeptides and that a temporally regulated and spatially targeted secretion of orexins is not necessary to prevent narcoleptic symptoms. Orexin receptor agonists would be of potential value for treating human narcolepsy.