gebhart/patrepeval huggingface dataset:
Immunomodulating properties of bestatin in cancer patients. A phase II trial. (1986)

Thirty-four patients with cancer (30) or ARC (4) with severe T cell defect or imbalance persisting a long time after completion of any cytostatic treatment were treated by bestatin 30 mg/day 3 days per week during three weeks. The drug has no toxicity of any kind. Reassessment of T cell subsets after completion of bestatin therapy showed a significant improvement of the absolute number of CD4 cells in peripheral blood. CD8 subsets wether initially increased or decreased were modified towards normalisation but the modification reached statistical significance only in the subgroup with initial absolute defect of CD8 cells. CD4/CD8 ratio was significantly increased whether considering all cycles of therapy, or all those given to patients with initially high or normal CD8 subsets. Bestatin appears to have immunomodulating properties which might be useful in cancer patients.
Efficient calculation of molecular constants and transition intensities in weakly bound species from J=0 eigenstates: Benzene-Ar as test case (2001)

In application to benzene-Ar we test a procedure that makes use of conveniently calculated J=0 intermolecular eigenstates to compute molecular constants and transition intensities without requiring explicit diagonalization of the full rotational/intermolecular vibrational Hamiltonian of the species. The approach relies on the ability to calculate the orientation of an Eckart body-fixed frame for each point on a grid over which a J=0 state is represented. That ability allows one to compute vibrational matrix elements of operators referred to the Eckart axes while working with J=0 eigenstates obtained in an entirely different body-fixed frame. Generally excellent agreement is found between the Eckart results and those obtained by others via diagonalization of the full rotational/intermolecular vibrational Hamiltonian. Finally, a general prescription for the construction of an efficient rovibrational basis from J=0 solutions in a convenient body-fixed frame is presented.
MULTIRESOLUTION ANALYSIS FOR IRREGULAR MESHES WITH APPEARANCE ATTRIBUTES (2006)

We present a new multiresolution analysis framework based on the lifting scheme for irregular meshes with attributes. We introduce a surface prediction operator to compute the detail coefficients for the geometry and the attributes of the model. Attribute analysis gives appearance information to complete the geometrical analysis of the model. We present an application to adaptive visualization and some experimental results to show the efficiency of our framework.
Exploratory Study of Acoustic Neuromodulation Improves Pain, Autonomic Function, and Symptoms of Insomnia, Stress, and Anxiety in Individuals with Chronic Pain (4291) (2021)

Evaluate the impact of Cereset Research™ (CR), on pain, autonomic function, insomnia, stress, and anxiety for those with chronic pain.
Third generation wireless technologies-expectations and realities (2002)

The telecommunication industry is evolving at an unprecedented pace. As the PCS operators are just rolling out their network, the ITU (International Telecommunication Union) has already initiated the development of the third generation mobile communication standards. This paper presents an overview of the design issues and technical innovations as being developed during the process of the standard developments.
Functionally separated, multiple-valued content-addressable memory and its applications (1995)

A design of a high-density multiple-valued content-addressable memory (MVCAM) is presented. The key concept of the proposed MVCAM is a functionally separated configuration in which the cell functions are split into two basic parts: a threshold function and logic-value conversion. Complicated search operations are synthesised by the combination of these two basic functions. The circuit for logic-value conversion is designed by a binary-to-multiple-valued encoder as a peripheral circuit. Input data are encoded by the logic-value conversion and are distributed to each CAM cell. A CAM cell for performing the threshold function is simply designed using one floating-gate MOS transistor. Separating the complex search operations into the threshold function and the logic-value conversion, a simple CAM cell can be achieved. As a result, it is estimated that a 1 Mbit four-valued CAM can be implemented using conventional flash EEPROM technologies and is useful in two typical applications.
A Clear-Cut Experimental Method to Discriminate between In-Plane and Out-of-Plane Molecular Transition Moments (2005)

A new method to orient organic molecules, based on their absorption as guest of the crystalline nanoporous delta phase of uniaxially stretched syndiotactic polystyrene films, is presented. This molecular alignment method not only allows high degrees of guest orientation to be attained but also orients the planar guest molecules with their smallest cross section nearly parallel to the stretching direction (B) rather than perpendicular (A, as usual for absorption in amorphous polymeric phases). As a consequence, in-plane and out-of-plane transition moment vectors maximize their absorption intensities for light polarization nearly perpendicular and parallel to the stretching direction, respectively. Hence, simple linear dichroism measurements by polarized spectra can allow an easy and clear-cut discrimination between in-plane and out-of-plane guest transition moment vectors.
Placement of unilateral lag screw through the lateral mass of C-1: description of a novel technique (2013)

Over the past several decades, many advancements and new techniques have emerged regarding the instrumentation and stabilization of the upper cervical spine. In this article, the authors describe a novel technique in which a unilateral lag screw was placed to reduce and stabilize a progressively widening fracture and nonunion of the right C-1 lateral mass approximately 8 weeks after the initial injury, which was sustained when a large tree branch fell onto the patient's posterior head and neck.
MECHANICAL TESTING FOR GENERATING INPUT TO NUMERICAL SIMULATION OF IMPACT RESPONSE OF INJECTION-MOULDED COMPONENTS (2008)

Numerical simulation of the impact response of injection-moulded components has gained importance in several industry sectors, in particular in the automotive industry. Recent studies have demonstrated progress in model- ling special features of ductile polymers' mechanical response. However, several experimental challenges remain. Some of these will be addressed in this presentation, based on an ongoing study with polypropylene materials. Tests for high- speed uniaxial tension, uniaxial compression and shear are summarised. Work in progress is presented for tensile loading/unloading response, and for effects of injection moulding conditions on mechanical response.
An Extract of Artemisia dracunculus L. Inhibits Ubiquitin-Proteasome Activity and Preserves Skeletal Muscle Mass in a Murine Model of Diabetes (2013)

Impaired insulin signaling is a key feature of type 2 diabetes and is associated with increased ubiquitin-proteasome-dependent protein degradation in skeletal muscle. An extract of Artemisia dracunculus L. (termed PMI5011) improves insulin action by increasing insulin signaling in skeletal muscle. We sought to determine if the effect of PMI5011 on insulin signaling extends to regulation of the ubiquitin-proteasome system. C2C12 myotubes and the KK-A(y) murine model of type 2 diabetes were used to evaluate the effect of PMI5011 on steady-state levels of ubiquitylation, proteasome activity and expression of Atrogin-1 and MuRF-1, muscle-specific ubiquitin ligases that are upregulated with impaired insulin signaling. Our results show that PMI5011 inhibits proteasome activity and steady-state ubiquitylation levels in vitro and in vivo. The effect of PMI5011 is mediated by PI3K/Akt signaling and correlates with decreased expression of Atrogin-1 and MuRF-1. Under in vitro conditions of hormonal or fatty acid-induced insulin resistance, PMI5011 improves insulin signaling and reduces Atrogin-1 and MuRF-1 protein levels. In the KK-A(y) murine model of type 2 diabetes, skeletal muscle ubiquitylation and proteasome activity is inhibited and Atrogin-1 and MuRF-1 expression is decreased by PMI5011. PMI5011-mediated changes in the ubiquitin-proteasome system in vivo correlate with increased phosphorylation of Akt and FoxO3a and increased myofiber size. The changes in Atrogin-1 and MuRF-1 expression, ubiquitin-proteasome activity and myofiber size modulated by PMI5011 in the presence of insulin resistance indicate the botanical extract PMI5011 may have therapeutic potential in the preservation of muscle mass in type 2 diabetes.
Resolution of photonic crystal superprism (2002)

We theoretically investigated the performance of the photonic crystal superprism, that is, the propagating beam quality, the wavelength sensitivity, and the resolution as a narrow band filter at 1.5-μm-wavelength range. First, we defined the equi-incident-angle curve in the Brillouin zone. Next, we mapped three parameters that represented the abovementioned performance over the Brillouin zone. As a result, we found a narrow design window that allows a high resolution of 0.4 nm along an equi-incident-angle curve but requires an incident beam width of over 100 μm and a device length of centimeter order. It can be an essential high efficiency filter if the input end of the crystal is optimized and the propagation loss is suppressed.
A Deterministic Sub-linear Time Sparse Fourier Algorithm via Non-adaptive Compressed Sensing Methods (2007)

We study the problem of estimating the best B term Fourier representation for a given frequency-sparse signal (i.e., vector) $\textbf{A}$ of length $N \gg B$. More explicitly, we investigate how to deterministically identify B of the largest magnitude frequencies of $\hat{\textbf{A}}$, and estimate their coefficients, in polynomial$(B,\log N)$ time. Randomized sub-linear time algorithms which have a small (controllable) probability of failure for each processed signal exist for solving this problem. However, for failure intolerant applications such as those involving mission-critical hardware designed to process many signals over a long lifetime, deterministic algorithms with no probability of failure are highly desirable. In this paper we build on the deterministic Compressed Sensing results of Cormode and Muthukrishnan (CM) \cite{CMDetCS3,CMDetCS1,CMDetCS2} in order to develop the first known deterministic sub-linear time sparse Fourier Transform algorithm suitable for failure intolerant applications. Furthermore, in the process of developing our new Fourier algorithm, we present a simplified deterministic Compressed Sensing algorithm which improves on CM's algebraic compressibility results while simultaneously maintaining their results concerning exponential decay.
Effects of different protein plants in cows diet on milk for Parmigiano Reggiano production (2007)

Two homogeneous groups of dairy cows were fed the same base diet added with a concentrate containing 10 % of soybean meal or 10.1 % of faba bean and 10.1 % of pea. The substitution of soybean meal with faba bean + pea reduced dry matter intake (−0.83 kg/head/day equivalent to 3.5%) and milk yield (−1.29 kg/head/day equivalent to 3.9%), but increased fat and casein concentrations in milk and, as a consequence, cheese yield at 32 hours (P>0.01). The present data show that is possible feed a GMO free diet to dairy cows, without using soybean meal.
VLSI circuit synthesis using a parallel genetic algorithm (2002)

A parallel implementation of a genetic algorithm used to evolve simple analog VLSI circuits is described. The parallel computer system consisted of twenty distributed SPARC workstations whose computational activity is controlled by the parallel environment coordination language Linda. Work-in-progress on using the parallel GA to realize optimized circuits and to discover new types of equivalent-function circuits is presented. The use of biologically inspired development rules to limit the scope of circuits generated by recombination operators to circuits that have an increased chance of surviving is briefly discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Facilitating research participation and improving quality of life for African American prostate cancer survivors and their intimate partners (2006)

African American men experience worse prostate cancer outcomes compared with those of Caucasian men, not only in incidence and mortality rates, but also in coping with the side effects of treatment. Unfortunately, African American men have been significantly under-represented in research evaluating the efficacy of psychosocial interventions for improving coping in prostate cancer survivors. This pilot study explored the feasibility and efficacy of coping skills training (CST), an intervention developed to enhance coping with treatment side effects in a sample of African American prostate cancer survivors and their intimate partners. The intervention was delivered in a telephone-based format designed to facilitate research participation. A total of 40 couples were randomized to either 6 sessions of CST or usual care. Survivors completed measures of disease-specific quality of life (QOL) related to urinary, sexual, bowel, and hormonal symptom domains, as well as measures of global QOL (i.e., physical functioning and mental health). Partners completed measures of caregiver strain, mood, and vigor. Analysis of data from 30 couples (12 couples in CST, 18 couples in usual care) indicated that CST produced moderate to large treatment effects for QOL related to bowel, urinary, sexual, and hormonal symptoms. Partners who underwent CST reported less caregiver strain, depression, and fatigue, and more vigor, with moderate effect sizes observed that approached conventional levels of statistical significance. These preliminary findings suggest that telephone-based CST is a feasible approach that can successfully enhance coping inAfrican American prostate cancer survivors and their intimate partners. Cancer 2007. (c) 2006 American Cancer Society.
Development of natural gas injection technology for NO sub x reduction from municipal waste combustors (1991)

Natural gas injection (NGI) technology for reducing NO{sub x} emissions from municipal waste combustors (MWCs) is being developed. The approach involves the injection of natural gas, together with recirculated flue gases (for mixing), above the grate to provide reducing combustion conditions that promote the destruction of NO{sub x} precursors, as well as NO{sub x}. Extensive development testing was subsequently carried out in a 2.5 {times} 10{sup 6} Btu/h (0.7 MWth) pilot-scale MWC firing actual MSW. Both tests, using simulated combustion products and actual MSW, showed that 50% to 70% NO{sub x} reduction could be achieved. These results were used to define the key operating parameters. A full-scale system has been designed and retrofitted to a 100-ton/day Riley/Takuma mass burn system at the Olmsted County Waste-to-Energy facility. The system was designed to provide variation in the key parameters to not only optimize the process for the Olmsted unit, but also to acquire design data for MWCs of other sizes and designs. Extensive testing was conducted to December 1990 and January 1991 to evaluate the effectiveness of NGI. This paper concentrates on the METHANE de-NO{sub x} system retrofit and testing. The results show simultaneous reductions of 60% in NO{sub x}, 50% in CO, and 40% in excess air requirement with natural gas injection. 4 refs., 5 figs., 1 tab.
Synthesis of arylsulfonyl substituted pyrroles (1987)

Abstract The cycloaddition reaction of symmetrically and unsymmetrically substituted munchnones with arylsulfonyl alkynes has been studied. The reaction affords pyrrole derivatives whose structures were assigned on the basis of spectroscopic data. The distribution of regioisomers observed in the case of unsymmetrically substituted munchnones is discussed.
An efficient broadcast authentication scheme in wireless sensor networks (2006)

A broadcast authentication mechanism is important in wireless sensor networks, assuring receivers of a packet's validity. To provide authentication, some researchers utilize one way key chains and delayed disclosure of keys; however, such an approach requires time synchronization and delayed authentication. Another technique uses one-time signature schemes. Unfortunately, such schemes suffer from large key sizes and a limited number of uses per key. To cope with these problems, we propose an efficient, one-time signature-based broadcast authentication scheme for wireless sensor networks that reduces storage usage and includes a re-keying mechanism.
Load Balanced Controller Association in Wireless Distributed SDNs (2020)

Wireless infrastructure is steadily evolving into wireless access for all humans and most devices, from 5G to Internet-of-Things. This widespread access creates the expectation of custom and adaptive services from the personal network to the backbone network. In addition, challenges of scale and interoperability exist across networks, applications and services, requiring an effective wireless network management infrastructure. For this reason Software-Defined Networks (SDN) have become an attractive research area for wireless and mobile systems. SDN can respond to sporadic topology issues such as dropped packets, message latency, and/or conflicting resource management, to improved collaboration between mobile access points, reduced interference and increased security options. Until recently, the main focus on wireless SDN has been a more centralized approach, which has issues with scalability, fault tolerance, and security. In this work, we propose a state of the art WAM-SDN system for large-scale network management. We discuss requirements for large scale wireless distributed WAM-SDN and provide preliminary benchmarking and performance analysis based on our hybrid distributed and decentralized architecture.
Metabolism of diltiazem. II. Metabolic profile in rat, dog and man. (1988)

The metabolism of diltiazem was studied in male rats and dogs after intravenous administration of 14C-diltiazem.HCl or in men after oral administration of a tablet of diltiazem.HCl. The main metabolites in rat urine, in decreasing order of content, were A4, M6, M4 and M5. The unchanged drug in the urine accounted for only 0.7% of the administered drug based on radioactivity. About 81% of biliary radioactivity in rat was due to water-soluble metabolites and the remainder was mostly acidic metabolites such as A4 and A6. In dog urine, the unchanged drug was most abundant (30.6% of the radioactivity in the 6-h urine), followed by A2, A1 and M2. The main metabolites of diltiazem in rat plasma were A2 and A4, while in dog plasma, the unchanged drug and A2 were found as main components. In human urine, M4, the unchanged drug, A2, MB, MD and M2 were the major components. Acidic metabolites, A1-A4, were found also in human plasma and A2 was the main metabolite found. These results indicated that the main metabolic pathway of diltiazem was an oxidative deamination which is extensive in the rat. Other metabolic pathways recognized in this study were oxidative demethylation, deacetylation, hydroxylation of the aromatic ring and conjugation. Although direct comparison may not be appropriate because of the different routes of administration, the metabolism of diltiazem in man appears to be more similar to that in the dog than that in the rat.
Novel mutations and DNA-based screening in non-Jewish carriers of Tay-Sachs disease. (1997)

We have evaluated the feasibility of using PCR-based mutation screening for non-Jewish enzyme-defined carriers identified through Tay-Sachs disease-prevention programs. Although Tay-Sachs mutations are rare in the general population, non-Jewish individuals may be screened as spouses of Jewish carriers or as relatives of probands. In order to define a panel of alleles that might account for the majority of mutations in non-Jewish carriers, we investigated 26 independent alleles from 20 obligate carriers and 3 affected individuals. Eighteen alleles were represented by 12 previously identified mutations, 7 that were newly identified, and 1 that remains unidentified. We then investigated 46 enzyme-defined carrier alleles: 19 were pseudodeficiency alleles, and five mutations accounted for 15 other alleles. An eighth new mutation was detected among enzyme-defined carriers. Eleven alleles remain unidentified, despite the testing for 23 alleles. Some may represent false positives for the enzyme test. Our results indicate that predominant mutations, other than the two pseudodeficiency alleles (739C-->T and 745C-->T) and one disease allele (IVS9+1G-->A), do not occur in the general population. This suggests that it is not possible to define a collection of mutations that could identify an overwhelming majority of the alleles in non-Jews who may require Tay-Sachs carrier screening. We conclude that determination of carrier status by DNA analysis alone is inefficient because of the large proportion of rare alleles. Notwithstanding the possibility of false positives inherent to enzyme screening, this method remains an essential component of carrier screening in non-Jews. DNA screening can be best used as an adjunct to enzyme testing to exclude known HEXA pseudodeficiency alleles, the IVS9+1G-->A disease allele, and other mutations relevant to the subject's genetic heritage.
Quantifying displacement of urogenital organs after abdominoperineal resection for rectal cancer (2021)

Substantial absolute displacement and rotation of urogenital organs after APR for rectal cancer were observed, but with high variability among both men and women, and being significantly associated with reconstructive interventions.
Idiopathic Interstitial Pneumonia (2007)

Significant disagreement exists in the diagnosis of DPLD between physicians based in communities compared with those in academic centers. Wherever possible, patients should be referred to centers with expertise in diffuse parenchymal lung disorders to help clarify the diagnosis and provide suggestions regarding treatment options.
Biosynthetic Origins of the Natural Product, Thiolactomycin:  A Unique and Selective Inhibitor of Type II Dissociated Fatty Acid Synthases (2003)

Thiolactomycin (TLM), a natural product produced by both Nocardia and Streptomyces spp., is a potent and highly selective inhibitor of the type II dissociated fatty acid synthases of plants and bacteria. The unique mode of action of TLM and its low toxicity make it an attractive compound for development of new antimicrobial agents. In this study, incorporation studies with 13C-labeled precursors demonstrate that TLM is derived from one acetate-derived starter unit and three methylmalonate-derived extender units. The unusual thiolactone represented by TLM represents a novel class of polyketide-derived antibiotics in which an unusual cyclization process, which terminates the biosynthetic pathway, involves incorporation of a sulfur atom from l-cysteine. Manipulation of this pathway through techniques such a combinatorial biosynthesis and mutasynthesis may provide a new route for economically viable production of useful TLM analogues.