gebhart/patrepeval huggingface dataset:
Classification with automatic detection of unknown classes based on SVM and fuzzy MBF: Application to motor diagnosis (2018)

Classification algorithms based on data mining tools show good performances for the automatic diagnosis of systems. However, these performances degrade quickly when the database is not exhaustive. This happens, for example, when a new class appears. This class could correspond to a previous unknown fault or to an unknown combination of simultaneous faults. Described algorithm in this paper proposes a solution to this issue. It combines Support Vector Machine (SVM), fuzzy membership functions (mbf) and fuzzy information fusion. It results in the construction of a matrix of memberships to known classes U_class and a vector of membership to unknown classes U_others. Then, from these values, indicators of distance and ambiguity of the observations can be computed. These indicators allow setting a simple rejection rule with a threshold classifier. The algorithm is validated by using Cross-Validation (CV) on experimental data on an induction motor faults supplied by a voltage-source inverter. The results show the good performances of the proposed algorithms and its suitability for transportation systems like aircrafts.
Interference mitigation techniques for narrowband powerline smart grid communications (2015)

Narrowband cyclostationary interference severely limits the performance of power line communications (PLC) on low-voltage in the [3-500] kHz frequency band. For the IEEE 1901.2 narrowband PLC standard system parameters, this interference is not sparse in the time or the frequency domains making recently-proposed sparse interference mitigation techniques ineffective. In this paper, we investigate other properties of the interference; namely, its cyclostationarity and high spatial correlation across the three output phases to design effective and practical interference mitigation algorithms. The cyclostationarity is exploited to accurately estimate the interference's power spectral density in each of its three temporal regions and use it to enhance the Viterbi and/or Reed-Solomon decoder performance. The high spatial correlation is exploited to mitigate interference effects through cancellation or erasure decoding. Simulation results show considerable performance gains for both techniques.
Modeling and Mitigation of Extra-SoC Thermal Coupling Effects and Heat Transfer Variations in Mobile Devices (2015)

In smartphones and tablets, a number of components, such as display and communication subsystem, dissipate a significant amount of heat. This influences the SoC thermal envelope, because of the absence of a fan. Thus the thermal conditions of the SoC cannot simply be modeled as only a function of the SoC component power. In addition, contact surfaces and phone orientation variations (e.g., phone inside a pocket, phone held in a hand, and phone laying on a desk) change the heat transfer coefficients of the device over time and influence the SoC temperature. In this work, we analyze the thermal behavior of a commercial mobile device in varying user interaction profiles and under different environmental conditions. Next, we propose a system-variation aware thermal modeling strategy that only uses available power and thermal sensors. Lastly, we devise a novel ambient-aware proactive thermal management algorithm. Our approach is able to meet the given thermal constraints while providing stable performance and comparable power consumption with respect to existing techniques. In contrast, the state-of-the-art approaches, which do not consider ambient condition variations, violate the thermal constraints and lead up to 2.6× higher performance variations.
Light regulation of metabolic pathways in fungi (2009)

Light represents a major carrier of information in nature. The molecular machineries translating its electromagnetic energy (photons) into the chemical language of cells transmit vital signals for adjustment of virtually every living organism to its habitat. Fungi react to illumination in various ways, and we found that they initiate considerable adaptations in their metabolic pathways upon growth in light or after perception of a light pulse. Alterations in response to light have predominantly been observed in carotenoid metabolism, polysaccharide and carbohydrate metabolism, fatty acid metabolism, nucleotide and nucleoside metabolism, and in regulation of production of secondary metabolites. Transcription of genes is initiated within minutes, abundance and activity of metabolic enzymes are adjusted, and subsequently, levels of metabolites are altered to cope with the harmful effects of light or to prepare for reproduction, which is dependent on light in many cases. This review aims to give an overview on metabolic pathways impacted by light and to illustrate the physiological significance of light for fungi. We provide a basis for assessment whether a given metabolic pathway might be subject to regulation by light and how these properties can be exploited for improvement of biotechnological processes.
Evaluation of Fluorapatite as a Waste-Form Material: Fourth Quarter Report, June 1 - September 30, 2004 (2004)

Fluorapatite, fluorinated calcium phosphate, has been identified as a potential matrix for the entombment of the zirconium fluoride fission product waste stream from the proposed FLEX process. If the efficacy of fluorapatite-based waste-storage can be demonstrated, then new and potentially more-efficient options for handling and separating high-level wastes, based on fluoride-salt extraction, will become feasible. This proposal will develop a dual-path research project to develop a process to fabricate a synthetic fluorapatite waste form for the ZrF4, FP waste stream, characterize the waste form, examine its performance under environmental conditions, and correlate the behavior of the waste form with natural analogs. Characterization of the material will be accomplished through probing the molecular-scale electronic and geometric structure of the materials in order to relate them to macroscopic properties, with the goal of developing techniques to evaluate and predict the performance of different waste-form materials. Time and funding permitting, other waste forms for the zirconium fluoride, fission product salt waste stream will be examined and benchmarked against the fluorapatite matrix baseline.\nHighlights of Accomplishments:\n1. Fluorapatite containing Sr and Zn surrogates (replacing the Ca) have been synthesized, annealed and analyzed using various techniques such as SEM, IR, XPS, Raman, DSC, TGA, EDS, XRD and XANES.\n2. Non-annealed samples of the same surrogate samples have been analyzed with the same techniques.\n3. The phosphate in fluorapatite and hydroxyapatite is not replaced by the nitrate ions of the surrogates during synthesis.
TD-1792 versus Vancomycin for Treatment of Complicated Skin and Skin Structure Infections (2012)

TD-1792 is a first-in-class glycopeptide-cephalosporin heterodimer that exhibits bactericidal activity against Gram-positive pathogens. We conducted a randomized, double-blind, active-control, phase II trial in patients with complicated skin and skin structure infections caused by suspected or confirmed Gram-positive organisms. Patients 18 to 65 years old were randomized to receive 7 to 14 days of either TD-1792 (2 mg/kg of body weight intravenously [i.v.] every 24 h [q24h]) or vancomycin (1 g i.v. q12h, with dosage regimens adjusted per site-specific procedures). A total of 197 patients were randomized and received at least one dose of study medication. Rates of clinical success at the test-of-cure evaluation were similar in all analysis populations. Among 170 clinically evaluable patients, cure rates were 91.7% and 90.7% in the TD-1792 and vancomycin groups, respectively (95% confidence interval [CI] of -7.9 to 9.7 for the difference). In microbiologically evaluable patients with methicillin-resistant Staphylococcus aureus at baseline (n = 75), cure rates were 94.7% in the TD-1792 group and 91.9% in the vancomycin group. Microbiological eradication of Gram-positive pathogens (n = 126) was achieved in 93.7% and 92.1% of patients in the TD-1792 and vancomycin groups, respectively. Seven patients were discontinued from study medication due to an adverse event (AE): 2 and 5 in the TD-1792 and vancomycin groups, respectively. AEs were of similar types and severities between the two groups, other than pruritus, which was more common in patients who received vancomycin. No patients in the TD-1792 group experienced a serious AE. This study supports further clinical development of TD-1792 in patients with Gram-positive infection.
Interoperability for mobile agents by incarnation agents (2003)

Many different kinds of mobile agent platforms have been developed. However, migration to a different type of mobile agent platform is actually impossible. As a solution to this problem, we propose an interoperability concept using incarnation agents. This concept realizes logical mobility between different kinds of agent platforms. The incarnation agent extracts an agent's procedures and status, compiles them into an agent platform-independent format, and then re-compiles them to the target agent platform format, thus enabling the process to continue. The incarnation agent also has autonomy for interoperability. It manages complex migration for interoperability so that the agent's procedures can be described in a simple mobile model. Moreover, the incarnation agent modifies the agent's procedures so that they are applicable to the facilities of the target agent platform. Feasibility experiments using interoperability middleware have been conducted as a basis for realizing incarnation agents.
Metadata analysis of knowledge management in supply chain (2016)

Purpose – The purpose of this paper is to present a comprehensive and useful insight into the knowledge management (KM) in the supply chain (SC) research and provide gaps and future research implications. The literature review includes a metadata analysis of KM in SC research along a number of dimensions, the existing dimensions as well as dimensions which are previously not been presented within the current area to predict the future role of KM in SC. Design/methodology/approach – The study is to examine the status of KM in SC within academic and industrial research in the last 14 years. The systematic literature review of KM in SC is based on 176 peer reviewed articles selected through a multi-stage process, from 1,063 studies during January 2001-June 2014. Findings – An increase in the interest level of incorporating KM in SC is clearly visible while studying available literature. The statistics prove that research in the field of KM in SC is overwhelmingly empirically oriented. Another major finding shows that the survey model score highest among all the research method used in the discipline. In general, the research is more interpretive in nature and provides a frame for theoretical critique. The result indicates that there is a need to use of advanced data analysis techniques with traditional data analysis technique. Originality/value – The review simply provides statistical summary which is easy to understand for practitioner and provide increased insights on the current state of research for the KM in SC.
Effects of tunneling on groundwater flow and swelling of clay-sulfate rocks (2011)

[1] Swelling of clay-sulfate rocks is a major threat in tunneling. It is triggered by the transformation of the sulfate mineral anhydrite into gypsum as a result of water inflow in anhydrite-containing layers after tunnel excavation. The present study investigates the hydraulic effects of tunneling on groundwater flow and analyzes how hydraulic changes caused by excavation lead to water inflow into anhydrite-containing layers in the tunnel area. Numerical groundwater models are used to conduct scenario simulations that allow one to relate hydrogeological conditions to rock swelling. The influence of the topographic setting, the excavation-damaged zone around the tunnel, the sealing effect of the tunnel liner, and the geological configuration are analyzed separately. The analysis is performed for synthetic situations and is complemented by a case study from a tunnel in Switzerland. The results illustrate the importance of geological and hydraulic information when assessing the risk of swelling at an actual site.
Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research (2023)

Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications. Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension cells are generally utilized because they are easy to culture and tend to produce proteins in high yield. However, some proteins purified from CHO cell overexpression suffer from clipping and display undesired non-human post translational modifications (PTMs). In addition, CHO cell lines are often not suitable for producing proteins with many glycosylation motifs for structural biology studies, as N-linked glycosylation of proteins poses challenges for structure determination by X-ray crystallography. Hence, alternative and complementary cell lines are required to address these issues. Here, we present a robust method for expressing proteins in human embryonic kidney 293 (HEK293)-derived stable pools, leading to recombinant protein products with much less clipped species compared to those expressed in CHO cells and with higher yield compared to those expressed in transiently-transfected HEK293 cells. Importantly, the stable pool generation protocol is also applicable to HEK293S GnTI- (N-acetylglucosaminyltransferase I-negative) and Expi293F GnTI- suspension cells, facilitating production of high yields of proteins with less complex glycans for use in structural biology projects. Compared to HEK293S GnTI- stable pools, Expi293F GnTI- stable pools consistently produce proteins with similar or higher expression levels. HEK293-derived stable pools can lead to a significant cost reduction and greatly promote the production of high-quality proteins for diverse research projects.
Advanced selective dry etching of GaAs/AlGaAs in high density inductively coupled plasmas (2000)

We report a breakthrough for selective etching of GaAs over AlxGa1−xAs, x=0.2, layer with a high density plasma source. This result is particularly important for III–V devices such as heterojunction bipolar transistors (HBTs) or high electron mobility transistors (HEMTs). For example, fabrication of HBTs requires a process for selective etching of a GaAs contact layer while stopping on AlGaAs layer. Inductively coupled plasma (ICP) etching with BCl3/SF6/N2/He chemistries showed extremely high selectivity of GaAs over AlGaAs (&amp;gt;200:1) and a photoresist (&amp;gt;10:1). This process also produced excellent sidewall passivation on GaAs with reasonably high rate (&amp;gt;1500 Å /min.). Both scanning electron microscope and atomic force microscope data showed AlGaAs etch stop layer was quite smooth after processing. We found that He played a key role in enhancing selectivity and obtaining smooth AlGaAs surfaces. When used with resist masks, addition of N2 into BCl3/SF6 plasma helped formation of passivation on the sidewall and maintained high anisotropy. An optimized condition with BCl3/SF6/N2/He ICP plasmas showed excellent pattern transfer into GaAs with high rate, anisotropy, and selectivity.
Comparison of Chlamydia antigen and AD-like pathology in the brains of BALB/c mice following intranasal infection with Chlamydia muridarum or Chlamydia pneumoniae (2013)

Previous research indicates BALB/c mice inoculated with Chlamydia pneumoniae (Cpn) demonstrated AD-like pathology which suggests that this mouse model is valid for studying the pathogenesis implicated in Alzheimer’s disease (AD). Studies have demonstrated that Chlamydia trachomatis (Ctr) can disseminate from its primary site of infection and plays a major role in the induction of reactive arthritis. The objectives of this lab are: (1) to identify and localize Chlamydia antigens in the brains of BALB/c mice infected with C. muridarum and (2) to determine if infection with C. muridarum induces AD-like pathology comparable to Cpn. Using mouse adapted respiratory isolates of C. muridarum, we investigated whether C. muridarum disseminated from the respiratory tract to the brain. Mice were intranasally infected with plaqued C small Weiss (CSW) or plaqued mouse pneumonitis Weiss (MoPn Weiss). Brain tissue was isolated at 2 months post-infection. Serial sections from brains infected mice were analyzed for amyloid or Chlamydia antigens. Preliminary analysis of brain tissue demonstrated no detectable difference in C. muridarum antigen between mice receiving 1 x105 IFU and mice receiving 1 x101 IFU, whereas a small but detectable difference was identified in amyloid-specific labeling between these two experimental groups. In contrast, prominent Chlamydia-specific labeling was identified in the brains of Cpn-infected mice as well as substantial amyloid deposition at 2 months p.i.. These data suggest that, relative to Cpn AR-39 infection, C. muridarum infection is a weaker stimulus for inflammation, resulting in decreased amyloid deposition in the brains of BALB/c mice.
Model reference robust control for MIMO systems (1997)

Model reference robust control (MRRC) of single-input single-output (SISO) systems was introduced as a new means of designing I/O robust control (Qu et al. 1994). This I/O design is an extension of the recursive backstepping design in the sense that a nonlinear dynamic control (not static) is generated recursively. Backstepping entails the design of fictitious controls starting with the output stale-space equation and backstepping until one arrives at the input state-space equation where the actual control can be designed. At each step the system is transformed and a fictitious control is designed to stabilize the transformed state (Naik and Kumar 1992). It is shown in this paper that MRRC of multiple input multiple output (MIMO) systems is an extension of model reference control (MRC) of MIMO systems and MRRC of SISO systems. Unwanted coupling exists in many physical MIMO systems. It is shown that MRRC decouples MIMO systems using only input and output measurements rather than state feedback. This is a very desirable property, because in many instances state information is not available. A diagonal transfer function matrix is strictly positive real (SPR) if and only if each element on the diagonal is SPR. The fact that complicates the development of robust control laws is that the recursive backstepping procedure used in non-SPR SISO systems cannot be directly applied to diagonal MIMO non-SPR systems without the introduction of the augmented matrix or a pre-compensator. MRC of systems where one has perfect plant knowledge is reviewed. Assumptions are listed for the application of model reference robust control for MIMO systems. Model selection is presented as the right Hermite normal form of the plant transfer function matrix. MRRC is derived for MIMO systems that have a right Hermite normal form which is SPR and diagonal, and then for systems whose right Hermite normal form is diagonal but not SPR. Robust control laws are generated for achieving stability using Lyapunov's second method. Future research will focus on MIMO systems which are not diagonal.
van't-Hoff-Le-Bel-Fremdling: Bildung eines Phosphoniumkations mit einem planar-tetrakoordinierten Phosphoratom (1999)

Ein neuartiger faszinierender Koordinationsmodus wurde in der Phosphorchemie erzielt, der für das Verständnis der chemischen Bindung von fundamentalem Interesse ist. Neben der Synthese des ersten planaren Phosphoniumkations PR4+ 1 durch eine überraschend einfache Metathesereaktion wird eine verallgemeinerbare experimentelle Methode vorgestellt, um die scheinbar unerreichbare, energiereiche Region von planaren isoelektronischen und molekularen ER4-Systemen (E=B−, C, N+, Al−, Si, P+) zu erreichen.
Designing Zonal Organization into Tissue-Engineered Cartilage (2007)

Cartilage tissue engineering strategies generally result in homogeneous tissue structures with little resemblance to the native zonal organization of articular cartilage. The objective of this study was to use bilayered photopolymerized hydrogels to organize zone-specific chondrocytes in a stratified framework and study the effects of this three-dimensional coculture system on the properties of the engineered tissue. Superficial and deep zone chondrocytes from bovine articular cartilage were photoencapsulated in separate hydrogels as well as in adjacent layers of a bilayered hydrogel. Histology, mechanical testing, and biochemical analysis was performed after culturing in vitro. To evaluate the influence of coculture on tissue properties, the layers were separated and compared to constructs containing only superficial or deep cells. In the bilayered constructs, deep cells produced more collagen and proteoglycan than superficial cells, resulting in cartilage tissue with stratified, heterogeneous properties. Deep cells cocultured with superficial cells in the bilayered system demonstrated reduced proliferation and increased matrix synthesis compared to deep cells cultured alone. The bilayered constructs demonstrated greater shear and compressive strength than homogenous cell constructs. This study demonstrated that interactions between zone-specific chondrocytes affect the biological and mechanical properties of engineered cartilage. Strategies aimed to structurally organize zone-specific cells and encourage heterotypic cell interactions may contribute to improved functional properties of engineered cartilage.
Relaying and Radio Resource Partitioning for Machine-Type Communications in Cellular Networks (2016)

To accommodate massive access for machine-type communication (MTC) in cellular networks, we propose two single-hop relaying schemes exclusively designed for the MTC: signal-to-interference ratio-based relaying and location-based relaying. The relay nodes capture one or more MTC device (MTCD) transmissions and forward them to the base station (BS), thus reducing the signaling overhead in the cellular network. To efficiently use the spectrum, MTCDs make concurrent transmissions, and therefore create interference with each other. Unlike related work assuming known interference values for each link, we use stochastic geometry to characterize the received signal and interference powers. We derive the outage probability expressions and analytically calculate the maximum density of MTCDs that can be supported under an outage constraint. Moreover, the optimal partitioning of spectrum resources into the MTCD-to-relay, and relay-to-BS links, for maximum transmission capacity is presented.