gebhart/patrepeval huggingface dataset:
Investigations of the coordination chemistry of molybdenum with facultative tetradentate ligands possessing N2S2 donor sets. 3. Crystal and molecular structures of [MoO2(SCH2CH2NMe(CH2)nNMeCH2CH2S)], n = 2 or 3, and [MoO2(SC6H4NHCH2CH2NHC6H4S)] and a comparison to the structure of [MoO2(SCH2CH2NHCH2CH2SCH2CH2S)], a complex with the NS3 donor set (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigations of the coordination chemistry of molybdenum with facultative tetradentate ligands possessing N2S2 donor sets. 3. Crystal and molecular structures of [MoO2(SCH2CH2NMe(CH2)nNMeCH2CH2S)], n = 2 or 3, and [MoO2(SC6H4NHCH2CH2NHC6H4S)] and a comparison to the structure of [MoO2(SCH2CH2NHCH2CH2SCH2CH2S)], a complex with the NS3 donor setA. Bruce, J. L. Corbin, P. L. Dahlstrom, J. R. Hyde, M. Minelli, E. I. Stiefel, J. T. Spence, and Jon ZubietaCite this: Inorg. Chem. 1982, 21, 3, 917–926Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ic00133a013https://doi.org/10.1021/ic00133a013research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Effects of regulatory network organization and environment on PmrD connector activity and polymyxin resistance in Klebsiella pneumoniae and Escherichia coli (2020)

Abstract Polymyxins are a class of cyclic peptides with antimicrobial activity against Gram-negative bacteria. Resistance to these compounds is often mediated by pathways that also confer resistance to host antimicrobial peptides. In Enterobacteriaceae , the PhoQ/PhoP and PmrB/PmrA two-component systems regulate many of the genes associated with these resistance mechanisms. In K. pneumoniae , spontaneous polymyxin resistance is frequently acquired through inactivation of the gene mgrB , which encodes a negative regulator of PhoQ. However, this resistance mechanism has not been reported in other genera of Enterobacteriaceae , despite the presence of mgrB among many members of this family. In addition, the frequency of developing spontaneous resistance to the antimicrobial peptide polymyxin through chromosomal mutations is much higher in Klebsiella compared to Salmonella or E. coli . Here we show that in K. pneumoniae , PmrD is not required for polymyxin resistance arising from inactivation of mgrB . In addition, we show that in E. coli , the protein PmrD can activate PmrA under certain conditions. Our results suggest that the importance of PmrD connector activity in polymyxin resistance depends on both the network organization and on the environmental conditions associated with PmrB stimulation.
Discovering spatial relationships in geographic information databases for geodatasets integration (2003)

Describes a framework for developing the integration of multiple single theme datasets (maps). The novelty of this approach is that it is based on spatial data mining, in particular on spatial association rules. A spatial association rule is a rule indicating certain association relationships among of a set of spatial and possibly some non-spatial predicates. Prior to the generation of the association rules, the source maps are represented in a common vector structure. Spatial hierarchies are defined to determine the characteristics of the features belonging to distinct classes. A distance restriction to limit the search space is specified as a part of the user query. Structure, levels of abstraction and reduction of the space guarantee the use of only the necessary data to answer the user query. A characterization of the uncertainty in the fused map is given as the measure of correction of the framework.
The History, Mechanism, and Clinical Application of Auricular Therapy in Traditional Chinese Medicine (2015)

Auricular therapy includes acupuncture, electroacupuncture, acupressure, lasering, cauterization, moxibustion, and bloodletting in the auricle. For 2500 years, people have employed auricular therapy for treating diseases, but the methods have been limited to bloodletting and cauterization. Only after 1957, the international scientific community became aware that the map of the ear resembles an inverted fetus, its introduction has led to auricular acupuncture (AA) becoming a more systemic approach, and, following the identification and standardization of more precise points, AA has been employed in clinical applications. The mechanisms of AA are considered to have a close relationship with the autonomic nervous system, the neuroendocrine system, neuroimmunological factors, neuroinflammation, and neural reflex, as well as antioxidation. Auricular therapy has been applied, for example, for pain relief, for the treatment of epilepsy, anxiety, and obesity, and for improving sleep quality. However, the mechanisms and evidence for auricular therapy warrant further study.
Collectin-43 is a serum lectin with a distinct pattern of carbohydrate recognition. (1995)

Collectin-43 (CL-43) is a C-type serum lectin and a member of the collectin family of soluble proteins that are effector molecules in innate immunity. We have investigated the binding specificity of CL-43 using as model systems a panel of structurally defined oligosaccharides in the form of neoglycolipids, and several glycoproteins derived from the complement glycoprotein C3 during activation of the complement cascade. A specificity is revealed towards fucose as part of the Lea oligosaccharide sequence, and towards mannose as found on high mannose-type chains. These are features shared with other serum collectins, conglutinin and mannan-binding proteins; a major difference is the lack of detectable binding by CL-43 to N-glycosidic oligosaccharides terminating in N-acetylglucosamine. CL-43 has a unique pattern of reactivity towards high mannose-type oligosaccharides on the two glycosylation sites of C3 and derived glycoproteins: it binds to C3c (not bound by conglutinin and mannan-binding protein) but not to hydrolysed C3 [C3(H2O)], C3b or iC3b immobilized on microwells (all bound by conglutinin but not by mannan-binding protein). When these glycoproteins are sodium dodecyl sulphate (SDS)-treated and immobilized on nitrocellulose, CL-43 (but not conglutinin nor mannan-binding protein) binds strongly to C3(H2O), iC3b and C3c. The salient conclusions are, first, that there are remarkable positive or negative effects of carrier protein on oligosaccharide presentation and these differ for the individual collectins. Second, the different though partially overlapping binding patterns among the collectins may be important for their function as circulating effector molecules with broad surveillance capabilities.
How costly is it to achieve the Millennium Development Goal of halving poverty between 1990 and 2015 (2006)

Growth, Poverty, Inequality, Millennium Development Goals, Foreign aid, Investment, Sub-Saharan Africa
Clinical and Functional Characterization of TNNT2 Mutations Identified in Patients With Dilated Cardiomyopathy (2009)

We conclude that the combination of clinical, pedigree, molecular genetic, and functional data strengthen the interpretation of TNNT2 mutations in DCM.
Flexible scheduling for Real-Time services in High-Speed Packet Access cellular networks (2009)

This paper presents the hybrid channel-aware and real-time scheduler (HY-CART) for UMTS high-speed packet access networks. The latter works for both downlink and uplink scheduling, with slightly different embodiments due to the different technology constraints. Its basic principle is to select users based on their channel conditions when the deadlines are far ahead: as the deadlines approach, they become progressively more important. Furthermore, resources for scheduled users are allocated sparingly, i.e. enough to serve packets whose deadline is actually near, so as to make room for a possibly larger number of simultaneous users, and keeping into account the user channel state. Simulative evaluation shows that HY-CART performs better than the previous work, allowing more users to be served with the same resources.
A Dynamically Reconfigurable ECG Analog Front-End With a 2.5× Data-Dependent Power Reduction (2021)

This paper presents a reconfigurable electrocardiogram (ECG) analog front-end (AFE) exploiting bio-signals' inherent low activity and quasi-periodicity to reduce power consumption. This is realized by an agile, on-the-fly dynamic noise-power trade-off performed over specific cardiac cycle regions guided by a least mean squares (LMS)-based adaptive predictor leading to ∼2.5× data-dependent power savings. Implemented in 65 nm CMOS, the AFE has tunable performance exhibiting an input-referred noise ranging from 2.38 - 3.64 μV<sub>rms</sub> while consuming 307 - 769 nW from a 0.8 V supply. A comprehensive system performance verification was performed using ECG records from standard databases to establish the feasibility of the proposed predictor-based approach for power savings without compromising the system's anomaly detection capability or ability to extract pristine ECG features.
Using Longitudinal Social Media Analysis to Understand the Effects of Early College Alcohol Use (2018)

While college completion is predictive of individual career happiness and economic achievement, many factors, such as excessive alcohol usage, jeopardize college success. In this paper, we propose a method for analyzing large-scale, longitudinal social media timelines to provide fine-grained visibility into how the behaviors and trajectories of alcohol-mentioning students differ from their peers. Using propensity score stratification to reduce bias from confounding factors, we analyze the Twitter data of 63k college students over 5 years to study the effect of early alcohol usage on topics linked to college success. We find multi-year effects, including lower mentions of study habits, increased mentions of potentially risky behaviors, and decreases in mentions of positive emotions. We conclude with a discussion of social media data's role in the study of the risky behaviors of college students and other individual behaviors with long-term effects.
Classification of Environmentally Occurring Chemicals Using Structural Fragments and PLS Discriminant Analysis (1997)

Chemicals were classified according to one of the four classes as described by Verhaar et al. (Chemosphere 1992, 25, 471−491) based on the structural information present in fragments of these chemicals. A PLS discriminant analysis method with the classes as the response variables and the screens as the predictor variables was used. The data were modeled in two different ways. The response variables were either modeled individually (PLS1), resulting in one model for each class, or together in a unified PLS2 model. This method resulted in some good models and a few moderate ones. The inert and less inert chemicals are concentrated in a relatively small region, whereas the reactive and specifically acting chemicals were more spread out. The reactive chemicals showed some diffuse border with the inert chemicals. Distinction between reactive and specifically acting chemicals is not straightforward. Prediction of class membership for a set of high production volume chemicals (HPVCs), not formerly classified, was reasonably good. The results of the study are promising. The easily generated characterization of the compounds, by means of presence or absence of specific fragments, contained useful information for clustering and classification. The most obvious advantage of the strategy is the speed. The characterization of several thousands of compounds can be made in less than 1 h.
The DosR Regulon Modulates Adaptive Immunity and is Essential for Mycobacterium tuberculosis Persistence (2015)

Delayed adaptive responses, a hallmark of M. tuberculosis infection, not only lead to persistence but also interfere with the development of effective antituberculosis vaccines. The DosR regulon therefore modulates both the magnitude and the timing of adaptive immune responses in response to hypoxia in vivo, resulting in persistent infection. Hence, DosR regulates key aspects of the M. tuberculosis life cycle and limits lung pathology.
Runtime Adaptation Framework for Fulfilling Availability and Continuity Requirements of Network Services (2022)

&lt;p&gt;There is no data collection.&lt;/p&gt;
Circular beam, high power operation of 0.98 µmInGaAs/InGaAsP lasers with a tapered waveguide spot-size expander (1996)

A 0.98 µm InGaAs/InGaAsP strained quantum well laser with a laterally tapered waveguide spot-size expander is demonstrated to achieve highly reliable and stable lateral mode operation. This laser, which has a 0.8 µm wide ridge-neck at the facet, showed a linear L-I curve up to 340 mW, with circular and narrow beam divergence of 10° × 15°.
Resource Speed Optimization for Two-Stage Flow-Shop Scheduling (2015)

Multiple resource co-scheduling algorithms and pipelined execution models are becoming increasingly popular, as they better capture the heterogeneous nature of modern architectures. The problem of scheduling tasks composed of multiple stages tied to different resources goes under the name of “flow-shop scheduling”. This problem, studied since the ’50s to optimize production plants, is known to be NP-hard in the general case. In this paper, we consider a specific instance of the flow-shop task model that captures the behavior of a two-resource (DMA-CPU) system. In this setting, we study the problem of selecting the optimal operating speed of either resource with the goal of minimizing power consumption while meeting schedulability constraints. We derive an algorithm that finds an exact solution to the problem in polynomial time, hence it is suitable for online operation even in the presence of variable real-time workload.
J0470101 Current status and future works of researches on self-healing materials (2014)

Recently self-healing materials are desired from the various applications. Since replying the desires, the self-healing researchers are required to organize the collaborating research group between universities, industry and national government. For the final goal, it is required to raise the name recognition of this area of research more. One of the examples is to conduct on information dissemination which utilized the IT environment.
Electronic transport properties of Bi/sub x/Te/sub y/-infiltrated synthetic opals (2002)

We have demonstrated that crystalline Bi/sub x/Te/sub y/ can be grown directly inside the 100-200 nm diameter pores of a synthetic opal host using a metal-organic chemical vapor deposition (MOCVD). A series of Bi/sub x/Te/sub y/-infiltrated opal samples have been characterized by X-ray powder diffraction, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDXS). Thermoelectric power values in the infiltrated opal samples ranged from -70 /spl mu/V/K to +200 /spl mu/V/K at room temperature T=300 K for the Bi- and the Te-rich Bi/sub 2/Te/sub 3/ compositions, respectively. The n-type (Bi-rich) samples were found to exhibit metallic electrical resistivity R (dR/dT>0) from 10 to 300 K, while the p-type (Te-rich) samples demonstrated negative dR/dT.
The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development (2018)

The molecular events driving specification of the kidney have been well characterized. However, how the initial kidney field size is established, patterned, and proportioned is not well characterized. Lhx1 is a transcription factor expressed in pronephric progenitors and is required for specification of the kidney, but few Lhx1 interacting proteins or downstream targets have been identified. By tandem-affinity purification, we isolated FRY like transcriptional coactivator (Fryl), one of two paralogous genes, fryl and furry (fry), have been described in vertebrates. Both proteins were found to interact with the Ldb1-Lhx1 complex, but our studies focused on Lhx1/Fry functional roles, as they are expressed in overlapping domains. We found that Xenopus embryos depleted of fry exhibit loss of pronephric mesoderm, phenocopying the Lhx1-depleted animals. In addition, we demonstrated a synergism between Fry and Lhx1, identified candidate microRNAs regulated by the pair, and confirmed these microRNA clusters influence specification of the kidney. Therefore, our data shows that a constitutively-active Ldb1-Lhx1 complex interacts with a broadly expressed microRNA repressor, Fry, to establish the kidney field.
Abstract 5442: The Collaborative Ocular Oncology Group study number 2: A prospective multi-center evaluation of uveal melanoma prognostic biomarkers (2020)

Abstract Introduction: Uveal melanoma (UM) is a highly aggressive eye cancer that leads to metastatic death in up to half of patients. UM has a propensity to undergo early micrometastasis prior to treatment of the primary tumor, with later emergence of overt metastatic disease. UM can be stratified into Class 1 (low metastatic risk) and Class 2 (high metastatic risk) using a prospectively validated 12-gene expression profile (GEP) molecular prognostication classifier. The Collaborative Ocular Oncology Group Study 2 (COOG2) is being conducted to prospectively evaluate new prognostic biomarkers in UM, including expression of PRAME, and prognostic driver mutations in BAP1, SF3B1, and EIF1AX. Methods: The COOG2 is a 24 center, prospective study of UM patients undergoing prognostic testing using the CLIA-certified DecisionDx-UM test (Castle Biosciences, Inc) between July 2017 and December 2019. Molecular analysis is performed on residual clinical samples. Data collected include clinical annotations, patient outcomes, GEP, PRAME status, and mutations in BAP1, SF3B1, and EIF1AX. Results: To date, there are 1300 participants enrolled. The baseline characteristics are as follows: 52% male, and 48% female; 87% non-Hispanic, 3% Hispanic, and 10% unknown. GEP classification is 66% class 1 and 34% class 2. PRAME status is 68% PRAME (-) and 32% PRAME (+). Targeted sequencing has been performed on 650 samples and is being analyzed. Conclusions: The COOG2 will establish a new standard of prognostic testing accuracy from a single fine needle biopsy in UM. The resulting integrated prognostic testing platform will be used as a stratification tool for entry into clinical trials of adjuvant therapy in high-risk patients. Citation Format: Christina L. Decatur, Michael A. Durante, Zelia M. Correa, Thomas M. Aaberg, Prithvi Mruthyunjaya, Amy C. Schefler, J. William Harbour. The Collaborative Ocular Oncology Group study number 2: A prospective multi-center evaluation of uveal melanoma prognostic biomarkers [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5442.
GPR65 as a potential immune checkpoint regulates the immune microenvironment according to pan-cancer analysis (2023)

It has been reported that inhibition of GPR65 may be effective for the treatment of certain cancers. Nevertheless, the role of GPR65 in various cancers remains unknown. We conducted an exhaustive pan-cancer analysis of GPR65 using multiple databases, including TCGA, GTEx, BioGPS, HPA, cBioPortal, and GeneCards. GPR65 was found to be differentially expressed in various cancers and linked to tumor mutational burden (TMB), microsatellite instability (MSI), and Ploidy, playing a key function in the tumor microenvironment (TME). It is closely linked to the development of Th17 cells as well as Th1 and Th2 cells in certain cancers. Our findings indicate that the expression of GPR65 is highly linked with clinical prognosis, mutations, and immune cell infiltration. It was revealed as an indicator of patient prognosis as well as a possible immunomodulatory role. As a possible new immunological checkpoint, GPR65 could be a target for tumor immunotherapy.
Correction to Surface Reconstruction-Induced Coincidence Lattice Formation Between Two-Dimensionally Bonded Materials and a Three-Dimensionally Bonded Substrate (2014)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Surface Reconstruction-Induced Coincidence Lattice Formation Between Two-Dimensionally Bonded Materials and a Three-Dimensionally Bonded SubstrateJos E. Boschker*, Jamo Momand, Valeria Bragaglia, Ruining Wang, Karthick Perumal, Alessandro Giussani, Bart J. Kooi, Henning Riechert, and Raffaella CalarcoCite this: Nano Lett. 2014, 14, 8, 4924Publication Date (Web):July 22, 2014Publication History Published online22 July 2014Published inissue 13 August 2014https://pubs.acs.org/doi/10.1021/nl502672qhttps://doi.org/10.1021/nl502672qcorrectionACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views439Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (105 KB) Get e-Alertsclose Get e-Alerts
Time hopping and frequency hopping in ultrawideband systems (2004)

This paper analyzes frequency-hopping (FH) and time-hopping (TH) as multiple access format for ultrawideband communications. We apply the concept of "fourthegy", recently introduced by Subramanian and Hajek, to both TH and FH. We find that the design rules are different for FCC-compliant systems (where the power spectral density is limited) than for conventional systems (where the energy per bit is limited). We find that fourthegy, and thus possible information rate, is maximized by using a bandwidth that is as large allowed by the FCC. For TH systems, a low duty cycle should be used. For FH, a subdivision into as many bands as possible should be used, and the dwell time on each frequency should be at least as long as the delay spread of the channel.