gebhart/patrepeval huggingface dataset:
Foamy virus replication: implications for interaction with other retroviruses and host cellular sequences. (2001)

Foamy viruses (FV) comprise one of the seven genera of retroviruses. These viruses infect most non-human primates as well as cats, cows and horses. Infections are persistent and life-long, but have no pathogenic consequences. Viral replication in vivo is at a very low level, but virus can be recovered years after infection. Humans can acquire FV as zoonotic infections which are also life-long. Although FV are highly cytopathic to fibroblast cultures, some cell lines can be infected with FV without any syncytium formation or cell death. Thus, material obtained from infected animals could contain FV proviruses without any obvious cytopathicity. The consequences of FV in biological material is not known. Little is known about how FV package their genomes, or whether they are able to package cellular genes which could have consequences for recipient cells. In addition, possible recombination between FV and other retroviruses has not been studied. Future studies of this virus should focus on the packaging ability of FV and whether they can recombine with other retroviruses.
Infrared Spectroscopy of Human Cells and Tissue. Part VII: FT-IR Microspectroscopy of DNase- and RNase-Treated Normal, Cirrhotic, and Neoplastic Liver Tissue (2000)

In our efforts to understand the infrared spectral features of cells and tissues, and the spectral changes occurring between normal and disease states, we reported previously a detailed correlation between histochemical/immunohistochemical and spectral results. These results suggested an increase of nucleic acid spectral contributions in neoplastic, as compared to normal, tissue samples. In the present paper, these studies are extended to report the spectral features of DNA and RNA separately in these tissue samples. This was accomplished by selectively digesting either DNA or RNA from tissue sections, leaving behind the protein matrix with nuclear/cytoplasmic RNA or the protein matrix with nuclear DNA, respectively. These results demonstrate that the spectral changes between normal and neoplastic tissue are mostly due to an enhanced signature of DNA in neoplastic tissue. This enhancement is sufficiently large to suggest that it is most likely due to an increased detectability of DNA, rather than an increase in concentration.
Autofluorescence Microscopy for Real-Time Imaging of Human Esophageal Disease (2009)

Autofluorescence microscopy is explored for real-time imaging of human esophagus tissue and detection of disease associated modifications. This approach was also tested using a prototype endoscopy probe.
Value of Personalized Medicine—Reply (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Particle Size on Antioxidant Activity and Cytotoxicity in Purple Corn Seed Powder (2012)

본 연구에서는 검정찰옥수수 종실을 일반분쇄와 저온미세분쇄를 하여 입자크기에 따른 항산화 활성과 cytotoxicity를 평가하여 이용성 증진을 하고자 연구를 수행하였다. 본 연구의 결과를 요약하면 다음과 같다. 1. 분쇄 정도에 따른 평균값은 일반분쇄가 <TEX>$473.7{\mu}m$</TEX>, 저온미세분쇄 <TEX>$17.2{\mu}m$</TEX>이었으며 중간값은 <TEX>$336.9{\mu}m$</TEX>와 <TEX>$13.4{\mu}m$</TEX>를 나타내었다. 2. TEAC 활성 측정 결과 일반분쇄는 <TEX>$3.87{\mu}mol$</TEX> TE/g로서 저온미세분쇄 <TEX>$5.15{\mu}mol$</TEX> TE/g보다 낮은 활성을 보였다. FRAP 활성 측정에서는 저온미세분쇄가 <TEX>$10.08{\mu}mol$</TEX> Fe(II)/g로 일반분쇄 <TEX>$8.86{\mu}mol$</TEX> Fe(II)/g보다 높은 활성을 보였다 3. 간암 세포주(Hep-G2) 성장억제에 미치는 영향은 1 mg/ml 농도에서 검정찰옥수수 종실을 일반분쇄(31.48%)한 것보다 저온미세분쇄(27.41%)를 한 경우가 암세포 생장 억제 효과를 큰 것으로 나타났다. 4. 대장암 세포주인 HCT-116에서는 1 mg/ml에서 분쇄정도에 따라 큰 차이를 보이지 않았으며, 유방암 세포주(MCF-7)에서는 일반분쇄가 미세분쇄보다 높은 생장억제를 보였다. This study was carried out to evaluate antioxidant and anticancer activity of crudes extracts from colored corn (Zea mays. L.) among particle size with different pulverizing methods (pin mill and ultra fine pulverizer). In cytotoxicity test using extracts from the flours grounded by pin mill and ultra fine pulverizer respectively, it showed that A-549 was the highest anticancer activity among in vitro using 4 cancer cell line types (Hep-G2, A-549, HCT-116 and MCF-7). Assessing the antioxidant activities of crude extracted from different pulverizing methods was measured by trolox equivalent antioxidant capacity (TEAC) and ferric reducing antioxidant power (FRAP). Higher scanvening activity against free radical was observed in the crude extracted from small particle size flours of colored corn than in those of the big particle size.
Pre-RAKE and multiuser detection techniques in UTRA-TDD systems (2002)

This paper is concerned with the application of pre-RAKE processing in the up link of a DS-CDMA system for a wireless Local Loop (WLL) scenario with time division duplex (TDD) access. It is well known that RAKE processing allows optimum time diversity gain in a multipath channel. An alternative approach, known as pre-RAKE processing, exploits the channel reciprocity in TDD systems in the up and down links to perform the optimum combination at the transmitter with the consequent receiver simplification. Typically, the pre-RAKE works at the base station, transmitting all users information with their particular pre-distortion. In this paper we explore another possibility, that is, each user performs its own pre-distortion, in order to simplify the synchronization and multiuser detection at the base station. Several simulations show its feasibility in comparison with standard multiuser detection techniques.
Addressing Religious and Cultural Differences in Views on Transplantation, Including Composite Tissue Allotransplantation (2011)

Composite tissue allotransplantation is a rapidly developing field in plastic and reconstructive surgery and therefore imposes an obligation upon plastic and transplant surgeons to familiarize themselves with some unique aspects of this new discipline. The visible nature of extremities, and the face, presents a special hurdle when seeking the consent of the donor's family, as well as the recipient. Religious and sociocultural backgrounds of both the donor and recipient may have an important impact on the outcome of the donation and acceptance process. The purpose of this review is to present the current positions of major religious groups on allotransplantation and the cultural responses to the religious stances. In this context, we have investigated whether there are any specific religious or cultural restrictions against the practice of composite tissue allotransplantation.
A case with right hip pain (2015)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
CoQ 10 selective miscibility and penetration into lipid monolayers with lower lateral packing density (2017)

CoQ<sub>10</sub> is ubiquitously present in eukaryotic cells. It acts as electron carrier in the electron transport chain of the inner membrane of the mitochondria to facilitate aerobic cellular respiration. A highly stable lipid nanodispersion formulation containing CoQ<sub>10</sub> (BPM31510) is currently in clinical investigation for treatment of cancer. This study was designed to determine whether biophysical interactions between CoQ<sub>10</sub> and lipid, in part, explain the observed stability and cellular accumulation of CoQ<sub>10</sub> in cells and tissues. A lipid monolayer at the air-water interface was used as an experimental membrane model to measure CoQ<sub>10</sub> penetration and solubility. Lipid monolayers with varying proportions of CoQ<sub>10</sub> were laterally compressed to measure CoQ<sub>10</sub> miscibility and lateral organization. Additionally, lipid monolayers with varying lateral packing densities were spread at the air-water interface and CoQ<sub>10</sub> was injected in proximity to measure its rate of penetration. Our results demonstrate that CoQ<sub>10</sub> selectively penetrates into lipid monolayers with a lower lateral packing density, and is excluded by monolayers of higher packing densities. Data also indicates that CoQ<sub>10</sub>-lipid mixing is non-ideal. CoQ<sub>10</sub> presence in lipid monolayers is biphasic, with one phase occupying the interstitial space between the DMPC lipids, and the other phase is present as pure CoQ<sub>10</sub> domains. This work provides further insight into mechanism of action of CoQ<sub>10</sub> based formulations that can significantly increase intracellular CoQ<sub>10</sub> concentration to show pleotropic effects on cellular functions.
Hyperemic stress myocardial perfusion cardiovascular magnetic resonance in mice at 3 Tesla: initial experience and validation against microspheres (2013)

First-pass myocardial stress perfusion CMR in a mouse model is feasible at 3 Tesla. Rest and stress MBF values were consistent with existing literature and perfusion reserve correlated closely to microsphere analysis. Data were acquired on a 3 Tesla scanner using an approach similar to clinical acquisition protocols, potentially facilitating translation of imaging findings between rodent and human studies.
Picosecond optoelectronic measurement of S parameters and optical response of an AlGaAs/GaAs HBT (1990)

The S parameters of an AlGaAs/GaAs heterojunction bipolar transistor (HBT) are measured using a picosecond optoelectronic system. The measured S parameters show qualitatively good agreement with those obtained using a conventional vector network analyzer. The optical response of the HBT is also measured using this system by directly illuminating the base-collector region. Used as a phototransistors, the HBT shows pulse widths with full-width half-maximum (FWHM) as short at 15 ps.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Enhanced Plasmonic Behavior of Incomplete Nanoshells: Effect of Local Field Irregularities on the Far-Field Optical Response (2011)

Plasmonic behavior of core–shell-type nanostructures is currently the focus of intense research, particularly because of the tunable optical response of such materials suitable for emerging applications such as laser-induced interstitial thermotherapy, surface-enhanced Raman scattering, and biosensing. In this work, we report on the plasmonic behavior of incomplete nanoshells, providing insight into their evolution and growth. During the initial stages of formation, well-separated, noninteracting metallic nanoparticles at the surface of a dielectric core behave like isolated particles, but irregular and intense local electric fields (hot spots) are created when the number of metallic spheres increases, dramatically affecting the far-field optical response of the integral structure. Under the action of these local fields, the position of the surface plasmon resonance (SPR) suffers a dramatic red shift up to 50% higher than that of a complete nanoshell. The presented results open up the possibility of fabricating metallic nanoshells that are more efficient than the conventional ones for biological applications.
Effect of a dietary antioxidant package on immune function and antioxidant status of IBD cats. (2007)

The objective of this study is to evaluate the effect of antioxidants on immune and inflammatory parameters in cats with inflammatory bowel disease (IBD). In this study, 10 healthy and 10 IBD cats were fed wet food with low antioxidants (CTRL) and test food (AOX) with added vitamin E, vitamin C and beta carotene (85.2 vs 235.6 IU, 35.4 vs 87.3 μg/g, 0.05 vs 0.92 μg/g respectively) for 4 weeks each in a randomized cross-over design. Both foods were completely balanced for adult cats. Serum vitamin E and C, DNA damage (comet assay), lymphocyte subsets and proliferation were measured at weeks 4 and 8. Real time PCR was used to determine cytokine levels from stimulated lymphocytes ex vivo. The results showed that serum vitamin E and C were significantly increased in healthy (972.9 vs 775.4 μmol/L, 215.8 vs 164.7 μmol/L) and IBD cats (833.6 vs 636.2, 232.8 vs 159.0 μmol/L) on the AOX vs CTRL food (p<0.05). IBD cats had significantly higher lymphocyte proliferative activity when stimulated with ConA (1.63 vs 1.24, p<0.05) and PWM (1.21 vs 1.06, p=0.054) and higher CD4+ T helper cells compared to the healthy cats (p<0.05). In contrast, stimulated lymphocytes from IBD cats produced significantly lower levels of IL1ß and IL2 than those from healthy cats (p<0.05). The AOX food tended to reduce the lymphocyte proliferation activity in both groups of cats. The results showed that IBD cats have a dysregulated and hyper-inflammatory immune response compared to healthy cats. Higher levels of antioxidants or nutrients such as fish oil may be indicated for decreasing inflammation.
Liquid-phase chromatography detector (2024)

A liquid-phase chromatography detector comprising a flow cell having an inlet tubular conduit for receiving a liquid chromatographic effluent and discharging it as a flowing columnar stream onto a vertically adjustable receiving surface spaced apart from and located vertically below and in close proximity to the discharge end of the tubular conduit; a receiver adapted to receive liquid overflowing from the receiving surface; an exit conduit for continuously removing liquid from the receiver; a light source for focussing fluorescence-producing light pulses on the flowing columnar stream as it passes from the outlet of the conduit to the receiving surface and a fluorescence detector to detect the produced fluorescence; a source of light pulse for producing acoustic waves in the columnar stream as it passes from the conduit outlet to the receiving surface; and a piezoelectric transducer adapted to detect those waves; and a source of bias voltage applied to the inlet tubular conduit and adapted to produce ionization of the liquid flowing through the flow cell so as to produce photocurrents therein and an electrical system to detect and record the photocurrents. This system is useful in separating and detecting individual chemical compounds from mixtures thereof.
A multinuclear NMR study of the affinity maturation of anti-NP mouse monoclonal antibodies: Comparison of antibody combining sites of primary response antibody N1G9 and secondary response antibody 3B62 (1993)

On the basis of multinuclear NMR data, the structures of the antibody combining sites of anti-4-hydroxy-3-nitrophenylacetyl (NP) antibodies were compared for N1G9, which is one of the primary response antibodies with low affinity for NP, and 3B62, which is one of the secondary response antibodies with high affinity for NP. It has been concluded, on the basis of the results of antibody engineering, that in most secondary response antibodies a Trp-->Leu exchange at position 33 of the heavy chain is primarily responsible for the increased affinity for NP [Allen, D., Simon, T., Sablitzky, F., Rajewsky, K., & Cumano, A. (1988) EMBO J. 7, 1995-2001]. Although 3B62 exhibits one of the highest affinities for NP, it lacks the Trp-->Leu exchange at position 33 of the heavy chain. A variety of stable isotope-labeled Fab analogues of N1G9 and 3B62 have been prepared. Chain-specific resonance assignments were made by recombination of the heavy chains and light chains of the Fab fragments. Binding experiments of a spin-labeled hapten and NOESY experiments have demonstrated that, compared with the environment of the antibody combining site of N1G9, the combination of mutations (including one codon deletion) and the particular D-JH rearrangement in the heavy chain of 3B62 affords a more hydrophobic environment, which is formed by one Tyr residue originating from the light chain and two Tyr residues originating from the heavy chain.(ABSTRACT TRUNCATED AT 250 WORDS)
Protoporphyrinogen Oxidase-Inhibiting Herbicides (1991)

Several commercial and experimental herbicides such as p -nitrodiphenyl ethers, oxadiazoles, and cyclic imides inhibit protoporphyrinogen IX oxidase (Protox), the enzyme that converts protoporphyrinogen IX to protoporphyrin IX (Proto). This leads to uncontrolled autooxidation of the substrate and results in accumulation of Proto. Blockage of the porphyrin pathway at this site inhibits synthesis of both chlorophylls and heme. Heme is a feedback regulator of the porphyrin pathway. Thus, inhibition of Protox also deregulates the pathway, causing increased carbon flow to the accumulating pool of Proto. Proto is a potent photosensitizer that generates high levels of singlet oxygen in the presence of molecular oxygen and light. In plants treated with these herbicides, damage is light dependent and closely correlated with the level of Proto that accumulates. Proto accumulation is apparently largely extraplastidic, resulting in rapid photodynamic damage to the plasmalemma and tonoplast. After high levels of Proto accumulate in response to these herbicides, protochlorophyllide (PChlide) levels can increase also; however, Proto appears to be the primary photodynamic pigment responsible for the herbicidal activity.
Weight Selection for Pattern Control of Paraboloidal Reflector Antennas with Reconfigurable Rim Scattering (2023)

It has been recently demonstrated that modifying the rim scattering of a paraboloidal reflector antenna through the use of reconfigurable elements along the rim facilitates sidelobe modification including cancelling sidelobes. In this work we investigate techniques for determining the unit-magnitude weights (i.e., weights which modify the phase of the scattered signals) to accomplish sidelobe cancellation at arbitrary angles from the reflector axis. Specifically, it is shown that despite the large search space and the non-convexity of the cost function, weights can be found with reasonable complexity which provide significant cancellation capability. First, the optimal weights without any magnitude constraints are found. Afterwards, algorithms are developed for determining the unit-modulus weights with both quantized and unquantized phases. Further, it is shown that weights can be obtained that both cancel sidelobes while providing a constant main lobe gain. A primary finding is that sufficiently deep nulls are possible with essentially no change in the main lobe with practical (binary or quaternary) phase-only weights.
Continuous infusion versus intermittent administration of ceftazidime in critically ill patients with suspected gram-negative infections (1996)

The pharmacodynamics and pharmacokinetics of ceftazidime administered by continuous infusion and intermittent bolus over a 4-day period were compared. We conducted a prospective, randomized, crossover study of 12 critically ill patients with suspected gram-negative infections. The patients were randomized to receive ceftazidime either as a 2-g intravenous (i.v.) loading dose followed by a 3-g continuous infusion (CI) over 24 h or as 2 g i.v. every 8 h (q8h), each for 2 days. After 2 days, the patients were crossed over and received the opposite regimen. Each regimen also included tobramycin (4 to 7 mg/kg of body weight, given i.v. q24h). Eighteen blood samples were drawn on study days 2 and 4 to evaluate the pharmacokinetics of ceftazidime and its pharmacodynamics against a clinical isolate of Pseudomonas aeruginosa (R288). The patient demographics (means +/- standard deviations) were as follows: age, 57 +/- 12 years; sex, nine males and three females; APACHE II score, 15 +/- 3; diagnosis, 9 of 12 patients with pneumonia. The mean pharmacokinetic parameters for ceftazidime given as an intermittent bolus (IB) (means +/- standard deviations) were as follows: maximum concentration of drug in serum, 124.4 +/- 52.6 micrograms/ml; minimum concentration in serum, 25.0 +/- 17.5 micrograms/ml; elimination constant, 0.268 +/- 0.205 h-1; half-life, 3.48 +/- 1.61 h; and volume of distribution, 18.9 +/- 9.0 liters. The steady-state ceftazidime concentration for CI was 29.7 +/- 17.4 micrograms/ml, which was not significantly different from the targeted concentrations. The range of mean steady-state ceftazidime concentrations for the 12 patients was 10.6 to 62.4 micrograms/ml. Tobramycin peak concentrations ranged between 7 and 20 micrograms/ml. As expected, the area under the curve for the 2-g q8h regimen was larger than that for CI (P = 0.003). For IB and CI, the times that the serum drug concentration was greater than the MIC were 92 and 100%, respectively, for each regimen against the P. aeruginosa clinical isolate. The 24-h bactericidal titers in serum, at which the tobramycin concentrations were < 1.0 microgram/ml in all patients, were the same for CI and IB (1:4). In the presence of tobramycin, the area under the bactericidal titer-time curve (AUBC) was significantly greater for IB than CI (P = 0.001). After tobramycin was removed from the serum, no significant difference existed between the AUBCs for CI and IB. We conclude that CI of ceftazidime utilizing one-half the IB daily dose was equivalent to the IB treatment as judged by pharmacodynamic analysis of critically ill patients with suspected gram-negative infections. No evaluation comparing the clinical efficacies of these two dosage regimens was performed.
<title>Data acquisition systems for the Sloan Digital Sky Survey</title> (1994)

The Sloan Digital Sky Survey will image (Pi) steradians about the north galactic cap in five filters, and acquire one million spectra using a dedicated 2.5 m telescope at the Apache Point Observatory in New Mexico. We describe the data acquisition system for the survey's three main detectors: an imaging camera, mounting 54 Tektronix charge-coupled devices (CCD); a pair of spectrographs, each mounting a pair of CCDs; and a smaller monitor telescope camera. We describe the system's hardware and software architecture, and relate it to the survey's special requirements for high reliability and need to understand its instrumentation in order to produce a consistent survey over a five year period.