gebhart/patrepeval huggingface dataset:
Identification of HLA-A3 and -B7-Restricted CTL Response to Hepatitis C Virus in Patients with Acute and Chronic Hepatitis C (1999)

The inverse relationship between peripheral blood CTL responsiveness to multiple hepatitis C virus (HCV) epitopes and viral titer in patients with persistent HCV infection suggests that enhancement of the CTL response might result in viral clearance. Since several HLA-A2-restricted HCV CTL epitopes are already known, we aimed to identify CTL epitopes restricted by other HLA types in an effort to expand the epitope repertoire available for T cell-mediated therapeutic vaccine development. Scanning of 14 different HCV genome sequences for the presence of conserved peptides containing the HLA-A3 and -B7 motifs revealed 9- to 10-mer peptides that were synthesized and assayed for binding to HLA-A3, -B7 supertype molecules. Peptides with good HLA-binding affinities and cross-reactivities with at least three of five most common molecules of each supertype were tested for the ability to stimulate a memory CTL response in the peripheral blood from selected HCV-infected patients and normal seronegative donors in vitro. We identified eight HLA-A3 supertype-restricted CTL epitopes and one HLA-B7 supertype-restricted CTL epitope that were recognized by infected patients but not by healthy seronegative donors. HLA class I serotyping of 158 chronically infected patients revealed that 80% expressed one or more of HLA molecules belong to either the A2, A3, or B7 supertypes. In conclusion, the epitopes, herein identified combined with previously defined HLA-A2-restricted CTL epitopes, should be useful for the design of an ethnically unbiased, therapeutic CTL vaccine for the treatment of patients with chronic HCV infection.
Characterization of Basal Plane Dislocations in 4H-SiC Substrates by Topography Analysis of Threading Edge Dislocations in Epilayers (2010)

Burgers vector directions of threading edge dislocations (TEDs) in 4H-SiC epitaxial layer are distinguished by grazing incidence high resolution topography. Based on comparison between appearance of KOH etch pits and direction of TED Burgers vector, the size difference of the TED etch pits is found to be dependent on their Burgers vector directions. Examining TEDs in the epilayer by topography, the Burgers vector direction of basal plane dislocations (BPDs) in the substrate is identified. Correspondence between the topography contrast and the sense of a BPD is also investigated.
Treg Cells As Potential Cellular Targets for Functionalized Nanoparticles in Cancer Therapy (2016)

Treg cell-mediated immune suppression appears to represent a significant barrier to effective anticancer immune responses and their inactivation or removal is viewed as a potential therapeutic approach. Although suitable tools for selective Treg cell manipulation in man are missing, their number and function can be altered by a number of drugs and biologicals and by reprogramming tumor-infiltrating antigen presenting cells. Nanoparticles offer exceptional new options in drug and gene delivery by prolonging the circulation time of their cargo, protecting it from degradation and promoting its local accumulation in cells and tissues. In tumor therapy, the use of nanoparticles is expected to overcome limitations in drug delivery and provide novel means for cell-specific functional alteration. In this perspective, we summarize strategies suitable for interference with Treg-mediated suppression, discuss the potential use of nanoparticles for this purpose and identify additional, unexplored opportunities.
Oral human papillomavirus infection in England and associated risk factors: a case–control study (2018)

ID14106.
AN ACCURATE AND EFFICIENT ALGORITHM FOR DETECTION OF RADIO BURSTS WITH AN UNKNOWN DISPERSION MEASURE, FOR SINGLE-DISH TELESCOPES AND INTERFEROMETERS (2017)

ABSTRACT Astronomical radio signals are subjected to phase dispersion while traveling through the interstellar medium. To optimally detect a short-duration signal within a frequency band, we have to precisely compensate for the unknown pulse dispersion, which is a computationally demanding task. We present the “fast dispersion measure transform” algorithm for optimal detection of such signals. Our algorithm has a low theoretical complexity of , where N f , N t , and N Δ are the numbers of frequency bins, time bins, and dispersion measure bins, respectively. Unlike previously suggested fast algorithms, our algorithm conserves the sensitivity of brute-force dedispersion. Our tests indicate that this algorithm, running on a standard desktop computer and implemented in a high-level programming language, is already faster than the state-of-the-art dedispersion codes running on graphical processing units (GPUs). We also present a variant of the algorithm that can be efficiently implemented on GPUs. The latter algorithm’s computation and data-transport requirements are similar to those of a two-dimensional fast Fourier transform, indicating that incoherent dedispersion can now be considered a nonissue while planning future surveys. We further present a fast algorithm for sensitive detection of pulses shorter than the dispersive smearing limits of incoherent dedispersion. In typical cases, this algorithm is orders of magnitude faster than enumerating dispersion measures and coherently dedispersing by convolution. We analyze the computational complexity of pulsed signal searches by radio interferometers. We conclude that, using our suggested algorithms, maximally sensitive blind searches for dispersed pulses are feasible using existing facilities. We provide an implementation of these algorithms in Python and MATLAB.
Therapie von Mammazysten mit 2α-Bromergokryptin* (1981)

23 Frauen mit 138 subklinischen Mammazysten wurden über etwa ein Vierteljahr mit 2α-Bromergokryptin behandelt. Die Kontrollgruppe bestand aus dreizehn Frauen mit 54 Mammazysten.
Implementing Ethernet in the industrial environment (2002)

It is pointed out that Ethernet or IEEE Std 802.3 CSMA/CD (carrier sense multiple access with collision detection) network technology has migrated from the research lab to the office to the factory floor. The factory floor challenges the integrity of this LAN (local area network) standard with high levels of noise, interference, and other environmental hazards. It is argued that, with careful planning, implementation, and documentation, Ethernet can succeed on the factory floor when using the right equipment for the application is used. In the present work, the different types of media for 802.3 network systems are compared to determine their applicability to the industrial environment. Emphasis is placed on the media characteristics, the equipment required, the topologies, and the installation considerations and costs for the available media types. Using the comparison results, different configurations of the network are examined to determine the advantages and disadvantages for each configuration, primarily noise susceptibility, reliability, and cost.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Präoperative Risikoanalyse (1999)

Jeder fünfte Patient, der ins Krankenhaus eingewiesen wird, ist alkoholkrank (12). Die Prävalenz alkoholkranker Patienten in operativen Kliniken ist dabei nicht geringer als in neurologisch/psychiatrischen Einrichtungen (12). Patienten mit einem Tumor des oberen Gastrointestinaltraktes oder nach einem Trauma sind sogar zur Hälfte alkoholkrank (3, 16, 19, 20, 27, 28). Diese Patienten sind als Hoch-Risiko-Patienten aufgrund ihrer Alkoholkrankheit anzusehen (16, 27).
The Proposal Preparation Program: A Group Mentoring, Faculty Development Model to Facilitate the Submission and Funding of NIH Grant Applications (2021)

This article describes the University of Minnesota Medical School Proposal Preparation Program (P3). P3 is designed to develop grant-writing skills for assistant professors preparing their first K- or R-series application to the National Institutes of Health (NIH). Three 4-month P3 cycles are conducted annually. For each cycle, a cohort of around 10 assistant professor participants and 5 regular faculty mentors meet for ten ~2-hour group sessions. Participants receive iterative oral and written feedback on their proposals in development within a small, interdisciplinary, group mentoring setting providing structure, accountability, guidance, and support. Between sessions, 1 peer and 1 mentor are assigned (on a rotating basis) to critique each participant's developing application. The sessions include a brief mentor-led presentation on a particular grant section followed by discussion of each participant's application conducted by the assigned reviewers. The cycle concludes with a mock NIH review session, in which each participant is matched with a University of Minnesota faculty content expert who critiques their completed application using NIH guidelines. In a survey sent to all past P3 participants as of 2018 (n = 194), 88% of respondents reported having submitted their P3-developed NIH grant, and 35% of these submitters reported funding success. A separate analysis of institutional data for all past P3 participants as of 2016 (n = 165) showed that 73% submitted at least 1 NIH proposal since completing P3 and that 43% of these had acquired NIH funding, for a combined total of $193 million in funding awarded. The estimated rate at which participants obtained funding for their P3-developed grant application (~35%) exceeds the national annual NIH grant funding rates (~20%) by approximately 50%. This article provides the practical information needed for other institutions to implement a P3-like program and presents a cost-benefit analysis showing the advantages of doing so.
The Dynamic Kinetic Resolution of Azlactones with Thiol Nucleophiles Catalyzed by Arylated, Deoxygenated Cinchona Alkaloids (2012)

A significant improvement of the available organocatalytic methods (in terms of product substrate scope and product enantiomeric excess) for the generation of enantioenriched α-amino acid thioesters via the dynamic kinetic resolution of azlactones is reported. C-9 arylated cinchona alkaloid catalysts have been found to be considerably superior to other bifunctional alkaloid catalysts as the promoters of this asymmetric process.
Surface plasmon polariton at the interface of dielectric and graphene medium using the Doppler broadening effect (2022)

Abstract We theoretically investigate the control of surface plasmon polariton (SPP) generated at the interface of dielectric and graphene due to effective variation of dielectric functions. The input light pulse is controlled and modified in a Doppler broadening dielectric medium. The controlled and modified output, from Doppler broadening dielectric medium is used to excite SPPs at the interface of graphene and dielectric medium. It is noted that at high Doppler width the absorption/dispersion and propagation length of SPPs become saturated and significantly affected by strength of the control fields. The inverse Doppler effect enhances the group speed of SPPs but suddenly decreases at the region of SPPs hole burning. These results have potential applications in optical tweezers, nano-photonics, radiations guiding, plasmonster technology, photovoltaic devices, data storage devices, biosensor technology and solar cells.
Calibration/Verification Plan (2005)

This Calibration/Verification Plan –Cal/Ver-Plan- sets the time schedule and is the master steering document for all calibration and verification activities in the TerraSAR-X Project during the Commissioning Phase. It is to be co-ordinated with the Flight Operations Plan from MOS [RD - 5].&#13;\nThis document defines the terms calibration, characterization, verification and validation for the TerraSAR-X project Comissioning Phase. It describes the complete document structure for the TerraSAR-X verification and the scheduling for all calibration and verification activities in the Comissioning Phase. &#13;\n&#13;\nThe calibration and in-flight instrument characterization is documented in detail in the TerraSAR-X In-Orbit Calibration Plan [RD - 4]. The IOCS Calibration Section receives its high level tasks and the high level schedule from this document.&#13;\n&#13;\n
Genome Sequence of Selenium-Solubilizing Bacterium Caulobacter vibrioides T5M6 (2016)

Caulobacter vibrioides T5M6 is a Gram-negative strain that strongly solubilizes selenium (Se) mineral into Se(IV) and was isolated from a selenium mining area in Enshi, southwest China. This strain produces the phytohormone IAA and promotes plant growth. Here we present the genome of this strain containing a large number of genes encoding resistances to copper and antibiotics.
Software Defined Radio for Underwater Applications using FPGA (2014)

This paper describes an Underwater Acoustic Communication system for establishing a two-way communication between monitoring station and the underwater device. In order to obtain high data rates with utilization of an effective bandwidth, Orthogonal Frequency Division Multiplexing Technique (OFDM) has been chosen. With the proposed OFDM parameters, we have done an offline analysis of the data and had even verified the results using an existing modem.
Approach to the Patient with Abdominal Pain (2008)

This chapter contains sections titled: Background and importance The neurobiology of pain Clinical assessment of the patient with abdominal pain Approach to the treatment of abdominal pain Conclusions References
A Novel and Direct Synthesis of Alkylated 2,2′‐Bithiophene Derivatives Using a Combination of Hypervalent Iodine(III) Reagent and BF3×Et2O. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Effects of interaction between the chelate rings and π‐conjugated systems in fused salphen complexes on UV‐Vis‐NIR spectra (2016)

Abstract Dinuclear (Zn 2 , Ni 2 , and NiZn) complexes of fused salphen with acene‐type annelation were synthesized from 3,7‐diformyl‐2,6‐dihydroxynaphthalene. The spectroscopic properties of these complexes were compared with those of their constitutional isomers with phene‐type annelation. The acene‐type complexes exhibited a characteristic absorption band in the near‐infrared region that showed a noticeable solvent effect. Time‐dependent density functional theory calculations suggested that the absorption arose from a π → π* transition localized at the naphthalene ring, which was perturbed by the adjoining chelate rings. Effects of the connection topology in the fused salphen complexes are discussed by comparison with those of polycyclic aromatic hydrocarbons.
An efficient denoising algorithm for global illumination (2017)

We propose a hybrid ray-tracing/rasterization strategy for realtime rendering enabled by a fast new denoising method. We factor global illumination into direct light at rasterized primary surfaces and two indirect lighting terms, each estimated with one path-traced sample per pixel. Our factorization enables efficient (biased) reconstruction by denoising light without blurring materials. We demonstrate denoising in under 10 ms per 1280×720 frame, compare results against the leading offline denoising methods, and include a supplement with source code, video, and data.
Twenty-Two Percent Efficient Pb-Free All-Perovskite Tandem Solar Cells Using SCAPS-1D (2022)

Herein, we reported the simulation study of lead (Pb)-free all-perovskite tandem solar cells using SCAPS-1D. Tandem solar cells are comprised of two different cells which are known as the top cell and the bottom cell. We simulated tandem solar cells using methyl ammonium germanium iodide (MAGeI<sub>3</sub>) as the top subcell absorber layer due to its wide band gap of 1.9 eV. Further, FA<sub>0.75</sub>MA<sub>0.25</sub>Sn<sub>0.25</sub>Ge<sub>0.5</sub>I<sub>3</sub> = FAMASnGeI<sub>3</sub> was used as the bottom subcell absorber layer due to its narrow band gap of 1.4 eV. The tandem solar cells were simulated with MAGeI<sub>3</sub> as the top cell and FAMASnGeI<sub>3</sub> as the bottom subcell using SCAPS-1D. Various electro-transport layers (ETLs) i.e., titanium dioxide, tin oxide, zinc oxide, tungsten trioxide, and zinc selenide, were used to examine the impact of ETL on the efficiency of tandem solar cells. The observations revealed that TiO<sub>2</sub> and ZnSe have more suitable band alignment and better charge-extraction/transfer properties. A reasonably improved efficiency of 23.18% and 22.4% have been achieved for TiO<sub>2</sub> and ZnSe layer-based tandem solar cells, respectively.
The genetic risk for COVID-19 severity is associated with defective innate immune responses (2020)

Abstract Recent genome-wide association studies (GWASs) of COVID-19 patients of European ancestry have identified genetic loci significantly associated with disease severity ( 1 ). Here, we employed the detailed clinical, immunological and multi-omics dataset of the Human Functional Genomics Projects (HFGP) to explore the physiological significance of the host genetic variants that influence susceptibility to severe COVID-19. A genomics investigation intersected with functional characterization of individuals with high genetic risk for severe COVID-19 susceptibility identified several major patterns: i. a large impact of genetically determined innate immune responses in COVID-19, with increased susceptibility for severe disease in individuals with defective monocyte-derived cytokine production; ii. genetic susceptibility related to ABO blood groups is probably mediated through the von Willebrand factor (VWF) and endothelial dysfunction. We further validated these identified associations at transcript and protein levels by using independent disease cohorts. These insights allow a physiological understanding of genetic susceptibility to severe COVID-19, and indicate pathways that could be targeted for prevention and therapy. One Sentence summary In this study, we explore the physiological significance of the genetic variants associated with COVID-19 severity using detailed clinical, immunological and multi-omics data from large cohorts. Our findings allow a physiological understanding of genetic susceptibility to severe COVID-19, and indicate pathways that could be targeted for prevention and therapy.
Image reconstruction using data-dependent triangulation (2001)

Image reconstruction based on data-dependent triangulation with new cost functions and optimization can create higher quality images than traditional bilinear or bicubic spline reconstruction. The article presents a novel method for image reconstruction using a piecewise linear intensity surface whose elements don't generally align with the coordinate axes. This method is based on the technique of data-dependent triangulation (DDT) that N. Dyn et al. (1990) introduced and has proven capable of producing more pleasing reconstructions than axis-aligned methods.
Acute Eosinophilic Pneumonia Leading to Acute Respiratory Failure in a Current Systemic Corticosteroid User (2013)

A 69-year-old female patient visited the emergency room with fever (38.3℃) and dyspnea. She had been taking prednisolone (5 mg once per day) and methotrexate (2.5 mg once per week) for rheumatoid arthritis for 2 years. Chest computed tomography (CT) showed bilateral, multifocal ground glass opacity with interlobular septal thickening. Peripheral blood leukocyte count was 6,520/mm(3) (neutrophils, 77.4%; eosinophils, 12.1%). During the night, mechanical ventilation was initiated due to the development of severe hypoxemia. Bronchoalveolar lavage fluid showed a high proportion of eosinophils (49%). Her symptoms improved dramatically after commencement of intravenous methylprednisolone therapy. This is the first report of idiopathic acute eosinophilic pneumonia developing in a current user of systemic corticosteroids.
Potential of Remote Sensing Devices (RSDs) to screen vehicle emissions (2019)

This report on the potential of Remote Sensing Devices (RSDs) to screen vehicle emissions summarizes the findings of a one-week measurement campaign performed in July 2017. \nTwo remote sensing devices from the companies HEAT and OPUS were installed on the roadside at the JRC Ispra site. Reference vehicles equipped with Portable Emission Measurement System (PEMS) were driven by the instruments serving as reference measurement systems to compare their results to the RSDs for different emissions. The focus during this exercise was on the gaseous pollutants NO, NO2 and CO from light duty vehicles. RSD and PEMS based measurements showed good agreement of the observed pollutants to CO2 ratios, the basic observable of RSDs, within the instruments range of observation. \nChallenged with a larger set of different vehicles, the RSD measurements provided an overview of expected observations for different vehicle types and emission standards. \nThe RSD performance has been put in relation to emissions that are expected from latest EURO 6 compliant vehicles on the road using instantaneous pollution to CO2 ratios from recent Real Driving Emissions (RDE) tests. Distinguishable probability distributions for NO-to-CO2 ratios for different emission standards and single vehicles were obtained. \nThese findings indicate that Remote Sensing Devices constitute a promising technology for the screening of vehicle emissions in order to identify high or low polluting vehicles and vehicle types under specific driving conditions.
Flow Kinetics of Molten Silicates through Thermal Barrier Coating: A Numerical Study (2019)

Infiltration of molten calcium–magnesium–alumina–silicates (CMAS) through thermal barrier coatings (TBCs) causes structural degradation of TBC layers. The infiltration kinetics can be altered by careful tailoring of the electron beam physical vapor deposition (EB-PVD) microstructure such as feather arm lengths and inter-columnar gaps, etc. Morphology of the feathery columns and their inherent porosities directly influences the infiltration kinetics of molten CMAS. To understand the influence of columnar morphology on the kinetics of the CAMS flow, a finite element based parametric model was developed for describing a variety of EB-PVD top coat microstructures. A detailed numerical study was performed considering fluid-solid interactions (FSI) between the CMAS and TBC top coat (TC). The CMAS flow characteristics through these microstructures were assessed quantitatively and qualitatively. Finally, correlations between the morphological parameters and CMAS flow kinetics were established. It was shown that the rate of longitudinal and lateral infiltration could be minimized by reducing the gap between columns and increasing the length of the feather arms. The results also show that the microstructures with long feather arms having a lower lateral inclination decrease the CMAS infiltration rate, therefore, reduce the CMAS infiltration depth. The analyses allow the identification of key morphological features that are important for mitigating the CMAS infiltration.
Effect of pre-operative internal obturator muscle mass index in MRI on biochemical recurrence of prostate cancer patients after radical prostatectomy: a multi-center study (2021)

Pre-operative IOM mass index was not associated with BCR; however, long-term follow-up is necessary to evaluate cancer-specific and overall survival of PCa patients.