gebhart/patrepeval huggingface dataset:
Advances in Laboratory Tests for Autoantibodies to Nuclear Antigens in Systemic Rheumatic Diseases (1984)

Journal Article Advances in Laboratory Tests for Autoantibodies to Nuclear Antigens in Systemic Rheumatic Diseases Get access Robert M. Nakamura, Robert M. Nakamura Search for other works by this author on: Oxford Academic PubMed Google Scholar Carol L. Peebles, Carol L. Peebles Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel P. Molden, Daniel P. Molden Search for other works by this author on: Oxford Academic PubMed Google Scholar Eng M. Tan Eng M. Tan Search for other works by this author on: Oxford Academic PubMed Google Scholar Laboratory Medicine, Volume 15, Issue 3, 1 March 1984, Pages 190–198, https://doi.org/10.1093/labmed/15.3.190 Published: 01 March 1984
The Neurological Basis for Cardiac Pain (2020)

This chapter discusses potential neural mechanisms that underlie the referral of anginal pain to somatic structures by using the spinothalamic system as the model. It addresses possible neurophysiological mechanisms that might explain why severe myocardial ischemia could occur without the experience of pain. Mechanosensitive and chemosensitive receptors located in heart transmit information via afferent fibers to the spinal cord. A common feature of cardiac pain sensation is its perceived location in somatic structures overlying or nearby the heart. Vagal afferent fibers do not appear to be involved with the eventual perception of cardiac pain, but evidence has accumulated to suggest that vagal afferent fibers have the capacity to modulate the cardiovascular and pain systems. Electrical and chemical stimulation of vagal afferent fibers can suppress responses to visceral stimuli in conscious animals. The neural mechanisms and pathways involved in the suppression of pinothalamic tract cell activity are unknown, but anatomical, electrophysiological and behavioral results suggests potential pathways for producing this suppression.
Electrochemical and Spectroscopic Studies on the Conformational Structure of Hemoglobin Assembled on Gold Nanoparticles (2011)

Protein conformational changes may be associated with particular properties such as function, transportation, assembly, tendency to aggregate, and potential cytotoxicity. Protein misfolding, in particular, has been intimately related to protein-mediated diseases. In this study, the conformational structure changes of hemoglobin (Hb) induced by the assembly on gold nanoparticles (AuNPs) surface were studied in detail by a combination of electrochemical method and various spectroscopic techniques including UV-vis absorption, fluorescence, circular dichroism (CD), and Fourier transform infrared (FTIR) spectroscopy. The results indicated that Hb in the Hb-AuNPs bioconjugate system that was prepared by the assembly of Hb on the surface of AuNPs underwent substantial conformational changes both at secondary and tertiary structure level. The assembly of Hb on the boundary surface of AuNPs could result a disturbance of the structure of Hb and induce the exposure of the heme group and tryptophan (Trp) residues to the solvent, leading to the enhancement in the electron transfer rate of the protein. The calculation from quantitative second-derivative infrared and CD spectra of the Hb-AuNPs bioconjugate system showed that AuNPs could induce the conversion of α-helix to β-sheet structures and unfolding of the protein. Moreover, the effects of the concentration and the size of AuNPs on the conformational structure changes of Hb in the bioconjugate system were also demonstrated. The results obtained here not only provide the detailed conformational behavior of Hb molecules on nanoparticles, but also create a framework for analyzing the biosafety of nanoparticles in terms of the biological behavior of biomacromolecules.
Dielectric constant and ac conductivity of the layered cobalt oxideBi2Sr2CoO6+δ: A possible metal-dielectric composite made by self-organization ofCo2+andCo3+ions (2007)

The dielectric constant and ac conductivity of a single-crystal sample of the layered cobalt oxide ${\mathrm{Bi}}_{2}{\mathrm{Sr}}_{2}\mathrm{Co}{\mathrm{O}}_{6+\ensuremath{\delta}}$ were measured along the $c$ axis from ${10}^{2}\phantom{\rule{0.3em}{0ex}}\text{to}\phantom{\rule{0.3em}{0ex}}{10}^{9}\phantom{\rule{0.3em}{0ex}}\mathrm{Hz}$ from $110\phantom{\rule{0.3em}{0ex}}\text{to}\phantom{\rule{0.3em}{0ex}}300\phantom{\rule{0.3em}{0ex}}\mathrm{K}$, the frequency dependence of which is found to be similar to that for metal-dielectric composites. The ac conductivity obeys the same scaling relation as that of disordered solids, which is quantitatively consistent with a theoretical calculation for spatially inhomogeneous conductive medium. This implies that the charge carrier on the ${\mathrm{Co}}^{2+}$ site is electronically segregated in the $\mathrm{Co}{\mathrm{O}}_{2}$ plane. This compound can work as a metal-dielectric composite even in a form of single crystal, a possible mechanism of which is suggested on the basis of the electronic configuration of Co ions.
New effects of trench isolated transistor using side-wall gates (1987)

In order to realize a high performance switching transistor, a new trench isolated transistor with side-wall gates has been developed. In this transistor with a triple-gate structure, the side-wall of the trench is used as an extra-channel region. The new effects of trench isolated transistor with a triple-gate structure have been described. The advantages of this transistor are excellent cutoff characteristics, a small substrate bias effect and high reliability characteristics. It is found that the side-wall gate along the channel edge plays an important role for increasing the gate controllability and for decreasing the concentration of the electric field at the drain.
The future of wireless communications - is it working out as planned? (2008)

Predictions of the future are interesting but perhaps even more so is looking at previous predictions, comparing them with what actually happened and understanding the reasons for any differences. Early in 2006 I published a book with a detailed forecast for the future. Now, two years later, there are already some divergences from the forecast such as the impact of the iPhone, the early emergence of femtocells and the apparent strong interest in 4G and related technologies. This presentation will summarise the predictions made in 2006, look at the divergences since then and understand why these have occurred and what they might mean for the future.
Bactericidal Action of Photo-Irradiated Aqueous Extracts from the Residue of Crushed Grapes from Winemaking (2016)

Our previous studies revealed that photo-irradiation of polyphenols could exert bactericidal action via reactive oxygen species (ROS). In the present study, the photo-irradiation-induced bactericidal activity of the aqueous extract from the residue of crushed grapes from winemaking was investigated in relation to ROS formation. Staphylococcus aureus suspended in the extract was irradiated with LED light at 400 nm. This solution killed the bacteria, and a 3-4 log and a >5-log reduction of the viable counts were observed within 10 and 20 min, respectively. LED light irradiation alone also killed the bacteria, but the viable counts were 2-4 log higher than those of the photo-irradiated extract. In contrast, almost no change occurred in the suspension without LED irradiation. When hydroxyl radical scavengers were added to the suspension, the bactericidal effect of the photo-irradiated extract was attenuated. Furthermore, electron spin resonance analysis demonstrated that hydroxyl radicals were generated by the photo-irradiation of the extract. The present study suggests that polyphenolic compounds in the extract exert bactericidal activity via hydroxyl radical formation upon photo-irradiation.
Automating supply-chain management (2002)

This paper explores a linguistic approach to coordination modeling as a formal basis for supply-chain management (SCM) in manufacturing. The approach promotes the interchange of standard documents: enterprises need only describe their supply processes using OAG business object documents and UML interaction diagrams. Our methodology and tools analyze the documents and interactions in terms of four linguistic primitives and convert the diagrams into specifications and implementations of software agents. The agents then cooperate in automating the resultant supply chain. We evaluate our methodology in the context of several industrial scenarios. We conclude that supply-chain automation using software-agent technology is feasible.
Extension of spectral domain phase microscopy to three-dimensional nanoscale displacement mapping in cardiomyocytes (2008)

Spectral domain phase microscopy (SDPM) is a functional extension of optical coherence tomography (OCT) whose common-path interferometric design enables phase-referenced imaging of dynamic samples. Like OCT, axial resolution in SDPM is determined by the source coherence length, while lateral resolution is limited by diffraction in the microscope optics. Nonetheless, the quantitative phase information SDPM generates is sensitive to sub-Angstrom displacements of scattering structures. Integrative quantitative phase imaging techniques, such as Fourier phase microscopy, Hilbert phase microscopy, and Digital holographic microscopy, have achieved sub-micron motion detection in live cells. In contrast with the techniques, SDPM can achieve full depth discrimination, allowing for resolution of the motion of independent, sub-cellular structures at various cross-sectional planes within the sample. The ability of SDPM to measure Doppler flow in single-celled organisms, time-resolved cellular motions, and rheological information of the cytoskeleton has been previously demonstrated. The objective of this study is to extend the use of SDPM to produce three-dimensional reconstructions of the internal and surface motions of beating cardiomyocytes. Phase information is used to the motion of quantify cellular structures in the axial dimension. Our gated acquisition process involves synchronization of the SDPM detection system with and applied electrical field used to stimulate beating in isolated cardiomyocytes. For a given pacing protocol, we obtain repeat motion measurements in two-dimensions during cellular contraction, building a volume image by repeating the process at multiple discrete slices through the cell. This experiment serves as a proof-of-principle for volumetric imaging of beating cardiomyocytes.
Direct Growth of Carbon Nanotubes on ZnO(0001) Substrate Surface using Alcohol Gas Source Method in High Vacuum (2012)

Using an alcohol gas source method, carbon nanotubes (CNT) were grown on a ZnO(000) surface without any underlayers. At 700 °C under an ethanol pressure of 1×10-1 Pa, high-density CNTs could be grown using a Co catalyst. However, after the growth, the ZnO surface became rough, accompanied by the occurrence of striped structures along the a-axis. Reducing the growth temperature and ethanol pressure and using a Pt catalyst, CNT growth could be achieved on the ZnO(000) face without the formation of surface roughness. The reaction between the catalyst and the ZnO surface was also investigated using X-ray photoelectron spectroscopy.
A new approach to constrained open pit pushback design using dynamic cut-off grades (2014)

An integral part of open pit optimization is deciding which section of the ultimate pit to mine during a specific period. For a given period there are often operational and marketing constraints that restrict what can be removed or processed. The operational constraints arise from a number of different limitations such as safe slope of internal mining walls, mill and mining capacity. Traditional methods for pushback (phase) design that incorporate these constraints are ad-hoc and can lead to suboptimal solutions. Another important optimization decision that must be made is the cut-off grade to be used for a specific period. In this paper, a new method is presented that generates near maximal expected profit and dynamically defines the optimal cut-off grade for each mining period or pushback over the life-of-mine, thus deciding whether a block is ore or waste during the optimization process. More specifically, a method for converting a fractional linear program solution into an integral solution known as pipage rounding is applied to an integer program formulation of a pushback design optimization problem. The proposed method aims to produce a set of pushbacks in a way that the total discounted profit to be generated through production scheduling is maximized. Two case studies demonstrate the applied aspects of the proposed method.
Depth map generation from a single image using local depth hypothesis (2012)

This paper proposes an interactive method of depth map generation from a single image for 2D-to-3D conversion. First, the proposed method groups an input image into similar regions to preserve details and segments the image into salient regions with user interaction. Then, the proposed method generates local depth hypothesis using structural information of the input image and salient regions. Finally, the proposed method generates depth map using local depth hypothesis and grouped regions. Experimental results show that the proposed method gives more natural depth map in terms of human perception. It can be applied to depth image based rendering such as stereo view rendering.
Normal modes and stability of phase-separated trapped Bose-Einstein condensates (2003)

We study the normal modes and the stability of two component condensates in a phase separated regime. In such a regime, the system can undergo a quantum phase-transition upon the change of interaction strength between bosons of the same species or the variation of the trap frequencies. In this transition, the distribution of the two components changes from a symmetric to an asymmetric shape. We discuss the nature of the phase transition, the role of the interface tension, and the phase diagram. The symmetric to asymmetric transition is the simplest quantum phase transition that one can imagine. We found new branches of normal modes which are specific for trapped multicomponent condensates and are analogous to the waves at the interface between two layers of immiscible fluids under gravity. At the point of the phase transition, the frequencies of those modes go to 0 and become imaginary which causes an instability. The interface tension shifts the normal-mode frequencies and changes the stability region of the system.
Phase II, multicenter, open-label, non-randomized study of neoadjuvant chemotherapy NALIRINOX (5-FU/LV + oxaliplatin + nal-IRI) followed by chemoradiotherapy in patients with rectal cancer in a watch-and-wait program. (2022)

3612 Background: Despite optimal treatment sequence are still challenging, Neoadjuvant chemotherapy (NAC) followed by chemoradiotherapy (CRT) in patients with local rectal cancer (LRC), known as total neoadjuvant therapy (TNT), offers early treatment of micrometastases, with optimal exposure to systemic chemotherapy (CT) and rapid relief of local symptoms. In one hand, Nal-IRI has demonstrated efficacy and safety in the treatment of GI tumors. On the other hand, Watch and Wait (W&amp;W) protocol is currently being imposed as an alternative to surgery in selected patients with LCR who achieve complete clinical response (cCR), offering the possibility of a rectum preservation strategy without the need to surgical intervention. Accordingly, TNT with NAC Nal-IRI, 5-FU, Oxaliplatin (NALIRINOX) could help to increase cCR rates in LRC treatment, allowing to enter W&amp;W protocol. Methods: We performed a national, single arm, multicenter phase II study of patients with LRC treated with biweekly NAC NALIRINOX for 8 cycles followed by CRT. Main inclusion criteria were patients with confirmed histopathological diagnosis of LRC, good performance status and candidates for W&amp;W protocol. Primary objective was the % of cCR rate obtained. Secondary objective was safety profile of NAC NALIRINOX combination. The first reassessment was carried out at 10 +/- 2 weeks after finish CRT, with digital rectal examination (DRE), pelvic MRI, CT body scan and rectoscopy. The results were evaluated and discussed by the multidisciplinary gastrointestinal Tumors Board (including Radiological Oncology, Medical Oncology, Surgery, Gastroenterology, Nuclear Medicine, Radiology and Pathology Departments) If patient achieved cCR, was included in W&amp;W protocol with close follow-up with the same tests. Results: 30 subjects with LRC were recruited between March 2019 and July 2020 (22 men and 8 women); 26 (86.7%) subjects received 8 NAC NALIRINOX cycles. 1 subject received only 1 cycle, 2 subjects received 3 cycles and 1 received 7 cycles. A total of 25 (83.3%) subjects were evaluated for either W&amp;W or surgery after CRT. 10 of them (45.5%) underwent surgery: 5 (50%) Low anterior resection (LAR) and 4 (40%) Abdominoperineal resection (APR). Therefore, 12 (54.5%) obtained cCR after first reassessment and underwent W&amp;W protocol surveillance. Regarding safety endpoint, 6 (20%) subjects reported at least one grade 3 CTCAE toxicity related to any of the NALIRINOX medications. Diarrhea was the most frequent (13.3%), followed by asthenia (3.3%) and decreased appetite (3.3%). All of them had been resolved. Conclusions: TNT with NAC NALIRINOX is a safe and effective therapeutic approach to increase cCR rates and enable to select patients with LRC for W&amp;W protocols Clinical trial information: NCT04009876.
High-Performance Control for a Bearingless Permanent-Magnet Synchronous Motor Using Neural Network Inverse Scheme Plus Internal Model Controllers (2016)

This paper proposes a novel decoupling scheme for a bearingless permanent-magnet synchronous motor (BPMSM) to achieve fast-response and high precision performances and to guarantee the system robustness to the external disturbance and parameter uncertainty. The proposed control scheme incorporates the neural network inverse (NNI) method and 2-degree-of-freedom (DOF) internal model controllers. By introducing the NNI systems into the original BPMSM system, a decoupled pseudo-linear system can be constituted. Additionally, based on the characteristics of the pseudo-linear system, the 2-DOF internal model control theory is utilized to design extra controllers to improve the robustness of the whole system. Consequently, the proposed control scheme can effectively improve the static and dynamic performances of the BPMSM system, as well as adjust the tracking and disturbance rejection performances independently. The effectiveness of the proposed scheme has been verified by both simulation and experimental results.
Investigation of ion binding properties of synthetic polyelectrolytes using a terbium(III) probe: elucidation of the number of coordinated water molecules on metal polyelectrolyte complexes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of ion binding properties of synthetic polyelectrolytes using a terbium(III) probe: elucidation of the number of coordinated water molecules on metal polyelectrolyte complexesJ. Kido, H. G. Brittain, and Y. OkamotoCite this: Macromolecules 1988, 21, 6, 1872–1875Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ma00184a058https://doi.org/10.1021/ma00184a058research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ORBiT: Oak Ridge biosurveillance toolkit for public health dynamics (2015)

These quantitative insights show how the claims data combined with novel analytical techniques can provide important information to decision makers when an epidemic spreads throughout the country. Taken together ORBiT provides a scalable and extensible platform for public health surveillance.
SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS (2022)

Abstract Mobility impairment is the most common disability among older adults, with an earlier presentation, higher prevalence, and greater severity in women compared to men. A decline in skeletal muscle metabolism contributes to the loss of mobility with age. However, it is unknown if sex-specific differences in muscle energetics can explain the disparity in mobility impairment among men and women. In the Study of Muscle, Mobility, and Aging (SOMMA), muscle energetics was characterized using in vivo Phosphorus Magnetic Resonance Spectroscopy and High-Resolution Respirometry of permeabilized fiber bundles from muscle biopsies. In this analysis of 773 participants aged 70–94 years, 519 were women, of which 16% were deemed lower extremity mobility impaired based on a Short Physical Performance Battery (SPPB) score
Chemical Looping Reforming of Glycerol for Continuous H2 Production by Moving-Bed Reactors: Simulation and Experiment (2020)

Chemical looping reforming of biomass is a promising avenue for hydrogen generation. Both the design of reactor configurations and the screening of oxygen carriers represent major challenges in chemical looping technologies. Here, we synthesize three oxygen carriers (referred to as Ni–Al, NiW–Al, and W–Al) by a continuous coprecipitation method and first test them in a fixed-bed reactor. The NiW–Al showed the highest coke resistance, reducibility, and glycerol conversion. We employ an Ellingham diagram to explain the superior performance of the NiW–Al and screen operational temperatures from the standpoint of thermodynamics. Then, using the NiW–Al oxygen carriers, we investigate the effect of Ni-to-glycerol ratio, fuel reactor temperature, and steam-to-glycerol ratio in moving-bed reactors. Establishing two sets of five-stage equilibrium models in Aspen Plus, we compare the experimental results with simulations, discovering good agreement with each other. An isothermal and coke-free operational window was optimized at a fuel reactor temperature of 650 °C, a Ni-to-glycerol ratio of 0.9, and a steam-to-glycerol ratio of 4.5, achieving an average H2 yield of 1.5 mol-H2/mol-C. This work highlights the promise of combining moving-bed reactors with oxygen carriers with high oxygen storage capacity to utilize biomass by chemical looping reforming for continuous H2 generation.