gebhart/patrepeval huggingface dataset:
Synthesis of 3-N-Sugar-substituted-2, 4(1H,3H)-quinazolinedionesas Anti-Angiogenesis Agents (2009)

A series of novel 3-N-sugar-substituted quinazolinediones were synthesizedthrough the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.
Characterization of an anaerobic soil enrichment capable of dechlorinating high concentrations of tetrachloroethylene (1997)

An anaerobic soil enrichment culture could dechlorinate high concentrations of tetrachloroethylene (PCE; 150 mg/liter nominal concentration; approximately 58 mg/liter in aqueous concentration) nearly stoichiometrically to cis-1,2-dichloroethylene (cis-DCE) via trichloroethylene (TCE) at high rates; a maximum dechlorination rate was 0.4 μmol of PCE transformed/mg volatile suspended solids per hr, using citrate as an electron and carbon source and yeast extract as a nutritional requirement. This dechlorinating activity was comparable with those of the previously-reported, efficient bacterial cultures. Some substrates such as pyruvate, succinate, formate, acetate, and acetate with H2 could replace citrate but propionate could not, and yeast extract could be replaced by a vitamin mixture. However the PCE dechlorination rate decreased more than threefold by the addition of the vitamin mixture, suggesting that the vitamin mixture could not be a complete supplement for the nutritional requirement. Optimal pH and temperature of the enrichment for PCE dechlorination were 7 and 30 °C, respectively. Dechlorination of PCE was completely inhibited by the addition of NO3− and NO2− as potential alternative electron acceptors. S2O3−2 and SO3−2 delayed PCE dechlorination but SO4−2 had no significant effect on PCE reduction. 2-bromoethanesulfonic acid (BES, an inhibitor of methanogenesis) also showed no influence on PCE dechlorination, suggesting methanogens were not concerned with PCE removal in this enrichment. Further, microbial investigations on the enrichment showed that it contains four types of bacteria; cocci, large rods, curved rods, and small rods. The small rods seemed to nutritionally support the PCE dechlorinating bacteria, presumably the curved rods.
Twisted polymers: Structural reorganization in macromolecular network through metal ion coordination (1979)

The alkylation of flexible styrene–divinylbenzene copolymer, with 5-chloromethyl-8-hydroxyquinoline in the “impregnated” dry state in the presence of aluminum chloride in nitrobenzene, is accompanied by structural reorganization. The polymer external shape is twisted and the internal structure constringes or expands, according to the impregnation method. The process of the “twist” polymer formation can be explained by the coordination of aluminum ions by the oxine ligand concurrently with the alkylation.
Haplotypes of G Protein–coupled Receptor 154 Are Associated with Childhood Allergy and Asthma (2005)

Our results indicate that polymorphisms and haplotypes in the haplotype block of GPR154 are associated with asthma, rhinoconjunctivitis, and sensitization in European children.
The workload of web-based consultations with atopic eczema patients at home (2010)

Individual web-based follow-up of atopic eczema patients at home is feasible. The amount of time needed for the doctor to respond to a request from the patient appears to be small. The answering time seems to depend on whether photographs are supplied and also on seasonal variations of disease activity. Since the management of atopic eczema is complex involving many different types of treatments and educational aspects, we expect this type of communication to be useful also to other chronic disease patients requiring close follow-up.
Are G3 ENETS neuroendocrine neoplasms heterogeneous? (2013)

The new WHO classification of gastroenteropancreatic (GEP) neuroendocrine tumors (NET) implies that G3 neoplasms with mitotic index >20 and/or Ki67 index >20% are neuroendocrine carcinomas (NEC), described as poorly differentiated, small or large cell types, by analogy with lung NEC. To characterize the subgroup of non-small-cell-type GEP and thoracic NET with mitotic index >20 and/or Ki67 >20% according to their pathological features, response to cisplatin and overall survival (OS). We reviewed pathological and clinical presentation of G3 non-small-cell-type NET referred to our institution for 5 years. Data from 166 patients with metastatic thoracic and GEP-NET were collected. Twenty-eight patients (17%) fulfill the inclusion criteria. Tumors were classified as well-differentiated NET (G3-WDNET) in 42.8% of cases and poorly differentiated, large-cell NEC (G3-LCNEC) in 57.2% of cases. Plasma chromogranin A or neuron-specific enolase were elevated in 42 and 25% respectively of G3-WDNET and 31 and 50% of G3-LCNEC. Somatostatin receptor scintigraphy was positive in 88 and 50% of G3-WDNET or G3-LCNEC respectively. Complete or partial response to cisplatin was observed in 31% of cases, all classified as G3-LCNEC. The median OS was 41 months for G3-WDNET but 17 months for G3-LCNEC (P=0.34). Short survival was observed in 25% of G3-WDNET but 62.5% of G3-LCNEC patients (P=0.049). G3 ENETS GEP and thoracic neuroendocrine neoplasms (NEN) could constitute a heterogeneous subgroup of NEN as regards diagnosis, prognosis, and treatment. If confirmed, future classifications may consider splitting them into two groups according to their morphological differentiation.
Diastereoselective IBX Oxidative Dearomatization of Phenols by Remote Induction: Towards the Epicocconone Core Framework (2011)

The IBX twist does it: Towards the synthesis of a recently isolated dihydropyranic azaphilone core framework, a 2-iodoxybenzoic acid (IBX)-mediated oxidative dearomatization was performed on a bicyclic substrate with excellent diastereoselectivity. Trifluoroacetic acid (TFA) esters were obtained as single diastereomers and water was shown to increase both the speed and diastereoselectivity of the reaction (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Modelling and estimation of gear train backlash present in wind turbine driven DFIG system (2018)

The backlash, which is always present in the gears of drive‐trains to enable smooth operation, may increase with time due to the wear and tear during mechanical power transmission. Accurate knowledge of the amount of backlash non‐linearity is required in such systems for monitoring control applications as well as developing maintenance strategies. In this study, the modelling and online estimation of the backlash existing in the gear train of wind turbine driven doubly fed induction generator (DFIG) systems is presented. The estimation has been performed using the unscented Kalman filter considering the backlash as a parameter and augmenting it as a state into the dynamics. Local measurements of the DFIG system have been used to estimate the backlash. The performance and efficacy of the method have been investigated in different scenarios viz. system parameters, noise levels of the measurements and operating points of the DFIG system. The estimation has also been performed in an environment of the time‐varying wind, modelled by Van der Hoven's spectral model. The estimation has been enabled by the bad‐data detection and examined in the presence of unknown mechanical parameters of the shaft.
Selecting the Right Data Distribution Scheme for a Survivable Storage System (CMU-CS-01-120) (2018)

Survivable storage system design has become a popular research topic. This paper tackles the difficult problem of reasoning about the engineering trade-offs inherent in data distribution scheme selection. The choice of an encoding algorithm and its parameters positions a system at a particular point in a complex trade-off space between performance, availability, and security. We demonstrate that no choice is right for all systems, and we present an approach to codifying and visualizing this trade-off space. Using this approach, we explore the sensitivity of the space to system characteristics, workload, and desired levels of security and availability. This research is part of the PASIS project at Carnegie Mellon University.
Pelanserin inhibition of serotonin‐induced phosphatidylinositol turnover and contraction in rabbit aorta (1991)

Abstract Stimulation of rabbit aortic rings with serotonin or quipazine increased the incorporation of [ 32 P]Pi into phosphatidylinositol (Pl) and induced a dose‐related contraction. The effects of serotonin and quipazine were blocked by 5‐HT 2 antagonists with the following order of potency: pelanserin = ketanserin ≫ methysergide. Indorenate, a 5‐HT 1 agonist, failed to modify phosphatidylinositol labeling in rabbit aorta but elicited a very weak contraction at high concentrations. Pelanserin blocked epinephrine‐stimulated phosphatidylinositol labeling, being two orders of magnitude less potent than prazosin. The results demonstrate that pelanserin is a potent antagonist of the stimulation of Pl labeling and vasoconstrictor effects of 5‐hydroxytryptamine and suggest that 5‐HT 2 blockade is involved as its major pharmacologic action.
Automated cognitive modeling with Bayesian active model selection. (2019)

Behavioral experiments are often feed-forward: they begin with designing the experiment, and proceed by collectingthe data, analyzing it, and drawing inferences from the results. Active learning is an alternative approach where partialexperimental data is used to iteratively design subsequent data collection. Here, we study experimental application ofBayesian Active Model Selection (BAMS), which designs trials to discriminate between a set of candidate models. Weconsider a model set defined by a generative grammar of Gaussian Process kernels that can model both simple functionsand complex compositions of them. To validate the method experimentally, we use BAMS to discover how factors suchas contrast and number affect numerosity judgements. We compare the rate of convergence of the active-learning methodto a baseline passive-learning strategy that selects trials at random. Active learning over a structured model space mayincrease the efficiency and robustness of behavioral data acquisition and modeling.
Fish-scales: representing fuzzy manifolds (2002)

We address the problem of automatically reconstructing m-manifolds of unknown topology from unorganized points in metric p-spaces obtained from a noisy measurement process . The point set is first approximated by a collection of oriented primitive fuzzy sets over a range of resolutions. Hierarchical multiresolution representation is then computed based on the relation of relative containment defined on the collection. Finally, manifold structure is recovered by establishing connectivity between these primitives based on proximity, compatibility of position and orientation and local topological constraints. The method has been successfully applied to the problem of surface reconstruction from polynocular-stereo data with many outliers.
Chairman's corner (1987)

It's Fall again, the re-start of the cycle that seems to govern the lives of all of us in the academic world. There are many cycles in the lives of both people and institutions; the academic year is one of the most conspicuous to us.
THE MAKING OF TITANIUM AND TITANIUM-ALLOY SHAPES BY CASTING, POWDER METALLURGY, AND OTHER PROCESSES, (1966)

The state of the art of making titanium and titanium-alloy shapes by methods other than machining from wrought materials is reviewed. The methods covered are casting, powder metallurgy, metal spraying, electroforming and chemical vapor deposition. Of these methods only casting and powder metallurgy are being used to any great extent or offer a great deal of promise. Metal spraying may have some very specialized applications. In their present state of development electroforming and chemical vapor deposition are not promising methods for making titanium parts. (Author)
Elimination du rayonnement arrière d'une antenne spirale (2013)

National audience
Slowing of the Atrial Flutter Rate During 1:1 Atrioventricular Conduction in Humans and Dogs: An Effect Mediated Through Atrial Pressure and Volume (1992)

Atrial Flutter Rate and Atrial Pressure . Introduction : During atrial flutter the effects of 1:1 atrioventricular (AV) conduction on the rate of atrial flutter was studied in 12 patients and 14 dogs. Methods and Results : (A) In all patients, the development of 1:1 AV conduction was associated with a significant increase in flutter cycle length (261.7 ± 9.9 to 281.8 ± 12.1 msec, mean increase 20.3 ± 3.2 msec, P &lt; 0.001). The flutter cycle length returned to control values when 1:1 AV conduction ceased. In four patients in whom atrial pressure was monitored, the prolongation of the atrial flutter cycle interval during 1:1 AV conduction was associated with an immediate rise in atrial pressure (4.0 ± 0.4 to 6.5 ±0.7 mmHg, P &lt; 0.003). (B) In order to examine the mechanism of this phenomenon, similar studies were carried out in dogs with experimentally induced atrial flutter. 1:1 AV conduction consistently lengthened the flutter cycle length during control conditions or following vagotomy and during the administration of isoproterenol. This was always associated with a rise in atrial filling pressure. Inferior vena cava occlusion consistently shortened the flutter cycle length and this was also independent of vagotomy and isoproterenol administration. The atrial filling pressure fell during inferior vena cava occlusion. During 1:1 AV conduction, the prolonged flutter cycle length was shortened by inferior vena cava occlusion to values prior to 1:1 AV conduction. Conclusion : The rate of atrial flutter is accelerated by reductions in atrial pressure, and slowed by increased atrial pressure. These effects are independent of the vagus nerve or an adrenergic agonist. Changes in atrial pressure and volume affect characteristics of the atrial flutter circuit, and thus can modulate the rate of atrial flutter.
Ethanol precipitation to concentrate DNA excised from agarose gel. (1990)

A reaction mixture containing DNA excised from a gel can be concentrated by ethanol precipitation without prior purification. The above-described experiment illustrates one of the possible uses of the «in-gel» ethanol precipitation of DNA fragments. This modification greatly extends the applicability of the «in-gel» DNA manipulation techniques
Numerical Study of the Precessing Vortex Core in a Confined Partially Premixed Swirl Combustion System (2007)

Swirl flows play an important role in modern combustion systems such as gas turbines, aero propulsion systems etc. Next to desirable effects such as enhanced mixing such flows often exhibit aerodynamical instabilities called precessing vortex core. The configuration under study here represents a model Gas Turbine(GT) combustion chamber and features the main properties of real gas turbine combustors: a confined swirled flow with multiple recirculation zones and reattachment points, resulting in reacting case in a partially premixed methane/air aerodynamically stabilised flame. This flame exibits also precessing vortex core (PVC). The present study especially concentrates on an evaluation of the performance of different URANS-based model-combinations in predicting this confined swirling reacting flow exhibiting such aerodynamic instabilities. For this purpose an extended Bray-Moss-Libby model and a G-equation based approach, both coupled to the mixture fraction transport equation to account for partially premixed effects, are applied. Their prediction potential in capturing partially premixed combustion properties is appraised by comparison with LDV, Raman and PLIF measurements. It turns out that the influence of the combustion model on simulation results of the flame front stabilisation or mean flow field is not obvious. Nevertheless it could be mentioned that the computation time with G-equation was approximately three times longer than with BML model due to the reinitialization needed in steady case calculations and 2 times longer in case of unsteady calculations.
Generation of \c{hi}2 solitons from the Airy wave through the parametric instability (2015)

Spontaneous creation of solitons in quadratic media by the downconversion, i.e., parametric instability against the generation of fundamental-frequency excitations, from the truncated Airy-wave (AW) mode in the second-harmonic component is studied. Parameter regions are identified for the generation of one, two, and three solitons, with additional small-amplitude "jets". Shares of the total power carried by individual solitons are found. Also considered are soliton patterns generated by the downconversion from a pair of AWs bending in opposite directions.
Suppression and recovery of quantum Hall plateaus in a parabolic quantum well (1991)

The magnetotransport of a narrow (75-nm) parabolic well reveals suppressed quantum-Hall states at even-integer filling factors. The width of the parabolic well and the sheet carrier density determine which quantum Hall plateaus are observed. The observed behavior is explained by the influence of the magnetic field on the subband structure of the well.
War, culture, and the interpretation of history: The Vietnam War reconsidered (1998)

Cultural ignorance of Vietnam was the greatest US failing during the Vietnam War and has not been corrected in conflicts since. The article analyses opposing verdicts on the war. It compares the American Clausewitzian approach to war with the much longer Vietnamese tradition summed up in the writings of Truong Chinh, a leading theoretician of the Vietnamese Communist Party. His two books were available in English in the 1960s. Attitudes at the time are described to show the US failure to understand the kind of war that Hanoi waged until final victory in 1975.
Single spectrum three-material decomposition with grating-based x-ray phase-contrast CT (2020)

Grating-based x-ray phase-contrast imaging provides three simultaneous image channels originating from a single image acquisition. While the phase signal provides direct access to the electron density in tomography, there is additional information on sub-resolutional structural information which is called dark-field signal in analogy to optical microscopy. The additional availability of the conventional attenuation image qualifies the method for implementation into existing diagnostic routines. The simultaneous access to the attenuation coefficient and the electron density allows for quantitative two-material discrimination as demonstrated lately for measurements at a quasi-monochromatic compact synchrotron source. Here, we investigate the transfer of the method to conventional polychromatic x-ray sources and the additional inclusion of the dark-field signal for three-material decomposition. We evaluate the future potential of grating-based x-ray phase-contrast CT for quantitative three-material discrimination for the specific case of early stroke diagnosis at conventional polychromatic x-ray sources. Compared to conventional CT, the method has the potential to discriminate coagulated blood directly from contrast agent extravasation within a single CT acquisition. Additionally, the dark-field information allows for the clear identification of hydroxyapatite clusters due to their micro-structure despite a similar attenuation as the applied contrast agent. This information on materials with sub-resolutional microstructures is considered to comprise advantages relevant for various pathologies.
What experience teaches us about incrustation (1971)

Most commonly, the cause of a decrease in well capacity is clogging of the water-bearing formation around the well bore and clogging of the openings in the well screen. This occurrence is called incrustation. Two acids commonly used to remove mineral incrustants are sulfamic and hydrochloric (muriatic). Calcium carbonate is readily dissolved by both hydrochloric and sulfamic acid. However, these acids attack iron incrustants rather slowly, especially sulfamic acid. Generally, more than 90% of mineral incrustation problems are either caused by calcium carbonate or ferrous or ferric hydroxide. Incrustation due to manganese and magnesium carbonate deposition is rare. Also rare is incrustation from calcium sulfate. Bacterial plugging is commonly caused by organisms known as iron bacteria. Iron bacteria and plugging caused by it are generally found in shallow waters, probably because the bacteria are aerobic; in waters at temperatures of 65$ or less; in high iron and manganese water; and in waters with less than 1,000 ppm total dissolved solids. Iron bacteria problems are not capable of being solved permanently, but they can be arrested and somewhat controlled with the use of chlorine. Sulfate-reducing bacteria are anaerobic organisms which reduce sulfate to sulfide. Sulfide combines with hydrogen in the watermore » to become hydrogen sulfide.« less
Phenylated Polyimidazopyrrolones (1980)

Polyimidazopyrrolones have been shown to retain useful mechanical properties at elevated temperatures, after severe chemical treatment, and after unusually high exposure to ionizing radiation (1,2). Although this combination of properties suggests numerous potential aerospace applications, no practical uses for these polymers have emerged. This is primarily due to difficulties associated with their fabrication that result from their extremely high Tg's and their very limited solubilities. One approach to obtaining solubility in linear aromatic polymers has been to incorporate pendent phenyl groups along the polymer backbone. For example, phenylated polyphenylenes (3) and phenylated polyquinoxalines (4,5) are soluble in common organic solvents, which is in marked contrast to the insolubility displayed by their parent polymers. Soluble phenylated polyimides have been prepared in this laboratory by the polymerization of phenylated dianhydrides with aromatic diamines (6,7). The objective of this research was the synthesis of phenylated polyimidazopyrrolones. The approach involved the polymerization of a
La Bibliothèque universelle des romans, 1775-1789. Présentation, table analytique et index (1985)

I. Presentation: gestion et abonnements. Libraires et reimpressions. Public et redacteurs. Classes et series: romans de chevalerie, historiques, moraux... Principes et theories. Chiffres et proportions: pays representes, epoques litteraires... Librairie et presse periodique. Table analytique (pp. 47-248). Index des titres d'ouvrages et des noms d'auteur, de traducteur, d'editeur et de libraire. Index des references.
T cell functions of psoriatic arthritis patients are regulated differently by TNF, IL-17A and IL-6 receptor blockades in vitro (2022)

Both TNF and IL-17A blockers are suitable for PsA treatment, but exhibit different activity on T cells. Moreover, the study reveals part of the mechanism exerted by ADA and provides a possible explanation for TCZ inefficacy in PsA.
ChemInform Abstract: Antimicrobial and Cytotoxic Properties of 9,10‐Dihydrophenanthrenes: Structure‐Activity Studies on Juncusol. (1986)

Abstract Die Dihydrophenanthrene (II), (IV) und (V) werden dargestellt und mit ähnlichen Verbindungen auf cytotoxische Aktivität untersucht.
Role of Joshi's External Stabilisation System Fixator in the Management of Idiopathic Clubfoot (2003)

The Joshi's external stabilisation system frame is ideally suited for the child in whom clubfoot deformities remain uncorrected by plaster-of-paris casts and manipulation, as well as for recurrent clubfoot. Casting after complete correction not only protects the osteopenic bones while the pin-tracts heal, but also maintains correction and allows gradual weightbearing.