gebhart/patrepeval huggingface dataset:
The C/EBP bZIP Domain Can Mediate Lipopolysaccharide Induction of the Proinflammatory Cytokines Interleukin-6 and Monocyte Chemoattractant Protein-1 (2000)

C/EBPalpha, beta, and delta are all expressed by bone marrow-derived macrophages. Ectopic expression of any of these transcription factors is sufficient to confer lipopolysaccharide (LPS)-inducible expression of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) to a B lymphoblast cell line, which normally lacks C/EBP factors and does not display LPS induction of proinflammatory cytokines. Thus, the activities of C/EBPalpha, beta, and delta are redundant in regard to expression of IL-6 and MCP-1. Surprisingly, the bZIP region of C/EBPbeta, which lacks any previously described activation domains, can also confer LPS-inducible expression of IL-6 and MCP-1 in stable transfectants. Transient transfections reveal that the bZIP regions of C/EBPbeta, C/EBPdelta, and, to a lesser extent, C/EBPalpha can activate the IL-6 promoter and augment its induction by LPS. Furthermore, the transdominant inhibitor, LIP, can activate expression from the IL-6 promoter. The ability of the C/EBPbeta bZIP region to activate the IL-6 promoter in transient transfections is completely dependent upon an intact NF-kappaB-binding site, supporting a model where the bZIP protein primarily functions to augment the activity of NF-kappaB. Replacement of the leucine zipper of C/EBPbeta with that of GCN4 yields a chimeric protein that can dimerize and specifically bind to a C/EBP consensus sequence, but shows a markedly reduced ability to activate IL-6 and MCP-1 expression. These results implicate the leucine zipper domain in some function other than dimerization with known C/EBP family members, and suggest that C/EBP redundancy in regulating cytokine expression may result from their highly related bZIP regions.
XMRV, Q fever and other emerging infections: impact on management of blood safety (2011)

As a result of continuous improvement efforts, the blood supply is now extremely safe. However, emerging infections offer a real or potential challenge to such safety. Since 2003, two new tests have been implemented in the United States in order to reduce the risk of transfusion transmission of West Nile virus and Trypanosoma cruzi . In addition, Babesia microti and dengue viruses are considered to be high‐priority threats. Q fever outbreaks in the Netherlands illustrate a localized threat that has been assessed and managed through human and agricultural public health measures and by selective testing of blood donors. The recently recognized gammaretrovirus XMRV has generated scientific and social controversy and illustrates a number of problems in managing blood safety policy.
Structural performance of precast self-compacting concrete beam consisiting banana skin powder and coir fibre under flexural load (2018)

LIHR is an important independent predictive factor for decreasing intraoperative hemorrhage levels and shortening postoperative hospitalization time. Additionally, LIHR does not prolong operation time after the learning curve.
ChemInform Abstract: A SIMPLE AND CONVENIENT PHENOL ANNULATION (1981)

Abstract Cyclohexanon (Ia) wird in das Phenylsulfinyl‐Derivat (Ib) und dann mit den Vinylketonen (II) bzw. (IV) in die kondensierten Phenole (III) bzw. (V) in hohen Ausbeuten übergeführt.
Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment (2018)

Thymic epithelial cells (TEC) are essential for thymocyte differentiation and repertoire selection. Despite their indispensable role in generating functional T cells, the molecular mechanisms that orchestrate TEC development from endodermal progenitors in the third pharyngeal pouch (3<sup>rd</sup> PP) are not fully understood. We recently reported that the T-box transcription factor TBX1 negatively regulates TEC development. Although initially expressed throughout the 3<sup>rd</sup> PP, Tbx1 becomes downregulated in thymus-fated progenitors and when ectopically expressed impairs TEC progenitor proliferation and differentiation. Here we show that ectopic Tbx1 expression in thymus fated endoderm increases expression of Polycomb repressive complex 2 (PRC2) target genes in TEC. PRC2 is an epigenetic modifier that represses gene expression by catalyzing trimethylation of lysine 27 on histone H3. The increased expression of PRC2 target genes suggests that ectopic Tbx1 interferes with PRC2 activity and implicates PRC2 as an important regulator of TEC development. To test this hypothesis, we used Foxn1<sup>Cre</sup> to delete Eed, a PRC2 component required for complex stability and function in thymus fated 3<sup>rd</sup> PP endoderm. Proliferation and differentiation of fetal and newborn TEC were disrupted in the conditional knockout (Eed<sup>CKO</sup>) mutants leading to severely dysplastic adult thymi. Consistent with PRC2-mediated transcriptional silencing, the majority of differentially expressed genes (DEG) were upregulated in Eed<sup>CKO</sup> TEC. Moreover, a high frequency of Eed<sup>CKO</sup> DEG overlapped with DEG in TEC that ectopically expressed Tbx1. These findings demonstrate that PRC2 plays a critical role in TEC development and suggest that Tbx1 expression must be downregulated in thymus fated 3<sup>rd</sup> PP endoderm to ensure optimal PRC2 function.
DSLRIG: Leveraging predictor structure in logistic regression (2019)

Previous research has demonstrated that predictive performance can be improved whenever an undirected graph can be built over the set of predictors for a continuous response and the neighborhood structure is exploited. These methods are extended to a binary outcome in the new doubly sparse logistic regression incorporating graphical structure among predictors (DSLRIG) model. DSLRIG uses a decomposed representation of the regression parameters and encourages sparsity both within and among the groups that contribute to estimation. Compared to conventional regularized methods, DSLRIG offers improved predictive performance and identification of the true non-zero regression coefficients, while retaining their relative ranking.
Entwicklungslinien und -tendenzen in der Neutronenradiographie / Developments and tendencies in neutron radiography / Developpements et tendances a la neutrographie (1977)

Article Entwicklungslinien und -tendenzen in der Neutronenradiographie / Developments and tendencies in neutron radiography / Developpements et tendances a la neutrographie was published on February 1, 1977 in the journal Materials Testing (volume 19, issue 2).
The Role of Objective In Vivo Testing in the Product Development Process (1986)

New products managers are continually confronted by the challenge of coordinating flows of complex information during the product development process. Among the issues faced are unique problems in relating technical design of product attributes to customers' reactions, leading to an improvement of the product's benefits. Ronald Drozdenko and Sidney Weinstein describe a variety of tests which help to assess customers' reactions to products, thus providing information to improve the design or to substantiate advertising claims. The term “objective in vivo” is given to a category of tests which is employed to quantify consumers' evaluation of specific product attributes under controlled, simulated use conditions. This helps to bridge the gap between tests which are designed to measure the physical or functional aspects of new products and tests which measure the consumers' self‐reported, subjective reactions. A test categorization model, illustrative case studies, and test selection criteria are presented.
Long‐term blood vessel removal with combined laser and topical rapamycin antiangiogenic therapy: Implications for effective port wine stain treatment (2010)

With topical RPM application, the frequency of vessel reperfusion was considerably reduced, which implies that combined light and topical antiangiogenic therapy might be a promising approach to improve the treatment efficacy of PWS birthmarks.
Effect of High Physiological Temperatures on NAD+ Content of Green Leaf Mitochondria (Apparent Inhibition of Glycine Oxidation) (1993)

We observed a rapid decline in the rate of glycine oxidation by purified pea (Pisum sativum L.) leaf mitochondria preincubated at 40[deg]C for 2 min. In contrast, exogenous NADH and succinate oxidations were not affected by the heat treatment. We first demonstrated that the inhibition of glycine oxidation was not attributable to a direct effect of high temperatures on glycine decarboxylase/serine hydroxymethyltransferase. We observed that (a) addition of NAD+ to the incubation medium resulted in a resumption of glycine-dependent O2 uptake by intact mitochondria, (b) addition of NAD+ to the suspending medium prevented the decline in the rate of glycine-dependent O2 consumption by pea leaf mitochondria incubated at 40[deg]C, (c) NAD+ concentration in the matrix space collapses within only 5 min of warm temperature treatment, and (d) mitochondria treated with the NAD+ analog N-4-azido-2-nitrophenyl-4-aminobutyryl-3[prime]-NAD+ retained high rates of glycine-dependent O2 uptake after preincubation at 40[deg]C. Therefore, we conclude that the massive and rapid efflux of NAD+, leading to the apparent inhibition of glycine oxidation, occurs through the specific NAD+ carrier present in the inner membrane of plant mitochondria. Finally, our data provide further evidence that NAD+ is not firmly bound to the inner membrane.
In-Plane Fracture Toughness Measurement of Paper (1995)

Paper sheet material has a high toughness and a low yield stress so that linear elastic fracture mechanics is inappropriate to measure its fracture resistance. Experiments have been conducted on single edge-notched tension SE(T) specimens using the J-integral analysis but there are difficulties in identifying the crack initiation, and the Jc value at 0.2 mm crack growth as required by ASTM E813-89 depends on the slope of the JR-curve which may be affected by specimen size and geometry effects. To overcome these problems the essential fracture work concept is applied to paper and an experimental technique developed to evaluate the specific fracture energy using deeply double-edge notched tension DE(T) specimens containing different ligament lengths. With this technique the fracture resistance of papers from hardwood and softwood pulps, the effects of level of bonding and recycling can be compared. It is recommended that the essential fracture work method be used for quality control of paper by the pulp and paper industry.
Interaction of near-IR laser radiation with plasma of a continuous optical discharge (2016)

The interaction of 1.07-μm laser radiation with plasma of a continuous optical discharge (COD) in xenon and argon at a pressure of p = 3–25 bar and temperature of T = 15 kK has been studied. The threshold power required to sustain COD is found to decrease with increasing gas pressure to P t < 30 W in xenon at p > 20 bar and to P t < 350 W in argon at p > 15 bar. This effect is explained by an increase in the coefficient of laser radiation absorption to 20−25 cm–1 in Xe and 1−2 cm–1 in Ar due to electronic transitions between the broadened excited atomic levels. The COD characteristics also depend on the laser beam refraction in plasma. This effect can be partially compensated by a tighter focusing of the laser beam. COD is applied as a broadband light source with a high spectral brightness.
In Situ Methods to Control Emissions from Surface Impoundments and Landfills (1986)

This report presents the results of a two-year study which included laboratory investigations as well as a comprehensive literature review on methods of reducing the rate of emissions of volatile chemicals from surface impoundments and landfills. It presents information on the following in-situ methods which may be employed to reduce emission rates: air supported structures, floating solid objects, shape modification, aerodynamic modification, floating oil and/or surfactant covers and synthetic membranes over landfills. Conclusions are drawn with respect to the suitability of each of the methods under various circumstances and the degree of control which might be expected. The full report was submitted in fulfillment of Cooperative Agreement No. 810856-01-1 by the University of Arkansas under the sponsorship of the U.S. Environmental Protection Agency. This report covers a period from October 1, 1983 to September 30, 1985. The full report is under CR710856. This project summary was developed by EPA’s Hazardous Waste Engineering Research Laboratory, Cincinnati, OH, to announce key findings of the research project that is fully documented in a separate report of the same title (see project report ordering information in box).
A study on XCAP client system for SIP-based IMPP services (2005)

Internet users are rapidly increased and various services which use Internet are invented. IM (instant messaging) and presence service is one of them. IM and presence is looked upon as a major killer application in the field of IP telephony. In this paper, we describe about the standard technologies for SIP-based IMPP service and about XCAP (XML configuration access protocol) technologies. And then we describe service scenarios and models for SIP-based IMPP services. And finally, we suggest authorization policy and resource list manipulation mechanism using XCAP. And suggests XCAP client system. IMPP service is expecting to contribute in new service creation being integrated with various service such as conference and instant messaging services
Interspecies Transmission and Reassortment of Influenza A Viruses in Pigs and Turkeys in the United States (1992)

Genetic reassortment between influenza A viruses in humans and in animals and birds has been implicated in the appearance of new pandemics of human influenza. To determine whether such reassortment has occurred in the United States, the authors compared the genetic origins of gene segments of 73 swine influenza virus isolates (1976-1990), representing 11 states, and 11 turkey virus isolates (1980-1989), representing eight states. The host origin of gene segments encoding the internal proteins of H1N1 swine and turkey influenza viruses was identified by developing a dot-blot assay. All gene segments of swine influenza viruses were characteristic of influenza virus genes from that species, indicating that pigs may not be frequent participants in interspecies genetic exchange and reassortment of influenza viruses in the United States. In contrast, 73% of the turkey influenza virus isolates contained genes of swine origin. One turkey isolate was a reassortant having three genes characteristic of avian influenza virus and three of swine origin. These findings document a high degree of genetic exchange and reassortment of influenza A viruses in domestic turkeys in the United States. The molecular biologic techniques used by the authors should aid future epidemiologic studies of influenza pandemics.
Synthesis and Crystal Structure of 1,4,7-Tris(2-mercaptoethyl)-1,4,7-triazacyclononane (2015)

The title compound, 1,4,7-tris(2-mercaptoethyl)-1,4,7-triazacyclononane (H3tmtacn), was synthesized and the crystal structure was determined by the single-crystal X-ray diffraction method at 293 K. It crystallizes in the monoclinic space group P21/n with a = 9.9553(13)Å, b = 13.7164(19)Å, c = 14.724(2)Å, β = 102.528(2)°, V = 1962.7(5)Å3, Dx = 1.355 g/cm3, and Z = 4. The R1 [I > 2σ(I)] and wR2 (all data) values are 0.0538 and 0.1436, respectively, for all 4528 independent reflections. The triazacyclononane moiety is protonated at the two nitrogen atoms with hydrogen-bonded chloride ions and water molecules as H3tmtacn·2HCl·H2O.
Adipocytes Modulate the Phenotype of Human Macrophages through Secreted Lipids (2013)

Previous studies have shown accumulation and an enhanced proinflammatory profile of macrophages in adipose tissue of obese mice, indicating the presence of an interaction between adipocytes and macrophages in this tissue. However, the consequences of this interaction in humans are yet incompletely understood. In this study, we explored the modulating effects of adipocytes on the phenotype of macrophages in humans and studied the possible molecular pathways involved. Adipocyte-conditioned media (ACM) treatment of macrophages for 48 h strongly reduced the LPS-induced IL-12p40 secretion by macrophages, whereas the production of TNF-α and other cytokines remained largely unaffected. This effect was independent of the source of adipocytes. Interestingly, the level of inhibition correlated directly with body mass index (BMI) of the adipocyte donor. Because adipocytes release many different cytokines, adipokines, and lipids, we have separated the protein and lipid fractions of ACM, to obtain insight into the molecular nature of the soluble mediators underlying the observed effect. These experiments revealed that the inhibitory effect resided predominantly in the lipid fraction. Further studies revealed that PGE2 and linoleic and oleic acid were potent inhibitors of IL-12p40 secretion. Interestingly, concentrations of these ACM-derived lipids increased with increase in BMI of the adipocyte donor, suggesting that they could mediate the BMI-dependent effects of ACM. To our knowledge, these results provide first evidence that obesity-related changes in adipose tissue macrophage phenotype could be mediated by adipocyte-derived lipids in humans. Intriguingly, these changes appear to be different from those in murine obesity.
From “old” photons to “new” photons: advancing new research in photonics and energy (2021)

The <i>Journal of Photonics for Energy</i> (JPE) covers fundamental and applied research areas focused on the applications of photonics for renewable energy harvesting, conversion, storage, distribution, monitoring, consumption, and efficient usage.
Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]Pyrimidine Ribonucleosides (2009)

A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity.
An Adaptive Discontinuous Reception Mechanism Based on Extended Paging Indicator for Power Saving in UMTS (2006)

In this paper, we propose the ADRX (adaptive discontinuous reception) mechanism with the EPI (extended paging indicator) for power saving in the UMTS (universal mobile telecommunications system). Regardless of various traffic patterns and network situations, the conventional FDRX (Fixed DRX) mechanism currently specified by 3GPP (third generation partnership projects) employs only fixed DRX period with a given DRX cycle length of the same length in which each UE (User Equipment) is to have one paging occasion with the uniquely allocated PI. However, improvement of power saving performance cannot be expected since this FDRX does not support longer DRX periods to save more power consumed in the UE for intermittent data packets. In the proposed ADRX mechanism, to solve this problem and efficiently reduce the power consumption, DRX period is easily controlled by the EPI which is decided by Node B considering the current traffic situation. In addition to its original functions to indicate paging messages, the proposed EPI also includes four extended functions; preservation, increase, decrease, and reset of the DRX periods. Simulation results reveal that the proposed ADRX mechanism achieves remarkable improvement of power saving performance as compared to the conventional FDRX mechanism. Furthermore, it is also observed that the proposed ADRX based on the EPI has a trade-off relationship between power saving performance and packet transmission reliability.
Broad Convolutional Neural Network Based Industrial Process Fault Diagnosis With Incremental Learning Capability (2019)

Fault diagnosis, which identifies the root cause of the observed out-of-control status, is essential to counteracting or eliminating faults in industrial processes. Many conventional data-driven fault diagnosis methods ignore the fault tendency of abnormal samples, and they need a complete retraining process to include the newly collected abnormal samples or fault classes. In this article, a broad convolutional neural network (BCNN) is designed with incremental learning capability for solving the aforementioned issues. The proposed method combines several consecutive samples as a data matrix, and it then extracts both fault tendency and nonlinear structure from the obtained data matrix by using convolutional operation. After that, the weights in fully connected layers can be trained based on the obtained features and their corresponding fault labels. Because of the architecture of this network, the diagnosis performance of the BCNN model can be improved by adding newly generated additional features. Finally, the incremental learning capability of the proposed method is also designed, so that the BCNN model can update itself to include new coming abnormal samples and fault classes. The proposed method is applied both to a simulated process and a real industrial process. Experimental results illustrate that it can better capture the characteristics of the fault process, and effectively update diagnosis model to include new coming abnormal samples, and fault classes.
Beyond Tryptophan Synthase: Identification of Genes That Contribute to Chlamydia trachomatis Survival during Gamma Interferon-Induced Persistence and Reactivation (2016)

Chlamydia trachomatis can enter a viable but nonculturable state in vitro termed persistence. A common feature of C. trachomatis persistence models is that reticulate bodies fail to divide and make few infectious progeny until the persistence-inducing stressor is removed. One model of persistence that has relevance to human disease involves tryptophan limitation mediated by the host enzyme indoleamine 2,3-dioxygenase, which converts l-tryptophan to N-formylkynurenine. Genital C. trachomatis strains can counter tryptophan limitation because they encode a tryptophan-synthesizing enzyme. Tryptophan synthase is the only enzyme that has been confirmed to play a role in interferon gamma (IFN-γ)-induced persistence, although profound changes in chlamydial physiology and gene expression occur in the presence of persistence-inducing stressors. Thus, we screened a population of mutagenized C. trachomatis strains for mutants that failed to reactivate from IFN-γ-induced persistence. Six mutants were identified, and the mutations linked to the persistence phenotype in three of these were successfully mapped. One mutant had a missense mutation in tryptophan synthase; however, this mutant behaved differently from previously described synthase null mutants. Two hypothetical genes of unknown function, ctl0225 and ctl0694, were also identified and may be involved in amino acid transport and DNA damage repair, respectively. Our results indicate that C. trachomatis utilizes functionally diverse genes to mediate survival during and reactivation from persistence in HeLa cells.