gebhart/patrepeval huggingface dataset:
Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells (2016)

Members of the NR4A subfamily of orphan nuclear receptors regulate cell fate decisions via both genomic and non-genomic mechanisms in a cell and tissue selective manner. NR4As play a key role in maintenance of hematopoietic stem cell homeostasis and are critical tumor suppressors of acute myeloid leukemia (AML). Expression of NR4As is broadly silenced in leukemia initiating cell enriched populations from human patients relative to normal hematopoietic stem/progenitor cells. Rescue of NR4A expression in human AML cells inhibits proliferation and reprograms AML gene signatures via transcriptional mechanisms that remain to be elucidated. By intersecting an acutely regulated NR4A1 dependent transcriptional profile with genome wide NR4A binding distribution, we now identify an NR4A targetome of 685 genes that are directly regulated by NR4A1. We show that NR4As regulate gene transcription primarily through interaction with distal enhancers that are co-enriched for NR4A1 and ETS transcription factor motifs. Using a subset of NR4A activated genes, we demonstrate that the ETS factors ERG and FLI-1 are required for activation of NR4A bound enhancers and NR4A target gene induction. NR4A1 dependent recruitment of ERG and FLI-1 promotes binding of p300 histone acetyltransferase to epigenetically activate NR4A bound enhancers via acetylation at histone H3K27. These findings disclose novel epigenetic mechanisms by which NR4As and ETS factors cooperate to drive NR4A dependent gene transcription in human AML cells.
Does duration of symptoms affect clinical outcome after hip arthroscopy for labral tears? Analysis of prospectively collected outcomes with minimum 2-year follow-up (2017)

Limited research exists on the possible association between duration of symptoms and clinical outcomes following hip arthroscopy for labral tears. The purpose of this study was to evaluate whether duration of symptoms affected clinical and patient-reported outcome (PRO) scores following hip arthroscopy for labral tears. From 2008 to 2011, data were collected prospectively on all patients undergoing primary hip arthroscopy for labral tears. Workers' compensation cases, dysplasia cases and patients with previous ipsilateral hip surgeries were excluded. A total of 738 patients were identified with a minimum of 2-year follow-up, and clinical and PRO data were available for 680 patients. Uni- and multivariate analyses were performed to determine the relationship between duration of symptoms along with other variables and PROs. Overall, patients experienced significant improvements in all clinical and PRO scores. Results of univariate analysis revealed that all PROs were negatively associated with increasing Log<sub>10</sub> months of symptoms as were pain and satisfaction scores. During multivariate analyses, increasing Log<sub>10</sub> months of symptoms, age, body mass index and trauma were all negatively associated with PROs (<i>P</i> < 0.05). Our study demonstrates that clinical and PRO scores were negatively associated with increasing duration of symptoms prior to hip arthroscopy for treatment of labral tears. Although this implies that delay in treatment may adversely affect outcome, conservative treatment remains the gold standard first line of treatment. Surgeons should incorporate this information into their treatment algorithm to maximize patient outcomes following treatment for labral tears. <i>Level of evidence</i>: Level IV, prospective case series.
Two unusual causes of dysphagia: a pictorial essay. (1987)

Dysphagia was the presenting symptom in two adult patients. One had a mediastinal pancreatic pseudocyst, the other a pulmonary sling. The role of imaging methods in making the diagnoses is illustrated.
Application of OMA to an Operating Wind Turbine: now including Vibration Data from the Blades (2013)

The presented study continues the work on application of Output Only Modal Analysis (OMA) to operating wind turbines. It is known from previous studies that issues like the time-varying nature of the equations of motion of an operating wind turbine (in particular the significant harmonic components due to the rotor rotation) as well as the considerable aerodynamic damping make OMA of operating wind turbines a difficult task. While in the previous works OMA was based on data provided by sensors mounted on the wind turbine tower and nacelle, we here attempt to improve the results by instrumenting the blades as well. It is believed that the availability of vibration data from the blades will improve the observability of the main global vibration modes (especially the heavily damped out-of-plane modes), and thus will assure a better estimation of modal parameters, especially the damping. The paper discusses the technical challenges regarding blade instrumentation and data acquisition, data processing applied to eliminate the time-varying nature of an operating wind turbine in the resulting eigenvalue problem and, finally, it presents and discusses the initial results.
Use of a turbulent mixing CNC to study the influence of composition and vapor properties on heterogenous nucleation (2000)

A new method for changing the supersaturation in the Turbulent Mixing CNC has been developed and used to study the influence of composition and vapor properties on heterogeneous nucleation. Supersaturation was controlled by changing the condensing vapor pressure in nozzle flow by saturating only a predetermined part of the flow while the total flow and temperature remain constant. This approach allows changing the initial vapor pressure while keeping the flow structure and temperature field unchanged. Experimental results for transitions from heterogeneous nucleation to homogeneous nucleation are presented for NaCl and WOx particles at various DBP vapor pressures. With increasing of the DBP vapor pressure, the concentration of enlarged particles increases until it reaches a plateau. At higher initial values of DBP pressure, homogeneous nucleation prevails and the number concentration of particles follows a curve typical for homogeneous nucleation recorded in the absence of nuclei. Nuclei with different mobility diameters were activated at different values of vapor pressure. There are significant differences in the slopes of particle activation curves for NaCl and WOx particles. The reasons for such differences are the subject for continuing research.
Human-Machine Inference Networks For Smart Decision Making:\n Opportunities and Challenges (2018)

The emerging paradigm of Human-Machine Inference Networks (HuMaINs) combines\ncomplementary cognitive strengths of humans and machines in an intelligent\nmanner to tackle various inference tasks and achieves higher performance than\neither humans or machines by themselves. While inference performance\noptimization techniques for human-only or sensor-only networks are quite\nmature, HuMaINs require novel signal processing and machine learning solutions.\nIn this paper, we present an overview of the HuMaINs architecture with a focus\non three main issues that include architecture design, inference algorithms\nincluding security/privacy challenges, and application areas/use cases.\n
Self-inflicted deaths in Australian prisons (2016)

The AIC has operated the National Deaths in Custody Program since 1991, following a recommendation by the Royal Commission into Aboriginal Deaths in Custody. This study updates and extends an earlier AIC study, which examined the important issue of self-inflicted deaths in prison custody using deaths in custody data for the period 1999–2013. Regrettably, suicide remains a common cause of death in prison; however, it is no longer the most common cause of death. While self-inflicted deaths constituted half of all prison deaths between 1980 and 1998, they have declined to the point that between 2004 and 2013—the most recent decade for which data are available—they represented around a quarter of prison deaths. This decrease reflects the considerable progress made by corrective services administrators in developing policies and practices, and implementing cell designs, that address suicide risk factors. Nonetheless, these data and coronial findings suggest there is still room for improvement, particularly in responding to prisoners with psychiatric needs and in the management of unsentenced prisoners.
Dynamic properties of GaInP multielectrode ridge-waveguide lasers (1997)

We investigate the modulation behaviour of GaInP/AlGaInP multielectrode ridge-waveguide lasers. For the first time in this material system, the gain-lever effect is observed, showing a maximum amplitude modulation efficiency enhancement of 5.5 dB for a two-electrode device compared with a conventional single-electrode device. The experimental results show good quantitative agreement with numerical solutions of the two-segment rate equations. The strong dependence of the model on carrier density-dependent input parameters is used to analyse differential gain and carrier lifetime as a function of carrier density. The only fitted input parameter in the theoretical model is the spontaneous radiative recombination coefficient, which is found to be . This value is in good agreement with time-resolved photoluminescence measurements, so the observed effect is clearly explained by the model.
Tactoid Annealing Improves Order in Self-Assembled Cellulose Nanocrystal Films with Chiral Nematic Structures (2017)

The self-assembly process in cellulose nanocrystal (CNC) film formation was studied as a function of evaporation time. It is known that the total evaporation time of CNC dispersions affects the structure of the film obtained, but the extension of different phases of the evaporation has not been explored. By extending the evaporation time of CNC suspensions after the onset of liquid crystallinity, the homogeneity of the resulting films could be improved as observed by polarized optical microscopy and scanning electron microscopy. Here, we show that an intermediate stage of self-assembly, between phase separation and gel vitrification, called tactoid annealing, helps explain the discrepancies in order for chiral nematic CNC films dried at varying evaporation times. This intermediate stage of self-assembly may be useful for designing highly ordered and homogenous CNC-based materials.
Carotid–femoral pulse wave velocity: Impact of different arterial path length measurements (2009)

BACKGROUND: Carotid-femoral pulse wave velocity (PWV) is the most established index of arterial stiffness. Yet there is no consensus on the methodology in regard to the arterial path length measurements conducted on the body surface. Currently, it is not known to what extent the differences in the arterial path length measurements affect absolute PWV values. METHODS: Two hundred fifty apparently healthy adults (127 men and 123 women, 19-79 years) were studied. Carotid-femoral PWV was calculated using (1) the straight distance between carotid and femoral sites (PWV(car-fem)), (2) the straight distance between suprasternal notch and femoral site minus carotid arterial length (PWV((ssn-fem)-(ssn-car))), (3) the straight distance between carotid and femoral sites minus carotid arterial length (PWV((car-fem)-(ssn-car))), and (4) the combined distance from carotid site to the umbilicus and from the umbilicus to femoral site minus carotid arterial length (PWV((ssn-umb-fem)-(ssn-car))). RESULTS: All the calculated PWV were significantly correlated with each other (r=0.966-0.995). PWV accounting for carotid arterial length were 16-31% lower than PWV(car-fem). PWV(car-fem) value of 12 m/sec corresponded to 8.3 m/sec for PWV((ssn-fem)-(ssn-car)), 10.0 m/sec for PWV((car-fem)-(ssn-car)), and 8.9 m/sec for PWV((ssn-umb-fem)-(ssn-car)). CONCLUSION: Different body surface measurements used to estimate arterial path length would produce substantial variations in absolute PWV values.
Neutralizing Murine TGFβR2 Promotes a Differentiated Tumor Cell Phenotype and Inhibits Pancreatic Cancer Metastasis (2014)

Elevated levels of TGFβ are a negative prognostic indicator for patients diagnosed with pancreatic cancer; as a result, the TGFβ pathway is an attractive target for therapy. However, clinical application of pharmacologic inhibition of TGFβ remains challenging because TGFβ has tumor suppressor functions in many epithelial malignancies, including pancreatic cancer. In fact, direct neutralization of TGFβ promotes tumor progression of genetic murine models of pancreatic cancer. Here, we report that neutralizing the activity of murine TGFβ receptor 2 using a monoclonal antibody (2G8) has potent antimetastatic activity in orthotopic human tumor xenografts, syngeneic tumors, and a genetic model of pancreatic cancer. 2G8 reduced activated fibroblasts, collagen deposition, microvessel density, and vascular function. These stromal-specific changes resulted in tumor cell epithelial differentiation and a potent reduction in metastases. We conclude that TGFβ signaling within stromal cells participates directly in tumor cell phenotype and pancreatic cancer progression. Thus, strategies that inhibit TGFβ-dependent effector functions of stromal cells could be efficacious for the therapy of pancreatic tumors. Cancer Res; 74(18); 4996-5007. ©2014 AACR.
Testing the behavior for metamerism of the new deviate observer (JF‐DO) (2005)

Abstract Recently,in our laboratories, a set of color‐matching functions (cmfs) has been formulated for small fields by using two groups of real observers: JAM, MM, CF and AY, JR, MR, JL, JA, FP. The measurements of these cmfs have been made using different experimental devices and methods and it has enabled us to propose a New Deviate Observer for small fields (JF‐DO). This new JF‐DO was derived from the average observer of our nine real observers, following the technique used by the CIE to establish the Standard Deviate Observer (CIE‐1989 SDO), which was established for fields of 10°, despite the CIE's assumption that it can be applied to smaller fields. In the present work, we report experimental results of the JF‐DO using metameric reflectances in comparison to the CIE‐1931 Standard Observer and to the CIE‐1989 SDO. © 2005 Wiley Periodicals, Inc. Col Res Appl, 30, 363–370, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/col.
Prostaglandin E2 Type 1 Receptors Contribute to Neuronal Apoptosis after Transient Forebrain Ischemia (2013)

Cyclooxygenase-2-derived prostaglandin E2 (PGE2) contributes to excitotoxic and ischemic neuronal cell death by engaging neuronal PGE2 type 1 receptors (EP1R). Our previous studies have shown that EP1R signaling resulted in disturbances of intracellular Ca(2+) homeostasis and suppression of the pro-survival protein kinase AKT. The aim of this study was to investigate whether these pathophysiological mechanism have a role in the neuronal cell death after transient forebrain ischemia. Mice were subjected to ischemia/reperfusion by bilateral common carotid artery occlusion. Hippocampal cornu ammonis area 1 (CA1) neuronal cell death was determined 5 days after reperfusion. Animals treated with the EP1R antagonist SC51089 or EP1R-deficient mice (EP1(-/-)) showed significantly less neuronal injury as compared to vehicle-treated wild-type controls. Benefits of EP1R blockage were still evident 14 days after injury. Better neuronal survival was correlated with reduced neuronal caspase-3 activity and decreased nuclear translocation of the apoptosis-inducing factor . Neuroprotection could be reverted by intracerebroventricular administration of the phosphoinositide 3-kinase inhibitor LY294002 and was not further increased by the calcineurin inhibitor FK506. These data implicate EP1R in postischemic neuronal apoptosis possibly by facilitating AKT inhibition.
Systematic Review: Comparative Effectiveness of Core-Needle and Open Surgical Biopsy to Diagnose Breast Lesions (2010)

Agency for Healthcare Research and Quality.
One- and two-step calorimetric studies of crystallization kinetics in simple ionic glass-forming liquids. 1. Calcium nitrate-potassium nitrate system (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOne- and two-step calorimetric studies of crystallization kinetics in simple ionic glass-forming liquids. 1. Calcium nitrate-potassium nitrate systemH. Senapati, K. K. Kadiyala, and C. A. AngellCite this: J. Phys. Chem. 1991, 95, 18, 7050–7054Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/j100171a060https://doi.org/10.1021/j100171a060research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effects of anatomical location on in vivo percutaneous penetration in man (2020)

Regional variability in chemical and drug absorption is of clinical and pharmacological significance. More studies determining <i>in vivo</i> percutaneous absorption in man are necessary to further understand the role of regional variation, the mechanisms involved, and how to derive reliable formulas for extrapolating flux from one anatomic site to the next, often required for risk assessments.
Percutaneous Management of Vascular Complications Following Trans-Subclavian Transcatheter Aortic Valve Replacement (2020)

We present 2 cases that demonstrate the potential for vascular complications following trans-subclavian TAVR and the role of percutaneous intervention in managing such situations.
2211 Thermal Optimization of Semiconductor Structure Using Response Surface Method with Physical Model Transformation (2001)

携帯電話端末等で採用されている高周波デバイスHetero junction Bipolar Transistorでは、ジャンクション温度が高周波特性に対して大きな影響を及ぼす。したがって、エアブリッジの金メッキ長、エミッタフィンガー間のピッチ、GaAs基板の厚さといった形状設計パラメータを熱的に最適化して、熱抵抗を低減する必要がある。本用途に対し、応答曲面法を適用したパラメータ感度解析を行い、チップの幾何形状における設計変数がジャンクション温度に及ぼす影響・感度を明らかにしたので報告する。
Transforming programs into networks : call-graph caching, applications, and examples (2018)

Computer Science Department
Formal properties of the Metathesaurus. (1994)

The Metathesaurus is a machine-created, human edited and enhanced synthesis of authoritative biomedical terminologies. Its formal properties permit it to be a) exploited by computers, and b) modified and enhanced without compromising that usage. If further constraints were imposed on the existence and identity of Metathesaurus relationships, i.e., if every Metathesaurus concept had a "genus" and a "differentia," then the Metathesaurus could be converted into an "Aristotelian Hierarchy." In this sense, a genus is a concept that classifies another concept, and a differentia is a concept that distinguishes the classified concept from all other concepts in the same class. Since, in principle, these constraints would make the Metathesaurus easier to leverage and maintain computationally, it is interesting to ask to what degree the maintenance and enhancement procedures now in place are producing a Metathesaurus that is also an "Aristotelian Hierarchy." Given a liberal interpretation of the current Metathesaurus schema, the proportion of the Metathesaurus that is "Aristotelian" in each annual version is increasing in spite of dramatic concurrent increases in the number of Metathesaurus concepts. Without formality there is no modifiability nor scalability. [1] We need formal methods and computer-based tools that can help us with the task [of controlled medical vocabulary construction]. We need research in which controlled vocabulary development is the focus rather than a stepping stone for work on other theories and applications. [2]
Wear performance of PVD coated tool steels; pp. 202–210 (2012)

The paper describes the performance of high alloy tool steels coated by PVD techniques. Performance evaluation was based on the wear resistance in the conditions of prevalence of adhesion and on tool wear (durability) in the conditions of blanking of electrotechnical sheet steel. Hardmetal (WC-15%Â Co) was used as a primary standard material. It is shown that adhesive wear resistance depends both on the composition of the PVD coating and on that of the tool material to be coated â steels with higher adhesive wear resistance ensure also a higher strengthening effect of the surface. Sharpening of specimens (cutting tools) â removal of coating at the face zone of the tool by grinding â revealed the difference in the efficiency of the coating in different zones of the tool. In terms of durability, thin PVD coatings do not enable improvement of the performance of sheet metal blanking tools (dies, punches). No correlation between durability in blanking and adhesive wear resistance was revealed. In terms of durability prognostication, alloysâ (tool steels, hardmetals, cermets) adhesive wear resistance enables tool life assessment only when materials of similar nature (steels, carbide composites) are compared.
ª¨CAHIERBEI_2003-Volume8-N umero2=® (2003)

Sujets principaux : Europe's changing financial landscape: the financing of small and medium-sized enterprises. SME finance in Europe: introduction and overview; Are finance contraints hindering the growth of SMEs in Europe?; Financing small businesses in France; Small business finance in Italy
Hysteretic behavior of a polymer molecule immersed in an incompatible melt (2000)

The radius of gyration of a polymer chain immersed in a low molecular weight solvent is known to vary monotonically with the solvent quality. Here, we consider the behavior of a chain immersed in a high molecular weight solvent (polymer melt). Unsurprisingly, we find that, as the incompatibility between the chain and the polymer melt is increased, the two limiting conformations of the chain are the ideal random coil (R = aN^1/2) and the dense globule (R = aN^1/3). We show, however, that between these two limits the radius of gyration of the chain presents a hysteretic behavior .
Integrated color pixels in 018-µm complementary metal oxide semiconductor technology (2003)

Following the trend of increased integration in complementary metal oxide semiconductor (CMOS) image sensors, we have explored the potential of implementing light filters by using patterned metal layers placed on top of each pixel's photodetector. To demonstrate wavelength selectivity, we designed and prototyped integrated color pixels in a standard 0.18-microm CMOS technology. Transmittance of several one-dimensional (1D) and two-dimensional (2D) patterned metal layers was measured under various illumination conditions and found to exhibit wavelength selectivity in the visible range. We performed (a) wave optics simulations to predict the spectral responsivity of an uncovered reference pixel and (b) numerical electromagnetic simulations with a 2D finite-difference time-domain method to predict transmittances through 1D patterned metal layers. We found good agreement in both cases. Finally, we used simulations to predict the transmittance for more elaborate designs.