gebhart/patrepeval huggingface dataset:
Selective Synthesis and Reactions of 6-Substituted- 2-β-galactosyl-1,2,4-triazines of Potential Anticancer Activity (2003)

Selective synthesis and reactions of different 6-substituted-2-beta-D-galactosyl-3-thioxo-2,3-dihydro-1,2,4-triazin-5(4H)-ones using the developed amino or aryl protecting group strategy were investigated. Primary human anticancer screening of twelve selected compounds (in vitro) resulted in an active compound against both MCF7 (Breast) and SF-268(CNS) cell lines.
Procedures for Data Analysis in the Information System of Electronic Sales of Vehicles (2021)

Most purchases in pandemic conditions are made remotely using the Internet. Vehicles are very successfully sold at auctions and similar trading platforms. The main differences of online auctions and platforms that allow to sell vehicles are analyzed, their distinctive features in relation to traditional auctions and platforms are determined, the main requirements for building an online application for selling vehicles from the standpoint of buyers and sellers are considered. A conceptual model of a car sales information system is proposed, which saves time for the buyer due to the ability to place an order anytime and anywhere. A goal tree has been developed and analyzed. The software implementation of the specified information system, developed with the help of selected technologies, such as backend - Java and Spring Framework design language, frontend - JavaScript and Vue.js software design language, is analyzed. The technologies of data processing in the information system and precedents to make the necessary query to the database are demonstrated, which is aimed at choosing the right query depending on the selected operation.
Blast-wave analysis of high-pressure coupling shells. Memorandum report (1984)

The interaction between an energetic laser-produced plasma which streams through an ambient plasma exhibits many properties of a blast wave. This document outline the blast-wave theory and finds that it compares favorably to many features found in the NRL laser-plasma HANE simulation experiments. Contrary to expectations of an ideal blast wave, however, the laser-produced coupling fronts develop unusual nonuniformities; mechanisms that may be responsible for this structure are speculated upon.
Neutral glycosphingolipids in hairy cell leukemia (1981)

The neutral glycosphingolipids of hairy cells from a patient with hairy cell leukemia were chemically analyzed by thin-layer and gas-liquid chromatography, mass spectrometry, combined gas chromatography-mass spectrometry, and glycosidase treatment. These cells were found to have compounds containing one to four sugars with the following structures: Glc1 leads to 1Cer Gal beta 1 leads to 4Glc1 leads to 1Cer Gal alpha 1 leads to 4 Gal beta 1 leads to 4Glc1 leads to 1Cer GalNAc beta 1 leads to 3Gal alpha 1 leads to 4Gal beta 1 leads to 4Glc1 leads to 1Cer These compounds belong to the globo series of neutral glycosphingolipids and are similar to those found in human lymphocytes and chronic lymphocytic leukemia cells. They differ from the neutral glycosphingolipids found in human neutrophils and chronic myelogenous leukemia cells which are of the lactoneo and gala type. Neutral glycosphingolipids may be useful in classifying leukemias of uncertain origin.
Neurotrophin-3 and trkC in muscle are non-essential for the development of mouse muscle spindles (1998)

Neurotrophin-3 (NT3) or TrkC null mutant mice were examined for the presence of muscle spindles. Muscles of mastication, but not limbs, contained spindles in newborn and adolescent mutants. The intramuscular distribution and morphological properties of spindles in mutant masticatory muscles were indistinguishable from those of wild-type spindles. Intrafusal fibers of NT3- or trkC-deficient spindles-expressed the slow-tonic isoform of myosin heavy chains, characteristic of wild-type spindles. Sensory nerve endings were observed in spindles of mutants by electron microscopy. Thus, NT3 or trkC, which is expressed in wild-type spindles, may serve functions other than those related to spindle assembly. Presumably, proprioceptive neurons innervating jaw muscles are dependent on factors other than NT3 for survival and maintenance.
Management and Outcomes of Tibial Eminence Fractures in the Pediatric Population: A Systematic Review (2023)

ORIF showed superior clinical outcomes (Tegner (<i>p</i> < 0.05) and Lysholm (<i>p</i> < 0.001) scores) relative to ARIF and a lower incidence of arthrofibrosis (<i>p</i> < 0.05) and implant removal (<i>p</i> < 0.01). The Tegner, IKDC, and Lysholm scores showed statistically significant superior results following arthroscopic sutures compared to arthroscopic screws (<i>p</i> < 0.001). The incidence of arthrofibrosis was higher after arthroscopic sutures (<i>p</i> < 0.05), the implant removal was higher after screw fixation (<i>p</i> < 0.001) Conclusions: Better clinical results with low complication rates were achieved with ORIF surgery rather than ARIF; arthroscopic suture fixation resulted in higher clinical results compared to arthroscopic screw fixation and reduced the incidence of postoperative complications.
Structure and Functions of the Cell Envelope of Gram-Negative Bacteria (1988)

The surface of gram-negative bacteria contains structures that prevent the entry of noxious compounds into the cell and that help the cell evade recognition by host elements such as antibodies and complement while allowing the bacteria to obtain nutrients from the environment and to attach to structures of the host cell. This review discusses the role of outer-membrane components such as lipopolysaccharides and porin, as well as appendages such as capsules and fimbriae in such functions.
Sondas lisimétricas de succión cini herramientas edáficas claves en métodos dubámicos de control y seguimiento del sistema Suelo-Planta-Agua (2010)

Tesis doctoral inedita. Universidad Autonoma de Madrid, Facultad de Ciencias. Fecha de lectura: 11-06-2010
Comparative analysis of discriminant wavelet packet features and raw image features for classification of meningioma subtypes (2007)

The idea of multiresolution analysis has been around for over two decades now. In this paper, we explore a multiresolution analysis based technique for histopathological image classification and compare it with raw image analysis. The principle idea for the former is to derive an optimal wavelet representation, called Adaptive Discriminant Wavelet Packet Transform (ADWPT), of the images in order to achieve the largest discrimination power. Our results show that the textural features combined with ADWPT yield a significant improvement in classification accuracy.
Transcriptional activation of histone H4 by C/EBPβ during the mitotic clonal expansion of 3T3-L1 adipocyte differentiation (2011)

CCAAT enhancer binding protein β (C/EBPβ) is required for both mitotic clonal expansion (MCE) and terminal differentiation during the 3T3-L1 adipocyte differentiation program. Whereas the mechanism of C/EBPβ during terminal differentiation is well understood, the mechanism of C/EBPβ in MCE is not. We provide evidence that histone H4, the most conserved cell cycle-related histone, the change of which is strictly correlated with DNA content change during the cell cycle, is transcriptionally activated by C/EBPβ during MCE. Expression of histone H4 is increased at 16 h after induction when 3T3-L1 preadipocytes synchronously reenter S phase, which is correlated with the sequential phosphorylation and activation of C/EBPβ, and expression was partially suppressed when A-C/EBP (dominant negative for C/EBP protein) was overexpressed. One C/EBP-binding site was identified in one of the histone H4 gene promoters (hist4h4), confirmed by both electrophoretic mobility shift assay and chromatin immunoprecipitation assay. C/EBP-binding sites were also found in 9 of 11 other histone H4 promoters, which can also be transactivated by C/EBPβ. Knockdown of C/EBPβ by stealth small interfering RNA partially decreased H4 gene expression and arrested cells in G1 phase as indicated by bromodeoxyuridine incorporation and fluorescence-activated cell sorting analysis of DNA content. This study provides new insights into why C/EBPβ is required for MCE during 3T3-L1 adipocyte differentiation and why C/EBPβ plays important roles in the proliferation of other cell types.
Development of Level Sensors Based on Fiber Bragg Grating for Railway Track Differential Settlement Measurement (2016)

This paper describes the development of a liquid level sensor based on a fiber Bragg grating (FBG) written in 80-μm diameter optical fiber for railway track differential settlement measurement. The FBG embedded in the sensor is affixed to a float installed inside the liquid-filled sensor body, which measures the upthrust force induced by the float in response to the variations of liquid level. The level measurement and the temperature operation range of the sensor are 0-22 mm and -30°C to 80°C, respectively. Experimental results show that the sensitivity of the sensor is 0.107 nm/mm, which matches well with the designed value.
Endoscopic Injections of Teflon to Treat Urinary Incontinence in Women (1984)

No AccessJournal of UrologyUrodynamics, Physiology and Embryology1 Jul 1984Endoscopic Injections of Teflon to Treat Urinary Incontinence in Women C.C. Schulman, J. Simon, E. Wespes, and F. Germeau C.C. SchulmanC.C. Schulman More articles by this author , J. SimonJ. Simon More articles by this author , E. WespesE. Wespes More articles by this author , and F. GermeauF. Germeau More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49550-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Endoscopic Injections of Teflon to Treat Urinary Incontinence in Women." The Journal of Urology, 132(1), p. 200 © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 132Issue 1July 1984Page: 200 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.MetricsAuthor Information C.C. Schulman More articles by this author J. Simon More articles by this author E. Wespes More articles by this author F. Germeau More articles by this author Expand All Advertisement PDF downloadLoading ...
Intrauterine intravascular transfusions in fetal erythroblastosis: The influence of net transfusion volume on fetal survival (1993)

The intravascular volume load that an anemic fetus can tolerate was studied retrospectively in 124 consecutive intravascular transfusions in 35 erythroblastic fetuses. The tolerated volume load correlated well to the estimated fetal weight. Transfusion volume loads above 20 ml/kg of the estimated fetal weight resulted in a lower fetal survival. We recommend an upper transfusion limit at 20 ml/kg corresponding to approximately 20% of the feto-placental blood volume.
Energy-Optimized Elastic Application Distribution for Automotive Systems in Hybrid Cloud Architectures (2020)

The increase of resource-intensive applications in modern vehicles used for streaming, gaming or autonomous driving results in rising energy-consumption of its advanced computing and connectivity hardware. Especially in electric vehicles, this leads to much higher hardware costs and a decreased vehicle range. Modern premium cars use distributed heterogeneous hardware and mostly communicate via APIs to large cloud backends. Current approaches to reduce on-board energy consumption offload applications partly and make use of limited network connectivity assumptions to their backends. In this paper, we propose a hybrid electric and electronic architecture that manages vehicle hardware by using cloud computing frameworks. Our hybrid cloud architecture is a connection of the local vehicle cloud and a large data centre community cloud. We propose an online optimization algorithm that shifts applications from on-board ECUs to data centre servers and vice-versa. The optimization algorithm minimizes the local energy-consumption while satisfying predicatively dynamic constraints like data rate limitations, application policies and resource limitations. Our approach outperforms the non-predictive approach in average by 16%, in the best case by 21% and in the worst case both behave equally well.
Die Kanalkapazität als Grenze für die Digitalsignalübertragung (1985)

Le calcul de la capacite du canal de Shannon est considere dans des conditions variees telles que: limitation puissance de pente, puissance moyenne du signal transmis, frequence dependante et independante du canal; bruit blanc et colore. Discussion de point de vue de la transmission numerique
Predicted crystal energy landscapes of porous organic cages (2014)

Computational methods predict the crystal packing of porous organic cage molecules, allowing crystal structure and porosity to be predicted starting from the chemical diagram alone.
Biodegradable Nanoparticles Meet the Bronchial Airway Barrier: How Surface Properties Affect Their Interaction with Mucus and Epithelial Cells (2011)

Despite the wide interest raised by lung administration of nanoparticles (NPs) for the treatment of various diseases, little information is available on their effect toward the airway epithelial barrier function. In this study, the potential damage of the pulmonary epithelium upon exposure to poly(lactide-co-glycolide) (PLGA) NPs has been assessed in vitro using a Calu-3-based model of the bronchial epithelial barrier. Positively and negatively charged as well as neutral PLGA NPs were obtained by coating their surface with chitosan (CS), poloxamer (PF68), or poly(vinyl alcohol) (PVA). The role of NP surface chemistry and charge on the epithelial resistance and mucus turnover, using MUC5AC as a marker, was investigated. The interaction with mucin reduced the penetration of CS- and PVA-coated NPs, while the hydrophilic PF68-coated NPs diffused across the mucus barrier leading to a higher intracellular accumulation. Only CS-coated NPs caused a transient but reversible decrease of the trans-epithelial electrical resistance (TEER). None of the NP formulations increased MUC5AC mRNA expression or the protein levels. These in vitro results highlight the safety of PLGA NPs toward the integrity and function of the bronchial airway barrier and demonstrate the crucial role of NP surface properties to achieve a controlled and sustained delivery of drugs via the pulmonary route.
Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome (2023)

The human gut microbiome contains the largest number of bacteria in the body and has the potential to greatly influence metabolism, not only locally but also systemically. There is an established link between a healthy, balanced, and diverse microbiome and overall health. When the gut microbiome becomes unbalanced (dysbiosis) through dietary changes, medication use, lifestyle choices, environmental factors, and ageing, this has a profound effect on our health and is linked to many diseases, including lifestyle diseases, metabolic diseases, inflammatory diseases, and neurological diseases. While this link in humans is largely an association of dysbiosis with disease, in animal models, a causative link can be demonstrated. The link between the gut and the brain is particularly important in maintaining brain health, with a strong association between dysbiosis in the gut and neurodegenerative and neurodevelopmental diseases. This link suggests not only that the gut microbiota composition can be used to make an early diagnosis of neurodegenerative and neurodevelopmental diseases but also that modifying the gut microbiome to influence the microbiome-gut-brain axis might present a therapeutic target for diseases that have proved intractable, with the aim of altering the trajectory of neurodegenerative and neurodevelopmental diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, autism spectrum disorder, and attention-deficit hyperactivity disorder, among others. There is also a microbiome-gut-brain link to other potentially reversible neurological diseases, such as migraine, post-operative cognitive dysfunction, and long COVID, which might be considered models of therapy for neurodegenerative disease. The role of traditional methods in altering the microbiome, as well as newer, more novel treatments such as faecal microbiome transplants and photobiomodulation, are discussed.
Features and Challenges in Runner's Dystonia (P07.199) (2013)

OBJECTIVE: To review characteristics of patients with runner's dystonia (RD).
Making of Safer Automobiles and Intelligent Highways: A Human-Centered Approach (2008)

The United Nation’s World Health Organization estimates that over 3,400 people die and about 100,000 are seriously injured every day on the roads worldwide. A disproportionate number of these accidents occur in Asian countries with rapidly growing economies. In this presentation, we discuss research studies directed towards making road travel safer and more efficient. We will discuss multidisciplinary research activities focused on the design and evaluation of new types of “passive” and “active” safety systems. We will introduce “Human-Centered” approaches which incorporate driver behavior and ethnography surrounding the task of driving in the design of intelligent driver assistance systems. Novel instrumented vehicles are used for conducting experiments, where the rich contextual information about vehicle dynamics, surround and driver state are captured for careful, detailed ethnographic studies, as well as realistic data for developing algorithms to analyze multi sensory signals for active safety. In this presentation, we will provide a systems-oriented framework for developing multimodal sensing approaches, inferencing algorithms and human-vehicle interfaces for safer automobiles. We will consider three main components of the system, driver, vehicle, and vehicle surround. We will discuss various issues and ideas for developing models for these main components as well as activities associated with the complex task of safe driving. The presentation will include discussion of novel sensory systems and algorithms for capturing not only the dynamic surround information of the vehicle but also the state, intent and activity patterns of drivers. We will also introduce a new type of visual display called “dynamic active display”. Illustrative safety systems for smart airbag deployment, collision avoidance, automatic lane keeping, incident detection and congestion mitigation will be presented. We will also discuss emerging trends in vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communication based safety systems.
Parallel Implementation and Optimization of Regional Ocean Modeling System (ROMS) Based on Sunway SW26010 Many-Core Processor (2019)

Nowadays, the ocean numerical models are gradually developing towards multi-physical process and high resolution, with the increment of measured ocean data and more in-depth research in ocean field. Therefore, general computing capability is no longer able to meet these models’ needs. It is necessary to utilize more powerful hardware and parallel software to process the ocean numerical model programs. China has made great process in the research and development of homegrown high performance processors, and sunway sw26010 many-core processor is the most outstanding representative. This paper focuses the lag of the ocean numerical model software matched with homegrown processors, and makes parallel implementation and optimization to regional ocean modeling system (ROMS) based on sunway sw26010 many-core processor for the first time. Furthermore, three kinds of programming methods are utilized in this paper, including OpenACC*, athread with fortran and athread with C. The comparison among these programming methods has been made, from programming method, workload and execution efficiency, which has a practical guiding significance for the programmers that use sunway sw26010 many-core processors. The evaluation measures the execution times and speedups of model kernel and total ROMS with different optimizations, input datasets and numbers of computing processing elements (CPEs). The result shows that, to compare with original ROMS, the speedup of optimized hotspot program can be up to <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$3.69\times$ </tex-math></inline-formula> .
STUDY OF THE INTER-BAND TRANSITION OF THE GaAs SINGLE-CRYSTAL FILM ON SrTiO3 SUBSTRATE BY MBE (1999)

This paper reports the molecular beam epitaxy growth of the GaAs single crystal film on the perovskite oxide SrTiO3(001) substrate. The photo modulated reflectance spectroscopy and the photoluminescence measurement show that the energy band gap
ChemInform Abstract: Potential Hypolipidemic Agents. Part 5. Synthesis and Biological Activity of New Ethyl 4‐(2‐Oxoazetidin‐4‐yl)phenoxyalkanoates. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Characterization of Asynchronous Templates for Integration into Clocked CAD Flows (2009)

Asynchronous circuit design can result in substantial benefits of reduced power, improved performance, and high modularity. However,asynchronous design styles are largely incompatible with clocked CAD,which has prevented wide-scale adoption. The key incompatibility istiming. Thus most commercial work relies on custom CAD or untimeddelay-insensitive design methodologies. This paper proposes a newmethodology, based on formal verification and relative timing, tocreate and prove correct necessary constraints to support asynchronousdesign with traditional clocked CAD. These constraints support timingdriving synthesis, place and route, and behavior and timing validationof fully asynchronous designs using traditional clocked CAD flows.This flow is demonstrated through a simple example pipeline in IBM's 65 nm process showing the ability to retarget the design for improved power and performance.
Detektion von Anomalien zur Qualitätssicherung basierend auf Sequence-to-Sequence LSTM Netzen (2019)

Zusammenfassung Unvorhersehbare Prozessereignisse und Anomalien sind Treiber erhöhter Ineffizienzen in Form von schwankender Produktqualität. In diesem Beitrag wird ein datengetriebener Ansatz zur Qualitätsoptimierung vorgestellt, auf dessen Basis Anomalien charakterisiert werden, die zur Entwurfszeit des Systems nicht bekannt waren. Es wird eine Netzarchitektur in Form eines Sequence-to-Sequence Netzes mit Long Short-Term Memory (LSTM) Zellen vorgestellt. Dadurch kann vorhergesagt werden, welche Anpassung am Stellgrößenverhalten vorgenommen werden muss, um erwartete Anomalien zu kompensieren. Dadurch wird das Qualitätsergebnis langfristig in der Toleranz gehalten. Der Ansatz wird prototypisch anhand von zwei Prozessketten der diskreten Fertigung umgesetzt und evaluiert.
Selective G-quadruplex stabilizers: Schiff-base metal complexes with anticancer activity (2014)

Molecular dynamics simulations and quantum mechanics/molecular mechanics calculations provided a mechanism for G-quadruplex binding of three transition metal complexes.
An in Situ Approach to Nickel-Catalyzed Cycloaddition of Alkynes and 3-Azetidinones (2015)

An efficient and convenient procedure that generates the active Ni(0) catalyst in situ from cheap, air stable Ni(II) precursors is developed for the [4 + 2]-cycloaddition of alkynes and 3-azetidinones. The reaction affords useful 3-dehydropiperidinones in comparable yields to the reported Ni(0) procedure. Additionally, the cycloaddition with 3-oxetanone afforded the 3-dehydropyranone product. Chiral 2-substituted azetidinones were also tolerated to form substituted dehydropiperidinones in high yield and enantiomeric excess.