gebhart/patrepeval huggingface dataset:
Influence of Adipose Tissue Distribution, Sarcopenia, and Nutritional Status on Clinical Outcomes After CD19 CAR T-cell Therapy (2023)

Although CD19-directed chimeric antigen receptor T-cell therapy (CD19.CAR-T) has proven clinical efficacy for multiple refractory B-cell malignancies, over 50% of patients ultimately relapse. Recent evidence has underlined the critical role of the host in determining treatment responses. In this retrospective observational study of 106 patients with relapsed/refractory large B-cell lymphoma receiving standard-of-care CD19.CAR-T, we analyzed the impact of immunometabolic host features and detailed body composition measurements on post-CAR T clinical outcomes. We extracted muscle and adipose tissue distributions from prelymphodepletion CT images and assessed laboratory-based immuno-nutritional scores. Early responders displayed increased total abdominal adipose tissue deposits (TAT: 336 mm3 vs. 266 mm3, P = 0.008) and favorable immuno-nutritional scores compared to nonresponding patients. On univariate Cox regression analysis, visceral fat distribution, sarcopenia, and nutritional indices significantly impacted both progression-free (PFS) and overall survival (OS). Patients with a low skeletal muscle index (SMI; e.g.<34.5), a sarcopenia indicator, exhibited poor clinical outcomes (mOS 3.0 months vs. 17.6 months, log-rank P = 0.0026). Prognostically adverse immuno-nutritional scores were linked to inferior survival [low PNI: HROS, 6.31; 95% confidence interval (CI), 3.35-11.90; P < 0.001]. In a multivariable analysis adjusting for baseline Eastern Cooperative Oncology Group performance status, C-reactive protein, and lactate dehydrogenase, increased TAT was independently associated with improved clinical outcomes (adjusted HROS, 0.27; 95% CI, 0.08-0.90; P = 0.03). We noted particularly favorable treatment outcomes in patients with both increased abdominal fat and muscle mass (TAThigh/SMIhigh: 1-year PFS 50%, 1-year OS 83%). These real-world data provide evidence for a role of body composition and immuno-nutritional status in the context of CD19.CAR-T and suggest that the obesity paradox may extend to modern T cell-based immunotherapies. See related Spotlight by Nawas and Scordo, p. 704.
A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis (2010)

Our analysis uncovered a network of transcription factors that potentially dysregulate several genes in MS or one or more of its disease subtypes. The most significant transcription factor motifs were for the Early Growth Response EGR/KROX family, ATF2, YY1 (Yin and Yang 1), E2F-1/DP-1 and E2F-4/DP-2 heterodimers, SOX5, and CREB and ATF families. These transcription factors are involved in early T-lymphocyte specification and commitment as well as in oligodendrocyte dedifferentiation and development, both pathways that have significant biological plausibility in MS causation.
The Distribution of Internal Derangement in Patients with Temporomandibular Joint Dysfunction—Prevalence, Diagnosis, and Treatments (1992)

This study consisted of 355 patients referred to a surgical practice complaining of facial pain, temporomandibular joint (TMJ) sounds, and limited jaw opening. In 247 patients, 360 TMJs were evaluated by arthrography. While 72.2% of them had internal derangement, the remaining 27.8% had normal arthrograms (NID). Among the patients with internal derangement, meniscal displacement with reduction (MDR) was the largest group (47.3%), followed by meniscal displacement without reduction (MD) (32.3%), meniscal displacement without reduction associated with perforation (MDP) (15.4%), and perforation with normal disk position (P) (5.0%). The NID, MDR, and MD groups showed similar age distributions. The MDP and P groups showed a significantly older mean age. Gender distribution was biased toward females (82.0%). Of the total number of joints, 183 (50.8%) had a history of trauma, 69.9% of which had an internal derangement. In terms of treatment, 100% of the NID group was treated by splint therapy. The MDR group was mostly treated by partial meniscectomy (49.6%) and splint therapy (41.5%). The MD group was mostly treated by total meniscectomy (53.6%) followed by splint therapy (32.1%). The MDP or P groups mostly underwent total meniscectomy (72.5% and 61.5%, respectively).
Improving the intrinsic thermal stability of the MAPbI3 perovskite by incorporating cesium 5-aminovaleric acetate (2018)

Cesium 5-aminovaleric acetate (NH<sub>2</sub>C<sub>4</sub>H<sub>8</sub>COOCs) was used to improve the intrinsic thermal stability of the methylammonium lead triiodide (MAPbI<sub>3</sub>) perovskite. The corresponding carbon-based perovskite solar cells without encapsulation showed favourable stability at 100 °C for 500 h.
Some Features of the Action of Purine Nucleosides on the Lipolytic Activity of Adipose Tissue (1974)

Conference Article| June 01 1974 Some Features of the Action of Purine Nucleosides on the Lipolytic Activity of Adipose Tissue MARIE-LOUISE RABOUHANS; MARIE-LOUISE RABOUHANS 1Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Caerns. LL57 2UW, U.K. Search for other works by this author on: This Site PubMed Google Scholar DERMOT M. F. COOPER; DERMOT M. F. COOPER 1Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Caerns. LL57 2UW, U.K. Search for other works by this author on: This Site PubMed Google Scholar J. ISLWYN DAVIES J. ISLWYN DAVIES 1Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Caerns. LL57 2UW, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1974 Biochemical Society1974 Biochem Soc Trans (1974) 2 (3): 395–398. https://doi.org/10.1042/bst0020395 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation MARIE-LOUISE RABOUHANS, DERMOT M. F. COOPER, J. ISLWYN DAVIES; Some Features of the Action of Purine Nucleosides on the Lipolytic Activity of Adipose Tissue. Biochem Soc Trans 1 June 1974; 2 (3): 395–398. doi: https://doi.org/10.1042/bst0020395 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1974 Biochemical Society1974 Article PDF first page preview Close Modal You do not currently have access to this content.
Pharmacotherapy for Body Dysmorphic Disorder: Treatment Received and Illness Severity (2006)

A high proportion of individuals with BDD receive pharmacotherapy, primarily SRIs, although most SRI trials appear inadequate for BDD. SRI treatment that was considered adequate was associated with greater improvement in BDD and less severe BDD symptoms.
A Comprehensive, Automatically Updated Fungal ITS Sequence Dataset for Reference-Based Chimera Control in Environmental Sequencing Efforts (2015)

The nuclear ribosomal internal transcribed spacer (ITS) region is the most commonly chosen genetic marker for the molecular identification of fungi in environmental sequencing and molecular ecology studies. Several analytical issues complicate such efforts, one of which is the formation of chimeric-artificially joined-DNA sequences during PCR amplification or sequence assembly. Several software tools are currently available for chimera detection, but rely to various degrees on the presence of a chimera-free reference dataset for optimal performance. However, no such dataset is available for use with the fungal ITS region. This study introduces a comprehensive, automatically updated reference dataset for fungal ITS sequences based on the UNITE database for the molecular identification of fungi. This dataset supports chimera detection throughout the fungal kingdom and for full-length ITS sequences as well as partial (ITS1 or ITS2 only) datasets. The performance of the dataset on a large set of artificial chimeras was above 99.5%, and we subsequently used the dataset to remove nearly 1,000 compromised fungal ITS sequences from public circulation. The dataset is available at http://unite.ut.ee/repository.php and is subject to web-based third-party curation.
Endothelins in Pulmonary Development (1998)

Endothelins (ETs), first discovered as potent vasoconstrictors, are a family of polypeptides with a wide range of activities in the airvays and pulmonary vascular system. Synthesized by respiratory epithelium and by pulmonary vascular endothelium, ETs, as a potent bronchoconstrictors and mitogens, may play a role in the pathogenesis of pulmonary hypertension and bronchial asthma. ETs are a part of a complex homeostatic mechanism in mature airways however, a critical biological role of ETs have been implicated of modulating the development of the lung and vasculature, of Hirschsprung’s disease, of asthma and potentially pulmonary hypertension. Lack of ET-1, ETA receptor or endothelin-converting enzyme-1 (ECE-1), as result of complete knockout of the ET-1, ETA receptor or ECE-1 genes, induces abnormalities of the pharyngeal-arch-derived craniofacial tissues and death by respiratory failure at birth. In humans and mice normal development of epidermal melanocytes and enteric ganglion neurons are affected by ET-3 and ETB receptor genes. Mutations in the ETB receptor gene mapped to chromosome 13 resulted in development of Hirschsprung disease in humans. Taken together, compelling evidence suggests that ET-1
Laser Metrology Heterodyne Phase-Locked Loop (2009)

A method reduces sensitivity to noise in a signal from a laser heterodyne interferometer. The phase-locked loop (PLL) removes glitches that occur in a zero-crossing detector s output [that can happen if the signal-to-noise ratio (SNR) of the heterodyne signal is low] by the use of an internal oscillator that produces a square-wave signal at a frequency that is inherently close to the heterodyne frequency. It also contains phase-locking circuits that lock the phase of the oscillator to the output of the zero-crossing detector. Because the PLL output is an oscillator signal, it is glitch-free. This enables the ability to make accurate phase measurements in spite of low SNR, creates an immunity to phase error caused by shifts in the heterodyne frequency (i.e. if the target moves causing Doppler shift), and maintains a valid phase even when the signal drops out for brief periods of time, such as when the laser is blocked by a stray object.
Meiotic, cryptic, and stable unannotated transcripts: Noncoding RNAs add to the epigenetic tool box controlling meiotic development (2011)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Characterization of GalR1, GalR2, and GalR3 immunoreactivity in catecholaminergic nuclei of the mouse brain (2004)

The distribution of immunoreactivity for the three identified neuropeptide galanin receptors, GalR1, GalR2, and GalR3, was determined in areas of the mouse brain involved in drug addiction, including the ventral tegmental area (VTA), substantia nigra (SN), nucleus accumbens (NA), and locus coeruleus (LC). All three galanin receptors are found in the VTA, SN, NA, and LC; however, GalR1 protein is most highly represented in the VTA, NA, and SN, suggesting that GalR1 may play a predominant role in galanin-mediated regulation of dopamine neurotransmission. GalR1 and GalR3 protein levels are high in the LC, suggesting that these isoforms may be important for galanin-mediated regulation of noradrenergic transmission during opiate withdrawal. Although the distribution of GalR1, GalR2, and GalR3 largely recapitulates the pattern of galanin binding throughout the brain, some discrepancies exist, suggesting that another galanin receptor(s) may be present in some brain areas. Overall, GalR1, GalR2, and GalR3 are distributed widely throughout the brain, correlate with widespread galanin binding, and colocalize with tyrosine hydroxylase in catecholaminergic brain areas.
Infection with Mycobacterium malmoense in Sweden: Report of 221 Cases (1994)

Mycobacterium malmoense was first described in 1977 and today is second only to the Mycobacterium avium complex as a cause of atypical mycobacterial infection in Sweden. We retrospectively studied the records of 221 patients from whom M. malmoense was isolated during 1968-1989. M. malmoense was recovered from the respiratory tract of 171 patients (170 adults and one child) and from cervical lymph nodes of 36 patients (35 children and one adult). In addition, the organism was isolated from the urine of six patients, one of whom had disseminated disease and two of whom had abscesses caused by M. malmoense. A majority of the patients with pulmonary infection as well as the patient with disseminated disease had other underlying diseases.
Three-dimensional contrast-ultrasound dispersion imaging for prostate cancer localization, a feasibility study (2014)

Prostate cancer (PCa) is the type of cancer with the highest incidence in men in Western countries. To date, reliable tools for PCa localization are lacking. Recently, contrast-ultrasound dispersion imaging (CUDI) by spatiotemporal analysis performed on transrectal dynamic contrast-enhanced ultrasound (DCE-US) has been proposed as a promising option for PCa localization. This technique evaluates the spatial similarity between indicator dilution curves in a ring-shaped kernel and its center pixel. Until now, CUDI has been performed in 2D only. Hence, each imaged plane requires a separate bolus injection of contrast agent, motion compensation is limited, and out-of-plane contrast flow cannot be observed. 3D DCE-US can potentially solve the aforementioned issues, permitting the analysis of the entire prostate with a single bolus injection. In this work, we implemented a full 4D spatiotemporal similarity analysis. Its feasibility to localize PCa was evaluated in 2 patients by qualitatively comparing similarity maps obtained by 3D CUDI with those obtained by 2D CUDI in the corresponding planes and with histopathologic results from 12-core systematic biopsies. All results showed good agreement, confirming the feasibility of 3D CUDI for PCa localization and encouraging extension of the study to a larger dataset. Additionally, the characteristics - and in particular the spatial and temporal resolution - of 3D DCE-US were analyzed with respect to the requirements for CUDI. Both the spatial and temporal resolution were considered to be sufficient for CUDI.
Upper extremity skeletal muscle mass: Potential of measurement with single frequency bioimpedance analysis (1998)

This study examined the potential of single frequency (50 kHz) BIA for estimation of upper extremity skeletal muscle (SM) mass. Subjects (n = 50) were weight stable adults varying in age (X +/- SD, 51.6 +/- 17 yr) and body mass index (27.2 +/- 5.9 kg/m2). Determinants of arm to arm impedance index (length L; L2/Z) were examined using multiple regression analysis. A good correlation was observed between L2/Z and arm SM estimated by dual-energy X-ray absorptiometry (r = 0.88, p < 0.001). Additional significant model covariates were arm fat mass (p < 0.05), bone mass (p < 0.01), and age (p < 0.001). These findings suggest that upper extremity SM may be rapidly and easily quantified using a simple and inexpensive BIA system combined with appropriate age-adjusted impedance prediction equations.
Mn（III）-四芳基卟啉与高碘酸四丁基铵催化羧酸的氧化脱羧：金属、取代基和轴向阴离子配体的影响 (2007)

锰四芳基卟啉与高碘酸四丁基铵（n-Bu4NIO4）和咪唑（ImH）组合，为羧酸氧化脱羧提供了一个有效的催化剂体系．中位含有吸电子基团和／或大体积芳基的中位一四芳基卟啉使金属卟啉的活性降低．眯唑的存在和金属中心的选择对金属卟啉的催化性能起关键性作用，催化体系中的反离子也有重要影响．Mn（TPP）CN／n-Bu4NIO4／ImH体系的催化活性最好．二苯基乙酸的氧化脱羧可能涉及高价的含氧锰物种与反应物间的相互作用，提出了可能的反应机理．
Dielectric response induced by intersubband transitions in quantum wells: Transmission ellipsometry studies at Brewster angle (1994)

The potential of infrared transmission spectroscopic ellipsometry is demonstrated for the case of intersubband transitions between the first and second upper-lying conduction-band states in a quantum well. Using the substrate-ambient interface as a Brewster polarizer, multiple reflections in the sample are modeled to occur only at a bare substrate-ambient interface. The ellipsometrically measured polarization ratio is related to the transfer-matrix elements of the overlayer by treating the latter as an effective medium uniaxial layer, grown on top of an isotropic substrate. The above approach is applied for a 60 period n-GaAs/Al0.3Ga0.7As (88 Å/130 Å) quantum-well stack, grown on a semi-insulating GaAs substrate. The experimentally extracted dielectric response of the overlayer to the propagating extraordinary beam is compared to the spectrum, calculated using a Lorentzian oscillator, centered at 1045 cm−1 with broadening of 100 cm−1, as expected from the engineered potential.
Sterility testing of cell therapy products: parallel comparison of automated methods with a CFR‐compliant method (2006)

Compared to the CFR method, both BacT/ALERT and Bactec are more sensitive, faster in time to detection, less prone to false-positive results, and less labor-intensive. Both of these automated systems are suitable for sterility testing of cell therapy products after site-specific validation has been performed.
MSURU: Large Scale E-commerce Image Classification with Weakly Supervised Search Data (2019)

In this paper we present a deployed image recognition system used in a large scale commerce search engine, which we call MSURU. It is designed to process product images uploaded daily to Facebook Marketplace. Social commerce is a growing area within Facebook and understanding visual representations of product content is important for search and recommendation applications on Marketplace. In this paper, we present techniques we used to develop efficient large-scale image classifiers using weakly supervised search log data. We perform extensive evaluation of presented techniques, explain practical experience of developing large-scale classification systems and discuss challenges we faced. Our system, MSURU out-performed current state of the art system developed at Facebook [23] by 16% in e-commerce domain. MSURU is deployed to production with significant improvements in search success rate and active interactions on Facebook Marketplace.
Wave-equation Rayleigh wave inversion using fundamental and higher modes (2018)

Recorded surface waves often provide reasonable estimates of the Shear wave velocity in the near surface. However, these estimates tend to be low in resolution considering that they depend on dispersion nature of the fundamental mode of surface waves. We present a surface-wave inversion method that inverts for the S-wave velocity from the fundamental- and higher-modes of Rayleigh waves. The proposed method aims to maximize the similarity of the phase velocity (f−v) spectrum of the surface waves with all-Rayleigh wave modes (if they exist) in the inversion. The f−v spectrum is calculated using the linear Radon transform and by using a local similarity-based objective function, we do not need to pick velocities in the spectrum plots. Thus, the best match between the predicted and observed data f−v spectrum provides the optimal estimation of S-wave velocity. We derive the gradient of the proposed objective function using the adjoint-state method and solve the optimization problem using the LBFGS method. Our method can invert for lateral velocity variations, include all-mode dispersions, and mitigate the local minimum problem in full waveform inversion with a reasonable computation cost. Results with synthetic and field data illustrate the benefits and limitations of this method. Presentation Date: Tuesday, October 16, 2018 Start Time: 8:30:00 AM Location: 204A (Anaheim Convention Center) Presentation Type: Oral
Economic crisis, austerity and unmet healthcare needs: the case of Greece (2016)

The adverse economic environment has significantly affected unmet health needs. Therefore health policy actions and social policy measures are essential in order to mitigate the negative impact on access to healthcare services and health status.
6-Alkylpenicillins and 7-alkylcephalosporins (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT6-Alkylpenicillins and 7-alkylcephalosporinsEkkehard H. W. Bohme, Harold E. Applegate, Jacqueline B. Ewing, Philip T. Funke, Mohindar S. Puar, and Joseph E. DolfiniCite this: J. Org. Chem. 1973, 38, 2, 230–236Publication Date (Print):January 1, 1973Publication History Published online1 May 2002Published inissue 1 January 1973https://pubs.acs.org/doi/10.1021/jo00942a008https://doi.org/10.1021/jo00942a008research-articleACS PublicationsRequest reuse permissionsArticle Views100Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Obstacle detection for a vehicle using optical flow (2003)

A novel approach to obstacle detection using optical flow without recovering range information has been developed. This method can be used for ground vehicles to navigate through man-made roadways or natural outdoor terrain or for air vehicles to land on known or unknown terrain. A linear relationship, plotted as a line and called a reference flow line, has been found. This reference flow line can be used to detect discrete obstacles above or below the reference terrain. Slopes of surface regions are also computed. The approach is simple, fast, and robust because: (1) the only required information is one component of the optical flow, (2) each image line can be processed in parallel, and (3) the error sources involved are reduced to a minimum. An initial experiment using noisy synthetic data is also included to demonstrate the applicability and robustness of the method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Temperature effects on metal-alumina-nitride-oxide-silicon memory operations (2010)

We present a detailed investigation of temperature effects on the operation of TaN/Al2O3/Si3N4/SiO2/Si (TANOS) memory devices. We show that not only retention but also program and erase operations are affected significantly by temperature. Using a large set of experimental data and simulations on a variety of TANOS stacks, we show that the temperature dependence of TANOS program and erase operations can be explained by accounting for that the alumina dielectric constant increases by 20%–25% over a 125 K temperature range.
Shannon meets Wiener II: On MMSE estimation in successive decoding schemes (2004)

We continue to discuss why MMSE estimation arises in coding schemes that approach the capacity of linear Gaussian channels. Here we consider schemes that involve successive decoding, such as decision-feedback equalization or successive cancellation.
Lathyrus tuberosus L. (2002)

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