gebhart/patrepeval huggingface dataset:
BLE-based Power Efficient WSN for Industrial IoT Train Integrity Monitoring (2022)

Monitoring train integrity is a very important topic for economical, management and safety reasons. Knowing the localization, volume and other parameters is very valuable for most train and large industry companies. Current literature focuses on placing many sensors in a Wireless Sensor Network (WSN) around the train wagons, but do not take battery lifetime into perspective. With the increasing interest in industrial Internet of Things (IoT) applications, the connectivity and battery lifetime are very important parameters. In this paper, the vibrations measured on train wagons are analyzed in order to find the most optimal trigger point to wake up or to put the WSN in a deep sleep mode. This way, a large amount of power can be saved and extend the battery lifetime significantly. Furthermore, several Received Signal Strength Indicator (RSSI) measurements were performed to find the optimal Tx level and antenna topology for communication between different wireless sensor nodes on the train wagon. The proposed measurements show that an inexpensive accelerometer and a prefabricated antenna are perfectly usable in the WSN. RF measurements on the brakes results in an average Package Receive Rate (PRR) of approximately 92 % and an Average Received Power (ARP) of around −83 dBm starting from a Tx level of 4 dBm.
The Implementation of Multi-user 3D-Scene Using EAI (2002)

EAI is the interface to communicate events between VRML and Java Applet. By using EAI, we can implement the interactive user interface in 3D space based on WEB. This Paper introduces how to control VRML objects with Java, and presents a framework to implement Multi-user 3D-Scene on the WEB in detail. Multiple users are allowed to interact within this 3D-Space simultaneously.
Exploiting Multipath Propagation for GMTI in Urban Environments (2006)

This paper evaluates the potential for exploiting multipath propagation for improved radar detection of moving ground targets in dense urban environments. In particular, the radar coverage offered by exploiting non-line-of-sight (NLOS) propagation from an airborne radar platform is considered. A quasi-analytical model for NLOS propagation assuming multiple specular reflections off buildings is derived to evaluate radar coverage as a function of target range, aircraft altitude, building height and separation, and relative target position on a street. A statistical characterization of the urban environment is used to compute probabilities of line-of-sight versus non-line-of-sight propagation and surveillance sweep width. Comparison of sweep width for LOS versus at least one NLOS path indicates that NLOS could offer a significant improvement in coverage rate. In essence, NLOS propagation permits radar surveillance at longer ranges with lower altitude radar platforms. In addition to radar coverage, the Cramer-Rao lower bound (CRLB) for estimation of target position in a specular multipath environment is derived. The CRLB indicates that, in theory, range accuracy improves with multiple paths and that only three paths are required to jointly estimate target range, position within the street, and street width.
Phase I dose-finding study of oral ERK1/2 inhibitor LTT462 in patients (pts) with advanced solid tumors harboring MAPK pathway alterations. (2020)

3640 Background: LTT462 is an investigational small molecule inhibitor of ERK1/2, which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. This first-in-human study was designed to evaluate the safety and tolerability of LTT462 in advanced solid tumors harboring MAPK pathway alterations (NCT02711345). Methods: The dose-escalation part of this Phase I, open-label study, enrolled adult and adolescent pts with advanced solid tumors harboring ≥1 documented MAPK pathway alteration with progressive disease (PD) despite standard therapy, or for whom there is no effective standard treatment. Oral LTT462 was given once daily (QD) at 45–600 mg or twice daily (BID) at 150 mg or 200 mg. Objectives were to determine the maximum tolerated dose (MTD) using a Bayesian hierarchical logistic regression model guided by escalation with overdose control, and characterize safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of LTT462. Results: Sixty-five pts (median age 60 years) including 1 pt aged 15 were enrolled in the dose-escalation; most pts (22%) had 3 prior therapies. Most common primary sites for cancer were in the colon (n = 21; 32%), ovary (n = 9; 14%), and pancreas (n = 7; 11%). All pts discontinued, the majority due to PD (n = 44; 68%). Eleven pts experienced DLTs; 6 pts experienced Grade 3 eye disorder DLTs (4 pts retinopathy, 2 pts chorioretinopathy). Treatment-related adverse events (TRAEs) were reported for 89% of pts, most commonly ( &gt; 30%) diarrhea (n = 25; 38%) and nausea (n = 22; 34%). Grade 3/4 TRAEs were reported in 29% of pts; most common was retinopathy (n = 4; 6%). MTD of LTT462 was 400 mg QD and 150 mg BID. Overall, 8 pts (12%) had stable disease (SD) and 35 pts (54%) had PD. An unconfirmed partial response was reported in a pt with cholangiocarcinoma with BRAF mutation; best change in sum of target lesions per RECIST 1.1 was -33.9%. LTT462 increased plasma peak drug concentration and drug exposure at increasing doses between 45–450 mg QD. Exposure at LTT462 600 mg QD was lower than anticipated, indicating potential saturation of absorption at this dose. LTT462 inhibited ERK1/2 and reduced DUSP6 expression relative to baseline in most pts evaluated. Conclusions: LTT462 is well tolerated. Limited clinical activity was reported with single agent LTT462; best overall response was SD. An ongoing study is investigating LTT462 in combination with the RAF inhibitor, LXH254, in NSCLC and melanoma. Clinical trial information: NCT02711345 .
CHANGES IN MILK, WHEY, AND BLUE CHEESE AS INDUCED BY BENZOYL PEROXIDE1,2 (1974)

Milk proteins were subjected to treatment with various levels of benzoyl peroxide, with and without heating at 60 C for 2 h. Heating had a pronounced effect on whey proteins, but polyacrylamide gel electrophoresis revealed changes in proteins not attributable to heat alone. The effect on proteins was reflected in an increased tendency for the benzoyl peroxide-heat treated cheeses to expel moisture during leakage tests. Use of 17.8 ppm benzoyl peroxide resulted in a markedly whiter cheese than that made using 5.9 ppm and reflectance studies indicated this to be true even when no heat treatment accompanied the benzoyl peroxide. Use of benzoyl peroxide in the bleaching process did not decrease mold development in ripening loaves nor was acid production by lactic cultures diminished. In addition, proteolysis of milk proteins by rennet was not reduced by the presence of benzoyl peroxide.
An Introduction to Chinese Legislation (2004)

The editors of Global Studies invited me to write this piece in order to familiarize the reader with the circumstances in the People’s Republic of China (PRC) that surround the drafting of the Anti-Monopoly Law.
Exposure of von Willebrand Factor on Isolated Hepatocytes Promotes Tethering of Platelets to the Cell Surface (2019)

VWF on isolated Hc causes, in contact with blood, adhesion of platelets, which thereby forms an ideal surface for coagulation. This phenomenon needs to be considered in hepatocyte-based reconstitution therapy and possibly even in other settings of cell transplantation.
Serial Defibrillation Lead Impedance in Patients with Epicardial and Nonthoracotomy Lead Systems (1996)

Significant changes in defibrillation lead impedance occur after implantation of epicardial and nonthoracotomy defibrillation lead systems. These data may serve as a standard for identifying the anticipated maximum change in lead impedance and thus may be useful as a tool for recognizing problems with defibrillation lead integrity.
Refined localization of the melanoma (MLM) gene on chromosome 9p by analysis of allelic deletions. (1994)

Various lines of evidence including linkage analysis, frequent homozygous and heterozygous deletions in melanoma DNAs, and the finding of a patient with multiple primary melanomas who harbours a 5p/9p translocation involving loss of several 9p markers, have indicated that the 9p22-p13 region harbours a gene important for the development of melanoma (MLM). We have used eight short tandem repeat polymorphism (STRP) markers mapping to this region to look for allelic losses in DNA from melanoma biopsies and cell lines. Heterozygous losses were found in 8/14 (57%) fresh melanoma biopsy DNAs with the smallest region of overlap (SRO) being between IFNA and D9S169. In addition, when DNA from 30 melanoma cell lines was studied, four cell lines (13%) were found to be homozygously deleted for various 9p markers. Two of these cell lines define the borders of overlapping homozygous deletions within a 4cM region of 9p21 between IFNA and D9S171. Moreover, a further 14 melanoma cell lines were hemizygous for the IFNA/D9S171/D9S126 region. These data support the hypothesis that the MLM gene acts as a tumour suppressor, and provide a refinement of its localization on 9p.
Topological mapping (2002)

In this paper, we present a novel approach for efficient search of shots by the colors of objects that exist in the wanted shots. The idea is to map the color histogram, which represents the color content, of each object in the shot from the high-dimensional feature space into a point in a low-dimensional distance space. Then, a spatial access method, such as an R-tree, is used to cluster these points based on their distances in the low-dimensional space. Our mapping method, called topological mapping, guarantees no false dismissals in the result of a query. However, the result of a query might contain some false alarms. Hence, two refinement steps are performed to remove these false alarms. Comparative experiments show the superiority in efficiency of the topological mapping method over other methods.
ChemInform Abstract: Haloboration of Alkynes and Related Reactions (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors (2003)

Signal transduction processes activated by Toll-like receptors (TLRs) include the important transcription factor NF-kappaB and 2 MAP kinases, p38 and Jun N-terminal kinase. These signals ultimately give rise to increased expression of a multitude of pro-inflammatory proteins. Receptor-proximal proteins involved in signalling by all TLRs include the adapter MyD88, 3 IRAKs (IRAK-4, IRAK and IRAK-2), Tollip, Traf-6 and TAK-1. Differences between signals generated by TLRs are emerging, with both TLR4 and TLR2 signalling requiring an additional adapter termed MyD88-adapter-like (Mal; also known as TIRAP). MyD88 and Mal both have a homologous Toll/IL-1 receptor (TIR) domain although they differ in their N-termini, with MyD88 possessing a death domain. In addition, structural models reveal marked differences in surface charges which, when taken with surface charge differences between TLR2 and TLR4 TIR domains, may indicate that TLR4 but not TLR2 recruits Mal directly. Another difference is that Mal can become phosphorylated. Future studies on Mal will reveal specificities in signal transduction by different TLRs, which may ultimately provide molecular explanations for specificities in the innate immune response to infection.
Amyloid Precursor Protein and Presenilin1 Interact with the Adaptor GRB2 and Modulate ERK 1,2 Signaling (2007)

The amyloid precursor protein (APP) and the presenilins 1 and 2 are genetically linked to the development of familial Alzheimer disease. APP is a single-pass transmembrane protein and precursor of fibrillar and toxic amyloid-beta peptides, which are considered responsible for Alzheimer disease neurodegeneration. Presenilins are multipass membrane proteins, involved in the enzymatic cleavage of APP and other signaling receptors and transducers. The role of APP and presenilins in Alzheimer disease development seems to be related to the formation of amyloid-beta peptides; however, their physiological function, reciprocal interaction, and molecular mechanisms leading to neurodegeneration are unclear. APP and presenilins are also involved in multiple interactions with intracellular proteins, the significance of which is under investigation. Among the different APP-interacting proteins, we focused our interest on the GRB2 adaptor protein, which connects cell surface receptors to intracellular signaling pathways. In this study we provide evidence by co-immunoprecipitation experiments, confocal and electron microscopy, and by fluorescence resonance energy transfer experiments that both APP and presenilin1 interact with GRB2 in vesicular structures at the centrosome of the cell. The final target for these interactions is ERK1,2, which is activated in mitotic centrosomes in a PS1- and APP-dependent manner. These data suggest that both APP and presenilin1 can be part of a common signaling pathway that regulates ERK1,2 and the cell cycle.
A new delegation-based authentication protocol for use in portable communication systems (2005)

Portable communication systems (PCSs) provide a convenient means of communication; however, many problems arise relating to data security, user privacy, computational load, and communicational efficiency. To provide solutions for these problems, we introduce the concept of delegation into the wireless communication system. This new model makes our scheme an especially valuable improvement to portable communication systems.
Exploiting Prior 2 Dimensional or 3 Dimensional Spatial Information for Diffuse Optical Imaging (2002)

We include x-ray images as priory information into the DOT image reconstruction.. The way of imposing the x-ray constraint is a variant of Tikhonov regularization in which spatial variance is allowed in the value of regularization parameter. The information of the spatial variance is based on the x-ray 3-D image. Simulations show the images’ resolution is improved with x-ray soft constraint.
1397: OUTCOMES AMONG PATIENTS TREATED WITH RENAL REPLACEMENT THERAPY DURING ECMO (2019)

Dado, David; Basel, Anthony; Ainsworth, Craig; Chung, Kevin; Thomas, Sarah; Batchinsky, Andriy; Morrow, Benjamin; Sams, Valerie; Piper, Lydia Author Information
Laser catheter coagulation of normal and scarred ventricular myocardium in dogs (1998)

Nd:YAG laser pulses at 10-20 W and 15-60 s produce homogeneous myocardial lesions of coagulation necrosis of reproducible sizes, in a controllable manner, without unwanted effects on the ventricular walls, in normal and through scarred myocardium of dogs. The laser method is a promising alternative for ablation of ventricular arrhythmias including candidates with ischemic heart disease.
Analysis and simulation of optical response of Au-nanoparticle-fixed beads for optical sensors of microscopic local environment (2011)

In this paper, therefore, the authors experimentally analyze the optical response of AuNP-fixed bead, and propose new types of optical sensors based on the self-consistent electromagnetic theory.
Input-parallel output-series cascading possibilities of single-switch galvanically isolated quasi-Z-source DC-DC converters (2016)

Focus is on a transformer based single-switch galvanically isolated quasi-Z-source converter. Single-switch topologies suit well for low power applications due to low complexity and cost of realization. However, their performance is rather limited, since only one switch should handle all converter power. Input-parallel output-series (IPOS) cascading improves stress of semiconductor devices, reliability, input current ripple, efficiency and DC voltage gain in a wide range of the input voltage, while maintaining the duty cycle of the switches within a reasonable range. The proposed two different approaches for IPOS cascading are analyzed and compared with the reference single-switch topology. Theoretical results are supported with a simulation study using PSIM software including Thermal Module for semiconductor power losses analysis.
Assessment of the relative skin sensitization potency of siloranes and bis‐GMA using the local lymph node assay and QSAR predicted potency (2006)

Abstract Siloranes are silicon and oxirane (epoxy) containing monomers used for new dental composite development. The siloranes 3,4‐epoxycyclohexylethyl‐cyclopolymethylsiloxane (Tet‐Sil) and bis‐3,4‐epoxycyclohexylethyl‐phenyl‐methylsilane (Ph‐Sil) have in common cycloaliphatic epoxy moieties. The epoxy group is of concern in their biocompatibility since most epoxy compounds are known skin sensitizers. The objective of this study was to determine the in vivo skin sensitization potency of the siloranes in the local lymph node assay. A comparison was made with well‐known chemical allergens, bis‐GMA and DNCB. Female mice (CBA/CaJ) were exposed topically (dorsum of both ears) to several doses of acetone:olive oil in the ratio of 4:1 v/v. Doses were defined by a predictive structure‐activity model (QSAR) for contact sensitization. Lymph node cell (LNC) proliferation was measured on the sixth day by incorporation of radioactive thymidine into DNA of lymph node cells. The effective concentration (EC3) that produced a 3‐fold stimulation in LNC proliferation relative to controls was extrapolated from dose‐response curves. DNCB was a strong sensitizer (EC3 = 0.06%). The EC3 values of Ph‐Sil and bis‐GMA were 19% and 45%, respectively, making these weak contact sensitizers. Tet‐Sil did not increase lymph node proliferation when compared with controls. In contrast to Tet‐Sil, the unpolymerized monomers Ph‐Sil and bis‐GMA have the capacity to induce LNC proliferation, characteristic of a T‐cell mediated skin contact sensitization. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006
Approche bioinformatique et fonctionnelle pour la caractérisation de protéines sécrétées chez les Trypanosomatidés : implication dans la biologie et la virulence du parasite (2009)

Les Trypanosomatidés Leishmania spp., Trypanosoma cruzi et Trypanosoma brucei sont responsables de pathologies humaines, dont le cycle de vie alterne entre un insecte vecteur et un hôte vertébré. Ces pathogènes ont développé différentes stratégies pour assurer leur survie chez leurs hôtes. Des facteurs de sécrétion jouent un rôle important dans l'infection et dans la modulation de la réponse immune de l'hôte. Les protéines sécrétées représentent donc des cibles potentielles pour la conception de nouvelles thérapies et/ou de nouveaux vaccins. Nous avons développé une approche basée sur des analyses bioinformatiques afin d'identifier des protéines conservées chez les Trypanosomatidés, impliquées dans la voie de sécrétion classique. Cette méthode nous a permis d'identifier trois nouvelles protéines conservées, sécrétées dans le milieu extracellulaire. L'étude des propriétés biologiques de ces protéines suggère que l'une d'entre elles est impliquée dans un processus favorisant la survie du parasite Leishmania et sa replication à l'intérieur de la cellule hôte. Les études portant sur l'immunogénicité des protéines sécrétées par T. cruzi ont montré que l'une des protéines est très antigénique chez l'homme. L'ensemble de ces résultats démontre l'utilité des analyses bioinformatiques couplées à des tests fonctionnels pour l'identification de nouvelles protéines sécrétées, représentant des facteurs de virulence ou des facteurs antigéniques potentiels des Trypanosomatidés.
Stirling Engine With Radial Flow Heat Exchangers (1993)

Conflict between thermodynamical and structural requirements resolved. In Stirling engine of new cylindrical configuration, regenerator and acceptor and rejector heat exchangers channel flow of working gas in radial direction. Isotherms in regenerator ideally concentric cylinders, and gradient of temperature across regenerator radial rather than axial. Acceptor and rejector heat exchangers located radially inward and outward of regenerator, respectively. Enables substantial increase in power of engine without corresponding increase in diameter of pressure vessel.
Escherichia coli grpE gene codes for heat shock protein B25.3, essential for both lambda DNA replication at all temperatures and host growth at high temperature (1986)

We have identified the grpE gene product as the B25.3 heat shock protein of Escherichia coli on the following evidence: (i) a protein similar in size and isoelectric point to B25.3 was induced after infection of UV-irradiated bacteria by lambda grpE+ transducing phage, (ii) mutant phage lambda grpE40, isolated by its inability to propagate on grpE280 bacteria, failed to induce the synthesis of the B25.3 protein, and (iii) lambda grpE+ revertants, derived from phage grpE40 as able to propagate on grpE280 bacteria, simultaneously recovered the ability to induce synthesis of the B25.3 protein. In addition, we show that E. coli bacteria carrying the grpE280 mutation are temperature sensitive for bacterial growth at 43.5 degrees C. Through transductional analysis and temperature reversion experiments, it was demonstrated that the grpE280 mutation is responsible for both the inability of lambda to replicate at any temperature tested and the lack of colony formation at high temperature. At the nonpermissive temperature the rates of synthesis of DNA and RNA were reduced in grpE280 bacteria.
Condição nutricional e prevalência de anemia em crianças matriculadas em creches beneficentes (2005)

"Objetivo: Avaliar a condição nutricional e a prevalência de anemia em crianças matriculadas em creches beneficentes.Métodos: Este estudo de corte transversal observou 942 crianças em oito creches da Cruzada Pró-Infância em São Paulo – Brasil, com idade de 6 meses a 6 anos, para a avaliação nutricional por antropometria, e 250 crianças, na faixa etária de 6 a 36 meses, para a prevalência de anemia. Utilizados os escore Z do índice de peso para estatura (P/E) para classificar o estado nutricional em desnutrição atual (Z &lt; -2) e obesidade (Z &gt; 2), e o índice estatura para a idade (E/I) para classificar em desnutrição crônica (Z &lt; -2). O diagnóstico de anemia foi realizado pela dosagem de hemoglobina capilar, sendo considerado quando a hemoglobina era menor que 11g/dL.Resultados: Encontramos 1,3% de desnutrição atual; 6,1% de crianças com desnutrição crônica, e 6,3% com obesidade. Das 250 crianças avaliadas quanto à hemoglobina, 57,2% apresentaram anemia ferropriva. A prevalência maior de anemia ocorreu na faixa etária de 6 a 24 meses, assim como também a anemia de maior gravidade.Conclusão: Medidas preventivas devem ser implementadas nas creches, em particular, a orientação nutricional para a formação de hábitos alimentares saudáveis, tendo em vista as altas prevalências de anemia encontradas e as crescentes prevalências de obesidade, não identificadas até recentemente no contingente populacional de baixa renda."