gebhart/patrepeval huggingface dataset:
Alcohols as Alkylating Agents: Photoredox‐Catalyzed Conjugate Alkylation via In Situ Deoxygenation (2022)

The rapid exploration of sp<sup>3</sup> -enriched chemical space is facilitated by fragment-coupling technologies that utilize simple and abundant alkyl precursors, among which alcohols are a highly desirable, commercially accessible, and synthetically versatile class of substrate. Herein, we describe an operationally convenient, N-heterocyclic carbene (NHC)-mediated deoxygenative Giese-type addition of alcohol-derived alkyl radicals to electron-deficient alkenes under mild photocatalytic conditions. The fragment coupling accommodates a broad range of primary, secondary, and tertiary alcohol partners, as well as structurally varied Michael acceptors containing traditionally reactive sites, such as electrophilic or oxidizable moieties. We demonstrate the late-stage diversification of densely functionalized molecular architectures, including drugs and biomolecules, and we further telescope our protocol with metallaphotoredox cross-coupling for step-economic access to sp<sup>3</sup> -rich complexity.
An Adaptive Sequential Linear Programming Algorithm for Optimal Design Problems With Probabilistic Constraints (2006)

Optimal design problems with probabilistic constraints, often referred to as reliability-based design optimization problems, have been the subject of extensive recent studies. Solution methods to date have focused more on improving efficiency rather than accuracy and the global convergence behavior of the solution. A new strategy utilizing an adaptive sequential linear programming (SLP) algorithm is proposed as a promising approach to balance accuracy, efficiency, and convergence. The strategy transforms the nonlinear probabilistic constraints into equivalent deterministic ones using both first order and second order approximations, and applies a filter-based SLP algorithm to reach the optimum. Simple numerical examples show promise for increased accuracy without sacrificing efficiency.
IoT Architecture Based on ABAC Smart Contract (2020)

In recent years, the combination of IoT and daily life is increasing. However, incidents caused by IoT security problems have also emerged endlessly. This paper analyzes the requirements of current IoT structure and the benefits of the combination of blockchain and IoT in this environment. Based on this, this paper uses the smart contract to implement the ABAC access control model on the blockchain and combines the IPFS file system to build a decentralized IoT architecture that can provide secure access control. The prototype of this system is tested in this paper, which verifies the feasibility of the system and confirms certain performance advantages of the architecture.
Optimizing Paths in OSPF Routing (2006)

Open shortest path first (OSPF) is the most commonly used Internet routing protocol. Traffic flows in OSPF routing go along shortest paths and the traffic will be split evenly when several shortest paths are found to the destination. An integer value is assigned for each link as a weight in OSPF networks. Weights highly affect the selection of links in the shortest paths. One of the standard heuristic recommended by Cisco is to set weights inversely proportional to the capacities of links. Overloaded links could appear if they have lower weights, while still other links unutilized. Many balance heuristics were proposed to avoid congestion and utilize un-used network resources. This paper presents an improvement for the evenly balancing heuristic proposed by Fortz and Thorup. Routing efficiency was improved when using our improved heuristic in terms of cost and max-utilization.
Collection of available solar process heat related national and trans-national research and funding programs (2021)

Within Task 64/IV Solar Process Heat, Subtask E Guideline to Market is aiming to support a wider penetration of solar thermal technologies in the supply of heating (and cooling) in industry, demonstrating Solar Heat for Industrial Processes (SHIP) to be an important contribution to the decarbonisation of the industrial sector. This requires not only to overcome technical and/or technological barriers, but it is crucial to also address on technical barriers. Whereas well suited system integration strategies, design tools, standardized procedures or modular components are all in all paramount for the development of reliable and prompt off the shelve solutions, experience shows that often non-technological barriers might have a critical role in the decision making process. Above all, competitiveness and investment/financing related barriers prove in many cases to be the bottleneck for the adoption of solar thermal technologies in the industrial framework.
Edward J Rice and flow control studies for jets and shear layers at NASA Glenn Research Center (2016)

Dr. Edward (Ed) J Rice’s most notable technical contributions are in the areas of duct acoustics and sound-absorbing liner technology, which are the subjects of several of the articles in this special issue. Starting in 1984 until his retirement in 1993, Dr. Rice led a “shear flow control” effort at NASA Glenn Research Center. Both authors of this article were part of that effort under his supervision. This article provides a brief overview of the various aspects of that effort, in the form of a narrative with minimal technical details. It covers research areas in which Ed had direct and indirect contributions and includes some activities that continued after his retirement through the mid-1990s.
MMSE-based linear parallel interference cancellation in long-code CDMA (2002)

Parallel interference cancellation (PIC) is a promising detection technique for multiuser code-division multiple access (CDMA) systems. It has previously been shown that weighted multistage PIC can be seen as a realisation of the steepest descent method for minimising the mean squared error (MSE). Following this interpretation, a unique set of weights, based on the eigenvalues of the correlation matrix, leads to the minimum achievable MSE for a short-code CDMA system. In this paper, we develop a method for finding a set of fixed weights, minimising the ensemble average of the MSE over all code-sets. Exact expressions of the ensemble averaged moments of the eigenvalues are derived. Simulation results show that a few stages can be sufficient for near-MMSE performance.
Exclusive breastfeeding in hospital predicts longer breastfeeding duration in Canada: Implications for health equity (2018)

Exclusive breastfeeding in hospital is associated with longer breastfeeding duration, particularly among women of lower socioeconomic status. Initiatives that support exclusive breastfeeding of newborns in hospital could improve long-term breastfeeding rates and help reduce health inequities arising in early life.
2D high-lift airfoil noise measurements in an aerodynamic wind tunnel (2015)

International audience
Meristematic Activity during Adventitious Root Primordium Development (1972)

Intact brittle willows (Salix fragilis L.) were treated so that developing adventitious root primordia in the stems would be subjected to elevated gibberellic acid or reduced endogenous auxin levels. Observations were made of primordia that were initiated during the experiments and of primordia that were established before the experiments began. The results indicated that as primordia became older and contained more cells, auxin basipetally transported in the stem seemed to be of less importance in determining cell number per primordium. Thus, established primordia depended upon this auxin to a lesser extent than primordia which were being initiated. These observations were explained on the basis of differential contributions during primordium development of cell division in the cambium of the stem and in the primordia themselves. As opposed to the effects of reduced auxin levels, applied gibberellic acid reduced the cell number per primordium most in established primordia. Initiating primordia were least affected by gibberellic acid treatment. Gibberellic acid treatment seemed mainly to reduce intraprimordium cell division, on which continued development of established primordia most depends. Seemingly, at least in brittle willow, applied gibberellic acid blocks the action of auxin in primordium development subsequent to the initiation phase.
Properties of CeO 2 –Al 2 O3–SiO 2 Glasses Prepared in Air (1996)

Properties of 15–30 mol% CeO 2 /23 mol% Al 2 O 3 /62–47 mol% SiO 2 glasses prepared in air have been investigated in this study. Experimental results show that the glass transformation temperature, the dilatometric softening temperature, and the transmittance in the visible region decrease with increasing ceria content; but the thermal expansion coefficient, the bulk density, and the microhardness increase with increasing ceria content.
Metabolic Response to Fasting in Experimental Intrauterine Growth Retardation Induced by Surgical and Nonsurgical Maternal Stress (1977)

Experimental intrauterine growth retardation was produced in two groups of neonatal rats by maternal sham surgery or by maternal obligatory exercise during the last 5 days of gestation (forced swim). Both experimental groups of neonates had lower plasma glucose and higher plasma insulin levels than controls after a 4-hour fast. Fetal stunting may be produced by a variety of maternal stresses in the rat and may be associated with alterations in the hormonal and glycemic response to fasting. Studies of the metabolic effects of experimental intrauterine growth retardation must be interpreted with caution if control animals have been subjected to intrauterine stress.
An automated large volume on‐column injection technique for capillary gas chromatography (1989)

Abstract Automated large volume (25‐200 μl) on‐column injections into a gas chromatograph with a capillary column were successfully performed by coupling a retention gap technique with an air actuated rotary valve. The linearity, injection precision, and carryover were evaluated. Slight boiling point discrimination was observed. This technique is compatible with commonly used chromatographic detectors (FID, ECD, MS) and conditions, while requiring very little instrument modification. The work is directed at the eventual reduction of manpower and turnaround time for sample collection and extraction, and Kuderna‐Danish concentration when dealing with methods similar to EPA 625.
Amperometric microbiosensors for detection of hydrogen peroxide and glucose based on peroxidase‐modified carbon fibers (1994)

Abstract A mediatorless amperometric microbiosensor can be constructed by immobilizing horseradish peroxidase (HRP) onto the surface of carbon fibers Several types of carbon fibers were tested. The best microelectrode, constructed by immobilizing HRP on high modulus. type (GH) carbon fibers, presented a linear response range between 20 μM and 2.5 mM H 2 O 2 and a detection limit of 0. 2 μM H 2 O 2 calculated as twice the signal‐to‐noise ratio. When HRP was coimmobilized with hydrogen peroxide‐producing glucose oxidase (GOD), a glucose sensor could be constructed with a linear potential range between 20 and 160 μM glucose, with a detection limit of 20 μM. The detection of the substrates was performed at a working potential of 0 mV ( vs . SCE) at pH 6.0.
Genomic Analysis of the Emergence and Rapid Global Dissemination of the Clonal Group 258 Klebsiella pneumoniae Pandemic (2015)

Multidrug-resistant Klebsiella pneumoniae producing the KPC carbapenemase have rapidly spread throughout the world, causing severe healthcare-associated infections with limited antimicrobial treatment options. Dissemination of KPC-producing K. pneumoniae is largely attributed to expansion of a single dominant strain, ST258. In this study, we explore phylogenetic relationships and evolution within ST258 and its clonal group, CG258, using whole genome sequence analysis of 167 isolates from 20 countries collected over 17 years. Our results show a common ST258 ancestor emerged from its diverse parental clonal group around 1995 and likely acquired blaKPC prior to dissemination. Over the past two decades, ST258 has remained highly clonal despite diversity in accessory elements and divergence in the capsule polysaccharide synthesis locus. Apart from the large recombination event that gave rise to ST258, few mutations set it apart from its clonal group. However, one mutation occurs in a global transcription regulator. Characterization of outer membrane protein sequences revealed a profile in ST258 that includes a truncated OmpK35 and modified OmpK37. Our work illuminates potential genomic contributors to the pathogenic success of ST258, helps us better understand the global dissemination of this strain, and identifies genetic markers unique to ST258.
Color tunable single-phase Eu2+and Ce3+co-activated Sr2LiAlO4phosphors (2019)

Color tunable single-phase phosphors (blue- to green-emitting) were fabricated with co-activators that also improved the quantum efficiency.
Subthreshold characteristics of p-type triple-gate MOSFETs (2004)

The fabrication and characterization of triple-gate p-type metal-oxide semiconductor field effect transistors (p-MOSFETs) on SOI material with multiple channels is described. To demonstrate the beneficial effects of the triple-gate structure on scaling, the output and transfer characteristics of 70 nm printed gate length pMOSFETs with 22 nm MESA width are presented. The geometrical influence of triple-gate MESA width on subthreshold behavior is investigated in short- and long channel devices. The temperature dependence of subthreshold characteristics is discussed.
High performance AXI-4.0 based interconnect for extensible smart memory cubes (2015)

The recent technological breakthrough represented by the Hybrid Memory Cube is on its way to improve bandwidth, power consumption, and density. This is while heterogeneous 3D integration has provided another opportunity for revisiting near memory computation to fill the gap between the processors and memories even further. In this paper, we take the first step towards a Smart Memory Cube (SMC), a fully backward compatible and modular extension to the standard HMC, supporting near memory computation on its Logic Base (LoB), through a high performance interconnect designed for this purpose. The main feature of SMC is the high bandwidth, low latency, and AXI-4.0 compatible interconnect, designed to serve the huge bandwidth demand by HMC's serial links, and to provide extra bandwidth to a processor-in-memory (PIM) embedded in the Logic Base (LoB). Our results obtained from cycle accurate simulation demonstrate that this interconnect can easily meet the demands of current and future projections of HMC (Up to 87GB/s READ bandwidth with 4 serial links and 16 memory vaults, and 175GB/s with 8 serial links and 32 memory vaults, for injected random traffic). Moreover, the interference between the PIM traffic and the main links was found to be negligible with execution time increase of less than 5%, and average memory access time increase of less than 15% when 56GB/s bandwidth is requested by the main links and 15GB/s bandwidth is delivered to the PIM port. Moreover, preliminary logic synthesis with Synopsys Design Compiler confirms that our interconnect is implementable and realistic.
Enabling high‐speed asynchronous data extraction and transfer using DART (2010)

Abstract As the complexity and scale of applications grow, managing and transporting the large amounts of data they generate are quickly becoming a significant challenge. Moreover, the interactive and real‐time nature of emerging applications, as well as their increasing runtime, make online data extraction and analysis a key requirement in addition to traditional data I/O and archiving. To be effective, online data extraction and transfer should impose minimal additional synchronization requirements, should have minimal impact on the computational performance and communication latencies, maintain overall quality of service, and ensure that no data is lost. In this paper we present Decoupled and Asynchronous Remote Transfers (DART), an efficient data transfer substrate that effectively addresses these requirements. DART is a thin software layer built on RDMA technology to enable fast, low‐overhead, and asynchronous access to data from a running simulation, and supports high‐throughput, low‐latency data transfers. DART has been integrated with applications simulating fusion plasma in a Tokamak, being developed at the Center for Plasma Edge Simulation (CPES), a DoE Office of Fusion Energy Science (OFES) Fusion Simulation Project (FSP). A performance evaluation using the Gyrokinetic Toroidal Code and XGC‐1 particle‐in‐cell‐based FSP simulations running on the Cray XT3/XT4 system at Oak Ridge National Laboratory demonstrates how DART can effectively and efficiently offload simulation data to local service and remote analysis nodes, with minimal overheads on the simulation itself. Copyright © 2010 John Wiley &amp; Sons, Ltd.
Microfluidic enrichment of small proteins from complex biological mixture on nanoporous silica chip (2011)

The growing field of miniaturized diagnostics is hindered by a lack of pre-analysis treatments that are capable of processing small sample volumes for the detection of low concentration analytes in a high-throughput manner. This letter presents a novel, highly efficient method for the extraction of low-molecular weight (LMW) proteins from biological fluids, represented by a mixture of standard proteins, using integrated microfluidic systems. We bound a polydimethylsiloxane layer patterned with a microfluidic channel onto a well-defined nanoporous silica substrate. Using rapid, pressure-driven fractionation steps, this system utilizes the size-exclusion properties of the silica nanopores to remove high molecular weight proteins while simultaneously isolating and enriching LMW proteins present in the biological sample. The introduction of the microfluidic component offers important advantages such as high reproducibility, a simple user interface, controlled environment, the ability to process small sample volumes, and precise quantification. This solution streamlines high-throughput proteomics research on many fronts and may find broad acceptance and application in clinical diagnostics and point of care detection.
Effect of Short Pulse Width Programming in AutoCapture Devices (2005)

Pacing chronaxie can increase over time. The impact of a short pulse duration on threshold (THR) variations, frequency of noncapture episodes, and overall patient safety has not been fully studied. AutoCapture (AC) pacemakers are capable of memorizing THR trends and loss of capture (LOC) episodes. The study included 20 recipients of AC pacemakers (mean age = 76 +/- 9 years, 15 men) followed for 6 months. They were randomly assigned to pulse durations of 0.2 versus 1.0 ms at 1 month, and crossed over to the alternate programming at 3 months. Evoked response (ER) and AC tests were performed at follow-up. At 0.2 ms and 1.0 ms, the mean number of LOC/day was 2.37 +/- 5.81 and 0.91 +/- 0.49, respectively (ns). LOC trends between follow-up were significantly different with 0.2 versus 1.0 ms pulse duration (P < 0.01). AC THR at 1.0 ms was significantly lower (0.44 +/- 0.77) than at 2.0 ms (0.97 +/- 0.26, P < 0.05). No patient reported symptoms related to LOC during the study. Pulse duration programmed near the strength-duration curve is associated with greater variations in THR and LOC. AC responds to these changes by delivering 4.5 V pulses and keeping the capture THR at low, though safe values.
RESEARCHES ON QUINAZOLINES (TWENTY-THIRD PAPER). ON 6-METHYL-7-AMINOQUINAZOLONES, 7-NITROQUINAZOLONE-6-CARBOXYLIC ACIDS, AND 1,3,7,9-NAPHTHOTETRAZINES.2 (1909)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRESEARCHES ON QUINAZOLINES (TWENTY-THIRD PAPER). ON 6-METHYL-7-AMINOQUINAZOLONES, 7-NITROQUINAZOLONE-6-CARBOXYLIC ACIDS, AND 1,3,7,9-NAPHTHOTETRAZINES.2Marston Taylor Bogert and Alfred H. KropffCite this: J. Am. Chem. Soc. 1909, 31, 9, 1071–1078Publication Date (Print):September 1, 1909Publication History Published online1 May 2002Published inissue 1 September 1909https://doi.org/10.1021/ja01939a017Request reuse permissionsArticle Views38Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (446 KB) Get e-Alertsclose Get e-Alerts
Dual Band Airborne Antenna Test Program. (1976)

Dual band antennas, operating at the C and Ku-bands with reasonable gain, good interband isolation and good radiation pattern symmetry can be fabricated for either vertical or horizontal polarization. Radiation patterns depict the expected volumetric coverage at four different locations on a UH-1 type aircraft fuselage for both vertical and horizontal polarization.
Halophenyl and 8-Quinolyl Carbonates. (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHalophenyl and 8-Quinolyl Carbonates.R. E. Stenseth, R. M. Schisla, and J. W. BakerCite this: J. Chem. Eng. Data 1964, 9, 3, 390–397Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/je60022a029https://doi.org/10.1021/je60022a029research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts