gebhart/patrepeval huggingface dataset:
Efferent Control of Hair Cell and Afferent Responses in the Semicircular Canals (2009)

The sensations of sound and motion generated by the inner ear are controlled by the brain through extensive centripetal innervation originating within the brain stem. In the semicircular canals, brain stem efferent neurons make synaptic contacts with mechanosensory hair cells and with the dendrites of afferent neurons. Here, we examine the relative contributions of efferent action on hair cells and afferents. Experiments were performed in vivo in the oyster toadfish, Opsanus tau. The efferent system was activated via electrical pulses to the brain stem and sensory responses to motion stimuli were quantified by simultaneous voltage recording from afferents and intracellular current- and/or voltage-clamp recordings from hair cells. Results showed synaptic inputs to both afferents and hair cells leading to relatively long-latency intracellular signaling responses: excitatory in afferents and inhibitory in hair cells. Generally, the net effect of efferent action was an increase in afferent background discharge and a simultaneous decrease in gain to angular motion stimuli. Inhibition of hair cells was likely the result of a ligand-gated opening of a major basolateral conductance. The reversal potential of the efferent-evoked current was just below the hair cell resting potential, thus resulting in a small hyperpolarization. The onset latency averaged about 90 ms and latency to peak response was 150-400 ms. Hair cell inhibition often outlasted afferent excitation and, in some cases, latched hair cells in the "off" condition for >1 s following cessation of stimulus. These features endow the animal with a powerful means to adjust the sensitivity and dynamic range of motion sensation.
A rapid hierarchical rendering technique for translucent materials (2005)

This paper introduces an efficient two-pass rendering technique for translucent materials. We decouple the computation of irradiance at the surface from the evaluation of scattering inside the material. This is done by splitting the evaluation into two passes, where the first pass consists of computing the irradiance at selected points on the surface. The second pass uses a rapid hierarchical integration technique to evaluate a diffusion approximation based on the irradiance samples. This approach is substantially faster than previous methods for rendering translucent materials, and it has the advantage that it integrates seamlessly with both scanline rendering and global illumination methods. We show several images and animations from our implementation that demonstrate that the approach is both fast and robust, making it suitable for rendering translucent materials in production.
Loss of diacylglycerol kinase ε causes thrombotic microangiopathy by impairing endothelial VEGFA signaling (2021)

Loss of function of the lipid kinase diacylglycerol kinase ε (DGKε), encoded by the gene DGKE, causes a form of atypical hemolytic uremic syndrome that is not related to abnormalities of the alternative pathway of the complement, by mechanisms that are not understood. By generating a potentially novel endothelial specific Dgke-knockout mouse, we demonstrate that loss of Dgke in the endothelium results in impaired signaling downstream of VEGFR2 due to cellular shortage of phosphatidylinositol 4,5-biphosphate. Mechanistically, we found that, in the absence of DGKε in the endothelium, Akt fails to be activated upon VEGFR2 stimulation, resulting in defective induction of the enzyme cyclooxygenase 2 and production of prostaglandin E2 (PGE2). Treating the endothelial specific Dgke-knockout mice with a stable PGE2 analog was sufficient to reverse the clinical manifestations of thrombotic microangiopathy and proteinuria, possibly by suppressing the expression of matrix metalloproteinase 2 through PGE2-dependent upregulation of the chemokine receptor CXCR4. Our study reveals a complex array of autocrine signaling events downstream of VEGFR2 that are mediated by PGE2, that control endothelial activation and thrombogenic state, and that result in abnormalities of the glomerular filtration barrier.
Multiscale characterization of a Fe based metallic glass: from its crystallization mechanism to its mechanical properties (2022)

International audience
THE FORGING PROCESS OF AIRCRAFT ENGINES TURBINE BLADES (2010)

The aim of this paper was to obtain information about optimum conditions of the forging process of a blade made from high-temperature creep resisting alloy called Inconel 718. A three-dimensional rigid-plastic finite element method (FEM) of forging process of high-pressure compressor rotor's blade analysis has been performed. Various forging process variants were analysed, including isothermal conditions.
Integrated electrical connector (2023)

An electrical connector is formed from a sheet of electrically conductive material that lies in between the two layers of nonconducting material that comprise the casing of an electrical chip. The connector is electrically connected to an electrical element embedded within the chip. An opening in the sheet is concentrically aligned with a pair of larger holes respectively bored through the nonconducting layers. The opening is also smaller than the diameter of an electrically conductive contact pin. However, the sheet is composed flexible material so that the opening adapts to the diameter of the pin when the pin is inserted therethrough. The periphery of the opening applies force to the sides of the pin when the pin is inserted, and thus holds the pin within the opening and in contact with the sheet, by friction. The pin can be withdrawn from the connector by applying sufficient axial force.
429: Postchemotherapy Retroperitoneal Lymph Node Dissection for Patients with Elevated Tumor Serum Markers (2005)

You have accessJournal of UrologyModerated Poster, Sunday, May 22, 2005, 1:00 - 3:00 pm1 Apr 2005429: Postchemotherapy Retroperitoneal Lymph Node Dissection for Patients with Elevated Tumor Serum Markers Zohar A. Dotan, Fernando J. Bianco, Jason P. Stasi, Robert J. Motzer, Dean F. Bajorin, George J. Bosl, and Joel Sheinfeld Zohar A. DotanZohar A. Dotan More articles by this author , Fernando J. BiancoFernando J. Bianco More articles by this author , Jason P. StasiJason P. Stasi More articles by this author , Robert J. MotzerRobert J. Motzer More articles by this author , Dean F. BajorinDean F. Bajorin More articles by this author , George J. BoslGeorge J. Bosl More articles by this author , and Joel SheinfeldJoel Sheinfeld More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34682-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "429: Postchemotherapy Retroperitoneal Lymph Node Dissection for Patients with Elevated Tumor Serum Markers." The Journal of Urology, 173(4S), p. 117 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 117 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Zohar A. Dotan More articles by this author Fernando J. Bianco More articles by this author Jason P. Stasi More articles by this author Robert J. Motzer More articles by this author Dean F. Bajorin More articles by this author George J. Bosl More articles by this author Joel Sheinfeld More articles by this author Expand All Advertisement PDF downloadLoading ...
Investigation of human haemotropic Mycoplasma infections using a novel generic haemoplasma qPCR assay on blood samples and blood smears (2010)

The aim of this study was to develop quantitative real-time (q)PCR assays to detect all known haemoplasma species, and a human housekeeping gene in order to demonstrate both successful DNA extraction from clinical samples and to test for sample inhibition, and to apply these qPCRs to human blood samples and blood smears. Sensitive and specific generic haemoplasma qPCR assays were developed to amplify haemoplasma species, as well as human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an internal amplification control. An optimized technique for extracting DNA from stained blood smears was also developed. These methods were applied to anonymized blood samples obtained from 100 human immunodeficiency virus (HIV)-infected South Africans and 920 UK patients undergoing haematological examination, and to 15 blood smears recruited from previous studies describing human haemoplasmosis. Human GAPDH levels were acceptable in all but three of the blood samples and all but two of the blood smears. The latter could have arisen due to DNA degradation due to the old age (over 35 years) of these smears. Haemoplasma infection was found in one HIV-infected South African, but the species could not be characterized due to the very low levels of DNA present. This report describes novel extraction and qPCR methodologies for haemoplasma screening. Previously reported human haemoplasmosis based on cytological diagnosis alone should be viewed with caution.
GaN Light-Emitting Diodes for up to 5.5-Gb/s Short-Reach Data Transmission Over SI-POF (2014)

We report a high-speed data transmission over a 1-mm diameter step-index polymer optical fiber (SI-POF) with GaN light-emitting diodes (LEDs) operating at 435 and 475 nm. The modulation bandwidths of the LEDs at 40 mA were 180 and 300 MHz, respectively. A maximum bit rate of 5.5 Gb/s was achieved with a 475-nm GaN LED at -1.8-dBm fiber-coupled power over a 1-m SI-POF employing 4-pulse-amplitude modulation format. Compared with the performance of a high-speed red resonant-cavity LED under the same test setup, the chromatic dispersion reduces the potential of the GaN LED-based system when the transmission distance is longer than 30 m.
Reliability of point-of-care testing for glucose measurement in critically ill adults* (2005)

The magnitude of the differences in the glucose values offered by the four different methods of glucose measurement led to frequent clinical disagreements regarding insulin dose titration in the context of an insulin infusion protocol for aggressive glucose control.
Comparison of body composition assessment by DXA and BIA according to the body mass index: A retrospective study on 3655 measures (2018)

The small bias, particularly in patients with BMI between 16 and 18, suggests that BIA and DXA methods are interchangeable at a population level. However, concordance between BIA and DXA methods at the individual level is lacking, irrespective of BMI.
Author Reply to “Regarding ‘High Clinical Failure Following Latissimus Dorsi Transfer for Revision Massive Rotator Cuff Tears’” (2020)

We are writing in response to the letter from Dr. Neviaser, for whom we have great respect. We appreciate his letter, and he makes excellent points regarding the latissimus dorsi transfer as a salvage procedure. His previous study described 17 patients with previously failed rotator cuff repairs who showed increased range of motion and overall satisfaction with a latissimus dorsi transfer.1Birmingham P.M. Neviaser R.J. Outcome of latissimus dorsi transfer as a salvage procedure for failed rotator cuff repair with loss of elevation.J Shoulder Elbow Surg. 2008; 17: 871-874Abstract Full Text Full Text PDF PubMed Scopus (55) Google Scholar He also mentions in his letter that their mean ASES was 61/100 postoperatively. Setting patient expectations are important, and a final score of 61/100 in a relatively young person is not ideal, in our opinion. In addition, part of the reason we wrote our initial article2Muench L.N. Kia C. Williams et al.High clinical failure rate after latissimus dorsi transfer for revision massive rotator cuff tears.Arthroscopy. 2020; 36: 88-94Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar was to open the conversation for other potential options, such as a lower trapezius transfer or even a biologic graft augmentation. As mentioned in the editorial commentary,3Li X. Editorial commentary: Is it time to abandon the latissimus dorsi tendon transfer as a salvage procedure for patients with large irreparable rotator cuff tears that failed primary repair?.Arthroscopy. 2020; 36: 95-98Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar we wanted to show that despite exhausting various efforts, at least in our hands, the latissimus dorsi transfer did not give us the results we wanted for this young population. Dr. Neviaser is completely right, and we agree that you should not overlook the latissimus dorsi transfer, but take into account the variability and success it can provide patients for such an involved surgery. Download .pdf (1.17 MB) Help with pdf files ICMJE author disclosure forms Regarding “High Clinical Failure Rate After Latissimus Dorsi Transfer for Revision Massive Rotator Cuff Tears”ArthroscopyVol. 36Issue 9PreviewThe article in the January 2020 issue entitled “High Clinical Failure Rate After Latissimus Dorsi Transfer for Revision Massive Rotator Cuff Tears,” by Muench et al.,1 caught my interest, and after reading the article and the commentary by Li,2 I felt it necessary to comment. Full-Text PDF
Correlation between the loss of the transformed phenotype and an increase in superoxide dismutase activity in a revertant subclone of sarcoma virus-infected mammalian cells. (1982)

We have studied the effects of paraquat (methyl viologen), a herbicide that increases intracellular production of superoxide radical, on the viability of virus-transformed and nontransformed normal rat kidney (NRK) cells in culture. We have shown that a low concentration of paraquat (12.5 microM) is cytotoxic toward virus-transformed cell lines, including Kirsten sarcoma virus- and SV40-transformed NRK cells. The corresponding untransformed NRK cells were resistant to the same and a 4-fold higher concentration of paraquat. There was a good correlation between the susceptibility of transformed and untransformed cells to paraquat cytotoxicity and their ability to increase the superoxide dismutase (SOD) enzymatic activity. We found that paraquat is cytotoxic toward Kirsten sarcoma virus-transformed and SV40-transformed NRK cells which showed low intracellular SOD activity. The relationship between SOD activity and paraquat cytoxicity was strengthened by the finding that the tolerance of NRK cells to the drug was associated with high intracellular SOD activity. This report also describes the isolation of a revertant (revertant RE8G3) cell line derived from Kirsten sarcoma virus-transformed NRK cells after paraquat treatment which contains SOD activity at levels much higher than those found in NRK cells. This revertant is undistinguishable from NRK cells with respect to its lack of transformed cell properties. Not only are these cells normal morphologically but also they do not grow in soft agar, an in vitro property that closely correlates with in vivo tumorigenicity. Several biological and biochemical properties of RE8G3 cells, including growth characteristics, surface receptors for both transferrin and epidermal growth factor (EGF), and the EGF-dependent 32P phosphorylation of specific membrane polypeptides have been studied. The most interesting conclusion that can be drawn from these studies is that there is a correlation between loss of the transformed phenotype and an increase in both EGF receptors and EGF-dependent 32P phosphorylation of a m.w. 170,000 membrane-associated protein.
An adaptive function neural network(ADFUNN) for phrase recognition (2006)

We describe an adaptive function neural network (ADFUNN) by the authors (2005), and apply it to the natural language processing task of phrase recognition. ADFUNN is based on a linear piecewise neuron activation function that is modified by a novel gradient descent supervised learning algorithm. Linearly inseparable problems can he learned with ADFUNN, rapidly and without hidden neurons. We perform phrase recognition on a set of phrases from the Lancaster parsed corpus (LPC) by R. Garside, et al. (1987). Generalisation rises to 100% with 150 training patterns (out of a total of 254).
Studies of Hemostatic Mechanisms in Leukemia and Thrombocytopenia (1957)

Journal Article Studies of Hemostatic Mechanisms in Leukemia and Thrombocytopenia Get access Jessica H. Lewis, Jessica H. Lewis Search for other works by this author on: Oxford Academic Google Scholar Joseph H. Burchenal, Joseph H. Burchenal Search for other works by this author on: Oxford Academic Google Scholar Rose R. Ellison, Rose R. Ellison Search for other works by this author on: Oxford Academic Google Scholar John H. Ferguson, John H. Ferguson Search for other works by this author on: Oxford Academic Google Scholar Jeffress H. Palmer, Jeffress H. Palmer Search for other works by this author on: Oxford Academic Google Scholar M. Lois Murphy, M. Lois Murphy Search for other works by this author on: Oxford Academic Google Scholar Marjorie B. Zucker, Marjorie B. Zucker Search for other works by this author on: Oxford Academic Google Scholar Frances Morgan, Frances Morgan Search for other works by this author on: Oxford Academic Google Scholar Iris Rudin Iris Rudin Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 28, Issue 5, 1 November 1957, Pages 433–446, https://doi.org/10.1093/ajcp/28.5.433 Published: 01 November 1957 Article history Received: 22 May 1957 Accepted: 15 July 1957 Published: 01 November 1957
Thermomorphological and mechanical properties of vulcanized octenyl succinate/terpenoid-derivatized corn starch composites (2022)

Successive modification of starch with octenyl succinic anhydride (OSA) and plant-derived geraniol allows for a largely bio-derived starch derivative that can undergo facile reaction with elemental sulfur to generate sustainable composite materials.
Short-Range Ultra-Broadband Terahertz Communications: Concepts and Perspectives (2007)

We propose the concept of ultra-broadband terahertz communication, based on directed non-line-of-sight (NLOS) transmissions. Potential applications of such a system supporting multi-gigabit data rates are given, and put into the context of currently emerging WLANs/WPANs. The technology and propagation constraints serve as boundary conditions for the determination of the required antenna gain to support ultra-broadband communication. Resulting high-gain antenna requirements will necessitate highly directed transmissions. We propose the use of omni-directional dielectric mirrors to support directed NLOS paths. Their performance is investigated with ray-tracing simulations of a terahertz propagation channel in a dynamic office environment, which is calibrated with measured building-material and mirror parameters. We demonstrate that a directed NLOS path scheme will make a terahertz communication system robust to shadowing. Furthermore, we show that dielectric mirrors covering only parts of the walls will significantly enhance the signal coverage in a typical indoor scenario.
Anonymizing set-valued data by nonreciprocal recoding (2012)

Today there is a strong interest in publishing set-valued data in a privacy-preserving manner. Such data associate individuals to sets of values (e.g., preferences, shopping items, symptoms, query logs). In addition, an individual can be associated with a sensitive label (e.g., marital status, religious or political conviction). Anonymizing such data implies ensuring that an adversary should not be able to (1) identify an individual's record, and (2) infer a sensitive label, if such exists. Existing research on this problem either perturbs the data, publishes them in disjoint groups disassociated from their sensitive labels, or generalizes their values by assuming the availability of a generalization hierarchy. In this paper, we propose a novel alternative. Our publication method also puts data in a generalized form, but does not require that published records form disjoint groups and does not assume a hierarchy either; instead, it employs generalized bitmaps and recasts data values in a nonreciprocal manner; formally, the bipartite graph from original to anonymized records does not have to be composed of disjoint complete subgraphs. We configure our schemes to provide popular privacy guarantees while resisting attacks proposed in recent research, and demonstrate experimentally that we gain a clear utility advantage over the previous state of the art.
Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-K b molecules (2002)

Crosslinking of the T cell receptor has been proposed to be a prerequisite for T cell activation. Although the evidence supports this notion for CD4 T cells, the situation for CD8 T cells is less clear. Soluble class I monomers have been used to determine activation requirements in vitro with contradictory results. The possibility of transfer of peptide from soluble class I molecules onto class I molecules present on the surface of CD8 T cells, with ensuing presentation to other CD8 T cells, has been widely ignored. We show that monomeric and tetrameric class I molecules as well as free peptide can stimulate naive CD8 T cells in vitro. We generate and characterize CD8 T cells that express the OT-I T cell receptor (for K(b)/SIINFEKL) yet lack K(b) and D(b) molecules, and show that their activation requirements differ from their class I positive counterparts when stimulated with soluble K(b) molecules. By eliminating the confounding effect of peptide transfer, we unmask the true activation requirements for naive CD8 T cells and show that multivalent engagement of T cell receptors, as well as costimulation, is required for optimal stimulation.
Synthesis and characterization of rhodium–aluminum heterobimetallic complexes tethered by a 1,3-bis(diphenylphosphino)-2-propanoxy group (2019)

We demonstrate the synthesis and characterization of a new class of late transition metal-aluminum heterobimetallic complexes. A bridging ligand which both chelates the transition metal and binds the aluminum via an alkoxide was employed to impart stability to the bimetallic system. Novel rhodium-aluminum heterobimetallic complexes Rh(DPPE)(DPPP-O-Al<sup>i</sup>Bu<sub>2</sub>Cl) and Rh(DPPP-O-Al<sup>i</sup>Bu<sub>2</sub>)(DPPP-O-Al<sup>i</sup>Bu<sub>2</sub>Cl) are synthesized and spectroscopically characterized.
A Continuation Approach to Regularize the Reflection Tomography with a 3D Gaussian Filter (2009)

We present a continuation approach that uses a 3D Gaussian filter as the regularization operator for the reflection tomography. We start from a smooth model and large standard deviations for the Gaussian filter in order to obtain the low frequency compone
Nanostructured DNA Templates (2005)

We have developed methods for nanostructure fabrication relying on the size and shape of a polynucleotide to dictate the overall structure of an assemblage of individual semiconductor nanoparticles. Use of the circular plasmids pUCLeu4 and phi chi 174 when anchored to a suitably derivatized substrate yields arrays of semiconductor nanoparticles matching the shapes of the biopolymer stabilizer. The viability of the methodology was confirmed using high-resolution transmission electron microscopy and selected-area electron diffraction.
Catecholamine stimulation is associated with impaired myocardial O2 utilization in heart failure (2002)

The impairment in contractile responses to dobutamine and norepinephrine in DCM is associated with impaired myocardial O(2) extraction, and a shift toward a preference for glycolysis. A different myocardial metabolic pattern suggestive of increased oxidation of FFA with increased myocardial O(2) extraction was observed in the presence of combined beta(1)/beta(2) stimulation with isoproterenol or beta(2) stimulation (ISO+MET). These data suggest that beta(2)-AR stimulation in DCM shifts substrate preference toward FFA oxidation associated with greater M(v)O(2) requirements. These findings identify a putative metabolic effect of beta(2) -AR in DCM that may be deleterious.
Toward identification of TAL effector targeted susceptibility genes in black rot of cabbage caused by Xanthomonas campestris pv. campestris (2019)

International audience