gebhart/patrepeval huggingface dataset:
Data from Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant (2023)

&lt;div&gt;Abstract&lt;p&gt;Carbonic anhydrase IX (CA9) is a hypoxia-regulated, transmembrane protein associated with neoplastic growth in a large spectrum of human tumors. CA9 is expressed in nearly all clear-cell renal tumors; levels of CA9 expression predict prognosis and response to interleukin-2 therapy. These observations may be explained by a novel chaperone-like function of CA9, which allows it to serve as an immunoadjuvant and stimulate an adaptive immune response against tumor antigens. Classic heat shock proteins (HSP) such as HSP110 and HSP70 are up-regulated in response to cellular stress and function to protect intracellular proteins from aggregation. Similarly, CA9 formed complexes with client proteins and inhibited heat-induced aggregation and enabled refolding of denatured client protein. HSP released from injured cells activate an immune response. CA9 bound dendritic cells in a receptor-specific manner. Bound CA9 was internalized by dendritic cells and processed primarily through the proteosomal pathway. In a murine melanoma model, a complex of CA9 and gp100 generated a gp100-specific antitumor response. A soluble form of CA9 shed from tumor cells had the same chaperone-like functions, providing renal tumors and hypoxic cells with a mechanism for stimulating an immune response against extracellular antigens. Interleukin-2 treatment of patient renal tumors in short-term culture increased CA9 shedding, suggesting a strategy for augmenting the immunogenicity of renal tumors. CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response. [Mol Cancer Ther 2008;7(12):3867–77]&lt;/p&gt;&lt;/div&gt;
Heat- and Lignosulfonate-Treated Canola Meal as a Source of Ruminal Undegradable Protein for Lactating Dairy Cows (2005)

This experiment used 18 lactating Holstein cows in a 3 3 Latin square replicated 6 times to determine the effectiveness of processing with moist heat or moist heat combined with lignosulfonate (LSO 3 ) for increasing the ruminal undegradable fraction of canola meal for use as a protein supplement for lactating dairy cows. Diets were formulated to be isonitrogenous and contained one of 3 forms of canola meal; untreated canola meal (UCM), heat-treated canola meal (HTCM) or heatand LSO 3 -treated canola meal (LSO 3 CM). Total collection of urine and feces was taken from each cow during the last 5 d of each 42-d experimental period. Milk production was greater for cows fed the LSO 3 CM diet (36.6 kg/d) than for cows fed the UCM diet (34.8 kg/d) but did not differ from cows fed the HTCM diet (35.3 kg/d). Digestibility of crude protein was lower for cows supplemented with LSO 3 CM and they had reduced concentrations of ruminal ammonia N, blood urea N, and milk urea N compared with cows supplemented with UCM or HTCM. Dry matter intake and apparent digestibilities of neutral and acid detergent fiber were increased in cows fed the LSO 3 CM diet. Urinary N excretion (as % of N intake) was reduced in cows fed the LSO 3 CM diet. These results indicate that moist heat combined with LSO 3 treatment of canola meal was effective in increasing the proportion of crude protein digested in the lower digestive tract of lactating cows and was therefore used more effectively as a source of protein than UCM or HTCM.
CCDC 1969014: Experimental Crystal Structure Determination (2020)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Atomic Layer Deposition of Antimony Oxide on Hydrogen-terminated Silicon Substrates (2009)

Atomic layer deposition thin antimony oxide films on silicon substrates was investigated. Growth of small crystallites could be obtained by using triisopropylantimony (SbiPr3) and water. The deposition of thin continuous films succeeded after employing ozone and SbiPr3. The growth rate was significantly higher for the higher deposition temperature: 0.16 nm/cycle at 300 {degree sign}C compared to 0.06 nm/cycle at 200 {degree sign}C. X-ray photoelectron spectroscopy detected no impurities in the film other than adventitious carbon at surface. A composition ratio of antimony to oxide of 27/73 was found, suggesting the occurrence of the pentavalent oxide Sb2O5. The oxide is prone to sputter reduction during depth profiling. A chemical shift in the binding energy of the Sb photoemission peaks from the oxide to the Sb0 state clearly arises already after gentle argon sputtering. At temperatures up to 40 {degree sign}C the as-deposited films showed remarkably resistance to buffered oxide etch and nitric acid.
<title>Characteristics of doped fibre intrinsic optical fibre sensor probes for wide-range and high-temperature operation</title> (1998)

Rare earth doped fibres have made a significant impact upon the development of effective optical communications systems. The authors and others have extensively explored the use of these rare-earth doped materials in fibre optic high temperature probes, to enable measurements over a wide range
Surface Proteome Analysis of a Natural Isolate of Lactococcus lactis Reveals the Presence of Pili Able to Bind Human Intestinal Epithelial Cells (2013)

Surface proteins of Gram-positive bacteria play crucial roles in bacterial adhesion to host tissues. Regarding commensal or probiotic bacteria, adhesion to intestinal mucosa may promote their persistence in the gastro-intestinal tract and their beneficial effects to the host. In this study, seven Lactococcus lactis strains exhibiting variable surface physico-chemical properties were compared for their adhesion to Caco-2 intestinal epithelial cells. In this test, only one vegetal isolate TIL448 expressed a high-adhesion phenotype. A nonadhesive derivative was obtained by plasmid curing from TIL448, indicating that the adhesion determinants were plasmid-encoded. Surface-exposed proteins in TIL448 were analyzed by a proteomic approach consisting in shaving of the bacterial surface with trypsin and analysis of the released peptides by LC-MS/MS. As the TIL448 complete genome sequence was not available, the tryptic peptides were identified by a mass matching approach against a database including all Lactococcus protein sequences and the sequences deduced from partial DNA sequences of the TIL448 plasmids. Two surface proteins, encoded by plasmids in TIL448, were identified as candidate adhesins, the first one displaying pilin characteristics and the second one containing two mucus-binding domains. Inactivation of the pilin gene abolished adhesion to Caco-2 cells whereas inactivation of the mucus-binding protein gene had no effect on adhesion. The pilin gene is located inside a cluster of four genes encoding two other pilin-like proteins and one class-C sortase. Synthesis of pili was confirmed by immunoblotting detection of high molecular weight forms of pilins associated to the cell wall as well as by electron and atomic force microscopy observations. As a conclusion, surface proteome analysis allowed us to detect pilins at the surface of L. lactis TIL448. Moreover we showed that pili appendages are formed and involved in adhesion to Caco-2 intestinal epithelial cells.
<title>Upgradable sensing systems for the oil and gas industry</title> (1999)

Information from the reservoir can be used throughout its lifetime to make significant improvements to yield and operating costs. Traditional sensing methods, such as well logging using wireline techniques and installation of permanent gauges (both electronic and fiber optic sensors such as fiber Bragg grating sensors) either provide occasional snapshots of the reservoir or provide sensing systems which become dated and which usually do not survive over the lifetime of the reservoir. This paper reviews methods of instrumenting oil wells with sensing systems that can be upgraded throughout the lifetime of the reservoir. Applications shown include pressure sensors and distributed temperature sensing.
Figure S2 from Randomized Trial of Oral Cyclophosphamide and Veliparib in High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers, or <i>BRCA</i>-Mutant Ovarian Cancer (2023)

&lt;p&gt;Supplemental Figure S2. PAR levels in patient PBMC samples. Data shown in dark red are from patients who reported deleterious BRCA mutations, data shown in dark blue are from patients reporting wildtype BRCA status, and data in grey are from patients with unknown BRCA status.&lt;/p&gt;
Capabilities of a Shock Tube to Simulate Blast Loading on Structures (2011)

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Orphanin FQ, agonist of orphan opioid receptor ORL1, stimulates feeding in rats (1996)

It has long been known that opioids, whether administered exogenously or released endogenously, play a role in feeding behavior, and that blockade of opioid receptors with various antagonists can inhibit feeding. Recently, the orphan opioid receptor, ORL1, and its presumed ligand, orphanin FQ, have been identified in human and rodent brain, and show structural similarity to classical opioid receptors and peptides, respectively. While it has been shown that central administration of orphanin FQ induces hyperalgesia, the effects of this peptide on food intake have not been studied. In the present study, we report that central injection of orphanin FQ induces feeding in satiated rats and that this effect can be blocked by peripheral administration of the opioid antagonist naloxone.
Synthesis of glycopolymers and their multivalent recognitions with lectins (2010)

Synthetic carbohydrate ligands – also widely known as glycopolymers – are known to undergo numerous recognition events when interacting with their corresponding lectins. Interactions are greatly enhanced due to the multivalent character displayed by the large number of repeating carbohydrate units along the polymers (pendant glycopolymers); therefore, resulting what is called the “glycocluster effect”. Moreover, the strength and the availability of these multivalent recognitions can be tuned via the architecture of the glycopolymers. Hence, understanding the mechanistic interactions between the types of lectins (plant, animal, toxin and bacteria) with their synthetic ligands is crucial. This review focuses on the synthesis of pendant glycopolymers via various synthetic pathways (free radical polymerization, NMP, RAFT, ATRP, cyanoxyl mediated polymerization, ROP, ROMP and post-polymerization modification) and their interactions with their respectively lectins.
Unusual Extinction Spectra of Nanometer-Sized Silver Particles Arranged in Two-Dimensional Arrays (1996)

Two-dimensional arrays of 1000 Å silver particles were prepared by adsorption from colloidal suspensions onto glass slides derivatized with (3-mercaptopropyl)trimethoxysilane. By variation of the concentration of the colloidal suspensions, slides with different interparticle distances were obtained, and their extinction spectra were measured in water. A blue shift (up to 90 nm) and sharpening of the peak corresponding to the plasmon resonance was observed as the distance between particles decreased to a value comparable to, or less than, their diameter. The angular dependence of the extinction spectra was studied for s- and p-polarized light. The data are interpreted to result from coherent coupling of the plasmon resonances in closely spaced silver particles upon irradiation with light.
Distribution of thymocytes expressing gamma delta receptors in the murine thymus during development. (1990)

We have examined the appearance of thymocytes expressing gamma delta TCR within the developing thymus by using immunohistochemical techniques and flow cytometry in conjunction with the mAb 3A10, which recognizes a determinant associated with the constant region of the delta-chain. gamma delta+ Cells were first detected at day 16 of gestation, attained maximal levels at day 17 of gestation, and declined thereafter. By using the Ulex europeus agglutinin to identify medullary epithelial cells in situ, we observed a striking colocalization of gamma delta+ thymocytes and U. europeus agglutinin-positive medullary epithelial cells during late fetal and neonatal periods of development. In the thymuses of adult mice, gamma delta+ thymocytes were scattered throughout cortical and medullary areas of the thymus and most concentrated in the subcapsular areas of the thymus. Ultrastructural immunohistochemistry confirmed the close association between medullary thymic epithelial cells and gamma delta+ thymocytes in the neonatal thymus and also showed that some TCR-gamma delta molecules were patched to areas of contact with medullary epithelial cells. In contrast to the cellular distribution of either CD3 molecules or the TCR-alpha beta, where extensive intracellular labeling of thymocytes has been observed, cytoplasmic accumulation of delta-chain was not detected.
[Changes in cell immunity indexes under the influence of thymalin, thyroxine and fibronectin in patients with hyperplastic diseases of thyroid gland before and after the surgery]. (2001)

Changes in the cell immunity indexes under the influence of thymalin, thyroxin and fibronectin in vitral loading models were studied up in patients with hyperplastic diseases of the thyroid gland. Disbalance of the cell link immunity was revealed before the operation and, in particular, in the main subpopulations of lymphocytes as well as immunoregulating index lowering, which had intensified after the operation. In patients with toxic, nodose euthyroid goiter and chronic autoimmune thyroiditis the existence of (thyroxin- and thymalin) dependent control of the cell link immunity was determined. Application of fibronectin substituting therapy for correction of the hormone depending functional activity of lymphocytes in the early postoperative period in patients with hyperplastic diseases of thyroid gland was pathogenetically substantiated.
Bate- and Gamma-Ray Spectroscopy of 80mBr (1969)

Decay of 80m Br was investigated. The half-lives of the isomeric and the ground states of 80 Br were obtained to be 4.42±0.01 h. and 16.8±0.1 min, respectively. Beta-ray, gamm-ray and gamma-gamma coincidence studies were carried out and energies and relative intensities of beta and gamma transitions were determined. Kurie plot analyses of negatrons and positrons give the maximum energies of 2.000±0.016 MeV and 0.850±0.007 MeV, respectively. The 1.478 MeV 0 + level of 80 Se and the 1.320 MeV 0 + and 1.256 MeV 2 + levels of 80 Kr were confirmed.
Transcriptional Analysis of Marek's Disease Virus Glycoprotein D, I, and E Genes: gD Expression Is Undetectable in Cell Culture (2001)

The various alphaherpesviruses, including Marek's disease virus (MDV), have both common and unique features of gene content and expression. The entire MDV U(s) region has been sequenced in our laboratory (P. Brunovskis and L. F. Velicar, Virology 206:324-338, 1995). Genes encoding the MDV glycoprotein D (gD), glycoprotein I (gI), and glycoprotein E (gE) homologs have been found in this region, although no gG homolog was found. In this work, transcription of the tandem MDV gD, gI, and gE genes was studied and found to have both unique characteristics and also features in common with other alphaherpesviruses. MDV gD could not be immunoprecipitated from MDV GA-infected duck embryo fibroblast cells by antisera reactive to its TrpE fusion proteins, while gI and gE could be. When the gD gene was subjected to in vitro-coupled transcription-translation, the precursor polypeptide was produced and could be immunoprecipitated by anti-gD. Northern blot, reverse transcriptase PCR, and RNase protection analyses have shown that (i) no mRNA initiating directly from the gD gene could be detected; (ii) a large but low-abundance 7.5-kb transcript spanning five genes, including the one encoding gD, was seen on longer exposure; and (iii) transcription of the gI and gE genes formed an abundant bicistronic 3.5-kb mRNA, as well as an abundant 2.0-kb gE-specific mRNA. Therefore, the MDV gD gene expression is down-regulated at the transcription level in MDV-infected cell culture, which may be related to the cell-associated nature of MDV in fibroblast cells. Compared to the highly gD-dependent herpes simplex virus and the other extreme of the varicella-zoster virus which lacks the gD gene, MDV is an intermediate type of alphaherpesvirus.
User interaction of one-dimensional panoramic images for iPod Touch (2012)

Modern handheld devices such as smart phones and tablets have become popular for capturing and viewing panoramic images, but navigation in these devices is a challenging task due to small screen size. In this thesis work, investigation is done for similarities and differences between two user interaction techniques of one-dimensional cubical panorama images. This work is carried out on a fourth generation Apple iPod Touch. The first user interaction technique swipe (drag-based panning) is developed using touch-gestures, while the second technique look-around (device-orientation panning) is developed using motion-sensors such as gyroscope and accelerometer for device-orientation. Both these techniques were implemented for touch-screen devices for an angle of 360 degrees. In the swipe technique, the navigation is done by using finger movements on the screen, while in the look-around based panning technique the navigation is done by moving the device direction physically in space through an angle of 360 degrees. The experiments were conducted on 20 participants for the two panning techniques. The results have shown that the look-around based panning technique offers a better user interaction compared to swipe based panning technique. Look-around based panning technique is natural and more free to move physically in space. Swipe based panning technique is easy to use in some situations and it does not require any physical space to move around the system.
Physics and numerical simulation of single photon avalanche diodes (1997)

We present results of the numerical simulation of the transient behavior of shallow junction single photon avalanche diodes (SPAD's). We developed a bidimensional model for above breakdown simulations and show that the initially photogenerated charge density builds up locally by an avalanche multiplication process and then spreads over the entire detector area by a diffusion-assisted process. To model real geometries, we developed a simplified model based on the obtained results. The importance of the photon-assisted spreading mechanism is evaluated and compared with the diffusive one. The contribution of the photon-assisted mechanism is minor in these geometries. The model is compared with the experimental data on the avalanche leading edge and the timing resolution; the agreement is good. We conclude that the model can be considered to be a useful tool for the design of improved structures.
Role of natural killer T cells in host defence against cryptococcal infection. (2002)

Cryptococcosis is an opportunistic fungal infectious disease that often occurs in severely immunocompromised patients. Host defence against the causative microorganism is largely mediated by cellular immunity, and Th1 cytokines, such as IFN-gamma, play central roles in the host protective responses. IL-12 and IL-18 activate the synthesis of IFN-gamma by innate immune cells, including NK, NKT and gamma delta T cells and promote the differentiation of Th1-type acquired immune responses. Recently, NKT cells, which are involved in the recognition of glycolipid antigens, have attracted much attention based on their potent immunomodulating activities. Several studies have reported the role of this particular component of innate immune responses in tumor immunity and pathogenesis of autoimmune diseases. In this review, I outline the recent findings on the role of NKT cells in host defence against infectious microorganisms, with a special focus on our data emphasizing the importance of this subset of immunocytes in the development of acquired as well as early host protection against cryptococcal infection.
Artificial Manipulation of Voice in the Human by an Implanted Stimulator (2008)

Dynamic vocal fold manipulation seems promising in terms of versatility lacking with static approaches to voice control.
Is there any evidence of a “July effect” in patients undergoing major cancer surgery? (2014)

On the whole, the data confirm an absence of a July effect in patients undergoing major cancer surgery.
Broken living layers: Dislocations in active smectic liquid crystals (2022)

We show that dislocations in active two-dimensional (2D) smectic liquid crystals with underlying rotational symmetry are always unbound in the presence of noise, meaning the active smectic phase does not exist for nonzero noise in d=2. The active smectic phase can, like equilibrium smectics in 2D, be stabilized by applying rotational symmetry-breaking fields; however, even in the presence of such fields, active smectics are still much less stable against noise than equilibrium ones, when the symmetry-breaking field(s) are weak.
Effects of p38 MAPK Inhibition on Early Stages of Diabetic Retinopathy and Sensory Nerve Function (2010)

Purpose. p38 mitogen-activated protein kinase (MAPK) is known to play a regulatory role in inflammatory processes in disease. Inflammation has been linked also to the development of diabetic retinopathy in rodents. This study was conducted to evaluate the effect of a p38 MAPK inhibitor on the development of early stages of diabetic retinopathy in rats. Methods. Streptozotocin-diabetic rats were assigned to two groups-treated with the p38 MAPK inhibitor PHA666859 (Pfizer, New York, NY) and untreated-and compared with age-matched nondiabetic control animals. Results. At 2 months of diabetes, insulin-deficient diabetic control rats exhibited significant increases in retinal superoxide, nitric oxide (NO), cyclooxygenase (COX)-2, and leukostasis within retinal microvessels. All these abnormalities were significantly inhibited by the p38 MAPK inhibitor (25 mg/kgBW/d). At 10 months of diabetes, significant increases in the number of degenerate (acellular) capillaries and pericyte ghosts were measured in control diabetic rats versus those in nondiabetic control animals, and pharmacologic inhibition of p38 MAPK significantly inhibited all these abnormalities (all P < 0.05). This therapy also had beneficial effects outside the eye in diabetes, as evidenced by the inhibition of a diabetes-induced hypersensitivity of peripheral nerves to light touch (tactile allodynia). Conclusions. p38 MAPK plays an important role in diabetes-induced inflammation in the retina, and inhibition of p38 MAPK offers a novel therapeutic approach to inhibiting the development of early stages of diabetic retinopathy and other complications of diabetes.
Preparation and Characterization of Some Schiff Base Dioxime Metal Complexes (2010)

A dioxime (LH2), (1,4-diaminobenzene-N, N' -bis(2-butylidine-3-one oxime), reacts with Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) to yield dinuclear complexes of general formula (M2(LH)2)Cl2 with a metal to ligand ratio of 2:2 with M = Co(II) or Cu(II), while Ni(II) forms complex (Ni2(LH)2(H2O)2Cl2) with a metal to ligand ratio of 2:2, whereas Zn(II) and Cd(II) form complexes of general formula (M2(LH)(H2O)2Cl2) with a metal to ligand ratio of 2 :1 . All complexes were characterized by metal content analyses, IR, electronic spectra, magnetic susceptibility and conductivity measurements. The Co(II) and Cu(II) complexes are proposed to be square planar while the Ni(II) complex is proposed to be octahedral and the complexes of Zn(II) and Cd(II) are tetrahedral.