gebhart/patrepeval huggingface dataset:
231 The MHC Class II Transactivator, CIITA, is a Viral Restriction Factor for Human Oncogenic Retroviruses (2011)

We show that CIITA, the master regulator of MHC-II gene expression, inhibits the replication of HTLV-1 by targeting the viral transactivator Tax-1. CIITA and Tax-1 physically interact in vivo and the first 108 aminoacids of Tax-1 are necessary for this binding. Two adjacent regions (1-252 and 253-410) of CIITA bind independently to Tax-1, but only region 1-252 mediates Tax-1 inhibition, in agreement with the fact that CIITA residues from positions 64-124 are required to block Tax-1 transactivation. The CIITA inhibitory action on Tax-1 function correlates with the nuclear localization of CIITA and is independent of the transcription factor NF-YB, previously involved in CIITA-mediated inhibition of HTLV-2 Tax-2. CIITA severely impairs the physical and functional interaction of Tax-1 with the cellular co-activator PCAF, which is required for the optimal activation of HTLV-1 promoter. Accordingly, CIITA-inhibited transactivation of the viral LTR promoter by Tax-1, is rescued by the over-expression of PCAF. Together with the previously reported inhibition of two other human retroviruses, HIV-1 and HTLV-2, these findings support the idea that CIITA might have evolved as a general defense mechanism of the host against retroviruses, not only because it activates the immune response against the infectious agents, but also because of its intrinsic capacity to act as an endogenous viral restriction factor. This investigation was supported by University of Insubria “FAR” to GT; I.S.S. National Research Project on A.I.D.S. n° 40F.1 and 45G.1 to R.S.A.; Fondazione Cariplo grant 2008-2230 and AIRC, grant IG 8862 to R.S.A.
Nitrous Oxide and Serious Morbidity and Mortality in the POISE Trial (2013)

In this post hoc subanalysis, nitrous oxide was not associated with an increased risk of adverse outcomes in the POISE trial patients. This analysis was limited by the observational nature of the data and the lack of information on the concentration and duration of nitrous oxide administration. Further randomized controlled trial evidence is required.
Membrane Lipids ofAcholeplasma laidlawii (2007)

The sections in this article are 1 Introduction 2 2 H NMR Studies of the A. laidlawii Membrane Lipids 3 19 F NMR Spectroscopy of Membrane Lipids 4 Biographical Sketches Related Articles
A METHOD OF CONJUGATE SUBGRADIENTS FOR (1975)

An algorithm is described for finding the minimum of any convex, not necessarily differentiable, function f of several variables. The algorithm yields a sequence of points tending to the solution of the problem, if any, requiring only the calculation off and one subgradient off at designated points. Its rate of convergence is estimated for convex and for differentiable convex functions. For the latter, it is an extension of the method of conjugate gradients and terminates for quadratic functions.
Disruption of native and recombinant Escherichia coli in a high‐pressure homogenizer (1989)

The disruption of native and recombinant strains of Escherichia coli was studied using a high-pressure homogenizer (Microfluidizer). The cells were grown in both batch and continuous fermentations. Cell suspensions ranging from 4 to 175 g dry wt/L were investigated at disruption pressures ranging from 30-95 MPa and at up to five passes. For both types of cells, the fraction of cells disrupted was dependent on the growth rate and concentration of the cells, the disruption pressure, and the number of passes through the disruptor. A model is presented that correlates the fractional disruption with these operating variables. The recombinant strain disrupted more readily than the native strain; 95 to 98% disruption of the former was achieved in two to three passes at a pressure of 95 MPa.
Practical equine electrocardiography (2012)

Cardiac arrhythmias are commonly detected in the horse and, though the aetiologies of some are apparent from auscultation, the majority require further investigation to determine a diagnosis. The electrocardiogram (ECG) is a tool of great importance in equine practice. It informs diagnosis, provides information on prognosis and safety to ride and guides therapeutic interventions. This article aims to review the practical aspects of obtaining a diagnostic electrocardiogram trace from a horse and discusses the applications of electrocardiography in equine medicine. Please note: Wiley-Blackwell are not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Energy aware routing in heterogeneous multi-hop wireless networks (2012)

Energy efficiency in heterogeneous wireless networks has become an important design consideration due to the limited battery life of mobile terminals on one side, and the ever increasing operational expenses pertaining to energy expenditure on the other. In this paper, we present a routing protocol for multi-radio multi-hop wireless networks, which aims to achieve a trade-off between energy consumption in the network and routing delay, considering both the energy consumption at the devices and the link energy costs.We also present optimum routepath selection strategies by defining a utility function to minimize the energy consumption in the network while maximizing the network lifetime. We verify using simulations, the utility of the route-path selection strategies and the efficiency of the energy aware routing algorithm. It turns out that the proposed protocol is energy efficient in terms of path selection, with a slight compromise in the end-to-end delay.
Towards efficiency and portability (1996)

Article Towards efficiency and portability: programming with the BSP model Share on Authors: Mark Goudreau Department of Computer Science, University of Central Florida, Orlando, FL Department of Computer Science, University of Central Florida, Orlando, FLView Profile , Kevin Lang NEC Research Institute, 4 Independence Way, Princeton, NJ NEC Research Institute, 4 Independence Way, Princeton, NJView Profile , Satish Rao NEC Research Institute, 4 Independence Way, Princeton, NJ and University of California at Berkeley, Berkeley, CA NEC Research Institute, 4 Independence Way, Princeton, NJ and University of California at Berkeley, Berkeley, CAView Profile , Torsten Suel NEC Research Institute, 4 Independence Way, Princeton, NJ and University of California at Berkeley, Berkeley, CA NEC Research Institute, 4 Independence Way, Princeton, NJ and University of California at Berkeley, Berkeley, CAView Profile , Thanasis Tsantilas Department of Computer Science, Columbia University, New York, NY Department of Computer Science, Columbia University, New York, NYView Profile Authors Info & Claims SPAA '96: Proceedings of the eighth annual ACM symposium on Parallel Algorithms and ArchitecturesJune 1996 Pages 1–12https://doi.org/10.1145/237502.237503Online:24 June 1996Publication History 45citation447DownloadsMetricsTotal Citations45Total Downloads447Last 12 Months4Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
VERIFYING THE SINGLE BUNCH CAPABILITY OF THE NEW INJECTOR AT ELSA (2011)

In order to enhance the operating capabilities of the Bonn University Accelerator Facility, ELSA, a new injector is currently under commissioning. One of its main purpose is to allow a single pulse mode. The injector produces a single electron bunch with 1.5 A pulse current. Design and optimization of the injector have been performed with EGUN, PARMELA and numerical simulations based on the numerical integration of the paraxial equation. A 1 ns long pulse is produced by a thermionic electron source with 90 kV anode - cathode voltage, then compressed and pre-accelerated by a subsequent 500 MHz RF cavity and a four-cell travelling wave buncher. Finally, the bunch will be accelerated to 20 MeV by the main LINAC section. Measurements have been conducted concerning the resulting pulse length and pulse charge to confirm the predictions made by simulations and to investigate the efficiency of the injector system.
Multiple contacts investigation of single silicon nanowires with the active voltage contrast scanning electron microscopy technique (2018)

Abstract A method for analysing the formation of electrical contacts to single silicon nanowires (Si NWs) by exploiting scanning electron microscopy (SEM) images, using active secondary electrons voltage contrast, is presented. Our approach clearly demonstrates the advantages of the proposed technique in analysing multiple contacts to a single nanowire simultaneously, in comparison to the conventional voltage contrast technique, where only two contact structures can be analysed, mainly for studies of the material dopant’s profile. The SEM is equipped with an in-lens detector, which collects the secondary electrons generated during electron beam exposure of the sample. Biasing the contacts with different voltages has been used to analyse the metal to Si NW contacts. The secondary electrons are sensitive to the potential distribution and the contrast of the SEM image changes depending on the number of secondary electrons detected. The Si NWs also vary their contrast together with the electrodes if they are properly electrically contacted. The basic tools and fixtures required for such measurements, and the corresponding image processing algorithms are described.
Designing a wearable computer for lifestyle evaluation (2012)

A wearable computer, called eButton, has been developed for evaluation of the human lifestyle. This ARM-based device acquires multimodal data from a camera module, a motion sensor, an orientation sensor, a light sensor and a GPS receiver. Its performance has been tested both in our laboratory and by human subjects in free-living conditions. Our results indicate that eButton can record real-world data reliably, providing a powerful tool for the evaluation of lifestyle for a broad range of applications.
De novo variants in CELF2 that disrupt the nuclear localization signal cause developmental and epileptic encephalopathy (2020)

We report heterozygous CELF2 (NM_006561.3) variants in five unrelated individuals: Individuals 1-4 exhibited developmental and epileptic encephalopathy (DEE) and Individual 5 had intellectual disability and autistic features. CELF2 encodes a nucleocytoplasmic shuttling RNA-binding protein that has multiple roles in RNA processing and is involved in the embryonic development of the central nervous system and heart. Whole-exome sequencing identified the following CELF2 variants: two missense variants [c.1558C>T:p.(Pro520Ser) in unrelated Individuals 1 and 2, and c.1516C>G:p.(Arg506Gly) in Individual 3], one frameshift variant in Individual 4 that removed the last amino acid of CELF2 c.1562dup:p.(Tyr521Ter), possibly resulting in escape from nonsense-mediated mRNA decay (NMD), and one canonical splice site variant, c.272-1G>C in Individual 5, also probably leading to NMD. The identified variants in Individuals 1, 2, 4, and 5 were de novo, while the variant in Individual 3 was inherited from her mosaic mother. Notably, all identified variants, except for c.272-1G>C, were clustered within 20 amino acid residues of the C-terminus, which might be a nuclear localization signal. We demonstrated the extranuclear mislocalization of mutant CELF2 protein in cells transfected with mutant CELF2 complementary DNA plasmids. Our findings indicate that CELF2 variants that disrupt its nuclear localization are associated with DEE.
Solar force modeling of block IIR Global Positioning System satellites (1996)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
SUTURES ALONE ARE SUFFICIENT TO SUPPORT REGENERATION ACROSS A GAP IN THE CONTINUITY OF THE SCIATIC NERVE IN RATS (2000)

We have proposed that it is sufficient to provide a simple substratum on which regenerating axons may traverse a gap in a peripheral nerve. To test this hypothesis we set up a new experimental model in which sutures were used to bridge a 10 mm long defect in a peripheral nerve. A defect was created bilaterally in 25 rat sciatic nerves. The cut ends of the nerve were joined by three laps of a continuous suture, on one side with 8/0 polyamide (non-absorbable) and on the other with 8/0 polyglactin (absorbable), leaving a 7 mm gap. At two weeks a matrix that contained capillaries, fibroblast-like cells, and mononuclear cells had formed between the nerve endings, and the sutures were surrounded by foreign-body-like tissue reactions. At four weeks axons had grown into the distal nerve segment on both sides in 65%-90% of the cases as indicated by a response to the pinch reflex test and immunocytochemistry for presence of neurofilament protein. Axons were organised in minifascicles and these tended to grow larger as the demarcation of the entire regenerated segment by a perineurial-like structure improved with time. At 12 weeks axonal counts of cross-sections of the distal tibial trunk showed many myelinated nerve fibres but no significant difference in axonal counts or degree of myelination between the polyamide and polyglactin sides. The results show that conventional sutures alone are sufficient to support regeneration across a short gap in a peripheral nerve, a method that may be of potential clinical value.
Targeted expression of two proteins in neural retina using self-inactivating, insulated lentiviral vectors carrying two internal independent promoters. (2007)

The results of this study show that it is possible to construct dual promoter lentiviral vectors that reliably express two proteins in a cell-specific manner. Among the dual promoter vectors created for this study, we have identified two vectors that specifically target expression of both transgenes to cone cells and one vector that specifically targets expression of one transgene to cone cells and the other transgene to rod cells. The ability to create one lentiviral vector that is capable of targeting expression of multiple genes to single or multiple cells in vivo should prove very useful in the development and delivery of complex, combination therapies to diseased tissues.
Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 Targets MDM2 To Deregulate the p53 Tumor Suppressor Pathway (2009)

Cells infected by viruses utilize interferon (IFN)-mediated and p53-mediated irreversible cell cycle arrest and apoptosis as part of the overall host surveillance mechanism to ultimately block viral replication and dissemination. Viruses, in turn, have evolved elaborate mechanisms to subvert IFN- and p53-mediated host innate immune responses. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes several viral IFN regulatory factors (vIRF1 to vIRF4) within a cluster of loci, their functions being primarily to inhibit host IFN-mediated innate immunity and deregulate p53-mediated cell growth control. Despite its significant homology and similar genomic location to other vIRFs, vIRF4 is distinctive, as it does not target and antagonize host IFN-mediated signal transduction. Here, we show that KSHV vIRF4 interacts with the murine double minute 2 (MDM2) E3 ubiquitin ligase, leading to the reduction of p53, a tumor suppressor, via proteasome-mediated degradation. The central region of vIRF4 is required for its interaction with MDM2, which led to the suppression of MDM2 autoubiquitination and, thereby, a dramatic increase in MDM2 stability. Consequently, vIRF4 expression markedly enhanced p53 ubiquitination and degradation, effectively suppressing p53-mediated apoptosis. These results indicate that KSHV vIRF4 targets and stabilizes the MDM2 E3 ubiquitin ligase to facilitate the proteasome-mediated degradation of p53, perhaps to circumvent host growth surveillance and facilitate viral replication in infected cells. Taken together, the indications are that the downregulation of p53-mediated cell growth control is a common characteristic of the four KSHV vIRFs and that p53 is indeed a key factor in the host's immune surveillance program against viral infections.
Multi-period resource allocation at system edges - capacity management in a multi-provider multi-service Internet (2002)

Providing guaranteed QoS necessarily requires allocation of scarce resources. It is conceivable that at least at system edges scarcity of resources, exposed in the form of non-negligible (virtual) costs, will prevail to necessitate explicit allocation of resources as opposed to pure over-dimensioning. An example of this logic is constituted by the Differentiated Services (DiffServ) architecture. Often such resource allocation decisions are done on a multi-period basis because resource allocation decisions at a certain point in time may depend on earlier decisions and thus it can turn out sub-optimal to look at decisions in an isolated fashion. Therefore, we investigate a fairly large and diverse set of (network) QoS problems all of which deal with the problem of multi-period resource allocation at system edges. We devise a taxonomy for the classification of these problems and introduce a common mathematical framework under which these problems can be tackled. The ultimate goal of our work is to strive for solution techniques towards the generalized class of problems such that these are applicable in a number of scenarios which have so far not been regarded in an integrated fashion.
Graphene oxide for enhanced self-phase modulation in silicon nitride waveguides (2023)

Self-phase modulation (SPM) is an important third-order nonlinear optical process that has been widely used in many applications, such as broadband optical sources, optical diodes, optical spectroscopy, pulse compression, and many others. The ability to realize SPM based on-chip integrated photonic devices will reap attractive benefits of compact footprint, high stability, high scalability, and low-cost mass production. Here, we experimentally investigate enhanced SPM in silicon nitride (Si3N4) waveguides by integrating with 2D graphene oxide (GO) films. The on-chip integration of GO films is achieved on Si3N4 waveguides through a solution-based, transfer-free, layer-by-layer coating method with precise control of the film thickness. We use both picosecond and femtosecond optical pulses to perform detailed SPM measurements. Owing to the high Kerr nonlinearity of GO, the GO-coated waveguides show significantly improved spectral broadening for both the picosecond and femtosecond optical pulses compared to the uncoated waveguide, achieving a broadening factor of up to ~3.4 for a device with 2 layers of GO. Based on the experimental results which show good agreement with theory, we obtain an improvement in the waveguide nonlinear parameter by a factor of up to 18.4 and a Kerr coefficient (n2) of GO that is about 5 orders of magnitude higher than Si3N4. These results reveal the effectiveness of 2D GO films to improve the nonlinear performance of Si3N4 waveguides.
A 90nm CMOS Doherty Power Amplifier with Integrated Hybrid Coupler and Impedance Transformer (2007)

An OFDM capable Doherty PA is implemented in 90 nm CMOS with integrated quadrature hybrid and impedance transformer. The two amplifiers are optimized to minimize AM-PM distortion. The PA achieves 25 dBm Psa, using 1.4 V supply with 24% PAE, and operates over 1 GHz of frequency range (from 4 GHz to 5 GHz). 3 dB to 6 dB back-off from P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> is required to achieve -25 dB measured EVM across this band, making it suitable for WLAN and WiMAX applications. The measured AM-PM distortion varies from 4deg to 12.5deg across the 1 GHz range.
An identification problem in an urn and ball model with heavy tailed distributions (2008)

We consider in this paper an urn and ball problem with replacement, where balls are with different colors and are drawn uniformly from a unique urn. The numbers of balls with a given color are i.i.d. random variables with a heavy tailed probability distribution, for instance a Pareto or a Weibull distribution. We draw a small fraction $p\ll 1$ of the total number of balls. The basic problem addressed in this paper is to know to which extent we can infer the total number of colors and the distribution of the number of balls with a given color. By means of Le Cam's inequality and Chen-Stein method, bounds for the total variation norm between the distribution of the number of balls drawn with a given color and the Poisson distribution with the same mean are obtained. We then show that the distribution of the number of balls drawn with a given color has the same tail as that of the original number of balls. We finally establish explicit bounds between the two distributions when each ball is drawn with fixed probability $p$.
Intramedullary Versus Extramedullary Femoral Alignment Systems in Total Knee Replacement (1993)

The accuracy of intramedullary (IM) versus extramedullary (EM) distal femoral alignment systems was compared in 200 consecutive total knee replacements (TKRs) on standing full-length lower-extremity roentgenographs. Intramedullary femoral alignment systems were used in 125 TKRs and an EM system was used in 75 TKRs. All tibial cuts were made using an EM tibial cutting guide. Roentgenographic measurements of (1) femoral-tibial angle, (2) distal-femoral resection angle, (3) proximal-tibial resection angle, (4) joint line orientation, (5) physiologic femoral valgus, and (6) distance of the lower-extremity mechanical axis from the center of the knee were made. No significant intragroup differences were seen in the average values obtained for each of the six roentgenographic measurements. However, the percentage of distal-femoral resections outside the accepted normal range (94 degrees-100 degrees) was higher in the EM group (28%) versus the IM group (14.4%) at p = 0.019. Likewise, the percentage of joint line orientations outside the desired normal range was higher in the EM groups when compared with the IM group (21.3% versus 11.2%, p = 0.052). A disturbing number of proximal-tibial resection angles were inaccurate in both groups. Improper tibial cuts were seen in 20.6% of Group 1 and in 24% of Group 2 when an EM tibial cutting guide was used. A range of distal-femoral cuts exists when using either an IM or an EM femoral alignment guide. This study demonstrated a statistically significant improvement in distal-femoral resection accuracy when using an IM femoral alignment system. Methods of improving proximal-tibial bone resections are needed.(ABSTRACT TRUNCATED AT 250 WORDS)