gebhart/patrepeval huggingface dataset:
Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model (2018)

The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and chromatographic profiling of desalted and enzyme-digested SE ethanol extract (SE-EE). Subsequently, we evaluated the anti-neuroinflammatory and ameliorative potential of SE-EE in LPS-inflicted BV-2 microglial cells and scopolamine-induced amnesic C57/BL6N mice, respectively. SE-EE possess considerable polyphenols and flavonoids that are supposedly responsible to improve its bio-efficacy. SE-EE dose-dependently attenuated LPS-induced inflammation in BV-2 cells, significantly repressed behavioural/cognitive impairment, dose-dependently regulated the cholinergic function, suppressed oxidative stress markers, regulated inflammatory cytokines/associated proteins expression and effectively ameliorated p-CREB/BDNF levels, neurogenesis (DCX stain), neuron proliferation (Ki67 stain) in scopolamine-administered mice. Thus, SE-EE extract shows promising multifactorial disease modifying activities and can be further developed as an effective functional food, drug candidate, or supplemental therapy to treat neuroinflammatory mediated disorders.
Studies on Allergen and Allergoid Preparations from Purified Timothy <i>(Phleum pratense)</i> Pollen Extracts (1982)

Physicochemical and in vitro allergenic properties of two different preparations of timothy (Phleum pratense) pollen were compared. The refined allergen extract, timothy B, contained proteins of molecular weights from 10,000 to 45,000 daltons. The allergoid preparation, which was prepared by mild treatment of the partially purified extract with formaldehyde, possessed only a trace of activity in the RAST inhibition assay. The formaldehyde treatment also resulted in a shift of the net charge of proteins to the more acidic site, as demonstrated by isoelectric focusing. Furthermore, it was shown that the activities of naturally occurring enzymes of native allergen extracts were reduced considerably. Only traces of acid phosphatase activity could be demonstrated in timothy B allergoid.
Gaining the middleground: a linux-based open source middleware initiative (2000)

Central to the development of the Internet, and the resulting business paradigm shifts, has been the adoption of standards which have provided the necessary framework for computer systems to cooperate and exchange information. The next major step necessary to support the continuation of this process is the development of software protocols and tools which provide the ability to manage the delivery of services to users.

This paper describes a Linux-based middleware initiative which has been deployed at North Dakota State University to support a Category of Service information delivery system for the North Dakota Higher Education Computing Network. The system was designed to support a computing model where the majority of the service infrastructure is supplied by Linux servers and which is extensible to the 11 state institutions comprising the HECN.

The paper begins with a discussion of middleware and its importance in the development of next-generation information systems. Included in this discussion are the topics of identification, authentication and authorization and the requirement for them in a modern middleware solution. Central to this topic will be a discussion of the potential threat that proprietary middleware solutions pose to the continued penetration of Open Source efforts into the enterprise computing model.

The paper then discusses in detail the design and architecture of the User Services Management System which implements the middleware solution at NDSU. The three fundamental components discussed will be the User Services DataBase, LDAP meta-directory services and the User Account Management System.

Discussion of the system architecture will include details of how standard services have been modified to operate under middleware control.

The paper will conclude with a discussion of the implications of this work. Also included is a discussion of the next generation of the system architecture.
Blood-Brain Barrier Leakage (2019)

Background and Purpose- The diagnosis of transient ischemic attack is challenging. Evidence of acute ischemia on MRI diffusion-weighted imaging is highly variable and confirmed in only about one-third of patients. This study investigated the significance of blood-brain barrier dysfunction (BBBD) mapping in patients with transient neurological deficits, as a diagnostic and prognostic biomarker required for risk stratification and stroke prevention. Methods- We used dynamic contrast-enhanced MRI to quantitatively map BBBD in a prospective cohort study of 57 patients diagnosed with transient ischemic attack/minor stroke and 50 healthy controls. Results- Brain volume with BBBD was significantly higher in patients compared with controls ( P=0.002). BBBD localization corresponded with the clinical presentation in 41 patients (72%) and was more extensive in patients with acute infarct on diffusion-weighted imaging ( P=0.05). Patients who developed new stroke during follow-up had a significantly greater BBBD at the initial presentation ( P=0.03) with a risk ratio of 5.35 for recurrent stroke. Conclusions- This is the first description of the extent and localization of BBBD in patients with transient ischemic attack/minor stroke. We propose BBBD mapping as a valuable tool for detection of subtle brain ischemia and a promising predictive biomarker required for risk stratification and stroke prevention.
Direct Solid-Liquid Separation Using Hollow Fiber Membrane in an Activated Sludge Aeration Tank (1989)

Direct membrane separation using hollow fibers was applied to wastewater treatment in an activated sludge process. A membrane module with a pore size of 0.1 micron was immersed in the aeration tank and treated water was filtered through the membrane by suction. Various operational modes were applied to investigate stable flux conditions as well as organic and nitrogen removal. The stable treatment with a detention time of 4 hours could be kept for about 120 days at a volumetric organic loading of 1.5 kg COD/(m3 day) using intermittent suction with a low pressure of 13 kPa (1.3 m as water head). The COD removal was higher than 95% and more than 90% of COD supplied was oxidized to keep MLSS almost constant in the reactor without sludge wastage, which suggests that total oxidation of influent biodegradable materials can be achieved in this system. Up to 60% of nitrogen could be denitrified by intermittent aeration. The critical organic loading was estimated as 3 to 4 kg COD/(m3 day) in order to keep both stable flux and aerobic condition. The clogging in the membrane was inevitable to some extent, however, the intermittent suction and low pressure operation without cleaning could prevent the unrecoverable clogging and dead end of operation.
Micrometer-size Nd-Fe-B dots as model systems for the study of intergranular phase engineering in Nd-Fe-B permanent magnets (2014)

Nd-Fe-B micrometer-size dots were prepared by optical lithography and sputtering. It is proposed to use such structures as model systems to study intergranular phase engineering in Nd-Fe-B permanent magnets. The influence of Ta, Nd, Dy, and Gd coatings on the magnetization reversal of such Nd-Fe-B dot arrays are compared, after different heat treatments. A very thin layer of Dy (tNdFeB/tDy = 120) was found to lead to a significant increase of the coercive field, up to 80% for a total equivalent Dy content of less than 5 at. % of all the Nd. A coercivity increase of up to 20% was found with Gd coating which is attributed to the so-called superferrimagnetic coupling phenomenon. Nd and Ta coating are neutral or detrimental to the magnetic hardness.
Electrowetting-assisted drop deposition for controlled spotting (2007)

Electrowetting is used to assist the delivery of droplets by a contact method. The electroassisted liquid dispensing technique enables to monitor the drop size via the voltage applied between the tool, i.e., silicon cantilevers and the deposition surface. Voltages ranging from 0to210V are used to deposit water-glycerol drops with diameters and volumes in the ranges of 5–40μm and 20fL–14pL. The presented results demonstrate that electrowetting-assisted deposition is of special interest for patterning applications requiring large features to be directly and quickly written using a minimum volume of reagents.
Visual Perception Using a Blackboard Architecture (2020)

This chapter discusses the use of blackboard architecture in capturing both the general knowledge about the visual world and, at the same time, the high-level knowledge available for tackling the specialized domain at hand. The blackboard architecture is composed of three parts: a blackboard data structure, a set of knowledge sources, and a control mechanism. The features of the blackboard architecture with the extensions of blackboard dimensions, frame-based object models, and parallel activation of knowledge sources provide the necessary framework for integrating these knowledge sources. A computer system for the automatic interpretation of a television camera signal relies on knowledge of the world. The development of powerful mathematical models of the process of image formation and its relation to surface shape and other object characteristics is an important area for research in computer vision. Research in restricted domains, such as medical and industrial image interpretation, will lead to useful applications.
Palestinian Women and Collective Memory (2009)

When one deals with a complex topic such as the collective memory of Palestinian women, a number of questions regarding the very notion of collective memory immediately come to mind. First and foremost is the question whether Palestinian women are allowed an equal share in Palestinian collective memory. Or, in other words, how inclusive, indeed, how collective is collective memory? Assuming one can recognize the various layers and strata of collective memory, one should ask how women conceive their own collective story inside the general one. Do disenfranchised groups develop their own versions of collective memory, different from the general narrative commonly accepted by the majority? Do they remember a different past? Do they envision themselves as central, viable participants in it, or as marginal to it? Finally, where and when does the act of memorizing take place, particularly in the case of Palestinian women? This chapter will analyze the various implications of these questions in the light of the vast body of data, research material, and documents at hand.
5120-km RZ-DPSK transmission over G.652 fiber at 10 Gb/s without optical dispersion compensation (2005)

We report the longest unregenerated reach achieved for a 10-Gb/s return-to-zero differential phase-shift keying system on standard dispersion fiber (G.652) with no optical dispersion compensation. A total of 82.433 ns/nm of chromatic dispersion compensation was achieved.
Opsonized zymosan-stimulated granulocytes-activation and activity of the superoxide-generating system and membrane potential changes (1981)

Phagocytic cells generate superoxide in response to stimulation by opsonized particles. A continuous assay for opsonized zymosan-stimulated granulocyte superoxide production shows that there is a lag time between the addition of particles and the onset of detectable superoxide production. Superoxide production is preceded by membrane potential depolarization. Neither superoxide production nor membrane depolarization occurs in granulocytes from patients with chronic granulomatous disease. The extent of activation by opsonized zymosan is affected by the dose of zymosan from 0.5 to 4.5 mg/ml, but the time necessary for activation (lag time) is not. Similarly, the extent of depolarization but not the time necessary for attaining maximum depolarization is concentration-dependent. Effects of temperature, divalent cations, 2-deoxyglucose, cyanide, and N-ethyl maleimide on superoxide production are similar for granulocytes treated with soluble stimuli and with opsonized zymosan. Thus, zymosan stimulates granulocytes to generate superoxide and undergo membrane depolarization in a manner similar to that elected by soluble stimuli.
Application of Indocyanine Green Near-Infrared Fluorescence Imaging in Laparoscopic Colectomy for Metachronous Colon Cancer (2021)

Takahashi, Hidekazu M.D., Ph.D.; Ogino, Takayuki M.D., Ph.D.; Miyoshi, Norikatsu M.D., Ph.D.; Uemura, Mamoru M.D., Ph.D.; Yamamoto, Hirofumi M.D., Ph.D.; Mizushima, Tsunekazu M.D., Ph.D.; Doki, Yuichiro M.D., Ph.D.; Eguchi, Hidetoshi M.D., Ph.D.Author Information
Determinants of Self-Measured Pulse Rate Profile in Medicated Hypertensives: The Jichi Morning Surge–1 (JMS-1) Study (2008)

Smoking habit, diabetes, lack of ACE inhibitor use, and low BNP value were determinants of home PR, and female gender and higher HbA1c were significantly associated with its low variability. Home PR and its variability may be useful for detecting high-risk hypertensive patients, particularly with autonomic neuropathy.
Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease (1993)

The possibility of slowing the progression of Parkinson's disease (PD) with inhibitors of monoamine oxidase B (MAO B) has stimulated the development of new MAO B inhibitor drugs. Ro 19 6327 is a highly selective inhibitor of MAO B currently under clinical investigation. We used positron emission tomography (PET) and the MAO B tracer [11C]L-deprenyl to determine the degree and reversibility of human brain MAO B inhibition by Ro 19 6327 in six early Parkinson's disease patients who were treated with different doses of Ro 19 6327 (25 mg [n = 3], 50 mg [n = 2], and 100 mg [n = 1]; 0.34 to 1.4 mg/kg) every 12 hours for 1 week. Each patient had three PET scans to assess baseline MAO B activity, degree of trough inhibition, and reversibility. A control group of four elderly normal subjects was scanned twice to assess reproducibility of repeated measures. Four of the patients showed reduction of MAO B concentration to 1% to 7% of baseline on doses of 0.43 mg/kg or greater, and the remaining two at 0.34 mg/kg showed significant but incomplete inhibition (10% to 21% of baseline in the global region and in the thalamus, basal ganglia, and mesencephalon). Thus, 0.4 mg/kg or greater of Ro 19 6327 given every 12 hours is the minimum dose necessary to provide > 90% inhibition of brain MAO B in patients with early PD. Brain MAO B activity returned to baseline values by 36 hours after drug discontinuation.
Model-based image reconstruction by means of a constrained least-squares solution (1997)

The problem of the optimal use of object model information in image reconstruction is addressed. A closed-form solution for the estimated object spectrum is derived with the Lagrange multiplier technique, which assumes a measured image, knowledge of the optical transfer function, statistical information about the measurement noise, and a model of the object. This reconstruction algorithm is iterative in nature because the optimal Lagrange multiplier is not generally known at the start of the problem. We derive the estimator, describe one technique for determining the optimal Lagrange multiplier, demonstrate a stopping criterion based on the mean-square error between a noise-free image and the photon-limited version of the image, and show representative results for both filled- and sparse-aperture imaging applications.
Over-voltage protection strategies for LED based light source systems and other applications (2014)

LED based lightning systems require specific methodologies for protection implementation against electrical overstress, electrostatic discharge and various natural or artificial electromagnetic disturbances on the power lines. In this work we present a successful strategy to implement high-reliable system protection compliant to Class 2 of the EN61643-11:2002 + A11:2007 standard (or IEC/EN 61000-4-5), proved on actual products.
Advances in Graphene/Inorganic Nanoparticle Composites for Catalytic Applications (2022)

Graphene-based nanocomposites with inorganic (metal and metal oxide) nanoparticles leads to materials with high catalytic activity for a variety of chemical transformations. Graphene and its derivatives such as graphene oxide, highly reduced graphene oxide, or nitrogen-doped graphene are excellent support materials due to their high surface area, their extended π-system, and variable functionalities for effective chemical interactions to fabricate nanocomposites. The ability to fine-tune the surface composition for desired functionalities enhances the versatility of graphene-based nanocomposites in catalysis. This review summarizes the preparation of graphene/inorganic NPs based nanocomposites and their use in catalytic applications. We discuss the large-scale synthesis of graphene-based nanomaterials. We have also highlighted the interfacial electronic communication between graphene/inorganic nanoparticles and other factors resulting in increased catalytic efficiencies.
The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells (2005)

Mitochondria are dynamic organelles that change morphology by controlled fission and fusion events. Mitochondrial fission is regulated by a conserved protein complex assembled at the outer membrane. Human MTP18 is a novel nuclear-encoded mitochondrial membrane protein, implicated in controlling mitochondrial fission. Upon overexpression of MTP18, mitochondrial morphology was altered from filamentous to punctate structures suggesting excessive mitochondrial fission. Mitochondrial fragmentation was blocked in cells coexpressing either the mitochondrial fusion protein Mfn1 or Drp1(K38A), a dominant negative version of the fission protein Drp1. Also, a loss-of function of endogenous MTP18 by RNA interference (RNAi) resulted in highly fused mitochondria. Moreover, MTP18 appears to be required for mitochondrial fission because it is blocked after overexpression of hFis1 in cells with RNAi-mediated MTP18 knockdown. In conclusion, we propose that MTP18 functions as an essential intramitochondrial component of the mitochondrial division apparatus, contributing to the maintenance of mitochondrial morphology.
Negative Homotropic Cooperativity in Guest Binding of a Trisporphyrin Double Cleft (2023)

The negative homotropic allostery of a triple-layered trisporphyrin cleft with two guest binding sites is confirmed. The X-ray crystal structures of the 1 : 2 host-guest complexes showed that the trisporphyrin accommodated two guest molecules within the cleft through π-π stacking and donor-acceptor interactions. In solution, <sup>1</sup> H NMR and Job plots showed 1 : 2 host-guest complexes. Isothermal titration calorimetry (ITC) and UV/vis absorption spectroscopy were employed to evaluate the binding constants and cooperativities. The guest binding of the trisporphyrin showed negative cooperativity and non-cooperativity depending on the structures of the guest molecules. The correlations between the interaction parameters (α) and Hill constants were determined. ITC experiments showed that the host-guest complexation of trisporphyrin with electron-deficient guests incurred an enthalpy penalty in the successive guest binding process. DFT calculations revealed that binding of the first guest reduced the electron density of the central porphyrin plane, which led to an energetic penalty that weakened the successive binding process.
Bilateral Fat Necrosis of the Scrotum (1976)

The typical patient with fat necrosis of the scrotum is a prepuberal heavy set male subject who has extratesticular scrotal masses, usually bilateral, with mild to moderate pain but no systemic complaints or symptons related to voiding. The masses are firm, tender and do not transmit light. With a firm diagnosis expectant treatment will allow spontaneous resolution of the lesions. If doubt exists appropriate surgical intervention is advocated. Hypothermic injury, such as swimming in frigid water, is the most probable etiologic agent.
Radar Systems Analysis and Design Using MATLAB (2000)

Developed from the author's graduate-level courses, the first edition of this book filled the need for a comprehensive, self-contained, and hands-on treatment of radar systems analysis and design. It quickly became a bestseller and was widely adopted by many professors. The second edition built on this successful format by rearranging and updating
The Crystallization Technology Handbook, 2nd ed Edited by A. Marsmann. Marcel Dekker:  New York, Basel, Switzerland. 2001. ISBN 0-8247-0528-9. (2001)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTThe Crystallization Technology Handbook, 2nd ed Edited by A. Marsmann. Marcel Dekker: New York, Basel, Switzerland. 2001. ISBN 0-8247-0528-9.Joachim UlrichView Author Information Martin-Luther-Universität Halle-WittenbergCite this: Crystal Growth & Design 2001, 1, 5, 421Publication Date (Web):July 20, 2001Publication History Published online20 July 2001Published inissue 1 September 2001https://pubs.acs.org/doi/10.1021/cg0100179https://doi.org/10.1021/cg0100179book-reviewACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views782Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Crystallization,Crystals,Morphology Get e-Alerts
Symptomatology of Epileptic Seizures in the First Three Years of Life (1999)

The repertoire of seizure manifestation in the first 3 years of life appears to be limited. In infants, focal motor seizures are reliably associated with focal EEG seizures in the contralateral hemisphere, whereas generalized motor and hypomotor clinical seizures may be either focal or generalized on EEG. Epileptic spasms may be seen in focal as well as generalized epilepsies. Video-EEG monitoring and neuroimaging may be critical for clarifying the focal or generalized nature of the epilepsy in infants.
Control strategy of cooler for diminishing dimensions and extending service lifetime of inverter (2018)

The paper deals with the construction design and thermal simulation analysis of double three-phase converter suitable for electric vehicles. It gives a discussion on basic mechanical design and electric topology having both strong influence on electro-thermal operability. Finally, the paper presents thermal analyses of the converter operated at specified loading profile and discusses its impact on the converter lifetime.
Neointimal Hyperplasia After Arterial Injury Is Increased in a Rat Model of Non–Insulin-Dependent Diabetes Mellitus (2001)

The type II diabetic rat model, typifying insulin resistance, is associated with a propensity for neointima. The obese Zucker rat model may be an ideal diabetic model to further characterize the diabetic vascular response to injury.