gebhart/patrepeval huggingface dataset:
Dynamic evaluation of jack-up platform structure under wave, wind, earthquake and tsunami loads (2021)

Nowadays, the demand for using jack-up platforms to carry out a large percentage of deep-water oil and gas exploration is steadily increasing. The response of jack-up platforms to the severe dynamic loads that may be encountered during the structure life is not examined enough. Therefore, this study attempts to investigate the response of jack-up platforms performance under the effect of dynamic loads due to wave, wind, earthquake and tsunami forces using the finite element method for two models with the lowest and highest hull elevations. The jack-up platform is located in the Gulf of Mexico. Earthquake accelerations are applied to the model in high and moderate seismic levels. In addition, tsunami waves are applied to the platform in three different directions at 0°, 45° and 90°. This study utilised Airy's linear wave approach to assess the surface elevations and wave kinematics. The reference wind velocity is 10 knots at 10 m over the mean water level. Results indicate that the dynamic response of the structure is affected by the height of the platform and by the increase of the platform hull elevation. The combination of the El-Centro earthquake, dead and live loads provides the major impact on the platform at the lowest (70 m) and highest (85 m) hull elevations. The comparison of all result proves that the jack-up platform hull under high earthquake intensity and tsunami waves with 45° has experienced maximum deformation. Moreover, raising the deck will increase the response of the dynamic load and displacements but will negatively affect the platform.
Transductive and Inductive Methods for Approximate Gaussian Process Regression (2002)

Gaussian process regression allows a simple analytical treatment of exact Bayesian inference and has been found to provide good performance, yet scales badly with the number of training data. In this paper we compare several approaches towards scaling Gaussian processes regression to large data sets: the subset of representers method, the reduced rank approximation, online Gaussian processes, and the Bayesian committee machine. Furthermore we provide theoretical insight into some of our experimental results. We found that subset of representers methods can give good and particularly fast predictions for data sets with high and medium noise levels. On complex low noise data sets, the Bayesian committee machine achieves significantly better accuracy, yet at a higher computational cost. 1
Why Enzymes as Drug Targets? (2013)

This chapter contains sections titled: Key Learning Points Enzymes Are Essential for Life Enzyme Structure and Catalysis Permutations of Enzyme Structure During Catalysis Extension to Other Target Classes Other Reasons for Studying Enzymes Summary References
Isolation of Two Interleukin‐6 Response Element Binding Proteins from Acute Phase Rat Liversa (1995)

Proteins binding at the IL-6 response element of the rat alpha 2 macroglobulin gene were purified by a combination of conventional chromatographic procedures and binding-site specific DNA affinity chromatography. The proteins were purified from the nuclei of rat livers, excised at the peak of an experimentally induced acute phase response. By this procedure three polypeptides of 92, 91 and 86 kD were enriched more than 6,000-fold. Partial proteolysis with lysyl endopeptidase and aminoacid sequence analysis of proteolytic peptides identified the 86 and 91 kD species as the transcription factor Stat3 and the 92 kD species as a Stat factor distinct from Stats 1 and 3. cDNA clones for Stats 1, 3 and this 92 kD factor were isolated from a cDNA library prepared with mRNA from acute phase rat livers. Parts of their DNA sequences were determined and the sequences of the purified peptides were found in these cDNA sequences. Thus, the identity of the factors as Stat3 and a Stat factor different from Stats 1 and 3 was confirmed. These results suggest, that APRF/Stat3 and p91/Stat1 are not the only factors mediating the effects of IL-6 on class 2 acute phase genes. The 92 kD Stat factor binding at the IL-6 RE probably also functions as a transcription factor in the cytokine-induced activation of the alpha 2M gene.
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs (2010)

The β-amyloid peptide that accumulate in Alzheimer's disease (AD) brain derive from proteolytic processing of the amyloid precursor protein (APP). Recent evidence suggest that microRNAs (miRNAs) participate in the post-transcriptional regulation of APP expression. Because gene dosage effects of the APP gene can cause genetic AD, dysregulation of the miRNA network could contribute significantly to disease. Here, we present evidence that, besides APP expression regulation, miRNAs are equally involved in the regulation of neuronal APP mRNA alternative splicing. Lack of miRNAs in post-mitotic neurons in vivo is associated with APP exons 7 and 8 inclusion, while ectopic expression of miR-124, an abundant neuronal-specific miRNA, reversed these effects in cultured neurons. Similar results were obtained by depletion of endogenous polypyrimidine tract binding protein 1 (PTBP1) in cells, a recognized miR-124 target gene. Furthermore, PTBP1 levels correlate with the presence of APP exons 7 and 8, while PTBP2 levels correlate with the skipping of these exons during neuronal differentiation. Finally, we show that miR-124 is down-regulated in AD brain. In sum, our results suggest that specific miRNAs are involved in the fine-tuning of APP alternative splicing in neurons. Since abnormal neuronal splicing of APP affects β-amyloid peptide production, these results could contribute to the understanding of the implication of miRNAs in brain health and disease.
Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations (2017)

The phenotypic associations between atypical depressive symptoms and obesity-related traits may arise from shared pathophysiologic mechanisms in patients with MDD. Development of treatments effectively targeting immunometabolic dysregulations may benefit patients with depression and obesity, both syndromes with important disability.
Optimization of photon pair generation in dual-element PPKTP waveguide (2009)

A compact scheme for high-speed frequency doubling and down-conversion on a single dual-element PPKTP waveguide is investigated. Optimal temperature is achieved and photon pair coincidence is observed at over GHz repetition rate with pulsed pump input scheme.
Interactions between the mat‐forming algaDidymosphenia geminataand its hydrodynamic environment (2011)

Lay Abstract Algae require dissolved nutrients to grow, but nutrient concentrations are often very low in unpolluted streams and rivers. The supply of dissolved nutrients to benthic (bottom‐dwelling) algae increases with increasing river flow, but higher flows also produce drag forces that can damage the algae. To persist under high‐flow, low‐nutrient conditions, benthic algae must balance the conflicting requirements of minimal drag (to minimize detachment risks) and maximal exposure to turbulent flow (to maximize nutrient supplies). We explored flow‐algae interactions using the freshwater alga Didymosphenia geminata. D. geminata forms dense mats in swift, nutrient‐poor rivers, and is of particular interest because it is a highly invasive species in North American and New Zealand. To identify the properties that help D. geminata grow rapidly and resist detachment, we transplanted cobbles with attached D. geminata mats from a river to a laboratory flow chamber and measured flow properties above and within the mats. We then removed the mats from the cobbles and repeated the measurements. We found that water flow near the streambed is strongly altered in the presence of D. geminata mats. The dense, interwoven D. geminata stalks produce high friction and reduce flow fluctuations around and within the mats. The reduction in flow fluctuations around mats may reduce the risk of detachment and help retain dissolved nutrients within mats. We also found that D. geminata mats increase the roughness of riverbeds relative to bare cobbles, which may increase the rate of nutrient supply from the water to mat surfaces.
A Truncation-Depth Rule of Thumb for Convolutional Codes (2007)

Abstract — The commonly used rule of thumb of 5m for the truncation depth of a memory m convolutional code is accurate only for rate 1/2 codes and should be replaced by two to three times m/(1 − r) for a rate r code. I.
Grapevine field experiments reveal the contribution of genotype, the influence of environment and the effect of their interaction (G×E) on the berry transcriptome (2018)

Changes in the performance of genotypes in different environments are defined as genotype × environment (G×E) interactions. In grapevine (Vitis vinifera), complex interactions between different genotypes and climate, soil and farming practices yield unique berry qualities. However, the molecular basis of this phenomenon remains unclear. To dissect the basis of grapevine G×E interactions we characterized berry transcriptome plasticity, the genome methylation landscape and within-genotype allelic diversity in two genotypes cultivated in three different environments over two vintages. We identified, through a novel data-mining pipeline, genes with expression profiles that were: unaffected by genotype or environment, genotype-dependent but unaffected by the environment, environmentally-dependent regardless of genotype, and G×E-related. The G×E-related genes showed different degrees of within-cultivar allelic diversity in the two genotypes and were enriched for stress responses, signal transduction and secondary metabolism categories. Our study unraveled the mutual relationships between genotypic and environmental variables during G×E interaction in a woody perennial species, providing a reference model to explore how cultivated fruit crops respond to diverse environments. Also, the pivotal role of vineyard location in determining the performance of different varieties, by enhancing berry quality traits, was unraveled.
Photosensitized Oxidation of Carvomenthene1 (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotosensitized Oxidation of Carvomenthene1Robert L. Kenney and G. S. FisherCite this: J. Org. Chem. 1963, 28, 12, 3509–3512Publication Date (Print):December 1, 1963Publication History Published online1 May 2002Published inissue 1 December 1963https://pubs.acs.org/doi/10.1021/jo01047a057https://doi.org/10.1021/jo01047a057research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nanostructured Ball-Milled Ni–Co–Mn Oxides from Spent Li-Ion Batteries as Electrocatalysts for Oxygen Evolution Reaction (2023)

Discovering sources of transition metals, such as Ni, Co, and Mn, has become crucial due to their broad applicability, particularly as electrocatalysts for the oxygen evolution reaction (OER). Upcycled spent batteries have emerged as alternatives for transition metal sources for the OER electrocatalysts. In this work, Ni–Co–Mn oxalates were extracted from the spent LiNixCoyMnzO2 (NCM) cathode of lithium-ion batteries. The extracted oxalates were further processed via ball milling as a rapid and scalable mechanochemical route to engineer their structures. After calcination, Ni–Co–Mn oxides with nanosized granules on the surface that mainly consist of MnCo2O4 were obtained. With a correlation of morphology and trimetallic oxide formation with the OER catalytic performance, Ni–Co–Mn oxides exhibit OER overpotentials of 367 and 732 mV in alkaline and neutral media, respectively, showing OER catalytic activity in a wide pH range. The results indicate that ball milling can induce particle size reduction and bond formation between metals to facilitate mixed-metal oxide formation. Furthermore, the resulting material is also applicable as the catalyst in the air cathode of Zn-air batteries, where the battery achieved a power density of 85.42 mW cm–2 and 100 h of cycling stability, showing comparability with a battery with a Pt/C–Ir/C catalyst.
Development of an ASM2.0 RF system for maritime communications of high-data-rate in the VHF band (2015)

This paper presents a development of a RF system for the application specific message 2.0 (ASM2.0) which is a new maritime communication service in the VHF band. It contains a specification determination related to a RF system, some design points to support a complex modulation scheme for high-data-rate, and the implementation results. And, performances linked with a baseband (BB) system are also described.
Fourier-transform method of fringe-pattern analysis for computer-based topography and interferometry (1982)

A fast-Fourier-transform method of topography and interferometry is proposed. By computer processing of a noncontour type of fringe pattern, automatic discrimination is achieved between elevation and depression of the object or wave-front form, which has not been possible by the fringe-contour-generation techniques. The method has advantages over moiré topography and conventional fringe-contour interferometry in both accuracy and sensitivity. Unlike fringe-scanning techniques, the method is easy to apply because it uses no moving components.
Techno‐economic analysis of a lignocellulosic ethanol biorefinery with ionic liquid pre‐treatment (2011)

Abstract Lignocellulose dissolution in ionic liquids is a relatively new biomass pre‐treatment technology that is receiving growing interest from the biofuels community as a route to provide readily‐hydrolyzable holocellulose. Despite its proven advantages over other pre‐treatment technologies – including feedstock invariance, high monomeric sugar yields over short saccharification times, and extensive delignification – there are several core issues that stand in the way of commercialization. These include the relative high cost of the ionic liquids themselves, a lack of knowledge in terms of process considerations for a biorefinery based on these solvents, and scant information on the coproducts this pre‐treatment technology could provide to the marketplace. We present an initial techno‐economic model of a biorefinery that is based on the ionic liquid pre‐treatment technology and have identified, through a comprehensive sensitivity analysis, the most significant areas in terms of cost savings/revenue generation that must be addressed before ionic liquid pre‐treatment can compete with other, more established, pre‐treatment technologies. This report evaluates this new pre‐treatment technology through the perspective of a virtual operating biorefinery, and although there are significant challenges that must be addressed, there is a clear path that can enable commercialization of this novel approach. © 2011 Society of Chemical Industry and John Wiley &amp; Sons, Ltd
1H and13C NMR studies of 6,11-dimethyl-6H-indolo[2,3-b] quinoline and some of its derivatives (1995)

The 1H and 13C NMR spectra of the parent 6,11-dimethyl-6H indolo[2,3-b]quinoline and of its nine 2- and 9- methyl-, methoxy- and fluoro-substituted derivatives have been measured and analysed by the use of cosy, HETCOR, SPT INEPT and selective decoupling experiments. The INADEQUATE experiment was applied to yield the one-bond 13C–13C coupling constants for most of the compounds studied. Proton–proton coupling constants including long-range ones have also been determined. Strong concentration effects on the spectra have been observed for all the compounds studied. In particular, large upheld shifts upon the increase of concentration have been observed for some proton resonances. This has been explained in terms of self association of the compounds.
The Disorder of Things (1994)

Essay| April 01 1994 The Disorder of Things: Art Libraries, Postmodernism, and Hypermedia Simon Ford Simon Ford Simon Ford is a curator at the National Art Library, Victoria and Albert Museum, London. Search for other works by this author on: This Site PubMed Google Scholar Afterimage (1994) 21 (9): 10–14. https://doi.org/10.1525/aft.1994.21.9.10 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Simon Ford; The Disorder of Things: Art Libraries, Postmodernism, and Hypermedia. Afterimage 1 April 1994; 21 (9): 10–14. doi: https://doi.org/10.1525/aft.1994.21.9.10 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAfterimage Search This content is only available via PDF. © 1994 by The Regents of the University of California1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis (2004)

Emerging data suggest that metastasis-associated protein 1 (MTA1) represses ligand-dependent transactivation functions of estrogen receptor-alpha in cultured breast cancer cells and that MTA1 is upregulated in human breast tumors. However, the role of MTA1 in tumorigenesis in a physiologically relevant animal system remains unknown. To reveal the role of MTA1 in mammary gland development, transgenic mice expressing MTA1 under the control of the mouse mammary tumor virus promoter long terminal repeat were generated. Unexpectedly, we found that mammary glands of these virgin transgenic mice exhibited extensive side branching and precocious differentiation because of increased proliferation of ductal and alveolar epithelial cells. Mammary glands of virgin transgenic mice resemble those from wild-type mice in mid-pregnancy and inappropriately express beta-casein, cyclin D1 and beta-catenin protein. Increased ductal growth was also observed in the glands of ovariectomized female mice, as well as of transgenic male mice. MTA1 dysregulation in mammary epithelium and cancer cells triggered downregulation of the progesterone receptor-B isoform and upregulation of the progesterone receptor-A isoform, resulting in an imbalance in the native ratio of progesterone receptor A and B isoforms. MTA1 transgene also increased the expression of progesterone receptor-A target genes Bcl-XL (Bcl2l1) and cyclin D1 in mammary gland of virgin mice, and, subsequently, produced a delayed involution. Remarkably, 30% of MTA1 transgenic females developed focal hyperplastic nodules, and about 7% exhibited mammary tumors within 18 months. These studies establish, for the first time, a potential role of MTA1 in mammary gland development and tumorigenesis. The underlying mechanism involves the upregulation of progesterone receptor A and its targets, Bcl-XL and cyclin D1.
Formation d'ingénieur en Hydraulique et Mécanique des fluides : exemple de l'enseignement à l'Ecole Nationale des Ponts et Chaussées (1991)

The present paper deals with the complement aspects of , which results from the increasing use of the general Fluid Mechanics methods white solving Hydraulics problems. The paper emphasizes how these complementary aspects are used in the various subtopics of the Applied Fluid Mechanics course at "Ecole Nationale des Ponts et Chaussées".
Application of phase shifting electronic speckle pattern interferometry in studies of photoinduced shrinkage of photopolymer layers (2017)

Photoinduced shrinkage occurring in photopolymer layers during holographic recording was determined by phase shifting electronic speckle pattern interferometry. Phase maps were calculated from the changes in intensity at each pixel due to the phase differences introduced between object and reference beams. Shrinkage was then obtained from the changes in phase as recording proceeded. The technique allows for whole field measurement of the dimensional changes in photopolymers during holographic recording.
Grain dusts and grain plant components vary in their ability to recruit neutrophils (1995)

Occupational exposure to grain dusts can cause bronchitis, particularly to grain sorghum dust. Bronchitis is associated with the presence of increased numbers of neutrophils. To determine how grain dusts could cause neutrophil recruitment to the airways, extract of whole-grain sorghum, corn, and soybean dusts and of pulverized components of these plants were made with Hanks balanced salt solution (HBSS) and used in direct neutrophil chemotaxis experiments. The glume of the grain sorghum plant, the structure holding the seeds in place, caused the migration of the greatest number of neutrophils compared to HBSS [132 +/- 7 vs. 60 cells/high-power field (hpf) +/- 2 SEM, p < .001], followed by whole-grain sorghum dust (121 +/- 5 cells/hpf). Next, bovine bronchial epithelial cells (BBECs) were obtained from fresh lungs and grown to near confluence before challenge with a 10% solution of grain dust and grain plant extracts. The grain sorghum glume and whole-grain sorghum dusts caused release of the greatest amount of neutrophil chemotactic activity (NCA) from BBECs compared to the medium M199 negative control (141 +/- 6 and 153 +/- 7, respectively, vs. 64 cells/hpf +/- 3 SEM, p < .001). The ability to cause neutrophils to migrate by direct and indirect means did not correlate with levels in the grain dusts of endotoxin, which is known to cause release of NCA from bronchial epithelial cells. Therefore, this article describes additional mechanisms by which grain dusts can cause pulmonary inflammation and that are independent of endotoxin levels.
The Need for Precise and Efficient Memory Capacity Budgeting (2020)

Modern high performance computing (HPC) systems pack hundreds of CPU cores to enable extreme parallelism. However, with increasing core counts, the effective per-core memory capacity is reducing. Reducing performance bottlenecks require precise monitoring and budgeting of application memory capacity requirements for attaining high performance, maximum resource efficiency, and low performance variability. Unfortunately, current operating systems (OS) and their toolsets are inaccurate, lack the capability to precisely measure the memory requirements of applications, forcing system administrators to either underestimate or over-provision memory, consequently compromising performance or resource efficiency, respectively.