MP93-10 URINARY, BOWEL, AND SEXUAL FUNCTION AT 2 YEARS FOLLOWING MANAGEMENT OF LOCALIZED PROSTATE CANCER (2017)

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy VII1 Apr 2017MP93-10 URINARY, BOWEL, AND SEXUAL FUNCTION AT 2 YEARS FOLLOWING MANAGEMENT OF LOCALIZED PROSTATE CANCER Shree Agrawal, Anna Zampini, Bradley Gill, Sudhir Isharwal, Joseph Zabell, Yaw Nyame, JJ Haijing Zhang, Eric Klein, and Andrew J Stephenson Shree AgrawalShree Agrawal More articles by this author , Anna ZampiniAnna Zampini More articles by this author , Bradley GillBradley Gill More articles by this author , Sudhir IsharwalSudhir Isharwal More articles by this author , Joseph ZabellJoseph Zabell More articles by this author , Yaw NyameYaw Nyame More articles by this author , JJ Haijing ZhangJJ Haijing Zhang More articles by this author , Eric KleinEric Klein More articles by this author , and Andrew J StephensonAndrew J Stephenson More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2892AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Given the various treatment options available to men diagnosed with prostate cancer, optimal urinary, sexual, and bowel function should be goals of care in addition to disease free survival. This study assesses factors including management decision for localized prostate cancer and their association with urinary, bowel, and sexual function at 2 years following definitive procedural treatment (radical prostatectomy (RP) or brachytherapy (BT)) or active surveillance (AS). METHODS An institutional review of 572 patients who underwent definitive procedural treatment or AS and completed a validated Prostate Health Related Quality of Life Questionnaire at both the time of treatment selection and at 2 year follow-up. Urinary, sexual, and bowel function at 2 years were assessed by self-reported responses to 3 separate questions asking, “Overall, how big a problem has your urinary/sexual/bowel function been for you during the last 4 weeks?” Patient and disease characteristics, baseline urinary, sexual and bowel function, and management selection were analyzed on multivariable logistic regression models for 2 year function outcomes. RESULTS The median age in this cohort was 62 years (IQR: 57-68) with 109 (19%) patients who elected BT, 102 (18%) participated in AS, and 361 (63%) received RP. On multivariable logistic regression for urine function at 2 years, BT vs. AS (HR: 5.4, p = 0.011) and RP vs. AS (HR: 4.0, p = 0.026) associated with worse urinary function. Presence of a partner was associated with better preservation of sexual function (HR: 0.4, p = 0.009), while RP vs. AS (HR: 2.2, p = 0.013) was associated with worse sexual function at 2 years. Significant baseline bowel bother associated with worse bowel function at 2 years (HR: 11.7, p <0.0001); however, type of management was not significantly associated with adverse bowel function. CONCLUSIONS The 2 year urinary, sexual and bowel functions among patients managed for localized prostate cancer are based on multiple patient characteristics in addition to the shared decision for BT, RP or AS. Additional studies should examine matched function outcomes among men managed for localized prostate cancer. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1240 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Shree Agrawal More articles by this author Anna Zampini More articles by this author Bradley Gill More articles by this author Sudhir Isharwal More articles by this author Joseph Zabell More articles by this author Yaw Nyame More articles by this author JJ Haijing Zhang More articles by this author Eric Klein More articles by this author Andrew J Stephenson More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...