gebhart/patrepeval huggingface dataset:
Electrodynamic Pressure Modulation of Protein Stability in Cosolvents (2013)

Cosolvents affect structural stability of proteins in aqueous solutions. A clear understanding of the mechanism by which cosolvents impact protein stability is critical to understanding protein folding in a biological milieu. In this study, we investigated the Lifshitz-van der Waals dispersion interaction of seven different solutes with nine globular proteins and report that in an aqueous medium the structure-stabilizing solutes exert a positive electrodynamic pressure, whereas the structure-destabilizing solutes exert a negative electrodynamic pressure on the proteins. The net increase in the thermal denaturation temperature (ΔTd) of a protein in 1 M solution of various solutes was linearly related to the electrodynamic pressure (PvdW) between the solutes and the protein. The slope of the PvdW versus ΔTd plots was protein-dependent. However, we find a positive linear relationship (r(2) = 0.79) between the slope (i.e., d(ΔTd)/dPvdW) and the adiabatic compressibility (βs) of the proteins. Together, these results clearly indicate that the Lifshitz's dispersion forces are inextricably involved in solute-induced stabilization/destabilization of globular proteins. The positive and/or negative electrodynamic pressure generated by the solute-protein interaction across the water medium seems to be the fundamental mechanism by which solutes affect protein stability. This is at variance with the existing preferential hydration concept. The implication of these results is significant in the sense that, in addition to the hydrophobic effect that drives protein folding, the electrodynamic forces between the proteins and solutes in the biological milieu also might play a role in the folding process as well as in the stability of the folded state.
A population study of the pharmacokinetics of felodipine. (1991)

1. The pharmacokinetics of felodipine was studied after continuous oral administration of 5 or 10 mg conventional tablets to a population of 140 male and female Caucasian subjects, of which 67 were hypertensive patients and 73 were healthy volunteers. In addition, 42 of these individuals received felodipine intravenously. 2. With increasing age the area under the felodipine plasma concentration vs time curve (AUC), the maximum plasma concentration (Cmax), and the terminal elimination half-life of felodipine increased, while the plasma clearance of felodipine decreased. The bioavailability and steady state volume of distribution and the time to Cmax were not consistently influenced by age. 3. The ratio of the AUC of the primary pyridine metabolite of felodipine and that of unchanged drug decreased with increasing age. 4. Neither Cmax, AUC nor the half-life of felodipine were related to body mass index. 5. The distribution of AUC for felodipine, as well as the ratio of the AUC of this first metabolite to that of unchanged felodipine, was unimodal. Thus, the presence of a sizable group of individuals, with a clinically significant different metabolism of 1,4-dihydropyridine due to genetic factors is unlikely. 6. The pharmacokinetics of felodipine did not seem to differ between hypertensive patients and healthy volunteers, when adjusted for age. Neither was there a difference between patients taking beta-adrenoceptor antagonists and those who did not. 7. As a group the elderly had higher total concentrations of unchanged felodipine in plasma compared with younger individuals. The variation in plasma concentrations of felodipine between individuals is, however, only partially explained by age. In clinical practice this emphasizes the need for dose titration of felodipine.
Corot Telescope: COROTEL (2007)

The space Corot telescope has been developed by Thales Alenia Space Cannes (previously named Alcatel Alenia Space) and has been delivered to the French Space agency (CNES. The satelllite has veen successfully launched from Baïkonour the 27th of December 2006. This telescope is a very precise and stable imaging instrument that is pointed towards fixed areas in the sky for periods of at least 5 month, in order to carry out two kinds of missions: (i) Stellar seismology, (ii) Search for exoplanets (by transit detection). Corot is likely to be the first space instrument capable of detecting Earth like planets orbiting around other stars and providing accurate stellar data in relation with their internal constitution. The target stars will have visible magnitudes lower than 9 for the seismology mission, and lower than 13 for the detection of Earth-like planets. COROT is a low cost mission and has a polar circular orbit with an altitude around 800 Km (unfortunately not at L2 orbit). In order to comply with the above objectives, the instrument shall deliver a very stable signal from a stable source. More particularly, this stringent stability requirement implies: (i) a high level of straylight (coming from earth) rejection, (ii) a high pointing stability, (iii) a high level of performance for the thermal control subsystem in term of temperature and gradient stability associated with the use of hyper stable materials. On the other hand, this instrument is carried by a low size satellite associated with the use of hyper stable materials. On the other hand, this instrument is carried by a low size satellite of the PROTEUS family, allowing a faster and cheaper development. This paper focuses on the proposed opto mechanical design for the telescope, its baffling cancept and its performance which are now demonstrated in flight.
CARLOS: an automated multilevel logic design system for CMOS semi-custom integrated circuits (1988)

CARLOS, a program system for the automated synthesis of random combinational CMOS logic, is described. The input of CARLOS is a specification of a multiple-output Boolean function in the form of a truth table. CARLOS produces an optimized random logic circuit composed of NAND, NOR, and complex gates under the given fan-in and fan-out limitations. The algorithms implemented in CARLOS are based on logic minimization, novel multiple-output multilevel factoring strategies, and recursive technology mapping. The factorization algorithm performs multiple-output synthesis using an algebraic representation of multiple-output Boolean functions. Tests on a large set of examples have shown the efficiency of the synthesis in terms of circuit size as well as computation time. CARLOS is an integral part of a larger CAD system that supports the automatic logic and physical design of finite-state machines under gate-array constraints.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
3D shape shearography with integrated structured light projection for strain inspection of curved objects (2015)

Shearography (speckle pattern shearing interferometry) is a non-destructive testing technique that provides full-field surface strain characterization. Although real-life objects especially in aerospace, transport or cultural heritage are not flat (e.g. aircraft leading edges or sculptures), their inspection with shearography is of interest for both hidden defect detection and material characterization. Accurate strain measuring of a highly curved or free form surface needs to be performed by combining inline object shape measuring and processing of shearography data in 3D. Previous research has not provided a general solution. This research is devoted to the practical questions of 3D shape shearography system development for surface strain characterization of curved objects. The complete procedure of calibration and data processing of a 3D shape shearography system with integrated structured light projector is presented. This includes an estimation of the actual shear distance and a sensitivity matrix correction within the system field of view. For the experimental part a 3D shape shearography system prototype was developed. It employs three spatially-distributed shearing cameras, with Michelson interferometers acting as the shearing devices, one illumination laser source and a structured light projector. The developed system performance was evaluated with a previously reported cylinder specimen (length 400 mm, external diameter 190 mmm) loaded by internal pressure. Further steps for the 3D shape shearography prototype and the technique development are also proposed.
Inhibition of Candida albicans yeast–hyphal transition and biofilm formation by Solidago virgaurea water extracts (2012)

Xerostomia is a decrease of saliva secretion, which can unbalance the oral microflora, mainly to the benefit of Candida albicans. The aim of the present study was to find a plant extract that could create an unfavourable environment for Candida, and would, therefore, be appropriate for use in a dry-mouth daily-care mouthwash. Water extract from the herbaceous plant Solidago virgaurea (Goldenrod) was selected due to its saponin content (plant detergents). Saponin concentrations reached 0.7 and 0.95 mg ml(-1) in S. virgaurea subsp. virgaurea and S. virgaurea subsp. alpestris extracts, respectively. C. albicans was grown in liquid medium and cells were counted by microscopic examination after 0, 4 and 24 h of incubation. Solidago extracts did not inhibit the growth of C. albicans (four strains), Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans, Streptococcus salivarius or Enterococcus faecalis. When inocula were incubated with Solidago extract for 4 and 24 h, we observed a decrease in Candida yeast-hyphal transition. Candida biofilms were then prepared in microtitre plates and treated with plant extracts at 0 h, to estimate biofilm formation, or at 18 h to estimate the effect of the saponin on pre-formed biofilms. Biofilm formation and pre-formed biofilms were both strongly inhibited. In conclusion, the S. virgaurea extract was efficient against two key virulence factors of C. albicans: the yeast-hyphal transition phase and biofilm formation.
Abstract 115: Primary Hyperadrenergic Postural Tachycardia Syndrome. Evidence From Sympathetic Nerve Recordings (2017)

Postural tachycardia syndrome (POTS) is a chronic disabling condition with excessive upright tachycardia and symptoms due to enhanced sympathetic activity in otherwise healthy young individuals. Because it is not clear if sympathetic activation is a primary phenomenon, or an appropriate compensatory response to hypovolemia, deconditioning or partial neuropathy, we analyzed resting supine muscle sympathetic nerve activity (MSNA) in 38 female POTS patients (mean±SD, age 32.1±9.1, BMI 22.7±5.4). MSNA showed a wide range of burst rate (19.7±12.1 bursts/min, range 1.2 to 54, 95% CI: 15.7 to 23.6). We compared the 1 st and 4 th Quartiles of 28 MSNA records (MSNA_Q1: &lt; 7.3; MSNA_Q4: &gt; 23.4 bursts/min) to determine if resting MSNA is related to heart rate (HR) or blood pressure (BP) responses to orthostatic challenge and the Valsalva maneuver (2-way ANOVA with post-hoc tests). Upright HR was inappropriately high in both groups (MSNA_Q1: 120±19 vs. MSNA_Q4: 110±20 bpm, NS), but the MSNA_Q4 group had higher upright diastolic BP than MSNA_Q1 (81±12 vs. 62±8 mmHg, P&lt;0.01). Similarly, there were no differences in HR response to the Valsalva maneuver between groups, but systolic and diastolic BP were higher during late phase 2 in MSNA_Q4 (p&lt;0.05), and this was preceded by higher MSNA spike rate (44.3±16.3 vs. 81.2 ±25 maximal spikes/secs per beat, p&lt;0.01) during early phase 2 of Valsalva maneuver. The greater BP responses, but comparable HR responses, to posture and Valsalva challenges provide evidence that the subset of POTS patients with higher resting MSNA have a primary sympathetic activation. These patients might benefit from sympatholytic therapy in contrast to other POTS patients with low or absent resting MSNA.
Measurement of pion enhancement at low transverse momentum and of the Δ resonance abundance in Si-nucleus collisions at AGS energy (1995)

We present measurements of pion transverse momentum (pt) spectra in central Si-nucleus collisions in the rapidity range 2.0 < y < 5.0 for pt down to and including pt = 0. The data exhibit an enhanced pion yield at low pt compared to what is expected for a purely thermal spectral shape. This enhancement is used to determine the Δ resonance abundance at freeze-out. The results are consistent with a direct measurement of the Δ resonance yield by reconstruction of proton-pion pairs and imply a temperature of the system at freeze-out close to 140 MeV.
Figure S9 from MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors (2023)

&lt;p&gt;Supplemental Fig.S9. Synergy of TYK2 and MEK inhibitors in MPNST-724 cells.&lt;/p&gt;
A Mean Field Based Methodology for Modeling Mobility in Ad Hoc Networks (2011)

In this paper we propose a methodology for the modeling and analysis of ad hoc networks composed by a large number of nodes moving among geographical regions. This methodology uses compositional construction of stochastic Petri nets (SPN) for building the model which allows for specifying the model and the required performance indices at a high level of abstraction. As our aim is to consider real scenarios with several geographical regions and non-trivial user behavior in each region, the size of the state space of the model can easily grow too large to analyze with exact analytical approaches or even with simulation. For this reason, we propose to carry out the analysis by constructing the mean field approximation of the behavior of the SPN. The approximation is provided by a set of ordinary differential equations (ODE) that can be derived automatically from the SPN and can be solved numerically with low computational effort even for large models. The methodology is illustrated on a case study, modeling application spreading in a mobile environment. It will be shown that the approximate results obtained by the mean field approach capture well the behavior of the system.
Analysis of the main factors influencing the energy consumption of electric vehicles (2013)

Electric vehicles are currently a held of research with many challenges that raise the interest of many researchers. The major challenge is about the autonomy of electric vehicles, which is limited as compared to that of conventional vehicles, and thus the drivers' anxiety about reaching or not the desired destination is very important. In this paper, we propose an experimental study to understand the energy consumption of electric vehicles, and we investigate some factors that have an important impact on their autonomy, such as the route type, the driving style and the ambient temperature. This study can be very useful in a further step to conceive a driving assistance system that indicates in real time the remaining energy and gives online instructions to reach the next charging station or the final destination. The analysis reported in this paper is based on real-world data collected using a full electric car with different driving conditions.
Association of Burkitt's Lymphoma with the Epstein-Barr Virus in Two Developing Countries (2000)

The clinical presentation of Burkitt's lymphoma (BL) and it's association with the Epstein-Barr virus (EBV) varies in different geographic areas, BL in developing countries being "intermediate" between the sporadic and endemic types, both in it's clinical presentation and it's association with EBV, which varies from 25-80%. In this study we have analysed the clinical features, EBV association, subtype and prevalence of the deleted variant of the Latent Membrane Protein-1 (LMP-1) of EBV in forty-two cases from two developing countries- India (n = 25) and Argentina (n = 17). In both countries the abdomen was the site most commonly involved while jaw involvement was rare. EBV was detected by in-situ hybridization using the EBER-1 RNA probe. 47% of cases from Argentina and 80% of cases from India were EBER positive. EBV typing using EBNA-3C primers showed a predominance of Type A in both countries (India-13/16 and Argentina-(7/8)). The 30bp deletion of the LMP-1 gene was detected in all evaluated cases from Argentina while the wild type of the gene was seen in all the evaluable Indian cases. Our study highlights the similarities and differences in the clinical presentation and EBV association of BL in two developing countries and also indicates that the subtype of EBV and prevalence of the LMP-1 deletion may reflect the predominant subtype in a particular population.
YplA Is Exported by the Ysc, Ysa, and Flagellar Type III Secretion Systems ofYersinia enterocolitica (2002)

Yersinia enterocolitica maintains three different pathways for type III protein secretion. Each pathway requires the activity of a specific multicomponent apparatus or type III secretion system (TTSS). Two of the TTSSs are categorized as contact-dependent systems which have been shown in a number of different symbiotic and pathogenic bacteria to influence interactions with host organisms by targeting effector proteins into the cytosol of eukaryotic cells. The third TTSS is required for the assembly of flagella and the secretion of the phospholipase YplA, which has been implicated in Y. enterocolitica virulence. In this study, YplA was expressed from a constitutive promoter in strains that contained only a single TTSS. It was determined that each of the three TTSSs is individually sufficient for YplA secretion. Environmental factors such as temperature, calcium availability, and sodium chloride concentration affected the contribution of each system to extracellular protein secretion and, under some conditions, more than one TTSS appeared to operate simultaneously. This suggests that some proteins might normally be exported by more than one TTSS in Y. enterocolitca.
Effect of uni-axial strain on THz/far-infrared response of graphene (2012)

We present polarized optical transmission study of uniaxially strained large scale graphene in THz/far-infrared (IR) frequency region. Graphene was supported on stretchable polyethylene substrate and they were elongated up to 20% (ΔL/Lo = 0.2) by applying tensile force. For the IR light polarized along the strain direction (EIR//strain), the optical conductivity σ1(ω) of graphene changes from Drude response into strongly non-Drude-like behavior with a peak formed at finite energy ∼10 meV. In contrast, the coherent Drude conductivity is preserved along the direction perpendicular to the strain (EIR⊥strain). Possible origin of the strain-induced non-Drude σ1(ω)-behavior is discussed.
Derecho privado romano (2011)

La experiencia iusprivatistica romana constituye una manifestacion clasica de la ciencia del derecho, que trasciende el periodo de tiempo en que se produce, para conformar el pilar basico sobre el que se asienta el derecho privado continental europeo. La mayoria de los conceptos, instituciones, reglas y soluciones a las cuestiones, asi como la sistematica que informa el actual ordenamiento juridico, en materia de derecho privado, tienen su origen en el Derecho romano. Roma inventa el Derecho en Occidente, y ensambla por vez primera, en expresion orteguiana, el oriente y el occidente de Europa.

El derecho romano constituye la experiencia juridica mas paradigmatica de la historia europea. La ensenanza del Digesto Justinianeo en la Bolonia del siglo XI, esta en el origen de la que fue la primera universidad europea y constituye, desde entonces, a la conformacion de la logica juridica de los estudiantes de las Facultades de Derecho.

El estudio del derecho privado romano, constituye no solo un elemento indispensable para valorar la historicidad del Derecho, sino que tambien se configura como un instrumento necesario para entender el derecho vigente y para ayudar a la construccion, sobre los elementos comunes que el Derecho romano proporciona a los Codigos civiles europeos, del derecho privado de la Union Europea, que el irreversible proceso unificador nos deparara en el futuro.

El Autor del presente Manual, es Catedratico de Derecho Romano de la Universidad Autonoma de Madrid y, ha intentado conectar, desde el analisis de la realidad historica, el Derecho romano con el vigente derecho civil espanol, en el convencimiento de que un numero importante de articulos de este cuerpo legal, paradigma legislativo, constituyen el ultimo eslabon de la evolucion del pensamiento juridico desde Roma hasta el actual derecho positivo.

La novedad de esta cuarta edicion esta constituida por la incorporacion de la parte correspondiente al derecho de obligaciones, con la correspondiente actualizacion de la bibliografia y del indice analitico, que se adiciona al estudio del derecho procesal, el derecho de la persona, el derecho de familia, el negocio juridico, y los derechos reales, ya abordados en la anterior edicion.
An optical narrow-band filter based on a Bragg grating recorded in a microchannel waveguide filled with a photopolymer (2013)

The problem of creating a narrow-band filter that operates with wide-aperture (about 30°) light beams is solved in this paper. It describes the search for and the experimental certification of methods of creating a single-mode lightguide with a Bragg grating in it. An optical narrow-band filter is obtained by forming a Bragg grating in the microchannels of a fiber filled with a photopolymer. The proposed technology for filling the fiber ensures homogeneous filling of microchannels longer than 20 mm. The photopolymer composite thus developed makes it possible to obtain the photoinduced refractive-index modulation needed to record a grating in a solid composite. Such recording ensures that it is stable. The resulting temperature-stable filter can be used for spectral filtering of wide-aperture (about 30°) light beams.
Nonlinear McKean-Vlasov diffusions under the weak Hormander condition with quantile-dependent coefficients (2021)

In this paper, the strong existence and uniqueness for a degenerate finite system of quantile-dependent McKean-Vlasov stochastic differential equations are obtained under a weak Hörmander condition. The approach relies on the apriori bounds for the density of the solution to time inhomogeneous diffusions. The time inhomogeneous Feynman-Fac formula is used to construct a contraction map for this degenerate system.
Lithoprobe seismic reflection profiling across Vancouver Island: results from reprocessing (1987)

Multichannel seismic reflection sections recorded across Vancouver Island have revealed two extensive zones of deep seismic reflections that dip gently to the northeast, and a number of moderate northeasterly dipping reflections that can be traced to the surface where major faults are exposed. Based on an integrated interpretation of these data with information from gravity, heat flow, seismicity, seismic refraction, magnetotelluric and geological studies it is concluded that the lower zone of gently dipping reflections is due to underplated oceanic sediments and igneous rocks associated with the current subduction of the Juan de Fuca plate, and that the upper zone represents a similar sequence of accreted rocks associated with an earlier episode of subduction. The high density/high velocity material between the two reflection zones is either an underplated slab of oceanic lithosphere or an imbricated package of mafic rocks. Reprocessing of data from two of the seismic lines has produced a remarkable image of the terrane bounding Leech River fault, with its dip undulating from >60° near the surface to 20° at 3 km depth and ˜38° at 6 km depth.