gebhart/patrepeval huggingface dataset:
Latency Analysis of Flexible Redundant Scheme in MDS-Coded Distributed Storage Systems (2017)

Access latency is the bottle-neck of various web services, and can greatly impact user experience, especially for the data retrieval applications, such as Google search. Many large-scale distributed storage systems are moving to the use of erasure codes to provide low storage overhead and high failure tolerance. Most previous work about coding latency focuses on the case when users desire all the data in a codeword. However, we find that in practical MDS- coded storage systems, the size of a codeword is usually so big that users only desire part of the files in a codeword. Hence, it is significant to analyze the latency in coding systems when users only desire part of a codeword. In this paper, we propose Flexible Redundant Scheme (FRedS) that can deal with the general case in which users only require part of the files from a codeword. In the case of no queueing delay, we give a general and closed-form expression of the coding latency with FRedS. Considering queueing delay, we extend the popular latency bound to analyze the latency performance of FRedS under the general service time distribution. Through extensive simulations using real service time traces from Amazon S3, we validate our latency analysis, demonstrate the tightness of the bounds derived in this work and show the latency comparison of FRedS and the direct read scheme.
Expression of Wnt, Frizzled, sFRP, and DKK Genes in Adult Human Pancreas (2003)

Wnts are important signaling molecules involved in many normal developmental processes in the human body as well as some forms of cancer. Nineteen Wnt genes are found in the human genome, as well as 10 Wnt receptor genes called Frizzled. Two coreceptors called LRP 5 and 6 are critical for Wnt signal transduction. The interaction of the Wnts with the receptors is regulated by two classes of extracellular Wnt or LRP binding proteins called sFRP and Dickkopf (DKK), which modulate Wnt signaling. We have examined the expression of all Wnt family members both in the exocrine portion and in isolated islets of adult human pancreas. RT-PCR analysis of the 1-day cultured exocrine pellet fraction from the islet isolation procedure showed that Wnt 2, 2b, 3, 4, 5a, 5b, 7a, 7b, 14, and 15 were detectable. All 10 Frizzled (Frz) receptors were expressed but only Frizzled 1, 2, 4, 5, and 6 strongly. RT-PCR performed on purified human islets revealed that Wnt 2b, 3, 4, 5a, 7b, 10a, and 14 and Frz 4, 5, and 6 were the most highly expressed. DKK 1, 3, and 4 as well as sFRP 1, 4, and 5 were expressed in the exocrine fraction. sFRP 2 and 3 were detectable but only at low levels. In situ hybridization for Frz 1-7 showed that expression colocalized with the islets of Langerhans. Together the data suggest that active Wnt signaling occurs in adult pancreas and is probably important for physiological functions.
Benomyl and Colchicine Synergistically Inhibit Cell Proliferation and Mitosis: Evidence of Distinct Binding Sites for These Agents in Tubulin (2008)

Benomyl, a tubulin-targeted antimitotic antifungal agent, belongs to the benzimidazole group of compounds, which are known to inhibit the binding of colchicine to tubulin. Therefore, benomyl was thought to bind at or near the colchicine-binding site on tubulin. However, recent mutational studies in yeast and fluorescence studies involving competitive binding of benomyl and colchicine on goat brain tubulin suggested that benomyl may bind to tubulin at a site distinct from the colchicine-binding site. We set out to examine whether colchicine and benomyl bind to tubulin at distinct sites using a human cervical cancer (HeLa) cell line with the thinking that these agents should exert either additive or synergistic activity on cell proliferation if their binding sites on tubulin are different. We found that benomyl and colchicine synergistically inhibited the proliferation of HeLa cells and blocked their cell cycle progression at mitosis. The synergistic activity of benomyl and colchicine was also apparent from their strong depolymerizing effects on both the spindle and interphase microtubules when used in combinations, providing further evidence that these agents bind to tubulin at different sites. Using NMR spectroscopy, we finally demonstrated that benomyl and colchicine bind to tubulin at different sites and that the binding of colchicine seems to positively influence the binding of benomyl to tubulin and vice versa. Further, an analysis of the saturation transfer difference NMR data yielded an interesting insight into the colchicine-tubulin interaction. The data presented in this study provided a mechanistic understanding of the synergistic effects of benomyl and colchicine on HeLa cell proliferation.
A New Chiral Stationary Phase Bearing Both π-Acidic and π-Basic Sites Derived from (S)-Tyrosine for the Liquid Chromatographic Resolution of Racemates (1994)

Abstract A new chiral stationary phase (CSP) bearing both π-acidic and π-basic sites for the chiral liquid chromatography has been prepared from (S)-tyrosine. This CSP has been found to be useful in resolving a variety of either π-basic or π-acidic racemates.
Identification and Quantification of Flavonol Glycosides in Almond Seedcoats Using MALDI-TOF MS (2002)

Interest in the molecular composition of almonds is growing, due to their popularity in a wide variety of food formulations. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a powerful new technique that can be used to rapidly identify and quantify possible bioactive compounds in these popular tree nuts. Four flavonol glycosides were identified in almond seedcoats for the first time: isorhamnetin rutinoside, isorhamnetin glucoside, kaempferol rutinoside, and kaempferol glucoside. A MALDI-TOF MS methodology was developed using rutin (quercetin-3-rutinoside) as an internal standard to quantitatively determine each of the four flavonol glycosides. Results of MALDI-TOF MS analysis were verified by high performance liquid chromatography.
Area-efficient convolutional deinterleaver for mobile TV receiver (2013)

In this article, a single-pointer structure is proposed for the convolutional deinterleavers of mobile TV receivers. To enhance the burst-error correcting capability, the convolutional interleaving and deinterleaving scheme is widely used in mobile TV receivers. However, a convolutional deinterleaver requires many pointer registers. This article introduces a single-pointer structure that reduces the number of pointer registers. Experimental results show that the single-pointer structure reduces the area of the convolutional deinterleaver by 70% in a mobile TV receiver.
Finding My Way in African Women’s History (2018)

This chapter describes Kathleen Sheldon’s introduction to African women’s history, focusing on the two years she lived in Mozambique in the early 1980s, doing research on working women under a newly independent socialist government. An internal war was developing at the time, adding obstacles to her research and to life in general. She developed her own sources for that history by interviewing women in garment and cashew factories, as well as nurses. On her return, she was able to continue her research and writing as an independent scholar with the support of the Prelinger Award, feminist historians at UCLA, and in African studies.
MO-FG-BRC-04: Ionacoustic Imaging for Particle Range Verification (2016)

Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices. From Canada, we will learn about novel linear accelerator target design and the implications for imaging and therapy. From France, we will discover a mature translational effort to incorporate theranostic nanoparticles in MR-guided radiation therapy. From Germany, we will find out about a novel in-treatment imaging modality for particle therapy. These examples of high impact, experimental medical physics research are representative of the diversity of such efforts that are on-going around the globe. J. Robar, Research is supported through collaboration with Varian Medical Systems and Brainlab AGD. Westerly, This work is supported by the Department of Radiation Oncology at the University of Colorado School of Medicine. COI: NONEK. Parodi, Part of the presented work is supported by the DFG (German Research Foundation) Cluster of Excellence MAP (Munich-Centre for Advanced Photonics) and has been carried out in collaboration with IBA.
Adsorption of Chromate and Arsenate by Amino-Functionalized MCM-41 and SBA-1 (2002)

We report the characteristics of aminosilane-grafted mesoporous silicas as adsorbents of oxyanions in acidic conditions. Mono-, di-, and triamino-functionalized silicas were prepared to examine the influence of amino group density. The triaminosilane-grafted mesoporous silica adsorbed more chromate and arsenate than expected from the increased number of sites, suggesting stable complex formations. Functionalized SBA-1 showed larger adsorption capacities than MCM-41 derivatives. The adsorption capacity was independent of the average surface density of monoamino groups, demonstrating domain formation of fixed silanes. These structural characteristics on molecular and meso scales may offer insights into understanding the mechanism of heterogeneous oxyanion capture by amino-functionalized solids, which are promising inexpensive reagents for reducing toxic anion pollution.
Histon-Deacetylierung als Regulator des humanen E-Cadherin Promotors im Pankreaskarzinom (2007)

Einleitung: E-Cadherin ist ein wichtiges Zell-Adhäsionsmolekül und sein Verlust ist mit aggressivem Wachstum und rascher Metastasierung vieler Tumoren, unter anderem des Pankreaskarzinoms, assoziiert. Ein Verlust der E-Cadherin Expression kann Folge von somatischen Mutationen sein, jedoch scheinen auch epigenetische Mechanismen eine Rolle bei der Inhibition zu spielen.
Evaluating User Perspectives of Audio Fingerprinting Technologies (2019)

Audio fingerprinting, the process by which an audio sample is automatically identified or categorized based on its unique analog properties, is a technology that has been integrated quite rapidly into commercial and consumer music applications. Although academic literature has covered specific algorithms, technical specifications of prototype applications, and practical implementations of audio fingerprinting software, little attention has been given to public opinions. However, public opinion has been debated extensively in online blogs, forums, newspapers, and e-mail lists. This study addresses this knowledge gap by examining a sample, via content analysis, of 30 web-based resources, revealing public opinions about this topic. The sample was drawn from alternative resources, as they provide a rich information source for understanding public perception and opinion about audio fingerprinting. This paper presents background research and key new findings based on this study. The content analysis identified key concepts and unifying discussion themes. The research approach and analysis was verified by two independent evaluators, confirming consistency in coding. The results revealed significant public interest in topics of audio fingerprinting metadata, and emphasized the following themes as important topics among the public: 1. user interfaces, 2. technical issues, 3. copyright implications, 4. royalties, and 5. user privacy. The paper concludes with a series of recommendations for future research.
Network of Interactions Between Gut Microbiome, Host Biomarkers, and Urine Metabolome in Carotid Atherosclerosis (2021)

Comprehensive analyses of multi-omics data may provide insights into interactions between different biological layers concerning distinct clinical features. We integrated data on the gut microbiota, blood parameters and urine metabolites of treatment-naive individuals presenting a wide range of metabolic disease phenotypes to delineate clinically meaningful associations. Trans-omics correlation networks revealed that candidate gut microbial biomarkers and urine metabolite feature were covaried with distinct clinical phenotypes. Integration of the gut microbiome, the urine metabolome and the phenome revealed that variations in one of these three systems correlated with changes in the other two. In a specific note about clinical parameters of liver function, we identified Eubacteriumeligens, Faecalibacteriumprausnitzii and Ruminococcuslactaris to be associated with a healthy liver function, whereas Clostridium bolteae, Tyzzerellanexills, Ruminococcusgnavus, Blautiahansenii, and Atopobiumparvulum were associated with blood biomarkers for liver diseases. Variations in these microbiota features paralleled changes in specific urine metabolites. Network modeling yielded two core clusters including one large gut microbe-urine metabolite close-knit cluster and one triangular cluster composed of a gut microbe-blood-urine network, demonstrating close inter-system crosstalk especially between the gut microbiome and the urine metabolome. Distinct clinical phenotypes are manifested in both the gut microbiome and the urine metabolome, and inter-domain connectivity takes the form of high-dimensional networks. Such networks may further our understanding of complex biological systems, and may provide a basis for identifying biomarkers for diseases. Deciphering the complexity of human physiology and disease requires a holistic and trans-omics approach integrating multi-layer data sets, including the gut microbiome and profiles of biological fluids. By studying the gut microbiome on carotid atherosclerosis, we identified microbial features associated with clinical parameters, and we observed that groups of urine metabolites correlated with groups of clinical parameters. Combining the three data sets, we revealed correlations of entities across the three systems, suggesting that physiological changes are reflected in each of the omics. Our findings provided insights into the interactive network between the gut microbiome, blood clinical parameters and the urine metabolome concerning physiological variations, and showed the promise of trans-omics study for biomarker discovery.
A Pulsed System for Obtaining Microdosimetric Data with High Intensity Beams (1978)

The use of heavy particle accelerators for radiation therapy requires high intensity beams in order to produce useful dose rates. The 800-MeV proton beam at LAMPF passes through different production targets to generate secondary pion beams. Conventional microdosimetric techniques are not applicable under these conditions because exceedingly high count rates result in detector damage, gas breakdown, and saturation effects in the electronics. We describe a new microdosimetric system developed at the Pion Biomedical Channel of LAMPF. The accelerator provides a variable low intensity pulse once every ten high intensity macropulses. The voltage on the detector is pulsed in coincidence with the low intensity pulse so that we were able to operate the detector under optimum data-taking conditions. A low noise two-stage preamplifier was built in connection with the pulsed mode operation. A comparison is made between data obtained in pulsed (high intensity beam) and unpulsed (low intensity beam) modes. The spectra obtained by the two methods agree within the experimental uncertainties.
Using transformations to improve semantic matching (2003)

Many AI tasks require determining whether two knowledge representations encode the same knowledge. Solving this matching problem is hard because representations may encode the same content but differ substantially in form. Previous approaches to this problem have used either syntactic measures, such as graph edit distance, or semantic knowledge to determine the "distance" between two representations. Although semantic approaches outperform syntactic ones, previous research has focused primarily on the use of taxonomic knowledge. We show that this is not enough because mismatches between representations go largely unaddressed. In this paper, we describe how transformations can augment existing semantic approaches to further improve matching. We also describe the application of our approach to the task of critiquing military Courses of Action and compare its performance to other leading algorithms.
Enhanced Cyclability of π-π Stacked Supramolecular (1,5-Diaminoanthraquinone) Oligomer as an Electrochemical Capacitor Material (2002)

An oligomeric supramolecule of 1,5-diaminoanthraquinone (DAAQ), having a crystalline structure by π-π interaction, has been proposed as an active material for electrochemical capacitors. By choosing carefully the electro-oxidation conditions, an electroactive supramolecular DAAQ oligomer was obtained as a film, exhibiting a charge density of 50 Ah kg−1. The oligomeric DAAQ film maintained its crystalline structure and showed reproducible redox responses over 20,000 cycles with little capacity loss (5%). Such a good reproducibility of the crystalline DAAQ oligomer was caused by isotropic and small conformational changes during the redox reactions. © 2002 The Electrochemical Society. All rights reserved.
Analysis of Polyacetylenes by HPLC in Hairy Root Cultures of Lobelia inflata Cultivated in Bioreactor (2004)

Lobelia inflato L. contains pharmacologically important secondary\nmetabolites. The main alkaloid is lobeline which has a stimulatory\neffect on the respiratory centre. Recently high quantity of\npolyacetylenes was determined in the plant and hairy root cultures.\nWith the aim of increasing of the secondary metabolite production hairy\nroot cultures were produced (by direct infection of the sterile plants\nwith Agrobacterium rhizogenes strain R1601). A new HPLC method was\ndeveloped for the determination of lobetyolin and lobetyolinin, the\nmain polyacetylene compounds of L. inflata hairy roots. The analysis\nwas performed on Hypersil MOS column (250 x 4 mm I.D.). The mobile\nphase was 15:85 (v/v) mixture of acetonitrile and water. Peaks were\nidentified by addition of standards and by DAD. The external\nstandardized method allowed the determination of lobetyolin and\nlobetyolinin with good sensitivity and reliability. This method was\nused to measure the polyacetylene contents of hairy roots grew\nintensively in bioreactor. High contents of lobetyolin (3.6%) and\nlobetyolinin (0.8-1.6%) were detected in the hairy roots because of\ntheir great biosynthetic capacity.
Femtosecond photoemission study of ultrafast electron dynamics on Cu(100) (1997)

The energy dependence of the relaxation of photoexcited electrons in copper was measured using femtosecond time-resolved photoemission spectroscopy to within 0.3 eV above the Fermi level. By performing lifetime measurements under different surface conditions, several surface dynamical processes were investigated. In particular, an anomalous long lifetime feature, which cannot be explained with Fermi-liquid theory, was observed in the lifetime-energy curve. This feature was found originating from the photoexcitation of the strongly localized Cu $3d$ electrons.
Using Project Management Techniques in Hydro-Relicensing (1991)

To answer a pressing need for managing today's complex process and requirements of hydro relicensing, Central Maine Power Company (CMP) has applied the principles of project management, including the use of computerized scheduling to its hydro relicensing efforts. This approach involves early inter-departmental cooperation in mapping out critical path scheduling by requiring the project team to: 1. Outline the scope of the project in its entirety. 2. Clarify and define components of the project. 3. Quantify and categorize assumptions and dependencies. 4. Identify constraints. The computer-generated schedule of this cooperative planning effort provides a graphic representation of the team's plan and becomes the focal point for refinements and adjustments necessary to complete an application on time. The use of project management techniques facilitates team understanding of the realities and limitations in the relicensing process. These techniques encourage cooperative action toward a common goal, and use a solution-oriented process resulting in a product which can be a useful tool in communicating with resource agencies and regulators.
Spin-singlet wave function for the half-integral quantum Hall effect (1988)

We present an analytic wave function describing a spin-singlet incompressible fluid of electrons confined to a single Landau level, which exhibits a half-integral quantum Hall effect. Our numerical studies suggest that this state may be responsible for the recently observed effect with \ensuremath{\nu}=(5/2. .AE
Protein contact map refinement for improving structure prediction using generative adversarial networks (2021)

Supplementary data are available at Bioinformatics online.
Patient-Controlled Epidural Analgesia or Multimodal Pain Regimen with Periarticular Injection After Total Hip Arthroplasty (2015)

PAI did not decrease the time to discharge and was associated with higher pain scores and greater opioid consumption but lower ORSDS scores compared with PCEA. The choice for analgesic regimen may depend on a particular patient's threshold for pain and the potential side effects.
Assembly, Activation, and Substrate Specificity of Cyclin D1/Cdk2 Complexes (2013)

Previous studies have shown conflicting data regarding cyclin D1/cyclin-dependent kinase 2 (Cdk2) complexes, and considering the widespread overexpression of cyclin D1 in cancer, it is important to fully understand their relevance. While many have shown that cyclin D1 and Cdk2 form active complexes, others have failed to show activity or association. Here, using a novel p21-PCNA fusion protein as well as p21 mutant proteins, we show that p21 is a required scaffolding protein, with cyclin D1 and Cdk2 failing to complex in its absence. These p21/cyclin D1/Cdk2 complexes are active and also bind the trimeric PCNA complex, with each trimer capable of independently binding distinct cyclin/Cdk complexes. We also show that increased p21 levels due to treatment with chemotherapeutic agents result in increased formation and kinase activity of cyclin D1/Cdk2 complexes, and that cyclin D1/Cdk2 complexes are able to phosphorylate a number of substrates in addition to Rb. Nucleophosmin and Cdh1, two proteins important for centrosome replication and implicated in the chromosomal instability of cancer, are shown to be phosphorylated by cyclin D1/Cdk2 complexes. Additionally, polypyrimidine tract binding protein-associated splicing factor (PSF) is identified as a novel Cdk2 substrate, being phosphorylated by Cdk2 complexed with either cyclin E or cyclin D1, and given the many functions of PSF, it could have important implications on cellular activity.