gebhart/patrepeval huggingface dataset:
Use of a PPAR Gamma-Specific Monoclonal Antibody to Demonstrate Thiazolidinediones Induce PPAR Gamma Receptor Expression In Vitro (1999)

Troglitazone and rosiglitazone (BRL49653), members of the thiazolidinedione (TZD) class of antidiabetic drugs, are peroxisome proliferator-activated receptor gamma (PPARgamma) ligands that induce adipocyte differentiation and increase the expression of PPARgamma protein. Here, we report the characterization of a PPARgamma specific monoclonal antibody (MAb), PgammaA53.25, and its use to monitor PPARgamma expression in the noncommitted pluripotent murine mesenchymal stem cell line, C3H10T1/2, treated with TZDs. MAb PgammaA53.25 was raised against a region in the N-terminal domain of human PPARgamma shared by splice variants PPARgamma1 and PPARgamma2. It recognizes immunizing antigen in enzyme-linked immunoadsorbent assay (ELISA), and does not cross-react with the N-terminal domains of PPARalpha or PPARdelta. In Western blotting, PgammaA53.25 reacts with the immunizing antigen as well as distinct protein bands corresponding to the molecular weight of full length PPARgamma from C3H10T1/2 cells and rat tissue lysates. In fluorescent microscopy, PgammaA53.25 immunostains nuclei of C3H10T1/2 cells treated with PPARgamma ligands. The fluorescence intensity of the treated cells is TZD dose-dependent, and correlates with lipid accumulation consistent with adipogenesis. Based on these results, we propose that MAb PgammaA53.25 will be a useful tool for elucidating the role of PPARgamma in fatty acid metabolism and adipocyte differentiation.
Guided photoluminescence study of Nd-doped silicon rich silicon oxide and silicon rich silicon nitride waveguides (2013)

Planar waveguides made of Nd3+-doped silicon rich silicon oxide (SRSO) and silicon rich silicon nitride (SRSN) have been fabricated by reactive magnetron sputtering and characterized with special emphasis on the comparison of the guided photoluminescence (PL) properties of these two matrices. Guided fluorescence excited by top surface pumping at 488 nm on planar waveguides was measured as a function of the distance between the excitation area and the output of the waveguide, as well as a function of the pump power density. The PL intensity increased linearly with pump power without any saturation even at high power. The linear intensity increase of the Nd3+ guided PL under a non-resonant excitation (488 nm) confirms the efficient coupling between either Si-np and rare-earth ions for SRSO or radiative defects and rare earth ions for SRSN. The guided fluorescences at 945 and 1100 nm were observed until 4 mm and 8 mm of the output of the waveguide for Nd3+ doped SRSO and SRSN waveguides, respectively. The guided fluorescence decays of Nd3+-doped-SRSO and -SRSN planar waveguides have been measured and found equal to 97 μs ±7 and 5 μs ± 2, respectively. These results show notably that the Nd3+-doped silicon rich silicon oxide is a very promising candidate on the way to achieve a laser cavity at 1.06 μm.
When to Finish? Optimal Beam Search for Neural Text Generation (modulo beam size) (2017)

In neural text generation such as neural machine translation, summarization, and image captioning, beam search is widely used to improve the output text quality. However, in the neural generation setting, hypotheses can finish in different steps, which makes it difficult to decide when to end beam search to ensure optimality. We propose a provably optimal beam search algorithm that will always return the optimal-score complete hypothesis (modulo beam size), and finish as soon as the optimality is established. To counter neural generation’s tendency for shorter hypotheses, we also introduce a bounded length reward mechanism which allows a modified version of our beam search algorithm to remain optimal. Experiments on neural machine translation demonstrate that our principled beam search algorithm leads to improvement in BLEU score over previously proposed alternatives.
Blockchain for IoT security and privacy: The case study of a smart home (2017)

Internet of Things (IoT) security and privacy remain a major challenge, mainly due to the massive scale and distributed nature of IoT networks. Blockchain-based approaches provide decentralized security and privacy, yet they involve significant energy, delay, and computational overhead that is not suitable for most resource-constrained IoT devices. In our previous work, we presented a lightweight instantiation of a BC particularly geared for use in IoT by eliminating the Proof of Work (POW) and the concept of coins. Our approach was exemplified in a smart home setting and consists of three main tiers namely: cloud storage, overlay, and smart home. In this paper we delve deeper and outline the various core components and functions of the smart home tier. Each smart home is equipped with an always online, high resource device, known as “miner” that is responsible for handling all communication within and external to the home. The miner also preserves a private and secure BC, used for controlling and auditing communications. We show that our proposed BC-based smart home framework is secure by thoroughly analysing its security with respect to the fundamental security goals of confidentiality, integrity, and availability. Finally, we present simulation results to highlight that the overheads (in terms of traffic, processing time and energy consumption) introduced by our approach are insignificant relative to its security and privacy gains.
A QUALITY-BASED INVENTORY ISSUE POLICY FOR PERISHABLE FOODS (1989)

Inventory issue policies that are based on elapsed storage time do not account for nonuniform deterioration within a perishable inventory stockpile. The literature on keeping quality of perishable food provides ample evidence of the direct relationship between storage temperature and quality deterioration. Because varying temperature condition may be encountered during storage and distribution of perishable foods, each item in an inventory stockpile may have a different deterioration history. The time-based first-in first-out (FIFO) and last-in first-out (LIFO) issue policies, in additional, to a quality-based issue criterion, the shortest remaining shelf-life (SRSL) issue policy were examined with a computer simulation of frozen broccoli stored in temperature varying conditions. The SRSL issue policy showed advantages over both the FIFO and LIFO policies in that items issued under the SRSL policy were of equal or higher average quality, with less quality variation at time of issue. The use of the SRSL issue policy in conjunction with full-history time-temperature indicators to predict temperature dependent changes in food quality is discussed.
Prognostic Nutritional Index as a Predictor of Mortality in 101,616 Patients Undergoing Hemodialysis (2023)

High mortality in dialysis patients is linked to malnutrition and inflammation. Prognostic nutritional index (PNI), calculated from serum albumin level and total lymphocyte count, has been developed as a prognostic marker for cancer patients. We investigated the clinical utility of PNI in predicting mortality in patients undergoing hemodialysis. Thus, 101,616 patients who initiated hemodialysis in United States dialysis centers between 2007 and 2011 were included in this retrospective cohort study. Using the Cox regression model, we assessed the relationship between PNI and mortality. Further, the predictive value of PNI for one-year mortality was compared with that of its constituent using area under the receiver operating characteristic curve, net reclassification improvement, and integrated discrimination improvement. Higher PNI quartiles were incrementally associated with lower mortality; in patients with PNI values of 39.5−<43.1, 43.1−<46.6, and ≥46.6 (reference: PNI < 39.5), case-mix adjusted hazard ratios (95% confidence intervals) were 0.66 (0.64, 0.68), 0.49 (0.48, 0.51), and 0.36 (0.34, 0.37), respectively. PNI predicted mortality better than serum albumin level or total lymphocyte count alone. In the subgroup analysis, PNI performed well in predicting mortality in patients aged < 65 years. Our results indicate that PNI is a simple and practical prognostic marker in patients undergoing hemodialysis.
Peripheral neuropathies in Waldenstrom's macroglobulinaemia (2006)

Peripheral nerve symptoms and signs occur more frequently in patients with WM than controls, involve sensory modalities, and are often associated with gait disorders. IgM binding to MAG or sulphatide is associated with a further increase in the frequency and severity of peripheral nerve involvement. Age related changes, similar to those in controls, add to the degree of reduced nerve function in patients with WM.
Stimulating proactive fault detection in distributed systems (2007)

Fault Tolerance is an important issue considered when developing a reliable Distributed System. Reactive fault systems are designed to redistribute the current process on to other machines when failure occurs. In contrast to the conventional method of reactive recovery, an emerging concept in the field of fault tolerance is a proactive approach. This approach exploits pre fault symptoms and initiates fault recovery henceforth. This project is to implement a proactive fault prediction simulator for a distributed system. This will include developing a language for simulation, which allows the user to define a distributed system. The language is further used to develop an environment that integrates two fault prediction algorithms, Wilcoxon s Rank-Sum and DFT (Dispersion Frame Technique). Both these algorithms are presented as alternatives for SMART (Self Monitoring Analysis and Reporting Technology) in this project. The project also includes a comparison metrics for these prediction algorithms in terms of prediction precision and prediction accuracy.
Swept Wing-Tip Shapes for Low-Speed Airplanes (1985)

&lt;div class="htmlview paragraph"&gt;Preliminary results are presented of a study conducted to analyze the effects of several planform modifications on the aerodynamic characteristics of a high-aspect-ratio, natural laminar flow (NLF) wing. The study addresses the potential aerodynamic improvements available at both cruise and high angles of attack by use of swept wing-tip shapes. The swept wing tip appears to offer a viable addition to the lift of wing-tip designs which provide improvements in aerodynamic efficiency, with the added safety benefit of providing high angle-of-attack departure resistance. &lt;/div&gt;
The Human “Prion-like” Protein Doppel Is Expressed in Both Sertoli Cells and Spermatozoa (2002)

The prion-like Doppel protein (Dpl) has many biochemical and structural properties in common with the cellular prion protein (PrP(c)), and the physiological role of neither protein is known. Experimental data suggest either direct or indirect interaction between the two proteins. In this study, we investigated the expression pattern and biochemical characteristics of Dpl in human tissues and in Chinese hamster ovary cells transfected with wild-type or variant human Dpl gene constructs. Human Dpl appears to be a glycosylphosphatidylinositol-anchored glycoprotein with N- and O-linked sugars. It was found on Sertoli cells in the testis, on the flagella of epididymal and mature spermatozoa, and in seminal plasma. Dpl coexists only with N-terminally truncated isoforms of PrP(c) on mature spermatozoa. The localization of human Dpl on both Sertoli cells (somatic cells) and spermatozoa (germinal cells) strongly suggests that this protein may play a major role in human male fertility. Finally, our data indicate that spermatozoa are thus an interesting model for studies of the potential interaction between Dpl and PrP(c).
Crystallographic Coalescence of Crystalline Silicon Clusters into Superlattice Structures (2015)

The crystallographic coalescence of crystalline silicon clusters into superlattice structures, generated by direct deposition of a silicon cluster beam on a graphene substrate, has been observed. High-resolution transmission electron microscopy and transmission electron diffraction analyses revealed that adjacent silicon clusters in the superlattices, having a mean diameter of 1.61 ± 0.05 nm (n = 109, n indicating the cluster size, Sin) and an sp3 diamond structure, form sp3 covalent bonds between Si atoms on their surfaces and align their atomic crystalline axes, forming crystallographic rows to coalesce into bcc superlattice structures with a lattice constant of 2.134 ± 0.002 nm. The hcp configuration of the silicon clusters with the same lattice constant as the bcc superlattice unit cell is commensurate with the crystallographic structure of the graphene substrate. The absorption spectra confirm the sp3 diamond structure of the silicon clusters under well-quantized conditions. Oxygen-free unoccupied electronic states (UDOS) in the conduction band of the silicon cluster superlattices appeared at 99.8 eV in the electron energy loss spectroscopy spectra. The s + d UDOS at 107.5 eV in SiO2 became conspicuous as the oxidation of the specimen advanced. The collective bulk plasmon loss of the virtually oxygen-free silicon cluster superlattice appeared at 16.7 eV.
Band-to-band recombination peak in the light emission of commercial pseudomorphic HEMTs (1995)

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FERET (Face Recognition Technology) Recognition Algorithm Development and Test Results. (1996)

As part of the Face Recognition Technology (FERET) program, the U.S. Army Research Laboratory (ARL) conducted supervised government tests and evaluations of automatic face recognition algorithms. The goal of the tests was to provide an independent method of evaluating algorithms and assessing the state of the art in automatic face recognition. This report describes the design and presents the results of the August1994andMarch1995FERET tests. Results for FERET tests administered by ARL between August 1994 and August 1996 are reported.
BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus (2015)

The transition to pulmonary respiration after birth requires rapid alterations in the structure of the mammalian cardiovascular system. One dramatic change that occurs is the closure of the ductus arteriosus (DA), an arterial connection in the fetus that directs blood flow away from the pulmonary circulation. Two members of the TGFβ family, bone morphogenetic protein 9 (BMP9) and BMP10, have been recently involved in postnatal angiogenesis, both being necessary for remodeling of newly formed microvascular beds. The aim of the present work was to study whether BMP9 and BMP10 could be involved in closure of the DA. We found that Bmp9 knockout in mice led to an imperfect closure of the DA. Further, addition of a neutralizing anti-BMP10 antibody at postnatal day 1 (P1) and P3 in these pups exacerbated the remodeling defect and led to a reopening of the DA at P4. Transmission electron microscopy images and immunofluorescence stainings suggested that this effect could be due to a defect in intimal cell differentiation from endothelial to mesenchymal cells, associated with a lack of extracellular matrix deposition within the center of the DA. This result was supported by the identification of the regulation by BMP9 and BMP10 of several genes known to be involved in this process. The involvement of these BMPs was further supported by human genomic data because we could define a critical region in chromosome 2 encoding eight genes including BMP10 that correlated with the presence of a patent DA. Together, these data establish roles for BMP9 and BMP10 in DA closure.
Clinical pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant, in healthy volunteers. (1988)

The cardiovascular, anticholinergic and central effects of single doses of 30, 45 and 60 mg of sibutramine hydrochloride (BTS 54524), a new potential antidepressant, were compared with amitriptyline (50 mg) and placebo given at weekly intervals in a randomised design to six healthy male volunteers. Sibutramine was associated with increases in both supine heart rate and systolic blood pressure at 1, 2 and 6 h after 60 mg (P less than 0.05). Amitriptyline caused a significant 50-60% decrease in salivation compared with placebo at 2 and 6 h but there were no changes with sibutramine. No significant changes in pupil size were detected with either drug. Visual analogue rating scales (VARS) revealed significant drowsiness with amitriptyline but neither sedative nor stimulant effects with sibutramine. Impairments of simple auditory and visual reaction times, visual two-choice reaction time, finger tapping and trail making, measured using an automated test battery, occurred with amitriptyline compared with sibutramine. If sibutramine proves to be an effective antidepressant it should be devoid of anticholinergic or central depressant effects. Chronic dosage studies are indicated to evaluate the clinical significance of its cardiovascular effects.
Acute Carpal Tunnel Syndrome Secondary to Pseudogout (1976)

Acute carpal tunnel syndrome secondary to chondrocalcinosis seems not to have been previously reported. In a 75-year-old woman, with arthropathy and calcification of the triangular fibrocartilage of the wrist, hyperparathyroidism was suspected, but not proven. Hydroxyapatite and calcium pyrophosphate crystals were found together in the pathological specimen. The patient obtained complete relief from sectioning of the transverse carpal ligament.
Electrophysiology of Heart Failure (2019)

Electrocardiographic imaging (ECGI) computes electric potentials on the epicardial surfaces of the heart from measured potentials on the body surface. The high-resolution panoramic ECGI maps provide detailed information on the electrophysiological (EP) substrate and its dynamic modulation by pacing. This chapter explains the effects of cardiac resynchronization therapy (CRT) on ventricular activation and electrical synchrony. High-resolution, single-beat mapping with non-invasive ECGI of EP substrate and ventricular tachycardia (VT) in patients provides information that can facilitate CRT and substrate-based ablation of VT. Non-invasive ECGI is used to map cardiac electrical excitation in heart failure (HF) patients. Remodeling processes in HF alter the cell EP and calcium cycling, as well as the tissue structure, thus providing substrate for slow conduction and conduction block. ECGI could possibly be used to quantify electrical synchrony, identify potential responders/non-responders to CRT, and guide electrode placement for effective resynchronization.
Bio-Encapsulation Within Sol-Gel Glasses (2000)

Abstract The sol-gel process opens new possibilities in the field of biotechnology. Enzymes such as glucose oxydase and lipase can be trapped within sol-gel glasses without loosing their bioactivity. Small analytes diffuse through the pores of the silica matrix allowing in-situ biocatalytic reactions to be performed. Escherichia coli bacteria have also been encapsulated. Their cellular organization is preserved and they still exhibit noticeable enzymatic activity, even on dried xerogels. Antibody-antigen recognition has been shown to be feasible within sol-gel matrices and whole cell protozoa have been used as antigens for blood tests with human sera.
Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation (2023)

Patients with atrial fibrillation and high burden of microbleeds receiving combination therapy have a tendency of higher rate of intracranial hemorrhage than ischemic stroke, with potential for net harm. Further studies are needed to help optimize stroke preventive strategies in this high-risk group. ANN NEUROL 2023;94:61-74.
Tabletop CT system for 3-D in-vitro analysis of arterial flow and distensibility (1990)

We have developed a table-top CT system with high temporal and spatial resolution which can be used to quantify the 3-D flow patterns and arterial wall distensibility in intact arterial samples. Our system comprises of an x-ray image intensifier optically coupled to a linear photo-diode array camera. The arterial phantom or sample is irradiated by a narrow beam and a projection image of a thin slice through the sample is obtained with a temporal resolution of 17 ms. The spatial resolution in the CT images is 2 mm. The system can be used in two modes: flow quantification and dynamic motion quantification. In flow quantification mode an image is formed of a bolus of radio-opaque dye as it flows past the plane of interest. Repeated bolus injections, performed as the arterial phantom is rotated through 180, yield a series of timeposition projection images of the flowing bolus. These projection images are reconstructed using CT techniques to produce a 3-D time-position map of the flowing bolus. In dynamic motion quantification mode, time-position maps are obtained from many orientations as fluid is pumped through an arterial sample. Pulsatile flow is provided by a computer controlled pump which generates reproducible physiological flow and pressure waveforms. The collection of each projection image is gated to the beginning of the cardiac cycle. Again, usIng CT techniques we obtain cross-sectional images of the arterial sample at 60 points of the 'cardiac' cycle.
Control of cavity lifetime of 15 µm wafer-fused VCSELs by digital mirror trimming (2014)

Digital chemical etching is used to trim the output mirror thickness of wafer-fused VCSELs emitting at a wavelength near 1.5µm. The fine control of the photon cavity lifetime thus achieved is employed to extract important device parameters and optimize the combination of the threshold current, output power, and direct current modulation characteristics. The fabrication process is compatible with industrial production and should help in improving device yield and in reducing manufacturing costs.
Extracting the channel allocation information in a spectrum pooling system using a prefilter delay and multiply nonlinearity (2004)

The spectrum pooling concept is a resource sharing strategy, which allows a license owner to share a sporadically used part of his licensed spectrum with a renter system, until he needs it himself. In order to make such a resource sharing plausible for a license owner, the impact of this strategy on the operation of the license owner system must be kept at a minimum. This means the renter system must extract the channel allocation information (CAI) from the channel, i.e. it has to detect, which parts of the shared spectrum the owner system accesses to, in order to immediately vacate the frequency bands being required by the owner and to gain access to the frequency bands, which the owner has stopped using. In this paper we propose a method for the extraction of the CAI using a prefilter delay and multiply nonlinearity in a specific spectrum pooling scenario, where the license owner is a GSM network and the spectrum renter is an OFDM based WLAN system.
Current Status for Soft X-ray/Extreme Ultra-Violet Optical Devices (2014)

The considerable progress in the development of soft x-ray / extreme ultra-violet (EUV) sources such as laser produced plasma, high-harmonic generation, synchrotron radiation, x-ray free electron laser will create new scientifi c fi eld and new industrial technology fi eld. These soft x-ray/EUV sources research have also led to progress in the development of soft x-ray/EUV optical devices such as multilayer mirrors and Fresnel zone plates. This paper reviews the recent these optics.
Analyse und Optimierung von Gasphasen‐Reaktionen, XVII. Selenoketen (1980)

Abstract Die thermische Zersetzung von 1,2,3‐Selenadiazol in der Gasphase wurde photoelektronen‐ und massenspektroskopisch verfolgt. Bei Temperaturen oberhalb 720 K entsteht Selenoketen, dessen PE‐Spektrum anhand von ab initio‐SCF‐Rechnungen sowie durch Radikalkation‐Zustandsvergleich mit den iso(valenz) elektronischen Heterokumulenen H 2 C  C  O und H 2 C  C  S zugeordnet werden kann. Das 4‐Phenyl‐Derivat zerfällt oberhalb 820 K zu Phenylacetylen.