gebhart/patrepeval huggingface dataset:
Steroidal Aldosterone Antagonists. VI1 (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroidal Aldosterone Antagonists. VI1Leonard N. Nysted and Robert R. BurtnerCite this: J. Org. Chem. 1962, 27, 9, 3175–3177Publication Date (Print):September 1, 1962Publication History Published online1 May 2002Published inissue 1 September 1962https://pubs.acs.org/doi/10.1021/jo01056a046https://doi.org/10.1021/jo01056a046research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human Papillomavirus Type 16 L2 Gene Sequence Variation Analysis in Indonesian Cervical Cancer Specimens (2021)

Abstract Background: Human papillomavirus type 16 (HPV16) is the most common etiological cause of cervical cancer in Indonesian women. HPV16 L2 genetic variation analysis is important for vaccine strategies of cervical cancer, yet the data in Indonesia is still limited. In this research, we determined the variation of the HPV16 L2 gene sequences in Indonesian cervical cancer specimens. Method: We cross-sectionally observed a total of 23 DNA isolates of HPV16 positive specimens stored in the laboratory of the Center for Diagnostic and Research on Infectious Diseases (PDRPI Lab) Faculty of Medicine, Universitas Andalas, Padang, Indonesia. The HPV16 L2 genes were amplified, sequenced, and followed by DNA alignment, single nucleotide polymorphisms (SNPs) analysis, and phylogenetic tree reconstruction. Results: As many as 35 SNPs were found, consist of 18 synonymous SNPs (sSNPs) and 17 non-synonymous SNPs (nsSNPs). Amino acid variations were mostly detected at S269P (100%) and L330F (43.48%) with no variation in the immuno-protective region near L2 N-terminus. A total of 5 HPV16 phylogenetic sub-lineages were found closely related to A1 ( n =5), A2 ( n =12), A3 ( n =2), A4 ( n =3), and C ( n =1). Conclusion: The variation of HPV16 L2 gene sequences was mostly located on the central region of the L2 sequences and the cross-protective region near the L2 N-terminus was particularly conserved. This study should enhance the information about HPV16 L2 gene variation in Indonesia.
Renal Lesions and Nephrotoxicity: Contemporary Challenges and Future Directions (2023)

Renal lesions and nephrotoxicity are major challenges for researchers and patients alike [...].
Therapeutic effects of dihydroartemisinin and transferrin against glioblastoma (2016)

The results of this study demonstrated that DHA, the derivative of the active ingredient in Gaeddongssuk, is effective against GBM, apparently via inhibition of cancer cell proliferation by a pharmacological effect. The role of transferrin as an allosteric activator in the GBM therapeutic efficacy of DHA was also confirmed.
GHRP historical perspective (2000)

The growth hormone releasing peptides (GHRPs), in contrast to growth hormone releasing hormone (GHRH), were invented rather than discovered. “Reverse pharmacology,” a term recently proposed by Michael Conn, was suggested to designate the developmental GHRP process (1). GHRPs and their mimetics will undoubtedly have a clinical role in the future. Two immediate future objectives of salient importance will be isolation and identification of the putative native hormone for which GHRPs are mimetics and elucidation of its role in the physiological secretion of GH. Moreover, whether this hormone is involved in the pathophysiology of GH deficiency in children and adults is still to be determined.
Gallium arsenide films on recrystallized germanium films (1977)

Germanium films deposited on tungsten/graphite substrates have been recrystallized by a unidirectional solidification technique. Gallium arsenide films deposited on recrystallized germanium have elogated grains with a strong {111} preferred orientation and are epitaxial with respect to the substrate. The deposited films have a room-temperature Hall mobility of 600–700 cm2/V sec and electron concentration of (1–3) ×1017 cm−3.
Vascular remodelling during the normal and malignant life cycle of the mammary gland (2001)

The mammary gland life cycle is exemplified by massive, physiologically dictated changes in cell number and composition, architecture, and functionality. These drastic upheavals, by necessity, also involve the mammary endothelium, which undergoes angiogenic expansion during pregnancy and lactation followed by ordered regression during involution. In this review, we summarise data obtained using the Mercox methyl methacrylate corrosion cast technique to analyse the mammary gland vasculature during normal development and carcinogenesis. Concomitant with epithelial cell expansion, the mammary vasculature grows during the first half of pregnancy by sprouting angiogenesis whereas the last half of pregnancy and lactation are characterised by the non-proliferative intussusceptive angiogenesis. The vasculature of the lactating gland is composed of a well-developed capillary meshwork enveloping the secretory alveoli with basket-like honeycomb structures. During involution, regression of the vasculature is achieved by regional collapse of the honeycomb structures, capillary retraction, and endothelial attenuation. This process appears partly to involve apoptosis. However, an additional mechanism involving remodelling without cell death, which we have termed angiomeiosis, must exist to explain the morphological observations. Interestingly, in mammary tumours of neuT transgenic mice, both sprouting and intussusceptive angiogenesis was observed simultaneously in the same nodules, a finding with potential implications for cancer therapy. The underlying molecular mechanisms controlling angiogenic modulation in the mammary gland, particularly angiogenic regression and the endothelial:parenchymal interplay, are poorly understood. However, the data summarised in this review indicate that precisely these molecular mechanisms offer novel alternatives for specific and effective treatment of breast cancer.
Low area Elliptic Curve arithmetic unit (2009)

In this paper, a generic elliptic curve (EC) arithmetic unit with high flexibility and small chip covered area is proposed. This EC arithmetic unit is based on the one dimensional systolic architectural realization of a proposed modified multiplication - inversion algorithm that through appropriate initialization uses the algorithmic structure of inversion to also perform multiplication. The proposed architecture is realized on FPGA for GF(2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">163</sup> ) and is compared with similar up-to-date designs. The proposed EC arithmetic unit has very small chip covered area without any serious penalty in calculation delay and since is designed on the affine coordinate plane, it offers a good side channel attack resistance base for further optimizations on this field.
Semi‐synthetic motor oils derived from high paraffinic petroleum base stock (2007)

Purpose To prepare semi‐synthetic oils satisfying the classification API SF/CC and SAE 10W30 from mineral base oils derived from high paraffinic petroleum, synthetic alkylbenzenes base oils, and suitable additives. Design/methodology/approach The mixtures of base mineral oils of deep hydro‐isomerization derived from high‐paraffinic petroleum (viscosity at 100°C is 12.5 cSt) and the mixtures of the synthetic alkyl aromatics oils with the naphthenic components (viscosity at 100°C of 8.0 cSt) were used as base oil. viscosity‐temperature properties, pour points, and flash points were modified by mixing of suitable additives. Octan M‐1, Octan M‐2, Octan M‐3, and Octan M‐4 oils were obtained by application of suitable additives into the prepared base oils B‐C. In order to get the SAE 10W30 requirements the viscous additive was added (0.4‐0.6 mass percent) to prepared base oils. For obtaining the API/SF/CC grade oils, package additive (Hitec 9229) additive was added (4.7 mass percent) to the mixture. The oil (Octan M‐1) was tested in the engine of Mercedes‐Benz model 230 car and positive results over 20,000 km running. Findings It was observed that, viscosities and pour points change linearly as the mass percent of alkylbenzenes the in the base oil mixture is changed. This realizes the possibility of the creation of semi‐synthetic motor oil of desired properties in the case of lack of other low‐viscosity synthetic component such as poly‐á‐olefins, diester and polyester oil. The obtained oils are useful for service in relatively mild climatic conditions (average temperature of the winter period −15 to −30°C). Research limitations/implications The obtained oils cannot fully satisfy the requirements of the engines by pour point and low‐temperature characteristics in the absence of additives. Practical implications Because of complexity of obtained mixture, it was impossible to study the structure and composition of the obtained products by modern techniques such as high field NMR spectroscopy. Originality/value Details practical information on preparation of four semi‐synthetic oils satisfying the classification API SF/CC are reported.
High intensity of Tunga penetrans infection causing severe disease among pigs in Busoga, South Eastern Uganda (2017)

The presentations of tungiasis highlighted in this report show that high intensities of embedded T. penetrans can cause a severe clinical disease in pigs. Effective tungiasis preventive measures and early diagnosis for treatment could be crucial to minimize its effects on animal health.
Detecting and resolving constraint conflicts in role-based access control (2011)

The focus of existing researches on RBAC constraints has been predominantly on the specification of constraints, the detection and resolution of constraint conflicts have been overlooked and remain a significant research challenge. To address these concerns, we propose a set of detection rules for these conflicts. Furthermore, a flexible approach is provided to resolve internal constraint conflicts by defining two new concepts, i.e., priority rule and resolution policy.
Analysis of Pathologic Complete Response 10 Weeks After Radiotherapy—A Radiobiological Sin—In Reply (2019)

In Reply We thank all the authors for their thoughtful comments on the Measuring the Integration of Stereotactic Ablative Radiotherapy Plus Surgery for Early Stage Non–Small Cell Lung Cancer (MISSILE-NSCLC) study.1 We wish to briefly discuss some of the main points raised.
Osteogenesis from Human Induced Pluripotent Stem Cells: An In Vitro and In Vivo Comparison with Mesenchymal Stem Cells (2014)

The purpose of this study was to examine the in vitro and in vivo osteogenic potential of human induced pluripotent stem cells (hiPSCs) against that of human bone marrow mesenchymal stem cells (hBMMSCs). Embryoid bodies (EBs), which were formed from undifferentiated hiPSCs, were dissociated into single cells and underwent osteogenic differentiation using the same medium as hBMMSCs for 14 days. Osteoinduced hiPSCs were implanted on the critical-size calvarial defects and long bone segmental defects in rats. The healing of defects was evaluated after 8 weeks and 12 weeks of implantation, respectively. Osteoinduced hiPSCs showed relatively lower and delayed in vitro expressions of the osteogenic marker COL1A1 and bone sialoprotein, as well as a weaker osteogenic differentiation through alkaline phosphatase staining and mineralization through Alizarin red staining compared with hBMMSCs. Calvarial defects treated with osteoinduced hiPSCs had comparable quality of new bone formation, including full restoration of bone width and robust formation of trabeculae, to those treated with hBMMSCs. Both osteoinduced hiPSCs and hBMMSCs persisted in regenerated bone after 8 weeks of implantation. In critical-size long bone segmental defects, osteoinduced hiPSC treatment also led to healing of segmental defects comparable to osteoinduced hBMMSC treatment after 12 weeks. In conclusion, despite delayed in vitro osteogenesis, hiPSCs have an in vivo osteogenic potential as good as hBMMSCs.
Compositionality in neural control: an interdisciplinary study of scribbling movements in primates (2013)

This article discusses the compositional structure of hand movements by analyzing and modeling neural and behavioral data obtained from experiments where a monkey (Macaca fascicularis) performed scribbling movements induced by a search task. Using geometrically based approaches to movement segmentation, it is shown that the hand trajectories are composed of elementary segments that are primarily parabolic in shape. The segments could be categorized into a small number of classes on the basis of decreasing intra-class variance over the course of training. A separate classification of the neural data employing a hidden Markov model showed a coincidence of the neural states with the behavioral categories. An additional analysis of both types of data by a data mining method provided evidence that the neural activity patterns underlying the behavioral primitives were formed by sets of specific and precise spike patterns. A geometric description of the movement trajectories, together with precise neural timing data indicates a compositional variant of a realistic synfire chain model. This model reproduces the typical shapes and temporal properties of the trajectories; hence the structure and composition of the primitives may reflect meaningful behavior.
InP Grown on Si Substrates with GaP Buffer Layers by Metalorganic Chemical Vapor Deposition (1989)

InP epilayers are grown on Si substrates with buffer layers of InAs, GaAs, or GaP. The buffer layers are grown on Si below their crystallizing temperatures, and then InP epilayers are grown on top of them using a conventional two-step growth method. GaP is the best of the three buffer layer materials and the optimum thickness is about 17 nm. The InP epilayers grown on Si with GaP buffer layers have higher crystalline quality than either those grown directly on Si or those grown with GaAs intermediate layers. The full width at half maximum of the (400) reflection obtained from annealed 7.8-µm-thick InP epilayer is as small as 240 arcseconds and the etch pit density is 3.0×10 7 cm -2
Overview of Materials and Power Applications of Coated Conductors Project (2012)

There are high expectations for coated conductors in electric power applications such as superconducting magnetic energy storage (SMES) systems, power cables, and transformers owing to their ability to contribute to stabilizing and increasing the capacity of the electric power supply grid as well as to reducing CO2 emission as a result of their high critical-current characteristics. Research and development has been performed on wires/tapes and electric power devices worldwide. The Materials and Power Applications of Coated Conductors (M-PACC) Project is a five-year national project in Japan started in 2008, supported by the Ministry of Economy, Trade and Industry (METI) and the New Energy and Industrial Technology Development Organization (NEDO), to develop both coated conductors that meet market requirements and basic technologies for the above-mentioned power applications using coated conductors. In this article, research and development results are reviewed and compared with the interim/final targets of the project, and future prospects are discussed.
Cell Phone Use and Parotid Salivary Gland Alterations: No Molecular Evidence (2014)

We provide molecular evidence that the exposure of parotid glands to cell phone use does not alter parotid salivary flow, protein concentration, or levels of proteins of genes that are directly or indirectly affected by heat-induced cellular stress.
ILP Based Gate Leakage Optimization Using DKCMOS Library during RTL Synthesis (2008)

In this paper dual-K (DKCMOS) technology is proposed as a method for gate leakage power reduction. An integer linear programming (ILP) based algorithm is proposed for its optimization during architectural synthesis. The algorithm uses device-level gate leakage models for precharacterizing register-transfer level (RTL) datapath component library and minimizes the leakage delay product (LDP). The proposed algorithm is tested for several circuits for 45nm CMOS technology node. The experiments show that average gate leakage reduction are 67.7 % and 80.8 % for SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> - SiON and SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> , respectively.
Islam in India: Studies and Commentaries. Vol. 2: Religion and Religious Education. Edited by Christian W. Troll. New Delhi: Vikas Publishing House, 1985. xx, 315 pp. Index. Rs. 150. (1986)

Book Review| February 01 1986 Islam in India: Studies and Commentaries. Vol. 2: Religion and Religious Education Islam in India: Studies and Commentaries. Vol. 2: Religion and Religious Education. Edited by Christian W. Troll. New Delhi: Vikas Publishing House, 1985. xx, 315 pp. Index. Rs. 150. Gregory C. Kozlowski Gregory C. Kozlowski DePaul University Search for other works by this author on: This Site Google Journal of Asian Studies (1986) 45 (2): 432–434. https://doi.org/10.2307/2055891 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Permissions Cite Icon Cite Search Site Citation Gregory C. Kozlowski; Islam in India: Studies and Commentaries. Vol. 2: Religion and Religious Education. Journal of Asian Studies 1 February 1986; 45 (2): 432–434. doi: https://doi.org/10.2307/2055891 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsJournal of Asian Studies Search Advanced Search The text of this article is only available as a PDF. Copyright © Association for Asian Studies, Inc. 19861986 Article PDF first page preview Close Modal You do not currently have access to this content.
Lidar equation analysis allowing for target lifetime, laser pulse duration, and detector integration period (1977)

A detailed study of the lidar equation has been made for both scattering and fluorescent targets. Allowance has been made for the effects of finite excited state lifetime, optical depth, laser pulse duration, detector integration period, and laser pulse shape. Analytical solutions have been obtained, and graphical solutions are also presented to aid in evaluating the magnitude of the correction factor appropriate to several cases of interest.
Structural biology and structure–function relationships of membrane proteins (2018)

The study of structure-function relationships of membrane proteins (MPs) has been one of the major goals in the field of structural biology. Many Noble Prizes regarding remarkable accomplishments in MP structure determination and biochemistry have been awarded over the last few decades. Mutations or improper folding of these proteins are associated with numerous serious illnesses. Therefore, as important drug targets, the study of their primary sequence and three-dimensional fold, combined with cell-based assays, provides vital information about their structure-function relationships. Today, this information is vital to drug discovery and medicine. In the last two decades, many have been the technical advances and breakthroughs in the field of MP structural biology that have contributed to an exponential growth in the number of unique MP structures in the Protein Data Bank. Nevertheless, given the medical importance and many unanswered questions, it will never be an excess of MP structures, regardless of the method used. Owing to the extension of the field, in this brief review, we will only focus on structure-function relationships of the three most significant pharmaceutical classes: G protein-coupled receptors, ion channels and transporters.
Transapical left ventricular access for difficult to reach interventional targets in the left heart (2008)

Direct left ventricular puncture offers a very useful alternative access site in selected patients to reach "inaccessible" targets for certain percutaneous interventions in patients where standard approaches may be impossible or difficult.
Data from Reduced PDEF Expression Increases Invasion and Expression of Mesenchymal Genes in Prostate Cancer Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;The epithelium-specific Ets transcription factor, PDEF, plays a role in prostate and breast cancer, although its precise function has not been established. In prostate cancer, PDEF is involved in regulating prostate-specific antigen expression via interaction with the androgen receptor and NKX3.1, and down-regulation of PDEF by antiproliferative agents has been associated with reduced PDEF expression. We now report that reduced expression of PDEF leads to a morphologic change, increased migration and invasiveness in prostate cancer cells, reminiscent of transforming growth factor β (TGFβ) function and epithelial-to-mesenchymal transition. Indeed, inhibition of PDEF expression triggers a transcriptional program of genes involved in the TGFβ pathway, migration, invasion, adhesion, and epithelial dedifferentiation. Our results establish PDEF as a critical regulator of genes involved in cell motility, invasion, and adhesion of prostate cancer cells. [Cancer Res 2007;67(9):4219–26]&lt;/p&gt;&lt;/div&gt;
Beiträge zur Chemie der Silicium—Stickstoff‐Verbindungen. XXXIX. Tris‐[trialkoxysilyl]‐amine (1964)

Abstract Tris‐[trialkoxysilyl]‐amine lassen sich von Hexaalkoxydisilazanen ausgehend über die Alkali‐bis‐[trialkoxysilyl]‐amide und Bis‐[trialkoxysilyl]‐trichlorsilyl‐amine mit guten Ausbeuten darstellen. Unter ihnen zeichnet sich das Tris‐[triisopropoxysilyl]‐amin durch eine besondere Hydrolysebeständigkeit aus.
Spontaneous regeneration of keratinized tissue at implants and teeth (2023)

After excision of KT at implant sites, the spontaneous regeneration of the soft tissue is characterized by a non-keratinized epithelium typical for alveolar mucosa, while at tooth sites the spontaneous regeneration was characterized by soft tissue resembling gingiva.
Insulin Sensitivity in Patients with Primary Aldosteronism: A Follow-Up Study (2006)

Insulin resistance is present in patients with tumoral and idiopathic aldosteronism, but the defect appears less severe than in patients with essential hypertension. Treatment with surgery or aldosterone antagonists restores rapidly and persistently normal sensitivity to insulin.