gebhart/patrepeval huggingface dataset:
Ontology-Based Translation of Business Process Models (2009)

Semantic Business Process Management is a recent and promising research area devoted to extending the results from Semantic Web Services - i.e., the application of ontology-based modelling and reasoning to Web Services - to Business Process Management, which is these days often realised using Service-Oriented Architectures. One important task for Semantic Business Process Management is the addition of corresponding semantic annotations to the business-oriented view on processes. Since, however, the Semantic Web approach, realised using ontologies, is not simply to represent conceptualisations in the style of a data model, but to embody relationships and inferences over such conceptualisations, an equally important task to realise Semantic Business Process Management is hence to relate business-oriented and IT/service-oriented views of processes ontologically. Previous work has shown how an ontology language rich enough to encode rules can provide a relationship between an abstract ontology for business processes and a low-level ontological representation of process behaviour providing behavioural semantics for these business processes. In this paper we show how business-oriented and execution-oriented ontological representations of business processes can similarly be related.
Total synthesis and biological mode of action of largazole: A potent class I histone deacetylase inhibitor (2022)

The efficient total synthesis of the recently described natural substance largazole (1) and its active metabolite largazole thiol (2) is described. The synthesis required eight linear steps and proceeded in 37% overall yield. It is demonstrated that largazole is a pro-drug that is activated by removal of the octanoyl residue from the 3-hydroxy-7-mercaptohept-4-enoic acid moiety to generate the active metabolite 2, which is an extraordinarily potent Class I histone deacetylase inhibitor. Synthetic largazole and 2 have been evaluated side-by-side with FK228 and SAHA for inhibition of HDACs 1, 2, 3, and 6. Largazole and largazole thiol were further assayed for cytotoxic activity against a panel of chemoresistant melanoma cell lines, and it was found that largazole is substantially more cytotoxic than largazole thiol; this difference is attributed to differences in the cell permeability of the two substances.
Problem Setting and Modeling in Vehicles and Pedestrians Traffic Control Using Sensor Networks (2007)

A new model of vehicles and pedestrians behavior for complex crossroads road traffic control is developed here. The crossroad is equipped with a wireless sensor network as traffic detector reporting real time traffic events used in the modeling phase. The crossroad model is designed and implemented regarding the three traffic lights colors for each lane entering the junction and permits usage of complex test cases independent of the number of lanes.
Large and tunable photo-thermoelectric effect in single-layer MoS2 (2013)

We study the photoresponse of single-layer MoS2 field-effect transistors by scanning photocurrent microscopy. We find that, unlike in many other semiconductors, the photocurrent generation in single-layer MoS2 is dominated by the photo-thermoelectric effect and not by the separation of photoexcited electron-hole pairs across the Schottky barriers at the MoS2/electrode interfaces. We observe a large value for the Seebeck coefficient for single-layer MoS2 that, by an external electric field, can be tuned between -4x10^2 uV/K and -1x10^5 uV/K. This large and tunable Seebeck coefficient of the single-layer MoS2 paves the way to new applications of this material such as on-chip thermopower generation and waste thermal energy harvesting.
A Simplified Whole Blood Enzyme-linked Immunosorbent Assay (ProTrac II) for Tacrolimus (FK506) Using Proteolytic Extraction in Place of Organic Solvents (1996)

Tacrolimus (FK506) is a macrolide antibiotic with potent immunosuppressive properties. FK506 is 10- to 100-fold more potent than cyclosporin A in preventing organ rejection and in toxicity. Extreme inter- and intrapatient variability and lack of correlation between drug dosage and drug blood levels necessitate consistent and reliable therapeutic drug monitoring. Previous methods for monitoring drug levels have been lengthy and labor intensive and have required organic solvents for sample extraction. We have developed a manual enzyme-linked immunosorbent assay (ProTrac II ELISA) that employs standardized reagents and a nonorganic solvent extraction and yields good assay sensitivity and precision. The calculated mean sensitivity of the assay was 0.18 ng/ml. Interassay precision ranged from 6.3% to 13.1% (coefficient of variation) for FK506 in whole blood (concentration range, 1.0-25.0 ng/ml). Recovery of the drug from spiked EDTA whole blood was 91-98% over the same concentration range. Mean recovery of the drug from clinical samples spiked with kit standards was 99.5%. Dilutions of high-concentration spiked EDTA whole blood samples and high-concentration samples from patients exhibited linearity of observed versus expected values (y = 0.86x - 1.15; r = 0.99). Comparison of ProTrac II with the INCSTAR ProTrac FK506 ELISA by paired Student's t test showed no statistical difference between the methods (p = 0.46). Comparison of ProTrac II ELISA to the IMx microparticle enzyme immunoassay (MEIA) by linear regression resulted in a line with a slope of 1.22 (r = 0.91). Analysis by t test resulted in a p value < 0.001, indicating that the absolute values obtained in these assays are significantly different. The mean (+/-SD) difference in the absolute values was 4.2 +/- 2.6 ng/ml, with the MEIA values consistently higher. These results indicate that ProTrac II is a sensitive, precise ELISA for the determination of tacrolimus in whole blood; it can be performed in < 4 h.
Essential Oils and Their Constituents: Anticonvulsant Activity (2011)

A literature-based survey of plants species and their essential oils with anticonvulsant activity was carried out. As results, 30 species belonging to 13 families and 23 genera were identified for their activities in the experimental models used for anticonvulsant drug screening. Thirty chemical constituents of essential oils with anticonvulsant properties were described. Information on these 30 species is presented together with isolated bioactive compound studies.
Wideband dual-polarization reconfigurable elementary cell for electronic steerable reflectarray at Ku-band (2010)

This paper presents a wideband reconfigurable PIN diode-based radiating element for beam steering reflectarrays. The elementary cell consists of a circular patch coupled to a phase shifting circuit with 1-bit phase resolution (0°/180°), operating at Ku-band. The use of 1-bit phase resolution was demonstrated to be a feasible solution to substantially simplify the design of very large reconfigurable reflectarrays. In this paper the architecture of the cell is presented and performance are evaluated by a full wave simulation. Dual polarization operation and a flat phase shift response over a 50% relative bandwidth are demonstrated. An improved structure adapted to simplify manufacturing process is then presented still showing a wide relative bandwidth even in case of incidence angles of 40° in elevation.
High‐Performance Heterostructured Cathodes for Lithium‐Ion Batteries with a Ni‐Rich Layered Oxide Core and a Li‐Rich Layered Oxide Shell (2016)

The Ni‐rich layered oxides with a Ni content of &gt;0.5 are drawing much attention recently to increase the energy density of lithium‐ion batteries. However, the Ni‐rich layered oxides suffer from aggressive reaction of the cathode surface with the organic electrolyte at the higher operating voltages, resulting in consequent impedance rise and capacity fade. To overcome this difficulty, we present here a heterostructure composed of a Ni‐rich LiNi 0.7 Co 0.15 Mn 0.15 O 2 core and a Li‐rich Li 1.2− x Ni 0.2 Mn 0.6 O 2 shell, incorporating the advantageous features of the structural stability of the core and chemical stability of the shell. With a unique chemical treatment for the activation of the Li 2 MnO 3 phase of the shell, a high capacity is realized with the Li‐rich shell material. Aberration‐corrected scanning transmission electron microscopy (STEM) provides direct evidence for the formation of surface Li‐rich shell layer. As a result, the heterostructure exhibits a high capacity retention of 98% and a discharge‐voltage retention of 97% during 100 cycles with a discharge capacity of 190 mA h g −1 (at 2.0–4.5 V under C/3 rate, 1C = 200 mA g −1 ).
Intensity of the Pressure-Induced Fundamental Infrared Band of Gaseous Chlorine (1973)

The integrated intensity of the pressure-induced fundamental band of gaseous chlorine measured by Winkel, Hunt, and Clouter is about 5 times that calculated assuming that the transition moment arises from the oscillation of quadrupole-induced dipole moments. This provides good evidence that valence-type interaction between gaseous chlorine molecules occurs.
Electron Microscopy of Sprouting Seeds (1968)

The examination of living insects in the scanning electron microscope (SEM) was reported in 1966. We now report the examination of living botanical specimens in the SEM. The specimens were the seeds of white sprouting onion (Allium cepa) and of the radish (Raphanus sativus) during the week following germination. The seeds were mounted initially using flour and water and later using a cement (“Elmer's Glue All”). In all cases the natural conductance of the seeds was sufficient to prevent undue charging. 12 onion seeds were examined within three days of placing in moist tissue and again on the three successive days (Figures 1 and 2). The survival rate (5 out of 12) was not significantly lower than in the control sample (about 50% of a large number), however the growth did appear to be retarded and this may have been due to the microscope environment. One notable exception was one seed which was accidentally immersed in the cement with only the sprout uncovered; it is possible that such immersion retarded water loss to the vacuum. The cement subsequently dissolved away as the sprouting seed developed in moist tissue.
Amélioration des performances et nouveaux concepts de capteurs inertiels à détection thermique. (2011)

Ce travail de these porte sur l'etude et la realisation de micro-capteurs d'acceleration a detection thermique. Ils sont bases sur la modification des echanges thermiques par convection naturelle dans un fluide chauffe localement lorsque le dispositif est soumis a une acceleration.L'utilisation d'un fluide comme masse sismique est en rupture avec les concepts d'accelerometres dits traditionnels. Cet avantage a pour consequence directe leur tenue aux fortes accelerations.Un des objectifs de ce travail consiste a developper et a caracteriser des accelerometres a grande etendue de mesures (> 10 000 g). D'autre part, des etudes fondamentales menees en parallele nous ont permis de mieux comprendre les phenomenes thermiques intervenant dans la cavite ainsi que d'en deduire l'effet des parametres thermo-physiques du fluide, des conditions experimentales et des dimensions geometriques du capteur sur la sensibilite et la bande passante.Par ailleurs, l'etude de nouveaux concepts de detection thermique bases sur l'utilisation de materiaux pyroelectriques a ete entreprise pour aboutir a une amelioration de la sensibilite comme de la bande passante. Apres la maitrise des depots en couches minces, ce nouveau mode de detection a ete mis en œuvre et le principe valide.
Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming (2019)

Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG diversity. Recently, high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) of recombined V-(D)-J genes has offered unprecedented insights into the dynamics of IG repertoires in health and disease. Faithful biological interpretation of AIRR-seq studies depends upon the annotation of raw AIRR-seq data, using reference germline gene databases to identify the germline genes within each rearrangement. Existing reference databases are incomplete, as shown by recent AIRR-seq studies that have inferred the existence of many previously unreported polymorphisms. Completing the documentation of genetic variation in germline gene databases is therefore of crucial importance. Lymphocyte receptor genes and alleles are currently assigned by the Immunoglobulins, T cell Receptors and Major Histocompatibility Nomenclature Subcommittee of the International Union of Immunological Societies (IUIS) and managed in IMGT<sup>®</sup>, the international ImMunoGeneTics information system<sup>®</sup> (IMGT). In 2017, the IMGT Group reached agreement with a group of AIRR-seq researchers on the principles of a streamlined process for identifying and naming inferred allelic sequences, for their incorporation into IMGT<sup>®</sup>. These researchers represented the AIRR Community, a network of over 300 researchers whose objective is to promote all aspects of immunoglobulin and T-cell receptor repertoire studies, including the standardization of experimental and computational aspects of AIRR-seq data generation and analysis. The Inferred Allele Review Committee (IARC) was established by the AIRR Community to devise policies, criteria, and procedures to perform this function. Formalized evaluations of novel inferred sequences have now begun and submissions are invited via a new dedicated portal (https://ogrdb.airr-community.org). Here, we summarize recommendations developed by the IARC-focusing, to begin with, on human IGHV genes-with the goal of facilitating the acceptance of inferred allelic variants of germline IGHV genes. We believe that this initiative will improve the quality of AIRR-seq studies by facilitating the description of human IG germline gene variation, and that in time, it will expand to the documentation of TR and IG genes in many vertebrate species.
Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice (2007)

This study demonstrates uptake of IL-10-secreting L. lactis by the paracellular route in inflamed mucosal tissue. We suggest that IL-10 production by L. lactis residing inside the mucosa in the vicinity of responsive cells can improve the local action of interleukin-10 in inflamed tissue and the efficiency of the treatment.
Sci—Fri PM: Delivery — 01: Approach to evaluate the accuracy of individual control‐points of a VMAT delivery measured by an EPID (2012)

A unique approach that uses Monte Carlo (MC) methods to validate time-resolved measured dose by an electronic portal imaging device (EPID) during delivery of volumetric modulated arc therapy (VMAT) treatments was investigated. Time-resolved dose is simultaneously scored in both the patient and EPID geometries. A RapidArc© verification plan was generated and delivered on a homogeneous cylindrical phantom. Portal images were collected using an aS1000 amorphous-silicon EPID attached to a Varian Clinac 2100ix. The images were acquired in the continuous acquisition mode and in-house analysis software was used to obtain images for each control point. We performed MC simulation and dose calculation of the verification plan using the EGSnrc MC package. The MC phantom file contains both the EPID model and the cylindrical phantom derived from the CT data sets. For the individual control point simulation, we rotate the phantom only using the gantry angle information. For this work, we calculated dose distributions for five control points (out of a total of 177) in the verification plan. The normalized measured and calculated data were compared using the chi comparison (computationally efficient implementation of gamma). The chi comparison between measured and calculated doses for the five control points using criteria of 3% and 3mm revealed an average of 88.7% of all pixels having χ<1. The agreement will improve when the measured portal images are corrected for flood field and support-arm backscatter effects. This approach allows us to obtain both the EPID dose and the phantom/patient dose. These preliminary results demonstrate promising accuracy. With further improvements, this approach will be useful for benchmarking of time-resolved EPID dose applications intended for rotational IMRT QA and adaptive radiation therapy.
Continuous Crystallization (2013)

This chapter contains sections titled: Concept and Design of Continuous Crystallizers Various Continuous Crystallizers Periphery Special Features of the Process Adjustment of Suspension Densities References
Gold‐Catalyzed 1,2‐/1,2‐Bis‐acetoxy Migration of 1,4‐Bis‐propargyl Acetates: A Mechanistic Study (2012)

The late transition metal catalyzed rearrangement of propargyl acetates offers an interesting platform for the development of synthetically useful transformations. We have recently shown that gold complexes can catalyze a highly selective tandem 1,2-/1,2-bis-acetoxy migration in 1,4-bis-propargyl acetates to form 2,3-bis-acetoxy-1,3-dienes. In this way, (1Z,3Z)- or (1Z,3E)- and (1E,3Z)-1,3-dienes could be obtained in a stereocontrolled manner depending on the electronic and steric features of the ancillary ligand bound to gold and the substituents at the propargylic positions. In this work, we report an experimental study on the scope of this transformation, plus a detailed theoretical examination of the reaction mechanism, which has revealed the key features responsible for the reaction stereoselectivity. Synthetic applications towards the one-pot synthesis of quinoxaline heterocycles and tandem Diels-Alder processes have also been devised.
Noncontact Sleep Monitoring With Infrared Video Data to Estimate Sleep Apnea Severity and Distinguish Between Positional and Nonpositional Sleep Apnea: Model Development and Experimental Validation (Preprint) (2020)

<sec> <title>BACKGROUND</title> Sleep apnea is a respiratory disorder characterized by frequent breathing cessation during sleep. Sleep apnea severity is determined by the apnea-hypopnea index (AHI), which is the hourly rate of respiratory events. In positional sleep apnea, the AHI is higher in the supine sleeping position than it is in other sleeping positions. Positional therapy is a behavioral strategy (eg, wearing an item to encourage sleeping toward the lateral position) to treat positional apnea. The gold standard of diagnosing sleep apnea and whether or not it is positional is polysomnography; however, this test is inconvenient, expensive, and has a long waiting list. </sec> <sec> <title>OBJECTIVE</title> The objective of this study was to develop and evaluate a noncontact method to estimate sleep apnea severity and to distinguish positional versus nonpositional sleep apnea. </sec> <sec> <title>METHODS</title> A noncontact deep-learning algorithm was developed to analyze infrared video of sleep for estimating AHI and to distinguish patients with positional vs nonpositional sleep apnea. Specifically, a 3D convolutional neural network (CNN) architecture was used to process movements extracted by optical flow to detect respiratory events. Positional sleep apnea patients were subsequently identified by combining the AHI information provided by the 3D-CNN model with the sleeping position (supine vs lateral) detected via a previously developed CNN model. </sec> <sec> <title>RESULTS</title> The algorithm was validated on data of 41 participants, including 26 men and 15 women with a mean age of 53 (SD 13) years, BMI of 30 (SD 7), AHI of 27 (SD 31) events/hour, and sleep duration of 5 (SD 1) hours; 20 participants had positional sleep apnea, 15 participants had nonpositional sleep apnea, and the positional status could not be discriminated for the remaining 6 participants. AHI values estimated by the 3D-CNN model correlated strongly and significantly with the gold standard (Spearman correlation coefficient 0.79, &lt;i&gt;P&lt;/i&gt;&amp;lt;.001). Individuals with positional sleep apnea (based on an AHI threshold of 15) were identified with 83% accuracy and an F1-score of 86%. </sec> <sec> <title>CONCLUSIONS</title> This study demonstrates the possibility of using a camera-based method for developing an accessible and easy-to-use device for screening sleep apnea at home, which can be provided in the form of a tablet or smartphone app. </sec>
<title>Multiple diode laser polygon raster output scanner design</title> (1997)

The usual xerographic polygon raster output scanner (ROS) design is a set of compromises among speed, image quality, reliability and cost. The design solution presented here pushes the ROS print speed and quality boundaries well beyond the desktop printer while keeping cost low. A dual diode laser source is used to simultaneously write two high resolution, high contrast scan lines that are offset in the cross-scan plane in an underfilled polygon embodiment. The benefits of a dual diode laser design are the high print rate with a low motor polygon assembly (MPA) speed; each beam power is half of that required of a single source; and the electronic data transfer rates are reduced by a factor of two. As the number of sources increases clearly so do these benefits. Reliable and cost effective MPA speeds are limited to less than 30,000 rpm. Multiple diode laser sources impose additional design constraints over single laser sources. The demanding image quality specifications of single laser ROS designs such as spot size and shape, wobble, bow and scan linearity must be achieved while managing new, multiple laser characteristics such as line separation and differential bow. Appropriate compromises of individual image quality parameters must always be made in order to achieve a system design that meets all of the image quality specifications over a reasonable depth of focus.
Microstructures and Mechanical Properties of Al3Ti/Al Composites Produced In Situ by High Shearing Technology (2018)

Due to its low density, high strength, and stiffness the intermetallic phase Al 3 Ti is a good candidate as reinforcement for Al alloys. In this work, in situ Al 3 Ti particle reinforced Al composites are fabricated from Ti particles and Al melt via melt stirring with a high shearing mixer. Microstructure and mechanical properties are investigated. The results indicate that, owing to the high shearing effect and intensive macroscopic flow of the melt, reinforced particles are distributed homogeneously on the microscopic and macroscopic scale. Furthermore, Al 3 Ti particles are proved to be effective nuclei for heterogeneous nucleation of α‐Al, thus the grain size of the Al matrix is significantly decreased. As a result of the fine grains and the uniform distribution of Al 3 Ti particles, E‐modulus, yield, and tensile strength of the composites are enhanced.