gebhart/patrepeval huggingface dataset:
Gene Transfer and Left Ventricular Remodeling (2005)

This chapter discusses specific transgenes that may be effective in attenuating or reversing left ventricular remodeling, and provides an in-depth analysis of adenylyl cyclase type VI. Revascularization and pharmacological therapy have been used successfully to attenuate the extent of adverse remodeling associated with cardiovascular diseases such as myocardial infarction and hypertension. In some instances, revascularization and pharmacological treatment can reverse deleterious left ventricular remodeling and improve cardiac function. In general, selecting a gene for gene transfer to treat a specific abnormality of cardiac function is based on data indicating that the endogenous levels of the selected gene are insufficient, or that the elaboration of the gene—even if foreign to the heart—will have a salutary effect. The choice of vector will depend on the cell type in the heart that is targeted for gene transfer Adenovirus and adeno-associated virus (AAV) are also suitable vectors, which can be used to obtain gene transfer in cardiac myocytes and other nondividing cells.
Piroxicam fails to reduce myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise (1996)

To test the hypothesis that delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of prostaglandin E(2) (PGE(2)), ten healthy male subjects were studied. Using a double-blind randomized crossover design, each subject performed two isokinetic tests separated by a period of at least 6 weeks: once with placebo, and once with piroxicam (Feldene((R))). They were given one capsule containing either placebo or piroxicam (20 mg) per day for 6 days with initial doses given starting 3 days prior to isokinetic testing. Exercise consisted of eight stages of five maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases, on a Kin Trex device at 60( degrees )/s angular velocity. The subjective presence and intensity of DOMS were evaluated using a visual analogue scale immediately after, and 24 and 48 h after each test. The mean plasma concentration of PGE(2) measured at rest and after exercise was significantly lower in the group treated with piroxicam (p < 0.05). However, statistical analysis (two-way ANOVA test) revealed that exercise did not cause any significant change of mean plasma PGE(2) over time in either of the two groups. Eccentric work was followed by severe muscle pain in extensor and flexor muscle groups. Maximal soreness was noted 48 h postexercise. Serum creatine kinase activity and the serum concentration of myoglobin increased significantly, and reached peak values 48 h after exercise in both experimental conditions (p < 0.001). By paired t-test, it appeared that there were no significant differences in the serum levels of these two markers of muscle damage between the two groups at any time point. We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results.
MoireGraphs: radial focus+context visualization and interaction for graphs with visual nodes (2004)

Graph and tree visualization techniques enable interactive exploration of complex relations while communicating topology. However, most existing techniques have not been designed for situations where visual information such as images is also present at each node and must be displayed. This paper presents MoireGraphs to address this need. MoireGraphs combine a new focus+context radial graph layout with a suite of interaction techniques (focus strength changing, radial rotation, level highlighting, secondary foci, animated transitions and node information) to assist in the exploration of graphs with visual nodes. The method is scalable to hundreds of displayed visual nodes.
Induction of protective immunity against Schistosoma mansoni by a non‐living vaccine. VI. Antigen recognition by non‐responder mouse strains (1988)

Previous studies have shown that many strains of mice develop partial resistance to Schistosoma mansoni as a result of intradermal vaccination with soluble schistosome antigens plus BCG. However, P and BALB/c mice are non-responsive to this intradermal vaccination protocol. In this study, humoral and cellular responses to schistosome antigens in vaccinated P and BALB/c mice were compared to those in protected C57BL/6 mice to identify an immune correlate to resistance in this model. Levels of circulating IgG and IgM antibodies to soluble adult worm antigens, as measured by ELISA, were comparable between strains. Moreover, Western blot analysis revealed no qualitative differences in antibody reactivity, with sera from vaccinated animals of all three strains recognizing the antigen previously identified as Sm-97 (paramyosin). However, vaccinated P and BALB/c mice showed specific defects in cell-mediated immunity to schistosome antigens, including decreased production of macrophage-activating lymphokines and an inability to produce activated macrophage effector cells in vivo at the site of antigen challenge. These observations strengthen our hypothesis that the intradermal vaccine acts through induction of T-cell-mediated immune resistance mechanisms.
Теоретическое определение деформационной составляющей коэффициента трения при взаимодействии наноструктурированных поверхностей (2014)

Up to now there is no consensus within which theoretical models can be evaluated and divide experimentally values of the two additive parts of the coefficient of friction adhesive (molecular) and deformation (mechanical) components. For the first time, for roughness simulated by prismatic rods with one-dimensional probability density the deformation (mechanical) component of friction was described through bending of prismatic bars of roughness which simulating the interaction with each other. Also for the first time, a formula that relates the deformation coefficient of friction with the depth of mutual penetration of two plane roughness of the interacting surfaces.
Automatic recognition of continuously spoken sentences from a finite state grammer (2005)

We report performance results on the recognition of continuously spoken sentences from the finite state grammar for the "New Raleigh Language" (vocabulary-250 words; average sentence length-8 words; entropy-2.86 bits/word; perplexity-7.27 words). Sentence and word error rates of 5% and 0.6% , respectively, are achieved, using a new centisecond-level model for the acoustic processor. We also report results for the "CMU-AIX05 Language" (vocabulary-1011 words; average sentence length-about 7 words; entropy-2.18 bits/word; perplexity-4.53 words), using both our earlier phone-level model and the centisecond-level model. With the phone-level acoustic-processor model, sentence and word error rates of 2% and 0.8%, respectively, are achieved. With the centisecond-level model, sentence and word error rates are 1% and 0.1%, respectively.
A waveguide filter bank for millimeter-wave spectroscopy (2014)

We present the design concept and our latest simulation results for a novel low (R~100) to moderate (R~1000) resolution multi-pixel direct detection spectrometer operating at millimeter (mm) and submillimeter (submm) wavelengths. This design implements a transmission line filter bank using rectangular waveguide resonant cavities as a series of frequency filters, each terminated by a lumped-element kinetic inductance detector (LEKID).
Estrogen-induced microsatellite DNA alterations are associated with Syrian hamster kidney tumorigenesis (1998)

Exposure to estrogens is associated with an increase in cancers, including malignancies of the breast and uterus in humans, and of the kidney in hamsters. DNA damage induced by metabolic activation of estrogen has been postulated to result in gene mutations critical for the development of estrogen-induced kidney tumors in hamsters. As part of our examination of the genetic consequences of estrogen-induced DNA damage, we searched for estrogen-induced alterations in microsatellite DNA, a frequent site of mutation in tumors. Genomic DNA isolated from kidney of hamsters treated with estradiol, from estrogen-induced kidney tumors and from untreated age-matched controls, was examined by Southern blot analysis with three multi-locus oligonucleotide probes: (GACA)4, (CAC)6 and (CAG)6. Alterations in DNA fragments containing GACA and CAC tandem repeats were detected in kidney DNA of hamsters treated with hormone for 3 and 4 months, whereas no such effects were seen in control animals. In estrogen-induced tumors, microsatellite alterations were observed in fragments that contain these same two repeat sequences and also CAG repeat sequences. The induction of microsatellite alterations by estradiol in kidney DNA preceding estrogen-induced renal malignancy may play a role in hormone-induced tumorigenesis.
Sweet Control: MicroRNA Regulation of the Glycome (2019)

Glycosylation is a sophisticated informational system that controls specific biological functions at the cellular and organismal level. Dysregulation of glycosylation may underlie some of the most complex and common diseases of the modern era. In the past 5 years, microRNAs have come to the forefront as a critical regulator of the glycome. Herein, we review the current literature on miRNA regulation of glycosylation and how this work may point to a new way to identify the biological importance of glycosylation enzymes.
A Coiled Carbon Nanotube Yarn-Integrated Surface Electromyography System To Monitor Isotonic and Isometric Movements (2022)

A surface electromyogram (sEMG) electrode collects electrical currents generated by neuromuscular activity by a noninvasive technique on the skin. It is particularly attractive for wearable systems for various human activities and health care monitoring. However, it remains challenging to discriminate EMG signals from isotonic (concentric/eccentric) and isometric movements. By applying nanotechnology, we provide a coiled carbon nanotube (CNT) yarn-integrated sEMG device to overcome sEMG-based motion recognition. When the arm was contracted at different angles, the sEMG-derived root mean square amplitude signals were constant regardless of the angle of the moving arm. However, the coiled CNT yarn-derived open circuit voltage (OCV) signals proportionally increased when the arm's angle increased, and presented negative and positive values depending on the moving direction of the arm. Moreover, isometric contraction is characterized by the onset of EMG signals without an OCV signal, and isotonic contraction is determined by both EMG signals and OCV signals. Taken together, the integration of EMG and coiled CNT yarn electrodes provides complementary information, including the strength, direction, and degree of muscle movement. Therefore, we suggest that our system has high potential as a wearable system to monitor human motions in industrial and human system applications.
Modelling a Multi-car Elevator System using Witness (2013)

Elevators are considered a necessity in buildings with multiple floors. In tall buildings there is a need for efficient control of the elevator system in order to obtain satisfactory service levels. To achieve an efficient elevator control strategy a variety of diverse and sometimes conflicting constraints has to be resolved. To investigate the effectiveness of a vertical transportation system, we have developed a simulation model to analyze the call strategy of a multi-car elevator system. In this paper the main steps in the methodology for modelling elevator performance and passenger traffic in a public building are explained. Elevator dynamics and control, call allocation and passenger traffic modelling are described resulting in a Witness model. Witness simulation software has been used as a test-bed for model building, simulation and experimentation. Three different strategies were devised and experimented on the model and the results were compared to find the best average waiting time. Results indicate that the average waiting time of passengers was slightly improved when using the shortest distance strategy. In addition to passenger waiting time it has been realised that elevator performance depends on the passenger traffic patterns and, during heavy traffic, service level is greatly affected by the call allocation algorithm. The research concludes with the need to carefully select the data set as the basis for simulation comparisons.
A new view of intellectual property and software (1996)

article Free Access Share on A new view of intellectual property and software Authors: Randall Davis Professor of Computer Science at MIT and associate director of MIT's Artificial Intelligence Laboratory. Professor of Computer Science at MIT and associate director of MIT's Artificial Intelligence Laboratory.View Profile , Pamela Samuelson Visiting professor of law at Cornell Law School Visiting professor of law at Cornell Law SchoolView Profile , Mitchell Kapor Adjunct Professor of Media Arts and Sciences at MIT Adjunct Professor of Media Arts and Sciences at MITView Profile , Jerome Reichman Professor of law in the field of contracts and intellectual property, Vanderbilt University. Professor of law in the field of contracts and intellectual property, Vanderbilt University.View Profile Authors Info & Claims Communications of the ACMVolume 39Issue 3March 1996 pp 21–30https://doi.org/10.1145/227234.227237Published:01 March 1996Publication History 15citation2,305DownloadsMetricsTotal Citations15Total Downloads2,305Last 12 Months60Last 6 weeks13 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Common Variants Related to Serum Uric Acid Concentrations Are Associated with Glucose Metabolism and Insulin Secretion in a Chinese Population (2015)

Our results indicated that the uric acid-associated genes have an impact on the risk of T2D, glucose metabolism and insulin secretion in a Chinese population.
Formation of Uniform Mesopores in ZSM-5 Zeolite through Treatment in Alkaline Solution (2000)

Abstract Treatment of ZSM-5 in alkaline solution dramatically changes morphology of the ZSM-5, leading to the formation of mesopores whose size is almost uniform without destruction of microporous structure.
CPG treatment selectively prevents Treg-mediated suppression of adaptive immunity and improves outcome from sepsis post-injury (2007)

MacConmara, Malcolm MB BCh; Fujimi, Satoshi MD; McKenna, Ann MB BCh; Lapchak, Peter PhD; Stallwood, Christopher BSc; Tajima, Goro MD; Delisle, Adam BSc; Mannick, John MD; Lederer, James PhD Author Information
Designing optical path length, photonic, and plasmonic effects into nanostructured solar cells (2011)

The numerical modeling presented here shows the carrier collection and light management potential of nano-scale structure designs in solar cells. This design evaluation procedure includes scattering phenomena arising from photonic (periodic structure) and plasmonic effects and also the effective absorber length impact arising from morphology. This design work points to short circuit current densities of over 17mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> being attainable under AM1.5G from an a-Si:H absorber nominal thickness of 200nm.
Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice (2000)

The synthetic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin upregulates eNOS in thrombocytes, decreases platelet activation in vivo, and protects from cerebral ischemia in normocholesterolemic mice. Antithrombotic and stroke-protective effects of statins are mediated in part by eNOS upregulation. Our results suggest that statins may provide a novel prophylactic treatment strategy independent of serum cholesterol levels.
The Gelation of Sodium Silicate. Effect of Sulfuric Acid, Hydrochloric Acid, Ammonium Sulfate, and Sodium Aluminate. (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Gelation of Sodium Silicate. Effect of Sulfuric Acid, Hydrochloric Acid, Ammonium Sulfate, and Sodium Aluminate.Reynold C. Merrill and Robert W. SpencerCite this: J. Phys. Chem. 1950, 54, 6, 806–812Publication Date (Print):June 1, 1950Publication History Published online1 May 2002Published inissue 1 June 1950https://doi.org/10.1021/j150480a009RIGHTS & PERMISSIONSArticle Views1279Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (377 KB) Get e-Alerts
Measuring atrophy in Alzheimer disease (2005)

In short-interval studies, using the ventricular boundary shift integral instead of the brain boundary shift integral may allow for disease-modifying effects to be demonstrated using significantly smaller sample sizes. This potential benefit must be balanced against the possibility that ventricular volumes may be more likely to be affected by factors other than neurodegeneration.
Fast and flexible word searching on compressed text (2000)

We present a fast compression technique for natural language texts. The novelties are that (1) decompression of arbitrary portions of the text can be done very efficiently, (2) exact search for words and phrases can be done on the compressed text directly, using any known sequential pattern-matching algorithm, and (3) word-based approximate and extended search can also be done efficiently without any decoding. The compression scheme uses a semistatic word-based model and a Huffman code where the coding alphabet is byte-oriented rather than bit-oriented. We compress typical English texts to about 30% of their original size, against 40% and 35% for Compress and Gzip , respectively. Compression time is close to that of Compress and approximately half of the time of Gzip , and decompression time is lower than that of Gzip and one third of that of Compress . We present three algorithms to search the compressed text. They allow a large number of variations over the basic word and phrase search capability, such as sets of characters, arbitrary regular expressions, and approximate matching. Separators and stopwords can be discarded at search time without significantly increasing the cost. When searching for simple words, the experiments show that running our algorithms on a compressed text is twice as fast as running the best existing software on the uncompressed version of the same text. When searching complex or approximate patterns, our algorithms are up to 8 times faster than the search on uncompressed text. We also discuss the impact of our technique in inverted files pointing to logical blocks and argue for the possibility of keeping the text compressed all the time, decompressing only for displaying purposes.
Application of object-oriented technology for integrating heterogeneous database systems (1995)

Article Application of object-oriented technology for integrating heterogeneous database systems Share on Author: Bhavani Thuraisingham The MITRE Corporation, Burlington Road, Bedford, MA The MITRE Corporation, Burlington Road, Bedford, MAView Profile Authors Info & Claims CSC '95: Proceedings of the 1995 ACM 23rd annual conference on Computer scienceFebruary 1995 Pages 216–221https://doi.org/10.1145/259526.259557Online:27 February 1995Publication History 0citation547DownloadsMetricsTotal Citations0Total Downloads547Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Flapping viscosity probe that shows polarity-independent ratiometric fluorescence (2017)

Flapping fluorophores (FLAP) have been developed as a new series of molecular viscosity probes that show polarity-independent ratiometric fluorescence properties.
A System for LogD Screening of 96-Well Plates Using a Water-Plug Aspiration/Injection Method Combined with High-Performance Liquid Chromatography−Mass Spectrometry (2007)

A system for screening of the octanol/water distribution coefficient (LogD) using automatic sampling of 96-well plates was developed. The high-speed assay for LogD (HSLogD) screening uses a water-plug aspiration/injection method combined with high-performance liquid chromatography-mass spectrometry (HPLC-MS). The method is useful for LogD analysis of highly hydrophobic compounds, where the concentration of the compound in the octanol phase is much higher than that in the water phase. In the case of LogD analyses, the conventional shake-flask method has been widely used, but it is difficult to increase the throughput of the shake-flask method because the lower water phase is carefully separated by manual separation without contamination of the upper octanol phase. We attempted to develop an automatic sampling method instead of manual separation to increase the throughput of the measurement. In initial attempts at automatic sampling, contamination of the octanol phase occurred when sampling of the water phase was made. This was because the octanol phase entered the sampling needle as it passed through to the lower water phase. This contamination was prevented by taking up a few microliters of water into the needle as a plug before sampling of the water phase (the water-plug aspiration/injection method). LogD values of some common drugs measured using the HSLogD agreed with reported LogD values (0 < LogD < 5).
Oxidized Mild Steel S235: An Efficient Anode for Electrocatalytically Initiated Water Splitting (2015)

The surface of steel S235 was oxidized by Cl2 gas and checked for its electrocatalytic efficiency regarding oxygen formation in aqueous solution. If exposed to humid Cl2 gas for 110 min, steel S235 became an electrocatalyst that exhibits an overpotential for the oxygen evolution reaction (OER) of 462 mV at 1 mA cm(-2) at pH 7. The OER activity of the same sample at pH 13 was moderate (347 mV overpotential at 2.0 mA cm(-2) current density) in comparison with OER electrocatalysts developed recently. Potential versus time plots measured at a constant current demonstrate the sufficient stability of all samples under catalysis conditions at pH 7 and 13 for tens of hours. High-resolution X-ray photoelectron spectra could be reasonably resolved with the proviso that Fe2 O3 , FeO(OH), MnO(OH), and Mn2 O3 are the predominant Fe and Mn species on the surface of the oxidized steel S235.