gebhart/patrepeval huggingface dataset:
Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations (2017)

Aging is associated with significant changes in hematopoiesis, including clonal dominance, anemia, myeloid malignancies, and reduced activation of signal transducer and activator of transcription 5 (Stat5). In previous studies, Stat5 deletion surprisingly amplified FLT3/ITD+ myeloid expansion or Myc-driven lymphoid expansion. Here we show that Stat5 deficiency has a strong impact upon transcriptional heterogeneity in single sorted c-Kit+Lin-Sca-1+ (KLS) cells or CD150+CD48- KLS long-term repopulating hematopoietic stem cells (LT-HSC). Single cell polymerase chain reaction (PCR) was performed on selected regulators of multi-lineage hematopoiesis. At least two dominant sub-populations were identified by increased expression of cell cycle regulatory and leukemia-associated genes. Furthermore, in the top expressing quartile of cells, the majority of genes were proportionally overrepresented. In wild-type KLS cells, Stat5 mRNA levels were also strongly correlated with several genes. Since heterogeneity decreases with age or inflammatory or oncogenic stress, these results provide a potential mechanistic linkage to Stat5 expression.
Implementation of a direct control algorithm for induction motors based on discrete space vector modulation (2000)

The basic concept of direct torque control of induction machines is investigated in order to emphasize the effects produced by a given voltage vector on stator flux and torque variations. The low number of voltage vectors which can be applied to the machine using the basic DTC scheme may cause undesired torque and current ripple. An improvement of the drive performance can be obtained using a new DTC algorithm based on the application of the space vector modulation (SVM) for prefixed time intervals. In this way a sort of discrete space vector modulation (DSVM) is introduced. Numerical simulations and experimental tests have been carried out to validate the proposed method.
Automated, rapid identification of bacteria by pattern analysis of growth inhibition profiles obtained with Autobac 1 (1977)

A scheme for identifying bacteria has been devised which utilizes the inhibition patterns obtained by Autobac 1 with routine and unusual antimicrobial agents and with other differentially inhibitory chemical compounds. Over 600 compounds were initially identified from the literature, and over 125 of these were selected for further testing on the basis of antibacterial activity most conducive to the instrument-generated differential scheme. Numerical growth index information derived by light scatter comparisons from the instrument were analyzed by computer, utilizing the quadratic discriminant function statistical technique. In comparison with conventional methods, accuracy for the 10 bacterial genera studied was 95% or greater. Results indicate a potential for both bacterial identification and antimicrobial agent susceptibility testing in the clinical laboratory within 3 to 5 h when using this automated approach.
Surgical immunology and the development of modern surgery (2013)

Surgery, as we know it today, could not have developed without the major achievements in immunobiology that have occurred during the last 150 years. Because of the relationship of immunobiology to transfusions, transplantation, wound healing, infection, cancer therapy and drug therapy, immunobiologic principles are employed in the treatment of virtually every surgical patient. It is the purpose of this paper to briefly review the early contributions that Dr. Renzo Dionigi made to this important field. Dr. Dionigi had his basic surgical training at the University of Pavia, then he came to Cincinnati in 1968 to work in the department of surgery with Dr. William A. Altemeier. He was promptly assigned to work in my laboratory where he did an outstanding job during the next two years, with major contributions in the field of immunobiology.
The platinum doped MOST: A memory storage element (1981)

The effect of diffused platinum on MOSFET's has been studied. The materials used were
Direct methods in protein electron crystallography – beef liver catalase in its fully hydrated form at room temperature (1999)

The crystal structure of beef liver catalase was determined ab initio in projection to 9 A resolution using electron diffraction data at room temperature from hydrated specimens maintained in an environmental chamber in the electron microscope. A conservative combination of symbolic addition with maximum entropy and likelihood led to a model with a Patterson correlation coefficient C = 0.89 to the observed data. This independent solution could then be compared favorably to a previous 23 A analysis of electron micrographs from frozen hydrated preparations. Prediction of the higher-resolution structure by extension of the lower-resolution image-based phase basis set also gave a good match to the direct-methods solution, particularly for the most intense reflections.
Organic–Inorganic Hybrid Nanoparticles via Photoinduced Micellation and Siloxane Core Cross-Linking of Stimuli-Responsive Copolymers (2013)

Photoacid-induced siloxane cross-linking of stimuli-responsive copolymer micelles allows the synthesis of well-defined organic-inorganic hybrid nanoparticles. Two conceptually different synthetic approaches are presented, both via photoinduced cross-linking of poly(4-hydroxystyrene-<i>block</i>-styrene) micelles and via <i>one-pot</i> photoacid-catalyzed micelle formation and siloxane cross-linking of poly(4-<i>tert</i>-butoxystyrene-<i>block</i>-styrene). The <i>multistep</i> synthetic route showed intermicellar cross-linking leading to agglomerates. In contrast to this, the formation of the nanoparticles via the one-pot synthesis yielded well-defined structures. The use of different siloxane cross-linking agents and their effects on the properties of the cross-linked micellar structures have been evaluated. Scanning electron microscopy and differential scanning calorimetry indicate rigid core cross-linked nanoparticles. Their size, molar mass, and swelling behavior were analyzed by dynamic and static light scattering. Cyclic siloxane cross-linking agents lead to residual C═C double bonds within the nanoparticle core that allow postsynthetic modification by, e.g., thiol-ene click reactions.
A Unified Online Deep Learning Prediction Model for Small Signal and Transient Stability (2020)

This paper proposes a novel unified prediction approach for both small-signal and transient rotor angle stability as opposed to other studies that have only addressed transient rotor angle stability. Deep learning techniques are employed in this paper to train an online prediction model for rotor angle stability (RAS) using the voltage phasor measurements which are collected across the entire system. As a result, the trained model provides a fast yet accurate prediction of the transient stability status when a power system is subjected to a disturbance. Also, if the system is transiently stable, the prediction model updates the power system operator concerning the damping of low-frequency local and inter-area modes of oscillations. Therefore, the presented approach provides information concerning the transient stability and oscillatory dynamic response of the system such that proper control actions are taken. To achieve these objectives, advanced deep learning techniques are employed to train the online prediction model using a dataset which is generated through extensive time domain simulations for wide range of operating conditions. A convolutional neural network (CNN) transient stability classifier is trained to operate on the transient response of the phasor voltages across the entire system and provide a binary stability label. In tandem, a long-short term memory (LSTM) network is trained to learn the oscillatory response of a predicted stable system to capture the step-by-step dynamic evolution of the critical poorly damped low-frequency oscillations. The superior performance of the proposed model is tested using the New-England 10-machine, 39-bus, IEEE 16-machine, 68-bus, 5-area and IEEE 50-machine, 145-bus test systems and is verified with time domain simulation.
Oxygenation of4-Alkoxyl Groups inAlkoxybenzoic Acidsby Polyporus dichrous (1974)

and3-ethoxy-4-isopropoxybenzyl alcohol). Some ethers (e.g., tri-O-methyl gallic acidandglycerol-a- [4-carboxy-2ethoxyphenyl]-ether) were notaffected. Thedealkylations andhydroxylations indicate thatthefungus hasa relatively nonspecific mechanism foroxygenating various 4-alkoxyl groupsofalkoxybenzoic acids; no evidence foroxygenation of 3-alkoxyl groupswas obtained. Hydroxylation products weregenerally degraded further, probably viadealkylation. Thevanillic acid and3-ethoxy-4-hydroxybenzoicacidformedbydealkylations were readily metabolized. Although the isopropyl ether ofsyringic acid was hydroxylated to2-(4-carboxy-2, 6-dimethoxyphenoxy)-propane-1-ol, neither thiscompound nor theparentisopropyl ether was dealkylated; syringic aciditself was onlyslowly andincompletely metabolized. Therelationship ofthese results tolignin degradation isdiscussed. Wood-destroying basidiomycetes orascomycetesthatdecompose lignin (white-rot fungi) cleave alkyl-aryl ether linkages incertain lowmolecular weight compounds related to structural elements inlignin. Thusvanillic acid (I)isdealkylated toprotocatechuic acid(II) by Polyporus vesicolor (3,8),andvarious 3,4dimethoxyphenyl compounds arepara-demethylated byFomesfomentarius to4-hydroxy-3methoxyphenyl compounds: e.g., veratric acid (III) isconverted tovanillic acid(I)(14). Higher alkyl ethers havenotbeeninvestigated, with theexception ofa-glycerol ethers ofguaiacol, whichhavebeenselected forstudy because of theimportance ofglycerol-fl-aryl ether structuresinlignin. Thereareconflicting reports aboutthemetabolism oftheglycerol ethers; someauthors havepresented evidence thatthis ether linkage insuchcompounds asguaiacyl
The effect of the cation alkyl chain length on density and diffusion in dialkylpyrrolidinium bis(mandelato)borate ionic liquids (2014)

The physicochemical properties of ionic liquids are strongly affected by the selective combination of the cations and anions comprising the ionic liquid. In particular, the length of the alkyl chains of ions has a clear influence on the ionic liquid's performance. In this paper, we study the self-diffusion of ions in a series of halogen-free boron-based ionic liquids (hf-BILs) containing bis(mandelato)borate anions and dialkylpyrrolidinium cations with long alkyl chains CnH2n+1 with n from 4 to 14 within a temperature range of 293-373 K. It was found that the hf-BILs with n = 4-7 have very similar diffusion coefficients, while hf-BILs with n = 10-14 exhibit two liquid sub-phases in almost the entire temperature range studied (293-353 K). Both liquid sub-phases differ in their diffusion coefficients, while values of the slower diffusion coefficients are close to those of hf-BILs with shorter alkyl chains. To explain the particular dependence of diffusion on the alkyl chain length, we examined the densities of the hf-BILs studied here. It was shown that the dependence of the density on the number of CH2 groups in long alkyl chains of cations can be accurately described using a "mosaic type" model, where regions of long alkyl chains of cations (named 'aliphatic' regions) and the residual chemical moieties in both cations and anions (named 'ionic' regions) give additive contributions. Changes in density due to an increase in temperature and the number of CH2 groups in the long alkyl chains of cations are determined predominantly by changes in the free volume of the 'ionic' regions, while 'aliphatic' regions are already highly compressed by van der Waals forces, which results in only infinitesimal changes in their free volumes with temperature.
Campus Space Management Using a Mobile BIM-based Augmented Reality System (2017)

In South Korea, the changing paradigm of family composition toward single-person households and nuclear families has caused the decrease in number of students, which has led to the need for change in the qualitative, rather than quantitative, management of spaces and facilities on university campuses. In particular, since 2005, the merging of universities have accelerated, which has brought up the need for a system that facilitates the management of integrated university systems. Accordingly, universities now require efficient system operation based on three-dimensional and data visualization, unlike the document-based management of facilities and spaces in the past.Â Users lack a sense of responsibility for public facilities, causing difficulties such as energy waste and frequent movement, as well as damage and theft of goods.Â This study aims to form an AR-based interface using the ANPR algorithm, a computer vision technique, and the position-based data of the GPS. It also aims to build a campus space management system to overcome the limitations of current systems and to effectively and systematically manage integrated building data. In addition, for module test verification, the prototype is applied to actual campus spaces, and additional demands for campus space management in the AR application are identified and organized.
Transcriptional regulation of the heat-shock response: a plant perspective (1991)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTTranscriptional regulation of the heat-shock response: a plant perspectiveWilliam B. Gurley and Joe L. KeyCite this: Biochemistry 1991, 30, 1, 1–12Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/bi00215a001https://doi.org/10.1021/bi00215a001research-articleACS PublicationsRequest reuse permissionsArticle Views203Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhancement of Moloney Sarcoma Virus-Induced Tumor Growth by Concanavalin A (1975)

Adult mice injected intraperitoneally with concanavalin A (con-A) commencing with the onset of 6mm. Moloney sarcoma virus (MSV)-induced tumors showed a marked enhancement of tumor growth compared to untreated control mice; whereas, treatment with con-A beginning on day 0 relative to MSV inoculation had no effect. Antibody production as measured by indirect membrane fluorescence was not affected by con-A. Since in vivo administered con-A has a specific suppressive effect on T-lymphocytes it is suggested that the primary immunologic response to MSV antigens is a function of T-cells.
Biosynthesis of Gastrokine-2 in the Human Gastric Mucosa: Restricted Spatial Expression along the Antral Gland Axis and Differential Interaction with TFF1, TFF2 and Mucins (2007)

Maturation of antral SMCs occurs stepwise via trans-differentiation of TFF3 expressing progenitor cells. The TFF1-GKN2 heterodimer and TFF2 differ characteristically by their binding to gastric mucins. This points to different physiological functions of TFF1 and TFF2, the latter maybe acting as a 'link peptide' for stabilization of the gastric mucus.
Emerging Applications of Gene Transfer in the Hematopoietic Cancers (1997)

Despite their undisputed contributions to our knowledge of the hematopoietic cancers, gene transfer studies have been limited by the quality of vector technologies. As transduction efficiencies and gene regulatory mechanisms improve, gene transfer can be expected to evolve into a major therapeutic modality in its own right.
Expression and presentation of endogenous mouse mammary tumor virus superantigens by thymic and splenic dendritic cells and B cells (1996)

Tolerance against superantigens (SAgs) encoded by endogenous mouse mammary tumor virus (Mtv) loci involves the intrathymic deletion of SAg-reactive T cells expressing a particular TCR V beta-chain, presumably upon presentation of the SAg by specialized APC. However, although the role of dendritic cells (DC) in the induction of tolerance against conventional Ags has been demonstrated, little is known about the role played by DC in tolerance induction against Mtv SAgs. Moreover, there is conflicting evidence concerning the capacity of DC to express and present Mtv SAgs. In this report we have analyzed the expression of Mtv SAgs in highly purified thymic and splenic DC and B cells by reverse transcriptase-PCR, using primers amplifying Mtv SAg-specific spliced mRNAs. DC express Mtv SAgs at levels comparable to B cells, but display a differential expression pattern of the various Mtv loci compared with B cells. Furthermore, our results show that DC are able to induce the deletion of SAg-reactive thymocytes in an in vitro assay, indicating that Mtv SAgs are functionally expressed on the DC surface. Collectively, our data are consistent with the hypothesis that DC play a role in the induction of intrathymic tolerance to Mtv SAgs.
Biosoluble polymers for drug delivery (1980)

Abstract The immobilization of α‐chymotrypsin on periodate oxidized cellulose as a biocompatible carrier was investigated. The properties and release of the enzyme from the polymer were studied. It was found that after an initial spurt, the amount of the released enzyme attains a practically constant value and the released enzyme retains its activity and shows increased heat stability. Such systems may be useful for a slow delivery of drugs and enzymes in the body.
Correlated-Q learning (2003)

Bowling named two desiderata for multiagent learning algorithms: rationality and convergence. This paper introduces co~elated-Q learning, a natural generalization of Nash-Q and FF-Q that satisfies these criteria. NashoQ satisfies rationality, but in general it does not converge. FF-Q satisfies convergence, but in general it is not rational. Correlated-Q satisfies rationality by construction. This papers demonstrates the empirical convergence of correlated-Q on a standard testbed of general-sum Markov games.
Geothermal ORC Systems Using Large Screw Expanders (2014)

The HSV1-tk gene has been explored as a reporter and/or suicide gene in molecular imaging of gene expression. Gene therapy with HSV1-tk and the use of this gene as a marker have been applied in patients with various forms of cancer. However, the conditions for clinical gene therapy protocols have yet to be optimized. A method to monitor the activity of HSV-tk in vivo would be extremely useful to optimize clinical gene therapy protocols. Positron emission tomography (PET) with a suitable probe can offer information about both the extent of gene expression and its distribution, provided that an appropriate reporter gene is included in the therapeutic cassette. PET imaging provides higher resolution and sensitivity and allows noninvasive quantification of biological processes. Several radiolabeled pyrimidine (thymidine) and purine (acycloguanosine) derivatives have been developed as reporter probes for imaging of HSV-TK enzyme activity with PET. In this review, information on radiolabeling and PET imaging of HSV1-tk gene expression with various nucleoside analogues is presented.
Reduced leakage currents and possible charge carriers tuning in Mg-doped Ga0.6Fe1.4O3 thin films (2012)

Ga0.6Fe1.4O3 is predicted to be magnetoelectric with non zero magnetization at room temperature. However, in thin films, electric properties are overshadowed by strong leakage currents. In this Letter, we show that Mg doping in Ga0.6Fe1.4O3 thin films grown by pulsed laser deposition allows decreasing the leakage current density by four orders of magnitude and might simultaneously allow tuning the carriers’ nature. These results suggest the possibility to develop a new class of material exhibiting room temperature magnetization, tunable transport properties, and magnetoelectric properties.
On the current status of magnetorheological dampers: seismic protection of full-scale structures (1997)

Because of their mechanical simplicity, high dynamic range, low power requirements, large force capacity and robustness, magnetorheological (MR) fluid dampers have been shown to be semi-active control devices that mesh well with application demands and constraints to offer an attractive means of protecting civil infrastructure systems against severe earthquake and wind loading. Following an overview of the essential features of MR fluids, this paper discusses the current status of this new technology for seismic protection of structures, including presentation of recent laboratory studies employing a seismically-excited, scale-model building and preliminary analyses of a prototype full-scale MR damper.
Application of In-House Mortality Composting on Viral Inactivity of Newcastle Disease Virus (2008)

This paper summarizes the results from 3 simulated in-house catastrophic mortality composting experiments. Experiment 1 evaluated the impact of water-based foam mass depopulation on in-house composting of the carcasses and litter and showed that water-based foam improved windrow temperatures. Experiment 2 evaluated the impact of freezing samples on virus recovery from windrow compost tissue and the choice of tissue for virus sampling within the bird. Experiment 2 documented that freezing the samples had minimal impact on processing and that virus recovery was more consistent among inoculated breast meat than inoculated tracheas. Experiment 3 evaluated the impact of sawdust, straw, and sawdust-straw base layer litter material on in-house mortality composting. All litter materials were able to reach and maintain temperatures in excess of 60 degrees C for multiple days. No viral hemagglutination activity was observed after d 2 during any of the 3 experiments.