gebhart/patrepeval huggingface dataset:
Robotic perineal radical prostatectomy and pelvic lymph node dissection using a purpose‐built single‐port robotic platform (2016)

Objectives To describe the features of the novel, purpose‐built da Vinci model SP 1098 single‐port robotic platform and to describe a step‐by‐step approach for perineal prostatectomy and pelvic lymph node dissection in a cadaver model. Methods Three single‐port robotic radical perineal prostatectomies and two pelvic lymph node dissections were performed on three male cadavers to assess the feasibility of the SP 1098 da Vinci robotic platform. The steps in the procedure included division of the rectourethralis muscle, splitting of the levator ani muscles bilaterally, opening of Denonvilliers fascia with dissection of the seminal vesicles, apical dissection and urethral division, anterior and lateral dissection with ligation of prostatic pedicles, bilateral pelvic lymph node dissection, and creation of the new vesico‐urethral anastomosis. The main outcomes assessed were operating time per step, total operating time, intra‐operative complications and need for conversion to conventional or open techniques. Results No conversions were required. No intra‐operative complications were seen. The median (range) operating time for performing single‐port robotic radical perineal prostatectomy and pelvic lymph node dissection was 210 (180–240) min. Conclusions We have shown the feasibility and efficacy of a novel, purpose‐built robotic system in performing single‐port radical perineal prostatectomy and describe, for the first time, the feasibility of robotic perineal lymph node dissection. This single‐port system will facilitate single‐port applications and allow surgeons to perform major urological operations via a small, single incision while preserving triangulation and optics, and eliminating clashing between instruments. Future clinical studies are needed to support these encouraging outcomes.
THE DEVELOPMENT OF ROAD CONSTRUCTION MATERIAL SELECTION SYSTEM (RC-MSS) (2005)

This paper looks into the development of a prototype Road Construction Material Selection System (RC-MSS) which based on the outcome through interviewed to the pavement experts to obtain the appropriate material for each pavement layer under particular design conditions. Data collected from the experts would be analysis using nonparametric statistical method to determine the ranking of each pavement material alternative prior to the development of RC-MSS. RC-MSS is developed with a prototype of an expert system using written using programming tool Microsoft Visual Basic 6.0 according the framework from the system. With this tool, better road design can also be achieved and save more time in the initial stage of on material selection, before scrutiny to laboratory test. This software would be the pioneer and provide guidance to engineers and consultants.
Recognition, mining, synthesis and estimation (rmse) for large-scale visual data using multilinear models (2006)

In this dissertation, we show the power of multilinear models in recognition, mining, synthesis, and estimation (RMSE) for large-scale tensor visual data in computer vision and graphics. We develop novel algorithms based on multilinear models to efficiently explore the relationship of multiple factors within the data and investigate some challenging applications in object recognition, video mining, image-based rendering, and 3D scene modeling. In object recognition, we present a general framework for dimensionality reduction using Datum-as-Is representation. Our approach works directly on the multi-dimensional form of the data (matrix in 2D and tensor in higher dimensions). This helps exploit spatio-temporal redundancies with less information loss than traditional image-as-vector methods. In video mining, we propose a novel incremental subspace learning algorithm to handle large scale or streaming tensor data. The algorithm updates the subspace matrices with sequential loading of data to reduce computational and storage complexities. We apply our algorithm to human action categorization and efficient video words retrieval for texture synthesis. In image-based rendering, we describe a novel out-of-core algorithm for higher-order tensor approximation. Our approach can handle very large dataset, synthesize novel images efficiently, and control each mode of the high-order data to obtain realistic rendering effects. In 3D scene modeling, we model the observed surface radiance tensor as the tensor product of a light transport tensor, and illumination and texture matrices, such that we can simultaneously estimate the illumination and texture from given multiview images captured under a single illumination setting.
Low threshold current density and high-quantum-efficiency 980-nm cw QW laser (2000)

Theoretical and experimental investigation of 980nm quantum well ridge waveguide lasers suitable for pumping Er<SUP>3+</SUP> doped fiber amplifiers are carried out. The valence hole subbands, the TE and TM mode optical gains, and the radiative current density of the In<SUB>0.2</SUB>Ga<SUB>0.8</SUB>As/GaAs/GaAs strained quantum well lasing at 980 nm have been investigated using a 6 by 6 Hamiltonian model. A very low threshold current density is predicted. These theoretical results would be useful for the design and further performance improvements of the ternary InGaAs and quaternary InAlGaAs strained QW laser diodes. Mesa, stripe geometry and ridge waveguide three quantum wells lasers have fabricated from a graded index separate confinement heterostructure grown by molecule beam epitaxy. For a 4 micrometers wide and 1000micrometers long ridge waveguide laser, a cw threshold current of 12.5mA, the threshold current density of 313A/cm<SUP>2</SUP>, an external quantum efficiency of 0.31mW/mA and power slope efficiency of 0.37mW/mA per facet were obtained.
Involvement of human plasma angiotensin I-converting enzyme in the degradation of the haemoregulatory peptide N-acetyl-seryl-aspartyl-lysyl-proline (1993)

The degradation of N-Ac-Ser-Asp-Lys-Pro (AcSDKP), a negative regulator controlling the proliferation of the haematopoietic stem cell, by enzymes present in human plasma, has been investigated. Radiolabelled AcSD[4-3H]KP ([3H]AcSDKP, 1 mM) was completely metabolized in human plasma with a half-life of 80 min, leading exclusively to the formation of radiolabelled lysine. The cleavage of AcSDKP was insensitive to classical proteinase inhibitors including leupeptin, but sensitive to metalloprotease inhibitors. The degradation was completely blocked by specific inhibitors of angiotensin I-converting enzyme (ACE; kininase II; peptidyldipeptide hydrolase, EC 3.4.15.1), showing that the first step of the hydrolysis was indeed due to ACE. In dialysed plasma, the hydrolysis proceeded at only 17% of the maximal rate, whereas addition of 20 mM NaCl led to the recovery of the initial rate observed with normal plasma. Hydrolysis of AcSDKP by commercial rabbit lung ACE generated the C-terminal dipeptide Lys-Pro. Thus, ACE cleaves AcSDKP by a dipeptidyl carboxypeptidase activity. In fact the formation of Lys-Pro was observed when AcSDKP was incubated in human plasma in the presence of HgCl2. These results suggest that ACE is involved in the first limiting step of AcSDKP degradation in human plasma. The second step seems to be under the control of a leupeptin- and E-64-insensitive, HgCl2-sensitive plasmatic enzyme.
Absence of TRPV4 Channels Improves Cardiac Function and Remodeling Following Myocardial Infarction and Transverse Aortic Constriction (2013)

Differentiation of cardiac fibroblasts (CF) into hypersecretory and contractile myofibroblasts during cardiac remodeling leads to increased extracellular matrix (ECM) deposition and contributes to diastolic dysfunction and eventual heart failure. Recently, our work has demonstrated that a mechanosenstive ion channel, TRPV4, is involved in mediating CF differentiation into myofibroblasts, by integrating mechanical and soluble signals in vitro . In the present study we investigated the physiological significance of TRPV4 during in vivo cardiac remodeling. Wild type (WT) and TRPV4 null mice were subjected to either myocardial infarction (MI) by ligating the left anterior descending (LAD) artery or pressure overload by transverse aortic constriction (TAC). Cardiac function was analyzed by 2D and PW Doppler echocardiography while cardiac fibrosis was measured using picrosirius red staining. We found that while survival rates are unchanged in MI animals, TRPV4 null mice showed improved survival rate compared WT in mice subjected to TAC. In addition, ejection fraction was preserved in TRPV4 null mice exposed to both MI and TAC surgeries compared to WT mice and fibrosis was attenuated in the TRPV4 null hearts as well. Our findings thus suggest that the absence of TRPV4 channels improves cardiac function and remodeling following myocardial injury.
Processing and Microstructure of WC-CO Cermets by Laser Engineering Net Shaping (2008)

Submicron-sized tungsten carbide-cobalt (WC-Co) powder and nanostructured WC-Co powder were applied to make thick wall samples by the Laser Engineered Net Shaping (LENS®) process. It was found that decomposition and decarburization of WC was limited during laser deposition because of the features of the LENS® process: high cooling rate, short heating time, and low oxygen concentration. The effects of working distance, as well as laser power, powder feed rate, and traverse speed on microstructure were studied in this paper. Thermal behavior leading to the observed microstructures that result from the variations in the processing parameters was investigated in detail
III–Nitride Epitaxy on Atomically Controlled Surface of Sapphire Substrate with Slight Misorientation (2012)

The importance of the atomically well-controlled surface of sapphire substrate with slight misorientation and ideally minimized surface roughness for III–nitride epitaxy is discussed in detail. An atomically controlled surface of sapphire substrate with slight misorientation angle is modeled and an almost ideal level of atomic surface roughness of sapphire substrate is found to be obtained by a chemical mechanical polishing (CMP) with colloidal silica. Cathodoluminescence (CL) imaging indicated the complete absence of subsurface damage induced by mechanical polishing. GaN and AlN thin films are grown on misoriented sapphire substrate with an atomically controlled surface by the CMP to investigate the misorientation angle of both sapphire and grown GaN and AlN thin films. An interface model is proposed to explain the difference in misorientation angle between sapphire and III–nitride thin films, providing strong evidence of the necessity of atomically controlled surface of sapphire substrate for III–nitride epitaxy.
Ultra-thin TiN/Ta/sub 2/O/sub 5W capacitor technology for 1 Gbit DRAM (2002)

A highly reliable Ta/sub 2/O/sub 5/ (1.6 nm SiO/sub 2/ equivalent thickness) capacitor with TiN/Ta/sub 2/O/sub 5/W structure is developed for 1 Gbit DRAMs. This Ta/sub 2/O/sub 5/ capacitor formed on the enlarged area electrode achieves a cell capacitance of 30 fF with 0.6 /spl mu/m-height storage-node in a area of 0.24 /spl mu/m/sup 2/. The critical steps in this technology are using of tungsten (W) for the storage-node surface, oxygen-plasma annealing after Ta/sub 2/O/sub 5/ film deposition, and a hemi-spherical grained (HSG) Si before W film deposition. This 1.6 nm SiO/sub 2/ equivalent thick Ta/sub 2/O/sub 5/ capacitor on HSG Si structure is realized at half of 1.5 V operation voltage with 10/sup -8/A/cm/sup 2/ leakage current density.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Resident memory CD8 + T cells in the upper respiratory tract prevent pulmonary influenza virus infection (2017)

Nasal epithelial tissue of the upper respiratory tract is the first site of contact by inhaled pathogens such as influenza virus. We show that this region is key to limiting viral spread to the lower respiratory tract and associated disease pathology. Immunization of the upper respiratory tract leads to the formation of local tissue-resident memory CD8<sup>+</sup> T cells (Trm cells). Unlike Trm cells in the lung, these cells develop independently of local cognate antigen recognition and transforming growth factor-β signaling and persist with minimal decay, representing a long-term protective population. Repertoire characterization revealed unexpected differences between lung and nasal tissue Trm cells, the composition of which was shaped by the developmental need for lung, but not nasal, Trm cells to recognize antigen within their local tissue. We show that influenza-specific Trm cells in the nasal epithelia can block the transmission of influenza virus from the upper respiratory tract to the lung and, in doing so, prevent the development of severe pulmonary disease. Our findings reveal the protective capacity and longevity of upper respiratory tract Trm cells and highlight the potential of targeting these cells to augment protective responses induced to respiratory viral vaccines.
Characterization and application of the enzyme peroxidase to the degradation of the mycotoxin DON (2017)

Deoxynivalenol (DON), one of the main mycotoxins found in food matrices, has high level of toxicity. This study aimed to characterize the peroxidase enzyme extracted from rice bran to be applied to the biodegradation of DON in order to evaluate the potential peroxidase (PO) from rice bran (RB) has to degrade DON in optimal conditions. Purification and recovery factors of PO extracted from RB and purified by three-phase partitioning were 5.7% and 50%, respectively. PO had the highest level of activity in the phosphate buffer 5 mM pH 5.5 in both crude and purified forms, whose reaction temperatures were 25°C and 10°C. At the end of production, purification and characterization steps, specific activities of the bran were 115.79 U mg<sup>-1</sup> and 4363 U g<sup>-1</sup>. Reduction in the mycotoxin DON in optimal conditions determined for PO from RB was 20.3%, a promising result when the aim is to adequate mycotoxicological levels to foods.
Design challenges in large-scale silicon photonics (2013)

We discuss the challenges in the design flow of complex silicon photonic circuits. The treatment of multi-physics, variability, parasitics at both layout and circuit level is not straightforward. Also, layout automation and verification will need significant developments on existing electronic and photonic design methods.
Transient Analysis of Serial Production Lines With Perishable Products: Bernoulli Reliability Model (2016)

Manufacturing systems with perishable products are widely observed in practice (e.g., food industry, biochemical productions, battery and semiconductor manufacturing). In such systems, the quality of the product is highly affected by its exposure time while waiting for the next operation, i.e., the residence time of intermediate parts within the system. Such a time should be strictly limited in order to ensure the product usability. The parts that reach the maximum allowable residence time need to be scrapped, thus impeding the production. To achieve an efficient production, the time-dependent or transient analysis is important to uncover the underlying principles governing production operations. In this paper, a serial production line model with two Bernoulli reliability machines, a finite buffer and perishable products is presented to analyze the transient behavior of such systems. The analytical formulas are derived to evaluate transient performance, and structural properties are investigated to study the effect of system parameters. In addition, using the model, we address problems of settling time estimation and production control to demonstrate the importance of the proposed method for transient analysis.
Fluorous interaction induced self-assembly of tobacco mosaic virus coat protein for cisplatin delivery (2018)

Tobacco mosaic virus coat protein was modified with a small molecular fluorous ponytail at specific sites, and self-assembled into spherical nanoparticles through fluorous interaction induced self-assembly. By loading the anti-cancer drug cisplatin through metal-ligand coordination, this spherical assembly with high stability has potential as a drug carrier.
Supplementary Figures 1-7, Table 1 from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants (2023)

&lt;p&gt;PDF file - 151K, Supplementary Figure 1 Different EML4-ALK variants elicit similar proliferation rates Supplementary Figure 2 ALK phosphorylation levels after inhibitor treatment Supplementary Figure 3 Schematic representation of EML4-ALK variants 1, 2, 3a and 3b Supplementary Figure 4 TAE684 induced ALK protein degradation Supplementary Figure 5 Protein stability of EML4-ALK variants Supplementary Figure 6 HSP90 inhibitor sensitivity of EML4-ALK variants 2 and 3a Supplementary Figure 7 Bortezomib sensitivity of EML4-ALK variants&lt;/p&gt;
Unintentional Injuries in Childhood: Analysis and Recommendations (2000)

Lisa W. Deal, Deanna S. Gomby, Lorraine Zippiroli, Richard E. Behrman, Unintentional Injuries in Childhood: Analysis and Recommendations, The Future of Children, Vol. 10, No. 1, Unintentional Injuries in Childhood (Spring - Summer, 2000), pp. 4-22
Participation in an ambulatory e‐pharmacovigilance system (2010)

IVRS technology can be used to perform ambulatory e-pharmacovigilance for a broad spectrum of patients, particularly older individuals who may at particular risk for ADEs.
Quantification of regional functional improvement of infarcted myocardium after primary PTCA by contrast‐enhanced magnetic resonance imaging (2009)

We quantitatively demonstrated that time to p-PTCA treatment significantly influences regional functional recovery of infarcted myocardium at a 4-month follow-up.
ChemInform Abstract: O2 Activation by Nonheme Iron Complexes: A Monomeric Fe(III)‐Oxo Complex Derived from O2 (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthèse et étude de polysiloxanes fonctionnalisés (2001)

Grâce à leurs propriétés particulièrement intéressantes, les silicones sont des composés d'intérêt industriel. La fonctionnalisation des polysiloxanes offre de nombreuses possibilités d'applications pour les silicones. C'est pourquoi la synthèse d'oligosiloxanes diversement fonctionnalisés présente un intérêt grandissant actuellement. Avant d'aborder nos recherches dans ce domaine, nous nous sommes attachés à préciser l'importance de ces composés. La réaction d'hydrosilylation qui permet de préparer des chloro- ou alkoxysilanes fonctionnalisés, éléments de base des silicones, a d'abord été étudiée via l'utilisation du catalyseur de Speier et de celui de Karstedt en présence de nombreuses fonctions. Dans le cadre d'une optimisation des conditions réactionnelles, nous avons mis en évidence l'efficacité et la polyvalence de l'oxyde de platine comme nouveau catalyseur de cette réaction. Nous avons alors étudié l'étape suivante dans la synthèse des silicones : l'oligomérisation. Celle-ci se fait par hydrolyse de dialkoxysilanes pour obtenir des polysiloxanes fonctionnalisés de petite taille (oligosiloxanes). La structure des oligomères portant des fonctions amine a été étudiée par RMN 29Si et spectrométrie de masse, ce qui nous a permis de comparer les stabilités des oligomères synthétisés. Cependant, dans le cas de mélanges, il est difficile de contrôler la structure des produits obtenus. Nous avons donc tenté, pour y remédier, de développer une stratégie de synthèse des oligosiloxanes sur support solide. Enfin, une dernière partie est consacrée aux tests biologiques dans lesquels nous avons engagés certains oligomères. Un poly(N-(2-aminoéthyl)-3-aminopropyl-méthyl-siloxane) s'est ainsi révélé aussi efficace que le PEI pour la transfection in vitro. Nous avons également testé de nombreux polysiloxanes portant des fonctions acide hydroxamique dans le cadre d'une problématique d'inhibition de l'oxydation cellulaire par chélation du fer.
FUSION OF MORPHOLOGICAL AND TEXTURE FEATURES FOR HIGH RESOLUTION IMAGE CHANGE DETECTION (2011)

Timely and accurate detection of damage caused by natural disasters is extremely important for supporting better decision making during emergencies. For operational use, it is crucial to produce damage maps as soon as the postevent images are available. This is a key issue for civil governments who need a fast and preliminary overview of the epicentral area, quick information on the extension and distribution of damage, and an evaluation of infrastructure. New imaging systems such as the WorldView-2 and WorldView-1 satellites, characterized by sub-meter spatial resolution, are now providing more imaging capacity on top of existing platforms, such as QuickBird or IKONOS, which have been operating for years. A large amount of information is available, and therefore the need for fully automated change detection techniques is becoming extremely urgent. Fully automated methods should be robust to residual mis-registrations, shadows, and seasonal and meteorological effects. These effects combine to reduce the attainable accuracy in the damage map. Moreover, since commercial sensors frequently relax constraints on collection geometries in order to increase collection opportunities during natural disasters, automated techniques must be robust to changing image acquisition angles.