gebhart/patrepeval huggingface dataset:
Inexpensive Brazeless RF Accelerator (2017)

A simple, inexpensive way to manufacture a standard radio frequency (RF) driven particle accelerator is presented. The simplification comes from two innovations: utilization of LCLS gun - type RF design to avoid an expensive brazing process and copper plating of stainless steel that further reduces manufacturing cost. This is realized by a special structure design where accelerating structure cells are made out of copper plated stainless steel with knife edges and structure irises - copper disks acts also as gaskets for vacuum and RF seal. Besides the reduced cost, brazeless assembly allows integration of effective cooling and magnet optics elements into accelerator cells.
A Protein Complex Containing Mdm10p, Mdm12p, and Mmm1p Links Mitochondrial Membranes and DNA to the Cytoskeleton-based Segregation Machinery (2003)

Previous studies indicate that two proteins, Mmm1p and Mdm10p, are required to link mitochondria to the actin cytoskeleton of yeast and for actin-based control of mitochondrial movement, inheritance and morphology. Both proteins are integral mitochondrial outer membrane proteins. Mmm1p localizes to punctate structures in close proximity to mitochondrial DNA (mtDNA) nucleoids. We found that Mmm1p and Mdm10p exist in a complex with Mdm12p, another integral mitochondrial outer membrane protein required for mitochondrial morphology and inheritance. This interpretation is based on observations that 1) Mdm10p and Mdm12p showed the same localization as Mmm1p; 2) Mdm12p, like Mdm10p and Mmm1p, was required for mitochondrial motility; and 3) all three proteins coimmunoprecipitated with each other. Moreover, Mdm10p localized to mitochondria in the absence of the other subunits. In contrast, deletion of MMM1 resulted in mislocalization of Mdm12p, and deletion of MDM12 caused mislocalization of Mmm1p. Finally, we observed a reciprocal relationship between the Mdm10p/Mdm12p/Mmm1p complex and mtDNA. Deletion of any one of the subunits resulted in loss of mtDNA or defects in mtDNA nucleoid maintenance. Conversely, deletion of mtDNA affected mitochondrial motility: mitochondria in cells without mtDNA move 2-3 times faster than mitochondria in cells with mtDNA. These observations support a model in which the Mdm10p/Mdm12p/Mmm1p complex links the minimum heritable unit of mitochondria (mtDNA and mitochondrial outer and inner membranes) to the cytoskeletal system that drives transfer of that unit from mother to daughter cells.
Does body mass index influence survival of patients with idiopathic pulmonary fibrosis? (2018)

<b>Aim:</b> It has been reported that a high body mass index (BMI) is associated with better survival in patients with idiopathic pulmonary fibrosis (IPF). We aimed to find out whether body mass index influences survival of patients with idiopathic pulmonary fibrosis. <b>Methods:</b> We examined the relationship between BMI and survival in our cohort of patients with IPF. These patients were first seen in our clinic between May 2008 and January 2018. All had a diagnosis of IPF based on clinical assessment and high resolution CT scan; one third underwent a surgical lung biopsy. Height and body weight were ascertained at the first consultation. Survival analysis was performed using SPSS version 16. <b>Results:</b> We had data on 367 patients. The median age at first consultation was 66 years (range 39 to 97). There were 272 men and 95 women. At presentation, 6 were underweight (BMI &lt; 18.5), 79 were of normal weight (BMI 18.5 to 25), 165 were overweight (BMI 25 to 30) and 117 were obese (BMI &gt; 30). On Kaplan-Meier survival analysis, there was no significant difference in survival between these categories (p=0.75). <b>Conclusion:</b> The differences between the groups did not reach clinical significance. The graph suggests that being underweight is an adverse prognostic factor, but the number of such patients was very small. It also suggests that obesity may be marginally beneficial for the first four years but not thereafter.
Supplementary Figure Legends from Maximizing the Efficacy of MAPK-Targeted Treatment in <i>PTEN</i><sup>LOF</sup><i>/BRAF</i><sup>MUT</sup> Melanoma through PI3K and IGF1R Inhibition (2023)

&lt;p&gt;Supplementary figure legends.&lt;/p&gt;
Early disease progression in a phase I study of bortezomib (B), cetuximab (C), and intensity-modulated radiation therapy (IMRT) for squamous cell carcinoma of the head and neck (SCCHN). (2010)

2575 Background: Preclinical studies combining proteasome inhibitor B and epidermal growth factor receptor (EGFR) inhibitor C, or B and RT, provided evidence for anti-tumor and radiosensitizing activity. These observations provided a rationale for a first-in-human phase I study combining B with standard concurrent C and IMRT in patients with advanced SCCHN. Methods: Cohorts of patients with chemo +RT naive stage IV or recurrent SCCHN were treated with escalating doses of B, (0.7, 1.0 and 1.3 mg/m2), given IV twice weekly on days 1, 4, 8 + 11 every 3 weeks. B + C 400 mg/m2 was started 1 week before, followed by B + weekly C 250 mg/m2 concurrent with IMRT 2Gy/5 days per week to 70 Gy. Results: 6 patients with stage IV and 1 with recurrent neck SCCHN were accrued; 6 had oropharyngeal and 1 had a laryngeal primary. 3 patients each received B 0.7 or 1.0 mg/m2, without dose-limiting toxicities, and 1 patient treated with B 1.3 mg/m2 was taken off study in week 5 due to recurring Gr 2 infusion reaction to C and progressive disease (PD). Expected Gr 3 toxicities included radiation mucositis (4), dermatitis (4), and rash (1). The study was terminated after 5/6 of the previously untreated patients had PD within one year, 2 in the lung and 3 locoregionally, despite 5 having better prognosis oropharyngeal SCCHNs (3 testing HPV+ before and 2 testing p16+ at the site of PD). The patient with a laryngeal primary had a CR and remains disease-free >10 months, and 1 patient each with PD were salvaged by surgery, or cisplatin and RT. In SCCHN cells, B was found to inhibit C and RT-induced degradation of EGFR, and enhance ERK1/2 pathway signaling and cell survival. Conclusions: The combination of B, C, and IMRT was well tolerated but resulted in a median progression free survival of <12 mos, which compared unfavorably to 17 mos reported for C+RT. Translational studies reveal B unexpectedly prevents C+RT induced EGFR degradation, enhancing tumor prosurvival signaling and radioprotection. Supported by NIHIntramural Project ZIADC-000016 and Millennium Pharmaceuticals. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Millennium
Canadian teleoperated landmine detection systems. Part II: Antipersonnel landmine detection (2005)

Continuing with the description of the Canadian teleoperated mine detection systems, in this paper we will focus on systems developed primarily for antipersonnel (AP) landmine detection. The Articulated Robotic Scanner (ARS) is a system approach that uses a generic robotic device capable of automatically moving a landmine detection sensor over natural ground surfaces in a manner similar to an operator. Exploiting the cost efficiency of proven high sensitivity commercial-off-the-shelf sensors, such as the metal detectors widely employed by military and humanitarian deminers, the high-precision automation of the ARS can be utilized to provide a low cost and low weight scanning imaging sensor that can be carried on a small autonomous platform. Concurrent with the ARS project, Defence R&D Canada – Suffield has maintained an active programme in the development of portable AP landmine detection systems, a number of which will be described. Together, these projects inspired a more ambitious vision, the Canadian Sensor Integration Concept (CANSIC), which applies the successful multi-sensor landmine detection approach to a small autonomous vehicle, using complementary sensors designed for antipersonnel landmine detection. Using a high-mobility robotic platform, the envisioned system incorporates five separate technologies: two hyper-spectral cameras, thermal and visual/near infrared, along with a scanning sensor imaging system mounted on a purpose build articulated robotic scanner, working in conjunction with a nuclear imaging confirmation sensor. Designed to provide clearance options for areas off established roadways, the goal is not only to operate in all environments and conditions that a deminer is able to, but also to extend the demining capabilities of military commanders and humanitarian demining project managers to situations where there is a high probability of casualities.
Scene nudity level detection with deep nets (2016)

In this paper, we present an approach that can detect scene nudity level with high precision using different deep net configurations. For this purpose, a recent approach [1] which has intense and very deep convolution layers is used. During net modelling, we strive to obtain most successful net configuration by comparing different Dropout models and image sizes -64 × 64, 128 × 128-. Additionally, leveraging the generalization capability of Support Vector Machine (SVM), improvement on success rate is demonstrated by retraining the features obtained at different output levels of the nets with SVM. At test and training stages, scene is investigated under three nudity levels: regular, semi-nudity and full-nudity. In order to evaluate false alarm rates of the net models, tests are conducted on different datasets which are SUN2012, LEAR Human and a dataset contains only semi-nudity samples besides validation set determined for each class. The results indicate that high precision rates can be achieved with low false alarm rate exploiting deep net models.
An Analysis of the Defective Response of CBA/N Mice to T-Dependent Antigens (1975)

CBA/N mice fail to respond to T-independent antigens, and give a diminished response to T-dependent antigens. The cellular basis of the diminished response to T-dependent antigens in this strain was analyzed by means of adoptive transfers of various primed cell populations along with cells from the immunologically normal, histocompatible strain CBA/CaJ. CBA/N mice behaved normally as recipients and had normal levels of spleen helper cell activity. However, CBA/N spleen cells, used as a B cell source, produced only 56% as much antibody as CBA/CaJ cells. Since CBA/N mice have a relative frequency of immunoglobulin-bearing lymphocytes roughly half that of normal mice, these results suggest that CBA/N mice have a quantitative defect in spleen B cells responsive to T-dependent antigens.
Crohn’s Disease-Associated Adherent-Invasive Escherichia coli Manipulate Host Autophagy by Impairing SUMOylation (2019)

The intestinal mucosa of Crohn's disease (CD) patients is abnormally colonized with adherent-invasive <i>Escherichia coli</i> (AIEC) that are able to adhere to and to invade intestinal epithelial cells (IECs), to survive in macrophages, and to induce a pro-inflammatory response. AIEC persist in the intestine, and induce inflammation in CEABAC10 transgenic mice expressing human CAECAM6, the receptor for AIEC. SUMOylation is a eukaryotic-reversible post-translational modification, in which SUMO, an ubiquitin-like polypeptide, is covalently linked to target proteins. Here, we investigated the role of SUMOylation in host responses to AIEC infection. We found that infection with the AIEC LF82 reference strain markedly decreased the levels of SUMO-conjugated proteins in human intestinal epithelial T84 cells. This was also observed in IECs from LF82-infected CEABAC10 transgenic mice. LF82-induced deSUMOylation in IECs was due in part to increased level of microRNA (miR)-18, which targets <i>PIAS3</i> mRNA encoding a protein involved in SUMOylation. Over-expression of SUMOs in T84 cells induced autophagy, leading to a significant decrease in the number of intracellular LF82. Consistently, a decreased expression of UBC9, a protein necessary for SUMOylation, was accompanied with a decrease of LF82-induced autophagy, increasing bacterial intracellular proliferation and inflammation. Finally, the inhibition of miR-18 significantly decreased the number of intracellular LF82. In conclusion, our results suggest that AIEC inhibits the autophagy response to replicate intracellularly by manipulating host SUMOylation.
Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations (2021)

The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based cohorts, composing of 1,221 Asians (SEED) and 703 White (WESDR) adults with diabetes. Retinal microvascular signs at baseline included vascular caliber (arteriolar-CRAE, and venular-CRVE) and diabetic retinopathy (DR). Incident cases of DKD were identified after ~ 6-year. Incident cases were defined based on eGFR in SEED and proteinuria or history of renal dialysis in WESDR. The incidence of DKD were 11.8% in SEED and 14.0% in WESDR. Wider CRAE in SEED (OR = 1.58 [1.02, 2.45]) and wider CRVE (OR = 1.69 [1.02, 2.80)) in WESDR were associated with increased risk of DKD. Presence of DR was associated with an increased risk of DKD in both cohorts (SEED: OR = 1.91 [1.21, 3.01] in SEED, WESDR: OR = 1.99 [1.18, 3.35]). Adding DR and retinal vascular calibers in the model beyond traditional risk factors led to an improvement of predictive performance of DKD risk between 1.1 and 2.4%; and improved classification (NRI 3 between 9%). Microvascular changes in the retina are longitudinally associated with risk of DKD.
Poster: Toward Operating System Assisted Hierarchical Memory Management for Heterogeneous Architectures (2012)

The Intel Many Integrated Core (Intel MIC) architecture is Intel's latest design targeted for processing highly parallel workloads. The Intel MIC architecture is implemented on a PCI card, and has its own on-board memory, connected to the host memory through PCI DMA operations. The on-board memory is faster than the one in the host, but it is significantly smaller, requiring the programmer to partition larger computational problems into smaller pieces that can run on a co-processor. However, the Intel MIC architecture features a standard memory management unit (MMU), where the operating system keeps track of the physical memory and manages the mapping from virtual to physical addresses. Thus, the OS running on the many-core unit can transparently move data between the card and the host, similarly how swapping is performed to disk in traditional operating systems. Essentially, the co-processor's memory behaves as another level in the memory hierarchy.
Spin-wave spectra of perpendicularly magnetized circular submicron dot arrays (2004)

Dynamic microwave properties of arrays of circular Ni and Ni81Fe19 dots were studied by X-band ferromagnetic resonance (FMR) technique. All of the dots had the same radius 0.5μm, thickness 50–70nm, and were arranged into rectangular or square array with different interdot separations. In the case of perpendicular magnetization multiple (up to 8) sharp resonance peaks were observed below the main FMR peak, and the relative positions of these peaks were independent of the interdot separations. Quantitative description of the observed multiresonance FMR spectra is given using the dipole-exchange spin wave dispersion equation for a perpendicularly magnetized film where in-plane wave vector is quantized due to the finite dot radius, and the inhomogenetiy of the intradot static demagnetization field in the nonellipsoidal dot is taken into account.
A Pressure Sensitive Two-Dimensional Tetracyanoquinodimethane (TCNQ) Salt of a Stable Free Radical (1996)

International audience
A back-to-back MOS–Schottky (Pt–SiO2–Si–C–Pt) nano-heterojunction device as an efficient self-powered photodetector: one step fabrication by pulsed laser deposition (2014)

An efficient self-powered photodetector design involving a C-Si hetero-interface with back-to-back MOS-Schottky (Pt-SiO2-Si-C-Pt) device action is presented. Pulsed laser deposition of a carbon thin film is used which dynamically removes the native surface oxide to form the desired Schottky interface. The combined device action yields two orders of magnitude photoresponse at zero bias.
Solvent extraction of penicillin (1946)

Abstract The extraction method for the purification and concentration of penicillin is reviewed. The theoretical basis underlying the extraction process is examined. A simple distribution formula reproduces the results well and in used to examine the dependence of the selectivity of a solvent on pH of extraction. A number of solvents were tested, most of them show better solvent power for penicillin than the widely‐used amyl acetate. Outstanding amongst these solvents are the cyclic ketones such as methylcyclo‐hexanone and dimethylcyclohexanone.* With these solvents efficient extraction at pH4 is possible, thus avoiding contact of penicillin with solutions of greater acidity where it becomes unstable. The selectivity of these solvents is examined and found to increase with the pH of extraction. At pH4 the selectivity of methylcyclobexanone approached that of chloroform, the latter being a very selective solvent for penicillin.
Net Zero Urban Water from Concept to Applications: Integrating Natural, Built, and Social Systems for Responsive and Adaptive Solutions (2020)

Innovation in urban water systems is required to address drivers of change across natural, built, and social systems, including climate change, economic development, and aged infrastructure. Water systems are complex socio-technical systems that interact with biophysical systems to supply and reclaim water. We present a vision for enhancing urban water system resilience through a net zero urban water (NZUW) approach, which meets the needs of a given community with a locally available and sustainable water supply, without detriment to interconnected systems or long-term water supply. NZUW is an integrative approach with progressive targets assessed using a quantitative framework to expand adaptive and responsive solutions for urban water self-sufficiency. Decision makers can use NZUW to understand trade-offs between future interventions to urban water systems across spatial and temporal scales. We present the overall NZUW approach, drivers of change, applications, and research gaps.
Carbon Fiber Biocompatibility for Implants (2016)

Carbon fibers have multiple potential advantages in developing high-strength biomaterials with a density close to bone for better stress transfer and electrical properties that enhance tissue formation. As a breakthrough example in biomaterials, a 1.5 mm diameter bisphenol-epoxy/carbon-fiber-reinforced composite rod was compared for two weeks in a rat tibia model with a similar 1.5 mm diameter titanium-6-4 alloy screw manufactured to retain bone implants. Results showed that carbon-fiber-reinforced composite stimulated osseointegration inside the tibia bone marrow measured as percent bone area (PBA) to a great extent when compared to the titanium-6-4 alloy at statistically significant levels. PBA increased significantly with the carbon-fiber composite over the titanium-6-4 alloy for distances from the implant surfaces of 0.1 mm at 77.7% vs. 19.3% (<i>p</i> < 10<sup>-8</sup>) and 0.8 mm at 41.6% <i>vs</i>. 19.5% (<i>p</i> < 10<sup>-4</sup>), respectively. The review focuses on carbon fiber properties that increased PBA for enhanced implant osseointegration. Carbon fibers acting as polymer coated electrically conducting micro-biocircuits appear to provide a biocompatible semi-antioxidant property to remove damaging electron free radicals from the surrounding implant surface. Further, carbon fibers by removing excess electrons produced from the cellular mitochondrial electron transport chain during periods of hypoxia perhaps stimulate bone cell recruitment by free-radical chemotactic influences. In addition, well-studied bioorganic cell actin carbon fiber growth would appear to interface in close contact with the carbon-fiber-reinforced composite implant. Resulting subsequent actin carbon fiber/implant carbon fiber contacts then could help in discharging the electron biological overloads through electrochemical gradients to lower negative charges and lower concentration.
Identification of Annual Water Demand Patterns in the City of Naples (2018)

In the present paper, different clustering techniques were applied to detect significant patterns describing single-household water consumption in a residential neighborhood of the City of Naples, basing on hourly time series aggregated at the monthly scale. Comparisons among results were performed by means of a selection of Clustering Validity Indices, that were adjusted to overcome a bias caused by sparsely populated clusters. The most performant cluster solution proved to be the one resulting from the application of a mixed strategy, namely a Self-Organized Map followed by K-means performed on first level cluster centroids.
A microarray‐based approach for the identification of epigenetic biomarkers for the noninvasive diagnosis of fetal disease (2009)

This high-resolution analysis of DNA methylation patterns in the human placenta during the first trimester of pregnancy identifies numerous potential biomarkers for the diagnosis of fetal aneuploidy on chromosomes 13, 18 and 21.
Finding curves in SAR CCD images (2011)

This paper introduces a pattern recognition and computer vision approach to mitigating false alarms in synthetic aperture radar (SAR) coherence change detection (CCD) images. In this paper, we perform an automatic detection of roads in SAR CCD images. The approach is based on a curve tracing algorithm originally proposed by Steger with modifications to better suit the goal of curve detection in SAR CCD images. In our technique, the traditional Steger's method is used to detect curve points, and cubic splines are used to approximate the original curve. To detect roads more accurately, preprocessing and outlier removal techniques are performed along with the curve detection.
STATE OF STATISTICAL DATA EDITING AND CURRENT RESEARCH PROBLEMS (1999)

This paper is my description of the state of statistical data editing and current research problems. It is not intended to be a complete description of all areas. Rather, it represents sub-areas of statistical data editing that I will describe in sufficient detail so that the discussion of a few research problems is more easily understood.
Einfluss der Tabakmonokultur und der Fruchtfolge auf die Beschaffenheit des Tabakblattes (2004)

From the wider context of broadly conceived long-term experiments with growing tobacco in monoculture and different crop rotations, this paper presents results on the achieved yields and major yield components for crops grown, as well as participation of particular tobacco classes. In addition to tobacco monoculture, at first only fertilized and later on also unfertilized, as the key crop, different types of crop rotations included, besides tobacco, the following crops: winter wheat, maize, soybean, oil-seed rape, and red clover. Experiments involved two 2-year and two 4-year crop rotations, and a 3-year, a 5-year, and a 6-year crop rotation each. Experiments were set up on luvic semigley on multi-layered Pleistocene sands. Average 10-year results point to the advantage of crop rotation over monoculture for tobacco leaf yields. Influence of different crop rotation types upon yields of other crops was variable, tending towards higher values with increasing the number of crops in rotation. Values obtained for yield components should be considered from two aspects. Namely, some of them were primarily genetically conditioned while the others were influenced by ecological factors, including crop rotation as an overall biological buffer. With regard to participation of quality classes (I-III), growing of flue-cured tobacco in crop rotation represents a great advancement relative to its growing in monoculture, even in a narrower crop rotation.