gebhart/patrepeval huggingface dataset:
Epithelial Splicing Regulatory Protein 1 is a Favorable Prognostic Factor in Pancreatic Cancer that Attenuates Pancreatic Metastases (2014)

Epithelial splicing regulatory protein 1 (ESRP1) binds the FGFR-2 auxiliary cis-element ISE/ISS-3, located in the intron between exon IIIb and IIIc, and primarily promotes FGFR-2 IIIb expression. Here we assessed the role of ESRP1 in pancreatic ductal adenocarcinoma (PDAC). Immunohistochemical analysis was performed using anti-ESRP1, FGFR-2 IIIb and FGFR-2 IIIc antibodies in 123 PDAC cases. ESRP1 expression vector and small interference RNA (siRNA) targeting ESRP1 were transfected into human PDAC cells, and cell growth, migration and invasion were analyzed. In vivo heterotopic and orthotopic implantations using ESRP1 overexpression clones were performed and effects on pancreatic tumor volumes and hepatic and pulmonary metastases determined. ESRP1 immunoreactivity was strong in the nuclei of cancer cells in well-to-moderately differentiated PDACs but weak in poorly differentiated cancers. Well-to-moderately differentiated cancers also exhibited high FGFR-2 IIIb and low FGFR-2 IIIc expression, whereas this ratio was reversed in the poorly differentiated cancers. Increased ESRP1 expression was associated with longer survival in comparison with low ESRP1 expression, and PANC-1 cells engineered to express ESRP1 exhibited increased FGFR-2 IIIb expression and decreased migration and invasion in vitro, whereas ESRP1 siRNA-transfected KLM-1 cells exhibited increased FGFR-2 IIIc expression and increased cell growth, migration and invasion. In vivo, ESRP1-overexpressing clones formed significantly fewer liver metastases as compared with control clones. ESRP1 regulates the expression pattern of FGFR-2 isoforms, attenuates cell growth, migration, invasion and metastasis, and is a favorable prognostic factor in PDAC. Therefore, devising mechanisms to upregulate ESRP1 may exert a beneficial therapeutic effect in PDAC.
Battery Life-Cycle Optimization and Runtime Control for Commercial Buildings Demand Side Management: A New York City Case Study (2018)

In metropolitan areas populated with commercial buildings, electric power supply is stringent especially during business hours. Demand side management using battery is a promising solution to mitigate peak demands, however long payback time creates barriers for large scale adoption. In this paper, we have developed a design phase battery life-cycle cost assessment tool and a runtime controller for the building owners, taking into account the degradation of battery. In the design phase, perfect knowledge on building load profile is assumed to estimate ideal payback time. In runtime, stochastic programming and load predictions are applied to address the uncertainties in loads for producing optimal battery operation. For validation, we have performed numerical experiments using the real-life tariff model serves New York City, Zn/MnO2 battery, and state-of-the-art building simulation tool. Experimental results shows a small gap between design phase assessment and runtime control. To further examine the proposed methods, we have applied the same tariff model and performed numerical experiments on nine weather zones and three types of commercial buildings. On contrary to the common practice of shallow discharging battery for preventing phenomenal degradation, experimental results show promising payback time achieved by optimally deep discharge a battery.
RSR13, a synthetic allosteric modifier of hemoglobin, as an adjunct to radiotherapy:Preliminary studies with EMT6 cells and tumors and normal tissues in mice (1998)

RSR13, 2[4-[[(3,5dimethylanilino)carbonyl]methyl]phenoxy]-2-methylpropion ic acid, a synthetic allosteric modifier of hemoglobin, reduces the affinity of hemoglobin for oxygen. The experiments reported here examined the effect of treatment with RSR13, combined with oxygen breathing, on the radiation response of EMT6 mammary tumors in BALB/c mice and of two normal tissues. RSR13 plus oxygen breathing increased the response of EMT6 tumors to irradiation. RSR13 had no discernible effects on tumors rendered maximally hypoxic by nitrogen asphyxiation, no discernible cytotoxic effects in EMT6 tumors, and no effect on the viability or radiation response of EMT6 cells in vitro under either aerobic or hypoxic conditions. The effects of RSR13 therefore reflect changes in tumor oxygenation, rather than a direct cytotoxic or radiosensitizing effect of the drug. RSR13 plus oxygen reduced the hypoxic fraction to 9% from the value of 24% found in both air-breathing and oxygen-breathing mice. Treatment with RSR13 plus oxygen did not alter the radiation response of the bone marrow progenitor cells (CFU-S) or acute radiation reactions in the skin. The improvement in tumor radiation response produced by treatment with RSR13 plus oxygen, combined with the absence of enhanced radiation reactions in the normal tissues, support further testing of RSR13 as an adjunct to radiotherapy.
AtCAT6, a sink‐tissue‐localized transporter for essential amino acids in Arabidopsis (2006)

Summary Amino acids represent the major form of reduced nitrogen that is transported in plants. Amino acid transporters in plants often show tissue‐specific expression patterns and are used by plants to transport these metabolites from source to sink during development and under changing environmental conditions. We identified one amino acid transporter, AtCAT6, which is expressed in sink tissues such as lateral root primordia, flowers and seeds. Additionally AtCAT6 was induced during infestation of roots by the plant‐parasitic root‐knot nematode, Meloidogyne incognita . Quantitative reverse‐transcriptase PCR revealed nematode inducibility throughout the duration of nematode infestation and in nematode‐induced feeding sites. Promoter analyses confirmed expression in endogenous sink tissues and nematode‐induced feeding sites. In Xenopus oocytes, AtCAT6 mediated electrogenic transport of proteinogenic as well as non‐proteinogenic amino acids with moderate affinity. AtCAT6 transported large, neutral and cationic amino acids in preference to other amino acids. Knockout mutants of this transporter failed to grow on medium containing l ‐glutamine as the sole nitrogen source. Our data suggest that AtCAT6 plays a role in supplying amino acids to sink tissues of plants and nematode‐induced feeding structures.
Surgical Therapy of Acute Esophageal Variceal Hemorrhage (1992)

Options for the management of patients with acute variceal hemorrhage must be compared for their ability to stop bleeding and prevent rebleeding, for their safety, and for their impact on hepatic reserve. Pharmacologic treatment may stop bleeding in up to 50% of patients, but cannot prevent rebleeding. Balloon tamponade controls bleeding in 90% of patients but is only transiently effective and may cause complications. Immediate sclerotherapy may stop acute bleeding and may provide chronic control with repeated treatments. However, patients who fail to respond to such measures must be submitted for surgical intervention. Emergency portosystemic shunt or esophageal transection represent the current procedures of choice for these patients. Surgery may also prove more cost effective than repeated sclerotherapy as primary therapy in a select group of patients with a high risk of rebleeding. Ultimately, however, primary pharmacologic therapy or hepatic transplantation to correct the pathophysiology underlying the esophageal variceal hemorrhage must be developed and refined if the natural history of this disease is to be substantially altered.
Development of wireless communication demonstration unit on intra-satellite (2023)

We have developed a wireless communication demonstration unit called WICS for the engineering test satellite-9 (ETS-9), a Japanese engineering test satellite. After confirming the environmental resistance performance using the engineering model (EM), the proto-flight model (PFM) manufacturing and the environmental test of vibration, thermal vacuum, and electromagnetic compatibility tests were completed without any problems. Compatibility testing with satellite systems is planned for this year, with in-orbit demonstrations planned for 2023 and beyond. Based on the on-orbit demonstration results, we will consider the upper layer design and expand the scope of the application of wireless technology applications in the future.
Regional Specificity of Gamma-Aminobutyric Acid Receptor Regulation by Estradiol (1988)

In vitro quantitative autoradiography and the microdissection technique of Palkovitz were used to examine the effects of estradiol-17 beta on GABAA receptors and on glutamic acid decarboxylase in discrete areas of rat brain. Under the conditions examined, estradiol did not affect glutamic acid decarboxylase activity. However, treatment with estradiol decreased GABAA receptor binding in a majority of areas that contain high levels of intracellular estradiol receptors and in a number of areas that contain few or no estradiol receptors. Within one brain area, the ventromedial nucleus of the hypothalamus, the estradiol effect was mapped and found to occur within the estradiol-sensitive ventrolateral portion and the surrounding dendritic plexus. Time- and dose-response relationships were region specific suggesting that estradiol might influence GABAA-receptor binding through multiple mechanisms. Estradiol does not appear to interact directly with GABAA receptors since addition of estradiol to the assay system did not affect binding. Our findings suggest that one way estradiol might affect neuroendocrine and other centrally mediated processes is through effects on GABAA-receptor binding.
Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases. (1985)

The etiology of keratoconjunctivitis sicca (KCS) in 62 dogs was evaluated, using immunologic techniques. Using direct fluorescent antibody testing, autoantibodies within the lacrimal, salivary, or pancreatic glands were detected in 5 of 8 dogs tested. Circulating antibodies to the nictitating membrane gland, main lacrimal gland, parotid salivary gland, or mandibular salivary gland were detected using indirect fluorescent antibodies in 9 of 31, 3 of 31, 5 of 31, and 5 of 31 sera, respectively. Using radial immunodiffusion, hyper-gamma-globulinemia was detected in 21 of 30 dogs with KCS. Antinuclear antibodies, primarily in a nucleolar pattern, were demonstrated in 20 of 50 dogs with KCS. Lymphocytic infiltrates were evident in 5 of 9 labial salivary biopsies, 2 of 4 parotid gland specimens, 2 of 4 mandibular gland specimens, and 2 of 3 thyroid gland specimens taken from dogs with KCS. Autoimmune diseases had been previously documented in 4 of 62 dogs. Twenty-five of the 62 dogs (40%) had concurrent problems indicative of an underlying immunologic disorder.
Aseptic technology of vitrification of human pronuclear oocytes using open-pulled straws (2004)

The deposition of human pronuclear oocytes in open-pulled straws which are placed inside a hermetically closed container guarantees a complete isolation of oocytes from liquid nitrogen and avoids potential contamination by pathogenic microorganisms. The combination of direct plunging of this container into liquid nitrogen and rapid warming makes this process as efficient as conventional vitrification.
Supplemental figure 4 from Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma (2023)

&lt;p&gt;Supplemental figure 4. IL6 and IL10 levels. Shown are data from five patients with elevated IL12 and IFNg levels that were subject to cytokine multiplex analysis. Only cytokine IL6 and IL10 were shown to be consistently elevated post-infusion.&lt;/p&gt;
Determining the Anchoring Strength of a Capillary Using Topological Defects (1996)

We consider a smectic-A* in a capillary with surface anchoring that favors parallel alignment. If the bulk phase of the smectic is the standard twist-grain-boundary phase of chiral smectics, then there will be a critical radius below which the smectic will not have any topological defects. Above this radius a single screw dislocation in the center of the capillary will be favored. Along with surface anchoring, a magnetic field will also suppress the formation of a screw dislocation. In this note, we calculate the critical field at which a defect is energetically preferred as a function of the surface anchoring strength and the capillary radius. Experiments at a few different radii could thus determine the anchoring strength.
Acque e paesaggi d'invenzione. Descrizione, meraviglia e nuova interpretazione di infrastrutture e architetture dell'acqua. (2020)

Il volume propone una riflessione la cui chiave di volta è costituita da una esperienza diretta di immersione, studio e interpretazione critica di un paesaggio generato da una infrastruttura idraulica storica, di valore conclamato, come il Naviglio Grande milanese. Si esplorano le modalità per descrivere la complessità e il grado di umanizzazione di un paesaggio squisitamente 'inventato', approfondendo il nesso che lega una materia sfuggevole come l'acqua, al carattere dell'infrastruttura da cui dipende la sua forma. Ciò conduce alla scoperta di un vasto campo di 'possibilità' che la sostanza liquida può rappresentare come componente in grado di stabilire relazioni, caratterizzare i luoghi, suscitare emozioni e dar senso a 'nuovi paesaggi'. Un libro, riccamente illustrato da mappe, sezioni e fotografie, dimostrativo delle modalità di costruzione e di impiego critico di queste forme della rappresentazione. Un testo che si indirizza a una pluralità di lettori: da chi si occupa di paesaggio, a chi è deputato alla sua gestione, alla comunità accademica e agli studenti di architettura, a cui viene offerta un'occasione di riflessione originale sul tema del paesaggio.
Software update via mobile agent based programming (2002)

We describe a system that permits maintaining the software installed on several heterogeneous computers distributed over a network by taking advantage of the mobile agent paradigm. The applications are installed and updated only on the central server. When a new release of an application is installed on the server, agents are scattered along the network to update the application on the clients.To build a prototype system we use X-KLAIM, a programming language specifically designed to program distributed systems composed of several components interacting through multiple tuple spaces and mobile code.
Fabrication of Silicon Nanowire Metal-Oxide-Semiconductor Capacitors with Al2O3/TiO2/Al2O3 Stacked Dielectric Films for the Application to Energy Storage Devices (2021)

Silicon nanowire (SiNW) metal-oxide-semiconductor (MOS) capacitors with Al2O3/TiO2/Al2O3 (ATA) stacked dielectric films were fabricated by metal-assisted chemical etching (MACE) and atomic layer deposition (ALD). High-angle annular dark field scanning transmission electron microscopy (HAADF-STEM) images revealed that SiNWs were conformally coated with ATA although the cross-sectional shapes of MACE-SiNWs were non-uniform and sharp spikes can be seen locally. The dielectric capacitance density of 5.9 μF/cm2 at V = −4 V of the perfect accumulation region was achieved due to the combination of the large surface area of the SiNW array and the high dielectric constant of ATA. The capacitance changed exponentially with the voltage at V &lt; −4.3 V and the capacitance of 84 μF/cm2 was successfully achieved at V = −10 V. It was revealed that not only 3D structure and high-k material but also local nanostructure of SiNWs and stacked dielectric layers could contribute to the considerable high capacitance.
Impurities in diamond- a new revival for quantum optics (2010)

Realization of novel quantum technologies requires a control over their fundamental constituent- a single photon emitter. In this work we will present a comparative study of single photon emitters based on color centers in diamond which deliver performance comparable with decoy state implementation with weak coherent sources, and are most suitable for practical applications. In particular we will present the photo-physical properties of a novel family of single photon emitters, originated from Cr impurities in the diamond lattice, which exhibit a typical emission lines in the range of 740-760 nm, and a count rate in the range of 0.8-3.2 106 counts/s. We will highlight future directions to optimize these sources and present simulations of their performance in practical devices.
RKIP Structure Drives Its Function: A Three-State Model for Regulation of RKIP (2014)

Raf kinase inhibitory protein (RKIP) is a highly conserved regulator of many signaling networks whose loss or inactivation can lead to a variety of disease states. The multifaceted roles played by RKIP are enabled by an allosteric structure that is controlled through phosphorylation of RKIP and dynamics in the RKIP pocket loop. Perhaps the most striking feature of RKIP is that it can assume multiple functional states. Specifically, phosphorylation redirects RKIP from a state that binds and inhibits Raf-1 to a state that binds and inhibits GRK2. Recent evidence suggests the presence of a third functional state that facilitates RKIP phosphorylation. Here, we present a three-state model to explain the RKIP functional switch and discuss the role of the pocket loop in regulating RKIP activity.
Why Cats Land on Their Feet and 76 Other Physical Paradoxes and Puzzles. (2012)

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Phase Detection Based Surface Plasmon Resonance Biosensor in Infrared with Increased Sensitivity and Dynamic Range (2007)

A novel method of phase-detection in the infrared is proposed to enhance the sensitivity and dynamic range of a single-wavelength surface plasmon resonance biosensor. A structure is also proposed to prevent the sensitivity degradation.
Uracil/tegafur plus oral calcium folinate in advanced breast cancer. (1999)

Uracil and tegafur (in a molar ratio of 4:1 [UFT]) has proven activity against breast cancer and is delivered in an easy-to-administer oral formulation. Orzel, which combines UFT with the oral biomodulator, calcium folinate, may provide even greater antitumor efficacy against breast cancer. Here, we describe the preliminary results of this phase II trial investigating the feasibility of 250 mg/m2/day of UFT plus 45 mg/day of oral calcium folinate administered to highly pretreated patients with advanced breast cancer. The results indicate a highly tolerable regimen and an overall response rate of 27.8% in a group of poor-prognosis patients. These findings warrant continued investigation.
Are inositol pyrophosphates signalling molecules? (2009)

The inositol polyphosphate family of small, cytosolic molecules has a prominent place in the field of cell signalling, and inositol pyrophosphates are the most recent addition to this large family. First identified in 1993, they have since been found in all eukaryotic organisms studied. The defining feature of inositol pyrophosphates is the presence of the characteristic 'high energy' pyrophosphate group, which immediately attracted interest in them as possible signalling molecules. In addition to their unique 'high energy' pyrophosphate bond, their concentration in the cell is tightly regulated with an extremely rapid turnover. This, together with the history of other inositol polyphosphates, makes it likely that they have an important role in intracellular signalling involving some basic cellular processes. This hypothesis is supported by the surprisingly wide range of cellular functions where inositol pyrophosphates seem to be involved. A seminal finding was that inositol pyrophosphates are able to directly phosphorylate pre-phosphorylated proteins, thereby identifying an entirely new post-translational protein modification, namely serine-pyrophosphorylation. Rapid progress has been made in characterising the metabolism of these molecules in the 15 years since their first identification. However, their detailed signalling role in specific cellular processes and in the context of relevant physiological cues has developed more slowly, particularly in mammalian system. We will discuss inositol pyrophosphates from the cell signalling perspective, analysing how their intracellular concentration is modulated, what their possible molecular mechanisms of action are, together with the physiological consequences of this novel form of signalling.
Affinity Capturing and Surface Enrichment of a Membrane Protein Embedded in a Continuous Supported Lipid Bilayer (2016)

Investigations of ligand-binding kinetics to membrane proteins are hampered by their poor stability and low expression levels, which often translates into sensitivity-related limitations impaired by low signal-to-noise ratios. Inspired by affinity capturing of water-soluble proteins, which utilizes water as the mobile phase, we demonstrate affinity capturing and local enrichment of membrane proteins by using a fluid lipid bilayer as the mobile phase. Specific membrane-protein capturing and enrichment in a microfluidic channel was accomplished by immobilizing a synthesized trivalent nitrilotriacetic acid (tris-NTA)-biotin conjugate. A polymer-supported lipid bilayer containing His<sub>6</sub>-tagged β-secretase (BACE) was subsequently laterally moved over the capture region by using a hydrodynamic flow. Specific enrichment of His<sub>6</sub>-BACE in the Ni<sup>2+</sup>-NTA-modified region of the substrate resulted in a stationary three-fold increase in surface coverage, and an accompanied increase in ligand-binding response.
Supplementary Table Legend from MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer (2023)

&lt;p&gt;Supplementary Table Legend for Xie et al, MEK inhibition modulates cytokine response to mediate therapeutic efficacy in lung cancer&lt;/p&gt;
Heterocyclic imines and amines. Part 18. Conversion of o-cyanobenzyl cyanide into isoquinoline, benzylisoquinoline, and azachrysene products (1983)

With sodamide in formamide, o-cyanobenzyl cyanide dimerises in the two ways possible: it also adds formamide to yield 1-amino-3-formamidoisoquinoline (2). Each dimer undergoes cycloisomerisation: thus 1-amino-3-o-cyanobenzyl-4-cyanoisoquinoline (5a) and 6,11-diamino-12-cyanobenzo[c]phenanthridine (9) were isolated. o-Cyanobenzyl cyanide with sodium methoxide afforded (5a) very slowly in methanol but much more rapidly in dimethyl sulphoxide–methanol.
Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort: discrepancies with local readers and impact on the performance of the ASAS criteria (2020)

Despite substantial discrepancy between central and local readers in interpretation of both types of MRI lesion, this had a minor impact on the numbers of patients classified as axSpA supporting the robustness of the ASAS criteria for differences in assessment of imaging.
Wetting of Octadecylsilylated Silica in Methanol−Water Eluents (1996)

The wetting of an octadecylsilylated silica in methanol-water mixtures was studied by optical transmittance, visual observations, and measurements of the retention of model compounds. The octadecylsilylated silica particles remain wetted as the methanol content is decreased from 100% (v/v) to 20% (v/v). With the methanol content in the range of 20% (v/v) to 10% (v/v), the octadecylsilylated silica particles are still wetted, but the degree of solvation of the C(18) chains decreases with decreasing methanol concentration. The octadecylsilylated silica particles are not wetted when the methanol content in the mobile phase is lower than 10% (v/v). After equilibration with water, the octadecylsilylated silica particles remain nonwetted until the methanol content reaches 65% (v/v). The nonwetted phase showed significantly reduced chromatographic retention. A much longer equilibration time is required when the octadecylsilylated silica particles are not well solvated or nonwetted. The retentive behavior of the column will depend on the history of mobile-phase exposure.