gebhart/patrepeval huggingface dataset:
Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism (2006)

Kv1.3 is a voltage-gated K(+) channel expressed in insulin-sensitive tissues. We previously showed that gene inactivation or pharmacological inhibition of Kv1.3 channel activity increased peripheral insulin sensitivity independently of body weight by augmenting the amount of GLUT4 at the plasma membrane. In the present study, we further examined the effect Kv1.3 on GLUT4 trafficking and tested whether it occurred via an insulin-dependent pathway. We found that Kv1.3 inhibition by margatoxin (MgTX) stimulated glucose uptake in adipose tissue and skeletal muscle and that the effect of MgTX on glucose transport was additive to that of insulin. Furthermore, whereas the increase in uptake was wortmannin insensitive, it was completely inhibited by dantrolene, a blocker of Ca(2+) release from intracellular Ca(2+) stores. In white adipocytes in primary culture, channel inhibition by Psora-4 increased GLUT4 translocation to the plasma membrane. In these cells, GLUT4 protein translocation was unaffected by the addition of wortmannin but was significantly inhibited by dantrolene. Channel inhibition depolarized the membrane voltage and led to sustained, dantrolene-sensitive oscillations in intracellular Ca(2+) concentration. These results indicate that the apparent increase in insulin sensitivity observed in association with inhibition of Kv1.3 channel activity is mediated by an increase in GLUT4 protein at the plasma membrane, which occurs largely through a Ca(2+)-dependent process.
Environmental inversion and matched-field tracking with a surface ship and an L-shaped receiver array (2004)

Acoustic data from the natural broadband signature of a quiet surface ship, recorded on the vertical leg of an L-shaped array, is used to invert for the local geo-acoustic parameters and the resulting effective environment is used for subsequent tracking of the surface ship using a matched-field tracking technique applied to the full array. The matched-field analysis includes a comparison of the incoherent product of the processed data from the horizontal and vertical subapertures with coherent processing of the data from the full L-shaped array. Subaperture processing is of interest since there is a (loose) requirement that the number of data snapshots be greater than or equal to the number of array elements. This presents averaging difficulties for large arrays when the source being observed is moving. Analyzing each array leg separately allows the use of a smaller number of snapshots from which averaged quantities are constructed. Taken separately, the vertical leg of the array provides range-depth information, while the horizontal leg provides bearing information. The incoherent product of each leg is compared to processing the full array coherently illustrating that the incoherent product generally worked as well, or better than, processing the full array, producing compact maxima at the ship location, and producing fewer false source locations.
CoP nanoparticles deposited on reduced graphene oxide sheets as an active electrocatalyst for the hydrogen evolution reaction (2015)

A novel CoP/RGO composite with excellent electrocatalytic activity towards HER was prepared using a facile two-step strategy.
Imaging for Nephrolithiasis (2017)

Nephrolithiasis is a common condition that affects a large number of Americans. An imaging diagnosis is required for adequate treatment and follow-up, and a large variety of imaging modalities exist for this purpose. In this review, we discuss the advantages, disadvantages, and specific uses for a wide array of imaging methods, including plain radiography, ultrasonography, CT, and others. In addition, special attention is paid to specific clinical situations for individual tests, such as when dealing with children, pregnant women, and patients in an intraoperative setting. Approximate costs and radiation doses of each modality are discussed as well. At the conclusion of this review, the reader should understand the utility of each imaging technique, along with the optimal situation for use and reasoning for these decisions. This review contains 5 highly rendered figures, 2 tables, and 85 references Key words: CT, diagnosis, digital tomosynthesis, fluoroscopy, follow-up, imaging, intravenous pyelography, MRI, nephrolithiasis, radiation dose, radiography, ultrasonography
Influence of Magnetic Fields on Electrochemical Reactions of Redox Cofactor Solutions (2021)

Abstract Redox cofactors mediate many enzymatic processes and are increasingly employed in biomedical and energy applications. Exploring the influence of external magnetic fields on redox cofactor chemistry can enhance our understanding of magnetic‐field‐sensitive biological processes and allow the application of magnetic fields to modulate redox reactions involving cofactors. Through a combination of experiments and modeling, we investigate the influence of magnetic fields on electrochemical reactions in redox cofactor solutions. By employing flavin mononucleotide (FMN) cofactor as a model system, we characterize magnetically induced changes in Faradaic currents. We find that radical pair intermediates have negligible influence on current increases in FMN solution upon application of a magnetic field. The dominant mechanism underlying the observed current increases is the magneto‐hydrodynamic effect. We extend our analyses to other diffusion‐limited electrochemical reactions of redox cofactor solutions and arrive at similar conclusions, highlighting the opportunity to use this framework in redox cofactor chemistry.
Optional wh-movement is discourse-connected movement in Eastern Cham (2019)

Eastern Cham (Austronesian: Vietnam) exhibits apparent optional wh-movement, which shares properties with apparent topicalization. This paper demonstrates that it is not true wh-movement, but discourse connected-, or DC-movement. DC requires a phrase to have an antecedent in a prior sentence and for the antecedent's sentence and the anaphor's sentence to be in a particular discourse structural configuration. Data from complex DP's, specifically partitives, inventory forms, and close appositives demonstrate that DC is a property of referential indices that bind DP's. The incompatibility of wh-phrases and topicality is then explained as the inability of wh-phrases to supply referential indices on their own.
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors (2009)

The CDC73 tumor suppressor gene is mutationally inactivated in hereditary and sporadic parathyroid tumors. Its product, the Cdc73 protein, is a component of the RNA polymerase II and chromatin-associated human Paf1 complex (Paf1C). Here, we show that Cdc73 physically associates with the cleavage and polyadenylation specificity factor (CPSF) and cleavage stimulation factor (CstF) complexes that are required for the maturation of mRNA 3' ends in the cell nucleus. Immunodepletion experiments indicate that the Cdc73-CPSF-CstF complex is necessary for 3' mRNA processing in vitro. Microarray analysis of CDC73 siRNA-treated cells revealed INTS6, a gene encoding a subunit of the Integrator complex, as an in vivo Cdc73 target. Cdc73 depletion by siRNA resulted in decreased INTS6 mRNA abundance, and decreased association of CPSF and CstF subunits with the INTS6 locus. Our results suggest that Cdc73 facilitates association of 3' mRNA processing factors with actively-transcribed chromatin and support the importance of links between tumor suppression and mRNA maturation.
In Vitro Recoating of Reovirus Cores with Baculovirus-Expressed Outer-Capsid Proteins μ1 and ς3 (1999)

ABSTRACT Reovirus outer-capsid proteins μ1, ς3, and ς1 are thought to be assembled onto nascent core-like particles within infected cells, leading to the production of progeny virions. Consistent with this model, we report the in vitro assembly of baculovirus-expressed μ1 and ς3 onto purified cores that lack μ1, ς3, and ς1. The resulting particles (recoated cores, or r-cores) closely resembled native virions in protein composition (except for lacking cell attachment protein ς1), buoyant density, and particle morphology by scanning cryoelectron microscopy. Transmission cryoelectron microscopy and image reconstruction of r-cores confirmed that they closely resembled virions in the structure of the outer capsid and revealed that assembly of μ1 and ς3 onto cores had induced rearrangement of the pentameric λ2 turrets into a conformation approximating that in virions. r-cores, like virions, underwent proteolytic conversion to particles resembling native ISVPs (infectious subvirion particles) in protein composition, particle morphology, and capacity to permeabilize membranes in vitro. r-cores were 250- to 500-fold more infectious than cores in murine L cells and, like virions but not ISVPs or cores, were inhibited from productively infecting these cells by the presence of either NH 4 Cl or E-64. The latter results suggest that r-cores and virions used similar routes of entry into L cells, including processing by lysosomal cysteine proteinases, even though the former particles lacked the ς1 protein. To examine the utility of r-cores for genetic dissections of μ1 functions in reovirus entry, we generated r-cores containing a mutant form of μ1 that had been engineered to resist cleavage at the δ:φ junction during conversion to ISVP-like particles by chymotrypsin in vitro. Despite their deficit in δ:φ cleavage, these ISVP-like particles were fully competent to permeabilize membranes in vitro and to infect L cells in the presence of NH 4 Cl, providing new evidence that this cleavage is dispensable for productive infection.
A novel inkjet printed carbon nanotube-based chipless RFID sensor for gas detection (2013)

International audience
Interoperable IPv6 Sensor Networking over PLC and RF Media (2010)

The evolution of technology has made the connection of all types of devices to IP networks possible. In this paper, the authors investigate the possible usage of IPv6 in sensor networks connected through the Power Line Communication (PLC) non-wireless medium and demonstrate possible interoperability. This work is based on the adaptation of the IEEE 802.15.4 standard protocol constrained by the low-power, lossy and low data-rate context of PLC transceiver that uses pulse modulation. The aim is to provide interoperability features with other media using a robust and reliable communication stack. The target application of such results ranges from smart metering and environment monitoring to home control and urban area energy efficiency applications. This paper proposes the first adaptation of the IEEE 802.15.4 standard commons for the PLC medium. Following this standard interface, the authors demonstrate data communication on PLC with low power energy requirement using the pulse PLC physical layer. This paper also presents an initial implementation of the Routing Protocol for Low power and lossy networks (RPL) setup proposed by the IETF working group. In this context, the authors demonstrate interoperability in a testbed between PLC and Wireless Sensor Networks (WSN).
Automatic Transpiler that Efficiently Converts Digital Circuits to a Neural Network Representation (2022)

Digital circuits are the basic structure of most of today's electronic devices. Simulation plays a critical role in the iterative development of such circuits as a consequence of the time and financial expenses that accompany fabrication. There are existing tools that achieve simulation by modeling circuits with Hardware Description Languages (HDL). However, with recent advances in neural networks (NN) and hardware accelerators for NN simulation, a niche of digital circuit simulation via NNs has opened up. Here, we introduce C2NN (Circuit to Neural Network), a novel method that converts (or transpiles) any digital circuit expressed in a HDL into a NN for simulation. The conversion to a NN representation not only affords the benefits of parallelization, the use of GPUs for simulation, and optimizations such as pruning, but it also provides a methodology for achieving equivalent digital circuit computation in neuromorphic hardware. We describe the transpilation process of C2NN and verify its correctness on small- and large-scale digital circuits. We also found that the simulation time of the transpiled circuits is competitive with one of the fastest digital circuit simulators.
Multiple-mirror trap: a path from Budker magnetic mirrors to linear fusion reactor (2018)

This review is focused on multiple-mirror traps for high-temperature plasma confinement that were proposed by Budker, Mirnov, and Ryutov and independently by Logan, Lichtenberg, and Lieberman in the early 1970s. The proposed magnetic system solved problems with the kinetic instabilities of classical open traps and significantly increased the plasma life-time. We review the history of this field and discuss its achievements and prospects.
A Tryptophan Pyrolysis Product, 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) but Not Its Metabolite Induces Apoptosis in Primary Cultured Rat Hepatocytes (2003)

Heterocyclic amines, which are formed during the daily cooking process, are the typical carcinogen and considered to be one of the major causes of human cancer. Their carcinogenic or mutagenic activity has been well studied, but the cytotoxicity to normal cells is little known. Previously, we demonstrated that Trp-P-1 also induces apoptosis to primary cultured rat hepatocytes. However, it is not clear which form, intact Trp-P-1 or its metabolite, induces apoptosis. In the carcinogenic process, the N-hydroxylation of Trp-P-1 catalyzed by cytochrome P450 (CYP) 1A subfamily is necessary to show its carcinogenic effects. In the present study, whether the induction of CYP 1A affects cytotoxic and apoptotic effects of Trp-P-1 was investigated using β-naphthoflavone (β-NF) pretreated rats hepatocytes. Pretreatment with β-NF of rats suppressed Trp-P-1-induced apoptosis in primary cultured hepatocytes. In the same cultures, metabolites of Trp-P-1 were increased. These results suggest that intact Trp-P-1 but not its metabolites induce apoptosis in hepatocytes.
ChemInform Abstract: Palladium‐Catalyzed Preparation of Silyl Enolates from α,β‐Unsaturated Ketones or Cyclopropyl Ketones with Hydrosilanes. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Distribution of First-Detected Atrial Fibrillation Patients Without Structural Heart Diseases in Symptom Classifications (2012)

This is the first report to describe the distribution, characteristics and outcomes of first-detected AF patients according to symptom classifications.
Enzymatic Degradation of Model Cellulose Film Pre-Treated with Antimicrobial Agent (2009)

Enzymatic degradation of model cellulose films pre-treated with antimicrobial agent, 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride (TMPAC) was investigated. AFM topographical imaging was used to assess the surface morphology, roughness, and thickness of the dried and hydrated model cellulose film. The kinetics of the model cellulose film in the hydrated state, the adsorption of TMPAC onto the film followed by desorption given by an enzyme extracted from Trichoderma Viride were studied by in situ null ellipsometry. The results show that the adsorption of TMPAC onto model cellulose film slows down the rate of degradation, as confirmed by a slower decrease in the film mass and by different behaviour of the thickness of the film pre-treated with antimicrobial agent in comparison with pure model cellulose film.
Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression (2012)

It is known that genetic variants can affect gene expression, but it is not yet completely clear through what mechanisms genetic variation mediate this expression. We therefore compared the cis-effect of single nucleotide polymorphisms (SNPs) on gene expression between blood samples from 1,240 human subjects and four primary non-blood tissues (liver, subcutaneous, and visceral adipose tissue and skeletal muscle) from 85 subjects. We characterized four different mechanisms for 2,072 probes that show tissue-dependent genetic regulation between blood and non-blood tissues: on average 33.2% only showed cis-regulation in non-blood tissues; 14.5% of the eQTL probes were regulated by different, independent SNPs depending on the tissue of investigation. 47.9% showed a different effect size although they were regulated by the same SNPs. Surprisingly, we observed that 4.4% were regulated by the same SNP but with opposite allelic direction. We show here that SNPs that are located in transcriptional regulatory elements are enriched for tissue-dependent regulation, including SNPs at 3' and 5' untranslated regions (P = 1.84×10(-5) and 4.7×10(-4), respectively) and SNPs that are synonymous-coding (P = 9.9×10(-4)). SNPs that are associated with complex traits more often exert a tissue-dependent effect on gene expression (P = 2.6×10(-10)). Our study yields new insights into the genetic basis of tissue-dependent expression and suggests that complex trait associated genetic variants have even more complex regulatory effects than previously anticipated.
Wavefront control in the design of narrow-and broad-band optical coatings (2019)

The wavefront distortion induced by some optical coatings has often been underestimated with serious consequences in the performance of optical instruments. The typical approach to face such inconvenience consists in modifying the shape of the coated optics by compensating either the bending induced by stress or the geometrical thickness variations in nonuniform coatings. A relevant contribution to the wavefront distortion can also be given by the interference in the coating layers and a standard approach to overcome such problem is not available. In this work the wavefront deformation that is due to the spatial non-uniformity of thin-film optical coatings is analyzed, with the aim of identifying simple structures in which the influence of thickness non-uniformity on the wavefront shape is minimized. Some examples are reported especially for high-reflectance coatings.
The Case of the Missing Lower Trapezius Muscle (2011)

The patient was a 22-year-old male physical therapy student whose tutor suspected the absence of the lower portion of the left trapezius muscle. During left lower trapezius manual muscle testing, it was noted that he was unable to achieve satisfactory control of the left scapula and the left lower trapezius was visibly and palpably absent compared to the right side. Because absence of the lower trapezius muscle was suspected, magnetic resonance imaging was completed to confirm its absence. J Orthop Sports Phys Ther 2011;41(8):614. doi:10.2519/jospt.2011.0416
Field Test and Demonstration of an Advanced Integrated Multi-Sensor System (2011)

This paper discusses the development, assembly, integration, and field-testing of the Advanced Integrated Multisensor System (AIMS) as a demonstration unit of a prospective surveillance system. The AIMS single-platform design incorporated multiple passive sensors, including visible, near-IR, mid and long-wave (MWIR and LWIR) detectors with a laser module performing an active tracking of a remote target. AIMS uses a set of the signals detected by a set of imaging and non-imaging sensors to lock onto a target and continuously track its path or flight trajectory. The shared optical train employed in the AIMS design, simplified issues associated with spatial correlation and temporal synchronization of sensor array information. This enables effective matching and fusion of sensor data and enables more effective target identification, characterization/attribution and discrimination. A Kalman filter technique was applied to derive target trajectory and establish fixed tracking. By demonstrating the successful system performance against a ground-based target at a range of 6.4 km and an airborne target at 4.3 km we proved the AIMS concept. When fully developed AIMS can support surveillance operations in both passive and active modes.
Stereoselective Pincer-Complex Catalyzed C-H Functionalization of Benzyl Nitriles under Mild Conditions. An Efficient Route to β-Aminonitriles (2008)

An efficient palladium pincer-complex catalyzed reaction has been developed for alpha-C-H bond functionalization of benzyl nitriles. The studied coupling reaction with sulfonylimines affords beta-aminonitriles with usually high levels of stereoselectivity. The stereoselectivity of the process is highly dependent on the electronic effects of the ortho substituents of the benzyl moiety. Promising levels of enantiomeric excess are obtained using chiral pincer complexes as catalysts.
Epidemiology, Antimicrobial Resistance, and Virulence Determinants of Group B Streptococcus in an Australian Setting (2022)

<i>Streptococcus agalactiae</i> [group B <i>Streptococcus</i> (GBS)] is a major neonatal pathogen and also causes invasive disease in non-pregnant adults. One hundred GBS isolates (<i>n</i> = 50 invasive disease and <i>n</i> = 50 colonizing pregnant women) were characterized using capsular serotyping by latex agglutination, antimicrobial susceptibility testing, and whole genome sequencing (WGS). All isolates were susceptible to penicillin, 32% were resistant to clindamycin. Of these, two isolates had reduced susceptibility to ceftriaxone (MIC 0.75 mg/L) and were found to have unique alleles at <i>pbp2X</i> and <i>pbp1A</i>. Capsular serotypes Ia (18%), III (18%), Ib (14%), V (12%), and VI (11%) were most common and comparison of latex agglutination and capsular genotyping by WGS showed 71% agreement. Less common capsular genotypes VI-VIII represented 15% of isolates, indicating that a significant proportion may not be targeted by the proposed pentavalent or hexavalent vaccines under development. WGS is a useful aid in GBS surveillance and shows correlation to phenotypic serotyping and antimicrobial susceptibility data.
Privilege Management of Mobile Agents (2000)

: Most mobile agent systems use internal data structures within an agent to control and specify its security requirements and properties. These structures typically contain authorization information regarding access to computational resources on distributed systems and conceptually serve as an internal passport for the agent. While these structures are often very similar semantically, they differ greatly in their implementation, depending to a large extent on the mechanisms used to protect their contents. This paper considers a general scheme for managing privileges using attribute certificates. An attribute certificate can be viewed as an external, digitally signed agent passport, which allows greater flexibility in meeting the needs of an application and overlaying a suitable management scheme. The paper presents the benefits of this approach and gives an example of how an agent system could be enhanced with this mechanism.