gebhart/patrepeval huggingface dataset:
NaYF4:Yb,Er/NaYF4 Core/Shell Nanocrystals with High Upconversion Luminescence Quantum Yield (2018)

Upconversion core/shell nanocrystals with different mean sizes ranging from 15 to 45 nm were prepared via a modified synthesis procedure based on anhydrous rare-earth acetates. All particles consist of a core of NaYF<sub>4</sub> :Yb,Er, doped with 18 % Yb<sup>3+</sup> and 2 % Er<sup>3+</sup> , and an inert shell of NaYF<sub>4</sub> , with the shell thickness being equal to the radius of the core particle. Absolute measurements of the photoluminescence quantum yield at a series of different excitation power densities show that the quantum yield of 45 nm core/shell particles is already very close to the quantum yield of microcrystalline upconversion phosphor powder. Smaller core/shell particles prepared by the same method show only a moderate decrease in quantum yield. The quantum yield of 15 nm core/shell particles, for instance, is reduced by a factor of three compared to the bulk upconversion phosphor at high power densities (100 W cm<sup>-2</sup> ) and by approximately a factor of 10 at low power densities (1 W cm<sup>-2</sup> ).
Effects of integration and replication on transcription of the HIV-1 long terminal repeat. (1993)

The activity of a promoter is influenced by chromosomal and cell cycle/replication context. We analyzed the influences of integration and replication on transcription of the human immunodeficiency virus (HIV)-1 long terminal repeat (LTR). We found that one requirement for Tat trans-activated expression differed for integrated versus unintegrated HIV-1 LTR. Specifically, the second coding exon of Tat, previously regarded as functionally dispensable, plays a role in the optimal activation of integrated LTRs. We also found that the transcription profile produced from the HIV-1 LTR is influenced by replication. Autonomously replicating vectors that contain the HIV-1 LTR produced patterns of transcription different from counterpart vectors that do not replicate. Both replicating and nonreplicating HIV-1 LTRs remained responsive to Tat.
New Imidazole Alkaloids From the Sponge Leucetta sp. and the Associated Predatory Nudibranch Notodoris gardineri (1993)

Three new imidazole alkaloids, naamidines Eand F and clathridine C, have been isolated from a sponge Leucetta sp., together with the known imidazole alkaloids naamidine A, pyronaamidine, clathridine and kealiiquinone. The predatory nudibranch Notodoris gardineri, which was found feeding on the sponge, contained the known metabolite clathridine. The structures of all compounds were delineated on the basis of one-dimensional and two-dimensional n.m.r. experiments at 300 MHz.
Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress (2013)

We propose that cytarabine-based chemotherapy regimens may represent a tumour-selective treatment strategy for mismatch repair-deficient cancers.
The Chinese in the United States of America (1961)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Real-time video rate imaging with a 1k-pixel THz CMOS focal plane array (2012)

Future submillimeter-wave and THz (300GHz-3THz) imaging applications will require low-cost portable systems operating at room-temperature with a video-rate speed and capable of delivering acceptable sensitivity at the very low-power consumption levels to become attractive for truly commercial applications. In particular, CMOS technologies are of interest due to their high integration level offered at a high yield that is capable of massive cost reduction of currently existing THz systems. It has been recently demonstrated that CMOS direct detectors achieve the performance comparable or even superior to the today's existing classical THz devices for active imaging operating at room-temperature. So far, however, only single pixels have been used, allowing only a raster-scan operation. To address this obstacle, we present the very initial work on a 1k-pixel camera chip with a completely integrated readout circuitry and with a full video-rate capability at a power consumption of 2.5&mu;W/pixel. The chip is fully compliant with an industrial bulk CMOS technology and it is intended for active imaging applications. It exhibits a pixel pitch of 80&#956;m, defined by a novel on-chip wire ring antenna, and is designed to accommodate silicon hyper-hemispherical lens for a wide operation bandwidth of at least 0.7-1.1 THz.
Calculating medium and image gamut boundaries for gamut mapping (2000)

The Segment Maxima Method for calculating gamut boundary descriptors of both colour reproduction media and colour images is introduced. Methods for determining the gamut boundary along a given line of mapping used by gamut mapping algorithms are then described, whereby these methods use the Gamut Boundary Descriptor obtained using the Segment Maxima Method. Throughout the article, the focus is both on colour reproduction media and colour images as well as on the suitability of the methods for use in gamut mapping. © 2000 John Wiley & Sons, Inc. Col Res Appl, 25, 394–401, 2000
Promiscuous Anticancer Drugs from Pathogenic Bacteria: Rational Versus Intelligent Drug Design (2010)

This chapter contains sections titled: Introduction Promiscuous Drugs Targeting Multiple Steps in Cancer Growth Progression Anticancer Activity of Pa-Caspase Recruitment Domain and Pa-Arginine Deiminase References
A Method for Guaranteeing End-to-End Delay by Mutual Cooperation between IP Routers (2005)

Various real-time applications are widely used with the development of network infrastructure. To guarantee QoS(Quality of Service) of these applications strictly, the Internet will require a flow-based priority control. Thus, we have proposed an output buffer control mechanism. In this paper, to guarantee End-to-End QoS maximally by exploiting the buffer control mechanism, we propose the method of mutual cooperation between IP routers equipped with our mechanism by using one of the signaling protocols. In addition, we show the effectiveness of our proposal by computer simulation.
A Logical Framework for Systems Biology (2014)

We propose a novel approach for the formal verification of biological systems based on the use of a modal linear logic. We show how such a logic can be used, with worlds as instants of time, as an unified framework to encode both biological systems and temporal properties of their dynamic behaviour. To illustrate our methodology, we consider a model of the P53/Mdm2 DNA-damage repair mechanism. We prove several properties that are important for such a model to satisfy and serve to illustrate the promise of our approach. We formalize the proofs of these properties in the Coq Proof Assistant, with the help of a Lambda Prolog prover for partial automation of the proofs.
Prevalence and Characterization of Shiga Toxin-Producing and Enteropathogenic Escherichia coli in Shellfish-Harvesting Areas and Their Watersheds (2015)

more strains formed a strong biofilm at 18 than at 30°C. Finally, more than 85% of analyzed strains were found to be sensitive to the 16 tested antibiotics. These data suggest the low risk of human infection by STEC if shellfish from these shellfish-harvesting areas were consumed.
An Introduction to the Mechanics of Tensegrity Structures (2017)

Tensegrity structures consist of strings (in tension) and bars (in compression). Strings are strong, light, and foldable, so tensegrity structures have the potential to be light but strong and deployable. Pulleys, NiTi wire, or other actuators to selectively tighten some strings on a tensegrity structure can be used to control its shape. This chapter describes some principles we have found to be true in a detailed study of mathematical models of several tensegrity structures. We describe properties of these structures which appear to have a good chance of holding quite generally. We describe how pretensing all strings of a tensegrity makes its shape robust to various loading forces. Another property (proven analytically) asserts that the shape of a tensegrity structure can be changed substantially with little change in the potential energy of the structure. Thus, shape control should be inexpensive. This is in contrast to control of classical structures which require substantial energy to change their shapes. A different aspect of the chapter is the presentation of several tensegrities that are light but extremely strong. The concept of self-similar structures is used to find minimal mass subject to a specified buckling constraint. The stiffness and strength of these structures are determined.
Africa's International Rivers (2003)

Cooperative management, and development of Africa's international rivers holds real promise for greater sustainability, and productivity of the continent's increasingly scarce water resources, and fragile environment. Moreover, the potential benefits of cooperative water resources management, can serve as catalysts for broader regional cooperation, economic integration, and development - and even conflict prevention. But riparians will pursue joint action only when they expect to receive greater benefits through cooperation than through unilateral action. Economic analysis can be used to make the case for cooperation on international rivers, using tools that will help identify, and measure the potential incremental benefits of cooperation, determine the distribution of benefits among riparians, and assess the feasibility, and fairness of alternative management, and investment scenarios. Where such schemes yield benefit distributions, not perceived as equitable among riparians, economic tools could also be used to calculate, design, and implement arrangements for redistribution. In all of these ways, economics can play an important role in enabling the management of international rivers, helping to motivate, design, and implement cooperative water resources management.
Face detection and tracking for video coding applications (2002)

In video communication applications at low bitrates, coding artifacts are especially disturbing in face areas. Encoding faces with higher quality than background regions requires automatic face detection. This paper presents a robust face segmentation and tracking algorithm and investigates the application to region-of-interest coding with H.263+ and object-based coding with MPEG-4.
Investigation of the distribution of laser damage precursors at 1064 nm, 12 ns on Niobia-Silica and Zirconia-Silica mixtures (2012)

Simple Nb(2)O(5), ZrO(2), SiO(2) oxide coatings and their mixtures with SiO(2) have been prepared by the Ion Beam Sputtering (IBS) technique. The Laser-Induced Damage of these samples has been studied at 1064 nm, 12 ns. The laser induced damage threshold (LIDT) decreases in both sets of the mixtures with the volumetric fraction of high index material. We find that the nanosecond LIDT of the mixtures is related to the band gap of the material as it has been widely observed in the subpicosecond regime. The laser damage probability curves have been fitted firstly by a statistical approach, i.e. direct calculation of damage precursor density from damage probability and secondly by a thermal model based on absorption of initiator. The distributions of damage precursors versus fluence extracted from these fittings show a good agreement. The thermal model makes it possible to connect damage probability to precursor physical properties. A metallic defect with a maximum radius of 18 nm was proposed to the interpretation. The critical temperature in the laser damage process exhibited a dependence on the band-gap of the material.
A diabetes prevention assessment tool for American Indians. (2005)

Our diabetes assessment tool identified factors that should be considered when developing health promotion and diabetes prevention programs for American Indians. A valid assessment tool for the American Indian population could provide valuable, formative data that would increase understanding of the culturally related obstacles to health promotion and diabetes prevention.
Flexible Solid-State Electrolyte with Aligned Nanostructures Derived from Wood (2019)

Solid-state Li-batteries (SSLiBs) with solid-state electrolytes (SSEs) can potentially block Li dendrite penetration, enabling the application of metallic lithium anodes to achieve high energy density with improved safety. The ion transport behavior and ionic conductivity in Li-ion batteries is significantly influenced by the tortuosity of the electrode and electrolyte materials. Low-tortuosity structures with straight ion pathways are highly desirable yet very difficult to achieve in solid-state ion conductors. Templating from wood, for the first time, we developed a highly conductive garnet framework with multiscale aligned mesostructure through a scalable, top-down approach. Ion-conductive poly(ethylene oxide) (PEO) was incorporated into the mesoporous, wood-templated aligned garnet nanostructure, resulting in a flexible solid-state composite electrolyte. The synergistic integration of the aligned garnet with soft, mechanically robust polymer results in both a high ionic conductivity (1.8 × 10–4 S/cm at room temperature) and good mechanical flexibility. This work provides a new direction for developing low-tortuosity, fast ion conductors inspired by nature.
Paradoxical Sleep in Mice Lacking M<sub>3</sub> and M<sub>2</sub>/M<sub>4</sub> Muscarinic Receptors (2005)

Acetylcholine is crucial for the regulation of paradoxical sleep (PS) and EEG theta activity. To determine the contribution of individual muscarinic receptors to these events, we analyzed the sleep-waking cycle and EEG activities of mice lacking functional M(3) or M(2)/M(4 )receptors. Daily PS amounts were significantly decreased in M3-/- (-22%) but not in M2/M4-/- mice. Further, the theta peak frequency for PS was significantly increased in both M2/M4-/- and M3-/- mice. This study supports the potential role of M(3) rather than M(2) and M(4) muscarinic receptors in the modulation of PS in mice and strengthens the idea that multiple muscarinic receptors contribute to the regulation of the EEG theta activity during PS.
Bioavailability of trospium chloride after intravesical instillation in patients with neurogenic lower urinary tract dysfunction: A pilot study (1999)

Oral drug treatment of detrusor overactivity often causes undesirable side effects in other organs. For some patients, in particular those with neurogenically induced detrusor overactivity (detrusor hyperreflexia), the tolerance level for adverse effects is low and oral treatment may become ineffective. Intravesical administration of the drug can diminish the side effects or increase treatment effectivity in patients who are (partially) refractory to oral treatment because the relative concentration of the drug is increased in the target organ and decreased in the circulation. Six men (19–34 years old) with traumatic spinal cord lesions between C2 and Th11 were randomized to intravesical instillation with 15 or 30 mg trospium chloride in 40 ml saline into the empty bladder. Catheterization was postponed until at least 3 h after instillation, and fluid intake was not allowed during the first 4 h. Blood samples were taken before and 11 times after instillation; the last sample 12 h post instillation. Four positive samples were found in three patients: 0.10 ng/ml after 1 h and 0.13 ng/ml after 2½ h in two patients with 15 mg, and 0.24 ng/ml after 30 min and 0.70 ng/ml after 6 h in one patient with 30 mg instilled trospium chloride. Three adverse effects were reported and were rated as probably not related to the drug. It is concluded that intravesically instilled trospium chloride is not absorbed into the circulation in significant amounts and, thus, it may be expected that this mode of administration will improve the efficacy of trospium chloride therapy by reducing the side effects. Neurourol. Urodynam. 18:447–453, 1999. © 1999 Wiley-Liss, Inc.
How good is a span of terms? (2010)

Ranking search results is a fundamental problem in information retrieval. In this paper we explore whether the use of proximity and phrase information can improve web retrieval accuracy. We build on existing research by incorporating novel ranking features based on flexible proximity terms with recent state-of-the-art machine learning ranking models. We introduce a method of determining the goodness of a set of proximity terms that takes advantage of the structured nature of web documents, document metadata, and phrasal information from search engine user query logs. We perform experiments on a large real-world Web data collection and show that using the goodness score of flexible proximity terms can improve ranking accuracy over state-of-the-art ranking methods by as much as 13%. We also show that we can improve accuracy on the hardest queries by as much as 9% relative to state-of-the-art approaches.
COVID-19 THROMBUS STORM: VENOUS, ARTERIAL, CORONARY, AND CARDIAC CLOTS (2023)

Background:The increased prothrombotic state is observed with COVID.We are presenting a case who developed venous, arterial, coronary, and cardiac clots despite being on anticoagulation.Case: A healthy 60-year-old male presented with chest pain.He tested positive for COVID on admission.He was tachycardic and normoxic, EKG revealed anterolateral ischemia.Troponin elevated to 8.08ng/ml.CTA lung showed lower lobe segmental pulmonary embolism.U/S revealed bilateral lower extremity DVT.He denied any substance abuse or family history of thrombosis.Decision-making: TTE revealed LVEF 40-45% after which coronary angiography was pursued and revealed a Left anterior descending artery distal small thrombus that was felt best treated medically.The patient was discharged on ticagrelor and Apixaban.The Patient was admitted later on for a large MCA stroke and a repeat TTE revealed a tricuspid valve thrombus despite compliance with anticoagulation.Patient was transitioned to comfort measures only. Conclusion:Maintain a low threshold for thrombosis in patients with COVID even if it is mild.Despite anticoagulation/antiplatelet therapy, Thromboembolism can still be progressive and fatal.
Elk-1 associates with the mitochondrial permeability transition pore complex in neurons (2006)

The nuclear transcription factor E-26-like protein 1 (Elk-1) is thought to impact neuronal differentiation [Sharrocks, A. D. (2001) Nat. Rev. Mol. Cell Biol. 2, 827-837], cell proliferation [Sharrocks, A. D. (2002) Biochem. Soc. Trans. 30, 1-9], tumorigenesis [Chai, Y. L., Chipitsyna, G., Cui, J., Liao, B., Liu, S., Aysola, K., Yezdani, M., Reddy, E. S. P. & Rao, V. N. (2001) Oncogene 20, 1357-1367], and apoptosis [Shao, N., Chai, Y., Cui, J., Wang, N., Aysola, K., Reddy, E. S. P. & Rao, V. N. (1998) Oncogene 17, 527-532]. In addition to its nuclear localization, Elk-1 is found throughout the cytoplasm, including localization in neuronal dendrites [Sgambato, V., Vanhoutte, P., Pages, C., Rogard, M., Hipskind, R., Besson, M. J. & Caboche, J. (1998) J. Neurosci. 18, 214-226], raising the possibility that Elk-1 may have alternative extranuclear functions in neurons. Using coimmunoprecipitation and reciprocal coimmunoprecipitation from adult rat brain, we found an association between Elk-1 protein and the mitochondrial permeability transition pore complex (PTP), a structure involved in both apoptotic and necrotic cell death. Electron microscopy in adult rat brain sections confirmed this association with mitochondria. Elk-1 was also identified from purified mitochondrial fractions by using Western blotting, and Elk-1 increased its association with mitochondria following proapoptotic stimuli. Consistent with a role for Elk-1 in neuron viability, overexpression of Elk-1 in primary neurons decreased cell viability, whereas Elk-1 siRNA-mediated knockdown increased cell viability. This decrease in viability induced by Elk-1 overexpression was blocked with application of a PTP inhibitor. These results show an association of the nuclear transcription factor Elk-1 with the mitochondrial PTP and suggest an additional extranuclear function for Elk-1 in neurons.
Retardation of Hair Regrowth, a Phenomenon of Senescence in C57B1/6J Male Mice (1973)

Journal Article Retardation of Hair Regrowth, a Phenomenon of Senescence in C57B1/6J Male Mice Get access Caleb E. Finch, PhD Caleb E. Finch, PhD 2Department of Anatomy, Cornell University Medical College, New York. Currently at the Andrus Gerontology Center, University of Southern CaliforniaLos Angeles 90007 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Gerontology, Volume 28, Issue 1, January 1973, Pages 13–17, https://doi.org/10.1093/geronj/28.1.13 Published: 01 January 1973
Validated 5‐point photonumeric scales for the assessment of the periorbital region (2021)

The created scales to assess infraorbital hollowing, dynamic and static crow's feet have been shown to provide substantial to almost perfect agreement in the digital and live validation and can thus be considered as helpful tools in the clinical and research setting. While technical methods and appliances to assess the degrees of severity of age-dependent features are advancing, validated scales are of great importance due to their ease of use and, as shown by the validations, reliability, and reproducibility.
Robust Phase Behavior of Model Transient Networks (2001)

To study the viscoelastic properties of certain complex fluids which are described in terms of a multiconnected transient network, we have developed a convenient model system composed of microemulsion droplets linked by telechelic polymers. The phase behavior of such systems has two characteristic features: a large monophasic region which consists of two subregions (a fluid sol phase and a viscoelastic gel phase) separated by a percolation line and a two-phase region at low volume fraction with separation into a dilute sol phase and a concentrated gel phase. From the plausible origin of these features we expect them to be very similar in different systems. We describe here the phase behavior of four different systems we prepared in order to vary the time scale of the dynamical response of the transient network: they consist of the combination of two oil (decane) in water microemulsions differing by the stabilizing surfactant monolayer (cetylpyridinium chloride/octanol or TX100/TX35) and of two telechelic polymers which are end-grafted poly(ethylene oxide) chains, differing by the end-grafted hydrophobic aliphatic chains (C12H25 or C18H37). We first summarize the characterization of the structure of the four systems by small angle neutron scattering: the size of the microemulsion droplets is found to be constant in a given system upon addition of a telechelic polymer. In the CPCl systems we find a mean radius of the microemulsion droplets of 62 ± 1 Å and a very narrow size distribution, and in the TX systems we find a mean radius of 84 ± 2 Å and a somewhat larger size distribution. We can then calculate precisely the number of polymers per microemulsion droplet and compare the phase behavior of the four systems in consistent units. As expected, we find very similar phase behavior in the four systems.
Glycogen synthase kinase-3 represses cyclic AMP response element-binding protein (CREB)-targeted immediate early genes in quiescent cells. VOLUME 282 (2007) PAGES 9482-9491 (2007)

PAGE 9482: In the Introduction, right column, 8th line: “GSK-3α” was misspelled. The line should read: “... phosphorylation by Akt of GSK-3β on serine 9 or GSK-3α on serine 21 (2).”
Cerebral infarction due to painless thoracic aortic and common carotid artery dissections. (1993)

This case emphasizes the usefulness of new noninvasive techniques such as transesophageal echocardiography and color-coded Doppler echocardiography in the diagnosis and follow-up of painless dissection of aortic and common carotid arteries. This cause of stroke may be underestimated.