gebhart/patrepeval huggingface dataset:
Electrodialytic membrane suppressor for ion chromatography (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrodialytic membrane suppressor for ion chromatographyDouglas L. Strong and Purnendu K. DasguptaCite this: Anal. Chem. 1989, 61, 9, 939–945Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/ac00184a005https://doi.org/10.1021/ac00184a005research-articleACS PublicationsRequest reuse permissionsArticle Views253Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antibody-mediated inhibition of Bordetella pertussis adenylate cyclase–haemolysin-induced macrophage cytotoxicity is influenced by variations in the bacterial population (2014)

Whooping cough is a vaccine-preventable disease presenting with epidemic cycles linked to natural and/or vaccine-driven evolution of the aetiological agent of the disease, Bordetella pertussis. Adenylate cyclase-haemolysin (AC-Hly) is a major toxin produced by this pathogen, which mediates macrophage apoptosis in vitro and in vivo. While current acellular pertussis vaccine (APV) formulations do not include AC-Hly, they all contain pertussis toxin and can comprise filamentous haemagglutinin (FHA), which interacts with AC-Hly, and pertactin (PRN), which has been hypothesized also to interact with AC-Hly. We aimed to study the capacity of specific antibodies to inhibit the in vitro B. pertussis AC-Hly-mediated cytotoxicity of J774A.1 murine macrophages in a background of a changing bacterial population. We demonstrate that: (i) clinical isolates of different types or PRN phenotype are all cytotoxic and lethal in the mouse model of respiratory infection; (ii) lack of PRN production does not impact AC-Hly-related phenotypes; (iii) anti-AC-Hly antibodies inhibit cell lysis whatever the phenotype of the isolate, while anti-PRN antibodies significantly inhibit cell lysis provided the isolate produces this antigen, which might be relevant in vivo for APV-induced immunity; and (iv) anti-FHA antibodies only inhibit lysis induced by isolates collected in 2012, maybe indicating specific characteristics of epidemic lineages of B. pertussis.
A step‐wise approach to define binding mechanisms of surrogate viral particles to multi‐modal anion exchange resin in a single solute system (2017)

Multi-modal anion exchange resins combine properties of both anion exchange and hydrophobic interaction chromatography for commercial protein polishing and may provide some viral clearance as well. From a regulatory viral clearance claim standpoint, it is unclear if multi-modal resins are truly orthogonal to either single-mode anion exchange or hydrophobic interaction columns. To answer this, a strategy of solute surface assays and High Throughput Screening of resin in concert with a scale-down model of large scale chromatography purification was employed to determine the predominant binding mechanisms of a panel of bacteriophage (i.e., PR772, PP7, and ϕX174) to multi-modal and single mode resins under various buffer conditions. The buffer conditions were restricted to buffer environments suggested by the manufacturer for the multi-modal resin. Each phage was examined for estimated net charge expression and relative hydrophobicity using chromatographic based methods. Overall, PP7 and PR772 bound to the multimodal resin via both anionic and hydrophobic moieties, while ϕX174 bound predominantly by the anionic moiety. Biotechnol. Bioeng. 2017;114: 1487-1494. © 2017 Wiley Periodicals, Inc.
Physiology of IgD III. Effect of treatment with anti‐IgD from birth on the magnitude and isotype distribution of the immune response in the spleen (1984)

Continued treatment with monoclonal anti-IgD (Ig-5a) from birth in BALB/c mice causes a markedly increased responsiveness to i.v. injected dinitrophenylated ovalbumin (DNP-OVA) with Bordetella pertussis at the age of 8 weeks. The 19S plaque-forming cell (PFC)/spleen response is particularly enhanced, 6-8-fold, but all the other isotypes also show increases of 2-6-fold, including IgA and IgE. Both primary and secondary PFC responses and serum antibody titers are enhanced. After transfer of spleen cells from anti-Ig-treated mice to irradiated recipients the IgM/IgG ratio becomes similar to that of controls. In contrast, the response of anti-IgD-treated mice to i.p. immunization with either 0.2 or 100 micrograms DNP-OVA plus alum is reduced by approximately 80% for each Ig isotype except IgM and remains low upon transfer of spleen cells to recipients. It is concluded that the paucity of B cells in peripheral lymph nodes of the anti-IgD-treated mice causes the low responsiveness to i.p. immunization, but that the IgD- B cells in the spleen are quite able to respond and are, in fact, more responsive than IgD+ B cells. This increased responsiveness, together with the higher IgM/IgG ratios for all Ig isotypes and an otherwise similar order of isotype distribution (gamma 1 greater than gamma 2b greater than gamma 2a = epsilon greater than or equal to alpha) as in controls, suggests that a hyperresponsive, but less mature IgD- B cell population is selectively produced in the spleens of mice treated with anti-IgD from birth.
Layered Halide Double Perovskites Cs3+nM(II)nSb2X9+3n (M = Sn, Ge) for Photovoltaic Applications (2017)

Over the past few years, the development of lead-free and stable perovskite absorbers with excellent performance has attracted extensive attention. Much effort has been devoted to screening and synthesizing this type of solar cell absorbers. Here, we present a general design strategy for designing the layered halide double perovskites Cs<sub>3+n</sub>M(II)<sub>n</sub>Sb<sub>2</sub>X<sub>9+3n</sub> (M = Sn, Ge) with desired photovoltaic-relevant properties by inserting [MX<sub>6</sub>] octahedral layers, based on the principles of increased electronic dimensionality. Compared to Cs<sub>3</sub>Sb<sub>2</sub>I<sub>9</sub>, more suitable band gaps, smaller carrier effective masses, larger dielectric constants, lower exciton binding energies, and higher optical absorption can be achieved by inserting variable [SnI<sub>6</sub>] or [GeI<sub>6</sub>] octahedral layers into the [Sb<sub>2</sub>I<sub>9</sub>] bilayers. Moreover, our results show that adjusting the thickness of inserted octahedral layers is an effective approach to tune the band gaps and carrier effective masses in a large range. Our work provides useful guidance for designing the promising layered antimony halide double perovskite absorbers for photovoltaic applications.
Mitochondrial DNA polymerase ? deficiency and mtDNA depletion in a child with Alpers' syndrome (1999)

Deficiency of mitochondrial DNA polymerase gamma activity was found in a patient with mtDNA depletion and Alpers' syndrome. Metabolic evaluation revealed fasting hypoglycemia, dicarboxylic aciduria, and reduced activity of the electron transport chain in skeletal muscle. The patient died in early childhood of fulminant hepatic failure, refractory epilepsy, lactic acidemia, and coma. mtDNA content was 30% of normal in skeletal muscle and 25% in the liver. The activity of mtDNA polymerase gamma was undetectable.
Numerical Evaluation of the Role of Reflectors to Maximize the Power Efficiency of an Axial Vircator (keynote) (2013)

International audience
Switching Facilities in MPEG-2: Necessary but Not Sufficient (1995)

MPEG-2 provides a number of facilities intended to permit the time concatenation of separately compressed program segments through the assemble and insert editing of those segments downstream from their encoding or release points. Such facilities are necessary to support some of the mechanical aspects of switching between segments in the assembly of programs and other continuity elements for release and in the downstream insertion of commercials. But the switching hooks provided in MPEG-2 transport stream packetization, however necessary they may be, are not sufficient to the task. Several operational steps must be taken for continuity integration to succeed in producing a smoothly flowing output without the appearance of a “channel change ” at the switching points. Indeed, for the successful integration of material encoded at different locations, these operational steps must be precisely defined and standardized. This paper examines the supporting functions provided by MPEG-2 and will suggest a number of areas in which agreement must be reached on operations practices before successful networks can be built.
Quasielastic laser light scattering of phosphatidylcholine vesicles (1976)

Experiments are reported on the angular and the spectral distribution of scattered light for phosphatidylcholine vesicles formed by ultrasonic irradiation under nitrogen in 1 mM CsCl(D2O) solution and subsequent filtration using a VCWP 01300 millipore filter of 1000 Å nominal pore size. Analysis of the time-dependent single-clipped photocount autocorrelation function reveals that a trace amount of about one part per thousand of relatively polydispersed large fragments with an estimated average size of about 1.1×103 Å is contaminating the smaller vesicles. The trace contaminants are very difficult to detect by other more standard methods, such as ultracentrifugation and gel permeation chromatography. Furthermore, the cumulant method is not likely to yield a quantitative determination of the diffusion coefficient and the size of the main vesicle component because very small amounts of large particles actually contribute significantly to light scattering. We have resolved the time-correlation function into two exponentials. By assuming that the phosphatidylcholine vesicles behave like Stokes spheres, we have obtained a reasonable value of 3.1×102 Å as the average diameter of those vesicle spheres.
Characterization of a modified Bosch-type process for silicon mold fabrication (2005)

We present the results of our development of a deep silicon etching technique, the modified Bosch-type process. Its feasibility was also investigated. This modified Bosch-type process is based on the well known Bosch-type process, but our modified Bosch-type process consists of the etching/passivating time, process transition step, and ion energy control. This modified Bosch-type process has been characterized with respect to ion energy, substrate temperature, and feature size. We found that the etching and deposition characteristics of passivating film were closely related to the resulting deep silicon etch profile. Up to a 40–50 μm deep silicon structure with vertical and positively sloped profiles was realized by the modified Bosch-type process, depending on a few parameters. In this work, this modified Bosch-type process was applied to silicon mold fabrication used for a structuring microarray and optical power splitter. Replication results confirm that this process is promising for achieving high-yield, reliable microstructures on polymer films.
Preparation of 2-Isopropyloestradiol (1988)

A simple route to 2-alkyloestradiols is demonstrated by the conversion of oestradiol into its 2-isopropyl derivative.
Edible Oils for Liver Protection: Hepatoprotective Potentiality of Moringa Oleifera Seed Oil against Chemical‐Induced Hepatitis in Rats (2012)

In the present study, in vitro antioxidant, antioxidative stress and hepatoprotective activity of Moringa oleifera Lam. seed oil (Ben oil; BO) was evaluated against carbon tetrachloride (CCl(4) ) induced lipid peroxidation and hepatic damage in rats. The oil at 0.2 and 0.4 mL/rat was administered orally for 21 consecutive days. The substantially elevated serum enzymatic (GOT, GPT, ALP, GGT) and bilirubin levels were significantly restored towards normalization by the oil. There was a significant elevation in the level of malondialdehyde (MDA), non-protein sulfhydryl (NP-SH), and total protein (TP) contents in the liver tissue. The results obtained indicated that BO possesses potent hepatoprotective action against CCl(4) -induced hepatic damage by lowering liver marker enzymes, MDA concentration, and elevating NP-SH and TP levels in liver tissue. The biochemical observations were supplemented with histopathological examination of rat liver. The results of this study showed that treatment with Ben oil or silymarin (as a reference) appears to enhance the recovery from hepatic damage induced by CCl(4) . The pentobarbital induced narcolepsy prolongation in mice was retarded by the Ben oil. Acute toxicity test in mice showed no morbidity or mortality. In vitro DPPH radical scavenging and β-carotene-linolic acid assay tests of the BO exhibited a moderate antioxidant activity in both tests used. The possible mechanism(s) of the liver protective activity of Ben oil activity may be due to free radical scavenging potential caused by the presence of antioxidant component(s) in the oil. Consequently, BO can be used as a therapeutic regime in treatment of some hepatic disorders.
Demo: an LTE compatible massive MIMO testbed based on OpenAirInterface (2017)

Massive MIMO is one of the key technologies enabling the next generation of wireless communications, offering high spectrum efficiency, saving transceivers energy and providing many other advantages. The OpenAirInterface massive MIMO testbed is the world's first open source LTE compliant base station equipped with large antenna array, which can directly provide services to commercial user equipments (UEs). The testbed performs TDD channel reciprocity calibration to acquire accurate channel state information at transmitter (CSIT). It shows the feasibility of using massive MIMO already in current generation LTE standard by using Transmission mode (TM) 7-10, indicating the possibility of smoothly evolving the wireless network from 4G to 5G. We show here an innovation platform for solving 5G massive MIMO challenges, by giving the possibility of advanced algorithm testing, concept validation, channel measurements, etc.
Texture Changes during Uniaxial Compression of Mg-3Al-1Zn (2004)

The mechanical anisotropy of wrought Mg alloys is very high. For example the yield stress of extruded Mg-3Al-1Zn tested in tension can be as high as twice that obtained in compression [1]. To solve the problems this creates for product design it is necessary to understand the sensitivity of texture to processing parameters. Uniaxial compression tests at different temperatures were performed on cylindrical samples of an extruded Mg-3Al-1Zn bar. The texture during this deformation changes from a situation where all crystal c-axes are nearly perpendicular to the sample axis to one where the c-axes are all nearly parallel to this axis. Compression was stopped at different strains to examine the rate of this texture change. Textures were examined using EBSD measurements. It was found that different mechanisms operate depending on the temperature of deformation and that a variety of textures can be created. Also it was seen that an annealing treatment performed after compression has an influence on the texture. Afterwards the samples were subjected to another uniaxial compression test to examine the influence of texture on room temperature properties.
Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes. (1995)

The aim of this study was to ascertain whether different types of T-cell receptor (TCR)-mediated [Ca2+]i signals could begin to explain the different cellular responses of mature and immature T cells to ligation of the TCR-CD3 complex. Using a digital fluorescence imaging system, we measured and compared [Ca2+]i of individual cells from immature and mature murine T-cell populations following application of CD3-epsilon monoclonal antibody (mAb). Our approach revealed distinctions among developmental subsets which were not seen by previous measurements of [Ca2+]i in bulk cell populations. The CD3-mediated [Ca2+]i responses of individual thymocytes were very complex. Latencies to peak [Ca2+]i varied greatly among thymocytes, but the responses of splenic T cells were synchronized, novel evidence that the timing of [Ca2+]i responses may be an important informative parameter for TCR-CD3 signalling. In addition, among cells responding to CD3 mAb, higher peak [Ca2+]i responses correlated with maturity (CD4+ CD8+ thymocytes < single-positive thymocytes < splenic T cells). Examination of cells from pp59fyn-deficient mice showed that pp59fyn deficiency affects the amplitude and probability, but not the latency or synchrony, of CD3-mediated [Ca2+]i responses of CD4+ CD8+ and CD4+ CD8- thymocytes. All subsets showed equivalent receptor-independent mobilization of [Ca2+]i. These developmentally distinct [Ca2+]i features most probably reflect meaningful developmental changes in how the TCR-CD3 complex couples to intracellular signalling machinery including pp59fyn. By clearly showing how [Ca2+]i responses change during development, these results support the hypothesis that distinctive types of [Ca2+]i responses drive thymocyte differentiation.
Application of Nanotechnology in Extinguishing Agents (2022)

Extinguishing agents are a very important tool in the field of security, both in terms of private and social aspects. Depending on the type of burning substance and place of fire, appropriately prepared and developed solutions should be used. We can distinguish, among others, materials, powders or foaming agents. Modifications introduced into them, including ones based on the achievements in the field of nanotechnology, can improve their safety of use and extend their service life. Such amendments also reduce the costs of production and neutralization of the area after a fire, and increase the fire extinguishing effectiveness. The introduction of nanoparticles allows, e.g., shortening of the fire extinguishing time, reduction of the risk of smoke emission and the toxic substances contained in it, and an increase in the specific surface of particles and thus increasing the sorption of pollutants. The elaborations use metal nanoparticles, e.g., NP-Ag, metal oxides such as NP-SiO<sub>2</sub>, as well as particles of substances already present in extinguishing agents but treated and reduced to nanosize. It should be noted, however, that all changes must lead to obtaining a tool that meets the relevant legal requirements and has appropriate approvals.
1.4× efficiency improvement in transparent-substrate (AlxGa1−x)0.5In0.5P light-emitting diodes with thin (⩽2000 Å) active regions (1999)

Improvement of 1.4× in the external quantum efficiency and luminous efficiency (lm/W) of transparent-substrate (AlxGa1−x)0.5In0.5P/GaP light-emitting diodes is demonstrated. The improvement is accomplished by reducing the thickness of the active layer to ⩽2000 Å and increasing the internal quantum efficiency by using multiple thin (⩽500 Å) active layers. The maximum luminous efficiency achieved is 73.7 lm/W at λp∼615 nm and the maximum external quantum efficiency is 32.0% at λp∼632 nm.
Multicriteria portfolio selection problem: robust assets allocation (2016)

The paper shows how to overcome practical difficulties of using the results of modern portfolio theory linked with high dimensions and the insufficient amount of information available about the input parameters, the factors that make the optimal solution unrobust. The modified mean-variance optimisation model shows that Markowitz's portfolio can be improved. The generalised optimal portfolio problem is formulated as a multicriteria problem. The performance index that presents linear convolution of the chosen criteria is considered. The closed-form solution is given under assumption that net short sales are allowed. In contrast to several known pure mathematical regularisation approaches applied to the portfolio selection problem, the considered portfolio model includes the average trading volume of shares of the portfolio's security for a specified period of time measured as a percentage of its total float number of shares, which is used to quantify the portfolio's components based on their potential price increase. The offered additional criterion, which has a clear economic interpretation allows investors to build portfolios that are more robust compared to mean-variance portfolios.
Emile: A Concerted Tech Based Entrepreneurship Effort Between Engineering And Business (2020)

Beginning in the fall of 1999 a team of faculty from engineering and from business at the University of Missouri-Columbia joined efforts to address the following question: How can we adapt and build upon the work of other universities to close some of the competency gaps for those students hired as engineers and managers engaged in manufacturing and innovation, given the existing needs and realities of our current and future manufacturing enterprises and the University of Missouri's educational and industrial environment? In addition, the team considered a secondary question: How can the educational process instill a more entrepreneurial attitude in our undergraduate students?
Rap2 regulates androgen sensitivity in human prostate cancer cells (2007)

We show that Rap2 is involved in androgen-mediated transcriptional and growth responses of human prostate cancer cells.
The Impact of Empagliflozin on Obstructive Sleep Apnea and Cardiovascular and Renal Outcomes: An Exploratory Analysis of the EMPA-REG OUTCOME Trial (2020)

In EMPA-REG OUTCOME, participants with OSA had greater comorbidity and higher frequency of CV and renal events. Empagliflozin had favorable effects on risk factors and CV and renal outcomes regardless of preexisting OSA and may also reduce the risk for new-onset OSA.
Separations of Residual Motion Errors Using a Stack of Interferometric Airborne SAR Images (2008)

Residual motion error estimation using the multisquint method is established as a robust technique to determine the track deviations beyond the accuracy of state of the art navigation systems in airborne SAR interferometry. But for stacks of interferograms the method can be problematic because only the differences between two tracks can be estimated, not the deviation of the track itself. This paper presents a method to overcome this problem, making airborne processing of interferometric image stacks as reliable as in the spaceborne case.
Evidence of REE Mobility and Fossil Ion Adsorbed REE Deposits in Pennsylvania (2021)

Presented at the 28th Rare Earth Research Conference (Ames, IA)
Hybrid method used to model via transitions (2010)

A hybrid approach to solve via impedance and model via transitions is presented in the paper. The method is a combination of via-plane capacitance extraction and the impedance matrices calculation of parallel plane pair. A new formulation of the integral equation method for axially symmetric geometry is used for the capacitance extraction. The method is validated with other model results.