gebhart/patrepeval huggingface dataset:
Time-frequency complexity and information (2002)

Many functions have been proposed for estimating signal information content and complexity on the time-frequency plane, including moment-based measures such as the time-bandwidth product and the Shannon and Renyi(see 4th Berkeley Symp. Math., Stat., Prob., vol.1) entropies. When applied to a time-frequency representation from Cohen's (1989) class, the Renyi entropy conforms closely to the visually based notion of complexity that we use when inspecting time-frequency images. A detailed discussion reveals many of the desirable properties of the Renyi information measure for both deterministic and random signals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
On Pattern for Popularization of Public Library in China (2007)

Drawing on the experiences home and abroad,Central library and branches may be an ideal pattern for popularization of public library in China,which can improve the development of basic level library.
Neuropsychological functioning in cocaine abusers with and without alcohol dependence (1999)

Thirty codependent cocaine and alcohol users were compared with age-, education-, race-, and sex-matched cocaine abusers (N = 30) and normals (N = 30) using an extended Halstead-Reitan Neuropsychological Test Battery to determine whether cocaine abusers with alcohol dependence were more cognitively impaired than singly addicted cocaine abusers. Tests were grouped and analyzed according to 8 major ability areas. Participants who abused both cocaine and alcohol did not differ from normals on the majority of test measures. An unexpected but consistent finding was the poorer performance of the cocaine sample relative to cocaine and alcohol abusers on measures of complex psychomotor and simple motor functioning (ps < .001). Pure cocaine abusers, but not abusers of both cocaine and alcohol, also performed more poorly than normals on a measure of global neuropsychological functioning (p < .01). These results are consistent with previous reports of generally mild cognitive dysfunction in cocaine abusers. The findings also suggest that cocaine and alcohol abusers of relatively young ages may be less cognitively impaired than demographically comparable cocaine abusers. Evidence from studies of vascular functioning in abusers of cocaine and alcohol alone and in combination is discussed as possible explanation for these findings.
Tissue Plasminogen Activator and Penetrating Keratoplasty (1990)

We report a patient who developed severe intraocular fibrin formation following penetrating keratoplasty and vitrectomy surgery. The fibrin response worsened despite aggressive treatment with topical steroids. On the second postoperative day, 25 micrograms of intracameral tissue plasminogen activator was administered, resulting in rapid resolution of the fibrin response. The graft remained clear. We believe tissue plasminogen activator may be useful in selected cases of severe, recalcitrant postkeratoplasy fibrin formation.
Promotion of human blastocyst formation by red cell hemolysate. (2002)

Recently, blastocyst transfer has been increasingly performed to improve the implantation rate achieved by in vitro fertilization and embryo transfer. This has created the need for new culture methods to improve in vitro blastulation. Culture with erythrocyte hemolysate promotes the development of early mouse embryos due to an antioxidant effect. The present study investigated whether erythrocyte hemolysate could also promote blastulation of human embryos. Eighty surplus embryos were obtained from 15 patients who gave informed consent. These embryos were cultured for 2 to 7 days after oocyte retrieval in medium with or without erythrocyte hemolysate. Blastocyst formation was observed in 53% and 28% of the embryos grown in hemolysate-supplemented and control cultures, respectively. The blastulation rate was significantly higher in hemolysate-supplemented culture than in control group (p = 0.02). These results suggest that culture medium supplemented with erythrocyte hemolysate may promote the blastulation of human embryos.
Chromosome 1p loss: A favorable prognostic factor in low‐grade gliomas (2005)

Abstract Search for loss of heterozygosity on chromosomes 1p, 9p, 10q, and 19q, epidermal growth factor receptor ( EGFR ) gene amplification, and p53 expression was performed in a series of 131 low‐grade gliomas. The profile of molecular changes, clinical findings, and histology were subsequently correlated with the course of the disease, mainly progression‐free survival. When these parameters were considered as candidate variables in a multivariate analysis, only loss of heterozygosity on chromosome 1p was associated with increased progression‐free survival (hazard ratio, 0.521), indicating a major favorable prognostic role of this genetic alteration in low‐grade gliomas. Ann Neurol 2005;58:322–326
Ultra-large-scale single-cell quantitative phase imaging (2018)

We demonstrate an interferometry-free, high-resolution and high-throughput quantitative-phase imaging platform, multi-ATOM, enabling ultra-large-scale single-cell image analysis (&gt;1,000,000 cells) in the context of label-free cancer cell screening in blood.
Migration of bisphenol A from can coatings—effects of damage, storage conditions and heating (2004)

Bisphenol A (BPA) is an important monomer used in the manufacture of epoxy resins for internal food can linings. Experiments were conducted to investigate the effects of different storage conditions and can damage on the migration of BPA to foods. These experiments were conducted in a systematic fashion by filling empty epoxyphenolic coated cans with four foods: soup, minced beef, evaporated milk and carrots and a food simulant (10% ethanol). Filled cans of each food type or simulant were then sealed and processed using appropriate conditions, before storage at three different temperatures: 5 degrees C, 20 degrees C and 40 degrees C. For each of the storage regimes, 50% of the cans were dented to establish if this would lead to increased BPA migration. Cans were removed from these stocks at intervals of 1, 3 and 9 months storage at 5 degrees C and 20 degrees C or 10 days, 1 and 3 months at 40 degrees C. Some initial problems of heterogeneity between samples was overcome by determining the amount of BPA in food as well as in the can lining. It was found that 80-100% of the total BPA present in the coating had migrated to foods directly after can processing by pilot plant filling with food or simulant, sealing and sterilization. This level was not changed by extended storage (up to 9 months) or can damage, indicating most migration was occurring during the can processing step. There was no noticeable difference, in this respect, between the different foods or the food simulant. Analysis of control samples (foods fortified with approximately 0.1 mg kg(-1) BPA and contained in Schott bottles) showed that BPA was stable under both processing and storage. Experiments were also conducted to investigate the potential effects, on the migration of BPA from can coatings, of cooking or heating foods in the can prior to consumption. Food cans were purchased and the food either cooked or heated in the can. BPA was analysed prior to and after the heating/cooking process. It was concluded from the results that there were no appreciable differences in the BPA level before and after cooking or heating.
The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection (2013)

Vaccination with the pre-erythrocytic malaria vaccine RTS,S induces high levels of antibodies and CD4(+) T cells specific for the circumsporozoite protein (CSP). Using a biologically-motivated mathematical model of sporozoite infection fitted to data from malaria-naive adults vaccinated with RTS,S and subjected to experimental P. falciparum challenge, we characterised the relationship between antibodies, CD4(+) T cell responses and protection from infection. Both anti-CSP antibody titres and CSP-specific CD4(+) T cells were identified as immunological surrogates of protection, with RTS,S induced anti-CSP antibodies estimated to prevent 32% (95% confidence interval (CI) 24%-41%) of infections. The addition of RTS,S-induced CSP-specific CD4(+) T cells was estimated to increase vaccine efficacy against infection to 40% (95% CI, 34%-48%). This protective efficacy is estimated to result from a 96.1% (95% CI, 93.4%-97.8%) reduction in the liver-to-blood parasite inoculum, indicating that in volunteers who developed P. falciparum infection, a small number of parasites (often the progeny of a single surviving sporozoite) are responsible for breakthrough blood-stage infections.
Supplementary Data from Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer (2023)

Supplementary Data from Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer
The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection (2009)

We present data that suggest HPV16 infection is in part mediated by cysteine proteases, and that NH4Cl blocks the intracellular trafficking of infectious viral particles. To our knowledge this is the first demonstration that cysteine proteases influence the infection of a non-enveloped virus.
Pseudo-exhaustive testing of sequential circuits (2003)

A new sequential circuit partitioning algorithm is introduced which enhances pseudo-exhaustive testing. Our PIFAN algorithm is based on an analysis of Primary Input cones and FANout values. Results are presented which show that PIFAN offers significant reductions in hardware overhead and test time when compared to alternative partitioning algorithms.
Plasma Semicarbazide-Sensitive Amine Oxidase in Stroke (1999)

Semicarbazide-sensitive amine oxidase (SSAO) has been suggested to be involved in the development of vascular endothelial damage. The source of the soluble form of SSAO found in the blood serum is unknown. However, it has been speculated that it is secreted from cells within the vascular wall where high activity of the enzyme is found. Altered SSAO activity has been reported in atherosclerotic plaques of the human aorta. Stroke is a manifestation of long-term atherosclerotic disease, and in this study, plasma SSAO activities were estimated in 42 patients with cerebral thrombosis and 26 patients with cerebral embolism, and compared to two control groups of 45 individuals in total. No statistically significant differences were found between the patient groups and controls regarding plasma SSAO activity, suggesting that changes in the soluble form of SSAO found in the circulation do not play a major role in this type of acute cerebrovascular event. Furthermore, it does not seem likely that the involvement of vascular tissue occurring in stroke results in release of the enzyme into the circulation. Nevertheless, further studies on tissue-bound SSAO in cerebral vessels would be of great interest.
A retrospective study of 157 hospitalized cats with pancreatitis in a tertiary care center: Clinical, imaging and laboratory findings, potential prognostic markers and outcome (2018)

Previously unreported, clinically relevant, potential prognostic factors, including hypoglycemia, azotemia, parenteral nutrition, and withholding antibacterial treatment were identified in this exploratory study. These preliminary results should be examined further in confirmatory studies.
Performance Analysis of Large Multiuser MIMO Systems With Space-Constrained 2-D Antenna Arrays (2016)

Massive multiple-input-multiple-output (MIMO) systems deploying a large number of antennas at the base station (BS) have been shown to produce high spectral and energy efficiency (EE) under the assumptions of increasing BS physical space and critical antenna spacing. We examine the deployment of massive MIMO systems and resulting EE with a more realistic scenario considering a 2-D rectangular array with increasing antenna elements within a fixed physical space. Mutual coupling and correlation among the BS antennas are incorporated by deriving a practical mutual coupling matrix which considers coupling among all antenna elements within a BS. We also provide a realistic analysis of the energy consumption using a model, which takes into account the circuit power consumptions as a function of the number of BS antennas and then present a performance analysis of two practical low complexity detectors/receivers keeping EE into consideration. The simulation results obtained show that EE does not monotonically increase with the number of BS antennas. On the contrary, it is a decreasing concave or quasi-concave function of the number of BS antennas depending on the detection technique used at the receiver. We also show that with decreasing spacing between the antennas, mutual coupling increases, contributing toward reduction in EE. Our analysis thus shows that EE does not increase infinitely in a massive MIMO system when the increasing number of antennas are to be accommodated within a fixed physical space and the total power consumed is considered to be a function of the antennas. Accordingly, closed-form expressions for the optimum number of antennas to attain maximum EE for zero forcing (ZF) are obtained.
Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs (2015)

Clinical disease associated with porcine epidemic diarrhea virus (PEDV) infection in naïve pigs is well chronicled; however, information on endemic PEDV infection is limited. To characterize chronic PEDV infection, the duration of infectious virus shedding and development of protective immunity was determined. On Day 0 (D0), a growing pig was challenged with PEDV and 13 contacts were commingled. On D7, 9 contact pigs (principal virus group (PG)), were selected, moved to a separate room and commingled with one sentinel pig (S1). This process was repeated weekly with S2, S3 and S4. The PG was PEDV-positive by PCR from D3-11, with some pigs intermittently positive to D42. Pigs S1 and S2 were PEDV-positive within 24 hours of commingling. Antibodies were detected in all PG by D21 and by 7 days post-contact in S1 and S2. Pigs S3 and S4 were PCR and antibody negative following commingling. To evaluate protective immunity, 5 naïve pigs (N) and the PG were challenged (N/C, PG/C) with homologous virus on D49. All N/C pigs were PEDV PCR-positive by D52 with detection out to D62 in 3/5 N/C pigs. All PG/C pigs were PEDV PCR-negative post-challenge. By D63, all N/C seroconverted. Although PEDV RNA was demonstrated in pigs after primary infection until D42, infectious PEDV capable of horizontal transmission to naïve pigs was only shed 14-16 days after infection to age-matched pigs. Homologous re-challenge 49 days post initial PEDV exposure did not result in re-infection of the pigs. This demonstrates potential for an effective PEDV vaccine.
Development and aging of cell topography in the human retinal pigment epithelium. (1997)

With no marked change in total cell number, peripheral RPE in humans enlarges in area throughout life, but the RPE in more central regions decreases in area.
The Anti‐inflammatory Activiy of Metal Complexes of Heterocyclic Thiosemicarbazones, 2-Substituted Pyridine N-Oxides and 2-Pyridylthioureas (1996)

The thiosemicarbazones and their related metal complexes were shown to be potent anti-inflammatory agents in rodents at 8 mg kg−1. They were effective in blocking induced edema and endotoxic shock while blocking both local and central pain processes. The ability of the agents to function as anti-inflammatory agents is multifold. First, Tumor Necrosis Factor-alpha (TNFα) and Interleukin-1 (IL-1) release was markedly reduced by the agents. Second, high-affinity receptor binding on fibroblasts of TNFα and IL-1 was significantly inhibited. Third, cellular events, e.g. lysosomal enzymes of specific cells, such as macrophages, were inhibited and prostaglandin cyclo-oxygenase and leukotriene 5′-lipoxygenase enzymic synthetic rates were significantly reduced, which should cause an overall reduction of the inflammatory process.
3D Free-viewpoint video capturing interface by using bimanual operation (2010)

This paper proposes an interface for capturing the 3D free-viewpoint video of a soccer game by using bimanual operation. Users virtually capture 3D free-viewpoint video by observing a virtualized miniature soccer stadium on a tabletop. To exploit the human hand's dexterous manipulation ability, we use a 3D tracker to input the 3D position and the orientation of a virtual camera that captures the 3D free-viewpoint video. The proposed system displays the overhead-view on a tabletop where a user manipulates the virtual camera. By browsing this overhead-view, the context can be easily understood (e.g., positions of players and the ball) in a virtualized soccer scene. We develop a proposed system and conduct on evaluations to confirm the effectiveness of our proposed method.
Elastic Control for Navigation Tasks on Pen-based Handheld Computers (2008)

Isotonic pen and finger interfaces for handheld devices are very suitable for many interaction tasks (eg. pointing, drawing). However, they are not appropriate for rate controlled techniques, as required for other tasks such as navigation in 3D environments. In this paper, we investigate the influence of elastic feedback to enhance user performance in rate controlled interaction tasks. We conducted an experiment, which proves evidence that elastic feedback, given to input movements with the pen, provides better control for 3D travel tasks. Based on these findings, we designed several prototypes that illustrate the ease of applying various elastic control conditions to contemporary handheld computers with finger- or pen-based input capabilities.
Variation in susceptibility and tolerance within and between populations of Tussilago farfara L. infected by Coleosporium tussilaginis (Pers.) Berk. (1995)

Quantitative variation in susceptibility to infection by the rust Coleosporium tussilaginis, and in reduction in growth owing to the infection, were determined in 30 clonally propagated genotypes of Tussilago farfara sampled from three geographically isolated sites, Arnhem (The Netherlands), Lancaster and Sheffield (both UK). Populations, and genotypes within populations showed no significant variation in intensity of disease after artificial inoculation under ideal conditions with a fungal isolate collected from the Lancaster population. By contrast, significant differences between and within populations were observed after natural secondary infection by spores produced from the artificially inoculated plants. Genotypes differed considerably in the reduction in growth caused by the infection, but this was not correlated with the extent of symptoms shown by the plants. Low resistance was associated with high tolerance, as in the Lancaster and Sheffield populations, while high resistance was associated with low tolerance, as in the Arnhem population. The evolutionary significance of these associations is discussed.
An exploratory randomized controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI) (2020)

Abstract Background Antiviral therapies against the novel coronavirus SARS-CoV-2, which has caused a global pandemic of respiratory illness called COVID-19, are still lacking. Methods Our study ( NCT04252885 , named ELACOI), was an exploratory randomized (2:2:1) controlled trial assessing the efficacy and safety of lopinavir/ritonavir (LPV/r) or arbidol monotherapy for treating patients with mild/moderate COVID-19. Findings This study successfully enrolled 86 patients with mild/moderate COVID-19 with 34 randomly assigned to receive LPV/r, 35 to arbidol and 17 with no antiviral medication as control. Baseline characteristics of the three groups were comparable. The primary endpoints, the average time of positive-to-negative conversion of SARS-CoV-2 nucleic acid and conversion rates at days 7 and 14, were similar between groups (all P &gt;0.05). There were no differences between groups in the secondary endpoints, the rates of antipyresis, cough alleviation, or improvement of chest CT at days 7 or 14 (all P &gt;0.05). At day 7, eight (23.5%) patients in the LPV/r group, 3 (8.6%) in the arbidol group and 2(11.8%) in the control group showed a deterioration in clinical status from moderate to severe/critical( P =0.206). Overall, 12 (35.3%) patients in the LPV/r group and 5 (14.3%) in the arbidol group experienced adverse events during the follow-up period. No apparent adverse event occurred in the control group. Conclusions LPV/r or arbidol monotherapy present little benefit for improving the clinical outcome of patients hospitalized with mild/moderate COVID-19 over supportive care. Funding This study was supported by project 2018ZX10302103-002, 2017ZX10202102-003-004 and Infectious Disease Specialty of Guangzhou High-level Clinical Key Specialty (2019-2021).
Chiropractic Students and Research: Assessing the Research Culture at a North American Chiropractic College (2010)

This study expresses possibilities for building a strong research culture at the college. Students were aware of the necessity for research and were openly interested in conducting research. Modification of current academic policies will allow for greater student research opportunities and the development of tomorrow's researchers.
Draft Genome Sequence of Bifidobacterium animalis subsp. lactis Strain CECT 8145, Able To Improve Metabolic Syndrome In Vivo (2014)

Bifidobacterium animalis subsp. lactis strain CECT 8145 is able to reduce body fat content and improve metabolic syndrome biomarkers. Here, we report the draft genome sequence of this strain, which may provide insights into its safety status and functional role.
<i>The Free Review</i>: opkomst en ondergang van een vrijdenkerstijdschrift (2003)

In dit artikel staat &lt;em&gt;The Free Review&lt;/em&gt; centraal, een vrijdenkerstijdschrift dat in 1893 werd opgericht met de simpele maar ambitieuze doelstelling om met de pen de sociale, religieuze en culturele orde van het Engeland van de late negentiende eeuw grondig overhoop te halen. Het tijdschrift is uiteindelijk minder dan acht jaar verschenen, en heeft zich tot nu toe nauwelijks in de belangstelling van onderzoekers mogen verheugen.
Anisotropic elastic limits and phase transitions of rutile phase TiO2 under shock compression (1983)

Anisotropic elastic limits and phase transitions of the rutile phase TiO2 under shock compression are studied, on the basis of the measurements of particle-velocity histories and free-surface motions along the [100], [110], and [001] axis directions in the stress range up to 38.6 GPa. The stresses of Hugoniot elastic limit (HEL) along the [100] and [001] axis directions are determined to be 7.8±0.5 and 4.1±0.3 GPa, respectively. These different HEL stresses are reasonably analyzed by an inherent yield stress of 3.0±0.3 GPa. A Hugoniot kink at 12.2±0.6 or 17.0±0.7 GPa along the [100] or [110] axis direction, respectively, and two kinks at 10.6±0.5 and 33.7±1.3 GPa along the [001] axis direction are observed. Considering the volume changes and the recovery experiments of α-PbO2 phase, two former ones and the last one are suggested to correspond to the beginning of phase transitions to a α-PbO2 phase and a hexagonal phase, respectively. These anisotropic behaviors clearly show the typical evidences of the uniaxial strain effects of shock wave metamorphism of crystals.