gebhart/patrepeval huggingface dataset:
A Channel Quality-aware Scheduling and Resource Allocation Strategy for Downlink LTE Systems (2012)

Today, the main purpose of a scheduler for Long Term Evolution (LTE) is to provide the best system performance. However, it may decrease the system performance to have latency and starvation of lower priority connections in a resource allocation phase. There has been little research performed on LTE downlink scheduling and resource allocation. This paper proposes an efficient algorithm that includes scheduling strategies and resource allocation mechanisms, to avoid the latency or starvation of lower priority connections and to maintain system performance in downlinks of LTE. The algorithm discusses five levels of bandwidth request situations to assign priority and to allocate the bandwidth for each connection. Therefore, we design an LTE downlink scheduling scheme and a resource allocation strategy that not only aims to achieve the system’s highest performance but also avoids latency and starvation problems. As shown in the results of simulations, the proposed algorithm can provide proportional fairness and high system performance in downlinks of LTE systems.
Data from A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Novel targeted therapeutics have transformed the care of subsets of patients with cancer. In pediatric malignancies, however, with simple tumor genomes and infrequent targetable mutations, there have been few new FDA-approved targeted drugs. The cyclin-dependent kinase (CDK)4/6 pathway recently emerged as a dependency in Ewing sarcoma. Given the heightened efficacy of this class with targeted drug combinations in other cancers, as well as the propensity of resistance to emerge with single agents, we aimed to identify genes mediating resistance to CDK4/6 inhibitors and biologically relevant combinations for use with CDK4/6 inhibitors in Ewing.&lt;/p&gt;Experimental Design:&lt;p&gt;We performed a genome-scale open reading frame (ORF) screen in 2 Ewing cell lines sensitive to CDK4/6 inhibitors to identify genes conferring resistance. Concurrently, we established resistance to a CDK4/6 inhibitor in a Ewing cell line.&lt;/p&gt;Results:&lt;p&gt;The ORF screen revealed &lt;i&gt;IGF1R&lt;/i&gt; as a gene whose overexpression promoted drug escape. We also found elevated levels of phospho-IGF1R in our resistant Ewing cell line, supporting the relevance of IGF1R signaling to acquired resistance. In a small-molecule screen, an IGF1R inhibitor scored as synergistic with CDK4/6 inhibitor treatment. The combination of CDK4/6 inhibitors and IGF1R inhibitors was synergistic &lt;i&gt;in vitro&lt;/i&gt; and active in mouse models. Mechanistically, this combination more profoundly repressed cell cycle and PI3K/mTOR signaling than either single drug perturbation.&lt;/p&gt;Conclusions:&lt;p&gt;Taken together, these results suggest that IGF1R inhibitors activation is an escape mechanism to CDK4/6 inhibitors in Ewing sarcoma and that dual targeting of CDK4/6 inhibitors and IGF1R inhibitors provides a candidate synergistic combination for clinical application in this disease.&lt;/p&gt;&lt;/div&gt;
Full‐color organic EL display (1998)

Abstract— For the first time, we report a full‐color organic display with 10‐in. diagonal and high resolution (VGA). This display was based on blue organic EL with color‐changing mediums (CCM). A blue‐emitting material with heat resistance was developed and used. In the construction of the full‐color display, we used a tapered In 2 O 3 ‐ZnO with Al auxiliary electrodes as an anode with a low resistivity of 2 Ω/□. In addition, the CCM structure was improved in order to increase the contrast ratio of the display.
Optical bistability in semiconductor periodic structures (1991)

A theoretical demonstration of optical bistability in periodic layered media, particularly in long-period GaAs/AlAs superlattices is presented. The proposed structure consists of a periodic multilayer system, as opposed to previously demonstrated nonlinear bistable devices which employed Fabry-Perot etalons. The optical resonance effect which is essential for bistable devices is, in this case, induced by a refractive index modulation. The nonlinear active medium is distributed in the whole structure rather than placed between the two mirrors of a Fabry-Perot cavity. It is shown by a complete calculation of wave propagation in the periodic nonlinear medium that a multiple valued feature appears in the structure's nonlinear reflectivity spectrum. The input/output characteristics of the structure exhibit bistable hysteresis similar to that of a nonlinear Fabry-Perot etalon.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cholinergic Modulation of Disorder-Relevant Neural Circuits in Generalized Anxiety Disorder (2020)

These results demonstrate for the first time that the function of disorder-relevant neural circuits in generalized anxiety disorder can be beneficially altered through modulation of cholinergic neurotransmission and suggest potential for this system as a novel target for anxiolytic pharmacotherapy.
Precoded Physical Layer Network Coding with Coded Modulation in MIMO-OFDM Bi-Directional Wireless Relay Systems (2020)

This paper proposes coded modulation for physical layer network coding in multiple input multiple output orthogonal frequency division multiplexing (MIMO-OFDM) bi-directional wireless relay systems where precoding is applied. The proposed coded modulation enables the relays to decode the received signals, which improves the transmission performance. Soft input decoding for the proposed coded modulation is proposed. Furthermore, we propose two precoder weight optimization techniques, called “per subcarrier weight optimization” and “total weight optimization”. This paper shows a precoder configuration based on the optimization with the lattice reduction or the sorted QR-decomposition. The performance of the proposed network coding is evaluated by computer simulation in a MIMO-OFDM two-hop wireless relay system with the 16 quadrature amplitude modulation (QAM) or the 256QAM. The proposed coded modulation attains a coding gain of about 2dB at the BER of 10-4. The total weight optimization achieves about 1dB better BER performance than the other at the BER of 10-4.
Multi-scale UNet with Self-Constructing Graph Latent for Deformable Image Registration (2023)

Deep Learning based deformable registration techniques such as Voxelmorph, ICNet, FIRE, do not explicitly encode global dependencies and track large deformations. This research attempts to encode semantics, i.e. structure and overall view of the anatomy in the supplied image, by incorporating self-constructing graph network in the latent space of a UNet model. It also attempts to track larger deformations through multiscale architecture and maintains consistent deformations through cycle consistency. The proposed method was compared against Voxelmorph and ANTs for T1 intramodal and T1-T2 Intermodal registration on IXI Dataset. The experiments show that the proposed model outperforms the baselines.
Designing Ambient and Personalised Displays to Encourage Healthier Lifestyles (2012)

In recent years, the deteriorations of living habits like immobilization or unhealthy diet are becoming serious social problems in many developed countries. Even if we know the importance, it is difficult to change our undesirable habits and to maintain a desirable lifestyle. Previous studies have suggested that persuasive technology can play a significant role in persuading individuals for behavioural change. In the article, we discuss the design of persuasive ambient displays aimed at addressing this issue borrowing theories from behavioural psychology. In our design, aesthetic and empathetic expressions are used to represent the visualisation reflecting behavioural feedback of an individual. If an individual's behaviour is leaned towards healthier lifestyle, the display expression is designed to boost his/her positive emotion where as display expression is progressively shifted to increase negative emotion of the individual if he/she does not sustain the desirable behaviour. In this paper, we introduce design principles of our approach and present four case studies to show the applicability of our approach. We also discuss a number of issues uncovered during the design and evaluation of these case studies.
False color signal reduction method for single chip color video cameras (1994)

Video devices such as VCRs have been increasingly digitalized and it is necessary to improve the picture quality of cameras to cope with digitalized video devices. For the single-chip color video cameras with a line sequential color difference signals system, which are primarily used at present as the camera units for home-use and ITV (industrial television), the authors have studied a luminance signal generation method for low attenuation of high-frequency components using the correlation of the ratio between the chrominance signal and the luminance signal in localized image areas. Using a luminance signal with low attenuation of the high-frequency components, the writers have studied a method of reducing the false color signal generated in single-chip color video cameras through the application of image simulation, and have obtained a favorable result as reported in the present paper.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Method and apparatus for determining two-phase flow in rock fracture (1992)

An improved method and apparatus as disclosed for measuring the permeability of multiple phases through a rock fracture. The improvement in the method comprises delivering the respective phases through manifolds to uniformly deliver and collect the respective phases to and from opposite edges of the rock fracture in a distributed manner across the edge of the fracture. The improved apparatus comprises first and second manifolds comprising bores extending within porous blocks parallel to the rock fracture for distributing and collecting the wetting phase to and from surfaces of the porous blocks, which respectively face the opposite edges of the rock fracture. The improved apparatus further comprises other manifolds in the form of plenums located adjacent the respective porous blocks for uniform delivery of the non-wetting phase to parallel grooves disposed on the respective surfaces of the porous blocks facing the opposite edges of the rock fracture and generally perpendicular to the rock fracture.
Tracer studies on the metabolism of the Gardner lymphosarcoma. II. Energy-yielding reactions and amino acid uptake into protein of the tumor cell. (1951)

Summary It has been shown that the incorporation of four amino acids into the protein of the Gardner lymphosarcoma cells is markedly stimulated by the presence of glucose. Glycolytic inhibitors strongly suppressed the amino acid uptake. The presence of succinate stimulated the respiration of the tumor cells, and, concomitant with this, a marked increase in the uptake of glycine and leucine and a slight increase in phenylalanine uptake into the cell protein were observed. Tricarboxylic acid cycle inhibitors suppressed oxidations and amino acid uptake. Acetate-1-C14 was partly oxidized to CO2 by the tumor cells and normal spleen cells. Some of the C14 from the acetate was found in the cell proteins. These processes and respiration were inhibited by fluoroacetate. Citrate was formed from acetate and oxalacetate by the tumor and normal spleen cells. Alanine-1-C14, glycine-1-C14, and leucine-2-C14 were also partly oxidized to CO2 by the tumor cells. The implications of these results are discussed.
Nucleotides. IV.1 Conversion of Ribonucleosides to New 2',3'-Ketal Derivatives2 (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleotides. IV.1 Conversion of Ribonucleosides to New 2',3'-Ketal Derivatives2Alexander Hampton, J. C. Fratantoni, P. M. Carroll, and Su-chu WangCite this: J. Am. Chem. Soc. 1965, 87, 23, 5481–5487Publication Date (Print):December 1, 1965Publication History Published online1 May 2002Published inissue 1 December 1965https://pubs.acs.org/doi/10.1021/ja00951a042https://doi.org/10.1021/ja00951a042research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multispectral imaging for medical diagnosis (1977)

Photography technique determines amount of morbidity present in tissue. Imaging apparatus incorporates numerical filtering. Overall system operates in near-real time. Information gained from this system enables physician to understand extent of injury and leads to accelerated treatment.
Dual Effect of Dihydroergotamine and Dihydroergotoxin in Isolated Human Femoral Veins and Arteries (1982)

In human femoral vein strips, dihydroergotamine and dihydroergotoxin caused a slowly proceeding, long-lasting increase in tone. Dihydroergotamine had markedly higher affinity than noradrenaline, it possessed nearly the same intrinsic activity as noradrenaline. Dihydroergotoxin was less effective than dihydroergotamine. In isolated femoral artery strips, dihydroergotamine showed lower affinity and lower intrinsic activity in terms of noradrenaline. Dihydroergotoxin had negligible vasoconstrictor effects in arteries. In veins, dihydroergotoxin had a stronger alpha-adrenolytic effect than in arteries. In isolated arteries, dihydroergotoxin was equieffective to dihydroergotamine whose alpha-adrenoceptor blocking effect did not significantly differ in veins and arteries. Our results show that dihydroergotamine at very low concentrations exerted predominantly venoconstrictor effects and, therefore, it is more suited to increase the venous tone than dihydroergotoxin which at low concentrations showed alpha-adrenoceptor blocking activity.
[Clinical usefulness of the Doppler-echocardiographic method for evaluating intracardiac shunts. Combined Doppler and hemodynamic study]. (1989)

The purpose of this study was to assess the accuracy of a quantitative two-dimensional Doppler echocardiographic method for estimating systemic and pulmonary blood flows in atrial and ventricular septal defects. Twenty-eight patients (mean age 22 +/- 14), with atrial septal defect (ADS) or ventricular septal defect (VSD) underwent Doppler-echocardiography and cardiac catheterization in order to assess pulmonary blood flow (QP), systemic blood flow (QS), the left to right shunt (SH) and the ratio of pulmonary to systemic flow (QP/QS ratio). Cardiac output was also determined by the oximetry method according to Fick principle. Pulmonary output assessed by Doppler was 7.9 +/- 0.61/min, by catheterization 9.0 +/- 3.9. Linear regression analysis showed a low correlation coefficient (r = 0.10; p = NS). Systemic output evaluated by Doppler resulted 4.6 +/- 1.4 l/m, while at catheterization 5.1 +/- 1.5 l/min (r = 0.25; p = NS). Doppler evaluation of left-to right shunt was 3.3 +/- 1.5 l/min, at catheterization 3.9 +/- 3.1 (r = 0.74; p less than 0.001). Doppler QP/QS ratio resulted 1.7 +/- 0.5, at catheterization 1.8 +/- 0.5 (r = 0.96; p less than 0.0010. The results showed that, in spite of the lack of correlation between the pulmonary and systemic outputs assessed by Doppler vs catheterization, QP/QS ratio, as well as SH, are useful noninvasive indexes in order to evaluate intracardiac shunts.
Succinylated Octopamine Ascarosides and a New Pathway of Biogenic Amine Metabolism in Caenorhabditis elegans (2013)

The ascarosides, small-molecule signals derived from combinatorial assembly of primary metabolism-derived building blocks, play a central role in Caenorhabditis elegans biology and regulate many aspects of development and behavior in this model organism as well as in other nematodes. Using HPLC-MS/MS-based targeted metabolomics, we identified novel ascarosides incorporating a side chain derived from succinylation of the neurotransmitter octopamine. These compounds, named osas#2, osas#9, and osas#10, are produced predominantly by L1 larvae, where they serve as part of a dispersal signal, whereas these ascarosides are largely absent from the metabolomes of other life stages. Investigating the biogenesis of these octopamine-derived ascarosides, we found that succinylation represents a previously unrecognized pathway of biogenic amine metabolism. At physiological concentrations, the neurotransmitters serotonin, dopamine, and octopamine are converted to a large extent into the corresponding succinates, in addition to the previously described acetates. Chemically, bimodal deactivation of biogenic amines via acetylation and succinylation parallels posttranslational modification of proteins via acetylation and succinylation of L-lysine. Our results reveal a small-molecule connection between neurotransmitter signaling and interorganismal regulation of behavior and suggest that ascaroside biosynthesis is based in part on co-option of degradative biochemical pathways.
The mechanisms used by enteropathogenicEscherichia colito control filopodia dynamics (2008)

Enteropathogenic Escherichia coli (EPEC) subverts actin dynamics in eukaryotic cells by injecting effector proteins via a type III secretion system. First, WxxxE effector Map triggers transient formation of filopodia. Then, following recovery from the filopodial signals, EPEC triggers robust actin polymerization via a signalling complex comprising Tir and the adaptor proteins Nck. In this paper we show that Map triggers filopodia formation by activating Cdc42; expression of dominant-negative Cdc42 or knock-down of Cdc42 by siRNA impaired filopodia formation. In addition, Map binds PDZ1 of NHERF1. We show that Map-NHERF1 interaction is needed for filopodia stabilization in a process involving ezrin and the RhoA/ROCK cascade; expression of dominant-negative ezrin and RhoA or siRNA knock-down of RhoA lead to rapid elimination of filopodia. Moreover, we show that formation of the Tir-Nck signalling complex leads to filopodia withdrawal. Recovery from the filopodial signals requires phosphorylation of a Tir tyrosine (Y474) residue and actin polymerization pathway as both infection of cells with EPEC expressing TirY474S or infection of Nck knockout cells with wild-type EPEC resulted in persistence of filopodia. These results show that EPEC effectors modulate actin dynamics by temporal subverting the Rho GTPases and other actin polymerization pathways for the benefit of the adherent pathogen.
Phenotypic Drug Discovery: History, Evolution, Future (2020)

Historically, empirical observations of phenotypic changes have played a pivotal role in the discovery of new medicines. Scientists and organizations that endeavor to discover new medicines employ all available knowledge and expertise to identify the best starting points and strategies. Unfortunately, knowledge gaps exist between the understanding of disease and the identification of useful therapeutics. History shows a progression in utilizing new knowledge to reduce the uncertainty and reliance on serendipity: from Ehrlich's ideas of ‘chemotherapy’ and ‘magic bullets’, to Black and Janssen's desire to start with ‘pharmacologically active compounds’, to Hitchings and Elion's strategy to utilize ‘new biochemical understandings’, and most recently, the use of genetics and genomics to identify drug targets. Throughout this evolution of knowledge and strategies, trial-and-error empiricism was required to bridge the translational knowledge gap in order to identify first-in-class compounds. Recently, the reliance upon empiricism was formalized as phenotypic drug discovery (PDD). At the core of PDD is an unbiased selection of drug candidates without prior assumptions as to how the candidate will work. PDD is evolving to a more formalized strategy to help address the uncertainty and risk associated with using empiricism to bridge mechanistic knowledge gaps.
A compact ring delay line for high speed synchronous DRAM (2002)

We proposed a compact delay line scheme, ring delay line (RDL). It has a ring topology instead of linear one. The ring time-to-digital converter (TDC) works with wide range of operating frequencies with the help of a shift register. Since the silicon area of ring TDC is negligible, RDL consumes about half of the other linear delay line's area. Its locking time is found to be 2 clock cycles and operating current is less than 1 mA.
Virulence of Bordetella bronchiseptica: role of adenylate cyclase-hemolysin (1993)

Bordetella bronchiseptica is a pathogen of laboratory, domestic, and wild animals and sometimes of humans. In the present study some characteristics of the virulence of B. bronchiseptica isolates of different origin were studied. All isolates had similar phenotypes, similar bacteriological characters, and synthesized adenylate cyclase-hemolysin, filamentous hemagglutinin and pertactin but not pertussis toxin. These isolates, however, differed in their ability to express dermonecrotic toxin and to cause a lethal infection, but no correlation was found with the human or animal origin of the isolates. The fact that the most virulent isolate did not express dermonecrotic toxin suggests that this toxin does not play an important role in the virulence of the bacteria in the murine model. After infection with virulent B. bronchiseptica a very early synthesis and a persistence of anti-adenylate cyclase-hemolysin and anti-filamentous hemagglutinin antibodies were observed in the sera of infected mice, suggesting a persistence of the bacteria or of its antigens. B. bronchiseptica adenylate cyclase-hemolysin was purified and was shown to be a major protective antigen against B. bronchiseptica infection. Furthermore, we showed that its immunological and protective properties were different from that of B. pertussis adenylate cyclase-hemolysin, confirming that Bordetella species are immunologically different.
Nefer, Sinuhe and clinical research assessing post COVID-19 condition (2020)

In the immortal classical novel by Finnish writer Mika Waltari (1908–1979) (figure 1), Nefer, a beautiful and cunning Egyptian courtesan, seduces and befools Sinuhe, the pharaoh's physician. Sinuhe is bewitched by her charms and sacrifices everything for her – even his parents’ house and grave – only to be cruelly rejected when Nefer tires of playing with him. Clinical research studies reporting on post COVID-19 condition should follow some basic recommendations <http://bit.ly/3h4OEIa> J.B. Soriano is Senior Consultant at the COVID-19 Clinical Management Team, WHO Health Emergency Programme, World Health Organization HQ, Geneva, Switzerland.