gebhart/patrepeval huggingface dataset:
The effects of nutritional level and body condition score on cytokines in seminal plasma of beef bulls (2023)

Introduction High quality semen is essential for reproductive efficiency. Nutrition and environmental factors impact the ejaculate components, like cytokines, that are essential for pregnancy establishment. We hypothesized that differing nutritional periods and body condition scores would affect seminal plasma cytokine concentrations of bulls. Methods Mature Angus bulls (n=11) were individually housed and randomly assigned to either over-fed (n=5) or restricted (n=6) treatment pathways. Bulls were fed different volumes of a single ration creating 8 individual treatment periods. Body weight and body condition scores were taken every 14 d to manage intake volumes. Ejaculates were collected every 84 d to determine seminal plasma cytokine profiles. A complete randomized design was used to evaluate seminal plasma cytokines after each nutritional treatment. Initial cytokine concentrations and volume of the ejaculate were included as covariates. Results All cytokines returned to initial concentrations following maintenance treatments at an ideal body condition score of 6. Nutritional treatments affected ( P ≤ 0.05) IFN-γ, IL-8, MIP-1α, MIP-1β, TNF-α, IL-1β, and VEGF-A. However, TNF-α, IFN-γ, and MIP-1α had the greatest impact on cytokine profile. Discussion Nutritional levels and adiposity altered seminal plasma cytokine concentrations which could potentially impact the inflammatory balance of the uterus and the immune responses necessary for pregnancy establishment.
Gamma energy evaluation for creation of 111mCd, 113mIn, and 115mIn isotopes (2019)

NASA Glenn Research Center is investigating nuclear reactions in deuterated materials exposed to bremsstrahlung photons with kinetic energies from 1-3 MeV. Recent experiments used a continuous beam Dynamitron electron&#13;\naccelerator with a braking target. Electron beam energy loss verification was desired and experiments using cadmium and indium were completed which are known to transition to excited metastable states after exposure to bremsstrahlung photons. The gamma spin-up of 111Cd, 113In, and 115In are with photon beam energies of 1017 keV, 1024 keV, and 941 keV respectively. Recent tests corroborated published&#13;\ngamma energies using a beam energy loss of 62 to 74 keV.
Accurate thigh inter-muscular adipose quantification using a data-driven and sparsity-constrained deformable model (2015)

The thigh inter-muscular adipose tissue (IMAT) quantification plays a critical role in various medical analysis tasks, e.g., the analysis of physical performance or the diagnose of knee osteoarthritis. In recent years, several techniques have been proposed to perform automated thigh tissues quantification. However, nobody has provided effective methods to track fascia lata, which is an important anatomic trail to distinguish between subcutaneous adipose tissue (SAT) and I-MAT in thigh. As a result, the estimation of IMAT may not be accurate for subjects with pathological conditions. On the other hand, tissue prior information, e.g., intensity, orientation and scale, becomes critical to infer and refine the fascia lata boundary from image appearance cues. In this paper, we propose a novel data-driven and sparsity-constrained de-formable model to obtain accurate fascia lata labeling. The model deformation is driven by the target points on fascia lata detected by a local discriminative classifier in a narrowband fashion. By using a sparsity-constrained optimization, the deformation is solved with errors and outliers suppression. The proposed approach has been evaluated on a set of 3D MR thigh volumes. In a comparison with another state-of-art framework, our approach produces superior performance.
Phase Equilibria in Lithium-Chalcogen Systems (1972)

The equilibrium phase diagram of the lithium‐sulfur system has been investigated. A miscibility gap extends from 0.2 to 37.0 atom per cent (a/o) lithium above a monotectic temperature of 364.8°C; the critical temperature is greater than 600°C. The only intermediate phase found is , which melts at 1372°C.
Real-time polymerase chain reaction for rapid detection of genes encoding SHV extended-spectrum β-lactamases (2010)

This method represents a powerful tool for epidemiological studies of SHV ESBLs. Furthermore, it has potential for use in diagnostic microbiology.
A Novel Semi-Active Suspension System for Automobiles Using Jerk-Driven Damper (JDD) (2011)

With the new advancements in the vibration control, the control strategies for the controllable&#13;\nsemi-active dampers are finding their way as an essential part of vibration isolators,&#13;\nparticularly in vehicle suspension systems. An analysis of frequency response for single degree&#13;\nof freedom (1DOF) system gives an attribute to the fact that in a semi-active suspension&#13;\nsystem, the damping coefficients can be adjusted to improve ride comfort and road handling&#13;\nperformances.&#13;\nThe systems study includes various type of semi-active suspension systems, employing&#13;\nnonlinear magnetorheological(MR) dampers that are controlled to provide improved vibration&#13;\nisolation. The currently available control strategies for semi-active dampers can be&#13;\ndivided into two main groups. The first one is `On-Off' control and second one is `continuous'&#13;\ncontrol of variable dampers. Available control strategies are either proportional to the&#13;\nrelative velocity of sprung mass or the acceleration of sprung mass. A new control strategy&#13;\nwhich is proportional to the jerk produced in sprung mass called Jerk Driven Damper (JDD)&#13;\nis proposed and analyzed by the use of two state 'On-Off' damper. The control strategy for&#13;\n'JDD' system is extremely simple and it involves very common logic. `JDD' system requires&#13;\na two state controllable damper and jerk sensor. A brief study on controllable damper and&#13;\njerk sensors are presented in this thesis.
(Invited) Flexible and Stretchable Thermoelectric Generators (2017)

Thermoelectricity can be an interesting source of power from otherwise wasted heat. Therefore, for many decades discovery and optimization of new thermoelectric materials has shown important leap toward thermoelectric generator applications. However, from an engineering perspective, structural modifications at the device level can play an important role to maximize the power output. We base our study on device architecture reconfiguration by adopting various in-plane and out-of-plane fractal design to develop flexible and stretchable thermoelectric generator. Physical flexibility allows the devices to be conforming to asymmetric surfaces and mechanical stretching allows to dynamically controlling the distance between the hot and cold end in a thermoelectric generator. This way, one can tune the distance, maximize the temperature difference and maintain a high temperature difference which directly relates to efficiency of a thermoelectric generator. Adopting low cost materials like paper and Off-Stoichiometry Thiol-Enes (OSTE) as structural materials we demonstrate the integration strategy to rationally design materials, processes and devices for flexible and stretchable thermoelectric generators.
Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation : longitudinal analyses in middle-aged men (2007)

Altered fatty acid (FA) composition is related to insulin resistance and CVD. One possible mediator may be inflammation, but longitudinal data relating FA composition to inflammation taking insulin resistance into account are limited. We investigated the long-term association between FA composition and C-reactive protein (CRP) concentrations in a large population-based cohort study in 767 men followed for 20 years. The association between FA composition in serum cholesteryl esters at age 50 and CRP concentrations at age 70 was investigated using linear regression. In addition, desaturase activities (stearoyl-CoA desaturase-1 (SCD-1), Delta5- and Delta6-desaturase) were estimated using FA product-to-precursor ratios. Insulin resistance was measured directly at follow-up by euglycaemic clamp. After adjusting for confounders (smoking, physical activity, alcohol intake, obesity and erythrocyte sedimentation rate) CRP concentrations were inversely associated with the proportion of 18:2n-6 (P = 0.002) and positively associated with 16:1n-7 (P = 0.008), 18:1n-9 (P = 0.0003), 20:5n-3 (P = 0.04) and estimated SCD-1 (P = 0.005) and Delta6-desaturase (P = 0.02) activities. After adding insulin resistance to the model, 18:1n-9, 18:2n-6 and SCD-1 remained significant predictors of CRP. A FA composition indicating low intake of 18:2n-6, high intake of SFA and high SCD-1 activity is, in a Swedish population of middle-aged men, associated with CRP concentrations 20 years later, even independently of obesity and insulin resistance.
Supplementary Fig. S4 from <i>In vivo</i> target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies (2023)

Supplementary Fig. S4 from &lt;i&gt;In vivo&lt;/i&gt; target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies
Cell membrane capsules as biomimetic drug carriers (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Heterojunctions in photovoltaic devices (1977)

Heterojunctions have interesting optical properties which make them attractive for solar cells. Several types of heterostructure solar cells have been investigated: heteroface, abrupt heterojunction, and graded‐gap heterojunction solar cells. The primary advantage of heterostructure cells is the enhanced short‐wavelength response although there is potential for low‐cost cells with polycrystalline material. The improvement in solar‐cell performance for heterojunctions depends upon the selection of semiconductors with useful energy gaps that are closely matched in lattice‐spacing and thermal‐expansion coefficients. The importance of the heterojunction interface and its dependence on material properties is discussed. Various fabrication methods are discussed and their application to the different types of heterostructures. Recent performance data for material systems representative of each type of heterostructure cell are discussed and considered in terms of maximum expected performance.
Correlations between the sol fraction and concentration of elastically active network chains (1977)

Relations between the concentration of elastically active network chains in the gel, veg, and the weight fraction of the gel, wg′ have been examined in crosslinked systems obtained by stepwise alternating polyaddition of a mixture of a tri- and bi-functional monomer bearing one kind of functional groups to a bifunctional monomer bearing another kind of groups. A reduction factor has been found bringing the dependence between log veg and wg almost to a single curve independent of the parameters characterising the initial composition of the system and conversion of the functional groups.
Interactive MATLAB based project learning in a robotics course: Challenges and achievements (2021)

<p style="text-indent:20px;">This paper illustrates the conducted efforts for deploying an interactive project-based learning for robotics course using MATLAB. This project is part of a first course on robotics at the graduate level. The course combines both the theoretical and practical aspects to achieve its goals. The course consists of a set of laboratory sessions ends with a class project, these labs experimentally illustrate the modeling, simulation, path-planning and control of the Robot, using the robotics toolbox under MATLAB tools as well as physical interaction with the different robot platforms. The interaction between the student and the physical robot platforms is finally addressed in the class project; in this project, two tasks are considered. The first one is to control a 5DoF robot manipulator to perform a pick and place task. Initially the task is simulated under MATLAB robotics toolbox; the robot is commended to pick objects from initially known poses and stacks them in target poses. Furthermore, the robot manipulator in the second part of the project, with the aid of a vision system, is commended to work as an autonomous robotic arm that picks up colored objects, and then places them in different poses, based on their identified colors. The demonstrated results from the course evolution and assessment tools reflect the benefits of high-level deployment of robot platform in interactive project based learning to increase the students' performance in the course, about 100% and 75% of the student groups successfully completed the required tasks in the project first part and second part respectively.
On the convergence of statistics in simulations of stationary turbulent flows (2021)

When reporting statistics from simulations of statistically stationary chaotic phenomenon, it is important to verify that the simulations are time-converged. This condition is connected with the statistical error or number of digits with which statistics can be reliably reported. In this work we consider homogeneous and isotropic turbulence as a model problem to investigate statistical convergence over finite simulation times. Specifically, we investigate the time integration requirements that allow meaningful reporting of the statistical error associated with finiteness of the temporal domain. We address two key questions: 1) What is the appropriate range of sampling frequency in large eddy time units? and 2) How long should a simulation be performed in terms of large eddy time so that the statistical error could be reliably reported. Our results indicate that proper sampling frequency is on the order of 10 large eddy time scale. More importantly, we find that reliable reporting of statistical errors requires simulation durations orders of magnitude longer than typically performed. Our observations of sampling frequency for homogeneous isotropic turbulence are also shown to hold in turbulent channel flow.
Network simulation and evaluation for the size reduction of a given topology (2016)

Running on a size-reduction network simulated by a given large-scale topology can obviously enhance the time efficiency. In this paper, we realize the size-reduction using the input extracting of a network simulator and evaluate the similarity between the size-reduction and given topologies using multiple criterions. The evaluation result verifies that the network simulation with input extracting is effective for the size reduction.
Reading and Writing the Blood-Brain Barrier: Relevance to Therapeutics (2006)

The blood-brain barrier (BBB) serves to protect the central nervous system (CNS) from damage by exogenous molecules. In doing so, it also can prevent some drugs from reaching their sites of action. Accordingly, a variety of methods for bypassing the BBB have been developed. Ekwuribe et al. recently patented a method for drug conjugation in order to increase lipophilicity, and therefore BBB permeability. Shalev developed a device for opening the barrier via parasympathetic nerve fiber stimulation and Gudkov et al. produced compounds that modulate the activity of multidrug transporter proteins, by either increasing or decreasing the selective permeability of the BBB. A variety of CNS disorders contribute to barrier disruption, and detection of this opening can be used for both diagnostic purposes and for determining time periods when drugs can more easily enter the CNS. While expensive and time-consuming imaging techniques are currently used for this purpose, Janigro et al. have devised a method for detecting plasma levels of S100beta, a peripheral protein marker for BBB disruption. These techniques for both "reading" and "writing" the BBB will help new and old medications to reach their pharmacological targets in the CNS.
High-Resolution Melting Approach to Efficient Identification and Quantification of H275Y Mutant Influenza H1N1/2009 Virus in Mixed-Virus-Population Samples (2011)

The single-nucleotide variation 823C to T (His275Tyr), responsible for oseltamivir drug resistance has been detected in some isolates of the influenza A/H1N1/2009 virus. Early detection of the presence of this oseltamivir-resistant strain allows prompt consideration of alternative treatment options. An isolated-probe-asymmetric amplification PCR (Roche LightCycler v2.0) and high-resolution melting (HRM) method using unlabeled probes and amplified products (Idaho LightScanner 32) was designed and optimized to detect and estimate the proportion of H275Y mutants in influenza A/H1N1/2009 virus samples. The lower limit of quantification within the linear range of PCR assay detection was 200 copies/reaction. The melting peaks of the H275Y-specific unlabeled probe for the wild-type A/H1N1/2009 and H275Y mutant viruses were clearly distinguishable at 65.5°C and 69.0°C, respectively, at various ratios of wild-type/mutant virus population standards. The 95% detection limit for the 10% mutant sample pool was 1,200 copies/reaction (95% confidence interval, 669.7 to 3,032.6 copies/reaction). This HRM assay was tested with 116 archived clinical specimens. The quantitative HRM results obtained with samples containing mixed mutant-wild-type virus populations, at threshold cycle (C(T)) values of <29, compared well to those obtained with a pyrosequencing method performed by an independent laboratory. The quantitative feature of this assay allows the proportions of mutant and wild-type viral populations to be determined, which may assist in the conventional clinical management of infected patients and potentially more preemptive clinical management. This validated quantitative HRM method, with its low running cost, is well positioned as a rapid, high-throughput screening tool for oseltamivir resistance mutations in influenza A/H1N1/2009 virus-infected patients, with the potential to be adapted to other influenza virus species.
Natural Voice-Enabled CAD: Modeling via Natural Discourse (2009)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Your Children's Meals (1949)

Your Children's Meals Get access Ronald Mac Keith Ronald Mac Keith Search for other works by this author on: Oxford Academic PubMed Google Scholar British Medical Bulletin, Volume 6, Issue 1-2, 1949, Page 144, https://doi.org/10.1093/oxfordjournals.bmb.a073460 Published: 01 January 1949
Cytotoxic effect of the association of BCNU with rhein or lonidamine on a human glioma cell line. (1991)

The effect of association of 1,3-bis-(2-chloroethyl)-l-nitrosourea (BCNU)- Rhein (RH) and BCNU-Lonidamine (LND) on the clonogenic activity of human glioma cells was evaluated. Both RH and LND modulate the lethal effect of BCNU regardless of the schedule of treatment. The analysis of the interactions, performed with the isbolar method according to Berembaum, demonstrates an additivity of the effects. The possible mechanisms as well as the implications for the design of brain tumor schedule treatment are discussed.
Compact and robust incoherent holographic correlator using a surface-emitting laser-diode array (1991)

A compact and robust holographic correlator using a vertical-cavity surface-emitting microlaser diode array is described. The system is based on the unique coherence property of the surface-emitting microlaser array: temporally highly coherent and spatially incoherent. The performance of the system is experimentally demonstrated, and the application of the system for neural network implementations is proposed.
Preparation Artefacts in Proteomics: Technological Issues (2006)

Abstract In addition to taking into account the more than 200 endogenously produced posttranslational modifications, a detailed analysis of proteins separated by two‐dimensional electrophoresis must consider other modifications that a protein can experience during the various steps of its separation.
On the role of phonons in intermediate valence compounds (1979)

The influence of phonons on the pressure-temperature (P, T) phase diagram of intermediate valence compounds is investigated. It is shown that due to phonon induced 4f-5d interband transitions, the renormalized value Ṽ of the hybridization energy V of 4f and conduction electrons may become zero and change its sign and that this is a necessary condition for a discontinuous change of the occupation of the 4f state. The model describes correctly the positive slope (dP/dT > 0) of the phase boundary of the mixed valence state which terminates in a critical point.
Re: ???Effectiveness of the Auscultatory Method in Predicting Feeding Tube Location??? (1992)

A clinical study was conducted to determine the extent to which sounds generated by air insufflations through feeding tubes could be used to predict where the tubes' ports ended in the gastrointestinal tract (esophagus, stomach or proximal small intestine), and to differentiate between gastric and respiratory placement. Sounds generated by a series of air insufflations through the tubes of 85 acutely-ill adult subjects were recorded. One hundred fifteen usable tape-recordings of sound sequences were obtained. The principal investigator later played the tapes for the research team members (who were also skilled clinicians) so that they could independently record their impressions of the sounds. (No identification of subjects or tube positions were given on the tapes; however, each site of auscultation was announced.) The results were collated and compared against the hypotheses and actual tube location (as determined by X-ray). Overall, the average percentage of correct classifications of each tape was 34.4%. Descriptive data were reported for three subjects with feeding tubes inadvertently positioned in the respiratory tract; air insufflations were clearly audible in 2 of the 3 cases. Clinicians should not rely on the auscultatory method to differentiate gastric from intestinal placement, nor gastric from respiratory placement of feeding tubes.
Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia (2003)

Large granular lymphocyte (LGL) leukemia is a lymphoproliferative disorder often associated with rheumatoid arthritis. The etiology of LGL leukemia is not known. In order to better understand the pathogenesis of LGL leukemia, we analyzed differential gene expression using microarray technology. We found that approximately 80 genes were up-regulated and 12 genes were down-regulated when compared to normal peripheral blood mononuclear cells (PBMC). In the present study, we were interested in a group of genes involved in cytotoxic function. The up-regulated genes involved in cytotoxic function were serine proteinases (granzymes A, B, H and K) cysteine proteinases [cathepsin C, cathepsin W (lymphopain)], calpain small subunit and caspase-8. In addition, a pore-forming protein perforin, was also up-regulated. Northern blot analysis and RNase protection assays (RPA) confirmed that these genes were over-expressed in the majority of samples from LGL leukemia patients. Of interest, proteolytic inhibitors such as cystatin C, A, alpha-1 antitrypsin and metalloproteinase inhibitors were down-regulated in leukemic LGL when compared to normal peripheral blood mononuclear cells. Importantly, the pattern of gene expression in leukemic LGL resembles that seen in activated cytotoxic T cells (CTL).