gebhart/patrepeval huggingface dataset:
Perception-based expert system with application to clinical decision making (2005)

The vast majority of medical decision support systems operate on crisp numerical information. This paper describes an approach based on the paradigm of computing with perceptions that accounts for the imprecise character of clinical data. The proposed reasoning system handles imprecise input information in a computationally inexpensive way. An application example for decision support in the management of chronic anemia demonstrates the feasibility of the proposed approach.
Corporate Governance and Financial Inclusion (2021)

The paper focuses on a scantly researched phenomenon, namely, the extent to which financial inclusion is influenced by corporate governance practices. The question that normally arises is whether corporate governance practices are tailored to supporting the financial inclusion mandate. The other question is whether there are certain corporate governance practices that advance financial inclusion. This paper reviews extant empirical literature on these matters with a view of stimulating debate on the subject. Cognisant that institutions that advance financial inclusion are largely financial institutions, the starting point is relating to contemporary corporate governance practice in financial institutions. We know that financial institutions belong to a specific class of corporations whose failure affects society at large because of the financial services they provide. As a result, they are heavily regulated and their corporate governance structures are bound to differ from those of conventional firms. Similarly, we know that financial inclusion institutions are special types of financial institutions with mandates to provide financial services to underserved population segments which equally require special treatment. The scant literature available shows, albeit not conclusive, some evidence of a positive relationship between sound corporate governance and financial inclusion. However, more research on how corporate governance affects different dimensions of financial inclusion is recommended.
Statistical and metric properties of long-chain combs (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStatistical and metric properties of long-chain combsJ. E. G. LipsonCite this: Macromolecules 1993, 26, 1, 203–207Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/ma00053a031https://doi.org/10.1021/ma00053a031research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CHARACTERIZING THE HUBBLE SPACE TELESCOPE USING RETRIEVAL ALOGORITHMS (1991)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. R. FIENUP, "CHARACTERIZING THE HUBBLE SPACE TELESCOPE USING RETRIEVAL ALOGORITHMS," Optics & Photonics News 2(12), 41-42 (1991) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders (2017)

<b>Background:</b> Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases. Eight of these result from variants of connexin 26 (Cx26), a protein critically involved in cell-cell signaling in the inner ear and skin. Lack of non-toxic drugs with defined mechanisms of action poses a serious obstacle to therapeutic interventions for diseases caused by mutant connexins. In particular, molecules that specifically modulate connexin hemichannel function without affecting gap junction channels are considered of primary importance for the study of connexin hemichannel role in physiological as well as pathological conditions. Monoclonal antibodies developed in the last three decades have become the most important class of therapeutic biologicals. Recombinant methods permit rapid selection and improvement of monoclonal antibodies from libraries with large diversity. <b>Methods:</b> By screening a combinatorial library of human single-chain fragment variable (scFv) antibodies expressed in phage, we identified a candidate that binds an extracellular epitope of Cx26. We characterized antibody action using a variety of biochemical and biophysical assays in HeLa cells, organotypic cultures of mouse cochlea and human keratinocyte-derived cells. <b>Results:</b> We determined that the antibody is a remarkably efficient, non-toxic, and completely reversible inhibitor of hemichannels formed by connexin 26 and does not affect direct cell-cell communication via gap junction channels. Importantly, we also demonstrate that the antibody efficiently inhibits hyperative mutant Cx26 hemichannels implicated in autosomal dominant non-syndromic hearing impairment accompanied by keratitis and hystrix-like ichthyosis-deafness (KID/HID) syndrome. We solved the crystal structure of the antibody, identified residues that are critical for binding and used molecular dynamics to uncover its mechanism of action. <b>Conclusions:</b> Although further studies will be necessary to validate the effect of the antibody <i>in vivo</i>, the methodology described here can be extended to select antibodies against hemichannels composed by other connexin isoforms and, consequently, to target other pathologies associated with hyperactive hemichannels. Our study highlights the potential of this approach and identifies connexins as therapeutic targets addressable by screening phage display libraries expressing human randomized antibodies.
A universal optical approach to enhancing efficiency of organic-based photovoltaic devices (2012)

We report a new optical approach that can be used to enhance light harvesting in many different organic-based photovoltaic cells. A transparent polymer microlens array moulded on the light incident surface increases the light path in the active layer and reduces surface reflection, resulting in a 15–60% relative increase in overall cell efficiency.
Gap Plasmons and Near-Field Enhancement in Closely Packed Sub-10 nm Gap Resonators (2013)

Pairs of metal nanoparticles with a sub-10 nm gap are an efficient way to achieve extreme near-field enhancement for sensing applications. We demonstrate an attractive alternative based on Fabry-Perot type nanogap resonators, where the resonance is defined by the gap width and vertical elongation instead of the particle geometry. We discuss the crucial design parameters for such gap plasmons to produce maximum near-field enhancement for surface-enhanced Raman scattering and show compatibility of the pattern processing with low-cost and low-resolution lithography. We find a minimum critical metal thickness of 80 nm and observe that the mode coupling from the far field increases by tapering the gap opening. We also show the saturation of the Raman signal for nanogap periodicities below 1 μm, demonstrating efficient funneling of light into such nanogap arrays.
Open science and data sharing in cognitive neuroscience with MouseBytes and MouseBytes+ (2023)

Open access to rodent cognitive data has lagged behind the rapid generation of large open-access datasets in other areas of neuroscience, such as neuroimaging and genomics. One contributing factor has been the absence of uniform standardization in experiments and data output, an issue that has particularly plagued studies in animal models. Touchscreen-automated cognitive testing of animal models allows standardized outputs that are compatible with open-access sharing. Touchscreen datasets can be combined with different neuro-technologies such as fiber photometry, miniscopes, optogenetics, and MRI to evaluate the relationship between neural activity and behavior. Here we describe a platform that allows deposition of these data into an open-access repository. This platform, called MouseBytes, is a web-based repository that enables researchers to store, share, visualize, and analyze cognitive data. Here we present the architecture, structure, and the essential infrastructure behind MouseBytes. In addition, we describe MouseBytes+, a database that allows data from complementary neuro-technologies such as imaging and photometry to be easily integrated with behavioral data in MouseBytes to support multi-modal behavioral analysis.
344. Studies of trifluoroacetic acid. Part XVIII. Reaction of N-aroylglycines with perfluoro-carboxylic anhydrides (1961)

E. J. Bourne, J. Burdon, V. C. R. McLoughlin and J. C. Tatlow, J. Chem. Soc., 1961, 1771 DOI: 10.1039/JR9610001771
Emerging technologies for point-of-care genetic testing (2007)

In the coming years, genetic test results will be increasingly used as indicators that influence medical decision making. Novel instrumentation that is able to detect relevant mutations in a point-of-care setting is being developed to facilitate this increase, frequently as a spin-off from recent research in the area of biothreat monitoring. This market review will describe the current generation of instrumentation that is most suitable for use in a point-of-care setting; it will also try to identify some of the technologies that will make-up the next generation of instrumentation currently being prepared for the market.
Energy‐Efficient Small‐Scale Ammonia Synthesis Process with Plasma‐Enabled Nitrogen Oxidation and Catalytic Reduction of Adsorbed NOx (2022)

Industrial ammonia production without CO<sub>2</sub> emission and with low energy consumption is one of the technological grand challenges of this age. Current Haber-Bosch ammonia mass production processes work with a thermally activated iron catalyst needing high pressure. The need for large volumes of hydrogen gas and the continuous operation mode render electrification of Haber-Bosch plants difficult to achieve. Electrochemical solutions at low pressure and temperature are faced with the problematic inertness of the nitrogen molecule on electrodes. Direct reduction of N<sub>2</sub> to ammonia is only possible with very reactive chemicals such as lithium metal, the regeneration of which is energy intensive. Here, the attractiveness of an oxidative route for N<sub>2</sub> activation was presented. N<sub>2</sub> conversion to NO<sub>x</sub> in a plasma reactor followed by reduction with H<sub>2</sub> on a heterogeneous catalyst at low pressure could be an energy-efficient option for small-scale distributed ammonia production with renewable electricity and without intrinsic CO<sub>2</sub> footprint.
ChemInform Abstract: Variable‐Temperature 17O NMR Study of Oxygen Motion in the Anionic Conductor Bi26Mo10O69. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A 90-${\hbox {dB}}\Omega$ 10-Gb/s Optical Receiver Analog Front-End in a 0.18-$\mu{\hbox {m}}$ CMOS Technology (2007)

A 10-Gb/s 90-dBOmega optical receiver analog front-end (AFE), including a transimpedance amplifier (TIA), an automatic gain control circuit, and a postamplifier (PA), is fabricated using a 0.18-mum CMOS technology. In contrast with a conventional limiting amplifier architecture, the PA is consisted of a voltage amplifier followed by a slicer. By means of the TIA and the PA codesign, the receiver front-end provides a -3-dB bandwidth of 7.86 GHz and a gain bandwidth product (GBW) of 248.5 THz-Omega. The tiny photocurrent received by the AFE is amplified to a differential voltage swing of 900 mV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> when driving 50-Omega output loads. The measured input sensitivity of the optical receiver is -13 dBm at a bit-error rate of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> with a 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> -1 pseudorandom test pattern. The optical receiver AFE dissipates a total power of 199 mW from a 1.8-V supply, among which 35 mW is consumed by the output buffer. The chip size is 1300 mumtimes1796 mum
A realism-based approach to the evolution of biomedical ontologies. (2006)

We present a novel methodology for calculating the improvements obtained in successive versions of biomedical ontologies. The theory takes into account changes both in reality itself and in our understanding of this reality. The successful application of the theory rests on the willingness of ontology authors to document changes they make by following a number of simple rules. The theory provides a pathway by which ontology authoring can become a science rather than an art, following principles analogous to those that have fostered the growth of modern evidence-based medicine. Although in this paper we focus on ontologies, the methodology can be generalized to other sorts of terminology-based artifacts, including Electronic Patient Records.
Kongenitaler präpubischer Sinus: Ätiologie und Therapie (2003)

The immunohistochemical examination of the epithelium of Type II CPS proved, in this case, the existence of urothelium as the inner surface of the sinus. In view of this evidence it appears likely that the congenital prepubic sinus can be classified etiologically as an incomplete urethral duplication.
Pure red cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities [see comments] (1996)

From 1980 through 1994, we identified 47 adult patients with acquired pure red cell aplasia (median age, 64 years; range, 22 to 84 years). Associated clinical disorders included T-cell large granular lymphocytic (LGL) leukemia, thymoma, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma. Review of bone marrow findings in 40 patients showed absence of erythroid precursors in 14 patients and rare pronormoblasts in 26. None had morphologic evidence of myelodysplasia. T-cell receptor gene rearrangement studies with Southern blot technique in 14 patients showed clonal rearrangements in nine. Karyotypic analyses performed in 28 patients showed clonal abnormalities in four. Overall, 28 of 47 patients (60%) responded to immunosuppressive therapy, but none were the patients with cytogenetic abnormalities. There was a trend toward superior response to immunosuppressive agents in the patients with T-cell LGL leukemia. Cyclophosphamide, with or without corticosteroids, was the most useful treatment agent. Cyclosporine A was effective for refractory disease. Neither the presence of an associated clinical disorder nor the existence of detectable erythroid precursors affected overall survival. We conclude that (1) T-cell LGL leukemia is the disorder most commonly associated with pure red cell aplasia, (2) the presence of clonal cytogenetic abnormality predicts poor response to immunosuppressive therapy, and (3) oral cyclophosphamide and cyclosporine A are effective treatment regimens.
Cyto- and genotoxicological assessment and functional characterization of N -vinyl-2-pyrrolidone–acrylic acid-based copolymeric hydrogels with potential for future use in wound healing applications (2010)

This study investigated the toxicity of N-vinyl-2-pyrrolidone-acrylic acid copolymer hydrogels crosslinked with ethylene glycol dimethacrylate or poly(ethylene glycol) dimethacrylate. There is a pressing need to establish the toxicity status of these new copolymers because they may find applications in future wound healing processes. Investigations revealed that the capacity of these hydrogels for swelling permitted the retention of high amounts of water yet still maintaining structural integrity. Reverse phase HPLC analysis suggested that unreacted monomeric base material was efficiently removed post-polymerization by applying an additional purification process. Subsequently, in vitro toxicity testing was performed utilizing direct and indirect contact exposure of the polymers to human keratinocytes (HaCaT) and human hepatoma (HepG2) cells. No indication of significant cell death was observed using the established MTT, neutral red (NR) and fluorescence-based toxicity endpoint indicators. In addition, the alkaline Comet assay showed no genotoxic effects following cell exposure to hydrogel extracts. Investigations at the nucleotide level using the Ames mutagenicity assay demonstrated no evidence of mutagenic activity associated with the polymers. Findings from this study demonstrated that these hydrogels are non-cytotoxic and further work can be carried out to investigate their potential as a wound-healing device that will impact positively on patient health and well-being.
Eigenvalue tests and distributions for small sample order determination for complex Wishart matrices (1995)

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Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1) (2003)

The tumor suppressor p53 is regulated in part by binding to cellular proteins. We used p53 as bait in the yeast two-hybrid system and isolated homeodomain-interacting protein kinase 1 (HIPK1) as a p53-binding protein. Deletion analysis showed that amino acids 100-370 of p53 and amino acids 885-1093 of HIPK1 were sufficient for HIPK1-p53 interaction. HIPK1 was capable of autophosphorylation and specific serine phosphorylation of p53. The HIPK1 gene was highly expressed in human breast cancer cell lines and oncogenically transformed mouse embryonic fibroblasts. HIPK1 was localized to human chromosome band 1p13, a site frequently altered in cancers. Gene-targeted HIPK1-/- mice were grossly normal but oncogenically transformed HIPK1 -/- mouse embryonic fibroblasts exhibited reduced transcription of Mdm2 and were more susceptible than transformed HIPK1+/+ cells to apoptosis induced by DNA damage. Carcinogen-treated HIPK1 -/- mice developed fewer and smaller skin tumors than HIPK1+/+ mice. HIPK1 may thus play a role in tumorigenesis, perhaps by means of the regulation of p53 and/or Mdm2.
Chondroitin and Dermatan Sulfate Bioinks for 3D Bioprinting and Cartilage Regeneration (2022)

Cartilage is a connective tissue which a limited capacity for healing and repairing. In this context, osteoarthritis (OA) disease may be developed with high prevalence in which the use of scaffolds may be a promising treatment. In addition, three-dimensional (3D) bioprinting has become an emerging additive manufacturing technology because of its rapid prototyping capacity and the possibility of creating complex structures. This study is focused on the development of nanocellulose-alginate (NC-Alg) based bioinks for 3D bioprinting for cartilage regeneration to which it is added chondroitin sulfate (CS) and dermatan sulfate (DS). First, rheological properties are evaluated. Then, sterilization effect, biocompatibility, and printability on developed NC-Alg-CS and NC-Alg-DS inks are evaluated. Subsequently, printed scaffolds are characterized. Finally, NC-Alg-CS and NC-Alg-DS inks are loaded with murine D1-MSCs-EPO and cell viability and functionality, as well as the chondrogenic differentiation ability are assessed. Results show that the addition of both CS and DS to the NC-Alg ink improves its characteristics in terms of rheology and cell viability and functionality. Moreover, differentiation to cartilage is promoted on NC-Alg-CS and NC-Alg-DS scaffolds. Therefore, the utilization of MSCs containing NC-Alg-CS and NC-Alg-DS scaffolds may become a feasible tissue engineering approach for cartilage regeneration.
The HP Time Vault Service: Innovating the Way Confidential Information is Disclosed, at the Right Time (2002)

This paper focuses on the problem of protecting confidential information from unauthorized disclosures, subject to time-based criteria: it is a common issue in the industry, government and day-to-day life. We introduce an innovative service, the Time Vault Service, that leverages the emerging Identity-based Encryption (IBE) cryptography schema to enforce time-based confidentiality of digital documents and simplify their distribution. We discuss the advantages of this approach against a similar approach based on traditional cryptography. A working prototype of the Time Vault Service is described, as proof of the concept
A comparative pilot study of the effects of a dentifrice containing green tea bioflavonoids, sanguinarine or triclosan on oral bacterial biofilm formation. (2000)

The aim of the present study was to evaluate the effect of a green tea bioflavonoid/zinc ascorbate-containing dentifrice (Natural Antioxidant Toothpaste) on bacterial plaque biofilm accumulation. Plaque biofilms were formed and observed on saliva-conditioned synthetic hydroxyapatite disks (HA) over 4 days. Two test treatments were performed daily over a 4-day experimental period for a total of 8 treatments. Four test dentifrices were evaluated: a 0.1% bioflavonoid/0.2% zinc ascorbate; a non-active control test dentifrice; a 0.075% sanguinarine/2.0% zinc chloride dentifrice; and a 0.3% triclosan dentifrice. The repeated treatment of the HA with the green tea bioflavonoid/zinc ascorbate, the sanguinarine/zinc chloride, or the triclosan dentifrice resulted in significant reductions in total viable plaque biomass when compared to a non-active placebo control dentifrice.