gebhart/patrepeval huggingface dataset:
Coronary flow reserve does not correlate with coronary artery calcification in patients with end-stage renal disease (2016)

1674 Objectives Chronic kidney disease (CKD) is a major risk factor for the development of coronary artery disease (CAD). Patients with CKD have an increased risk for myocardial infarction, heart failure and cardiac death, while particularly patients with end-stage renal disease (ESRD) are at high risk. Myocardial perfusion imaging (MPI) with PET is used for the detection of hemodynamically relevant CAD in CKD patients. Coronary flow reserve (CFR) and coronary artery calcification (CAC) have been shown to be prognostic markers for cardiovascular events. We herein questioned the relationship of these relevant morphological and functional parameters in kidney transplant waitlist patients with ESRD. Methods 48 patients (32 male; mean age 52 ± 12.8 years) underwent list-mode driven, quantitative myocardial perfusion 13NH3 PET/CT under hyperemic and resting conditions. Myocardial perfusion defects (summed stress score, SSS 蠅 4) were detected in the static PET images while absolute rest and hyperemic myocardial blood flow (MBF) and CFR were calculated from the dynamic PET images. A CFR ≤ 1.8 was considered as pathologic. CAC was derived from the non-ECG triggered, low-dose CT scan of the chest which was acquired for attenuation correction of the PET data and expressed as Agatston score.
							
							 Results CFR was impaired in six patients (12.5%);one patient presented with an additional perfusion defect. Static MPI showed stress perfusion defects in another five patients (10%) in which CFR was preserved. Mean Agatston score was 425 ± 893 (range 0 - 3957). While there was a moderate negative correlation between hyperemic MBF and CACB (r=-0.304; p=0.038), CFR did not significantly correlate with CAC (r=-0.111; p=0.46). Age was negatively correlated with hyperemic MBF (r=-0.518; p<0.001) and CFR (r=-0.39; p<0.01) but not significantly with CAC (r=0.27; p=0.071).
							
							 Conclusions Although established as markers for atherosclerosis and predictors for cardiovascular events in non-CKD patients, CFR and CAC do not correlate in patients with ESRD. While CAC was not correlated with age, hyperemic MBF and CFR decrease with increasing age of the patients. Notably, myocardial perfusion defects detected by static PET imaging in ESRD patients do not necessarily come along with an impaired CFR, which points towards the need for a differentiated cardio vascular risk assessment in these patients.
Regulation of Thyrotropin Releasing Hormone Degrading Enzymes in Rat Brain and Pituitary by L‐ 3,5,3′‐Triiodothyronine (1989)

The effect of treatment with L-3,5,3'-triiodothyronine (T3) on the levels of pyroglutamyl peptidase I and pyroglutamyl peptidase II in rat brain regions, pituitary, and serum was studied. Pyroglutamyl peptidase I cleaves pyroglutamyl peptides such as thyrotropin releasing hormone (TRH), luteinizing hormone releasing hormone, neurotensin, and bombesin, whereas pyroglutamyl peptidase II appears to be specific for TRH. Acute administration of T3 did not affect pyroglutamyl peptidase I in any of the regions studied, whereas pyroglutamyl peptidase II was significantly elevated in frontal cortex and pituitary. Treatment with T3 for 10 or 14 days significantly elevated pyroglutamyl peptidase I in pituitary, hypothalamus, olfactory bulb, hippocampus, and thalamus. Chronic T3 treatment elevated pyroglutamyl peptidase II in frontal cortex and in serum. These studies demonstrate regulation of neuropeptide degrading enzymes by thyroid hormones in vivo. This regulation may play a role in the negative feedback control of thyroid status by T3.
Improving the Durability of Amorphous Vanadium Oxide Thin-Film Electrode in a Liquid Electrolyte (2003)

We report on the effects of depositing a protective inorganic solid electrolyte coating on amorphous electrode in terms of long-term cycling efficiency and stability of the in a liquid electrolyte. Two thin-film electrodes were fabricated for extensive cyclic durability testing in a carbonate liquid electrolyte: One film had no overlying coating while the other had a protective thin film of solid lithium ion conducting The protected exhibited improved durability in terms of constant capacity with repeated cycling up to 800 cycles, while the uncoated electrode displayed significant capacity loss. Our results demonstrate that deposition of an inorganic solid electrolyte on amorphous films serves as a protective overlayer and enhances the long-term cycling efficiency and stability of the in a liquid electrolyte. © 2003 The Electrochemical Society. All rights reserved.
Quadrupole and hexadecapole ordering inDyB2C2:Direct observation with resonant x-ray diffraction (2004)

Direct evidence of the spatial ordering of Dy $4f$ quadrupole and hexadecapole moments in ${\mathrm{DyB}}_{2}{\mathrm{C}}_{2}$ is demonstrated by resonant x-ray diffraction enhanced by an electric quadrupole event $(E2$ resonance) at the Dy ${L}_{\mathrm{III}}$ absorption edge. The diffraction data show that the structural phase transition at ${T}_{\mathrm{Q}}=24.7\mathrm{K}$ is accompanied by a reduction in the symmetry of the Dy site to $2/m,$ from $4/m,$ and the spatial ordering of the time-even Dy multipoles with ${A}_{g}$ character. Below ${T}_{\mathrm{Q}}$ the crystal structure is described by the space group ${P4}_{2}/mnm$ and Dy ions occupy sites $(4c).$ The distortion at ${T}_{\mathrm{Q}}$ involves the lattice occupied by B and C ions, and it amounts to a buckling of B-C planes that are normal to the two-fold rotation axis of $2/m.$ An immediately plausible model of low-energy Dy states correlates data on the specific heat, our x-ray diffraction signals, and magnetic ordering below 15.3 K which has been observed in magnetic neutron diffraction.
Enumeration and characterization of standard plate count bacteria in chlorinated and raw water supplies (1980)

Nearly 700 standard plate count (SPC) bacteria were isolated from drinking water and untreated surface water and identified according to a scheme developed to permit the rapid, simple classification of microorganisms to genus, species, or group. Actinomycetes and Aeromonas species were the two most common groups of SPC bacteria in chlorinated distribution water. Aeromonas spp. and Enterobacter agglomerans were the two most common groups of SPC bacteria in raw water. Identification of bacterial populations before and after contact with chlorine (1 to 2 mg/liter) for 1 h revealed that chlorination selected for gram-positive bacteria. Water that contained high densities of bacteria known to be antagonistic to coliforms had low coliform isolation rates. The membrane filtration technique for enumerating SPC bacteria recovered significantly higher numbers (P < 0.001) than the standard pour plate technique.
Impact of junctional ectopic tachycardia on postoperative morbidity following repair of congenital heart defects (2002)

Postoperative JET adds considerably to morbidity after congenital cardiac surgery, and is particularly frequent after TOF repair. Aggressive treatment with cooling and/or amiodarone is mandatory, but correlates with increased mechanical ventilation time and CICU stay. Better understanding of the mechanism underlying JET is required to achieve prevention, faster arrhythmic conversion, and reduction of associated in-hospital morbidity.
Use of Polyethylene Glycol to Separate Free and Antibody-Bound Peptide Hormones in Radioimmunoassays† (1971)

Aqueous polyethylene glycol causes precipitation of antibody-bound peptide hormones labeled with radioactive iodine with little or no precipitation of free hormones. Based on this finding, a method of separation has been developed and applied to radioimmunoassays of insulin, parathyroid hormone, growth hormone and arginine vasopressin. The new method provides several advantages over the double-antibody precipitation method. It appears particularly valuable in immunoassays of substances of low molecular weight.
Undressing a Water Marble on Oil Film (2017)

Due to a great contact angle with substrate as well as low resistance to motion and stable structure of superhydrophobic powder shell, liquid marbles display attractive potential for easy actuation and manipulation. This work shows the dynamical behavior of a rolling liquid marble on oil film. Static liquid marbles display a much larger contact angle than water drops on an oil film. When liquid marbles move on oil film, three consecutive stages are observed. The first stage exhibits a linear relationship versus the remaining time, implying that liquid marbles are rolling on oil film and the attached particles are multilayer. When the particles become locally monolayer, the transient stage begins and the advancing angle is much larger than receding angle. At this time, liquid marble is sliding rather than rolling. Finally, liquid marble is captured by oil film and spreads to be a cap owing to the liquid–liquid contact. This work introduces an approach to partially undress particle layers and disintegrate liquid marbles, expecting to facilitate the optical probing from the transparent bottom of liquid marbles.
The decorative arts within art historical discourse where is the dialogue now and where is it heading? (2014)

Report on the panel held in New York in 2013 titled ‘The Decorative Arts Within Art Historical Discourse: Where is the Dialogue Now and Where is It Heading?’ at the College Art Association annual meeting. The essay sets out the parameters for the conference, elucidates which texts have played important roles in the formation of the discourse to date and gives précises of the papers that were delivered at the conference along with their varying viewpoints.
Control of Eyelid Retraction Associated With Graves' Disease With Botulinum A Toxin (1994)

Two patients had satisfactory control of eyelid retraction associated with thyroid orbitopathy with repeated treatment of the levator palpebrae superioris muscle with botulinum A toxin. The effects of the toxin lasted for 3 to 4 months.
Silver nitrate in silver zeolite A: three-dimensional incommensurate guest ordering in a zeolite framework (2006)

We report the results of a detailed examination of the occlusion of silver nitrate in silver zeolite A (AgA). The superlattice reported to occur in (AgNO3)9-AgA was found to melt at between 80 and 100 degrees C on heating and reappear when the sample was cooled down to 80 degrees C. Annealing in this temperature range and rigorous exclusion of water produced an enhancement of the superlattice peaks, which results from ordering of the contents of the zeolite cages. Peaks assigned to the superlattice were indexed with the tetragonal lattice parameters a = 17.440(5) and c = 12.398(4) A and proposed space group P4/nmm. The sharp peaks representing the lattice of the framework (a = 12.3711(5) A, Pm3m) remained largely unaffected by the guest in this compound, which was found to exhibit strong negative thermal expansion. The host and guest lattices are incommensurate with the tetragonal guest lattice being slightly larger than the cubic host in the c-direction and slightly smaller in the a- and b-directions.
Room temperature terahertz detectors based on semiconductor nanowire field effect transistors (2011)

Self-assembled nanowires represent a new interesting technology to be explored in order to increase the cut-off frequency of electronic THz detectors. They can be developed in field effect transistor (FET) and diode geometries exploiting non-linearities of either the transconductance or the current-voltage characteristic as detection mechanism. In this work we demonstrate that semiconductor nanowires can be used as building blocks for the realization of highsensitivity terahertz one-dimensional FET detectors. In order to take advantage of the low effective mass and high mobilities achievable in III-V compounds, we have used InAs nanowires, grown by vapor-phase epitaxy, and properly doped with selenium to control the charge density and to optimize source-drain and contact resistance. The detection mechanism exploits the non-linearity of the transconductance: the THz radiation field is fed at the gate-source electrodes with wide band antennas, and the rectified signal is then read at the drain output in the form of a DC voltage. Responsivity values as large as 1 V/W at 0.3 THz have been obtained, with noise equivalent powers (NEP) &lt; 2 &times; 10<sup>-9</sup> W/&radic;Hz at room temperature. The large existing margins for technology improvements, the scalability to higher frequencies, and the possibility of realizing multi-pixel arrays, make these devices highly competitive as a future solution for THz detection.
Identification of Novel α-Glucosidase Inhibitors by Screening Libraries Based on N- [4-(Benzyloxy) Benzoyl] Alanine Derivatives [1] (2002)

A library of 72 compounds related to N- [4-(benzyloxy) benzoyl]alanine (I) was synthesized, prepared and screened for alpha-glucosidase inhibitory activity. Four compounds showed potent inhibition, six compounds moderate inhibition, and 16 were weak inhibitors. One compound, N- [4-(benzyloxy) benzoyl] serine, was found to be a potent inhibitor of alpha-glucosidase with 100% inhibition at 1 micro M. This inhibitor was at least five times more potent than the lead compound I.
Supplementary Figure 1 from Efficacy and Biological Activity of Imatinib in Metastatic Dermatofibrosarcoma Protuberans (DFSP) (2023)

&lt;p&gt;Supplementary Figure 1. Evidence of tumor regression and inflammatory infiltration in IM-treated metastatic FS-DFSP. IHC staining of a metastatic FS-DFSP lesions derived from patient #4 in Table 1 and 2. Panel A and B show haematoxylin and eosin stains of (a, b) pre-IM and (c, d, e, f) post-IM lesions. Micrograph picture c shows the presence of a cellular depleted area replaced by hyalinized stroma. Panel B displays the intra-tumor presence of inflammatory cells (indicated by the arrows). Original magnification: a and c 25x; d and e 50x; b and f 100x.&lt;/p&gt;
Access to 20 evenly distributed wavelengths over 100 nm using only a single current tuning in a four-electrode monolithic semiconductor laser (1995)

We report improved tuning regularity in a vertical grating assisted codirectional coupler laser with a super-structure grating distributed Bragg reflector (GCSR). Access to 20 wavelengths with SMSR better than 20 dB within a tuning range of 100 nn was obtained with a single current control in a GCSR laser. The total tuning behavior shows a potential of complete wavelength coverage over 100 nm by use of three tuning currents.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
SDN Hypervisors: How Much Does Topology Abstraction Matter? (2018)

SDN network hypervisors realize the virtualization of software-defined networks. They intercept the control path between tenant controllers and their respective virtual Software-Defined Networks (SDN). Over-utilizing SDN hypervisor resources (i.e., CPU) can degrade the control plane performance of the tenants. Although many hypervisor proposals exists, a detailed performance modeling of SDN hypervisors is missing in literature. A precise modeling of the required SDN hypervisor resources, however, is crucial for predictable and reliable operation of virtual software-defined networks. In this paper, we measure and evaluate how topology abstraction can affect the SDN hypervisor CPU utilization. We consider two topology abstraction cases: the (1) transparent and (2) big-switch abstraction. Our measurements taken from a real testbed indicate that the big-switch abstraction can reduce the SDN hypervisor CPU utilization up to $\sim 4\times $. Further, we evaluate different functions to model the SDN hypervisor CPU utilization based on our measurement results. Our evaluations show that a polynomial function provides the lowest fitting error. Motivated by our measurements, we conduct a first-step investigation of the impacts of topology abstraction on the Virtual Network Embedding (VNE) problem. Our initial simulation-based evaluations indicate that different topology abstraction procedures impact the results of the VNE problem.
Protein-Functionalized Gold Nanoparticles as Refractometric Nanoplasmonic Sensors for the Detection of Proteolytic Activity of Porphyromonas gingivalis (2020)

Periodontitis is an inflammatory oral disease that affects a large part of the adult population, causing significant costs and suffering. The key pathogen, Porphyromonas gingivalis, secretes gingipains, which are highly destructive proteases and the most important virulence factors in the pathogenesis of the disease. Currently, periodontitis is diagnosed mainly by mechanical manual probing and radiography, often when the disease has already progressed significantly. The possibilities of detecting gingipain activity in gingival fluid could enable early-stage diagnosis and facilitate treatment. Here, we describe a sensitive nanoparticle-based nanoplasmonic biosensor for the detection of the proteolytic activity of gingipains. Gold nanoparticles (AuNPs) were self-assembled as a submonolayer in multiwell plates and further modified with casein or IgG. The proteolytic degradation of the protein coating was tracked by monitoring the shift in the localized surface plasmon resonance (LSPR) peak position. The sensor performance was investigated using model systems with trypsin and purified gingipains (subtypes Kgp and RgpB) and further validated using supernatants from cultures of P. gingivalis. Proteolytic degradation by proteases in buffer results in a concentration- and time-dependent blueshift of the LSPR band of about 1-2 nm when using casein as a substrate. In bacterial supernatants, the degradation of the protein coating resulted in unspecific binding of proteins present in the complex sample matrix to the nanoparticles, which instead triggered a redshift of about 2 nm of the LSPR band. A significant LSPR shift was seen only in samples with gingipain activity. The sensor showed a limit of detection &amp;amp;lt; 0.1 mu g/mL (4.3 nM), which is well below gingipain concentrations detected in severe chronic periodontitis cases (similar to 50 mu g/mL). This work shows the possibility of developing cost-effective nanoparticle-based biosensors for rapid detection of protease activity for chair-side periodontal diagnostics.
Prevalence of type 5 familial hemophagocytic lymphohistiocytosis in Korea and novel mutations in STXBP2 (2015)

Familial hemophagocytic lymphohistiocytosis (F-HLH or FHL) is a potentially fatal immune dysregulation syndrome with a heterogeneous genetic background. Most recently, STXBP2 has been identified as the causative gene of type 5 FHL (FHL5) with a worldwide distribution. In this study, we investigated the prevalence of FHL5 in Korea. About 50 Korean pediatric patients with HLH who lacked pathogenic mutations in PRF1, UNC13D, or in STX11 from the previous series of 72 patients with HLH were analyzed for STXBP2 mutations by conventional sequencing analyses. As a result, we found one patient with two novel mutations of STXBP2: c.184A>G and c.577A>C. c.184A>G (p.Asn62Asp) was located within a highly conserved region of the STXBP2 protein and predicted to be deleterious. c.577A>C in exon 7 resulted in incomplete splicing mutation with exon 7 skipping concurrent with exon 7-retained transcript with p.Lys193Gln substitution. The frequency of FHL5 was ~1% (1/72) in Korean pediatric patients with HLH. This is the first study on FHL5 in Korea, and the data from a nationwide patient cohort provide another piece of genetic profiles of FHL.
Effects of Irradiation on Survival and Growth of Listeria monocytogenes and Natural Microflora in Vacuum-Packaged Turkey Hams and Breast Rolls (2008)

The effect of electron beam irradiation on the survival and growth of Listeria monocytogenes and natural microflora in oven-roasted turkey breast rolls and turkey hams was evaluated. Slices of turkey breast rolls and hams were inoculated with a 5-strain mixture of L. monocytogenes to achieve 10(6) to 10(7) cfu/cm2; vacuum-packaged; irradiated at 0 (control), 1.0, 1.5, 2.0, or 2.5 kGy; and stored at 4 degrees C for up to 28 d. Numbers of naturally occurring bacteria on sliced turkey hams and breast rolls were 2.72 and 6.22 log10 cfu/cm2, respectively. The values of the radiation dose that results in 90% reduction of viable L. monocytogenes in breast rolls and hams were 0.52 and 0.47 kGy, respectively. For breast rolls, the log10 reductions of L. monocytogenes after irradiation at 1.0 and 2.5 kGy were 1.5 and 4.7, respectively, whereas they were 2.0 and 5.5 for hams. The log10 reductions of aerobic plate count (APC) in breast rolls after 1.0 and 2.0 kGy of irradiation were 2.9 and 5.2, whereas that of hams was < 10 cfu/cm2 after 1.0 and 2.0 kGy of irradiation. In 2.0-kGy irradiated hams, L. monocytogenes grew to 4.82 log10 cfu/cm2 after 28 d of storage at 4 degrees C, whereas APC increased to 2.98 log10 cfu/cm2, respectively. In breast rolls after 14 d of storage, APC in 1.0-kGy irradiated samples increased to 7.53 log10 cfu/cm2, and APC increased to 2.63 and 4.68 log10 cfu/cm2 for 2.0-kGy irradiated breast rolls after 14 and 28 d of storage. However, during the storage of breast rolls, L. monocytogenes grew slowly or even stopped to grow in both nonirradiated and irradiated breast rolls due to the competitive inhibition of natural flora in breast rolls. This study showed that irradiation (1.0 to 2.5 kGy) effectively reduced the number of L. monocytogenes and natural flora. However, L. monocytogenes and natural flora that survived irradiation could multiply during the 28-d storage period at 4 degrees C. Thus, additional hurdles are needed to ensure the microbial safety after low-dose irradiation.
Treatment for lymphedema of the arm--the Casley-Smith method: a noninvasive method produces continued reduction. (1998)

A comparison is drawn between the efficacy of various current treatments and their cost. This shows that this combined and conservative method of treatment should be considered before recourse to pumps or surgery. The latter seldom achieve the results of decongestive lymphatic drainage, and, in the long term, they are more expensive. Certain preventive measures may be indicated following, e.g., mastectomies. Prevention of the onset of lymphedema is of extreme importance. However, a return to as normal a lifestyle as possible by the patient is also essential. The earlier treatment begins after the onset of lymphedema, the better the prognosis for the patient. Lymphedema can and should be treated.
A Novel Nonantibiotic Gut-directed Strategy to Prevent Surgical Site Infections (2022)

A nonantibiotic phosphate-rich polymer, Pi-PEG, added to the drinking water of mice prevents SSIs and may represent a more sustainable approach in lieu of the current trend of greater sterility and the use of more powerful and broader antibiotic coverage.
Design and Evaluation of Color Separation Grating Using Rigorous Coupled Wave Analysis (2006)

In this study, we focused on a small and light grating that is capable of converting efficiently white light into only the three primary colors red, green and blue. To evaluate its diffraction characteristics properly, we performed a rigorous electromagnetic analysis based on the rigorous coupled wave analysis (RCWA). We designed the grating such that diffraction efficiency higher than 70 % and a color gamut higher than 65 % were obtained. On the basis of our numerical results, we then fabricated a grating by laser drawing and determined its color separation efficiency. The grating was etched into quartz and had a six-level surface relief, a maximum groove depth of 5.75 m, and a period of 50μEm. Furthermore, we calculated the tolerances of fabrication errors in the depth and width directions that satisfy optimal design conditions for establishing guiding principles for the accurate fabrication of multilevel color separation gratings with deep grooves.