gebhart/patrepeval huggingface dataset:
THE CONVULSIVE ACTION OF 2,5-DICARBETHOXY 3,4-DIHYDROXYTHIOPHANE (DICETOL) (1968)

Antimetabolites have been used for some time in the treatment of malignant disorders. Farber et al. (1) used folic acid antagonists and, since then, a number of antimetabolites of purines and pyrimidines have been investigated. One of the important drawbacks of all such compounds is their toxicity to host cells due to non-specicity of action. An ideal drug, therefore, would be one which would have a preferential action on tumour cells. This would be possible if tumour cells were shown to have a distinct biochemical pattern different from that of the host cells. Gadekar and Sahasrabudhe (2) have put forward evidence that there is a relative preponderence of the hexose monophosphate (HMP) pathway activity in neoplastic tissue. On the basis of this suggestion, Sahasrabudhe et al. (3) have reported 2, 5-dicarbethoxy, 3, 4-dihydroxythiophane (dicetol) to be effective in blocking the HMP pathway preferentially in tumour tissue. They have also reported anticancer properties for this compound in transplanted fibrosarcoma in Swiss mice (2-4). Since the compound showed promising results in experimental cancer, it was decided to investigate some of its pharmacological actions. Dicetol was found to produce marked pharmacodynamic effects in experimental animals. Various aspects of this problem are presented in this paper.
Managing service inventory to improve performance (2005)

Please note that gray areas reflect artwork that has been intentionally removed. The substantive content of the article appears as originally published.
Supplementary Figure 3 from Parathyroid Hormone–Related Protein Drives a CD11b<sup>+</sup>Gr1<sup>+</sup> Cell–Mediated Positive Feedback Loop to Support Prostate Cancer Growth (2023)

&lt;p&gt;PDF file - 2058K, Supplemental Fig. 3 CD11b+Gr1+ cells do not express receptors for PTHrP.&lt;/p&gt;
Tissue Preparation for Liquid Scintillation and Gamma Counting — the Counting Processes (2019)

Proper preparation of tissue for liquid scintillation or gamma counting is as important as the counting process itself and the process has to be approached in a manner commensurate with the precision and accuracy required for the measurement. Tissue samples should be as homogeneous as possible, free from fatty or connecting tissue or infiltrating foreign tissue such as tumors. The chapter provides an outline of some of the more established procedures for sample preparation and leave the sometimes necessary innovation to the investigator. Ease of solubilization is often related to particle size, and thus the use of a homogenizer to homogenize tissue samples frequently aids and often is necessary to dissolve a tissue sample completely. Tissue solubilization with quaternary ammonium compounds may be conducted in regulation liquid scintillation counting vials. Radiopharmacology has made tremendous strides based on the use of liquid beta and crystal gamma scintillation counting of biological samples.
Relationship between central venous pressure and bioimpedance vector analysis in critically ill patients (2000)

Central venous pressure values correlated with direct impedance measurements more than with total body water predictions. Whereas central venous pressure values >12 mm Hg were associated with shorter impedance vectors in 93% of patients, indicating fluid overload, central venous pressure values <3 mm Hg were associated with long impedance vectors in only 10% of patients, indicating tissue dehydration. The combined evaluation of intensive care unit patients by BIVA and central venous pressure may be useful in therapy planning, particularly in those with low central venous pressure in whom reduced, preserved, or increased tissue fluid content can be detected by BIVA.
Structure–property correlations in the new ferroelectric Bi5PbTi3O14Cl and related layered oxyhalide intergrowth phases (2002)

The crystal structure and electrophysical properties of the layered intergrowth phase Bi5PbTi3O14Cl have been studied using powder neutron diffraction, ac impedance and second harmonic generation methods. This phase adopts a structure based on a regular intergrowth of Aurivillius-like and Sillén-like blocks in the layer sequence ⋯[M2O2][M2Ti3O10][M2O2][Cl]⋯, and is therefore closely structurally related to the well-known ferroelectric Bi4Ti3O12. The phase adopts the polar orthorhombic space group P2an at temperatures below 590 °C, and transforms directly to a centrosymmetric tetragonal phase, space group P4/mmm, at that temperature. This abrupt structural phase transition is consistent with a sudden loss of SHG signal and a dielectric maximum at the same temperature. The structural features and electrophysical behaviour of this phase in relation to Bi4Ti3O12 and related layered oxides/oxyhalides are discussed.
Conditional Prior Networks for Optical Flow (2018)

Classical computation of optical flow involves generic priors (regularizers) that capture rudimentary statistics of images, but not long-range correlations or semantics. On the other hand, fully supervised methods learn the regularity in the annotated data, without explicit regularization and with the risk of overfitting. We seek to learn richer priors on the set of possible flows that are statistically compatible with an image. Once the prior is learned in a supervised fashion, one can easily learn the full map to infer optical flow directly from two or more images, without any need for (additional) supervision. We introduce a novel architecture, called Conditional Prior Network (CPN), and show how to train it to yield a conditional prior. When used in conjunction with a simple optical flow architecture, the CPN beats all variational methods and all unsupervised learning-based ones using the same data term. It performs comparably to fully supervised ones, that however are fine-tuned to a particular dataset. Our method, on the other hand, performs well even when transferred between datasets.
Assessment of Biocompatibility of Chronically Implanted Polyimide and Platinum Intrafascicular Electrodes (2007)

Longitudinal intrafascicular electrodes (LIFEs) are electrodes designed to be placed inside the peripheral nerve to improve stimulation selectivity and to increase the recording signal-to-noise ratio. We evaluated the functional and morphological effects of either Pt wire LIFEs or polyimide-based thin-film LIFEs implanted in the rat sciatic nerve for 3 mo. The newly designed thin-film LIFEs are more flexible, can be micromachined and allow placement of more active electrode sites than conventional Pt LIFEs. Functional results at 1 mo indicated an initial decline in the nerve conduction velocity and in the amplitude of muscle responses, which recovered during the following 2 mo towards normal values. Morphological results showed that both types of LIFEs induced a mild scar response and a focal but chronic inflammatory reaction, which were limited to a small area around the electrode placed in the nerve. Both types of LIFEs can be considered biocompatible and cause reversible, minimal nerve damage.
Experimental observations of the effect of gravity changes on smoldering combustion (1994)

An experimental study is conducted to determine the effect of gravity changes on the natural convection smolder characteristics of flexible polyurethane foam. Gravity, and consequently buoyancy, is expected to affect smoldering because it induces convective transport of mass and heat to and from the reaction zone. The overall objective of the work is to provide information about the potential onset of a smolder-initiated fire in a space-based facility. Experiments are conducted in an aircraft following parabolic trajectories that provide up to 25 s of low gravity (KC-135A) and up to 20 s (Learjet Model 25), with a pull-up and pull-out of approximately 2 g per parabola. Measurements are performed, during a series of parabolas, of the temperature histories of the polyurethane foam at several locations along the fuel sample interior, both for upward and downward propagation. The measurements show that gravity plays a significant role in the competition between the supply of oxidizer to, and the transfer of heat to and from, the reaction zone.
Polarization Resolved Measurement of Rayleigh Backscatter in Fiber-optic Components (2005)

Fiber-optic components, modules and assemblies for modern networking applications are becoming more complex. At the component and module level, failures such as bad splices, bends, crimps, and other non-reflective events can be extremely difficult to locate and troubleshoot. The available measurement techniques designed to identify these types of failures fall into two basic categories: optical time domain reflectometry (OTDR), and frequency domain reflectometry. Typically, OTDRs lack sufficient spatial resolution to be useful at the component and module level where one might be interested in, say, locating a bad splice in a concatenation of a dozen WDM components.
Mammalian and avian liver phosphoenolpyruvate carboxykinase. Alternate substrates and inhibition by analogues of oxaloacetate. (1990)

Phosphoenolpyruvate carboxykinase from chicken liver mitochondria and rat liver cytosol catalyzes the phosphorylation of alpha-substituted carboxylic acids such as glycolate, thioglycolate, and DL-beta-chlorolactate in reactions with absolute requirements for divalent cation activators. 31P NMR analysis of the reaction products indicates that phosphorylation occurs at the alpha-position to generate the corresponding O- or S-bridged phosphate monoesters. In addition, the enzymes catalyze the bicarbonate-dependent phosphorylation of hydroxylamine. The chicken liver enzyme also catalyze the bicarbonate-dependent phosphorylation of hydroxylamine. The chicken liver enzyme also catalyzes the bicarbonate-dependent phosphorylation of fluoride ion. The kappa cat values for these substrates are 20-1000-fold slower than the kappa cat for oxaloacetate. Pyruvate and beta-hydroxypyruvate are not phosphorylated, since the enzyme does not catalyze the enolization of these compounds. Oxalate, a structural analogue of the enolate of pyruvate, is a competitive inhibitor of phosphoenolpyruvate carboxykinase (Ki of 5 microM) in the direction of phosphoenolpyruvate formation. Oxalate is also an inhibitor of the chicken liver enzyme in the direction of oxaloacetate formation and in the decarboxylation of oxaloacetate. The chicken liver enzyme is inhibited by beta-sulfopyruvate, an isoelectronic analogue of oxaloacetate. The extensive homologies between the reactions catalyzed by phosphoenolpyruvate carboxykinase and pyruvate kinase suggest that the divalent cation activators in these reactions may have similar functions. The substrate specificity indicates that phosphoenolpyruvate carboxykinase decarboxylates oxaloacetate to form the enolate of pyruvate which is then phosphorylated by MgGTP on the enzyme.
Characterization of a Common Susceptibility Locus for Asthma-Related Traits (2004)

Susceptibility to asthma depends on variation at an unknown number of genetic loci. To identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, leading to the identification of a 133-kilobase risk-conferring segment containing two genes. One of these coded for an orphan G protein-coupled receptor named GPRA (G protein-coupled receptor for asthma susceptibility), which showed distinct distribution of protein isoforms between bronchial biopsies from healthy and asthmatic individuals. In three cohorts from Finland and Canada, single nucleotide polymorphism-tagged haplotypes associated with high serum immunoglobulin E or asthma. The murine ortholog of GPRA was up-regulated in a mouse model of ovalbumin-induced inflammation. Together, these data implicate GPRA in the pathogenesis of atopy and asthma.
Seed Production (2009)

In this chapter, we review research on tall fescue [Lolium arundinaceum (Schreb.) Darbysh.] seed production in Oregon and New Zealand, including seed certification requirements; crop establishment; agronomic and nutrient management; effects of weeds, diseases, and plant growth regulators; and harvest and post harvest managements. Establishing tall fescue in spring with a companion crop has economic benefits for seed production, while delays in fall sowing result in low seed yields at first harvest. Plant growth regulators have had a significant impact in tall fescue seed production, with seed yield increases in most trials exceeding 50% of the untreated control.
NonstableStaphylococcus aureusSmall-Colony Variants Are Induced by Low pH and Sensitized to Antimicrobial Therapy by Phagolysosomal Alkalinization (2015)

Our results show that the acidic environment favors formation of nonstable SCVs, which reflect the SCVs found in clinics. They also provide evidence that treatment with alkalinizing agents, together with antibiotics, may provide a novel translational strategy for eradicating persisting intracellular reservoirs of staphylococci. This approach may also be extended to other intracellular bacteria.
Factors influencing the lipid composition and fluidity of red cell membranes in vitro: production of red cells possessing more than two cholesterols per phospholipid (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFactors influencing the lipid composition and fluidity of red cell membranes in vitro: production of red cells possessing more than two cholesterols per phospholipidRichard A. Cooper, Mary H. Leslie, Steven Fischkoff, Meir Shinitzky, and Sanford J. ShattilCite this: Biochemistry 1978, 17, 2, 327–331Publication Date (Print):January 24, 1978Publication History Published online1 May 2002Published inissue 24 January 1978https://pubs.acs.org/doi/10.1021/bi00595a021https://doi.org/10.1021/bi00595a021research-articleACS PublicationsRequest reuse permissionsArticle Views290Altmetric-Citations165LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Humidity sensing characteristics of plasma functionalized multiwall carbon nanotube-Polyimide composite films (2008)

This paper reports the fabrication of a novel resistive-type relative humidity sensor based on plasma-functionalized MWCNT/Polyimide composite films. The relative humidity sensors shows a good linearity of 1.10 over a wide humidity range, with the sensitivity of 60Ω/%RH and response time of 10 min. The resistance increase with water adsorption of composite films with high MWCNT concentration is explained on the basis of charge transfer between the adsorbed water molecules and the CNTs.
When conflict tests your convictions (1999)

In a talk given in 1955, the distinguished physicist Isidor Rabi launched a fervent appeal for reconciliation between "the two great branches of human knowledge, the sciences and the humanities, [which] remain separate and even warring disciplines...". Later, he discussed this with C P Snow who pursued such concerns in his "Two Cultures" lecture. Rabi urged scientists to "learn to teach science in the spirit of wisdom, and in the light of the history of human thought and human effort, rather than as the geography of a universe uninhabited by mankind".
Diastereomeric 5,6-Dihydrothymidines. Preparation, Stereochemical Assignments, and MnO2 Oxidation Studies of Thymidines (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiastereomeric 5,6-Dihydrothymidines. Preparation, Stereochemical Assignments, and MnO2 Oxidation Studies of ThymidinesPalle V. P. Pragnacharyulu, Chandra Vargeese, Michael Mc Gregor, and Elie AbushanabCite this: J. Org. Chem. 1995, 60, 10, 3096–3099Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/jo00115a026https://doi.org/10.1021/jo00115a026research-articleACS PublicationsRequest reuse permissionsArticle Views305Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Design and Implement of Point-Model System Used in Reverse Engineering Based on CGAL (2009)

The software used for Reverse Engineering is becoming more and more important to designing complex industrial equipments. Aiming to this question, this paper designs and Implements one point-model system used in reverse engineering based on CGAL. In this system,unorganized point cloud is looked as input data, then the good point cloud which can express exactly topology of original sampled object is obtained through deleting noise, registering and segmenting points, at last, mesh model is output data through reconstructing, segmenting and simplifying mesh. At the same time, the result 3D model is displayed to express the apparent geometrical feature and the physical and mechanical feature is computed. By defining the format of file as input and output, the point-model system can contact with other software without interface. Through testing the point-model system in realization item, the experimental results support that the system can decrease the handwork and improve the efficiency in mesh reconstruction of point cloud.
Prise en charge des cancers solides et des hémopathies malignes du sujet âgé : l’oncogériatrie une discipline en devenir: Première partie : l’évaluation gériatrique et la prise en charge des cancers solides (2005)

Resume Propos. – La moitie des cancers apparaissent chez des patients de plus de 65 ans. A l’heure actuelle la majeure partie des etudes validant les protocoles therapeutiques est realisee sur des patients de moins de 65 ans. Nous avons effectue une revue de la litterature concernant les publications recentes decrivant les particularites de la prise en charge des patients âges atteints de cancer. Actualites et points forts. – Le but de l’oncogeriatrie est d'evaluer les ressources du patient qui vont lui permettre ou non de supporter un traitement et d'evaluer avec lui ses motivations. Parallelement, il est necessaire de connaitre les differentes options therapeutiques validees, ce que le patient peut en attendre comme benefice en confort et en survie et les risques. Cette discipline necessite une evaluation geriatrique approfondie ainsi qu’une connaissance des protocoles adaptes aux personnes âgees et des particularites de maniements des anticancereux a ces âges afin d’offrir une prise en charge globale du patient et d’approcher au mieux le rapport risque/benefice des traitements proposes. Perspectives et projets. – Compte tenu du developpement recent de l’oncogeriatrie il nous a semble utile de developper les grandes lignes de la prise en charge de cette discipline c’est-a-dire les principes de l’evaluation geriatrique et de presenter les resultats des etudes recentes sur la prise en charge des principaux cancers solides et hemopathies malignes.
Resonance Raman Spectroscopy Derived Tissue Hemoglobin Oxygen Saturation in Critically Ill and Injured Patients (2020)

R-StO2 has the potential to predict ScvO2 with high precision and might serve as a faster, safer, and noninvasive surrogate to these measures.
KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells (2008)

We report that KLF2 substantially enhances antioxidant activity of Nrf2 by increasing its nuclear localization and activation. The synergistic activity of these two transcription factors forms a major contribution to the shear stress-elicited transcriptome in endothelial cells.
Solution Structure of Human Saposin C:  pH-Dependent Interaction with Phospholipid Vesicles (2003)

Saposin C binds to membranes to activate lipid degradation in lysosomes. To get insights into saposin C's function, we have determined its three-dimensional structure by NMR and investigated its interaction with phospholipid vesicles. Saposin C adopts the saposin-fold common to other members of the family. In contrast, the electrostatic surface revealed by the NMR structure is remarkably different. We suggest that charge distribution in the protein surface can modulate membrane interaction leading to the functional diversity of this family. We find that the binding of saposin C to phospholipid vesicles is a pH-controlled reversible process. The pH dependence of this interaction is sigmoidal, with an apparent pK(a) for binding close to 5.3. The pK(a) values of many solvent-exposed Glu residues are anomalously high and close to the binding pK(a). Our NMR data are consistent with the absence of a conformational change prior to membrane binding. All this information suggests that the negatively charged electrostatic surface of saposin C needs to be partially neutralized to trigger membrane binding. We have studied the membrane-binding behavior of a mutant of saposin C designed to decrease the negative charge of the electrostatic surface. The results support our conclusion on the importance of protein surface neutralization in binding. Since saposin C is a lysosomal protein and pH gradients occur in lysosomes, we propose that lipid degradation in the lysosome could be switched on and off by saposin C's reversible binding to membranes.