gebhart/patrepeval huggingface dataset:
Cell-Specific Expression of Uptake Transporters—A Potential Approach for Cardiovascular Drug Delivery Devices (2014)

Enhanced proliferation of human coronary artery smooth muscle cells (HCASMCs) and thereby formation of neointima is one of the factors contributing to failure of coronary stents. Even if the use of drug eluting stents (DES) and thereby the local delivery of cytotoxic compounds has significantly improved the clinical outcome, unselective cytotoxic effects are assumed to hamper clinical success. Novel pharmacological approaches are required to enhance cellular selectivity of locally delivered drugs. Cell specific overexpression of a drug transporter could be used to enhance cellular accumulation and therefore cell specificity. In the herein reported study we tested the possibility of cell specific transporter expression to enhance drug effects in HCASMCs. We generated adenoviral constructs to overexpress the organic cation transporter 1 (OCT1) under control of the promoter of SM22α, which had been previously reported as muscle cell specific gene. First the activity of the SM22α-promoter was assessed in various cell types supporting the notion of muscle cell specificity. Subsequently, the activity of the transporter was compared in infected HCAECs and HCASMCs revealing enhanced accumulation of substrate drugs in HCASMCs in presence of the SM22α-promoter. Testing the hypothesis that this kind of targeting might serve as a mechanism for cell-specific drug effects, we investigated the impact on paclitaxel treatment in HCASMC and HCAECs, showing significantly increased antiproliferative activity of this substrate drug on muscle cells. Taken together, our findings suggest that cell-specific expression of transport proteins serves as mechanism governing the uptake of cytotoxic compounds for a selective impact on targeted cells.
Age-related changes in the local intestinal renin-angiotensin system in normotensive and spontaneously hypertensive rats. (2019)

Local renin-angiotensin systems (RAS) are found in many tissues. The main physiological effects of RAS are driven by the balance between two pathways: the angiotensin-converting enzyme I - angiotensin II receptor type 1 (ACE1-AT1R) axis and the angiotensin-converting enzyme 2 - Mas-receptor (ACE2-MAS) axis. The local intestinal RAS functions both as a paracrine regulator and as a regulator of inflammation. The expression of local RAS is known to change with age in many tissues, but age-related changes in the intestinal RAS have not been studied comprehensively. The present study characterized age-related changes in two main pathways of local RAS in the jejunum and colon of young and adult rats, in normotensive and hypertensive strains. The main finding was that 33-week-old rats exhibit an increased ratio of ACE1/ACE2 activities and protein quantity ratios compared to young rats. As the relationship of ACE1 and ACE2 mediated pathways drives the total physiological effects of RAS, the results indicate that the function of intestinal RAS changes with age. It is possible that age-related increase in ACE1-AT1R axis introduces more pro-inflammatory and fibrogenic conditions in the intestine.
Discovering and Validating Neoantigens by Mass Spectrometry-based Immunopeptidomics and Deep Learning (2022)

Abstract Neoantigens are promising targets for cancer immunotherapy but their discovery remains challenging, mainly due to the sensitivity of current technologies to detect them and the specificity of our immune system to recognize them. In this study, we addressed both of those problems and proposed a new approach for neoantigen identification and validation from mass spectrometry (MS) based immunopeptidomics. In particular, we developed DeepNovo Peptidome, a de novo sequencing-based search engine that was optimized for HLA peptide identification, especially non-canonical HLA peptides. We also developed DeepSelf, a personalized model for immunogenicity prediction based on the central tolerance of T cells, which could be used to select candidate neoantigens from non-canonical HLA peptides. Both tools were built on deep learning models that were trained specifically for HLA peptides and for the immunopeptidome of each individual patient. To demonstrate their applications, we presented a new MS-based immunopeptidomics study of native tumor tissues from five patients with cervical cancer. We applied DeepNovo Peptidome and DeepSelf to identify and prioritize candidate neoantigens, and then performed in vitro validation of autologous neoantigen-specific T cell responses to confirm our results. Our MS-based de novo sequencing approach does not depend on prior knowledge of genome, transcriptome, or proteome information. Thus, it provides an unbiased solution to discover neoantigens from any sources.
Colpocleisis: A Survey of Current Practice Patterns (2017)

There is variation in the current practice of colpocleisis in the United States. LeFort colpocleisis is most commonly performed, and routine hysterectomy is uncommon. Two thirds of surgeons evaluate the endometrium prior to surgery. Concomitant anti-incontinence procedures appear to be standard.
The Lateral Decubitus Approach for Complex Proximal Femur Fractures (2011)

Summary: Unstable intertrochanteric or subtrochanteric fractures with significant proximal or distal extension or comminution are often a challenge for achieving stable fixation. In recent years, locked proximal femoral plates have been developed that aid fixation of these complex fractures often permitting the biological advantages of minimal contact or minimally invasive application. Although previously described with success using a standard lateral approach in the supine position, we describe a lateral decubitus position for the locked plating of proximal femur fractures. We have found that lateral positioning neutralizes the gravitational forces acting on the bone and soft tissues, facilitating reduction and exposure while continuing to be compatible with intraoperative image intensification. We present lateral positioning as a technical trick for anatomic and stable reduction of complex proximal femur fractures with proximal femoral locking plates and present a series of 10 cases that were treated with this combination of approach and internal fixation.
Preparation of Ginsenoside Rg3 and Protection against H2O2-Induced Oxidative Stress in Human Neuroblastoma SK-N-SH Cells (2014)

The aim of this study is to evaluate the protection of ginsenoside Rg3 against oxidative stress in human neuroblastoma SK-N-SH cells. 20(R)-ginsenoside Rg3 (20(R)-Rg3) and 20(S)-ginsenoside Rg3 (20(S)-Rg3) were prepared by the method of chemical degradation and column chromatography, and the structure of the two compounds was characterized by 1 H-NMR and 13 C-NMR spectroscopy. MTT assay and LDH leakage assay were used to determine the cell viability and the oxidative stress cellular model was established by means of H 2 O 2 (600 μ M for 4 h). We also investigated the changes of intracellular MDA content, SOD activity, and ROS formation after the treatment of ginsenoside Rg3 for 20 h. The results indicated that both 20 (R)-Rg3 and 20 (S)-Rg3 had obvious protection against H 2 O 2 -induced oxidative stress in SK-N-SH cells. Moreover, 20(R)-Rg3 exhibited better antioxidant activity than 20(S)-Rg3 in vitro . These findings are expected to provide some implication for further research and application of ginsenoside Rg3 in neuroprotection.
ChemInform Abstract: Chiral Phosphine Oxides in Present‐Day Organocatalysis (2010)

Abstract Review: 33 refs.
Potential probiotic properties of lactic acid bacteria isolated from the intestinal mucosa of healthy piglets (2017)

In the present study, the probiotic properties of 52 lactic acid bacteria strains, isolated from the intestinal mucosa of 60-day-old healthy piglets, were evaluated in vitro in order to acquire probiotics of potential application. Based on acidic and bile salt resistance, 11 lactic acid bacteria strains were selected, among which 1 was identified as Pediococcus acidilactici, 3 as Enterococcus faecium, 3 as Lactobacillus rhamnosus, 2 as Lactobacillus brevis, and 2 as Lactobacillus plantarum by 16S rRNA gene sequencing. All selected strains were further investigated for transit tolerance in simulated upper gastrointestinal tract, for adhesion capacity to swine intestinal epithelial cells J2 (IPEC-J2), for cell surface characteristics including hydrophobicity, co-aggregation and auto-aggregation, and for antimicrobial activities. Moreover, hemolytic, bile salt hydrolase and biogenic amine-producing abilities were investigated for safety assessment. Two E. faecium (WEI-9 and WEI-10) and one L. plantarum (WEI-51) exhibited good simulated upper gastrointestinal tract tolerance, and showed high auto-aggregation and co-aggregation with Escherichia coli 1570. The strains WEI-9 and WEI-10 demonstrated the highest adherence capacity. The 11 selected strains mentioned above exhibited strong antimicrobial activity against E. coli CVCC1570, Staphylococcus aureus CVCC1882 and Salmonella pullorum AS1.1859. None of the 11 selected strains, except WEI-9 and WEI-33, exhibited bile salt hydrolase, hemolytic or biogenic amine-producing abilities. This work showed that the E. faecium WEI-10 and L. plantarum WEI-51were found to have the probiotic properties required for use as potential probiotics in animal feed supplements.
INTEGRATED MONITORING HARDWARE DEVELOPMENTS AT LOS ALAMOS (1999)

The hardware of the integrated monitoring system supports a family of instruments having a common internal architecture and firmware. Instruments can be easily configured from application-specific personality boards combined with common master-processor and high- and low-voltage power supply boards, and basic operating firmware. The instruments are designed to function autonomously to survive power and communication outages and to adapt to changing conditions. The personality boards allow measurement of gross gammas and neutrons, neutron coincidence and multiplicity, and gamma spectra. In addition, the Intelligent Local Node (ILON) provides a moderate-bandwidth network to tie together instruments, sensors, and computers.
Microwave Photon Detector in Circuit QED (2009)

In this Letter we design a metamaterial composed of discrete superconducting elements that implements a high-efficiency microwave photon detector. Our design consists of a microwave guide coupled to an array of metastable quantum circuits, whose internal states are irreversibly changed due to the absorption of photons. This proposal can be widely applied to different physical systems and can be generalized to implement a microwave photon counter.
The dynamics of functional connectivity in neocortical focal epilepsy (2017)

Focal epilepsy is characterised by paroxysmal events, reflecting changes in underlying local brain networks. To capture brain network activity at the maximal temporal resolution of the acquired functional magnetic resonance imaging (fMRI) data, we have previously developed a novel analysis framework called Dynamic Regional Phase Synchrony (DRePS). DRePS measures instantaneous mean phase coherence within neighbourhoods of brain voxels. We use it here to examine how the dynamics of the functional connections of regional brain networks are altered in neocortical focal epilepsy. Using task-free fMRI data from 21 subjects with focal epilepsy and 21 healthy controls, we calculated the power spectral density of DRePS, which is a measure of signal variability in local connectivity estimates. Whole-brain averaged power spectral density of DRePS, or signal variability of local connectivity, was significantly higher in epilepsy subjects compared to healthy controls. Maximal increase in DRePS spectral power was seen in bilateral inferior frontal cortices, ipsilateral mid-cingulate gyrus, superior temporal gyrus, caudate head, and contralateral cerebellum. Our results provide further evidence of common brain abnormalities across people with focal epilepsy. We postulate that dynamic changes in specific cortical brain areas may help maintain brain function in the presence of pathological epileptiform network activity in neocortical focal epilepsy.
Sulfur Vulcanization of Simple Model Olefins Part III: Vulcanization of 2,3-Dimethyl-2-Butene in the Presence of Different Metal Complexes (1994)

Abstract The mechanism of the sulfur vulcanization of rubber was studied by using 2,3-dimethyl-2-butene (C 6 H 12 ) as a simple, low-molecular model alkene. Only equivalent allylic positions are present in this alkene. Treating C 6 H 12 with a mixture of ZnO, S 8 and the accelerator tetramethylthiuramdisulfide at 140°C yields a mixture of addition products (C 6 H 11 —S n —C 6 H 11 ) . Similar reactions in the presence of various metal oxides instead of zinc oxide show poor vulcanization results. Experiments with various metal dithiocarbamate complexes show a reactivity towards vulcanization in the following sequence: Zn(detc) 2 &gt;Cd(detc) 2 &gt;Cu(detc) 2 &gt;Pb(detc) 2 &gt;Zn(dmtc) 2 &gt;Ni(detc) 2 &gt;Cu(dmtc) 2 .
Parallel Epidemics of Community-Associated Methicillin-ResistantStaphylococcus aureusUSA300 Infection in North and South America (2015)

Our results reveal the existence of 2 parallel USA300 epidemics that shared a recent common ancestor. The simultaneous rapid dissemination of these 2 epidemic clades suggests the presence of shared, potentially convergent adaptations that enhance fitness and ability to spread.
Rhodium(III)-Cyclometalated-Imine Complexes:  Solution Behavior and Reactivity with Molecular Hydrogen (2005)

Acetone solutions of cis,trans,cis-[Rh(H)2(PPh3)2(acetone)2]PF6 and cis-[Rh(PPh3)2(acetone)2]PF6 react with the imines RNCR‘(R‘ ‘), where R = PhCH2, Ph, or C6H11; R‘ = H or Me; and R‘ ‘ = Ph or p-OMe-C6H4, to form orthometalated complexes exemplified by [Rh(H){RNCR‘(o-C6H4)}(PPh3)2(acetone)]PF6 that are generally characterized spectroscopically, and in one case (where R = PhCH2, R‘ = Me, and R‘ ‘ = p-OMe-C6H4) by X-ray crystallography. These complexes maintain their integrity in acetone solution and show no reaction toward 1 atm H2 at ambient conditions. In MeOH, the complexes in which R‘ = Me simply change to the corresponding MeOH derivative, but when R‘ = H they are partially converted to the non-orthometalated, η1-N-imine species [Rh(PPh3)2(RNCHR‘ ‘)(MeOH)]PF6 (I), and in MeOH, stoichiometric hydrogenation of the imine to the corresponding amine occurs via I. We have shown recently (Inorg. Chem. 2004, 43, 4820) that the catalyzed hydrogenation of PhCH2NC(H)Ph to dibenzylamine using cis,trans,cis-[Rh(H)2(PPh3)2(MeOH)2]PF6 as catalyst precursor in MeOH proceeds via a cationic Rh-(η1-N-imine)(amine) intermediate (II), analogous to I but with the MeOH replaced by the amine that is formed via hydrolysis of the imine by the presence of adventitious water. Intermediate I (R = PhCH2, R‘ ‘ = Ph) is shown to be somewhat less active than II toward H2, but both intermediates provide viable pathways for hydrogenation of the imine. The orthometalated imine-amine complex [Rh(H){PhCH2NC(Me)(o-C6H4)}(PPh3)2(NH2CH2Ph)]PF6, where the benzylamine comes from imine hydrolysis, is also isolated and characterized crystallographically.
Transparent ultraviolet‐barrier coatings (1971)

Abstract A number of phenyl polyesters have been synthesized to furnish molecules whose backbones rearrange under ultraviolet irradiation to an o ‐hydroxybenzophenone structure. This photochemical Fries rearrangement produces ultraviolet opacity in the irradiated film while maintaining visual transparency. Thin coatings of these polyesters completely protect substrates ordinarily sensitive to ultraviolet light. Spectroscopic analysis of various rearranged films and coatings clearly shows that the o ‐hydroxybenzophenone polymer formed is concentrated at the irradiated surface of the original polyester coating as a “skin”. Such a skin, formed in situ during the irradiation, functions to protect both the original polyester coating as well as the coated substrate from degradation by ultraviolet irradiation. Furthermore, a significant “healing” mechanism appears inherent in these coatings, for as the exposed skin ultimately degrades under extended ultraviolet irradiation, more of the underlying polyester layer apparently rearranges to compensate for the loss. Thus the clear coating functions both as a protective skin and a rearrangeable reservoir. Modified structures of the polyesters have been prepared which possess, in addition to their protective film properties, a useful solubility spectrum and a good solution shelf life.
Design and Performance of Cryogenically Coolable Ultra Low Noise L-Band Amplifier (1992)

The design, realization and measurement of an ultra low-noise, cryogenically-coolable, L-band amplifier for radio astronomy applications are described. The amplifier exhibits 3 K (0.045 dB N.F.) average noise temperature over 600 MHz. bandwith with 36 dB of gain at ambient temperature of 12.5 K and 2 K average noise at physical temperature of 4.2 K. Excellent agreement between measured and predicted results verifies the validity of a recent published wideband model of a FET for L-band frequencies.
Numerical Simulation and Experimental Study of the Tube Receiver's Performance of Solar Thermal Power Tower (2014)

Abstract A water-vapor tube receiver is a significant component in the solar thermal power tower plant. However, the tube flow performance is much different from others. Because semi-circumference of the tube is heated with an uneven heat flux, which is into a Gaussian distribution in this paper, and the other semi-circumference is insulated. A 5kW- Xe-arc lamp was used to simulate a solar light source. In this study, the effect of different entrance velocity on the flow performance and thermal efficiency of the tube receiver are investigated with numerical and experimental methods. The results of experiment and simulation agree well. The results show that the temperature distribution of water and tube wall are very uneven both in the axial and radial directions. The thermal efficiency of the tube receiver increases with the increase of entrance velocity.
New statistical symmetries of the multi-point equations and its importance for turbulent scaling laws (2010)

We presently show that the infinite set of multi-point correlation equations, which are direct statistical consequences of the Navier-Stokes equations, admit a rather large set of Lie symmetry groups. This set is considerable extended compared to the set of groups which are implied from the original set of equations of fluid mechanics. Specifically a new scaling group and translational groups of the correlation vectors and all independent variables have been discovered. These new statistical groups have important consequences on our understanding of turbulent scaling laws to be exemplarily revealed by two examples. Firstly, one of the key foundations of statistical turbulence theory is the universal law of the wall with its essential ingredient is the logarithmic law. We demonstrate that the log-law fundamentally relies on one of the new translational groups. Second, we demonstrate that the recently discovered exponential decay law of isotropic turbulence generated by fractal grids is only admissible with the new statistical scaling symmetry. It may not be borne from the two classical scaling groups implied by the fundamental equations of fluid motion and which has dictated our understanding of turbulence decay since the early thirties implicated by the von-Kármán-Howarth equation.
XML query forms (XQForms) (2001)

Article XML query forms (XQForms): declarative specification of XML query interfaces Share on Authors: Michalis Petropoulos Dept. of Computer Science and Engineering, University of California, San Diego Dept. of Computer Science and Engineering, University of California, San DiegoView Profile , Vasilis Vassalos Information Systems Dept., New York University and Enosys Markets, Inc Information Systems Dept., New York University and Enosys Markets, IncView Profile , Yannis Papakonstantinou Dept. of Computer Science and Engineering, University of California, San Diego and Enosys Markets, Inc Dept. of Computer Science and Engineering, University of California, San Diego and Enosys Markets, IncView Profile Authors Info & Claims WWW '01: Proceedings of the 10th international conference on World Wide WebMay 2001 Pages 642–651https://doi.org/10.1145/371920.372170Online:01 April 2001Publication History 17citation517DownloadsMetricsTotal Citations17Total Downloads517Last 12 Months4Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A Systematic Approach to Evaluating and Benchmarking Robotic Hands - The FFP Index (2018)

The evaluation of robotic hands is a subjectively biased, complex process. The fields pertaining to robotic hands are human-centric in nature, making human hands a good standard for benchmark comparisons of robotic hands. To achieve this, we propose a new evaluation index, where we evaluate robotic hands on three fronts: their form, features and performance. An evaluation on how anthropomorphic robotic hands are in basic mobility, and appearance constitutes the ``Form'', while features that can be read, changed and actuated for effective control of robotic hands constitutes the ``Features''. We derived these key features from an extensive analysis of robotic hands in literature. Finally, the robotic hands carry out a series of tasks that evaluate their ``Performance''. An individual score for each category is drawn and we carry out a three-pronged analysis. We also propose an additional feature in the form of price to provide context when analysing multiple hands.
The 3D SEG Salt Model - Dreams and Reality (1994)

Wave-equation modeling of 3-D seismic data in non-trivial geologic models is a non-trivial computational problem. While ray-tracing and other simple methods offer advantages in speed and/or simplicity, we are drawn toward using as complete a physical description of wave phenomena as we can aspire to. Typically this means full wave equation finite-difference or finite-element methods. If we are interested in P-wave or "acoustic" data, we have the choice of modeling a zero-offset section directly, or modeling shot records which would simulate a typical field experiment; one can also model other experiments, hypothetical or real, such as plane wave or conical wave sources. From the point of view ofthe numerical simulation, the goal is to get as many wavelengths of some specified frequency into the computational model as possible.
Adjuvant-induced arthritis in the temporomandibular joint of rats (1983)

When Lewis rats were immunized by intradermal injection into the parietal scalp rather than into the footpad with mycobacterial delipidated cells in squalene, arthritis could be produced in the temporomandibular joint (TMJ) with a maximum incidence of 60%, accompanied by systemic polyarthritis. Other methods of immunization including intradermal injection into the tail, posterior cervical region, or intra-inguinal lymph nodes did not induce arthritis in the TMJ. A combination of this inoculation and hemiocclusal loss markedly increased the incidence of arthritis in the TMJ. This arthritis in the TMJ was, however, milder than that in other joints and was apparent only histologically. The group given intradermal injection of adjuvants into the parietal scalp showed definite suppression of body weight gain. Since the method of intradermal injection into the parietal scalp can induce a high incidence of arthritis in the TMJ, our study presents a unique experimental model for study of arthritis in the TMJ.