gebhart/patrepeval huggingface dataset:
PHM Features for Large Circuit Boards to Be Implemented Into Electric Drivetrain Applications (2020)

Abstract Canary structures being used as early warning indicators represent an important tool for condition and health monitoring of electronic components and systems. In this paper, printed circuit boards with canary structures based on SMD 2512 ceramic chip resistors with reduced solder pad sizes were studied. Focus of these investigations was set on thermo-mechanical and mechanical stresses caused by passive thermal cycling as well as by vibrational loads. For this purpose, experimental methods such as deformation analysis and accelerated ageing tests as well as finite element based methods were applied. In addition, an outlook on the implementation of these canary structures into dual inverter electronic control boards for electrical powertrain applications will be given.
Rapid isolation of plasma membranes in high yield from cultured fibroblasts (1977)

1. A method was developed which allows the rapid preparation of pure plasma membranes in high yield from cultured fibroblasts. 2. Cells are lysed in hypo-osmotic borate/EDTA and, after differential centrifugation, the membranes collected by centrifugation on a sucrose barrier. 3. Electron microscopy of the isolated material shows large membrane vesicles essentially free from contaminating organelles. 4. There is no detectable activity of the endoplasmic-reticulum enzyme marker, NADH2--lipoamide oxidoreductase (EC 1.6.4.3), and that of succinate dehydrogenase (EC 1.3.99.1), a marker for mitochondria, is substantially decreased. Chemical compositions are in good agreement with previous observations. 5. This study confirms the usefulness of applied isotopic markers for isolating plasma membranes.
Lignin-oxidizing and xylan-hydrolyzing Vibrio involved in the mineralization of plant detritus in the continental slope (2022)

A large amount of terrigenous organic matter (TOM) is constantly transported to the deep sea. However, relatively little is known about the microbial mineralization of TOM therein. Our recent in situ enrichment experiments revealed that Vibrio is especially enriched as one of the predominant taxa in the cultures amended with natural plant materials in the deep sea. Yet their role in the mineralization of plant-derived TOM in the deep sea remains largely unknown. Here we isolated Vibrio strains representing dominant members of the enrichments and verified their potential to degrade lignin and xylan. The isolated strains were closely related to Vibrio harveyi, V. alginolyticus, V. diabolicus, and V. parahaemolyticus. Extracellular enzyme assays, and genome and transcriptome analyses revealed diverse peroxidases, including lignin peroxidase (LiP), catalase-peroxidase (KatG), and decolorizing peroxidase (DyP), which played an important role in the depolymerization and oxidation of lignin. Superoxide dismutase was found to likely promote lignin oxidation by supplying H<sub>2</sub>O<sub>2</sub> to LiP, DyP, and KatG. Interestingly, these deep-sea Vibrio strains could oxidize lignin and hydrolyze xylan not only through aerobic pathway, but also through anaerobic pathway. Genome analysis revealed multiple anaerobic respiratory mechanisms, including the reductions of nitrate, arsenate, tetrathionate, and dimethyl sulfoxide. The strains showed the potential to anaerobically reduce sulfite and metal oxides of iron and manganese, in contrast the non-deep-sea Vibrio strains were not retrieved of genes involved in reduction of metal oxides. This is the first report about the lignin oxidation mechanisms in Vibrio and their role in TOM mineralization in anoxic and oxic environments of the marginal sea.
Performance Metrics for Freeway Sensor (2004)

Performance measures play a critical role in the operation of Intelligent Transportation Systems (ITS), because they provide feedback to the operators regarding system operations and efficiency. Traffic management systems use archived data, provided by various sensors, as a basis for describing normal conditions and predicting traffic conditions that may be expected at a particular time and place in the highway system. However, data quality is one of the principal concerns of archived ITS data users for the following reasons: 1) Manual inspection techniques are unable to detect significant errors because of the large volume of ITS data; 2) Only minimal error detection can be performed as the data is being collected; 3) Sensors may only fail intermittently and not affect long-term averages; 4) Sensor failures may be masked by congestion or incidents. This project examined several quality control issues on one of the nation’s busiest sections of Interstate, the Borman expressway (I-80/94). Various tests such as speed and volume comparisons, data availability and average effective vehicle length test were developed and applied, revealing significant inconsistency in data quality provided by different detection technologies. Results that document these problems are presented in this study and causes of non-random changes are identified. Finally, several recommendations for improving construction and configuration procedures are proposed. Several simple performance metrics are also documented that transportation agencies can use to assess the quality of traffic data and sustain that quality over time.
Abstract 1784: IL-7R targeting therapy for immunoregulation and overcoming steroid resistance in cancer and autoimmune disease (2018)

Abstract The occurrence of autoimmune reactions caused by immune checkpoint blockade in the treatment of cancer indicates the importance of the cross-disciplinary study of malignancy and autoimmune disease. Meanwhile, although steroids have been commonly used for the treatment of malignancies and immune diseases, steroid resistance is a serious prognosis factor and remains an unsolved problem. IL-7R signaling, which physiologically regulates lymphocyte growth and survival, including antigen-responsive T lymphocyte selection, has been implicated in the development of malignancies and autoimmune diseases. However, the biological significance of IL-7R-signaling in steroid treatment is poorly understood. Here, we identified the relationship between unique IL-7R-signaling and steroid-resistance in lymphoid malignancy and demonstrated the presence of steroid-resistant IL-7R-positive lymphocytes in a mouse bone marrow and spleen or in a mouse model of autoimmune arthritis following steroid treatment. We further showed that an anti-IL-7R-antibody conjugated with SN-38 (A7R-ADC-SN-38) has strong anti-tumor effects against both parent and steroid-resistant malignant cells. Although A7R-ADC-SN-38 efficiently eliminated IL-7R-positive cells, IL-7R-negative mature lymphocytes were preserved. Furthermore, inflammation in the mouse autoimmune arthritis model was suppressed to a greater extent by A7R-ADC conjugated to MMAE than by A7R-ADC-SN-38. Strong and specific elimination of enhanced IL-7R-positive cells, a common pathogenesis of both lymphoid malignancy and autoimmune disease, might prevent the development of malignancy or autoimmune disease in high-risk patients. Thus, the use of A7R-ADC may be a promising strategy for the immunoregulation of both malignancy and autoimmune disease and may serve as a new option to steroid therapy. Thus, A7R-ADC may be a promising strategy to treat malignancies and autoimmune diseases and may serve as a novel alternative to steroid therapy. Thus, A7R-ADC may be a promising strategy to treat malignancies and autoimmune diseases and may serve as a novel alternative to steroid therapy. We have evaluated the effectiveness of A7R-ADC in the treatment of other autoimmune or inflammatory diseases involving IL-7R signaling in a preclinical setting for general use. In addition, IL-7R metastatic solid tumors which acquired Il-7R-dependent homing ability of lymphocytes to be spread into many organs may also be promising therapeutic targets of A7R-ADC. We are proceeding the study to advance A7R-ADC for clinical use in both cancer and autoimmune disease Citation Format: Masahiro Yasunaga, Shino Manabe, Yasuhiro Matsumura. IL-7R targeting therapy for immunoregulation and overcoming steroid resistance in cancer and autoimmune disease [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1784.
Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistancein vivoinCandida albicansorchestrated by multiple genetic alterations (2015)

C. albicans demonstrates a diverse capacity to adapt to antifungal exposure. Potentially novel resistance-inducing mutations in TAC1, ERG11 and ERG2 require independent validation.
The Effect of Cholesterol on Membrane Binding and Self-Assembly of Collagen Fibrils (2020)

Collagen is a skeleton of native extracellular matrix (ECM) that is known to provide mechanical and structural stability. In an attempt to develop a new connective cellular model with the surrounding ECM without further experimental complications, such as the reconstitution of ECM receptors, we designed the experiments and discovered that the fibrillogenesis of membrane-bound collagen is not spontaneous as it is in the form of free collagen in bulk solution. The confocal microscopic results suggest that cholesterol is a crucial component that facilitates the fibril formation on the membrane surface. <i>In situ</i> X-ray and neutron reflectivity on Langmuir monolayer and solid-supported lipid bilayer models, respectively, reveal two features of cholesterol effects on the collagen fibril formation. Mainly, cholesterol increases the lateral lipid headgroup separation on the membrane surface, which promotes the association degree of collagen monomers. It also enhances the elastic modulus of the membrane to impede membrane filtration by the collagen assemblies.
A convenient route to internally phosphane-stabilized aryltriborane(7) compounds (2018)

The biphenylene derived triborane(7) derivatives 7 featuring an internal phosphane donor group can readily be prepared from the respective in situ generated aryllithium compound with excess BH3·SMe2. The internal donor group assisted assembly procedure was also applied to the synthesis of the phenylene bonded triborane(7) compound 11. These aryl-triborane(7) systems can further react with HB(C6F5)2 to give the doubly C6F5 functionalized derivatives 12 and 13. The products were characterized spectroscopically and by X-ray diffraction.
Evaluation of placental syndecan‐1 expression in early pregnancy as a predictive fetal factor for pregnancy outcome (2012)

Placental syndecan-1 expression is associated with premature birth and fetal growth.
Adsorption—Desorption Isotherm Studies of Catalysts. I. Supported Catalysts in the Powder and Pellet Forms (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorption—Desorption Isotherm Studies of Catalysts. I. Supported Catalysts in the Powder and Pellet FormsHerman E. Ries Jr., Robert A. Van Nordstrand, Marvin F. L. Johnson, and Herman O. BauermeisterCite this: J. Am. Chem. Soc. 1945, 67, 8, 1242–1245Publication Date (Print):August 1, 1945Publication History Published online1 May 2002Published inissue 1 August 1945https://pubs.acs.org/doi/10.1021/ja01224a004https://doi.org/10.1021/ja01224a004research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Distribution of cyclocytidine in tissues. (1975)

The distribution and changes of concentration of cyclocytidine in tissues with time were quantitatively examined after intravenous injection or oral administration. Localized distribution of the compound in tissues was confirmed quantitatively and retention of the compound in most of the tissues tested was found out. Whereas, aracytidine distributed uniformly in tissues and elimination rate of the compound from tissues was similar in each other. After oral administration, cyclocytidine distributed in various tissues at very low levels.
Abstract 12411: Prognostic Value of Cardiovascular Magnetic Resonance-Derived Indices of Right Ventriculo-Arterial Coupling and Internal Mechanical Work in Pulmonary Hypertension (2014)

Objectives: External cardiac work performed is represented by the area within the ejection loop (P-V) and correlates poorly with the heart’s total energy demands until the internal work component is added. Further, the ratio of the arterial elastance (E a ) to the ventricular end-systolic elastance (E max ) is a measure of ventriculo-arterial coupling. We investigated the impact of both indices of right ventricular (RV) performance on outcome in patients with pulmonary hypertension (PH). Methods: Cardiac magnetic resonance (CMR) studies of a retrospective consecutive cohort of 115 PH pts (61±14 yrs) were examined for RV volumetrics, functional indices and the presence of RV late gadolinium enhancement (LGE) from 2008-2014. Right heart cath (RHC) parameters were included in the analysis (performed within 1±1.5 mo of CMR) as was 3D RV mass and RVEF. The E a /E max ratio was derived in part as RV end-systolic volume (ESV)/RV stroke volume. Internal mechanical work was estimated as RVESV*(RV-ES pressure- RV-ED pressure). Patients were followed up to 5 yrs. Results: During follow-up, 42/115 (37%) pts had a MACE. On a multivariable logistic regression analysis, the strongest predictor of MACE was the internal RV mechanical work followed in order by E a /E max versus mean pulmonary artery pressure, RV mass, RV EF, and RV LGE. The strongest predictors of time to MACE were the RV internal mechanical work (χ 2 =10.8) and E a /E max ratio (χ 2 =9.2). Kaplan-Meier analysis of time to MACE for quartiles of RV internal mechanical work and E a /E max are shown in Figure 1A &amp; B. Conclusions: Higher RV internal mechanical work and E a /E max are both markers for worsening prognosis in PH patients; E a /E max having the added advantage of being an entirely non-invasive CMR derivation and statistically equivalent. Both metrics were superior to standard clinical metrics including RV LGE, RVEF, PA pressure and RV mass and for the first time address integrated cardio-pulmonary physiology as early markers for MACE.
Music Therapy Increases Comfort and Reduces Pain in Patients Recovering From Spine Surgery. (2017)

The treatment of pain continues to gain in saliency as a component of defining best practice in medical care. Music therapy is an integrative treatment modality that impacts patient outcomes in the treatment of spinal pain. At Mount Sinai Beth Israel, we conducted a mixed-methods study addressing the effects of music therapy interventions on the recovery of patients after spine surgery. The study combined standard medical approaches and integrative music therapy. Sixty patients (35 female, 25 male) ranging in age from 40 to 55 years underwent anterior, posterior, or anterior-posterior spinal fusion and were randomly assigned to either music therapy plus standard care (medical and nursing care with scheduled pharmacologic pain intervention) or standard care only. Measurements for both groups were completed before and after the intervention. Music therapy involved the use of patient-preferred live music that supported tension release/relaxation through incentive-based clinical improvisation, singing, and/or rhythmic drumming or through active visualization supported by live music that encompasses tension resolution. The control and music groups showed significant differences in degree and direction of change in the visual analog scale (VAS) pain ratings from before to after intervention (P = .01). VAS pain levels increased slightly in the control group (to 5.87 from 5.20) but decreased by more than 1 point in the music group (to 5.09 from 6.20). The control and music therapy groups did not differ in the rate of change in scores on Hospital Anxiety and Depression Scale (HADS) Anxiety (P = .62), HADS Depression (P = .85), or Tampa Scale for Kinesiophobia (P = .93). Both groups had slight increases in HADS Anxiety, comparable decreases in HADS Depression, and minimal changes in fear-related movement (Tampa scale).
SURFACE SELECTION RULES FOR SERS: CALCULATIONS AND APPLICATION TO THE SERS SPECTRUM OF PHTHALAZINE ON Ag (1984)

Author Institution: Department of Chemistry and Erindale College, University of Toronto
Characterization of an Unusual New Agrobacterium tumefaciens Strain from Chrysanthemum morifolium Ram (1991)

We characterized five isolates of Agrobacterium tumefaciens from naturally occurring galls on Chrysanthemum morifolium. The isolates are similar, possibly identical, members of a single strain of A. tumefaciens that we designate Chry5. The strain is a biotype I, as indicated by its response to both newly described and traditional biotype tests. Chry5 produces tumors on at least 10 plant species. It is unusual in its ability to form efficiently large tumors on soybean (Glycine max), a species normally refractory to transformation. Chry5 is unable to utilize octopine or mannopine as a carbon source. Although Chry5 can catabolize a single isomer each of nopaline and succinamopine, it differs from other known nopaline and succinamopine strains in its insensitivity to agrocin 84. This pattern of opine catabolism is unique among Agrobacterium strains examined to date. All five isolates of Chry5 contain at least two plasmids, one of which shares homology with pTiB6.
HWT vis-a-vis chemical treatments for controlling gladiolus corm rot caused by Fusarium oxysporum f. sp. Gladioli (2001)

HWT of gladiolus conns (50°C; 30 min) was not consistently found to give good control of rot caused by Fusarium oxysporum f. sp. gladioli; Rather, it often had adverse effect on corm sprouting and plant growth. Chemical treatment of Emisan-6 (0.2%, 10 min dip) was found to be significantly better than HWT. It is concluded that there is no need to go in for HWT when more effective chemical treatments exist. The chemical treatments are, moreover, easy to apply and do not suffer from the drawback of precisely controlling the temperature.
The Influence of Calcitriol and Tacalcitol on Proliferation of Fibroblasts Cultured from Nasal Polyps* Badanie wpływu kalcitriolu i tacalcitolu na proliferację fibroblastów otrzymanych z polipów nosowych (2007)

Background. Recurrent polyposis resulting in the necessity of repeated polypectomy encouraged the search for new pharmacological therapeutic methods. At present, locally acting glycocorticosteroids have the greatest value in the treatment of nasal polyposis. Polyp growth is connected with inflammation and the proliferation of fibroblasts. Objectives. An evaluation of the influence of calcitriol and tacalcitol on the proliferation of fibroblasts extracted from nasal polyps. Material and Methods. The study involved 14 tissue samples of nasal polyps sampled during polypectomies. Testing was performed on the polyps cells after the sixth passage after the primary culture was established. Three days after the culture was started, nutrient medium without additional serum was added to the cells and after a fur− ther 24 hours the medium was replaced by nutrient medium with tacalcitol and calcitriol in defined concentrations. Results. Tacalcitiol and calcitriol in vitro decreased the proliferation of fibroblasts extracted from nasal polyps. Inhibition was most effective at concentrations of 10 –4 M and 10 –3 M. Conclusions. Experimental data suggest tacalcitiol to be more effective at the same concentration. This study may indicate the direction of further investigations in the potential pharmacological treatment of nasal polyps (Adv Clin Exp Med 2007, 16, 2, 213–219).
Role of Interferon -γ-Inducible Protein (IP)-10/ (IP-10/CXCL10) in Ulcerative Colitis; A Review of the Present Status (2011)

Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease (IBD) affecting the colonic mucosa; it is of unknown etiology UC clinically displays bloody diarrhea, abdominal pain and weight loss, and often leads to a severe outcome since the therapeutic approaches, including corticosteroid and 5-aminosalicylic acid, are not always successful in inducing long-term remission Although the incidence of UC varies from 1 to 15 per 100,000 population in different locations, it increases year by year. Moreover, UC generally acts upon young people, and approximately 30% of patients with UC will undergo colectomy in the course of their life-times Thus, UC is a serious disease affecting the quality of life for a long period. It is now considered that IBD is not a simple inflammatory disease but a rather complicated disorder of intestinal components including epithelial cells, immune cells, neural cells, and extracellular matrix. Particular types of microbes, environmental factors including sanitary conditions and food, and genetic factors are also suggested to be involved Global approaches are therefore needed to reveal the pathogenesis of IBD, and to develop new therapeutic approaches for IBD as well. Chemokines have taken great attention since their discovery, because this family of chemotactic cytokines is intimately involved in the pathogenesis of many important human diseases. Developing new therapeutic approaches targeting several chemokines have been tried In this chapter, we will review the role of interferon--inducible protein (IP)-10 (IP-10/CXCL10) in the colon of normal condition and UC, introducing our recent findings about the effect of neutralization of IP-10 on animal models of UC. We also discuss about the possibility of clinical application of antagonist therapies targeting IP-10.