gebhart/patrepeval huggingface dataset:
Development of a New Fatigue and Creep Resistant PM Nickel-Base Superalloy for Disk Applications (2008)

Recent analysis of requirements and limitations in both economics and environmental issues of the development of modern turbine engines has led to redefine the specifications to be filled by superalloys for disk applications. Various criteria derived from these specifications helped to formulate a number of original alloy chemistries. These alloys were produced using powder metallurgy route at laboratory scale for microstructural and mechanical data collection. Two alloys were then selected for production by industrial processes and patented as SMO43 and SMO48. After thermomechanical treatments, the microstructural features and the mechanical properties of these two alloys were thoroughly evaluated. Tensile strength, LCF and FCG behaviours prove to be at least as good as N18's and creep strengths significantly higher. Finally, SMO43 appears to better fulfil the selection criteria.
The effect of water on discharge product growth and chemistry in Li–O2batteries (2016)

Understanding what controls Li-O2 battery discharge product chemistry and morphology is key to enabling its practical deployment as a low-cost, high-specific-energy energy conversion technology. Several studies have recently shown that the addition of substantial quantities (hundreds to thousands ppm) of water and weak acids to dimethoxyethane (DME)-based electrolytes can significantly increase Li-O2 battery discharge capacity, without substantially changing the discharge product chemistry, which remains Li2O2. The exact mechanisms behind these device-level improvements, however, are not yet understood. In this study, we show that the presence of water in a DME-based electrolyte decreases the rate of Li2O2 nucleation on the electrode surface during Li-O2 battery discharge, using potentiostatic electrochemical measurements, and direct, ex situ observations of Li2O2 particles. We also show that adding water to an acetonitrile (MeCN)-based electrolyte results in LiOH upon discharge, as opposed to only Li2O2. Using first principles calculations, we propose that this change in discharge product chemistry is attributable to increased proton availability, as shown by a lower pKa for water in MeCN than in DME. This study combines kinetic and morphological analyses with first principles calculations, and elucidates relationships among electrolyte composition, discharge product chemistry and growth mechanisms for the rational design of efficient metal-air batteries.
ChemInform Abstract: PC(sp3)P Transition Metal Pincer Complexes: Properties and Catalytic Applications (2013)

Abstract Review: 104 refs.
Application of an integrated wave-equation datuming scheme to overthrust data: A case history from the Chinese foothills (2009)

Abstract An integrated wave-equation datuming scheme improves the imaging quality of seismic data from overthrust areas. It can be regarded as integrated because upward-layer replacement is included. In this scheme, data are downward continued to a nonplanar datum (such as the base of the weathering layer), followed by upward continuation from the nonplanar datum to a final planar datum using a one-way extrapolator. When compared with a Kirchhoff integral, this method can deal better with the strong lateral velocity variation within the near surface. After a test on synthetic data, the scheme is applied successfully to real 2D overthrust data acquired in the Qi-Lian foothills, western China. Compared with results using static corrections, integrated wave-equation datuming results lead to better reconstruction of the diffractions and reflections, more reliable migration-velocity analyses, and stronger stack and final depth images.
Routes of Allergic Sensitization and Myeloid Cell IKKβ Differentially Regulate Antibody Responses and Allergic Airway Inflammation in Male and Female Mice (2014)

Gender influences the incidence and/or the severity of several diseases and evidence suggests a higher rate of allergy and asthma among women. Most experimental models of allergy use mice sensitized via the parenteral route despite the fact that the mucosal tissues of the gastrointestinal and respiratory tracts are major sites of allergic sensitization and/or allergic responses. We analyzed allergen-specific Ab responses in mice sensitized either by gavage or intraperitoneal injection of ovalbumin together with cholera toxin as adjuvant, as well as allergic inflammation and lung functions following subsequent nasal challenge with the allergen. Female mice sensitized intraperitoneally exhibited higher levels of serum IgE than their male counterparts. After nasal allergen challenge, these female mice expressed higher Th2 responses and associated inflammation in the lung than males. On the other hand, male and female mice sensitized orally developed the same levels of allergen-specific Ab responses and similar levels of lung inflammation after allergen challenge. Interestingly, the difference in allergen-specific Ab responses between male and female mice sensitized by the intraperitoneal route was abolished in IKKβΔMye mice, which lack IKKβ in myeloid cells. In summary, the oral or systemic route of allergic sensitization and IKKβ signaling in myeloid cells regulate how the gender influences allergen-specific responses and lung allergic inflammation.
SAR Focus Theory of Complicated Range Migration Signatures Due to Moving Targets (2018)

Recent studies have revealed that the residual range migration effects of synthetic aperture radar (SAR) imagery smears induced by moving targets can exhibit complicated shapes that are not limited to that of parabolas. This letter demonstrates that automatic focusing methods can remove such range migration effects by estimating and compensating for phase errors directly in the radar video phase history domain. This approach is validated using measured Ku-band SAR clutter data containing buildings and foliage.
Thermal Energy Test Apparatus (1991)

The Navy Clothing and Textile Research Facility (NCTRF) designed and fabricated a thermal energy test apparatus to permit evaluation of the heat protection provided by crash crew firefighter's proximity clothing materials against radiant and convective heat loads, similar to those found outside the flame zone of aircraft fuel fires. The apparatus employs electrically operated quartz lamp radiant heaters and a hot air convective heater assembly to produce the heat load conditions the materials are to be subjected to, and is equipped with heat flux sensors of different sensitivities to measure the incident heat flux on the sample material as well as the heat flux transmitted by the sample. Tests of the apparatus have shown that it can produce radiant heat flux levels equivalent to those estimated to be possible in close proximity to large aircraft fuel fires, and can produce convective heat fluxes equivalent to those measured in close proximity to aircraft fuel fires at upwind and sidewind locations. Work was performed in 1974.
ChemInform Abstract: First Total Synthesis of Bauerine C (V) (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Organotin(IV) complexes of N‐[(2Z)‐3‐hydroxy‐1‐methyl‐2‐butenylidene]glycine (2003)

Abstract Organotin(IV) derivatives of N‐[(2Z)‐3‐hydroxy‐1‐methyl‐2‐butenylidene]glycine have been synthesized and characterized by 1 H, 13 C, 119 Sn NMR, 119 Sn Mössbauer, and IR spectroscopy along with elemental analyses. The di‐ and triorganotin(IV) complexes were readily obtained from the reactions of organotin halides and sodium/potassium N‐[(2Z)‐3‐hydroxy‐1‐methyl‐2‐butenylidene]glycinate. The diorganotin compound reacted with Ph 3 SnCl in refluxing benzene to give the mixed organotin dinuclear complex of composition Ph 2 Sn(2‐OC(CH 3 )‐C(H)C(CH 3 )NCH 2 COO)·Ph 3 SnCl, which was characterized by single crystal X‐ray structure determination. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:149–154, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10116
Joint Path Alignment Framework for 3D Human Pose and Shape Estimation From Video (2023)

3D human pose and shape estimation (3D-HPSE) from video aims to generate sequence of 3D mesh that depict human body in the video. Current deep learning based 3D-HPSE networks that takes video input have focused on improving temporal consistency among sequence of 3D joints by supervising acceleration error between predicted and ground-truth human motion. However, these methods overlooked the geometric misalignments of persistent discrepancy between geometric paths drawn by sequence of predicted joints and that of ground-truth joints. To this end, we propose Joint Path Alignment (JPA) framework, a model-agnostic approach that mitigates geometric misalignments by introducing Temporal Procrustes Alignment Regularization (TPAR) loss that performs group-wise sequence learning of joint movement paths. Unlike previous methods that rely solely on per-frame supervision for accuracy, our framework adds sequence-level accuracy supervision with TPAR loss by performing Procrustes analysis on the geometric paths drawn by sequences of predicted joints. Our experiments show that JPA framework advances the network to exceed the previous state-of-the-art performances on benchmark datasets in both per-frame accuracy and video smoothness metric.
Efficient One-Pot Synthesis of the 2-Aminocarbonylpyrrolidin-4-ylthio-Containing Side Chain of the New Broad-Spectrum Carbapenem Antibiotic Ertapenem (2002)

An efficient synthesis of the 2-aminocarbonylpyrrolidin-4-ylthio containing side chain of ertapenem (MK-0826) is described. Starting material N-(O,O-diisopropyl phosphoryl)-trans-4-hydroxy-L-proline is converted in a one-pot process to (2S)-cis-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]amino]benzoic acid monohydrochloride in 70-75% overall yield via a series of six reactions. The development of each of these reactions and the isolation of the product is discussed in detail.
Two-Phase Materials Attrition Problems for Rankine Cycle Liquid Metal Power Plants (1966)

Research Papers Two-Phase Materials Attrition Problems for Rankine Cycle Liquid Metal Power Plants F. G. Hammitt F. G. Hammitt Laboratory for Fluid Flow and Heat Transport Phenomena, Department of Nuclear Engineering, The University of Michigan, Ann Arbor, Mich. Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information F. G. Hammitt Laboratory for Fluid Flow and Heat Transport Phenomena, Department of Nuclear Engineering, The University of Michigan, Ann Arbor, Mich. J. Eng. Power. Oct 1966, 88(4): 388-392 (5 pages) https://doi.org/10.1115/1.3678563 Published Online: October 1, 1966 Article history Received: October 20, 1965 Online: January 10, 2012
Nicotinamide protects chronic hypoxic myocardial cells through regulating mTOR pathway and inducing autophagy. (2019)

Nicotinamide induces the autophagy of chronic hypoxic myocardial cells by regulating the mTOR pathway, thereby protecting cells from apoptosis.
Prognostic Significance of POLE Proofreading Mutations in Endometrial Cancer (2014)

POLE proofreading mutations predict favorable EC prognosis, independently of other clinicopathological variables, with the greatest effect seen in high-grade tumors. This novel biomarker may help to reduce overtreatment in EC.
Wireless communication networks via aerial platforms: Dynamic fair power sharing admission control for UMTS real time traffic sources (2007)

Cellular communications using High Altitude Platform (HAPs) are studied for next generation broadband wireless network providing also Third Generation (3G) mobile services. The Connection Admission Control (CAC) issue in a HAP-UMTS communication system represents a key problem in order to increase the capacity in terms of admitted users preserving the agreement quality of service. The main problem of a full centralized admission control approach consists in an excessive calls blocking for the traffic sources located in the middle of the aerial platform coverage area, due to the high additive interference level generated by all active users. With the aim of resolving this issue, we propose a novel strategy for the admission procedure, based on dynamic power sharing (DFPS), in order to guarantee a high fairness level to all users of the implemented cellular system, in term of calls blocked in each cell. Furthermore, we compare this approach with a previous one based on full centralized power sharing (FCPS). Simulation results show that the proposed CAC scheme can achieve better performances than the previous one, managing the active connections in a "fair" manner also under high load conditions.
Computational measurement of tumor immune microenvironment in gastric adenocarcinomas (2018)

The use of four groups of tumor immune microenvironments (TME) based on PD-L1 and tumor-infiltrating T lymphocytes (TIL) is a reliable biomarker for anti-PD-1/PD-L1 inhibitor therapy. We classified the TME in 241 gastric cancers which were subdivided according to 40 EBV+, 76 microsatellite instability-high (MSI-H), and 125 EBV-/microsatellite-stable (MSS) subtypes by quantitative image analysis (QIA) and correlated the results with mRNA expression levels. The mean PD-L1 ratio and CD8 ratio in EBV+, MSI-H, and EBV-/MSS GCs were significantly different (P < 0.006). The PD-L1 ratio and CD8 ratio obtained by QIA correlated well with the RNA levels of PD-L1 (r = 0.63) and CD8 (r = 0.67), respectively. The TME were type I (PD-L1<sup>H</sup>/CD8<sup>H</sup>) in 45, type II (PD-L1<sup>L</sup>/CD8<sup>L</sup>) in 106, type III (PD-L1<sup>H</sup>/CD8<sup>L</sup>) in 8, and type IV (PD-L1<sup>L</sup>/CD8<sup>H</sup>) in 82 cases. The type I TME was significantly associated with high TIL (P = 3.0E-11) and EBV+ status (P = 8.55E-08). In conclusion, QIA results correlated well with the mRNA expression levels and classified TME of gastric cancers.
Cyclopropenium-Based Biodegradable Polymers (2019)

Cationic polymers offer a wide range of potential biomedical applications. Often, these materials suffer from a lack of degradability under biological conditions, preventing their translation in vivo. We present herein the synthesis and characterization of a series of novel biodegradable polymers bearing cationic cyclopropenium along a polyester backbone, either linear or cross-linked. The polymers are synthesized stepwise via the reaction between diol-functionalized tris(amino)-cyclopropenium (TAC) monomers and diacyl chlorides. Incorporation of the TAC moiety with a permanent, pH-independent charge, and hydrophobic groups with sufficient bulkiness causes the polyelectrolyte to form an aqueous dispersion of nanoparticles with a positive surface charge. Smaller hydrophobic TAC substituents inhibit nanoparticle formation because of a lack of hydrophobic bonds within the core of the nanoparticle. The polymers undergo hydrolytic degradation and swell significantly, displaying an important framework for the drug-delivery capabilities of a hydrolytically degradable cationic polyester. One polymer displayed potent antimicrobial activity against Staphylococcus epidermidis. These polymers may have use for the delivery of anionic bioactive agents.
Development and implementation of CARAS algorithm for automatic annotation, visualization, and GenBank submission of chloroplast genome sequences (2012)

We present CARAS, a web server that allows the automatic annotation of a chloroplast genome sequence, and the visualization and editing of the annotation results interactively and in real-time. CARAS accepts a complete chloroplast genome sequence as input. First, it accurately predicts protein-coding sequences and exon-intron structures by combining the results from two types of annotation approaches: ab initio prediction algorithms and similarity based methods. Second, tRNA genes and inverted repeats are identified using tRNAscan and vmatch. Using 220 chloroplast genome sequences as test, we show that CARAS outperforms a similar application DOGMA overall. Third, the annotation results are presented as a circular map that includes the name, location, orientation, and length of the various features. A Flex-based module is implemented, allowing the users to add, delete, and edit the features on-line. The results are stored on the server and can be retrieved from a given URL. Users also have options to download the annotation results in GFF3 format for further analyses in other third party software tools or in JPEG format for publication. Finally, CARAS can be used to create a Sequin file for GenBank submission of the annotated genome sequence. CARAS is freely available at http://caras.bicoup.com, and it will significantly facilitate research work involving chloroplast genomes.
[18F]Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography in Breast Cancer: When… and When Not? (2012)

Diagnostic imaging plays an important role in the care of patients with breast cancer and is used for breast cancer detection, diagnosis, staging, and therapeutic response evaluation. 1 Advances in imaging technology, especially relatively newer technologies such as magnetic resonance imaging (MRI) and positron emission tomography without or with integrated computed tomography (PET or PET/CT) provide powerful diagnostic tools, but also generate questions and controversy regarding where and when to use these new modalities. Early studies of new imaging approaches most often come from centers that are scientifically invested in the development of the technology. Typically, small and highly selected patient populations are evaluated, and these preliminary studies often indicate excellent diagnostic performance. Later on, when large multicenter trials are performed with more clinically representative patient populations, the new test invariably performs less well. Nevertheless, the excitement surrounding early results from a new imaging technology and the increasing public access to these early results fuel the desire by patients for access to new forms of diagnostic imaging. Physicians and patients share the wish for diagnostic certainty in excluding cancer spread at the time of diagnosis and may reason that a purely diagnostic procedure, even if untested, can do no harm. These factors, combined with the challenge and expense of carrying out larger scale diagnostic imaging trials, can lead to the early adoption of new imaging studies into clinical practice, often before their performance and optimal use have been fully determined. However, the use of a new imaging technology in populations of patients unlikely to benefit from its use can add anxiety, expense, unnecessary procedures, and delay in care. Equally important, inappropriate use in the wrong patient population can obfuscate benefit in other clinical settings where the imaging might be helpful. These dilemmas have been aptly demonstrated in the application of [ 18 F]fluorodeoxyglucose (FDG) PET and PET/CT to early breast cancer staging.
Dynamics of Sequence -Discrete Bacterial Populations Inferred Using Metagenomes (2014)

From a multi-year metagenomic time series of two dissimilar Wisconsin lakes we have assembled dozens of genomes using a novel approach that bins contigs into distinct genome based on sequence composition, e.g. kmer frequencies, and contig coverage patterns at various times points. Next, we investigated how these genomes, which represent sequence-discrete bacterial populations, evolved over time and used the time series to discover the population dynamics. For example, we explored changes in single nucleotide polymorphism (SNP) frequencies as well as patterns of gene gain and loss in multiple populations. Interestingly, SNP diversity was purged at nearly every genome position in some populations during the course of this study, suggesting these populations may have experienced genome-wide selective sweeps. This represents the first direct, time-resolved observations of periodic selection in natural populations, a key process predicted by the ecotype model of bacterial diversification.
[Hypertrophic cardiomyopathy with two episodes of recuperated sudden death. Report of the first implantable defibrillator cardioverter inserted in Chile]. (1994)

We report a 29 years old male with a non obstructive hypertrophic cardiomyopathy that survived two episodes of cardiac arrest and with a familiar history of the disease and sudden death. He had an implant of an automatic implantable cardioverter defibrillator by a left anterior thoracotomy with intraoperative electrophysiology. The postoperative outcome was uneventful. After one year of follow up, the patient is in good functional capacity and the implanted device has not performed defibrillations.
Human Cytomegalovirus and Human Herpesvirus 6 Genes That Transform and Transactivate (1999)

This review is an update on the transforming genes of human cytomegalovirus (HCMV) and human herpesvirus 6 (HHV-6). Both viruses have been implicated in the etiology of several human cancers. In particular, HCMV has been associated with cervical carcinoma and adenocarcinomas of the prostate and colon. In vitro transformation studies have established three HCMV morphologic transforming regions (mtr), i.e., mtrI, mtrII, and mtrIII. Of these, only mtrII (UL111A) is retained and expressed in both transformed and tumor-derived cells. The transforming and tumorigenic activities of the mtrII oncogene were localized to an open reading frame (ORF) encoding a 79-amino-acid (aa) protein. Furthermore, mtrII protein bound to the tumor suppressor protein p53 and inhibited its ability to transactivate a p53-responsive promoter. In additional studies, the HCMV immediate-early protein IE86 (IE2; UL122) was found to interact with cell cycle-regulatory proteins such as p53 and Rb. However, IE86 exhibited transforming activity in vitro only in cooperation with adenovirus E1A. HHV-6 is a T-cell-tropic virus associated with AIDS-related and other lymphoid malignancies. In vitro studies identified three transforming fragments, i.e., SalI-L, ZVB70, and ZVH14. Of these, only SalI-L (DR7) was retained in transformed and tumor-derived cells. The transforming and tumorigenic activities of SalI-L have been localized to a 357-aa ORF-1 protein. The ORF-1 protein was expressed in transformed cells and, like HCMV mtrII, bound to p53 and inhibited its ability to transactivate a p53-responsive promoter. HHV-6 has also been proposed to be a cofactor in AIDS because both HHV-6 and human immunodeficiency virus type 1 (HIV-1) have been demonstrated to coinfect human CD4(+) T cells, causing accelerated cytopathic effects. Interestingly, like the transforming proteins of DNA tumor viruses such as simian virus 40 and adenovirus, ORF-1 was also a transactivator and specifically up-regulated the HIV-1 long terminal repeat when cotransfected into CD4(+) T cells. Finally, based on the interactions of HCMV and HHV-6 transforming proteins with tumor suppressor proteins, a scheme is proposed for their role in oncogenesis.