gebhart/patrepeval huggingface dataset:
GERMANIUM. XXVII. GERMANIUM DICHLORIDE1 (1929)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGERMANIUM. XXVII. GERMANIUM DICHLORIDE1L. M. Dennis and H. L. HunterCite this: J. Am. Chem. Soc. 1929, 51, 4, 1151–1154Publication Date (Print):April 1, 1929Publication History Published online1 May 2002Published inissue 1 April 1929https://pubs.acs.org/doi/10.1021/ja01379a023https://doi.org/10.1021/ja01379a023research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MEDU-41. TARGETING GRANULOCYTE COLONY STIMULATION FACTOR RECEPTOR EXPRESSING MEDULLOBLASTOMA CELLS (2019)

Medulloblastoma can often be cured with resection, radiation, and chemotherapy, but recurrent disease has a dismal prognosis. Identifying mechanisms of disease recurrence is key to improving overall survival. Identifying sub-populations of medulloblastoma tumors with stem cell-like properties holds promise for reducing disease recurrence, but no unifying marker of medulloblastoma cancer stem cells has been found. The granulocyte stimulating factor receptor (GCSF-R or CD114) is well understood in the context of hematopoiesis. GCSF-R positive neuroblastoma and melanoma cells have cancer stem cell properties of chemoresistance and increased tumorigenicity, and are enriched after chemotherapy administration. GCSF-R is also expressed on a subpopulation of medulloblastoma cells. GCSF-R is particularly relevant as a cancer stem cell marker because its substrate, G-CSF, is used extensively in medulloblastoma treatment. GCSF-R exerts influence over the cell via the JAK-STAT pathway, presenting a potential therapeutic target. We show via flow cytometry that GCSF-R positive cells are identified in multiple medulloblastoma cell lines and PDX tumors, and that the GCSF-R+ subpopulation have a slower growth rate than GCSF-R- or mixed populations. In addition, GCSF selectively causes accelerated growth of GCSF-R+ cells in vitro. GCSF-R positive cells are more chemoresistant in vitro to vincristine, etoposide, and carboplatin. We also show that inhibitors of the JAK-STAT pathway have in vitro activity against medulloblastoma cell lines. We propose that GCSF-R represents a distinct subgroup of medulloblastoma cells which may evade traditional therapy. JAK-STAT inhibitors are already being used in other clinical contexts and may represent an adjunct therapy targeting overall tumor burden and specifically targeting GCSF-R+ cells via the JAK-STAT pathway.
Application of Bayesian network in information fusion analysis of four diagnostic methods of traditional Chinese medicine (2010)

Bayesian network is the effective tool for reasoning and modeling of complex and uncertain system based on traditional probability theory, which is widely used in uncertain decision-making, data analysis, intelligence reasoning and other fields. Syndrome differentiation and treatment, one of the basic characteristics of traditional Chinese medicine (TCM), is the essence of TCM. Fusion analysis on standardization and objectification of four diagnostic methods of TCM is the basic of syndrome differentiation analysis of TCM. The traditional methods are often with subjective differentiation and ambiguity, and the essence of syndrome differentiation of TCM can be seen as a classification problem. Bayesian network, as a better algorithm of data mining, is being increasingly applied to the study of syndrome differentiation of TCM. This article outlines the application of Bayesian network in information fusion analysis of four diagnostic methods of TCM and prospects for future research.
A hotspot attraction driven user mobility model and direction deciding algorithm (2010)

Mobility Model for mobile users is an important part of simulation of the wireless mobile network's resource management and optimization. The Manhattan Mobility Model proposed by ETSI is highly versatile. However, its random direction selecting strategy lacks of objectives, which means the scene of hotspot attracting user mobility could not be simulated accurately. In order to simulate the user mobility attracted by hotspots, a novel Hotspot Attraction Driven User Mobility Model (HADUMM) is proposed based on the Manhattan Mobility Model, and a Direction Deciding Algorithm (DDA) is designed. The HADUMM's realistic significance is evaluated.
Toward More Free-Floating Model Cell Membranes: Method Development and Application to Their Interaction with Nanoparticles (2016)

Identifying the mechanisms of nanoparticle (NP) interactions with cell membranes is key to understanding potential NP cytotoxicity and applications as nanocarriers for targeted drug delivery. To elucidate these mechanisms of interaction, supported phospholipid bilayers (SPBs) are commonly used as models of cell membranes. However, SPBs are soft thin films, and, as such, their properties can be significantly affected by the underlying substrate. Free-floating cell membranes would be best modeled by weakly adhered SPBs; thus, we propose a method for tailoring the interfacial interaction of an electrically charged SPB-substrate system based on modulations in the solution chemistry. Using the dissipation signal of the quartz crystal microbalance with dissipation monitoring (QCM-D), we show that the method can be used to tailor SPB-substrate interactions without the loss of its structural integrity. To demonstrate the application of the method, SPBs are exposed to cationic and anionic polystyrene latex NPs. These studies reveal that the bilayer response to the modulations in the interfacial interaction with its underlying substrate can be used as a sensitive tool to probe the integrity of SPBs upon exposure to NPs. As expected, anionic NPs tend to impart no significant damage to the anionic bilayers, whereas cationic NPs can be detrimental to bilayer integrity. This is the first report of a QCM-D based method to probe bilayer integrity following exposure to NPs. Importantly, the degree of SPB interaction with its underlying substrate is shown to be a critical factor in the kinetics of bilayer disruption by cationic NPs, whereby weakly adhered bilayers are prone to significantly faster breakup. Since free-floating cell membranes are better represented by a weakly adhered SPB, the results of this work critically influence paradigms in experimental studies involving SPBs as models for cell membranes.
Myocardial revascularization procedures on multisegment diseased left anterior descending artery: endarterectomy or multiple sequential anastomoses (jumping)? (1996)

Complete revascularization is the primary goal in coronary surgery because of its superior long term results. However, in some patients the extent of the coronary artery disease is such that the usual coronary bypass technique may not allow to perform a complete myocardial surgical revascularization and, consequently, a satisfactory myocardial perfusion: so complementary revascularization techniques may become mandatory, especially when the diseased vessel is LAD or its branches. As a consequence, alternative procedures should be undertaken: coronary endarterectomy (EA) and multiple sequential anastomoses on a single vessel (jump), which guidelines are actually somehow controversial. Between January, 1989, and May, 1992, 53 patients underwent a myocardial revascularization procedure on LAD system unsuitable for single distal bypass; of them 35 (66%) underwent coronary endarterectomy, while in 18 (34%) multiple sequential anastomoses (jumping) were performed on the same vessel. About preoperative variables, average NYHA class (2.7 jump vs 2.1 EA group, p < 0.05), the history of more than 1 myocardial infarction (22.2% jump vs 2.9% EA, p < 0.04) and the presence of preoperative nitrates e.v (33.3% vs 8.6%, p < 0.04) were statistically higher in the jump group, suggesting a more unstable clinical status, while other clinical echocardiographic and catheterization features were not statistically different. For what operative and postoperative features are concerned, the number of anastomoses performed was statistically higher in the jump group, as exasperated (3.8 vs 2.7, p < 0.002) while perfusion (138 vs 141 min) and crossclamp time (103 vs 106 min) were similar. Furthermore we found a statistically lower incidence of perioperative myocardial infarction (0% jump is 22.8% EA group, p < 0.04); the postperfusion inotropic drugs requirement (22.2% vs 37.1%), the need of an intraaortic counterpulsation (0% vs 2.9%) and the in-hospital mortality (0% vs 5.7%) were lower in the jumping group too, also if they didn't reach statistical significance. Our experience suggest, also with the limits imposed by a retrospective case review and by a low number of cases reported, that myocardial revascularization of a multisegment diseased LAD system may be safely performed with the jumping technique with a low incidence of postoperative complications: it should be the first choice technique when conventional revascularization procedures are not enough to achieve complete myocardial revascularization. We advocate the use of EA technique only in that cases characterized by a diffuse atherosclerotic core and a well delimited plane of dissection, associated to a very poor runoff, which really excludes any chance to multiple anastomoses.
Serum/Plasma depletion with chicken immunoglobulin Y antibodies for proteomic analysis from multiple Mammalian species. (2004)

Plasma from different species is the most accessible and valuable source for biomarker discovery in clinical and animal samples. However, due to the high abundance of some proteins such as albumin and immunoglobulins, low-abundant proteins are often undetectable in proteomic analysis of plasma. We have established a plasma depletion scheme using chicken antibodies against various abundant proteins. This immunoaffinity purification procedure is able to deplete albumin across multiple species. The high binding capacity and specificity of the chicken antibody enables the efficient capture of its ligand from microliter volumes of plasma sample. The resulting two-dimensional gel analyses of the depleted and captured samples show significant enhancement of the low-abundant proteins and specific capture of the abundant ligand. By utilizing this sample preparation scheme, it is now possible to analyze the plasma proteome from multiple species in a potentially rapid and large-scale capacity for biomarker discovery, drug target discovery, and toxicology studies.
Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoprotein. (1995)

The 72-kDa spleen tyrosine kinase (Syk) and Src-family kinase p53/56Lyn (Lyn) contribute to signaling via the B-cell antigen receptor complex. Here we show that Syk and Lyn from human B lymphocytes can interact directly. Syk and Lyn coimmunoprecipitated from mature and activated B-cell lines, and gel-purified Syk and Lyn reassociated in vitro, demonstrating their direct interaction. This Syk-Lyn interaction may be dependent on the stage of B-cell differentiation, since Syk-Lyn associations were not detected in pre-B and myeloma cell lines and Syk from an immature B-cell line did not reassociate with Lyn in vitro. Serine/threonine kinase activity was also associated with Syk. Crosslinking of cell surface IgM led to rapid activation of both tyrosine and serine/threonine protein kinase activities that resulted in phosphorylation in vitro of proteins coprecipitating with Syk--in particular, a serine/threonine phosphorylated protein 120 kDa in size (pp120). Several phosphoproteins, including one of 72 kDa and one of 120 kDa, coprecipitated with phospholipase C-gamma 1 (PLC gamma 1). Sequential immunoprecipitation identified the 72-kDa protein associated with PLC gamma 1 as Syk. The 120-kDa serine/threonine phosphorylated protein that coprecipitated with PLC gamma 1 resembled the Syk-associated pp120 by several criteria. Thus, pp120 may serve as a link between Syk and PLC gamma 1, coupling the B-cell antigen receptor to the phosphatidylinositol pathway.
L’oliguria in corso di laparoscopia: assenza di danno tubulare renale dopo valutazione con N-acetil- ß-D-glucosaminidasi (1997)

L’oliguria in corso di laparoscopia: assenza di danno tubulare renale dopo valutazione con N-acetil- ß-D-glucosaminidasi
Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors (2004)

Article Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors was published on June 7, 2004 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 42, issue 6).
A measure for quantifying the impact of housing quality on respiratory health: a cross-sectional study (2012)

This study showed that increased evidence of housing conditions supporting dampness and mould was associated with increased odds of respiratory symptoms. A valid housing assessment tool can provide a rational basis for investment in improved housing quality to improve respiratory health.
Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1 (2010)

The bacterial burden on human health is quickly outweighing available therapeutics. Our long-term goal is the development of antimicrobials with the potential for broad-spectrum activity. We previously reported phthalazine-based inhibitors of dihydrofolate reductase (DHFR) with potent activity against Bacillus anthracis, a major component of Project BioShield. The most active molecule, named RAB1, performs well in vitro and, in a cocrystal structure, was found deep within the active site of B. anthracis DHFR. We have now examined the activity of RAB1 against a panel of bacteria relevant to human health and found broad-spectrum applicability, particularly with regard to gram-positive organisms. RAB1 was most effective against Staphylococcus aureus, including methicillin- and vancomycin-resistant (MRSA/VRSA) strains. We have determined the cocrystal structure of the wild-type and trimethoprim-resistant (Phe 98 Tyr) DHFR enzyme from S. aureus with RAB1, and we found that rotational freedom of the acryloyl linker region allows the phthalazine moiety to occupy two conformations. This freedom in placement also allows either enantiomer of RAB1 to bind to S. aureus, in contrast to the specificity of B. anthracis for the S-enantiomer. Additionally, one of the conformations of RAB1 defines a unique surface cavity that increases the strength of interaction with S. aureus. These observations provide insights into the binding capacity of S. aureus DHFR and highlight atypical features critical for future exploitation in drug development.
Compiling dynamic mappings with array copies (1997)

Array remapping are useful to many applications on distributed memory parallel machines. They are available in High Performance Fortran, a Fortran-based data-parallel language. This paper describes techniques to handle dynamic mappings through simple array copies: array remapping are translated into copies between statically mapped distinct versions of the array. It discusses the language restrictions required to do so. The remapping graph which captures all remapping and liveness information is presented, as well as additional data-flow optimizations that can be performed on this graph, so as to avoid useless remapping at run time. Such useless remapping appear for arrays that are not used after a remapping. Live array copies are also kept to avoid other flow-dependent useless remappings. Finally the code generation and runtime required by our scheme are discussed. These techniques are implemented in our prototype HPF compiler.
Ognall (1896)

Journal Article Ognall Get access J. G. C. J. G. C. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s8-IX, Issue 212, 13 January 1896, Page 48, https://doi.org/10.1093/nq/s8-IX.212.48f Published: 13 January 1896
Bone scintigraphy in two siblings with pulmonary alveolar microlithiasis (1985)

Pulmonary alveolar microlithiasis (PAM), is a rare disorder of unknown aetiology, characterised by the formation of tiny calcium phosphate calculi in the pulmonary alveoli (Prakash et al, 1983). About 50% of the cases are familial, mainly in siblings (Sosman et al, 1957) and the disease is usually diagnosed incidentally by the characteristic chest X-ray findings. Patients generally remain asymptomatic for many years, but most eventually develop restrictive lung disease and a few die as a result of severe hypoxaemia and cor pulmonale (Prakash et al, 1983; Sosman et al, 1957). The typical radionuclide appearance of PAM, using 99Tcm-MDP scintigraphy of chest, has been described only twice (Brown et al, 1978; Shigeno et al, 1982). This is the first description of the typical scintigraphic pattern of PAM in two siblings, one of them asymptomatic. The use of radiography in conjunction with scintigraphy for the early diagnosis of PAM in asymptomatic relatives of patients with PAM, is suggested.
Diode-pumped low noise CW 355-nm intra-cavity tripled laser up to 20 mW (2006)

Low noise lasers in the UV spectrum (355 nm) are important for many applications like spectroscopy, confocal microscopy, flow cytometry, cell sorting, CD mastering, semiconductor inspection and reprographics. The UV CW laser sources currently commercially available, are restricted to excimers lasers, gas ions lasers which suffer from low power efficiency (0.01% or less), high electrical consumption and bulky dimensions. These products, which are expensive, are still waiting for practical replacements. To our best knowledge, we report in this paper the first efficient low noise diode-pumped neodymium doped solid-state laser operating at 355 nm by intra-cavity third harmonic generation (THG). The fundamental infrared laser light is generated by a diode-pumped Nd:YVO<sub>4</sub> crystal optically contacted with others components of the laser cavity. Intra-cavity SHG and THG are achieved with a KTP and LBO respectively. Several configurations have led to low noise 355 nm single-frequency operation at a power exceeding 10 mW. We believe that this power can still be improved.
High-Throughput Rapid Single-Flux-Quantum Circuit Implementations for Exponential and Logarithm Computation Using the Radix-2 Signed-Digit Representation (2016)

We present circuit implementations for computing exponentials and logarithms suitable for rapid single-flux-quantum (RSFQ) logic. We propose hardware algorithms based on the sequential table-lookup (STL) method using the radix-2 signed-digit representation that achieve high-throughput, digit-serial calculations. The circuits are implemented by processing elements formed in systolic-array-like, regularly-aligned pipeline structures. The processing elements are composed of adders, shifters, and readouts of precomputed constants. The iterative calculations are fully overlapped, and throughputs approach the maximum throughput of serial processing. The circuit size for calculating significand parts is estimated to be approximately 5-10 times larger than that of a bit-serial floating-point adder or multiplier.
Application Design Space Exploration (SPACE4AI-D) (2021)

The repository includes the source code and the datasets of SPACE4AI-D which is a design time tool of the AI-SPRINT. The results are included in the AI-SPRINT project deliverable "D2.1 - First release and evaluation of the AI-SPRINT design tools".
SU‐E‐J‐115: Correlation of Displacement Vector Fields Calculated by Deformable Image Registration Algorithms with Motion Parameters of CT Images with Well‐Defined Targets and Controlled‐Motion (2015)

Purpose: To investigate correlation of displacement vector fields (DVF) calculated by deformable image registration algorithms with motion parameters in helical axial and cone‐beam CT images with motion artifacts. Methods: A mobile thorax phantom with well‐known targets with different sizes that were made from water‐equivalent material and inserted in foam to simulate lung lesions. The thorax phantom was imaged with helical, axial and cone‐beam CT. The phantom was moved with a cyclic motion with different motion amplitudes and frequencies along the superior‐inferior direction. Different deformable image registration algorithms including demons, fast demons, Horn‐Shunck and iterative‐optical‐flow from the DIRART software were used to deform CT images for the phantom with different motion patterns. The CT images of the mobile phantom were deformed to CT images of the stationary phantom. Results: The values of displacement vectors calculated by deformable image registration algorithm correlated strongly with motion amplitude where large displacement vectors were calculated for CT images with large motion amplitudes. For example, the maximal displacement vectors were nearly equal to the motion amplitudes (5mm, 10mm or 20mm) at interfaces between the mobile targets lung tissue, while the minimal displacement vectors were nearly equal to negative the motion amplitudes. The maximal and minimal displacement vectors matched with edges of the blurred targets along the Z‐axis (motion‐direction), while DVF's were small in the other directions. This indicates that the blurred edges by phantom motion were shifted largely to match with the actual target edge. These shifts were nearly equal to the motion amplitude. Conclusions: The DVF from deformable‐image registration algorithms correlated well with motion amplitude of well‐defined mobile targets. This can be used to extract motion parameters such as amplitude. However, as motion amplitudes increased, image artifacts increased significantly and that limited image quality and poor correlation between the motion amplitude and DVF was obtained.
Gene Expression Profiles during the Initial Phase of Salt Stress in Rice (2001)

Shinji Kawasaki, Chris Borchert, Michael Deyholos, Hong Wang, Susan Brazille, Kiyoshi Kawai, David Galbraith, Hans J. Bohnert, Gene Expression Profiles during the Initial Phase of Salt Stress in Rice, The Plant Cell, Vol. 13, No. 4 (Apr., 2001), pp. 889-905