gebhart/patrepeval huggingface dataset:
Abstract 254: Systems-Based Statewide Program for Cardiac Resuscitation Leads to Increased Survival Over Time: A Report of the 5 Initial States in the Heart Rescue Project (2014)

Introduction: The Heart Rescue Project aims to improve survival from out-of-hospital cardiac arrest by supporting implementation of community-based best practices for the management of cardiac arrest patients. The project is supported by the Medtronic Foundation and is currently in its 4th year. Five university-based consortia sought to improve survival for their respective states: Universities of Minnesota, Pennsylvania, Washington, Arizona and Duke University. Methods: The statewide initiatives included multifaceted programs that spanned the chain of survival. The activities included improving bystander CPR rates by increasing public awareness and education, optimizing prompt delivery and quality of CPR, facilitating interdisciplinary medical specialty programs and improving in-hospital post-arrest care, primary percutaneous coronary intervention, and optimal intensive care. Importantly, the HRP mandated prospective collection of data through the Cardiac Arrest Registry to Enhance Survival (CARES) to measure outcomes of cardiac arrest. We report outcomes from 2011 to 2013. A t-test for survival rates was performed between 2011 and 2013. Significance was set for p Results: In 2013 the efforts covered an overall population of 30 million people. The average survival rate of the 5 states for a witnessed arrest presenting with all rhythms increased from 15.0±5.2% in 2011 to 15.4±5.6% in 2012 and to 16.9±5.7% (p=0.005). In patients with shockable rhythms, survival to hospital discharge increased from 27.4 ±13.0% to 28.7±13.6% to 31.8 ±15.7% (p = 0.04) from 2011 to 2013 respectively. During this same time period, bystander CPR rates increased from 36.2±9 to 39±10 to 43.4±9.6 (p Conclusion: The Heart Rescue Project has led to a significant collective improvement in survival for patients with witnessed OHCA over 3 years in 5 states. This program provides a useful model for statewide quality improvement and is actively expanding to new partners and neighboring states.
Immersive Visualizations in a VR Cave Environment for the Training and Enhancement of Social Skills for Children with Autism (2014)

Autism is a complex developmental disorder characterized by severe impairment in social, communicative, cognitive and behavioral functioning. Several studies investigated the use of technology and Virtual Reality for social skills training for people with autism with promising and encouraging results (D. Strickland, 1997; Parsons S. & Cobb S., 2011). In addition, it has been demonstrated that Virtual Reality technologies can be used effectively by some people with autism, and that it had helped or could help them in the real world; (S. Parsons, A. Leonard, P. Mitchell, 2006; S. Parsons, P. Mitchell, 2002). The goal of this research is to design and develop an immersive visualization application in a VR CAVE environment for educating children with autism. The main goal of the project is to help children with autism learn and enhance their social skills and behaviours. Specifically, we will investigate whether a VR CAVE environment can be used in an effective way by children with mild autism, and whether children can benefit from that and apply the knowledge in their real life.
Malignant angioendotheliomatosis with retinal detachments in a dog (1995)

A Golden Retriever with bilateral conjunctival hyperemia, chemosis, and blepharospasm was determined to have malignant angioendotheliomatosis, which is an uncommon neoplastic disorder of dogs and human beings. It was believed to be of endothelial origin, but evidence in human beings indicates a lymphoid origin. The histogenesis of the disease in the dog was confirmed to be of lymphoid origin by use of a canine lymphoma-specific immunoperoxidase assay. The prognosis for malignant angioendotheliomatosis in dogs is poor, but with early diagnosis, the condition is potentially manageable.
Self-assembled monolayers of alkanethiols on Au(111): surface structures, defects and dynamics (2005)

The surface structures, defects and dynamics of self-assembled monolayers (SAMs) on Au(111) are reviewed. In the case of the well-known c(4 x 2) and radical 3 x radical 3 R30 degrees surface structures, the present discussion is centered on the determination of the adsorption sites. A more complex scenario emerges for the striped phases, where a variety of surface structures that depends on surface coverage are described. Recently reported surface structures at non-saturation coverage show the richness of the self-assembly process. The study of surface dynamics sheds light on the relative stability of some of these surface structures. Typical defects at the alkanethiol monolayer are shown and discussed in relation to SAMs applications.
Adaptive time slots control in wireless sensor networks for delay-aware applications (2014)

Wireless Sensor Networks (WSNs) have been proposed for various monitoring applications including environmental, industrial, military and health care. The use of WSNs with cluster-tree topologies for such applications solves the limited coverage issue of the wireless sensor devices and allows them to be deployed in wider area. WSNs with cluster-tree topologies suffer from various problems including accurate synchronization of beacons used in the beacon enabled mode in the IEEE 802.15.4 standard and providing Quality of Service (QoS) to delay-aware applications. In this paper, we present a Time Slot Control (TSC) scheme that can adaptively manage the allocation of time slots in the beacon enabled mode of operation to provide QoS grantees to delay critical traffic. Our proposed scheme can improve the end-to-end delay and throughput of selected traffic types by managing the time slots between sensor devices in an optimum way.
Efficacy of hemodialysis and the effects of certain displacing agents on plasma protein binding of sulfamethoxazole and sulfaphenazole in patients with chronic renal failure. (1980)

The binding of sulfamethoxazole and sulfaphenazole to the plasma protein of 7 patients with chronic renal failure, undergoing chronic hemodialysis, was studied by the equilibrium dialysis method and the results were compared with those for 12 normal subjects. The binding percentages of the two sulfonamides were found to be impared in the patients'plasma as compared with normal plasma. The binding percentages increased in the patients'plasma after hemodialysis except in the cases of 2 patients for sulfamethoxazole (SMX) and 1 patient for sulfaphenanzole (SPH). The effect of hemodialysis on drug protein binding was examined by calculating the percentage displacement of bound sulfonamides by oxyphenbutazone and sulfinpyrazone. Percentage displacements were higher in the patients' plasma than in normal plasma. The percentage displacement decreased in the patients'plasma after hemodialysis, except in the cases of 1 patient for SMX and 1 patient for SPH. Such a decrease in the percentage displacement after hemodialysis suggests that the drug binding activity of plasma albumin can be improved through hemodialysis for patients with chronic renal failure.
Keyword Generation for Search Engine Advertising (2006)

Keyword generation for search engine advertising is an important problem for sponsored search or paid-placement advertising. A recent strategy in this area is bidding on nonobvious yet relevant words, which are economically more viable. Targeting many such nonobvious words lowers the advertising cost, while delivering the same click volume as expensive words. Generating the right nonobvious yet relevant keywords is a challenging task. The challenge lies in not only finding relevant words, but also in finding many such words. In this paper, we present TermsNet, a novel approach to this problem. This approach leverages search engines to determine relevance between terms and captures their semantic relationships as a directed graph. By observing the neighbors of a term in such a graph, we generate the common as well as the nonobvious keywords related to a term
Synthesis and characterization of imide end‐capped oligoesters of terephthalic acid and 2‐methyl‐2‐propyl‐1,3‐propanediol (1990)

Abstract Hydroxytelequelic oligoesters of molecular weight ( M n ) between 500 and 3000 were prepared from dimethylterephthalate (DMT) and 2‐methyl‐2‐propyl‐1,3‐propanediol (MPPD) by ester interchange polycondensation. They were modified by reaction of their end hydroxyl groups with N ‐(4‐chlorocarbonylphenyl) maleimide and N ‐(4‐chlorocarbonylphenyl) nadimide. Spectroscopic (NMR), chromatographic (GPC), and calorimetric (DSC) analyses demonstrated that MPPD oligoterephthalates are less reactive than previously used glycols (diethylene glycol, DEG) and only nadimide‐modified oligomers could be readily synthesized. Attempts to introduce maleimide groups at the chain ends led to crosslinked materials. Furthermore, some relationships between molecular weight and properties ( T g , thermal stability, etc.) could be outlined. The oligomers, unmodified and modified, proved to be essentially amorphous.
Hippocampal morphology mediates biased memories of chronic pain (2017)

Experiences and memories are often mismatched. While multiple studies have investigated psychological underpinnings of recall error with respect to emotional events, the neurobiological mechanisms underlying the divergence between experiences and memories remain relatively unexplored in the domain of chronic pain. Here we examined the discrepancy between experienced chronic low back pain (CBP) intensity (twice daily ratings) and remembered pain intensity (n = 48 subjects) relative to psychometric properties, hippocampus morphology, memory capabilities, and personality traits related to reward. 77% of CBP patients exaggerated remembered pain, which depended on their strongest experienced pain and their most recent mood rating. This bias persisted over nearly 1 year and was related to reward memory bias and loss aversion. Shape displacement of a specific region in the left posterior hippocampus mediated personality effects on pain memory bias, predicted pain memory bias in a validation CBP group (n = 21), and accounted for 55% of the variance of pain memory bias. In two independent groups (n = 20/group), morphology of this region was stable over time and unperturbed by the development of chronic pain. These results imply that a localized hippocampal circuit, and personality traits associated with reward processing, largely determine exaggeration of daily pain experiences in chronic pain patients.
Cellular analysis of the mode of action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy) benzoate (DIME) on tumor cells (1997)

The hormonally inactive methyl-3,5-diiodo-4-(4'-methoxyphenoxy) benzoate (DIME) at 1-4 mu M concentration induces morphologic changes in E-ras 20 and MDA-MB-231 and other human cancer cells such as multinucleation and enlargement and arrests the cell cycle in the M phase without affecting interphase. Time-lapse videomicroscopy allowed us to follow individual cells. Cells exposed to DIME divided in an abnormal manner, leading to 20% cell fusion and multinucleation. Chromosome painting demonstrated a large accumulation of chromosomes after 5 days of treatment with DIME, consistent with the failure of cells to divide normally. Chromosome breakage was not observed. On the other hand, highly abnormal tubulin-containing structures ensue upon exposure to DIME (1 mu M for 18 h) treatment, indicating an early biochemical action of DIME on the spindle assembly system.
Simple and safe SQL queries with c++ templates (2007)

Most software applications use a relational database for data man-agement and storage. Interaction with such a database is often done by letting the program construct strings with valid SQL statements, which are then sent for execution to the database engine. The fact that these statements are only checked for correctness at runtime is a source for many potential problems such as type and syntax errors and vulnerability to injection attacks. The ARARAT system presented here offers a method for dealing with these predicaments, by coercing the host C++ compiler to do the necessary checks of the generated strings. A library of templates (and preprocessor directives) effectively extends C++ with a little language representing an augmented relational algebra formalism. Type checking of this language extension, as done by the template library, assures, at compile-time, the correctness of the generated SQL strings. All SQL statements constructed by the system are immune to injection attacks. Standard techniques (e.g., “expression templates”) for compile time representation of symbolic structures, are enhanced by our system to support a type system and a symbol table lookup of the symbolic structure. Our work may also open the way for embed-ding other domain specific languages in C++. 1.
Circulating tumor cells - not serum tumor markers - predict survival in metastatic breast cancer (2005)

9516 Background: The presence of ≥5 circulating tumor cells (CTCs) in 7.5mL of blood in women with metastatic breast cancer (MBC) is associated with poor outcome (NEJM 2004). Here we provide previously unreported data from this multi-center trial on the assessment of the serum tumor marker MUC-1 (CA27.29 and/or CA15–3). Methods: In 65 of 177 MBC patients CTCs were assessed at 1st follow-up and MUC-1 at baseline, 1st follow-up (n=65), and the first disease reassessment (V1) after initiation of therapy (n=54). Assessment of MUC-1 was not mandated by the protocol and was only available from investigators that performed the assay as part of their routine assessment. CTCs were immunomagnetically separated and fluorescently labeled using the CellSearch Kit. Only nucleated (DAPI+) cells with the phenotype EpCAM+, Cytokeratin 8, 18 and/or 19+, and CD45- were counted using the CellSpotter Analyzer. Patients were classified as positive when ≥5 CTCs/7.5mL were detected. Patients were classified as positive when MUC-1 increased by 25% over the two time points. Results: Twenty-four of 65 (37%) patients had ≥ 5CTCs, 19 of 65 (29%) and 18 of 54 (33%) had >25% increase in MUC-1 at 1st follow-up and V1 respectively. CTCs and change in MUC-1 did not significantly correlate at any time point. In a univariate Cox hazards regression analysis, significant parameters for Progression Free Survival (PFS) were type of therapy (p=0.0197), change in MUC-1 (p≤0.0008), and CTCs (p=0.0008). For Overall Survival (OS) significant parameters were ER/PR (p=0.0172), ECOG (p=0.0128), type of therapy (p=0.0314) and CTCs (p=0.0064). MUC-1 was not significant for OS at 1st follow-up or 1st disease reassessment (p≥0.2255). In multivariate analyses, CTCs remained the strongest and most significant independent predictor of poor outcome. Conclusions: A significant correlation between PFS and change in serum MUC-1 tumor marker and CTCs was found in MBC. MUC-1 however did not correlate with overall survival. The presence of CTCs after initiation of therapy strongly correlates with survival and may be a more appropriate surrogate measure of disease progression. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Immunicon Immunicon
Photon-induced conduction modulation in SiO2 thin films embedded with Ge nanocrystals (2007)

The authors report the photon-induced conduction modulation in SiO2 thin films embedded with germanium nanocrystals (nc-Ge). The conduction of the oxide could be switched to a higher- or lower-conductance state by a ultraviolet (UV) illumination. The conduction modulation is caused by charging and discharging in the nc-Ge due to the UV illumination. If the charging process is dominant, the oxide conductance is reduced; however, if the discharging process is dominant, the oxide conductance is increased. As the conduction can be modulated by UV illumination, it could have potential applications in silicon-based optical memory devices.
Non-distorted texture mapping for sheared triangulated meshes (1998)

This article introduces new techniques for non-distorted texture mapping on complex triangulated meshes. Texture coordinates are assigned to the vertices of the triangulation by using an iterative optimization algorithm, honoring a set of constraints minimizing the distortions. As compared to other global optimization techniques, our method allows the user to specify the surface zones where distortions should be minimized in order of preference. The modular approach described in this paper results in a highly flexible method, facilitating a customized mapping construction. For instance, it is easy to align the texture on the surface with a set of user defined isoparametric curves. Moreover, the mapping can be made continuous through cuts, allowing to parametrize in one go complex cut surfaces. It is easy to specify other constraints to be honored by the so-constructed mappings, as soon as they can be expressed by linear (or linearizable) relations. This method has been integrated successfully within a widely used C.A.D. software dedicated to geosciences. In this context, applications of the method comprise numerical computations of physical properties stored in fine grids within texture space, unfolding geological layers and generating grids that are suitable for finite element analysis. The impact of the method could be also important for 3D paint systems.
A compact ridge filter for spread out Bragg peak production in pulsed proton clinical beams (2001)

A number of designs have been proposed for ridge filters and range modulators used in proton therapy to modify the beam in order to spread out the Bragg peak. Despite the variety of solutions, no simple design capable of providing large fields and easy variation of the spread out Bragg peak (SOBP) length in a pulsed beam has been developed. We propose a compact ridge filter that can be used in a proton beam of any time structure. It allows the production of depth dose distributions that meet the requirements of therapy dose fields.
hsa-miR-4516 Mediated Downregulation of STAT3/CDK6/UBE2N Plays a Role in PUVA Induced Apoptosis in Keratinocytes (2014)

Psoriasis is a chronic inflammatory skin disorder mediated by cross-talk occurring between epidermal keratinocytes, dermal vascular cells and immunocytes. Literature reveals that Signal transducer and activator of transcription 3 (STAT3), a protein involved in transmitting extracellular signals to the nucleus, is a possible important link between keratinocytes and immunocytes and is crucial to the development of psoriasis. Although photochemotherapy using UV in combination with 8 methoxypsoralen is one of the most effective therapy for moderate to severe plaque psoriasis, its mechanism of action is largely unknown. Herein, we studied the change in miRNA profiles of cultured human keratinocytes (HaCaT cells) before and after in vitro PUVA treatment by 8 methoxypsoralen and found significant up regulation of hsa-miR-4516. We for the first time demonstrate that ectopic expression of hsa-miR-4516 directly targets STAT3 protein by binding to its 3'UTR in HaCaT cells as confirmed by Luciferase reporter assays and Western blot analysis. We further show that overexpression of hsa-miR-4516 downregulates STAT3, p-STAT3, CDK6, and UBE2N proteins that are consistently upregulated in psoriasis and induces apoptosis in HaCaT cells. We also observed that anti-miR-4516 treatment was able to partially inhibit PUVA-induced apoptosis, suggesting that miR-4516 is involved in PUVA-induced apoptosis. Taken together, these results not only indicate the mechanistic involvement of hsa-miR-4516 in PUVA mediated effects by down-regulating STAT3 in HaCaT keratinocytes, but also highlight the potential of hsa-miR-4516 in development of novel therapeutic strategies. J. Cell. Physiol. 229: 1630-1638, 2014. © 2014 Wiley Periodicals, Inc.
ChemInform Abstract: Preparation, Stereochemistry, and Reactions of the Bis(spirodienone) Derivatives of p‐tert‐Butylcalix(4)arene. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
SYNTHESIS OF NOVEL 8-SUBSTITUTED CARBOCYCLIC ANALOGS OF 2′,3′-DIDEOXYADENOSINE WITH ACTIVITY AGAINST HEPATITIS B VIRUS (2002)

Synthesis and antiviral activity of several new 8-substituted carbocyclic analogs of D-2',3'-dideoxyadenosine are described. The new 8-substituted analogs were synthesized via lithiation of carbocyclic 2',3'-dideoxyadenosine followed by quenching with electrophiles. This methodology allows for a divergent synthesis of a variety of 8-substituted analogs from carbocyclic 2',3'-dideoxyadenosine in high yields. 8-Methyl and 8-halogenated carbocyclic 2',3'-dideoxyadenosine analogs showed 6-25 fold more activity against hepatitis B virus than the unsubstituted carbocyclic D-2',3'-dideoxyadenosine.
Acid-catalyzed disproportionation of N,N-bis(4-tert-butylphenyl)hydroxylamine. Synthesis and structure of 10-[5-tert-butyl-2-(4-tert-butylphenylamino)phenyl]-3,7-di-tert-butylphenoxazine (2014)

New method of synthesis was developed for N,N-bis(4-tert-butylphenyl)hydroxylamine by reduction of the corresponding aminoxyl with hydrazine hydrate. At the treatment with strong acids this hydroxylamine derivative is converted in bis(4-tert-butylphenyl)amine and 10-[5-tert-butyl-2-(4-tert-butylphenylamino) phenyl]-3,7-di-tert-butylphenoxazine. The structure of the latter was established by X-ray diffraction analysis. The mechanism was suggested of the acid-catalyzed disproportionation of N,N-bis(4-tert-butylphenyl) hydroxylamine.
Implanting the Glucose Enzyme Electrode: Problems, Progress, and Alternative Solutions (1982)

An implantable glucose sensor is needed before a reliable artificial pancreas can be realized. The principles and current status of one such device, the glucose enzyme electrode, is presented and discussed. While monitoring glucose this enzyme sensor consumes enough oxygen to become oxygen-limited. This problem has been solved by developing hydrophobic membranes that are more permeable to oxygen than to glucose. Two types of membranes with this property made from (1) cross-linked albumin and (2) sebacyl chloride (nylon) are described. Placing these membranes over the glucose enzyme electrode solves the problem of oxygen limitation. Furthermore, the addition of this type of membrane increases the linear response range of the electrode to glucose to include the entire clinical range of interest (0-400 mg/dl). Other problems in developing an implantable glucose sensor are discussed. Competing strategies to achieve an implantable artificial pancreas without using electronic or mechanical components are presented and evaluated.