gebhart/patrepeval huggingface dataset:
RECIST measurement through the exhaled breath in lung cancer: Myth or reality? (2014)

e19023 Background: Exhale breath analysis can assist in early detection of lung cancer (LC). The cancerous cells induce biochemical changes that cause a release of various compounds to blood, some of which are then exhaled at breath as Volatile Organic Compounds (VOCs). We examine whether exhaled breath analysis can be used for monitoring response to systemic therapy in lung cancer patients, as a potential non-invasive tool. Methods: The first breath sample was collected prior to the beginning of first systemic therapy. Repeated samples were collected during treatment period. Computerized tomography (CT) scans were done periodically. Patients' response to treatment was assessed by CT scans, and categorized according to RECIST [RECIST criteria- the Response Evaluation Criteria in Solid Tumors] criteria as: Complete Response (CR), Partial Response (PR), Progressive Disease (PD), or Stable Disease (SD). VOCs profiles were determined by GC-MS [gas-chromatography/mass-spectrometry] and by nanomaterial-based array of sensor. Results: 38 patients with stage III/IV lung cancer were recruited to our study. 33 of the patients had non-small cell lung cancer (NSCLC) and 6 patients had small cell lung cancer (SCLC). 143 breath samples were collected; the number of samples per patients ranges from 2 to 12 samples, with a median of 3 samples. 48 samples were categorized as PR, 36 as SD, and 18 as PD.In order to identify compounds / patterns which distinguish the response categories, comparisons were conducted at 4 levels: baseline samples vs. PR+SD; baseline samples vs. PD; PR vs. SD; PR+SD vs. PD. VOC signature was able to discriminate between disease control and PD by a set of four isolated VOCs in a significant manner. Conclusions: Breath sampling can pose an important tool in clinical practice for the detection of lung cancer, and may serve as a non-invasive biomarker to monitor response to anti-cancer treatment, even before it is indicated by imaging tests. Clinical trial information: NCT01386203.
TRANSPLANTE RENAL CRUZADO EM PORTUGAL – UM EXEMPLO DE SUCESSO (2019)

Até 30% dos pares de dador vivo não são transplantados por incompatibilidade do grupo ABO e/ou do sistema Human Leukocyte Antigen (HLA). Os programas de doação renal cruzada surgiram como uma estratégia para tentar ultrapassar estas barreiras. Em Portugal o Programa Nacional de Doação Renal Cruzada (PNDRC) foi legislado em 2010 e o primeiro transplante renal cruzado ocorreu em 2013. Até ao momento foram efetuados 22 transplantes deste tipo. Objetivo: O presente trabalho visa avaliar as caraterísticas e perfil evolutivo dos doentes submetidos a transplante renal cruzado em Portugal. Métodos: Os autores apresentam um estudo observacional retrospetcivo com análise dos respetivos doentes. Resultados: Da amostra total, a maioria dos recetores era do sexo masculino (55%), com idade mediana 53 anos. A poliquistose renal foi a etiologia da doença renal mais comum (18%) e a maioria dos doentes encontrava-se previamente em programa crónico de hemodiálise (68%). Três doentes apresentaram Calculated Panel Reactive Antibody (PRAc) superior a 98% e 10 PRAc superior a 80%. Foi realizada indução de imunossupressão com Anti-Thymocyte Globulin (ATG) em 50% dos doentes e imunomodulação com Rituximab e/ou plasmaferese em 15%. Todos os recetores evoluíram com função imediata do enxerto. Não se registaram complicaçães major, com eventos minor em 15%. Num tempo mediano de follow-up de 2 7 [ 2-46] meses, não se verificou nenhum caso de rejeição celular aguda e a penas um de rejeição humoral. As sobrevidas do dador e recetor foram ambas 100%. Conclusão: A apresentação destes resultados preliminares excelentes visa estimular o aumento do número de pares a incluir no PNDRC e um maior número de transplantes efetuados no programa. Tal como uma parte significativa desta amostra, o transplante renal cruzado pode constituir uma possibilidade para doentes com incompatibilidade do sistema HLA e/ou do grupo ABO. A doação renal cruzada em muito engrandece a doação em vida, oferecendo a pares incompatíveis e selecionados, uma oportunidade de transplantação renal com sucesso.
Reticulocalbin-1 Facilitates Microglial Phagocytosis (2015)

Phagocytosis is critical to the clearance of apoptotic cells, cellular debris and deleterious metabolic products for tissue homeostasis. Phagocytosis ligands directly recognizing deleterious cargos are the key to defining the functional roles of phagocytes, but are traditionally identified on a case-by-case basis with technical challenges. As a result, extrinsic regulation of phagocytosis is poorly defined. Here we demonstrate that microglial phagocytosis ligands can be systematically identified by a new approach of functional screening. One of the identified ligands is reticulocalbin-1 (Rcn1), which was originally reported as a Ca2+-binding protein with a strict expression in the endoplasmic reticulum. Our results showed that Rcn1 can be secreted from healthy cells and that secreted Rcn1 selectively bound to the surface of apoptotic neurons, but not healthy neurons. Independent characterization revealed that Rcn1 stimulated microglial phagocytosis of apoptotic but not healthy neurons. Ingested apoptotic cells were targeted to phagosomes and co-localized with phagosome marker Rab7. These data suggest that Rcn1 is a genuine phagocytosis ligand. The new approach described in this study will enable systematic identification of microglial phagocytosis ligands with broad applicability to many other phagocytes.
Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease (2023)

This is the first large-scale cohort study to demonstrate that both VEGF-D plasma levels and VEGFD genetic variants are independently associated with CV outcomes in patients with ACS and CCS. Measurements of VEGF-D levels and/or VEGFD genetic variants may provide incremental prognostic information in patients with ACS and CCS.
Excited Singlet-State Yields in Hydrocarbon Liquids Exposed to X-rays (1997)

The yields of excited singlet states formed in some liquid hydrocarbons are reported for exposure to synchrotron X-rays of energies between 5 and 14 keV. The yields are derived from measurements of ultraviolet fluorescence emission of the hydrocarbons. Results reported are relative to the yield of excited singlets in liquid benzene. The yields decrease with decreasing X-ray energy, and at the lowest energies studied G(1S*) = 1.5/100 eV for cis- and trans-decalin. Results are compared to computer simulations.
ChemInform Abstract: Novel Chiral Precursors of 6‐s‐cis Locked 1α‐25‐Dihydroxyvitamin D3 Analogues Through Selective Enzymatic Acylation. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cerebrospinal Fluid Vasopressin—Changes in Depression (1985)

Cerebrospinal fluid (CSF), thyrotropin releasing hormone (TRH), CSF-vasopressin (AVP), plasma-AVP, CSF-osmolality, plasma-osmolality, CSF-adrenaline (A) and -noradrenaline (NA) were measured in psychiatric patients and controls. Psychiatric patients were classified according to ICD-9 and grouped into endogenous depression, non-endogenous depression, mania and schizophrenia. The depressive groups were classified according to the Newcastle Rating Scale for Depression 1965. Severity of disease was quantified by BRMES, BRMS and BPRS. No difference in CSF-TRH levels was seen among the different diagnostic groups and controls. A positive correlation between CSF-TRH and CSF-A was demonstrated. CSF-AVP concentrations were significantly lowered in both endogenous and non-endogenous depression; no correlation with CSF-A or -NA was seen. Neither did any difference between plasma levels of AVP, plasma-osmolality or CSF-osmolality appear among the groups investigated.
Modern approaches for determination and identification of barrenwort (Epimedium) flavonoids (2016)

The modern methods of analysis of the main active substances barrenwort (Epimedium)—flavonoids—are considered. Various types of extraction are used to isolate these components from plant raw materials. Flavonoids are separated by capillary electrophoresis, thin layer chromatography, and high performance liquid chromatography (HPLC) in combination with UV and mass spectrometric detection.
System Identification of Quasi-static Foam Behavior and its Application in H-point Prediction (2003)

&lt;div class="htmlview paragraph"&gt;Hip joint location (H-point) is an important design specification used by car seat manufacturers. Since most of the modern car seats are full-foam seats, the H-point location is primarily dependent on the quasi-static behavior of foam which is a highly nonlinear and viscoelastic material. In this work, a constitutive model is developed for flexible polyurethane foam. The stiffness characteristics of foam are described by a polynomial in displacement and the viscoelastic behavior is described by a convolution of the response with a kernel which is assumed to be a sum of exponentials. A system identification procedure, based on linear least squares fitting and ARMA modeling, is developed to identify the parameters from data collected in quasi-static foam experiments. Once identified, these models of foam are incorporated into two dimensional multi-degree-of-freedom seat occupant models to determine the static equilibrium position of an occupant in a seat from which the H-point location is determined. A graphical user interface is developed to facilitate study of the influence of changes in system parameters and also to visualize the settling of the occupant in the seat.&lt;/div&gt;
Skill-based telemanipulation by means of intelligent robots (2010)

In order to enable robots to execute highly dynamic tasks in dangerous or remote environments, a semiautomatic teleoperation concept has been developed and will be presented in this paper. It relies on a modular software architecture, which allows intuitive control over the robot and compensates latency-based risks by using Augmented Reality techniques together with path prediction and collision avoidance to provide the remote user with visual feedback about the tasks and skills that will be executed. Based on this architecture different skills with high dynamics are integrated in the robot control, so that they can be executed autonomously without the delayed feedback of the user. The skill-based grasping by adherence of smooth or fragile objects during a remote controlled picking and placing task will be exemplary presented.
Biosafety of Vibrio Parahaemolyticus Biofilm From Seafood Using Herbs and Spices (2013)

The microbial safety of foods continues to be a main concern to consumer, regulatory agencies and food industries around the world. In this study, a total of 394 presumptive vibrios from seafood samples (n=394) consists of cockles (Anadara granosa) ,clams (Mya arenaria), (shrimp) Penaeous spp. and (squid) Loligo opalescens have been isolated. Polymerase chain reaction revealed the 9.14% positive toxr gene, 63.8% of the presence of toxin gene V. parahaemolyticus tdh + , 22.2% trh + , and 5.56% of positive isolates possessing both tdh+ and trh+ while pandemics strain was 83.3% . The sixteen resistant isolates toward seven antibiotics were selected for further study in terms of minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Clove (Syzygium aromaticum), star anise (Illicium verum), lemon leaves (Melissa Officinalis) and curry leaves (Murraya koenigii) have been selected from 20 others herbs and spices because of the potential inhibitory activity against the resistant isolates. Time-kill curves were constructed to assess the concentration between bacteriostatic and bactericidal activity of the respective herbs and spices at concentrations ranging from 0 MIC to 8 × MIC. The activity of cloves against biofilm- producing resistant strains also evaluated. The growth of all resistant strains (n=16) including V. parahaemolyticus ATCC 17802 were inhibited by cloves at a concentration of 39.062 µg/ml and was able to kill all resistant strains with a MBC90 at 78.125 µg/ml compared to the others. The time-kill curves demonstrated that the bactericidal endpoint for resistant strain was reached after 30 min of incubation at a antimicrobials concentration of 8 × MIC. The growth of biofilm-producing isolates can be inhibited and eradicated by clove at concentrations of 156.25 µg/ml, 625 µg/ml respectively. Clove has stronger activity against biofilm-producing resistant strains than star anise, lemon Leaves and curry leaves extracts.
Near linear time algorithm to detect community structures in large-scale networks (2007)

Community detection and analysis is an important methodology for understanding the organization of various real-world networks and has applications in problems as diverse as consensus formation in social communities or the identification of functional modules in biochemical networks. Currently used algorithms that identify the community structures in large-scale real-world networks require a priori information such as the number and sizes of communities or are computationally expensive. In this paper we investigate a simple label propagation algorithm that uses the network structure alone as its guide and requires neither optimization of a predefined objective function nor prior information about the communities. In our algorithm every node is initialized with a unique label and at every step each node adopts the label that most of its neighbors currently have. In this iterative process densely connected groups of nodes form a consensus on a unique label to form communities. We validate the algorithm by applying it to networks whose community structures are known. We also demonstrate that the algorithm takes an almost linear time and hence it is computationally less expensive than what was possible so far.
Proving transaction and system-level properties of untimed SystemC TLM designs (2010)

Electronic System Level (ESL) design manages the enormous complexity of todays systems by using abstract models. In this context Transaction Level Modeling (TLM) is state-of-the-art for describing complex communication without all the details. As ESL language, SystemC has become the de facto standard. Since the SystemC TLM models are used for early software development and as reference for hardware implementation their correct functional behavior is crucial. Admittedly, the best possible verification quality can be achieved with formal approaches. However, formal verification of TLM models is a hard task. Existing methods basically consider local properties or have extremely high run-time. In contrast, the approach proposed in this paper can verify “true” TLM properties, i.e. major TLM behavior like for instance the effect of a transaction and that the transaction is only started after a certain event can be proven. Our approach works as follows: After a fully automatic SystemC-to-C transformation, the TLM property is mapped to monitoring logic using C assertions and finite state machines. To detect a violation of the property the approach uses a BMC-based formulation over the outermost loop of the SystemC scheduler. In addition, we improve this verification method significantly by employing induction on the C model forming a complete and efficient approach. As shown by experiments state-of-the-art proof techniques allow proving important non-trivial behavior of SystemC TLM designs.
Santonin. II.1 The Synthesis of New Stereoisomers of Santonin2 (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSantonin. II.1 The Synthesis of New Stereoisomers of Santonin2Yasuo Abe, Tadatsugu Harukawa, Hisashi Ishikawa, Takuichi Miki, Masao Sumi, and Tadashi TogaCite this: J. Am. Chem. Soc. 1956, 78, 7, 1416–1421Publication Date (Print):April 1, 1956Publication History Published online1 May 2002Published inissue 1 April 1956https://pubs.acs.org/doi/10.1021/ja01588a042https://doi.org/10.1021/ja01588a042research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pesticide‐induced Mitochondrial Dysfunction Augments NLRP3 Inflammasome Signaling Pathway in Primary Microglia (2015)

Sustained neuroinflammation, oxidative stress and mitochondrial dysfunction are the key pathophysiological processes of many neurodegenerative diseases, including Parkinson's disease(PD). The resident microglia in the brain are a major source of inflammation. The NLRP3 inflammasome pathway has been recognized as a major contributor of neuroinflammatory insult in CNS. In the present study, we show that neurotoxic pesticide-induced mitochondrial impairment amplifies the NLRP3 inflammasome proinflammatory cascade in primary microglia. Primary mouse microglia treatment with LPS increased NLRP3 and pro-IL1b expression. LPS-primed microglial cells exposed to the pesticide rotenone, a mitochondrial complex 1 inhibitor, enhanced NLRP3 inflammasome activation and cleavage of pro-IL1b,indicating that mitochondrial impairment heightened the proinflammatory response in microglia. Morphological analysis revealed, rotenone significantly increased mitochondrial circularity and solidity in LPS-primed microglia relative to unprimed microglia, indicating augmentation of mitochondrial fission during inflammasome activation.Immunocytochemical studies showed co-localization of NLRP3 with mitochondrial superoxide in rotenone-treated primed microglia but not in non-primed cells. Collectively, our studies demonstrate for the first time that mitochondrial impairment from neurotoxic pesticide can activate NLRP3 inflammasome in microglia,further augmenting proinflammatory events in the brain. Our findings have important implications in the pathogenesis and progression of environmentally-linked PD (ES10586 and NS78247).
The Design, Construction, and Testing of the Optics for a 147-CM Aperture Telescope (1972)

Geodetic optics research for the Air Force Cambridge Research Laboratories (AFCRL) is described. The work consisted mainly of the fabrication of the optical components for a telescope with a 152-cm-diam (60-in.) primary mirror masked down to 147-cm-diam for use by the AFCRL for a lunar ranging experiment. Among the achievements of this contract were the following: completion of the primary and secondary mirrors for a high-quality 147-cm-diam telescope system in eight months from the start of edging the primary; manufacture and testing of a unique center mount for the primary according to an AFCRL design that allowed for a thin-edged and therefore less-massive mirror; and development of a quantitative analysis of the wire test for calculating the departure of the mirror figure from the design figure quickly and accurately after each polishing step. This analysis method in conjunction with a knowledge of polishing rates for given weights and diameters of tools, mirror, and polishing materials should considerably reduce the polishing time required for future large mirrors.
Quantum theory of dispersive electromagnetic modes (1999)

A quantum theory of dispersion for an inhomogeneous solid is obtained, from a starting point of multipolar coupled atoms interacting with an electromagnetic field. The dispersion relations obtained are equivalent to the standard classical Sellmeir equations obtained from the Drude-Lorentz model. In the homogeneous (plane-wave) case, we obtain the detailed quantum mode structure of the coupled polariton fields, and show that the mode expansion in all branches of the dispersion relation is completely defined by the refractive index and the group velocity for the polaritons. We demonstrate a straightforward procedure for exactly diagonalizing the Hamiltonian in one-, two-, or three-dimensional environments, even in the presence of longitudinal phonon-exciton dispersion, and an arbitrary number of resonant transitions with different frequencies. This is essential, since it is necessary to include at least one phonon (IR) and one exciton (UV) mode, in order to represent dispersion in transparent solid media accurately. Our method of diagonalization does not require an explicit solution of the dispersion relation, but relies instead on the analytic properties of Cauchy contour integrals over all possible mode frequencies. When there is longitudinal-phonon dispersion, the relevant group-velocity term is modified so that it only includes the purely electromagnetic part of the group velocity.
A plan for Melbourne's future? (2017)

For every three people resident in Melbourne in 2001, there are now four. Melbourne is growing and changing at a pace unseen in living memory, matching the post-war immigration and baby boom, and arguably only exceeded by its initial emergence as a city in the gold rush boom. Strong international migration combined with net interstate movement into Victoria (even from Sydney!) increased the residents of our vibrant, booming capital by 2.4% last year. This pace of growth is uncommon among comparable 'western' cities. Among the top twenty North American cities, only Dallas and Houston matched this pace. The cosmopolitan magnet of greater New York City (20 million people) increased an average 123,000 per year in 2010-15, compared to Melbourne's 107,000. Our booming urban cousins San Francisco and Vancouver experienced annual growth of 1.5% and 1.4% respectively.