gebhart/patrepeval huggingface dataset:
Influence of the chitosan morphology on the properties of acrylic cements and their biocompatibility (2020)

Acrylic bone cements (ABC) are materials widely used in orthopedics and biomedical applications. Several active compounds have been introduced to ABC formulations to improve their mechanical properties and bifunctionality. In this research, we studied the effect of the addition of chitosan (CS) microspheres and chitosan sheets on ABC formulations. For mechanical performance optimization, the compression strength was taken as a response variable using an extreme vertices mixing design with fraction by weight of CS and poly(methyl methacrylate) (PMMA) as the variable factors. According to the statistical analysis, the control samples (without CS), samples with 7% (wt.) of CS sheets, and samples with 17% (wt.) of CS spheres presented the best compression properties: 90.6 MPa and 95.6 MPa, respectively. The study of these formulations confirmed that CS spheres allow a higher amount of loading on the formulation, maintaining comparable compression strength. By <sup>1</sup>H-NMR, it was observed that the residual monomer was similar in all wording. The hydrolytic degradation assay in simulated body fluid (SBF) determined that the sphere incorporation increased by 50% and 35% for the water uptake and weight loss values, respectively, when compared with the reported values with CS sheets. By morphological analysis <i>via</i> SEM, it was observed that the porosity increased considerably in the presence of CS spheres throughout the immersion time in SBF. The subdermal implant results demonstrated excellent compatibility between the cement studied and the biological environment.
Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling (2014)

Tissue reinnervation following trauma, disease, or transplantation often presents a significant challenge. Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice. Nerve growth factor (NGF) and glial-derived neurotrophic factor (GDNF) mediated VEGF-induced axonal regeneration, and the expression of both is induced by VEGF presentation. Using both in vitro and in vivo modeling approaches, we demonstrate that the activity of NGF and GDNF regulates VEGF-driven angiogenesis, controlling endothelial cell sprouting and blood vessel maturation. Altogether, these studies produce evidence of new mechanisms of VEGF action, further broaden the understanding of the roles of NGF and GDNF in angiogenesis and axonal regeneration, and suggest approaches to improve axonal and ischemic tissue repair therapies.
Serine/Arginine-Rich Splicing Factor 3 and Heterogeneous Nuclear Ribonucleoprotein A1 Regulate Alternative RNA Splicing and Gene Expression of Human Papillomavirus 18 through Two Functionally Distinguishable cis Elements (2016)

Expression of HPV18 genes is regulated by alternative RNA splicing of viral polycistronic pre-mRNAs to produce a repertoire of viral early and late transcripts. RNA cis elements and trans-acting factors contributing to HPV18 alternative RNA splicing have been discovered in this study for the first time. The identified ESS at the E7 open reading frame (ORF) prevents HPV18 233^416 splicing in the E6 ORF through interaction with a host splicing factor, hnRNP A1, and regulates E6 and E7 expression of the early E6E7 polycistronic pre-mRNA. The identified ESE at the E1^E4 ORF promotes HPV18 929^3434 splicing of both viral early and late pre-mRNAs and E1^E4 production through interaction with SRSF3. This study provides important observations on how alternative RNA splicing of HPV18 pre-mRNAs is subject to regulation by viral RNA cis elements and host splicing factors and offers potential therapeutic targets to overcome HPV-related cancer.
Not Afraid of the Dark: NIR-VIS Face Recognition via Cross-spectral\n Hallucination and Low-rank Embedding (2016)

Surveillance cameras today often capture NIR (near infrared) images in\nlow-light environments. However, most face datasets accessible for training and\nverification are only collected in the VIS (visible light) spectrum. It remains\na challenging problem to match NIR to VIS face images due to the different\nlight spectrum. Recently, breakthroughs have been made for VIS face recognition\nby applying deep learning on a huge amount of labeled VIS face samples. The\nsame deep learning approach cannot be simply applied to NIR face recognition\nfor two main reasons: First, much limited NIR face images are available for\ntraining compared to the VIS spectrum. Second, face galleries to be matched are\nmostly available only in the VIS spectrum. In this paper, we propose an\napproach to extend the deep learning breakthrough for VIS face recognition to\nthe NIR spectrum, without retraining the underlying deep models that see only\nVIS faces. Our approach consists of two core components, cross-spectral\nhallucination and low-rank embedding, to optimize respectively input and output\nof a VIS deep model for cross-spectral face recognition. Cross-spectral\nhallucination produces VIS faces from NIR images through a deep learning\napproach. Low-rank embedding restores a low-rank structure for faces deep\nfeatures across both NIR and VIS spectrum. We observe that it is often equally\neffective to perform hallucination to input NIR images or low-rank embedding to\noutput deep features for a VIS deep model for cross-spectral recognition. When\nhallucination and low-rank embedding are deployed together, we observe\nsignificant further improvement; we obtain state-of-the-art accuracy on the\nCASIA NIR-VIS v2.0 benchmark, without the need at all to re-train the\nrecognition system.\n
Novel health monitoring method using an RGB camera (2017)

In this paper we present a novel health monitoring method by estimating the heart rate and respiratory rate using an RGB camera. The heart rate and the respiratory rate are estimated from the photoplethysmography (PPG) and the respiratory motion. The method mainly operates by using the green spectrum of the RGB camera to generate a multivariate PPG signal to perform multivariate de-noising on the video signal to extract the resultant PPG signal. A periodicity based voting scheme (PVS) was used to measure the heart rate and respiratory rate from the estimated PPG signal. We evaluated our proposed method with a state of the art heart rate measuring method for two scenarios using the MAHNOB-HCI database and a self collected naturalistic environment database. The methods were furthermore evaluated for various scenarios at naturalistic environments such as a motion variance session and a skin tone variance session. Our proposed method operated robustly during the experiments and outperformed the state of the art heart rate measuring methods by compensating the effects of the naturalistic environment.
Pilot study of SGN-15 immunoconjugate with docetaxel as first line therapy for NSCLC with PET assessment of response (2005)

7299 Background: NSCLC cells express tumor antigens, including Lewis Υ (Ley). SGN-15 is a novel antibody-drug conjugate that delivers doxorubicin to cells expressing Ley and has synergistic activity with docetaxel (Doc) based on cell cycle specificity. A randomized phase II study in second and third line NSCLC showed promising activity of SGN-15+Doc. Preclinical studies show that the sequence of SGN-15+Doc can be adjusted to maximize activity and form the basis for this pilot front-line study to optimize the schedule of SGN-15+Doc in NSCLC patients. PET scans provide early assessment of response. Methods: 30 patients with stage IV NSCLC, PS<3 and no prior chemotherapy will receive SGN-15 200 mg/m2 + Doc 35 mg/m2 weekly for three of each four weeks. Arm A receives SGN-15 followed by Doc on day 1, 8, 15 of a 28-day cycle. Arm B receives SGN-15 on the same schedule, but Doc on days 4, 11, 18. PET scans are performed within one week prior to day 1 and on day 22 of cycle 1. Responding or stable patients continue on study until progression or unacceptable toxicity. Response by RECIST is assessed every 8 weeks. No dose reductions or delays are permitted in cycle 1. Primary endpoint is quantitative PET response. Secondary endpoints are ORR, PFS, OS, toxicity, PK and molecular correlates. Results: Mouse studies demonstrate five fold increase in response when SGN-15 is combined with Doc compared to Doc alone and an additional 37% improvement when SGN-15 precedes Doc as opposed to an 18% decrease when the opposite sequence is employed. 7 patients have been enrolled to date on the clinical trial and preliminary PET data suggest a more profound metabolic effect in patients on Arm B compared to Arm A. Conclusion: Combination targeted therapy with SGN-15+Doc is feasible in front-line treatment of NSCLC and PET can be used as an early estimate of efficacy. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Seattle Genetics Seattle Genetics Seattle Genetics Seattle Genetics Seattle Genetics
In Silico Identification and Molecular Validation of Putative Antimicrobial Peptides for HIV Therapy (2016)

Objective: Despite the effort to reduce the rate of HIV infection, AIDS still remains the major cause of death around the world, predominantly in Sub-Sahara Africa. Neither a cure, nor an HIV vaccine has been found to date and the disease can only be managed by using High Active Antiretroviral Therapy (HAART). The need for non-toxic regiments has brought about the necessity for additional HIV treatment to lower mortality rates. Antimicrobial Peptides (AMPs) had proven to be a promising therapeutic agent against HIV. The aim of this research was to identify AMPs, which binds gp120 at the area where gp120 interacts with CD4+, to prevent HIV invasion and HIV replication.
Manganese Cycling in the Oceans (2019)

Abstract Manganese (Mn) is an essential element for life. Although its concentration is at (sub)nanomolar levels throughout the ocean, it affects the oxygen concentration of the ocean because it is central to the photosynthetic formation of dioxygen, O 2 , in photosystem center II. Mn inputs into the ocean are from atmospheric transport of particles and their dissolution to form dissolved Mn, and from the flux of dissolved Mn from rivers, sediments, and hydrothermal vents. The main removal mechanism is transport of particulate Mn from dust and organic matter to the sediments. The environmental chemistry of manganese centers on its +2, +3, and +4 oxidation states. Most recent data show that Mn(II) is dissolved, that Mn(IV) is particulate MnO 2 , and that Mn(III) can be particulate or dissolved when bound to organic complexes [denoted as Mn(III)‐L]. Mn(II) is oxidized primarily by microbial processes whereas MnO 2 is reduced by abiotic and biotic processes. Photochemical processing aids redox cycling in surface waters. In suboxic zones, which are defined as areas where both dissolved O 2 and H 2 S concentrations are below 3 μM, both oxidation and reduction processes can occur but usually at different depths. In suboxic zones, dissolved Mn is also released from organic matter during its decomposition and from MnO 2 reduction.
Overexpression of Superoxide Dismutase or Glutathione Peroxidase Protects against the Paraquat + Maneb-induced Parkinson Disease Phenotype (2005)

Oxidative stress has been implicated in the pathogenesis of Parkinson disease based on its role in the cascade of biochemical changes that lead to dopaminergic neuronal death. This study analyzed the role of oxidative stress as a mechanism of the dopaminergic neurotoxicity produced by the combined paraquat and maneb model of the Parkinson disease phenotype. Transgenic mice overexpressing either Cu,Zn superoxide dismutase or intracellular glutathione peroxidase and non-transgenic mice were exposed to saline, paraquat, or the combination of paraquat + maneb twice a week for 9 weeks. Non-transgenic mice chronically exposed to paraquat + maneb exhibited significant reductions in locomotor activity, levels of striatal dopamine and metabolites, and dopaminergic neurons in the substantia nigra pars compacta. In contrast, no corresponding effects were observed in either Cu,Zn superoxide dismutase or glutathione peroxidase transgenic mice. Similarly, the increase in levels of lipid hydroperoxides in the midbrain and striatum of paraquat + maneb-treated non-transgenic mice was not detected in either Cu,Zn superoxide dismutase or glutathione peroxidase transgenic mice. To begin to determine critical pathways of paraquat + maneb neurotoxicity, the functions of cell death-inducing and protective mechanisms were analyzed. Even a single injection of paraquat + maneb in the non-transgenic treated group modulated several key pro- and anti-apoptotic proteins, including Bax, Bad, Bcl-xL, and upstream stress-induced cascade. Collectively, these findings support the assertion that protective mechanisms against paraquat + maneb-induced neurodegeneration could involve modulation of the level of reactive oxygen species and alterations of the functions of specific signaling cascades.
Limitations of 1D TEM Inversion over 2D Structure (2002)

PreviousNext No AccessSymposium on the Application of Geophysics to Engineering and Environmental Problems 2002Limitations of 1D TEM Inversion over 2D StructureAuthors: David SchaperDavid AlumbaughDavid SchaperGeological Engineering Program, University of Wisconsin‐Madison and David AlumbaughGeological Engineering Program, University of Wisconsin‐Madisonhttps://doi.org/10.4133/1.2927074 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract Introductory paragraph for this paper is available only in the PDF and GZipped PS filesPermalink: https://doi.org/10.4133/1.2927074FiguresReferencesRelatedDetails Symposium on the Application of Geophysics to Engineering and Environmental Problems 2002ISSN (online):1554-8015Copyright: 2002 Pages: publication data© 2002 Copyright © 2002 The Environmental and Engineering Geophysical SocietyPublisher:Environmental & Engineering Geophysical Society HistoryPublished: 30 Sep 2008 CITATION INFORMATION David Schaper and David Alumbaugh, (2002), "Limitations of 1D TEM Inversion over 2D Structure," Symposium on the Application of Geophysics to Engineering and Environmental Problems Proceedings : EEM3-EEM3. https://doi.org/10.4133/1.2927074 Plain-Language Summary PDF DownloadLoading ...
The new Metals and Alloys Indexes -- Search Manual: A phase diagram research tool (1993)

A new Metals and Alloys (M&A) Indexes to the Powder Diffraction File (PDF) has been developed. These indexes will be immediately useful to material scientists because the indexes share many features with references such as Hansen, Elliot, Shunk, Pearson, and Villars and Calvert. These indexes, as contained in the Search Manual, may be used independently or in conjunction with the Powder Diffraction File. The book contains four indexes: two contain data for all materials in the M&A PDF, and two contain supporting data. The permuted-sort Alphabetical Formula Index brings together all entries containing a given element in alphabetical formula order. It has n entries for an n-component material and a straight-line format for the element being sorted to simplify reading the index. Thus, chemical knowledge can make identifications easier. Further, within binary and ternary phase diagrams, phases are listed in compositional order to facilitate direct use in phase diagram research. The Pearson Symbol Code Index has entries arranged in order of the Pearson Symbol Code, hence one can find all the materials with a given structure, and if desired, compare their atomic contents and lattice parameters. The latter are in the standard Crystal Data setting to aid in structural comparisons. The Common Names Index cross-references common metallurgical names, such as austenite or cementite, to the appropriate PDF data. The Strukturbericht Symbol Index cross-references Strukturbericht Symbols and the equivalent Pearson Symbols and Structure Prototypes. Examples of the uses of this index in phase diagram research are given.
Paper-based devices as new smart analytical tools for sustainable detection of environmental pollutants (2021)

The use of paper as a multifunctional material in electrochemical sensing has been intensively explored over the last decade. The combination among different kinds of paper as well as their coupling with different electrochemical cell configurations have been demonstrated, disclosing innovative sensing performances and features that are still to be fully investigated. This ongoing research has found applications in a variety of fields, including the biomedical, agri-food, security, and environmental ones, thanks to the high versatility and adaptability of the paper material. In this review, we report a critical and comparative analysis of electrochemical devices based on paper published within 2010–2021 and applied for the detection of pollutants of environmental interest in fresh water, seawater, and other real environmental matrices. Several paper types, from common office paper to Whatman filter paper with different filtering grades, were proved to be useful in this field. In detail, the multifarious roles played by the paper are discussed, highlighting how the paper can be a suitable material for electrochemical sensing while being capable of simplifying the measurement of complex real matrices or realizing programmable origami-like structures. Among the most important pollutants, a special focus is dedicated to the emerging pollutants. Furthermore, the unique advantages achieved by the paper have been analyzed and highlighted, reporting the future perspectives regarding the use of this surprising material.
ZnO as an effective fluorescence sensor for nitroaromatic derivatives (2013)

International audience
Giant duodenal ulcer: the hepatic intra-arterial chemotherapy variant (1988)

Giant duodenal ulcers are extensive ulcers, more than 2.5 cm in diameter, that involve a large portion of the duodenal bulb. These atypical duodenal ulcers create serious problems to the patient and the physician, are frequently complicated by bleeding and penetration, and have a high mortality rate. Most of the reported cases were classified as a severe variant of the common peptic ulcer disease, others were associated with the Zollinger Ellison syndrome. We report here four patients with giant duodenal ulcers but with a different and definitive aetiology: hepatic intra-arterial chemotherapy infusion for liver metastase or primary hepatocellular carcinoma.
Potential of process information transfer along the process chain of hybrid components for process monitoring of the cutting process (2021)

Abstract The production of hybrid components involves a long process chain, which leads to high investment costs even before machining. To increase process safety and process quality during finishing, it is necessary to provide information about the semi-finished parts geometry for the machining process and to identify defect components at an early stage. This paper presents an investigation to predict variations in dimension and cavities inside the material during cross-wedge rolling of shafts based on measured tool pressure. First, the process is investigated with respect to the variation in diameter for three roll gaps and two materials. Subsequently, features are generated from the hydraulic pressures of the tools and multi-linear regression models are developed in order to determine the resulting diameters of the shaft shoulder. These models show better prediction accuracy than models based on meta-data about set roll gap and formed material. The features are additionally used to successfully monitor the process with regard to the Mannesmann effect. Finally, a sensor concept for a new cross-wedge rolling machine to improve the prediction of the workpiece geometry and a new approach for monitoring machining processes of workpieces with dimensional variations are presented for upcoming studies.
Dihydropyridines in synthesis and biosynthesis. I. Secodine and precursors of dehydrosecodine (1979)

A synthesis of 16,17-dihydrosecodin-17-ol and of secodine is described. Various indole derivatives were elaborated to a series of pyridinium salts, potential precursors for 1,2- and 1,6-dihydropyridine compounds exemplifying the proposed biointermediate 'dehydrosecodine.'
A Hybrid Hopfield Network-Simulated Annealing approach to Optimize Routing Processes in Telecommunications Networks (2007)

This article proposes a new hybrid technique to optimize an intelligent routing algorithm in telecommunications based on Hopfield Neural Networks (HNN) and Simulated Annealing (SA). The SA obtains the optimal parameters for Hopfield Neural Networks. The optimization was carried out considering as performance criterion a combination of (1) the error of the HNN routing algorithm as applied to find the shortest path between two nodes, and (2) the number of iterations employed by the HNN algorithm to find the shortest path. By using this approach better results have been achieved, with lower number of iterations and smaller error rates.
Preparation of Long Conjugated Porphyrin Polymers with Gold Nanoparticles at Both Ends as Electronic and/or Photonic Molecular Wires (2009)

Abstract Nanocomposites of long conjugated porphyrin polymers with both ends substituted by gold nanoparticles were prepared by mixing a polymer bearing thiol groups at both ends with gold nanoparticles protected by 2-methylundecane-2-thiol. The nanocomposites were observed by atomic force microscopy (AFM), which showed that the gold nanoparticles were attached at the terminal positions of the porphyrin polymers as expected from height analyses. The height at the terminal position was ca. 3–4 nm and that at the center position was ca. 2 nm. The nanocomposites could be dispersed homogeneously on solid surfaces such as HOPG or glass substrates using a pulse injection method under high vacuum.