gebhart/patrepeval huggingface dataset:
IFN-λ: A New Inducer of Local Immunity against Cancer and Infections (2016)

IFN-λ is the newly established type III IFN with unique immunomodulatory functions. In contrast to the IFN-α/β family and to some extent IFN-γ, IFN-λ is apparently acting in specific areas of the body to activate resident immune cells and induces a local immunity, instrumental in preventing particular infections and also keeping transformed cells under control. Mucosal areas of lung and gastrointestinal tracts are now under scrutiny to elucidate the immune mechanisms triggered by IFN-λ and leading to viral protection. New evidence also indicates the crucial role of IFN-λ in promoting innate immunity in solid cancer models. Based on its unique biological activities among the IFN system, new immunotherapeutic approaches are now emerging for the treatment of cancer, infection, and autoimmune diseases. In the present review, we highlight the recent advances of IFN-λ immunomodulatory functions. We also discuss the perspectives of IFN-λ as a therapeutic agent.
High-Efficiency of Narrow-Width MOS Capacitor Type Si Optical Modulator with TM Mode Excitation (2019)

We developed a high speed and high efficiency of a narrow-width metal-oxide-semiconductor (MOS) capacitor type Si optical modulator (Si-MOD) by applying TM optical mode excitation. We designed and fabricated the mode-converter from TE to TM mode for MOS capacitor type Si-MOD. Even in case of 200-nm width rib-waveguide, Si MOS-MOD with TM mode showed high-modulation efficiency of 0.17 Vcm and smaller electrical capacitance with decrease in MOS junction width. We also demonstrated 40 Gbps operation for 30–60 μm-long Si MOS-MOD with TM mode.
[Effect of a new fermented soy milk product on serum lipid levels in normocholesterolemic adult men]. (2003)

This study was undertaken to verify the effect of a daily intake of a new fermented soy milk produced with Enterococcus faecium and Lactobacillus jugurti on the serum lipid levels in normocholesterolemic middle-aged men. The study was randomized, double-blind and placebo-controlled and was performed for a period of 6 weeks. Forty-four normocholesterolemic healthy, male volunteers, aged 40-55 years old were randomly separated in two groups: The F-group received 200 ml of the fermented product daily and the P-group received 200 ml of placebo (chemically fermented). The blood samples were drawn initially and after 3 and 6 weeks and serum values for total cholesterol, HDL-cholesterol and triglyceride were determined. The LDL-cholesterol value was estimated. No significant changes in the fermented group (F) were observed for total cholesterol, LDL-cholesterol or triglyceride levels, while the HDL-cholesterol level was significantly higher (p < or = 0.05) after 6 weeks. The total cholesterol and LDL-cholesterol levels were significantly higher (p < or = 0.05) in the placebo group (P), but no changes were found for the HDL-cholesterol and triglyceride levels during the experimental period. In conclusion, the intake of 200 ml/day of the fermented soy milk, produced with E. faecium and L. jugurti, for 6 weeks, did not affect the serum total cholesterol and LDL-cholesterol, and led an increase of 10% in the HDL-cholesterol level.
Morningglory (Ipomoeaspp.) and Large Crabgrass (Digitaria sanguinalis) Control with Glyphosate and 2,4-DB Mixtures in Glyphosate-Resistant Soybean (Glycine max)1 (2001)

Glyphosate effectively controls most weeds in glyphosate-resistant soybean. However, it is sometimes only marginally effective on Ipomoea spp. A field experiment was conducted at five locations in North Carolina to determine the effects of mixing 2,4-DB with glyphosate on Ipomoea spp. control and on soybean injury and yield. The isopropylamine salt of glyphosate at 560, 840, and 1,120 g ai/ha controlled mixtures of tall morningglory, entireleaf morningglory, and red morningglory at least 96% at two locations. Mixing the dimethylamine salt of 2,4-DB at 35 g ae/ha with glyphosate did not increase control but reduced soybean yield 6%. At two other locations, 2,4-DB increased control of tall morningglory and a mixture of entireleaf morningglory and ivyleaf morningglory 13 to 22% when mixed with glyphosate at 560 g/ha, but not when mixed with glyphosate at 840 or 1,120 g/ha. Soybean yield was reduced 31% at one location and was unaffected at the other. At the fifth location, 2,4-DB increased control of tall morningglory 25, 11, and 7% when mixed with glyphosate at 560, 840, and 1,120 g/ha, respectively. Soybean yield was increased 15%. In separate field experiments, glyphosate at 560, 840, and 1,120 g/ha controlled large crabgrass at least 99%. Mixing 2,4-DB at 35 g/ha with glyphosate did not affect control. In the greenhouse, mixing 2,4-DB at 35, 70, 140, or 280 g/ha with glyphosate at 70 to 560 g/ha did not affect large crabgrass control by glyphosate.Nomenclature: Glyphosate; 2,4-DB; entireleaf morningglory, Ipomoea hederacea var. integriuscula Gray #3 IPOHG; ivyleaf morningglory, Ipomoea hederacea (L.) Jacq. # IPOHE; large crabgrass, Digitaria sanguinalis (L.) Scop. # DIGSA; red morningglory, Ipomoea coccinea L. # IPOCC; tall morningglory, Ipomoea purpurea (L.) Roth # PHBPU; soybean, Glycine max (L.) Merr. ‘Hartz 5566 RR’.Additional index words: Herbicide combinations, herbicide interactions, herbicide-resistant crops.Abbreviations: WAT, weeks after treatment.
A Pan-HPV Vaccine Based on Bacteriophage PP7 VLPs Displaying Broadly Cross-Neutralizing Epitopes from the HPV Minor Capsid Protein, L2 (2011)

VLP-display of a cross-neutralizing HPV L2 epitope is an effective approach for inducing high-titer protective neutralizing antibodies and is capable of offering protection from a spectrum of HPVs associated with cervical cancer as well as genital and cutaneous warts.
Mesopolysaccharides: The extracellular surface layer of visceral organs (2020)

The mesothelium is a dynamic and specialized tissue layer that covers the somatic cavities (pleural, peritoneal, and pericardial) as well as the surface of the visceral organs such as the lung, heart, liver, bowel and tunica vaginalis testis. The potential therapeutic manipulation of visceral organs has been complicated by the carbohydrate surface layer-here, called the mesopolysaccharide (MPS)-that coats the outer layer of the mesothelium. The traditional understanding of MPS structure has relied upon fixation techniques known to degrade carbohydrates. The recent development of carbohydrate-preserving fixation for high resolution imaging techniques has provided an opportunity to re-examine the structure of both the MPS and the visceral mesothelium. In this report, we used high pressure freezing (HPF) as well as serial section transmission electron microscopy to redefine the structure of the MPS expressed on the murine lung, heart and liver surface. Tissue preserved by HPF and examined by transmission electron microscopy demonstrated a pleural MPS layer 13.01±1.1 um deep-a 100-fold increase in depth compared to previously reported data obtained with conventional fixation techniques. At the base of the MPS were microvilli 1.1±0.35 um long and 42±5 nm in diameter. Morphological evidence suggested that the MPS was anchored to the mesothelium by microvilli. In addition, membrane pits 97±17 nm in diameter were observed in the apical mesothelial membrane. The spatial proximity and surface density (29±4.5%) of the pits suggested an active process linked to the structural maintenance of the MPS. The striking magnitude and complex structure of the MPS indicates that it is an important consideration in studies of the visceral mesothelium.
Neuartige Imidazoline und ihre Derivate aus Fettsäuren und Hydroxyalkylaminen (1980)

Abstract Aus end‐ sowie innenständigen Olefinen erhaltene Epoxide wurden mit Ethylendiamin zu N‐(vic.‐Hydroxyalkyl)‐ethylendiaminen umgesetzt und mit Fettsäuren bzw. aromatischen oder aliphatischen Mono‐ und Dicarbonsäuren zu 2‐Imidazolinen kondensiert. Durch Quaternierung der 2‐Imidazoline erhält man Imidazoliniumsalze, die in Abhängigkeit von ihrer Struktur ausgeprägte mikrobicide Wirkung zeigen und darüber hinaus auch als Avivagemittel für textiles Material Interesse beanspruchen.
Radioanalytical Chemistry for Automated Nuclear Waste Process Monitoring (2004)

This research program is directed toward rapid, sensitive, and selective determination of beta and alpha-emitting radionuclides such as 99Tc, 90Sr, and trans-uranium (TRU) elements in low activity waste (LAW) processing streams. The overall technical approach is based on automated radiochemical measurement principles, which entails integration of sample treatment and separation chemistries and radiometric detection within a single functional analytical instrument. Nuclear waste process streams are particularly challenging for rapid analytical methods due to the complex, high-ionic-strength, caustic brine sample matrix, the presence of interfering radionuclides, and the variable and uncertain speciation of the radionuclides of interest. As a result, matrix modification, speciation control, and separation chemistries are required for use in automated process analyzers. Significant knowledge gaps exist relative to the design of chemistries for such analyzers so that radionuclides can be quantitatively and rapidly separated and analyzed in solutions derived from low-activity waste processing operations. This research is addressing these knowledge gaps in the area of separation science, nuclear detection, and analytical chemistry and instrumentation. The outcome of these investigations will be the knowledge necessary to choose appropriate chemistries for sample matrix modification and analyte speciation control and chemistries for rapid and selective separation and preconcentration of target radionuclides from complex sample matrices. In addition, new approaches for quantification of alpha emitters in solution using solid-state diode detectors, as well as improved instrumentation and signal processing techniques for use with solid-state and scintillation detectors, will be developed. New knowledge of the performance of separation materials, matrix modification and speciation control chemistries, instrument configurations, and quantitative analytical approaches will provide the basis for designing effective instrumentation for radioanalytical process monitoring. Research Progress and Implications
Wnt/&#946;-Catenin Signaling in Alzheimer’s Disease (2014)

Alzheimer's disease is a neurodegenerative disorder that causes a progressive decline of mental and cognitive processes such as memory, judgment and reasoning. We proposed earlier that a sustained loss of function of Wnt/β- catenin signaling components underlies the onset and progression of the disease. Here, we discuss recent data on the involvement of Wnt/b-catenin signaling on amyloid precursor protein (APP) processing, Aβ peptide neurotoxicity, τ phosphorylation, and modulation of Apolipoprotein E function in the brain. We conclude that several components of the cascade are actively engaged in the events leading to AD neuropathology and propose that compounds that mimic activation of this signaling cascade, such as lithium, should be considered for therapeutic intervention in Alzheimer's patients. In summary, data accumulated during the past decade confirm some important predictions of our hypothesis where components of this signaling cascade are actively engaged in the events leading to AD neuropathology and that compounds that mimic activation of this signaling cascade, such as lithium, should be considered for therapeutic intervention in Alzheimer's patients.
Characterization of Tris(N-substituted-2-methyl-3-hydroxy-4-pyridinonato)technetium(IV) Cations (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of Tris(N-substituted-2-methyl-3-hydroxy-4-pyridinonato)technetium(IV) CationsD. Scott Edwards, Shuang Liu, Michael J. Poirier, Zaihui Zhang, Gordon A. Webb, and Chris OrvigCite this: Inorg. Chem. 1994, 33, 24, 5607–5609Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ic00102a042https://doi.org/10.1021/ic00102a042research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mobilization of bone marrow‐derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration (2006)

The purpose of present study was to evaluate active mobilization effect of mesenchymal stem cells (MSCs) into injured tissues after intraarticular injection of MSCs, and to evaluate their contribution to tissue regeneration. MSCs, which were obtained from green fluorescent protein (GFP) transgenic Sprague-Dawley (SD) rat and cultivated, were injected into normal SD rats in which multiple tissues had been injured including anterior cruciate ligament (ACL), medial meniscus, and articular cartilage of the femoral condyles. At 4 weeks after injection of MSCs, fluorescent microscopic observation, immunohistochemical or histological examinations were performed to evaluate mobilization of MSCs into injured tissue and their contribution to tissue regeneration. In the group of 1 x 10(6) MSCs injection, GFP positive cells could mobilize into the injured ACL alone in all 8 knees. In the group of 1 x 10(7) MSCs injection, GFP positive cells were observed in the injured site of ACL in all 8 knees and in the injured site of medial meniscus and cartilage of femoral condyles in 6 of 8 knees. More interestingly, extracellular matrix stained by toluidine blue was present around GFP positive cells in the injured femoral condyles cartilage and medial meniscus, indicating tissue regeneration. Intraarticularly injected MSCs could mobilize into the injured tissues, and probably contributed to tissue regeneration. This study demonstrated the possibility of intraarticular injection of MSCs for the treatment of intraarticular tissue injuries including ACL, meniscus, or cartilage. If this treatment option is established, it can be minimally invasive compared to conventional surgeries for these tissues.
The Application of Virtual Machines on System Security (2009)

It is very important to protect critical resources such as private data and code in computer systems. It is promising to protect private data and to improve the system security by leveraging the isolation attribute of virtual machine (VM). The isolation attribute of VM is provided by Virtual Machine Monitor (VMM) that runs in higher priority than guest OSes. If the critical components are isolated in VMs,access control can be enforced or attestation can be made when the subject is accessing via VMs. In this way, VMs can improve the security level of critical components such as OS, kernel, data, and applications. For computer system security, VMs can be used to detect malware intrusions and to protect critical components, which can be implemented by integrating detection or protection mechanism in either VMM or VMs. Authentication is required to create trustful VMs. This paper surveys technologies related of using virtual machines to enhance system security.
Remote ex vivo lung perfusion at a centralized evaluation facility (2022)

Remote ex vivo perfusion of lung allografts declined for conventional transplantation at a dedicated CLES facility is feasible and resulted in additional transplants. Recipients of allografts assessed with a CLES had a higher rate of PGD3-72 hours, but similar 30-day and 1-year outcomes compared to conventional lung recipients. (NCT02234128).
Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage (2014)

The tumor suppressor gene p53 regulates apoptosis in response to DNA damage. Promoter selectivity of p53 depends on mainly its phosphorylation. Particularly, the phosphorylation at serine-46 of p53 is indispensable in promoting pro-apoptotic genes that are, however, poorly determined. In the current study, we identified palmdelphin as a pro-apoptotic gene induced by p53 in a phosphorylated serine-46-specific manner. Upregulation of palmdelphin was observed in wild-type p53-transfected cells, but not in serine-46-mutated cells. Expression of palmdelphin was induced by p53 in response to DNA damage. In turn, palmdelphin induced apoptosis. Intriguingly, downregulation of palmdelphin resulted in necroptosis-like cell death via ATP depletion. Upon DNA damage, palmdelphin dominantly accumulated in the nucleus to induce apoptosis. These findings define palmdelphin as a target of serine-46-phosphorylated p53 that controls cell death in response to DNA damage.
cFLIP expression is altered in severe corticosteroid-resistant asthma (2014)

Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice and an exon junction microarray to detect potential changes in alternative splicing. One of the sensitization-associated changes identified in the search was a shift in alternative splicing of the mRNA encoding cFLIP, a modulator of the caspase-mediated extrinsic apoptosis pathway. Expanding these studies to human asthma patients, we discovered a significant decrease in the expression of both cFLIP isoforms in severe corticosteroid-resistant asthmatics. Although it is unclear whether these changes were due solely to differences in alternative splicing, these findings provide evidence that dysregulation of the extrinsic apoptosis pathway is part of the underlying immunopathogenesis of severe refractory asthma.
ChemInform Abstract: An Approach to α‐Substituted Amines. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ultrathin 2D Metal–Organic Framework Nanosheets (2015)

A facile surfactant-assisted bottom-up synthetic method to prepare a series of freestanding ultrathin 2D M-TCPP (M = Zn, Cu, Cd or Co, TCPP = tetrakis(4-carboxyphenyl)porphyrin) nanosheets with a thickness of sub-10 nm is developed. As a proof-of-concept application, some of them are successfully used as new platforms for DNA detection. The Cu-TCPP nanosheet-based sensor shows excellent fluorescent sensing performance and is used for the simultaneous detection of multiple DNA targets.
Different Module's Process Affect to Poly Pattern Etch Stick Particle (2022)

In the semiconductor manufacturing process, because of the backside films' characteristic, some process will produce special defects. Particularly, stick particle is one of the special defects in Poly etch process. This paper will discuss the formation and improvement measures of stick particle through the film materials, process integration and other aspects.
[Construction and application of an Escherichia coli high effective expression vector with an enhancer]. (2000)

In this study, we constructed a high effective fusion expression-vector in E. coli. This vector, pTO-T7, was characterized as: (1) an enhancer from tobacco mosaic virus (TMV), omega sequence, was ligated in front of a T7 promoter in the regulatory sequence; (2) the multi-cloning sites include eight restriction enzyme sites. It can facilitate fusion or nonfusion expression; (3) the N terminal of a fusion protein starts with the first 12 amino acids of T7 gene 10, and the C terminal is the hexahistidine tag; (4) kanmycin resistance gene was used as a selective marker. EGFP gene was inserted into pTO-T7 vector as a reporter gene. Expression data showed that fused-EGFP accounted to more than 50% of the total E. coli protein, and more than 90% of which was soluble. The fluorescence characters of fused-EGFP were also studied. The expression yield of target gene from plasmid pTO-T7 compared with that from pT-T7 without omega sequence suggested that omega sequence in pTO-T7 can improve the expression of target gene significantly.
Ni nanocluster on modified CeO2–ZrO2 nanoporous composite for tri-reforming of methane (2016)

Modified Ni-CeO<sub>2</sub>–ZrO<sub>2</sub> nanoporous catalysts have been synthesized by using a very facile solvothermal approach and urea deposition precipitation method. The catalyst system is highly stable for more than 100 h with almost a constant syngas ratio of 2.1 and &gt;95% methane conversion at 800 °C in the tri-reforming reaction of methane.
Elements of Acoustics. By S. TEMKIN. Wiley, 1981. 515 pp. £15.35. Acoustics: An Introduction to its Physical Principles and Applications. By ALLAN D. PIERCE. McGraw-Hill, 1981. 642 pp. £20.25. (1983)

Elements of Acoustics. By S. TEMKIN. Wiley, 1981. 515 pp. £15.35. Acoustics: An Introduction to its Physical Principles and Applications. By ALLAN D. PIERCE. McGraw-Hill, 1981. 642 pp. £20.25. - Volume 128
Network-Assigned Upstream Label (2018)

This document discusses a Generalized Multi-Protocol Label Switching
(GMPLS) Resource reSerVation Protocol with Traffic Engineering (RSVP-
TE) mechanism that enables the network to assign an upstream label for
a bidirectional Label Switched Path (LSP). This is useful in scenarios
where a given node does not have sufficient information to assign the
correct upstream label on its own and needs to rely on the downstream
node to pick an appropriate label. This document updates RFCs 3471,
3473, and 6205 as it defines processing for a special label value in
the UPSTREAM_LABEL object.
A Systematic Approach for the Solubilization of the Integral Membrane Protein Lysophospholipid (2003)

The lysophospholipid∶acyl-CoA acyltransferase (LAT, EC 2.3.1.23) catalyzes the reacylation of lysophospholipids with coenzyme A-activated fatty acids, and is part of the Lands cycle (). The LAT is an important enzyme participating in the rapid turnover of phospholipids thereby: 1) maintaining the membrane lipid composition and the asymmetrical distribution of unsaturated fatty acids within the phospholipids (for review, see refs. ,), and 2) controlling the free arachidonic acid levels (for review, see ref. ). In addition, LAT is thought to play a crucial role in the early phase of T-cell activation by the elevated incorporation of polyunsaturated fatty acids into plasma membrane phospholipids (,). LAT is suggested to be an integral membrane protein, and it is established that there are separate acyltransferases with different specificity toward both lysophospholipids and acyl-CoAs (,).