gebhart/patrepeval huggingface dataset:
GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils (2017)

Neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau), and related disorders. Pathological tau proteins derived from human AD brains (AD-tau) act as proteopathic seeds that initiate the templated aggregation of soluble tau upon intracerebral injection into tau transgenic (Tg) and wild-type mice, thereby modeling human tau pathology. In this study, we found that aged Tg mice of both sexes expressing human tau proteins harboring a pathogenic P301L <i>MAPT</i> mutation labeled with green fluorescent protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentritic domain of neurons, but these mice did not develop <i>de novo</i> insoluble tau aggregates, which are characteristic of human AD and related tauopathies. However, intracerebral injections of either T40PL preformed fibrils (PFFs) or AD-tau seeds into T40PL-GFP mice induced abundant intraneuronal pathological inclusions of hyperphosphorylated T40PL-GFP. These injections of pathological tau resulted in the propagation of tau pathology from the injection site to neuroanatomically connected brain regions, and these tau inclusions consisted of both T40PL-GFP and WT endogenous mouse tau. Primary neurons cultured from the brains of neonatal T40PL-GFP mice provided an informative <i>in vitro</i> model for examining the uptake and localization of tau PFFs. These findings demonstrate the seeded aggregation of T40PL-GFP <i>in vivo</i> by synthetic PFFs and human AD-tau and the utility of this system to study the neuropathological spread of tau aggregates.<b>SIGNIFICANCE STATEMENT</b> The stereotypical spread of pathological tau protein aggregates have recently been attributed to the transmission of proteopathic seeds. Despite the extensive use of transgenic mouse models to investigate the propagation of tau pathology <i>in vivo</i>, details of the aggregation process such as the early seeding events leading to new tau pathology have remained elusive. This study validates the use of GFP-labeled tau expressed by neurons <i>in vivo</i> and <i>in vitro</i> as models for investigating mechanisms underlying the seeded transmission of tau pathology as well as tau-focused drug discovery to identify disease-modifying therapies for AD and related tauopathies.
Urinary nerve growth factor is a better biomarker than detrusor wall thickness for the assessment of overactive bladder with incontinence (2009)

Abstract Purpose To compare the differences in urinary nerve growth factor (NGF) and detrusor wall thickness (DWT) between patients with overactive bladder (OAB) and controls to evaluate their suitability as biomarkers in OAB. Materials and Methods A total of 81 patients including normal controls (n = 28), patients with OAB dry (n = 28) and OAB wet (n = 25) were enrolled in this study. Videourodynamic study was performed in 79 patients after confirmation of symptomatic classification by 3‐day voiding diary. Urine NGF and DWT measurements were performed at full bladder and urge to void after natural‐filling or catheter‐filling during videourodynamic study. Urinary NGF level was measured by the ELISA method and DWT was measured by trans‐abdominal ultrasound. These two parameters were compared among different symptomatic and urodynamic subgroups. Results DWT was not significantly different among subgroups at 250 ml bladder volume. Although patients with OAB wet had a significantly greater DWT at the maximal bladder volume, this difference was not significant from controls after correction of the volume factor. By contrast, urinary NGF levels were significantly increased in patients with OAB wet and those with urodynamic detrusor overactivity. However, elevated NGF levels in OAB wet were found only after natural‐filling and not after catheter‐filling. Conclusions Urinary NGF level in natural‐filling urine sample is a better biomarker for assessment of OAB wet compared to DWT. Patients with OAB dry or hypersensitive bladder did not have an elevated urinary NGF level. Urine samples from catheter‐filling do not have a detectably high NGF levels. Neurourol. Urodynam. 29:482–487, 2010. © 2009 Wiley‐Liss, Inc.
Effects of Na neutralization level on the SH behaviour after ballistic tests of EMAA based ionomers (2013)

Ethylene-co-methacrylic acid (EMAA) based ionomers have thermo-mechanical properties strongly dependent on neutralization level of acid groups. Research revealed also how these materials are able to heal after ballistic impacts. In order to better understand the role of neutralization level on the Self-Healing (SH) behaviour, mechanical and ballistic tests on EMAA copolymers, neutralized with different amount of Na ions, were performed in different experimental conditions. The SH capability was studied by shooting bullets at low velocity (180 m/s) and mid velocity (400 m/s); different testing conditions such as sample thickness and bullet diameter were examined. In all impact tests, spherical projectiles were used. These experiments allowed to define a critical ratio between sample thickness and bullet diameter below which the SH behaviour does not appear. After ballistic damage, the healing efficiency was evaluated by applying a pressure difference through tested samples. Subsequently, morphology analysis of the impacted areas was made observing all tested samples by Scanning Electron Microscope (SEM). These analysis revealed different characteristic features in the damaged zones of tested polymers impacted at different projectile speed. Obtained results show how the Na ions content influences the SH capability; in particular the EMAA copolymer with the highest Na neutralization level does not show a complete hole closure after low velocity impact test. Conversely, increasing projectile speed, all the polymers exhibit nearly the same SH behaviour.
Genotyping Candida albicans from Candida Leukoplakia and Non-Candida Leukoplakia Shows No Enrichment of Multilocus Sequence Typing Clades but Enrichment of ABC Genotype C in Candida Leukoplakia (2013)

Oral leukoplakias are histopathologically-diagnosed as Candida leukoplakia or non-Candida leukoplakia by the presence or absence of hyphae in the superficial epithelium. Candida leukoplakia lesions have significantly increased malignant potential. Candida albicans is the most prevalent fungal species associated with oral leukoplakia and may contribute to malignant transformation of Candida leukoplakia. To date, no detailed population analysis of C. albicans isolates from oral leukoplakia patients has been undertaken. This study investigated whether specific C. albicans genotypes were associated with Candida leukoplakia and non-Candida leukoplakia in a cohort of Irish patients. Patients with histopathologically-defined Candida leukoplakia (n = 31) or non-Candida leukoplakia (n = 47) were screened for Candida species by culture of oral rinse and lesional swab samples. Selected C. albicans isolates from Candida leukoplakia patients (n = 25), non-Candida leukoplakia patients (n = 19) and oral carriage isolates from age and sex matched healthy subjects without leukoplakia (n = 34) were subjected to multilocus sequence typing (MLST) and ABC genotyping. MLST revealed that the clade distribution of C. albicans from both Candida leukoplakia and non-Candida leukoplakia lesions overlapped with the corresponding clade distributions of oral carriage isolates and global reference isolates from the MLST database indicating no enrichment of leukoplakia-associated clones. Oral leukoplakia isolates were significantly enriched with ABC genotype C (12/44, 27.3%), particularly Candida leukoplakia isolates (9/25, 36%), relative to oral carriage isolates (3/34, 8.8%). Genotype C oral leukoplakia isolates were distributed in MLST clades 1,3,4,5,8,9 and 15, whereas genotype C oral carriage isolates were distributed in MLST clades 4 and 11.
Preface (2006)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPrefaceJoseph J. BozellJoseph J. BozellNational Renewable Energy Laboratory 1617 Cole Boulevard Golden, CO 80401More by Joseph J. Bozell and Martin K. PatelMartin K. PatelUtrecht University Department of Science, Technology and Society (STS)/Copernicus Institute Heidelberglaan 2 NL-3584 CS Utrecht The NetherlandsMore by Martin K. PatelDOI: 10.1021/bk-2006-0921.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):January 12, 2006Publication History Published online23 July 2009Published inprint 12 January 2006Request reuse permissions Copyright © 2006 American Chemical Society. This publication is available under these Terms of Use. Feedstocks for the Futurepp xi-xiiiACS Symposium SeriesVol. 921ISBN13: 9780841239340eISBN: 9780841220393Chapter Views177Citations1LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (320 KB) Get e-Alerts
Chitosan Treatment Delays the Induction of Senescence in Human Foreskin Fibroblast Strains (2015)

Fibroblasts have been extensively used as a model to study cellular senescence. The purpose of this study was to investigate whether the human foreskin fibroblast aging process could be regulated by using the biomaterial chitosan. Fibroblasts cultured on commercial tissue culture polystyrene (TCPS) entered senescence after 55-60 population doublings (PDs), and were accompanied by larger cell shape, higher senescence-associated β-galactosidase (SA β-gal) activity, lower proliferation capacity, and upregulation of senescence-associated molecular markers p21, p53, retinoblastoma (pRB), and p16. Before senescence was reached, PD48 cells were collected from TCPS and seeded on chitosan for three days (PD48-Cd3) to form multicellular spheroids. The protein expression of senescence-associated secretory phenotypes (SASPs) and senescence-associated molecular markers of these cells in PD48-Cd3 spheroids were downregulated significantly. Following chitosan treatment, fibroblasts reseeded on TCPS showed lower SA β-gal activity, increased cellular motility, and a higher proliferation ability of 70-75 PDs. These phenotypic changes were not accompanied by colonies forming in soft agar and a continuous decrease in the senescence-associated proteins p53 and pRB which act as a barrier to tumorigenesis. These results demonstrate that chitosan treatment could delay the induction of senescence which may be useful and safe for future tissue engineering applications.
Abstract 12121: Coronary Disease Association With ADAMTS7 is Due to Protease Activity: Implications for Therapeutic Development (2021)

Background: Despite contemporary therapy, coronary artery disease (CAD) remains a leading cause of mortality. Genetic variants at ADAMTS7 have been associated with CAD and the loss of ADAMTS7 is protective for atherosclerosis. ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin motifs 7) is a secreted metalloproteinase and complex proteoglycan, yet the mechanism linking ADAMTS7 to CAD risk remains unresolved. Methods and Results: We established a new purification strategy for full-length mouse ADAMTS7 and demonstrated the loss of activity in the catalytic mutant form of ADAMTS7. To test if the enzymatic activity of ADAMTS7 mediates atherosclerosis, we generated a catalytically inactive mutant mouse allele and compared it to the Adamts7 knockout. Using two models of atherosclerosis, we found that reducing either ADAMTS7 dosage or catalytic function decreased the burden of atherosclerosis. We demonstrate impaired vascular smooth muscle migration in both Adamts7 catalytic mutant and null cells using a lateral migration wound healing assay. Expression of the WT allele rescued the migration phenotype in Adamts7 null cells while expression of the catalytic mutant protein did not. We then characterized a human ADAMTS7 coding variant rs3825807 (Ser214Pro) associated with reduced CAD risk. This variant had a hypomorphic effect on ADAMTS7 secretion and migration of vascular smooth muscle cells, findings consistent with our mouse studies. Conclusions: We demonstrated that loss of ADAMTS7 catalytic function protects against atherosclerosis via phenotype switch of VSMCs and that the atherosclerosis protective effects could be mediated by a loss-of-function coding variant associated with CAD risk. In aggregate, we provide compelling evidence that dosage of ADAMTS7 and catalytic function are responsible for the atherosclerotic phenotype, suggesting that the catalytic domain would be an attractive therapeutic target for CAD.
Postoperative Pain Management following Bilateral Lung Volume Reduction Surgery for Severe Emphysema (2005)

This study was conducted to audit the clinical management of a continuous local anaesthetic infusion delivered by a fluoroscopically placed thoracic epidural catheter in conjunction with supplemental intravenous opioid patient controlled analgesia for postoperative pain control following bilateral lung volume reduction surgery for severe emphysema. This retrospective case series involved a random sample of 43 patients from a possible 65 patients. The mean dose of epidural bupivacaine 0.15% was 6.7 ml/h (SD 1.5), while the mean daily dose of morphine or hydromorphone was 22.5 mg/day (SD 17.9) and 4.3 mg/day (SD 3.1), respectively. Inadequate analgesia was reported by 19 (44%) patients during the first two postoperative days, but was successfully treated by individual titration of these medications. The incidence of atrial fibrillation (n = 6), premature epidural catheter dislodgement (n=6) or respiratory failure (n=3) appeared to be greater among patients who had inadequate analgesia at some stage. One patient developed excessive sedation; otherwise, there were no major complications. The use of an epidural bupivacaine infusion in conjunction with intravenous opioid patient controlled analgesia proved to be a safe and effective pain medication regimen when accompanied by individual titration of these agents in response to acute exacerbations of postoperative pain.
Important Drift Space Contributions to Non-Linear Beam Dynamics (2021)

This paper presents an in-depth analysis of the non-linear contributions of drift spaces in beam dynamics for the creation of Transverse Resonance Island Buckets (TRIBs). TRIBs have been successfully generated in BESSY II and MLS at the Helmholtz-Zentrum Berlin für Materialien und Energie GmbH (HZB). They offer the possibility of generating a second stable orbit and, by populating the orbit with a different electron bunch pattern, allow to effectively have two distinct radiation sources in the same machine individually tailored to different user needs. We demonstrate the generation of TRIBs by order of non-linearity on simple lattice configurations by only treating the drift space as the non-linear element. Moreover, we also insert other non-linear magnets to show how they modify the already generated TRIBs from the drift spaces. We conclude by giving a qualitative analysis of the occurring effects, which provides a guideline as to when the linear approximation is insufficient and the non-linear contribution has to be taken into account.
Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron (2018)

The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of sqrt[s]=1.96 TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A_{FB}^{tt[over ¯]}=0.128±0.025. The combined inclusive and differential asymmetries are consistent with recent standard model predictions.
Significación del pensamiento y la obra de Manuel Sales y Ferré (1843-1910) (1981)

Do personality traits in highly intelligent individuals relate to their work engagement? Seemingly little is known about the relationship between personality and work engagement for gifted individuals. In what may be the first study to do so, a Swedish Mensa sample (<i>n</i> = 353) was explored with a two-part aim: to assess psychometric personality properties and to investigate the relationship between personality traits (Mini-IPIP6) and work engagement (UWES-9). The results of the Mensa members and the Mturk sample (1.4 SD lower in cognitive ability based on ICAR-16) were compared using a confirmatory factor analysis (CFA) and a regression. The findings indicated that the Mensa sample had higher openness (<i>d</i> = .50) and honesty-humility (<i>d</i> = .65) and that personality traits were similarly related to work engagement in both groups, with the exception that neither openness nor honesty-humility were related to work engagement in the Mensa sample. The characteristics of intellectually gifted individuals are further discussed.
Clinical and angiographic outcome of a single center, real world population treated with a dedicated technique of implantation for bioresorbable vascular scaffolds. The FAtebenefratelli Bioresorbable Vascular Scaffold (FABS) registry (2017)

In a complex, all-comers real world population, BVS implantation with a specific, and standardized technique showed to be feasible, with acceptable mid-term angiographic and long-term clinical outcome.
An Automated Algorithm for Detection of Hydrometeor Returns in Micropulse Lidar Data (1998)

A cloud detection algorithm for a low power micropulse lidar is presented that attempts to identify all of the significant power returns from the vertical column above the lidar at all times. The main feature of the algorithm is construction of lidar power return profiles during periods of clear sky against which cloudy-sky power returns are compared. This algorithm supplements algorithms designed to detect cloud-base height in that the tops of optically thin clouds are identified and it provides an alternative approach to algorithms that identify significant power returns by analysis of changes in the slope of the backscattered powers with height. The cloud-base heights produced by the current algorithm during nonprecipitating periods are comparable with the results of a cloud-base height algorithm applied to the same data. Although an objective validation of algorithm performance on high, thin cirrus is lacking because of no truth data, the current algorithm produces few false positive and false negative classifications as determined through manual comparison of the original photoelectron count data to the final cloud mask image.
Adapting Word Embeddings to New Languages with Morphological and\n Phonological Subword Representations (2018)

Much work in Natural Language Processing (NLP) has been for resource-rich\nlanguages, making generalization to new, less-resourced languages challenging.\nWe present two approaches for improving generalization to low-resourced\nlanguages by adapting continuous word representations using linguistically\nmotivated subword units: phonemes, morphemes and graphemes. Our method requires\nneither parallel corpora nor bilingual dictionaries and provides a significant\ngain in performance over previous methods relying on these resources. We\ndemonstrate the effectiveness of our approaches on Named Entity Recognition for\nfour languages, namely Uyghur, Turkish, Bengali and Hindi, of which Uyghur and\nBengali are low resource languages, and also perform experiments on Machine\nTranslation. Exploiting subwords with transfer learning gives us a boost of\n+15.2 NER F1 for Uyghur and +9.7 F1 for Bengali. We also show improvements in\nthe monolingual setting where we achieve (avg.) +3 F1 and (avg.) +1.35 BLEU.\n
ChemInform Abstract: Intermediates for the Synthesis of Linear Chains of 1,2:4,5‐Fused Cyclohexa‐1,4‐diene Rings and Beltenes by Repeated Diels‐Alder Reactions. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimisation of active suspension control inputs for improved vehicle ride performance (2016)

A collocation-type control variable optimisation method is used in the paper to analyse to which extent the fully active suspension (FAS) can improve the vehicle ride comfort while preserving the wheel holding ability. The method is first applied for a cosine-shaped bump road disturbance of different heights, and for both quarter-car and full 10 degree-of-freedom vehicle models. A nonlinear anti-wheel hop constraint is considered, and the influence of bump preview time period is analysed. The analysis is then extended to the case of square- or cosine-shaped pothole with different lengths, and the quarter-car model. In this case, the cost function is extended with FAS energy consumption and wheel damage resilience costs. The FAS action is found to be such to provide a wheel hop over the pothole, in order to avoid or minimise the damage at the pothole trailing edge. In the case of long pothole, when the FAS cannot provide the wheel hop, the wheel is travelling over the pothole bottom and then hops over the pothole trailing edge. The numerical optimisation results are accompanied by a simplified algebraic analysis.
Studies Related to the Presence of a Gonadotropin-Inhibiting Material in Human Urine (1965)

Suitably prepared extracts of urine of men and children were tested in the mouse uterine weight assay for the presence of an inhibitor of urinary gonadotropin. Attempts to demonstrate a gonadotropin inhibitor prepared from the urine of men and children were unsuccessful except when “inhibitor” exerted a toxic effect on the test animals.
Immunohistochemical assay of neu/c-erbB-2 oncogene product in paraffin-embedded tissues in early breast cancer: retrospective follow-up study of 245 stage I and II cases. (1991)

The expression of neu oncoprotein was assayed by immunohistochemistry (IHC) on 245 paraffin-embedded, Stage I and II breast cancers from patients treated at the City of Hope between the years 1980 and 1987. Only cases showing membrane staining were scored as positive. Fifty-four (22%) of the tumors stained positively for neu. Probability of disease-free survival (DFS) and overall survival (OS) was compared based on neu positivity and other prognostic factors. Overall, DFS and OS did not differ significantly among neu-positive and neu-negative cases. However, when only cases with favorable (Stages I and II) nuclear grade were analyzed, OS and DFS were significantly lower in neu-positive cases, with a 9-fold increase in risk of death and a 3-fold increase in risk of relapse. Our findings suggest that immunohistologic study of neu oncoprotein may help to define patients at greater risk among low-stage/low-nuclear-grade patients with breast cancer, a group hitherto recognized as having a good prognosis.