gebhart/patrepeval huggingface dataset:
Array Comparative Genomic Hybridization of Peripheral Blood Granulocytes of Patients With Myelodysplastic Syndrome Detects Karyotypic Abnormalities (2010)

The diagnosis of myelodysplastic syndromes (MDSs) relies largely on morphologic and karyotypic abnormalities, present in about 50% of patients with MDS. Array-based genomic platforms have identified copy number alterations in 50% to 70% of bone marrow samples of patients with MDS with a normal karyotype, suggesting a diagnostic role for these platforms. We investigated whether blood granulocytes harbor the same copy number alterations as the marrow of affected patients. Of 11 patients, 4 had cytogenetic abnormalities shown by conventional karyotyping involving chromosomes 5, 8, 11, 20, and X, and these changes were seen in the granulocytes of all 4 patients by using array comparative genomic hybridization (aCGH). Cryptic alterations were identified at a significantly higher level in marrow CD34+ cells compared with granulocytes (P < .0001). These data suggest that aCGH analysis of circulating granulocytes may be useful in detecting gross karyotypic alterations in patients with MDS when marrow examination has failed or not been done.
Dysregulated ENPP1 increases the malignancy of human lung cancer by inducing epithelial-mesenchymal transition phenotypes and stem cell features. (2019)

Induction of cancer stem cell (CSC) characters and epithelial mesenchymal transition (EMT) features are crucial in tumor initiation, progression and metastasis. However, underlying mechanisms remain incompletely understood. Here, we showed that ENPP1 plays an important role in inducing and maintaining EMT phenotypes and CSC features in lung cancer. ENPP1 is upregulated in lung cancer cells. ENPP1-knockdown in lung cancer HCC827 cells and A549 cells resulted in suppressed colonogenic formation, anchorage-independent growth in vitro, and tumorigenicity in vivo. ENPP1-knockdown also reduced expression of CSC makers, including ABCG2, SOX2, NANOG, and CD44. Moreover, ENPP1-knockdown reversed TGFβ-induced EMT phenotypes, including cell migration, E-cadherin repression and vimentin induction. Finally, upregulated ENPP1 was identified in majority of human lung tumor tissues compared to adjacent normal lung tissues. Taken together, our study demonstrates that dysregulated ENPP1 contributes to increased malignancy of human lung cancer by inducing CSC-features, and EMT-like phenotypes.
Research Note: Ultraviolet Irradiation (UVB) Interrupts Calcium Cell Signaling in Lens Epithelial Cells (1999)

Abstract— A preliminary study was undertaken to establish whether low‐dose UV irradiation (UVB) affects calcium cell signaling in rabbit lens epithelia. In a suspension of lens epithelial cells (line NN1003A), changes in intracellular Ca 2+ were measured by Fura‐2 fluorescence in response to exogenously added ATP. The cellular response to ATP, referred to as the calcium signal, is characterized by a brief increase and subsequent decrease in cytosolic Ca 2+ levels. Ultraviolet B irradiation (1.8–9 mJ/cm 2 ) was found to reduce the magnitude of the Ca 2+ signal in a dose‐dependent manner. A 5 min UVB exposure (9 mJ/cm 2 ) completely altered the biphasic nature of the calcium signal, causing only an immediate and steady rise in cytosol Ca 2+ levels. Lower fluences of UVB irradiation (2 min exposure times or 3.6 mJ/cm 2 ) induced a 50% reduction in the calcium signal. When irradiated cells were returned to culture for 3 h after irradiation, calcium signals induced by ATP were normal. In view of the photooxidative nature of UVB irradiation, the oxidative state of cells was assessed by measuring glutathione (GSH) levels. Ultraviolet B irradiation caused a rapid 20% decline in GSH levels that returned to near‐control values after a 3 h postirradiation incubation. The results of this study indicate that fluences lower than previously found to be cataractogenic can perturb calcium cell signaling in cultured lens epithelial cells.
Chemical Characterization, Free Radical Scavenging, and Cellular Antioxidant and Anti‐Inflammatory Properties of a Stilbenoid‐Rich Root Extract of Vitis vinifera (2015)

Dietary stilbenoids are receiving increasing attention due to their potential health benefits. However, most studies concerning the bioactivity of stilbenoids were conducted with pure compounds, for example, resveratrol. The aim of this study was to characterize a complex root extract of Vitis vinifera in terms of its free radical scavenging and cellular antioxidant and anti-inflammatory properties. HPLC-ESI-MS/MS analyses of the root extract of Vitis vinifera identified seven stilbenoids including two monomeric (resveratrol and piceatannol), two dimeric (trans-ɛ-viniferin and ampelopsin A), one trimeric (miyabenol C), and two tetrameric (r-2-viniferin = vitisin A and r-viniferin = vitisin B) compounds which may mediate its biological activity. Electron spin resonance and spin trapping experiments indicate that the root extract scavenged 2,2-diphenyl-1-picrylhydrazyl, hydroxyl, galvinoxyl, and superoxide free radicals. On a cellular level it was observed that the root extract of Vitis vinifera protects against hydrogen peroxide-induced DNA damage and induces Nrf2 and its target genes heme oxygenase-1 and γ-glutamylcysteine synthetase. Furthermore, the root extract could induce the antiatherogenic hepatic enzyme paraoxonase 1 and downregulate proinflammatory gene expression (interleukin 1β, inducible nitric oxide synthase) in macrophages. Collectively our data suggest that the root extract of Vitis vinifera exhibits free radical scavenging as well as cellular antioxidant and anti-inflammatory properties.
Separating Probability Elicitation From Utilities (1988)

Abstract This article deals with the separation of probability elicitation from utilities. We show that elicited probabilities can be related to utilities not just through the explicit or implicit payoffs related to the elicitation process, but also through other stakes the expert may have in the events of interest. We study three elicitation procedures—lotteries, scoring rules, and promissory notes—and show how the expert's utility function and stakes in the events can influence the resulting probabilities. Particularly extreme results are obtained in an example involving a market at equilibrium. The applicability of a no-stakes condition and some implications for probability elicitation are discussed. Let π represent an expert's probability for an event A, and let p denote the elicited probability from some elicitation procedure. We determine the value of p that maximizes the expert's expected utility. When utility is linear in money, p = π for all of the procedures studied here. Under nonlinear utility, the lottery procedure still yields p = π as long as the expert has no other stakes involving the occurrence or nonoccurrence of A (the no-stakes condition). With the scoring-rule and promissory-note procedures, the no-stakes condition is no longer sufficient for p = π in the presence of nonlinear utility. If the no-stakes condition holds and the elicitation-related payoffs approach 0, then p = π in the limit. For all three procedures, the combination of nonlinear utility and other stakes can lead to values of p other than π. Furthermore, an analysis of the promissory-note procedure in a market setting gives a very extreme result: In a complete market at equilibrium for such promissory notes, the elicited probability depends on the market price, not on π. Is the no-stakes condition reasonable? We suggest that it often is not, since experts are likely to have significant stakes already, particularly in important situations. Moreover, it may be difficult to determine exactly what those stakes are (and perhaps to obtain accurate information about the expert's utility function). This creates somewhat of a dilemma for probability elicitation, implying that, at least in theory, it is difficult to separate probability elicitation from utilities.
From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction (2018)

Drug addiction is a complex disorder driven by dysregulation in molecular signaling across several different brain regions. Limited therapeutic options currently exist for treating drug addiction and related psychiatric disorders in clinical populations, largely due to our incomplete understanding of the molecular pathways that influence addiction pathology. Recent work provides strong evidence that addiction-related behaviors emerge from the convergence of many subtle changes in molecular signaling networks that include neuropeptides (neuropeptidome), protein-protein interactions (interactome) and post-translational modifications such as protein phosphorylation (phosphoproteome). Advancements in mass spectrometry methodology are well positioned to identify these novel molecular underpinnings of addiction and further translate these findings into druggable targets for therapeutic development. In this review, we provide a general perspective of the utility of novel mass spectrometry-based approaches for addressing critical questions in addiction neuroscience, highlighting recent innovative studies that exemplify how functional assessments of the neuroproteome can provide insight into the mechanisms of drug addiction.
Formalization of discrete processes of forming porous materials using information models (2017)

The author has developed an information model of the material based on the analysis of their corresponding textures. The model represents the attribute information on the system state in discrete time of formation of the structure of the material. The model allows us to create an information replica of the media (texture) on the state of the system at a specific point in time and multiply it in the form of information copies of the system state on objects created in other places, in other conditions and at other time periods.
Constraining the Evolution of ZZ Ceti (2003)

Abstract We report our analysis of the stability of pulsation periods in the DAV star (pulsating hydrogen atmosphere white dwarf) ZZ Ceti, also called R548. Based on observations that span 31 years, we conclude that the period 213.132605 s observed in ZZ Ceti drifts at a rate dP/dt≤(5.5±1.9)×10 Constraining the cooling rate of ZZ Ceti aids theoretical evolutionary models and white dwarf cosmochronology. The drift rate of this clock is small enough that reflex motion caused by any orbital planets is detectable within limits; our Ṗ constraint places limits on the mass and/or distance of any orbital companions.
Weight changes after hospitalization for worsening heart failure and subsequent re-hospitalization and mortality in the EVEREST trial (2009)

Increases in BW after hospitalization for worsening HF was predictive of repeat hospitalization events, but not mortality in the post-discharge period.
Preparation of a MoS2/carbon nanotube composite as an electrode material for high-performance supercapacitors (2018)

MoS<sub>2</sub> and MoS<sub>2</sub>/carbon allotrope (MoS<sub>2</sub>/C) composites for use as anodes in supercapacitors were prepared <i>via</i> a facile hydrothermal method. In this study, we report the effects of various carbon-based materials (2D graphene nanosheet (GNS), 1D carbon nanotube (CNT), and 0D nano carbon (NC)) on the electrochemical performances. Among all nanocomposites studied, MoS<sub>2</sub>/CNT exhibited the best electrochemical performance. Specifically, the MoS<sub>2</sub>/CNT composite exhibits remarkable performances with a high specific capacitance of 402 F g<sup>-1</sup> at a current density of 1 A g<sup>-1</sup> and an outstanding cycling stability with 81.9% capacitance retention after 10 000 continuous charge-discharge cycles at a high current density of 1 A g<sup>-1</sup>, making it adaptive for high-performance supercapacitors. The superiority of MoS<sub>2</sub>/CNT was investigated by field emission scanning electron microscopy and transmission electron microscopy, which showed that MoS<sub>2</sub> nanosheets were uniformly loaded into the three-dimensional interconnected network of nanotubes, providing an excellent three dimensional charge transfer network and electrolyte diffusion channels while effectively buffering the collapse and aggregation of active materials during charge-discharge processes. Overall, the MoS<sub>2</sub>/CNT nanocomposite synthesized by a simple hydrothermal process presents a new and promising candidate for high-performance anodes for supercapacitors.
Supplement for "Change Detection from Temporal Sequences of Class Labels: Application to Land Cover Change Mapping" (2013)

This is a supplement for paper titled "Change Detection from Temporal Sequences of Class Labels: Application to Land Cover Change Mapping" which is included in proceedings of SIAM International Conference of Data Mining, 2013.\nThis supplement section has enlarged figures mentioned in the main paper and additional experiments on synthetic data.
A General Uncatalyzed Method for the Synthesis ofO-Silylated Oximes (2003)

Abstract Aldoximes and ketoximes were smoothly and efficiently O-silylated at room temperature with diverse chlorosilanes such as TMSCl, TBSCl, or TIPSCl in dichloromethane or THF, using imidazole as a base to trap the generated hydrochloric acid.
Adolescent psychological and social predictors of young adult smoking acquisition and cessation: A 10-year longitudinal study. (2011)

First evidence that parent noncompliance, friend compliance, and a lack of achievement motivation predict smoking acquisition and (with the exception of parent noncompliance) smoking continuation in young adulthood. Including these psychological factors in future interventions designed to promote young adult smoking cessation may be useful.
Synthesis of the A14-21 sequence of ovine insulin by the solid-phase technique (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of the A14-21 sequence of ovine insulin by the solid-phase techniqueErik Th. M. Wolters, Godefridus I. Tesser, and Rutger J. F. NivardCite this: J. Org. Chem. 1974, 39, 23, 3388–3392Publication Date (Print):November 1, 1974Publication History Published online1 May 2002Published inissue 1 November 1974https://pubs.acs.org/doi/10.1021/jo00937a018https://doi.org/10.1021/jo00937a018research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Automated flaw detection scheme for cast austenitic stainless stell weld specimens using Hilbert-Huang transform of ultrasonic phased array data (2012)

The objective of this work is to develop processing algorithms to detect and localize flaws using ultrasonic phased-array data. Data was collected on cast austenitic stainless stell (CASS) weld specimens onloan from the U.S. nuclear power industry' Pressurized Walter Reactor Owners Group (PWROG) traveling specimen set. Each specimen consists of a centrifugally cast stainless stell (CCSS) pipe section welded to a statically cst(SCSS) or wrought (WRSS) section. The paper presents a novel automated flaw detection and localization scheme using low frequency ultrasonic phased array inspection singals from the weld and heat affected zone of the based materials. The major steps of the overall scheme are preprocessing and region of interest (ROI) detection followed by the Hilbert-Huang transform (HHT) of A-scans in the detected ROIs. HHT offers time-frequency-energy distribution for each ROI. The Accumulation of energy in a particular frequency band is used as a classification feature for the particular ROI.
Patient Information: To Share or Not to Share? (2018)

This commentary considers the General Medical Council's new guidance, Confidentiality: Good Practice in Handling Patient Information, which came into effect in April 2017. The commentary highlights some of the changes from the previous guidance and argues that, while some areas could have been developed further, the new guidelines are in general more detailed and user-friendly than previously, and will therefore be of benefit to practitioners. The commentary also highlights further developments on the horizon, such as new data protection legislation.
Heat Transfer in Dropwise Condensation of Steam (1972)

水蒸気の滴状凝縮時における壁表面温度の測定法を種々検討し, 精度ある測定法を確立した。本法により垂直銅板上における表面温度の変動が約1℃に達することおよびその変動の様子が写真撮影による液滴の挙動と実によく対応することがわかった。次に表面温度変動の実測値を用いて凝縮熱量の時間的変化を計算した, それによれば落下滴の掃除作用によって生起されるいわゆる裸の面が大きく伝熱に寄与することが推論される。
LTS using decision forest of regression trees and neural networks (2008)

Letter-to-sound (LTS) rules play a vital role in building a speech synthesis system.In this paper, we apply various Machine Learning approaches like Classification and Regression Trees (CART), Decision Forest, forest of Artificial Neural Network (ANN) and Auto Associative Neural Networks (AANN) for LTS rules.We used these techniques mainly for Schwa deletion in Hindi.We empirically show that the LTS using Decision Forest and Forest of ANNs outperforms the previous CART and normal ANN approaches respectively, and the non discriminative learning technique of AANN could not capture the LTS rules as efficiently as discriminative techniques.We explore use of syllabic features, namely, syllabic structure, onset of the syllable, number of syllables and place of Schwa along with primary contextual features.The results showed that use of these features leads to good performance.The Decision Forest and forest of ANNs approaches yielded phone accuracy of 92.86% and 93.18% respectively using the newly incorporated features for Hindi LTS.
A Fabry–Perot interferometer for micrometer-sized cantilevers (2005)

We have developed a Fabry–Perot interferometer detecting the deflection of micrometer-sized cantilevers and other micromechanical devices, at a working distance of 0.8mm. At 1MHz, a noise floor of 1fm∕Hz is obtained. The detector is mounted on a piezo motor for three-axis alignment. The angular alignment is not critical. The interferometer can be operated in vacuum, air, and liquid. It is particularly suited for scanning force microscopy with small cantilevers, or with larger cantilevers simultaneously monitoring vertical and lateral forces.
Love, Cajun Style (review) (2006)

Reviewed by: Strong at the Heart: How It Feels to Heal from Sexual Abuse April Spisak Lehman, Carolyn Strong at the Heart: How It Feels to Heal from Sexual Abuse. Kroupa/Farrar, 2005 [176p] illus. with photographs ISBN 0-374-37282-9$17.00 Reviewed from galleys R Gr. 8-12 Love is in the sultry summer air in Sweetbay, Louisiana—maybe a little too much so for Lucy's taste. It's one thing to talk philosophically about love with her friends Mary Jordan and Evie, but another thing altogether when it comes close enough to touch. When Lucy finds out that her mom is posing for Victor, a widowed artist who has just moved to town, as well as giving him cooking lessons, she worries that something more than étouffée is on the menu. Worse, when a handsome teacher, also new to town, kisses Lucy on the darkened stage of the school auditorium, she is confused by sensations that she knows are just wrong. On the other hand, she is just as confused by the sensations she feels with Dewey, Victor's son, which she knows are just right. Fortunately, the people of Sweetbay have been at this love and life business too long to be thrown by any of it, and Lucy finds that things gently right themselves if people are brave enough to ask for what they want. Les Becquets cooks up a pot of small-town southern life that comes together like a jambalaya—spiced with humor and goodwill, with tasty chunks of occasional conflict and misunderstanding that melt away into a harmonious happy ending. Her secondary characters add colorful energy to the plot, each bringing his or her own hard-won wisdom on the complications of love to the table. The text is permeated by a general sense of warmth and well-being as it explores relationships that haven't always gone smoothly, but endure and grow nonetheless. The result is a piquant dish with a warm, feel-good finish—fans of Ann Brashares and Meg Cabot will definitely want a taste of this one. Copyright © 2006 The Board of Trustees of the University of Illinois
The role of H-bonds in the solid state organization of [1]benzothieno[3,2-b][1]benzothiophene (BTBT) structures: bis(hydroxy-hexyl)-BTBT, as a functional derivative offering efficient air stable organic field effect transistors (OFETs) (2016)

The rapid and inexpensive functionalization of the BTBT core with hydroxyl end group functionalized hexyl chains offered a new platform for functionalized self-organising BTBT.
ChemInform Abstract: SUBSTRATE‐REAGENT COMPLEXATION ABILITY IN ENANTIOSELECTIVE 1,4‐ADDITION REACTIONS (1982)

Abstract Die beiden Prolinol‐Derivate (I) werden zusammen mit Methylmagnesiumhalogeniden und Cu‐Halogeniden zu 1,4‐Additionsreaktionen an die aJS‐ungesättigten Ketone(II) ‐(III) eingesetzt.
CNS Effects of CB2 Cannabinoid Receptors (2009)

Cannabinoids, endocannabinoids and marijuana use activates two well characterized cannabinoid receptors (CBRs), CB1-Rs and CB2-Rs. The expression of CB1-Rs in the brain and periphery has been well studied, but CB2-Rs have received much less attention than CB1-Rs. CB2-Rs were previously thought to be predominantly expressed in immune cells in the periphery and were traditionally referred to as peripheral CB-Rs. We and others have now demonstrated the presence of CB2-Rs in neuronal, glial and endothelial cells in the brain, and this warrants a re-evaluation of the central nervous system (CNS) effects of CB2-Rs. However, many features of CB2-R gene structure, variants and regulation remain poorly characterized compared to the CB1-R. To further improve understanding of the role of CB2-Rs in the brain, we hypothesized that genetic variants of CB2-R (CNR2) gene might be associated with depression in a human population and that alteration in CNR2 gene expression may be involved in the effects of abused substances in rodents. In this review we show that our data and those of others reveal that CB2-Rs are expressed in neurons in the brain and play a role in depression and substance abuse beyond neuro-immuno-cannabinoid activity.