Ulceration of the Tongue: A Complication of Captopril Therapy (1981)

Brief Reports1 May 1981Ulceration of the Tongue: A Complication of Captopril TherapyM. GARY NICHOLLS, M.D., ANDREW H. MASLOWSKI, M.D., HAMID IKRAM, M.D., ERIC A. ESPINER, M.D.M. GARY NICHOLLS, M.D., ANDREW H. MASLOWSKI, M.D., HAMID IKRAM, M.D., ERIC A. ESPINER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-5-659 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe oral converting enzyme inhibitor, captopril, is a major advance in the treatment of some patients with severe hypertension or resistant congestive heart failure. We have been impressed with its efficacy in seven patients with heart failure. However, we encountered the development of painful tongue ulcers in one patient who earlier noted a profound diminution in taste sensation during treatment with captopril. Tongue ulceration previously has not been observed during captopril therapy.The patient, a 72-year-old retired carpenter, presented in 1979 with congestive heart failure resistant to conventional treatment with digoxin, furosemide (up to 2000 mg/d) and vasodilators (prazosin hydrochloride...References1. MCNEILANDERSONCHRISTOPHIDISJARROTTLOUIS JANBW. Taste loss associated with oral captopril treatment. Br Med J. 1979;2:1555-6. CrossrefMedlineGoogle Scholar2. SEEDAT Y. Aphthous ulcers of mouth from captopril. Lancet. 1979;2:1297-8. Letter. CrossrefMedlineGoogle Scholar3. KRIPALANIMCKINSTRYSINGHVIWILLARDVUKOVICHMIGDALOF KDSDRB. Disposition of Captopril in normal subjects. Clin Pharmacol Therap. 1980;27:636-41. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. GARY NICHOLLS, M.D.; ANDREW H. MASLOWSKI, M.D.; HAMID IKRAM, M.D.; ERIC A. ESPINER, M.D.Affiliations: Cardiology and Endocrinology Departments The Princess Margaret Hospital Christchurch New Zealand PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdverse drug reactions in the oral cavityCardiovascular drugs-induced oral toxicities: A murky area to be revisited and illuminatedA dverse D rug R eactions in the O rofacial R egionO ral A dverse D rug R eactions to C ardiovascular D rugsOral drug reactionsNicorandil can induce severe oral ulcerationRole of drug exposure in aphthous ulcers: a case–control studyAngioedema associated with angiotensin-converting enzyme inhibitorsOropharyngeal Angioedema Associated with the Use of Angiotensin‐Converting Enzyme InhibitorsAngiotensin-converting enzyme inhibitors implicated in oral mucosal lichenoid reactionsAngiotensin converting enzyme inhibitors. Properties and side effects.Oral Drug ReactionsAngiotensin inhibitors and other vasodilators with special reference to congestive heart failureUne complication rare du captopril: l'ulcération des muqueuses linguales et jugalesAntihypertensive drugsLong-Term Treatment of Childhood Hypertension with CaptoprilHemodynamic and hormonal responses during captopril therapy for heart failure: Acute, chronic and withdrawal studiesCaptopril: Clinical Pharmacology and Benefit-to-Risk Ratio in Hypertension and Congestive Heart FailureInhibitors of the Renin-Angiotensin System as Antihypertensive Agents 1 May 1981Volume 94, Issue 5Page: 659-659KeywordsEnzyme inhibitorsHeart failureHypertensionPatientsPhotographyResistant hypertensionTasteTongueUlcersVasodilators ePublished: 1 December 2008 Issue Published: 1 May 1981 Copyright & Permissions© 1981 American College of PhysiciansPDF downloadLoading ...