gebhart/patrepeval huggingface dataset:
Reaping the Benefit of Temporal Silence to Improve Communication Performance (2005)

Communication misses - those serviced by dirty data in remote caches - are a pressing performance limiter in shared-memory multiprocessors. Recent research has indicated that temporally silent stores can be exploited to substantially reduce such misses, either with coherence protocol enhancements (MESTI); by employing speculation to create atomic silent store-pairs that achieve speculative lock elision (SLE); or by employing load value prediction (LVP). We evaluate all three approaches utilizing full-system, execution-driven simulation, with scientific and commercial workloads, to measure performance. Our studies indicate that accurate detection of elision idioms for SLE is vitally important for delivering robust performance and appears difficult for existing commercial codes. Furthermore, common datapath issues in out-of-order cores cause barriers to speculation and therefore may cause SLE failures unless SLE-specific speculation mechanisms are added to the microarchitecture. We also propose novel prediction and silence detection mechanisms that enable the MESTI protocol to deliver robust performance for all workloads. Finally, we conduct a detailed execution-driven performance evaluation of load value prediction (LVP), another simple method for capturing the benefit of temporally silent stores. We show that while theoretically LVP can capture the greatest fraction of communication misses among all approaches, it is usually not the most effective at delivering performance. This occurs because attempting to hide latency by speculating at the consumer, i.e. predicting load values, is fundamentally less effective than eliminating the latency at the source, by removing the invalidation effect of stores. Applying each method, we observe performance changes in application benchmarks ranging from 1% to 14% for an enhanced version of MESTI, -1.0% to 9% for LVP, -3% to 9% for enhanced SLE, and 2% to 21% for combined techniques
Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7 (2010)

Epidermal growth factor-like domain 7 (Egfl7) is important for regulating tubulogenesis in zebrafish, but its role in mammals remains unresolved. We show here that endothelial overexpression of Egfl7 in transgenic mice leads to partial lethality, hemorrhaging, and altered cardiac morphogenesis. These defects are accompanied by abnormal vascular patterning and remodeling in both the embryonic and postnatal vasculature. Egfl7 overexpression in the neonatal retina results in a hyperangiogenic response, and EGFL7 knockdown in human primary endothelial cells suppresses endothelial cell proliferation, sprouting, and migration. These phenotypes are reminiscent of Notch inhibition. In addition, our results show that EGFL7 and endothelial-specific NOTCH physically interact in vivo and strongly suggest that Egfl7 antagonizes Notch in both the postnatal retina and in primary endothelial cells. Specifically, Egfl7 inhibits Notch reporter activity and down-regulates the level of Notch target genes when overexpressed. In conclusion, we have uncovered a critical role for Egfl7 in vascular development and have shown that some of these functions are mediated through modulation of Notch signaling.
Characterization of products from clay catalyzed polymerization of tall oil fatty acids (1974)

Abstract Products obtained by acid clay catalyzed dimerization of oleic, elaidic, and tall oil fatty acids were characterized. The monomeric products (35% of total) consisted of stearic, octadecenoic (66% trans‐ ), and mid chain monomethyl branched acids, both saturated and unsaturated. The polymeric products (65% of total) consisted of linear, alicyclic, aromatic, and polycyclic dimers. The tall oil fatty acid based dimer closely resembled oleic dimer in polycyclic character and linoleic dimer in aromatic and linear structures. Oleic dimers contained the highest linear structural content, while linoleic dimer contained the largest polycyclic content. Alicyclic structures were the principal components of all three products. The monocyclic dimer structures present consisted of six membered ring systems with linoleic and tall oil fatty acid dimers containing the highest aromatic contents.
Temperature dependence of reversible photodarkening in Ga:La:S and Ga:La:S:O glass fibres (2001)

I. Introduction <br/>Glasses based on gallium and lanthanum sulphides have been investigated because of their properties, such as low phonon energy, high rare-earth solubility and high nonlinearity, which make them attractive for the fabrication of active waveguide devices for photonic applications, such as fibre lasers, amplifiers and all-optical switches (1,2). <br/><br/>It is well known that glassy chalcogenides exhibit a number of modifications to their physical properties under the action of light or temperature (3). Reversible photodarkening (PD) is a red-shift of the position of the electronic edge, induced by bandgap or sub-bandgap illumination (4). We have investigated PD in unclad glass fibres with nominal composition 65Ga<sub>2</sub>S<sub>3</sub>:32La<sub>2</sub>S<sub>3</sub>:3La<sub>2</sub>O<sub>3</sub> (Ga:La:S) and 72.5Ga<sub>2</sub>S<sub>3</sub>:27.5La<sub>2</sub>O<sub>3</sub> (Ga:La:S:O) respectively. Both fundamental and practical reasons justify the interest in the PD effect in these materials. From a fundamental point of view, one is interested in understanding the phenomena underlying the absorption edge in these amorphous semiconducting materials. A more practical aspect is that PD also affects their transparency in the near IR region, which is relevant to most photonic applications. Here we report for the first time the existence of PD effect in these oxysulphide glasses and we present a description of its dependence on temperature, in the range 77-563 K.
Ultrasoft Liquid Metal Elastomer Foams with Positive and Negative Piezopermittivity for Tactile Sensing (2020)

Abstract Soft, capacitive tactile (pressure) sensors are important for applications including human–machine interfaces, soft robots, and electronic skins. Such capacitors consist of two electrodes separated by a soft dielectric. Pressing the capacitor brings the electrodes closer together and thereby increases capacitance. Thus, sensitivity to a given force is maximized by using dielectric materials that are soft and have a high dielectric constant, yet such properties are often in conflict with each other. Here, a liquid metal elastomer foam (LMEF) is introduced that is extremely soft (elastic modulus 7.8 kPa), highly compressible (70% strain), and has a high permittivity. Compressing the LMEF displaces the air in the foam structure, increasing the permittivity over a large range (5.6–11.7). This is called “positive piezopermittivity.” Interestingly, it is discovered that the permittivity of such materials decreases (“negative piezopermittivity”) when compressed to large strain due to the geometric deformation of the liquid metal droplets. This mechanism is theoretically confirmed via electromagnetic theory, and finite element simulation. Using these materials, a soft tactile sensor with high sensitivity, high initial capacitance, and large capacitance change is demonstrated. In addition, a tactile sensor powered wirelessly (from 3 m away) with high power conversion efficiency (84%) is demonstrated.
Low-Temperature Low-Resistivity PEALD TiN Using TDMAT under Hydrogen Reducing Ambient (2008)

Titanium nitride (TiN) films were deposited using plasma-enhanced atomic layer deposition (PEALD) from the organometallic precursor tetrakis-dimethyl-amino-titanium (TDMAT) with hydrogen () as a coreactant. Low-resistivity values lying from 210 to were achieved for 10 nm thick films deposited at low temperature: . The effects of temperature, plasma time, and plasma power were investigated. It was demonstrated that the chemical reaction is complementary and self-limiting. A minimum energy is necessary to reach the low-resistivity plateau. Chemical and physical properties of the films are also reported and a surface reaction mechanism is proposed. It is suggested that after TDMAT chemisorption to the surface, amines are removed by hydrogen radicals, and at the same time, titanium carbide bonds (Ti–C) are formed. The low resistivity results from the presence of or phases in the PEALD TiN film. The industrial viability of this process was also evaluated on 300 mm wafers. Good performances were obtained on wafer-to-wafer uniformity and step coverage, while some improvements related to the within-wafer uniformity are required.
Using Clothoidal Spirals to Generate Smooth Tool Paths for High Speed Machining (2004)

We present a new and innovative method to generate Contour Parallel tool paths using Clothoidal spirals for 2.5D pocket milling. The tool paths generated by the proposed method are more suitable for High Speed Machining compared to the traditional tool paths. Mechanical parts, such as those in Aerospace industry, Mold and Dies industry, etc require large volumes of milling operations. Modern High Speed CNC Machines are used in making of these parts. Although the High Speed CNC machines can provide very high spindle speed, due to various reasons, it has not been possible to use their High speed capabilities to their full extent. Two of the main reasons being, complex pocket geometry and complex tool path geometry. Most pockets are made up of sharp corners. In the traditional contour parallel pocket milling tool paths, as the cutting tool approaches these corners, they have to undergo a sudden change in directions and the acceleration of the tool has to be instantaneously decreased. Also, there is an instantaneous increase in the chip volume and the resultant forces acting on the cutting tool. In our proposed method we smooth these sharp corners of the traditional tool path by using Clothoidal spirals. The Clothoidal curves which have traditionally been used for Highways and Rail track design, have an unique property, according to which, the curvature of the Clothoidal spirals varies linearly with the length of the curve. By using these curves of uniformly varying curvature, we reduce the magnitude of the sudden direction changes that the cutting tool has to undergo at the sharp pocket corners. The cutting tool is subjected to lesser resultant forces and has a comparatively uniform acceleration. Machining time is also expected to be reduced by our proposed method.
Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells (2008)

Although the spatial and temporal orchestration of early vertebrate embryogenesis is missing from cell culture systems, recent work suggests that many of the same signals affecting neural induction in vertebrate embryos also regulate embryonic stem (ES) cell neurogenesis. One key regulatory mechanism involved in both in vivo and in vitro neural induction is the inhibition of bone morphogenetic protein (BMP) signals. Wnts and Fibroblast Growth Factors represent additional regulatory influences, which may affect the adoption of neural fates through both BMP-dependent and BMP-independent mechanisms. Insights into neural induction in vivo help to guide paradigms for promoting neural differentiation by ES cells. Conversely, insights into the mechanisms by which ES cells adopt neural fates may provide an improved understanding of neural induction in the early embryo.
Chemopreventive activity of a C-glucuronide analog of N-(4-hydroxyphenyl) retinamide-O-glucuronide against mammary tumor development and growth. (1999)

The long term chemopreventive effects of the N-(4-hydroxyphenyl) retinamide-O-glucuronide (4-HPROG), and its stable C-linked benzyl glucuronide analog, retinamidobenzyl glucuronide (4-HPRCG) on the growth and development of 7,12-dimethylbenz[a]anthracene-induced mammary tumors were compared. The retinamidobenzyl glucuronide is stable toward acid hydrolysis and resists the actions of beta-glucuronidase. The results indicate that the C-linked glucuronide analog, 4-HPRCG has a greater chemopreventive potency than an equimolar concentration of 4-HPROG. Tumor latency was 15% longer in rats fed 2 mmol/kg diet of 4-HPRCG as compared to 4-HPROG. At 80 days post DMBA-intubation, tumor incidence was 57% and 27% in the 4-HPROG and 4-HPRCG treated rats, respectively. Tumor multiplicity was also markedly decreased in the 4-HPRCG treated rats. At 80 days post DMBA intubation the control rats had an average of 1.43 tumors/rat compared to 0.71 and 0.36 tumors/rat in the 4-HPROG and 4-HPRCG respectively. The higher potency and low toxicity of 4-HPRCG suggest that this stable analog may have an in vivo chemopreventive advantage over its analog, 4-HPROG. The results also demonstrated that these glucuronide analogs do not bind effectively in vitro either to the nuclear retinoid receptors or to the cellular retinoid binding proteins. Regardless of the mode of action of these retinoids, they are clearly effective chemopreventive agents.
High-efficiency orange and yellow organic light-emitting devices using platinum(<scp>II</scp>) complexes containing extended π-conjugated cyclometalated ligands as dopant materials (2007)

Two luminescent platinum(II) complexes 1 and 2 containing extended π-conjugated cyclometalated ligands have been used as dopant materials for the construction of two high-efficiency organic light-emitting devices I and II. Device I (containing dopant 1) emits orange emission and exhibits a maximum external quantum efficiency of 12.4%, a maximum luminous efficiency of 32.3cd∕A, and a maximum power efficiency of 11.2lm∕W. Device II (containing dopant 2) emits yellow light and exhibits a maximum external quantum efficiency of 16.1%, a maximum luminous efficiency of 51.8cd∕A, and a maximum power efficiency of 23.2lm∕W.
Expression of α‐smooth muscle actin in canine intervertebal disc cells <i>in situ</i> and in collagen‐glycosaminoglycan matrices <i>in vitro</i> (1999)

The objective of this study was to investigate the presence of a contractile actin isoform, alpha-smooth muscle actin, in annulus fibrosus cells in situ and in two and three-dimensional cultures. Annulus fibrosus cells were isolated from healthy adult dogs, serial passaged, and then injected into porous collagen-glycosaminoglycan copolymers consisting of either type-I or type-II collagen. Alpha-smooth muscle actin was detected in the cells in tissue samples and in culture by immunohistochemistry. The number of cells and glycosaminoglycan content of the matrices were determined after 1, 7, and 14 days, and the diameters of the specimens were measured every 2 days. Although few annulus fibrosus cells in vivo displayed the presence of the alpha-smooth muscle actin isoform, most cells in two-dimensional culture demonstrated this phenotype. The contractile behavior of these cells was shown by the cell-mediated contraction of type-I collagen-glycosaminoglycan scaffolds after 8 days in culture. Glycosaminoglycan production was not significantly different in the seeded type-I matrices than in the unseeded matrices, whereas the seeded type-II matrices had a significant increase in glycosaminoglycan production between days 1 and 14 compared with the unseeded controls. This is the first report of both the expression of the contractile alpha-smooth muscle actin isoform in intervertebral disc cells and the ability of the cells to contract a collagen matrix. This finding could aid in better understanding the nature of cells in the annulus.
Docosahexaenoic Acid and Arachidonic Acid Prevent Essential Fatty Acid Deficiency and Hepatic Steatosis (2011)

Supplementation of sufficient amounts of docosahexaenoic and arachidonic acids alone without α-linolenic and linoleic acids meets essential fatty acid requirements and prevents hepatic steatosis in a murine model.
A 143MHz 1.1W 4.5Mb dynamic TCAM with hierarchical searching and shift redundancy architecture (2004)

A 4.5 Mb dynamic ternary CAM (DTCAM) is designed in 0.13 /spl mu/m embedded DRAM technology. A performance of 143 M searches/sec is achieved at a power dissipation of 1.1 W and on a small silicon area of 32 mm/sup 2/. A 3.6-times yield improvement is estimated by employing pipelined hierarchical searching and row/column-shift redundancy.
특집 : 한국 농촌의 미래 ; 환경축제의 실태와 가능성: 함평나비축제를 중심으로 (2003)

전국의 지역축제는 지역문화 증진과 지역 활성화를 넘어서 `지역 재구성`의 의미도 내포하고 있다. 일년에 400여개의 축제가 개최되고 매년 사라지는 축제가 있는가 하면 새로 생기는 축제도 있다. 지방정부는 축제를 만들어내고 개최하려고 하는가. 대부분의 축제는 지방정부에 의해서 추진되고 있고, 지방선거를 포함한 지역 권력구조는 축제의 성격을 규정하기도 한다. 특히 지방자치 단체장의 시간적 제한성과 선거는 지역축제를 방문자의 많고 적음에 묶어버렸다. 그 결과 지역축제가 지역사회 재구성에 미치는 다양한 역할에 대한 고민은 뒷전으로 밀려나나고 방문객 수를 고려하는 축제로 변화되고 있다. 그리고 지방정부는 앞 다투어 지역 대표축제를 만들려고 고민하고 있다. 지역축제에 관심을 가졌던 것은 축제가 지역사회개발, 지역사회의 재구성에 큰 영향을 미치고 있다고 생각했기 때문이었다. 이 글은 함평 나비축제를 중심으로 지역의 대표축제가 어떻게 만들어지는지 살펴보고, 지역사회에 미치는 영향에 대해서도 살펴보고자 하였다. 함평의 나비축제를 사례로 했던 것은 짧은 기간에 가장 성공한 축제로 평가받고 있고, 둘째는 축제의 자원을 나비라는 곤충으로 정했다는 점이다. 그리고 관광 불모지인 함평을 친환경농업지역과 생태환경보전지역으로 이미지화하여 지역경제를 활성화한다는 목표를 가지고 있다는 점이다. 지역축제가 대규모화되면서 수용능력과 준비과정에 어려움이 노출되고 있다. 공무원과 주민의 동원이 자발성을 넘어서 강요되기까지 하고 있다. 그 결과 주민참여가 주민동원으로 변질될 우려가 나타나고 있다. 나비축제와 같이 인근 지역 특히 영산강을 기반으로 만들어진 동일한 삶의 공간, 혹은 광역자치단체와 연계하여 운영하는 방안과 갈이 새로운 축제운영방안이 모색되어야 한다. 여기에 백화점식으로 프로그램을 부과하는 것은 주제의 선명성만 훼손할 우려가 있다. 더욱 중요한 것은 지역축제가 지역주민의 삶과 어떻게 연결되는가 하는 점이다. 지금까지 대부분의 지역축제는 지방정부가 기획하지만 그 결과는 주민들에게 돌아오기 때문에 시민사회 영역에서 축제에 대한 적극적인 개입과 평가가 이루어져야 한다. 나비축제가 주민의 삶의 질을 높이는 방향으로 나가기 위해서는 주민 스스로 이미 만들어진 친환경 이미지에 맞는 서비스를 제공해야 한다. 그리고 지방정부도 이제 더 이상 이벤트적 전시적 축제는 멈추고 기존의 축제에 대한 깊은 성찰이 필요하며 축제의 지역주의를 넘어서 생활영역 단위로 축제로 재편성되어야 한다. 이러한 현상을 살펴볼 때 지역축제에 대한 관심은 지역의 다양한 정치 사회적 관계를 이해하는 좋은 계기가 될 수 있다.
The clinical benefit of pegylated liposomal doxorubicin in patients with metastatic breast cancer previously treated with conventional anthracyclines: a multicentre phase II trial (2006)

This study evaluates the clinical benefit of pegylated liposomal doxorubicin (PLD) in patients with metastatic breast cancer (MBC), previously treated with conventional anthracyclines. Seventy-nine women with MBC previously treated with anthracyclines received PLD 50 mg m(-2) every 4 weeks. All patients were previously treated with chemotherapy and 30% of patients had > or =3 prior chemotherapies for metastatic disease. Patients were considered anthracycline resistant when they had disease progression on anthracycline therapy for MBC or within 6 months of adjuvant therapy. The overall clinical benefit rate (objective response+stable disease > or =24 weeks) was 24% (16.1% in patients with documented anthracycline resistance vs 29% in patients classified as having non-anthracycline-resistant disease). There was no difference with respect to the clinical benefit between patients who received PLD >12 months and those who received PLD < or =12 months since last anthracycline treatment for metastatic disease (clinical benefit 25 vs 24.1%, respectively). Median time to progression and overall survival were 3.6 and 12.3 months, respectively. The median duration of response was 12 months, and the median time to progression in patients with stable disease (any) was 9.5 months. Fourteen patients (17.7%) had a prolonged clinical benefit lasting > or =12 months. In conclusion, PLD was associated with an evident clinical benefit in anthracycline-pretreated patients with MBC.
Two-Dimensional Conductometric Detection in Ion Chromatography. Analyte Identification, Quantitation of Very Weak Acid Anions, and Universal Calibration (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-Dimensional Conductometric Detection in Ion Chromatography. Analyte Identification, Quantitation of Very Weak Acid Anions, and Universal CalibrationAnna. Sjoegren and Purnendu K. DasguptaCite this: Anal. Chem. 1995, 67, 13, 2110–2118Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/ac00109a033https://doi.org/10.1021/ac00109a033research-articleACS PublicationsRequest reuse permissionsArticle Views134Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Benefits and challenges of managing heterogeneous data centers (2013)

Today's businesses have a wealth of options available to them for running their applications. They can use proprietary infrastructures, private data centers, co-location facilities, or public clouds. Applications can be deployed on native hardware or virtualization can be used to improve consolidation and manageability. Public cloud platforms are growing in popularity, but businesses must decide both what types of services to use within a cloud and which cloud platform to use in the first place. While making use of these diverse resources poses management challenges, it also opens new opportunities for optimizing performance and ensuring reliability by carefully matching applications to the resources that will best support them. In this paper we present the benefits and drawbacks of data center diversity, and discuss our experience enhancing IBM's Tivoli Endpoint Manager system to better support mixed proprietary infrastructure, public, and private cloud environments.
Identification and Characterization of SNQ2, a New Multidrug ATP Binding Cassette Transporter of the Yeast Plasma Membrane (1995)

The SNQ2 gene of Saccharomyces cerevisiae, which encodes an ATP binding cassette protein responsible for resistance to the mutagen 4-nitroquinoline oxide, is regulated by the DNA-binding proteins PDR1 and PDR3. In a plasma membrane-enriched fraction from a pdr1 mutant, the SNQ2 protein is found in the 160-kDa over-expressed band, together with PDR5. The SNQ2 protein was solubilized with n-dodecyl beta-D-maltoside from the plasma membranes of a PDR5-deleted strain and separated from the PMA1 H(+/-)ATPase by sucrose gradient centrifugation. The enzyme shows a nucleoside triphosphatase activity that differs biochemically from that of PDR5 (Decottignies, A., Kolaczkowski, M., Balzi, E., and Goffeau, A. (1994) J. Biol. Chem. 269, 12797-12803) and is sensitive to vanadate, erythrosine B, and Triton X-100 but not to oligomycin, which inhibits the PDR5 activity only. Disruption of both PDR5 and SNQ2 in a pdr1 mutant decreases the cell growth rate and reveals the presence of at least two other ATP binding cassette proteins in the 160-kDa overexpressed band that have been identified by amino-terminal microsequencing.