gebhart/patrepeval huggingface dataset:
Context-aware application framework based on Open Service Gateway (2002)

In the era of information appliances, we need more context-aware and intelligent computing for the home than before. Today, there are many types of appliances and devices around us, as well as many middleware protocols for managing them. Many previous ubiquitous computing frameworks were based on specific operating systems or middleware protocols for containing and managing context information and registered services. This caused many problems, such as incompatibility, difficulty of reuse and poor usability. In this paper, we propose a new approach for ubiquitous computing based on OSG (Open Services Gateway), which is a residential gateway standard from the OSGi (OSG Initiative). Almost all homes will be equipped with a residential gateway in the near future. Every application and control for home equipment would be accessed through the residential gateway. OSG is the most appropriate place for a context-aware computing framework to reside, because it is the access point for every user to contact or use any application. It can solve the problems of the previously-developed systems.
A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na<sup>+</sup> current (2014)

Selective inhibition of the slowly inactivating or late Na(+) current (INaL) in patients with inherited or acquired arrhythmia syndrome may confer therapeutic benefit by reducing the incidence of triggers for arrhythmia and suppressing one component of arrhythmia-promoting cardiac substrates (e.g. prolonged refractoriness and spatiotemporal dispersion of action potential duration). Recently, a novel compound that preferentially and potently reduces INaL, GS-458967 (IC50 for block of INaL = 130 nM) has been studied. Experimental measurements of the effects of GS-458967 on endogenous INaL in guinea pig ventricular myocytes demonstrate a robust concentration-dependent reduction in action potential duration (APD). Using experimental data to calibrate INaL and the rapidly activating delayed rectifier K(+) current, IKr, in the Faber-Rudy computationally based model of the guinea pig ventricular action potential, we simulated effects of GS-458967 on guinea pig ventricular APD. GS-458967 (0.1 μM) caused a 28.67% block of INaL and 12.57% APD shortening in experiments, while the model predicted 10.06% APD shortening with 29.33% block of INaL. An additional effect of INaL block is to reduce the time during which the membrane potential is in a high resistance state (i.e. the action potential plateau). To test the hypothesis that targeted block of INaL would make ventricular myocytes less susceptible to small electrical perturbations, we used the computational model to test the degree of APD prolongation induced by small electrical perturbations in normal cells and in cells with simulated long QT syndrome. The model predicted a substantial dose-dependent reduction in sensitivity to small electrical perturbations as evidenced by action potential duration at 90% repolarization variability in the presence of GS-458967-induced INaL block. This effect was especially potent in the 'disease setting' of inherited long QT syndrome. Using a combined experimental and theoretical approach, our results suggest that INaL block is a potent therapeutic strategy. This is because reduction of INaL stabilizes the action potential waveform by reducing depolarizing current during the plateau phase of the action potential. This reduces the most vulnerable phase of the action potential with high membrane resistance. In summary, by reducing the sensitivity of the myocardial substrate to small electrical perturbations that promote arrhythmia triggers, agents such as GS-458967 may constitute an effective antiarrhythmic pharmacological strategy.
Robust MMSE Precoding for the MIMO Complex Gaussian Broadcast Channel (2007)

This paper addresses the design of the linear precoders and decoders of the complex Gaussian broadcast channel in which both the base station and the remote station are equipped with arrays of multiple antennas. An imperfect channel knowledge is assumed at the base station and the minimization of the sum of the mean square errors (MMSE) of the system's substreams is chosen as optimization criterion. A stochastic approach is taken to make the design robust against the channel estimation errors. The solution is based on an iterative algorithm whose convergence is guaranteed. Simulations results emphasize the benefit of the proposed design.
Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. (1995)

We find that tamoxifen is a potent activator of estrogen receptor (ER)- mediated induction of promoters regulated by AP-1 sites including the human collagenase gene promoter and constructs in which an AP-1 site is fused to the herpes thymidine kinase promoter. This contrasts with the inability of tamoxifen to activate otherwise identical promoters bearing classical estrogen response elements. Tamoxifen agonism at AP-1 sites is cell type specific, occurring in cell lines of uterine, but not of breast, origin. It thus parallels tamoxifen agonism in vivo. AP-1 proteins such as Jun or Jun/Fos are needed for tamoxifen stimulation, and tamoxifen increases the transcriptional efficiency of these proteins even when they are provided at optimal amounts. The DNA binding domain (DBD) of ER is required for tamoxifen activation at AP-1 sites. In contrast, estrogen activation is partially independent of this domain. This suggests the existence of two pathways of ER action at AP-1: an alpha (DBD-dependent) pathway activated by tamoxifen, and a beta (DBD-independent) pathway activated by estrogen. Fusing VP16 transcriptional activation functions to ER potentiates the beta, but not the alpha, pathway. We discuss models for the two pathways and the possibility that the AP-1 pathway is a major route by which ER affects target tissue growth and differentiation in vivo.
A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice. (1997)

We have identified a novel retinoid, ALRT1550, that potently and selectively activates retinoic acid receptors (RARs). ALRT1550 binds RARs with Kd values of approximately equal to 1-4 nM, and retinoid X receptors with low affinities (Kd approximately equal to 270-556 nM). We studied the effects of ALRT1550 on cellular proliferation in squamous carcinoma cells. ALRT1550 inhibited in vitro proliferation of UMSCC-22B cells in a concentration-dependent manner with an IC50 value of 0.22 +/- 0.1 (SE) nM. 9-cis-Retinoic acid (ALRT1057), a pan agonist retinoid that activates RARs and retinoid X receptors, inhibited proliferation with an IC50 value of 81 +/- 29 nM. In vivo, as tumor xenografts in nude mice, UMSCC-22B formed well-differentiated squamous carcinomas, and oral administration (daily, 5 days/week) of ALRT1550, begun 3 days after implanting tumor cells, inhibited tumor growth by up to 89% in a dose-dependent manner over the range of 3-75 micrograms/kg. ALRT1550 (30 micrograms/kg) also inhibited growth of established tumors by 72 +/- 3% when tumors were allowed to grow to approximately equal to 100 mm3 before dosing began. In comparison, 9-cis retinoic acid at 30 mg/kg inhibited growth of established tumors by 73 +/- 5%. Interestingly, retinoids did not appear to alter tumor morphologies in UMSCC-22B tumors. Notably, ALRT1550 produced a therapeutic index of approximately equal to 17 in this model, indicating a separation between doses that inhibited tumor growth and that induced symptoms of hypervitaminosis A. In summary, ALRT1550 potently inhibits cellular proliferation in vitro and in vivo in this squamous cell carcinoma tumor model. These data support additional study of ALRT1550 for its potential for improving anticancer therapy in human clinical trials.
Hybrid Controllers for Path Planning: A Temporal Logic Approach (2006)

Robot motion planning algorithms have focused on low-level reachability goals taking into account robot kinematics, or on high level task planning while ignoring low-level dynamics. In this paper, we present an integrated approach to the design of closed–loop hybrid controllers that guarantee by construction that the resulting continuous robot trajectories satisfy sophisticated specifications expressed in the so–called Linear Temporal Logic. In addition, our framework ensures that the temporal logic specification is satisfied even in the presence of an adversary that may instantaneously reposition the robot within the environment a finite number of times. This is achieved by obtaining a Büchi automaton realization of the temporal logic specification, which supervises a finite family of continuous feedback controllers, ensuring consistency between the discrete plan and the continuous execution.
Systems programming in Java (1997)

The Java programming language has been widely accepted as a general purpose language for developing portable applications, toolkits, and applets. With so much activity in industry and academia in these user-level areas, is it surprising that Java is also an equally capable systems programming language? This article describes our experiences at JavaSoft with using Java as a systems-level programming language during the development of JavaOS. The author discusses the motivations for using Java and shows code examples to demonstrate various system-level primitives, including an Ethernet device driver.
Storage of optical information in nano-size cavity arrays under the qubit-light interaction (2014)

We propose the model of one-dimensional polaritonic lattice representing the chain of weakly coupled optical nano-cavities, each containing clusters of qubits. We revealed a variety of both localized and spreading dynamical regimes. We suggest a new physical algorithm for the spatially distributed storage of optical information where various localized dynamical states are used.
EFFECT OF OZONE TREATMENT ON EIMERIA COLCHICI OOCYSTS (2002)

The effect of ozone on the inhibition of the sporulation of Eimeria colchici oocysts in vitro was examined. Lower sporulation ratios were found to correspond directly to longer ozone exposure time. In pheasants, Phasianus colchicus, orally inoculated with ozone-treated oocysts, lower mortality and lower oocysts per gram of feces were observed as compared with birds given untreated oocysts. Thus, treatment of E. colchici oocysts with ozone alone was observed to partially inhibit the growth and infectivity of the oocysts.
Silk-Elastinlike Protein Polymer Liquid Chemoembolic for Localized Release of Doxorubicin and Sorafenib (2016)

Locoregional therapies for cancer are minimally invasive procedures in which the treatment is administered directly into cancerous tissue. Transarterial chemoembolization (TACE) is used to treat intermediate stage hepatocellular carcinoma (HCC). TACE uses an embolic material to block blood flow while coadministering a chemotherapeutic to the neoplastic tissue. Liquid embolics capable of drug loading are at the forefront of development as they allow for deeper permeation of tumor vasculature, increase neoplasm exposure to therapeutics, and resist revascularization by occupying both large and small diameter vessels. In this work, two chemotherapeutics used in the treatment of HCC, doxorubicin and sorafenib, were incorporated into the in situ gelling liquid embolic composed of a silk-elastinlike protein polymer (SELP-815 K). The base forms of the drugs had no significant effect on the viscosity, the gelation kinetics, and the gel stiffness of the SELP: all properties essential for the successful performance of an injectable liquid embolic. In vitro release studies indicated that the SELP liquid embolic delivered doxorubicin and sorafenib, either alone or in combination, at therapeutically relevant concentrations for a minimum of 14 and 30 days, respectively.
The development of biological preparative techniques for light microscopy, 1839–1989 (1989)

SUMMARY The development of techniques of preparing biological material for microscopical observation is summarized, with much greater emphasis being given to the introduction and establishment of the various techniques, largely in the nineteenth century, than to their perfection and extremely widespread use in the twentieth century. The development of the microtome as an instrument of the greatest importance is summarized and an assessment is made of the impact of preparative techniques on the development of the medical sciences.
Uploader Intent for Online Video: Typology, Inference, and Applications (2015)

We investigate automatic inference of uploader intent for online video, i.e., prediction of the reason for which a user has uploaded a particular video to the Internet. Users upload video for specific reasons, but rarely state these reasons explicitly in the video metadata. Information about the reasons motivating uploaders has the potential ultimately to benefit a wide range of application areas, including video production, video-based advertising , and video search. In this paper, we apply a combination of social-Web mining and crowdsourcing to arrive at a typology that characterizes the uploader intent of a broad range of videos. We then use a set of multimodal features, including visual semantic features, found to be indicative of uploader intent in order to classify videos automatically into uploader intent classes. We evaluate our approach on a dataset containing ca. 3K crowdsourcing-annotated videos and demonstrate its usefulness in prediction tasks relevant to common application areas.
Kotani's Theorem for the Fourier Transform (2020)

In 1991, Shinichi Kotani proved a theorem giving a sufficient condition to conclude that a function $f(x)$ on ${\mathbb Z}^d$ decays like $|x|^{-(d-2)}$ for large $x$, assuming that its Fourier transform $\hat f(k)$ is such that $|k|^{2}\hat f(k)$ is well behaved for $k$ near zero. The proof was not published. We prove an extension of Kotani's Theorem, based on Kotani's unpublished proof.
Transplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee (2002)

We investigated the clinical, arthroscopic and biomechanical outcome of transplanting autologous chondrocytes, cultured in atelocollagen gel, for the treatment of full-thickness defects of cartilage in 28 knees (26 patients) over a minimum period of 25 months. Transplantation eliminated locking of the knee and reduced pain and swelling in all patients. The mean Lysholm score improved significantly. Arthroscopic assessment indicated that 26 knees (93%) had a good or excellent outcome. There were few adverse features, except for marked hypertrophy of the graft in three knees, partial detachment of the periosteum in three and partial ossification of the graft in one. Biomechanical tests revealed that the transplants had acquired a hardness similar to that of the surrounding cartilage. We conclude that transplanting chondrocytes in a newly-formed matrix of atelocollagen gel can promote restoration of the articular cartilage of the knee.
Aquasomes - A self assembled nanotechnology system (2011)

Aquasomes are one of the most recently developed delivery systems; these are nanoparticulate carrier systems with three-layered self-assembled structures. They comprise a central solid nanocrystalline core coated with polyhydroxyoligomers onto which biochemically active molecules are adsorbed. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. The brushite is unstable and converts to hydroxyapatite upon prolong storage. Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes. It is widely used for the preparation of implants for drug delivery. The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide, protein, hormones, antigens and genes to specific sites.
Attribute certification (1999)

In order to implement role-based controls in operational environments, they must be represented and managed in a secure manner, desirably leveraging other security infrastructure elements.
Image retrieval by examples (2000)

A currently important research field in information sciences is the management of nontraditional distributed multimedia databases. Two related key issues are to achieve an efficient content-based query by example retrieval and a fast response time. This paper presents the architecture of a distributed image retrieval system which provides novel solutions to these key issues. In particular, a method to quantify the effectiveness of low level visual descriptors in database query tasks is presented. The results are also used to improve the system response time, which is an important issue when querying very large databases. A new mechanism to adapt system query strategies to user behavior is also introduced in order to improve the effectiveness of relevance feedback and overall system response time. Finally, the issue of browsing multiple distributed databases is considered and a solution is proposed using multidimensional scaling techniques.
Synthesis and Lithium Ion Conduction of Polysiloxane Single-Ion Conductors Containing Novel Weak-Binding Borates (2012)

Three borate monomers: lithium triphenylstyryl borate (B1), a variant with three ethylene oxides between the vinyl and the borate (B2) and a third with perfluorinated phenyl rings (B3) were synthesized and used to prepare polysiloxane ionomers based on cyclic carbonates via hydrosilylation. B1 ion content variations show maximum 25 °C conductivity at 8 mol %, reflecting a trade-off between carrier density and glass transition temperature (Tg) increase. Ethylene oxide spacers (B2) lower Tg, and increase the dielectric constant, both raising conductivity. Perfluorinating the four phenyl rings (B3) lowers the ion association energy, as anticipated by ab initio estimations. This increases conductivity, a direct result of 3 times higher measured carrier density. The ∼9 kJ/mol activation energy of simultaneously conducting ions is less than half that of ionomers with either sulfonate or bis(trifluoromethanesulfonyl) imide anions, suggesting that ionomers with weak-binding borate anions may provide a pathway to useful single-ion Li+ conductors, if their Tg can be lowered.
Self-Healing Hydrogels Formed by Complexation between Calcium Ions and Bisphosphonate-Functionalized Star-Shaped Polymers (2017)

Star-shaped poly(ethylene glycol) (PEG) chain termini were functionalized with alendronate to create transient networks with reversible crosslinks upon addition of calcium ions. The gelation ability of alendronate-functionalized PEG was greatly dependent on the number of arms and arm molecular weight. After mixing polymer and calcium solutions, the formed hydrogels could be cut and then brought back together without any visible interface. After 2 minutes of contact, their connection was strong enough to allow for stretching without tearing through the previous fracture surface. Oscillatory rheology showed that the hydrogels recovered between 70 and 100% of the original storage and loss modulus after rupture. Frequency sweep measurements revealed a liquid-like behavior at lower frequencies and solid-like at high frequencies. Shifting frequency curves obtained at different calcium and polymer concentrations, all data collapsed in a single common master curve. This time-concentration superposition reveals a common relaxation mechanism intrinsically connected to the calcium-bisphosphonate complexation equilibrium.
A feedback based scheme for improving TCP performance in ad-hoc wireless networks (2002)

Ad-hoc networks are completely wireless networks of mobile hosts, in which the topology rapidly changes due to the movement of mobile hosts. This frequent topology may lead to sudden packet losses and delays. Transport protocols like TCP have been built mainly for reliable, fixed networks. Hence, when used in ad-hoc networks, TCP misinterprets this loss as congestion and invokes congestion control. This leads to unnecessary retransmissions and loss of throughput. To overcome this problem, a feedback scheme is proposed, so that the source can distinguish between route failure and network congestion. When a route is disrupted, the source is sent a route failure notification (RFN) packet, allowing it to freeze its timers and stop sending packets. When the route is re-established, the source is informed through a route re-establishment notification (RRN) packet, upon which it resumes by unfreezing timers and continuing packet transmissions. The simulated performance of TCP on ad-hoc networks with and without feedback is compared and reported. It is observed that in the event of route failures, as the route re-establishment time increases, the use of feedback provides significant gains in throughput as well as savings in unnecessary packet transmissions. Several further enhancements and directions for future work are also sketched.
Thermal Insulation With Latent Energy Storage for Flow Assurance in Subsea Pipelines (2015)

Flow assurance is critical in offshore oil and gas production. Thermal insulation is an effective way to reduce heat loss from subsea pipelines and avoid the formation of hydrates or wax deposits that could block the flowlines. This paper presents heat transfer analysis from a subsea flowline with different insulation materials, particularly with nano-enhanced phase change materials (NPCMs) that allow thermal energy storage in the pipeline system. The phase change materials (PCMs) can effectively regulate fluid temperature during production fluctuations or increase the cool-down time during production shutdown. This paper considers a pipe in pipe configuration with different insulation methods; the cool-down times are calculated and compared. The results show that thermal insulation can greatly delay the fluid cool-down process. A significant improvement of cool-down time can be achieved with PCM energy storage under a good conventional insulation layer. Moreover, with nanoparticles in a PCM, the latent energy storage is enhanced thus it takes even longer time for the internal fluid to reach its hydrate formation temperature.
A 2 to 8 GHz Leveling Loop Using a GaAs MMIC Active Splitter and Attenuator (1986)

A wide-band monolithic GaAs bridged-T variable attenuator has been used with a monolithic GaAs active power splitter to form a compact, 2 to 8 GHz leveling loop for RF sources having a minimum 12dB leveling range with buffered output. The attenuator internally optimizes input and output return loss over a 1 to 10 GHz bandwidth by the use of an on-chip GaAs op-amp. The active power splitter provides unity gain to each port over a 1 to 10 GHz bandwidth by the use of distributed amplification. The entire 4.5 cm by 42 cm subsystem was realized with surface mount packages on RT-Duroid®®.