gebhart/patrepeval huggingface dataset:
Mapping the immunodeterminants of the complete streptococcal M6 protein molecule. Identification of an immunodominant region. (1988)

The immune response to the complete streptococcal M6 protein was examined by kinetic ELISA to determine the reactivity of rabbit and human sera to M6 peptides representing 82% of the native molecule. The results revealed that rabbits immunized with purified native M6 protein or whole streptococci responded by reacting early and predominantly to one of the three sequence repeat regions of the molecule, the B-repeat, antibodies which have been shown to be non-opsonic. Antibodies to peptides representing the hypervariable N-terminal and adjacent A-repeat regions appear when opsonic antibodies are detected in the serum. Antibodies to peptides located within the conserved C-terminal half of the molecule (proximal to the cell) were restricted even after several immunizations. An examination of human sera from individuals with no recent streptococcal infection (greater than 3 yr), revealed that those sera opsonic for M6 streptococci contained antibodies reactive predominantly to the N-terminal and A-repeat regions, supporting the view that opsonic antibodies are long lived. Nonopsonic human sera to M6 streptococci exhibited a low reactivity to all peptides. However, by Western blot analysis, all human sera tested contained antibodies to the conserved region of the molecule, whereas only sera opsonic for M6 streptococci reacted with the variable region. Evidence is presented supporting the view that antibodies to the conserved regions of the M molecule may be conformation dependent.
Culture of preimplantation embryos and its long-term effects on gene expression and phenotype (2001)

A growing number of medical, scientific and biotechnological procedures rely on culture of mammalian preimplantation embryos. This review presents currently available data on aberrant offspring development that sometimes arises from commonly applied in-vitro procedures in humans, ruminant species and mice. Comparison between mammalian species reveals similarities in the phenotypic abnormalities that are observed at fetal and perinatal stages of development. In particular, aberrant effects on fetal growth have been observed in multiple studies in which serum complemented the preimplantation culture medium. Although it remains to be determined whether there is a common causal mechanism(s) involved, several hypotheses have been put forward to account for the variety of the observed developmental abnormalities. One of these postulates that culture can result in the epigenetic deregulation of developmentally important genes, and that such epigenetic alterations would affect in particular the expression of genes that are subject to genomic imprinting. Imprinted genes play key roles in the control of fetal growth, and altered imprinting can cause growth defects. Some recent in-vitro culture studies on mice and ruminant species now lend support to this hypothesis.
Injection locking of argon-ion lasers (1984)

Using an injection-locking technique, we obtain high-power single-frequency emission from a multimode argon-ion laser. Furthermore, a phase-control loop permits the stable, coherent summation of the beams from the two lasers.
Brightness-Scaling Potential of Actively Phase-Locked Solid-State Laser Arrays (2007)

Recent progress in developing phased arrays of high-brightness solid-state lasers is summarized. We address the prospects for continued brightness-scaling via a model that extrapolates measured results to large numbers of array elements and provides a quantitative illustration of the features of coherent beam combination. This demonstrates that with present-day technology, both slab and fiber lasers have the capability to scale to unprecedented brightness levels.
Lawful interception data retention regulation recommendation: Recommendations for countries that do not have relevant regulations of this field (2011)

Since the need of the communication data in revealing the crime are just emerged after the event detected, communication data retention for lawful interception (LI) are really demanded. This paper aim to give recommendation for telecommunication regulatory body in making communication data retention regulation. This research describes points of recommendation to National Telecommunication Regulatory Body in establishing LI data retention regulation which conducted by the Communication Service Provider in the country. These recommendations are very useful for countries that do not have relevant regulations of this field. This paper suggests that propose data retention system must have an ability to run administrative function, data collection function and data management function. Each function should maintain such a log. Administrative log has to keep warrant information include target identity and date start, and the duration of data retention needed. In telecommunication infrastructure target are either MSISDN, IMEI or IMSI. For communication data through IP mechanism, target is either email address, account name or IP address. Information item that have to be retained are include subscriber data, usage data and traffic data, equipment data, network element data, additional service data and the call contents. If storage capacity are not fully provided yet, the retention for data that need the largest storage space such as video and file might be less priority. Regulatory Body must determine the data retention format based on handover interface. To prevent abuse of data, regulation should put clauses that obligate each party to delete data longer than retention period. Besides this paper recommends decentralize location of storage media, apart from operational system and have a hot site backup.
More on finding a single number to indicate overall performance of a benchmark suite (2004)

article Share on More on finding a single number to indicate overall performance of a benchmark suite Author: Lizy Kurian John The University of Texas at Austin The University of Texas at AustinView Profile Authors Info & Claims ACM SIGARCH Computer Architecture NewsVolume 32Issue 1March 2004 pp 3–8https://doi.org/10.1145/991124.991126Online:01 March 2004Publication History 36citation1,218DownloadsMetricsTotal Citations36Total Downloads1,218Last 12 Months34Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Dietary Antioxidants During Cancer Chemotherapy: Impact on Chemotherapeutic Effectiveness and Development of Side Effects (2000)

Several studies suggest that dietary supplementation with antioxidants can influence the response to chemotherapy as well as the development of adverse side effects that results from treatment with antineoplastic agents. Administration of antineoplastic agents results in oxidative stress, i.e., the production of free radicals and other reactive oxygen species (ROS). Oxidative stress reduces the rate of cell proliferation, and that occurring during chemotherapy may interfere with the cytotoxic effects of antineoplastic drugs, which depend on rapid proliferation of cancer cells for optimal activity. Antioxidants detoxify ROS and may enhance the anticancer effects of chemotherapy. For some supplements, activities beyond their antioxidant properties, such as inhibition of topoisomerase II or protein tyrosine kinases, may also contribute. ROS cause or contribute to certain side effects that are common to many anticancer drugs, such as gastrointestinal toxicity and mutagenesis. ROS also contribute to side effects that occur only with individual agents, such as doxorubicin-induced cardiotoxicity, cisplatin-induced nephrotoxicity, and bleomycin-induced pulmonary fibrosis. Antioxidants can reduce or prevent many of these side effects, and for some supplements the protective effect results from activities other than their antioxidant properties. Certain side effects, however, such as alopecia and myelosuppression, are not prevented by antioxidants, and agents that interfere with these side effects may also interfere with the anticancer effects of chemotherapy.
A radioimmunoassay for wheat gliadin to assess the suitability of gluten free foods for patients with coeliac disease. (1985)

Coeliac disease is a clinical condition characterised by malabsorption secondary to abnormalities of the small intestine. The condition is known to be exacerbated by wheat gliadin, rye, barley and possibly oats. The only assays that are available for testing for the presence of wheat gluten in foods are double diffusion against rabbit anti-gliadin antiserum and measurement of Kjeldahl nitrogen in products derived from wheat flour. We have developed a radioimmunoassay for wheat gliadin with a detection limit of 1 ng. Nominally gluten free foods based on wheat starch have been shown to contain up to 1.9 X 10(-2)% wheat gliadin. Bread made from Nutregen wheat starch which has now been withdrawn contains 6.4 mg gliadin per standard 30 g slice. A radioimmunoassay for wheat gliadin could be used to define standards for the suitability of gluten free products based on wheat starch for patients with coeliac disease.
The Radial Displacement of the HPT Blade under the Effects of the Temperature Field and the Centrifugal (2012)

The blade temperature field is computed using the finite element software of ANSYS and Hypermesh. The radial displacement response under the temperature field and centrifugal is analyzed. And a new method of plotting the grid and loading the boundary for complicated three-dimensional model in the finite element software is advanced. The heat transfer coefficients at different parts of the blade are introduced. The results show that for the temperature circumference distribution of the blade profile, the temperature is the highest at the leading and trailing edges and low at the middle. For the radial distribution the temperature is low at the blade root, and high at the blade profile and the integral tip shroud. The effect of temperature field is the main reason of the blade radial displacement while the centrifugal effect accounts for little.
Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells (2015)

Allogeneic hematopoietic cell transplant (allo-HCT) can be curative for certain hematologic malignancies, but the risk of graft-versus-host disease (GVHD) is a major limitation for wider application. Ideally, strategies to improve allo-HCT would involve suppression of T lymphocytes that drive GVHD while sparing those that mediate graft-versus-malignancy (GVM). Recently, using a xenograft model, we serendipitously discovered that myxoma virus (MYXV) prevented GVHD while permitting GVM. In this study, we show that MYXV binds to resting, primary human T lymphocytes but will only proceed into active virus infection after the T cells receive activation signals. MYXV-infected T lymphocytes exhibited impaired proliferation after activation with reduced expression of interferon-γ, interleukin-2 (IL-2), and soluble IL-2Rα, but did not affect expression of IL-4 and IL-10. MYXV suppressed T-cell proliferation in 2 patterns (full vs partial) depending on the donor. In terms of GVM, we show that MYXV-infected activated human T lymphocytes effectively deliver live oncolytic virus to human multiple myeloma cells, thus augmenting GVM by transfer of active oncolytic virus to residual cancer cells. Given this dual capacity of reducing GVHD plus increasing the antineoplastic effectiveness of GVM, ex vivo virotherapy with MYXV may be a promising clinical adjunct to allo-HCT regimens.
Robust multi-stage approach for the detection of moving target from infrared imagery (2012)

We present a multi-stage classification approach to detect targets in widely varying thermal imagery. A multi-level spatial-temporal median filter is utilized to extract the background frame, with which the background clutters are suppressed by using the principal component analysis technique. A spatially related fuzzy adaptive resonance theory (ART) neural network is then applied to identify the local regions-of-interest. Within each region, another fuzzy ART neural network is utilized to detect the targets. Experimental results demonstrate that the proposed approach is capable of detecting infrared moving targets effectively for F1 measurement up to 96.3%.
Reversible Formation and Eradication of Colors by Irradiation at Low Temperatures. A Photochemical Memory Model (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible Formation and Eradication of Colors by Irradiation at Low Temperatures. A Photochemical Memory ModelYehuda HirshbergCite this: J. Am. Chem. Soc. 1956, 78, 10, 2304–2312Publication Date (Print):May 1, 1956Publication History Published online1 May 2002Published inissue 1 May 1956https://pubs.acs.org/doi/10.1021/ja01591a075https://doi.org/10.1021/ja01591a075research-articleACS PublicationsRequest reuse permissionsArticle Views1898Altmetric-Citations248LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Truncation artifact suppression in cone-beam radionuclide transmission CT using maximum likelihood techniques: evaluation with human subjects (1992)

Transverse image truncation can be a serious problem for human imaging using cone-beam transmission CT (CB-CT) implemented on a conventional rotating gamma camera. If this problem can be solved, CB-CT will be useful for attenuation compensation of SPECT images. This paper presents a reconstruction method to reduce or eliminate the artifacts resulting from the truncation. The method uses a previously published transmission maximum likelihood EM algorithm, adapted to the cone-beam geometry. The reconstruction method is evaluated qualitatively using three human subjects of various dimensions and various degrees of truncation. For the two smaller subjects, with moderate truncation, the maximum likelihood method is very successful, nearly eliminating the artifacts seen with conventional filtered backprojection of truncated geometries. The use of an expanded reconstructed space, which contains the entire transverse slice of the subject, is necessary for optimal truncation removal. For the largest subject investigated, the truncation was substantial, and the artifacts were only partially removed by the maximum likelihood reconstruction. Nonetheless, the images were qualitatively superior to those obtained with filtered backprojection. An added elliptical support prior moderately increased the rate of convergence, and helped to force a reasonable body contour.
Thermally stable ohmic contacts to <i>n</i>-type GaAs. VII. Addition of Ge or Si to NiInW ohmic contacts (1990)

The effects of Si or Ge addition to NiInW ohmic contacts on their electrical behavior were studied, where the samples were prepared by evaporating Ni(Si) or Ni(Ge) pellets with In and W and annealed by a rapid thermal annealing method. An addition of Si affected the contact resistances of NiInW contacts: the resistances decreased with increasing the Si concentrations in the Ni(Si) pellets and the lowest value of ∼0.1 Ω mm was obtained in the contact prepared with the Ni-5 at. % Si pellets after annealing at temperatures around 800 °C. The contact resistances did not deteriorate during isothermal annealing at 400 °C for more than 100 h, far exceeding process requirements for self-aligned GaAs metal-semiconductor field-effect-transistor devices. In addition, the contacts were compatible with TiAlCu interconnects which have been widely used in the current Si process. Furthermore, the addition of Si to the NiInW contacts eliminated an annealing step for activation of implanted dopants and low resistance (∼0.2 Ω mm) contacts were fabricated for the first time by a ‘‘one-step’’ anneal. In contrast, an addition of Ge to the NiInW contacts did not significantly reduce the contact resistances.
Appearance frequency modulated gene set enrichment testing (2011)

We introduce an alternative way to integrate KEGG PATHWAY information into gene set enrichment testing. The performance of GSEA and LRpath can be enhanced with the integration of appearance frequency of genes. We conclude that, generally, gene set analysis methods with the integration of information from KEGG PATHWAY performs better both statistically and biologically.
Boost Converter With Coupled Inductors and Buck–Boost Type of Active Clamp (2008)

This paper proposes a boost converter with coupled inductors and a buck-boost type of active clamp. In the converter, the active-clamp circuit is used to eliminate the voltage spike that is induced by the trapped energy in the leakage inductor of the coupled inductors. The active switch in the converter can still sustain a proper duty ratio even under high step-up applications, reducing voltage and current stresses significantly. Moreover, since both main and auxiliary switches can be turned on with zero-voltage switching, switching loss can be reduced, and conversion efficiency therefore can be improved significantly. A 200 W prototype of the proposed boost converter was built, from which experiment results have shown that efficiency can reach as high as 92% and surge can be suppressed effectively. It is relatively feasible for low-input-voltage applications, such as fuel cell and battery power conversion.
Electromigration: the time bomb in deep-submicron ICs (1996)

Electromigration results from the movement of metal ions as current flows through power wires in integrated circuits, causing voids and hillocks in the wires. The voids increase resistance or even cause opens in the wires, while hillocks can cause shorts to adjacent wires. This paper describes how electromigration is a ticking time bomb in IC designs, which can trigger a system failure at some undefined future time. The phenomenon is particularly likely to afflict the thin, tightly spaced power-distribution lines of deep-submicron designs.
Minimizing Energy Consumption via Sleep Mode in Green Base Station (2010)

In this paper, we develop new energy-efficient, radio resource management schemes for green wireless networks. Our goal is to optimize energy consumption at the network scale while preserving the Quality of Service (QoS) perceived by users. We specifically propose two new sleep mechanisms for base station where a number of resources in system can be shut down for some traffic scenarios in one of two ways: a dynamic way where resources are activated/deactivated in real-time as a function of the instantaneous load of the system, and a semi-static one where resources are kept unchanged during longer time intervals, in the order of one hour. We apply the proposed schemes to 2G and HSPA (High Speed Packet Access) systems and show that the dynamic one achieves larger energy reductions while the semi-static one has an acceptable performance with low complexity.
Small-aperture radio direction-finding (1991)

Operating principles performance definition DF error sources system level descriptions representative operational small-aperture DF systems passive geolocation sub-system considerations calibratin and test of DF systems spread-spectrum direction finding.
Surface-Enhanced Raman Scattering Active Substrates (2011)

New SERS active substrates were successfully prepared for the identification of Staphylococcus aureus and R6G. The surface-enhancement effect by the substrates enables rapid identification of bacteria and chemical species. The enhancement capability can be controlled by tuning the surface roughness of the substrates through varying treatment durations.
Functional architecture of long-range perceptual interactions (1999)

The pattern of lateral interactions in the primary visual cortex, which has emerged from recent studies, conforms to the grouping rules of similarity, proximity, smoothness and closure. The goal of this paper is to understand the perceptual salience of oriented elements that are specifically organized to form a smooth contour. An overview of recent studies, in combination with new experimental results, is presented here to emphasis the idea that visual responses depend on input from both the center and the surround of the classical receptive field (CRF). It is assumed that normal lateral interactions produce a neuronal network that is formed by two antagonistic mechanisms: (i) excitation, that is spatially organized along the optimal orientation (collinear), and is predominant near the contrast threshold of the neuron, and (ii) inhibition, that is less selective and is distributed diffusely around the cell's response field. Thus, the inputs from the CRF and the anisotropic surround are summated non-linearly. The specificity of the facilitation and suppression along the collinear direction suggests the existence of second-order elongated collinear filters, which may increase the response similarity between neurons responding to elongated stimulus, thus may enhance the perceptual salience of anisotropic configurations such as contours. This causal connection is particularly evident in amblyopes, where abnormal development of the network results in the abnormal perception of contours.
Two-liquid phase biocatalytic reactors (1983)

Abstract Two-liquid phase biocatalytic reactors in which a large proportion of the reaction volume is occupied by the organic phase have been investigated for steroid transformations and the modification of oils and fats. The organic phase may consist of the reactant alone or the reactant dissolved in a water-immiscible organic solvent. Under appropriate conditions, immobilized cells and enzymes have reasonable operational stabilities in such reactors, and some commercial processes are being developed.