gebhart/patrepeval huggingface dataset:
Linearity Improvement Techniques for Wireless Transmitters: Part 2 (2009)

By Andrei GrebennikovBell Labs IrelandReflect ForwardLinearization AmplifierThe reflect forwardadaptive linearizer(RFAL) technique usesthe input reflected signalfrom one power amplifierto develop an intermodu-lation-correcting signalforwarded to the input of the other poweramplifier which are connected in parallel orbalanced configuration [23, 24]. Figure 6shows a block diagram of the RFAL amplifierwhich includes the two identical power ampli-fiers, a low-distortion booster amplifier, for-ward and reflected paths with two directionalcouplers at the input, and delay line and in-phase combiner at the output. With the RFALtechnique, the power combining efficiency ofthe two power amplifiers approaches that ofthe conventional parallel power amplifier con-figuration, while the intermodulation prod-ucts can be improved from 20 to 30 dBc at thecenter bandwidth frequency.The basic principle of RFALoperation can be described as fol-lows: when the two-tone forwardfundamental signal is reflectedfrom the transistor input of upperpower amplifier, the resultingreflected two-tone fundamental sig-nal is out-of-phase relative to theinput forward signal and is in-phase relative to the output signal.In this case, the intermodulationcomponents appeared at the upperpower amplifier input as a result ofits active device nonlinearity are in-phase relative to the output inter-modulation components. The input reflectedcomposite signal containing the fundamentaland intermodulation components is used as acorrecting signal for the lower power amplifi-er. This correcting signal, when properlyamplified and phased in the reflected path,cancels the output intermodulation distor-tions produced by the lower power amplifierwhen it is combined with the input signalflowing through the forward path.The boosteramplifier in a lower path is necessary toequalize the drive signal levels for both upperand lower power amplifiers. In this case, thesignals from the upper and lower amplifyingpaths have the in-phase fundamental and out-of-phase intermodulation components at thecorresponding inputs of the output in-phasecombiner, thus resulting in a distortion can-cellation in the combined signal flowing intothe load. The LDMOS RFAL amplifier withoutput power of 43 dBm achieves an improve-ment of the third-order intermodulation prod-ucts by over 15 dB and a total efficiency ofmore than 20% over the frequency range fromThis two-part article presents a wide range oftechniques for amplifier linearization, along with historical notes to help usappreciate the creativework in their development Figure 6 · Block schematic of reflect forward lineariza-tion amplifier.From June 2009
A dengue DNA vaccine formulated with Vaxfectin<sup>®</sup>is well tolerated, and elicits strong neutralizing antibody responses to all four dengue serotypes in New Zealand white rabbits (2012)

A tetravalent DNA vaccine formulated with Vaxfectin adjuvant was shown to elicit high levels of neutralizing antibody against all four dengue virus serotypes (Porter et al., ( 16) ), warranting further testing in humans. In preparation for a phase 1 clinical testing, the vaccine and the adjuvant were manufactured under current good manufacturing practice guidelines. The formulated vaccine and the adjuvant were tested for safety and/or immunogenicity in New Zealand white rabbits using a repeat dose toxicology study. The formulated vaccine and the adjuvant were found to be well tolerated by the animals. Animals injected with formulated vaccine produced strong neutralizing antibody response to all four dengue serotypes.
Energy-Efficient Thermal-Aware Task Scheduling for Homogeneous High-Performance Computing Data Centers: A Cyber-Physical Approach (2008)

High-performance computing data centers have been rapidly growing, both in number and size. Thermal management of data centers can address dominant problems associated with cooling such as the recirculation of hot air from the equipment outlets to their inlets and the appearance of hot spots. In this paper, we show through formalization that minimizing the peak inlet temperature allows for the lowest cooling power needs. Using a low-complexity linear heat recirculation model, we define the problem of minimizing the peak inlet temperature within a data center through task assignment (MPIT-TA), consequently leading to minimal cooling-requirement. We also provide two methods to solve the formulation: Xlnt-GA, which uses a genetic algorithm, and Xlnt-SQP, which uses sequential quadratic programming. Results from small-scale data center simulations show that solving the formulation leads to an inlet temperature distribution that, compared to other approaches, is 2 degC to 5 degC lower and achieves about 20 to 30 percent cooling energy savings at common data center utilization rates. Moreover, our algorithms consistently outperform the minimize heat recirculation algorithm, a recirculation-reducing task placement algorithm in the literature.
Layout design of on-chip transformer with uniform variation of coil widths (2009)

A novel layout of variable width transformer is proposed to minimize the metal resistance in this study. Compared with reported paper [1], the sophisticated approach obtains a local minimum by equalizing the width ratio of primary and secondary coils. Two on-chip transformers with identical self inductance and chip area are fabricated to verify the proposed algorithm in CMOS technology. Measurement results demonstrate that the improvement of metal resistance approximates to the value of 10.36 %.
Studies on the immune response and preparation of antibodies against a large panel of conjugated neurotransmitters and biogenic amines: specific polyclonal antibody response and tolerance (2009)

We described the production and characterization of antibodies against three important groups of neuro-active haptens, e.g., neurotransmitters and biogenic amines. First, from the tryptophane metabolic pathway: tryptamine, serotonin, 5-hydroxy-indole acetic acid, and melatonin. Secondly, the tyrosine metabolic pathway: tyramine, dopamine, dihydroxyphenyl acetic acid, and norepinephrine. Thirdly, antibodies against excitatory and inhibitory neurotransmitters: glycine, glutamate, glutamine, and GABA. Immunogenic conjugates were prepared after linking haptens to carrier proteins. Most antibodies displayed high specificity against corresponding neuro-active haptens conjugated in vitro and in situ in biological specimens, but not to closely related conjugated metabolites, precursors, pharmaceuticals, agonists, antagonists, or free neuro-active haptens. Conjugated norepinephrine was highly tolerant in different animal species and produced incidentally a short specific antibody response.
Stabilization of the α2 Isoform of Na,K-ATPase by Mutations in a Phospholipid Binding Pocket (2011)

The α2 isoform of Na,K-ATPase plays a crucial role in Ca(2+) handling, muscle contraction, and inotropic effects of cardiac glycosides. Thus, structural, functional, and pharmacological comparisons of α1, α2, and α3 are of great interest. In Pichia pastoris membranes expressing human α1β1, α2β1, and α3β1 isoforms, or using the purified isoform proteins, α2 is most easily inactivated by heating and detergent (α2 ≫ α3 > α1). We have examined an hypothesis that instability of α2 is caused by weak interactions with phosphatidylserine, which stabilizes the protein. Three residues, unique to α2, in trans-membrane segments M8 (Ala-920), M9 (Leu-955), and M10 (Val-981) were replaced by equivalent residues in α1, singly or together. Judged by the sensitivity of the purified proteins to heat, detergent, "affinity" for phosphatidylserine, and stabilization by FXYD1, the triple mutant (A920V/L955F/V981P, called α2VFP) has stability properties close to α1, although single mutants have only modest or insignificant effects. Functional differences between α1 and α2 are unaffected in α2VFP. A compound, 6-pentyl-2-pyrone, isolated from the marine fungus Trichoderma gamsii is a novel probe of specific phospholipid-protein interactions. 6-Pentyl-2-pyrone inactivates the isoforms in the order α2 ≫ α3 > α1, and α2VFP and FXYD1 protect the isoforms. In native rat heart sarcolemma membranes, which contain α1, α2, and α3 isoforms, a component attributable to α2 is the least stable. The data provide clear evidence for a specific phosphatidylserine binding pocket between M8, M9, and M10 and confirm that the instability of α2 is due to suboptimal interactions with phosphatidylserine. In physiological conditions, the instability of α2 may be important for its cellular regulatory functions.
Review of Fricke gel dosimeters (2004)

The innovation of adding a gel matrix to the traditional Fricke dosimeter to stabilize geometric information established the field of gel dosimetry for radiation therapy. A discussion of Fricke gels provides an overview of the issues that determine the dose response of all gel dosimeters in general. In this paper we review some of the features of Fricke systems to illustrate these issues and, in addition, to motivate renewed clinical interest in Fricke gels.
A 16b microprocessor for realtime applications (1983)

A 160K transistor/16b microprocessor, using a 20MHz clock which executes additions in 200ns and multiplies in 1.85μs, will be discussed. The chip (128K mil <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> L) includes floating point instructions, 16 levels of interrupt and two timers.
Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase (1998)

We recently reported that macrophages and fibroblasts secrete a Zn2+-dependent sphingomyelinase (S-SMase), which, like lysosomal SMase, is a product of the acid SMase gene. S-SMase may cause subendothelial retention and aggregation of lipoproteins during atherogenesis, and the acid SMase gene has been implicated in ceramide-mediated cell signaling, especially involving apoptosis of endothelial cells. Because of the central importance of the endothelium in each of these processes, we now sought to examine the secretion and regulation of S-SMase by vascular endothelial cells. Herein we show that cultured human coronary artery and umbilical vein endothelial cells secrete massive amounts of S-SMase (up to 20-fold more than macrophages). Moreover, whereas S-SMase secreted by macrophages and fibroblasts is almost totally dependent on the addition of exogenous Zn2+, endothelium-derived S-SMase was partially active even in the absence of added Zn2+. Secretion of S-SMase by endothelial cells occurred both apically and basolaterally, suggesting an endothelial contribution to both serum and arterial wall SMase. When endothelial cells were incubated with inflammatory cytokines, such as interleukin-1beta and interferon-gamma, S-SMase secretion by endothelial cells was increased 2-3-fold above the already high level of basal secretion, whereas lysosomal SMase activity was decreased. The mechanism of interleukin-1beta-stimulated secretion appears to be through increased routing of a SMase precursor protein through the secretory pathway. In summary, endothelial cells are a rich and regulatable source of enzymatically active S-SMase, suggesting physiologic and pathophysiologic roles for this enzyme.
Properties of honeycomb polyester knitted fabrics (2016)

The properties of honeycomb polyester weft-knitted fabrics were studied to understand their advantages. Seven honeycomb polyester weft-knitted fabrics and one common polyester weft-knitted fabric were selected for testing. Their bursting strengths, fuzzing and pilling, air permeability, abrasion resistance and moisture absorption and perspiration were studied. The results show that the honeycomb polyester weft-knitted fabrics have excellent moisture absorption and liberation. The smaller their thicknesses and area densities are, the better their moisture absorption and liberation will be. Their anti-fuzzing and anti-pilling is good, whereas their bursting strengths and abrasion resistance are poorer compared with common polyester fabric's. In order to improve the hygroscopic properties of the fabrics, the proportion of the honeycomb microporous structure modified polyester in the fabrics should not be less than 40%.
Synthesis and stereochemistry of amino alcohols and derivatives in the 2-amino-.alpha.-phenylcyclohexanemethanol series (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and stereochemistry of amino alcohols and derivatives in the 2-amino-.alpha.-phenylcyclohexanemethanol seriesJacob Szmuszkovicz and Louis L. SkaletzkyCite this: J. Org. Chem. 1967, 32, 11, 3300–3313Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/jo01286a007https://doi.org/10.1021/jo01286a007research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New Rock-Eval Method for Characterization of Unconventional Shale Resource Systems (2015)

Unconventional resources such as tight, fractured and hybrid shale gas and oil plays as well as oil or kerogen shale systems, are considered exploitable self-contained source and reservoir rocks. A better understanding of the thermal cracking of sedimentary organic matter, hydrocarbons generation, expulsion, storage and retention mechanisms constitutes a key point, estimating the oil and gas in-place, free or adsorbed, for their exploration and exploitation. Herein, we introduce a new “ready to use” method of analysis and interpretation for the Rock-Eval 6 device for better assessment of free or sorbed hydrocarbons in unconventional shale plays. This method was developed at IFP Energies nouvelles (France) and was tested on 15 actual or potential unconventional shale samples from Silurian Shale (Algeria), Mississippian Barnett Shale (USA), Early Jurassic Shale (France), Late Jurassic Bazhenov Shale (Russia) and Eocene Green River Shale at different thermal maturity stages. Results indicate a better quantification of free and/or sorbed hydrocarbons (Sh0 and Sh1 peaks) as well as a more accurate determination of the Rock-Eval Tmax maturity parameter.
Multi-channel listening-room compensation using a decoupled filtered-X LMS algorithm (2008)

Dereverberation of speech signals in a hands-free scenario by inverse filtering has been a research topic for several years now. However, it is still a challenging problem because of the nature of common room impulse responses (RIRs), which are time-variant mixed phase systems having a large number of zeros close to, on, and even outside the unit circle in the z-domain. In this contribution an adaptive multi-channel equalization algorithm based on a decoupled version of the modified filtered-X LMS (mFxLMS) will be derived in the partitioned frequency domain. This new algorithm allows for fast convergence, computationally efficient implementation, and a low system delay under realistic conditions such as ambient noise and imperfect RIR estimates.
Pixellated Cd(Zn)Te high-energy X-ray instrument (2011)

We have developed a pixellated high energy X-ray detector instrument to be used in a variety of imaging applications. The instrument consists of either a Cadmium Zinc Telluride or Cadmium Telluride (Cd(Zn)Te) detector bump-bonded to a large area ASIC and packaged with a high performance data acquisition system. The 80 by 80 pixels each of 250 μm by 250 μm give better than 1 keV FWHM energy resolution at 59.5 keV and 1.5 keV FWHM at 141 keV, at the same time providing a high speed imaging performance. This system uses a relatively simple wire-bonded interconnection scheme but this is being upgraded to allow multiple modules to be used with very small dead space. The readout system and the novel interconnect technology is described and how the system is performing in several target applications.
Fourier Analysis for Demand Forecasting in a Fashion Company (2013)

In the fashion industry, demand forecasting is particularly complex: companies operate with a large variety of short lifecycle products, deeply influenced by seasonal sales, promotional events, weather conditions, advertising and marketing campaigns, on top of festivities and socio-economic factors. At the same time, shelf-out-of-stock phenomena must be avoided at all costs. Given the strong seasonal nature of the products that characterize the fashion sector, this paper aims to highlight how the Fourier method can represent an easy and more effective forecasting method compared to other widespread heuristics normally used. For this purpose, a comparison between the fast Fourier transform algorithm and another two techniques based on moving average and exponential smoothing was carried out on a set of 4-year historical sales data of a €60+ million turnover medium- to large-sized Italian fashion company, which operates in the women's textiles apparel and clothing sectors. The entire analysis was performed on a common spreadsheet, in order to demonstrate that accurate results exploiting advanced numerical computation techniques can be carried out without necessarily using expensive software.
High speed network traffic analysis with commodity multi-core systems (2010)

Multi-core systems are the current dominant trend in computer processors. However, kernel network layers often do not fully exploit multi-core architectures. This is due to issues such as legacy code, resource competition of the RX-queues in network interfaces, as well as unnecessary memory copies between the OS layers. The result is that packet capture, the core operation in every network monitoring application, may even experience performance penalties when adapted to multi-core architectures. This work presents common pitfalls of network monitoring applications when used with multi-core systems, and presents solutions to these issues. We describe the design and implementation of a novel multi-core aware packet capture kernel module that enables monitoring applications to scale with the number of cores. We showcase that we can achieve high packet capture performance on modern commodity hardware.
Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3. (1994)

The use of 1,25-dihydroxyvitamin D3 as an antiproliferative agent in the treatment of cancer is limited by its hypercalcemic effects. Analogues with equivalent or greater antiproliferative activities but smaller hypercalcemic effects have been developed. The antiproliferative effects of 1,25-dihydroxyvitamin D3 and four analogues were studied in HT-29 and SW620 human colon cancer cell lines, moderate and low expressors of the vitamin D receptor, respectively. HT-29 is a primary, moderately differentiated, cell line, while SW620 is metastatic and poorly differentiated. Growth curve studies, proliferation assays, and clonogenic assays were used to assess the antiproliferative effects of 1,25-dihydroxyvitamin D3, 1,25-dihydroxy-16-ene-23-yne-D3, 1,25-dihydroxy-26,27-hexafluoro-16-ene-23-yne-D3, 1,25-dihydroxy-16,23E-diene-26,27-hexafluoro-D3, and 1,25-dihydroxy-16,23Z-diene-26,27-hexafluoro-D3. Growth of HT-29 cells was significantly inhibited by all four analogues at 10(-8) M (P < 0.05). Analogues 1,25-dihydroxy-26,27-hexafluoro-16-ene-23-yne-D3, 1,25-dihydroxy-16,23E-diene-26,27-hexafluoro-D3, and 1,25-dihydroxy-16,23Z-diene-26,27-hexafluoro-D3 were 2 times as potent as analogue 1,25-dihydroxy-16-ene-23-yne-D3 and 1,25-dihydroxyvitamin D3. SW620 cells did not show any growth inhibition with any of the compounds tested. The affinities of the three most potent analogues for the vitamin D receptor were similar to that of 1,25-dihydroxyvitamin D3, while that of analogue 1,25-dihydroxy-16-ene-23-yne-D3 was lower. These results demonstrate that, as in leukemic cells, analogues of 1,25-dihydroxyvitamin D3 are potent antiproliferative agents in colon cancer cells and this activity is most likely mediated through the vitamin D receptor.
Trifolitoxin Production and Nodulation Are Necessary for the Expression of Superior Nodulation Competitiveness by <i>Rhizobium leguminosarum</i> bv. <i>trifolii</i> Strain T24 on Clover (1987)

Rhizobium leguminosarum bv. trifolii T24 is ineffective in symbiotic nitrogen fixation, produces a potent antibiotic (referred to here as trifolitoxin) that is bacteriostatic to certain Rhizobium strains, and is very competitive for clover root nodulation (EA Schwinghamer, RP Belkengren 1968 Arch Mikrobiol 64: 130-145). The primary objective of this work was to demonstrate the roles of nodulation and trifolitoxin production in the expression of nodulation competitiveness by T24. Unlike wildtype T24, transposon mutants of T24 lacking trifolitoxin production were unable to decrease clover nodulation by an effective, trifolitoxin-sensitive strain of R. leguminosarum bv. trifolii. A non-nodulating transposon mutant of T24 prevented clover nodulation by a trifolitoxin-sensitive R. leguminosarum bv. trifolii when co-inoculated with a T24 mutant lacking trifolitoxin production. Neither mutant alone prevented nodulation by the trifolitoxin-sensitive strain. These results demonstrate that trifolitoxin production and nodulation are required for the expression of nodulation competitiveness by strain T24. A trifolitoxin-sensitive strain of R. meliloti did not nodulate alfalfa when co-inoculated with T24 and a trifolitoxin-resistant strain of R. meliloti. Thus, a trifolitoxin-producing strain was useful in regulating nodule occupancy on a legume host other than clover. Trifolitoxin production was constitutive in both minimal and enriched media. Trifolitoxin was found to inhibit the growth of 95% of all strains of R. leguminosarum bvs. trifolii, viceae, and phaseoli tested. Strains of all 13 biotypes of R. leguminosarum bv. trifolii were inhibited by trifolitoxin. Three strains of R. fredii were also inhibited. Strain T24 ineffectively nodulated 46 clover species, did not nodulate Trifolium ambiguum, and induced partially effective nodules on Trifolium micranthum. Since T24 produced partially effective nodules on T. micranthum and since a trifolitoxin-minus mutant of T24 induced ineffective nodules, trifolitoxin production is not the cause of the symbiotic ineffectiveness of T24.
Spectral tuning of ArF and KrF discharge lasers (1978)

Simple prism tuning of a well-passivated double-discharge excimer laser has resulted in tuning ranges of better than 20 Å in both ArF and KrF. Neither tuning is continuous, being interrupted by nonlasing holes in regions of self-absorption. A two-prism dispersive chain results in a linewidth of 1–2 Å for KrF and less than 0.5 Å for ArF.