gebhart/patrepeval huggingface dataset:
The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency (1994)

The final steps in the production of the type C retroviruses include assembly of the viral core particle and release of virions from the surface of the infected cell. The core proteins are translated as part of one of two precursors, Gag and Gag/Pol, which are cleaved by a virally encoded protease. We examined the interaction between the processing of the human immunodeficiency virus type 1 Gag precursor and the membrane-based assembly and budding of virions. Our results indicate that cleavage by the viral protease is initiated at the membrane of the infected cell during virus release and that protease activity is required for virion release to occur with maximum efficiency.
Variable-Rate Fertilization for Field Crops Equipment Requirements (2009)

AE-1445
Information gathering with mobile agents for an intrusion detection system (1999)

Many network intrusion detection systems detect intrusions by concentrating all logs of target systems in a server and having the server subsequently analyze these logs. At the Information-technology Promotion Agency (IPA), we have been developing an alternate type of network intrusion detection system called IDA (Intrusion Detection Agent system), which detects intrusions with mobile agents that act by gathering information related to intrusions from target systems on a network. The mobile agents autonomously trace the origin of the break-in without the intrusion-detection server's control and also gather information from target systems. Consequently, network traffic between the target systems and the server is reduced. This paper describes how the mobile agents migrate from machine to machine within a network and details how they trace intrusions and gather and exchange information efficiently. © 1999 Scripta Technica, Syst Comp Jpn, 30(2): 31–37, 1999
Brief Exposure to 95% Oxygen Alters Surfactant Protein D and mRNA in Adult Rat Alveolar and Bronchiolar Epithelium (1999)

Surfactant protein D (SP-D), which has structural homology to C-type lectin binding regions, may play a role in host defense and has no known surfactant function. Because other surfactant proteins have been shown to be increased after prolonged periods of hyperoxia, we sought to evaluate the early effects of hyperoxia (95% O2) on expression of SP-D in the adult male rat lung. Animals were exposed to air or to 12, 36, or 60 h of 95% O2. Northern blot analysis of total lung RNA revealed marked SP-D mRNA increases at 12 h 95% O2 compared with air-exposed controls, with decreasing expression to near that of air-exposed animals by 60 h. Semiquantitative in situ RNA hybridization demonstrated parallel results, with increased numbers of labeled alveolar epithelial (AE) and bronchiolar epithelial (BE) cells at 12 h and increased intensity of labeled alveolar cells, compared with air-exposed controls. After 60 h of exposure to 95% O2, mRNA label intensity in AE and BE was decreased to levels near those seen in air-exposed animals. In contrast, Western blotting showed a decline in total lung SP-D with 95% O2 exposure, beginning at 12 h and continuing at 36 and 60 h, respectively. Semiquantitative immunohistochemistry demonstrated a decline in AE labeling parallel to the total lung Western blot results, but labeled total BE cell numbers increased (P = 0.10). Hyperoxia had differential effects on SP-D abundance in AE and BE cells, and therefore may influence the availability of SP-D to bind microbial pathogens in the airways depending on cell type and location.
Blind image deconvolution (1996)

The goal of image restoration is to reconstruct the original scene from a degraded observation. This recovery process is critical to many image processing applications. Although classical linear image restoration has been thoroughly studied, the more difficult problem of blind image restoration has numerous research possibilities. We introduce the problem of blind deconvolution for images, provide an overview of the basic principles and methodologies behind the existing algorithms, and examine the current trends and the potential of this difficult signal processing problem. A broad review of blind deconvolution methods for images is given to portray the experience of the authors and of the many other researchers in this area. We first introduce the blind deconvolution problem for general signal processing applications. The specific challenges encountered in image related restoration applications are explained. Analytic descriptions of the structure of the major blind deconvolution approaches for images then follows. The application areas, convergence properties, complexity, and other implementation issues are addressed for each approach. We then discuss the strengths and limitations of various approaches based on theoretical expectations and computer simulations.
Temperature-aware resource allocation and binding in high-level synthesis (2005)

Physical phenomena such as temperature have an increasingly important role in performance and reliability of modern process technologies. This trend will only strengthen with future generations. Attempts to minimize the design effort required for reaching closure in reliability and performance constraints are agreeing on the fact that higher levels of design abstractions need to be made aware of lower level physical phenomena. In this paper, we investigated techniques to incorporate temperature-awareness into high-level synthesis. Specifically, we developed two temperature-aware resource allocation and binding algorithms that aim to minimize the maximum temperature that can be reached by a resource in a design. Such a control scheme will have an impact on the prevention of hot spots, which in turn is one of the major hurdles in front of reliability for future integrated circuits. Our algorithms are able to reduce the maximum attained temperature by any module in a design by up to 19.6°C compared to a binding that optimizes switching power.
The histological effect of harmonic scalpel and electrocautery in lung resections. An experimental study in a rat model. (2004)

HS induces significantly less tissue damage than EC in rat lungs.
A Novel Secure Video Surveillance System Over Wireless Ad Hoc Networks (2011)

The integration of wireless communication and embedded video systems is a demanding and interesting topic which has attracted significant research efforts from the community of telecommunication. This chapter discusses the challenging issues in wireless video surveillance and presents the detailed design for a novel highly-secure video surveillance system over ad hoc wireless networks. To this end, we explore the state-of-the-art cross domains of wireless communication, video processing, embedded systems, and security. Moreover, a new media-dependent video encryption scheme, including a reliable data embedding technique and real-time video encryption algorithm, is proposed and implemented to enable the system to work properly and efficiently in an open and insecure wireless environment. Extensive experiments are conducted to demonstrate the advantages of the new systems, including high security guarantee and robustness. The chapter would serve as a good reference for solving the challenging issues in wireless multimedia and bring new insights on the interaction of different technologies within the cross application domain.
Callus Stimulation in Distraction Osteogenesis (2002)

Distraction osteogenesis has been described as in vivo tissue engineering. The ability to stimulate this process for the repair of bony defects or lengthening of congenitally shortened facial structures is likely to significantly impact the field of craniofacial surgery. The purpose of this study was to determine whether mechanical stimulation of the distracted rabbit mandible would accelerate the maturation of the bony callus when applied during the early consolidation period. Twenty adult New Zealand White rabbits underwent unilateral mandibular osteotomy. A uni-directional internal distractor device (Synthes, Paoli, Pa.) was positioned along a plane perpendicular to the line of osteotomy. After a 7-day latency period, distraction was commenced at a rate of 1.0 mm/day for 12 days in all animals. In a control group of 10 rabbits, a consolidation period of 8 weeks was observed before they were killed. In the experimental group of 10 rabbits, daily alternate compression and distraction of 1 mm (sequential compression and distraction) was performed for 3 weeks followed by a 5-week period of rigid fixation. Each animal received a dose of a fluorescent label at three different time points during the study: at the end of the distraction period, 3 weeks after the completion of the distraction phase, and 3 days before it was killed. All animals were killed 8 weeks after the completion of the distraction phase. Undecalcified histologic analysis and 3-point bending tests to failure were performed on the extracted mandibles. The results of the experimental and control groups were compared. Four animals in the control group and three animals in the experimental group were excluded from the study because of screw loosening resulting in distractor dislodgment or because of infection. On histologic analysis, cortical thickness at the center of the callus was found to be significantly greater in the experimental group compared with the control group when normalized to the contralateral hemimandible (83 percent versus 49 percent, respectively; p < 0.007). The ratio of cortical to cancellous bone in the distracted callus was uniformly found to be greater in the experimental specimens. The mineral apposition rate was calculated by using fluorescence microscopy and found to be significantly greater in the experimental group both during the period of sequential compression and distraction (3.2 microm/day versus 2.1 microm/day, p = 0.02) and after the period of sequential compression and distraction (1.4 microm/day versus 1.1 microm/day, p = 0.006). Mechanical testing revealed no significant differences in bending strength or stiffness between experimental or control groups (p = 0.54 and 0.47, respectively). This study has demonstrated that daily alternating compression and distraction of 1 mm amplitude during the early consolidation period has a stimulatory impact on callus formation with respect to osteoblastic activity, remodeling, and maturation of bone. Optimal timing and amplitude of sequential movement, long-term biomechanical differences, and molecular pathways have yet to be elucidated.
Response of digestive gland cells of freshwater mussel <i>Unio tumidus</i> to phenolic compound exposure <i>in vivo</i> (2006)

The exposure of freshwater mussels Unio tumidus to phenolic compounds (tannic, ellagic and gallic acid) in vivo caused changes in proteins and DNA function of digestive gland cells. The mussels were exposed to various concentrations of tested polyphenols (60, 200 and 500 microM) for 24 and 48 h and their antioxidant and pro-oxidant effects were determined. The number of SH-groups was quantified spectrophotometrically using Ellman's reagent. Oxidative modification of proteins increased in the digestive gland cells in a dose- and time-dependent manner. The level of nuclear DNA damage was investigated using the comet assay. The results revealed that polyphenolic acids induce single and double-strand breaks in DNA. The highest changes were observed for tannic and gallic acids and the smallest ones for ellagic acid. 1h of DNA repair process was also studied using the same method. The data obtained in this experiment demonstrate that the most effective DNA repair occurs in the cells exposed to phenolic compounds for 24h. A longer incubation (up to 48 h) does not decrease the capacity of the repair mechanism. The antioxidant activity of the tested phenols was analyzed spectrofluorimetrically using a fluorescence probe DCFH-DA (dichlorofluorescein-diacetate). The experimental data showed that the tested acids can act as antioxidants when used at higher doses (200 and 500 microM) against the reactive oxygen species present in the digestive gland cells. The most effective was ellagic acid, also applied at the smallest dose of 60 microM, in comparison with tannic and gallic acids. In conclusion, our results demonstrate that chosen water-soluble polyphenols, which are located in various plant tissues and are also found in the aquatic environment, can influence organisms living in the water. They can be exposed to these chemicals that cause morphological alterations and changes in certain physiological processes in their organs (i.e. digestive gland cells of bivalve molluscs).
Focus Is All You Need: Loss Functions for Event-Based Vision (2019)

Event cameras are novel vision sensors that output pixel-level brightness changes ("events") instead of traditional video frames. These asynchronous sensors offer several advantages over traditional cameras, such as, high temporal resolution, very high dynamic range, and no motion blur. To unlock the potential of such sensors, motion compensation methods have been recently proposed. We present a collection and taxonomy of twenty two objective functions to analyze event alignment in motion compensation approaches. We call them focus loss functions since they have strong connections with functions used in traditional shape-from-focus applications. The proposed loss functions allow bringing mature computer vision tools to the realm of event cameras. We compare the accuracy and runtime performance of all loss functions on a publicly available dataset, and conclude that the variance, the gradient and the Laplacian magnitudes are among the best loss functions. The applicability of the loss functions is shown on multiple tasks: rotational motion, depth and optical flow estimation. The proposed focus loss functions allow to unlock the outstanding properties of event cameras.
Compartmentation in the Induction of the Hexose-6-Phosphate Transport System of <i>Escherichia coli</i> (1970)

The induction of the hexose-6-phosphate transport system was investigated. Glucose-6-phosphate (G6P) at concentrations as low as 10(-4)m was able to induce this system in wild-type cells, as well as in mutants lacking phosphoglucose isomerase or G6P dehydrogenase. Growth in the presence of fructose-6-phosphate (F6P) induced the system only if the cells contained phosphoglucose isomerase. Furthermore, glucose and F6P were found to induce the system only if the extracellular concentration of G6P became appreciable in the medium as a consequence of the leakage of intracellular G6P formed from the glucose or F6P. Intracellular G6P was not an inducer even at high concentrations. The metabolism of glucose inhibited the induction of the hexose-6-phosphate transport system. Hypotheses for this compartmentalization of inducer and membrane-associated induction are presented.
Nucleophilic routes to selectively fluorinated aromatics (1999)

Selectively fluorinated aromatic compounds are of interest in many sectors. Of the methodologies used for their formation, halogen exchange is the only industrial rival to the diazonium based routes. Although many compounds can be formed by halogen exchange, the formation of meta-fluorinated species by this route is difficult. One possible method for overcoming this is fluorodenitration. Although traditionally plagued by side reactions, recent reports suggest that, with careful control of the reaction conditions, fluorodenitration could well provide a viable industrial alternative for the formation of selectively fluorinated aromatic compounds.
The emerging complexity of protein ubiquitination (2009)

Protein ubiquitination and protein phosphorylation are two fundamental regulatory post-translational modifications controlling intracellular signalling events. However, the ubiquitin system is vastly more complex compared with phosphorylation. This is due to the ability of ubiquitin to form polymers, i.e. ubiquitin chains, of at least eight different linkages. The linkage type of the ubiquitin chain determines whether a modified protein is degraded by the proteasome or serves to attract proteins to initiate signalling cascades or be internalized. The present review focuses on the emerging complexity of the ubiquitin system. I review what is known about individual chain types, and highlight recent advances that explain how the ubiquitin system achieves its intrinsic specificity. There is much to be learnt from the better-studied phosphorylation system, and many key regulatory mechanisms underlying control by protein phosphorylation may be similarly employed within the ubiquitin system. For example, ubiquitination may have important allosteric roles in protein regulation that are currently not appreciated.
The A-tree: An Index Structure for High-Dimensional Spaces Using Relative Approximation (2000)

We propose a novel index structure, A-tree (Approximation tree), for similarity search of high-dimensional data. The basic idea of the A-tree is the introduction ofVirtual BoundingRectangl # (VBRs), which contain and approximate MBRs and data objects. VBRs can be represented rathercompactl , and thus affect the tree configuration both quantitativel and qualzR%#z el .Firstl , since tree nodes caninstal lsta number of entries of VBRs, fanout of nodes becomes lomes thuslR]# to fast search. More importantl , we have a free hand in arranging MBRs and VBRs in tree nodes. In the A-trees, nodes contain entries of an MBRand its chil8z8 VBRs. Therefore, by fetching a node of an A-tree, we can obtain the information of exact position of a parent MBR and approximate position of its chil*8#R We have performed experiments using both synthetic andreal data sets. For thereal data sets, the A-tree outperforms the SR-tree and the VA-Fil in al range ofdimensional...
Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population. (1992)

We have stably expressed in CD4+ lymphoid cells the herpes simplex virus type 1 thymidine kinase (HSV1-TK) gene under the control of the human immunodeficiency virus (HIV) promoter and transactivation response element sequences. Upon HIV infection these regulatory sequences were transactivated, switching on high-level expression of HSV1-TK. This in turn caused the death of HIV-infected cells when they were cultured in the presence of acyclovir, a nucleoside analog that becomes toxic after phosphorylation by HSV1-TK. The elimination of HIV-infected cells resulted in the arrest of HIV spreading in the culture. Complete protection of HSV1-TK-expressing cells was obtained using acyclovir concentrations that are commonly detected in the plasma of patients treated for HSV1 infection. Thus, expression of this DNA construct generates a pool of CD4+ booby-trapped cells that, as a population, are resistant to HIV infection. Our data provide a rationale for the use of suicide genes in the design of gene therapy of HIV infection.
Dynamics of Capillary-Driven Flow in Open Microchannels (2011)

The dynamics of capillary-driven flow was studied for water and water–glycerol mixtures in open hydrophilic microchannels (embedded in a hydrophobic matrix). The position of the advancing meniscus was recorded as a function of time using high speed microscopy and compared with the Washburn equation. The square of the position of the liquid front increased linearly with time, as predicted by Washburn. For a channel of the same depth, irrespective of the shape of the channel cross-section (rectangular or curved), the liquid flow was faster with decreasing channel width. A modified Washburn equation, accounting for the different flow profile in the open, noncylindrical channels, was developed. The theoretical prediction was in good agreement with the experimental data for a no-slip boundary condition at the liquid–air interface.
Genetic Analysis of the Ydr1-Bur6 Repressor Complex Reveals an Intricate Balance among Transcriptional Regulatory Proteins in Yeast (2000)

A transcriptional repressor complex encoded by two essential genes, YDR1 and BUR6, was isolated from Saccharomyces cerevisiae and shown to be the functional counterpart of the human repressor complex Dr1-DRAP1. To elucidate the mechanism of repression by this complex, altered forms of Ydr1 and Bur6 were studied in vitro and in vivo. Deletion of the C-terminal 41 amino acids of Ydr1 resulted in loss of repressor activity and a growth defect, suggesting that the C-terminal domain of Ydr1 functions as a potent transcriptional repressor. A screen for extragenic suppressors of a cold-sensitive ydr1 (ydr1(cs)) mutant led to the identification of recessive mutations in the SIN4 gene, which encodes a component of the SRB-MED complex. The sin4 alleles suppressed not only ydr1(cs) mutations but also bur6(cs) mutations. In contrast, deletion of the gal11 gene, whose product is also a member of the SRB-MED complex, failed to suppress ydr1(cs) and bur6(cs) mutations, indicating that suppression is not due to general defects in the SRB-MED complex. Moreover, one of the sin4 alleles, but not the sin4 deletion, was found to specifically suppress the inviability of a ydr1 deletion, demonstrating that the essential function of Ydr1 becomes dispensable in a sin4 mutant background. Biochemical analysis of the SRB-MED complex from the sin4 suppressor strain revealed a structurally distinct form of the SRB-MED complex that lacks a subset of mediator subunits. These results define a delicate balance between positive and negative regulators of transcription operating through the Ydr1-Bur6 repressor complex.
Gas Sensors Based on Semiconducting Metal Oxide One-Dimensional Nanostructures (2009)

This article provides a comprehensive review of recent (2008 and 2009) progress in gas sensors based on semiconducting metal oxide one-dimensional (1D) nanostructures. During last few years, gas sensors based on semiconducting oxide 1D nanostructures have been widely investigated. Additionally, modified or doped oxide nanowires/nanobelts have also been synthesized and used for gas sensor applications. Moreover, novel device structures such as electronic noses and low power consumption self-heated gas sensors have been invented and their gas sensing performance has also been evaluated. Finally, we also point out some challenges for future investigation and practical application.
Interactive learning aided by JavaScript (1999)

In recent years, the use of information technology to support learning in nutrition education has moved from mainframe-based programs to PC and Internet-based systems (Wise, 1986,1998). Many lecturers are now exploring the use of the Internet and Intranets for education and this adds a new potential method for providing support to students. A search of the Internet for a technical term frequently links to pages containing notes for students. Some of these pages contain interactive elements that test whether students have learned the material. This paper is a case study that attempts to show how simple it is to build interactivity for students using JavaScript. Many programs can be written using the language Java, but the browser needs to be specially configured and considerable programming experience is required. Java is frequently confused with JavaScript, which is actually a language supported entirely within the browser itself. A browser will interpret code in JavaScript that is simply included within appropriate HTML tags on the page. JavaScript is used to provide simple interactivity and most people will have spotted its common features: buttons and text entry used on forms to provide feedback to the originators of Web pages. An advantage of JavaScript is that browsers are able to use this language, whatever the operating system, not only in Windows.DOI: 10.1080/0968776990070206