gebhart/patrepeval huggingface dataset:
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling (2012)

Hematopoietic progenitors are regulated in their respective niches by cells of the bone marrow microenvironment. The bone marrow microenvironment is composed of a variety of cell types, and the relative contribution of each of these cells for hematopoietic lineage maintenance has remained largely unclear. Osteocytes, the most abundant yet least understood cells in bone, are thought to initiate adaptive bone remodeling responses via osteoblasts and osteoclasts. Here we report that these cells regulate hematopoiesis, constraining myelopoiesis through a Gsα-mediated mechanism that affects G-CSF production. Mice lacking Gsα in osteocytes showed a dramatic increase in myeloid cells in bone marrow, spleen, and peripheral blood. This hematopoietic phenomenon was neither intrinsic to the hematopoietic cells nor dependent on osteoblasts but was a consequence of an altered bone marrow microenvironment imposed by Gsα deficiency in osteocytes. Conditioned media from osteocyte-enriched bone explants significantly increased myeloid colony formation in vitro, which was blocked by G-CSF–neutralizing antibody, indicating a critical role of osteocyte-derived G-CSF in the myeloid expansion.
Laser-induced three-dimensional photopolymerization using visible initiators and UV cross-linking by photosensitive comonomers (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaser-induced three-dimensional photopolymerization using visible initiators and UV cross-linking by photosensitive comonomersG. Sudesh Kumar and D. C. NeckersCite this: Macromolecules 1991, 24, 15, 4322–4327Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/ma00015a013https://doi.org/10.1021/ma00015a013research-articleACS PublicationsRequest reuse permissionsArticle Views428Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior (2011)

Phasic activation of dopaminergic neurons is associated with reward-predicting cues and supports learning during behavioral adaptation. While noncontingent activation of dopaminergic neurons in the ventral tegmental are (VTA) is sufficient for passive behavioral conditioning, it remains unknown whether the phasic dopaminergic signal is truly reinforcing. In this study, we first targeted the expression of channelrhodopsin-2 to dopaminergic neurons of the VTA and optimized optogenetically evoked dopamine transients. Second, we showed that phasic activation of dopaminergic neurons in freely moving mice causally enhances positive reinforcing actions in a food-seeking operant task. Interestingly, such effect was not found in the absence of food reward. We further found that phasic activation of dopaminergic neurons is sufficient to reactivate previously extinguished food-seeking behavior in the absence of external cues. This was also confirmed using a single-session reversal paradigm. Collectively, these data suggest that activation of dopaminergic neurons facilitates the development of positive reinforcement during reward-seeking and behavioral flexibility.
Impact of Oxygen Dissolved at Bottling and Transmitted through Closures on the Composition and Sensory Properties of a Sauvignon Blanc Wine during Bottle Storage (2009)

This work outlines the results from an investigation to determine the effect of the oxygen dissolved at bottling and the specific oxygen barrier properties of commercially available closures on the composition, color and sensory properties of a Bordeaux Sauvignon Blanc wine during two years of storage. The importance of oxygen for wine development after bottling was also assessed using an airtight bottle ampule. Wines were assessed for the antioxidants (SO(2) and ascorbic acid), varietal thiols (4-mercapto-4-methylpentan-2-one, 3-mercaptohexan-1-ol), hydrogen sulfide and sotolon content, and color throughout 24 months of storage. In addition, the aroma and palate properties of wines were also assessed. The combination of oxygen dissolved at bottling and the oxygen transferred through closures has a significant effect on Sauvignon Blanc development after bottling. Wines highly exposed to oxygen at bottling and those sealed with a synthetic, Nomacorc classic closure, highly permeable to oxygen, were relatively oxidized in aroma, brown in color, and low in antioxidants and volatile compounds compared to wines sealed with other closures. Conversely, wines sealed under more airtight conditions, bottle ampule and screw cap Saran-tin, have the slowest rate of browning, and displayed the greatest contents of antioxidants and varietal thiols, but also high levels of H(2)S, which were responsible for the reduced dominating character found in these wines, while wines sealed with cork stoppers and screw cap Saranex presented negligible reduced and oxidized characters.
Sputtering in a glow discharge ion source-pressure dependence: theory and experiment (1994)

A simplified theoretical expression has been developed for a glow discharge to show how the average cathode erosion rate (expressed as the number of atoms per ion of the total bombarding flux) varies with primary sputter yield, pressure, 'diffusion length' and sputtered atom 'stopping' cross section. An inverse pressure dependence is predicted which correlates well with experiment in the <1 to 3.5 Torr range. Observed sputtering efficiency variations with the discharge gas show that Xe<Kr<Ar, which is shown to be in good agreement with theoretical differences in the low-energy primary sputter yield expected on the basis of the mass of the bombarding particle flux. There is a change at higher pressures because the rate levels off and the rates for the same cathode in different gases, including N2 and He, tend to converge. It is suggested that this could be due to a change in the mechanism to self-sputtering. Under constant conditions, the erosion rates of different cathode materials still correlate quite well with the differences in their primary sputter yields.
Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein (2001)

The BCR-ABL oncogene is central in the pathogenesis of chronic myeloid leukemia (CML). Here, tandem nanospray mass spectrometry was used to demonstrate cell surface HLA-associated expression of the BCR-ABL peptide KQSSKALQR on class I-negative CML cells transfected with HLA-A*0301, and on primary CML cells from HLA-A3-positive patients. These patients mounted a cytotoxic T-lymphocyte response to KQSSKALQR that also killed autologous CML cells, and tetramer staining demonstrated the presence of circulating KQSSKALQR-specific T cells. The findings are the first demonstration that CML cells express HLA-associated leukemia-specific immunogenic peptides and provide a sound basis for immunization studies against BCR-ABL.
Design trade-offs for arrayed waveguide grating DWDM MUX/DEMUX (2000)

Emerging optical networks to carry burgeoning Internet traffic require many more optical components, and different types of components, than the initial point-to-point systems. 80 channel systems are very complex and require hundreds of discrete optical devices, as opposed to initial 4 channel systems, which only needed 10-20 discrete optical components. One approach to reducing the cost per function of optical components is through integration of multiple functions in a single package. Fairly complex integrated optical circuits have already been developed in the form of Arrayed Waveguide Gratings (AWG) for Dense Wavelength Division Multiplexing. In this paper we give an introduction to integrated optical circuits in the form of Planar Lightwave Circuits. Next we discuss the design and manufacturing of AWG. Then we detail the design trade-offs necessary to achieve desired system performance. Special emphasis is given to the causes of insertion loss and cross- talk, and the role of process control in manufacturing is highlighted.
Ultrasonic Logging Image Denoising Based on CNN and Feature Attention (2021)

Various kinds of noise will be produced during the process of ultrasonic logging in high temperature and high-pressure environment under oil wells, which is blurring the logging image. This paper presents a novel end-to-end denoising model (ULNet) based on CNN and feature attention to address this problem and remove the noise from ultrasonic logging images. Our method mainly includes feature attention, feature enhancement based on residual model and reconstruction for ultrasonic logging image. Feature enhancement based on a residual model integrates global and local features to increase the expressive ability of the denoising model. Feature attention is used to distinguish the channel feature weights, and effective for blind denoising of actual images. Kernel dilation and skip-connection is used to reduce the computational cost during training. The Noise mapping results are used to reconstruct a clean image. Comprehensive quantitative and qualitative evaluations of results for selected study datasets collected at six oil wells in China show that this model is a feasible and effective means for denoising ultrasonic logging images. Overall, ULNet shows potential for practical ultrasonic logging images denoising.
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action (1991)

We have prepared a series of cis-4-(tetrazolylakyl)piperidine-2-carboxylic acids as potent and selective N-methyl-D-aspartic acid (NMDA) receptor antagonists. NMDA antagonists may prove to be useful therapeutic agents, for instance, as anticonvulsants, in the treatment of neurodegenerative disorders such as Alzheimer's disease and in the prevention of neuronal damage that occurs during cerebral ischemia. The compounds prepared were evaluated in vitro in both receptor binding assays [( 3H]CGS-19755, [3H]AMPA, and [3H]kainic acid) and in a cortical-wedge preparation (versus NMDA, quisqualic acid, and kainic acid) to determine affinity, potency, and selectivity. The new amino acids were also evaluated in vivo for their ability to block NMDA-induced convulsions in neonatal rats and NMDA-induced lethality in mice. The most potent compound of this series, 15 (LY233053), selectively displaced [3H]CGS-19755 binding with an IC50 of 107 +/- 7 nM and selectively antagonized responses due to NMDA in a cortical-wedge preparation with an IC50 of 4.2 +/- 0.4 microM. Compound 15 blocked both NMDA-induced convulsions in neonatal rats (minimum effective dose (MED) = 20 mg/kg ip) and NMDA-induced lethality in mice (MED = 5 mg/kg ip). This is the first example of an NMDA receptor antagonist that incorporates a tetrazole moiety as an omega-acid bioisostere. These amino acid antagonists are also unique from their phosphonic acid counterparts in that they have a shorter duration of action in vivo. For the treatment of acute disorders such as stroke, where an NMDA antagonist would be administered parenterally, the shorter duration of action may be beneficial, e.g., allowing for better dosage control. The combination of potent NMDA receptor antagonism and a short duration of action may make these compounds useful therapeutic agents in the treatment of a variety of neurological disorders.
Superionics: crystal structures and conduction processes (2004)

Superionic conductors are compounds that exhibit exceptionally high values of ionic conductivity within the solid state. Indeed, their conductivities often reach values of the order of 1 Ω−1 cm−1, which are comparable to those observed in the molten state. Following Faraday's first observation of high ionic conductivity within the solids β-PbF2 and Ag2S in 1836, a fundamental understanding of the nature of the superionic state has provided one of the major challenges in the field of condensed matter science. However, experimental and theoretical approaches to their study are often made difficult by the extensive dynamic structural disorder which characterizes superionic conduction and the inapplicability of many of the commonly used approximations in solid state physics. Nevertheless, a clearer picture of the nature of the superionic state at the ionic level has emerged within the past few decades. Many different techniques have contributed to these advances, but the most significant insights have been provided by neutron scattering experiments and molecular dynamics simulations. This review will summarize the state of current knowledge concerning the crystal structures and conduction processes of superionic conductors, beginning with a comparison of the behaviour of two of the most widely studied binary compounds, AgI and β-PbF2. Each can be considered a parent of two larger families of highly conducting compounds which are related by either chemical or structural means. These include perovskite-structured oxides and Li+ containing spinel-structured compounds, which have important commercial applications in fuel cells and lightweight batteries, respectively. In parallel with these discussions, the relative importance of factors such as bonding character and the properties of the mobile and immobile ions (charge, size, polarizability, etc) in promoting the extensive lattice disorder which characterizes superionic behaviour will be assessed and the possibilities for predicting a priori which compounds will display high ionic conductivity discussed.
SHOPPING FOR HARDWARE (1987)

Shopping for Hardware is a look at some of the factors that community transportation managers should consider when planning to purchase a computer system. Disk storage space, processing speed, printers, auxiliary features, and maintenance are briefly discussed.
Functional dosimetric metrics for predicting radiation-induced lung injury in non-small cell lung cancer patients treated with chemoradiotherapy (2012)

Functional metrics are identified as reliable predictors for RILI, however, this observation still needs to be further verified using a larger sample size.
Synthesis of pyridyl isosteres of thioperamide as H3-receptor histamine antagonists (1991)

The synthesis and evaluation as H 3 -receptor histamine antagonists is described of novel isoteric analogues of thioperamide. The compounds are designed to have fewer NH groups in order to assist brain penetration. However none of the compounds is sufficiently active as an antagonist in vitro. The 2-pyridyl analogue II has K i = 13 μmol 1 -1 .
Model-driven physiological assessment of the mitral valve from 4D TEE (2009)

Disorders of the mitral valve are second most frequent, cumulating 14 percent of total number of deaths caused by Valvular Heart Disease each year in the United States and require elaborate clinical management. Visual and quantitative evaluation of the valve is an important step in the clinical workflow according to experts as knowledge about mitral morphology and dynamics is crucial for interventional planning. Traditionally this involves examination and metric analysis of 2D images comprising potential errors being intrinsic to the method. Recent commercial solutions are limited to specific anatomic components, pathologies and a single phase of cardiac 4D acquisitions only. This paper introduces a novel approach for morphological and functional quantification of the mitral valve based on a 4D model estimated from ultrasound data. A physiological model of the mitral valve, covering the complete anatomy and eventual shape variations, is generated utilizing parametric spline surfaces constrained by topological and geometrical prior knowledge. The 4D model's parameters are estimated for each patient using the latest discriminative learning and incremental searching techniques. Precise evaluation of the anatomy using model-based dynamic measurements and advanced visualization are enabled through the proposed approach in a reliable, repeatable and reproducible manner. The efficiency and accuracy of the method is demonstrated through experiments and an initial validation based on clinical research results. To the best of our knowledge this is the first time such a patient specific 4D mitral valve model is proposed, covering all of the relevant anatomies and enabling to model the common pathologies at once.
&lt;title&gt;Spectral subspace matched filtering&lt;/title&gt; (2001)

The linear matched filter has long served as a workhorse algorithm for illustrating the promise of multispectral target detection. However, an accurate description of a target's distribution usually requires expanding the dimensionality of its intrinsic signature subspace beyond what is appropriate for the matched filter. Structured backgrounds also deviate from the matched filter paradigm and are often modeled as clusters. However, spectral clusters usually show evidence of mixing, which corresponds to the presence of different materials within a single pixel. This makes a subspace background model an attractive alternative to clustering. In this paper we present a new method for generating detection algorithms based on joint target/background subspace modeling. We use it first to derive an existing class of GLF detectors, in the process illustrating the nature of the real problems that these solve. Then natural symmetries expected to be characteristic of otherwise unknown target and background distributions are used to generate new algorithms. Currently employed detectors are also interpreted using the new approach, resulting in recommendations for improvements to them.
Thalidomide and its analogues: A review of the potential for immunomodulation of fibrosis diseases and opthalmopathy (Review) (2017)

The US Food and Drug Administration approved thalidomide and its analogues for the treatment of erythema nodosum leprosum, in spite of the notoriety of reports of severe birth defects in the middle of the last century. As immunomodulatory drugs, thalidomide and its analogues have been used to effectively treat various diseases. In the present review, preclinical data about the effects of thalidomide and its analogues on the immune system are integrated, including the effects of cytokines on transdifferentiation, the anti-inflammatory effect, immune cell function regulation and angiogenesis. The present review also investigates the latest developments of thalidomide as a therapeutic option for the treatment of idiopathic pulmonary fibrosis, skin fibrosis, and ophthalmopathies.
Computationally efficient iterative multiuser detection and decoding (2002)

We describe an iterative detection and decoding scheme for the uplink in a convolutionally coded direct sequence code division multiple access (DS-CDMA) system. We consider maximum-a-posteriori (MAP) decoding and reduce the complexity through an iterative interference cancelation scheme combined with a suboptimal channel decoding algorithm. The MAP priors are updated at every iteration step. We investigate the performance of this low complexity scheme and observe that it is close to optimal.
Three-dimensional simulation of film microstructure produced by glancing angle deposition (2000)

A novel three-dimensional (3D) ballistic deposition simulator 3D-FILMS has been developed for the modeling of thin film deposition and structure. The simulator features a ballistic transport algorithm to model incident species with angular distributions appropriate to physical vapor deposition systems. Two-tiered data structuring is employed in order to enable the simulator to run using memory resources available to workstations. The simulator has been applied to a unique class of thin films grown by the technique of glancing angle deposition (GLAD). These films exhibit low bulk density due to an internal structure consisting of isolated microcolumns, which can be engineered into a variety of 3D forms. Because of their inherent 3D morphology, created by a combination of complex substrate motion and 3D shadowing, GLAD films represent an ideal test subject for 3D simulation. Scanning electron microscope images of films are presented together with simulation results, which correctly reproduce aspects of column morphology, column growth competition and extinction, and film bulk density.
The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II. (1988)

The bovine cation-independent mannose 6-phosphate receptor (CI-MPR) and the human insulin-like growth factor II (IGF-II) receptor have recently been shown to be 80% identical in their amino acid sequences as deduced from cDNA clones (Morgan, D. O., Edman, J. C., Standring, D. N., Fried, V. A., Smith, M. C., Roth, R. A., and Rutter, W. J. (1987) Nature 329, 301-307). We have studied the binding of IGF-II to affinity-purified CI-MPR in order to obtain direct evidence that the same protein binds mannose 6-phosphate-containing ligands and IGF-II. In equilibrium binding studies, the CI-MPR bound 0.95 mol of IGF-II/mol of receptor with a Kd of 0.2 nM. The pH optimum of binding was 7.4. The addition of mannose 6-phosphate did not affect binding, indicating that the two ligands interact with different binding sites on the receptor. IGF-I bound to the receptor with a much lower affinity (Kd of 0.4 microM), and insulin binding could not be detected. IGF-II did not bind to the cation-dependent mannose 6-phosphate receptor. We conclude that the cation-independent mannose 6-phosphate receptor and the IGF-II receptor are the same protein.
Ultra low-power photovoltaic MPPT technique for indoor and outdoor wireless sensor nodes (2011)

Photovoltaic (PV) energy harvesting is commonly used to power wireless sensor nodes. To optimise harvesting efficiency, maximum power point tracking (MPPT) techniques are often used. Recently-reported techniques focus solely on outdoor applications, being too power-hungry for use under indoor lighting. Additionally, some techniques have required light sensors (or pilot cells) to control their operating point. This paper describes an ultra low-power MPPT technique which is based on a novel system design and sample-and-hold arrangement, which enables MPPT across the range of light intensities found indoors and outdoors and is capable of cold-starting. The proposed sample-and-hold based technique has been validated through a prototype system. Its performance compares favourably against state-of-the-art systems, and does not require an additional pilot cell or photodiode. This represents an important contribution, in particular for sensors which may be exposed to different types of lighting (such as body-worn or mobile sensors).