gebhart/patrepeval huggingface dataset:
A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B (2005)

Von Willebrand factor (VWF) is unable to interact spontaneously with platelets because this interaction requires a conversion of the VWF A1 domain into a glycoprotein Ibalpha (GpIbalpha) binding conformation. Here, we discuss a llama-derived antibody fragment (AU/VWFa-11) that specifically recognizes the GpIbalpha-binding conformation. AU/VWFa-11 is unable to bind VWF in solution, but efficiently interacts with ristocetin- or botrocetin-activated VWF, VWF comprising type 2B mutation R1306Q, or immobilized VWF. These unique properties allowed us to use AU/VWFa-11 for the detection of activated VWF in plasma of patients characterized by spontaneous VWF-platelet interactions: von Willebrand disease (VWD) type 2B and thrombotic thrombocytopenic purpura (TTP). For VWD type 2B, levels of activated VWF were increased 12-fold (P < .001) compared to levels in healthy volunteers. An inverse correlation between activated VWF levels and platelet count was observed (R2 = 0.74; P < .003). With regard to TTP, a 2-fold (P < .001) increase in activated VWF levels was found in plasma of patients with acquired TTP, whereas an 8-fold increase (P < .003) was found in congenital TTP. No overlap in levels of activated VWF could be detected between acquired and congenital TTP, suggesting that AU/VWFa-11 could be used to distinguish between both disorders. Furthermore, it could provide a tool to investigate the role of VWF in the development of thrombocytopenia in various diseases.
Environmental Inequity: Economic Causes, Economic Solutions (1997)

Eliminating "environmental racism" has become one of the premier civil rights and environmental issues of the 1990s. Relying on a handful of studies that purport to show patterns of discrimination against minorities and the poor in the siting of industrial activity, federal and state policymakers have attempted to limit further industrial siting in these areas. These "environmental justice" initiatives appear to be premature, however, in light of the substantial problems in current data documenting the prevalence of discrimination. The article examines one such shortcoming: namely, that existing research fails to account for the dynamic nature of the housing market. Analyzing data from the St. Louis metropolitan area, this study finds that economic factors-not siting discrimination--are behind many claims of environmental racism. This phenomenon suggests the need to develop public policies that fit the economic nature of the problem. In particular, a policy that compensates individuals living near industrial sites is the key to securing environmental justice
Single‐Crystal Rare‐Earth‐Doped Yttrium Orthosilicate Phosphors (1988)

This is a study of a group of Czochralski grown rare‐earth‐doped single‐crystal cathodoluminescent phosphors. Such dopants as Ce3+, Tb3+, Eu3+, Sm3+, Tm3+, Gd3+, and some of their combinations were investigated. Activation by, , and by produced the most efficient blue, green, and red phosphors, respectively. In comparison with our previous best garnet single‐crystal phosphor system, the blue, green, and red phosphors are by factors 12.7, 1.23, and 0.7 brighter, respectively. was shown to be an efficient single line (313 nm) emitting phosphor of very high spectral brightness in UV.
17β-Estradiol inhibits proliferation and migration of human vascular smooth muscle cells: similar effects in cells from postmenopausal females and in males (1996)

Objectives: Cardiovascular disease is rare in premenopausal women, but increases after the menopause when hormone replacement therapy reduces coronary events.Vascular smooth muscle cell @MC) proliferation and migration occur in atherosclerosis, restenosis and venous graft disease.We studied the effects of 17@estradiol on SMC proliferation and migration.Methods: SMC were cultured from saphenous veins of postmenopausal women and age-matched men.Cell growth was determined by 'H-thymidine incorporation and cell counting.Migration of SMC was assessed in 4-well chambers.SMC were seeded in one comer and PDGF-BB in filter paper glued onto the opposite wall.Results: PDGF-BB (5 rig/ml for 24 h) similarly stimulated 'H-thymidine incorporation in female (5 11 f 57%; n = 8) and male (528 f 62%; R-12) SMC.This was reduced by 17pestradiol (1O-s-1O-6 M, female 313 f 52%; male 337 f 54%; P < 0.05).PDGF-BB increased the number of SMC (P < 0.0001 at 10 days) obtained from females (153 f 3%; n -5) and males (150 f 4%; n = 51, which was inhibited by 17&estradiol (10m6 M, female 134 * 7%; male 128 f 5%; P < 0.05).Similar results were obtained with basic fibroblast growth factor.In contrast to 17P-estradiol, another steroid (dexamethasone) had no effects on 3H-thymidine incorporation in these cells stimulated with PDGF-BB.PDGF-BB (0.01-l ng> stimulated SMC migration (P < 0.05) which was inhibited by 17p-estradiol (10-'"-10-6 M; n -5; P < 0.005).Conclusion: 17@-Estradiol inhibits growth-factor-induced SMC proliferation and migration regardless of gender.These effects of 17@estradiol may contribute to its cardiovascular protective properties in postmenopausal women during replacement therapy.
Fabrication of PLGA-Collagen Hybrid Sponge (1999)

Abstract A hybrid sponge of biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) and collagen was fabricated by forming microsponges of collagen in the pores of PLGA sponge. Observation of the hybrid sponge by scanning electron microscopy (SEM) showed that microsponges of collagen with interconnected pore structures were formed. The hybrid structure was further confirmed by detecting elemental nitrogen using scanning electron microscopy-electron probe microanalysis (SEM-EPMA). Elemental nitrogen was detected in the microsponges of collagen and on the pore surfaces of PLGA, but not in the cross-sections of PLGA regions. These results indicate that microsponges of collagen were formed in the pores of the PLGA sponge and that the pore surfaces were also coated with collagen.
Physical Properties of Drilling Fluids at High Temperatures and Pressures (1989)

Summary Rheological and dynamic filtration properties are presented for water- and oil-based drilling fluids. The physical properties were obtained by use of the DYNAMIC HPHT® test system at test temperatures to 400°F [478 K], system pressures to 15,000 psi [103 MPa], and differential pressures to 600 psi [4.1 MPa]. The data indicated that the de Guzman-Andrade law can be used to describe the temperature effects on the viscosity of oil muds. We also observed that dynamic filtration rates of drilling fluids are greatly affected by solids plugging the pore space in the formation. Temperature and pressure affect dynamic, filtration by changing the dispersion of the solids in the fluid.
Interleukin-10 and its receptor. (1994)

The cytokine interleukin-10 (IL-10) has several important activities on cells of the immune system. IL-10 profoundly suppresses activation of macrophages, inhibiting their ability to secrete cytokines and serve as accessory cells for stimulation of T cell and natural killer (NK) cell function. IL-10 also plays a role in stimulating proliferation and differentiation of B cells, mast cells, and both mature and immature T cells. At least two herpesviruses harbor analogs of the IL-10 gene; the Epstein-Barr virus (EBV) homolog (BCRF1, viral IL-10, vIL-10) shares several of the cellular cytokine's activities, one or all of which may be important in the host-virus relationship. This article reviews recent studies on the function of IL-10 and discusses the initial characterization of its receptor.
O-Band III–V-on-Amorphous-Silicon Lasers Integrated With a Surface Grating Coupler (2016)

In this letter, we report on the design, fabrication, and performance of a hetero-integrated III-V/silicon distributed-feedback (DFB) laser in the O-band, with improved integration compatibility with the existing silicon photonics platforms. This structure uses amorphous silicon deposited at a low temperature (350 °C) to efficiently couple light from the III-V region into a thin silicon-on-insulator waveguide, without disrupting other existing silicon components. Continuous-wave regime is achieved at 25 °C, while lasing threshold and maximum output power in the waveguides are 50 mA and 33.6 mW, respectively. The maximum power coupled into a single-mode fiber at one end of the DFB is up to 4.7 mW.
Determination of (R,R)-glycopyrronium bromide and its related impurities by ion-pair HPLC. (2007)

A simple, rapid and specific ion-pair HPLC method for the determination of (R,R)-glycopyrronium bromide and its related impurities is presented, and parameters affecting the chromatographic properties of these compounds are discussed. Optimal analyte separation was achieved on base deactivated Nucleosil at 40 degrees C, using phosphate buffer pH 2.30 with sodium-1-decanesulfonate (0.01 M)/methanol (35/65; v/v) as eluent for isocratic elution at a flow rate 1 ml x min(-1). The analytical assay was validated according to international guidelines. The methodis suitable for in-process control and as stability indicating assay.
Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage (2005)

Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has been suggested to modulate p53-dependent functions including DNA damage-induced cell death. In this report, we used EX-527, a novel, potent, and specific small-molecule inhibitor of SIRT1 catalytic activity to examine the role of SIRT1 in p53 acetylation and cell survival after DNA damage. Treatment with EX-527 dramatically increased acetylation at lysine 382 of p53 after different types of DNA damage in primary human mammary epithelial cells and several cell lines. Significantly, inhibition of SIRT1 catalytic activity by EX-527 had no effect on cell growth, viability, or p53-controlled gene expression in cells treated with etoposide. Acetyl-p53 was also increased by the histone deacetylase (HDAC) class I/II inhibitor trichostatin A (TSA). EX-527 and TSA acted synergistically to increase acetyl-p53 levels, confirming that p53 acetylation is regulated by both SIRT1 and HDACs. While TSA alone reduced cell survival after DNA damage, the combination of EX-527 and TSA had no further effect on cell viability and growth. These results show that, although SIRT1 deacetylates p53, this does not play a role in cell survival following DNA damage in certain cell lines and primary human mammary epithelial cells.
Serial infusions of low-dose ketamine for major depression (2013)

Ketamine infusions at a lower rate than previously reported have demonstrated similar efficacy and excellent tolerability and may be more practically available for routine clinical care. Serial ketamine infusions appear to be more effective than a single infusion. Further research to test relapse prevention strategies with continuation ketamine infusions is indicated.
The Evaluation of Effects of Demographic Features, Biochemical Parameters, and Cytokines on Clinical Outcomes in Patients with Acute Renal Failure (2007)

We realized that in totally demographic features (male gender, advanced age, poor nutritional status), biochemical parameters (TC, albumin, and hemoglobin) and cytokine levels (IL-2R, IL-6, TNF-alpha), CRP and ESR may be predictive factors for mortality in patients with ARF.
Expression of Thrombospondin-1 in Cancer: A Role in Tumor Progression (1996)

Thrombospondin-1 (TSP-1), a trimeric high molecular weight glycoprotein, is one of the major secreted proteins of human platelets and an extracellular matrix component of a variety of cells including vascular endothelial cells and tumor cells. TSP-1 has been shown to be highly expressed in human malignant tissues and present in higher than normal levels in the plasma of cancer patients. TSP-1 has also been shown to promote hematogenous tumor spread, tumor cell adhesion and invasion, and angiogenesis. Overall these studies provide compelling evidence for the conclusion that TSP-1 plays an important role in tumor progression.
Surface Adsorption of the Urinary Marijuana Carboxy Metabolite: The Problem and a Partial Solution (1992)

Journal Article Surface Adsorption of the Urinary Marijuana Carboxy Metabolite: The Problem and a Partial Solution Get access William A. Joern William A. Joern St. Anthony's Med. Ctr., 10010 Kennerly Road, St. Louis, MO 63128 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Analytical Toxicology, Volume 16, Issue 6, November-December 1992, Page 401, https://doi.org/10.1093/jat/16.6.401 Published: 01 November 1992
China Cues for Smart Shoppers (1960)

China tableware of good quality is perhaps one of the most prized possessions a homemaker can have. And selecting a life~time pattern often confronts the college woman planning for marriage or career.
Vertical guided bonegraft augmentation in a new canine mandibular model (1996)

Using the mandibular inferior border of four fox hounds from an extraoral approach, six high-profile Brånemark implants were placed in each animal and bone grafted. Graft materials studied included demineralized freeze-dried allograft with and without irradiation sterilization (3.8 x 10(4) Gy), corticocancellous iliac autograft, blood clot, and a control. Corticocancellous grafts were studied with and without expanded polytetrafluoroethylene (EPTFE) barriers. The barrier function improved both graft volume incorporated and bone-implant interface contact. The autograft performed better than the allograft. Irradiation of the allograft did not appear to affect graft performance. The barrier functioned to improve graft incorporation for augmentation and interface contact and gives credence to the use of barriers in conjunction with vertical augmentation grafting of jawbone.
Computation of Aortic Pulse Wave Velocity and Aortic Extensibility from Pressure Gradient Measurements (1975)

This study is concerned with the computation of aortic pulse wave velocity based on simultaneous recordings of the aortic pressure gradient and first-time derivative of aortic pressure. These variables were recorded by means of a double-lumen catheter introduced in the aorta of four anesthetized closed chest dogs, and connected to critically damped manometer systems. Results of aortic pulse wave velocity were then compared: (i) to the true phase velocity obtained from spectra of apparent phase velocity, and (ii) to the pulse wave velocity computed from the time shift between maximum slopes of the pressure wave. From the aortic valves to 37 cm down the aortic trunk, pulse wave velocity increased from 410-460 cm/s to approximately 600-800 cm/s. Based on the wave propagation equation presented of Bramwell and Hill (Bramwell, J.C., and Hill, A. V. 1922. Proc. R. Soc. 93, 298-306), volumetric extensibility coefficients were computed from pulse wave velocity data. Results indicated that, from the aortic valves to 37 cm down to the aorta, the mean volumetric extensibility decreased from 0.43-0.56% deltaV/cm H2O to 0.16-0.25% deltaV/cm H2O (1 cm H2O = 94.1 N/m2).
Hierarchical context-aware hand detection algorithm for naturalistic driving (2016)

Hand activity is a critical monitoring component in understanding a driver's behavior within the car. Current vision-based hand detection algorithms perform poorly in naturalistic settings, due to various challenges such as global illumination changes and constant hand deformation and occlusion. To achieve a more accurate and robust hand detection system, this paper presents a hierarchical context-aware hand detection algorithm, which explicitly explores context cues in the vehicle such as prevalent hand shapes and locations, preferred driving habit and coupling effect between multiple hands. The proposed context-aware hand detection algorithm significantly outperforms the state-of-the-art on the VIVA hand dataset.
Molecular cloning and functional expression of bovine spleen ecto-NAD+ glycohydrolase: structural identity with human CD38 (1999)

Bovine spleen ecto-NAD(+) glycohydrolase, an archetypal member of the mammalian membrane-associated NAD(P)(+) glycohydrolase enzyme family (EC 3.2.2.6), displays catalytic features similar to those of CD38, i.e. a protein originally described as a lymphocyte differentiation marker involved in the metabolism of cyclic ADP-ribose and signal transduction. Using amino acid sequence information obtained from NAD(+) glycohydrolase and from a truncated and hydrosoluble form of the enzyme (hNADase) purified to homogeneity, a full-length cDNA clone was obtained. The deduced sequence indicates a protein of 278 residues with a molecular mass of 31.5 kDa. It predicts that bovine ecto-NAD(+) glycohydrolase is a type II transmembrane protein, with a very short intracellular tail. The bulk of the enzyme, which is extracellular and contains two potential N-glycosylation sites, yields the fully catalytically active hNADase which is truncated by 71 residues. Transfection of HeLa cells with the full-length cDNA resulted in the expression of the expected NAD(+) glycohydrolase, ADP-ribosyl cyclase and GDP-ribosyl cyclase activities at the surface of the cells. The bovine enzyme, which is the first 'classical' NAD(P)(+) glycohydrolase whose structure has been established, presents a particularly high sequence identity with CD38, including the presence of 10 strictly conserved cysteine residues in the ectodomain and putative catalytic residues. However, it lacks two otherwise conserved cysteine residues near its C-terminus. Thus hNADase, the truncated protein of 207 amino acids, represents the smallest functional domain endowed with all the catalytic activities of CD38/NAD(+) glycohydrolases so far identified. Altogether, our data strongly suggest that the cloned bovine spleen ecto-NAD(+) glycohydrolase is the bovine equivalent of CD38.
Perspectives on new waveform design for 5G small cell (2014)

Mobile Internet and Internet of Thing (IoT) have been widely recognized as the two major driven forces of next generation mobile systems (IMT-2020 or 5G). Key performance indicators (KPI) of 5G are identified to satisfy the needs of these applications. It is analyzed that a new waveform design with large bandwidth at high frequency for small cell is expected for some critical KPIs. In this paper, perspectives on new waveform design for 5G small cell are presented. Specifically, the design principles for transmission time interval (TTI), system bandwidth, the subcarrier spacing, the cyclic prefix (CP), guard period (GP) and frame structure are discussed. The feasible range of numerology of the new waveform considering efficiency, flexibility and backward compatibility jointly is derived. Finally, an exemplary numerology for 5G small cell is given.
Hypothesis for Improving Accessory Filtration by Using Geometry (1994)

Doheny Eye Institute, Departments of Physiology and Biophysics *Ophthalmology, University of Southern California, Los Angeles, California, U.S.A.
Chronic motor cortex stimulation in the treatment of central and neuropathic pain. Correlations between clinical, electrophysiological and anatomical data (1999)

Thirty-two patients with refractory central and neuropathic pain of peripheral origin were treated by chronic stimulation of the motor cortex between May 1993 and January 1997. The mean follow-up was 27.3 months. The first 24 patients were operated according to the technique described by Tsubokawa. The last 13 cases (eight new patients and five reinterventions) were operated by a technique including localisation by superficial CT reconstruction of the central region and neuronavigator guidance. The position of the central sulcus was confirmed by the use of intraoperative somatosensory evoked potentials. The somatotopic organisation of the motor cortex was established peroperatively by studying the motor responses at stimulation of the motor cortex through the dura. Ten of the 13 patients with central pain (77%) and ten of the 12 patients with neuropathic facial pain had experienced substantial pain relief (75%). One of the three patients with post-paraplegia pain was clearly improved. A satisfactory result was obtained in one patient with pain related to plexus avulsion and in one patient with pain related to intercostal herpes zooster. None of the patients developed epileptic seizures. The position of the stimulating poles effective on pain corresponded to the somatotopic representation of the motor cortex. The neuronavigator localisation and guidance technique proved to be most useful identifying the appropriate portion of the motor gyrus. It also allowed the establishment of reliable correlations between electrophysiological-clinical and anatomical data which may be used to improve the clinical results and possibly to extend the indications of this technique.
Use of A Taxonomy of Security Faults (1996)

Security in computer systems is important soasto ensure reliable operation and to protect the integrity of stored information. Faults in the implementation of critical components can be exploited to breach security and penetrate a system. These faults must be identified, detected, and corrected to ensure reliability and safeguard against denial of service, unauthorized modification of data, or disclosure of information. We define a classification of security faults in the Unix operating system. We state the criteria used to categorize the faults and present examples of the different fault types. We present the design and implementation details of a prototype database to store vulnerability information collected from different sources. The data is organized according to our fault categories. The information in the database can be applied in static audit analysis of systems, intrusion detection, and fault detection. We also identify and describe software testing methods that should be effective in detecting di erent faults in our classification scheme.
A series-shunt symmetric switch makes transmit-receive antennas reconfigurable in multipath channels (2011)

This paper presents a new series-shunt symmetry switch integrated in a 0.12-um triple-well CMOS technology up to 35 GHz makes transmit-receive (T/R) antennas reconfigurable in wireless multipath channels. This switch design employs series-shunt architecture to accommodate the design challenge of low insertion loss (IL) and high isolation (ISO) performance. It exhibits lower than 1-dB insertion loss, higher than 40-dB isolation. 21-dBm input power at 1-dB compression point (P1dB) is achieved without using additional techniques to improve the linearity.
AlN Contour-Mode Vibrating RF MEMS for Next Generation Wireless Communications (2006)

AlN contour-mode vibrating RF MEMS resonator technology is described as capable of low-loss filtering and frequency synthesis for next generation wireless devices. Contour-mode piezoelectric resonators can span frequencies from 10 MHz up to few GHz on the same silicon chip offering high quality factors in air (1,000-4,000) and low motional resistance (25-700 Omega). Low loss (<- 1.5 dB) electrically and mechanically coupled filters and low phase noise oscillators can be easily implemented using this resonator technology. Low power transceiver architectures based on frequency hopping, multi-band filtering and direct frequency synthesis are presented as next generation wireless solutions that will be enabled by this new class of AIN contour-mode resonators