gebhart/patrepeval huggingface dataset:
Statistical thermodynamics of fluid mixtures (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStatistical thermodynamics of fluid mixturesRobert H. Lacombe and Isaac C. SanchezCite this: J. Phys. Chem. 1976, 80, 23, 2568–2580Publication Date (Print):November 1, 1976Publication History Published online1 May 2002Published inissue 1 November 1976https://pubs.acs.org/doi/10.1021/j100564a009https://doi.org/10.1021/j100564a009research-articleACS PublicationsRequest reuse permissionsArticle Views2059Altmetric-Citations496LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cementless Hemispheric Porous-Coated Sockets Implanted with Press-Fit Technique without Screws (2002)

The fixation of this press-fit socket did not deteriorate over time and was associated with a low rate of osteolysis. The most common reasons for reoperation were wear and dissociation of the polyethylene insert.
Depletion of CD25<sup>+</sup>CD4<sup>+</sup>T cells (Tregs) enhances the HBV-specific CD8<sup>+</sup>T cell response primed by DNA immunization (2005)

CD25(+) Treg cells suppress priming and/or expansion of antigen-specific CD8(+) T cells during DNA immunization and the peak CD8(+) T cell response is enhanced by depleting this cell population. Furthermore, Treg cells appear to be involved in the contraction phase of the CD8(+) T cell response and may affect the quality of memory T cell pools. The elimination of Treg cells or their inhibition may be important in immunotherapeutic strategies to control HBV infection by inducing virus-specific cytotoxic T lymphocyte responses in chronically infected subjects.
Taser Blunt Probe Dart-To-Heart Distance Causing Ventricular Fibrillation in Pigs (2008)

The maximum distance between the heart and a model Taser stimulation dart, called the dart-to-heart distance, at which the Taser can directly cause ventricular fibrillation (VF), was measured in pigs. A 9-mm-long blunt probe was advanced snugly through the surrounding tissues toward the heart. Five animals [pig mass=61.2+/-6.23 standard deviation (SD) kg] for ten dart-to-heart distances where the Taser caused VF were tested. The dart-to-heart distances where the Taser caused VF of the first stimulation site ranged from 4 to 8 mm with average 6.2 mm+/-1.79 (SD) and of the second stimulation site ranged from 2 to 8 mm with average 5.4 mm+/-2.41 (SD). The results help inform the evolving discussion of risks associated with Tasers.
Analysis of methane biodegradation by Methylosinus trichosporium OB3b. (2009)

The microbial oxidation of methane in the atmosphere is performed by methanotrophic bacteria that use methane as a unique source of carbon and energy. The objective of this work consisted of the investigation of the best conditions of methane biodegradation by methanotrophic bacteria Methylosinus trichosporium OB3b that oxidize it to carbon dioxide, and the use of these microorganisms in monitoring methods for methane. The results showed that M. trichosporium OB3b was capable to degrade methane in a more effective way with an initial microorganism concentration of 0.0700 g.L(-1), temperature of 30ºC, pH 6.5 and using 1.79 mmol of methane. In these same conditions, there was no bacterial growth when 2.69 mmol of methane was used. The specific rate of microorganism growth, the conversion factor, the efficiency and the volumetric productivity, for the optimized conditions of biodegradation were, respectively, 0.0324 h(-1), 0.6830 gcells/gCH4, 73.73% and 2.7732.10(-3) gcells/L.h. The final product of methane microbiological degradation, carbon dioxide, was quantified through the use of a commercial electrode, and, through this, the grade of methane conversion in carbon dioxide was calculated.
A new and efficient total synthesis of streptonigrin (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new and efficient total synthesis of streptonigrinAndrew S. Kende, Dennis P. Lorah, and Rodney J. BoatmanCite this: J. Am. Chem. Soc. 1981, 103, 5, 1271–1273Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/ja00395a071https://doi.org/10.1021/ja00395a071research-articleACS PublicationsRequest reuse permissionsArticle Views558Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Photooxygenation (singlet oxygen) of tetrathioethylenes (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotooxygenation (singlet oxygen) of tetrathioethylenesWaldemar Adam and Ju-Chao LiuCite this: J. Am. Chem. Soc. 1972, 94, 4, 1206–1209Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://pubs.acs.org/doi/10.1021/ja00759a029https://doi.org/10.1021/ja00759a029research-articleACS PublicationsRequest reuse permissionsArticle Views187Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists (1989)

To investigate the preferred spatial relationship of the distal phosphonic acid to the alpha-amino acid group of the established competitive N-methyl-D-aspartic acid (NMDA) antagonists APH (1) and APV (2), we have prepared a series of ortho-, meta-, and para-substituted (phosphonoalkyl)phenylglycine and -phenylalanine derivatives. With use of a [3H]CPP receptor binding assay, significant binding activity was observed to be critically dependent on both the position of substitution and length of alkyl spacing groups. Two compounds, 4-(phosphonomethyl)-phenylglycine (6, PD 129635) and 3-(phosphonomethyl)phenylalanine (15, PD 130527), displayed receptor-binding affinity comparable to that of APH. Like APH, these compounds were also effective in antagonizing both the proconvulsant and lethal action of NMDA-administered retrobulbar in the mouse. Data are also provided which compare directly the binding efficacy of these compounds against that disclosed recently for the related NMDA antagonist 18 (NPC 451). A preliminary comparison of the structures showing good receptor-binding affinity and in vivo antagonist activity suggests that the NMDA receptor prefers a "folded" rather than "extended" conformation.
4-Substituted 4-Hydroxycyclohexa-2,5-dien-1-ones with Selective Activities against Colon and Renal Cancer Cell Lines (2003)

The synthesis and antitumor evaluation of a series of new heteroaromatic- and aromatic-substituted hydroxycyclohexadienones ("quinols"), and their imine counterparts, are described. The quinols were synthesized via the addition of a lithiated aromatic moiety to a quinone ketal followed by deprotection. When the aromatic portion of the molecule is a fused heterobicyclic structure (e.g., benzothiazole derivative 7a), potent in vitro antitumor activity was observed in HCT 116 (GI50 = 40 nM) and HT 29 (GI50 = 380 nM) human colon as well in as MCF-7 and MDA 468 human breast cancer cell lines. When examined on the NCI Developmental Therapeutics Screening Program in vitro screen (60 human cancer cell lines), active compounds in this series consistently displayed a highly unusual pattern of selectivity; cytotoxicity (LC50) was concentrated in certain colon and renal cell lines only. Analogue 7a also showed in vivo antitumor activity against human RXF 944XL renal xenografts in nude NMRI mice and is the focus of further study.
From pathogen to medicine: HIV-1-derived lentiviral vectors as vehicles for dendritic cell based cancer immunotherapy (2005)

Over the years, the unique capacity of dendritic cells (DC) for efficient activation of naive T cells has led to their extensive use in cancer immunotherapy protocols. In order to be able to fulfil their role as antigen-presenting cells, the antigen of interest needs to be efficiently introduced and subsequently correctly processed and presented by the DC. For this purpose, a variety of both viral and non-viral antigen-delivery systems have been evaluated. Amongst those, HIV-1-derived lentiviral vectors have been used successfully to transduce DC. This review considers the use of HIV-1-derived lentiviral vectors to transduce human and murine DC for cancer immunotherapy. Lentivirally transduced DC have been shown to present antigenic peptides, prime transgene-specific T cells in vitro and elicit a protective cytotoxic T-lymphocyte (CTL) response in animal models. Different parameters determining the efficacy of transduction are considered. The influence of lentiviral transduction on the DC phenotype and function is described and the induction of immune responses by lentivirally transduced DC in vitro and in vivo is discussed in detail. In addition, direct in vivo administration of lentiviral vectors aiming at the induction of antigen-specific immunity is reviewed. This strategy might overcome the need for ex vivo generation and antigen loading of DC. Finally, future perspectives towards the use of lentiviral vectors in cancer immunotherapy are presented.
Preparation of a 24-Nor-1,4-dien-3-one Triterpene Derivative from Betulin:  A New Route to 24-Nortriterpene Analogues<sup>1</sup> (2002)

A new route to 24-nortriterpene derivatives with 2-hydroxy-Delta(1,4)-cyclohexadien-3-one A-rings from triterpene precursors has been demonstrated beginning with betulin to prepare derivatives of betulinic acid. The key steps in the transformation are a Suárez cleavage of the A-ring with a subsequent SmI(2)-mediated pinacol-type coupling to reclose the A-ring following removal of the C-24 carbon by oxidative cleavage.
Copper‐dependent reciprocal transcriptional regulation of methane monooxygenase genes in <i>Methylococcus capsulatus</i> and <i>Methylosinus trichosporium</i> (1997)

The methanotrophic bacteria Methylococcus capsulatus (Bath) and Methylosinus trichosporium OB3b convert methane to methanol using the enzyme, methane monooxygenase (MMO). These bacteria are able to express two distinct MMOs: a cytoplasmic or soluble form (sMMO) and a membrane-bound or particulate form (pMMO). Differential expression of sMMO and pMMO is regulated by the amount of copper ions available to the cells; sMMO is expressed at low copper-biomass ratios, whereas pMMO is expressed at high copper-biomass ratios. In both methanotrophs, transcription of the sMMO gene cluster is negatively regulated by copper ions. Data suggest that transcription of the M. trichosporium OB3b sMMO gene cluster is directed from a sigma54-like and a sigma70-like promoter. The pMMO (pmo) genes of M. capsulatus (Bath) are transcribed into a polycistronic mRNA of 3.3 kb. The synthesis of this mRNA was activated by copper ions. Activation of pmo transcription by copper ions was concomitant with repression of sMMO gene transcription in both methanotrophs. This suggests that a common regulatory pathway may be involved in the transcriptional switch between sMMO and pMMO gene expression.
Ecological impacts of flood mitigation and drainage in coastal lowlands (1999)

The Australian government has been extremely successful in controlling excess water and promoting productivity and development in the coastal lowlands, which are subject to frequent flooding by mitigating flood impacts through drainage, stream redesign, levies and floodgates. The problem is that now almost all of Australia's coastal embayment and estuarine floodplains are underlain by brackish water sediments containing naturally-occurring iron sulfide minerals that forms a toxic brew harmful to both terrestrial and aquatic species.
Iron Nanoparticles Supported on Chemically‐Derived Graphene: Catalytic Hydrogenation with Magnetic Catalyst Separation (2011)

Abstract Iron nanoparticles (Fe‐NP) supported on chemically‐derived graphene (CDG) were prepared and identified as an effective catalyst for the hydrogenation of alkenes and alkynes. The catalyst can easily be separated by magnetic decantation.
Analysis by Electrophoretic Transfer Blotting of Japanese Cedar Pollen Allergens which React with IgG and IgE Antibodies in the Serum of Patients (1986)

Crude extract of Japanese cedar pollen was fractionated by DEAE-cellulose chromatography to separate the major allergenic components. In order to analyze which antigens react with IgG or IgE antibodies in the serum of Japanese cedar pollinosis patients, an electrophoretic transfer blotting was performed. Both IgE and IgG antibodies reacted with several common antigens, while IgG additionally reacted with some low-molecular-weight proteins.
Formal description of multi-word lexemes with the finite-state formalism IDAREX (1996)

Most multi-word lexemes (MWLs) allow certain types of variation. This has to be taken into account for their description and their recognition in texts. We suggest to describe their syntactic restrictions and their idiosyncratic peculiarities with local grammar rules, which at the same time allow to express in a general way regularities valid for a whole class of MWLs. The local grammars can be written in a very convenient and compact way as regular expressions in the formalism IDAREX which uses a two-level morphology. IDAREX allows to define various types of variables, and to mix canonical and inflected word forms in the regular expressions.
Stability of citral-containing and citralless lemon oils in flavor emulsions and beverages (1994)

The investigation was conducted to compare the stabilities of citral-containing and citralless lemon emulsions (EC and ECL) and beverages (BC and BCL) during storage at different temperatures by both gas chromatographic and sensory analyses
Accelerating spatially varying Gaussian filters (2010)

High-dimensional Gaussian filters, most notably the bilateral filter, are important tools for many computer graphics and vision tasks. In recent years, a number of techniques for accelerating their evaluation have been developed by exploiting the separability of these Gaussians. However, these techniques do not apply to the more general class of spatially varying Gaussian filters, as they cannot be expressed as convolutions. These filters are useful because the underlying data---e.g. images, range data, meshes or light fields---often exhibit strong local anisotropy and scale. We propose an acceleration method for approximating spatially varying Gaussian filters using a set of spatially invariant Gaussian filters each of which is applied to a segment of some non-disjoint partitioning of the dataset. We then demonstrate that the resulting ability to locally tilt, rotate or scale the kernel improves filtering performance in various applications over traditional spatially invariant Gaussian filters, without incurring a significant penalty in computational expense.
Algorithmic strategies for full waveform inversion: 1D experiments (2009)

Abstract Full-waveform seismic inversion, i.e., the iterative minimization of the misfit between observed seismic data and synthetic data obtained by a numerical solution of the wave equation provides a systematic, flexible, general mechanism for reconstructing earth models from observed ground motion. However, many difficulties arise for highly resolved models and the associated large-dimensional parameter spaces and high-frequency sources. First, the least-squares data-misfit functional suffers from spurious local minima, which necessitates an accurate initial guess for the smooth background model. Second, total variation regularization methods that are used to resolve sharp interfaces create significant numerical difficulties because of their nonlinearity and near-degeneracy. Third, bound constraints on continuous model parameters present considerable difficulty for commonly used active-set or interior-point methods for inequality constraints because of the infinite-dimensional nature of the parameters. Finally, common gradient-based optimization methods have difficulties scaling to the many model parameters that result when the continuous parameter fields are discretized. We have developed an optimization strategy that incorporates several techniques address these four difficulties, including grid, frequency, and time-window continuation; primal-dual methods for treating bound inequality constraints and total variation regularization; and inexact matrix-free Newton-Krylov optimization. Using this approach, several computations were performed effectively for a 1D setting with synthetic observations.
Preliminary Results of M-VAC (Methotrexate, Vinblastine, Doxorubicin and Cisplatin) for Transitional Cell Carcinoma of the Urothelium (1985)

The M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) regimen was used to treat 25 patients with transitional cell carcinoma of the urothelial tract. Treatment consisted of monthly cycles of 30 mg. per m.2 methotrexate, followed 24 hours later by 3 mg. per m.2 vinblastine, 30 mg. per m.2 doxorubicin and 70 mg. per m.2 cisplatin, and concluded with repeat vinblastine and methotrexate on days 15 and 22. Significant tumor regression was noted in 71 per cent of the patients. Complete clinical remission was observed in 12 of 24 patients (50 per cent, 95 per cent confidence limits 30 to 70 per cent) with bidimensionally measurable indicator lesions, 6 of whom had pathological confirmation. After surgical exploration 4 patients required downstaging to a partial remission. The median duration of response has not yet been reached at 9.5 plus months, range 4.5 plus to 16 plus. Five patients (21 per cent) had a partial clinical remission for 4 to 8 plus months, 1 had a minor response for 4 months and 1 had stable disease for 11 months. All metastatic sites responded, including bone (6 of 8 cases), liver (3 of 5), locoregional (12 of 17) and intravesical (6 of 7) disease. Toxicity included moderately severe myelosuppression that resulted in nadir sepsis in 4 patients and a drug-related death in 1, mild to moderate anorexia, vomiting, alopecia and renal dysfunction. These preliminary results suggest that treatment with methotrexate, vinblastine, doxorubicin and cisplatin is extremely effective against locoregional and disseminated urothelial tract tumors, with the expectation (95 per cent confidence limits) of inducing objective tumor regression in 53 to 89 per cent of the cases.
Amylase, lipase, pancreatic isoamylase, and phospholipase A in diagnosis of acute pancreatitis (1995)

To determine the utility of serum amylase (AMY), lipase (Lp), pancreatic isoamylase (isoA), phospholipase A (PLA), and urine AMY in the diagnosis of acute pancreatitis, samples of serum and urine were obtained on admission and every day thereafter for 5 days from 384 patients with acute abdominal pain. Diagnostic accuracy, determined as the area under the receiver operating characteristic curve, was > 0.975 for serum AMY, Lp, isoA, and urine AMY. For each of these enzymes, a threshold value (twice to sixfold the upper limit of the reference values) offering diagnostic efficiency > 95% could be determined. In contrast, accuracy and efficiency of serum PLA were low. The profiles of these enzymes in acute pancreatitis decreased in a parallel fashion over 5 days except for PLA. We conclude that diagnostic utilities are similar for serum AMY, Lp, isoA, and urine AMY for acute pancreatitis, provided that an appropriate threshold is established.
Nucleoside diphosphate kinase from Escherichia coli (1995)

Nucleoside diphosphate (NDP) kinase from Escherichia coli was purified to homogeneity and was crystallized. Gel filtration analysis of the purified enzyme indicated that it forms a tetramer. The enzyme was phosphorylated with [gamma-32P]ATP, and the pH stability profile of the phosphoenzyme indicated that two different amino acid residues were phosphorylated. Both a histidine residue and serine residues, including Ser-119 and Ser-121, appear to be phosphorylated. A Ser119Ala/Ser121Ala double mutant (i.e., with a Ser-to-Ala double mutation at positions 119 and 121), as well as Ser119Ala and Ser121Ala mutants, was isolated. All of these retained NDP kinase activity; also, both the Ser119Ala and Ser121Ala mutants could still be autophosphorylated. In the case of the double mutant, a slight autophosphorylation activity, which was resistant to acid treatment, was still detected, indicating that an additional minor autophosphorylation site besides His-117 exists. These results are discussed in light of the recent report of N. J. MacDonald et al. on the autophosphorylation of human NDP kinase (J. Biol. Chem. 268:25780-25789, 1993).
The Implantable Neurocybernetic Prosthesis System (1991)

The neurocybernetic prosthesis system (NCP) is an implantable, multiprogrammable pulse generator that delivers constant current electrical signals to the vagus nerve for the purpose of reducing the frequency and severity of epileptic seizures. The signals are delivered on a predetermined schedule, or may be initiated by the patient with an external magnet. The device is implanted in a subcutaneous pocket in the chest just below the clavicle, similar to pacemaker placement. The stimulation signal is transmitted from the prosthesis to the vagus nerve through a lead connected to an electrode which is a multi-turn silicone helix, with a platinum band on the inner turn of one helix. The prosthesis can be programmed with any IBM- compatible personal computer using NCP software and a programming wand.