gebhart/patrepeval huggingface dataset:
Speculative Dynamics (1991)

This paper presents evidence on the characteristic speculative dynamics of returns on stocks, bond, foreign exchange, real estate, collectibles, and precious metals. It highlights four stylized facts. First, returns tend to be positively serially correlated at high frequency. Second, they are weakly negatively serially correlated over long horizons. Third, deviations of asset values from proxies for fundamental value have predictive power for returns. Fourth, short term interest rates are negatively correlated with excess returns on other assets. The similarity of the results across markets suggests that they may be due to inherent features of the speculative process.
Transmission Estimation in Underwater Single Images (2013)

This paper proposes a methodology to estimate the transmission in underwater environments which consists on an adaptation of the Dark Channel Prior (DCP), a statistical prior based on properties of images obtained in outdoor natural scenes. Our methodology, called Underwater DCP (UDCP), basically considers that the blue and green color channels are the underwater visual information source, which enables a significant improvement over existing methods based in DCP. This is shown through a comparative study with state of the art techniques, we present a detailed analysis of our technique which shows its applicability and limitations in images acquired from real and simulated scenes.
Multipurpose Internet Mail Extensions (MIME) Part Two: Media Types (1996)

This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements.Please refer to the current edition of the "Internet Official Protocol Standards" (STD 1) for
Human tumors studied with genetic markers. (1976)

Genetic marker systems have been employed to investigate the origin and development of many human tumors. The type of information already gained with such systems includes the probable single cell origin of chronic myelocytic leukemia in a marrow stem cell. The G-6-PD system has also confirmed the hypothesis that at least some hereditary and viral tumors have multiple cell origin. However, Burkitt lymphoma, the malignancy in man for which there is a great amount of circumstantial evidence for a viral cancer, has a clonal origin. Of particular interest is the demonstration that early relapses after remissions of Burkitt lymphoma represent reemergence of the original malignant cell lines, whereas some late recurrences may be the result of newly induced malignant clones. Similarly, some recurrences of acute lymphoblastic leukemia in patients treated with marrow transplantation may be new occurrences of disease. These observations have important implications for the etiology and pathogenesis of Burkitt lymphoma and acute lymphoblastic leukemia.
Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors (2014)

A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based core. The pharmacophore corresponds to β-turns of the neurotrophin polypeptides neurotrophin-3 (NT-3), nerve growth factor (NGF), or brain-derived neurotrophic factor (BDNF). These are the natural ligands for TrkC, TrkA, and TrkB receptors, respectively. The linker length and the side-chain orientation of each monomer within the bivalent mimics were systematically altered, and the impact of these changes on the function of each ligand was evaluated. While the monovalent peptidomimetics had no detectable binding or bioactivity, four bivalent peptidomimetics (2c, 2d, 2e, 3f) are selective TrkC ligands with antagonistic activity, and two bivalent peptidomimetics (1a, 1b) are TrkC and TrkA ligands with antagonistic activity. All these bivalent compounds block ligand-dependent receptor activation and cell survival, without affecting neuritogenic differentiation. This work adds to our understanding of how the neurotrophins function through Trk receptors, and demonstrates that peptidomimetics can be designed to selectively disturb specific biological signals, and may be used as pharmacological probes or as therapeutic leads. The concept of altering side-chain, linker length, and sequence orientation of a subunit within a pharmacophore provides an easy modular approach to generate larger libraries with diversified bioactivity.
The formation and properties of subtilisn-modified glucoamylase. (1976)

The glucoamylase I which was purified from a culture of Aspergillus awamori var. kawachi as an enzyme having an ability to digest raw starch, was converted to a modified enzyme with decrease in molecular weight and carbohydrate content by incubation with subtilisin in 0.01M phosphate buffer, pH 6.8, at 30°C. The modified glucoamylase, isolated by the DEAE-Sephadex A-50 column chromatography, showed a 77% specific activity, and the same manner of the hydrolysis curve for gelatinized potato starch and maltose as the native enzyme, but showed no digestibility for raw starches nor adsorbability onto raw corn-starch, and a lower hydrolysis limit of 80 per cent for glycogen. Stabilities also decreased at pH 9 and at 65°C, respectively. Protease was proved to change the properties of glucoamylase.
Epitaxial semimetallic HfxZr1−xB2 templates for optoelectronic integration on silicon (2006)

High quality heteroepitaxial HfxZr1−xB2 (x=0–1) buffers were grown directly on Si(111). The compositional dependence of the film structure and ab initio elastic constants were used to show that hexagonal HfxZr1−xB2 possess tensile in-plane strain (0.5%) as grown. High quality HfB2 films were also grown on strain compensating ZrB2-buffered Si(111). Initial reflectivity measurements of thick ZrB2 films agree with first principles calculations which predict that the reflectivity of HfB2 increases by 20% relative to ZrB2 in the 2–8eV range. These tunable structural, thermoelastic, and optical properties suggest that HfxZr1−xB2 templates should be suitable for broad integration of III nitrides with Si.
Metal–semiconductor–metal near-infrared light detector based on epitaxial Ge/Si (1998)

In this letter we report on a metal–semiconductor–metal photodetector based on thick relaxed Ge layers, epitaxially grown on silicon after insertion of a low-temperature-grown Ge buffer layer. The detector shows a good responsivity at normal incidence at both 1.3 and 1.55 μm, with a maximum responsivity of 0.24 A/W at 1.3 μm under a 1 V bias. A response time of about 2 ns has been measured.
Technical note Design and architecture of a digital music library on the Web (2001)

Abstract In this paper, a Web-based digital music library based on a three-tier architecture is presented. The digital library's primary goal is to efficiently manage distributed mp3 file collections. The proposed methodology makes use of the metadata existing inside the ID3 tag of each mp3 file. Such information is extracted from the corresponding files and stored in separate, XML-based data structures, which are part of the overall distributed information retrieval module. The digital library's actual data is kept at the back-end in a distributed fashion. Communication between the layers of the digital library and the various architectural components that reside at the middle layer is facilitated through the employment of the XML standard.
Aberrant Expression of Oncogenic and Tumor-Suppressive MicroRNAs in Cervical Cancer Is Required for Cancer Cell Growth (2008)

MicroRNAs (miRNAs) play important roles in cancer development. By cloning and sequencing of a HPV16(+) CaSki cell small RNA library, we isolated 174 miRNAs (including the novel miR-193c) which could be grouped into 46 different miRNA species, with miR-21, miR-24, miR-27a, and miR-205 being most abundant. We chose for further study 10 miRNAs according to their cloning frequency and associated their levels in 10 cervical cancer- or cervical intraepithelial neoplasia-derived cell lines. No correlation was observed between their expression with the presence or absence of an integrated or episomal HPV genome. All cell lines examined contained no detectable miR-143 and miR-145. HPV-infected cell lines expressed a different set of miRNAs when grown in organotypic raft cultured as compared to monolayer cell culture, including expression of miR-143 and miR-145. This suggests a correlation between miRNA expression and tissue differentiation. Using miRNA array analyses for age-matched normal cervix and cervical cancer tissues, in combination with northern blot verification, we identified significantly deregulated miRNAs in cervical cancer tissues, with miR-126, miR-143, and miR-145 downregulation and miR-15b, miR-16, miR-146a, and miR-155 upregulation. Functional studies showed that both miR-143 and miR-145 are suppressive to cell growth. When introduced into cell lines, miR-146a was found to promote cell proliferation. Collectively, our data indicate that downregulation of miR-143 and miR-145 and upregulation of miR-146a play a role in cervical carcinogenesis.
Denmark (2012)

The Danish state administration is part of a large public sector that since a large-scale amalgamation reform in 2007 is organized in one state administration, five regions and 98 municipalities. Since the 1980s, almost one-third of the Danish workforce, measured as full-time employees, has been employed in the public sector, the majority providing welfare services in municipalities and regional healthcare. Approximately 15–20 per cent of full-time public positions are jobs defined as public administration as opposed to service production. Most of them are employed in the state administration (Hansen 2011b; Statistics-DK 2010).KeywordsLegal StatusAgency AutonomyMinisterial RuleState AdministrationAutonomy IndexThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Incidence of Age-Related Cataract (1998)

Incident cataracts are common age-related problems, and incidence increases with increasing age at baseline. These data will help in planning for future care (eg, cataract surgery and change in spectacle correction) and in investigating the importance of risk factors.
Flavone Limitations to Root Nodulation and Symbiotic Nitrogen Fixation in Alfalfa (1987)

Transcription of the nodABC genes in Rhizobium meliloti is required for root nodule formation in alfalfa (Medicago sativa L.) and occurs when specific compounds, such as the flavone luteolin, are supplied by the host plant. Results reported here indicate how luteolin in the root and rhizosphere can affect subsequent N(2) fixation and plant growth. Previous experiments with ;Hairy Peruvian 32' (HP32), an alfalfa population produced from ;Hairy Peruvian' (HP) by two generations of selection for increased N(2) fixation and growth, found that HP32 had more root nodules and fixed more N(2) than the parental HP population. In the present study, flavonoid extracts of HP32 seedling roots are shown to contain a 60% higher concentration of compounds that induce transcription of a nodABC-lacZ fusion in R. meliloti than comparable extracts of HP roots. Chromatographic data indicated that HP32 roots had a 77% higher concentration of luteolin than HP roots. Adding 10 micromolar luteolin to the rhizosphere of HP seedlings increased nodulation, N(2) fixation, total N, and total dry weight but had no effect on nitrate assimilation. These data show that normal levels of flavone nodulation signals in the rhizosphere of HP alfalfa can limit root nodulation, symbiotic N(2) fixation, and seedling growth and suggest that one mechanism for increasing N(2) fixation can be the genetic enhancement of specific biochemical signals which induce nodulation genes in Rhizobium.
Evaluation of a New Method of Ivor-Lewis Intraoperative Nutrient Tube Placement in Patients with Esophageal Cancer (2018)

Objective
To evaluate the clinical effects of a new method for the placement of feeding tubes in the treatment of esophageal cancer with Ivor-Lewis surgery.


Methods
A total of 117 cases with esophageal cancer in the same surgery group from January 2013 to December 2016 were collected from Department of Thoracic Surgery, Affiliated Hospital of Inner Mongolia Medical University. Before March 2015, 49 cases of enteral nutrition were treated with jejunostomy. After that date, 68 cases were treated with the new method of Nose-Duodenal feeding tube placement. Tube-placement time, tube-carrying comfort, the incidence of anastomotic leakage, pulmonary infection, and complications related to the nutrition tube were compared.


Results
Nutrition tube were successfully placed for 117 cases. One case with nose-duodenal feeding tube placement failed. There were no hospital deaths in the two groups. The duration of operation was significantly shorter in the nose-duodenal tube group than in the jejunostomy group [(6.2±1.8) min vs (18.2±8.2) min, P 0.05). No postoperative gastric emptying and acute gastric dilatation occurred. Two patients in the jejunostomy group had abdominal wall fistula leakage (1 case was eventually extirpated due to multiple exudates), and 2 patients had incomplete intestinal obstruction; One patient in the nose-duodenal tube group had irritability after surgery. One patient pulled out the stomach tube and duodenal nutrition tube due to anxiety.


Conclusions
In the treatment of esophageal cancer, the use of nose-duodenal nutrition tube placement method is simple, less traumatic, shorter, with fewer complications and good clinical results.


Key words: 
Ivor-Lewis; Enteral nutrition; Jejunostomy; Nose-duodenal
Anionic sites in the glomerular basement membrane. In vivo and in vitro localization to the laminae rarae by cationic probes. (1979)

Cationized ferritin (CF) of narrow pI range (7.3-7.5) and the basic dye ruthenium red (RR) have been used as cationic probes to partially characterize anionic sites previously demonstrated in the glomerular basement membrane (GBM). When CF was given i.v. to normal rats and the left kidney was fixed by perfusion 15 min thereafter, clusters of CF molecules were found throughout the lamina rara interna (LRI), lamina rara externa (LRE), and mesangial matrix distributed at regular (approximately 60 nm) intervals. When kidneys were perfused with aldehyde fixative containing RR, small (20 nm) RR-stained particles were seen in the same locations distributed with the same 60 nm repeating pattern, forming a quasiregular, lattice-like arrangement. Fine (approximately 3 nm) filaments connected the sites and extended between them and the membranes of adjoining endothelial and epithelial cells. When CF was given i.v. followed by perfusion with RR in situ, both probes localized to the same sites. CF remained firmly bound after prolonged perfusion with 0.1-0.2 M KCl or NaCl. It was displaced by perfusion with buffers of high ionic strength (0.4-0.5 M KCl) or pH (less than 3.0 or greater than 10.0). CF also bound (clustered at approximately 60 nm intervals) to isolated GBM's, and binding was lost when such isolated GBM's were treated with buffers of high ionic strength or pH. These experiments demonstrate the existence of a quasi-regular, lattice-like network of anionic sites in the LRI and LRE and the mesangial matrix. The sites are demonstrable in vivo (by CF binding), in fixed kidneys (by RR staining), and in isolated GBM's (by CF binding). The results obtained with CF show that the binding of CF (and probably also RR) to the laminae rarae is electrostatic in nature since it is displaced by treatment with buffers of high ionic strength or pH. With RR the sites resemble in morphology and staining properties the proteoglycan particles found in connective tissue matrices and in association with basement membranes in several other locations.
Immobilization of polyethylene oxide surfactants for non-fouling biomaterial surfaces using an argon glow discharge treatment (1993)

A non-fouling (protein-resistant) polymer surface is achieved by the covalent immobilization of polyethylene oxide (PEO) surfactants using an inert gas discharge treatment. Treated surfaces have been characterized using electron spectroscopy for chemical analysis (ESCA), static secondary ion mass spectrometry (SSIMS), water contact angle measurement, fibrinogen adsorption, and platelet adhesion. This paper is intended to review our recent work in using this simple surface modification process to obtain wettable polymer surfaces in general, and non-fouling biomaterial surfaces in particular.
Long term growth and maintenance of stratified rat urothelium <i>in vitro</i> (1989)

Culture conditions that allow long term growth and maintenance of rat urothelium have been determined using short (3 to 8 days) and long (14 to 60 days) term measurements of cell density and tritiated thymidine incorporation as indices. The basal nutrient medium utilized was a mixture of 199 plus Ham's F 12 (1:1) supplemented with insulin (1 microgram/ml) and hydrocortisone (1 microgram/ml). Long term culture of urothelium seems to require porous collagen. Porous albumin, or plastic dishes thinly coated with albumin, collagen, fibronectin or mixtures thereof, did not support long term maintenance. Serum was required at a concentration of 5%, independent of other additives. Decreasing Ca++ levels below that normally found the basal medium (approximately 1 X 10(-3] to as low as 1 X 10(-4), resulted in increased short term proliferation, but decreased long term maintenance by causing a loss of stratification of the urothelium. Even a slight increase in Ca++ concentration from 1.0 to 1.5 X 10(-3) resulted in an inhibition of proliferation and an increase in the number of large flat cells which subsequently sloughed off in sheets. The deletion of either insulin, hydrocortisone or both, inhibited growth. The addition of epidermal growth factor (EGF) or its homologue, transforming growth factor (TGF-alpha), increased cell proliferation markedly and caused a variable increase in stratification. However, epithelium induced to rapid growth and proliferation with EGF, eventually exhausted its growth potential and died. TGF-beta 1, alone or in combination with either EGF or alpha-TGF, had no additional effect upon urothelial growth. Repeated transfers of urothelium by enzymatic dissociation led to decreased growth and maintenance potential. The data indicates that long term maintenance of stratified urothelium in culture requires a porous collagen substrate and fetal bovine serum together with hormonal requirements and concentrations of Ca++ that neither greatly stimulate nor inhibit growth.
Late-Onset Globoid Cell Leukodystrophy: Unusual Ultrastructural Pathology and Subtotal β-Galactocerebrosidase Deficiency (1990)

An 11-year-old girl was found to have severely reduced beta-galactocerebrosidase activity as evidence of late-onset globoid cell leukodystrophy, while her mother had almost normal enzyme activity in circulating white blood cells. Clinically, the patient showed a remitting course marked by seizures, ataxia, white-matter disease on computed tomographic scan, and reduced conduction velocities of peripheral nerves. Symptoms improved somewhat around the age of 10 years. Two sural nerve biopsies, performed 6 years apart, disclosed a demyelinating neuropathy. By electron microscopy, membrane-bound vacuolar lysosomes in Schwann cells of myelinated axons, unlike the typical needlelike inclusions seen in classic infantile globoid cell leukodystrophy, were present in both specimens. Thus, clinical, morphologic, and biochemical data in this patient--and her mother--emphasize, compared with past reports on late-onset globoid cell leukodystrophy, considerable variation in the nosologic spectrum of late-onset globoid cell leukodystrophy and conspicuous differences from classic infantile globoid cell leukodystrophy.
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. (1986)

As an important new reagent for studying the cAMP-dependent protein kinase, a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein. This synthetic peptide inhibits the protein kinase competitively with a Ki = 2.3 nM; its sequence, Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr- Gly-Arg-Arg-Asn-Ala-Ile-His-Asp, is that of a peptide previously reported by us which was derived from the native inhibitor protein by V8 protease digestion (Cheng, H. C., Van Patten, S. M., Smith, A. J., and Walsh, D. A. (1985) Biochem. J. 231, 655-661). Studies with analogues of this peptide show that its high affinity binding to the protein kinase (as also of the inhibitor protein) appears to be due to it mimicking the protein substrate by binding to the catalytic site via the arginine-cluster basic subsite (Formula: see text), and also to a critical contribution from one or more of the 6 N-terminal residues (Formula: see text). The availability of this high affinity synthetic peptide should open up a variety of avenues to probe the cellular actions of cAMP.
Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. (1997)

Correct regulation of the segment-restricted patterns of Hox gene expression is essential for proper patterning of the vertebrate hindbrain. We have examined the molecular basis of restricted expression of Hoxb2 in rhombomere 4 (r4), by using deletion analysis in transgenic mice to identify an r4 enhancer from the mouse gene. A bipartite Hox/Pbx binding motif is located within this enhancer, and in vitro DNA binding experiments showed that the vertebrate labial-related protein Hoxb1 will cooperatively bind to this site in a Pbx/Exd-dependent manner. The Hoxb2 r4 enhancer can be transactivated in vivo by the ectopic expression of Hoxb1, Hoxa1, and Drosophila labial in transgenic mice. In contrast, ectopic Hoxb2 and Hoxb4 are unable to induce expression, indicating that in vivo this enhancer preferentially responds to labial family members. Mutational analysis demonstrated that the bipartite Hox/Pbx motif is required for r4 enhancer activity and the responses to retinoids and ectopic Hox expression. Furthermore, three copies of the Hoxb2 motif are sufficient to mediate r4 expression in transgenic mouse embryos and a labial pattern in Drosophila embryos. This reporter expression in Drosophila embryos is dependent upon endogenous labial and exd, suggesting that the ability of this Hox/Pbx site to interact with labial-related proteins has been evolutionarily conserved. The endogenous Hoxb2 gene is no longer upregulated in r4 in Hoxb1 homozygous mutant embryos. On the basis of these experiments we conclude that the r4-restricted domain of Hoxb2 in the hindbrain is the result of a direct cross-regulatory interaction by Hoxb1 involving vertebrate Pbx proteins as cofactors. This suggests that part of the functional role of Hoxb1 in maintaining r4 identity may be mediated by the Hoxb2 gene.