gebhart/patrepeval huggingface dataset:
Surface Forces between Plasma Polymer Films (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface Forces between Plasma Polymer FilmsJohn L. Parker, Per M. Claesson, Jenn-Hann Wang, and H. K. YasudaCite this: Langmuir 1994, 10, 8, 2766–2773Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/la00020a043https://doi.org/10.1021/la00020a043research-articleACS PublicationsRequest reuse permissionsArticle Views253Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PRIOR TRAINING INCREASES COLLATERAL BLOOD FLOW IN RATS FOLLOWING ACUTE FEMORAL ARTERY LIGATION 1026 (1996)

Endurance exercise training is know to increase vascular capacity and enhance vasoresponsiveness of feed arteries and large conduit vessels. We evaluated whether similar changes could modify pre-existing collateral vessels to improve collateral blood flow (BF) subsequent to acute femoral artery occlusion. Adult male Sprague-Dawley rats (-350 g) were trained (n=12) by treadmill running at 30 m/min, for 60 min/d, 5 d/wk for 6 wk, or limited to cage activity (sedentary; n=13). Training increased muscle citrate synthase activity (p<0.001). Collateral-dependent BFs were determined (85Sr& 141Ce μspheres) while running at 2 speeds (25 & 30 m/min) 4-6h following bilateral femoral artery ligation. Maximal collateral-dependent BFs were obtained, as calf muscle BFs were not further increased by the higher running speed. BFs were higher in the trained group (P<0.01; cf.Figure) even though aortic pressures were similar(150-160 mmHg). These data suggest that prior exercise training can`condition' (expand And/or better dilate?) pre-existing conduit vessels to optimize collateral-dependent BF immediately following obstruction of a primary distal artery.
Interferon-α 2b reduces phosphorylation and activity of MEK and ERK through a Ras/Raf-independent mechanism (2000)

Interferon (IFN)-alpha affects the growth, differentiation and function of various cell types by transducing regulatory signals through the Janus tyrosine kinase/signal transducers of activation and transcription (Jak/STAT) pathway. The signalling pathways employing the mitogen-activated ERK-activating kinase (MEK) and the extracellular-regulated kinase (ERK) are critical in growth factors signalling. Engagement of the receptors, and subsequent stimulation of Ras and Raf, initiates a phosphorylative cascade leading to activation of several proteins among which MEK and ERK play a central role in routing signals critical in controlling cell development, activation and proliferation. We demonstrate here that 24-48 h following treatment of transformed T- and monocytoid cell lines with recombinant human IFN-alpha2b both the phosphorylation and activity of MEK1 and its substrates ERK1/2 were reduced. In contrast, the activities of the upstream molecules Ras and Raf-1 were not affected. No effect on MEK/ERK activity was observed upon short-term exposure (1-30 min) to IFN. The anti-proliferative effect of IFN-alpha was increased by the addition in the culture medium of a specific inhibitor of MEK, namely PD98059. In conclusion, our results indicate that IFN-alpha regulates the activity of the MEK/ERK pathway and consequently modulates cellular proliferation through a Ras/Raf-independent mechanism. Targeting the MEK/ERK pathway may strengthen the IFN-mediated anti-cancer effect.
Involvement of the relA gene in the autolysis of Escherichia coli induced by inhibitors of peptidoglycan biosynthesis (1985)

It is generally assumed that inhibitors of peptidoglycan biosynthesis do not kill nongrowing bacteria. An exceptional case is reported here. The addition of chloramphenicol to amino acid-deprived cultures of relA+ strains of Escherichia coli which were treated with beta-lactam antibiotics, D-cycloserine, or moenomycin resulted in lysis. This phenomenon is termed chloramphenicol-dependent lysis. To be effective, chloramphenicol had to be present at its minimum growth-inhibitory concentration (or higher). Analogs of chloramphenicol which did not bind to ribosomes were completely ineffective. Amino acid deprivation was actually not required to demonstrate chloramphenicol-dependent lysis, and cultures treated with growth-inhibitory levels of chloramphenicol alone were lysed when challenged with inhibitors of peptidoglycan synthesis. Peptidoglycan synthesis has been shown previously to be under stringent (relA+) control, and chloramphenicol is known to be an antagonist of stringent control. Thus, it is proposed that the mechanism of chloramphenicol-dependent lysis is based on the ability of chloramphenicol to relax peptidoglycan synthesis in nongrowing relA+ bacteria. This is also consistent with the observation that treatment of amino acid-deprived relA mutants with inhibitors of peptidoglycan synthesis resulted in lysis, i.e., without the mediation of chloramphenicol.
Heparin/chitosan nanoparticle carriers prepared by polyelectrolyte complexation (2007)

In this study, novel nanoparticles were prepared by polyelectrolyte complexation between heparin and chitosan on simple and mild conditions. The size, polydispersity, zeta potential, and morphology of the nanoparticles were characterized. Entrapment studies of the nanoparticles were conducted using bovine serum albumin (BSA) as a model protein. Specifically, the effects of the pH value of chitosan solution, chitosan molecular weight (MW), chitosan concentration, heparin concentration, and BSA concentration on the nanoparticle size, the nanoparticle yield, and BSA entrapment were studied in detail. We found that, the size and the yield of the nanoparticles were affected by the above factors. The nanoparticle yield played a crucial role in BSA entrapment, namely, more nanoparticles could encapsulate more BSA. At length, suitably high pH value of chitosan solution, moderate chitosan MW, increasing both heparin concentration and chitosan concentration at an optimal concentration ratio favored more nanoparticles formed and consequently a higher BSA entrapment efficiency.
&lt;title&gt;Multicast for savings in cache-based video distribution&lt;/title&gt; (1999)

Internet video-on-demand (VoD) today streams videos directly from server to clients, because re-distribution is not established yet. Intranet solutions exist but are typically managed centrally. Caching may overcome these management needs, however existing web caching strategies are not applicable because they work in different conditions. We propose movie distribution by means of caching, and study the feasibility from the service providers' point of view. We introduce the combination of our reliable multicast protocol LCRTP for caching hierarchies combined with our enhancement to the patching technique for bandwidth friendly True VoD, not depending on network resource guarantees.
Determination of Sequence Distribution in Styrene-Butadiene Copolymer I. 1H-NMR Study of Styrene Oligomers (1981)

Abstract The 1 H-NMR spectra of styrene oligomers were measured as a model of styrene sequences in SBR. The ortho -phenyl proton, methine proton, and methylene proton signals shift to a higher magnetic field as the degree of polymerization increased. The methine proton signal split into two peaks, reflecting the tacticity. The methylene proton flanked by methylene and methine protons had a higher chemical shift value than the methylene proton flanked by two methine protons. It is demonstrated that the average sequence length of the styrene units in SBR can be determined by the relative intensity ratio of the two methylene proton signals. It is also found that the fraction of styrene sequences longer than 6 units can be estimated from the relative intensity of ortho -phenyl proton signals resonated higher than 6.7 ppm.
Microbial production of the aromatic building‐blocks (<i>S</i>)‐styrene oxide and (<i>R</i>)‐1,2‐phenylethanediol from renewable resources (2013)

(S)-Styrene oxide and (R)-1,2-phenylethanediol are chiral aromatic molecular building blocks used commonly as precursors to pharmaceuticals and other specialty chemicals. Two pathways have been engineered in Escherichia coli for their individual biosynthesis directly from glucose. The novel pathways each constitute extensions of the previously engineered styrene pathway, developed by co-expressing either styrene monooxygenase (SMO) or styrene dioxygenase (SDO) to convert styrene to (S)-styrene oxide and (R)-1,2-phenylethanediol, respectively. StyAB from Pseudomonas putida S12 was determined to be the most effective SMO. SDO activity was achieved using NahAaAbAcAd of Pseudomonas sp. NCIB 9816-4, a naphthalene dioxygenase with known broad substrate specificity. Production of phenylalanine, the precursor to both pathways, was systematically enhanced through a number of mutations, most notably via deletion of tyrA and over-expression of tktA. As a result, (R)-1,2-phenylethanediol reached titers as high as 1.23 g/L, and at 1.32 g/L (S)-styrene oxide titers already approach their toxicity limit. As with other aromatics, product toxicity was strongly correlated with a model of membrane accumulation and disruption. This study additionally demonstrates that greater flux through the styrene pathway can be achieved if its toxicity is addressed, as achieved in this case by reacting styrene to less toxic products.
IslandPath: aiding detection of genomic islands in prokaryotes (2003)

An online help file, which includes analyses of the utility of IslandPath, can be found at http://www.pathogenomics.sfu.ca/islandpath/current/islandhelp.html
Comparison of the MicroScan system with the API Staph-Ident system for species identification of coagulase-negative staphylococci (1986)

To evaluate the accuracy of the MicroScan System (American Hospital Supply Corp., Sacramento, Calif.) for identification of coagulase-negative staphylococci, we tested 175 clinical isolates of coagulase-negative staphylococci. The results obtained by the MicroScan system were compared with those of the API Staph-Ident system (Analytab Products, Plainview, N.Y.). Forty-three discrepancies between the two systems were resolved by the conventional method of Kloos and Schleifer (W.E. Kloos and K.H. Schleifer, J. Clin. Microbiol. 1:82-88, 1975). The MicroScan and the Staph-Ident systems correctly identified 146 (86.4%) and 154 (88%) of 175 strains, respectively. The API system failed to identify phosphatase-negative Staphylococcus epidermidis. The MicroScan system demonstrated the greatest accuracy in the identification of S. epidermidis and S. saprophyticus, whereas lesser accuracy was achieved with S. hominis, S. warneri, and S. sciuri.
Automatic pre-crash collision avoidance in cars (2004)

In recent years, a number of European Commission funded projects have investigated how the objective of increasing pedestrian safety can be attained by means of intelligent driver assistance systems. The results already at disposal show that, while in the long range case, a warning system, to alert the driver as soon as a vulnerable road users (VRU) is detected and classified by the sensors, can be sufficient to reduce the number of accidents, an active intervention system is mandatory in pre-crash situations. In this paper, an automatic pre-crash collision avoidance strategy for cars is presented. It produces a collision avoidance manoeuvre, if feasible, or, otherwise, an emergency braking to reduce the energy at the impact.
Suppression of Choroidal Neovascularization by Dendritic Cell Vaccination Targeting VEGFR2 (2007)

These results indicate that the VEGFR2 peptide-specific induction of cellular immunity inhibits CNV through the cytotoxicity of CD8 T cells. Results of the present study suggested the possibility of DC vaccination targeting VEGFR2 as a novel therapeutic strategy for CNV.
Two-level coding for error control in magnetic disk storage products (1989)

Error-control coding has played a significant role in the design and development of magnetic recording storage products. The trend toward higher densities and data rates presents continuing demands for an ability to operate at a lower signal-to-noise ratio and to tolerate an increased number of correctable errors. Heretofore, the magnetic disk storage products used coding schemes that provided correction of one burst of errors in a record of length ranging from a few bytes of data to a full track on the disk. In this paper, we present a new coding architecture that facilitates correction of multiple-burst errors in each record in a typical disk storage application. This architecture embodies a two-level coding scheme which offers high coding efficiency along with a fast decoding strategy that closely matches the requirements of on-line correction of multiple bursts of errors. The first level has a smaller block delay and provides very fast correction of most of the errors commonly encountered in an average disk file. The second level, on a larger block size, provides reserve capability for correcting additional errors which may be encountered in a device with symptoms of a weaker component or an oncoming failure. The new IBM 3380J and 3380K disk files use a two-level scheme that is designed around the coding structure of the extended Reed-Solomon code. This design and the related encoding and decoding methods and implementation are presented in detail.
Anisotropic Poly(Ethylene Glycol)/Polycaprolactone Hydrogel–Fiber Composites for Heart Valve Tissue Engineering (2014)

The recapitulation of the material properties and structure of the native aortic valve leaflet, specifically its anisotropy and laminate structure, is a major design goal for scaffolds for heart valve tissue engineering. Poly(ethylene glycol) (PEG) hydrogels are attractive scaffolds for this purpose as they are biocompatible, can be modified for their mechanical and biofunctional properties, and can be laminated. This study investigated augmenting PEG hydrogels with polycaprolactone (PCL) as an analog to the fibrosa to improve strength and introduce anisotropic mechanical behavior. However, due to its hydrophobicity, PCL must be modified prior to embedding within PEG hydrogels. In this study, PCL was electrospun (ePCL) and modified in three different ways, by protein adsorption (pPCL), alkali digestion (hPCL), and acrylation (aPCL). Modified PCL of all types maintained the anisotropic elastic moduli and yield strain of unmodified anisotropic ePCL. Composites of PEG and PCL (PPCs) maintained anisotropic elastic moduli, but aPCL and pPCL had isotropic yield strains. Overall, PPCs of all modifications had elastic moduli of 3.79±0.90 MPa and 0.46±0.21 MPa in the parallel and perpendicular directions, respectively. Valvular interstitial cells seeded atop anisotropic aPCL displayed an actin distribution aligned in the direction of the underlying fibers. The resulting scaffold combines the biocompatibility and tunable fabrication of PEG with the strength and anisotropy of ePCL to form a foundation for future engineered valve scaffolds.
Biological and Molecular Characteristics of Interleukin-5 and its Receptor (1998)

Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders. T cells purified from bronchoalveolar lavage and peripheral blood of asthmatics secrete elevated amount of IL5. Therefore IL5 emerges to be an attractive target for the generation of new anti-allergic drugs. Agents which inhibit either the production or the activity of IL5 could be expected to ameliorate the pathological effects of the allergic response. A better understanding of the biology of IL5 and the regulation of its expression is, however, a prerequisite for the development of new therapeutic agents. This review covers the major biological, molecular and structural aspects of IL5 research since the identification of this cytokine ten years ago.
Description of a New Species, Oerskovia xanthineolytica, and Emendation of Oerskovia Prauser et al. (1972)

A new species belonging to the genus Oerskovia Prauser et al. of the order Actionmycetales is described under the name O. xanthineolytica. It differs from O. turbata mainly in its ability to hydrolyze xanthine and hypoxanthine, in certain carbohydrate reactions, in the production of a phosphatase, and in its ability to grow at 42 C on Trypticase-soy agar. The type strain of this species is IMRU 3959 (LL G62) (=ATCC 27402). The description of the genus Oerskovia is emended to take into account the fact that members of this genus can grow anaerobically on Trypticase-soy medium with the production of catalase-negative biomasses.
Cyclin D1 Amplification and p16(MTS1/CDK4I) Deletion Correlate With Poor Prognosis in Head and Neck Tumors (2002)

We demonstrate that FISH is a simple and sensitive method for detecting cyclin D1 amplification and p16 deletion in head and neck cancer. Our results suggest that these two genetic aberrations together portend a poorer outcome than either of the abnormalities alone in head and neck cancer.
Wavelet-based Bayesian denoising using Bernoulli-Gaussian mixture model (2005)

In general, wavelet coefficients are composed of a few large coefficients and a lot of small ones. Therefore, each wavelet coefficient is efficiently modeled as a random variable of a Bernoulli-Gaussian mixture distribution with unknown parameters. The Bernoulli-Gaussian mixture is composed of the multiplication of the Bernoulli random variable and the Gaussian mixture random variable. In this paper, we propose a denoising algorithm using the Bernoulli-Gaussian mixture model based on sparse characteristics of the wavelet coefficient. The denoising is performed with Bayesian estimation. We present an effective denoising method through simplified parameter estimation for the Bernoulli random variable using a local expected square error. Simulation results showed that our method outperformed the states of the art denoising methods.
Gender difference and sex hormone production in rodent renal ischemia reperfusion injury and repair (2011)

After ischemia, renal function recovery and tissue injury is gender-dependent. These differences are associated with a modulation of sex hormone production and a modification of tissue remodeling and proliferative cell processes.
Postnatally Induced Inactivation of gp130 in Mice Results in Neurological, Cardiac, Hematopoietic, Immunological, Hepatic, and Pulmonary Defects (1998)

The pleiotrophic but overlapping functions of the cytokine family that includes interleukin (IL)-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin 1 are mediated by the cytokine receptor subunit gp130 as the common signal transducer. Although mice lacking individual members of this family display only mild phenotypes, animals lacking gp130 are not viable. To assess the collective role of this cytokine family, we inducibly inactivated gp130 via Cre-loxP-mediated recombination in vivo. Such conditional mutant mice exhibited neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects, demonstrating the widespread importance of gp130-dependent cytokines.
Disease–Drug–Drug Interaction Involving Tocilizumab and Simvastatin in Patients With Rheumatoid Arthritis (2011)

In rheumatoid arthritis (RA), interleukin-6 (IL-6) concentration is elevated, which may cause reduced cytochrome P450 (CYP) activity and increased exposure (peak plasma concentration and area under the plasma concentration-vs.-time curve (AUC)) to certain drugs. Tocilizumab may reverse IL-6-induced suppression of CYP3A4 activity. In this study, exposure to simvastatin was significantly reduced at 1 and 5 weeks after tocilizumab infusion in 12 patients with RA. The mean effect ratio for simvastatin AUC(last) was 43% (90% confidence interval (CI), 34-55%) at 1 week after tocilizumab infusion (day 15) and 61% (90% CI, 47-78%) at 5 weeks after tocilizumab infusion, as compared with baseline (day 1); both ratios were significantly lower than the bioequivalence boundary (80-125%). Mean plasma C-reactive protein (CRP) levels normalized within 1 week after tocilizumab was initiated; the time course of tocilizumab's CRP-reducing effect paralleled that of simvastatin pharmacokinetics. The study findings suggest that caution should be exercised when starting tocilizumab in RA patients who are taking simvastatin.
8-W coherently phased 4-element fiber array (2003)

A four-element fiber array has been constructed to yield 8 watts of coherently phased, linearly polarized light energy in a single far field spot. Each element consists of a 2-W single-mode fiber-amplifier chain. Phase control of each element is achieved with a lithium-niobate phase modulator. A master laser provides a linearly polarized, narrow linewidth signal that is split into five channels. Four channels are individually amplified using polarization maintaining fiber power amplifiers. Frequency broadening of the signal is necessary to avoid stimulated Brillouin scattering. The fifth channel is used as a reference arm. It is frequency shifted and then combined interferometrically with a portion of each channel's signal. Detectors sense the heterodyne modulation signal, and an electronics circuit measures the relative phase for each channel. Compensating adjustments are then made to each channel's phase modulator. The stability of the optical train is an essential contributor to its success. A state-of-the-art interferometer was built with mountless optics. A lens array was constructed using nano-positioning tolerances, where each lens was individually aligned to its respective fiber to collimate its output and point it at a common far field spot. This system proved to be highly robust and handled any acoustic perturbations.
Ambulatory Blood Pressure Monitoring Is Associated With Reduced Physical Activity During Everyday Life (1999)

Ambulatory blood pressure recording using automated sphygmomanometers is associated with reduced physical activity during the monitoring day. This is due partly to regular periods of immobility during cuff inflation and deflation and diary completion and partly to more general self-imposed restrictions on activity. This pattern has implications for the representativeness of ambulatory blood pressure monitoring, and the construction of ambulatory monitoring diaries.