gebhart/patrepeval huggingface dataset:
Central Role for the Cardiotonic Steroid Marinobufagenin in the Pathogenesis of Experimental Uremic Cardiomyopathy (2006)

Patients with chronic renal failure develop a "uremic" cardiomyopathy characterized by diastolic dysfunction, cardiac hypertrophy, and systemic oxidant stress. Patients with chronic renal failure are also known to have increases in the circulating concentrations of the cardiotonic steroid marinobufagenin (MBG). On this background, we hypothesized that elevations in circulating MBG may be involved in the cardiomyopathy. First, we observed that administration of MBG (10 microg/kg per day) for 4 weeks caused comparable increases in plasma MBG as partial nephrectomy at 4 weeks. MBG infusion caused increases in conscious blood pressure, cardiac weight, and the time constant for left ventricular relaxation similar to partial nephrectomy. Decreases in the expression of the cardiac sarcoplasmic reticulum ATPase, cardiac fibrosis, and systemic oxidant stress were observed with both MBG infusion and partial nephrectomy. Next, rats were actively immunized against a MBG-BSA conjugate or BSA control, and partial nephrectomy was subsequently performed. Immunization against MBG attenuated the cardiac hypertrophy, impairment of diastolic function, cardiac fibrosis, and systemic oxidant stress seen with partial nephrectomy without a significant effect on conscious blood pressure. These data suggest that the increased concentrations of MBG are important in the cardiac disease and oxidant stress state seen with renal failure.
Microcode compaction (1981)

The past decade has seen significant advances in the state of the art in microcode compaction. Microprograms are compacted by placing several microoperations into each microinstruction, subject to the constraints of data dependency in the program and legal resource usage in the machine on which the microcode will execute. The compaction process attempts to make the code run as fast as possible. In this paper we will not only survey the most recent past in microcode compaction but will also speculate about the near future.
A technique for estimating 4D‐CBCT using prior knowledge and limited‐angle projections (2013)

The MM-FD technique substantially improves the estimation accuracy for onboard 4D-CBCT using prior planning 4D-CT and limited-angle projections, compared to the MM-only and FD-only techniques. It can potentially be used for the inter/intrafractional 4D-localization verification.
Silicon photovoltaic cells in thermophotovoltaic energy conversion (1978)

A new silicon photovoltaic cell has been developed for use in a thermophotovoltaic (TPV) energy converter. Attention has been paid to minimizing parasitic absorptance and optimizing electrical performance. Energy conversion efficiencies of 26 percent in TPV operation were measured at an output power density of 10 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Isolation and Molecular Characterization of a Serotype 9 Human Rotavirus Strain (1990)

A human rotavirus strain, designated AU32, that belongs to serotype 9 was isolated and was compared by RNA-RNA hybridization with recently established two serotype 9 strains (WI61 and F45) as well as other prototype human strains. These three strains exhibited a very high degree of homology with one another and shared a high degree of homology with strains belonging to the Wa genogroup but not with strains belonging to either the DS-1 or AU-1 genogroup. These results suggest that genetic constellation of the serotype 9 strains is similar to that of the commonest human rotavirus despite the recent recognition of this serotype.
Carbon Dioxide Released from Human Skin: Effect of Temperature and Insect Repellents (1992)

Measurement with an infrared analyzer of CO2 given off by the hands of human volunteers under laboratory conditions showed that they continuously produced CO2 at the rate of 1.0-1.8 ml/h. Increased production of CO2 was observed with increase in temperature for all subjects. Treatment of subjects with three insect repellents or ethanol resulted in a short-term drop in CO2 production, after which it returned to pretreatment levels. Olfactometer studies showed no correlation between the amount of CO2 produced by hands and the attractancy of the subjects to host-seeking female Ae. aegypti (L.). The supplemental addition of five times the amount of CO2 given off by the hands did not affect attractancy of subjects to mosquitoes. The amount of CO2 released by hands is negligible compared to ambient levels of 300 ppm, and it is unlikely to be attractive at this level of release by itself.
Classification and Semantic Mapping of Urban Environments (2010)

In this paper we address the problem of classifying objects in urban environments based on laser and vision data. We propose a framework based on Conditional Random Fields (CRFs), a flexible modeling tool allowing spatial and temporal correlations between laser returns to be represented. Visual features extracted from color imagery as well as shape features extracted from 2D laser scans are integrated in the estimation process. The paper contains the following novel developments: (1) a probabilistic formulation for the problem of exploiting spatial and temporal dependencies to improve classification; (2) three methods for classification in 2D semantic maps; (3) a novel semi-supervised learning algorithm to train CRFs from partially labeled data; (4) the combination of local classifiers with CRFs to perform feature selection on high-dimensional feature vectors. The system is extensively evaluated on two different datasets acquired in two different cities with different sensors. An accuracy of 91% is achieved on a seven-class problem. The classifier is also applied to the generation of a 3 km long semantic map.
Growth support and toxicity of homocysteine and its effects on methionine metabolism in non-transformed and chemically transformed C3H/10T1/2 cells (1988)

The effects of homocysteine (Hcy) on one non-transformed (Cl 8) and two malignant clones (Cl 16 and Cl T422) of the C3H/10T1/2 mouse embryo fibroblasts, were examined with regard to toxicity, ability to support growth and effects on methionine (Met) metabolism and glutathione level. Homocysteine in its reduced form (Hcy-SH) was toxic to all cell lines, and the LD90 was estimated to be 1.0 X 10(-4) M for Cl 8 and Cl 16 cells measured by plating efficiency, 0.8 X 10(-4) M for Cl 8 and 0.3 X 10(-4) M for Cl 16 when measured by total cell growth. At toxic concentrations, Hcy-SH showed a drastic effect on cell morphology both in the presence and absence of Met. The same effect was demonstrated with L-cysteine. No toxic effect was seen with homocystine (Hcy-SS-Hcy) or homocysteine thiolactone (Hcy-tl) at similar concentrations. Hcy-tl supported growth of both the non-transformed and malignant cells in Met-deficient medium but with decreasing efficiency in the order Cl 8, Cl 16 and Cl T422. The growth rate constant compared to that of Met-supplemented medium was 0.62 for Cl 8, 0.44 for Cl 16 and 0.38 for Cl T422 cells. The intracellular level of S-adenosylhomocysteine (AdoHcy) increased in all three cell lines in Hcy-tl-supplemented medium. The S-adenosylmethionine (AdoMet) content increased in Cl 8 cells, was constant in Cl 16 cells and decreased in Cl T422 cells under the same conditions. This resulted in a constant ratio of AdoMet/AdoHcy in the non-transformed cells (Cl 8) whereas this ratio decreased by 40% in Cl 16 and by 72% in Cl T422 cells when Hcy-tl replaced Met in the medium. The ability of Hcy-tl to support growth thus seemed to correlate well with alteration in Met metabolism in this cell culture system. The intracellular level of glutathione (GSH) was measured during exponential growth, but showed small variations between non-transformed cells and Cl 16 cells. However, Cl T422 cells showed a distinct lower level of GSH in Met-supplemented medium, and this increased 3- to 4-fold when Met was replaced with Hcy-tl.
Systematic review: tolerable amount of gluten for people with coeliac disease (2008)

The amount of tolerable gluten varies among people with coeliac disease. Although there is no evidence to suggest a single definitive threshold, a daily gluten intake of <10 mg is unlikely to cause significant histological abnormalities.
Learning patterns of activity using real-time tracking (2000)

Our goal is to develop a visual monitoring system that passively observes moving objects in a site and learns patterns of activity from those observations. For extended sites, the system will require multiple cameras. Thus, key elements of the system are motion tracking, camera coordination, activity classification, and event detection. In this paper, we focus on motion tracking and show how one can use observed motion to learn patterns of activity in a site. Motion segmentation is based on an adaptive background subtraction method that models each pixel as a mixture of Gaussians and uses an online approximation to update the model. The Gaussian distributions are then evaluated to determine which are most likely to result from a background process. This yields a stable, real-time outdoor tracker that reliably deals with lighting changes, repetitive motions from clutter, and long-term scene changes. While a tracking system is unaware of the identity of any object it tracks, the identity remains the same for the entire tracking sequence. Our system leverages this information by accumulating joint co-occurrences of the representations within a sequence. These joint co-occurrence statistics are then used to create a hierarchical binary-tree classification of the representations. This method is useful for classifying sequences, as well as individual instances of activities in a site.
Assessing the feet of patients with diabetes. (2000)

Diabetic foot complications are common and often result in recurrent morbid events. Several studies have indicated that prevention practices are effective in preventing the development of foot ulcers and amputations. The first step in a lower-extremity ulcer prevention program is a systematic foot examination and risk stratification to select patients for more intensive prevention efforts. We provide current information on the components that should be indicated in a lower-extremity screening history and physical evaluation and a diabetic foot risk-classification scheme.
The Kru¨ppel-like Factor KLF15 Regulates the Insulin-sensitive Glucose Transporter GLUT4 (2002)

Resistance to the stimulatory effects of insulin on glucose utilization is a key feature of type 2 diabetes, obesity, and the metabolic syndrome. Recent studies suggest that insulin resistance is primarily caused by a defect in glucose transport. GLUT4 is the main insulin-responsive glucose transporter and is expressed predominantly in muscle and adipose tissues. Whereas GLUT4 has been shown to play a critical role in maintaining systemic glucose homeostasis, the mechanisms regulating its expression are incompletely understood. We have cloned the murine homologue of KLF15, a member of the Krüppel-like family of transcription factors. KLF15 is highly expressed in adipocytes and myocytes in vivo and is induced when 3T3-L1 preadipocytes are differentiated into adipocytes. Overexpression of KLF15 in adipose and muscle cell lines potently induces GLUT4 expression. This effect is specific to KLF15 as overexpression of two other Krüppel-like factors, KLF2/LKLF and KLF4/GKLF, did not induce GLUT4 expression. Both basal (3.3-fold, p < 0.001) and insulin-stimulated (2.4-fold, p < 0.00001) glucose uptake are increased in KLF15-overexpressing adipocytes. In co-transfection assays, KLF15 and MEF2A, a known activator of GLUT4, synergistically activates the GLUT4 promoter. Promoter deletion and mutational analyses provide evidence that this activity requires an intact KLF15-binding site proximal to the MEF2A site. Finally, co-immunoprecipitation assays show that KLF15 specifically interacts with MEF2A. These studies indicate that KLF15 is an important regulator of GLUT4 in both adipose and muscle tissues.
Superficial bladder tumours: recurrence and progression. (2011)

The number of patients with T1 disease was 45% in this study which is comparatively higher than other studies. Early recurrences and progression were observed with T1G2-3, while late recurrence were seen with Ta disease, having tumour free interval between 6 months to 2 years. Early radical cystectomy was advised to T1G3 disease and with multiple recurrences, but patient's compliance was poor..
Critical success factors for integration of CAD/CAM systems with ERP systems (2001)

Current advances in information technology and, in particular, computer‐aided design/computer‐aided manufacturing (CAD/CAM) and enterprise resources planning (ERP) systems, have led organisations to undertake significant investments in these systems. Next generation manufacturers require both systems to maintain or gain a competitive advantage, reduce risks and improve productivity and viability. In addition, recent attention to the implementation of CAD/CAM systems highlights their important role in automating complex design and next generation manufacturing processes. In the next millennium more manufacturers are likely to implement CAD/CAM and ERP systems and hence issues in the integration of CAD/CAM with ERP systems must become a major concern. Accordingly, this paper will: explore the problems of integration of CAD/CAM systems with ERP systems; study how the severity of these problems relates to CAD/CAM integration success; propose a set of critical success factors (CSF) for the integration of CAD/CAM with ERP systems; suggest hypotheses to study the relevance of these CSF for successful integration of CAD/CAM with ERP systems. In addition, the paper also demonstrates the importance of successful integration of CAD/CAM systems with other applications for next generation manufacturers. These findings suggest that integration of CAD/CAM systems with ERP systems is complex, involving many factors.
Non‐Invasive Measurements of Skin Pigmentation In Situ (2004)

Objective in situ measurements of skin pigmentation are needed for accurate documentation of pigmentation disorders, in studies of constitutive and induced skin pigmentation, for testing of the efficacy of pro-pigmentation or de-pigmentation agents, etc. Non-invasive instrumental measurements of skin pigmentation have been used for many decades. All are based on the ability of melanin to attenuate light. However, hemoglobin in dermal capillaries also attenuates light and needs to be accounted for when pigmentation is assessed. The methods under consideration include: (a) single point measurements, in which light reflected from a defined skin area is collected and a pigment index is calculated representing the average pigmentation over the examined area, and (b) imaging methods that attempt to generate a concentration distribution map of melanin pigment for the skin area being imaged. In this article, we describe the potentials and the limitations of the different approaches to both single point and imaging methods.
Desorption electrospray ionisation mass spectrometry and tandem mass spectrometry of low molecular weight synthetic polymers (2006)

A range of low molecular weight synthetic polymers has been characterised by means of desorption electrospray ionisation (DESI) combined with both mass spectrometry (MS) and tandem mass spectrometry (MS/MS). Accurate mass experiments were used to aid the structural determination of some of the oligomeric materials. The polymers analysed were poly(ethylene glycol) (PEG), polypropylene glycol (PPG), poly(methyl methacrylate) (PMMA) and poly(alpha-methyl styrene). An application of the technique for characterisation of a polymer used as part of an active ingredient in a pharmaceutical tablet is described. The mass spectra and tandem mass spectra of all of the polymers were obtained in seconds, indicating the sensitivity of the technique.
N-terminal portion acts as an initiator of the inactivation of pepsin at neutral pH (2001)

Porcine pepsin, an aspartic protease, is unstable at neutral pHs where it rapidly loses activity, however, its zymogen, pepsinogen, is stable at neutral pHs. The difference between the two is the presence of the prosegment in pepsinogen. In this study, possible factors responsible for instability were investigated and included: (i) the distribution of positively charged residues on the surface, (ii) an insertion of a peptide in the C-terminal domain and (iii) the dissociation of the N-terminal fragment of pepsin. Mutations to change the number and the distribution of positive charges on the surface had a minor effect on stability. No effect on stability was observed for the deletion of a peptide from the C-terminal domain. However, mutations on the N-terminal fragment had a major impact on stability. At pH 7.0, the N-fragment mutant was inactivated 5.8 times slower than the wild-type. The introduction of a disulfide bond between the N-terminal fragment and the enzyme body prevented the enzyme from denaturing. The above results showed that the inactivation of pepsin was initiated by the dissociation of the N-fragment and that the sequence of this portion was a major determinant for enzyme stability. Through this study, we have created porcine pepsin with increased pH stability at neutral pHs.
Ion Exchange Reactions of Clays (1955)

Abstract It has been recognized for many years that many aspects of clay technology including soil treatment and drilling mud treatment must remain in an essentially empirical state until a basis for the understanding of ion exchange reactions is established. Much of the work on ion exchange reactions of clays in the past has been directed toward establishing total exchange capacities or determining the ionic distribution empirically. This information in general is not suitable for the evaluation of hypotheses designed to provide a basis for understanding the exchange reaction. When the techniques for characterizing the various clay minerals offered the possibility of quantitative study, the solution and exchanger phase contributions to the ionic distribution could be experimentally evaluated in principle. The particular experimental techniques which have been used to measure ionic distribution, however, frequently neglected observations which are essential if the data are to he used for testing and developing theories of ion exchange. It is now well recognized that molecular adsorption, complex ion formation in solution, and ion-pair formation between a mobile solution ion and a fixed exchanger group may occur in addition to the ion exchange reaction. Therefore, if the data are to be useful to develop theories of ion exchange, the whole system must be selected to minimize such extraneous contributions. On the basis of recent theoretical work, various experimental techniques art; evaluated from the point of view of their suitability for equilibrium ion distribution studies. The mass action, adsorption isotherm, and Gibbs-Donnan equilibrium formulations of the ion exchange theory are discussed as they may apply to clay systems. Recent progress is summarized in (1) solution thermodynamics of mixed electrolytes as it is relevant to ion exchange processes of clays, (2) the contributions of non-ideality of the clay exchanger phase, and (S) the work of swelling of clays which affects the ionic distributions in ion exchange reactions. It is concluded that the parameters which relate to the solid phase of the exchanger and those which relate to the solution are now sufficiently well recognized that future experiments can be planned which may more realistically provide an experimental basis for understanding the process of equilibrium ion exchange distributions in aqueous clay-electrolyte systems.
Asymmetric Electrophilic Fluorination Using an Anionic Chiral Phase-Transfer Catalyst (2011)

The discovery of distinct modes of asymmetric catalysis has the potential to rapidly advance chemists' ability to build enantioenriched molecules. As an example, the use of chiral cation salts as phase-transfer catalysts for anionic reagents has enabled a vast set of enantioselective transformations. Here, we present evidence that a largely overlooked analogous mechanism wherein a chiral anionic catalyst brings a cationic species into solution is itself a powerful method. The concept is applied to the enantioselective fluorocyclization of olefins with a cationic fluorinating agent and a chiral phosphate catalyst. The reactions proceed in high yield and stereoselectivity, especially considering the scarcity of alternative approaches. This technology can in principle be applied to the large portion of reaction space that uses positively charged reagents and reaction intermediates.
Low-temperature wafer bonding: a study of void formation and influence on bonding strength (2005)

The void formation has been systematically observed for low-temperature (120/spl deg/C and 400/spl deg/C) Si-Si and SiO/sub 2/-SiO/sub 2/ wafer bonding techniques in function of the annealing time (from 70 to 595 h), pressure (low vacuum and atmospheric) and surface pretreatments. Mixed solution (H/sub 2/SO/sub 4/ and H/sub 2/O/sub 2/) standard cleaning, warm nitric acid and O/sub 2/-plasma-assisted surface pretreatments have been considered and compared. The void formation is clarified according to the void distribution and the measurement of surface energy. Long annealing time periods are considered in order to reach the saturation of the interface chemical reactions. Our experiments demonstrate that the origin of voids appearing in low temperature O/sub 2/-plasma-enhanced wafer bonding is related to the great quantity of chemical reaction products. It has been shown that optimized O/sub 2/-plasma pretreatment time can lead to void-free, uniform and high surface energy (over 2.0 J/m/sup 2/) wafer bonding. In the case of SiO/sub 2/-SiO/sub 2/ wafer bonding, our experimental results show that below a certain critical silicon dioxide thickness the reaction products cannot be absorbed totally and then voids occur. Presenting a higher surface energy than warm nitric acid O/sub 2/-plasma is an extremely promising surface pretreatment solution for the increasing demand of low-temperature wafer bonding techniques.
A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels (2003)

Cigarette smoking produces pulmonary hypertension (PHT) through unknown mechanisms. In animal models acute smoke exposure induces cell proliferation in the small arteries adjacent to the alveolar ducts, and chronic exposure results in muscularisation of these vessels, with changes related to the development of PHT. Studies indicate that serine-elastase inhibitors can prevent experimental monocrotaline-induced PHT. This study examined whether they could also prevent cigarette smoke-induced pulmonary vascular disease. Guinea-pigs were exposed to cigarette smoke or air for 6 months. Some animals also received ZD0892, an orally active, synthetic, selective, serine-elastase inhibitor. The percentage of muscularised, small, pulmonary arteries was determined by morphometric analysis of histological sections and vascular cell proliferation by proliferating cell nuclear antigen staining. Vascular cell proliferation was markedly increased in the smoke-exposed animals and the percentage of completely muscularised small vessels was increased four-fold. Cell proliferation indices correlated with muscularisation indices. In the animals treated with ZD0892, the number of completely muscularised vessels was reduced by 50% and cell proliferation was reduced by 61%. These data suggest that smoke-induced cell proliferation leads to pulmonary arterial muscularisation. Serine-elastase inhibitors appear to be able to reduce cell proliferation and vascular remodelling.