gebhart/patrepeval huggingface dataset:
Applications of multilingual text retrieval (1996)

The recent enormous increase in the use of networked information access and on-line databases has led to more databases being available in languages other than English. The Center for Intelligent Information Retrieval (CIIR) at the University of Massachusetts is involved in a variety of industrial government, and digital library applications which have a need for multilingual text retrieval. Most information retrieval research, however has been evaluated using English databases and queries, and relatively little is and own about how well advanced statistical techniques that incorporate ranking and term weight perform in different languages. We describe our experience with a range of projects involving text retrieval in Spanish, Japanese and Chinese. The issues covered by these projects include document representation techniques such as morphology and segmentation, query formulation and expansion techniques, relevance feedback and comparisons of retrieval effectiveness with English databases. The results indicate that advanced statistical techniques are effective in a wide range of languages, and that new languages can be incorporated with only moderate effort.
Separating the Anti-Inflammatory and Diabetogenic Effects of Glucocorticoids Through LXRβ Antagonism (2017)

Synthetic glucocorticoids (GCs), including dexamethasone (DEX), are powerful anti-inflammatory drugs. Long-term use of GCs, however, can result in metabolic side effects such as hyperglycemia, hepatosteatosis, and insulin resistance. The GC receptor (GR) and liver X receptors (LXRα and LXRβ) regulate overlapping genes involved in gluconeogenesis and inflammation. We have previously shown that Lxrβ-/- mice are resistant to the diabetogenic effects of DEX but still sensitive to its immunosuppressive actions. To determine whether this finding could be exploited for therapeutic intervention, we treated mice with GSK2033, a pan-LXR antagonist, alone or combined with DEX. GSK2033 suppressed GC-induced gluconeogenic gene expression without affecting immune-responsive GR target genes. The suppressive effect of GSK2033 on DEX-induced gluconeogenic genes was specific to LXRβ, was liver cell autonomous, and occurred in a target gene-specific manner. Compared with DEX treatment alone, the coadministration of GSK2033 with DEX decreased the recruitment of GR and its accessory factors MED1 and C/EBPβ to the phosphoenolpyruvate carboxykinase promoter. However, GSK2033 had no effect on DEX-mediated suppression of inflammatory genes expressed in the liver or in mouse primary macrophages stimulated with lipopolysaccharides. In conclusion, our study provides evidence that the gluconeogenic and immunosuppressive actions of GR activation can be mechanistically dissociated by pharmacological antagonism of LXRβ. Treatment with an LXRβ antagonist could allow the safer use of existing GC drugs in patients requiring chronic dosing of anti-inflammatory agents for the treatment of diseases such as rheumatoid arthritis and inflammatory bowel disease.
On Combining Artificial Neural Nets (1996)

This paper reviews research on combining artificial neural nets, and provides an overview of, and an introduction to, the papers contained in this special issue, and its companion (Connection Science, 9, 1). Two main approaches, ensemble-based, and modular, are identified and considered. An ensemble, or committee, is made up of a set of nets, each of which is a general function approximator. The members of the ensemble are combined in order to obtain better generalization performance than would be achieved by any of the individual nets. The main issues considered here under the heading of ensemble-based approaches are a how to combine the outputs of the ensemble members, b how to create candidate ensemble members and c which methods lead to the most effective ensembles? Under the heading of modular approaches, we begin by considering a divide-and-conquer approach by which a function is automatically decomposed into a number of subfunctions which are treated by specialist modules. Other modular approaches are also identified and considered, for while the divide-and-conquer approach is designed to improve performance, the term modularity can be given a wider interpretation. The broadly defined topic of modularity includes the explicit decomposition of a task based on the designer's understanding, and the exploitation of specialist modules in order to accomplish tasks which could not be performed by a monolithic net.
Coronary atherosclerosis. A multifactorial disease. (1993)

The possibility of retarding human atherosclerosis or even inducing its regression is one of the present therapeutic challenges. Of the different approaches to this question, one approach aims at better control of risk factors, especially plasma lipid levels. Another approach attempts to enhance the removal of lipids from the arterial wall by increasing plasma high density lipoprotein levels. Each of these approaches, by acting on the lipid-rich plaques more prone to rupture, might prevent plaque progression and induce regression to prevent acute coronary events. A third approach, based on the key role of platelet thrombus formation in the conversion of chronic to acute events, would be the use of antithrombotic therapy. This last approach may partially prevent progression of the disease.
Clinical assessment of noninvasive intracranial pressure absolute value measurement method (2012)

The proposed noninvasive ICP measurement method is precise and accurate compared with gold standard CSF pressure measured via lumbar puncture.
Application of dry-state adsorption condition (DSAC) Pauson-Khand cyclization for the synthesis of perhydrocyclopenta[c]pyrroles (2001)

A simplified protocol of dry-state adsorption condition (DSAC) Pauson-Khand cyclizations for the preparation of the title compounds and the synthesis of a variety of perhydrocyclopenta[c]pyrrolones, are reported. In one case the formation of a monocyclic compound was observed in varying amounts depending on the reaction atmosphere.
Synthesis of nano-sized barium ferrite particles using an inorganic dispersing phase (1993)

Nano-sized barium ferrite powders were successfully synthesized at temperatures below 600 °C without melting in a 0.313 BaO-0.258 B2O3-0.100, Na2O-0.330 Fe2O3 system, from an aqueous solution of corresponding salts. The change in crystallization behavior with varying decomposition conditions, and resultant magnetic properties were analyzed using x-ray diffraction, TEM, and vibrating-sample magnetometry, respectively. The defects which acted as nucleation sites for heterogeneous crystallization originated from decomposable constituents remaining up to the crystallization temperature. These defects were eliminated by spray drying and proper oxidation of the starting mixture before crystallization. Barium ferrite powders, having average particle size of 50–70 nm, showed a saturation magnetization (MS) of 38.37 emu/g, coercivity (HC) 2.9 kOe, and a squareness of 0.528.
A fully integrated 2.7 V 0.35 μm CMOS VCO for 5 GHz wireless applications (2002)

The wireless market drives the integration of RF circuits on common digital CMOS technologies. Full integration of the tank circuit, low-phase noise and high current efficiency are desirable for voltage-controlled oscillator (VCO) circuits. The design of fully-integrated non-relaxation VCOs in modern digital technologies is limited by the lack of high-quality passive components. For example, the quality of on-chip inductors is severely limited due to ohmic losses, especially in common CMOS technologies with low-resistivity substrates. Using transistor parasitics as tank capacitors, large active devices can be used in the VCO so current efficiency is optimized while phase-noise performance and a high center frequency are maintained. For a 0.7-2.7 V tune voltage range, a 200 MHz or 4.3% tuning range is available. This VCO can be used for 5 GHz wireless applications with a typical IF frequency of several hundred MHz.
Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements (2007)

Immunotherapies for various neurodegenerative diseases have recently emerged as a promising approach for clearing pathological protein conformers in these disorders. This type of treatment has not been assessed in models that develop neuronal tau aggregates as observed in frontotemporal dementia and Alzheimer's disease. Here, we present that active immunization with a phosphorylated tau epitope, in P301L tangle model mice, reduces aggregated tau in the brain and slows progression of the tangle-related behavioral phenotype. Females had more tau pathology than males but were also more receptive to the immunotherapy. The tau antibodies generated in these animals recognized pathological tau on brain sections. Performance on behavioral assays that require extensive motor coordination correlated with tau pathology in corresponding brain areas, and antibody levels against the immunogen correlated inversely with tau pathology. Interestingly, age-dependent autoantibodies that recognized recombinant tau protein but not the immunogen were detected in the P301L mice. To confirm that anti-tau antibodies could enter the brain and bind to pathological tau, FITC-tagged antibodies purified from a P301L mouse, with a high antibody titer against the immunogen, were injected into the carotid artery of P301L mice. These antibodies were subsequently detected within the brain and colocalized with PHF1 and MC1 antibodies that recognize pathological tau. Currently, no treatment is available for clearing tau aggregates. Our present findings may lead to a novel therapy targeting one of the major hallmarks of Alzheimer's disease and frontotemporal dementia.
Comprehensive Comparison of Auxin-Regulated and Brassinosteroid-Regulated Genes in Arabidopsis (2004)

Although numerous physiological studies have addressed the interactions between brassinosteroids and auxins, little is known about the underlying molecular mechanisms. Using an Affymetrix GeneChip representing approximately 8,300 Arabidopsis genes, we studied comprehensive transcript profiles over 24 h in response to indole-3-acetic acid (IAA) and brassinolide (BL). We identified 409 genes as BL inducible, 276 genes as IAA inducible, and 637 genes in total. These two hormones regulated only 48 genes in common, suggesting that most of the actions of each hormone are mediated by gene expression that is unique to each. IAA-up-regulated genes were enriched in genes regulated in common. They were induced quickly by IAA and more slowly by BL, suggesting divergent physiological roles. Many were early auxin-inducible genes and their homologs, namely SAUR, GH3, and IAA. The comprehensive comparison also identified IAA- and BL-specific genes, which should help to elucidate the specific actions of each hormone. The identified genes were classified using hierarchical clustering based on the similarity of their responses to the two hormones. Gene classification also allowed us to analyze the frequency of cis-elements. The TGTCTC element, a core element of the previously reported auxin response element, was not enriched in genes specifically regulated by IAA but was enriched in the 5'-flanking region of genes up-regulated by both IAA and BL. Such gene classification should be useful for predicting the functions of unknown genes, to understand the roles of these two hormones, and the promoter analysis should provide insight into the interaction of transcriptional regulation by the two hormones.
<i>meso</i> Epoxides in Asymmetric Synthesis: Enantioselective Opening by Nucleophiles in the Presence of Chiral Lewis Acids (1992)

The metal center coordinates to the epoxide oxygen atom, and the chiral ligand environment enables a nucleophile to discriminate between the formally enantiotopic carbon–oxygen bonds. The method developed by W. A. Nugent functions along this principle: the reaction of a range of meso epoxides with tri-alkylsilyl azides can be catalyzed by a new chiral Lewis acid derived from zirconium and gives β-azido alcohols in very good enantiomeric excesses. Nu = N3, R1R2 = CH3, (CH2)4, etc.
Characterization and Mapping of Melatonin Receptors in the Brain of Three Mammalian Species: Rabbit, Horse and Sheep (1991)

Melatonin receptors were characterized in the brains of three mammals (rabbit, horse and sheep) by an in vitro binding technique, using 2-[125I]iodomelatonin as labelled ligand. Although binding sites for melatonin have been described recently in several vertebrate species (including the sheep), the rabbit and the horse have not been the subject of investigation so far. Apart from characterization, the present report describes receptor distribution in a number of brain regions, thus allowing for direct interspecies comparison under the same methodological conditions. 2-[125I]iodomelatonin labelled high-affinity binding sites in crude membrane preparations from these species. A series of kinetic and saturation experiments revealed that the binding was rapid, stable, saturable, reversible, of high affinity (Kd in the low picomolar range) and low capacity (Bmax between 1 and 20 fmol/mg protein). The competition studies showed that the relative order of potency of a variety of indoles for inhibition of 2-[125I]iodomelatonin binding was as follows: 2-iodomelatonin greater than 6-chloromelatonin greater than melatonin much much greater than 5-methoxytryptophol greater than 5-methoxytryptamine, and that it was similar in the different brain regions. Prazosin, which has been reported as an extremely potent melatonin analog in the hamster brain, possessed no potency in all preparations from different regions in the three species under investigation. The regional distribution of the receptor showed insignificant species differences. Highest density was always recorded in the median eminence/pars tuberalis (ME/PT) area. Other regions (SCN, POA and certain cortical areas), showed lower, but significant, receptor content. Saturation and competition studies revealed that these binding sites were also of high affinity, low capacity and high specificity.(ABSTRACT TRUNCATED AT 250 WORDS)
Prodromal myeloproliferative neoplasms: The 2008 WHO classification (2009)

The concept of prodromal chronic myeloproliferative neoplasms has been endorsed by the WHO classification implicating a stepwise evolution of disease. Histology of the bone marrow (BM) and borderline to mildly expressed clinical features play a pivotal role for diagnosing prefibrotic-early primary myelofibrosis. By lowering the platelet count for essential thrombocythemia and regarding BM morphology, early manifestations are tackled. Pre-polycythemic stages of polycythemia vera with a low hemoglobin level at onset are diagnosed by positive JAK2V617F mutation status, a low erythropoietin value, and characteristic BM features. The revised WHO classification incorporates hematological, morphological, and molecular-genetic parameters to generate a consensus-based working diagnosis.
Edge dislocations of colloidal chains suspended in a nematic liquid crystal (2001)

We report on the formation of edge dislocations in two-dimensional crystals of colloidal chains of particles suspended in a nematic solvent. The systems are obtained from a phase separation of a binary mixture composed of a polymer and a liquid crystal. The colloidal structures are governed by elastic interactions mediated by the nematic matrix. Since the latter one breaks the rotational invariance symmetry, distortions around dislocations cannot be appropriately described by existing theories. We develop a simple elastic model which accounts for this symmetry breaking to gain information on factors governing the chains interaction. We find that rotation and compression/dilatation moduli of the chains are of the same order of magnitude. We also calculate the energies of single and pairs of dislocations. The results should be relevant for other layered systems such as smectics, cholesterics and surfactant lamellar phases in the presence of an external field.
Metering the Capillary-Driven Flow of Fluids in Paper-Based Microfluidic Devices (2010)

This article describes an exceedingly simple and low-cost method for metering the capillary-driven flow rate of fluids within three-dimensional (3D) microfluidic, paper-based analytical devices (microPADs). Initial prototypes of 3D microPADs control the spatial distribution of fluids within a device, but they provide little control over how quickly (or slowly) fluids move within the device. The methods described in this article provide control over when and how quickly a fluid is distributed into detection zones. These methods are inexpensive (the metering regions are composed of paraffin wax), the devices are easy to fabricate, and they are capable of controlling the flow of fluids to detection zones with precise time delays (e.g., +/-6% of the total wicking time). We anticipate that this type of precise control over fluid distribution rates will be useful particularly for point-of-care assays that require multiple steps (where each step requires that the reagents interact for a defined period of time) or for simultaneously displaying the results of multiple different assays on a single device.
Molecular Templating of Nanoporous Ultralow Dielectric Constant (≈1.5) Organosilicates by Tailoring the Microphase Separation of Triblock Copolymers (2001)

Triblock polymers, poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) (PEO-b-PPO-b-PEO), are used as molecular templates in poly(methyl silsesquioxane) (MSQ) matrixes to fabricate nanoporous organosilicates. The triblock copolymers microphase-separate into nanometer domains as the MSQ matrix becomes increasingly hydrophobic during a curing step. Extremely small pores (2−5 nm) are generated after thermally removing the template material. These materials attain ultralow dielectric constants (k ≈ 1.5) with electrical and mechanical integrity.
Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis (2015)

Progressive multiple sclerosis (MS) is a severely disabling neurological condition, and an effective treatment is urgently needed. Recently, high-dose biotin has emerged as a promising therapy for affected individuals. Initial clinical data have shown that daily doses of biotin of up to 300 mg can improve objective measures of MS-related disability. In this article, we review the biology of biotin and explore the properties of this ubiquitous coenzyme that may explain the encouraging responses seen in patients with progressive MS. The gradual worsening of neurological disability in patients with progressive MS is caused by progressive axonal loss or damage. The triggers for axonal loss in MS likely include both inflammatory demyelination of the myelin sheath and primary neurodegeneration caused by a state of virtual hypoxia within the neuron. Accordingly, targeting both these pathological processes could be effective in the treatment of progressive MS. Biotin is an essential co-factor for five carboxylases involved in fatty acid synthesis and energy production. We hypothesize that high-dose biotin is exerting a therapeutic effect in patients with progressive MS through two different and complementary mechanisms: by promoting axonal remyelination by enhancing myelin production and by reducing axonal hypoxia through enhanced energy production. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.
Interactive object-oriented simulation of interconnected power systems using SIMULINK (2001)

An object-oriented power system simulation environment is constructed using the SIMULINK dynamic system modeling software. The environment is well suited to educational purposes, because the user interface is interactive and intuitive with a graphical, object-oriented model representation. For small system studies, a model is constructed in block diagram form with one block for each system component. For large scale simulations, the dynamics of portions of the network can be combined into collective blocks, with parameters managed as data arrays accessed indirectly using string mnemonics. The advanced numerical capabilities built into SIMULINK provide an excellent simulation engine for the nonlinear models. Offline analysis is available through the extensive capabilities of the MATLAB environment.
Adsorption of cadmium(II) from aqueous solution onto activated carbon (1997)

The adsorption isotherm of cadmium on activated carbon was measured in a batch adsorber. Effects of temperature and solution pH on the adsorption isotherm were investigated by determining the adsorption isotherm at temperatures of 10, 25, and 40°C and at initial pH values from 2 to 8. Langmuir isotherm better fitted the experimental data since the average percent deviation was lower than with the Freundlich isotherm It was noticed that the amount of Cd2+ adsorbed was reduced about 3 times by increasing the temperature from 10 to 40°C. It was found that Cd2+ was not adsorbed on activated carbon at pH of 2 or lower and that Cd2+ was precipitated out as Cd(OH)2 at pH values above 9. Maximum adsorption capacity was observed at pH of 8 and the adsorption capacity was decreased about 12 times by reducing the initial pH from 8 to 3. According to the cadmium speciation diagram the predominant species below pH of 8 is Cd2+. Thus, cadmium was adsorbed on the activated carbon surface as Cd2+. It was concluded that the adsorption capacity is a strong function of pH and temperature.
The land mobile satellite communication channel-recording, statistics, and channel model (1991)

The communication channel between the MARECS satellite at 26 degrees W and a cruising van was measured and recorded in European areas exhibiting satellite elevations from 13 to 43 degrees . Different environments and mobile antennas were tested. The results of an extensive statistical evaluation include spectra of the fading amplitude; probability density, and distribution of the received signal power; and the percentage of time for fade and nonfade periods. Based on the physical phenomena of multipath fading and signal shadowing, an analog model of the land mobile satellite channel which can readily be used for software and hardware fading simulation is developed. The most important parameter of this model is the time-share of shadowing. The Rice factor which characterizes the channel during unshadowed periods, can vary from 3.9 to 18.1 dB. Block error probability density, error gap distribution, and block error probability are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Diaphragmatic pressures: transvenous vs. direct phrenic nerve stimulation (1985)

Diaphragmatic force, determined by stimulating the phrenic nerve while simultaneously measuring the pressures in a closed respiratory system, was assessed in five anesthetized dogs over a 5-h period to evaluate the inherent variability of this technique. Transdiaphragmatic pressure (Pdi) was measured at functional residual capacity during stimulation (120 Hz, 0.2-ms duration) of one phrenic nerve by either direct phrenic nerve stimulation (DPNS) or transvenous phrenic nerve stimulation (TPNS). An analysis of variance showed no significant (P greater than 0.50) change during the 5-h period. There was a significant correlation (r = 0.94, P less than 0.001) between Pdi obtained by TPNS and that obtained by DPNS. It is concluded that either DPNS or TPNS can be used to evaluate diaphragmatic strength over a 5-h period and that TPNS can be used in lieu of DPNS.