gebhart/patrepeval huggingface dataset:
A Novel Two–Nucleotide Deletion in the Ornithine Transcarbamylase Gene Causing Fatal Hyperammonia in Early Pregnancy (1996)

Ornithine transcarbamylase (OTC) deficiency shows X-linked inheritance. Typically, symptomatic females (who constitute 15%-20% of all carriers) have markedly reduced enzyme activity and show first symptoms in late infancy or early childhood. Here we present the case of a previously asymptomatic 24-year-old woman who died of severe hyperammonemia associated with orotic aciduria but normal OTC activity in the fourth month of pregnancy. DNA analysis revealed a novel mutation in form of the deletion of two nucleotides (T892, G893) in exon 9 of the OTC gene, leading to a frame shift and an aberrant gene product. We suggest that OTC deficiency should be suspected in any patient who presents with hyperammonia in the presence of otherwise normal liver function.
Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines. (1990)

The initiation by Th cells of B cell proliferation and differentiation to produce Ig involves both cell contact- and lymphokine-mediated signals. Plasma membrane-enriched fractions from stimulated, but not unstimulated, Th cells induced Ag nonspecific and MHC unrestricted proliferation of 60 to 70% of small dense B cells. Induction of stimulatory membrane activity was inhibited by cycloheximide, and the activity was eliminated by both protease and heat treatment of membranes. Membrane-stimulated B cells did not differentiate to secrete Ig; however, addition of a lymphokine-containing supernatant from activated Th cells or the combination of IL-4 and IL-5 resulted in substantial Ig production, predominantly of the IgM, IgG1, IgA, and IgE isotypes. The quantity and isotype distribution of the antibodies secreted were similar to those produced after B cell activation by the intact Th cells and Ag. Therefore, membranes from activated Th cells in combination with lymphokines normally secreted by such cells can replace intact Th cells and provide a defined system to identify molecular events important for B cell activation.
OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen (2005)

The molecular signals that allow primed CD8 T cells to persist and be effective are particularly important during cancer growth. With response to tumor-expressed Ag following adoptive T cell transfer, we show that CD8 effector cells deficient in OX40, a TNFR family member, could not mediate short-term tumor suppression. OX40 was required at two critical stages. The first was during CD8 priming in vitro, in which APC-transmitted OX40 signals endowed the ability to survive when adoptively transferred in vivo before tumor Ag encounter. The second was during the in vivo recall response of primed CD8 T cells, the stage in which OX40 contributed to the further survival and accumulation of T cells at the tumor site. The lack of OX40 costimulation was associated with reduced levels of Bcl-x(L), and retroviral expression of Bcl-x(L) in tumor-reactive CD8 T cells conferred greatly enhanced tumor protection following adoptive transfer. These data demonstrate that OX40 and Bcl-x(L) can control survival of primed CD8 T cells and provide new insights into both regulation of CD8 immunity and control of tumors.
Phytic acid. A natural antioxidant. (1987)

The catalysis by iron of radical formation and subsequent oxidative damage has been well documented. Although many iron-chelating agents potentiate reactive oxygen formation and lipid peroxidation, phytic acid (abundant in edible legumes, cereals, and seeds) forms an iron chelate which greatly accelerates Fe2+-mediated oxygen reduction yet blocks iron-driven hydroxyl radical generation and suppresses lipid peroxidation. Furthermore, high concentrations of phytic acid prevent browning and putrefaction of various fruits and vegetables by inhibiting polyphenol oxidase. These observations indicate an important antioxidant function for phytate in seeds during dormancy and suggest that phytate may be a substitute for presently employed preservatives, many of which pose potential health hazards.
The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly (1992)

Assembly of replication-competent hepatitis B virus (HBV) nucleocapsids requires the interaction of the core protein, the P protein, and the RNA pregenome. The core protein contains an arginine-rich C-terminal domain which is dispensable for particle formation in heterologous expression systems. Using transient expression in HuH7 cells of a series of C-terminally truncated core proteins, I examined the functional role of this basic region in the context of a complete HBV genome. All variants containing at least the 144 N-terminal amino acids were assembly competent, but efficient pregenome encapsidation was observed only with variants consisting of 164 or more amino acids. These data indicate that one function of the arginine-rich region is to provide the interactions between core protein and RNA pregenome. However, in cores from the variant ending with amino acid 164, the production of complete positive-strand DNA was drastically reduced. Moreover, almost all positive-strand DNA originated from in situ priming, whereas in wild-type particles, this type of priming not supporting the formation of relaxed circular DNA (RC-DNA) accounted for about one half of the positive strands. Further C-terminal residues to position 173 restored RC-DNA formation, and the corresponding variant did not differ from the full-length core protein in all assays used. The observation that RNA encapsidation and formation of RC-DNA can be genetically separated suggests that the core protein, via its basic C-terminal region, also acts as an essential auxiliary component in HBV replication, possibly like a histone, or like a single-stranded-DNA-binding protein. In contrast to their importance for HBV replication, sequences beyond amino acid 164 were not required for the formation of enveloped virions. Since particles from variant 164 did not contain mature DNA genomes, a genome maturation signal is apparently not required for HBV nucleocapsid envelopment.
The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites (2003)

The paraxial mesoderm of the somites of the vertebrate embryo contains the precursors of the axial skeleton, skeletal muscles and dermis. The Meox1 and Meox2 homeobox genes are expressed in the somites and their derivatives during embryogenesis. Mice homozygous for a null mutation in Meox1 display relatively mild defects in sclerotome derived vertebral and rib bones, whereas absence of Meox2 function leads to defective differentiation and morphogenesis of the limb muscles. By contrast, mice carrying null mutations for both Meox genes display a dramatic and wide-ranging synthetic phenotype associated with extremely disrupted somite morphogenesis, patterning and differentiation. Mutant animals lack an axial skeleton and skeletal muscles are severely deficient. Our results demonstrate that Meox1 and Meox2 genes function together and upstream of several genetic hierarchies that are required for the development of somites. In particular, our studies place Meox gene function upstream of Pax genes in the regulation of chondrogenic and myogenic differentiation of paraxial mesoderm.
THE PREPARATION OF A CRYSTALLINE gem-DITHIOL UNDER MILD CONDITIONS (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE PREPARATION OF A CRYSTALLINE gem-DITHIOL UNDER MILD CONDITIONSGlenn A. Berchtold, Ben E. Edwards, E. Campaigne, and Marvin CarmackCite this: J. Am. Chem. Soc. 1959, 81, 12, 3148Publication Date (Print):June 1, 1959Publication History Published online1 May 2002Published inissue 1 June 1959https://pubs.acs.org/doi/10.1021/ja01521a059https://doi.org/10.1021/ja01521a059research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Function and Regulation of Phase-Separated Biological Condensates (2018)

Achieving functional specificity while minimizing cost to fitness is a key constraint during evolution. Formation of biological condensates by liquid-liquid phase separation (LLPS) appears to serve as an important regulatory mechanism to generate moderate specificity in molecular recognition while maintaining a reasonable cost for fitness in terms of design complexity. Formation of biological condensates serves as a unique mechanism of molecular recognition achieving some level of specificity without a huge cost to fitness. Rapid formation of biological condensates in vivo induced by specific cellular or environmental triggers has been shown to be an important mechanism for increasing cellular fitness. Here we discuss the functions and regulation of biological condensates, especially those formed by LLPS, involving interactions between proteins and nucleic acids. These condensates are spatially isolated within the cytosol or nucleus and can facilitate specific biochemical functions under conditions such as stress. The misregulation of biological condensates resulting in nondynamic aggregates has been implicated in a number of diseases. Understanding the functional importance of biological condensates and their regulation opens doors for development of therapies targeting dysfunctional biological condensates, as well as spatiotemporal engineering of functions in cells.
Social Capital in Friendship-Event Networks (2006)

In this paper, we examine a particular form of social network which we call a friendship-event network. A friendship-event network captures both the friendship relationship among a set of actors, and also the organizer and participation relationships of actors in a series of events. Within these networks, we formulate the notion of social capital based on the actor-organizer friendship relationship and the notion of benefit, based on event participation. We investigate appropriate definitions for the social capital of both a single actor and a collection of actors. We ground these definitions in a real-world example of academic collaboration networks, where the actors are researchers, the friendships are collaborations, the events are conferences, the organizers are program committee members and the participants are conference authors. We show that our definitions of capital and benefit capture interesting qualitative properties of event series. In addition, we show that social capital is a better publication predictor than publication history.
Toward a self-organizing pre-symbolic neural model representing sensorimotor primitives (2014)

The acquisition of symbolic and linguistic representations of sensorimotor behavior is a cognitive process performed by an agent when it is executing and/or observing own and others' actions. According to Piaget's theory of cognitive development, these representations develop during the sensorimotor stage and the pre-operational stage. We propose a model that relates the conceptualization of the higher-level information from visual stimuli to the development of ventral/dorsal visual streams. This model employs neural network architecture incorporating a predictive sensory module based on an RNNPB (Recurrent Neural Network with Parametric Biases) and a horizontal product model. We exemplify this model through a robot passively observing an object to learn its features and movements. During the learning process of observing sensorimotor primitives, i.e., observing a set of trajectories of arm movements and its oriented object features, the pre-symbolic representation is self-organized in the parametric units. These representational units act as bifurcation parameters, guiding the robot to recognize and predict various learned sensorimotor primitives. The pre-symbolic representation also accounts for the learning of sensorimotor primitives in a latent learning context.
Design of a 100-MHz 10-mW 3-V sample-and-hold amplifier in digital bipolar technology (1995)

This paper describes the design of an all-npn open-loop sample-and-hold amplifier intended for use at the front end of analog-to-digital converters. Configured as a quasidifferential topology, the circuit employs capacitive coupling between the input and output to achieve differential voltage swings of 3 V in a 3.3-V system. It also exploits the high speed of bipolar transistors to attain a sampling rate of 100 MHz with a power dissipation of 10 mW. A prototype fabricated in a 1.5-/spl mu/m 12-GHz digital bipolar technology exhibits harmonics 60 dB below the fundamental with a 10-MHz sinusoidal input. The hold-mode feedthrough is less than -60 dB and the droop rate is 100 /spl mu/V/ns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
BASIS OF THE PREDOMINANCE OF MALE-FEMALE ASSOCIATION IN THE DOUBLE COCOONS OF SILKWORM, BOMBYX MORI L. (1997)

International audience
Oxygen diffusion limitations in pancreatic islet culture and immunoisolation (2002)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2002.
How to make a visually realistic 3D display (1991)

What is a three-dimensional display?
Audio-to-Visual Speech Conversion Using Deep Neural Networks (2016)

We study the problem of mapping from acoustic to visual speech with the goal of generating accurate, perceptually natural speech animation automatically from an audio speech signal. We present a sliding window deep neural network that learns a mapping from a window of acoustic features to a window of visual features from a large audio-visual speech dataset. Overlapping visual predictions are averaged to generate continuous, smoothly varying speech animation. We outperform a baseline HMM inversion approach in both objective and subjective evaluations and perform a thorough analysis of our results.
Physical Unclonable Functions, FPGAs and Public-Key Crypto for IP Protection. (2007)

Children with nephrotic syndrome especially those with SRNS have lower seroprotective titers for diphtheria, tetanus, pertussis and measles, necessitating a booster dose of DPT/DT/Td and MR/MMR.
A novel 3D surface construction approach: Application to three-dimensional endoscopic data (2010)

Video-endoscopy is the standard clinical procedure for visual exploration of internal walls of hollow organs. For the bladder, the lesion diagnosis is complex because the endoscopic images are bi-dimensional and cover only small bladder areas. 3D endoscopes, based on stereoscopic active vision principles, were recently proposed and validated. This paper presents a 3D reconstruction algorithm using 2D texture images and a few 3D points located on the internal wall surfaces provided by such endoscopes. The algorithm constructs a 3D panoramic surface using the 3D reconstruction method guided by 2D image registration. We show on realistic bladder phantoms that the algorithm is able to reconstruct 3D points and surfaces with a sub-millimetre accuracy.
Conflict resolution for air traffic management: a study in multiagent hybrid systems (1998)

Air traffic management (ATM) of the future allows for the possibility of free flight, in which aircraft choose their own optimal routes, altitudes, and velocities. The safe resolution of trajectory conflicts between aircraft is necessary to the success of such a distributed control system. In this paper, we present a method to synthesize provably safe conflict resolution manoeuvres. The method models the aircraft and the manoeuvre as a hybrid control system and calculates the maximal set of safe initial conditions for each aircraft so that separation is assured in the presence of uncertainties in the actions of the other aircraft. Examples of manoeuvres using both speed and heading changes are worked out in detail.
Predicting asparaginase‐associated pancreatitis (2006)

This study emphasizes our inability to predict who will develop pancreatic toxicity from asparaginase and suggests that those at risk might have an unidentified genetic predisposition.
Opportunistic medical monitoring using bluetooth P2P networks (2008)

Remote medical monitoring with medical sensors and wireless communications has recently gained attention for the potential savings and improved quality in patient health-care. Currently, many mobile wireless medical infrastructures connect to the Internet in a point-to-point fashion, such as the cellular network. However, our research investigates new models for remote patient care that exploit P2P networking among patients and healthcare providers (nurses, doctors, emergency personnel). In this paper, we identify several medical applications based on P2P Health Networking focusing on two specific scenarios where nurses and patients are both equipped with Bluetooth devices. Nurses opportunistically collect, share and upload data in a P2P fashion. During an emergency, the nearest nurse is alerted via Bluetooth Enhanced Inquiry Response mechanism. The simulation and test-bed experimentation demonstrate that Bluetooth P2P networking is both feasible and cost-effective in remote medical monitoring.
5′-O-Methylphosphonate nucleic acids—new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes (2014)

Several oligothymidylates containing various ratios of phosphodiester and isopolar 5'-hydroxyphosphonate, 5'-O-methylphosphonate and 3'-O-methylphosphonate internucleotide linkages were examined with respect to their hybridization properties with oligoriboadenylates and their ability to induce RNA cleavage by ribonuclease H (RNase H). The results demonstrated that the increasing number of 5'-hydroxyphosphonate or 5'-O-methylphosphonate units in antisense oligonucleotides (AOs) significantly stabilizes the heteroduplexes, whereas 3'-O-methylphosphonate AOs cause strong destabilization of the heteroduplexes. Only the heteroduplexes with 5'-O-methylphosphonate units in the antisense strand exhibited a significant increase in Escherichia coli RNase H cleavage activity by up to 3-fold (depending on the ratio of phosphodiester and phosphonate linkages) in comparison with the natural heteroduplex. A similar increase in RNase H cleavage activity was also observed for heteroduplexes composed of miRNA191 and complementary AOs containing 5'-O-methylphosphonate units. We propose for this type of AOs, working via the RNase H mechanism, the abbreviation MEPNA (MEthylPhosphonate Nucleic Acid).
Synchrony dual-optic accommodating intraocular lens (2006)

The Synchrony dual-optic IOL shows promise as an option to provide accommodative function in pseudophakic patients.
Urban and agricultural impacts in the structure and diversity of tree vegetation in riparian forest (2018)

The study was conducted on the Água Turva Stream bank, in the Hydrographic Microbasin of the Jirau Alto River, in Dois Vizinhos county, Paraná state, aiming to evaluate the environmental impacts of the urban occupations and agricultural activities on the floristic composition and the phytosociological structure of the arboreal stratum of the riparian forest, to obtain information on species diversity and biological invasion, which will enable the establishment of future forest restoration programs. The data collect was realized in ten sample points demarcated along the stream, where 20 sample plots of 10.0 x 10.0 m (100.0 m2) were demarcated, 10 in each stream margin. The species were identified and evaluated regarding the following variables: the CAP (Circumference at Breast Height) and total height of all the trees with CAP ? 15.0 cm (DBH ? 4.8 cm). The vegetation structure was analyzed based on the phytosociological estimators and the indexes of diversity, equability and environmental impact index of exotic species. It was concluded that the riparian forest of the Água Turva creek is quite impacted, both in the rural and urban areas, with invasion of exotic species, mainly Hovenia dulcis (japanese grape) and Musa sp. (banana tree).
A new method to electrically determine effective MOSFET channel width (1982)

A new, easy, and accurate electrical measurement method for determining process bias of MOSFET channel width is proposed. This method is based on the linear relationship between the effective width and the channel conductance (or drain current) of a MOSFET operating in the linear region. Constant and sufficiently high gate voltages compared with the threshold voltage of the device are used in the measurement to minimize the error due to the threshold-voltage variation with W in narrow-width devices. The validity of the method is supported by identical results obtained using different gate voltages.
In 2014, can we do better than CA125 in the early detection of ovarian cancer? (2014)

of patient specimens, integration of high throughput screening, and use of molecular heterogeneity in biomarker discovery, we are poised to make progress in ovarian cancer screening. This review will summarize current biomarkers, imaging, and multimodality screening strategies in the context of emerging technologies.
Imidazolium-containing, hydrophobic–ionic–hydrophilic ABC triblock copolymers: synthesis, ordered phase-separation, and supported membrane fabrication (2013)

Novel ABC triblock copolymers containing hydrophobic, imidazolium ionic liquid (IL)-based ionic, and non-charged hydrophilic blocks were synthesized by direct sequential, ring-opening metathesis polymerization (ROMP) of three chemically immiscible norborene monomers. The resulting ABC triblock copolymers were found by small-angle X-ray scattering to phase-separate into different nanostructures in their pure melt states, depending on their block sequence and compositions. Supported composite membranes of these triblock copolymers were successfully fabricated with defect-free, ≤20 microns thick top coatings. Preliminary CO2/light gas transport studies demonstrated the potential of this new type of IL-based block copolymer material for gas separation applications.