gebhart/patrepeval huggingface dataset:
Biologically oriented organic sulfur chemistry. 8. Structure-activity relations of penicillamine analogs and derivatives (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiologically oriented organic sulfur chemistry. 8. Structure-activity relations of penicillamine analogs and derivativesL. Field, B. J. Sweetman, M. M. Vestling, S. T. Ticaric, P. L. Kelly, P. Merryman, and I. A. JaffeCite this: J. Med. Chem. 1971, 14, 9, 868–872Publication Date (Print):September 1, 1971Publication History Published online1 May 2002Published inissue 1 September 1971https://pubs.acs.org/doi/10.1021/jm00291a024https://doi.org/10.1021/jm00291a024research-articleACS PublicationsRequest reuse permissionsArticle Views274Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Suppression of non-small cell lung tumor development by the <i>let-7</i> microRNA family (2008)

Many microRNAs (miRNAs) target mRNAs involved in processes aberrant in tumorigenesis, such as proliferation, survival, and differentiation. In particular, the let-7 miRNA family has been proposed to function in tumor suppression, because reduced expression of let-7 family members is common in non-small cell lung cancer (NSCLC). Here, we show that let-7 functionally inhibits non-small cell tumor development. Ectopic expression of let-7g in K-Ras(G12D)-expressing murine lung cancer cells induced both cell cycle arrest and cell death. In tumor xenografts, we observed significant growth reduction of both murine and human non-small cell lung tumors when overexpression of let-7g was induced from lentiviral vectors. In let-7g expressing tumors, reductions in Ras family and HMGA2 protein levels were detected. Importantly, let-7g-mediated tumor suppression was more potent in lung cancer cell lines harboring oncogenic K-Ras mutations than in lines with other mutations. Ectopic expression of K-Ras(G12D) largely rescued let-7g mediated tumor suppression, whereas ectopic expression of HMGA2 was less effective. Finally, in an autochthonous model of NSCLC in the mouse, let-7g expression substantially reduced lung tumor burden.
Usage of Multi-Axis Fiber Grating Strain Sensors to Support Nondestructive Evaluation of Composite Parts and Adhesive Bond Lines (2003)

Abstract : By writing fiber gratings into birefringence polarization preserving optical fiber two and three dimensional strain may be measured. It has been demonstrated that these multi-axis fiber grating strain sensors may be used to measure shear strain and transverse strain gradients. This paper will overview the usage of these sensors to perform nondestructive evaluation of adhesive joints and composite parts.
Theoretical design of surface-mounted permanent magnet motors with field- weakening capability (2002)

This master thesis deals with the design of an permanent magnet (PM) motor for electric vehicles. An analytical model for surface mounted PM-motors (SMPM) is derived and verified with finite element analysis (FEM). Special attention is paid to the iron losses as they influence the performances. Today's motors for traction in electric vehicles are most often induction motors. In recent years, PM-motors have become interesting, as the efficiency can be increased. This is very important in battery applications. The first part of the project consisted of a literature study that aimed at building knowledge on machine design for field weakening applications. An analytical model for SPM-motors was deduced thereupon. An analytical model for the design of SMPM-motors was implemented in Matlab. It was verified with two-dimensional FEM calculations (Flux2D). It was noticed, that an optimal analytical design tool requires good means for predicting the iron losses. This is due to the fact that the iron losses form a significant fraction of the total losses in SMPMmotors and therefore have a big influence on the performances. Based on the results from the FEM analysis, an iron loss model for the stator teeth and the stator yoke was derived. This iron loss model is based on the description of the flux created by the magnets and the currents in the respective areas. The influence of the stator leakage is included as well. The iron loss model covers the complete operational range. An improved model attempting to include the leakage flux was also derived. Based on the computer program, some designs and the influence of certain parameters as the number of poles or the airgap length are discussed. The design that uses the stator of the induction motor that shall be replaced is of special interest. In addition, a compact design is presented.
Discordance of Serum and Tissue Somatomedin Levels in Growth Hormone-Stimulated Growth in the Rat* (1988)

Although the somatomedins are believed to mediate GH-induced somatic growth, circulating levels of insulin-like growth factor I (IGF-I) do not always correlate with growth rate. To evaluate a paracrine or autocrine effect that might explain this discordance, the concentrations of plasma and tissue IGF-I were compared with indices of growth in hypophysectomized rats treated with rat GH (rGH). The rats received a total of 250 micrograms rGH by either continuous pump infusion (P) or twice daily injections (I). After 4 days of treatment, the amounts of IGF-I present in acetic acid extracts of liver and kidney and in native serum were determined by RIA and related to proximal tibial epiphyseal plate width. Tibial epiphyseal plate width increased from 198 +/- 6 microns (mean +/- SE) in untreated controls to 339 +/- 13 microns in group P and 347 +/- 9 micron in group I; weight gain was 11.6 +/- 1.0 g in group P and 9.6 +/- 0.8 g in group I, while control animals lost 1.0 g. Serum concentrations of IGF-I were no different between control animals and those in the injection group (0.91 +/- 0.06 vs. 0.90 +/- 0.06 U/ml), whereas levels in the infusion group increased slightly (1.1 +/- 0.05 U/ml). In contrast, rGH administration caused tissue IGF-I to double in liver (control, 0.24 +/- 0.04 U/g; P, 0.51 +/- 0.03 U/g; I, 0.46 +/- 0.05 U/g) and nearly triple in kidney (control, 0.52 +/- 0.05 U/g; P, 1.51 +/- 0.09 U/g; I, 1.36 +/- 0.08 U/g). There was no detectable change in somatomedin-binding protein by gel exclusion chromatography. Since the rGH administered was sufficient to stimulate growth and increase tissue somatomedin levels without corresponding increases in circulating IGF-I, an autocrine or paracrine action of IGF-I appears to mediate GH's initial somatogenic actions in the young rat.
Antigen-antibody interaction. Synthetic peptides define linear antigenic determinants recognized by monoclonal antibodies directed to the cytoplasmic carboxyl terminus of rhodopsin. (1988)

The specificities of four monoclonal antibodies rho 1D4, 1C5, 3A6, and 3D6 prepared by immunization of rod outer segments containing rhodopsin have been defined using synthetic peptides. All of these antibodies interact within the 18 residues at the COOH terminus of rhodopsin and recognize linear antigenic determinants of 4-11 residues. Twenty-seven synthetic peptide analogs of varying lengths of native sequence or containing single amino acid substitutions at each position of the COOH-terminal 18 residues have provided some insight into the mechanism of antigen-antibody binding. Our results clearly demonstrate that antibodies can be highly specific at key positions as shown by the loss of binding on single amino acid substitutions in the binding site. In contrast single amino acid substitutions at other positions in the binding site only affect affinity for some antibodies. Ionic interactions can dominate immunogenic determinants. Immunogenic determinants are not restricted to highly charged hydrophilic regions on the surface of a protein and may be dominated by hydrophobic interactions. Although certain side chains can dominate the interaction of the antigen with antibody, our results are in agreement with the interpretation that the free energies of all the contact points are additive and a certain free energy must be present to achieve binding. Antibodies with different specificities directed to the same region of the protein antigen can be produced in an immune response. Peptide antigens representing regions of a protein antigen bind best to the anti-protein antibody when the sequence is shortened to contain only those residues binding to the specificity site in the antibody. Cross-reactivity between protein antigens can be explained by conservation of the critical residues in the combining site.
Data Compression Book (1991)

From the Publisher:
Topics in this guide to data compression techniques include the Shannon-Fano and Huffman coding techniques, Lossy compression, the JPEG compression algorithm, and fractal compression. Readers also study adaptive Huffman coding, arithmetic coding, dictionary compression methods, and learn to write C programs for nearly any environment. The disk illustrates each learned technique and demonstrates how data compression works.
Software Support for the Yorktown Simulation Engine (1982)

The Yorktown Simulation Engine (YSE) is a special-purpose, highly-parallel programmable machine for the gate-level simulation of logic. The YSE has been designed and is being constructed at the IBM T. J. Watson Research Center. It can simulate up to one million gates at a speed of over two billion gate simulations per second; it is estimated that the IBM 3081 processor could have been simulated on the YSE at a rate of 1000 instructions per second. This is far beyond the capabilities of existing register-level software simulators. This paper describes the software support for the YSE.
The human proton-coupled folate transporter (2012)

This review summarizes the biology of the proton-coupled folate transporter (PCFT). PCFT was identified in 2006 as the primary transporter for intestinal absorption of dietary folates, as mutations in PCFT are causal in hereditary folate malabsorption (HFM) syndrome. Since 2006, there have been major advances in understanding the mechanistic roles of critical amino acids and/or domains in the PCFT protein, many of which were identified as mutated in HFM patients, and in characterizing transcriptional control of the human PCFT gene. With the recognition that PCFT is abundantly expressed in human tumors and is active at pHs characterizing the tumor microenvironment, attention turned to exploiting PCFT for delivering novel cytotoxic antifolates for solid tumors. The finding that pemetrexed is an excellent PCFT substrate explains its demonstrated clinical efficacy for mesothelioma and non-small cell lung cancer, and prompted development of more PCFT-selective tumor-targeted 6-substituted pyrrolo[2,3-d]pyrimidine antifolates that derive their cytotoxic effects by targeting de novo purine nucleotide biosynthesis.
Influence of 5,10-Methylenetetrahydrofolate Reductase Polymorphism on Whole-Blood Folate Concentrations Measured by LC-MS/MS, Microbiologic Assay, and Bio-Rad Radioassay (2007)

MTHFR C677T polymorphism influences the folate pattern in whole blood. The agreement between total folate by LC-MS/MS and microbiologic assay, independent of the MTHFR genotype, allows the use of one regression equation. Because BR results are genotype dependent, different regression equations should be used.
AUTOMOTIVE EXTERIOR LIGHTING FROM FILAMENTS TO LASERS (1999)

The evolation of optics for automobiles continues to be driven by the need for energy efficiency, automobile styling, and the introduction of new power technologies. Future optics innovations may include laser and holographic technologies.
Liquid secondary ionization mass spectrometric characterization of two synthetic phosphotyrosine-containing peptides (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid secondary ionization mass spectrometric characterization of two synthetic phosphotyrosine-containing peptidesBradford W. Gibson, Arnold M. Falick, A. L. Burlingame, Lazslo Nadasdi, Nguyen Ann Cac, and George L. KenyonCite this: J. Am. Chem. Soc. 1987, 109, 18, 5343–5348Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://pubs.acs.org/doi/10.1021/ja00252a007https://doi.org/10.1021/ja00252a007research-articleACS PublicationsRequest reuse permissionsArticle Views189Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DNA Ligands as Radioprotectors: Molecular Studies with Hoechst 33342 and Hoechst 33258 (1992)

Following earlier reports of radioprotection of cells by Hoechst 33342, we have investigated radioprotection of isolated DNA by the minor groove binders Hoechst 33258 and Hoechst 33342. Analysis of radiation-induced single strand breakage in plasmid DNA (pBR322) showed concentration-dependant protection, up to a dose-modifying factor of 9.3 for 25 microM Hoechst 33258, at which the ligand: bp ratio was 0.67. Since the ligands bind at discrete sites along DNA, sequencing gel analysis was used to investigate the radioprotective effects of the ligands both at and between the ligand-binding sites. These experiments showed that although protection was more pronounced at the binding sites, there was also some reduction in strand-breakage between binding sites. Detailed analysis at a particular site, the EcoR1 site in a 3'-32P-endlabelled 100bp restriction fragment from pBR322, showed that protection was most pronounced at the 'inner T': GAATTC. Irradiation of a synthetic oligodeoxynucleotide containing a single ligand-binding site, and labelled at the 5'-end, gave the expected doublet bands in high resolution gels, corresponding to fragments with 3'-phosphoryl- and 3'-phosphorylglycollate terminii. In the Hoechst 33258-protected sample, the 3'-phosphorylglycollate band was preferentially suppressed within the binding site. These results, together with published crystal structure data for a Hoechst 33258/dodecamer complex, suggest that the site-specific radioprotection may be due to H-atom donation from the benzimidazole NH groups in the ligand to radiation-induced radicals on 4'-deoxyribosyl carbons. In contrast to the experiments with purified DNA, in which the two ligands yielded similar results, Hoechst 33342 was a much more active radioprotector in experiments with intact cells. For 20 microM Hoechst 33342, the dose-modifying factor was 1.7 at 1% survival and 1.3 at 10% survival, whereas the same level of Hoechst 33258 yielded barely detectable protection, perhaps due to a demonstrably lower cellular uptake. Presumably the radioprotection of cells by Hoechst 33342 is due to suppression of DNA strand breakage, and further investigation of the protection mechanism(s) should enable development of improved radioprotectors.
Individual Differences in Sustained Vigilant Attention: Insights from Computational Cognitive Modeling (2008)

Sustained attention is necessary in a variety of real-world settings, from baggage screeners and air traffic controllers to lifeguards and drivers on highways. Individual differences in performance on these tasks are prevalent, leading to questions about the sources of these differences. In this paper we compare the behavior of computational models to empirical data to evaluate the validity of cognitive architectural mechanisms as explanations for individual differences in sustained vigilant attention. The models indicate that individual differences in performance on the Psychomotor Vigilance Test (PVT) are not merely the result of quantitative differences in the timing of actions, but are a consequence of differences in sensitivity to perceptual events as well, which lead to qualitative differences in how the task is performed.
The Reactions of Sulfur Trioxide, and Its Adducts, with Organic Compounds. (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reactions of Sulfur Trioxide, and Its Adducts, with Organic Compounds.Everett E. GilbertCite this: Chem. Rev. 1962, 62, 6, 549–589Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/cr60220a003https://doi.org/10.1021/cr60220a003research-articleACS PublicationsRequest reuse permissionsArticle Views3819Altmetric-Citations155LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression of the <i>Bacillus subtilis trpEDCFBA</i> Operon Is Influenced by Translational Coupling and Rho Termination Factor (2001)

The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by transcription attenuation and translational control mechanisms. Both mechanisms require binding of tryptophan-activated TRAP to 11 (G/U)AG repeats in the trp leader transcript. trpE translational control involves formation of a TRAP-dependent RNA structure that sequesters the trpE Shine-Dalgarno (SD) sequence (the SD blocking hairpin). By comparing expression levels from trpE'-'lacZ translational fusions controlled by the wild-type leader or by a leader that cannot form the SD blocking hairpin, we found that translational control requires a tryptophan concentration higher than that required for transcription attenuation. We also found that inhibition of trpE translation by the SD blocking hairpin does not alter the stability of the downstream message. Since the coding sequences for trpE and trpD overlap by 29 nucleotides, we examined expression levels from trpED'-'lacZ translational fusions to determine if these two genes are translationally coupled. We found that introduction of a UAA stop codon in trpE resulted in a substantial reduction in expression. Since expression was partially restored in the presence of a tRNA suppressor, our results indicate that trpE and trpD are translationally coupled. We determined that the coupling mechanism is TRAP independent and that formation of the SD blocking hairpin regulates trpD translation via translational coupling. We also constructed a rho mutation to investigate the role of Rho-dependent termination in trp operon expression. We found that TRAP-dependent formation of the SD blocking hairpin allows Rho access to the nascent transcript, causing transcriptional polarity.
Is Technical Analysis in the Foreign Exchange Market Profitable?: A Genetic Programming Approach (1996)

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Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-<i>N</i><sup>6</sup>-Substituted-(<i>N</i>)-Methanocarba-nucleosides as A<sub>3</sub>Adenosine Receptor Antagonists and Partial Agonists (2014)

Truncated N(6)-substituted-(N)-methanocarba-adenosine derivatives with 2-hexynyl substitution were synthesized to examine parallels with corresponding 4'-thioadenosines. Hydrophobic N(6) and/or C2 substituents were tolerated in A3AR binding, but only an unsubstituted 6-amino group with a C2-hexynyl group promoted high hA2AAR affinity. A small hydrophobic alkyl (4b and 4c) or N(6)-cycloalkyl group (4d) showed excellent binding affinity at the hA3AR and was better than an unsubstituted free amino group (4a). A3AR affinities of 3-halobenzylamine derivatives 4f-4i did not differ significantly, with Ki values of 7.8-16.0 nM. N(6)-Methyl derivative 4b (Ki = 4.9 nM) was a highly selective, low efficacy partial A3AR agonist. All compounds were screened for renoprotective effects in human TGF-β1-stimulated mProx tubular cells, a kidney fibrosis model. Most compounds strongly inhibited TGF-β1-induced collagen I upregulation, and their A3AR binding affinities were proportional to antifibrotic effects; 4b was most potent (IC50 = 0.83 μM), indicating its potential as a good therapeutic candidate for treating renal fibrosis.
Molecular nanomechanics of nascent bone: fibrillar toughening by mineralization (2007)

Mineralized collagen fibrils are highly conserved nanostructural building blocks of bone. By a combination of molecular dynamics simulation and theoretical analysis it is shown that the characteristic nanostructure of mineralized collagen fibrils is vital for its high strength and its ability to sustain large deformation, as is relevant to the physiological role of bone, creating a strong and tough material. An analysis of the molecular mechanisms of protein and mineral phases under large deformation of mineralized collagen fibrils reveals a fibrillar toughening mechanism that leads to a manifold increase of energy dissipation compared to fibrils without mineral phase. This fibrillar toughening mechanism increases the resistance to fracture by forming large local yield regions around crack-like defects, a mechanism that protects the integrity of the entire structure by allowing for localized failure. As a consequence, mineralized collagen fibrils are able to tolerate microcracks of the order of several hundred micrometres in size without causing any macroscopic failure of the tissue, which may be essential to enable bone remodelling. The analysis proves that adding nanoscopic small platelets to collagen fibrils increases their Young's modulus and yield strength as well as their fracture strength. We find that mineralized collagen fibrils have a Young's modulus of 6.23 GPa (versus 4.59 GPa for the collagen fibril), yield at a tensile strain of 6.7% (versus 5% for the collagen fibril) and feature a fracture stress of 0.6 GPa (versus 0.3 GPa for the collagen fibril).