gebhart/patrepeval huggingface dataset:
EnergySmart: Toward energy-efficient manycores for Near-Threshold Computing (2013)

While Near-Threshold Voltage Computing (NTC) is a promising approach to push back the manycore power wall, it suffers from a high sensitivity to parameter variations. One possible way to cope with variations is to use multiple on-chip voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> ) domains. However, this paper finds that such an approach is energy inefficient. Consequently, for NTC, we propose a manycore organization that has a single V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> domain and relies on multiple frequency domains to tackle variation. We call it EnergySmart. For this approach to be competitive, it has to be paired with effective core assignment strategies and also support fine-grain (i.e., short-interval) DVFS. This paper shows that, at NTC, a simple chip with a single V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> domain can deliver a higher performance per watt than one with multiple V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> domains.
Influence of Lipophilicity on the Biological Activity of Cyclic Pseudopeptide NK-2 Receptor Antagonists (1994)

A series of cyclic pseudopeptides of the formula cyclo(Leu psi[CH2NH]Xaa-Gln-Trp-Phe-beta Ala), where Xaa represents the residue of an alpha-amino acid, has been synthesized in order to establish the role of the Xaa side chain for tachykinin NK-2 receptor antagonist activity. Syntheses have been carried out in solid phase with either Fmoc or Boc strategy. The antagonist potency on NK-2 receptors in the hamster isolated trachea (HT) and the rabbit isolated pulmonary artery (RPA) bioassays increases with Xaa lipophilicity; cyclo(Leu psi[CH2NH]Cha-Gln-Trp-Phe-beta Ala) and cyclo(Leu psi[CH2NH]Asp(NHBzl)-Gln-Trp-Phe-beta Ala) resulted in being the two most active antagonists (pA2 = 9.06 and 9.26 on HT, respectively). A significant linear correlation was found between pA2 values determined in HT and RPA bioassays and capacity factors measured in reversed phase HPLC. The comparison between the biological activities of cyclic hexapeptides containing or not containing the aminomethylene moiety proved the crucial role of the pseudopeptide bond for determining high antagonist potency at the NK-2 receptor.
JETTY: filtering snoops for reduced energy consumption in SMP servers (2002)

We propose methods for reducing the energy consumed by snoop requests in snoopy bus-based symmetric multiprocessor (SMP) systems. Observing that a large fraction of snoops do not find copies in many of the other caches, we introduce JETTY, a small, cache-like structure. A JETTY is introduced in-between the bus and the L2 backside of each processor. There it filters the vast majority of snoops that would not find a locally cached copy. Energy is reduced as accesses to the much more energy demanding L2 tag arrays are decreased. No changes in the existing coherence protocol are required and no performance loss is experienced. We evaluate our method on a 4-way SMP server using a set of shared-memory applications. We demonstrate that a very small JETTY filters 74% (average) of all snoop-induced tag accesses that would miss. This results in an average energy reduction of 29% (range: 12% to 40%) measured as a fraction of the energy required by all L2 accesses (both tag and data arrays).
Magnocellular Nuclei of the Basal Forebrain: Substrates of Sleep and Arousal Regulation (1995)

Magnocellular regions of the basal forebrain (BF) are recognized as important sites of sleep-wake regulation. Evidence is reviewed for the coexistence within the BF of mechanisms that regulate neocortical and limbic system arousal along with mechanisms that promote sleep. Arousal-related functions are mediated by a system of magnocellular cholinergic neurons. BF cholinergic neurons project monosynaptically to the entire neocortex and limbic telencephalon, exert excitatory effects on target cells and participate in the regulation of activated EEG patterns characteristic of waking and REM sleep. Evidence suggests that, within the waking state, the BF cholinergic system modulates processing of sensory information in the neocortex and is involved in cognitive processes. One or more noncholinergic cell types are responsible for the sleep-promoting functions of the BF. Neurons that display elevated discharge rates during transitions from waking to sleep and during nonREM sleep have been recorded in BF sites were electrical stimulation evokes sleep and experimental lesions cause insomnia. BF neurons function to promote sleep, in part, via descending inhibition of caudal hypothalamic and brainstem activating systems. GABAergic neurons located within magnocellular regions of the BF are hypothesized to mediate sleep-promoting actions. Afferents to the BF from hypothalamic and brainstem regions are functionally important for sleep-wake regulation. Thermosensitive inputs from the anterior hypothalamus modulate the activity of BF sleep- and arousal-related cell types. Excitatory effects of brainstem inputs to BF arousal-related cells have been documented. Additional evidence supports a critical role for GABAergic-cholinergic interactions, both within the magnocellular BF and at cortical and diencephalic sites, in the regulation of behavioral state.
Mutation analysis of IL2RG in human X-linked severe combined immunodeficiency. (1997)

Severe combined immunodeficiency (SCID) is a syndrome of profoundly impaired cellular and humoral immunity. In humans, SCID is most commonly caused by mutations in the X-linked gene IL2RG, which encodes the common gamma chain, gamma c, of the leukocyte receptors for interleukin-2 and multiple other cytokines. To investigate the frequency and variety of IL2RG mutations that cause SCID, we analyzed DNA, RNA, and B-cell lines from a total of 103 unrelated SCID-affected males and their relatives using a combination of molecular and immunologic techniques. Sixty-two different mutations spanning all eight IL2RG exons were found in 87 cases, making possible correlations between mutation type and functional consequences. Although skewed maternal X chromosome inactivation, single-strand conformation polymorphism, mRNA expression, and cell surface staining with anti-gamma c antibodies were all helpful in establishing IL2RG defects as the cause of SCID, only dideoxy fingerprinting and DNA sequence determination each detected 100% of the IL2RG mutations in our series. Abnormal gamma c chains may be expressed in the lymphocytes of as many as two thirds of patients with X-linked SCID. Specific mutation diagnosis thus remains technically challenging, but it is important for genetic counseling and perhaps for helping to select appropriate subjects for retroviral gene therapy trials, This is a US government work. There are no restrictions on its use.
Amplification of femtosecond pulses at 10-kHz repetition rates in Ti:Al_2O_3 (1993)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Jeff Squier, Georg Korn, Gérard Mourou, Gary Vaillancourt, and Marcel Bouvier, "Amplification of femtosecond pulses at 10-kHz repetition rates in Ti:Al2O3," Opt. Lett. 18, 625-627 (1993) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Potentially Thrombogenic Materials in Factor IX Concentrates (1975)

Factor XI concentrates manufactured from human plasma and intended for therapeutic infsuion in man have been suspected for some time of being potentially thrombogenic. In the current studies, assays were carried out in vitro and in vivo for potentially thrombognic materials. It was possible to rank the various materials tested according to the amount of thromboninic material detected. For concentrates not containing heparin, there was substantial agreement between the in vivo and in vitro assays, with a coefficient of correlation of 0.77. There was no correlation between the assays for thrombogenicity and the antithrombin III content. We conclude that many presently availabel concentrates of Factor IX contain substantial amounts of potentially thrombogenic enzymes, and that this fact must be considered in arriving at the decision whether or not to use them therapeutically.
Crystallization and Thermal Properties (2010)

This chapter contains sections titled: Introduction Crystallinity and Crystallization Crystallization Regime Fibers Hydrolytic Degradation References
Estimation of Detection Thresholds for Redirected Walking Techniques (2009)

In immersive virtual environments (IVEs), users can control their virtual viewpoint by moving their tracked head and walking through the real world. Usually, movements in the real world are mapped one-to-one to virtual camera motions. With redirection techniques, the virtual camera is manipulated by applying gains to user motion so that the virtual world moves differently than the real world. Thus, users can walk through large-scale IVEs while physically remaining in a reasonably small workspace. In psychophysical experiments with a two-alternative forced-choice task, we have quantified how much humans can unknowingly be redirected on physical paths that are different from the visually perceived paths. We tested 12 subjects in three different experiments: (E1) discrimination between virtual and physical rotations, (E2) discrimination between virtual and physical straightforward movements, and (E3) discrimination of path curvature. In experiment E1, subjects performed rotations with different gains, and then had to choose whether the visually perceived rotation was smaller or greater than the physical rotation. In experiment E2, subjects chose whether the physical walk was shorter or longer than the visually perceived scaled travel distance. In experiment E3, subjects estimate the path curvature when walking a curved path in the real world while the visual display shows a straight path in the virtual world. Our results show that users can be turned physically about 49 percent more or 20 percent less than the perceived virtual rotation, distances can be downscaled by 14 percent and upscaled by 26 percent, and users can be redirected on a circular arc with a radius greater than 22 m while they believe that they are walking straight.
A comparison of the<i>Caulobacter</i>NA1000 and K31 genomes reveals extensive genome rearrangements and differences in metabolic potential (2014)

The genus Caulobacter is found in a variety of habitats and is known for its ability to thrive in low-nutrient conditions. K31 is a novel Caulobacter isolate that has the ability to tolerate copper and chlorophenols, and can grow at 4 ° C with a doubling time of 40 h. K31 contains a 5.5 Mb chromosome that codes for more than 5500 proteins and two large plasmids (234 and 178 kb) that code for 438 additional proteins. A comparison of the K31 and the Caulobacter crescentus NA1000 genomes revealed extensive rearrangements of gene order, suggesting that the genomes had been randomly scrambled. However, a careful analysis revealed that the distance from the origin of replication was conserved for the majority of the genes and that many of the rearrangements involved inversions that included the origin of replication. On a finer scale, numerous small indels were observed. K31 proteins involved in essential functions shared 80-95% amino acid sequence identity with their C. crescentus homologues, while other homologue pairs tended to have lower levels of identity. In addition, the K31 chromosome contains more than 1600 genes with no homologue in NA1000.
P‐41: Investigation of the Photon‐Enhanced Bias Instability of InGaZnO TFTs for the Application of Transparent AM‐OLED Displays (2010)

Abstract We investigated the effect of the light‐induced bias instability of indium‐gallium‐zinc oxide(IGZO) thin film transistors. The IGZO TFT exhibited the excellent subthreshold gate swing of 0.12V/decade, Vth of −0.5V, and high Ion/off ratio of &gt;10 9 as well as a high field‐effect mobility of 26.7 cm 2 /Vs. The Vth is not changed after positive bias illumination stress (PBIS) for 10000sec. However, the Vth is −8V after negative bias illumination stress (NBIS)for 10000sec. This phenomenon can be attributed the trapping of the photon‐induced charges into the gate dielectric/active interface. We fabricated transparent AM‐OLED driven by highly stable bottom gate IGZO TFT array
Vibration and sound (1948)

CHAPTER II THE SIMPLE OSCILLATOR 3. Free Oscillations The General Solution. Initial Conditions. Energy of Vibration 4. Damped Oscillations The General Solution. Energy Relations 5. Forced Oscillations The General Solution. Transient and Steady State. Impedance and Phase Angle. Energy Relations. Electromechanical Driving Force. Motional Impedance. Piezoelectric Crystals. 6. Response to Transient Forces Representation by Contour Integrals. Transients in a Simple System. Complex Frequencies. Calculating the Transients. Examples of the Method. The Unit Function. General Transient. Some Generalizations. Laplace Transfoms. 7. Coupled Oscillations The General Equation. Simple Harmonic Motion. Normal Modes of Vibration. Energy Relations. The Case of Small Coupling. The Case of Resonance. Transfer of Energy. Forced Vibrations. Resonance and Normal Modes. Transient Response. Problems
Ternary PtRuNi Nanocatalysts Supported on N-Doped Carbon Nanotubes: Deposition Process, Material Characterization, and Electrochemistry (2009)

Peer reviewed: Yes
Calibrating the bulk rheology of active obliquely convergent thrust belts and forearc wedges from surface profiles and velocity distributions (2000)

The geometrical profiles and surface velocity distributions in active forearc wedges depend on the bulk rheology and the surface tractions. Analytical and numerical solutions of the force balance and corner flow circulation equations indicate that the mechanical parameters should, in principle, all be directly determinable from the observational variables. The analysis suggests the following preliminary conclusions. (1) The surface profiles of forearc wedges are consistent with either a bulk plastic rheology or a viscous rheology with a transition to plastic or Coulomb behavior in the upper few kilometers. (2) Corner flow circulation in the absence of accretion is diagnostic of wedges with a bulk viscous rheology. The surface strike‐normal velocity and the surface profile both depend on the bulk viscosity and the viscous coupling at the base, allowing these mechanical variables to be determined: current estimates of this velocity in some wedges suggest the bulk viscosity is not less than 3×10 19 Pa s. (3) Obliquely converging nonaccreting plastic and Coulomb wedges show no distributed strike‐parallel shear. If the obliquity is above a critical angle, the wedge is separated from the upper plate by a strike‐slip fault, defining a forearc sliver. The critical angle of obliquity, the velocity of the forearc sliver, and the wedge geometry allow the boundary tractions to be determined. In obliquely convergent viscous wedges the strike‐parallel velocity is distributed throughout the wedge, decaying exponentially from the rear to the front. Its value at the rear and the length scale for the decay allow the bulk viscosity and the coupling at the rear to be determined. Slip vectors in some forearc wedges and thrust belts suggest complete partitioning of the strike‐parallel component of motion, characteristic of a bulk viscous rheology. Others show partitioning above a limiting angle of obliquity, suggesting bulk plastic behavior. There are no documented cases of active margins where there is an absence of partitioning for obliquity ∼45°, which appears to rule out Coulomb behavior as a general description for the bulk rheology of forearc wedges.
Solution Structures of the Linear Leaderless Bacteriocins Enterocin 7A and 7B Resemble Carnocyclin A, a Circular Antimicrobial Peptide (2013)

Leaderless bacteriocins are a class of ribosomally synthesized antimicrobial peptides that are produced by certain Gram-positive bacteria without an N-terminal leader section. These bacteriocins are of great interest due to their potent inhibition of many Gram-positive organisms, including food-borne pathogens such as Listeria and Clostridium spp. We now report the NMR solution structures of enterocins 7A and 7B, leaderless bacteriocins recently isolated from Enterococcus faecalis 710C. These are the first three-dimensional structures to be reported for bacteriocins of this class. Unlike most other linear Gram-positive bacteriocins, enterocins 7A and 7B are highly structured in aqueous conditions. Both peptides are primarily α-helical, adopting a similar overall fold. The structures can be divided into three separate α-helical regions: the N- and C-termini are both α-helical, separated by a central kinked α-helix. The overall structures bear an unexpected resemblance to carnocyclin A, a 60-residue peptide that is cyclized via an amide bond between the C- and N-termini and has a saposin fold. Because of synergism observed for other two-peptide leaderless bacteriocins, it was of interest to probe possible binding interactions between enterocins 7A and 7B. However, despite synergistic activity observed between these peptides, no significant binding interaction was observed based on NMR and isothermal calorimetry.
Raft-targeting and Oligomerization of Parasporin-2, a Bacillus thuringiensis Crystal Protein with Anti-Tumour Activity (2007)

Parasporin-2 is a newly classified Bacillus thuringiensis crystal toxin with strong cytocidal activities toward human liver and colon cancer cells. Similar to other insecticidal B. thuringiensis crystal toxins, parasporin-2 shows target specificity and damages the cellular membrane. However, the mode of parasporin-2 actions toward the cell membrane remains unknown. Here, we show that this anti-tumour crystal toxin targets lipid rafts and assembles into oligomeric complexes in the membrane of human hepatocyte cancer (HepG2) cells. Upon incubation with HepG2 cells, peripheral membrane-bound toxins, which were recovered in a low-density detergent-resistant membrane fraction, i.e. with lipid rafts, were transformed into heat-stable SDS-resistant membrane-embedded oligomers (approximately 200 kDa). The toxin oligomerization was dependent on temperature and coupled with cell lysis. The toxin oligomerization also occurred in a cell-free membrane system and was required for binding to membrane proteins, the lipid bilayer and cholesterols. These results indicate that parasporin-2 is an oligomerizing and pore-forming toxin that accumulates in lipid rafts.
Superconducting joints formed between powder-in-tube Bi/sub 2/Sr/sub 2/Ca/sub 2/Cu/sub 3/O/sub z//Ag tapes (1993)

Superconducting joints between Ag-clad, Bi/sub 2/Sr/sub 2/Ca/sub 2/Cu/sub 3/O/sub z/ tapes have been obtained with approximately 1/2 the current capacity of the tapes themselves. The Ag sheath is removed from one side of each tape without significantly disturbing the superconducting core. The exposed superconducting core of the two tapes is brought into contact and pressed so as to again seal the superconductor in a Ag sheath. A reaction anneal is performed to join the two cores together and repair damage associated with the removal of Ag and the pressing. Transport measurements using multiple voltage taps have been found useful in characterizing the critical current variation across the joint.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
RC-load analysis of the downconversion mixer IIP2 (2006)

This paper describes a theoretical study of tunable RC-loads effect on the IIP2 in a Gilbert cell type of downconversion mixer. The analysis shows how the IIP2 depends both on the load resistor and capacitor mismatch. In addition, also measurement results for this type of mixer are given to support the analysis.
Ruthenium Formyl Complexes as the Branch Point in Two- and Multi-Electron Reductions of CO2 (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRuthenium Formyl Complexes as the Branch Point in Two- and Multi-Electron Reductions of CO2Kiyotsuna Toyohara, Hirotaka Nagao, Tetsunori Mizukawa, and Koji TanakaCite this: Inorg. Chem. 1995, 34, 22, 5399–5400Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/ic00126a003https://doi.org/10.1021/ic00126a003research-articleACS PublicationsRequest reuse permissionsArticle Views725Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PREDITOR: a web server for predicting protein torsion angle restraints (2006)

Every year between 500 and 1000 peptide and protein structures are determined by NMR and deposited into the Protein Data Bank. However, the process of NMR structure determination continues to be a manually intensive and time-consuming task. One of the most tedious and error-prone aspects of this process involves the determination of torsion angle restraints including phi, psi, omega and chi angles. Most methods require many days of additional experiments, painstaking measurements or complex calculations. Here we wish to describe a web server, called PREDITOR, which greatly accelerates and simplifies this task. PREDITOR accepts sequence and/or chemical shift data as input and generates torsion angle predictions (with predicted errors) for phi, psi, omega and chi-1 angles. PREDITOR combines sequence alignment methods with advanced chemical shift analysis techniques to generate its torsion angle predictions. The method is fast (<40 s per protein) and accurate, with 88% of phi/psi predictions being within 30 degrees of the correct values, 84% of chi-1 predictions being correct and 99.97% of omega angles being correct. PREDITOR is 35 times faster and up to 20% more accurate than any existing method. PREDITOR also provides accurate assessments of the torsion angle errors so that the torsion angle constraints can be readily fed into standard structure refinement programs, such as CNS, XPLOR, AMBER and CYANA. Other unique features to PREDITOR include dihedral angle prediction via PDB structure mapping, automated chemical shift re-referencing (to improve accuracy), prediction of proline cis/trans states and a simple user interface. The PREDITOR website is located at: http://wishart.biology.ualberta.ca/preditor.