gebhart/patrepeval huggingface dataset:
Displacement‐encoded cardiac MRI using cosine and sine modulation to eliminate (CANSEL) artifact‐generating echoes (2004)

Displacement-encoded imaging with stimulated echoes (DENSE) and harmonic phase imaging (HARP) employ 1-1 spatial modulation of magnetization to cosine modulate the longitudinal magnetization as a function of position at end diastole. Later in the cardiac cycle they sample the cosine-modulated signal and compute myocardial strain from the signal phase. The sampled signal generally includes three distinct echoes: 1) a displacement-encoded stimulated echo, 2) the complex conjugate of the displacement-encoded echo, and 3) an echo arising from T1 relaxation. If the T1-relaxation and complex conjugate echoes are suppressed, then a phase image representing just the displacement-encoded echo can be reconstructed. In the present study, the use of cosine and sine modulation to eliminate (CANSEL) the T1-relaxation and complex conjugate echoes was investigated. With the use of CANSEL, it was demonstrated that DENSE accurately measures through-plane as well as in-plane components of tissue motion. Also, DENSE with CANSEL artifact suppression can provide increased signal-to-noise ratio (SNR) secondary to reduced intravoxel dephasing by using relatively low displacement-encoding frequencies. For applications that employ DENSE imaging with multiple acquisitions, the CANSEL technique can suppress artifact-generating echoes without placing constraints on the displacement-encoding frequency and direction.
Hybrid prospective and retrospective head motion correction to mitigate cross‐calibration errors (2011)

Utilization of external motion tracking devices is an emerging technology in head motion correction for MRI. However, cross-calibration between the reference frames of the external tracking device and the MRI scanner can be tedious and remains a challenge in practical applications. In this study, we present two hybrid methods, both of which combine prospective, optical-based motion correction with retrospective entropy-based autofocusing to remove residual motion artifacts. Our results revealed that in the presence of cross-calibration errors between the optical tracking device and the MR scanner, application of retrospective correction on prospectively corrected data significantly improves image quality. As a result of this hybrid prospective and retrospective motion correction approach, the requirement for a high-quality calibration scan can be significantly relaxed, even to the extent that it is possible to perform external prospective motion tracking without any prior cross-calibration step if a crude approximation of cross-calibration matrix exists. Moreover, the motion tracking system, which is used to reduce the dimensionality of the autofocusing problem, benefits the retrospective approach at the same time.
Latchup effect in CMOS IC: a solution for crypto-processors protection against fault injection attacks? (2007)

Latchup is a short-circuit that can be triggered in CMOS ICs when a current pulse is produced by parasitic perturbations. It is usually regarded as very disturbing for reliability, especially in space applications where it is triggered by ionizing particles naturally present in the environment. But in another context, the one of crypto-processors, it could be used as a way to protect the device from attacks by fault injections. Indeed, if all the parts of the ICs containing the secret data have the property to be more sensitive to latchup than to upsets, it will be impossible for attackers to retrieve the key with fault injections attacks. This paper describes how to design a crypto- processor with such features, and how to verify its properties.
Adverse effects of low concentrations of dietary RNA addition on the growth, food intake and kidney weight of young chickens (1994)

1. The effects of 0, 10 and 50 g/kg of RNA in diets on the growth and food intake of chicks from 6 to 21 d of age were examined. Their effects on renal tissue were examined by light microscopy at the end of experiment. 2. Total food intake and growth decreased with the increase in dietary RNA content and kidney weight was significantly increased by 50 g/kg RNA addition. A significant increase in liver weight was also observed in chickens fed on the diet-supplemented with 10 g RNA/kg. 3. The enlarged kidney caused by dietary RNA contained many crystals which were composed mainly of calcium salts but did not contain purines. 4. It is concluded that relatively low dietary RNA concentrations decrease food intake and growth and cause enlarged kidneys which contains many crystals composed mainly of calcium salts.
Human melanoma cell lines differ in their capacity to release ADP and aggregate platelets (1994)

In this study we have investigated, using three different human melanoma cell lines (M1Do., M3Da., M4Be.). the varying capacity of melanoma cells to induce platelet aggregation in the presence or absence of inhibitors of ADP or thrombin. The expression levels of different integrins (alpha v, beta 3, alpha v beta 3, alpha IIb, alpha v beta 3) were evaluated by immunoprecipitation, binding and flow cytometry studies. The level of ADP in supernatants of melanoma cells were quantified by ADP bioassay and HPLC. Platelets were irreversibly aggregated by M3Da, as shown by electron microscopy, in contrast to M1Do, which induced a slow reversible aggregation. M4Be. did not induce platelet aggregation. In both cases, with M3Da. or M1Do., apyrase but not PPACK inhibited platelet induced aggregation. An anti-alpha v beta 3 monoclonal antibody (LYP18) or polyclonal antibody inhibited platelet aggregation. A similar number of LYP18 molecules bound to the surface of M1Do., M3Da. and M4Be. cell lines. Biological HPLC assays of ADP present in the supernatant of tumour cell lines showed the highest concentration of ADP to be secreted by M3Da., followed by M1Do., and none detected for M4Be. These results show that differences in in vitro aggregating potential of the three human melanoma cell lines are not related to low integrin expression levels but to their ability to generate ADP. Generation of ADP by human melanoma cells may act as important modulator of melanoma-platelet interactions.
Context-Aware Time Series Anomaly Detection for Complex Systems (2013)

Systems with several components interacting to accomplish challenging tasks are ubiquitous; examples include large server clusters providing “cloud computing”, manufacturing plants, automobiles, etc. Our relentless efforts to improve the capabilities of these systems inevitably increase their complexity as we add more components or introduce more dependencies between existing ones. To tackle this surge in distributed system complexity, system operators collect continuous monitoring data from various sources including hardware and software-based sensors. A large amount of this data is either in the form of time-series or contained in logs, e.g., operators’ activity, system event, and error logs, etc. In this paper, we propose a framework for mining system operational intelligence from massive amount of monitoring data that combines the time series data with information extracted from text-based logs. Our work is aimed at systems where logs capture the context of a system’s operations and the time-series data record the state of different components. This category includes a wide variety of systems including IT systems (compute clouds, web services’ infrastructure, enterprise computing infrastructure, etc.) and complex physical systems such as manufacturing plants. We instantiate our framework for Hadoop. Our preliminary results using both real and synthetic datasets show that the proposed context-aware approach is more effective for detecting anomalies compared to a time series only approach.
Genetic cancer risk assessment (1999)

Dramatic advances in our understanding of the genetic basis for cancer have led to the development of new technologies and tools for genetic cancer risk assessment. Yet, cancer is a complex disorder, and risk assessment, counseling, and management strategies need to consider several important domains: state of cancer genetics knowledge, state of mind (previous cancer experience within the family), state of technology, and state of the art in terms of management. There are several barriers to the efficient identification and counseling of patients and families at high risk for cancer because of inherited susceptibility mutations. Chief among these concerns is the lack of access to competent counseling and education services that are equipped to handle the complex and rapidly evolving medical, technological, and ethical issues. Cancer risk assessment is developing into a distinct discipline in which established empiric risk models are recast along with rapidly evolving genetic technologies for estimation of individual cancer risk. Cancer genetics consultants are an important resource for primary care physicians, gynecologists, surgeons, and oncologists. However, no formal qualification criteria exist for either physicians or allied health care professionals who subspecialize in this new field. This article covers the unique domains of cancer genetics in health care and surveys models for delivery of cancer genetics services and tools for risk assessment. Coupled with innovative cancer diagnostic and preventive services and research, we have the potential to make great strides in cancer prevention and control.
Development of gerbil medial superior olive: integration of temporally delayed excitation and inhibition at physiological temperature (2007)

The sensitivity of medial superior olive (MSO) neurons to tens of microsecond differences in interaural temporal delay (ITD) derives in part from their membrane electrical characteristics, kinetics and timing of excitatory and inhibitory inputs, and dendrite structure. However, maturation of these physiological and structural characteristics are little studied, especially in relationship to the onset of auditory experience. We showed, using brain slices at physiological temperature, that MSO neurons exhibited sensitivity to simulated temporally delayed (TD) EPSCs (simEPSC), injected through the recording electrode, by the initial phase of hearing onset at P10, and TD sensitivity was reduced by block of low threshold potassium channels. The spike generation mechanism matured between P10 and P16 to support TD sensitivity to adult-like excitatory stimuli (1-4 ms duration) by P14. IPSP duration was shorter at physiological temperature than reported for lower temperatures, was longer than EPSP duration at young ages, but approached the duration of EPSPs by P16, when hearing thresholds neared maturity. Dendrite branching became less complex over a more restricted time frame between P10 and P12. Because many physiological and structural properties approximated mature values between P14 and P16, we studied temporal integration of simEPSCs and IPSPs at P15. Only a narrow range of relative onset times (< 1 ms) yielded responses showing sensitivity to TD. We propose that shaping of excitatory circuitry to mediate TD sensitivity can begin before airborne sound is detectable, and that inhibitory inputs having suboptimal neural delays may then be pruned by cellular mechanisms activated by sensitivity to ITD.
The Breakdown of Vigilance during Prolonged Visual Search (1948)

(1948). The breakdown of vigilance during prolonged visual search. Quarterly Journal of Experimental Psychology: Vol. 1, No. 1, pp. 6-21.
Possibilities for Recycling Cellulases After Use in Cotton Processing: Part II: Separation of Cellulases from Reaction Products and Released Dyestuffs by Ultrafiltration (2002)

The adsorption and activity of a total cellulase (Trichoderma reesei) was measured and compared on undyed and dyed cotton fabrics. Recovery of enzymes from the reaction mixture and by desorption from the cotton substrate was evaluated. About 80% of the initial protein could be recovered. The removal of released products (soluble reducing sugars and dyes) from the treatment liquor and subsequent concentration of cellulase proteins was performed using an ultrafiltration membrane. Strong protein-dye interactions made it impossible to separate efficiently the dyes from the enzyme-containing treatment liquors. The use of surfactants did not enhance cellulase desorption from cotton fabric. Although anionic surfactants have a deactivating effect on cellulases, this effect seems to be reversible, since after ultrafiltration the cellulase activity was similar to that of enzymes desorbed with buffer only. Humicola insolens cellulases were shown to be much more sensitive to anionic surfactant than T. reesei cellulases. The use of cellulases that bind reversibly to cellulose is suggested for achieving more efficient cellulase recycling and for reducing backstaining by dye-cellulase complexes.
A versatile PC-based range finding system (1991)

The authors present an active triangulation-based range finding system composed of an independent laser system generating a sheet of light projected on the object to be measured, which is placed on a linear or a rotary table driven by a personal computer. This computer includes a video digitizer board to which two cameras, looking at the scene from both sides of the sheet of light, are connected. Besides its low cost, this system has several advantages over similar systems. First of all, two cameras are used to limit the occlusion problem, and a method is proposed to integrate range data obtained from these cameras into a single range image. The calibration of each camera is very simple, provides subpixel accuracy, and is performed only once as the laser or the camera does not move. The data acquisition uses an interpolation technique that produces very accurate depth measurements. The system also provides intensity data in registration with the range data. The application of all these techniques is illustrated by showing numerous examples of the range and intensity data acquisition from various complex objects.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Wavelength-division multiplexed digital optical position transducer (1986)

A novel concept for a digital optical position transducer is presented. This compact and rugged device is electrically passive and requires only a dual-fiber optical link. Wavelength division of a broad-spectrum semiconductor light source is employed to multiplex the channels of a 10-bit digital position encoder. A preliminary design was evaluated and found to have a 10-dB on–off contrast ratio and a 12-dB insertion loss.
Carbonyl and Thiocarbonyl Compounds. V.<sup>1</sup> Synthesis of Newer Unsaturated Nitriles, Carboxylic Acids, and Esters Derived from Xanthene and Thiaxanthene (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonyl and Thiocarbonyl Compounds. V.1 Synthesis of Newer Unsaturated Nitriles, Carboxylic Acids, and Esters Derived from Xanthene and ThiaxantheneM. M. HAFEZ, N. LATIF, and I. F. ZEIDCite this: J. Org. Chem. 1961, 26, 10, 3988–3991Publication Date (Print):October 1, 1961Publication History Published online1 May 2002Published inissue 1 October 1961https://pubs.acs.org/doi/10.1021/jo01068a081https://doi.org/10.1021/jo01068a081research-articleACS PublicationsRequest reuse permissionsArticle Views332Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electrical Properties of High-Quality Stannic Oxide Crystals (1971)

Single crystals of the wide bandgap semiconductor stannic oxide, SnO2, have been grown and studied electrically. A chemical vapor deposition technique using chlorine transport, no inert carrier gases, and low pressure has been used to grow stannic oxide crystals of higher purity and with almost an order-of-magnitude higher low-temperature Hall mobility, 8800 cm2/V sec at 80°K, than have previously been available. Measurements of Hall mobility, carrier concentration, and resistivity have been made between 20 and 625°K on crystals with room-temperature carrier concentrations between 8×1015 and 2×1018 cm−3. The effects of the crystal anisotropy on these measurements have been investigated and found to be small (all results reported are for the a direction). A donor level ∼35-meV deep due to antimony and another level ascribed to oxygen vacancies at ∼140 meV have been observed. Polar optical mode scattering with a dominant characteristic temperature of 1080°C is the main carrier scattering mechanism above 250°K. Below 250°K acoustic deformation potential scattering dominates. Ionized impurity scattering is eventually important in all samples as the temperature is lowered. A polaron effective mass of 0.39 me has been found consistently in the analyses of the data. A technique of fabricating good Schottky barriers on SnO2 has also been developed and used to measure the net donor concentration in samples. The agreement found between these measurements and Nd from Hall measurements indicates that shallow trapping is not a problem in these crystals.
Focused ultrasound-mediated drug delivery through the blood–brain barrier (2015)

Despite recent advances in blood-brain barrier (BBB) research, it remains a significant hurdle for the pharmaceutical treatment of brain diseases. Focused ultrasound (FUS) is one method to transiently increase permeability of the BBB to promote drug delivery to specific brain regions. An introduction to the BBB and a brief overview of the methods, which can be used to circumvent the BBB to promote drug delivery, is provided. In particular, we discuss the advantages and limitations of FUS technology and the efficacy of FUS-mediated drug delivery in models of disease. MRI for targeting and evaluating FUS treatments, combined with administration of microbubbles, allows for transient, reproducible BBB opening. The integration of a real-time acoustic feedback controller has improved treatment safety. Successful clinical translation of FUS has the potential to transform the treatment of brain disease worldwide without requiring the development of new pharmaceutical agents.
Effect of enhanced Renilla luciferase and fluorescent protein variants on the Förster distance of Bioluminescence resonance energy transfer (BRET) (2012)

Bioluminescence resonance energy transfer (BRET) is an important tool for monitoring macromolecular interactions and is useful as a transduction technique for biosensor development. Förster distance (R(0)), the intermolecular separation characterized by 50% of the maximum possible energy transfer, is a critical BRET parameter. R(0) provides a means of linking measured changes in BRET ratio to a physical dimension scale and allows estimation of the range of distances that can be measured by any donor-acceptor pair. The sensitivity of BRET assays has recently been improved by introduction of new BRET components, RLuc2, RLuc8 and Venus with improved quantum yields, stability and brightness. We determined R(0) for BRET(1) systems incorporating novel RLuc variants RLuc2 or RLuc8, in combination with Venus, as 5.68 or 5.55 nm respectively. These values were approximately 25% higher than the R(0) of the original BRET(1) system. R(0) for BRET(2) systems combining green fluorescent proteins (GFP(2)) with RLuc2 or RLuc8 variants was 7.67 or 8.15 nm, i.e. only 2-9% greater than the original BRET(2) system despite being ~30-fold brighter.
Nerve growth factor enhances dendritic arborization of sympathetic ganglion cells in developing mammals (1988)

Recent observations have suggested that the dendritic arbors of sympathetic ganglion cells may be regulated by interactions with their peripheral targets (Voyvodic, 1987a; Yawo, 1987). In order to assess a potential mechanism for such interactions, I have investigated the effects of the target-derived trophic molecule for sympathetic ganglion cells on the development of dendrites in the rat superior cervical ganglion. Systemic treatment of neonatal animals with NGF for 1 or 2 weeks results in a striking expansion of ganglion cell dendritic arbors, as revealed by intracellular staining with HRP. During this period, neurons in treated animals extend new primary dendrites, and the length and branching of existing dendrites are increased compared to age-matched controls. These results support the idea that targets may regulate ganglion cell arbors via elaboration of NGF, and suggest an explanation for the correlation between animal size and dendritic complexity noted in several recent studies (Purves and Lichtman, 1985a; Snider, 1987; Voyvodic, 1987a).
Nitrofurazone-reducing enzymes in <i>E</i>. <i>coli</i> and their role in drug activation in vivo (1975)

Earlier work showed that Escherichia coli contains at least two enzymes which reduce nitrofurazone and other nitrofuran derivatives. One of these enzymes is lacking in some nitrofurazone-resistant mutant strains. We now report that there are three separable nitrofuran reductases in this organism: reductase I (mol. wt. ~50 000, insensitive to O 2 ), reductase IIa (mol. wt. ~120 000, inhibited by oxygen), reductase IIb (mol. wt. ~700 000, inhibited by O 2 ).Unstable metabolites formed during the reduction of nitrofurazone by preparations containing reductases IIa and IIb produce breaks in DNA in vitro. In vivo experiments with nitrofurazone-resistant strains, which lack reductase II but contain reductases IIa and IIb, demonstrated that lethality, mutation, and DNA breakage are all greatly increased when cultures are incubated under anaerobic conditions, i.e., conditions such that reductase II is active. These results provide further evidence for the importance of reductive activation of nitrofurazone.
Preliminary Investigation of Bottlenose Dolphins (<i>Tursiops truncatus</i>) for<i>hfe</i>Gene–related Hemochromatosis (2014)

Hemochromatosis (iron storage disease) has been reported in diverse mammals including bottlenose dolphins (Tursiops truncatus). The primary cause of excessive iron storage in humans is hereditary hemochromatosis. Most human hereditary hemochromatosis cases (up to 90%) are caused by a point mutation in the hfe gene, resulting in a C282Y substitution leading to iron accumulation. To evaluate the possibility of a hereditary hemochromatosis-like genetic predisposition in dolphins, we sequenced the bottlenose dolphin hfe gene, using reverse transcriptase-PCR and hfe primers designed from the dolphin genome, from liver of affected and healthy control dolphins. Sample size included two case animals and five control animals. Although isotype diversity was evident, no coding differences were identified in the hfe gene between any of the animals examined. Because our sample size was small, we cannot exclude the possibility that hemochromatosis in dolphins is due to a coding mutation in the hfe gene. Other potential causes of hemochromatosis, including mutations in different genes, diet, primary liver disease, and insulin resistance, should be evaluated.