gebhart/patrepeval huggingface dataset:
A SiGe BiCMOS Transmitter/Receiver Chipset With On-Chip SIW Antennas for Terahertz Applications (2012)

This paper presents a terahertz (THz) transmitter (Tx) and receiver (Rx) chipset operating around 400 GHz in 0.13- μm SiGe BiCMOS technology. The Tx chip consists of a voltage-controlled oscillator, a buffer, a modulator, a power amplifier, a frequency tripler, and a substrate integrated waveguide (SIW) antenna. This antenna has an additional high-pass filtering characteristic to suppress the unwanted fundamental ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) and second harmonic (2 <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) signals by 50 and 30 dB, respectively. The Rx chip includes a proposed reconfigurable SIW antenna and a novel two-mode subharmonic mixer with ~ 5-dB reduction of conversion loss. The Rx chip consumes 50 nA from a 1.2-V supply. The measurement results of the Tx and Rx chips and a back-to-back test of the Tx/Rx chipset show the feasibility and pave the way of implementing a fully integrated THz system in silicon technology for mass production.
Diazepinomicin, a New Antimicrobial Alkaloid from a Marine <i>Micromonospora</i> sp. (2004)

The structure of a new dibenzodiazepine alkaloid, diazepinomicin (1), isolated from the culture of a marine actinomycete of the genus Micromonospora was characterized using spectroscopic methods. Diazepinomicin represents a unique molecular class composed of a dibenzodiazepine core linked to a farnesyl side chain.
Retinal Blood Flow Alterations During Progression of Diabetic Retinopathy (1983)

Alterations in retinal blood flow during the progression of diabetic retinopathy were studied using the dye-dilution technique. Mean fluorescein circulation times were measured in retinal arteriovenous segments with a two-point fluorophotometer in 48 diabetic patients and 20 normal controls. Monochromatic fundus photographs were used to determine vessel diameters. Segmental blood flow (SBF) increased with the progression of background diabetic retinopathy. In patients with distinct capillary closure, SBF was significantly higher than normal values.
Real-Time Detection of Bacterial Contamination in Dynamic Aqueous Environments Using Optical Sensors (2004)

Here we describe on-line, real-time detection of waterborne bacteria using an optical sensor based on a starburst dendrimer film containing a lipophilic fluorophore. The sensor is constructed via covalent coupling between amine-terminated polyamidoamine dendrimer and silanized glass through an amide bond. The reporter molecule is embedded in the dendrimer layer through host-guest interaction. Real-time automated detection and quantitation of the bacteria are realized by using a charge-coupled detector camera and customized imaging and analysis software. The sensor responds to bacteria introduced to an aqueous flow system within 1 min. The limit of detection is approximately 10(4)cells/mL. The operational lifetime is more than 64 h, and the storage lifetime of the sensor is at least 7 months.
50nm gate length logic technology with 9-layer Cu interconnects for 90nm node SoC applications (2003)

A 90 nm generation logic technology with Cu/low-k interconnects is reported. 50 nm transistors are employed using gate oxide 1.3 nm in thickness and operating at 1.0 V. High speed transistors have drive currents of 870 /spl mu/A/pm and 360 /spl mu/A//spl mu/m for NMOS and PMOS respectively, while generic transistors have currents of 640 /spl mu/A//spl mu/m and 260 /spl mu/A//spl mu/m respectively. Low power process using high-k gate dielectrics and SOI process are also provided in this technology. The low-k SiOC material with 2.9 in the k value is used for 9 layers of dual damascene Cu/low-k interconnects. The effective k (k/sub eff/) value of interconnect is about 3.6. Fully working 6-T SRAM cell with an area of 1.1 /spl mu/m/sup 2/ and SNM value of 330 mV is obtained. For MIM capacitor, voltage coefficient of capacitance is less than 20 ppm/V.
10.51847/X86lwLD (2000)

Investigations were conducted to determine the proteolytic activity using bromocresol green dye on substrate agar plates. Two methods were highlighted in this article. The first method was adopted to determine the proteolytic activity by flooding bromocresol green reagent on casein/skimmed milk agar plates. Later, a minimum of 0.0015% of bromocresol green was incorporated with the substrate agar plates before autoclaving to detect the proteolytic activity of bacteria. The proteolytic activity ap
Letizia: an agent that assists web browsing (1995)

Letizia is a user interface agent that assists a user browsing the World Wide Web. As the user operates a conventional Web browser such as Netscape, the agent tracks user behavior and attempts to anticipate items of interest by doing concurrent, autonomous exploration of links from the user&amp;apos;s current position. The agent automates a browsing strategy consisting of a best-first search augmented by heuristics inferring user interest from browsing behavior. 1
Theoretical performance of multi-junction solar cells combining III-V and Si materials (2012)

A route to improving the overall efficiency of multi-junction solar cells employing conventional III-V and Si photovoltaic junctions is presented here. A simulation model was developed to consider the performance of several multi-junction solar cell structures in various multi-terminal configurations. For series connected, 2-terminal triple-junction solar cells, incorporating an AlGaAs top junction, a GaAs middle junction and either a Si or InGaAs bottom junction, it was found that the configuration with a Si bottom junction yielded a marginally higher one sun efficiency of 41.5% versus 41.3% for an InGaAs bottom junction. A significant efficiency gain of 1.8% over the two-terminal device can be achieved by providing an additional terminal to the Si bottom junction in a 3-junction mechanically stacked configuration. It is shown that the optimum performance can be achieved by employing a four-junction series-connected mechanically stacked device incorporating a Si subcell between top AlGaAs/GaAs and bottom In<sub>0.53</sub>Ga<sub>0.47</sub>As cells.
Hierarchical Genre Classification for Large Music Collections (2006)

The rapid progress in digital music distribution has lead to the creation of large collections of music. There is a need for content-based music classification methods to organize these collections automatically using a given genre taxonomy. To provide a versatile description of the music content, several kinds of features like rhythm, pitch or timbre characteristics are commonly used. Taking the highly dynamic nature of music into account, each of these features should be calculated up to several hundreds of times per second. Thus, a piece of music is represented by a complex object given by several large sets of feature vectors. In this paper, we propose a novel approach for the hierarchical classification of music pieces into a genre taxonomy. Our approach is able to handle multiple characteristics of music content and achieves a high classification accuracy efficiently, as shown in our experiments performed on a real world data set
Safety of Denosumab Versus Zoledronic Acid in Patients with Bone Metastases: A Meta-Analysis of Randomized Controlled Trials (2016)

Denosumab was safer in delaying or preventing skeletal-related events in patients with bone metastases and prevented pain progression compared to ZA in this meta-analysis.
Brain-specific enhancement of the mouse neurofilament heavy gene promoter in vitro. (1994)

We have investigated the DNA elements responsible for transcription from the proximal portion of the mouse neurofilament heavy gene (NF-H) promoter by in vitro transcription using extracts from expressing (brain) and non-expressing (liver) tissues. We have found that constructs containing 5' region from -1314 to -115 exhibit a 3-5-fold higher level of NF-H promoter activity, relative to the adenovirus major late promoter (pML), in brain versus liver extracts. Deletion to -85 lowers the level of brain transcription by 2-fold, while deletion from -65 through -31 reduces transcription by 5-fold to a relatively strong (10% of pML) basal level. Basal level expression is observed in all deletions transcribed with liver extract. Deletion to -24 (TATA-less) abolishes promoter activity with both extracts. Deletion of the -115 to -65 region from a larger construct reduces transcription in brain extracts to basal levels, suggesting that this region contains the elements necessary for the brain-specific enhancement of promoter function. Mutation of a palindromic sequence within this region abolishes brain-specific enhanced promoter activity. This loss of enhanced transcriptional activity is correlated with the loss of a shifted band in gel shift assays. Our studies suggest that the sequence (-106)GGGGAGGAGG-(15 bp)-CCTCCTCCCC(-72) (where bp = base pairs) is important in brain-specific enhancement of transcription from the mouse NF-H promoter.
Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation (2010)

Friedreich ataxia is a degenerative disease caused by deficiency of the protein frataxin (FXN). An intronic expansion of GAA triplets in the FXN-encoding gene, FXN, causes gene silencing and thus reduced FXN protein levels. Although it is widely assumed that GAA repeats block transcription via the assembly of an inaccessible chromatin structure marked by methylated H3K9, direct proof for this is lacking. In this study, we analysed different histone modification patterns along the human FXN gene in FRDA patient-derived lymphoblastoid cell lines. We show that FXN mRNA synthesis, but not turnover rates are affected by an expanded GAA repeat tract. Importantly, rather than preventing transcription initiation, long GAA repeat tracts affect transcription at the elongation step and this can occur independently of H3K9 methylation. Our data demonstrate that finding novel strategies to overcome the transcription elongation problem may develop into promising new treatments for FRDA.
An update of the HLA genomic region, locus information and disease associations: 2004 (2004)

The human major histocompatibility (MHC) genomic region at chromosomal position 6p21 encodes the six classical transplantation HLA genes and many other genes that have important roles in the regulation of the immune system as well as in some fundamental cellular processes. This small segment of the human genome has been associated with more than 100 diseases, including common diseases--such as diabetes, rheumatoid arthritis, psoriasis, asthma and various autoimmune disorders. The MHC 3.6 Mb genomic sequence was first reported in 1999 with the annotation of 224 gene loci. The locus and allelic information of the MHC continue to be updated by identifying newly mapped expressed genes and pseudogenes based on comparative genomics, SNP analysis and cDNA projects. Since 1999, new innovations in bioinformatics and gene-specific functional databases and studies on the MHC genes have resulted in numerous changes to gene names and better ways to update and link the MHC gene symbols, names and sequences together with function, variation and disease associations. In this study, we present a brief overview of the MHC genomic structure and the recent information that we have gathered on the MHC gene loci via LocusLink at the National Centre for Biological Information (http://www.ncbi.nih.gov/.) and the MHC genes' association with various diseases taken from publications and records in public databases, such as the Online Mendelian Inheritance in Man and the Genetic Association Database.
Role of nitric oxide in chick embryonic organogenesis and dysmorphogenesis (2007)

Our results showed that regulation of NO is essential for normal axial development, that sites of altered NO expression correlate to those of altered apoptosis and dysmorphogenesis, and that CO coadministration resulted in a rectification of normal NO expression. Collectively, these results suggest that alteration in endogenous NO/CO signaling is responsible, at least in part, for the observed NO-induced teratogenesis.
Dyskeratosis congenita: a combined immunodeficiency with broad clinical spectrum – a single‐center pediatric experience (2011)

In DKC, development of immunologic abnormalities can precede bone marrow failure, highlighting the importance of proper immunodeficiency management to minimize morbidity and premature mortality in this disease.
Oracle8 Database Design Using UML Object Modeling (1998)

From the Publisher:
The ultimate guide to designing with Oracle8 databases. A complete conceptual and practical guide to building Oracle8 Databases using UML object modeling. 
A complete conceptual and practical guide to building Oracle8 databases. 
Think about database development in a new way and build powerful relational and object-relational databases with Oracle8! With this unique guide you'll learn to use Oracle8's technology to create flexible databases that will meet the demands of today's business environment-and tomorrow's. 
Inside Oracle8 Design Using UML Object Modeling,you'll find coverage of both concepts and practical techniques. The authors demonstrate the benefits of using the Unified Modeling Language's (UML) richer and more precise way of creating sound data models. Rather than the traditional break between logical and physical models-which can lead to numerous implementation problems-the authors propose the creation of a unified model that evolves as the software-development life cycle progresses. With this book,you will: 

Design flexible databases that support a broad range of requirementsBuild a database step-by-step with efficiently running structuresLearn advanced modeling structures,such as entity/object subsets; dependent,recursive,and cyclical structures; denormalization; and generic modelingCreate standards for database design,from naming conventions and UID specifications to domains of datatypesDesign databases that easily respond to changes in system requirements,often with no developer interventionConstruct databases that combine the best aspects of traditional relational design with the cutting-edge capabilities of objectsusing this guide from two well-respected Oracle experts
Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72 (2013)

We conclude that DPR are a major component of p62 positive inclusions in FTLD and MND.
Cytometric Analysis of Cell Phenotype and Function (2001)

Flow cytometry and laser scanning cytometry are increasingly used in clinical and research settings, following improvements in instrument design and computing power and the increased availability of fluorescent agents. This book provides a comprehensive introduction to the theory and clinical applications of these techniques in the assessment of cell phenotype and function. With an emphasis on clinical relevance, the book presents the principles and potential of cytometry in the analysis of phenomena including cell-mediated cytotoxicity, metabolic burst, phagocytosis, cell-cell aggregation, receptor shedding and apoptosis. Guidance is given on data interpretation, quality control procedures, pitfalls and problems. All chapters contain detailed protocols from leading authorities in the field with extensive practical experience.
<b>Phosphonic Acid Analogs of Nucleoside Phosphates. I. The Synthesis of 5″-Adenylyl Methylenediphosphonate, a Phosphonic Acid Analog of ATP</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphonic Acid Analogs of Nucleoside Phosphates. I. The Synthesis of 5″-Adenylyl Methylenediphosphonate, a Phosphonic Acid Analog of ATPTerrell C. Myers, Kaname. Nakamura, and James W. FlesherCite this: J. Am. Chem. Soc. 1963, 85, 20, 3292–3295Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ja00903a053https://doi.org/10.1021/ja00903a053research-articleACS PublicationsRequest reuse permissionsArticle Views351Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Risk Factor Analysis for Injuries in Football Players (2000)

Review of the literature shows that information concerning risk factors for football injuries is incomplete and partly contradictory. The aim of this study was to analyze the influence of medical history, physical findings, football skills, and football performance, as well as psychosocial characteristics on the occurrence and severity of football injuries. The prospective outline of the study was as follows: after a baseline examination was performed to ascertain possible predictors of injury, all players were followed up weekly for 1 year to register subsequent injuries and complaints. Two hundred sixty-four of 398 players (67%) had complete weekly follow-ups over 1 year. A majority of the players (N = 216; 82%) were injured during the observation period. In comparing injured and uninjured players, several differences were observed. To create a multidimensional predictor score for football injuries, 17 risk factors were selected. These risk factors covered a wide spectrum, such as previous injuries, acute complaints, inadequate rehabilitation, poor health awareness, high life-event stress, playing characteristics, poor reaction time, poor endurance, and insufficient preparation for games. By summing up the individual risk factors, a predictive sum was calculated for each player. The more risk factors present at the baseline examination, the higher the probability of that player incurring an injury in the ensuing year. Using two risk factors as the cut-off score, more than 80% of the players were correctly classified as to whether they went on to incur an injury. Based on these findings, knowledge from the literature, and practical experience, possibilities for a prevention program are suggested.
Soluble Gentamicin Ophthalmic Inserts as a Drug Delivery System (1978)

A comparison was made of soluble 14C-gentamicin ophthalmic inserts with drop, ointment, and the subconjunctival routes of administration. The insert is a solid, solubilizable collagen polymer containing 14C-gentamicin. We compared the levels of 14C-gentamicin in the rabbit tear film and in multiple corneal and scleral biopsies to determine which route of administration gave the best results. The wafer route of administration gave the highest tear film and tissue concentration of drug. The tear film concentration by subconjunctival injection was surprisingly low. Soluble collagen inserts offer a new method of delivering high doses of gentamicin in infected corneal tissue in a convenient and atraumatic fashion.
Genetic Analysis of the <b> <i>RNASEL</i> </b> Gene in Hereditary, Familial, and Sporadic Prostate Cancer (2004)

Considering the high quality in genotyping and the size of this study, these results provide solid evidence against a major role of RNASEL in prostate cancer etiology in Sweden.
An ultralow-power UHF transceiver integrated in a standard digital CMOS process: architecture and receiver (2001)

A broad range of high-volume consumer applications require low-power battery-operated wireless microsystems and sensors. These systems should conciliate a sufficient battery lifetime with reduced dimensions, low cost, and versatility. Their design highlights the tradeoff between performance, lifetime, cost, and power consumption. Also, special circuit and design techniques are needed to comply with the reduced supply voltage (down to 1 V, for single battery cell operation). These considerations are illustrated by the design of a prototype receiver chip realized in a standard 0.5-/spl mu/m digital CMOS process with 0.6-V threshold voltage. The chip is dedicated to a distributed sensors network and is based on a direct-conversion architecture. The circuit operates at 1-V power supply in the 434-MHz European ISM band and consumes only 1 mW in receive mode. It achieves a -95 dBm sensitivity for a data rate of 24 kb/s.
The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapy (2016)

Bruton's tyrosine kinase (BTK) mediates B cell signaling and is also present in innate immune cells but not T cells. BTK propagates B cell receptor (BCR) responses to antigen-engagement as well as to stimulation via CD40, toll-like receptors (TLRs), Fc receptors (FCRs) and chemokine receptors. Importantly, BTK can modulate signaling, acting as a "rheostat" rather than an "on-off" switch; thus, overexpression leads to autoimmunity while decreased levels improve autoimmune disease outcomes. Autoreactive B cells depend upon BTK for survival to a greater degree than normal B cells, reflected as loss of autoantibodies with maintenance of total antibody levels when BTK is absent. This review describes contributions of BTK to immune tolerance, including studies testing BTK-inhibitors for treatment of autoimmune diseases.
Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients (2008)

In this study the prevalence of dry eye syndrome was 54.3%. Diabetes and dry eyes appear to have a common association. Further studies need to be undertaken to establish an etiologic relationship. However, examination for dry eye should be an integral part of the assessment of diabetic eye disease.
Fast 3D radiofrequency field mapping using echo‐planar imaging (2006)

An inhomogeneous radiofrequency (RF) magnetic field is an essential source of error for the quantification of MRI and MRS parameters. To correct for effects of RF inhomogeneities in 3D data sets, it is necessary to have knowledge of the 3D RF distribution in the sample. In this paper a method for fast 3D RF mapping is presented. The method is based on the simultaneous acquisition of a spin echo (SE) and a stimulated echo (STE) using echo-planar imaging (EPI). The acquisition of the 3D RF map using 64 partitions and TR = 500 ms requires 1.5 min. The use of the sequence in vivo is demonstrated by the calculation of the RF maps in the human brain at 3T. The comparison of calculated flip angles with the flip angles obtained by fitting signal behavior in the 3D stimulated-echo acquisition mode (STEAM)-EPI sequence and the analysis of errors due to spatially dependent T(1) values in the brain show that the accuracy of the calculated flip angles in the human brain is about 2 degrees.
NH2-terminal amino acid sequence of human fibroblast interferon. (1980)

The purification of human fibroblast interferon by chromatography on Blue Sepharose and high-performance liquid chromatography is described. The amino acid composition and a partial sequence of the homogeneous protein are reported. The NH2 terminus was determined to be NH2-Met1-Ser-Tyr-Asn-Leu-Leu-Gly-Phe-Leu-Gln-Arg-Ser-Ser-Asn-Phe-Gln-X-Gln-Lys.