gebhart/patrepeval huggingface dataset:
Potentiation of the somatogenic and lactogenic activity of human growth hormone with monoclonal antibodies (1986)

Monoclonal antibodies of certain epitope specificity have been shown to produce a marked dose-dependent enhancement of the somatogenic and lactogenic activity of human GH (hGH). Two antibodies (EB1 and EB2), binding to distinct antigenic determinants and expressed on both hGH and human chorionic somato-mammotrophin (hCS), significantly enhanced the hGH-stimulated uptake of 35S-labelled sulphate into cartilage. Similarly, these antibodies enhanced the lactogenic activity of both hGH and hCS in the pigeon crop sac test. Two hGH specific monoclonal antibodies (QA68 and NA71), defining a further two epitopes, exhibited only modest enhancing or inhibitory activity in these assays, whereas the binding of certain combinations of monoclonal antibodies resulted in either reversal of enhancement or inhibition of hormone activity. Univalent antibody fragments derived from EB1 were as enhancing as the intact antibody indicating that bivalency dependent mechanisms were not involved in the phenomenon. Enhancing monoclonal antibodies were relatively poor inhibitors of 125I-labelled hGH binding to liver microsomal receptors, which is in contrast with their previously described property of potent suppression of hGH interaction with lymphoid cell receptors. It is tentatively concluded that 'restriction' of hormone binding to particular hGH receptors, relevant to somatic growth or lactogenic activity, may play a role in the enhancement phenomenon of hGH in vivo.
Impaired oxidation of debrisoquine in patients with perhexiline liver injury. (1984)

Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination. Its use may be complicated by the development of peripheral neuropathy and liver damage. The majority of patients with perhexiline neuropathy have an impaired ability to effect metabolic drug oxidation which is genetically determined. Information has not been available on drug oxidation capacity in patients with perhexiline liver injury. Drug oxidation was measured using an oxidation phenotyping procedure in four patients with perhexiline liver injury and in 70 patients with chronic liver disease serving as a control group. All four patients with perhexiline liver damage showed a substantial metabolic defect; three of the four patients (75%) showed a genetically determined impairment of oxidation capacity. The incidence of severely impaired oxidation capacity in the perhexiline group was significantly greater than in the patients with chronic liver disease (6/70; 8.6%) and in the healthy population (9%) (F = 0.0048). A clear association exists between perhexiline liver injury and diminished drug metabolic activity, suggesting that the propensity to develop perhexiline liver injury is, at least in part, genetically determined.
Rendering of spherical light fields (2002)

A plenoptic function is a parameterized function describing the flow of light in space, and has served as a key idea in building some of the recent image based rendering systems. The paper presents a new representation scheme, called a spherical light field, of the plenoptic function, that is based on spheres. While methods using spherical coordinates are thought to require substantially more computation than those using planar or cylindrical coordinates, we show that spheres can also be used efficiently in representing and resampling the flow of light. Our image based rendering algorithm is different from the previous systems, the light field and lumigraph, in that it is an "object space" algorithm that can be easily embedded into the traditional polygonal rendering system. Our method is easily accelerated by 3D graphics boards that support the primitive functionality, such as viewing and smooth shading. In addition, we introduce an encoding scheme based on wavelets for compression of the huge data resulting from sampling of the spherical light field. The proposed technique can be easily adapted to compress the light field and lumigraph data, and offers as high compression ratios as the previous methods. Furthermore, it naturally creates a multi resolutional representation of the light flow that can be exploited effectively in the future applications. We show how to access the compressed data efficiently using a modified significance map and an incremental decoding technique, and report experimental results on several test data sets.
Conservation therapy for invasive lobular carcinoma of the breast (1992)

Earlier literature suggests a high incidence of multicentricity and bilaterality, with an overall poor prognosis, in patients with invasive lobular carcinoma of the breast. Consequently, there is considerable disagreement regarding appropriate local management of this disease. To determine the influence of invasive lobular histologic findings on local tumor control, disease-free survival, and overall survival, the authors reviewed 60 patients with Stage I and II invasive lobular breast carcinoma treated with local tumor excision and radiation therapy between 1981 and 1987 (mean follow-up, 5.5 years; range, 2.5 to 10 years). The 5-year actuarial risk of locoregional recurrence was 5%, with two of three failures occurring in the regional lymphatics. The mean time to locoregional failure was 28 months. The 5-year actuarial disease-free survival (84%) and overall survival (91%) were comparable to those seen in several large series of similarly treated patients with invasive ductal carcinoma. Contralateral breast cancer occurred at a rate of approximately 0.6% per year. This study and a review of the literature suggest that breast conservation, with local resection and radiation therapy, is appropriate therapy for invasive lobular breast cancer.
Cross linguistic name matching in English and Arabic (2006)

This paper presents a solution to the problem of matching personal names in English to the same names represented in Arabic script. Standard string comparison measures perform poorly on this task due to varying transliteration conventions in both languages and the fact that Arabic script does not usually represent short vowels. Significant improvement is achieved by augmenting the classic Levenshtein edit-distance algorithm with character equivalency classes.
Metabolic Engineering of <i>Escherichia coli</i> for Production of Enantiomerically Pure ( <i>R</i> )-(−)-Hydroxycarboxylic Acids (2003)

A heterologous metabolism of polyhydroxyalkanoate (PHA) biosynthesis and degradation was established in Escherichia coli by introducing the Ralstonia eutropha PHA biosynthesis operon along with the R. eutropha intracellular PHA depolymerase gene. By with this metabolically engineered E. coli, enantiomerically pure (R)-3-hydroxybutyric acid (R3HB) could be efficiently produced from glucose. By employing a two-plasmid system, developed as the PHA biosynthesis operon on a medium-copy-number plasmid and the PHA depolymerase gene on a high-copy-number plasmid, R3HB could be produced with a yield of 49.5% (85.6% of the maximum theoretical yield) from glucose. By integration of the PHA biosynthesis genes into the chromosome of E. coli and by introducing a plasmid containing the PHA depolymerase gene, R3HB could be produced without plasmid instability in the absence of antibiotics. This strategy can be used for the production of various enantiomerically pure (R)-hydroxycarboxylic acids from renewable resources.
Stability of levodopa in 5% dextrose injection at pH 5 or 6 (1986)

The stability of solutions of levodopa 1 mg/mL in 5% dextrose injection adjusted to pH 5 or 6 and stored at one of three temperatures was determined. Solutions were adjusted to pH 5 or 6 with sodium acetate injection or sodium phosphate injection, respectively. Three samples of solution adjusted to pH 5 were stored at each of three temperatures (4, 25, and 45 degrees C), and three samples of solution adjusted to pH 6 were stored at 25 degrees C. Samples were assayed for levodopa concentration by high-performance liquid chromatography at various times during the 21-day study period. All solutions maintained at least 90% of the initial concentration of levodopa for seven days. Discoloration of all solutions except those stored at 4 degrees C was noted at some point during the study period; solutions stored at 45 degrees C began to darken within 12 hours. The pH values of the solutions did not change during the study period. Under the conditions studied, solutions of levodopa 1 mg/mL in 5% dextrose injection adjusted to pH 5 or 6 are stable for seven days. Slight degradation of levodopa may cause a brownish-black discoloration of the admixtures.
2-Amino-5,6-dihydro-1,3-oxazines. The Reduction of Carboxylic Esters with Sodium Borohydride<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Amino-5,6-dihydro-1,3-oxazines. The Reduction of Carboxylic Esters with Sodium Borohydride1Joseph A. Meschino and Carol H. BondCite this: J. Org. Chem. 1963, 28, 11, 3129–3134Publication Date (Print):November 1, 1963Publication History Published online1 May 2002Published inissue 1 November 1963https://pubs.acs.org/doi/10.1021/jo01046a046https://doi.org/10.1021/jo01046a046research-articleACS PublicationsRequest reuse permissionsArticle Views368Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient top-K query calculation in distributed networks (2004)

This paper presents a new algorithm to answer top-k queries (e.g. find the k objects with the highest aggregate values) in a distributed network. Existing algorithms such as the Algorithm [10] consume an excessive amount of bandwidth when the number of nodes, m, is high. We propose a new algorithm called Three-Phase Uniform Threshold (TPUT). TPUT reduces network bandwidth consumption by pruning away ineligible objects, and terminates in three round-trips regardless of data input.The paper presents two sets of results about TPUT. First, trace-driven simulations show that, depending on the size of the network, TPUT reduces network traffic by one to two orders of magnitude compared to existing algorithms. Second, TPUT is proven to be instance-optimal on common data series. In particular, analysis shows that by using a pruning parameter α
Multi-parametric evaluation of sit-to-stand and stand-to-sit transitions in elderly people (2011)

The aim of this study was to extract multi-parametric measures characterizing different features of sit-to-stand (Si-St) and stand-to-sit (St-Si) transitions in older persons, using a single inertial sensor attached to the chest. Investigated parameters were transition's duration, range of trunk tilt, smoothness of transition pattern assessed by its fractal dimension, and trunk movement's dynamic described by local wavelet energy. A measurement protocol with a Si-St followed by a St-Si postural transition was performed by two groups of participants: the first group (N=79) included Frail Elderly subjects admitted to a post-acute rehabilitation facility and the second group (N=27) were healthy community-dwelling elderly persons. Subjects were also evaluated with Tinetti's POMA scale. Compared to Healthy Elderly persons, frail group at baseline had significantly longer Si-St (3.85±1.04 vs. 2.60±0.32, p=0.001) and St-Si (4.08±1.21 vs. 2.81±0.36, p=0.001) transition's duration. Frail older persons also had significantly decreased smoothness of Si-St transition pattern (1.36±0.07 vs. 1.21±0.05, p=0.001) and dynamic of trunk movement. Measurements after three weeks of rehabilitation in frail older persons showed that smoothness of transition pattern had the highest improvement effect size (0.4) and discriminative performance. These results demonstrate the potential interest of such parameters to distinguish older subjects with different functional and health conditions.
Tetranucleotide repeat polymorphism at the HPRT locus (1991)

Journal Article Tetranucleotide repeat polymorphism at the HPRT locus Get access C.M. Hearne, C.M. Hearne Nuffield Department of Surgery, John Radcliffe HospitalHeadington, Oxford OX3 9DU, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar J.A. Todd J.A. Todd * Nuffield Department of Surgery, John Radcliffe HospitalHeadington, Oxford OX3 9DU, UK *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 19, 11 October 1991, Page 5450, https://doi.org/10.1093/nar/19.19.5450 Published: 11 October 1991
APOPCALEAPS: Automatic Music Generation with CHRiSM (2010)

We present a new system for automatic music generation, in which music is modeled using very high level probabilistic rules. The probabilistic parameters can (at least in principle) be learned automatically from examples, resulting in a system for personalized music generation. 1
Band alignment at electrode-organic interfaces (2009)

The band alignment at metal-organic interfaces has been extensively studied; however the electrodes in real devices often consist of metals modified with dielectric buffer layers. We demonstrate that interface dipole theory, originally developed to describe Schottky contacts at metal-semiconductor interfaces, can also accurately describe the injection barriers in real organic electronic devices (i.e, at electrode-organic interface). It is found that theoretically predicted hole injection barriers for various archetype metal-organic and metal-dielectric-organic structures are in excellent agreement with values extracted from experimental measurements.
Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates (2014)

This review highlights antibiofouling polymer interfaces with emphasis on the latest developments using poly(ethylene glycol) and the design new polymeric structures.
Use of HTR synthetic bone grafts in conjunction with immediate dental implants. (2003)

Immediate placement of dental implants in fresh extraction sockets is associated with remaining voids around the implants and often a partial dehiscence or thinning of the facial alveolar plate. Nine patients had Bioplant HTR synthetic bone used as a ridge preservation/augmentation material in conjunction with immediate placement of 10 implants. Hard tissue replacement (HTR) was used to fill the remaining socket void and enhance the facial ridge width, and the wound closed as completely as possible. Dental implants were uncovered at approximately 6 months. Measurements taken of the internal socket width and total ridge width at the implant placement and uncovering showed the mean internal socket width was maintained (7.2 mm vs 6.9 mm), and the total ridge width exhibited a mean change from 9.6 mm to 8.8 mm. Of the 10 implant sites, 7 showed a net increase, 2 no change, and 1 a decrease in overall ridge width. All 10 implants were restored for at least 6 months. These clinical results suggest that HTR is a useful adjunct in the placement of immediate dental implants for the preservation of ridge width and provides a good base for functional and esthetic prosthetic reconstruction.
Selective Metallization of Silicon Surfaces: The Adsorption of Sterically Stabilized Palladium Particles on H‐Terminated Si(100), , and (1995)

The adsorption of nanometer‐sized, palladium‐phosphorus particles onto , , and H‐terminated Si(100) surfaces is described. These colloidal particles were prepared in aqueous solution by the reduction of Pd2+ with hypophosphite in the presence of polyvinylpyrrolidone (PVP). The sterically stabilized particles catalyze Ni deposition from an electroless solution. High resolution electron microscopy shows that the particle size decreases with increasing PVP concentration in the sol. Several monocrystalline domains were observed in all particle samples. The surface affinity of Pd particles, covered with PVP, and of "free" PVP molecules (i.e., not associated with Pd particles) depends strongly on the type of surface. The large differences in Pd coverage between different types of surface (e.g., and ) offer interesting possibilities for novel pattern‐wise electroless metallization procedures.
Organocatalytic, Regioselective Nucleophilic “Click” Addition of Thiols to Propiolic Acid Esters for Polymer–Polymer Coupling (2013)

Discerning Tastes: The regioselectivity of the nucleophilic addition of thiols to electron-deficient alkynes is controlled by the choice of the solvent (i.e. the polarity of the reaction mixture) and the catalyst. Both thioalkenes and dithianes can be prepared in a rapid reaction that generates no by-products (see scheme). In turn the utility of this reaction is shown for efficient end-group modification of polymers. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Fibroblast growth factor protects the kidney against ischemia-reperfusion injury. (1999)

Ischemia-reperfusion injury, a common source of renal dysfunction in adults, is associated with tubular epithelial cell damage. Since fibroblast growth factors (FGF) attenuated tissue injury after transient myocardial ischemia, we hypothesized that acidic fibroblast growth factor (aFGF; FGF-1) would attenuate renal ischemia-reperfusion injury. We studied the effects of FGF-1 in a rat model of acute renal failure induced by bilateral renal ischemia (60 min) and 1, 2 or 7 days reperfusion. After FGF-1 administration at the onset of renal reperfusion, there was less functional impairment of the kidneys. The histological changes were not as severe as in controls. Increases in serum creatinine and blood urea nitrogen 24 h after reperfusion were attenuated by 35% (p< 0.01) and by 53% (p< 0.001), respectively, in FGF-1-treated animals compared to vehicle-treated rats. The ischemia/reperfusion-induced increase in tissue myeloperoxidase, a marker of neutrophil infiltration, was mitigated (67% reduction, p< 0.05) with FGF-1 treatment. As shown by histology, neutrophil infiltration and tubular cell necrosis in medulla were less pronounced (p< 0.0001 and p< 0.05, respectively) in animals receiving FGF-1. Furthermore, ischemia-induced apoptosis, prevalent in tubular cells of the cortex, was also attenuated by FGF-1-treatment (83% reduction, p< 0.0001). Pretreatment of animals with Nw-nitro-L-arginine (L-NNA), an inhibitor of nitric oxide synthase, abolished the attenuating effects of FGF-1 on neutrophil infiltration, suggesting that nitric oxide might participate in the anti-inflammatory effects of FGF-1 in this experimental design. Our data support a role for FGF-1 in attenuation of renal damage or failure after ischemia-reperfusion injury of the kidney, in part at least by inhibition of neutrophil infiltration.
Mg<sup>2+</sup> Tunes the Wettability of Liquid Precursors of CaCO<sub>3</sub>: Toward Controlling Mineralization Sites in Hybrid Materials (2013)

Amorphous and liquid precursors of calcium carbonate are believed to be central species of biomineralization, which serves as an important inspiration for materials chemists in the quest for new and improved organic-inorganic hybrid materials. It has become increasingly clear that magnesium ions exhibit an important function through kinetic stabilization of the metastable precursors. We show that they additionally tune the wettability of liquid precursors of CaCO3, which is a crucial requirement for successful mineralization of proteinaceous organic matrices. Moreover, tunable wettability offers straightforward means to control mineralization sites in organic-inorganic hybrids.
Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells (2015)

For the past several decades, research in understanding the molecular basis of human aging has progressed significantly with the analysis of premature aging syndromes. Progerin, an altered form of lamin A, has been identified as the cause of premature aging in Hutchinson-Gilford Progeria Syndrome (HGPS), and may be a contributing causative factor in normal aging. However, the question of whether HGPS actually recapitulates the normal aging process at the cellular and organismal level, or simply mimics the aging phenotype is widely debated. In the present study we analyzed publicly available microarray datasets for fibroblasts undergoing cellular aging in culture, as well as fibroblasts derived from young, middle-age, and old-age individuals, and patients with HGPS. Using GeroScope pathway analysis and drug discovery platform we analyzed the activation states of 65 major cellular signaling pathways. Our analysis reveals that signaling pathway activation states in cells derived from chronologically young patients with HGPS strongly resemble cells taken from normal middle-aged and old individuals. This clearly indicates that HGPS may truly represent accelerated aging, rather than being just a simulacrum. Our data also points to potential pathways that could be targeted to develop drugs and drug combinations for both HGPS and normal aging.
Human photosensitivity: from pathophysiology to treatment (2005)

Photosensitivity is a condition detected on the electroencephalography (EEG) as a paroxysmal reaction to Intermittent Photic Stimulation (IPS). This EEG response, elicited by IPS or by other visual stimuli of daily life, is called Photo Paroxysmal Response (PPR). PPRs are well documented in epileptic and non-epileptic subjects. Photosensitivity rarely in normal individuals evolves into epilepsy. Photosensitive epilepsy is a rare refex epilepsy characterized by seizures in photosensitive individuals. The development of modern technology has increased the exposition to potential seizure precipitants in people of all ages, but especially in children and adolescents. Actually, videogames, computers and televisions are the most common triggers in daily life of susceptible persons. The mechanisms of generation of PPR are poorly understood, but genetic factors play an important rule. The control of visually induced seizures has, generally a good prognosis. In patients known to be visually sensitive, avoidance of obvious source and stimulus modifications are very important and useful to seizure prevention, but in the large majority of patients with epilepsy and photosensitivity antiepileptic drugs are needed.
Chromosome <i>8p</i> Deletions and <i>8q</i> Gains are Associated with Tumor Progression and Poor Prognosis in Prostate Cancer (2009)

8p deletions and 8q gains are relatively rare in early stage prostate cancer but often develop during tumor progression. The prognostic effect does not seem to be strong enough to warrant clinical application.