gebhart/patrepeval huggingface dataset:
A139 EQUITY IN ACCESS TO COLORECTAL CANCER SCREENING IN NOVA SCOTIA (2022)

Abstract Background Population-based colorectal cancer (CRC) screening programs aim to minimize inequities in participation through universal access, however, there remain disparities associated with low education, socio-economic status, and population centre. In the United States racialized groups have lower screening participation, and Black and Indigenous adults have higher CRC mortality. There is no Canadian data on racialized group participation in CRC screening because racial and ethnic data is not routinely collected. The Nova Scotia Colon Cancer Prevention Program (NSCCPP) mails fecal immunochemical tests (FIT) biennially to all residents aged 50–74 and allows for optional self-identified race and ethnicity. Aims To determine whether participation rates in the NSCCPP differ on the basis of race/ethnicity, age, sex, or population centre. In this preliminary analysis we report screening participation on the basis of race/ethnicity. Methods A retrospective cohort study was performed using the NSCCPP database to identify screen-eligible adults who returned a FIT to the program (i.e. participated) from 2011 to 2021. Racialized groups were identified based on self-identification form results allowing for multiple category selections. Race/Ethnicity was categorized as White, Black/African Canadian, Indigenous, Asian, Middle Eastern. The 2016 Canadian census was used to estimate the screen-eligible population (age 50–74) and race/ethnicity group population sizes. Unique participants were identified as individuals who returned one or more FITs in the study period. Unique participants were compared to the screen-eligible population to estimate participation over the 10-year study period. Results 508,533 FITs were returned over 10 years by 208,702 unique participants. The number of annual FITs returned ranged from 14,066 in 2011 to 65,746 in 2019. Participants were 56% female, 44% male, with a mean age 62.8 (± 7.0). FIT status was 89% negative, 7% positive, and 4% indeterminate. 96% (n=490,398) of participants provided self-identification data. Table 1 provides the screen-eligible population, unique participants, and FIT participation over the 10-year study period all characterized by race/ethnicity. Over 10 years, 59% of the eligible population participated in CRC screening by returning at least one FIT. Conclusions CRC screening participation by race/ethnicity in Canada is unknown. This analysis of the NSCCPP suggests that participation by racialized individuals including Black/African Canadian, Asian, and Indigenous, are lower relative to White individuals. Further analyses will explore race/ethnicity and gender in terms of temporal and geographic trends. Table 1. Funding Agencies None
Comparative Kinetic Study of Olivine Li[sub x]MPO[sub 4] (M=Fe, Mn) (2004)

A huge kinetic difference in olivine is demonstrated in a quantitative manner. Galvanostatic discharge profiles and the current relaxation to the stepwise anodic overvoltage (chronoamperometry) are comparatively measured for the and under identical extrinsic conditions, which are carefully controlled and confirmed using Rietveld refinement for the X-ray diffraction profiles, direct texture observation by scanning electron microscope, Brunauer-Emmett-Teller surface area measurements, and tap density measurements. The current durability for is orders-of-magnitude inferior to that of the origin of which is clearly attributed to their intrinsic crystallographic and transport property differences. Heavy polaronic holes localized on the sites are suggested as an important rate-limiting factor. In spite of the higher open-circuit voltage of (4.05 V) compared to that of (3.45 V) in the olivine framework, the abnormally large polarization may eliminate pure as a practical lithium battery cathode due to much lower effective energy density than © 2004 The Electrochemical Society. All rights reserved.
Adaptive, asynchronous incremental redundancy (A/sup 2/IR) with fixed transmission time intervals (TTI) for HSDPA (2003)

In anticipation of the high demand for wireless data services, several wireless standards are evolving to support packed data more efficiently. In UMTS, a new, shared channel called the high speed downlink shared channel (HS-DSCH) that multiplexes packet data users has been defined. Several performance-enhancing technologies are included in high speed downlink packet access (HSDPA): adaptive modulation and coding (AMC), hybrid ARQ (HARQ), scheduling etc. HARQ algorithm plays a critical role in HSDPA performance. HARQ techniques are classified in terms of the combining method (chase or incremental redundancy, IR), protocol timing (synchronous or asynchronous) and adaptivity (if modulation/code-rate can be changed for retransmission or not). In previous work (Das et al. 2001), an adaptive, asynchronous, incremental redundancy (A/sup 2/IR) scheme was proposed and shown to provide substantial gains over other HARQ options. In this paper, the design and performance aspects of A/sup 2/IR in the code domain (as against the time domain in Das et al.) are considered. Due to the higher bandwidth of the UMTS channels compared to cdma2000 or HDR, it is expected that code-division multiplexing (CDM) of users will be needed to "fill the data pipe" instead of pure time-division multiplexing. The paper also analyzes tradeoffs that are unique to implementing A/sup 2/IR with CDM. A/sup 2/IR with a fixed TTI is now part of UMTS Release 5.
Oligomerization within Virions and Subcellular Localization of Human Immunodeficiency Virus Type 1 Integrase (1999)

Previous biochemical and genetic evidence indicated that the functional form of retroviral integrase protein (IN) is a multimer. A direct demonstration of IN oligomerization during the infectious cycle was, however, missing, due to the absence of a sensitive detection method. We describe here the generation of infectious human immunodeficiency virus type 1 (HIV-1) viral clones carrying IN protein tagged with highly antigenic epitopes. In this setting, we could readily visualize IN both in producer cells and in viral particles. More interestingly, we detected IN oligomers, the formation of which was dependent on disulfide bridges and took place inside virions. Additionally, expression of a tagged HIV-1 IN in the absence of other viral components resulted in almost exclusive nuclear accumulation of the protein. Mutation of a conserved cysteine in the proposed dimer interface determined the loss of viral infectivity, associated with a reduction of IN oligomer formation and the redistribution of the mutated protein in the nucleus and cytoplasm. Epitope tagging of HIV-1 IN expressed alone or in the context of a replication-competent viral clone provides powerful tools to validate debated issues on the implication of this enzyme in different steps of the viral cycle.
Pharyngeal Pressure Analysis by the Finite Element Method during Liquid Bolus Swallow (2000)

The human pharynx is unique, acting as a complex interchange between the oral cavity and the esophagus, and between the nasal cavity and the lungs. It is actively involved in the transport of food and liquid, producing the forces that guide the bolus into the upper esophagus and away from the adjacent larynx and lungs. This study developed a biomechanical computer model of the human pharynx, utilizing a finite element method (FEM). Control 2-dimensional cine computed tomography images were obtained during 10-mL barium paste swallows at 8 levels extending from the tongue base to the cricopharyngeal level in order to encompass the entire pharynx. Three-dimensional finite element models of the pharynx were reconstructed from the geometric information obtained from the images at each level. Using an inverse dynamic approach with the addition of known tissue properties, we analyzed the 8 models under estimated pressure histories during swallow. Within each model, changes in the cross-sectional intraluminal area were calculated and compared with the area from the computer-generated FEM model. Area matching allowed estimation of intraluminal pressure gradients during swallow. The estimated pressure gradients were distributed through a range from 10 to 55 mm Hg, varying from one region to another and showing different patterns for the upper 4 levels and the lower 4 levels. The contraction velocity for the upper 4 levels was much higher than that for the lower 4 levels. The higher contraction velocities and pressure gradients in the upper levels are consistent with the bolus velocities required for efficient swallow.
Banal Catalanism? (2000)

Michael Billig's book Banal Nationalism (1995) set out to expose the covert ways in which established nation-states reinforce their legitimacy by constantly 'flagging' the national identity to their citizens. He terms this kind of nationalism 'banal', in contrast with more obvious 'hot' nationalist movements. This article applies Billig's theory of 'banal nationalism' not to an established nation-state but to present-day Catalonia, an 'historic nation' which now enjoys a large measure of autonomy. The article argues that in Catalonia, forms of 'banal nationalism' are generated by Catalan institutions, exist in competition with the 'banal nationalism' of the Spanish State, and might be partly responsible for the 'cooling' of Catalanism which is currently worrying some Catalanists.
Voice transmission at a very low bit rate on a noisy channel: 800 bps vocoder with error protection to 1200 bps (1992)

A codec was studied at 800 b/s source coding and total bit rate of 1200 b/s after error protection. After an LPC 10 analysis, the 800-b/s coder encodes several frames together in order to use the intercorrelation between successive frames. The coder chooses from eight different spectrum coding schemes the one which best corresponds to the speech on the superframe, viz. the energy is quantized by a VQ of the evolution of the power on the superframe and a scalar quantization of a reference energy. The redundancy of 3/2 (1200/800) is filled up with block codes. Comparison between, on the one hand, BCH(63,36) codes and, on the other hand, a combination of Golay codes and short BCH gives, after mathematical simulations and listening tests, an advantage to the latter protection scheme. The vocoder remains nearly unaltered up to 3% BER on the 1200 b/s channel and is intelligible up to 5% BER.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials. (2001)

Centrally acting cholinesterase inhibitors (ChEls) improve cognitive functions in Alzheimer's disease (AD) and other forms of dementia. Evaluation of treatment efficacy is based mainly on subjective assessment tools which includes standardized neuropsychological tests. Therefore, an additional objective tool for the evaluation of drug response is necessary. Thirty two patients were treated with ChEls for dementia (tacrine 19, donepezil 5, rivastigmine 8). Cognitive response was assessed before ChEls (baseline) and after 26 weeks, as optimal tolerated doses were achieved and maintained (endpoint). Evaluation included repeated measurements of Mini Mental State Examination (MMSE), ADAS-cog and P300. For statistical analysis we used ANOVA with repeated measures and Pearson correlation coefficient. Results demonstrated improvement of mean ADAS-cog by 2.0 points (from 29.4 to 27.4 p = 0.08) while MMSE remained almost unchanged (20.1 to 19.8). Mean P300 latency reduced significantly by 24 msec (from 383 msec to 359 msec, p = 0.0001) thus reflecting the clinical improvement. However mean amplitudes did not change from baseline to endpoint (13 microvolts). Significant correlation was found between mean ADAS-cog and mean P300 latency at baseline and end-point (R = 0.452 p = 0.014, R = 0.567 p = 0.001 respectively). Strong correlation was found between mean MMSE and P300 latency at Baseline (R = -0.335 p = 0.07), and significant correlation was found at endpoint (R = -0.613 p < 0.001). Our data suggests that P300 is a reliable instrument for assessment of cognitive response to ChEls in demented patients.
Seasonal changes in the ratio of serum urea to creatinine in feeding and fasting polar bears (1991)

When mammals fast, the ratio of serum urea to serum creatinine (U/C) typically rises. Blood samples from 668 free-ranging polar bears (Ursus maritimus) of differing nutritional status were collected for determination of serum concentrations of urea and creatinine. Adult female polar bears in spring that had just emerged with their cubs from dens and had been without food for more than 7 months had markedly low U/C values. This atypical pattern of U/C levels during a fast is similar to that of black bears (Ursus americanus) at the end of their overwinter fast. Whereas black bears only show reduced U/C values during their overwinter fast, however, some polar bears had low serum U/C values in all seasons, suggesting that those bears were in a nutritional state similar to that of a fasting and winter dormant bear. We suggest that when food is unavailable, regardless of the time of year, polar bears can rapidly adopt appropriate physiological and biochemical means to control urea recycling and, consequently, are one of the most proficient terrestrial mammals at undertaking extended fasts.
Antimicrobial Effectiveness of Povidone-Iodine and Consequences for New Application Areas (2002)

The microbicidal action spectrum of povidone-iodine (PVP-I) is broad - even after short onset times. Unlike local antibiotics and other antiseptic substances, no resistance develops. The high degree of bactericidal efficiency in respect of highly resistant gram-positive pathogenic micro-organisms, such as methicillin-resistant Staphylococcus aureus (MRSA) and enterococcus strains, is particularly significant for hospital hygiene. An in vitro study with 10 genotypically different MRSA isolates showed an optimum bactericidal effect (logarithmic reduction factor value >5) without protein load after just 30 s exposure and even in a dilution of Betaisodona solution (Mundipharma GmbH) of 1%. With protein load (0.2% albumin), the optimum in microbicidal effectiveness shifts to concentrations > or = 10% Betaisodona solution referring to an exposure time of 30 s. Since recent results are now also available on the toxicological safety of PVP-I preparations for the ciliated epithelium of the nasal mucosa and the good tolerability on skin and other mucous membranes is a known factor, a controlled clinical study is currently being carried out to eliminate colonizations of MRSA. Evidence has also recently been produced of the antiviral activity of PVP-I against herpes simplex, adeno- and enteroviruses, as well as its high degree of efficiency against Chlamydia. Hence alongside the classical fields of application, such as the disinfection of the skin and hands, mucosa antisepsis and wound treatment, there are also useful indications for the substance, i.e. rinsing of body cavities and joints and application to the eye.
[Microsatellite instability in renal cell carcinoma and its mechanisms]. (2001)

MSI and expression of MMR genes are associated events in RCC. The effect of gene mutation on tumorgenerasis may be related to MSI.
Purification and characterization of peptidylglycine alpha-amidating monooxygenase from bovine neurointermediate pituitary. (1986)

Extracts of bovine neurointermediate pituitary secretory granules and frozen bovine neurointermediate pituitary contain multiple forms of peptidylglycine alpha-amidating monooxygenase (PAM) activity differing in apparent molecular weight and in charge. Metal chelate affinity chromatography, substrate affinity chromatography, and gel filtration resulted in the purification of two forms of amidation activity from frozen bovine neurointermediate pituitary: PAM-A, apparent molecular weight 54,000, was purified 7,000-fold and PAM-B, apparent molecular weight 38,000, was purified 21,000-fold. Enzyme activity of similar molecular weights was observed in the starting material. Purified PAM-A and PAM-B correspond to two of the three charge forms present in crude extracts, and both exhibited optimal activity at alkaline pH. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of PAM-B revealed the presence of two bands with apparent molecular weights of 42,000 and 37,000; autoradiography of 125I-labeled PAM-B revealed only the same two bands, and 125I-labeled PAM-B co-eluted with enzyme activity during gel filtration. PAM-A was still heterogeneous based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The properties of purified PAM-A and PAM-B were very similar to those of amidation activity in crude extracts: activity was reduced upon removal of molecular oxygen; activity was stimulated by the addition of CuSO4 and eliminated by the addition of diethyldithiocarbamate; activity was stimulated by the addition of ascorbate, with optimal levels of ascorbate increasing as the concentration of peptide substrate was increased. In the presence of 1.25 mM ascorbate, PAM-B exhibited a Km of 7.0 microM for D-Tyr-Val-Gly and a Vmax of 84 nmol/micrograms/h.
The new cholesterol guidelines (2002)

In 2001, the National Institutes of Health released the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Compared with previous cholesterol guidelines, the new guidelines contain several significant changes in treatment recommendations for patients with hyperlipidemia. In this article, Dr Pearlman reviews the latest guidelines and offers case examples that demonstrate how to incorporate the recommendations routinely into clinical practice.
Real time power estimation and thread scheduling via performance counters (2009)

Estimating power consumption is critical for hardware and software developers, and of the latter, particularly for OS programmers writing process schedulers. However, obtaining processor and system power consumption information can be non-trivial. Simulators are time consuming and prone to error. Power meters report whole-system consumption, but cannot give per-processor or per-thread information. More intrusive hardware instrumentation is possible, but such solutions are usually employed while designing the system, and are not meant for customer use. Given these difficulties, plus the current availability of some form of performance counters on virtually all platforms (even though such counters were initially designed for system bring-up, and not intended for general programmer consumption), we analytically derive functions for real-time estimation of processor and system power consumption using performance counter data on real hardware. Our model uses data gathered from microbenchmarks that capture potential application behavior. The model is independent of our test benchmarks, and thus we expect it to be well suited for future applications. We target chip multiprocessors, analyzing effects of shared resources and temperature on power estimation, leveraging our model to implement a simple, power-aware thread scheduler. The NAS and SPEC-OMP benchmarks shows a median error of 5.8% and 3.9%, respectively. SPEC 2006 shows a marginally higher median error of 7.2%.
AlGaAs-InGaAs slab-coupled optical waveguide lasers (2003)

The slab-coupled optical waveguide laser (SCOWL) concept, recently proposed and demonstrated, is extended to the AlGaAs-InGaAs-GaAs material system. Both 980- and 915-nm SCOWL devices feature a nearly circular large-diameter single-spatial mode that can be butt coupled with high efficiency to a single-mode fiber. Single-ended continuous-wave output powers of greater than 1 W have been obtained at 980 nm.
Comment on Gas/Particle Partitioning of Two Acid−Base Active Compounds in Mainstream Tobacco Smoke: Nicotine and Ammonia (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCorrespondence/Rebut...Correspondence/RebuttalNEXTComment on Gas/Particle Partitioning of Two Acid−Base Active Compounds in Mainstream Tobacco Smoke: Nicotine and AmmoniaJohn H. Lauterbach*View Author Information Lauterbach & Associates, LLC, 211 Old Club Court, Macon, Georgia 31210-4708*Phone (478) 474-8818; fax (478) 474-0117; e-mail [email protected]Cite this: J. Agric. Food Chem. 2010, 58, 16, 9287–9288Publication Date (Web):August 2, 2010Publication History Received29 July 2009Published online2 August 2010Published inissue 25 August 2010https://doi.org/10.1021/jf902220rCopyright © 2010 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views370Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (621 KB) Get e-AlertsSUBJECTS:Ammonia,Atmospheric chemistry,Cellulose,Nicotine,Particulate matter Get e-Alerts
Burden of Disease Caused by Otitis Media: Systematic Review and Global Estimates (2012)

Our study is the first attempt to systematically review the available information and provide global estimates for OM and related conditions. The overall burden deriving from AOM, CSOM and their sequelae is considerable, particularly in the first five years of life and in the poorest countries. The findings call for incorporating OM-focused action within preventive and case management strategies, with emphasis on the more affected.
Successful treatment of painful traumatic mononeuropathy with carbamazepine: insights into a possible molecular pain mechanism (1997)

The delayed onset of painful paresthesias following trauma to a peripheral nerve is a well recognized but poorly understood phenomenon. This report describes an illustrative case of painful paresthesias in the territory of the ilioinguinal nerve, 3 to 6 weeks after an otherwise routine herniorraphy, which subsequently responded dramatically to carbamazepine. The case is considered in light of recent studies which have determined molecular changes which occur in dorsal root ganglion (DRG) neurons following axotomy and neuroma formation. Voltage-dependent sodium (Na+) channels in DRG neurons undergo a change following axotomy, in which there is significant up- and down-regulation of different subpopulations of Na channels over a time frame measured in days to weeks. Such changes may render the DRG neurons hyperexcitable, thus contributing to a neuropathic pain syndrome, yet susceptible to treatment with a sodium channel blocker such as carbamazepine.