gebhart/patrepeval huggingface dataset:
Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney (1997)

In this report we investigate the molecular mechanisms that contribute to tissue damage following ischemia and ischemia coupled with reperfusion (ischemia/reperfusion) in the rat heart and kidney. We observe the activation of three stress-inducible mitogen-activated protein (MAP) kinases in these tissues: p38 MAP kinase and the 46- and 55-kDa isoforms of Jun N-terminal kinase (JNK46 and JNK55). The heart and kidney show distinct time courses in the activation of p38 MAP kinase during ischemia but no activation of either JNK46 or JNK55. These two tissues also respond differently to ischemia/reperfusion. In the heart we observe activation of JNK55 and p38 MAP kinase, whereas in the kidney all three kinases are active. We also examined the expression pattern of two stress-responsive genes, c-Jun and ATF3. Our results indicate that in the heart both genes are induced by ischemia and ischemia/reperfusion. However, in the kidney c-Jun and ATF3 expression is induced only by ischemia/reperfusion. To correlate these molecular events with tissue damage we examined DNA laddering, a common marker of apoptosis. A significant increase in DNA laddering was evident in both heart and kidney following ischemia/reperfusion and correlated with the pattern of kinase activation, supporting a link between stress kinase activation and apoptotic cell death in these tissues.
미켈 뒤프렌 미학의 정감적 a priori 개념 (2000)

미켈 뒤프렌(이하 뒤프렌)의 미학적 문제는 「Phe＇nom e＇nologe de L`exp e＇rience Esth e＇tique」에서 논하듯 현상학적Phenomenological 규명이다. 그는 모든 진정한 직관은 표현이고 예술은 직관에 의한 표현할동이며 예술은 정신의 형식의 구조상 최초의 것이고 가장 직접적인 지식의 형태로 믿고 있다. 이화 같은 분석은 수행하기 위하여 뒤프렌이 사용한 방법은 훗날 현상학 Phenomenology이라고 불리는 후설Husserl의 지향성이라는 현상학적 방법에 접근한다.
뒤프렌은 미적 경험의 현상학적 분석에 있어 미적 경험을 정초하고 가능하게 하는 개념으로 아 프리오리apriori를 설정하고 있다. 선험적 분석을 통하여 미적 경험을 분석함과 아울러 인간과 예술작품 사이의 상관관계를 존재론적인 의미 파악을 하고자 하였다. 그 개념은 정감적(affectif) a priori 개념이다.
a priori 개념을 바탕으로 한 미적 경험을 현상학적으로 분석한 미학체계는 실질적으로 선험적이며 현상학적 관점의 총체를 보이고 있는 것으로 그러한 복합적 관점을 뒤프렌은 아 프리오리를 통하여 해결하고자 하였다. 이 과정에서 그는 한편 미적 대상을 구성하는 아 프리오리로서 정감적 특질과 한편으로는 정감적 특질을 인지하도록 허락하는 정감적 범주가 아 프리오리한 지식으로 주관에 있다는 점을 통해서 미적 경험이 가능해진다고 주장한다.
그러므로 미적 경험은 정감적인 향수자의 감정이 대상에서의 정감적 구조이 미적 대상의 표현적 의미를 읽어낼 때 절정을 이루고 있다. 이러한 표현적 의미가 아 프리오리로서의 정감적 특질에 의한 통일되는 미적 대상의 의미이다.그리고 주관은 감정이 표현적 의미에 의해서 일?틸痴仄藪?앞서 의미에 대한 아 프리오리한 지식을 가지고 있는데 이러한 잠재적인 지식은 감정이 표현적 의미를 읽어낼 때 현실화된다.
뒤프렌의 미학에 있어서 감정을 충만하게 해주는 미적 경험은 의식의 실존적인 것 즉 인간에 의해 체험된 지각적이고 정감적인 감정에 근거를 두고 있다고 보며 이러한 미적 행위는 감각적인 영역에 관여되고 있고 미적 경험을 통한 감각적 현현의 개념이 중심개념이다. 따라서 정감의 아 프리오리로서의 감정이란 그 현현으로서의 감정인 것이다. 이것이 곧 지향성의 관념에 따른 정감적 아 프리오리로서의 감정의 세계이며 뒤프렌의 미적 경험의 세계이다
Structures for additive pulse mode locking (1991)

The theory of additive pulse mode locking (APM) is developed in closed form under a linearization approximation. The pulse parameters are determined in terms of the gain, the gain dispersion, the group-velocity dispersion, and the self-phase modulation. Stability regimes are established. Various possible configurations of laser systems that can produce APM are presented. Some of them permit single-cavity realizations that may not require interferometric length stabilization circuits. In general, the results are applicable to a wide range of fast saturable absorber mode-locked systems.
Amiloride Analogs as<scp>ASIC</scp>1a Inhibitors (2016)

Addition of a benzyl group to the terminal guanidinyl group resulted in enhanced inhibitory activity on ASIC1a. On the other hand, the bulky groups added to the 5-amino residues slightly decreased the activity. Among the tested amiloride analogs, benzamil is the most potent ASIC1a inhibitor.
A clustering algorithm applied to the network management on mobile ad hoc network (2002)

With the development of a mobile ad hoc network (MANET), it needs network management to guarantee the network reliability and efficiency. However, the properties of a MANET are unique compared with other communication networks, hence, a new clustering algorithm with token mechanism and minimum ID putting the special existing unidirectional links and relative mobility etc. into consideration is proposed in this paper. It is applied to the network management of the mobile ad hoc network for clustering based on a hierarchical management framework including the manager, cluster heads and agents. We suggest a new method for mobile ad hoc network management. The amelioration to MIB is suggested as well.
Avalanche Capability of Vertical GaN p-n Junctions on Bulk GaN Substrates (2015)

Inductive avalanche test results presented in this letter demonstrate that GaN p-n diodes can sustain single-pulse and repetitive inductive avalanche currents. The 0.36-mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> vertical GaN p-n diodes can sustain single-pulse avalanche currents as high as 10 A. The safe zone of the single-pulse avalanche current is limited by peak pulse power and energy deposited in the device. The temperature-dependent behavior of the breakdown voltage and the reverse-voltage at onset of avalanche has a positive temperature coefficient. Repetitive avalanche ruggedness testing was performed by applying 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> pulses at 5-kHz frequency with increasing repetitive stress current. Based on a population of 63 devices, the incremental failure rate under repetitive avalanche current increases with increasing avalanche current. The devices that survive the step stress test sustain no parametric drift under repetitive avalanche.
Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC) (2007)

7554 Background: After complete resection, about 50% of patients with stages IB-II NSCLC disease die within 5 years. Adjuvant chemotherapy improves overall survival at the expense of substantial toxicity. Activity of MAGE-A3 immunotherapeutic (i.e. recombinant MAGE-A3 protein and a potent GlaxoSmithKline adjuvant) was previously demonstrated in metastatic melanoma. As about 35% of NSCLCs express MAGE-A3 antigen, post-operative MAGE-treatment may be a tumor-specific, well tolerated, and effective adjuvant therapy. Methods: Patients with completely resected, MAGE-A3 (+), stage pIB or pII were randomly assigned to postoperative MAGE-A3 or placebo (2:1), with 5 administration at 3-week intervals, followed by 8 administrations every 3 months. Randomization was stratified for stage (IB vs. II), histology (squamous vs. other), and lymph-node (LN) procedure (sampling vs. dissection). Primary endpoint was disease-free interval (DFI); other endpoints were safety, disease-free survival (DFS), and overall survival (OS). This exploratory Phase II study was designed to detect a clinically relevant HR with a 10% one-sided a. Results: 182 patients (122 stage IB, 60 stage II) from 59 centers in 14 countries were randomized over 2 years: Median age 63 (45–81); 87% male; 65% squamous cell carcinoma; 65% lymph-node dissection. After a median follow-up of 28 months, 67 recurrences and 45 deaths were recorded. Group comparisons of DFI, DFS and OS gave respectively a hazard ratio (HR) of 0.74 (95% CI 0.44–1.20, p=0.107), 0.73 (95% CI 0.45–1.16) and 0.66 (95% CI 0.36–1.20) in favor of the MAGE-A3 group. Overall, treatment was well tolerated, with excellent protocol compliance. Subset analysis also suggests that LN dissection may have an effect on survival. Conclusions: The final analysis of this randomized phase II study shows a positive trend for activity of MAGE-A3 treatement in NSCLC with a relative improvement of DFI and DFS of 27%. Further phase III evaluation is planned. This study also suggests that complete lymph-node dissection may have an effect on survival and should be confirmed prospectively. [Table: see text]
LifeLines: visualizing personal histories (1996)

LifeLines provide a general visualization environment for personal histories that can be applied to medical and court records, professional histories and other types of biographical data. A one screen overview shows multiple facets of the records. Aspects, for example medical conditions or legal cases, are displayed as individual time lines, while icons indicate discrete events, such as physician consultations or legal reviews. Line color and thickness illustrate relationships or significance, rescaling tools and filters allow users to focus on part of the information. LifeLines reduce the chances of missing information, facilitate spotting anomalies and trends, streamline access to details, while remaining tailorable and easily transferable between applications. The paper describes the use of LifeLines for youth records of the Maryland Department of Juvenile Justice and also for medical records. User's feedback was collected using a Visual Basic prototype for the youth record.
Purification and Some Properties of Agarase from Pseudomonas sp. PT-5. (1991)

An agarase (agarose 4-glycanohydrolase, EC 3.2.1.81) was purified from the culture fluid of Pseudomonas sp. PT-5 by ammonium sulfate precipitation followed by Cellulofine GC-700m, Hydroxyapatite, Butyl-Toyopearl 650M, and Toyopearl-HW 508 column chromatography. The purified enzyme gave a single band on polyacrylamide gel disc electrophoresis and its molecular weight was 31, 000 by SDS-polyacrylamide gel electrophoresis. The isoelectric point of the enzyme was 3.6. The amino-terminal sequence was H•Ala-Asp-Trp-Asp-Gly-Leu-Ala-Val-Pro-Ala-Asp-Ala-Gly-Asp-Gly-. The enzyme was stable from pH 6 to 9 and had its maximum activity at pH 8.5. The enzyme rapidly reduced the viscosity of agarose solution and its activity was greatly inhibited by metal ions such as Zn2+, Cu2+, Co2+, Fe2+, and Al3+ at 1 mM concentration. The enzyme activity was elevated by 75% in the presence of 0.1 M NaCl.
Crystal Structure of the δ′ Subunit of the Clamp-Loader Complex of E. coli DNA Polymerase III (1997)

The crystal structure of the δ′ subunit of the clamp-loader complex of E. coli DNA polymerase III has been determined. Three consecutive domains in the structure are arranged in a C-shaped architecture. The N-terminal domain contains a nonfunctional nucleotide binding site. The catalytic component of the clamp-loader complex is the γ subunit, which is homologous to δ′. A sequence-structure alignment suggests that nucleotides bind to γ at an interdomain interface within the inner surface of the “C.” The alignment is extended to other clamp-loader complexes and to the RuvB family of DNA helicases, and suggests that each of these is assembled from C-shaped components that can open and close the jaws of the “C” in response to ATP binding and hydrolysis.
Infectious diseases associated with complement deficiencies (1991)

The complement system consists of both plasma and membrane proteins. The former influence the inflammatory response, immune modulation, and host defense. The latter are complement receptors, which mediate the cellular effects of complement activation, and regulatory proteins, which protect host cells from complement-mediated injury. Complement activation occurs via either the classical or the alternative pathway, which converge at the level of C3 and share a sequence of terminal components. Four aspects of the complement cascade are critical to its function and regulation: (i) activation of the classical pathway, (ii) activation of the alternative pathway, (iii) C3 convertase formation and C3 deposition, and (iv) membrane attack complex assembly and insertion. In general, mechanisms evolved by pathogenic microbes to resist the effects of complement are targeted to these four steps. Because individual complement proteins subserve unique functional activities and are activated in a sequential manner, complement deficiency states are associated with predictable defects in complement-dependent functions. These deficiency states can be grouped by which of the above four mechanisms they disrupt. They are distinguished by unique epidemiologic, clinical, and microbiologic features and are most prevalent in patients with certain rheumatologic and infectious diseases. Ethnic background and the incidence of infection are important cofactors determining this prevalence. Although complement undoubtedly plays a role in host defense against many microbial pathogens, it appears most important in protection against encapsulated bacteria, especially Neisseria meningitidis but also Streptococcus pneumoniae, Haemophilus influenzae, and, to a lesser extent, Neisseria gonorrhoeae. The availability of effective polysaccharide vaccines and antibiotics provides an immunologic and chemotherapeutic rationale for preventing and treating infection in patients with these deficiencies.
Pivot Table Data Crunching for Microsoft(R) Office Excel(R) 2007 (Business Solutions) (2006)

This book consolidates all the best functionality of pivot tables into one guide that provides you with a meaningful tutorial, offering practical solutions to day-to-day problems.Within just the first 2 chapters, you will be creating basic pivot tables, increasing productivity, and producing reports in minutes instead of hours.Within the first 6 chapters, you will learn how to use pivot tables to quickly highlight your top 10 customers or bottom 5 products in profitability; quickly create analysis comparing sales this period to last period by product or region or both; easily summarize daily transactional data by month or quarter or year in a few mouse clicksi¾all without knowing any formulas!By the end of the book, you will truly be a pivot table guru, automating pivot tables using VBA, creating pivot tables with external data in OLAP cubes, and even creating dynamic reporting systems so that your managers can answer their own queries with a few mouse clicks.· Take advantage of the numerous pivot table recipes· Create powerful summary reports in seconds· Build ad-hoc query tools with ease· Enhance your Executive Reporting· Filter reports to top 10 customers or products· Add dynamic charts to reports· Quickly summarize daily data by month, quarter, or yearIntroduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Pivot Table Fundamentals . . . . . . . . . . . . . . . . . . . . . . . . . . . .11 2i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Creating a Basic Pivot Table . . . . . . . . . . . . . . . . . . . . . . . . . .21 3i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Customizing a Pivot Table . . . . . . . . . . . . . . . . . . . . . . . . . . . .45 4i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Controlling the Way You View Your Pivot Data . . . . . . . . . . . .83 5i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Performing Calculations Within Your Pivot Tables . . . . . . . . 117 6i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Using Pivot Charts and Other Visualizations . . . . . . . . . . . . .141 7i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Analyzing Disparate Data Sources with Pivot Tables . . . . . . 167 8i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Sharing Pivot Tables with Others . . . . . . . . . . . . . . . . . . . . . .189 9i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Working with and Analyzing OLAP Data . . . . . . . . . . . . . . . . 201 10i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Enhancing Your Pivot Table Reports with Macros . . . . . . . . .215 11i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Using VBA to Create Pivot Tables . . . . . . . . . . . . . . . . . . . . . 231 12i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Common Pivot Table Issues and Questions . . . . . . . . . . . . . .291 Ai¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ i¾ Finding Pivot Table Commands on the Ribbon . . . . . . . . . . . .315
Multiconductor Transmission Lines In Multilayered Dielectric Media (1984)

A method for computing the capacitance matrix and inductance matrix for a multiconductor transmission line in a multilayered dielectric region is presented. The number of conductors and the number of dielectric layers are arbitrary. Some of the conductors may be of finite cross section and others may be infinitesimally thin. The conductors are either above a single ground plane or between two parallel ground planes. The formulation is obtained by rising a free-space Green's function in conjunction with total charge on the conductor-to-dielectric interfaces and polarization charge on the dielectric-to-dielectric interfaces. The solution is effected by the method of moments using pulses for expansion and point matching for testing. Computed results are given for some cases where all conducting lines are of finite cross section and other cases where they are infinitesimally thin.
Modifying PDF Files (2016)

Many people share PDF files but many times you may need to modify the contents of those PDF files. That could mean filling out forms or adding a signature. Fortunately, you can modify PDF files on a Macintosh so you never need to buy special PDF editing software.
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system (1994)

An in vivo system in which expression of a synthetic influenza virus-like chloramphenicol acetyltransferase (CAT) RNA is driven by influenza virus proteins synthesized from cloned cDNAs has been developed. Expression of the four influenza virus core proteins (nucleoprotein, PA, PB1 and PB2) was performed by transfection of four pGEM recombinant plasmids, each containing one of the four viral genes, into cell cultures previously infected with a vaccinia virus recombinant encoding the T7 RNA polymerase (vTF7-3). When a naked negative-sense influenza virus-like CAT RNA was transfected into cells expressing the four influenza virus proteins, CAT activity was detected in the cell extracts, demonstrating that the expressed proteins had RNA-synthesizing activity. In this system, CAT RNA templates containing additional nucleotides at the 3' end were also expressed, resulting in CAT activity. This showed that the influenza virus polymerase can recognize its promoter when located internally on an RNA template. In influenza virus-infected cells however, CAT activity was detected only when the CAT RNA contained the viral promoter at the exact 3' end and was transfected as in vitro assembled ribonucleoprotein. These results are discussed in terms of the different requirements of the two helper systems for expression of an exogenously added RNA.
Tissue Tracking and Registration for Image-Guided Surgery (2012)

Vision-based tracking of tissue is a key component to enable augmented reality during a surgical operation. Conven- tional tracking techniques in computer vision rely on identifying strong edge features or distinctive textures in a well-lit environ- ment; however endoscopic tissue images do not have strong edge features, are poorly lit and exhibit a high degree of specular reflection. Therefore, prior work in achieving densely populated 3D features for describing tissue surface profiles require complex image processing techniques and have been limited in providing stable, long-term tracking or real-time processing. In this paper, we present an integrated framework for ac- curately tracking tissue in surgical stereo-cameras at real-time speeds. We use a combination of the STAR feature detector and Binary Robust Independent Elementary Features to acquire salient features that can be persistently tracked at high frame rates. The features are then used to acquire a densely-populated map of the deformations of tissue surface in 3D. We evaluate the method against popular feature algorithms in in-vivo animal study video sequences, and we also apply the proposed method to human partial nephrectomy video sequences. We extend the salient feature framework to support region tracking in order to maintain the spatial correspondence of a tracked region of tissue or a medical image registration to the surrounding tissue. In-vitro tissue studies show registration accuracies of 1.3-3.3 mm using a rigid-body transformation method.
Therapeutic efficacy of <sup>177</sup>Lu‐CHX‐A″‐DTPA‐hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy (2008)

177Lu-hu3S193 RIT is effective as a single agent in the treatment of Le(y) positive prostate cancer models. The enhancement of RIT by AG1478 or docetaxel indicates the promise of combined modality strategies.
Scalable and Low-Latency Data Processing with Stream MapReduce (2011)

We present StreamMapReduce, a data processing approach that combines ideas from the popular MapReduce paradigm and recent developments in Event Stream Processing. We adopted the simple and scalable programming model of MapReduce and added continuous, low-latency data processing capabilities previously found only in Event Stream Processing systems. This combination leads to a system that is efficient and scalable, but at the same time, simple from the user's point of view. For latency-critical applications, our system allows a hundred-fold improvement in response time. Notwithstanding, when throughput is considered, our system offers a ten-fold per node throughput increase in comparison to Hadoop. As a result, we show that our approach addresses classes of applications that are not supported by any other existing system and that the MapReduce paradigm is indeed suitable for scalable processing of real-time data streams.
Adalimumab effectively reduces the rate of anterior uveitis flares in patients with active ankylosing spondylitis: results of a prospective open-label study (2008)

Results of this prospective open-label study suggest that adalimumab had a substantial preventive effect on AU flares in patients with active AS, including patients with a recent history of AU flares. Clinical trials: ClinicalTrials.gov Identifier: NCT00478660.
Faster plan generation through consideration of functional dependencies and keys (2016)

It has been a recognized fact for many years that query execution can benefit from pushing group-by operators down in the operator tree and applying them before a join. This so-called eager aggregation reduces the size(s) of the join argument(s), making join evaluation faster. Lately, the idea enjoyed a revival when it was applied to outer joins for the first time and incorporated in a state-of-the-art plan generator. However, this recent approach is highly dependent on the use of heuristics because of the exponential growth of the search space that goes along with eager aggregation. Finding an optimal solution for larger queries calls for effective optimality preserving pruning mechanisms to reduce the search space size as far as possible. By a more thorough investigation of functional dependencies and keys, we provide a set of new pruning criteria and evaluate their effectiveness with respect to the runtime and memory consumption of the resulting plan generator.
A positive feedback loop couples Ras activation and CD44 alternative splicing (2006)

The Ras signaling pathway is important in both cell proliferation and tumor progression. Alternatively spliced isoforms of CD44 containing variable exon 6 (v6) can serve as coreceptors for growth factor receptors that activate Ras. Here we use v6-specific small interfering RNA (siRNA) to investigate the role of CD44 alternative splicing in Ras signaling. We identify a positive feedback loop in which Ras signaling promotes CD44v6 splicing, and CD44v6 then sustains late Ras signaling, which is important for cell cycle progression. These results are the first demonstration of a positive feedback loop linking signaling-dependent alternative splicing to mitogenic progression.