gebhart/patrepeval huggingface dataset:
11th Annual Inflammatory and Immune Diseases Drug Discovery and Development Summit (2007)

The Strategic Research Institute (SRi) hosted the 11th International Inflammation and Immune Diseases Drug Discovery and Development World Summit in San Francisco during 12-13 March 2007. The summit comprised keynote sessions and two parallel tracks and focussed on targeting mechanisms for drug discovery and development, which modulate the immune response and which have anti-inflammatory activity in a number of human diseases. Indications included psoriasis, hepatitis C, allergic dermatitis, systemic lupus erythematosus, rheumatoid arthritis and osteoarthritis, multiple sclnerosis, cardiovascular disease and asthma. Data were presented supporting all stages of drug discovery from target identification and validation through to lead identification and optimisation to both early- and late-stage clinical development.
The clinical potentials of endogenous neurosteroids (2002)

Stress increases plasma and brain concentrations of the neurosteroids allopregnanolone and allotetrahydrodeoxycorticosterone (THDOC), which can have potent effects on GABAA receptors in the brain. Blockade of the formation of neurosteroids prevents specific biochemical and behavioral effects of stress, suggesting that those effects are dependent upon the actions of GABA(A)-receptor active neurosteroids. Recent investigations provide a better understanding of the role of endogenous neurosteroids in normal neuronal development and in the pathophysiology of brain disorders. Physiological neurosteroid fluctuations have potential implications for stress-sensitive neurological conditions such as epilepsy, infantile spasms, as well as psychiatric disorders such as schizophrenia, posttraumatic stress disorder and depression. Future studies may provide important new evidence that may not only explain acute actions of stress, but also reveal the clinical importance of neurosteroid mechanisms during chronic stress.
Gain tilt of erbium-doped fiber amplifiers due to signal-induced inversion locking (1993)

A theoretical analysis describing an interpretation of the fundamental processes, responsible for the second-order distortion of AM signals in erbium-doped fiber amplifiers (EDFAs) is presented. It is shown that the locked-inversion gain tilt rather than the widely used continuous wave gain tilt is responsible for the distortion. The theoretical analysis is confirmed by experiments showing that the two types of gain tilt may differ by factors of up to 60. In particular, it is demonstrated that the locked-inversion gain-tilt may be significant even at the CW gain peak. Experimental results indicate that the relevant gain tilt can be reduced to acceptable levels by proper design of the EDFA.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Clinicopathological Significance of Leucine-Rich α2-Glycoprotein-1 in Sera of Patients With Pancreatic Cancer (2014)

These results suggest that serum LRG-1 is a promising biomarker for pancreatic cancer.
Effect of acetylcholine on in vitro IL-2 production and NK cell cytotoxicity of rats. (2004)

In the present study, we explored the effect of acetylcholine (ACh) on lymphocyte function and the receptor mechanisms mediating the effect. Concanavalin A (Con A)-induced interleukin-2 (IL-2) production and natural killer (NK) cell cytotoxicity were used to assess function of the T lymphocytes and the NK cells from rat spleens. Muscarinic ACh receptors (mA ChRs) agonist pilocarpine and antagonist atropine, as well as nicotinic ACh receptors (nAChRs) agonist nicotine and antagonist tubocurarine were used to determine the action pathways of ACh on T and NK cells. ACh at the concentrations of 10(-10) to 10(-8) M exerted an enhancing effect on Con A-induced IL-2 production and an inhibitory effect on NK cell cytotoxicity. Both pilocarpine and nicotine at the same doses as ACh could mimic these effects of ACh. The enhancing effect of ACh on IL-2 production could be blocked by either atropine or tubocurarine. But the inhibitory effect of ACh on NK cell cytotoxicity was abolished only by atropine, not by tubocurarine. These results suggest that ACh, which is a neurotransmitter of peripheral parasympathetic nervous system, can regulate function of T and NK cells, and the different regulatory effects of ACh on the two types of lymphocytes may be mediated by the different receptor mechanisms.
Viruses as Pest-Control Agents (1984)

Les baculovirus. Cultures cellulaires d'insectes. Caracterisation et identification des baculovirus. Classification et nomenclature; genetique; epizootiologie; securite; strategies de lutte contre les depredateurs a l'aide de virus; techniques de dissemination des virus; virus soumis a des evaluations et/ou en applications; applications sur le terrain; persistance; production de virus; perspectives
Fabrication of multilayered SU8 structure for terahertz waveguide with ultralow transmission loss (2014)

A microfabricated hollow air-filled waveguide with two back-to-back bends operating in the WR-3 frequency range of 220 to 325 GHz has been successfully fabricated through a multilayered ultrathick SU8 process and has ultralow transmission loss of 0.028 to 0.03 dB/mm in a performance test. This is the first SU8 constructed hollow waveguide operating at WR-3 frequencies having transmission loss comparable with the state-of-the-art computer numerical control (CNC) machined metal circuits. The multilayered SU8 processing technique has a great advantage of reducing the transmission loss by decreasing the probability of air gaps between SU8 layers. The excellent device performance is also attributed to the precisely controlled layer thickness and ultimately low surface roughness of evaporated silver which only contributes a small part of the microwave signal attenuation.
MIP-2 secreted by epithelial cells increases neutrophil and lymphocyte recruitment in the mouse intestine (2001)

These experiments are the first to show a functional role for epithelial chemokines in vivo and reveal an unexpected role for the neutrophil chemokine MIP-2 in controlling mucosal lymphocyte migration.
Synthesis of an Electromagnetic Wave Absorber for High-Speed Wireless Communication (2008)

Millimeter waves (30-300 GHz) are starting to be used in next generation high-speed wireless communications. To avoid electromagnetic interference in this wireless communication, finding a suitable electromagnetic wave absorber in the millimeter wave range is an urgent matter. In this work, we prepared a high-performance millimeter wave absorber composed of a series of aluminum-substituted epsilon-iron oxide, epsilon-Al(x)Fe(2-x)O(3), nanomagnets (0 < or = x < or = 0.40) with a particle size between 25 and 50 nm. The materials in this series have an orthorhombic crystal structure in the Pna2(1) space group, which has four nonequivalent Fe sites and Al ion that predominantly occupies the tetrahedral [FeO(4)] site. The field-cooled magnetization curves showed that the T(C) values were 448, 480, and 500 K for x = 0.40, 0.21, and 0, respectively. The magnetization versus external magnetic field showed that the coercive field H(c) values at 300 K were 10.2, 14.9, and 22.5 kOe for x = 0.40, 0.21, and 0, respectively. The millimeter wave absorption properties were measured at room temperature by terahertz time domain spectroscopy. The frequencies of the absorption peaks for x = 0.40, 0.30, 0.21, 0.09, 0.06, and 0 were observed at 112, 125, 145, 162, 172, and 182 GHz, respectively. These absorptions are due to the natural resonance achieved by the large magnetic anisotropies in this series. Such frequencies are the highest ones for magnetic materials. Because aluminum is the third most abundant atom, aluminum-substituted epsilon-iron oxide is very economical, and thus these materials are advantageous for industrial applications.
A simplified and sensitive fluorescent method for disaccharide analysis of both heparan sulfate and chondroitin/dermatan sulfates from biological samples (2008)

Sulfated glycosaminoglycans regulate the biological functions of a wide variety of proteins, primarily through high affinity interactions mediated by specific sugar sequences or patterns/densities of sulfation. Disaccharide analysis of such glycosaminoglycans yields important diagnostic and comparative structural information on sulfate patterning. When applied to specific oligosaccharides it can also make a vital contribution to sequence elucidation. Standard UV detection of lyase-generated disaccharides resolved by HPLC can lack sufficient sensitivity and be compromised by contaminating UV signals, when dealing with scarce tissue- or cell culture-derived material. Various methods exist for improved detection, but usually involve additional HPLC hardware and often necessitate different procedures for analyzing different glycosaminoglycans. We describe a simple procedure, requiring only standard HPLC instrumentation, involving prederivatization of disaccharides with 2-aminoacridone with no cleanup of samples, followed by a separation by reverse-phase HPLC that is sensitive to as little as approximately 100 pg (approximately 10(-13) mol) of an individual disaccharide, thereby allowing analyses of >10 ng of total glycosaminoglycan. Importantly, separate analysis of both HS/heparin and CS/DS species within a mixed glycosaminoglycan pool can be performed using the same procedure on a single column. We demonstrate its applicability in dealing with small quantities of material derived from rat liver (where we demonstrate a high abundance of the unusual CS-E species within the CS/DS pool) and MDCK cells (which revealed a HS species of relatively low N-sulfation, but high O-sulfation). This simplified method should find a widespread utility for analyzing glycosaminoglycans from limited animal and cell culture samples.
Nonlinear mapping of the luminance in dual-layer high dynamic range displays (2009)

It has long been known that the human visual system (HVS) has a nonlinear response to luminance. This nonlinearity can be quantified using the concept of <i>just noticeable difference</i> (JND), which represents the minimum amplitude of a specified test pattern an average observer can discern from a uniform background. The JND depends on the background luminance following a <i>threshold versus intensity</i> (TVI) function. It is possible to define a curve which maps physical luminances into a perceptually linearized domain. This mapping can be used to optimize a digital encoding, by minimizing the visibility of quantization noise. It is also commonly used in medical applications to display images adapting to the characteristics of the display device. High dynamic range (HDR) displays, which are beginning to appear on the market, can display luminance levels outside the range in which most standard mapping curves are defined. In particular, dual-layer LCD displays are able to extend the gamut of luminance offered by conventional liquid crystals towards the black region; in such areas suitable and HVS-compliant luminance transformations need to be determined. In this paper we propose a method, which is primarily targeted to the extension of the DICOM curve used in medical imaging, but also has a more general application. The method can be modified in order to compensate for the ambient light, which can be significantly greater than the black level of an HDR display and consequently reduce the visibility of the details in dark areas.
Facets for Discovery and Exploration in Text Collections (2011)

Faceted classifications of text collections provide a useful means of partitioning documents into related groups, however traditional approaches of faceting text collections rely on comprehensive analysis of the subject area or annotated general attributes. In this paper we show the application of basic principles for facet analysis to the development of computational methods for facet classification of text collections. Integration with a visual analytics system is described with summaries of user experiences.
Fluctuations in intraocular pressure and the potential effect on aberrations of the eye (2007)

Changes in intraocular pressure have no noticeable effect on image quality. This could be because the eye has a compensating mechanism to correct for any effect of ocular dynamics on corneal shape and refractive status. Such a mechanism may also affect the pattern of aberrations or it may be that aberrations alter in a way that offsets any potentially detrimental effects of intraocular pressure change on the retinal image. Variations in patterns of aberrations and how they may be related to ocular dynamics need to be investigated further before attempts at correction are made.
Amplification in Nonlinear Reactive Networks (1960)

Sufficient conditions for validity of the Manley-Rowe equations in a classical nonlinear reactive network are shown to be conservation of energy and proportionality of average power with frequency. It is shown by counter example that conservation of energy alone is insufficient. A sufficient condition for a quantum mechanical maser model is found to be equilibrium of state populations. In this case conservation of energy follows as a consequence from the equilibrium condition, but proportionality of power with frequency is not required.
Human Detection in Thermal Imaging Using YOLO (2019)

In this paper, we consider the problem of automatic detection of humans in thermal videos and images. The thermal videos are recorded on a meadow with a small forest with up to three persons present on the scene at different positions and ranges from the camera. To simulate realistic conditions that can happen during surveillance and monitoring of protected areas, all videos are recorded at night but different weather conditions--clear weather, rain, and fog. We present the results of human detection on a custom dataset of thermal videos using the out-of-the-box YOLO convolutional neural network and the YOLO network trained on a subset of our dataset. YOLO is an object detector pretrained on the COCO image dataset of RGB images of various object classes. Test experimental results have shown significantly improved performance of human detection in thermal imaging in terms of average precision for trained YOLO model over the original model.
Purification, characterization, and ontogeny of acetyl-CoA carboxylase isozyme of chick embryo brain. (1991)

Acetyl-CoA carboxylase catalyzes the first committed step in the synthesis of fatty acids. Because fatty acids are required during myelination in the developing brain, it was proposed that the level of acetyl-CoA carboxylase may be highest in embryonic brain. The presence of acetyl-CoA carboxylase activity was detected in chick embryo brain. Its activity varied with age, showing a peak in the 17-18-day-old embryo and decreasing thereafter. The enzyme, affinity-purified from 18-day-old chick embryo brain, appeared as a major protein band on polyacrylamide electrophoresis gels in the presence of sodium dodecyl sulfate (Mr 265,000), indistinguishable from the 265 kDa isozyme of liver acetyl-CoA carboxylase. It had significant activity (Sp act = 1.1 mumol/min per mg protein) in the absence of citrate. There was a maximum stimulation of only 25% in the presence of citrate. Dephosphorylation using [acetyl-CoA carboxylase] phosphatase 2 did not result in activation of the enzyme. Palmitoyl-CoA (0.1 mM) and malonyl-CoA (1 mM) inhibited the activity to 95% and 71%, respectively. Palmitoylcarnitine, however, did not show significant inhibition. The enzyme was inhibited (greater than 95%) by avidin; however, avidin did not show significant inhibition in the presence of excess biotin. The enzyme was also inhibited (greater than 90%) by antibodies against liver acetyl-CoA carboxylase. An immunoblot or avidin-blot detected only one protein band (Mr 265,000) in preparations from chick embryo brain or adult liver. These observations suggest that acetyl-CoA carboxylase is present in embryonic brain and that the enzyme appears to be similar to the 265 kDa isozyme of liver.
Current Laser Resurfacing Technologies: A Review that Delves Beneath the Surface (2012)

Numerous laser platforms exist that rejuvenate the skin by resurfacing its upper layers. In varying degrees, these lasers improve the appearance of lentigines and rhytides, eliminate photoaging, soften scarring due to acne and other causes, and treat dyspigmentation. Five major classes of dermatologic lasers are currently in common use: ablative and nonablative lasers in both fractionated and unfractionated forms as well as radiofrequency technologies. The gentler nonablative lasers allow for quicker healing, whereas harsher ablative lasers tend to be more effective. Fractionating either laser distributes the effect, increasing the number of treatments but minimizing downtime and complications. In this review article, the authors seek to inform surgeons about the current laser platforms available, clarify the differences between them, and thereby facilitate the identification of the most appropriate laser for their practice.
Pengaruh Pertumbuhan Ekonomi, Kemiskinan, Dan Belanja Daerah Terhadap Indeks Pembangunan Manusia Di Kabupaten Kota Provinsi Bali Periode 2005 – 2013 (2016)

In economic paradigm, there has been changing in measuring rod of economic succeed from economic growth approach to be human development approach.  The change has change back human as the processor and to be the capital in development.  Purpose of this research is to find out the influence of economic growth, poverty, and regional expenditure partially and simultaneously to Human Development in Bali Province Period of 2005 – 2013.  Data type used is the secondary data by using panel data method.  Data analysis technique used the multiple linear regression.  Research result shows that partially the economic growth variable has positive and significant influence to human development index in Bali Province period of 2005 – 2013, partially the poverty index has significant negative influence to human development index in Bali Province period of 2005 – 2013, and partially the Regional Expenditure variable has positive and significant influence to human development index in Bali Province period of 2005 – 2013. Simultaneously the variables of economic growth, poverty, and Regional Expenditure have significant influence to human development index in Bali Province period of 2005 – 2013.
Molecular biology of hair morphogenesis: Development and cycling (2003)

In mammals, hair follicles produce hairs that fulfill a number of functions including thermoregulation, collecting sensory information, protection against environmental trauma, social communication, and mimicry. Hair follicles develop as a result of epithelial-mesenchymal interactions between epidermal keratinocytes committed to hair-specific differentiation and cluster of dermal fibroblasts that form follicular papilla. During postnatal life, hair follicles show patterns of cyclic activity with periods of active growth and hair production (anagen), apoptosis-driven involution (catagen), and relative resting (telogen). During last decade, substantial progress has been achieved in delineating molecular mechanisms that control hair follicle development and cyclic activity. In this review, we summarize the data demonstrating that regulation of hair follicle development in the embryo and control of hair follicle growth during postnatal life are highly conserved and both require involvement of similar molecular mechanisms. Since many of the molecules that control hair follicle development and cycling are also involved in regulating morphogenesis and postnatal biology of other ectodermal derivatives, such as teeth, feathers, and mammary glands, basic principles and molecular mechanisms that govern hair follicle development and growth may also be applicable for other developmental systems.
Midkine and Pleiotrophin: Two Related Proteins Involved in Development, Survival, Inflammation and Tumorigenesis (2002)

Midkine (MK) and pleiotrophin (PTN) are low molecular weight proteins with closely related structures. They are mainly composed of two domains held by disulfide bridges, and there are three antiparallel beta-sheets in each domain. MK and PTN promote the growth, survival, and migration of various cells, and play roles in neurogenesis and epithelial mesenchymal interactions during organogenesis. A chondroitin sulfate proteoglycan, protein-tyrosine phosphatase zeta (PTPzeta), is a receptor for MK and PTN. The downstream signaling system includes ERK and PI3 kinase. MK binds to the chondroitin sulfate portion of PTPzeta with high affinity. Among the various chondroitin sulfate structures, the E unit, which has 4,6-disulfated N-acetylgalactosamine, provides the strongest binding site. The expression of MK and PTN is increased in various human tumors, making them promising as tumor markers and as targets for tumor therapy. MK and PTN expression also increases upon ischemic injury. MK enhances the migration of inflammatory cells, and is involved in neointima formation and renal injury following ischemia. MK is also interesting from the viewpoints of the treatment of neurodegenerative diseases, increasing the efficiency of in vitro development, and the prevention of HIV infection.
Comparison of DNA detection methods using nanoparticles and silver enhancement (2005)

DNA microarrays are an emerging technology for the parallel detection of DNA molecules. Fluorescent molecules are the current standard for a DNA array's optical readout but they possess some drawbacks including the stability of the dyes and the cost of the scanners. Therefore alternative labelling strategies are of considerable interests. One such strategy is the use of nanoparticles which offers several advantages in terms of stability and versatility of the detection mode. The authors present a review on the different ways DNA can be detected, mainly onto a solid support, using nanoparticle labels.
In vivo regulation of soluble cytokine-receptors by Infliximab and steroids in active Crohn’s Disease (2003)

info:eu-repo/semantics/published
Immunocytochemical Panel for the Identification of Malignant Cells in Serous Effusions (1991)

The cytologic diagnosis of malignancy in serous effusions can be challenging. An immunocytochemical (ICC) panel using commercially available antibodies (to carcinoembryonic antigen [CEA], epithelial membrane antigen [EMA], B72.3, Leu-M1, cytokeratin [CK], leukocyte common antigen [LCA], S-100 protein, and vimentin) was applied to cell blocks fixed in methyl Carnoy's solution that were from 55 consecutive pleural, peritoneal, and pericardial fluid specimens. The results were correlated with data from clinical records and routine cytologic studies. Final cytologic diagnoses included 26 of adenocarcinoma and 1 of mesothelioma. The remaining 28 cases were considered to be benign (reactive) proliferations. EMA, CEA, B72.3, and Leu-M1 were present in 96%, 77%, 58%, and 42% of adenocarcinomas, respectively. These determinants were absent in the mesothelioma and the reactive effusions, although anti-CEA yielded strong background staining of inflammatory cells. The CK markers identified malignant cells in 93% of cases, but consistently stained mesothelial cells as well. Antivimentin strongly labeled mesothelial cells in all cases, with weak to absent staining of malignant cells. In 3 of 26 carcinoma cases (12%), the ICC panel identified malignant cells that were not recognized initially on routine cytologic examination. In 1 of 26 cases (4%), the panel was falsely negative. Use of this approach can improve the diagnostic accuracy of cytologic examination of serous fluids. The ICC panel is especially helpful when atypical mesothelial proliferation is present, or in cases that are clinically suspect for malignancy, but cytologically negative because there are only a few malignant cells, or those that are cytologically bland.