gebhart/patrepeval huggingface dataset:
Modeling the effects of delayed haptic and visual feedback in a collaborative virtual environment (2007)

Collaborative virtual environments (CVEs) enable two or more people, separated in the real world, to share the same virtual “space.” They can be used for many purposes, from teleconferencing to training people to perform assembly tasks. Unfortunately, the effectiveness of CVEs is compromised by one major problem: the delay that exists in the networks linking users together. Whilst we have a good understanding, especially in the visual modality, of how users are affected by delayed feedback from their own actions, little research has systematically examined how users are affected by delayed feedback from other people, particularly in environments that support haptic (force) feedback. The current study addresses this issue by quantifying how increasing levels of latency affect visual and haptic feedback in a collaborative target acquisition task. Our results demonstrate that haptic feedback in particular is very sensitive to low levels of delay. Whilst latency affects visual feedback from 50 ms, it impacts on haptic task performance 25 ms earlier, and causes the haptic measures of performance deterioration to rise far more steeply than visual. The “impact-perceive-adapt” model of user performance, which considers the interaction between performance measures, perception of latency, and the breakdown of perception of immediate causality, is proposed as an explanation for the observed pattern of performance.
A Study on Polynomial Regression and Gaussian Process Global Surrogate Model in Hierarchical Surrogate-Assisted Evolutionary Algorithm (2005)

This paper presents a study on hierarchical surrogate-assisted evolutionary algorithm (HSAEA) using different global surrogate models for solving computationally expensive optimization problems. In particular, we consider the use of Gaussian process (GP) and polynomial regression (PR) methods for approximating the global fitness landscape in the surrogate-assisted evolutionary search. The global surrogate model serves to pre-screen the EA population for promising individuals. Subsequently, these potential individuals undergo a local search in the form of Lamarckian learning using online local surrogate models. Numerical results are presented on two multimodal benchmark test functions. The results obtained show that both PR-HSAEA and GP-HSAEA converge to good designs on a limited computational budget. Further, our study also shows that the GP model is suitable for global surrogate modeling in HSAEA if the evaluation function is very expensive in computations. On moderately expensive problems, the PR method may serve to generate better efficiency than using GP.
Two Vitamin D Response Elements Function in the Rat 1,25-Dihydroxyvitamin D 24-Hydroxylase Promoter (1995)

The interaction between the two vitamin D response elements (DRE) located at -154 to -134 base pairs (bp) and -262 to -238 bp from the transcription initiation site has been studied using reporter gene assays and binding assays by electrophoretic gel shift measurements. 3 half-sites separated by 3 bp were found necessary for transactivation by the -154 to -125 DRE, while 2 half-sites separated by 3 bp were needed for the DRE at -262 to -238 to function. However, the two DREs together provided maximal activity. The 93-bp fragment separating the two DREs was not required and could be deleted. The most effective binding by receptor was found with the two complete DREs (dissociation constant (Kd) = 13.7 pM), although each DRE bound to the receptor and nuclear accessory factor with about 5 nM Kd. The two DREs (a total of 5 half-sites) apparently account for most if not all of the transactivation of the rat 24-hydroxylase by 1,25-dihydroxyvitamin D3. This system represents the most powerful of the DREs reported to date.
IVIG – mechanisms of action (2003)

Intravenous immunoglobulin (IVIG) preparations are fractionated from a plasma pool of several thousand donors. IVIG contain immune antibodies and physiologic autoantibodies. Immune antibodies reflect the immunologic experience of the donor population. This fraction of IVIG preparations is useful for replacement therapy and passive immunisation. Natural autoantibodies are able to react with the immune system of the recipient of IVIG and are suggested to help to correct immune deregulation. Immunomodulatory and anti-inflammatory properties are based on multiple mechanisms of action which are described. These mechanisms are effective concomitantly and synergistically at every occasion of use of IVIG in inflammatory and autoimmune disorders.
Mode of action of fibronectin in promoting chicken myoblast attachment. Mr = 60,000 gelatin-binding fragment binds native fibronectin. (1981)

The abbreviations used are: NaCI/Pi, 150 mM NaCl and 10 mM NaHPOn/Na,HPO.,, pH 7.0 SDS, sodium dodecyl sulfate.
Structural Properties of Lithium Thio-Germanate Thin Film Electrolytes Grown by Radio Frequency Sputtering (2011)

In this study, lithium thio-germanate thin film electrolytes have been successfully prepared by radio frequency (RF) magnetron sputtering deposition in Ar gas atmospheres. The targets for RF sputtering were prepared by milling and pressing appropriate amounts of the melt-quenched starting materials in the nLi(2)S + GeS(2) (n = 1, 2, and 3) binary system. Approximately 1 μm thin films were grown on Ni coated Si (Ni/Si) substrates and pressed CsI pellets using 50 W power and 25 mtorr (∼3.3 Pa) Ar gas pressures to prepare samples for Raman and Infrared (IR) spectroscopy, respectively. To improve the adhesion between the silicon substrate and the thin film electrolyte, a sputtered Ni layer (∼120 nm) was used. The surface morphologies and thickness of the thin films were determined by field emission scanning electron microscopy (FE-SEM). The structural properties of the starting materials, target materials, and the grown thin films were examined by X-ray diffraction (XRD), Raman, and IR spectroscopy.
Home health, nursing homes take patients from hospitals. (1994)

The fast-growing home health agencies and nursing homes are taking acute and subacute patients from the nation's hospitals, but their labor costs are soaring. And personnel problems may slow their growth, writes Donald E.L. Johnson
SpoofKiller: You Can Teach People How to Pay, but Not How to Pay Attention (2012)

We describe a novel approach to reduce the impact of spoofing by a subtle change in the login process. At the heart of our contribution is the understanding that current antispoof technologies fail largely as a result of the difficulties to communicate security and risk to typical users. Accordingly, our solution is oblivious to whether the user was tricked by a fraudster or not. We achieve that by modifying the user login process, and letting the browser or operating system cause different results of user login requests, based on whether the site is trusted or not. Experimental results indicate that our new approach, which we dub "SpoofKiller", will address approximately 80% of spoofing attempts.
Fas ligand deficiency in HIV disease (1997)

Apoptosis is postulated to be involved as an anti-viral immune mechanism by killing infected cells before viral replication has occurred. The Fas-Fas ligand interaction is a powerful regulator of T cell apoptosis and could potentially act as a potent anti-viral immune mechanism against T cell tropic virus such as human immunodeficiency virus (HIV). We investigated the status of Fas ligand in peripheral blood mononuclear cells (PBMCs) obtained from persons infected with HIV. We found that monocytes in freshly isolated PBMCs from healthy individuals possess cell surface Fas ligand. In contrast, monocytes in freshly isolated PBMCs from HIV-infected patients had no detectable Fas ligand on the cell surface. Consistent with these findings of surface expression, Fas ligand activity was deficient in the cells from HIV-infected persons. The effect of replacing Fas ligand activity on HIV production by patients' cells was assessed in an in vitro assay. The addition of a functional anti-Fas antibody to PBMCs from HIV-infected individuals inhibited viral production by greater than 90% without affecting lymphocytic function. These findings suggest the possibility of a new therapeutic modality for the treatment of HIV-infected individuals based on the reconstitution of Fas ligand activity.
Bacterial Cell-to-Cell Communication (2006)

Many bacterial diseases are caused by organisms growing together as communities or biofilms. These microorganisms have the capacity to coordinately regulate specific sets of genes by sensing and communicating amongst themselves utilizing a variety of signals. This book examines the mechanisms of quorum sensing and cell-to-cell communication in bacteria and the roles that these processes play in regulating virulence, bacterial interactions with host tissues, and microbial development. Recent studies suggest that microbial cell-to-cell communication plays an important role in the pathogenesis of a variety of disease processes. Furthermore, some bacterial signal molecules may possess immunomodulatory activity. Thus, understanding the mechanisms and outcomes of bacterial cell-to-cell communication has important implications for appreciating host-pathogen interactions and ultimately may provide new targets for antimicrobial therapies that block or interfere with these communication networks.
Allele-specific silencing of dominant disease genes (2003)

Small interfering RNA (siRNA) holds therapeutic promise for silencing dominantly acting disease genes, particularly if mutant alleles can be targeted selectively. In mammalian cell models we demonstrate that allele-specific silencing of disease genes with siRNA can be achieved by targeting either a linked single-nucleotide polymorphism (SNP) or the disease mutation directly. For a polyglutamine neurodegenerative disorder in which we first determined that selective targeting of the disease-causing CAG repeat is not possible, we took advantage of an associated SNP to generate siRNA that exclusively silenced the mutant Machado-Joseph disease/spinocerebellar ataxia type 3 allele while sparing expression of the WT allele. Allele-specific suppression was accomplished with all three approaches currently used to deliver siRNA: in vitro-synthesized duplexes as well as plasmid and viral expression of short hairpin RNA. We further optimized siRNA to specifically target a missense Tau mutation, V337M, that causes frontotemporal dementia. These studies establish that siRNA can be engineered to silence disease genes differing by a single nucleotide and highlight a key role for SNPs in extending the utility of siRNA in dominantly inherited disorders.
CHROMOSOME PARTITIONING IN BACTERIA (1995)

This review addresses chromosome partitioning in Escherichia coli and Bacillus subtilis. The first part deals with events associated with completion of a round of replication to an extent that yields separable chromosomes. Events more directly involved in chromosome movement are covered in the second part. In the final section, a model for chromosome partitioning based on the information presented in the first two parts is presented.
Bimorphinans as highly selective, potent .kappa. opioid receptor antagonists (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBimorphinans as highly selective, potent .kappa. opioid receptor antagonistsP. S. Portoghese, A. W. Lipkowski, and A. E. TakemoriCite this: J. Med. Chem. 1987, 30, 2, 238–239Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February 1987https://pubs.acs.org/doi/10.1021/jm00385a002https://doi.org/10.1021/jm00385a002research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Regulation of major histocompatibility complex class II synthesis by interleukin‐10 (2002)

We have shown previously that interleukin-10 (IL-10) blocks the development and T-cell stimulatory capacity of human monocyte-derived dendritic cells, without apparently down-regulating the surface expression of co-stimulatory molecules or human leucocyte antigen (HLA) molecules. In the majority of donors (60%), the cell surface levels of HLA-DR actually increased upon IL-10 treatment. Here we have shown that IL-10 does not regulate HLA-DR transcription as assessed by polymerase chain reation. Epifluorescence microscopy analysis showed that IL-10 primarily increased the intracellular pool of HLA-DR. In fact, IL-10 directly increased HLA-DR protein synthesis. However, IL-10 did not significantly alter the synthesis of invariant chain (Ii), which plays a crucial role in the assembly, transport and loading of newly formed HLA class II molecules, nor the amount of Ii reaching the cell-surface. In contrast, IL-10 increased the amount of HLA-DR-bound Iip33 shortly after the HLA-DR complex assembly. We postulate that, upon IL-10 treatment, immature Ii-associated HLA II molecules can still transit to the cell surface as they do in immature dendritic cells and recycle to the intracellular space, where they accumulate. A higher proportion of Ii-associated HLA-DR, coupled to increased membrane recycling, may contribute to the lower T-cell stimulatory capacity of IL-10-treated dendritic cells.
Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems (2006)

On the basis of task-related imaging studies in normal human subjects, it has been suggested that two attention systems exist in the human brain: a bilateral dorsal attention system involved in top-down orienting of attention and a right-lateralized ventral attention system involved in reorienting attention in response to salient sensory stimuli. An important question is whether this functional organization emerges only in response to external attentional demands or is represented more fundamentally in the internal dynamics of brain activity. To address this question, we examine correlations in spontaneous fluctuations of the functional MRI blood oxygen level-dependent signal in the absence of task, stimuli, or explicit attentional demands. We identify a bilateral dorsal attention system and a right-lateralized ventral attention system solely on the basis of spontaneous activity. Further, we observe regions in the prefrontal cortex correlated with both systems, a potential mechanism for mediating the functional interaction between systems. These findings demonstrate that the neuroanatomical substrates of human attention persist in the absence of external events, reflected in the correlation structure of spontaneous activity.
Qualitative simulation of mechanisms (1985)

Qualitative simulation is a key inference process in qualitative causal reasoning. However, the precise meaning of the different proposals and their relation with differential equations is often unclear. In this paper, we present a precise definition of qualitative structure and behavior descriptions as abstractions of differential equations and continuously differentiable functions. We present a new algorithm for qualitative simulation that generalizes the best features of existing algorithms, and allows direct comparisons among alternate approaches. Starting with a structural description abstracted from a differential equation, we prove that the QSIM algorithm is guaranteed to produce a qualitative behavior corresponding to any solution to the original equation. We also show that any qualitative simulation algorithm, because of its local point of view, will sometimes produce spurious qualitative behaviors: ones which do not correspond to any mechanism satisfying the structureal description. These observations suggest specific types of care that must be taken in designing applications of qualitative causal reasoning systems, and in constructing and validating a knowledge base of mechanism descriptions.
Bioinformatics (2003)

The writer T.S. Eliot once mused, “Where is the knowledge we have lost in information?” [1 ]. From a biological perspective, the answer to this profound question is today having far-reaching consequences for the future of biomedical research and, in particular, the drug discovery process.
Optimum Global Transmitter Power Control in Cellular Radio Systems (2005)

Transmitter power control as a method to reduce cochannel interference for a given channel allocation is investigated. The performance is analyzed in terms of interference. (outage) probabilities. Qpthm and nearoptimum global power control schemes are proposed. Using these schemes upper bounds on the performance of power control schemes are derived. Numerical results indicate that these upper bounds exceed the performance of conventional systems by an order of magnitude in interference suppression and by a factor of 5 in capacity. The structure of the optimum algorithm shows that efficient power control and dynamic channel assignment algorithms should be closely related.
Molecular Characterization of the Salutaridinol 7-O-Acetyltransferase Involved in Morphine Biosynthesis in Opium Poppy Papaver somniferum (2001)

Salutaridinol 7-O-acetyltransferase (EC ) catalyzes the conversion of the phenanthrene alkaloid salutaridinol to salutaridinol-7-O-acetate, the immediate precursor of thebaine along the morphine biosynthetic pathway. We have isolated a cDNA clone that corresponds to the internal amino acid sequences of the native enzyme purified from a cell suspension culture of opium poppy Papaver somniferum. The recombinant enzyme acetylated the 7-hydroxyl moiety of salutaridinol in the presence of acetyl-CoA. The apparent K(m) value for salutaridinol was determined to be 9 microm and 54 microm for acetyl-CoA. The gene transcript was detected in extracts from Papaver orientale and Papaver bracteatum in addition to P. somniferum. Genomic DNA gel blot analysis indicated that there is likely a single copy of this gene in the P. somniferum genome. The amino acid sequence of salutaridinol 7-O-acetyltransferase is most similar (37% identity) to that of deacetylvindoline acetyltransferase of Catharanthus roseus. Salutaridinol 7-O-acetyltransferase is the second enzyme specific to morphine biosynthesis for which we have isolated a cDNA. Taken together with the other cDNAs cloned encoding norcoclaurine 6-O-methyltransferase, (S)-N-methylcoclaurine 3'-hydroxylase, the cytochrome P-450 reductase, and codeinone reductase, significant progress has been made toward accumulating genes of this pathway to enable the end goal of a biotechnological production of morphinan alkaloids.
The Best of Times, the Worst of Times (2000)

The recent tragic death of a young gene therapy patient has marred the field of gene therapy research. Yet, as [Anderson][1] explains in a Perspective, encouraging new results from a study in which a severe immunodeficiency disease is corrected in two infants by delivery of the defective gene ([ Cavazzana-Calvo et al .][2]) have brought cautious optimism back to the gene therapy field.

 [1]: http://www.sciencemag.org/cgi/content/full/288/5466/627
 [2]: http://www.sciencemag.org/cgi/content/full/288/5466/669
Treatment of Terminal Peritoneal Carcinomatosis by a Transducible p53-Activating Peptide (2004)

Advanced-stage peritoneal carcinomatosis is resistant to current chemotherapy treatment and, in the case of metastatic ovarian cancer, results in a devastating 15%-20% survival rate. Therapeutics that restore genes inactivated during oncogenesis are predicted to be more potent and specific than current therapies. Experiments with viral vectors have demonstrated the theoretical utility of expressing the p53 tumor suppressor gene in cancer cells. However, clinically useful alternative approaches for introducing p53 activity into cancer cells are clearly needed. It has been hypothesized that direct reactivation of endogenous p53 protein in cancer cells will be therapeutically beneficial, but few tests of this hypothesis have been carried out in vivo. We report that a transducible D-isomer RI-TATp53C' peptide activates the p53 protein in cancer cells, but not normal cells. RI-TATp53C' peptide treatment of preclinical terminal peritoneal carcinomatosis and peritoneal lymphoma models results in significant increases in lifespan (greater than 6-fold) and the generation of disease-free animals. These proof-of-concept observations show that specific activation of endogenous p53 activity by a macromolecular agent is therapeutically effective in preclinical models of terminal human malignancy. Our results suggest that TAT-mediated transduction may be a useful strategy for the therapeutic delivery of large tumor suppressor molecules to malignant cells in vivo.
Mass Production Of Fused Couplers And Coupler Based Devices (1986)

An automatable mass production system capable of manufacturing low loss (less than 0.1 dB) fused single mode fiber optic couplers at a rate in excess of 30,000 pieces per work station year has been developed. The design requirements and limitations observed in the initial development of a manual version of this system are discussed. Integration of users optical and mechanical requirements, optical fiber design, and coupler manufacturing tooling is an important goal in the effort to reduce costs to large volume users.
Hydrido and chloro gallium and aluminium complexes with the tridentate bis(2-dimethylaminoethyl)amide ligand (2006)

Five-coordinate gallium and aluminium dihydrides, H2Ga[N(CH2CH2NMe2)2] () and H2Al[N(CH2CH2NMe2)2] (), were synthesized and found to be volatile and thermally stable. and reacted with H3Ga(NMe3) and H3Al(NMe3), respectively, to form H2Ga[N(CH2CH2NMe2)2]GaH3 () and H2Al[N(CH2CH2NMe2)2]AlH3 (), in which the amido nitrogen bridged between the MH2 and MH3 groups (M=Ga or Al). A mixed metal complex, H2Al[N(CH2CH2NMe2)2]GaH3 () was obtained from the reaction of with H3Al(NMe3) or with H3Ga(NMe3), and a crystal consisting of a mixture of and was structurally characterized. The five-coordinate chloro derivative, Cl2Ga[N(CH2CH2NMe2)2] (), was synthesized and characterized.