gebhart/patrepeval huggingface dataset:
Automatic calibration of trigger delay time for cardiac MRI (2014)

This study aimed to automatically identify the cardiac rest period using a rapid free-breathing (FB) calibration scanning procedure, and to determine the optimal trigger delay for cardiac imaging. A standard deviation (SD) method was used to rapidly identify cardiac quiescent phases employing multiphase cine cardiac images. The accuracy of this method was investigated using 46 datasets acquired from 22 healthy volunteers. The possibility of using a low-resolution FB method to rapidly acquire cine images was also evaluated. The reproducibility and accuracy of the trigger delay obtained using the rapid calibration scanning process were assessed before its application to a real-time feedback system. The real-time trigger delay calibration system was then used to perform T1 -weighted, short-axis imaging at the end of the cardiac systolic period. Linear regression analysis of the trigger times obtained using the SD method and a reference method indicated that the SD algorithm accurately identified the cardiac rest period (linear regression: slope = 0.94-1, R(2) = 0.68-0.84). Group analysis showed that the number of pixels in the left ventricular blood pool in images acquired at the end-systolic time calculated in real time was significantly lower than in those acquired 50 ms in advance or later (p < 0.01, paired t-test). The low-resolution FB imaging method was reproducible for the calibration scanning of an image in a vertical long-axis slice position (average SD of trigger times, 16-39 ms). Combined with rapid FB calibration scanning, the real-time feedback system accurately adjusted the trigger delay for T1 -weighted short-axis imaging. The real-time feedback method is rapid and reliable for trigger time calibration, and could facilitate cardiac imaging during routine examination.
Facet development during platinum nanocube growth (2014)

An understanding of how facets of a nanocrystal develop is critical for controlling nanocrystal shape and designing novel functional materials. However, the atomic pathways of nanocrystal facet development are mostly unknown because of the lack of direct observation. We report the imaging of platinum nanocube growth in a liquid cell using transmission electron microscopy with high spatial and temporal resolution. The growth rates of all low index facets are similar until the {100} facets stop growth. The continuous growth of the rest facets leads to a nanocube. Our calculation shows that the much lower ligand mobility on the {100} facets is responsible for the arresting of {100} growing facets. These findings shed light on nanocrystal shape-control mechanisms and future design of nanomaterials.
Semi-autonomous, context-aware, agent using behaviour modelling and reputation systems to authorize data operation in the Internet of Things (2014)

In this paper we address the issue of gathering the “informed consent” of an end user in the Internet of Things. We start by evaluating the legal importance and some of the problems linked with this notion of informed consent in the specific context of the Internet of Things. From this assessment we propose an approach based on a semi-autonomous, rule based agent that centralize all authorization decisions on the personal data of a user and that is able to take decision on his behalf. We complete this initial agent by integrating context-awareness, behavior modeling and community based reputation system in the algorithm of the agent. The resulting system is a “smart” application, the “privacy butler” that can handle data operations on behalf of the end-user while keeping the user in control. We finally discuss some of the potential problems and improvements of the system.
Hydrogenation of Basic Nitriles with Raney Nickel (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogenation of Basic Nitriles with Raney NickelWolfgang HuberCite this: J. Am. Chem. Soc. 1944, 66, 6, 876–879Publication Date (Print):June 1, 1944Publication History Published online1 May 2002Published inissue 1 June 1944https://pubs.acs.org/doi/10.1021/ja01234a009https://doi.org/10.1021/ja01234a009research-articleACS PublicationsRequest reuse permissionsArticle Views2083Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A STED microscope aligned by design (2009)

STED microscopes are commonly built using separate optical paths for the excitation and the STED beam. As a result, the beams must be co-aligned and can be subject to mechanical drift. Here, we present a single-path STED microscope whose beams are aligned by design and hence is insensitive to mechanical drift. The design of a phase plate is described which selectively modulates the STED beam but leaves the excitation beam unaffected. The performance of the single-beam setup is on par with previous dual-beam designs.
Sepsis associated with transfusion of red cells contaminated with <i>Yersinia enterocolitica</i> (1990)

Between April 1987 and May 1989, the Centers for Disease Control investigated seven cases of transfusion-associated Yersinia enterocolitica sepsis; four were caused by organisms of serotype O:3, and one each was caused by organisms of serotype O:1,2,3; O:5,27; and O:20. All seven recipients developed septic shock after receiving units of red cells (RBCs) contaminated with Y. enterocolitica; five recipients died. The cases occurred in seven states and were unrelated. There was no evidence for contamination of the RBC units during processing. Six of the seven donors had serologic evidence of recent Y. enterocolitica infection, and it is hypothesized that these donors had asymptomatic bacteremia when they donated the implicated blood. Four of the seven donors reported gastrointestinal illness in the 4 weeks before blood donation, and one donor became ill on the day he donated blood. Y. enterocolitica grows well at 4 degrees C and in the presence of dextrose and iron. If blood is contaminated at the time of collection, storage of the RBCs at 4 degrees C provides an ideal environment for bacterial growth and endotoxin production. These cases demonstrate the need for careful evaluation of patients with transfusion reactions for possible sepsis and suggest a need to screen prospective blood donors for mild gastrointestinal illness, including those illnesses not requiring physician evaluation or medication.
Reduction of Skin Effect Losses by the Use of Laminated Conductors (1951)

It has recently been discovered that it is possible to reduce skin effect losses in transmission lines by properly laminating the conductors and adjusting the velocity of transmission of the waves. The theory for such laminated transmission lines is presented in the case of planar systems for both infinitesimally thin laminae and laminae of finite thickness. A transmission line completely filled with laminated material is discussed. An analysis is given of the modes of transmission in a laminated line, and of the problem of terminating such a line.
First report of intramyocardial pH in man. II. Assessment of adequacy of myocardial preservation. (1983)

Intramyocardial pH and temperature were continuously measured in the anteroseptal region in 40 patients undergoing aortic cross-clamping during cardiac operations. Myocardial protection was achieved with systemic cooling (25 degrees C) and multidose potassium cardioplegia (4 degrees C). A clinical myocardial preservation score was devised based on intraoperative and postoperative need for inotropic support, postoperative creatine kinase isoenzyme (CK-MB) and electrocardiographic changes, and radionuclide ventriculography. The patients were divided into three groups according to their preservation scores. Group I (n = 17) with good preservation (scores 0 to 2), Group II (n = 15) with fair preservation (scores 3 to 8), and Group III (n = 8) with poor preservation (scores 9 to 15). Baseline intramyocardial pH was similar in all groups (mean +/- SEM = 6.77 +/- 0.03). With the administration of cold potassium cardioplegia, intramyocardial pH rose above baseline in all three groups. The magnitude of this rise related directly to the adequacy of preservation and to the duration of the cross-clamp period. Patients with lowest preservation scores and shortest cross-clamp periods had the highest intramyocardial pH. In contrast, there was no relationship between myocardial temperature during cross-clamp and either intramyocardial pH or the preservation score. The integrated mean intramyocardial pH during cross-clamp was found to be the parameter that correlated most with the adequacy of preservation. The correlation between intramyocardial pH and myocardial temperature during the period of cross-clamping related to the length of this period; it was good (r = 0.76, p less than 0.01) in periods of 40 minutes or less and very poor in periods exceeding 60 minutes (r = 0.27, p greater than 0.10). It is concluded that (1) the magnitude of rise in intramyocardial pH during the period of aortic cross-clamping is a good indicator of the adequacy of myocardial preservation; (2) during periods of aortic cross-clamping exceeding 40 minutes, myocardial temperature is a poor indicator of adequacy of preservation, since progressive tissue acidosis may occur despite low myocardial temperatures; and (3) techniques and solutions that can effectively reduce the progression of tissue acidosis will, in most likelihood, enhance our ability to protect the ischemic myocardium during cardioplegic arrest.
Decitabine improves patient outcomes in myelodysplastic syndromes (2006)

Decitabine was found to be clinically effective in the treatment of patients with MDS, provided durable responses, and improved time to AML transformation or death. The duration of decitabine therapy may improve these results further.
Memorability of Image Regions (2012)

While long term human visual memory can store a remarkable amount of visual information, it tends to degrade over time. Recent works have shown that image memorability is an intrinsic property of an image that can be reliably estimated using state-of-the-art image features and machine learning algorithms. However, the class of features and image information that is forgotten has not been explored yet. In this work, we propose a probabilistic framework that models how and which local regions from an image may be forgotten using a data-driven approach that combines local and global images features. The model automatically discovers memorability maps of individual images without any human annotation. We incorporate multiple image region attributes in our algorithm, leading to improved memorability prediction of images as compared to previous works. 1
Therapeutic Intervention Scoring System (1983)

The Therapeutic Intervention Scoring System (TISS) introduced in 1974 has become a widely accepted method of classifying critically ill patients. In response to requests to update the system because of recent innovations in critical care, some items have been deleted, some have been added, and certain point scores have been adjusted. Explanations of items within the system and guidelines for the user are included. A comparison of the new 1983 system to the old 1974 system in 100 consecutive patients reveals no difference in total point scores. We hope this updated explanation will ease the task of assessing use of intensive care services.
Executing parallel TwigStack algorithm on a multi-core system (2009)

The advancement of multi-core processors technology has led to changing course of computing and enabled us to maximize the computing performance. In this study, we present a parallel TwigStack algorithm executed on a shared-memory multi-core system for achieving scalable query performance against large XML data. Our proposed scheme explores the following features. Firstly, we perform on-the-fly partitioning on input streams of XML nodes for subsequent parallel execution and, thereby, ensure that query solutions in a partition can be obtained by the TwigStack algorithm without being dependent on other partitions. Secondly, we propose a scheme for estimating the optimal partition size for a given system configuration by taking L2-cache size into account. Finally, we introduce a partition prefetching technique to alleviate the overheads of performing the on-the-fly partitions. The experimental results demonstrate that our proposed parallel algorithm works effectively and efficiently. The parallel speedup scales up to the number of available CPU-cores.
A Hybrid Approach Based on Genetic Algorithms in Conjunction with Statistical Methods for the Diagnosis of Breast Cancer (2006)

This chapter reviews and presents genetic algorithms and statistical methods based approach for early detection and classification of breast cancer using digital mammography. A feature selection using genetic algorithms and statistical methods has been investigated and presented. Genetic algorithms and statistical methods have been combined and a hybrid system has been developed and tested on a benchmark database. A comparative analysis of the results is included in this chapter.
Tetratricopeptide Repeat Motif-mediated Hsc70-mSTI1 Interaction (2003)

Murine stress-inducible protein 1 (mSTI1) is a co-chaperone that is homologous with the human Hsp70/Hsp90-organizing protein (Hop). Guided by Hop structural data and sequence alignment analyses, we have used site-directed mutagenesis, co-precipitation assays, circular dichroism spectroscopy, steady-state fluorescence, and surface plasmon resonance spectroscopy to both qualitatively and quantitatively characterize the contacts necessary for the N-terminal tetratricopeptide repeat domain (TPR1) of mSTI1 to bind to heat shock cognate protein 70 (Hsc70) and to discriminate between Hsc70 and Hsp90. We have shown that substitutions in the first TPR motif of Lys(8) or Asn(12) did not affect binding of mSTI1 to Hsc70, whereas double substitution of these residues abrogated binding. A substitution in the second TPR motif of Asn(43) lowered but did not abrogate binding. Similarly, a deletion in the second TPR motif coupled with a substitution of Lys(8) or Asn(12) reduced but did not abrogate binding. These results suggest that mSTI1-Hsc70 interaction requires a network of interactions not only between charged residues in the TPR1 domain of mSTI1 and the EEVD motif of Hsc70 but also outside the TPR domain. We propose that the electrostatic interactions in the first TPR motif made by Lys(8) or Asn(12) define part of the minimum interactions required for successful mSTI1-Hsc70 interaction. Using a truncated derivative of mSTI1 incapable of binding to Hsp90, we substituted residues on TPR1 potentially involved in hydrophobic contacts with Hsc70. The modified protein had reduced binding to Hsc70 but now showed significant binding capacity for Hsp90. In contrast, topologically equivalent substitutions on a truncated derivative of mSTI1 incapable of binding to Hsc70 did not confer Hsc70 specificity on TPR2A. Our results suggest that binding of Hsc70 to TPR1 is more specific than binding of Hsp90 to TPR2A with serious implications for the mechanisms of mSTI1 interactions with Hsc70 and Hsp90 in vivo.
Rapid natural scene categorization in the near absence of attention (2002)

What can we see when we do not pay attention? It is well known that we can be "blind" even to major aspects of natural scenes when we attend elsewhere. The only tasks that do not need attention appear to be carried out in the early stages of the visual system. Contrary to this common belief, we report that subjects can rapidly detect animals or vehicles in briefly presented novel natural scenes while simultaneously performing another attentionally demanding task. By comparison, they are unable to discriminate large T's from L's, or bisected two-color disks from their mirror images under the same conditions. We conclude that some visual tasks associated with "high-level" cortical areas may proceed in the near absence of attention.
A Complete Phase-Locked Loop Power Consumption Model (2002)

Summary form only given. A PLL power model that accurately estimates the power consumption during both lock and acquisition states is presented. The model is within 5% of circuit level simulation (SPICE) values. No significant power overhead (+/-5% of the power consumed at the final frequency) is incurred during the acquisition process.
Analysis of glycoprotein oligosaccharides using high-pH anion exchange chromatography (1991)

The natural heterogeneity of glycoprotein glycans requires that chromatography be an essential part of structural elucidation. The isomeric nature of oligosaccharide structure requires chromatography which is selective for not only composition, size and anomerity, but also ring substitutions and branching configurations. HPAEC is sensitive to these structural features and thus, has become an important new method for understanding the elusive function of glycoprotein glycans.
On the capacity of cooperative diversity systems with adaptive modulation (2005)

In recent years, cooperative diversity systems have gained increased attention in the literature as a new way of combating the effect of signal fading. In this paper, we investigate the performance of these systems when adaptive modulation is used. More specifically, we consider the case of optimal instantaneous power and rate adaptation, optimal power adaptation with constant power, and truncated channel inversion adaptation, and study the performance of both regenerative and non-regenerative systems under Rayleigh type of fading. The performance criteria used is the channel capacity which is the maximum rate of data transmission at an arbitrarily small bit error rate.
Does Histidine 332 of the D1 Polypeptide Ligate the Manganese Cluster in Photosystem II? An Electron Spin Echo Envelope Modulation Study (2001)

The tetranuclear manganese cluster in photosystem II is ligated by one or more histidine residues, as shown by an electron spin echo envelope modulation (ESEEM) study conducted with [(15)N]histidine-labeled photosystem II particles isolated from the cyanobacterium Synechocystis sp. strain PCC 6803 [Tang, X.-S., Diner, B. A., Larsen, B. S., Gilchrist, M. L., Jr., Lorigan, G. A., and Britt, R. D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 704-708]. One of these residues may be His332 of the D1 polypeptide. Photosystem II particles isolated from the Synechocystis mutant D1-H332E exhibit an altered S(2) state multiline EPR signal that has more hyperfine lines and narrower splittings than the corresponding signal in wild-type PSII particles [Debus, R. J., Campbell, K. A., Peloquin, J. M., Pham, D. P., and Britt, R. D. (2000) Biochemistry 39, 470-478]. These D1-H332E PSII particles are also unable to advance beyond an altered S(2)Y(Z)(*) state, and the quantum yield for forming the S(2) state is very low, corresponding to an 8000-fold slowing of the rate of Mn oxidation by Y(Z)(*). These observations are consistent with His332 being close to the Mn cluster and modulating the redox properties of both the Mn cluster and tyrosine Y(Z). To determine if D1-His332 ligates the Mn cluster, we have conducted an ESEEM study of D1-H332E PSII particles. The histidyl nitrogen modulation observed near 5 MHz in ESEEM spectra of the S(2) state multiline EPR signal of wild-type PSII particles is substantially diminished in D1-H332E PSII particles. This result is consistent with ligation of the Mn cluster by D1-His332. However, alternate explanations are possible. These are presented and discussed.
<i>FMR1</i> Protein: Conserved RNP Family Domains and Selective RNA Binding (1993)

Fragile X syndrome is the result of transcriptional suppression of the gene FMR1 as a result of a trinucleotide repeat expansion mutation. The normal function of the FMR1 protein (FMRP) and the mechanism by which its absence leads to mental retardation are unknown. Ribonucleoprotein particle (RNP) domains were identified within FMRP, and RNA was shown to bind in stoichiometric ratios, which suggests that there are two RNA binding sites per FMRP molecule. FMRP was able to bind to its own message with high affinity (dissociation constant = 5.7 nM) and interacted with approximately 4 percent of human fetal brain messages. The absence of the normal interaction of FMRP with a subset of RNA molecules might result in the pleiotropic phenotype associated with fragile X syndrome.
Dual processor automotive controller (2003)

A dual-processor controller has been developed for evaluating advanced automotive control algorithms. The controller is architectured around a general-purpose microcontroller and a digital signal processor. The main goal of the design is efficient computation of mathematically oriented algorithms with the ability to interface with sensors and actuators. The effectiveness of the system architecture was demonstrated by a real-time fast-Fourier-transform application to road characterization and by state estimation of a quarter car test rig. Also shown was the ability of such controllers to handle modern control theory requirements as applied to an optimal active suspension control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Liposomal lactoferrin induced significant increase of the interferon‐alpha (IFN‐α) producibility in healthy volunteers (2004)

Interferon-alpha (IFN-alpha) producibility has been widely accepted as one of the important markers to evaluate the immune status. In this study, preliminary clinical tests were carried out to confirm the immunomodulatory activity of liposomal lactoferrin including IFN-alpha producibility and NK activity. In a primary open trial, the liposomal lactoferrin was administered to five healthy males for one week and various immunological indices were evaluated. Furthermore, ten healthy males were administered 319 mg per day of liposomal or non-liposomal lactoferrin for four weeks, and immune status was monitored at 0, 1 and 4 weeks after the intake as well as three weeks after stopping it. In this double-blinded comparative study, the IFN-alpha producibility was significantly increased only in the liposomal lactoferrin group during administration and decreased 3 weeks after stopping it, while the IFN-alpha producibility was unchanged in the non-liposomal lactoferrin group. Although the biological mechanism of IFN-alpha producibility enforced by liposomal lactoferrin has not been wholly understood, it is suggested to be a novel active constituent having preventive and therapeutic effects on inflammatory diseases, cancer and infectious diseases such as chronic hepatitis C.