gebhart/patrepeval huggingface dataset:
A Multi-Buffer Scheduling Scheme for Video Streaming (2005)

In this paper, we propose a multi-buffer scheduling scheme for streaming video systems. A transmission rate is obtained via a rate control algorithm, which optimally utilizes the network bandwidth and client buffer resources. The server side maintains multiple buffers for packets of different importance levels. It schedules the transmission of each packet based on the source buffer size and playback deadline to reduce the end-to-end distortion. The performance of proposed scheme is evaluated in terms of peak signal-to-noise ratio (PSNR) in the simulations, and the simulation results demonstrate the improvement of the average PSNR values compared with two other scheduling schemes.
High-mannose-type oligosaccharides from human placental arylsulfatase A are core fucosylated as confirmed by MALDI MS (2000)

Despite numerous studies on arylsulfatase A, the structure of its glycans is not well understood. It has been shown that the concentration of arylsulfatase A increases in the body fluids of patients with some forms of cancer, and the carbohydrate component of arylsulfatase A synthesized in tumor tissues and transformed cells undergoes increased sialylation, phosphorylation and sulfation. To understand the significance of any changes in the glycosylation of arylsulfatase A in cancer, it is important to know the structure of its carbohydrate component in normal tissue. In the present study we have analyzed carbohydrate moieties of human placental arylsylfatase A using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) followed by Western blotting on Immobilon P and on-blot deglycosylation using PNGase F for glycan release. Profiles of N-glycans were obtained by matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). Oligosaccharides were sequenced using specific exoglycosidases, and digestion products were analyzed by MALDI MS and the computer matching of the resulting masses with those derived from a sequence database. Fifty picomoles (6 microg) of arylsulfatase A applied to the gel were sufficient to characterize its oligosaccharide content. The results indicated that human placental arylsulfatase A possesses only high-mannose-type oligosaccharides, of which almost half are core fucosylated. In addition, there was a minor species of high-mannose-type glycan bearing six mannose residues with a core fucose. This structure was not expected since high-mannose-type oligosaccharides basically have not been recognized as a substrate for the alpha1,6-fucosyltransferase.
The Role of IL‐6 Type Cytokines and Their Receptors in Bonea<sup>a</sup> (1998)

Substantial evidence indicates that the IL-6 type of cytokines have profound effects on bone metabolism by regulating osteoclast and osteoblast development and function. In addition, there is evidence that the gp130 signal transduction pathway may be a critical site for the regulation of the rate of bone remodeling, and probably the coupling of bone resorption to bone formation. Sex steroids inhibit the expression of the genes encoding IL-6, gp80, and gp130, most likely by repressing the activity of transcription factors such as NF kappa B and NF-IL-6. Considering this and the evidence that IL-6 autoregulates its own production and can upregulate the components of its receptor, removal of the direct inhibitory effects of sex steroids on IL-6, gp80, and gp130 could unleash a self-amplifying cascade of events responsible for increasing not only the production of IL-6, but also the responsiveness of osteoclast progenitors, osteoblast progenitors, and stromal/osteoblastic cells that support osteoclastogenesis, or combinations of these cells, to IL-6 type cytokines. Such a scenario could explain both the increased osteoclastogenesis and osteoblastogenesis that follows loss of gonadal function and thereby the effect of such loss on the rate of bone remodeling and skeletal homeostasis. Manipulation of the effects of IL-6 type cytokines, by selectively targeting to specific bone cell precursors, may allow means of altering the balance between bone resorption and formation in favor of the latter.
In vitro expression of a 38,000 dalton heparin‐binding glycoprotein by morphologically differentiated smooth muscle cells (1986)

In vitro, high density monolayer cultures of vascular smooth muscle cells can be induced to form multicellular nodules. The nodular cells appear to be morphologically differentiated smooth muscle cells. Sodium dodecyl sulfate (NaDodSO4)-polyacrylamide gel electrophoresis was used to compare the proteins synthesized and secreted by monolayer and nodular cultures of smooth muscle cells. Although most proteins appeared to be similar, the nodular cultures contained a unique heparin binding protein of Mr = 38,000 (38kD protein) (Millis, A.J.T., Hoyle, M., Reich, E., and Mann, D.M., 1985, J. Biol. Chem., 260:3754-3761). The 38kD protein was glycosylated and its apparent molecular weight was shifted to Mr = 32,500 after synthesis in the presence of tunicamycin or digestion with endoglycosidase F. The production of 38kD protein by nodular cell cultures did not appear to result from the degradation of a high molecular weight precursor in nodular conditioned medium. Further, it was not detected in monolayer cell conditioned medium that had been incubated with nodular cells. Finally, its synthesis was not induced in monolayer cell cultures that had been labeled in nodular cell conditioned medium. The 38kD protein appears to be uniquely associated with nodular cultures of smooth muscle cells.
Mitochondrial functions on oocytes and preimplantation embryos (2009)

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization (IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays a vital role in the oocyte cytoplasm, for it can provide adenosine triphosphate (ATP) for fertilization and preimplantation embryo development and also act as stores of intracellular calcium and proapoptotic factors. During the oocyte maturation, mitochondria are characterized by distinct changes of their distribution pattern from being homogeneous to heterogeneous, which is correlated with the cumulus apoptosis. Oocyte quality decreases with the increasing maternal age. Recent studies have shown that low quality oocytes have some age-related dysfunctions, which include the decrease in mitochondrial membrane potential, increase of mitochondrial DNA (mtDNA) damages, chromosomal aneuploidies, the incidence of apoptosis, and changes in mitochondrial gene expression. All these dysfunctions may cause a high level of developmental retardation and arrest of preimplantation embryos. It has been suggested that these mitochondrial changes may arise from excessive reactive oxygen species (ROS) that is closely associated with the oxidative energy production or calcium overload, which may trigger permeability transition pore opening and subsequent apoptosis. Therefore, mitochondria can be seen as signs for oocyte quality evaluation, and it is possible that the oocyte quality can be improved by enhancing the physical function of mitochondria. Here we reviewed recent advances in mitochondrial functions on oocytes.
Evolving predictors for chaotic time series (1998)

Neural networks are a popular representation for inducing single-step predictors for chaotic times series. For complex time series it is often the case that a large number of hidden units must be used to reliably acquire appropriate predictors. This paper describes an evolutionary method that evolves a class of dynamic systems with a form similar to neural networks but requiring fewer computational units. Results for experiments on two popular chaotic times series are described and the current method's performance is shown to compare favorably with using larger neural networks.
Mechanisms of Human Papillomavirus-Induced Oncogenesis (2004)

Papillomaviruses are small nonenveloped viruses with 55-nm-diameter icosahedral capsids that contain double-stranded DNA genomes of approximately 8,000 bp. They are widely distributed throughout the animal kingdom, specifically infect squamous epithelia, and cause the generation of warts. An
Pretreatment for surface leakage current reduction in type-II superlattice MWIR photodetectors (2014)

Focal plane array based on InAs/GaSb type-II superlattice (T2SL) is expected as an alternative to HgCdTe. To get more competitive performance of T2SL detector, we need building up more reliable fabrication process. Especially, mesa formation and passivation with understanding of surface leakage mechanism is critical issue. Generally, the existence of dangling bonds at crystal surface or damaged layer and native oxides on etched mesa sidewall leads to surface leakage currents, which mostly degrade the detector performance. Many researchers adopted SiO2 film as an effective passivation layer, which was deposited by plasma enhanced chemical vapor deposition at low temperature. However, good passivation requires not only stable film, but also an effective surface treatment before passivation. There are few reports, which discuss the relation between treatment before passivation and device characteristics in T2SL photodetectors. In this work, we present dry etching mesa formation and the effect of pretreatment of passivation on T2SL p-i-n photodetector fabrication. We investigate R0A-Perimeter/Area relation and R0A temperature dependence with in-situ plasma treatment prior to the passivation. From results of electrical characterization and interface analysis using STEM, it is recognized that in-situ N2 plasma treatment was effective to surface leakage reduction.
Targeted disruption of oncostatin M receptor results in altered hematopoiesis (2003)

Oncostatin M (OSM) is a multifunctional cytokine that belongs to the interleukin 6 (IL-6) family. As OSM is expressed in adult as well as embryonic hematopoietic tissues, OSM has been considered to play a role in hematopoiesis. To uncover roles of OSM, we have generated mutant mice deficient in the OSM-specific receptor beta subunit (OSMR). While OSMR-/- mice were healthy and fertile, hematologic analysis of OSMR-/- mice demonstrated that the numbers of peripheral erythrocytes and platelets were reduced compared with wild-type mice. Consistent with this, progenitors of erythroid and megakaryocyte lineages were reduced in OSMR-/- bone marrow (BM), suggesting that OSM is required for the maintenance of erythroid and megakaryocyte progenitor pools in BM. To investigate whether OSM acts on the hematopoietic progenitors directly or indirectly, we performed BM transplantation experiments. The OSMR-/- mice, engrafted with wild-type BM cells, failed to produce erythrocytic and megakaryocytic progenitors to the levels in wild-type mice, indicating that OSM affects hematopoietic microenvironments. On the other hand, erythrocytic and megakaryocytic progenitors were reduced in the wild-type mice reconstituted with OSMR-/- BM cells. Thus, OSM regulates hematopoiesis in vivo by stimulating stromal cells as well as hematopoietic progenitors, in particular megakaryocytic and erythrocytic progenitors.
Linearization of Optical Channels with Stokes Vector Direct Detection (2015)

Aiming to improve the performance of short-reach optical communications, Stokes-vector direct detection (SV-DD) is proposed to realize linear complex optical channels. In this paper, we present the principle and discuss the performance of SV-DD modulation format.
Dithienosilole− and Dibenzosilole−Thiophene Copolymers as Semiconductors for Organic Thin-Film Transistors (2006)

The synthesis and physicochemical properties of a new class of thiophene/arenesilole-containing pi-conjugated polymers are reported. Examples of this new polymer class include the following: poly(2,5-bis(3',3' '-dihexylsilylene-2',2' '-bithieno)thiophene) (TS6T1), poly(2,5'-bis(3' ',3' ''-dihexylsilylene-2' ',2' ''-bithieno)bithiophene) (TS6T2), poly(2,5'-bis(2' ',2' ''-dioctylsilylene-1' ',1' ''-biphenyl)thiophene) (BS8T1), and poly(2,5'-bis(2' ',2' ''-dioctylsilylene-1' ',1' ''-biphenyl)bithiophene) (BS8T2). Organic field-effect transistors (OFETs) with hole carrier mobilities as high as 0.02-0.06 cm2/V s in air, low turn-on voltages, and current on/off ratios >105-106 are fabricated using solution processing techniques with the above polymers as the active channel layer. OFETs based on this polymer class exhibit excellent ambient operational stability.
Reliability-based computational model for material development and structural design (2001)

This paper discusses a methodology to aid in the design and to predict the reliability of metallic components using probabilistic microstructural fatigue models. The capabilities are aimed at predicting the variation in fatigue life based on the statistical variation of the microstructure of the material. Material parameters at metallic grain level are used along with fundamental physics-based models to predict the damage as it accumulates. The methods use a virtual prototyping technique relying on computer simulation of real material behaviour. The computer simulates many &quot;identical&quot; components, but uses a different sample of material microstructure for each simulation. The microstructure of each simulated component is properly sampled from the specified range of material parameters. Each of the components is then virtually tested using computer models to simulate real-world usage conditions. The virtual testing allows the &quot;gathering&quot; of data on thousands or even millions of components.
Wheat Loads and Vertical Pressure Distribution in a Full-scale bin Part II Detention (1996)

The vertical loads imposed on a full-scale bin floor by wheat were measured during a storage time of 6 h. The floor loads were determined to be dependent on the length of storage time. A linear regression model was developed to predict this change in loads in relation to detention time. The linear regression equation had coefficient of determination values ranging from 0.230 to 0.817. Analysis of the model slopes also indicated that fill height and radial location affect the vertical floor loads with a statistical significance level of 0.05.
Modulation of Protein-Protein Interactions by Stabilizing/Mimicking Protein Secondary Structure Elements (2006)

In view of the crucial role of protein-protein intercommunication both in biological and pathological processes, the search of modulators of protein-protein interactions (PPIs) is currently a challenging issue. The development of rational strategies to imitate key secondary structure elements of protein interfaces is complementary to other approaches based on the screening of synthetic or virtual libraries. In this sense, the present review provides representative examples of compounds that are able to disturb PPIs of therapeutic relevance, through the stabilization or the imitation of peptide hot-spots detected in contact areas of the interacting proteins. The review is divided into three sections, covering mimetics of the three main secondary structural elements found in proteins, in general, and in protein-protein interfaces, in particular (alpha-helices, beta-sheets, and reverse turns). Once the secondary element has been identified, the first approach typically involves the translation of the primary peptide structure into different cyclic analogues. This is normally followed by gradual decrease of the peptide nature through combination of peptide and non-peptide fragments in the same molecule. The final step usually consists in the development of pertinent organic scaffolds for appending key functional groups in the right spatial disposition, as a means towards totally non-peptide small molecule PPI modulators.
Use of shifted phase encoded joint transform correlation for class associative color pattern recognition (2006)

Color pattern recognition techniques involve the separation of basic color components, red, green and blue, by using color filters. Although several joint transform correlation architectures have been proposed in literature for color pattern recognition, however, these algorithms are suitable for single color target detection only and most of them are sensitive to noise and do not efficiently utilizes the space bandwidth product. A new shifted phase-encoded fringe-adjusted joint transform correlation (SPJTC) technique has been proposed in this paper for class-associative color pattern recognition. The color images are first split into three fundamental color components and the individual components are then processed simultaneously through three different channels. The SPJTC technique for each color component again involves two channels, one with the reference image and the other with 180° phase-shifted reference image. Both are phase masked using a random phase and then used with the input scene. The joint power spectra (JPS) are again phase masked and subtracted one from the other. The resultant JPS yields the desired correlation after inverse Fourier transformation. A modified class-associative color fringe adjusted filter is developed for providing single and sharp correlation peak per target while satisfying the equal correlation peak criterion for each class member. The salient feature of the proposed scheme is that the number of channels and processing steps remains constant irrespective of the number of members in the class. Computer simulation verifies the effectiveness of the proposed technique for color images both in binary and gray levels even in presence of noise.
On the radiation patterns of parasitic loop counterpoise antennas (1970)

The radiation properties of parasitic loop counterpoise antennas are investigated in detail. It is found that the parasitic loop concept can be used advantageously to reduce considerably the undesirable effects produced in loop counterpoise antenna patterns due to the counterpoise edge diffraction effects. Results of extensive numerical and experimental investigation of various aspects of the parasitic loop counterpoise antenna patterns are reported. The method of design of such antennas is also discussed. Three such new antennas are proposed which appear to be capable of bringing out superior performance from the present-day VOR system.
A MEMS-based flexible multichannel ECoG-electrode array (2009)

We present a micromachined 252-channel ECoG (electrocorticogram)-electrode array, which is made of a thin polyimide foil substrate enclosing sputtered platinum electrode sites and conductor paths. The array subtends an area of approximately 35 mm by 60 mm and is designed to cover large parts of a hemisphere of a macaque monkey's cortex. Eight omnetics connectors are directly soldered to the foil. This leads to a compact assembly size which enables a chronic implantation of the array and allows free movements of the animal between the recording sessions. The electrode sites are 1 mm in diameter and were characterized by electrochemical impedance spectroscopy. At 1 kHz, the electrode impedances vary between 1.5 kOmega and 5 kOmega. The yield of functioning electrodes in three assembled devices is 99.5%. After implantation of a device with 100% working electrodes, standard electrocorticographic signals can be obtained from every electrode. The response to visual stimuli can be measured with electrodes lying on the visual cortex. After an implantation time of 4.5 months, all electrodes are still working and no decline in signal quality could be observed.
Application of the polymerase chain reaction to the ribonuclease protection assay. (1992)

We have developed a modified RNase protection assay in which the antisense RNA probe is prepared from a PCR-amplified DNA template rather than from a linearized plasmid DNA template. In this assay, an RNA polymerase promoter sequence is attached to the 5' end of the antisense PCR primer. Using this modified antisense primer in conjunction with the paired sense primer, PCR amplification generates a linear DNA template that includes an RNA polymerase promoter sequence. Transcription in vitro initiated by the incorporated promoter in the presence of RNA polymerase and ribonucleotide triphosphates produces a radiolabeled run-off antisense RNA transcript, which can then be used as probe for RNase protection analysis. Probes generated by this method obviate the need to subclone DNA sequences into transcription vectors for synthesis of antisense transcripts. Due to the simplicity of its design and the lack of need for subcloning, this strategy offers greater flexibility than conventional methods for the production of single-stranded RNA probes, and thus facilitates the implementation of the ribonuclease protection assay.
Do Not Say Ever Never More: The Ins and Outs of Antiangiogenic Therapies (2010)

Angiogenesis has been described as one of the hallmarks of cancer, playing an essential role in tumor growth, invasion, and metastasis. Antiangiogenic therapy was initially perceived as a "magic bullet" that could eventually be used for the treatment of any type of cancer. For this reason inhibition of angiogenesis has become a major challenge in the development of new anticancer agents, with a countless number of antiangiogenic strategies being tested in preclinical and clinical trials. The initial pessimism about the usefulness of the antiangiogenic therapeutic approach for cancer, derived from the poor results obtained in clinical trials, turned into euphoria after the approvals of the anti-VEGF monoclonal antibody bevacizumab and the multitargeted tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib. Nowadays the clinical development of antiangiogenic therapies seems to be unstoppable, not only for cancer, but also for an increasing number of non-neoplasic angiogenesis-related diseases. Nevertheless, careful analysis of the clinical results reveals that therapy with angiogenesis inhibitors often does not prolong survival of cancer patients for more than months. This fact, combined with the high prices of the new antiangiogenic therapies have made a number of oncologists to doubt if they offer "good value". Moreover, recent experimental findings suggest that some antiangiogenic drugs could promote tumor invasiveness and metastasis. The success in the discovery and pharmacological development of future generations of angiogenesis inhibitors will benefit from further advances in the understanding of the mechanisms involved in human angiogenesis.
Parallel synthetic aperture radar processing on workstation networks (2002)

Synthetic aperture radar (SAR) signal processing poses a significant challenge due to its very large computation and data storage requirements. This paper presents the computational requirements of a typical high resolution satellite SAR data processing scenario. A classification of approaches to partitioning the SAR problem for parallel processing is given. The suitability of networks of workstations (NOW) for SAR processing is analyzed for a number of partitioning approaches. The network throughputs required to support SAR processing on NOW are derived. SAR processing is found to demand extremely high network throughput that is difficult to achieve with today's technology.