gebhart/patrepeval huggingface dataset:
Expression of Neurotensin and NT1 Receptor in Human Breast Cancer: A Potential Role in Tumor Progression (2006)

Emerging evidence supports neurotensin as a trophic and antiapoptotic factor, mediating its control via the high-affinity neurotensin receptor (NT1 receptor) in several human solid tumors. In a series of 51 patients with invasive ductal breast cancers, 34% of all tumors were positive for neurotensin and 91% positive for NT1 receptor. We found a coexpression of neurotensin and NT1 receptor in a large proportion (30%) of ductal breast tumors, suggesting a contribution of the neurotensinergic signaling cascade within breast cancer progression. Functionally expressed NT1 receptor, in the highly malignant MDA-MB-231 human breast cancer cell line, coordinated a series of transforming functions, including cellular migration, invasion, induction of the matrix metalloproteinase (MMP)-9 transcripts, and MMP-9 gelatinase activity. Disruption of NT1 receptor signaling by silencing RNA or use of a specific NT1 receptor antagonist, SR48692, caused the reversion of these transforming functions and tumor growth of MDA-MB-231 cells xenografted in nude mice. Our findings support the contribution of neurotensin in human breast cancer progression and point out the utility to develop therapeutic molecules targeting neurotensin or NT1 receptor signaling cascade. These strategies would increase the range of therapeutic approaches and be beneficial for specific patients.
Atlas of Normal and Variant Angiographic Anatomy (1990)

An atlas depicting the normal and variant anatomy of the arteries, veins, and lymphatic system. Line drawings clarify the information on normal and common variations that the angiograms present, with each illustrations in the text labelled for easy identification. The book is intended to help vascular surgeons plan their operations and interpret angiographic studies. It covers the liver, spleen, pancreas, kidney, trunk, extremities, brain, adrenal glands and more.
Arginine Synthesis in Grapevine Leaves and Berries: Diurnal and Seasonal Patterns, Environmental and Physiological Influences (1995)

The diurnal and seasonal pattern of <i>de novo</i> arginine synthesis from <sup>14</sup>C-labeled bicarbonate in basal and apical leaf blades and berries of grapevines (<i>Vitis vinifera</i> L.) was investigated using an enzymatic assay procedure. The amount of NaH<sup>14</sup>CO<sub>3</sub> incorporated into arginine in leaves was low during the pre-bloom and post-harvest periods, rose to its highest level during the beginning and middle of the ripening period, and decreased to low levels at the end of the ripening period. Arginine synthesis in basal fully expanded leaves was greater than in young apical leaves. On a fresh weight basis, berries were not as active as leaves in arginine formation. In both leaves and berries, NaH<sup>14</sup>CO<sub>3</sub> incorporation into arginine was low at night and early morning, and maximal mid-day. Leaves well exposed to sunlight synthesized more arginine than shaded leaves during the mid-day period. Arginine formation in shaded leaves, leaves collected predawn, and berries collected predawn was increased by supplying glucose or NADPH. Arginine formation in leaf and berry tissue collected pre-dawn were significantly increased by exogenously supplied ornithine. These results suggest that both carbohydrate status and reductant supply influence the rate of arginine synthesis in grape berries by affecting the arginine pathway prior to the formation of ornithine.
Modular robots-graphical interactive programming (2003)

The ACRO project, a study of modular low-price precision robots, is presented. Every manipulator is constructed on demand from a group of standardized modules. Axis modules are actuated by stepping motors, allowing high precision and avoiding of expensive position encoders. An economical computer-based system robot controller with open multiprocessor structure is also described. The user interface, ROPSE, is an assistance module for both offline robot programming and robot guidance, using interactive graphics. Debugging tools include a teaching-by-showing module that provides an unconventional solution to driving stepping motors using digital open-loop control. Two different robots have been built from the standardized modules. Results demonstrate highly accurate positioning and low cost offered by this flexible control system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Optical gain and high quantum efficiency of matrix-free, closely packed CdSe quantum dots (1997)

Solid films of matrix-free, closely packed CdSe nanocrystals have been prepared and surface stabilized. An efficient suppression of nonradiative recombination channels is achieved. The absolute quantum efficiency has been determined spectrally resolved using an integrating sphere, and values between 1% and 10% are obtained in dependence on temperature. Spectrally broad optical gain has been found with the maximum around 510 nm.
“火卫--土壤”探测器怎么了？ (2012)

1月15日，2011年11月8日发射的俄罗斯“火卫一一土壤”星际探测器失控进入地球大气层。据俄罗斯航空航天国防军提供的信息，该事件于莫斯科时间20时45分（格林尼治时间17时45分）发生在太平洋智利惠灵顿岛以西1250公里洋面（约西经92度、南纬49度）上空。美国战略司令部称其于格林尼治时间17时46分（士1分钟）进入大气层，坐标位置在西经87度、南纬46度。偏差未超出预测精度——1分或沿轨道方向约500公里。
Noninvasive picoliter volume thermometry based on backscatter interferometry (2001)

Using the on-chip refractive index (RI) detector based on backscatter interferometry, sensitive, small volume, noninvasive thermometry can be performed. The current optical configuration for the on-chip interferometric backscatter detector (OCIBD) is quite simple and consists of an unfocused laser, an unaltered chip with a hemispherical channel and a photodetector. Alignment is straightforward with the only requirement being that the beam fully fills the channel. The interaction of an unfocused laser beam with the uncoated etched channel with a curvature within the silica plate (chip) produces fringes whose positional changes scale with respect to the refractive index (RI), n, of the fluid in the channel. Due to the inherently high value of dn/dT for most fluids and the high sensitivity of OCIBD to RI changes, the measurement of small temperature variations in sub-nanoliter volumes is possible. Performing OCIBD with a 75 microm diameter laser beam on a silica chip that contains an etched channel with a 40 microm radius facilitates noninvasive thermometry on a N-(2-hydroxyethyl)piperazine-(2-ethanesulfonic acid) (HEPES) solution in a 188 x 10(-12) L probe volume with a temperature resolution of 9.9 x 10(-4) degrees C, at the 99% confidence level.
Mutations and nuclear accumulation of β‐catenin correlate with intestinal phenotypic expression in human gastric cancer (2006)

Intestinal phenotypic expression is accompanied by a shift from membranous to cytoplasmic/nuclear accumulation of beta-catenin. In contrast, N-type regions may progress along a different pathway.
CHANGES IN BLOOD GLUCOSE AND LIPID PROFILE DURING (2000)

Background: It is an established fact that fasting influences carbohydrate and lipid metabolism resulting in changes in blood levels of glucose and lipid profile. This study describes the changes observed in the volunteers who fasted throughout the month of Ramadan. Methods: After screening, 24 volunteers were included in the study on the basis of their fasting blood glucose and cholesterol levels and different tests were conducted on serum. Results: Blood glucose, cholesterol, TAG and LDL-C levels decreased significantly, while HDL-C level rose considerably at the end of month. But the blood chemistry picture almost returned back to the pre-Ramadan level once fasting was discontinued for two weeks. Conclusion: It can therefore, be interpreted that the beneficial changes observed during the month of Ramadan are transient and could only be maintained if the dietary habits of Ramadan are continued afterwards.
Establishment of novel mAb to human ERC/mesothelin useful for study and diagnosis of ERC/mesothelin‐expressing cancers (2009)

Malignant mesothelioma is a highly aggressive tumor of the serosal cavity that arises from the mesothelial cells of the pleura, peritoneum, or pericardium. The immunohistochemical diagnosis of epithelioid mesothelioma from biopsy or surgically resected specimens has been actively pursued, using markers such as mesothelin. Several markers have indeed been helpful for confirming the diagnosis of mesothelioma and distinguishing between mesothelioma and adenocarcinoma. The authors have developed a novel mAb to human C-ERC/mesothelin, which performed well when used in western blotting, fluorescence-activated cell sorting, immunocytochemistry and immunohistochemistry, and which therefore will be useful in studying the molecular biology of mesothelin, in addition to improving the diagnosis and therapy of mesothelin-expressing cancers.
On the Design and Use of a Micro Air Vehicle to Track and Avoid Adversaries (2009)

The MAV ’08 competition focused on the problem of using air and ground vehicles to locate and rescue hostages being held in a remote building. To execute this mission, a number of technical challenges were addressed, including designing the micro air vehicle (MAV), using the MAV to geo-locate ground targets, and planning the motion of ground vehicles to reach the hostage location without detection. In this paper, we describe the complete system designed for the MAV ’08 competition, and present our solutions to three technical challenges that were addressed within this system. First, we summarize the design of our MAV, focusing on the navigation and sensing payload. Second, we describe the vision and state estimation algorithms used to track ground features, including stationary obstacles and moving adversaries, from a sequence of images collected by the MAV. Third, we describe the planning algorithm used to generate motion plans for the ground vehicles to approach the hostage building undetected by adversaries; these adversaries are tracked by the MAV from the air. We examine different variants of a search algorithm and describe their performance under different conditions. Finally, we provide results of our system’s performance during the mission execution.
Some Neglected Poultry Feedstuffs from Vegetable and Fruit Wastes (1982)

SummaryThe natural recycling of vegetable and fruit waste is an essential process for poultry nutrition.The increasing population of the world mostly in developing countries has to be compensated by food mainly from protein sources. If the waste of neglected industrial resources could be transferred into animal protein, in the form of eggs and meat, starvation and malnutrition among the people in some developing countries might be prevented.This study concerned the following residues:— 1. Tomato residues—tomato seed meal, dried tomato pomace and tomato seed cake. In general these products are characterised by an acceptable protein level but some limiting amino acids and high fibre content; maximum addition—5% level both for broilers and layers.2. Potato residue—is an effluent product, acceptable in protein level and high in total sugar content. It contains trypsin inhibitors and is very hygroscopic. Special care is necessary when using as a feedstuff—maximum 5% level.3. Citrus residues—citrus pulp and dried citrus sludge. Acceptable in NFE and protein, rich in colouring material but limited in some amino acids. They contain inhibiting factors such as limonin. Maximum level as feedstuff—10%.4. Date wastes—date waste without stones and with stones, acceptable for their nitrogen free extract, protein level and some essential amino acids. The only disadvantage is high fibre content. Maximum levels not yet established.
Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis (1998)

The generation of autoantibody and subsequent tissue deposition of immune complexes (IC) is thought to trigger the pathogenic consequences of systemic autoimmune disease. Modulation of the autoantibody response disrupts pathogenesis by preventing the formation of ICs; however, uncoupling IC formation from subsequent inflammatory responses seems unlikely because of the apparent complexity of the IC-triggered inflammatory cascade. However, the disruption of a single gene, which encodes the gamma chain of the Fc receptor, was found to achieve this uncoupling in a spontaneous model of lupus nephritis, the New Zealand Black/New Zealand White (NZB/NZW) mouse. Gamma chain-deficient NZB/NZW mice generated and deposited IC and activated complement, but were protected from severe nephritis, thus defining another potential pathway for therapeutic intervention in autoimmune disease.
One-dimensional parabolic-beam photonic crystal laser (2010)

We report one-dimensional (1-D) parabolic-beam photonic crystal (PhC) lasers in which the width of the PhC slab waveguide is parabolically tapered. A few high-Q resonant modes are confirmed in the vicinity of the tapered region where Gaussian-shaped photonic well is formed. These resonant modes originate from the dielectric PhC guided mode and overlap with the gain medium efficiently. It is also shown that the far-field radiation profile is closely associated with the symmetry of the structural perturbation.
Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents. (1982)

The specificity of substrates (including both phosphate donors and acceptors) for phospholipid-sensitive Ca2'-dependent protein kinase purified (80-95% homogeneous) from bovine heart and inhibition of its activity by various agents were investigated.The apparent K,,, for ATP, using histone H1 as substrate, of the enzyme was 4.4 p ~. Phosphorylation by ATP was inhibited most markedly by a,P-methylene ATP and, to a lesser extent, by adenosine 5'-0-(thiotriphosphate), 2'-deoxy ATP, and P,y-methylene ATP.The enzyme was able to utilize adenosine 5'-0-(thiotriphosphate) to thiophosphorylate histone H1.Among histone subfractions, peptides, and proteins examined, histone H1 (apparent K , = 0.6 PM; v , , = 0.83 pmol/min/mg of enzyme) and myelin basic protein (apparent K , = 0.3 PM;V , , = 0.83 pmol/min/mg of enzyme) were the best substrates for the enzyme.The enzyme partially purified from rat brain and pig spleen also effectively phosphorylated myelin basic protein, with apparent K , val-
Effectiveness of a reduced dose of efavirenz plus 2 NRTIs as maintenance antiretroviral therapy with the guidance of therapeutic drug monitoring (2014)

Switch to cART containing a half tablet of EFV (1/2#) in HIV-positive Taiwanese patients with higher plasma EFV concentrations who had achieved viral suppression could maintain successful viral suppression with the guidance of TDM.
Synthesis and properties of 4,4,9,9-tetramethyl[12]paracyclophane-5,6,7,8-tetrone (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and properties of 4,4,9,9-tetramethyl[12]paracyclophane-5,6,7,8-tetroneRolf Gleiter, Rolf Kraemer, Hermann Irngartinger, and Claus BissingerCite this: J. Org. Chem. 1992, 57, 1, 252–258Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jo00027a045https://doi.org/10.1021/jo00027a045research-articleACS PublicationsRequest reuse permissionsArticle Views300Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Calcaneal lengthening for valgus deformity of the hindfoot. Results in children who had severe, symptomatic flatfoot and skewfoot. (1995)

Thirty-one severe, symptomatic valgus deformities of the hindfoot in twenty children who had flatfoot (twenty-five feet) or skewfoot (six feet) were corrected with a modification of the calcaneal lengthening osteotomy described by Evans. Despite prolonged non-operative treatment, all patients had pain, a callus, ulceration, or a combination of these signs and symptoms under the head of the plantar flexed talus; they could not tolerate a brace, and shoe wear was excessive. Twenty-six of the deformities were secondary to an underlying neuromuscular disorder. The calcaneal lengthening was combined with an opening-wedge osteotomy of the medial cuneiform to correct the deformities of both the hindfoot and the forefoot in the patients who had a skewfoot. Other concurrent osseous and soft-tissue procedures were frequently performed in the flatfeet and skewfeet to correct adjacent deformities or to balance the muscle forces. Allograft bone was used in twenty-four feet and autogenous bone, in seven. The patients ranged in age from four years and seven months to sixteen years at the time of the operation. The duration of follow-up ranged from two years to three years and seven months after the operation. Satisfactory clinical and radiographic correction of all components of the deformity of the hindfoot was achieved in all but the two most severely deformed feet. These two feet had sufficient correction to eliminate the symptoms despite a small persistent callus under the head of the talus. The pain and callus were eliminated in all of the other feet, the patients were able to tolerate a brace, and shoe wear was improved. Subtalar motion was preserved in all feet except for the four that had had a limited joint arthrodesis performed previously or simultaneously for pre-existing degenerative osteoarthrosis. Calcaneal lengthening is effective for the correction of severe, intractably symptomatic valgus deformities of the hindfoot in children. My patients had resolution of the signs and symptoms associated with the deformity while avoiding the need for an arthrodesis and the many short and long-term complications associated with it.
A Fluoroimmunoassay Based on Immunoliposomes Containing Genetically Engineered Lipid-Tagged Antibody (1997)

Immunoliposomes were prepared by using biosynthetically lipid-tagged anti-2-phenyloxazolone single-chain antibody. Carboxyfluorescein as a fluorescent marker was encapsulated in the immunoliposomes. Some conditions for fluoroimmunoassay using the immunoliposomes were optimized by binding assays with hapten-coated microtiter wells. A competitive fluoroimmunoassay for the caproic acid conjugate of 2-phenyloxazolone as a model antigen was performed with the immunoliposomes. In the optimized assay conditions, antigen could be determined in the concentration range from 10(-7) to 10(-9) M.
Synthesis and Characterization of Bis(2,2‘:6‘,2‘ ‘-terpyridine)ruthenium(II)-Connected Diblock Polymers via RAFT Polymerization (2005)

We report the synthesis and uses of a novel terpyridine-functionalized chain transfer agent (CTA) that produces well-controlled macromolecular architectures with terpyridine functionalities at one chain end via reversible addition−fragmentation chain transfer (RAFT) polymerization. The terpyridine-terminated macromolecules with well-defined structures were further used for preparation of supramolecular diblock metallomacromolecules by bis(2,2‘:6‘,2‘ ‘-terpyridine)ruthenium(II) complex connectivity. The successful connectivity between two macromolecular blocks via the metallocomplex was confirmed by UV−vis, size exclusion chromatography (SEC), and differential scanning calorimetry (DSC) as well as atomic force microscopy (AFM) techniques.
A frequency–duty cycle equation for the ACGIH hand activity level (2014)

A new equation for predicting the hand activity level (HAL) used in the American Conference for Government Industrial Hygienists threshold limit value®(TLV®) was based on exertion frequency (F) and percentage duty cycle (D). The TLV® includes a table for estimating HAL from F and D originating from data in Latko et al. (Latko WA, Armstrong TJ, Foulke JA, Herrin GD, Rabourn RA, Ulin SS, Development and evaluation of an observational method for assessing repetition in hand tasks. American Industrial Hygiene Association Journal, 58(4):278-285, 1997) and post hoc adjustments that include extrapolations outside of the data range. Multimedia video task analysis determined D for two additional jobs from Latko's study not in the original data-set, and a new nonlinear regression equation was developed to better fit the data and create a more accurate table. The equation, HAL = 6:56 ln D[F(1:31) /1+3:18 F(1:31), generally matches the TLV® HAL lookup table, and is a substantial improvement over the linear model, particularly for F>1.25 Hz and D>60% jobs. The equation more closely fits the data and applies the TLV® using a continuous function.
Neutral Stream Extraction from Electron Cyclotron Resonance Plasma by Using Parallel Magnetic Field (1995)

A low-energy neutral stream is generated by charge exchange reactions between the accelerated ions in an electron cyclotron resonance plasma stream and the background molecules and atoms. This stream is extracted using a parallel magnetic field to eliminate charged particles. Etched Si profiles demonstrate that this neutral stream has high directionality.
Protein Digestion: An Overview of the Available Techniques and Recent Developments (2013)

Several proteomics approaches are available that are defined by the level (protein or peptide) at which analysis takes place. The most widely applied method still is bottom-up proteomics where the protein is digested into peptides that can be efficiently analyzed with a wide range of LC-MS or MALDI-TOF-MS instruments. Sample preparation for bottom-up proteomics experiments requires several treatment steps in order to get from the protein to the peptide level and can be very laborious. The most crucial step in such approaches is the protein digestion, which is often the bottleneck in terms of time consumption. Therefore, a significant gain in throughput may be obtained by speeding up the digestion process. Current techniques allow for reduction of the digestion time from overnight (~15 h) to minutes or even seconds. This advancement also makes integration into online systems feasible, thereby reducing the number of tedious sample handling steps and the risk of sample loss. In this review, an overview is given of the currently available digestion strategies and recent developments in the acceleration of the digestion process. Additionally, tailored approaches for classes of proteins that pose specific challenges are discussed.