gebhart/patrepeval huggingface dataset:
Far Lateral Lumbar Disc Herniation Treated with an Anterolateral Retroperitoneal Approach (1992)

STURM, PETER F. MD*; ARMSTRONG, GORDON W. D. MD*; O'NEIL, D JOSEPH MD*; BELANGER, J M E GARRY MD† Author Information
Interaction of Diphtheria Toxin T Domain with Molten Globule-Like Proteins and Its Implications for Translocation (1999)

The transmembrane (T) domain of diphtheria toxin has a critical role in the low pH-induced translocation of the catalytic domain (A chain) of the toxin across membranes. Here it is shown that at low pH, addition of proteins in a partly unfolded, molten globule-like conformation converted the T domain from a shallow membrane-inserted form to its transmembrane form. Fluorescence energy transfer demonstrated that molten globule-like proteins bound to the T domain. Thus, the T domain recognizes proteins that are partly unfolded and may function in translocation of the A chain as a transmembrane chaperone.
NOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and -9 (2012)

This study identifies NOV as a new actor against inflammatory pain through regulation of MMPs thus uncovering NOV as an attractive candidate for therapeutic improvement in pain relief.
Generation of cytotoxic T lymphocytes specific for the prostate and breast tissue antigen TARP (2004)

Our findings suggest that synthetic TARP peptides, such as TARP(P5L)(4-13), may play a role in prostate and breast cancer immunotherapy.
SCALE: A tool for Simple Connectivity Assessment in Lossy Environments (2003)

Abstract — Wireless sensor networks will allow finegrained monitoring in a wide range of environment (indoor and outdoor). Many of these environments, present very harsh conditions for wireless communication using lowpower radios, including multipath/fading effects, reflections from obstacles, and attenuation from foliage. In this paper, we introduce SCALE, a network wireless measurement tool that uses packet delivery as the basic application-level metric. SCALE facilitates the gathering of packet delivery statistics using the same hardware platform and in the same environment targeted for deployment. Using up to 55 nodes, we were able to measure and study the connectivity conditions of two hardware platforms, Mica 1 and 2 motes, in three different environments: an outdoor habitat reserve, an urban outdoor environment in a university campus, and an office building, under systematically varied conditions. Among other things, we found that there is no clear correlation between packet delivery and distance in an area of more than 50 % of the communication range, temporal variations of packet delivery are correlated with mean reception rate of each link, and the percentage of asymmetric links varies from 5 % to 30%. Data collected using SCALE have interesting implications in the design, evaluation, and parameter tuning of sensor network protocols and algorithms. I.
A search for arteriovenous anastomoses in human skin using ultrasound Doppler (1993)

The possible existence of arteriovenous anastomoses (AVAs) in skin regions of the head and thorax has been investigated using the synchronous vasomotion of the AVAs. Simultaneous pairs of blood velocity recordings were made using pulsed, bidirectional Doppler ultrasound. In each pair of registrations, blood velocity was recorded in a reference artery supplying a skin area known to contain AVAs (the radial artery) together with one of four other arteries investigated, i.e. the facial artery, the angular artery, the temporal artery, and the cutaneous branches of the lateral thoracic artery. The typical large, regular fluctuations in blood velocities caused by synchronous vasomotion in the AVAs in the skin of the hand and fingers were observed invariably in the radial artery. Similar flow variations were found in the angular artery. The fluctuations in this and the radial artery were, in turn, found to be synchronous. However, we have not been able to find the flow pattern characteristic of AVA vasomotion in the temporal artery or in the cutaneous branches of the lateral thoracic artery. These results show that the skin area of the nose supplied by the angular artery contains AVAs. These AVAs partly may explain the important role of face skin in temperature regulation. These results also support the earlier assumptions that there are no or very few AVAs in the skin areas supplied by the temporal artery and the cutaneous branches of the lateral thoracic artery.
An Expanded Evaluation of the Relationship of Four Alleles to the Level of Response to Alcohol and the Alcoholism Risk (2005)

This report strengthens the support for a relationship between the HTTLPR L and GABAAalpha6 Ser385 alleles to low alcohol LR and to alcoholism in a prospectively studied cohort evaluated for LR in young adulthood and before the onset of alcohol dependence.
Experimental investigation of superfocusing of plasmonic lens with chirped circular nanoslits (2010)

A plasmonic lens with metallic chirped circular nanoslits corrugated on Au film supported on quartz substrate for the purpose of superfocusing was put forth and fabricated by means of focused ion beam direct milling technique. Topography of the lens was imaged using an atomic force microscope. After that a near-field scanning optical microscope was employed for optical characterization of focusing performance of the lens. Our experimental results verify the focusing performance and further demonstrate that they are in agreement with the theoretical calculation results. Focusing performance is significantly improved in comparison to that of the non-chirped lens. The lenses are possible to be used for the applications of bioimaging, detection, and inspection in submicron scale resolution.
A Novel Affinity Support Material for the Separation of Immunoglobulin G from Human Plasma (2002)

2-Methacrylamidohistidine (MAH) as a pseudospecific ligand was synthesized from methacryl chloride and histidine. Spherical beads with an average size of 50–63 μm were obtained by the radical suspension polymerization of MAH and 2-hydroxyethyl methacrylate (HEMA) conducted in an aqueous dispersion medium. Owing to the reasonably rough character of the bead surface, P(HEMA-co-MAH) beads had a specific surface area of 17.6 m2·g–1. Synthesized MAH was characterized by NMR. P(HEMA-co-MAH) beads were characterized by swelling studies, FT-IR spectroscopy, scanning electron microscopy (SEM) and elemental analysis. P(HEMA-co-MAH) affinity beads with a swelling ratio of 65% were used in the separation of human immunoglobulin G (HIgG) from aqueous solutions and human plasma. The maximum HIgG adsorption on the P(HEMA-co-MAH) adsorbents was observed at pH 7.4 for phosphate and at pH 6.0 for morpholinoethanesulfonic acid buffers. The HIgG adsorption onto the PHEMA adsorbents was negligible. Higher adsorption values (up to 46.5 mg·g–1) were obtained when the P(HEMA-co-MAH) adsorbents were used in aqueous solutions. Much higher amounts of HIgG were adsorbed from human plasma (up to 73.8 mg·g–1). Adsorption capacities of other blood proteins were obtained as 3.2 mg·g–1 for fibrinogen and 4.6 mg·g–1 for albumin. The total protein adsorption was determined to be 82.2 mg·g–1. The pseudospecific affinity beads allowed one-step separation of HIgG from human plasma. HIgG molecules could be repeatedly adsorbed and desorbed with these adsorbents without noticeable loss in their HIgG adsorption capacity.
Spectrum of Externally Modulated Optical Signals (2004)

The optical power spectrum of a signal externally modulated using a Mach-Zehnder modulator is calculated analytically. Optical power spectra are calculated for binary signals for which the drive signal has either raised-cosine or Bessel-filtered pulse shape as well as for duobinary signals created by Bessel filtering. While the optical power spectrum is often approximated by the electrical power spectrum of the drive signal, this approximation usually underestimates the spectral spreading of the optical signal. Differences between the optical spectrum and the drive-signal electrical spectrum are most significant for drive signals having longer rise and fall times. Modulator chirp also broadens the optical spectrum. Chirp-induced spectral broadening is more significant for drive signals having longer rise and fall times.
HOT: the emergence of health oriented telecommunication applications. (1992)

America has benefited from decades of outstanding health services. However, the American health system now is in crisis--with runaway medical cost inflation, hospital closures, and unacceptably high and increasing numbers of uninsured people. Key solutions for bringing the health system into balance remain untapped in the potentials of health-oriented telecommunication, or HOT applications. HOT applications could rally the immense unused personal resources of the public for improving their own health, help upgrade the delivery and efficiency of healthcare and its administration, and improve public health's ability to deal with present and emerging system-level problems impacting health.
Pteridines. XXVI. Preparation and properties of some 3,4- and 5,6-dihydropteridines (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPteridines. XXVI. Preparation and properties of some 3,4- and 5,6-dihydropteridinesEdward C. Taylor, Malcolm J. Thompson, Katherine Perlman, Rudolf Mengel, and Wolfgang PfleidererCite this: J. Org. Chem. 1971, 36, 26, 4012–4025Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/jo00825a003https://doi.org/10.1021/jo00825a003research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Serum, Seminal Plasma, and Sperm Count Monitoring During Treatment of Idiopathic Gynecomastia With an Aromatase Inhibitor (2007)

We report on a case of idiopathic gynecomastia treated effectively with an aromatase inhibitor (anastrozole). Monitoring of the therapy included evaluation of hormonal parameters in serum and seminal plasma, along with sperm count assessment.
Functional Renal Insufficiency During Long-Term Therapy with Captopril and Enalapril in Severe Chronic Heart Failure (1987)

Renal function was evaluated in 104 patients with severe chronic heart failure whom we treated with captopril or enalapril. Seventy patients showed no change or an improvement in renal function (group A), and 34 patients developed functional renal insufficiency (group B). Before converting-enzyme inhibition, group B patients received higher doses of furosemide (p less than 0.02) and had lower central venous pressures (p less than 0.05) than group A patients. After 1 to 3 months of converting-enzyme inhibition, an excessive reduction in left ventricular filling pressure (to less than 15 mm Hg) or mean arterial pressure (to less than 60 mm Hg) was noted in 28 of 34 (82%) patients in group B but in only 22 of 70 patients in group A (31%) (p less than 0.001). At the end of the study, drug-induced azotemia resolved after a reduction in the dosage of diuretics, despite unaltered treatment with captopril and enalapril. Hence, the deterioration of renal function after converting-enzyme inhibition in heart failure is not a toxic or immunologic reaction to therapy but results from specific hemodynamic events that can be ameliorated by sodium repletion.
Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production. (1990)

Inhibitory factors towards IL-1 have been identified in the urine and in the supernatants of human monocyte cultures and have been shown to act as receptor antagonists. We have investigated whether a natural inhibitor purified from human urine (uIL-1ra) and a recombinant molecule expressed using the gene for an IL-1 antagonist isolated from monocytes (rIL-1ra) can alter responses to human rIL-1 alpha in organ cultures of fetal rat long bones and neonatal mouse calvariae. The two preparations probably contained similar or identical molecules, because an antibody to rIL-1ra reacted with uIL-1ra by Western blot analysis. uIL-1ra and rIL-1ra specifically blocked stimulation of bone resorption by rIL-1 in both culture systems, as well as the increase in PGE2 production in cultured calvariae. Resorptive effects of parathyroid hormone and TNF-alpha were not blocked. The uIL-1ra preparation had some intrinsic resorbing activity, but on gel chromatography this appeared in fractions that eluted earlier than uIL-1ra. Concentration ratios of rIL-1ra to rIL-1 as low as 10 could block the resorptive response of fetal rat long bones, whereas concentration ratios of 100 to 1000 were required to block IL-1 action on neonatal mouse calvariae. The inhibitory effects appeared to be competitive, because increasing concentrations of IL-1 overcame the block of bone resorption in both systems and the inhibition of PGE2 production in calvariae.
A neural network model, its properties and applications (1990)

In this study, we propose a neural network model which generalizes the Hopfield neural network model. Like the original model the proposed model has the convergence property. It can model application problems that can not be modeled using the original Hopfield neural network.
We then study two major applications of the proposed model: (1) Associative memories. Associative memories are of great use in many areas, such as pattern recognition, signal processing, and machine learning. In using the proposed neural network as associative memories, two important issues have to be addressed: (a) efficient and effective construction of neural associative memories, (b) the memory capacity of such associative memory. Our results show that the proposed neural network increases the memory capacity. We obtained a good upper bound on the capacity of such neural associative memory using the worst case analysis. Other issues of the neural associative memory, such as the parasite memory, nearest convergence are also studied. (2) Combinatorial optimization problems. We study the Traveling Salesman Problem using the proposed neural network model. The proposed neural network model allows many effective adaptive techniques to escape from local optimums (one important reason why many previous researches did not succeed using Hopfield neural network). The results are very encouraging. The new neural algorithm has performance comparable not only to other neural algorithms, but also to some of the best conventional heuristic algorithms, such as Lin & Kernighan algorithm. The new neural algorithm also scales better than the Lin & Kernighan algorithm.
Mutational analysis of the substrate binding pockets of the Rous sarcoma virus and human immunodeficiency virus-1 proteases (1994)

Mutations, designed by analysis of the crystal structures of Rous sarcoma virus (RSV) and human immunodeficiency virus type 1 (HIV-1) protease (PR), were introduced into the substrate binding pocket of RSV PR. The mutations substituted nonconserved residues of RSV PR, located within 10 A of the substrate, for those in structurally equivalent positions of HIV-1 PR. Changes in the activity of purified mutants were detected in vitro by following cleavage of synthetic peptides representing wild-type and modified RSV and HIV-1 gag and pol polyprotein cleavage sites. Substituting threonine for valine 104 (V104T), S107N, I44V, Q63M or deletion of residues 61-63 produced enzymes that were 2.5-7-fold more active than the wild type RSV PR. Substituting I42D, M73V, and A100L produced enzymes with lower activity, whereas a mutant that included both M73V and A100L was as active as wild type. Several substitutions altered the specificity for substrate. These include I42D and I44V, which contribute to the S2 and S2' subsites. These proteins exhibited HIV-1 PR specificity for P2- or P2'-modified peptide substrates but unchanged specificity with P4-, P3-, P1-, P1'-, and P3'-modified substrates. Changes in specificity in the S4 subsite were detected by deletion of residues 61-63. These results confirm the hypothesis that the subsites of the substrate binding pocket of the retroviral protease are capable of acting independently in the selection of substrate amino acids.
Microarray-Based Screening for Molecular Markers in Medulloblastoma Revealed <b> <i>STK15</i> </b> as Independent Predictor for Survival (2004)

Medulloblastoma, a primitive neuroectodermal tumor of the cerebellum, is one of the most common central nervous system malignancies of childhood. Despite aggressive multimodal therapy, including surgery, irradiation, and chemotherapy, 5-year survival rates have only approached 50-60%. To identify potential candidate genes that predict for overall survival (OS), we performed a gene expression profiling analysis in 35 newly diagnosed medulloblastoma neoplasms. Subsequently, the nine most promising candidate genes were analyzed by immunohistochemistry and fluorescence in situ hybridization on tumor tissue microarrays representing a series of 180 tumors. We found 54 genes in which expression levels predicted for unfavorable survival in medulloblastoma. In line with the gene expression profiling analysis, a positive staining for STK15 (P = 0.0006), stathmin 1 (P = 0.001), and cyclin D1 (P = 0.03) was associated with an unfavorable OS, whereas cyclin B1, DAXX, Ki-67, MYC, NRAS, and p53 showed no statistical significant effect. In comparison to clinically defined parameters such as gender, age, metastatic stage, extent of tumor resection, application of chemotherapy, and tumor grade, positive staining for STK15 was identified as an independent prognostic factor for OS (P = 0.026). Moreover, additional gene copy numbers of MYC (P = 0.003) and STK15 (P = 0.05) predicted for poor survival. The combination of gene expression profiling with tissue microarray experiments allowed the identification of a series of candidate genes that predicts for survival in medulloblastoma. Of the results highlighted by the various data analysis procedures, genes associated with cell proliferation (cyclin D1), transcription (MYC), and especially mitosis (stathmin 1, STK15) appear particularly intriguing with respect to medulloblastoma pathomechanism.
Use of Monoclonal Anti-mouse Immunoglobulin to Detect Mouse Antibodies (1981)

Rat monoclonal antibodies specific for mouse kappa light chains and mouse gamma heavy chains have been generated. These rat monoclonal antibodies have been biosynthetically labelled with 35S methionine. The free label was dialyzed from the medium and, without further purification, the medium containing the radioactive monoclonal antibody was used in a radioimmunoassay to screen the sera of the immunized animals and hybridomas for specific mouse antibodies of the IgG class.
Serum complement levels and severity of sepsis. (1994)

The activities (C3a, C4a, C5a) and concentrations (CH50, C3, C4, C5) of serum complement were measured to evaluate the involvement of complement in sepsis. We studied 27 patients with sepsis who were divided into the survivors (Group 1) and the nonsurvivors (Group 2). The levels of C3a, C4a, and C5a were all significantly higher in Group 2 than in Group 1 and closely reflected the severity of sepsis. Levels of C3 and C4 were significantly lower in Group 2 than in Group 1, presumably because these components were consumed as a result of activation of both the alternative and classical pathways. The levels of CH50 and C5 did not differ significantly between the two groups. These findings suggest that complement is closely involved in the exacerbation of the condition of septic patients, and that the measurement of complement activity is useful for evaluating the severity of sepsis.
Resource allocation scheme for QoS provisioning in microcellular networks carrying multimedia traffic (2001)

Abstract We propose a new resource allocation scheme based on the concept of resource reservation and resource renegotiation. The new scheme is aimed at improving performance with regard to new call blocking rate, handoff dropping rate, forced call termination rate, and average bandwidth use. We compare our scheme with other schemes. The performance is evaluated by using simulation. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Antimicrobial Properties and Toxicity of Anthraquinones by Microcalorimetric Bioassay (2006)

Abstract The growth thermogenic curves of Staphylococcus aureus and Tetrahymena thermophila affected by 1,8‐dihydroxyanthraquinone, emodin and rhein were determined quantitatively by microcalorimetry. The inhibitory effects of the three anthraquinones (AQ) on S . aureus revealed that the sequence of antimicrobial activity of those was rhein&gt;emodin&gt;1,8‐dihydroxyanthraquinone. The toxicity of the three AQ on T. thermophila indicated that all the tested AQ were toxic to the tested protozoa and the hydroxyl and carboxyl substituted at different position of anthraquinone ring resulted in the enhancement of toxicity.
Enhancing field emission from a carbon nanotube array by lateral control of electrodynamic force field (2009)

Fluctuation of field emission current from carbon nanotubes (CNTs) poses certain difficulties for their use in nano-biomedical X-ray devices and imaging probes. This problem arises due to deformation of the CNTs due to electrodynamic force field and electron–phonon interaction. It is of great importance to have precise control of emitted electron beams very near the CNT tips. In this paper, a new array configuration with stacked array of CNTs is analysed and it is shown that the current density distribution is greatly localised at the middle of the array, that the scatter due to electrodynamic force field is minimised and that the temperature transients are much smaller compared to those in an array with random height distribution.
Darcy’s and Forchheimer’s laws in practice – Part 1: The experiment (2014)

b s t r a c t The aim of this study is to derive flow parameters, which are permeability and Forchheimer coefficient, based on experimentally measured flow rates and pressure drops. When flow rates used in measurements exceed the limits of linear Darcy’s flow regime we discuss what needs to be taken into account while processing the measurements. The study consists of two parts. In this part we briefly recall Darcy’s and Forchheimer’s laws and address the issue of detecting transition between ranges of their applicability. Then we describe the experiment and discuss 8 different ways to process measurement data, four for Darcy’s, and four for Forchheimer’s models. The main topic of the second part is to provide recommendations for the best ways to process data, so that the results obtained with numerical models are in the best agreement with the experimental data. The results shown in the two papers belong to a larger work devoted to modeling fluid flows through porous media, with a special interest in granular beds.