gebhart/patrepeval huggingface dataset:
M‐T2: A poxvirus TNF receptor homologue with dual activities (1996)

Poxviruses are experts at manipulating and evading the host's immune response. They have acquired a number of open reading frames which specifically confer direct anti-immune properties, either by mimicking cytokine receptors and growth factors or by disarming cytokine regulatory cascades. The Myxoma T2 protein (M-T2), a TNF receptor homologue, is secreted from virus infected cells and can bind TNF-alpha with high affinity, and thereby inhibit TNF-alpha-mediated cytotoxicity. M-T2 also acts to inhibit virus-induced lymphocyte apoptosis by an as yet undefined mechanism. As such, T2 constitutes a significant virulence factor for poxviruses, influencing the outcome of infection, both in vitro and in vivo.
Photoelectrochemical etching measurement of defect density in GaN grown by nanoheteroepitaxy (2006)

The density of dislocations in n-type GaN was measured by photoelectrochemical etching. A 10× reduction in dislocation density was observed compared to planar GaN grown at the same time. Cross-sectional transmission electron microscopy studies indicate that defect reduction is due to the mutual cancellation of dislocations with equal and opposite Burger’s vectors. The nanoheteroepitaxy sample exhibited significantly higher photoluminescence intensity and higher electron mobility than the planar reference sample.
FOOD INTAKE PRIOR TO A MIGRAINE ATTACK ‐STUDY OF 2,313 SPONTANEOUS ATTACKS (1975)

SYNOPSIS Sandler, Youdim and Hannington noted an inability to oxidise tyramine and phenylethylamene in dietary and non dietary migraine sufferers‐l,883 female volunteers in Britain completed questionnaires detailing food intake during the 24 hours prior to spontaneous migraine attacks. Analysis of 2,313 attacks are reported. This revealed consumption of chocolate in 33%, cheese 40%, citrus fruits 21% and alcohol 23%. Fasting (5 hours day or 13 hours overnight) occurred in 67%. No dietary factors were isolated in 5%. Only 14% thought food caused their attacks and 2% blamed fasting. Sensitising factors analysed included age, time in menstrual cycle, pill taking and hysterectomy. The findings suggest that in double blind trials designed to elucidate dietary factors, one needs to consider the patient's intake during the 24 hours prior to the administration of the test capsule. A new approach to treatment is suggested with elimination of specific foods and avoidance of fasting.
Evidence for an Ax‐adenosine receptor in the guinea‐pig atrium (1983)

1 The purpose of this study was to determine whether the adenosine receptor that mediates a decrease in the force of contraction of the guinea-pig atrium is of the A1- or A2-sub-type. 2 Concentration-response curves to adenosine and a number of 5'- and N6-substituted analogues were constructed and the order of potency of the purines was: 5'-N-cyclopropylcarboxamide adenosine (NCPCA) = 5'-N-ethylcarboxamide adenosine (NECA) greater than N6cyclohexyladenosine (CHA) greater than L-N6-phenylisopropyl adenosine (L-PIA) = 2-chloroadenosine- greater than adenosine greater than D-N6-phenylisopropyl adenosine (D-PIA). 3 The difference in potency between the stereoisomers D- and L-PIA was over 100 fold. 4 The adenosine transport inhibitor, dipyridamole, potentiated submaximal responses to adenosine but had no significant effect on those evoked by the other purines. 5 Theophylline antagonized responses evoked by all purines, and with D-PIA revealed a positive inotropic effect that was abolished by atenolol. 6 The results indicate the existence of an adenosine A1-receptor in the guinea-pig atrium.
Low-Power Discrete Fourier Transform for OFDM: A Programmable Analog Approach (2010)

The modulation and demodulation blocks in an orthogonal frequency-division multiplexing (OFDM) system are typically implemented digitally using a fast Fourier transform circuit. We propose an analog implementation of an OFDM demodulator as a means for reducing power consumption. The proposed receiver implements the discrete Fourier transform (DFT) as a vector–matrix multiplier using floating-gate transistors on a field-programmable analog array (FPAA). The DFT coefficients can be tuned to counteract an inherent device mismatch by adjusting the amount of electrical charge stored in the floating-gate transistors. When compared to a digital field-programmable gate array implementation, the analog FPAA implementation of the DFT reduces power consumption at the cost of a slight performance degradation. Considering the errors in the DFT coefficients as intersymbol interference, the performance degradation can be further mitigated by employing a least mean-square or minimum mean-square-error equalizer.
T-cell independent reconstitution of the immunoglobulin levels in nu/nu mice. (1982)

Nude mice (BALB/c, H-2d) were transplanted under the renal capsule either with allogeneic (CBA, H-2k; C57B1/6, H-2b) or human thymus that were long-term precultured or pretreated in vitro with Carrageenan for three days. None of the thymus tissue transplants showed lymphatic repopulation 9 wk after transplantation. Histological investigation of the peripheral lymphatic tissue did not reveal any change in the thymus-dependent area. On the other hand, plasma cells and germinal centers could be found in significantly increased numbers. In addition, a normalization of the serum immunoglobulin concentrations could be found, as no specific antibodies against thymus-dependent antigens were present after immunization and T-cell function did not improve. Similar results were obtained 9 wk after injection of irradiated thymocyte suspensions or of peritoneal macrophages from immunocompetent donors. It is concluded that thymus epithelial cells could act via macrophages on the polyclonal maturation and differentiation of B cells without involvement of T cells. This would be in agreement with the experience in some patients with severe combined immunodeficiency (SCID) in which reconstitution of the immunoglobulin levels is observed after transplantation of cultured thymus tissue before T-cell reconstitution can be demonstrated.
Chiral topological superconductor from the quantum Hall state (2010)

The chiral topological superconductor in two dimensions has a full pairing gap in the bulk and a single chiral Majorana state at the edge. The vortex of the chiral superconducting state carries a Majorana zero mode which is responsible for the non-Abelian statistics of the vortices. Despite intensive searches, this superconducting state has not yet been identified in nature. In this paper, we consider a quantum Hall or a quantum anomalous Hall state near the plateau transition and in proximity to a fully gapped $s$-wave superconductor. We show that this hybrid system may realize the chiral topological superconductor state and propose several experimental methods for its observation.
Hybrid Deep Learning for Face Verification (2013)

This paper proposes a hybrid convolutional network (ConvNet)-Restricted Boltzmann Machine (RBM) model for face verification in wild conditions. A key contribution of this work is to directly learn relational visual features, which indicate identity similarities, from raw pixels of face pairs with a hybrid deep network. The deep ConvNets in our model mimic the primary visual cortex to jointly extract local relational visual features from two face images compared with the learned filter pairs. These relational features are further processed through multiple layers to extract high-level and global features. Multiple groups of ConvNets are constructed in order to achieve robustness and characterize face similarities from different aspects. The top-layer RBM performs inference from complementary high-level features extracted from different ConvNet groups with a two-level average pooling hierarchy. The entire hybrid deep network is jointly fine-tuned to optimize for the task of face verification. Our model achieves competitive face verification performance on the LFW dataset.
Transcriptional regulation of CFTR gene expression (2011)

Cystic Fibrosis results from mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The gene was identified in 1989, but more than 20 years later, the regulatory mechanisms controlling its complex expression are still not fully understood. Though the promoter binds transcription factors and drives some aspects of CFTR gene expression, it cannot alone account for tissue specific control. This implicates other distal cis-acting elements in cell-type-specific regulation of CFTR expression. Several of these elements, including intronic enhancers and flanking insulators, were identified within or near the CFTR locus. Here we summarize the known regulatory mechanisms controlling CFTR transcription, including those acting through elements in the promoter and others elsewhere in the locus. A special focus will be elements that contribute to tissue specific regulation of expression.
Coulomb screening in low-energy nuclear reactions (1992)

Coulomb screening effects are studied in very-low-energy nuclear reactions. The two-potential formalism is shown to be a convenient method for the separation of long-range (molecular) and short-range (nuclear) dynamics. As specific applications, electron screening effects and muon catalysis in nuclear reactions are investigated. In the case of electron screening in very-low-energy nuclear reactions a method is elaborated for calculation of the enhancement of the astrophysical factor. For muon-catalyzed fusion reactions the sudden approximation is shown to be valid even if the reaction is dominated by a long-lived nuclear resonance.
Cardiac myosin-binding protein C: A protein once at loose ends finds its regulatory groove (2016)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Performance evaluation of panoramic electro-optic imagers using the TOD method (2011)

The triangle orientation discrimination (TOD) method is an emerging technique for the evaluation of electro-optical (EO) systems. In this method, the test pattern is a non-periodic equilateral triangle in one of four different orientations (apex up, down, left, or right), and the measurement procedure is a robust four-alternative forced-choice psychophysical process. This leads to a time-consuming task. Consequently, software models have been developed to replace the required human observers. These models base their decision on the orientation of the target using correlation between observed data and the set of four differently oriented targets. This study investigates for the first time how this method can be applied to highly distorted OE systems like hemispheric imagers. These types of systems have inherent large distortion, but the distortion should not be considered as an aberration but rather the result of the projection of a hemispheric field (3D) on a 2D sensor. The distortion deforms the image of the targets and image processing is usually performed to remove distortion and straighten the field of view. We present a comparison in accuracy and computational burden for the evaluation of EO system performance between cases where tested images are pre-processed and correlated to unchanged triangle targets and where untouched (distorted) images are correlated with position-wise distorted targets. This is a first evaluation of the application of the TOD with the goal of obtaining an image quality criterion for panoramic imagers.
On Successive Refinement for the Wyner–Ziv Problem (2004)

Achievable rates are characterized for successive refinement (SR) in the Wyner-Ziv scenario, namely, in the presence of correlated side information (SI) at the receivers. In this setting, the encoder is assumed to operate in two stages, where the first corresponds to relatively low rate and high distortion, and the second, comprising a refinement code on top of the first code, is aimed at reproduction at reduced distortion. Both decoders (for low rate/high distortion and for high rate/low distortion) are equipped with SI streams, correlated to the source, but unavailable to the encoder. Furthermore, it is assumed that the decoder that receives the higher rate bitstream, i.e., the additional refinement bits, accesses also SI of "better quality" than that of the lower resolution decoder. By "better quality," we mean that the source and the SI are modeled together as a stochastically degraded joint source, where the encoded symbols, the SI at the refinement stage, and the SI at the initial (coarse) stage, form a Markov chain in this order. For a memoryless joint process (that includes the source to be encoded and its instantaneously correlated SI streams), necessary and sufficient conditions are furnished, in terms of single-letter formulas, for the achievability of a pair of rates, corresponding to two given distortion levels. Special attention is devoted to the degenerate, but important, case where the two SI streams, at the two decoders, are identical. For this case, conditions are provided for successive refinability in the sense of the existence of codes that asymptotically achieve the Wyner-Ziv rate-distortion function, simultaneously at both distortion levels. In this context, the doubly symmetric binary source (with the Hamming distortion measure) and the jointly Gaussian source (with the squared error distortion measure) are successively refinable in the Wyner-Ziv setting. It is demonstrated that a source that is not successively refinable in the ordinary sense (i.e., without SI) may become successively refinable in the presence of SI at the decoders.
Synthesis and properties of diacetylenic glutamate lipid monomer and polymer: thermochromic polydiacetylene free-standing films (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and properties of diacetylenic glutamate lipid monomer and polymer: thermochromic polydiacetylene free-standing filmsThauming Kuo and David F. O'BrienCite this: Macromolecules 1990, 23, 13, 3225–3230Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/ma00215a005https://doi.org/10.1021/ma00215a005research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The antimetastatic effect of IV-inoculated BCG on adenocarcinomas in the prostate-seminal vesicle complex of L-W rats. (1994)

Adenocarcinomas were induced in the prostate-seminal vesicle complex of Lobund-Wister (L-W) rats by a single IV inoculation of N-methyl-N-nitrosourea. This was followed by three slow-release S.C. implants of testosterone propionate, each at intervals of 2 months. Small (0.5 cm diameter) palpable tumors developed which enlarged during the following month to 3-4 cm diameter. At the latter stage, tumor cells spread via lymphatics to the lungs and/or by direct extension into the peritoneal cavity. Rats with small palpable tumors were inoculated IV with viable Bacillus Calmette-Guerin (BCG). One month later, the rats were killed and examined. Untreated rats with large tumors served as controls. Comparison of the two groups revealed that body weights and tumor sizes were similar and most of them had developed metastatic tumors in the peritoneal cavity. However, lung metastases were rare in the BCG-inoculated rats compared to controls. Spleen and liver weights were significantly heavier in the BCG-treated rats. It is speculated that an intra-vascular mechanism(s), engendered by BCG, immobilized the circulating tumor cells, but not those tumor cells that spread by direct extension from the primary tumor into the peritoneal cavity.
Axisymmetric adhesion tests of soft materials (1998)

We describe a general, linearized fracture mechanics analysis for studying the adhesive properties of elastic, low modulus materials. Several adhesion tests are described, but all involve an elastic material which is brought into contact with a rigid surface along an axis of radial symmetry. Relationships between the load, displacement, and radius of the circular contact area between the two materials are described. These relationships involve the elastic modulus of the compliant material, the energy release rate (or adhesion energy) and various parameters which characterize the geometry of interest. The ratio of the contact radius to the thickness of the elastic material is shown to be a particularly important parameter. After reviewing some general concepts relevant to the adhesion of soft polymeric materials, we describe the fracture mechanics analysis, and provide examples from our own work on the adhesion of elastomers, thermoreversible gels and pressure sensitive adhesives.
Clinical Dementia Rating: A Reliable and Valid Diagnostic and Staging Measure for Dementia of the Alzheimer Type (1997)

Global staging measures for dementia of the Alzheimer type (DAT) assess the influence of cognitive loss on the ability to conduct everyday activities and represent the "ultimate test" of efficacy for antidementia drug trials. They provide information about clinically meaningful function and behavior and are less affected by the "floor" and "ceiling" effects commonly associated with psychometric tests. The Washington University Clinical Dementia Rating (CDR) is a global scale developed to clinically denote the presence of DAT and stage its severity. The clinical protocol incorporates semistructured interviews with the patient and informant to obtain information necessary to rate the subject's cognitive performance in six domains: memory, orientation, judgment and problem solving, community affairs, home and hobbies, and personal care. The CDR has been standardized for multicenter use, including the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) and the Alzheimer's Disease Cooperative Study, and interrater reliability has been established. Criterion validity for both the global CDR and scores on individual domains has been demonstrated, and the CDR also has been validated neuropathologically, particularly for the presence or absence of dementia. Standardized training protocols are available. Although not well suited as a brief screening tool for population surveys of dementia because the protocol depends on sufficient time to conduct interviews, the CDR has become widely accepted in the clinical setting as a reliable and valid global assessment measure for DAT.
Depression of natural killer activity and mitogen responsiveness in mice treated with pristane. (1982)

In BALB/c mice, the injection of pristane resulted in a severe decrease in splenic T and B cell proliferative responses to mitogens and in a depression of natural killer (NK) activity. The effects of T and B cells, which persisted for at least 5 mo, were mediated by different mechanisms. T cell responsiveness to PHA dropped significantly below control levels 1 wk after the first of three monthly pristane injections, whereas B cell proliferation in response to LPS did not decrease until 4 wk after the first injection. The removal of plastic-adherent suppressor cells completely restored T cell proliferative capacity, but had no effect on B cells. NK activity against YAC-1 tumor targets was reduced 1 mo after the first pristane injection and remained depressed for at least 3 mo. This depression was not mediated by plastic-adherent suppressor cells. Spleen cell NK activity from pristane-treated mice could not be augmented by the interferon inducer Poly I:C to the same extent as that of control mice. This suggests an effect of pristane on either pre-NK cells or on cells that regulate NK activity.
Neurobiology of Learning and Memory (1984)

Circadian rhythmic expression of conditioned place avoidance (CPA) was produced in Syrian hamsters homozygous for the circadian short period mutation, tau. In constant dim red light neither the 20 h endogenous period, nor a 20 h place conditioning schedule eliminated the 24 h modulation of CPA behav- ior described previously for wild type (wt) hamsters and other species. Tau mutants exhibited a 20 h rhythm superimposed on the 24 h modulation. The 20 h component was removed selectively with lesions of the suprachiasmatic nucleus. Wt animals conditioned on a 20 h schedule did not produce a 20 h rhythm, but still expressed the 24 h modulation. The results show that the context entrainable oscillator (CEO) underlying memory for the timing of an unconditioned stimulus, retains a period of about 24 h regardless of clock gene background (tau mutation) and/or the conditioning schedule (24 vs 20 h). There- fore the CEO responsible for time memory is distinct from the biological clock controlling activity; the underlying circadian molecular mechanisms may differ from the ubiquitous transcription-translation feedback oscillator; and time memory itself is not classically conditioned.
Low‐light image analysis of transgenic organisms using bacterial luciferase as a marker (1994)

Methods for measurement of a novel light-emitting reporter gene system in bacteria, yeast, plant cells, plant tissues and intact plant organs are described. The principle underlying the assay procedures is the bacterial luciferase catalysed oxidation of reduced flavin mononucleotide (FMNH2) in the presence of the ten carbon aldehyde decanal, to yield FMN, decanoic acid, water and a photon of light at 490 nm which can be captured by X-ray film, a photomultiplier tube or, for in vivo measurements, an image-intensifier coupled to a video camera. This light measuring assay system is sensitive, easy to use, inexpensive, does not require radioactivity, and has been used successfully for rapid detection of bacterial transformants, the quantitative measurement of transient and stable gene expression in bacteria and yeast, and in vivo measurement of temporal and spatial gene expression throughout plant and animal development.