gebhart/patrepeval huggingface dataset:
A Flexible Growth Function for Empirical Use (1959)

Journal Article A Flexible Growth Function for Empirical Use Get access F. J. RICHARDS F. J. RICHARDS Research Institute of Plant Physiology, Imperial College of ScienceLondon, S.W.7 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Experimental Botany, Volume 10, Issue 2, June 1959, Pages 290–301, https://doi.org/10.1093/jxb/10.2.290 Published: 01 June 1959
Recombinant Human Endostatin Normalizes Tumor Vasculature and Enhances Radiation Response in Xenografted Human Nasopharyngeal Carcinoma Models (2012)

Endostar normalized tumor vasculature, which alleviated hypoxia and significantly sensitized the function of radiation in anti-tumor in human NPC. The results provide an important experimental basis for combining endostar with radiation therapy in human NPC.
Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin (2011)

The present study clearly demonstrates that CD69 plays an important role in the progression of lung injury induced by BLM.
IP switching over fast ATM cell transport (IPSOFACTO): IP multicast over wireless ATM (2002)

IPSOFACTO is an IP switching technique that directly maps IP flows to ATM VCs without any signalling. This paper extends IP multicast using IPSOFACTO over wireless ATM. A wireless ATM system consists of a fixed core network and a shared wireless access link for mobile terminals. Unlike point-to-point ATM links within the fixed/wired network, wireless ATM link uses a common VC space for all mobile terminals and the medium access (MAC) protocol supports shared multiple access on the downlink, but only point-to-point unicast access on the uplink. This paper describes how IP multicast can be natively supported on such WATM links using IPSOFACTO along with specific extensions to the Internet Group Management Protocol (IGMP). In addition, a cell-level error recovery scheme at the DLC (data link control) layer is described to enhance the packet-level throughput of the transport layer.
Lipid Composition of Purified Vesicular Stomatitis Viruses (1971)

Methods are described for the production of vesicular stomatitis (VS) virus of sufficient purity for reliable chemical analysis. VS virions released from infected cells were concentrated and purified at least 150-fold by sequential steps of precipitation with polyethylene glycol, column chromatography, rate zonal centrifugation, and equilibrium centrifugation. The Indiana serotype (VS(Ind) virus) propagated in L-cells was found to contain 3% ribonucleic acid, 64% protein, 13% carbohydrate, and 20% lipid; the molar ratio of cholesterol to phospholipid was 0.6 or greater. Thin-layer chromatography revealed no unusual neutral lipids or phospholipids and gas-liquid chromatography revealed no unusual fatty acids incorporated into VS virions. The antigenically distinct New Jersey serotype (VS(NJ) virus) grown in L-cells showed a similar lipid profile except that the proportion of neutral lipids was larger than in VS(Ind) virus also grown in L-cells. This differences was less pronounced when the lipid composition of VS(Ind) and VS(NJ) viruses grown in chick embryo cells was compared, but VS(NJ) virus grown in either cell type always contained larger amounts of neutral lipids other than cholesterol than did VS(Ind) virus. The lipid composition of both VS(Ind) and VS(NJ) viruses grown in L-cells or chick embryo cells more closely resembled that of plasma membrane than of whole cells. A consistent finding was the relatively large amounts of phosphatidylethanolamine and sphingomyelin and the relatively small amounts of phosphatidylcholine in both VS viruses compared with uninfected whole L-cells and chick embryo cells or their plasma membranes. The methods available for isolation of plasma membranes were inadequate for conclusive comparison of the lipids of VS virions with the lipids of the plasma membranes of their host cells. Nevertheless, the data obtained are consistent with two hypotheses: (i) the lipid composition of VS viruses primarily reflects their membrane site of maturation, and (ii) the newly synthesized viral proteins inserted into cell membranes influence the proportions of phospholipids and neutral lipids selected for incorporation into the viral membrane.
Fully-Convolutional Siamese Networks for Object Tracking (2016)

The problem of arbitrary object tracking has traditionally been tackled by learning a model of the object's appearance exclusively online, using as sole training data the video itself. Despite the success of these methods, their online-only approach inherently limits the richness of the model they can learn. Recently, several attempts have been made to exploit the expressive power of deep convolutional networks. However, when the object to track is not known beforehand, it is necessary to perform Stochastic Gradient Descent online to adapt the weights of the network, severely compromising the speed of the system. In this paper we equip a basic tracking algorithm with a novel fully-convolutional Siamese network trained end-to-end on the ILSVRC15 dataset for object detection in video. Our tracker operates at frame-rates beyond real-time and, despite its extreme simplicity, achieves state-of-the-art performance in multiple benchmarks.
Efficient implementation of sorting on multi-core SIMD CPU architecture (2008)

Sorting a list of input numbers is one of the most fundamental problems in the field of computer science in general and high-throughput database applications in particular. Although literature abounds with various flavors of sorting algorithms, different architectures call for customized implementations to achieve faster sorting times. This paper presents an efficient implementation and detailed analysis of MergeSort on current CPU architectures. Our SIMD implementation with 128-bit SSE is 3.3X faster than the scalar version. In addition, our algorithm performs an efficient multiway merge, and is not constrained by the memory bandwidth. Our multi-threaded, SIMD implementation sorts 64 million floating point numbers in less than 0.5 seconds on a commodity 4-core Intel processor. This measured performance compares favorably with all previously published results. Additionally, the paper demonstrates performance scalability of the proposed sorting algorithm with respect to certain salient architectural features of modern chip multiprocessor (CMP) architectures, including SIMD width and core-count. Based on our analytical models of various architectural configurations, we see excellent scalability of our implementation with SIMD width scaling up to 16X wider than current SSE width of 128-bits, and CMP core-count scaling well beyond 32 cores. Cycle-accurate simulation of Intel's upcoming x86 many-core Larrabee architecture confirms scalability of our proposed algorithm.
The Impact of Ethanol and Marinol/Marijuana Usage on HIV+/AIDS Patients Undergoing Azidothymidine, Azidothymidine/Dideoxycytidine, or Dideoxyinosine Therapy (1997)

Therapeutic observations suggest that azidothymidine (AZT)-resistant HIV+/AIDS patients are frequently offered AZT/dideoxycytidine (DDC) or dideoxyinosine (DDI) therapy. The latter therapies have been associated with the development of acute pancreatitis. During the initial portion of this study, when patients reported limiting ethanol consumption, an increase in CD4+, a decrease in amylase, and a decrease in lipase was observed in patients on DDI monotherapy. Marinol/marijuana usage was associated with depressed CD4+ counts and elevated amylase levels within the DDI subgroup. The purpose of this study was to follow these patients over 1 year and compare clinical indicators of pancreatitis and HIV progression. After 1 year, the remaining 56 patients were reexamined in the follow-up portion for clinical indicators of HIV disease progression and pancreatoxic/hepatotoxic effects. Those in the AZT group, who remained on this therapy throughout the year, had significantly increased amylase values from 55.3 to 69.3 IU/liter (p < 0.05). In the AZT/DDC group, those who remained on combination therapy throughout the year, 4 of the 5 clinical indicators of disease progression changed. Amylase, ALT, and AST all increased significantly from 55.2 to 77.8 IU/liter (p < 0.01), from 38.0 to 92.3 IU/liter (p < 0.05), and from 55.2 to 97.0 IU/liter (p < 0.05), respectively. Lipase levels decreased significantly (106.0 to 74.6 IU/liter, p < 0.05). The most remarkable changes occurred in the AZT/DDC group (who reduced ethanol consumption), wherein clinical indicators of pancreatitis and liver dysfunction declined, including amylase (65.0 to 20.0 IU/liter, p < 0.05), ALT (350.0 to 100.0 IU/liter, p < 0.01), and AST (240.0 to 95.0 IU/liter, p < 0.01). No significant changes were noted in the DDI or AZT groups. Marinol/marijuana use was associated with declining health status in both the AZT and AZT/DDC groups. In contrast, all clinical indicators of pancreatitis improved in the DDI patients who utilized Marinol/marijuana, including amylase (-34%), lipase (-30.8%), ALT (-21.4%), and AST (-20.1%). This paired follow-up study suggests that HIV+/AIDS patients on antiretroviral therapies should restrict their ethanol consumption. In HIV+/AIDS patients with the lowest CD4+ counts (those on DDI monotherapy), utilization of Marinol/marijuana does not seem to have a deleterious impact.
A Retroviral Oncogene, <i>akt</i> , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region (1991)

The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.
Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy (2005)

Fluorescence in situ hybridization (FISH) is more sensitive than conventional cytogenetics for recognizing chromosomal changes. Several FISH-detected abnormalities have been associated with inferior prognosis, including deletion of chromosomes 17 and 13 (Delta13) and t(4;14)(p16.3;q32). We analyzed the prognostic value of FISH testing in 238 patients who received high-dose therapy between January 1990 and September 2001. All patients had pretransplantation cytoplasmic immunoglobulin FISH done on cytospin slides from bone marrow aspirates for t(11;14), t(4;14), and -17(p13.1) (TP53). Time to progression and overall survival were significantly shorter for patients with t(4;14) and those with -17(p13.1) but were not affected by t(11;14). Overall survival was significantly shorter for patients with both t(4;14) and Delta13 abnormalities than for those with Delta13 alone (26.8 vs 18.8 months). In a multivariable analysis of the effect of Delta13 and t(4;14), the risk ratio for t(4;14) was greater than for Delta13 (2.6 vs 1.5). For high-dose therapy patients, -17(p13) and t(4;14) have clinical importance for estimating time to progression and overall survival. The presence of t(4;14) identifies a subset of patients whose time to progression is only 8.2 months. These patients receive minimal benefit from autologous stem cell transplantation and are candidates for novel therapeutic approaches.
Effects of Epimedium flavonoids on proliferation and differentiation of neural stem cells <i>in vitro</i> (2009)

The results demonstrate that EF effectively promotes the proliferation and differentiation of NSCs in vitro, suggesting that EF may have new properties of regulating central nervous system function by neurogenesis.
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein (2006)

Abstract Resveratrol is a naturally occurring phytoalexin with antioxidant and antiinflammatory properties. Recent studies suggest that resveratrol possesses anticancer effects, although its mechanism of action is not well understood. We now show that resveratrol inhibits Src tyrosine kinase activity and thereby blocks constitutive signal transducer and activator of transcription 3 (Stat3) protein activation in malignant cells. Analyses of resveratrol-treated malignant cells harboring constitutively-active Stat3 reveal irreversible cell cycle arrest of v-Src-transformed mouse fibroblasts (NIH3T3/v-Src), human breast (MDA-MB-231), pancreatic (Panc-1), and prostate carcinoma (DU145) cell lines at the G0-G1 phase or at the S phase of human breast cancer (MDA-MB-468) and pancreatic cancer (Colo-357) cells, and loss of viability due to apoptosis. By contrast, cells treated with resveratrol, but lacking aberrant Stat3 activity, show reversible growth arrest and minimal loss of viability. Moreover, in malignant cells harboring constitutively-active Stat3, including human prostate cancer DU145 cells and v-Src-transformed mouse fibroblasts (NIH3T3/v-Src), resveratrol treatment represses Stat3-regulated cyclin D1 as well as Bcl-xL and Mcl-1 genes, suggesting that the antitumor cell activity of resveratrol is in part due to the blockade of Stat3-mediated dysregulation of growth and survival pathways. Our study is among the first to identify Src-Stat3 signaling as a target of resveratrol, further defining the mechanism of antitumor cell activity of resveratrol and raising its potential application in tumors with an activated Stat3 profile. [Mol Cancer Ther 2006;5(3):621–9]
A Very Efficient Redundancy Analysis Method Using Fault Grouping (2013)

To increase device memory yield, many manufacturers use incorporated redundancy to replace faulty cells. In this redundancy technology, the implementation of an effective redundancy analysis (RA) algorithm is essential. Various RA algorithms have been developed to repair faults in memory. However, nearly all of these RA algorithms have low analysis speeds. The more densely compacted the memory is, the more testing and repair time is needed. Even if the analysis speed is very high, the RA algorithm would be useless if it did not have a normalized repair rate of 100%. In addition, when the number of added spares is increased in the memory, then the memory space that must be searched with the RA algorithms can exceed the memory space within the automatic test equipment. A very efficient RA algorithm using simple calculations is proposed in this work so as to minimize both the repair time and memory consumption. In addition, the proposed algorithm generates an optimal solution using a tree-based algorithm in each fault group. Our experiment results show that the proposed RA algorithm is very efficient in terms of speed and repair.
Von Wille‐brand's disease in UK dober‐manns: Possible correlation of a polymorphic DNA marker with disease status (1996)

Ninety-one dobermanns have been typed for a polymorphic microsatellite DNA marker situated within an intron of the von Willebrand factor gene and the alleles correlated with von Wille-brand's disease status. Two alleles were identified, one associated only with the normal gene and the other with both normal and disease genes.
Cost-Benefit Analysis of Public Clouds for Offloading In-House HPC Jobs (2018)

The Supercomputing Education and Research Centre (SERC) at the Indian Institute of Science (IISc), located in the South East Asian Region, has been providing state-of-the-art services and support for High Performance Computing (HPC) for the academic users of the institute since 1990. This centre, facilitates OpenMP, MPI, CUDA and OpenCL based HPC jobs for academic research. To augment or support the existing demand for compute intensive, tightly coupled HPC workloads in the institute, it was desirable to explore cloud based HPC services. This study is a comparative cost-benefit analysis of the in-house compute facility at SERC with that of the commercial cloud providers like Amazon, Google Cloud, Microsoft Azure and Sabalcore. The Total Cost of Ownership (TCO) of SahasraT (the in-house supercomputer) is computed and used to identify the cost of running a small job for 24 hours on the in-house facility. This is then compared with the estimated cost of running the same job on comparative cloud instances. Several research papers that provide a detailed evaluation of HPC on the cloud with performance benchmarks and the comparison to in-house HPC facilities, were studied. These references have been used to compare performance of compute instance in the public cloud to the performance of HPC at SahasraT. The results obtained in this study, advocate that current cloud platforms are expensive in both cost and performance as compared to the in-house facility at SERC
New<i>N</i>-Arachidonoylserotonin Analogues with Potential “Dual” Mechanism of Action against Pain (2007)

N-arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH) that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels and is analgesic in rodents. We modified the chemical structure of 1a with the aim of developing "hybrid" FAAH/TRPV1 blockers more potent than the parent compound or obtaining analogues with single activity at either of the two targets to study the mechanism of the analgesic action of 1a. Thirty-eight AA-5-HT analogues, containing a serotonin "head" bound to a variety of lipophilic moieties via amide, urea, or carbamate functionalities, were synthesized. Unlike 1a, most of the new compounds possessed activity at only one of the two considered targets. The amides 1b and 1c of alpha- and gamma-linolenic acid, however, showed "hybrid" activity similar to 1a. The carbamate 3f (OMDM106), although unable to antagonize TRPV1 receptors, was the most potent FAAH inhibitor in this study (IC50=0.5 microM). Compounds 3f and 1m (OMDM129), which exhibited activity at only FAAH or TRPV1, respectively, were 10-fold less potent than 1a at preventing formalin-induced hyperalgesia in mice.
Failure analysis of plastic encapsulated components—the advantages of IR microscopy* (1987)

SUMMARY This paper demonstrates that the use of an IR microscope in non‐destructive failure analysis of plastic encapsulated devices overcomes many of the problems previously associated with conventional failure analysis techniques. Moreover, the devices are amenable to subsequent examination and testing. Its advantages are highlighted in a number of case histories, concerning bond quality, corrosion and features of poor processing. The consequential modification to failure analysis methodology and its applicability to VLSI devices are discussed.
Unconventional Fracturing Fluids for Tight Gas Reservoirs (2009)

Abstract Many tight gas formations are water-wet and under-saturated where the initial water saturation in the reservoir is less than the capillary equilibrium irreducible water saturation. The use of water-based conventional fracturing fluids causes water to be trapped in the near-wellbore region, thereby significantly impairing the ability of gas to flow. Formations with sub-irreducible water saturation can be stimulated with fluids that minimize the interfacial tension (such as surfactant gels), minimize the amount of water used in the fluid (such as energized or foamed fluids), dehydrate the formation (such as alcohol-based fluids) or completely eliminate water (such as hydrocarbon-based or liquid carbon dioxide-based fluids). Since the rheology and proppant-carrying properties of these fluids vary, the uses of these fluids are different and will be discussed in detail in the paper. The paper will also present guidelines, based on formation properties, to indicate the need for considering unconventional fluids.
An anti‐acetylcholine receptor monoclonal antibody cross‐reacts with phosvitin (1983)

Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.
Stator Windings Fault Diagnostics of Induction Machines Operated From Inverters and Soft-Starters Using High-Frequency Negative-Sequence Currents (2009)

This paper studies the application of high-frequency voltage excitation-based stator winding diagnostic methods to three-phase ac machines operated from power converters that create the necessary high-frequency excitation as part of their normal operation. This paper focuses on two specific operating modes: 1) machines operated from inverters in the overmodulation region and 2) machines operated from soft-starters during startup. In both cases, high-frequency (in the range of the hundred hertz) voltage components at well-defined frequencies are created. The negative-sequence currents induced from these high-frequency voltages are shown to contain accurate information on the level of asymmetry (fault) in the machine. This information is significantly richer than exists in other modes of operation, i.e., inverters working in the linear modulation region or soft-starters in the steady state, and provides interesting opportunities to complement other diagnostic methods.
Structure of molten 1,3-dimethylimidazolium chloride using neutron diffraction (2002)

The model room temperature ionic liquid, 1,3-dimethylimidazolium chloride, has been studied by neutron diffraction for the first time. The diffraction data are used to derive a structural model of this liquid using Empirical Potential Structure Refinement. The model obtained indicates that significant charge ordering is present in the liquid salt and that the local order in this liquid closely resembles that found in the solid state. As in the crystal structure, hydrogen-bonding interactions between the ring hydrogens and the chloride dominate the structure. The model is compared with the data reported previously for both simple alkyl substituted imidazolium halides and binary mixtures with AlCl3.
S-1: a promising new oral fluoropyrimidine derivative (2009)

S-1 is an oral fluoropyrimidine that is designed to improve the antitumor activity of 5-fluorouracil (5-FU) concomitantly with an intent to reduce its toxicity. S-1 consists of tegafur, a prodrug of 5-FU combined with two 5-FU biochemical modulators:5-chloro-2,4-dihydroxypyridine (gimeracil or CDHP), a competitive inhibitor of dihydropyrimidine dehydrogenase and oteracil potassium which inhibits phosphorylation of 5-FU in the gastrointestinal tract decreasing serious gastrointestinal toxicities,including nausea, vomiting, stomatitis and diarrhea. Being an oral agent, S-1 offers convenience of administration and prevents complications of central venous access such as infection, thrombosis and bleeding. S-1 has shown efficacy in both gastrointestinal as well non-gastrointestinal malignancies. The authors review the current literature and provide their expert opinion on the incorporation of S-1 in the treatment of solid malignancies [corrected].