gebhart/patrepeval huggingface dataset:
TRANSIENT BACTEREMIA AND ENDOCARDITIS PROPHYLAXIS. A REVIEW (1977)

From the Infectious Disease Service, Brooke Army Medical Center, Fort Sam Houston, Texas 78234, and the Seattle Veterans Administration Hospital, University of Washington Medical School, Seattle, Washington. The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense. Requests for reprints: E. Dale Everett, LTC, MC, Chief, Infectious Disease Service, Post Office Box 474, Brooke Army Medical Center, Fort Sam Houston, Texas 78234.
Gadolinium as a neutron capture therapy agent (1992)

The clinical results of treating brain tumors with boron neutron capture therapy are very encouraging. Researchers around the world are once again making efforts to develop this therapeutic modality. Gadolinium-157 is one of the nuclides that holds interesting properties of being a neutron capture therapy agent. It is estimated that tumor concentrations of up to 300 micrograms 157 Gd/g tumor can be achieved in brain tumors with some MRI contrast agents such as Gd-DTPA and Gd-DOTA, and up to 800 micrograms 157 Gd/g tumor can be established in bone tumors with Gd-EDTMP. Monte Carlo calculations indicate that with 250 ppm of 157Gd in tumor, neutron capture therapy can deliver 2000 cGy to a tumor of 2-cm diameter or larger with 5 x 10(12) n/cm2 of thermal neutron fluence at the tumor. Dose measurements with films and TLDs in phantoms verified these calculations. More extended Monte Carlo calculations demonstrate that neutron capture therapy with Gd possesses comparable dose distribution to B neutron capture therapy. With 5 x 10(12) n/cm2 thermal neutrons at the tumor, Auger electrons from the Gd produced an optical density enhancement on films that is similar to the effect caused by about 300 cGy of Gd prompt gamma dose and may further enhance the therapeutic effects.
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis (2012)

The chemokine receptor CXCR2 is a key mediator of neutrophil migration that also plays a role in tumor development. However, CXCR2 influences tumors through multiple mechanisms and might promote or inhibit tumor development depending on context. Here, we used several mouse models of spontaneous and inflammation-driven neoplasia to define indispensable roles for CXCR2 in benign and malignant tumors. CXCR2-activating chemokines were part of the secretome of cultured primary benign intestinal adenomas (ApcMin/+) and highly expressed by all tumors in all models. CXCR2 deficiency profoundly suppressed inflammation-driven tumorigenesis in skin and intestine as well as spontaneous adenocarcinoma formation in a model of invasive intestinal adenocarcinoma (AhCreER;Apcfl/+;Ptenfl/fl mice). Pepducin-mediated CXCR2 inhibition reduced tumorigenesis in ApcMin/+ mice. Ly6G+ neutrophils were the dominant source of CXCR2 in blood, and CXCR2 deficiency attenuated neutrophil recruitment. Moreover, systemic Ly6G+ cell depletion purged CXCR2-dependent tumor-associated leukocytes, suppressed established skin tumor growth and colitis-associated tumorigenesis, and reduced ApcMin/+ adenoma formation. CXCR2 is thus a potent protumorigenic chemokine receptor that directs recruitment of tumor-promoting leukocytes into tissues during tumor-inducing and tumor-driven inflammation. Similar leukocyte populations were also found in human intestinal adenomas, which suggests that CXCR2 antagonists may have therapeutic and prophylactic potential in the treatment of cancer.
Design of a non-intrusive electrical impedance-based void fraction sensor for microchannel two-phase flows (2014)

A non-intrusive electrical impedance-based sensor is developed for measurement of local void fraction in air–water adiabatic flow through rectangular microchannels. Measurement of the void fraction in microchannels is essential for the formulation of two-phase flow heat transfer and pressure drop correlations, and may enable real-time flow regime control and performance prediction in the thermal regulation of high-heat-flux devices. The impedance response of the sensor to a range of flow regimes is investigated for a configuration with two aligned electrodes flush-mounted on opposing microchannel walls. Numerical simulations performed on a multi-phase domain constructed from three-dimensional reconstruction of experimentally observed phase boundaries along with the corresponding experimental results serve to establish the relationship between void fraction and dimensionless impedance for this geometric configuration. A reduced-order analytical model developed based on an assumption of stratified gas–liquid flow allows ready extension of these calibration results to different working fluids of interest.
A fast method for real-time median filtering (1980)

A fast real-time algorithm is presented for median filtering of signals and images. The algorithm determines the kth bit of the median by inspecting the k most significant bits of the samples. The total number of full-word comparison steps is equal to the wordlength of the samples. Speed and hardware complexity of the algorithm is compared with two other fast methods for median filtering.
Is Ki-67 a better proliferative marker in the colon than proliferating cell nuclear antigen? (1997)

Endogenous markers of proliferating cells have increasingly supplanted the use of incubation of biopsy tissues in vitro with tritiated thymidine or with bromodeoxyuridine, thus avoiding the potential variation resulting from the incubation procedure. Antibodies to proliferating cell nuclear antigen (PCNA) such as PC10 have been promoted as optimal for this purpose, although considerable variation in colonic proliferating cells with this antibody has been reported. We have compared the detection of colonic proliferating cells in normal mucosa and adenomata using the PC10 monoclonal antibody (mAb) to PCNA and the Mib-1 mAb to Ki-67 in formalin-fixed tissues using antigen retrieval solutions with microwaving. The PC10 antibody showed variable immunostaining of proliferating and nonproliferating cells with minor changes in primary antibody concentration or microwave conditions and between normal and adenomatous tissue. In contrast, Mib-1 immunostaining was quite constant with differing antigen retrieval and antibody conditions and similar staining of proliferating cells in colonic adenomas. Some loss of immunoreactivity occurred if the cut sections were not immunostained within approximately 1 week. These data suggest that whereas PCNA immunohistochemistry is satisfactory when carefully controlled in large chemopreventive studies, the Mib-1 mAb to Ki-67 is superior to PCNA antibodies in immunostaining proliferating cells in the formalin-fixed human colon.
Anomaly detection of time series. (2010)

University of Minnesota M.S. thesis. May 2010. Major: Computer Science. Advisor: Prof.Vipin Kumar. 1 computer science (PDF); vi, 75 pages. Ill. (some col.)
Neutrophil cannibalism triggers transforming growth factor β1 production and self regulation of neutrophil inflammatory function in monosodium urate monohydrate crystal–induced inflammation in mice (2012)

Neutrophil cannibalism and TGFβ1 production have the potential to make a significant contribution to the controlled resolution of neutrophil-driven inflammatory diseases such as gout.
The ATNF Pulsar Catalog (2004)

The number of known pulsars has significantly increased over the past few years. We have searched the literature to find papers announcing the discovery of pulsars or giving improved parameters for them. Data from the papers have been entered into a new pulsar catalog that can be accessed via a web interface or from the command line (on Solaris or Linux machines). The user may request over 120 different parameters, select pulsars of interest, generate custom variables and choose between different ways of displaying or tabulating the datA. Full bibliographic references are available for all observed parameters.
Non-linear Analysis of Intracranial Electroencephalogram Recordings with Approximate Entropy and Lempel-Ziv Complexity for Epileptic Seizure Detection (2007)

Epileptic seizures are generated by an abnormal synchronization of neurons unforeseeable for the patients. In this study we analyzed invasive electroencephalogram (EEG) recordings in patients suffering from medically intractable focal epilepsy with two non-linear methods, Approximate Entropy (ApEn) and Lempel-Ziv (LZ) complexity. ApEn and LZ complexity quantify the regularity and complexity of a time series, respectively, and are well suited to the analysis of non-stationary biomedical signals of short length. Our results show an increase in ApEn and LZ complexity values during seizures at the focal electrodes. These changes could also be seen at some extra focal electrodes. After the seizure ends, the values of both non-linear metrics return to values lower than those before the seizure. Moreover, we quantified the changes in LZ complexity, showing the complexity increase during the seizure and its notable decrease after its end. Our results suggest that these techniques are useful to detect changes due to epileptic seizures in the EEG.
Prospects for Developing an Effective Vaccine Against Ocular Herpes Simplex Virus Infection (2005)

One of the hallmarks of herpes simplex virus (HSV) infection is the establishment of a lifelong latent infection accompanied by periods of recurrent disease. Primary HSV infections or repeated clinical recurrences do not elicit immune responses capable of completely preventing recurrences of endogenous virus. It is therefore questionable if vaccination approaches that seek to mimic the immune response to natural infection will reduce infection or disease due to an exogenous viral challenge. Approaches to the induction of protective responses by altering or enhancing both innate and adaptive immunity, using novel vaccines specifically tested in models of HSV infections of the eye, such as recombinant viral vaccine vectors and DNA vaccines, are detailed in this review.
Steroids. CCCX. Structure-activity relation of some steroidal hypnotic agents (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroids. CCCX. Structure-activity relation of some steroidal hypnotic agentsLaszlo Gyermek, Jose Iriarte, and Pierre CrabbeCite this: J. Med. Chem. 1968, 11, 1, 117–125Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/jm00307a026https://doi.org/10.1021/jm00307a026research-articleACS PublicationsRequest reuse permissionsArticle Views221Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wireless Access for Vehicular Environments (2011)

basic technologies used in this standard, also proposes some limitations and applications of this criteria. Based on this, this report focuses on two limitations: real-time communication constraints and unfairness dedication of channel with using distributed coordination function on Medium Access Control (MAC) layer. Some ideas for improving these limitations are raised with the results of simulations. For the real-time problem, a Time Division Multiple Access (TDMA) MAC layer is studied and evaluated. For the unfairness dedication of channel problem, a priority is given to each node of different speed to achieve a dynamic contention window size. The result of simulation shows this method efficiently improves this limitation.
Falls event detection using triaxial accelerometry and barometric pressure measurement (2009)

A falls detection system, employing a Bluetooth-based wearable device, containing a triaxial accelerometer and a barometric pressure sensor, is described. The aim of this study is to evaluate the use of barometric pressure measurement, as a surrogate measure of altitude, to augment previously reported accelerometry-based falls detection algorithms. The accelerometry and barometric pressure signals obtained from the waist-mounted device are analyzed by a signal processing and classification algorithm to discriminate falls from activities of daily living. This falls detection algorithm has been compared to two existing algorithms which utilize accelerometry signals alone. A set of laboratory-based simulated falls, along with other tasks associated with activities of daily living (16 tests) were performed by 15 healthy volunteers (9 male and 6 female; age: 23.7 +/- 2.9 years; height: 1.74 +/- 0.11 m). The algorithm incorporating pressure information detected falls with the highest sensitivity (97.8%) and the highest specificity (96.7%).
Living ring-opening metathesis polymerization of 2,3-difunctionalized norbornadienes by Mo(:CHBu-tert)(:NC6H3Pr-iso2-2,6)(OBu-tert)2 (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiving ring-opening metathesis polymerization of 2,3-difunctionalized norbornadienes by Mo(:CHBu-tert)(:NC6H3Pr-iso2-2,6)(OBu-tert)2G. C. Bazan, E. Khosravi, Richard R. Schrock, W. J. Feast, V. C. Gibson, M. B. O'Regan, J. K. Thomas, and W. M. DavisCite this: J. Am. Chem. Soc. 1990, 112, 23, 8378–8387Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/ja00179a023https://doi.org/10.1021/ja00179a023research-articleACS PublicationsRequest reuse permissionsArticle Views1738Altmetric-Citations353LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Inhibition of Pulmonary Eosinophilia and Hyperreactivity by Antibodies to lnterleukin-5 (1995)

Eosinophils infiltrate into the lungs during asthma and may cause the damage associated with pulmonary inflammation. In allergic animal models, antibodies to interleukin (IL)-5 inhibit pulmonary eosinophilia, tissue damage and hyperreactivity. Sch 55700, a humanized antibody against human IL-5, inhibits eosinophilia in these models with an extended biological duration. On the basis of this dosing regimen and the humanized nature of Sch 55700, it is anticipated that the host response leading to tolerance would be minimized.
Chromatic transition of polydiacetylene in solution (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleChromatic transition of polydiacetylene in solutionBenjamin Chu and Renliang XuCite this: Acc. Chem. Res. 1991, 24, 12, 384–389Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ar00012a005https://doi.org/10.1021/ar00012a005research-articleACS PublicationsRequest reuse permissionsArticle Views407Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Distinctive DNA conformation with enlarged major groove is found in Zn-finger-DNA and other protein-DNA complexes. (1994)

We have analyzed DNA conformations in a series of protein-DNA complexes, and we find that a distinctive conformation--with an enlarged major groove--occurs in a number of different complexes. During this analysis, we also developed a simplified model of DNA structure that illustrates the relative position of (i) the base pairs, (ii) the phosphate backbone, and (iii) the double-helical axis. This model highlights the key structural features of each duplex, facilitating the analysis and comparison of structures that are distinct from canonical A-DNA or B-DNA. Comparing DNA conformations in this way revealed that an otherwise unrelated set of protein-DNA complexes have interesting structural similarities, including an enlarged major groove. We refer to this class of structures as Beg-DNA (where eg means enlarged groove). Since related features occur in such a diverse set of protein-DNA complexes, we suggest that this conformation may have a significant role in protein-DNA recognition.
Electrophysiology Meets Printed Electronics: The Beginning of a Beautiful Friendship (2019)

Electroencephalography and surface electromyography are notoriously cumbersome technologies. A typical setup may involve bulky electrodes, dangling wires, and a large amplifier unit. Adapting these technologies to numerous applications has been accordingly fairly limited. Thanks to the availability of printed electronics, it is now possible to effectively simplify these techniques. Elegant electrode arrays with unprecedented performances can be readily produced, eliminating the need to handle multiple electrodes and wires. Specifically, in this Perspective paper, we focus on the advantages of electrodes printed on soft films as manifested in signal transmission at the electrode-skin interface, electrode-skin stability, and user convenience during electrode placement while achieving prolonged use. Customizing electrode array designs and implementing blind source separation methods can also improve recording resolution, reduce variability between individuals and minimize signal cross-talk between nearby electrodes. Finally, we outline several important applications in the field of neuroscience and how each can benefit from the convergence of electrophysiology and printed electronics.
A genomic view of immunology (2001)

The outstanding problems facing immunology are whole system issues: curing allergic and autoimmune disease and developing vaccines to stimulate stronger immune responses against pathogenic organisms and cancer. We hope that the human genome sequence will reveal the molecular checks and balances that ensure both an effective immunogenic response against pathogenic microorganisms and a suitably tolerogenic response to self antigens and innocuous environmental antigens. Three synergistic approaches--sequence homology searches, messenger RNA expression profiling on microarrays, and mutagenesis in mice--provide the best opportunities to reveal, in the genome sequence, key proteins and pathways for targeting by new immunomodulatory treatments.
Myostatin Regulates Cardiomyocyte Growth Through Modulation of Akt Signaling (2006)

Myostatin is a highly conserved, potent negative regulator of skeletal muscle hypertrophy in many species, from rodents to humans, although its mechanisms of action are incompletely understood. Transcript profiling of hearts from a genetic model of cardiac hypertrophy revealed dramatic upregulation of myostatin, not previously recognized to play a role in the heart. Here we show that myostatin abrogates the cardiomyocyte growth response to phenylephrine in vitro through inhibition of p38 and the serine-threonine kinase Akt, a critical determinant of cell size in many species from drosophila to mammals. Evaluation of male myostatin-null mice revealed that their cardiomyocytes and hearts overall were slightly smaller at baseline than littermate controls but exhibited more exuberant growth in response to chronic phenylephrine infusion. The increased cardiac growth in myostatin-null mice corresponded with increased p38 phosphorylation and Akt activation in vivo after phenylephrine treatment. Together, these data demonstrate that myostatin is dynamically regulated in the heart and acts more broadly than previously appreciated to regulate growth of multiple types of striated muscle.
Plutonium Immobilization Project Baseline Formulation (1999)

A key milestone for the Immobilization Project (AOP Milestone 3.2a) in Fiscal Year 1998 (FY98) is the definition of the baseline composition or formulation for the plutonium ceramic form. The baseline formulation for the plutonium ceramic product must be finalized before the repository- and plant-related process specifications can be determined. The baseline formulation that is currently specified is given in Table 1.1. In addition to the baseline formulation specification, this report provides specifications for two alternative formulations, related compositional specifications (e.g., precursor compositions and mixing recipes), and other preliminary form and process specifications that are linked to the baseline formulation. The preliminary specifications, when finalized, are not expected to vary tremendously from the preliminary values given.
Multiple description coding for scalable video coding with redundant slice (2012)

Scalable video coding(SVC) is designed to provide adaptable capability for heterogeneous network structures with its scalabilities. Due to the introducing of inter-layer prediction, SVC coded bitstream is much vulnerable to the channel error. To solve this problem, a lot of schemes are proposed. However, they are either not compatible with the standard or just focus on one of scalabilities in SVC. In this paper, we propose a multiple description scheme that is compatible with SVC standard and supports all the scalabilities. The proposed scheme is based on the redundant slice in the SVC standard, in which each layer is composed of primary slice and redundant slice by interleaving. To deal with the mismatch error and propagated error, the quantization step of redundant slice and the mode of each macroblock is tuned by considering the prediction path in the same layer and between different layers, as well as the channel packet loss rate. The experimental results show that the proposed scheme is efficient for the packet loss channel.