gebhart/patrepeval huggingface dataset:
An Introduction to Combustion: Concepts and Applications (2000)

Preface Preface to the Second Edition Preface to the First Edition 1: Introduction 2: Combustion and Thermochemistry 3: Introduction to Mass Transfer 4: Chemical Kinetics 5: Some Important Chemical Mechanisms 6: Coupling Chemical and Thermal Analyses of Reacting Systems 7: Simplifed Conversation Equations for Reacting Flows 8: Laminar Premixed Flames 9: Laminar Diffusion Flames 10: Droplet Evaporation and Burning 11: Introduction to Turbulent Flows 12: Turbulent Premixed Flames 13: Turbulent Nonpremixed Flames 14: Burning of Solids 15: Pollutant Emissions 16: Detonations Appendix A: Selected Thermodynamic Propertiesof Gases Comprising C-H-O-N System Appendix B: Fuel Properties Appendix C: Selected Properties of Air, Nitrogen, and Oxygen Appendix D: Diffusion Coefficients and Methodology for their Estimation Appendix E: Generalized Newton's Method for the Solution of Nonlinear Equations Appendix F: Computer Codes for Equilibrium Products of Hydrocarbon-Air Combustion
Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome (2009)

During June to August 2009 in Australia and New Zealand, the ICUs at regional referral centers provided mechanical ventilation for many patients with 2009 influenza A(H1N1)-associated respiratory failure, one-third of whom received ECMO. These ECMO-treated patients were often young adults with severe hypoxemia and had a 21% mortality rate at the end of the study period.
Inhibition of platelet‐derived growth factor receptorβ by imatinib mesylate suppresses proliferation and alters differentiation of human mesenchymal stem cells <i>in vitro</i> (2007)

In summary, inhibition of PDGFRbeta and downstream Akt and Erk signalling by IM has a significant impact on proliferation and differentiation of human MSC in vitro.
Azulene based metal–organic frameworks for strong adsorption of H <sub>2</sub> (2010)

Two Zn MOFs, MOF-645 and MOF-646, comprised of polarized 1,3-azulenedicarboxylate were synthesized. The guest free MOF-646 showed strong MOF-H(2) interactions (7.8-6.8 kJ mol(-1)), which revealed the significant impact of internally polarized azulene backbone to stabilized H(2) molecules in the framework.
Hypertension Caused by Angiotensin II Infusion Involves Increased Superoxide Production in the Central Nervous System (2004)

Hypertension caused by angiotensin II (Ang II) infusion is associated with oxidative stress in the peripheral vasculature and kidney. The role of redox mechanisms in the central nervous system (CNS), a tissue known to be pivotal in Ang II-dependent hypertension, has not been investigated. We recently identified superoxide (O2*-) in the brain as a key signaling intermediate in the transient pressor response elicited by acute injection of Ang II directly into the CNS. Here we tested the hypothesis that hypertension caused by chronic systemic infusion of Ang II is mediated by a central neurogenic mechanism involving O2*-. Infusion of Ang II (600 ng x kg(-1) x min(-1)) over a 2-week period in mice caused a gradually developing hypertension that was correlated with marked elevations in O2*- production specifically in the subfornical organ (SFO), a brain region lying outside the blood-brain barrier and known to be a primary sensor for blood-borne Ang II. Adenoviral-mediated delivery of cytoplasmically targeted superoxide dismutase (SOD) selectively to this site prevented the hypertension and the increased O2*- production, whereas gene transfer of SOD targeted to the extracellular matrix had no effect. These data suggest that increased intracellular O2*- production in the SFO is critical in the development of Ang II-induced hypertension.
A double-blind placebo-controlled study of vitamin E treatment of tardive dyskinesia. (1996)

Vitamin E appears to be effective in reducing the severity of TD, especially in patients who have had TD for 5 years or less.
Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study (2010)

Cucurbit[n]urils (CB[n]) are potential stabilizing, solubilizing, activating, and delivering agents for drugs. The toxicity of the macrocyclic host molecules cucurbit[7]uril (CB[7]), the most water-soluble homologue, as well as cucurbit[8]uril (CB[8]) has been evaluated. In vitro studies on cell cultures revealed an IC(50) value of 0.53 +/- 0.02 mM for CB[7], corresponding to around 620 mg of CB[7] per kg of cell material. Live-cell imaging studies performed on cells treated with subtoxic amounts of CB[7] showed no detrimental effects on the cellular integrity as assessed by mitochondrial activity. For CB[8], no significant cytotoxicity was observed within its solubility range. The bioadaptability of the compounds was further examined through in vivo studies on mice, where intravenous administration of CB[7] showed a maximum tolerated dosage of 250 mg kg(-1), while oral administration of a CB[7]/CB[8] mixture showed a tolerance of up to 600 mg kg(-1). The combined results indicate a sufficiently low toxicity to encourage further exploration of CB[n] as additives for medicinal and pharmaceutical use.
Change in the expression of a nuclear matrix-associated protein is correlated with cellular transformation. (1991)

We have identified a monoclonal antibody that recognizes a nuclear matrix-associated protein in NIH 3T3 cells. The immunofluorescence pattern consists predominantly of bright nuclear granule clusters distributed throughout the nucleoplasm, with the exclusion of nucleoli. It recognizes a protein of 190 kDa that is down-regulated to various degrees in a panel of single-oncogene-transformed NIH 3T3 cells. Its localization is similar, but not identical, to the spliceosomal speckles. p190 shows a coordinate expression during the growth cycle of nontransformed NIH 3T3 cells; it is synthesized at the highest level under growth arrest conditions. It is expressed in adult mouse brain and is also present in human IMR-90 fibroblasts.
Post-herpetic neuralgia: the relation of pain complaint, sensory disturbance and skin temperature (1989)

Twelve otherwise healthy patients with longstanding postherpetic neuralgia (PHN) were prospectively studied using clinical examination, infrared thermography and response to local anesthetic skin infiltration. All had at least 2 of 3 possible components to their PHN pain: continuous, neuralgic, or allodynic. In patients with allodynia, maximal reported pain and the location of maximal allodynia on sensory examination were largely overlapping and were often warm thermographically. Areas of dense sensory loss and skin scarring without allodynia were usually cool thermographically. Local anesthetic skin infiltration produced substantial pain relief in all 9 patients (essentially complete relief in 7) with allodynia: the 3 patients with predominantly continuous pain were not relieved. In 7 of 8 skin infiltration responders, the same dose of lidocaine i.m. in the deltoid muscle also produced significant, though less complete pain relief. These results suggest that PHN patients can be divided into at least 2 clinical groups: those with predominantly continuous pain localized to a region of significant sensory loss and those in whom allodynia is the most prominent sensory disturbance. The latter group has pain localized to areas with relatively preserved sensation. The differences in clinical features and response to lidocaine suggest that there are at least 2 different mechanisms contributing to the pain of PHN.
Na-doped Ni-rich LiNi<sub>0.5</sub>Co<sub>0.2</sub>Mn<sub>0.3</sub>O<sub>2</sub>cathode material with both high rate capability and high tap density for lithium ion batteries (2014)

Na-doped Ni-rich LiNi0.5Co0.2Mn0.3O2 cathode material, Li0.97Na0.03Ni0.5Co0.2Mn0.3O2, is synthesized by a hydroxide co-precipitation route. The structural characterization reveals that the substitution of Na for Li results in a more ordered α-NaFeO2 structure, enlarges Li layer spacing, and reduces the degree of cation mixing. The Li0.97Na0.03Ni0.5Co0.2Mn0.3O2 material has a high tap density of 2.17 g cm(-3) that meets the commercial requirement in lithium ion batteries (LIBs). The galvanostatic charge/discharge results show that the electrochemical performance of the Li0.97Na0.03Ni0.5Co0.2Mn0.3O2 is significantly improved. At 0.2, 1, 10, 30 and 50 C, the specific capacities of the Li0.97Na0.03Ni0.5Co0.2Mn0.3O2 are 228.43, 163.12, 121.43, 95.56 and 60.09 mA h g(-1), respectively, which are superior to those of the undoped LiNi0.5Co0.2Mn0.3O2 due to the enlargement of Li layer spacing, the decreased degree of cation mixing, and the rapid diffusion of Li-ion in the bulk lattice after the substitution of Na for Li. Therefore, the Na-doped Ni-rich LiNi0.5Co0.2Mn0.3O2 material is a promising cathode candidate for the next generation of LIBs.
Outcome in patients with profound biotinidase deficiency: relevance of newborn screening (2004)

Profound biotinidase deficiency (PBD) is an autosomal recessively inherited disorder of biotin metabolism, which can be detected by newborn screening and treated with biotin supplementation. Children were investigated in whom PBD was detected by newborn screening and who were treated presymptomatically, or who were not screened but were diagnosed and treated after experiencing initial clinical symptoms (symptomatic children). In a follow-up of our study group, differences in development, social and behavioural adaptation, and signs of residual impairment were examined. Parents and physicians of children with PBD completed questionnaires which included the Child Behavior Checklist and Vineland Adaptive Behavior Scales. Information was obtained for 37 children (24 males, 13 females; median age at recruitment 6 years 8 months, range to 6 months-20 years; median length of follow-up 6 years 6 months, range 5 months to 18 years 3 months). All 11 symptomatic children had residual enzyme activity of <1%, or variants of the Michaelis-Menten constant which were not detected by newborn screening. Some symptomatic children showed residual impairments: hearing impairment (n=2), optic atrophy (n=2), both hearing impairment and optic atrophy (n=2). In addition, symptomatic children had a higher risk of delayed motor and speech development. No child with PBD detected by newborn screening (n=25) had auditory or visual loss; and milestones of speech development and motor skills were reached at an appropriate age. There was no significant difference in social adaptation or behavioural problems between symptomatic and asymptomatic children. Symptomatic children often have developmental delay and are at risk of irreversible damage to auditory, visual, or central nervous functions; whereas children with PBD (established presymptomatically following newborn screening) treated with biotin supplementation, do not experience these effects.
Chemistry and structure activity relationships of bafilomycin A1, a potent and selective inhibitor of the vacuolar H+-ATPase. (1999)

Bafilomycin A1, a macrolide antibiotic isolated from the fermentation of Streptomyces spp., is a potent and selective inhibitor of vacuolar-type proton translocating ATP-ases (V-ATPases) and was used to study the physiological role of this class of enzymes. An extensive chemical effort on the unusual structure of this macrolide led to the synthesis of significantly different bafilomycin derivatives. None of the new analogues was more potent than the parent compound but provided a significant amount of information about the structural requirements for the inhibitory activity of bafilomycin A1 in particular on chicken osteoclast (cOc) ATPase. The vinylic methoxy group adjacent to a carbonyl function, the dienic system and the hydroxy group at position 7 were recognized to be essential features for bafilomycin V-ATPase-inhibitory activity. This information was utilized to design simplified novel derivatives as inhibitors of bone resorption.
Cell-free translation of carbamyl phosphate synthetase I and ornithine transcarbamylase messenger RNAs of rat liver. Effect of dietary protein and fasting on translatable mRNA levels. (1981)

Total RNA of rat liver was translated in a cell-free system derived from rabbit reticulocytes, and synthesized precursor forms of carbamyl phosphate synthetase I (EC 6.3.4.16) and ornithine transcarbamylase (EC 2.1.3.2) were isolated by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis.Synthesis of both enzyme precursors was optimal with 90 to 180 m M potassium ion, 1.2 m M magnesium, and 50 pg/ml of rat liver tRNA.Enzyme synthesis increased with total RNA up to 1.2 mg/ml and with time up to 90 min at 25 "C.Translatable levels of hepatic mRNAs for carbamyl phosphate synthetase I and ornithine transcarbamylase were 4.2-and 2.2-fold higher, respectively, in the case of rats fed a 60% casein diet as compared with rats fed a 5% casein diet.The differences in mRNA levels were slightly higher than the differences in the levels of the enzyme activities (3.3-and 1.9fold, respectively) and of the enzyme proteins (3.3-and 2.l-fold, respectively).The results indicate that the dietary protein-dependent changes in the levels of carbamyl phosphate synthetase I and ornithine transcarbamylase are due mainly to changes in levels of translatable mRNAs for the enzymes.The hepatic levels of the two enzymes expressed per g wet weight of liver were also increased 1.7-and 1.3-fold, respectively, during a 7-day fasting over those of control animals kept on a 24% protein diet.However, the levels of translatable mRNAs for carbamyl phosphate synthetase I and ornithine transcarbamylase were decreased to 54 and 6796, respectively, of those of the control animals.Thus, the increase of the two enzyme levels during fasting appears to be the result of a decreased rate of degradation of the enzymes.Carbamyl phosphate synthetase I (EC 6.3.4.16) and ornithine transcarbamylase (EC 2.1.3.2) catalyze the first two steps of urea synthesis in the liver of ureotelic animals.T h e former enzyme consists of two identical subunits of M , = 156,000-160,000 (1-4), is located in the mitochondrial matrix ( 5 ) , and constitutes 20-30% of total matrix protein (2, 6).Ornithine transcarbamylase is a trimer of identical subunits
Reconstruction of signals from their autocorrelation and cross-correlation vectors, with applications to phase retrieval and blind channel estimation (2016)

We consider the problem of reconstructing two signals from the autocorrelation and cross-correlation measurements. This inverse problem is a fundamental one in signal processing, and arises in many applications, including phase retrieval and blind channel estimation. In a typical phase retrieval setup, only the autocorrelation measurements are obtainable. We show that, when the measurements are obtained using three simple "masks", phase retrieval reduces to the aforementioned reconstruction problem. The classic solution to this problem is based on finding common factors between the $z$-transforms of the autocorrelation and cross-correlation vectors. This solution has enjoyed limited practical success, mainly due to the fact that it is not sufficiently stable in the noisy setting. In this work, inspired by the success of convex programming in provably and stably solving various quadratic constrained problems, we develop a semidefinite programming-based algorithm and provide theoretical guarantees. In particular, we show that almost all signals can be uniquely recovered by this algorithm (up to a global phase). Comparative numerical studies demonstrate that the proposed method significantly outperforms the classic method in the noisy setting.
Potentiation of Thromboxane A2-induced Platelet Secretion by Gi Signaling through the Phosphoinositide-3 Kinase Pathway (2001)

Platelet activation results in shape change, aggregation, generation of thromboxane A2, and release of granule contents. We have recently demonstrated that secreted ADP is essential for thromboxane A2-induced platelet aggregation (J. Biol. Chem. 274: 29108-29114, 1999). The aim of this study was to investigate the role of secreted ADP interacting at P2 receptor subtypes in platelet secretion. Platelet secretion induced by the thromboxane A2 mimetic U46619 was unaffected by adenosine-3'phosphate-5'-phosphate, a P2Y1 receptor selective antagonist. However, AR-C66096, a selective antagonist of the P2T(AC) receptor, inhibited U46619-induced platelet secretion, indicating an important role for Gi signaling in platelet secretion. Selective activation of either the P2T(AC) receptor or the alpha2A adrenergic receptor did not cause platelet secretion, but potentiated U46619-induced platelet secretion. SC57101, a fibrinogen receptor antagonist, failed to inhibit platelet secretion, demonstrating that outside-in signaling was not required for platelet secretion. Since Gi signaling results in reduction of basal cAMP levels through inhibition of adenylyl cyclase, we investigated whether this is the signaling event that potentiates platelet secretion. SQ22536 or dideoxyadenosine, inhibitors of adenylyl cyclase, failed to potentiate U46619-induced primary platelet secretion, indicating that reduction in cAMP levels does not directly contribute to platelet secretion. Wortmannin, a selective inhibitor of PI-3 kinase, minimally inhibited U46619-induced platelet secretion when it was solely mediated by Gq, but dramatically ablated the potentiation of Gi signaling. We conclude that signaling through the P2T(AC) receptor by secreted ADP causes positive feedback on platelet secretion through a PI-3 kinase pathway.
Wear testing of materials and surfaces for total knee replacement (1996)

A simple wear test was investigated for evaluating the wear and damage of material pairs when used in total knee replacement. The test consisted of an axially loaded metallic femoral indentor and a reciprocating ultrahigh molecular weight polyethylene (UHMWPE) flat disk that represented the tibial component. A number of variables were studied including the effect of conformity by varying the radii of the femoral surface, distilled water or serum as a lubricant, different femoral materials, and different types of UHMWPE. In general, the different morphologies of the surface wear of the UHMWPE were similar to those seen on retrieved total knee replacements. Increased conformity with a cylindrical indentor gave a reduced wear rate initially, compared with that of the lower conformity spherical indentor. However, the wear rates were similar subsequent to this initial wearing in phase. Transfer films of UHMWPE were observed on the cobalt-chrome indentors for both serum and distilled water lubrication, although this film was more extensive for distilled water. The lowest wear rate was observed when oxidized zirconium was used on the femoral side, which was attributed to greater wettability, surface hardness, and immunity to oxidative wear. Tests using cobalt-chrome femoral cylinders and different grades of UHMWPE showed different wear rates. Of these PEs, GUR 415 showed less wear than both RCH 1000 and UHMWPE containing numerous fusion defects. For the latter, wear was attributed to a fatigue mechanism, although in most cases it was associated with surface phenomena rather than subsurface cracking. However, in some specimens of UHMWPE subsurface crack propagations occurred with defects. The test method is discussed in relation to its applicability to the evaluation and comparison of bearing materials and surfaces, with particular application to total knee replacements.
Interferon-γ Induces Downregulation of Tangier Disease Gene (ATP-Binding-Cassette Transporter 1) in Macrophage-Derived Foam Cells (2000)

Cholesterol efflux is a fundamental process that serves to mitigate cholesterol accumulation and macrophage foam cell formation. Recently, we reported that cholesterol efflux to high density lipoprotein subfraction 3 was reduced by interferon-gamma (IFN-gamma) and that this decrease was associated with an increase in acyl coenzyme A:cholesterol acyltransferase (ACAT) expression. In the present study, although treatment of murine peritoneal macrophages with IFN-gamma resulted in a 2-fold decrease in HDL-mediated cholesterol efflux, efflux to lipid-free apolipoprotein A-I was reduced >4-fold and approached basal levels. This decrease was associated with a 3- to 4-fold reduction in ATP-binding-cassette transporter 1 (ABC1) mRNA content, the gene responsible for the defect in Tangier disease. Consistent with the reduction in cholesterol and phospholipid efflux in Tangier fibroblasts, downregulation of ABC1 expression by IFN-gamma also resulted in reduced phosphatidylcholine and sphingomyelin efflux to apolipoprotein A-I. Whereas foam cells had a 3-fold increase in ABC1 mRNA, the decrease in ABC1 message levels by IFN-gamma was observed in foam cells and control macrophages. This effect of IFN-gamma was independent of general macrophage activation (inasmuch as similar changes were not detected with granulocyte-macrophage colony-stimulating factor) and was not observed with other ABC transporters (inasmuch as the expression of the transporter in antigen processing was upregulated 4-fold in these same cells). Therefore, by decreasing cholesterol efflux through pathways that include the upregulation of ACAT and the downregulation of ABC1, IFN-gamma can shift the equilibrium between macrophages and foam cells and thus impact the progression of an atherosclerotic lesion.
Algebraic signatures for scalable distributed data structures (2004)

Signatures detect changes to data objects. Numerous schemes are in use, especially the cryptographically secure standards SHA-1. We propose a novel signature scheme which we call algebraic signatures. The scheme uses the Galois field calculations. Its major property is the sure detection of any changes up to a parameterized size. More precisely, we detect for sure any changes that do not exceed n-symbols for an n-symbol algebraic signature. This property is new for any known signature scheme. For larger changes, the collision probability is typically negligible, as for the other known schemes. We apply the algebraic signatures to the scalable distributed data structures (SDDS). We filter at the SDDS client node the updates that do not actually change the records. We also manage the concurrent updates to data stored in the SDDS RAM buckets at the server nodes. We further use the scheme for the fast disk backup of these buckets. We sign our objects with 4-byte signatures, instead of 20-byte standard SHA-1 signatures. Our algebraic calculus is then also about twice as fast.
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors (2008)

Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by introducing Oct3/4 and Sox2 with either Klf4 and c-Myc or Nanog and Lin28 using retroviruses or lentiviruses. Patient-specific iPS cells could be useful in drug discovery and regenerative medicine. However, viral integration into the host genome increases the risk of tumorigenicity. Here, we report the generation of mouse iPS cells without viral vectors. Repeated transfection of two expression plasmids, one containing the complementary DNAs (cDNAs) of Oct3/4, Sox2, and Klf4 and the other containing the c-Myc cDNA, into mouse embryonic fibroblasts resulted in iPS cells without evidence of plasmid integration, which produced teratomas when transplanted into mice and contributed to adult chimeras. The production of virus-free iPS cells, albeit from embryonic fibroblasts, addresses a critical safety concern for potential use of iPS cells in regenerative medicine.