gebhart/patrepeval huggingface dataset:
Carbon Nanotube Thin Films: Fabrication, Properties, and Applications (2010)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTCarbon Nanotube Thin Films: Fabrication, Properties, and ApplicationsLiangbing Hu*, David S. Hecht, and George Grüner*View Author Information Department of Physics, University of California Los Angeles, Los Angeles, California 90095* To whom correspondence should be addressed. E-mail: [email protected] (L.H.), [email protected] (G.G.).Cite this: Chem. Rev. 2010, 110, 10, 5790–5844Publication Date (Web):July 22, 2010Publication History Received2 September 2009Published online22 July 2010Published inissue 13 October 2010https://pubs.acs.org/doi/10.1021/cr9002962https://doi.org/10.1021/cr9002962review-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views31124Altmetric-Citations863LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbon nanotubes,Electrical conductivity,Electrodes,Thin films,Transistors Get e-Alerts
A framework for uncertainty-aware visual analytics (2009)

Visual analytics has become an important tool for gaining insight on large and complex collections of data. Numerous statistical tools and data transformations, such as projections, binning and clustering, have been coupled with visualization to help analysts understand data better and faster. However, data is inherently uncertain, due to error, noise or unreliable sources. When making decisions based on uncertain data, it is important to quantify and present to the analyst both the aggregated uncertainty of the results and the impact of the sources of that uncertainty. In this paper, we present a new framework to support uncertainty in the visual analytics process, through statistic methods such as uncertainty modeling, propagation and aggregation. We show that data transformations, such as regression, principal component analysis and k-means clustering, can be adapted to account for uncertainty. This framework leads to better visualizations that improve the decision-making process and help analysts gain insight on the analytic process itself.
Historical Overview of Transplantation (2013)

Except for legends and claims of miracles, most histories of transplantation cover only the last 60 years because there were no earlier successes. However, the story of even this era has been documented in such rich detail that a full account would fill several volumes. Thus, this brief summary must be limited to highly selected "landmarks." Some landmarks had an immediate impact, but the importance of others went unrecognized for decades. Some findings that deserved landmark status were overlooked or forgotten, whereas others of no biological significance had major impact. Placing these events in perspective is challenging. Several of transplantation's pioneers are still alive, and most of the others are within living memory. Virtually all of them have produced their own accounts. For the most part, they agree on what the "landmarks" are, but their differences in emphasis and perspective make an interesting story.
Sildenafil in the management of the failing Fontan circulation (2010)

Sildenafil can be used safely and effectively in the treatment of patients with a failing Fontan circulation.
Amine Additives Greatly Expand the Scope of Asymmetric Hydrosilylation of Imines (1998)

Slow addition of a primary amine to the reaction mixture greatly increases the scope of the titanium-catalyzed asymmetric reduction of imines 1. An important added feature of this method is that chiral secondary amines 2 can be obtained in much higher optical purity (up to 99 % ee) than would be predicted from the E:Z ratios of the starting imines 1.
Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan (2007)

Mesenchymal stem cells (MSC) are capable of differentiating into bone, fat, cartilage, tendon and other organ progenitor cells. Despite the abundance of MSC within the organism, little is known about their in vivo properties or about their corresponding in vivo niches. We therefore isolated MSC from spongy (cancellous) bone biopsies of healthy adults. When compared with the surrounding marrow, a fourfold higher number of colony-forming units was found within the tight meshwork of trabecular bone surface. At these sites, oxygen concentrations range from 1% to 7%. In MSC cultured at oxygen as low as 3%, rates for cell death and hypoxia-induced gene transcription remained unchanged, while in vitro proliferative lifespan was significantly increased, with about 10 additional population doublings before reaching terminal growth arrest. However, differentiation capacity into adipogenic progeny was diminished and no osteogenic differentiation was detectable at 3% oxygen. In turn, MSC that had previously been cultured at 3% oxygen could subsequently be stimulated to successfully differentiate at 20% oxygen. These data support our preliminary finding that primary MSC are enriched at the surface of spongy bone. Low oxygen levels in this location provide a milieu that extends cellular lifespan and furthermore is instructive for the stemness of MSC allowing proliferation upon stimulation while suppressing differentiation.
Making and Using Antibodies (2013)

Antibodies protect us from a wide range of infectious diseases and cancers and have become an indispensable tool in science-both for conventional immune response research as well as other areas related to protein identification analysis. This second edition of Making and Using Antibodies: A Practical Handbook provides clear guidance on all aspects
Acetals as pH-Sensitive Linkages for Drug Delivery (2004)

pH-Sensitive linkages designed to undergo hydrolysis at mildly acidic pH can trigger the release of therapeutics selectively at targets such as tumor and inflammatory tissues and in the endosomes and lysosomes of cells. Acetals have the potential to be used as linkages for a range of alcohol functionalities, and, by altering their chemical structure, it is possible to tune their hydrolysis rate. The syntheses of four conjugates of model drug molecules with PEO using acetals of varying chemical structure are described herein. Primary and secondary alcohols, as well as syn-1,2-diols, were incorporated in the conjugates. The hydrolysis kinetics were investigated by HPLC, and the conjugates had half-lives ranging from less than 1 min to several days at pH 5.0, with slower hydrolysis at pH 7.4 in all cases. These acetal linkages are therefore promising for use in a variety of drug delivery applications ranging from polymer-drug conjugates to pH-sensitive micelles and nanoparticulate systems.
A nonnatural transcriptional coactivator (1997)

In eukaryotes, sequence-specific DNA-binding proteins activate gene expression by recruiting the transcriptional apparatus and chromatin remodeling proteins to the promoter through protein-protein contacts. In many instances, the connection between DNA-binding proteins and the transcriptional apparatus is established through the intermediacy of adapter proteins known as coactivators. Here we describe synthetic molecules with low molecular weight that act as transcriptional coactivators. We demonstrate that a completely nonnatural activation domain in one such molecule is capable of stimulating transcription in vitro and in vivo. The present strategy provides a means of gaining external control over gene activation through intervention using small molecules.
Fluid jet with variable thickness in the range 5-20 mu m (1994)

The production of a fluid jet with a thickness variable in the range of 5-20 mu m is described. In the investigated arrangement a liquid jet flowing out of a cylindrical nozzle hits a plexiglass plate near its edge and spreads forming a very thin sheet. The thickness can be easily varied by changing the angle between the nozzle and the plate. Using a dye solution in this set-up, a short-cavity dye laser of length 15 mu m has been constructed.
Treatment of BCL1 leukemia by transplantation of low density fractions of allogeneic bone marrow and spleen cells (1992)

C57BL/Ka bone marrow and spleen cells fractionated by density gradients were transplanted to lethally irradiated (800 rad) BALB/c recipients. Unfractionated bone marrow and spleen cell mixtures (1:1), or high density fractions of these cells induced acute lethal graft-vs-host disease (GVHD). In contrast, low and middle density fractions of bone marrow and spleen cell mixtures reconstituted the irradiated hosts, and the majority survived for at least 100 days. The latter cells contained sufficient hemopoietic cells for reconstitution, but were deficient in inducing GVHD. Examination of the T cell subsets in the low density fractions showed a reduction of typical alpha beta TCR+ CD4+ or CD8+ cells and little change in the proportion of alpha beta TCR+ CD4- CD8- cells. BALB/c mice injected with the BCL1 B cell leukemia/lymphoma were lethally irradiated and transplanted with unfractionated BALB/c or C57BL/Ka bone marrow and spleen mixtures or low density fractions of C57BL/Ka mixtures. All control unirradiated BALB/c mice given the BCL1 tumor cells died by day 55. Almost all BALB/c mice given the BCL1 tumor cells, irradiation, and injected with a syngeneic marrow and spleen mixture died by day 95. All of the latter recipients tested showed evidence of tumor relapse. Almost all BALB/c mice given BCL1 cells, irradiation, and a C57BL/Ka unfractionated marrow and spleen mixture died by day 40. The survival of BALB/c mice given BCL1 cells, irradiation, and a low density fraction of the C57BL/Ka mixture was markedly prolonged as compared to those recipients given unfractionated allogeneic or syngeneic mixtures. None of the low density fraction recipients tested showed evidence of tumor relapse. Similar results were obtained with leukemic C57BL/Ka x BALB/c F1 hybrid mice. Thus, the low density fraction fails to induce acute lethal GVHD, but retains graft-vs-leukemia activity.
Endometrial Cancer (2008)

This review summarizes the epidemiology, prevention, diagnosis and treatment, and prognosis of endometrial carcinoma. Although the incidence of disease has remained stable, the death rate has increased over 100% over the last two decades. Precursor lesions of complex hyperplasia with atypia are associated with an endometrial carcinoma in over 40% of cases. The percentage of obese women with endometrial cancer is increasing. The incidence of endometrial cancer in white women is twice the incidence in African-American women, but stage for stage, African-American women have a less favorable prognosis. Preoperative imaging cannot accurately assess lymph node involvement. Gross examination of depth of myometrial invasion does not have the sensitivity, specificity, and positive or negative predictive value to select women who can have lymphadenectomy safely omitted from the surgical procedure. In the absence of ideal noninvasive preoperative testing, surgical staging remains the most accurate method of determining the extent of disease. There has been an increase in surgical staging and a decrease in postoperative adjuvant pelvic radiation therapy over the past two decades. Women with a family history of hereditary nonpolyposis colorectal colon cancer are at increased risk for endometrial cancer. Conservative treatment to allow for childbearing is possible in select situations. Women with endometrial cancer should be managed by physicians experienced in the treatment of this disease.
Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency Syndrome (1984)

We studied the frequency with which unexplained oral candidiasis led to unequivocal acquired immunodeficiency syndrome (AIDS) in patients at risk. Twenty-two previously healthy adults with unexplained oral candidiasis, of whom the 19 tested had a reversed T4/T8 ratio and 20 had generalized lymphadenopathy, were compared with 20 similar patients with a reversed T4/T8 ratio and generalized lymphadenopathy who did not have oral candidiasis. All were intravenous-drug abusers, homosexual or bisexual men, or both. Thirteen of the 22 patients with oral candidiasis (59 per cent) acquired a major opportunistic infection or Kaposi's sarcoma at a median of three months (range, 1 to 23) as compared with none of 20 patients with generalized lymphadenopathy and immunodeficiency but without candidiasis who were followed for a median of 12 months (range, 5 to 21) (P less than 0.001). AIDS developed in 12 of 15 patients with candidiasis and T4/T8 ratios less than or equal to 0.51, as compared with none of four with ratios equal to or greater than 0.60 (P less than 0.01). We conclude that in patients at high risk for AIDS, the presence of unexplained oral candidiasis predicts the development of serious opportunistic infections more than 50 per cent of the time. Whether the remainder will have AIDS is not yet known.
Precision modeling of the mask–substrate evolution during ion etching (1988)

A precise and detailed study of mask–substrate system evolution under spatially uniform ion flux erosion conditions is presented. Theoretical, geometrical, and computational approaches for homogeneous, heterogeneous, and time‐dependent systems are briefly discussed. It is shown that the model is general and valid for any mask–substrate system. An example is given which shows how the same model can be used to optimize a bilayer resist system.
Peroxynitrite modification of low‐density lipoprotein leads to recognition by the macrophage scavenger receptor (1993)

Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of alpha-tocopherol to alpha-tocopherol quinone.
Estrogens in carcinoma of the prostate. Effects on enzymes and polypeptide hormones. (1978)

Patients with benign hyperplasia of the prostate and with anaplastic carcinoma have similar activities in their cells in staining for acid phosphatase. After therapy with estrogens the acid phosphatase is significantly inhibited, leucin amino peptidase and succinate dehydrogenase appear to be reactivated in the cells of anaplastic carcinoma. Serum TSH is decreased distinctly, serum levels of LH and prolactin are significantly elevated especially in patients with anaplastic carcinoma of the prostate in comparison to that of patients with treated benign hyperplasia.
Nuclear endo-exonuclease of Neurospora crassa. Evidence for a role in DNA repair. (1987)

The major nuclease activity in nuclei of mycelia of Neurospora crassa has been identified as that of endoexonuclease, an enzyme purified and characterized previously from mitochondria and vacuoles which acts endonucleolytically on single-stranded DNA and RNA and possesses highly processive exonuclease activity with double-stranded DNA. Cross-contamination from the other organelles was eliminated as a source of the activity. Endo-exonuclease of nucleoplasm, chromatin, and nuclear matrix showed 80-100% cross-reaction with antisera raised to purified extranuclear endoexonuclease and was also strongly inhibited by 20 microM aurin tricarboxylic acid. In addition, it yielded some of the same-sized polypeptides on activity gel analysis. Nuclei also contained immunochemically cross-reactive trypsin-activable endo-exonuclease activity, a form of enzyme that was shown previously to occur in high amounts in the cytosol and in a tightly bound form associated with the mitochondrial inner membrane. Pretreatment of wild-type mycelia for 1 h with 4-16 micrograms/ml the DNA-damaging agent, 4-nitroquinoline-1-oxide (4-NQO), which caused about 50-80% growth inhibition, resulted in a dose-dependent loss of up to 80% of inactive endo-exonuclease from nuclei. At low doses of 4-NQO, this was accompanied by increases in the level of active enzyme. Nuclei of the DNA repair-deficient uvs-3 mutant were found to contain only 12% of the active enzyme and about 32% of inactive enzyme as that in wild-type nuclei. Mycelial growth of this mutant was 10 times more sensitive to 4-NQO than the wild-type. At a dose which resulted in equivalent growth inhibition, 4-NQO had no effect on the level of active endo-exonuclease in uvs-3 nuclei and caused an increase (over 30%) in the level of inactive enzyme. These data are consistent with a role of endo-exonuclease in the repair of nuclear DNA.
Optical Design of Intraocular Lenses. III. On-Axis Performance in the Presence of Lens Displacement (1989)

The effect of intraocular lens shape on on-axis performance of model pseudophakic eyes was investigated, when lenses were displaced by tilting or decentration. Image quality criteria included an optimization procedure, spot diagrams, and the modulation transfer function (MTF). Displacement adversely affects image quality. With conventional lens shapes, the deterioration is either small or retinal image quality can be nearly restored to predisplacement levels by spectacle correction. Optimum lens shapes in the presence of decentration are close to being plano-convex, with the more curved surface facing the cornea. Based on the results of this and previous studies, it is suggested that preferred shapes of intraocular lenses range from this plano-convex form to equi-convex.
Respiratory Syncytial Virus Recombinant F Protein (Residues 255–278) Induces a Helper T Cell Type 1 Immune Response in Mice (2007)

We have developed and evaluated an immunodominant respiratory syncytial virus (RSV) F antigen in a mouse model. The antigenic region corresponding to amino acids 255-278 of the RSV F protein was cloned into a vector containing the ctxA(2)B gene of cholera toxin (CT). The recombinant protein was expressed in Escherichia coli and analyzed on sodium dodecyl sulfate-polyacrylamide gels. The purified protein was evaluated by immunoblot and ganglioside GM(1) enzyme-linked immunosorbent assay to confirm the expression of the RSV F protein and to correct association of the recombinant protein to form a holotoxin-like chimera, respectively. We hypothesized that genetic fusion of modified CT-based adjuvant with RSV F immunodominant epitopes (rRF-255) would induce protective humoral and cellular immune responses in mice. Intranasal immunization of mice with rRF-255 overall induced higher concentrations of anti-RSV F-specific antibodies in both serum and saliva as compared with mice immunized intranasally with RSV or phosphate-buffered saline (PBS). Antibody isotype analysis (IgA, IgG1, IgG2a, and IgG2b) was also performed. The predominant IgG2a antibody isotype response in combination with cytokine analysis of helper T cell type 1 (interferon-gamma, interleukin [IL]-2, IL-12 p70, and tumor necrosis factor-alpha) and helper T cell type 2 (IL-4 and IL-10) responses revealed that rRF-255 antigen induces a prominent helper T cell type 1 immune response in mice. The rRF-255 antigen also induced serum neutralizing antibodies in immunized mice. Analysis of RSV load in lungs showed that rRF-255 immunization provided significant protection compared with PBS control animals.
Raising of Mahogany (Swietenia Mahagoni L.) Seedlings to Combat Climate Change as Influenced by Organic Manures and Chemical Fertilizers (2021)

Effects of various organic manures on the growth, performance and biomass production of Mahogany seedlings, an experiment was carried out in the net house of the Department of Soil, Water and Environment, University of Dhaka. Nine types of manures, viz. Kazi, ACI, Payel, BGF-1, Mazim, SK, Supermill, Sebok, Sufola organic manures were used separately at the rate of 12 ton/ha. Another dose of NPK inorganic fertilizer was used at the rate of 5kg/ha N, 3 kg/ha P, 3 kg/ha K respectively. Height, leaf area, and fresh and dry weights of leaf varied significantly (p≤ 0.5) and increased with time. Maximum leaf number (41.33 no./plant) and branch (6.33 no./plant) was found in Payel compost but maximum N concentration (2%) in leaf was obtained in Sebok treatment. Highest plant height (48.33 cm), leaf area (204.766 cm2/plant), girth (3.067 cm/plant), fresh weight (37.79g/plant), dry weight (9.16 g/plant), and length of petiole (6.33 cm) were recorded in Supermill treatment at harvest. Results showed that the overall best growth performance of seedlings was achieved in Supermill compost. J. Biodivers. Conserv. Bioresour. Manag. 2020, 6(2): 19-26
Low-crosstalk 2 × 2 thermo-optic switch with silicon wire waveguides (2010)

We demonstrate a low-crosstalk 2 x 2 thermo-optic switch with silicon wire waveguides. The device is based on a 2 x 2 array of Mach-Zehnder interferometer (MZI) switches. Lowest crosstalk levels of -50 dB and -30 dB are obtained for 'bar' and 'cross' switching states, respectively. An intersection in the switch is important for low-crosstalk operation. The power consumption of one MZI element switch is 40 mW and the total power consumption of the device is at most 160 mW.
Effect of extreme amino acid starvation on the protein synthetic machinery of CHO cells (1978)

Abstract When CHO cells are incubated under conditions of extreme amino acid starvation, effected by withdrawal of an amino acid from the medium together with genetic or chemical interference with the activity of the corresponding aminoacyl‐tRNA synthetase, there is a rapid and profound decline in the functional capacity of the protein synthetic machinery. The effect was observed for all amino acids tested including leucine, asparagine, histidine, methionine and glutamine. This decline in protein synthetic potential appears to be due to a progressive permanent inactivation of the specific aminoacyl‐tRNA synthetase concerned, as shown by a decline in the amount of cellular, specific aminoacyl‐tRNA and a decline in the cell‐free enzyme activity, measured after reversal of the starvation conditions. When cells are left for more than several hours under these starvation conditions, they shrink in size, lose viability and eventually disintegrate, with anomalous rapidity. We suggest that the progressive loss of protein synthetic capacity of the cells is the prime cause of these subsequent events. If the starvation conditions are reversed before cell death, regeneration of the protein synthetic potential occurs rapidly but requires protein synthesis itself, implying the existence of strong control mechanisms for cellular aminoacyl‐tRNA synthetase activities.