gebhart/patrepeval huggingface dataset:
Immunosuppression to cardiac allografts and soluble antigens by anti-vascular cellular adhesion molecule-1 and anti-very late antigen-4 monoclonal antibodies. (1994)

Effective activation of T cells in immune responses depends on two signals, one from the CD3/TCR complex and another from accessory cell surface proteins. Very late Ag-4 (VLA-4) can exert a costimulatory function upon binding with vascular cellular adhesion molecule-1 (VCAM-1). We investigated the effects of mAbs against VCAM-1 and VLA-4 on cardiac allograft survival and humoral response to soluble Ags. BALB/c hearts were transplanted into C3H/He recipients. mAbs (100 micrograms/day) were administered i.p. for the first 6 days. Graft survival in mice treated with M/K-2 (anti-VCAM-1; median survival: 20 days, n = 6) and those treated with PS/2 (anti-VLA-4; 30 days, n = 6) was greater than that in control mice (8 days, n = 7). Eight of 18 mice treated with both M/K-2 and PS/2 accepted the grafts over 65 days, and five of them accepted the grafts over 100 days. Allografts treated with the two mAbs showed scattered infiltration of leukocytes without evidence of active rejection at 65 days. Mice with long-surviving cardiac grafts were challenged with skin grafts from donor and third-party (C57BL/6) strains. Survival of the donor-type skin was significantly greater than that of the third-party skin. One mouse specifically accepted the donor-type skin indefinitely (> 150 days). FACS analysis of splenocytes at 55 days after transplantation showed complete recovery of VLA-4 expression from a down-regulation observed at day 7. In addition, mice immunized with heat-aggregated human gamma-globulin did not produce specific Ab, even after boost immunization, if PS/2 was administered at the time of the first immunization. This unresponsiveness to xenogeneic protein lasted for more than 50 days. These results indicate that in vivo administration of anti-VCAM-1 and anti-VLA-4 mAbs induces specific immunosuppression to cardiac allografts and soluble Ags.
New Financial Instruments for Hedge Changes in Volatility (1989)

(1989). New Financial Instruments for Hedge Changes in Volatility. Financial Analysts Journal: Vol. 45, No. 4, pp. 61-65.
Modulation (2002)

This chapter deals with the central issue of modulation between two given tonalities. It involves explicit models of tonalities, of cadences and—even more crucial—of the transition process from one tonality to its successor. The present model involves the analogy to elementary particle physics: Modulation is viewed as a ‘force interaction’ between two ‘tonality particles’ which is mediated by a ’modulation quantum’. The model allows for a complete calculation of fundamental degrees of modulation in congruence with A. Schönbergs harmony [478]. The model is realized for diatonic tonalities in 12-tempered and just tuning. It has been extended to all 7-element scales in 12-tempered tuning and to a number of scales in just tuning. The 12-tempered extension reveals a privileged position of the diatonic scale with regard to this modulation theory. We conclude the chapter with a discussion of the basic role of modulation models and their application to optimize harmonic paths in the sense of section 27.2.
Charge storage behavior of isotropic and biaxially‐oriented polypropylene films containing α‐ and β‐nucleating agents (2005)

Abstract A study on the influence of the crystal modification (α and β) of isotactic polypropylene (i‐PP) films on the resulting electret properties is presented. Two commercial nucleating agents, sodium 2,2′‐methylene‐bis(4,6‐di‐ tert ‐butylphenyl)‐phosphate (NA11) and N,N′‐dicyclo‐hexyl‐2,6‐naphthalene‐dicarbox‐amide (NU100), were employed in this investigation. Isothermal charge decay was measured at 90°C. In hot pressed isotropic polypropylene films, no significant differences in the charge storage properties were observed for α‐ and β‐nucleated specimens. In addition, the article presents the influence of the nucleating agents at different concentrations on the PP‐film morphology of biaxially stretched films with respect to electret features. It was possible to prepare elongated cavities with the virtually insoluble NA11 additive during stretching, even at concentrations below 0.3 wt %. These films displayed slightly improved electret properties in comparison to stretched neat PP films due to generated cavities acting as barriers for the drift of charges. Various draw ratios were also studied for i‐PP films with 0.15 wt % NA11. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 650–658, 2006
Pre-Shared Key Cipher Suites for TLS with SHA-256/384 and AES Galois Counter Mode (2009)

RFC 4279 and RFC 4785 describe pre-shared key cipher suites for
Transport Layer Security (TLS). However, all those cipher suites use
SHA-1 as their MAC algorithm. This document describes a set of pre-
shared key cipher suites for TLS which uses stronger digest algorithms
(i.e., SHA-256 or SHA-384) and another set which uses the Advanced
Encryption Standard (AES) in Galois Counter Mode (GCM).
Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4. (2007)

The generated Stgd3-knockin mice are a genetic model of human STGD3 and reproduce features of the human disease: accumulation of lipofuscin and reduced visual functions. Homozygous Stgd3 mice showed a complete absence of acylceramides from the epidermis. Their absence suggests a role for Elovl4 in acylceramide synthesis, and in particular, a role in the synthesis of the unique very long chain C30-C40 fatty acids present in skin acylceramides.
Etanercept versus methotrexate in patients with early rheumatoid arthritis: Two‐year radiographic and clinical outcomes (2002)

Etanercept as monotherapy was safe and was superior to MTX in reducing disease activity, arresting structural damage, and decreasing disability over 2 years in patients with early, aggressive RA.
Chemical stability of pharmaceuticals (1979)

Chemical stability of pharmaceuticals , Chemical stability of pharmaceuticals , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Domain Adaptation via Pseudo In-Domain Data Selection (2011)

We explore efficient domain adaptation for the task of statistical machine translation based on extracting sentences from a large generaldomain parallel corpus that are most relevant to the target domain. These sentences may be selected with simple cross-entropy based methods, of which we present three. As these sentences are not themselves identical to the in-domain data, we call them pseudo in-domain subcorpora. These subcorpora – 1 % the size of the original – can then used to train small domain-adapted Statistical Machine Translation (SMT) systems which outperform systems trained on the entire corpus. Performance is further improved when we use these domain-adapted models in combination with a true in-domain model. The results show that more training data is not always better, and that best results are attained via proper domain-relevant data selection, as well as combining in- and general-domain systems during decoding. 1
Superior Storage Performance of a Si@SiO<sub><i>x</i></sub>/C Nanocomposite as Anode Material for Lithium‐Ion Batteries (2008)

Full charge ahead: Hydrothermal carbonization of glucose in the presence of Si nanoparticles yields a [email protected]x/C nanocomposite that has high reversible lithium-storage capacity, excellent cycling performance, and high rate capability. This material shows promise as an anode material in lithium-ion batteries. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704287_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Human papillomavirus vaccines for the treatment of cervical cancer (2006)

Human papillomavirus (HPV) infection is a major cause of cervical cancer, the second most common cancer in women worldwide. Currently, a HPV L1-based virus-like particle has been approved as a prophylactic vaccine against HPV infection, which will probably lead to a reduction in cervical cancer incidence within a few decades. Therapeutic vaccines, however, are expected to have an impact on cervical cancer or its precursor lesions, by taking advantage of the fact that the regulatory proteins (E6 and E7) of HPV are expressed constantly in HPV-associated cervical cancer cells. Vaccine types targeting these regulatory proteins include the recombinant protein and DNA vaccines, peptide vaccines, dendritic-cell vaccines, and viral and bacterial vector deliveries of vaccines, and these may provide an opportunity to control cervical cancer. Further approaches incorporating these vaccine types with either conventional therapy modalities or the modulation of CD4(+) regulatory T cells appear to be more promising in achieving increased therapeutic efficacy. In this review, we summarize current and future therapeutic vaccine strategies against HPV-associated malignancies at the animal and clinical levels.
DESIGNING QUIETER HYDRAULIC SYSTEMSSOME RECENT DEVELOPMENTS AND CONTRIBUTIONS (1999)

This paper reviews the considerable progress that has been made over the last 25 years in the understanding of noise inhydraulic systems. Sources of fluid borne noise, structure borne noise and the resultant airborne are discussed in detailand methods of measuring, analysing and predicting behaviour are presented. This leads on to a discussion ofcomponent and system design issues. The paper concludes by identifying areas where further work is required.
Disintegration Propensity of Tablets Evaluated by Means of Disintegrating Force Kinetics (2000)

The aim of this work was to measure the disintegrating force concomitantly with tablet disintegration, in order to evaluate the disintegration propensity of tablets. Disintegration and dissolution were measured on tablets containing two poorly soluble drugs (diclofenac sodium or ketoprofen), including different percentages of two disintegrants (Explotab or Ac-Di-Sol). Because of the experimental setup, the disintegrating force measured was the result of the force generated by disintegrant swelling and dissipated by tablet disintegration. The disintegrating force versus time curves had shapes ranging from a skewed distribution curve to a bell-shaped curve, depending on slow or rapid disintegration of tablets, respectively. Interestingly, the shape of the resulting curves was very sensitive to the composition of the tablet. When the disintegrant in the formula was increased, the force-time curve approached the bell-like shape. The disintegration propensity of the tablet can be evaluated by the disintegrating force development during disintegration. The disintegration improvement of the formula can be predicted. The disintegrating force curve allows for the clear identification of the optimal percentage of disintegrant to be used.
Overlapping Community Detection by Collective Friendship Group Inference (2010)

There has been considerable interest in improving the capability to identify communities within large collections of social networking data. However, many of the existing algorithms will compartment an actor (node) into a single group, ignoring the fact that in real-world situations people tend to belong concurrently to multiple groups. Our work focuses on the ability to find overlapping communities by aggregating the community perspectives of friendship groups, derived from egonets. We will demonstrate that our algorithm not only finds overlapping communities, but additionally helps identify key members, which bind communities together. Additionally, we will highlight the parallel feature of the algorithm as a means of improving runtime performance.
The effect of gamma irradiation on the enzymatic degradation of polyglycolic acid absorbable sutures (1983)

The purpose of the study was to examine the effect of gamma irradiation on the enzymatic as well as the in vivo degradation of polyglycolic acid sutures. The sutures of size 2-0 were irradiated at dosage levels of 0-20 mrad. The three enzymes chosen for this study were esterase, alpha-chymotrypsin, and trypsin. The irradiated sutures were both immersed in the enzyme solutions; their corresponding buffer controls, and implanted in inbred black-and-white hooded hister rats (Liverpool strain). The degradation of PGA sutures was determined mechanically. Among the three enzymes studied, esterase showed the highest enzymatic effect on the degradation of the unirradiated and irradiated PGA sutures. Trypsin's effect on PGA sutures was not observed until 20 mrad. The findings of trypsin demonstrated the hypothesis that synthetic high molecular weight polymers, which are initially resistant to enzymatic degradation, could become prone to enzymatic attack after altering their physical and chemical structures. Implanted PGA sutures maintained a similar or slightly higher mean tensile breaking strength in in vivo degradation compared to in vitro degradation (0.1M tris buffer of pH = 7.5); these degradation profiles suggest that PGA does not display similar behavior in in vivo and in vitro degradations. The magnitude of dissimilarity depends on the radiation dosage and on the duration of degradation, and is speculated to be attributable to the specific action of enzymes with respect to the configuration and chemical structure of the PGA sutures.
Active Specific Immunotherapy Against Adenocarcinomas (1994)

(1994). Active Specific Immunotherapy Against Adenocarcinomas. Cancer Investigation: Vol. 12, No. 1, pp. 46-56.
Extraction of Dissolved Methane in Brines by CO2 Injection: Implication for CO2 Sequestration (2009)

Abstract The solubility of CO2 in underground saline formations is considered to offer significant long-term storage capability to effectively sequester large amounts of anthropogenic CO2. Unlike EOR, geosequestration relies on longer time scales and involves significantly greater volumes of CO2. Many geosequestration studies assume that the initial brine state is one containing no dissolved hydrocarbons and therefore apply simplistic two component solubility models starting from a zero dissolved gas state. Many brine formations near hydrocarbons however tend to be close to saturation by methane. The introduction of excess CO2 in such systems results in an extraction of the methane into the CO2 rich phase which in turn, has implications for monitoring of any sequestration project and offers the possibly additional methane mobilization and recovery.
Simulating Circadian Light: Multi-Dimensional Illuminance Analysis (2017)

The effects of building design on human circadian rhythms have been linked to health, behavior, and performance outcomes. Limited options, however, are available for predicting circadian stimuli during the design process, other than via quantification of a single variable known as melanopic illuminance. Several additional circadian illuminance quantities (including rhodopic-, cyanopic-, chloropic-, and erythropic-lux) have not, to date, been utilized in simulating circadian exposure. We demonstrate how daylight, spatial, and material choices may alter the contribution of five currently-known photoreceptor channels to regulating circadian rhythms. This novel 3D rendering system will also support future circadian research and applied solutions.
Trichorzins HA and MA, Antibiotic Peptides from Trichoderma harzianum. II. Sequence Determination. (1995)

A series of 18-residue antibiotic-antifungal peptides, trichorzins HA and MA, were isolated from Trichoderma harzianum strains exhibiting antagonistic properties against phytopathogenic fungi. The sequences of the nine major pure peptides isolated by HPLC were determined by positive ion FAB-MS data and two-dimensional NMR measurements, including COSY, HOHAHA, ROESY and 1H-13C LRCOSY experiments.
Private record matching using differential privacy (2010)

Private matching between datasets owned by distinct parties is a challenging problem with several applications. Private matching allows two parties to identify the records that are close to each other according to some distance functions, such that no additional information other than the join result is disclosed to any party. Private matching can be solved securely and accurately using secure multi-party computation (SMC) techniques, but such an approach is prohibitively expensive in practice. Previous work proposed the release of sanitized versions of the sensitive datasets which allows blocking, i.e., filtering out sub-sets of records that cannot be part of the join result. This way, SMC is applied only to a small fraction of record pairs, reducing the matching cost to acceptable levels. The blocking step is essential for the privacy, accuracy and efficiency of matching. However, the state-of-the-art focuses on sanitization based on k-anonymity, which does not provide sufficient privacy. We propose an alternative design centered on differential privacy, a novel paradigm that provides strong privacy guarantees. The realization of the new model presents difficult challenges, such as the evaluation of distance-based matching conditions with the help of only a statistical queries interface. Specialized versions of data indexing structures (e.g., kd-trees) also need to be devised, in order to comply with differential privacy. Experiments conducted on the real-world Census-income dataset show that, although our methods provide strong privacy, their effectiveness in reducing matching cost is not far from that of k-anonymity based counterparts.
Patterning Self-Assembled Monolayers: Applications in Materials Science (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPatterning Self-Assembled Monolayers: Applications in Materials ScienceAmit Kumar, Hans A. Biebuyck, and George M. WhitesidesCite this: Langmuir 1994, 10, 5, 1498–1511Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/la00017a030https://doi.org/10.1021/la00017a030research-articleACS PublicationsRequest reuse permissionsArticle Views7119Altmetric-Citations1008LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
THE ELASTICITY OF THE CRANIAL BLOOD POOL. (1964)

It is generally recognized that the cranial cavity is quite inelastic, and any increase in volume of its contents quickly results in an increase in intracranial pressure. The incompressibility of the cranial contents has been expressed in the Monro-Kellie Doctrine. One can easily increase the volume of intracranial contents by occluding the venous drainage from the head. The arterial supply to the head continues until the venous pressure rises sufficiently to overcome the obstruction. The Queckenstedt maneuver, familiar to all clinicians, is the commonly practiced technique for elevating intracranial pressure and consists of bilateral jugular compression with resultant elevation of spinal fluid pressure as measured in the lumbar subarachnoid space. In general, this is used to test the patency of the sub arachnoid space between the cranial cavity and the lumbar subarachnoid space. Several studies on the effect of increased jugular pressure or intracranial pres sure on cerebral hemodynamics have been reported. Many investigators believe that moderate elevation of venous pressure would be unlikely to significantly de creasecerebralbloodflow(1).Moyer etal(2)reportedthatcerebralbloodflow was not affected by obstructing the venous outflow of blood from the brain. During the course of some studies of cerebral circulation (3, 4), we had oc casion to measure the cranial blood pool volume after the introduction into the circulating blood pool of Radioactive Iodinated Serum Albumin (RISA). With the application of measured pressure to the neck the cranial blood volume increases rapidly and plateaus at a new higher level. We have assessed three aspects of this phenomenon. 1. The relationship between the height of this final plateau value and the amount of pressure applied to the neck. 2. The pos sibility of applying this test as a dynamic study of symmetry of cranial venous drainage, which is quite different from individual to individual. 3. The interest ing possibility of applying this technique as a plethysmographic measurement of blood flow into the cranium.
Thermoacoustic Molecular Imaging of Small Animals (2003)

We have designed, constructed, and tested a thermoacoustic computed tomography (TCT) scanner for imaging optical absorption in small animals in three dimensions. The device utilizes pulsed laser irradiation (680-1064 nm) and a unique, 128-element transducer array. We quantified the isotropic spatial resolution of this scanner to be 0.35 mm. We describe a dual-wavelength subtraction technique for isolating optical dyes with TCT. Phantom experiments demonstrate that we can detect 5 fmol of a near-infrared dye (indocyanine green, ICG) in a 1-microL volume using dual-wavelength subtraction. Initial TCT imaging in phantoms and in two sacrificed mice suggests that three-dimensional, optical absorption patterns in small animals can be detected with an order of magnitude better spatial resolution and an order of magnitude better low-contrast detectability in small animals when compared to fluorescence imaging or diffusion optical tomography.