gebhart/patrepeval huggingface dataset:
Introduction (1992)

Introductions| December 03 2008 Introduction Subject Area: Endocrinology , Women's and Children's Health A. Eshkol A. Eshkol Ares Services S.A., Geneva, Switzerland Search for other works by this author on: This Site PubMed Google Scholar Hormone Research (1992) 37 (Suppl. 2): 1–3. https://doi.org/10.1159/000182367 Article history Published Online: December 03 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation A. Eshkol; Introduction. Hormone Research 1 February 1992; 37 (Suppl. 2): 1–3. https://doi.org/10.1159/000182367 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsHormone Research in Paediatrics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1992Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Détermination de la viscosité intrinsèque de solutions de polymères par une simple détermination de la viscosité (1962)

Abstract By studying the molecular weights of various solutions of cis ‐1,4‐polyisoprene the authors arrived at the formula \documentclass{article}\pagestyle{empty}\begin{document}$$\left[ \eta \right] = \sqrt {2/c} \sqrt {\eta _{sp} - {\rm l}n\eta } _{rel} $$\end{document} which allowed the calculation of the intrinsic viscosity of the polymer solutions by a single viscosity determination. The formula was verified for different systems of polymer–solvent and the values are in accord with those obtained by extrapolation. An operating concentration of about 0.2% is recommended.
Selective Translation and Degradation of Heat-ShockMessenger RNAs in Drosophila (1990)

The rapid and dramatic induction of heat-shock proteins is accomplished by regulatory mechanisms acting at many different levels. Here we review current knowledge of two cytoplasmic mechanisms employed during the response in the fruit fly Drosophila melanogaster. (1) Heat-shock messages are translated with high efficiency during heat shock while most normal cellular messages are inactive. Sequences in the 5'-untranslated leader of heat shock mRNAs govern their preferential translation. (2) The messages for heat-shock proteins are unstable at normal temperatures. During heat shock, however, they are very stable and accumulate in large numbers. Sequences in their 3'-untranslated regions play a major role in determining their stability.
PHOSPHORIC ACID ESTER DERIVATIVES OF CHOLINE. BASIS FOR THE PHYSIOLOGICAL ACTIVITY OF -ONIUM COMPOUNDS. VIII<sup>1</sup> (1929)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPHOSPHORIC ACID ESTER DERIVATIVES OF CHOLINE. BASIS FOR THE PHYSIOLOGICAL ACTIVITY OF -ONIUM COMPOUNDS. VIII1R. R. Renshaw and C. Y. HopkinsCite this: J. Am. Chem. Soc. 1929, 51, 3, 953–954Publication Date (Print):March 1, 1929Publication History Published online1 May 2002Published inissue 1 March 1929https://pubs.acs.org/doi/10.1021/ja01378a047https://doi.org/10.1021/ja01378a047research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chronic pain assessment using heat beam dolorimetry (1987)

The heat beam dolorimeter (HBD) was developed to evaluate cutaneous pain thresholds in humans. In the present study, the hypothesis that a patient's underlying pain status affects his pain tolerance to an incident HBD stimulus was tested. Twenty-seven chronic pain patients with a variety of clinical problems unresponsive to conventional algological therapy were scheduled for neurosurgical procedures. These patients were evaluated pre- and postoperatively by the HBD procedure. On initial testing, drug-free pain patients showed significantly higher pain tolerance thresholds than normal volunteers (P < 0.02, Mann-Whitney U test). Postoperatively, incident pain tolerance thresholds in the HBD test were reducedfrom pre-surgical levels in these patients and were indistinguishable from the second evaluation latencies of volunteers (P > 0.05). Twenty-four of the 27 patients reported significant pain relief following surgery. Our results show that, in chronic pain patients, endogenous pain significantly affected incident pain perception in the HBD test when compared with the responses of normal pain-free volunteers. Consequently, HBD may be useful in objectively assessing chronic pain and its relief by neurosurgical procedures.
Implications of Tumor Growth Rate for the Natural History of Lung Cancer (1984)

The growth rate of lung cancer may be described by an exponential model in which the volume doubling time, or growth rate, is constant. The doubling time may vary from case to case by an order of magnitude so it is probably the most important factor in the natural history of the disease. While some aspects are uncertain, the exponential model seems to be reasonably valid because it is coherent with what we already know about the course of the disease. It helps explain the long interval between onset of carcinogen exposure and clinical manifestation, the reversibility of risk after cessation of smoking, the results of periodic roentgenographic screening, and the variability of prognosis. As a result, the exponential model has certain medicolegal implications.
First Use of Model Predictive Control in Outpatient Wearable Artificial Pancreas (2014)

This outpatient study confirms inpatient evidence of suitability of MPC-based strategies for AP. These encouraging results pave the way to randomized crossover outpatient studies.
NRF-1 is the major transcription factor regulating the expression of the human <i>TOMM34</i> gene (2008)

The human TOMM34 gene encodes a cytosolic protein with chaperone-like activity that helps import some preproteins to the mitochondria by keeping them in an unfolded, import-compatible state. TOMM34 was found to be upregulated frequently in colorectal tumors, suggesting that it also has a role in the growth of cancer cells. In this context, TOMM34 is a potential target for novel anticancer drugs, and it might also be used in the diagnosis of colorectal cancer. Nuclear respiratory factors (NRFs) play an important role in governing the nuclear-mitochondrial interactions implicated in mitochondrial biogenesis. Our previous studies revealed that NRFs promote the expression of the major members of the mitochondrial transport machinery, TOMM70 and TOMM20. Here we report the existence of binding sites for NRF-1, Sp1, and NRF-2 in the 5' region of the human TOMM34 gene. We determined the effects of mutations at these sites on promoter activity in HeLa S3 and A204 cells, in conjunction with chromatin immunoprecipitation experiments, electrophoretic mobility shift assays, and in vivo methylation analysis of the promoter region. We conclude that NRF-1 is the main transcription factor regulating the expression of TOMM34. Sp1 interacts with NRF-1 to stimulate the promoter's full activity.
Effects of Cold Stimulation on the Harmonic Structure of the Blood Pressure and Photoplethysmography Waveforms (2011)

It was demonstrated that the application of mild CS significantly changes several harmonic-analysis indexes of the BPW and the PPG waveforms. By providing detailed information about the pulse transmission of each frequency component, harmonic analysis may improve the ability to detect arterial elastic properties induced by CS, other forms of external stimulation, or pathological factors. It may be pertinent to the development of medical devices for application in telemedicine.
Apparent equilibrium shifts and hot-spot formation for catalytic reactions induced by microwave dielectric heating (1999)

Microwave dielectric heating of the gas phase decomposition of H2S catalysed by metal sulfides on a γ-Al2O3 support results in significant apparent shifts in the equilibrium constant, which have been attributed to the development of hot-spots in the catalytic beds; X-ray diffraction and electron microscopy measurements have indicated the formation of hot-spots with dimensions of 90–1000 µm and which involve not only the active phase, but also the support.
Principal Component Analysis of Diffuse Near-Infrared Reflectance Data from Paper Currency (1989)

Product tampering and product counterfeiting are increasing the need for methods to quickly determine product authenticity. One of the concepts that we are investigating for the detection of counterfeit objects involves the use of pattern recognition techniques to analyze multivariant data acquired from properties intrinsic to the object. The near-infrared reflectance spectra of currency and other paper stock were used as a test system. The sample population consisted of authentic currency, circulated and uncirculated, and cotton and rag paper stock as stand-ins for counterfeit currency. Reflectance spectra were obtained from a spot that was essentially void of printing on both sides of the currency specimens. Although the reflectance spectra for all of the samples were very similar, principal component analysis separated the samples into distinct classes without there being any prior knowledge of their chemical or physical properties. Class separation was achieved even for currency bills that differed only in their past environment. Leave-One-Out procedures resulted in 100% correct classification of each member of the sample set. A K-Nearest-Neighbor test or a linear discriminate can be used to correctly classify unknown samples.
The Building of Galactic Disks: Insights from the Triangulum Spiral Galaxy Messier 33 (2006)

Abstract The Triangulum Spiral Galaxy Messier 33 offers unique insights into the building of a galactic disk. We identify spectacular arcs of intermediate age (0.6 Gyr − 2 Gyr) stars in the low-metallicity outer disk. The northern arc spans ~120 degrees in azimuth and up to 5 arcmin in width. The arcs are located 2-3 disk scale lengths from the galaxy centre (where 1 disk scale length is equivalent to 0.1 degrees in the V-band) and lie precisely where there is a warp in the HI profile of M33. Warps and infall are inextricably linked (Binney, 1992). We present spectroscopy of candidate stars in the outer northern arc, secured using the Keck I telescope in Hawaii. The target stars have estimated visual magnitudes as faint as V~ 25m. Absorption bands of CN are seen in all spectra reported in this review talk, confirming their carbon star status. Also presented are PAH emissivity radial profiles generated from IRAC observations of M33 using the Spitzer Space Telescope. A dramatic change of phase in the m = 2 Fourier component is detected at the domain of the arcs. M33 serves as an excellent example how the disks of spiral galaxies in our Universe are built: as dynamically open systems, growing from the inward, outward.
<b>Hard and Soft Acids and Bases</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHard and Soft Acids and BasesRalph G. PearsonCite this: J. Am. Chem. Soc. 1963, 85, 22, 3533–3539Publication Date (Print):November 1, 1963Publication History Published online1 May 2002Published inissue 1 November 1963https://pubs.acs.org/doi/10.1021/ja00905a001https://doi.org/10.1021/ja00905a001research-articleACS PublicationsRequest reuse permissionsArticle Views28682Altmetric-Citations7890LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Handbook of Applied Expert Systems (2019)

From the Publisher:
The Handbook of Applied Expert Systems is a landmark work dedicatedsolely to this rapidly advancing area of study. Edited by Jay Liebowitz, a professor, author, and consultant known around the world for his work in the field, this authoritative source covers the latest expert system technologies, applications, methodologies, and practices. The book features contributions from more than 40 of the world's foremost expert systems authorities in industry, government, and academia.
The Handbook is organized into two major sections. The first section explains expert systems technologies while the second section focuses on applied examples in a wide variety of industries. Key topics covered include fuzzy systems, genetic algorithm development, machine learning, knowledge representation, and much more.
Characterizing the effects of nonlinear amplifiers on linear modulation for digital portable radio communications (1990)

The design and performance of linear modulation techniques and RF power amplifiers are discussed. Various types of power amplifier are used in the comparison, using simulation, of out-of-band radiation and power efficiency. The designs focus on high-frequency silicon bipolar power amplifiers suitable for low-power portable radio applications. Two different 4-QAM (4-level quadrature amplitude modulation) schemes are compared. Power efficiency as high as 40% can be achieved using a dynamically biased amplifier operating near saturation. The effects of nonlinear distortions from power amplifiers on adjacent channel interference as well as bit and block error rate performance are also investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Multidrug resistance ABC transporters (2003)

Clinical multidrug resistance is caused by a group of integral membrane proteins that transport hydrophobic drugs and lipids across the cell membrane. One class of these permeases, known as multidrug resistance ATP binding cassette (ABC) transporters, translocate these molecules by coupling drug/lipid efflux with energy derived from the hydrolysis of ATP. In this review, we examine both the structures and conformational changes of multidrug resistance ABC transporters. Together with the available biochemical and structural evidence, we propose a general mechanism for hydrophobic substrate transport coupled to ATP hydrolysis.
Glycoproteins of herpes simplex virus type 2 as defined by monoclonal antibodies (1982)

We used monoclonal antibodies reacting with glycoproteins specified by herpes simplex virus type 2 (HSV-2) to characterize the individual antigens in terms of structure, processing, and kinetics of synthesis in BHK or Vero infected cells. Our results provided a direct demonstration of the structural identity of the gA and gB proteins of HSV-2 as well as confirmation of the existence of type-specific and type-common domains within the gD molecule. They also show that, with the exception of gC, processing of the viral glycoproteins differs to some extent in Vero and BHK infected cells, possibly as a result of different efficiency of glycosylation or different processing of underglycosylated and unglycosylated products in the two cell types. Finally, we showed that individual HSV-2 glycoproteins are synthesized at greatly different times during the infectious cycle, possibly in response to their different roles in virus replication and assembly.
Renewal of EBV-hybridoma method: Efficient generation of recombinant fully human neutralizing IgG antibodies specific for tetanus toxin by use of tetroma cells (2007)

We have generated tetroma cell lines by the fusion of newly developed parental 6JC5.2 cells with a human B cell line, which was transformed with Epstein-Barr virus (EBV) and enriched with antibody-forming cells that produce neutralizing antibodies to tetanus toxin (TT) by a limiting dilution method using IL-6. The resultant two tetroma cell lines stably produced different monoclonal antibodies (mAbs), TT1 (IgG1.lambda) and TT2 (IgG4.kappa) reactive with TT after three-times consecutive cell cloning. Although weak to almost nonexistent neutralizing activities against TT were detected in TT1 and TT2 mAbs, respectively, mixing of them resulted in a dramatic increase in the neutralizing activity and complete protection from the toxin was observed in vivo. Moreover, functional immunoglobulin (Ig) genes were cloned from at least 10 cells in the first cloning step of tetromas after the cell fusion. None of the endogenous Ig genes, derived from the parental cell that hinders functional Ig gene cloning, was amplified. In addition, the EBV genome derived from the B cells was eliminated from the antibody producing tetroma lines. This classical but revised EBV-hybridoma method using fusion partner 6JC5.2 may become one alternative method for production of fully human antibodies useful for prevention and treatment of infectious diseases and cancer.
Five different enzymatic activities are associated with the multienzyme complex of fatty acid oxidation from Escherichia coli (1979)

The purified multienzyme complex of fatty acid oxidation from Escherichia coli was found to possess 3-hydroxyacyl-coenzyme A (CoA) epimerase and cis-delta3-trans-delta2-enoyl-CoA isomerase activities in addition to the previously identified enoyl-CoA hydratase, L-3-hydroxyacyl-CoA dehydrogenase, and 3-ketoactyl-CoA thiolase activities. Evidence is presented in support of the proposed association of all five enzyme activities with one protein which apparently is composed of two types of subunits and which can exist in several aggregated forms. The five component enzymes of the complex were rapidly inactivated by tris(hydroxymethyl)aminomethane, whereas they remained active in the presence of potassium phosphate.
FINESSE: a financial information spreadsheet (2002)

We outline a spreadsheet-based system for visualization of real-time financial information. Our system permits the user to define arithmetic and presentation relationships amongst the various cells of the spreadsheet. The cells contain primitives that can be numbers, text, images, functions and graphics. Presenting financial information in this format allows its intended clients, the financial analysts, to work in the familiar environment of a spreadsheet and allows them the flexibility afforded by the powerful interface of the spreadsheet paradigm. In addition, our system permits real-time visualization of the financial data stream allowing its user to visually trade the changing market trends in two and three dimensions.
Conformational Control of Integrin‐Subtype Selectivity in <i>iso</i>DGR Peptide Motifs: A Biological Switch (2010)

The rearrangement of asparagine to isoaspartate (isoD) is responsible for the deactivation of many functional proteins. However, the isoDGR motif, which is optimally presented as a conformationally controlled cyclic pentapeptide, binds selectively to α5β1 integrin (see the docking model) with an affinity comparable to that of the peptidic antitumor agent Cilengitide. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Studies on the virus of Venezuelan equine encephalomyelitis. II. Modification by specific immune serum of response of central nervous system of mice. (1961)

Administration of VEE antiserum to mice in which infection of the central nervous system with the Trinidad strain of VEE virus had already been established resulted in early appearance of an inflammatory response in brain tissue. Perivascular cuffing, glial proliferation and lymphocytic infiltration into the meninges were manifest in the majority of such animals by the 3rd day after infection. At a comparable time, brains of mice simultaneously infected with VEE virus, but subsequently receiving identical amounts of serum devoid of VEE antibody, showed no histologic changes or only occasional minimal perivascular cuffing with or without a slight focal increase in glial cells. The effect was attributed to interaction between VEE viral antigen and antibody.