gebhart/patrepeval huggingface dataset:
Antimalarials. II. .alpha.-(2-Piperidyl)- and .alpha.-(2-pyridyl)-2-trifluoromethyl-4-quinolinemethanols (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntimalarials. II. .alpha.-(2-Piperidyl)- and .alpha.-(2-pyridyl)-2-trifluoromethyl-4-quinolinemethanolsRoger M. Pinder and Alfred BurgerCite this: J. Med. Chem. 1968, 11, 2, 267–269Publication Date (Print):March 1, 1968Publication History Published online1 May 2002Published inissue 1 March 1968https://pubs.acs.org/doi/10.1021/jm00308a017https://doi.org/10.1021/jm00308a017research-articleACS PublicationsRequest reuse permissionsArticle Views440Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Hydrostatic Pressure on Gases Dissolved in Water (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of Hydrostatic Pressure on Gases Dissolved in WaterT. Enns, P. F. Scholander, and E. D. BradstreetCite this: J. Phys. Chem. 1965, 69, 2, 389–391Publication Date (Print):February 1, 1965Publication History Published online1 May 2002Published inissue 1 February 1965https://pubs.acs.org/doi/10.1021/j100886a005https://doi.org/10.1021/j100886a005research-articleACS PublicationsRequest reuse permissionsArticle Views1134Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High‐Resolution Structure of the Oncocin‐DnaK Complex (2011)

Countering MDR pathogens: The proline-rich designer peptide oncocin is highly active against a number of antibiotic-resistant, Gram-negative pathogens. Here we deduce residues critical to its activity and the crystal structure of an oncocin–DnaK complex from a positional Ala scan. New lead compounds were highly resistant against serum and E. coli proteases. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Efficient production of silicon-on-insulator films by co-implantation of He+ with H+ (1998)

We have investigated the process of thin film separation by gas ion implantation and wafer bonding, as well as the more basic phenomenon of blistering, on which the technique is based. We show that when H and He gas implants are combined they produce a synergistic effect which enables thin-film separation at a much lower total implantation dose than that required for either H or He alone. By varying the H and He implantation doses we have been able to isolate the physical and chemical contributions of the gases to the blistering processes. We find that the essential role of H is to interact chemically with the implantation damage and create H-stabilized platelet-like defects, or microvoids. The efficiency of H in this action is linked to its effective lowering of the silicon internal surface energy. The second key component of the process is physical; it consists of diffusion of gas into the microvoids and gas expansion during annealing, which drives growth and the eventual intersection of the microvoids to form two continuous separable surfaces. He is more efficient than H for this process since He does not become chemically trapped at broken bonds and thus segregates into microvoids more readily. In particular, we have demonstrated that a 1×1016 cm−2 He dose in combination with a 7.5×1015 cm−2 H dose are sufficient to shear and transfer a thin silicon film onto a handle wafer after bonding the two wafers together.
Impairment of Acid-Neutralizing Capacity and Lesion Formation in the Rat Duodenum during Hemorrhagic Shock: Comparative Study with Indomethacin (1987)

The effects of hemorrhagic shock (HE) on duodenal pH, acid-neutralizing capacity and mucosal tolerance to acid were investigated in anesthetized rats, and they were compared with those of indomethacin. HE was performed by bleeding from the carotid artery to reduce arterial blood pressure to about 55 mmHg (3 ml of bleeding per 200 g of body weight), and indomethacin was given s.c. in a dose of 5 mg/kg. Duodenal pH was determined in the outflow from the proximal duodenum (1.7 cm) which was perfused with 10(-4) M HCl, and acid-neutralizing capacity was measured by back-titration of the perfusate to pH 4.0 with 10 mM HCl. Under these conditions, duodenal pH was kept at around 6.0 as the result of neutralization in the loop (approximately 8 microEq/hr). Both HE and indomethacin significantly decreased the pH and acid-neutralizing capacity. Administration of 16,16-dimethyl prostaglandin E2 (16-dmPGE2: 30 micrograms/kg, s.c.) significantly increased both pH and acid-neutralizing capacity in normal and indomethacin-treated rats, but failed to affect these parameters in rats under HE conditions. When the duodenal loop was perfused with 50 mM HCl for 1.5 hr, both HE and indomethacin induced extensive damage in the mucosa. Pretreatment with 16-dmPGE2 significantly reduced the formation of duodenal lesions induced by indomethacin but not by HE. These results suggest that HE as well as indomethacin impaired duodenal acid-neutralizing capacity to reduce the tolerance to acid of the mucosa. The deleterious effects of HE on the mucosa may be mainly due to a decreased mucosal blood flow, but not due to a deficiency of endogenous prostaglandins.
Activity and Gait Recognition with Time-Delay Embeddings (2010)

Activity recognition based on data from mobile wearable devices is becoming an important application area for machine learning. We propose a novel approach based on a combination of feature extraction using time-delay embedding and supervised learning. The computational requirements are considerably lower than existing approaches, so the processing can be done in real time on a low-powered portable device such as a mobile phone. We evaluate the performance of our algorithm on a large, noisy data set comprising over 50 hours of data from six different subjects, including activities such as running and walking up or down stairs. We also demonstrate the ability of the system to accurately classify an individual from a set of 25 people, based only on the characteristics of their walking gait. The system requires very little parameter tuning, and can be trained with small amounts of data.
On Economic Analysis of International Law (2009)

The economic analysis of international law is the new development of international law theories in last decade. Based on existing references, this thesis intents to promote application of economic analysis of international law in China with pluralistic ways of research (for examples, political, legal and economic) in order to understand the contemporary issues of international law and to have new ideas. The part I is a brief comparison between domestic and international laws from economic perspective, and then a description of applicable economic analysis for international law with an emphasis of its theoretical and practical significances. The part II is focused on Coase’s Law & Economics as the basis of economic analysis of international law. The part III to V provide with a few examples of economic analysis of international laws, i.e. law of international economic organization, international environmental law and international humanitarian law. The conclusion is given finally. Key words: theory of international law, economic analysis, law of international economic organization, international environmental law and international humanitarian law Resume: L’analyse economique de la loi internationale est le nouveau developpement des theories de la loi internationale dans la derniere decennie. Base sur des references existantes, cette these tente de promouvoir l’application de l’analyse economique de la loi internaionale en Chine avec des methodes de recherche pluralistes(par exemple, politique, legale et economique) afin de comprendre les problematiques contemporains de la loi internationale et de s’en faire de nouvelles idees. La partie I procede a une comparaison breve entre les lois domestiques et internationales sous l’angle economique et a une description des analyses economiques applicables aux lois internationales en mettant l’accent sur leurs significations theoriques et pratiques. La partie II se concentre sur la Loi de Coase&Economie qui sert de base d’analyse. De la partie III a la partie V, on trouve des exemples de l’analyse economique des lois internationals, par exemple, la loi internationale de l’organisation economique , la loi international de l’environnement et la loi internationale humaniste. Enfin, la conclusion est degagee. Mots-Cles: theorie de la loi internationale, analyse economique, loi internationale de l’organisation economique, loi internationale de l’environnement et loi internationale humaniste
An Integrated Binary Correlator Module (1982)

A correlator module using the Pseudo Random Comparison (PRC) algorithm has been designed and fabricated in a standard 8 ?m PMOS process. It demonstrated the validity of the principle and the feasibility of a low cost integrated correlator or RMS meter based on that principle. The chip runs at frequenties up to 2 MHz, dissipates 90 mW and its size is 2.4mm2
Shape-Persistent Molecular Architectures of Nanoscale Dimension (1997)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTShape-Persistent Molecular Architectures of Nanoscale DimensionJeffrey S. MooreView Author Information Departments of Chemistry and Materials Science & Engineering and The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois 61801 Cite this: Acc. Chem. Res. 1997, 30, 10, 402–413Publication Date (Web):October 14, 1997Publication History Received23 April 1997Published online14 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/ar950232ghttps://doi.org/10.1021/ar950232gresearch-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views2999Altmetric-Citations579LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Dendrons,Macrocycles,Monomers,Oligomers,Supramolecular chemistry Get e-Alerts
Evaluation of Likelihood Ratios for Complex Genetic Models (1991)

Although methods for computing likelihoods for simple genetic models on large and complex pedigrees have been known for some time, and although methods for evaluating likelihoods for complex genetic models on small pedigrees have likewise been well known, likelihood evaluation for complex models given data on extended pedigrees has remained an intractable problem. The Gibbs sampler provides a method of Monte Carlo evaluation of likelihood ratios for complex models on extended and/or complex pedigrees. With increasing computer speeds, this approach provides a tractable and efficient approach to many such likelihood evaluation problems in linkage and segregation analysis. In this paper, however, the authors restrict attention to two basic building-blocks of the overall process. The first is the sequential computation of Gaussian likelihoods for multiple random-effects models on extended pedigrees. The second is the use of this in the Monte Carlo evaluation of likelihoods for the classical mixed model of segregation analysis. The implementation of the Gibbs sampler on pedigrees that permits this Monte Carlo evaluation is detailed. An example is then presented, and finally, in the context of this same example, it is also shown how linkage analysis for a quantitative trait falls within this same framework.
High Cerebrospinal Fluid Tau and Low Amyloid β42 Levels in the Clinical Diagnosis of Alzheimer Disease and Relation to Apolipoprotein E Genotype (1998)

Levels of CSF Abeta42 decrease and levels of CSF tau increase in AD. Apolipoprotein E epsilon4 had a dose-dependent relationship with CSF levels of Abeta42, but not tau. Other covariates influenced CSF markers minimally. Combined analysis of CSF Abeta42 and tau levels discriminated patients with AD, including patients with mild dementia, from the NC group, supporting use of these proteins to identify AD and to distinguish early AD from aging. In subjects in the ND group with an AD CSF profile, autopsy follow-up will be required to decide whether CSF results are false positive, or whether AD is a primary or concomitant cause of dementia.
Renal Artery and Vein Injury Following Blunt Trauma (1975)

Blunt injuries of the renal vascular pedicle occur infrequently. The experience with fourteen cases of blunt renal vascular trauma is presented. Most patients were injured in motor vehicle accidents. The diagnosis was made immediately after admission in 6 patients, delayed in 5, and at autopsy in 3. Most patients presented with gross or microscopic hematuria. The diagnosis of renal vascular injury was suggested by IVP in most instances. Surgical management was used in the 6 patients in whom the immediate diagnosis of renal pedicle injury was made; primary vascular repair was carried out in 4 patients and nephrectomy in two. Conservative management was used in 4 of the 5 patients with delayed diagnosis, and nephrectomy was required in the fifth. Three patients received no treatment as two were dead on arrival and one die during laparotomy. Seven patients died (50%). One of the 7 survivors has a functioning kidney following repair of a renal vein laceration. Three patients with devascularized kidneys have been followed long term and have not developed hypertension. An IVP should be mandatory following severe blunt trauma, especially when hematuria is present. Renal arteriography is indicated with distortion of calyces, extravasation or nonfunction seen on IVP and allows a definitive diagnosis of renal vessel injury to be made.
Different 3′ untranslated regions target alternatively processed <i>hu-li tai shao</i> (<i>hts</i>) transcripts to distinct cytoplasmic locations during <i>Drosophila</i> oogenesis (1999)

Cytoplasmic mRNA localization is one method by which protein production is restricted to a particular intracellular site. We report here a novel mechanism for localization of transcripts encoding distinct protein isoforms to different destinations. Alternative processing of transcripts produced in the Drosophila ovary by the hu-li tai shao (hts) locus introduces distinct 3' untranslated regions (3'UTRs) that differentially localize the mRNAs. Three classes of hts mRNA (R2, N32 and N4) are synthesized in the germ line nurse cells and encode proteins with adducin-homologous amino-terminal regions but divergent carboxy-terminal domains. The R2 and N32 classes of mRNA remain in the nurse cells and are not transported into the oocyte. In contrast, the N4 class of transcripts is transported from the nurse cells into the oocyte starting at stage 1, is subsequently localized to the oocyte cortex at stage 8 and then to the anterior pole from stage 9 on. All aspects of N4 transcript transport and localization are directed by the 345-nucleotide(nt)-long 3' untranslated region (3'UTR). The organization of localization elements in the N4 3'UTR is modular: a 150 nt core is sufficient to direct transport and localization throughout oogenesis. Additional 3'UTR elements function additively together with this core region at later stages of oogenesis to maintain or enhance anterior transcript anchoring. The swallow locus is required to maintain hts transcripts at the anterior pole of the oocyte and functions through the N4 3'UTR. In addition to the three classes of germ line-expressed hts transcripts, a fourth class (R1) is expressed in the somatic follicle cells that surround the germ line cells. This transcript class encodes the Drosophila orthologue of mammalian adducin.
Nitrogen Management Strategies to Reduce Nitrate Leaching in Tile‐Drained Midwestern Soils (2002)

Balancing the amount of N needed for optimum plant growth while minimizing the NO 3 that is transported to ground and surface waters remains a major challenge for everyone attempting to understand and improve agricultural nutrient use efficiency. Our objectives for this review are to examine how changes in agricultural management practices during the past century have affected N in midwestern soils and to identify the types of research and management practices needed to reduce the potential for nonpoint NO 3 leakage into water resources. Inherent soil characteristics and management practices contributing to nonpoint NO 3 loss from midwestern soils, the impact of NO 3 loading on surface water quality, improved N management strategies, and research needs are discussed. Artificial drainage systems can have a significant impact on water quality because they behave like shallow, direct conduits to surface waters. Nonpoint loss of NO 3 from fields to water resources, however, is not caused by any single factor. Rather, it is caused by a combination of factors, including tillage, drainage, crop selection, soil organic matter levels, hydrology, and temperature and precipitation patterns. Strategies for reducing NO 3 loss through drainage include improved timing of N application at appropriate rates, using soil tests and plant monitoring, diversifying crop rotations, using cover crops, reducing tillage, optimizing N application techniques, and using nitrification inhibitors. Nitrate can also be removed from water by establishing wetlands or biofilters. Research that is focused on understanding methods to minimize NO 3 contamination of water resources should also be used to educate the public about the complexity of the problem and the need for multiple management strategies to solve the problem across agricultural landscapes.
Water dynamics in large and small reverse micelles: From two ensembles to collective behavior (2009)

The dynamics of water in Aerosol-OT reverse micelles are investigated with ultrafast infrared spectroscopy of the hydroxyl stretch. In large reverse micelles, the dynamics of water are separable into two ensembles: slow interfacial water and bulklike core water. As the reverse micelle size decreases, the slowing effect of the interface and the collective nature of water reorientation begin to slow the dynamics of the core water molecules. In the smallest reverse micelles, these effects dominate and all water molecules have the same long time reorientational dynamics. To understand and characterize the transition in the water dynamics from two ensembles to collective reorientation, polarization and frequency selective infrared pump-probe experiments are conducted on the complete range of reverse micelle sizes from a diameter of 1.6-20 nm. The crossover between two ensemble and collective reorientation occurs near a reverse micelle diameter of 4 nm. Below this size, the small number of confined water molecules and structural changes in the reverse micelle interface leads to homogeneous long time reorientation.
The Analytic Signal Representation of Modulated Waveforms (1962)

This report offers a rather general and mathematically convenient formulation of analog-modulated signals which makes use of the analytic signal concept. Known types of modulation are readily identified as special cases. As a result of examining the various cases which the model embraces, a new type of modulation has been discovered-single sideband frequency modulation (SSB FM)-which can be derived from a conventional phase-modulated signal by an additional amplitude modulation, using the exponential function of the modulating signal's Hilbert transform. The resulting modulated signal will have a one-sided spectrum about the carrier frequency, will be compatible with existing FM receivers, and will cause a decrease in signal bandwidth.
Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties. (1994)

We report properties of five active site mutants of Escherichia coli citrate synthase, in which histidine 264, aspartate 362, and phenylalanine 383 were replaced by alanines, and arginines 387 and 407 by leucines. All mutants have much lower turnover numbers than wild type enzyme; the strongest effect was with the arginine 387 mutant, perhaps because the substrate, oxaloacetate, binds in a different orientation. The arginine 407 mutant has lost most of its ability to distinguish alpha-ketoglutarate, a competitive inhibitor, from oxaloacetate. The mutations of histidine 264 and aspartate 362 affect steady-state kinetics as would be anticipated from current models for citrate synthase catalysis, and resemble mutations of these residues, in pig heart and E. coli enzyme, reported by others. Mutations of residues 264, 362, and 383 also affect allosteric properties. With the phenylalanine 383 mutant, acetyl-CoA saturation is strongly sigmoid, even in the presence of the activator, KCl, implying a marked shift of the allosteric equilibrium toward the T state. The histidine 264 mutant appears to be shifted toward R state and shows weaker binding of the allosteric inhibitor, NADH; thus this mutation also affects the allosteric site, 25-30 A away.