gebhart/patrepeval huggingface dataset:
Near-IR Two-Photon Photoinitiated Polymerization Using a Fluorone/Amine Initiating System (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNear-IR Two-Photon Photoinitiated Polymerization Using a Fluorone/Amine Initiating SystemKevin D. Belfield, Xiaobin Ren, Eric W. Van Stryland, David J. Hagan, Vladislav Dubikovsky, and Edward J. MiesakView Author Information Department of Chemistry School of Optics/Center for Research and Education in Optics and Lasers University of Central Florida, P.O. Box 162366 Orlando, Florida 32816 Cite this: J. Am. Chem. Soc. 2000, 122, 6, 1217–1218Publication Date (Web):January 26, 2000Publication History Received14 June 1999Revised8 October 1999Published online26 January 2000Published inissue 1 February 2000https://pubs.acs.org/doi/10.1021/ja991990vhttps://doi.org/10.1021/ja991990vrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1662Altmetric-Citations176LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption spectroscopy,Lasers,Light absorption,Monomers,Polymerization Get e-Alerts
A dynamic reaction coordinate approach to <i>a</i> <i>b</i> <i>i</i> <i>n</i> <i>i</i> <i>t</i> <i>i</i> <i>o</i> reaction pathways: Application to the 1,5 hexadiene Cope rearrangement (1990)

A modified dynamic reaction coordinate algorithm for tracing reaction paths is implemented in the framework of ab initio molecular orbital calculations. This method requires fewer energy and gradient evaluations than the traditional intrinsic reaction coordinate methodology and produces reaction pathways of acceptable accuracy. The approach is applied to the 1,5 hexadiene Cope rearrangement for which we trace the pathways passing through the chair and boat transition states. Analysis of the lowest energy pathway indicates that the rearrangement is concerted and synchronous.
Neutralizing linear epitopes of B19 parvovirus cluster in the VP1 unique and VP1-VP2 junction regions (1993)

Presentation of linear epitopes of the B19 parvovirus capsid proteins as peptides might be a useful vaccine strategy. We produced overlapping fusion proteins to span the viral capsid sequence, inoculated rabbits, and determined whether the resulting antisera contained antibodies that neutralized the ability of the virus to infect human erythroid progenitor cells. Antibodies that bound to virus in an enzyme-linked immunosorbent assay were present in antisera raised against 10 of 11 peptides; strongest activity was found for antisera against the carboxyl-terminal half of the major capsid protein. However, strong neutralizing activity was elicited in animals immunized with peptides from the amino-terminal portion of the unique region of the minor capsid protein and peptides containing the sequence of the junction region between the minor and major capsid proteins. The development of neutralizing activity in animals was elicited most rapidly with the fusion peptide from the first quarter of the unique region. A 20-amino-acid region of the unique region of the minor capsid protein was shown to contain a neutralizing epitope. Multiple antigenic peptides, based on the sequence of the unique region and produced by covalent linkage through a polylysine backbone, elicited strong neutralizing antibody responses. Synthetic peptides and fusion proteins containing small regions of the unique portion of the minor capsid protein might be useful as immunogens in a human vaccine against B19 parvovirus.
Dynamic regulation of <i>c‐Myc</i> proto‐oncogene expression during lymphocyte development revealed by a <i>GFP‐c‐Myc</i> knock‐in mouse (2008)

c-Myc induces widely varying cellular effects, including cell proliferation and cell death. These different cellular effects are determined, in part, by c-Myc protein expression levels, which are regulated through several transcriptional and post-transcriptional pathways. c-Myc transcripts can be detected in cells at all stages of B and T lymphocyte development. However, little is known about c-Myc protein expression, and how it varies, in developing lymphocytes. Here mice have been generated in which the endogenous c-Myc locus has been modified (c-Myc(G)) so that it encodes a GFP-c-Myc fusion protein. c-Myc(G/G) mice are viable, appear normal and exhibit grossly normal lymphocyte development. Flow cytometric analyses revealed significant heterogeneity in c-Myc protein expression levels in developing c-Myc(G/G) B and T lymphocytes. GFP-c-Myc expression levels were highest in proliferating lymphocytes, suggesting that c-Myc up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.
Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K‐AKT, WNT and TGFβ signalling pathways (2005)

Microarray studies have revealed the differential expression of several genes in mantle cell lymphoma (MCL), but it is unknown which of these differences are dependent on the transformed MCL cell itself or on the tumour microenvironment. To investigate which genes and signalling pathways are aberrantly expressed in MCL cells we used oligonucleotide microarrays to perform gene expression profiling of both purified leukaemic MCL cells and their normal counterparts, the naive B cells. A total of 106 genes were differentially expressed at least threefold in MCL cells compared with naive B cells; 63 upregulated and 43 downregulated. To validate the microarray results in a larger set of samples, we selected 10 differentially expressed genes and quantified their expression by real-time polymerase chain reaction in peripheral blood of MCL patients (n=21), purified MCL cells (n=6) and naive B cells (n=4), obtaining fully concordant results. A computer-assisted approach was used to procure specific molecular signalling pathways that were aberrantly expressed in MCL cells. Several genes related to apoptosis and to the PI3K/AKT, WNT and tumour growth factor beta signalling pathways were altered in MCL cells when compared with naive B cells. These pathways may play a significant role in the pathogenesis of MCL and deserve further investigation as candidates for new therapeutic targets.
Pixel circuits and drive schemes for glass and elastic AMOLED displays (2005)

Abstract— Flexible AMOLED displays pose unique opportunities and challenges for a‐Si. Leveraging the existing a‐Si process infrastructure is the fastest and lowest‐cost route to flexible AMOLEDs. However, the displays must maintain high performance, long lifetimes, and high uniformity despite low‐temperature processes and mechanical stress. New pixel circuits and drive schemes shown here demonstrate that high‐performance flexible AMOLED displays are possible using well‐established a‐Si technology.
Sequence Package Analysis: A New Natural Language Understanding Method for Performing Data Mining of Help-Line Calls and Doctor-Patient Interviews (2004)

Designers of audio mining programs must confront the complexities of natural language dialog, which is replete with ambiguities, circumlocutions and ellipses. Speakers often make requests, lodge complaints, or report on problems in such roundabout ways that attempts to find a statistically probable word match between the application vocabulary and the user's speech can yield unsatisfactory results. One solution to this problem is the application of Sequence Package Analysis (SPA) to perform intelligent data mining. The purpose of this paper is to demonstrate how Sequence Package Analysis, as a new AI-based natural language understanding method, can be used to gather important business intelligence by learning what customers are really complaining about when they make contact with customer call centers. The paper also looks at how SPA can be used in mining tape recordings of doctor- patient interviews to uncover important medical history data, often buried in the ambiguity of patient dialog. The paper, however, not only looks at the applications of SPA (e.g., industrial and medical), but demonstrates that SPA, as a new data mining technique, is an innovative heuristic approach to data mining that can bring machines one step closer to understanding humans.
Size Control of Porous Silicon Nanoparticles by Electrochemical Perforation Etching (2013)

Size‐controlled porous silicon‐based nanoparticles are prepared by pulsed electrochemical etching of single crystal silicon wafers, followed by ultrasonic fracture of the freestanding porous layer. When high‐current density pulses are applied periodically during the porous layer etching process, a porous multilayer results in which porous layers are separated by thin layers of much higher porosity. Ultrasonic fracture selectively cleaves the porous film along these high‐porosity perforations, providing greater size control and improved yields (by 5x) of the resulting porous nanoparticles. The effect of pulse width and repetition rate is systematically studied: tunability of the average nanoparticle size in the range 160–350 nm is demonstrated.
Definition of an innovative filling structure for digital blocks : the DFM filler cell (2009)

A DFM approach considers all interactions in the production flow and breaks the standard local/global context. Understanding existing solutions and their limitations in filling solution for digital blocks, we present in this paper a DFM filler cell solution that takes into account a large amount of problems that can be encountered at many steps of the production flow, such as lithography or planarity variations, while other kinds of filler cells only solve density problems. This allows designs to be less dependent on the global context of the digital block. Our DFM filler cell reduces the STI width stress impact, contains dummy polysilicon gates that allow an OPC-friendly approach and is more flexible for the place and route step. Our approach was validated by a silicon structure and many published data in this domain. The insertion of DFM filler cells is costless in terms of area thanks of their size that are multiple of the grid size. Furthermore, the usage of DFM filler cell in the complete design flow was validated.
Development of MIRAI system for heterogeneous wireless networks (2003)

A key word describing next-generation wireless communications, so called 4G, is "seamless." As part of the e-Japan Plan promoted by the Japanese government, the MIRAI (Multimedia Integrated network by Radio Access Innovation) project is aiming at the development of new technologies that will enable seamless integration of various wireless access systems for practical use by 2005. First, this paper describes heterogeneous wireless networks and introduces the concept of MIRAI. The most significant feature of MIRAI is the provision of a set of signaling functions: radio-access-network discovery and selection, heterogeneous paging, and vertical handoff. These functions make it possible to offer seamless services between different wireless systems. A medium access control (MAC) protocol for basic access networks, which are dedicated wireless systems providing the signaling, is then introduced. A proof-of-concept demonstration system is also briefly introduced. The delay performances of the signaling procedures are presented.
Plant ERD2‐like proteins function as endoplasmic reticulum luminal protein receptors and participate in programmed cell death during innate immunity (2012)

The hypersensitive response (HR), a form of programmed cell death (PCD), is a tightly regulated innate immune response in plants that is hypothesized to restrict pathogen growth and disease development. Although considerable efforts have been made to understand HR PCD, it remains unknown whether the retrograde pathway from the Golgi to the endoplasmic reticulum (ER) is involved. Here we provide direct genetic evidence that two Nicotiana benthamiana homologs, ERD2a and ERD2b, function as ER luminal protein receptors and participate in HR PCD. Virus-induced gene silencing (VIGS) of ERD2a and/or ERD2b caused escape of ER-resident proteins from the ER, and resulted in plants that were more sensitive to ER stress. Silencing of ERD2b delayed HR PCD induced by the non-host pathogens Xanthomonas oryzae pv. oryzae and Pseudomonas syringae pv. tomato DC3000. However, both silencing of ERD2a and co-silencing of ERD2a and ERD2b exacerbated HR PCD. Individual and combined suppression of ERD2a and ERD2b exaggerated R gene-mediated cell death. Nevertheless, silencing of ERD2a and/or ERD2b had no detectable effects on bacterial growth. Furthermore, VIGS of several putative ligands of ERD2a/2b, including the ER quality control (ERQC) component genes BiP, CRT3 and UGGT, had different effects on HR PCD induced by different pathogens. This indicates that immunity-related cell death pathways are separate with respect to the genetic requirements for these ERQC components. These results suggest that ERD2a and ERD2b function as ER luminal protein receptors to ensure ERQC and alleviate ER stress, thus affecting HR PCD during the plant innate immune response.
Synthesis of heteropolymetallic silanes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of heteropolymetallic silanesK. M. Abraham and Grant UrryCite this: Inorg. Chem. 1973, 12, 12, 2850–2856Publication Date (Print):December 1, 1973Publication History Published online1 May 2002Published inissue 1 December 1973https://pubs.acs.org/doi/10.1021/ic50130a022https://doi.org/10.1021/ic50130a022research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The TS-tree (2008)

Continuous growth in sensor data and other temporal data increases the importance of retrieval and similarity search in time series data. Efficient time series query processing is crucial for interactive applications. Existing multidimensional indexes like the R-tree provide efficient querying for only relatively few dimensions. Time series are typically long which corresponds to extremely high dimensional data in multidimensional indexes. Due to massive overlap of index descriptors, multidimensional indexes degenerate for high dimensions and access the entire data by random I/O. Consequently, the efficiency benefits of indexing are lost.
Animal Models of Drug‐Resistant Epilepsy (2002)

It is not known why and how epilepsy becomes drug resistant in 20-30% of patients, while other patients with seemingly identical seizure types can achieve control of seizures with medication. An animal model of epilepsy allowing selection of pharmacoresistant and pharmacosensitive subgroups of animals would be a valuable tool to study mechanisms of pharmacoresistance and to develop more effective treatment strategies. Only a few models are available which mimic patterns of drug resistance in humans with epilepsy. One model seems to be particularly interesting: amygdala-kindled rats. In this model in Wistar rats, animals which do not respond to repeated or chronic administration of anti-epileptic drugs (non-responders) can be separated from animals in whom anti-epileptics are effective (responders). Hence, pharmacoresistant subgroups of kindled rats provide a unique tool to study why seizures become intractable, particularly because pathophysiological processes in these resistant rats can be directly compared with those of kindled rats that respond to treatment. By using this model, we have recently shown that both the individual genetic background and kindling-induced processes determine whether a rat becomes a responder or a non-responder to anticonvulsant treatment after kindling. We are currently studying the cellular mechanisms underlying the development of drug-resistant kindled seizures.
Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. (1994)

A cDNA clone for a new rat metabotropic glutamate receptor termed mGluR7 was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic receptor (mGluR) family and by the subsequent screening of a rat forebrain cDNA library. The cloned mGluR7 subtype consists of 915 amino acid residues and exhibits a structural architecture common to the mGluR family with a large extracellular domain preceding the seven putative membrane-spanning domains. mGluR7 shows the highest sequence similarity to mGluR4 and mGluR6 among the members of the mGluR family. Similar to mGluR4 and mGluR6, mGluR7 inhibits forskolin-stimulated cyclic AMP accumulation in response to agonist interaction and potently reacts with L-2-amino-4-phosphonobutyrate and L-serine-O-phosphate in Chinese hamster ovary cells transfected with the cloned cDNA. RNA blot and in situ hybridization analyses of mGluR7 mRNA indicated that it is widely expressed in many neuronal cells of the central nervous system and is thus different from the more limitedly expressed mGluR4 or mGluR6 mRNA. mGluR7 together with mGluR4 thus corresponds to the putative L-2-amino-4-phosphonobutyrate receptor which plays an important role in modulation of glutamate transmission in the central nervous system.
Photochemical and photophysical properties of tetranuclear and hexanuclear clusters of metals with d10 and s2 electronic configurations (1993)

A number of the d10and s2metal clusters are brightly luminescent, some with strongly medium dependent and temperature dependent spectral profiles. Such emissions are often from excited states assigned as having a mixed d-s/XMCT character, the key feature being enhanced electronic population in metal-metal bonding orbitals in these states as evidenced by the large Stokes shifts between excitation and emission maxima. The observation of such emission bands is strongly favored by relatively short metal-metal distances in the clusters. This behavior parallels that of the d8-d8dimers held by bridging ligands in cofacial configurations for which excitation leads to substantially increased bonding between metal centers. With Ï-unsaturated ligands L, emissions from XLCT excited states are often observed, and the luminescence thermochromism of such complexes is the result of different temperature and medium rigidity responses of these two types of excited states. The poor coupling between d-s/XMCT and XLCT states in clusters such as Cu4I4-(py)4can be attributed to high barrier heights for curve crossing owing to different distortion trajectories once the molecule is prepared in one of the respective excited states. Ongoing studies in these laboratories continue to survey different luminative d10and s2cluster systems and to apply an arsenal of synthetic, theoretical, photophysical, and photochemical tools to extend our quantitative understanding of the relevant excited states. Â© 1993, American Chemical Society. All rights reserved.
Level-line moirés by superposition of cylindrical microlens gratings (2020)

Two superposed layers of transparent cylindrical lenslet gratings create classical moiré fringes when illuminated from behind. We rely on this observation to conceive special devices made of superposed lenslet gratings that produce compelling beating shapes when tilted against the light. Level-line moirés are created by superposing gratings of cylindrical lenslets of the same period on both sides of a substrate and by locally shifting some of the cylindrical lenses according to the moiré theory. Depending on the illumination and the viewing conditions, constant light intensities or colors move across graphical elements or faces. Such level-line moiré samples have been fabricated and characterized to determine the optimal fabrication parameters. Thanks to their striking visual appeal and their relatively challenging fabrication, moirés created by superposition of lenslets have a high potential for document security, art, and decoration.
Nucleic acid related compounds. 73. Fluorination of uridine 2'-thioethers with xenon difluoride or (diethylamino)sulfur trifluoride. Synthesis of stable 2'-[alkyl(or aryl)sulfonyl]-2'-deoxy-2'-fluorouridines (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleic acid related compounds. 73. Fluorination of uridine 2'-thioethers with xenon difluoride or (diethylamino)sulfur trifluoride. Synthesis of stable 2'-[alkyl(or aryl)sulfonyl]-2'-deoxy-2'-fluorouridinesMorris J. Robins, Khairuzzaman B. Mullah, Stanislaw F. Wnuk, and N. Kent DalleyCite this: J. Org. Chem. 1992, 57, 8, 2357–2364Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/jo00034a031https://doi.org/10.1021/jo00034a031research-articleACS PublicationsRequest reuse permissionsArticle Views362Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts