gebhart/patrepeval huggingface dataset:
Determination of Pacing Capture in Implantable Defibrillators: Benefit of Evoked Response Detection Using RV Coil to Can Vector (2000)

Automatic detection of capture in ICDs would be useful for ensuring normal pacing function and lead integrity and may increase device longevity. Evoked response detection can be difficult due to postpace polarization. Polarization on the RV coil to can vector, however, should be absent when pacing with a true bipolar lead (pace tip to ring). Polarization on the RV coil to can vector should be low in an integrated bipolar lead due to the large surface area of the coil. Ventricular-paced responses were prospectively recorded in 20 patients during ICD implantation or replacement. Capture and loss of capture responses were noted during threshold searches with electrograms recorded between the RV coil and can. A detector was designed to discriminate between capture and noncapture-paced responses using data from the first 11 patients and validated on the remaining 9. The detector had a sensitivity of 99.9% (detected capture on capture beats), and had a specificity of 100% (detected no capture on noncapture beats) for all lead configurations. There was no measurable polarization with true bipolar leads. In integrated bipolar leads, maximum polarization ranged from 0.0 to 16.7 mV. In conclusion, paced evoked responses can be detected in ICDs using the RV coil to can vector using standard pacing waveforms. Special polarization reducing pacing waveforms are not required. These observations could be used to design ICDs with automatic pacing threshold detection.
Isolation, purification, and stereochemistry of simmondsin (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation, purification, and stereochemistry of simmondsinM. Van Boven, N. Blaton, M. Cokelaere, and P. DaenensCite this: J. Agric. Food Chem. 1993, 41, 10, 1605–1607Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://doi.org/10.1021/jf00034a015RIGHTS & PERMISSIONSArticle Views132Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (368 KB) Get e-Alerts Get e-Alerts
A Study of Relationships Between Flatus Potential and Carbohydrate Distribution in Legume Seeds (1981)

ABSTRACT The objective of this study was to investigate the relationship between flatulence potencial and carbohydrate composition of legume seeds. The navy bean, red kidney bean and wrinkled‐seeded field pea induced the highest levels of hydrogen to be produced by the laboratory rat. The garbanzo bean and smooth‐seeded field pea gave intermediate values whereas the mung bean and green lentil showed values which were not significantly different from the control, non‐flatulent diet. Significant, positive correlations were determined between hydrogen production and the following chemical components: stachyose, raffinose plus stachyose, and glucans and pentosans hydrolyzable in dilute acid. Significant, negative correlations were determined between hydrogen production and starch or lignin contents.
A review of measures of lymphedema (1998)

Existing physical measures of lymphedema are available that are easy to use, inexpensive, have limited reliability, and do not address the issue of functional impact. Imaging techniques may provide valuable qualitative and quantitative information in selected populations.
Weak-Inversion Measurement Circuit for Miniature Electrical Capacitance Tomography (2008)

This paper describes the design of the front-end measurement circuit for a miniature electrical capacitance tomography system. This is based on a charge-transfer circuit and is implemented as a custom CMOS integrated circuit that is mounted close to the electrodes to reduce parasitic capacitance. The design has been informed by a 3-D finite-element simulation using the Ansoft Maxwell software. Simulation results suggest that, with averaging, a minimum measurable capacitance change of 100 aF (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-16</sup> F) is possible. This paper presents an analytical description of the circuit which, uniquely for such an application, is based on MOSFETs operating in weak inversion. The system has an average sensitivity of 40 mV/fF and can deliver an unprecedented 6250 measurement frames/s. The sensor comprises eight electrodes that are formed on a conical orifice, fabricated using ultrasonic drilling and a minimum diameter of 0.5 mm, through a ceramic substrate. The cross-sectional tomographic images of static objects, which are reconstructed offline, are presented.
Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. (1990)

The messenger RNAs and core proteins of the two small chondroitin/dermatan sulfate proteoglycans, biglycan and decorin, were localized in developing human bone and other tissues by both 35S-labeled RNA probes and antibodies directed against synthetic peptides corresponding to nonhomologous regions of the two core proteins. Biglycan and decorin expression and localization were substantially divergent and sometimes mutually exclusive. In developing bones, spatially restricted patterns of gene expression and/or matrix localization of the two proteoglycans were identified in articular regions, epiphyseal cartilage, vascular canals, subperichondral regions, and periosteum, and indicated the association of each molecule with specific developmental events at specific sites. Study of non-skeletal tissues revealed that decorin was associated with all major type I (and type II) collagen-rich connective tissues. Conversely, biglycan was expressed and localized in a range of specialized cell types, including connective tissue (skeletal myofibers, endothelial cells) and epithelial cells (differentiating keratinocytes, renal tubular epithelia). Biglycan core protein was localized at the cell surface of certain cell types (e.g., keratinocytes). Whereas the distribution of decorin was consistent with matrix-centered functions, possibly related to regulation of growth of collagen fibers, the distribution of biglycan pointed to other function(s), perhaps related to cell regulation.
Expression of the Pokemon Proto-oncogene in Nasopharyngeal Carcinoma Cell Lines and Tissues (2013)

To study the differentiated expression of the proto-oncogene Pokemon in nasopharyngeal carcinoma (NPC) cell lines and tissues, mRNA and protein expression levels of CNE1, CNE2, CNE3 and C666-1 were detected separately by reverse transcription polymerase chain reaction (RT-PCR), real-time PCR and Western-blotting. The immortalized nasopharyngeal epithelial cell line NP69 was used as a control. The Pokemon protein expression level in biopsy specimens from chronic rhinitis patients and undifferentiated non keratinizing NPC patients was determined by Western-blotting and arranged from high to low: C666-1>CNE1>CNE2> CNE3>NP69. The Pokemon mRNA expression level was also arranged from high to low: CNE1>CNE2>NP69>C666-1>CNE3. Pokemon expression of NP69 and C666-1 obviously varied from mRNA to protein. The Pokemon protein level of NPC biopsy specimens was obviously higher than in chronic rhinitis. The data suggest that high Pokemon protein expression is closely associated with undifferentiated non-keratinizing NPC and may provide useful information for NPC molecular target therapy.
Modulation of experimental autoimmune encephalomyelitis by endogenous Annexin A1 (2009)

Together these findings suggest that Annexin A1 null mice have an impaired capacity to develop EAE. Furthermore strategies aiming at reducing Annexin A1 functions or expression in T cells might represent a novel therapeutic approach for multiple sclerosis.
Physical mapping of the globin gene deletion in hereditary persistence of foetal haemoglobin (HPFH) (1980)

We have mapped the globin gene region in the DNA of two HPFH patients. In a patient homozygous for the G gamma A gamma type of HPFH at least 24 kb of DNA in the globin gene region has been deleted to remove most of the gamma-delta intergenic region and the delta and beta globin genes. The 5' break point of the deletion is located about 9 kb upstream from the delta globin gene. The 3' break point has not been precisely located but is at least 7 kb past the beta globin gene. DNA from an individual heterozygous for the Greek (A gamma) type of HPFH, however, shows no detectable deletion in the entire gamma delta beta-globin gene region. HPFH, therefore, appears to occur in different molecular forms. These results are discussed in terms of a model for the regulation of globin gene expression in man.
Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo (1999)

Eukaryotic translation initiation factor 4E (eIF4E) binds to the mRNA 5' cap and brings the mRNA into a complex with other protein synthesis initiation factors and ribosomes. The activity of mammalian eIF4E is important for the translation of capped mRNAs and is thought to be regulated by two mechanisms. First, eIF4E is sequestered by binding proteins, such as 4EBP1, in quiescent cells. Mitogens induce the release of eIF4E by stimulating the phosphorylation of 4EBP1. Second, mitogens and stresses induce the phosphorylation of eIF4E at Ser 209, increasing the affinity of eIF4E for capped mRNA and for an associated scaffolding protein, eIF4G. We previously showed that a mitogen- and stress-activated kinase, Mnk1, phosphorylates eIF4E in vitro at the physiological site. Here we show that Mnk1 regulates eIF4E phosphorylation in vivo. Mnk1 binds directly to eIF4G and copurifies with eIF4G and eIF4E. We identified activating phosphorylation sites in Mnk1 and developed dominant-negative and activated mutants. Expression of dominant-negative Mnk1 reduces mitogen-induced eIF4E phosphorylation, while expression of activated Mnk1 increases basal eIF4E phosphorylation. Activated mutant Mnk1 also induces extensive phosphorylation of eIF4E in cells overexpressing 4EBP1. This suggests that phosphorylation of eIF4E is catalyzed by Mnk1 or a very similar kinase in cells and is independent of other mitogenic signals that release eIF4E from 4EBP1.
On the Choice of Modeling Unit for Sequence-to-Sequence Speech Recognition (2019)

In conventional speech recognition, phoneme-based models outperform grapheme-based models for non-phonetic languages such as English. The performance gap between the two typically reduces as the amount of training data is increased. In this work, we examine the impact of the choice of modeling unit for attention-based encoder-decoder models. We conduct experiments on the LibriSpeech 100hr, 460hr, and 960hr tasks, using various target units (phoneme, grapheme, and word-piece); across all tasks, we find that grapheme or word-piece models consistently outperform phoneme-based models, even though they are evaluated without a lexicon or an external language model. We also investigate model complementarity: we find that we can improve WERs by up to 9% relative by rescoring N-best lists generated from a strong word-piece based baseline with either the phoneme or the grapheme model. Rescoring an N-best list generated by the phonemic system, however, provides limited improvements. Further analysis shows that the word-piece-based models produce more diverse N-best hypotheses, and thus lower oracle WERs, than phonemic models.
The pharmacogenetics of methotrexate (2007)

Methotrexate (MTX) is a cornerstone of therapy for rheumatoid arthritis. However, it is not universally effective and up to one-third of patients fail to respond to treatment, either because of inefficacy or adverse events, although at present it is not possible to predict therapy response accurately. Pharmacogenetics is the study of variability in drug response due to heredity. MTX has a complex intracellular metabolism and acts via a number of key enzymes. This review critically appraises the studies of MTX pharmacogenetics and highlights the need for further work in this area.
Fabrication of Si nanostructures with an atomic force microscope (1994)

A method for fabricating Si nanostructures with an air-operated atomic force microscope (AFM) is presented. An electrically conducting AFM tip is used to oxidize regions of size 10–30 nm of a H-passivated Si (100) surface at write speeds up to 1 mm/s. This oxide serves as an effective mask for pattern transfer into the substrate by selective liquid etching. The initial oxide growth rate depends exponentially on the applied voltage which produces an effective ‘‘tip sharpening’’ that allows small features to be produced by a relatively large diameter tip.
Argon laser treatment of telangiectasia of the face and neck: 5 Years' experience (1987)

Abstract This study documents the treatment and long‐term follow‐up of telangiectasias of the face and neck with the argon laser. This study concurs with other examiners that treatment is effective with minimal complications and satisfactory long‐term results.
Design, Synthesis, and Structure−Activity Relationship Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1<i>H</i>-pyrrol-2(5<i>H</i>)-one Analogues as Inhibitors of the Annexin A2−S100A10 Protein Interaction (2011)

S100 proteins are small adaptors that regulate the activity of partner proteins by virtue of direct protein interactions. Here, we describe the first small molecule blockers of the interaction between S100A10 and annexin A2. Molecular docking yielded candidate blockers that were screened for competition of the binding of an annexin A2 peptide to S100A10. Several inhibitory clusters were identified with some containing compounds with potency in the lower micromolar range. We chose 3-hydroxy-1-(2-hydroxypropyl)-5-(4-isopropylphenyl)-4-(4-methylbenzoyl)-1H-pyrrol-2(5H)-one (1a) as a starting point for structure-activity studies. These confirmed the hypothetical binding mode from the virtual screen for this series of molecules. Selected compounds disrupted the physiological complex of annexin A2 and S100A10, both in a broken cell preparation and inside MDA-MB-231 breast cancer cells. Thus, this class of compounds has promising properties as inhibitors of the interaction between annexin A2 and S100A10 and may help to elucidate the cellular function of this protein interaction.
Sparse Non‐rigid Registration of 3D Shapes (2015)

Abstract Non‐rigid registration of 3D shapes is an essential task of increasing importance as commodity depth sensors become more widely available for scanning dynamic scenes. Non‐rigid registration is much more challenging than rigid registration as it estimates a set of local transformations instead of a single global transformation, and hence is prone to the overfitting issue due to underdetermination. The common wisdom in previous methods is to impose an ℓ 2 ‐norm regularization on the local transformation differences. However, the ℓ 2 ‐norm regularization tends to bias the solution towards outliers and noise with heavy‐tailed distribution, which is verified by the poor goodness‐of‐fit of the Gaussian distribution over transformation differences. On the contrary, Laplacian distribution fits well with the transformation differences, suggesting the use of a sparsity prior. We propose a sparse non‐rigid registration (SNR) method with an ℓ 1 ‐norm regularized model for transformation estimation, which is effectively solved by an alternate direction method (ADM) under the augmented Lagrangian framework. We also devise a multi‐resolution scheme for robust and progressive registration. Results on both public datasets and our scanned datasets show the superiority of our method, particularly in handling large‐scale deformations as well as outliers and noise.
Hb G-MAKASSAR [<b>β</b>6(A3)Glu→Ala; CODON 6 (G<b><i>A</i></b>G→G<b><i>C</i></b>G)]: MOLECULAR CHARACTERIZATION, CLINICAL, AND HEMATOLOGICAL EFFECTS (2002)

We report a Thai family in which five members are Hb G-Makassar heterozygotes and one member is, in addition, a heterozygote for beta0-thalassemia (IVS-I-1, G-->T). We confirm that the previously presumed mutation at codon 6 of the beta-globin gene is GAG-->GCG. Hb G-Makassar heterozygotes are asymptomatic and hematologically normal. The Hb G-Makassar/beta0-thalassemia compound heterozygote has features of thalassemia minor. A simple and rapid polymerase chain reaction-restriction fragment length polymorphism for the detection of Hb G-Makassar is described.
Desert Subterranean Termites: A Method for Studying Foraging Behavior1,2 (1973)

Subterranean termites are among the most abundant but cryptic of animals, a factor making behavioral studies very difficult. Consequently little is known of their foraging behavior or general activity patterns. Previous studies have been restricted mainly to mound builders (Bouillon and Lekie 1964) or harvesters which forageopenly on the soil surface (Bouillon 1970, Nel 1968). A few estimates of subterranean termite populations have been based on baiting with attractive materials or soilcore sampling (Sands 1972).
Targeted adenoviral vectors (2002)

The practical implementation of gene therapy in the clinical setting mandates gene delivery vehicles, or vectors, capable of efficient gene delivery selectively to the target disease cells. The utility of adenoviral vectors for gene therapy is restricted by their dependence on the native adenoviral primary cellular receptor for cell entry. Therefore, a number of strategies have been developed to allow CAR-independent infection of specific cell types, including the use of bispecific conjugates and genetic modifications to the adenoviral capsid proteins, in particular the fibre protein. These targeted adenoviral vectors have demonstrated efficient gene transfer in vitro, correlating with a therapeutic benefit in preclinical animal models. Such vectors are predicted to possess enhanced efficacy in human clinical studies, although anatomical barriers to their use must be circumvented.
Conjugal transfer of plasmid pAMÎ²1 from<i>Streptococcus lactis</i>and<i>Bacillus subtilis</i>to<i>Clostridium acetobutylicum</i> (1985)

A filter mating procedure has been used to transfer the plasmid pAMβ1 from Streptococcus lactis to Clostridium acetobutylicum at high efficiency. Once established in this latter host the plasmid can be transferred, with lower efficiency to other strains of C. acetobutylicum or back to S. lactis. A procedure has also been developed for the co-cultivation of Bacillus subtilis and C. acetobutylicum and the transfer of pAMβ1 between these organisms has been demonstrated.
NSAIDs: Mechanisms and Pathways of Action (1989)

The therapeutic effects of NSAIDs have been considered merely palliative rather than disease modifying, especially in conditions having an immunologic component. This view may be too limited. Recent research indicates that these agents may alter the immune response directly, acting on immunocompetent cells, and indirectly, through inhibition of prostaglandin biosynthesis.
Synthesis and antiestrogenic activity of [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone, methanesulfonic acid salt (1979)

Acylation of the sodio anion of beta-tetralone with phenyl anisoate, followed by a Grignard reaction of the resultant 4 with 4-methoxyphenylmagnesium bromide, gave rise to two novel dihydronaphthalene isomers 5 and 6. Regioselective demethylation of either 5 or 6 by NaSEt produced [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthalenyl](4-hydroxyphenyl)methanone (7). Etherification of the phenolic group of 7 by N-(2-chloroethyl)pyrrolidine and subsequent methanesulfonate salt formation provided [3,4-dihydro-2-(4-methoxyphenyl)-1-maphthalenyl]]4-]2-(1-pyrrolidinyl)ethoxy]phenyl]methanone, methane sulfonic acid salt (3). Potent antiestrogenic activity of 3 was demonstrated by both oral and subcutaneous administration to rats and mice. In vitro binding studies with rat uterine cytosol estrogen receptors indicate compound 3 has a very high binding affinity which exceeds that of estradiol.
Selenium deficiency increases the pathology of an influenza virus infection (2001)

ABSTRACT Selenium (Se) deficiency has previously been shown to induce myocarditis in mice infected with a benign strain of coxsackievirus. To determine if Se deficiency would also intensify an infection with influenza virus, Se‐deficient and Se‐adequate mice were infected with a mild strain of influenza, influenza A/Bangkok/1/79 (H3N2). Infected Se‐deficient mice developed much more severe interstitial pneumonitis than did Se‐adequate mice. This increase in pathology was associated with significant alterations in mRNA levels for cytokines and chemokines involved in pro‐inflammatory responses. These results demonstrate that adequate nutrition is required for protection against viral infection and suggest that nutritional deprivation may be one of many factors that increase the susceptibility of individuals to influenza infection.
Porous Silicon Photonic Crystals as Encoded Microcarriers (2004)

A simple method used to construct microparticles of porous Si photonic crystals that display highly resolved and easily controlled optical diffraction peaks is described. The spectral diffraction peaks can act as digits in an encoding scheme, and the possibility of generating particle libraries with >106 distinct codes is demonstrated (see Figure). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2004/c0713_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Analysis of resource sharing in information providing services (2002)

The key to an economical service is in the sharing of physical resources among the customers. This applies to the information storage and sourcing devices, as well as to the transmission bandwidth. One of the possible solutions to the resource sharing problem is the grouping of customers with similar service requests, and broadcasting the information rather than granting the service individually. The customers' behavior (in particular, the customers' patience) is modeled, and the service performance for different service scenarios is analyzed. It is shown that in case of the threshold-activated service scenario, it is possible to optimize the service performance by using the statistics of the service requests and customer patience.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>