gebhart/patrepeval huggingface dataset:
A cascaded scheme for eye tracking and head movement compensation (1998)

The authors previously (1995) proposed an efficient method for tracking the eye movements. The proposed algorithm did not address the issue of compensating for head movements. Head movements are normally much slower than eye movements and can be compensated for using another tracking scheme for head position. In this paper, a hybrid method employing the two tracking schemes is developed. To this end, first a measurement model for the compensation of the head movement is formulated and then the overall tracking scheme is implemented by cascading two Kalman filters. The tracking of the iris movement is followed by the compensation of the head movement for each image frame. Experimental results are presented to demonstrate the accuracy aspects and the real-time applicability of the proposed approach.
Mass Spectrometric Profiling of Vitamin D Metabolites beyond 25-Hydroxyvitamin D (2015)

To study the pathobiological effects and function of vitamin D metabolites in disease, in particular in low-abundance species beyond 25-hydroxyvitamin D, we need to know their concentrations. Although detection of these vitamin D species is challenging, a number of recent mass spectrometry assays have successfully demonstrated that LC-MS/MS methods can quantify multiple vitamin D compounds over a wide dynamic range individually or as part of multimetabolite assays.
Soft Transfer Printing of Chemically Converted Graphene (2009)

A transfer printing process that allows precise patterning of chemically converted graphene is reported. The use of a polydimethylsiloxane (PDMS) stamp and surface energy manipulation resulted in successfully transferring spin-coated materials from one substrate to another. The method is capable of transferring sharp features to precise locations. This represents large-scale, high-throughput transfer printing of chemically converted graphene and paves the way for future complementary circuit design. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Spatial control in the heterogeneous nucleation of water (2009)

Heterogeneous nucleation of water plays an important role in a wide range of natural and industrial processes. Though heterogeneous nucleation of water is ubiquitous and an everyday experience, spatial control of this important phenomenon is extremely difficult. Here we show for the first time that spatial control in the heterogeneous nucleation of water can be achieved by manipulating the local nucleation energy barrier and nucleation rate via the modification of the local intrinsic wettability of a surface. Such ability to control water nucleation could address the condensation-related limitations of superhydrophobic surfaces and has implications for efficiency enhancements in energy and desalination systems.
Epidermal growth factor receptor (EGFR) as a prognostic marker: an immunohistochemical study on 315 consecutive breast carcinoma patients. (2002)

Objective: To assess the independent and interdependent prognostic value of epidermal growth factor receptor (EGFR) in carcinoma of breast in female population. The Type I family of growth factor receptors includes epidermal growth factor receptor (EGFR also known as EGFRI). Methods: The expression of EGFR protein was analysed immunohistochemically on 315 tumour specimens of infiltrating ductal carcinoma of breast. These patients also had axillary lymph nodes sampling. Results: Overexpression and/or amplification of EGFR was observed in 70 (22.00%) tumours. Eleven (16%) were grade I, 43 (61%) grade II and 16 (23%) grade Ill tumours. Axillary lymph node metastasis had significant correlation with intensified positivity of EGFR (p< 0.05). Significant number of EGFR positive patients developed local recurrence and distant metastases to brain, liver and bone (p< 0.05). EGFR positivity showed significant correlation with the disease free and overall survival (p< 0.05). At a median follow-up of48 (4 years) months in EGFR positive patients, the overall survival was 3.39 years and disease free survival was 2.86 years. EGFR negative tumour patients showed a better survival. In this group the overall survival was 4.62 years and the disease free survival was 4 years. Conclusion: EGFR analysis can be a useful indicator for the selection of patients who are at the high risk, for hormonal therapy decisions and can be useful as a target for new treatment modalities.
Analysis of the critical sites for protein thermostabilization by proline substitution in oligo-1,6-glucosidase from Bacillus coagulans ATCC 7050 and the evolutionary consideration of proline residues (1996)

To identify the critical sites for protein thermostabilization by proline substitution, the gene for oligo-1,6- glucosidase from a thermophilic Bacillus coagulans strain, ATCC 7050, was cloned as a 2.4-kb DNA fragment and sequenced. In spite of a big difference in their thermostabilities, B. coagulans oligo-1,6-glucosidase had a large number of points in its primary structure identical to respective points in the same enzymes from a mesophilic Bacillus cereus strain, ATCC 7064 (57%), and an obligately thermophilic Bacillus thermoglucosidasius strain, KP1006 (59%). The number of prolines (19 for B. cereus oligo-1,6-glucosidase, 24 for B. coagulans enzyme, and 32 for B. thermoglucosidasius enzyme) was observed to increase with the rise in thermostabilities of the oligo-1,6-glucosidases. Classification of proline residues in light of the amino acid sequence alignment and the protein structure revealed by X-ray crystallographic analysis also supported this tendency. Judging from proline residues occurring in B. coagulans oligo-1,6-glucosidase and the structural requirement for proline substitution (second site of the beta turn and first turn of the alpha helix) (K. Watanabe, T. Masuda, H. Ohashi, H. Mihara, and Y. Suzuki, Eur. J. Biochem. 226:277-283, 1994), the critical sites for thermostabilization were found to be Lys-121, Glu-290, Lys-457, and Glu-487 in B. cereus oligo-1,6-glucosidase. With regard to protein evolution, the oligo-1,6-glucosidases very likely follow the neutral theory. The adaptive mutations of the oligo-1,6-glucosidases that appear to increase thermostability are consistent with the substitution of proline residues for neutrally occurring residues. It is concluded that proline substitution is an important factor for the selection of thermostability in oligo-1,6-glucosidases.
A novel high-Q inductor based on Si 3D MMIC technology and its application (2003)

A novel high-Q spiral inductor, implemented on a conductive Si wafer by applying a 3D MMIC structure over it, is proposed. The proposed inductor effectively uses a 10-/spl mu/m-thick polyimide layer and ground plane with a window below the spiral. A Q-factor of 21.7 at 1.88 nH and 5.8 GHz is achieved. A 5 GHz-band LNA is also designed with the new inductors and Si BJT with f/sub max/ of 24 GHz, and the highest-class of performance was predicted with a 20 dB gain and a 2.5 dB noise figure.
Characterization of copolymers fractionated using supercritical fluids (1987)

In this study supercritical fluids were used to process several different types of oligomers. Supercritical fluid processing was found to be quite effective at removing low vapor pressure monomers from polymers and for fractionation of polymers according to molecular weight. This resulted in high purity materials with low M̄w/M̄n ratios. The polymer fractions obtained were analyzed by size exclusion chromatography, differential scanning calorimetry, and melt rheometry. Their physical and chemical properties are described.
Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS) (1983)

Several isolates of a human type-C retrovirus belonging to one group, known as human T-cell leukemia virus (HTLV), have previously been obtained from patients with adult T-cell leukemia or lymphoma. The T-cell tropism of HTLV and its prevalence in the Caribbean basin prompted a search for it in patients with the epidemic T-cell immune deficiency disorder known as AIDS. Peripheral blood lymphocytes from one patient in the United States and two in France were cultured with T-cell growth factor (TCGF) an shown to express HTLV antigens. Virus from the U.S. patient was isolated and characterized and shown to be related to HTLV subgroup I. The virus was also transmitted into normal human T cells from umbilical cord blood of a newborn. Whether or not HTLV-I or other retroviruses of this family with T-cell tropism cause AIDS, it is possible that patients from whom the virus can be isolated can also transmit it to others. If the target cell of AIDS is the mature T cell as suspected, the methods used in these studies may prove useful for the long-term growth of these cells and for the identification of antigens specific for the etiological agent of AIDS.
Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. (2002)

SAMe appears to be as effective as NSAIDs in reducing pain and improving functional limitation in patients with OA without the adverse effects often associated with NSAID therapies.
Cache Replacement Policies for Cooperative Caching in Mobile Ad hoc Networks (2012)

Cooperative caching is a technique used in mobile ad hoc networks to improve the efficiency of information access by reducing the access latency and bandwidth usage. Cache replacement policy plays a significant role in response time reduction by selecting suitable subset of items for eviction from the cache. In this paper we have made a review of the existing cache replacement algorithms proposed for cooperative caching in ad hoc networks. We made an attempt to classify existing replacement policies for ad hoc networks based on the replacement decision taken. In addition, this paper suggests some alternative techniques for cache replacement. Finally, the paper concludes with a discussion on future research directions.
Evaluating swabbing (2011)

Elderly users suffering from hand tremor have difficulties interacting with touchscreens because of finger oscillation. It has been previously observed that sliding one's finger across the screen may help reduce this oscillation. In this work, we empirically confirm this advantage by (1) measuring finger oscillation during different actions and (2) comparing error rate and user satisfaction between traditional tapping and swabbing in which the user slides his finger towards a target on a screen edge to select it. We found that oscillation is generally reduced during sliding. Also, compared to tapping, swabbing resulted in improved error rates and user satisfaction. We believe that swabbing will make touchscreens more accessible to senior users with tremor.
Interlocked test generation and digital hardware synthesis (2002)

Digital hardware synthesis implies the use of clock mode register transfer level descriptions. A major feature of this approach to synthesis is the possibility of integrating test generation into the design and synthesis process. Preliminary synthesis makes it possible to link test search at the function level to fault enumeration at the network level. A recently developed backward state justification search has eliminated the final bottleneck in automatic test generation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A critical analysis of Ontario’s resource-based tourism policy (2010)

Conflicts between resource-based industries and resource-based tourism are commonplace, complex, and long lived. The Resource-Based Tourism Policy (Government of Ontario, 1997) was one of a number of documents produced by the Government of Ontario in response to such conflicts in Northern Ontario, Canada. Yet in the 13 years since the policy was produced, there has been no research to examine either the impact or effectiveness of this document in achieving its stated goal: “to promote and encourage the development of the Ontario resource-based tourism industry in both an ecologically and economically sustainable manner” (Government of Ontario, 1997, p. 1). This article reviews the context within which the policy operates, summarizes the policy document, and questions both the impact and effectiveness of the Resource-Based Tourism Policy based on five critiques: (a) the level of transparency, collaboration, and representation in the policy’s development; (b) the unity of the policy direction and actions; (c) the incorporation of science into proposed policy solutions; (d) the adaptability of the policy to changing industry and contextual trends; and (e) the completeness of the policy’s implementation. In conclusion, we suggest that it is time to revisit, reexamine, adapt, and update this policy document in consideration of current trends in the industry and contextual factors.
The Use of Cyclopenta[2,1‐<i>b</i>;3,4‐<i>b</i>′]dithiophene Analogues for the Development of Low‐Bandgap Materials (2012)

Abstract This paper presents the synthesis and characterization of low‐bandgap materials based on cyclopenta[1,2‐ b ;3,4‐ b ′]dithiophene (CPDT). An array of electron‐poor monomers is synthesized and used to prepare homo‐ and alternating donor–acceptor copolymers. This yields polymers with low bandgaps ( E g = 1.12–1.23 eV) and broad light absorption (400–1100 nm). The influence of the electron‐withdrawing substituent and the donor material on the polymer properties is studied. It is demonstrated that the low bandgap is not a result of intramolecular charge transfer, but of a transition localized in the electron‐poor CPDT monomer. The bandgap can be correlated with the substituent on the CPDT monomer and is relatively independent of other parameters, resulting in materials with an easily tunable bandgap.
[Effect of trimethylglycine on lipid metabolism in experimental atherosclerosis in rabbits]. (1983)

It has been shown in adult rabbits aged 8 months with experimental cholesterol atherosclerosis that administration of trimethylglycinee in a dose of 0.5 g/kg reduces the elevated content of total and ester-bound cholesterol, beta-lipoproteins, total lipids in the blood serum and that of total cholesterol and triglycerides in the liver. Little toxicity and high efficacy of trimethylglycin in experimental atherosclerosis make this compound prospective in the light of its use as an antisclerotic agent.
Tuning the Work‐Function Via Strong Coupling (2013)

The tuning of the molecular material work-function via strong coupling with vacuum electromagnetic fields is demonstrated. Kelvin probe microscopy extracts the surface potential (SP) changes of a photochromic molecular film on plasmonic hole arrays and inside Fabry-Perot cavities. Modulating the optical cavity resonance or the photochromic film effectively tunes the work-function, suggesting a new tool for tailoring material properties.
Large fragment Bst DNA polymerase for whole genome amplification of DNA from formalin-fixed paraffin-embedded tissues (2006)

Large fragment Bst DNA polymerase is suitable for WGA of DNA extracted from FFPE tissues, with an expected maximal representational distortion of threefold. Amplified DNA may be used for the detection of gene copy number changes by quantitative realtime PCR and genome profiling by array CGH.
Enantio-and stereo-selective route to the taxol side chain via asymmetric epoxidation of trans-cinnamyl alcohol and subsequent expoxide ring opening (1994)

The first route to the side chain of Taxol and Taxotere, employing asymmetric epoxidation (AE) of trans-cinnamyl alochol and a new highly regio- and stereo-selective opening to the epoxide ring with MgBr2, is described.
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease (2009)

Invasive fungal infections are a leading cause of mortality among immunocompromised individuals. Treatment is notoriously difficult with the limited armamentarium of antifungal drugs, whose efficacy is compromised by host toxicity, a limited activity spectrum, or the emergence of drug resistance. We previously established that the molecular chaperone Hsp90 enables the emergence and maintenance of fungal drug resistance. For the most prevalent fungal pathogen of humans, Candida albicans, Hsp90 mediates resistance to azoles, which inhibit ergosterol biosynthesis and are the most widely deployed antifungals in the clinic. For the emerging opportunistic pathogen Aspergillus terreus, Hsp90 is required for basal resistance to echinocandins, which inhibit beta(1, 3)-glucan synthesis and are the only new class of antifungals to reach the clinic in decades. Here, we explore the therapeutic potential of Hsp90 inhibitors in fungal disease using a tractable host-model system, larvae of the greater wax moth Galleria mellonella, and a murine model of disseminated disease. Combination therapy with Hsp90 inhibitors that are well tolerated in humans and an azole rescued larvae from lethal C. albicans infections. Combination therapy with an Hsp90 inhibitor and an echinocandin rescued larvae from infections with the most lethal mold, Aspergillus fumigatus. In a murine model of disseminated candidiasis, genetic compromise of C. albicans HSP90 expression enhanced the therapeutic efficacy of an azole. Thus, harnessing Hsp90 provides a much-needed strategy for improving the treatment of fungal disease because it enhances the efficacy of existing antifungals, blocks the emergence of drug resistance, and exerts broad-spectrum activity against diverse fungal pathogens.
Identification of a novel type of alternative splicing of a tyrosine kinase receptor. Juxtamembrane deletion of the c-met protein kinase C serine phosphorylation regulatory site. (1994)

We have detected a novel type of structural variant of the tyrosine kinase receptor for c-met, also known as the hepatocyte growth factor receptor, in mouse tissues. The cDNA of the variant transcript of c-met lacks 141 base pairs, which predicts an in-frame deletion of 47 amino acids in the juxtamembrane region of the cytoplasmic domain. Sequence analysis of genomic DNA containing the c-met locus revealed that the absence of a discrete exon is responsible for this 141-base pair deletion and that alternative splicing leads to production of two forms of transcript. These two forms of transcript are designated as c-metsm (for small) and c-metlg (for large) to distinguish the absence or presence of the 141-base pair segment, respectively. The c-metsm variant is present in adult mouse tissues including kidney, liver, and brain as well as in 9-10-day-old embryos. In all cases, expression of c-metsm was lower than that of the normal transcript, c-metlg. An antiserum against mouse c-Met protein immunoprecipitated corresponding protein forms of approximately 152 and approximately 145 kDa from whole kidney lysate under reducing conditions. The size difference of approximately 7 kDa between these isoforms corresponds to the predicted difference of 47 amino acids. The presence of this shorter variant transcript and its corresponding protein isoform in a variety of normal tissues suggests a physiological role. The deleted region in the cytoplasmic domain of c-metsm contains a sequence motif (S985ARS) for protein kinase C phosphorylation that has recently been shown to play a key role in the down-regulation of hepatocyte growth factor receptor kinase activity. The identification of this novel isoform, c-metsm, demonstrates that a tyrosine kinase receptor can achieve additional diversity by alternative splicing at a key regulatory site in its cytoplasmic domain.
Improving Operational Performance of Active Magnetic Bearings Using Kalman Filter and State Feedback Control (2011)

In this paper, the application of optimal state estimation and optimal state feedback algorithms for real-time active magnetic bearing control is treated. A linear quadratic Gaussian controller, consisting of an extended Kalman filter and an optimal state feedback regulator, is implemented. It is shown that this controller yields improved rotor positioning accuracy, better system dynamics, higher bearing stiffness, and reduced control energy effort compared to the conventionally used proportional-integral-differential control approaches. In addition, a method for compensating unbalance-caused forces and vibrations of the magnetically levitated rotor is presented which is based on the estimation of unknown disturbance forces. All results achieved in this paper are verified by means of measurements.
Method Development for Computer Aided Engineering for Aircraft Conceptual Design (2008)

This thesis presents the work done to implement new computational tools and methods dedicated to aircraft conceptual design sizing and optimization. These tools have been exercised on different aircraft concepts in order to validate them and assess their relevance and applicability to practical cases. First, a geometry construction protocol has been developed. It is indeed essential to have a geometry description that supports the derivation of all discretizations and idealizations used by the different analysis modules (aerodynamics, weights and balance, stability and control, etc.) for which an aircraft concept is evaluated. The geometry should also be intuitive to the user, general enough to describe a wide array of morphologies and suitable for optimization. All these conditions are fulfilled by an appropriate parameterization of the geometry. In addition, a tool named CADac (Computer Aided Design aircraft) has been created in order to produce automatically a closed and consistent CAD solid model of the designs under study. The produced CAD model is easily meshable and therefore high-fidelity Computational Fluid Dynamics (CFD) computations can be performed effortlessly without need for tedious and time-consuming post-CAD geometry repair.Second, an unsteady vortex-lattice method based on TORNADO has been implemented in order to enlarge to scope of flight conditions that can be analyzed. It has been validated satisfactorily for the sudden acceleration of a flat plate as well as for the static and dynamic derivatives of the Saab 105/SK 60.Finally, a methodology has been developed to compute quickly in a semi-empirical way the buffet envelope of new aircraft geometries at the conceptual stage. The parameters that demonstrate functional sensitivity to buffet onset have been identified and their relative effect quantified. The method uses a combination of simple sweep theory and fractional change theory as well as the buffet onset of a seed aircraft or a provided generic buffet onset to estimate the buffet envelope of any target geometry. The method proves to be flexible and robust enough to predict within mainly 5% (and in any case 9%) the buffet onset for a wide variety of aircrafts, from regional turboprop to long-haul wide body or high-speed business jets.This work was done within the 6th European framework project SimSAC (Simulating Stability And Control) whose task is to create a multidisciplinary simulation environment named CEASIOM (Computerized Environment for Aircraft Synthesis and Integrated Optimization Methods), oriented toward stability and control and specially suited for aircraft conceptual design sizing and optimization.