gebhart/patrepeval huggingface dataset:
PERFORMANCE-BASED ASSESSMENT OF FUNCTIONAL LIMITATION AND MUSCLE ENDURANCE: RELIABILITY OF THE ADULT MYOSITIS ASSESSMENT TOOL. (2004)

PURPOSE/HYPOTHESIS: Impairments in muscle strength and endurance are prominent clinical manifestations of myositis. No standardized, domain-specific assessment of functional limitation and muscle endurance has been validated for adults with myositis. The Adult Myositis Assessment Tool (AMAT) is a 13-item performance-based battery developed to assess the functional and muscle endurance capabilities of adults with myositis. The purpose of this study was to determine the intrarater and interrater reliability of the AMAT. NUMBER OF SUBJECTS: The AMAT was administered by a single health professional to 6 subjects with myositis (3 males, 3 females, mean age 53, 11 years). Nineteen raters (13 physical therapists and 6 physicians) scored the 6 AMAT performances. MATERIALS/METHODS: AMAT performances were recorded with digital video. All subjects gave informed consent to allow use of the video images. The raters were instructed in the AMAT grading criteria by viewing a 15-20 minute presentation prior to the first reliability session. The raters then viewed the videotaped performances during 2 separate sessions (19 6 days between scoring sessions) and scored the AMAT for each subject. Reliability of the AMAT tasks and subscales was evaluated with Kappa statistics with Fleiss-Cohen weights (Kw) and intraclass correlation coefficients (ICC [2,1]), respectively. Sampling error was estimated with 95% confidence intervals (95% C.I.). RESULTS: Interrter agreement was acceptable for each AMAT task (Kw = .63-.89) except the sit up (Kw = .16) and supine to prone (Kw = .56) tasks. All AMAT tasks had satisfactory intrarater agreement (Kw = .67-1.00) with the exception of the sit up task (Kw = .57). Intrarater and interrater reliability was acceptable for the AMAT functional subscale, endurance subscale, and total score (ICC [2,1] = .95-.98). The 95% C.I. for the AMAT mean total scores did not exceed 2 points across all subjects (AMAT point range = 0-45). CONCLUSIONS: The AMAT tasks have acceptable interrater and intrarater agreement, but the sit up and supine to prone tasks may require revised grading criteria. The AMAT subscales and total score demonstrate high intrarater and interrater relative reliability. The narrow 95% C.I. of the mean AMAT total scores further support the reliability and clinical utility of the battery. CLINICAL RELEVANCE: The AMAT is a reliable, domain-specific, assessment of functional limitation and muscle endurance for adult subjects with myositis. Results of this study suggest that health professionals may reliably score the AMAT following a single training session.
Microphthalmia transcription factor as a molecular marker for circulating tumor cell detection in blood of melanoma patients. (2006)

Mitf detection in blood can indicate subclinical metastatic disease and predict treatment outcome in melanoma patients.
The LLN On-demand Ad hoc Distance-vector Routing Protocol - Next Generation (LOADng) (2011)

This document describes the LLN Ad hoc On-Demand (LOAD) distance vector routing protocol - Next Generation, a reactive routing protocol intended for use in Low power Lossy Networks (LLN). The protocol is derived from AODV and extended for use in LLNs.
Use of photochemically induced crosslinking as a conformational probe of the tertiary structure of certain regions in transfer ribonucleic acid (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of photochemically induced crosslinking as a conformational probe of the tertiary structure of certain regions in transfer ribonucleic acidJames Ofengand and Joan BierbaumCite this: Biochemistry 1973, 12, 10, 1977–1984Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/bi00734a022https://doi.org/10.1021/bi00734a022research-articleACS PublicationsRequest reuse permissionsArticle Views18Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization of a <i>Bifidobacterium longum</i> BORI Dipeptidase Belonging to the U34 Family (2007)

A dipeptidase was purified from a cell extract of Bifidobacterium longum BORI by ammonium sulfate precipitation and chromatography on DEAE-cellulose and Q-Sepharose columns. The purified dipeptidase had a molecular mass of about 49 kDa and was optimally active at pH 8.0 and 50 degrees C. The enzyme was a strict dipeptidase, being capable of hydrolyzing a range of dipeptides but not tri- and tetrapeptides, p-nitroanilide derivatives of amino acids, or N- or C-terminus-blocked dipeptides. A search of the amino acid sequence of an internal tryptic fragment against protein sequences deduced from the total genome sequence of B. longum NCC2705 revealed that it was identical to an internal sequence of the dipeptidase gene (pepD), which comprised 1,602 nucleotides encoding 533 amino acids with a molecular mass of 60 kDa, and thereby differed considerably from the 49-kDa mass of the purified dipeptidase. To understand this discrepancy, pepD was cloned into an Escherichia coli expression vector (pBAD-TOPO derivative) to generate the recombinant plasmids pBAD-pepD and pBAD-pepD-His (note that His in the plasmid designation stands for a polyhistidine coding region). Both plasmids were successfully expressed in E. coli, and the recombinant protein PepD-His was purified using nickel-chelating affinity chromatography and reconfirmed by internal amino acid sequencing. The PepD sequence was highly homologous to those of the U34 family of peptidases, suggesting that the B. longum BORI dipeptidase is a type of cysteine-type N-terminal nucleophile hydrolase and has a beta-hairpin motif similar to that of penicillin V acylase, which is activated by autoproteolytic processing.
A Simple Method of Separating Metallic and Semiconducting Single-Walled Carbon Nanotubes Based on Molecular Charge Transfer (2010)

Interaction of as-prepared single-walled carbon nanotubes (SWNTs), containing a mixture of metallic and semiconducting species with the potassium salt of coronene tetracarboxylic acid, I, in an aqueous medium provides a simple method of separating semiconducting and metallic species. The metallic nanotubes precipitate out on interaction with I while the semiconducting nanotubes remain in solution. The method avoids centrifugation and is amenable for large-scale separation and can be used as a routine laboratory procedure. Interestingly, interaction with strong electron acceptor molecules brings about metal-semiconductor transitions in SWNTs.
Low‐Cost Molybdenum Carbide and Tungsten Carbide Counter Electrodes for Dye‐Sensitized Solar Cells (2011)

Sunny prospects for renewable energy: Molybdenum and tungsten carbides embedded in ordered nanomesoporous carbon materials as well as Mo2C and WC are proposed as alternatives to the expensive platinum counter electrode (Pt CE). The preparation of the CEs was optimized, and the dye-sensitized solar cells (DSCs; see picture) equipped with these CEs show a higher energy conversion efficiency than those devices with a Pt CE.
Endocardial ventricular pulsed field ablation: a proof-of-concept preclinical evaluation (2019)

We demonstrate that endocardial PFA can be focally delivered using this prototype catheter to create homogeneous, myocardium-specific lesions.
Functionalized Single Wall Carbon Nanotubes Treated with Pyrrole for Electrochemical Supercapacitor Membranes (2005)

Supercapacitor electrodes based on pyrrole treated-functionalized single wall carbon nanotubes (SWNTs) were developed. High values of capacitance (350 F/g), power density (4.8 kW/kg), and energy density (3.3 kJ/kg) were obtained in 6 M KOH, and the capacitance is almost 7 times that of the control buckypaper. Specific capacitance of these materials has a strong dependence on the macropore surface area. The double layer capacity of pyrrole treated-functionalized SWNT electrodes is 154 μF/cm2 based on the BET model, and even higher based on the DFT model.
On‐line coupling of size‐exclusion chromatography and capillary zone electrophoresis <b><i>via</i></b> a reversed‐phase C18 trapping column for the determination of peptides in biological samples (2003)

Since biologically active peptides usually exhibit their effects in low concentrations, the development of sensitive analytical methods has become a challenge. In this paper, a multidimensional system is presented, consisting of a size-exclusion chromatographic (SEC) separation followed by a trapping procedure on a 4 mm x 3 mm ID reversed-phase C18 (RP18) column with subsequent elution of the trapped fraction and separation by capillary zone electrophoresis (CZE). The system has been tested with mixtures of six enkephalins and albumin, mimicking biological matrices such as plasma and cerebrospinal fluid. After separation of albumin from the enkephalins in the SEC dimension a heart-cut of 200 micro L, containing the enkephalin peak, is taken, concentrated on the RP18 microcolumn and, after elution with a 20 micro L plug of 80% acetonitrile, electrokinetically injected into the CZE system, where stacking and separation is achieved. While validation shows generally good linearity and reproducibility, the quantitation limit with UV detection is acceptable (2.5 micro g/ mL with an injection volume of 50 micro L).
Surfactant Ligand Removal and Rational Fabrication of Inorganically Connected Quantum Dots (2011)

A novel method is reported to create inorganically connected nanocrystal (NC) assemblies for both II-VI and IV-VI semiconductors by removing surfactant ligands using (NH4)2S. This surface modification process differs from ligand exchange methods in that no new surfactant ligands are introduced and the post-treated NC surfaces are nearly bare. The detailed mechanism study shows that the high reactivity between (NH4)2S and metal-surfactant ligand complexes enables the complete removal of surfactant ligands in seconds and converts the NC metal-rich shells into metal sulfides. The post-treated NCs are connected through metal-sulfide bonding and form a larger NCs film assembly, while still maintaining quantum confinement. Such "connected but confined" NC assemblies are promising new materials for electronic and optoelectronic devices.
Crystal structure of 4-amino-1-arsenoso-benzene dihydrate, H<sub>2</sub>NC<sub>6</sub>H<sub>4</sub>As(OH)<sub>2</sub>(H<sub>2</sub>O) (1995)

Article Crystal structure of 4-amino-1-arsenoso-benzene dihydrate, H2NC6H4As(OH)2(H2O) was published on August 1, 1995 in the journal Zeitschrift für Kristallographie - Crystalline Materials (volume 210, issue 8).
[Value of liver histology in diagnosis of chronic hepatopathies]. (1998)

The importance of a liver biopsy is summarized as follows: 1. A diagnostic liver biopsy may be helpful in otherwise unexplained liver disease, especially in cases with controversial or unexplicable patterns of laboratory findings or in chronic hepatitis without positive serological markers. 2. Liver histology is necessary for the assessment of the necroinflammatory activity of chronic hepatitis in order to decide on an eventual therapy. Liver biopsy is an important tool as well for the evaluation of liver transplantation in the end stage of several liver diseases as for the diagnosis of transplant-complications. 3. Follow-up biopsies are necessary for supervision of therapy of chronic hepatitis. Histology is the only reliable method for assessment of necroinflammatory activity.
Elastic CGRAs (2013)

Vital technology trends such as voltage scaling and homogeneous multicore scaling have reached their limits and architects turn to alternate computing paradigms, such as heterogeneous and domain-specialized solutions. Coarse-Grain Reconfigurable Arrays (CGRAs) promise the performance of massively spatial computing while offering interesting trade-offs of flexibility versus energy efficiency. Yet, configuring and scheduling execution for CGRAs generally runs into the classic difficulties that have hampered Very-Long Instruction Word (VLIW) architectures: efficient schedules are difficult to generate, especially for applications with complex control flow and data structures, and they are inherently static - thus, in adapted to variable-latency components (such as the read ports of caches). Over the years, VLIWs have been relegated to important but specific application domains where such issues are more under the control of the designers; similarly, statically-scheduled CGRAs may prove inadequate for future general-purpose computing systems. In this paper, we introduce Elastic CGRAs, the superscalar processors of computing fabrics: no complex schedule needs to be computed at configuration time, and the operations execute dynamically in the CGRA when data are ready, thus exploiting the data parallelism that an application offers. We designed, down to a manufacturable layout, a simple CGRA where we demonstrated and optimized our elastic control circuitry. We also built a complete compilation toolchain that transforms arbitrary C code in a configuration for the array. The area overhead (26.2%), critical path overhead (8.2%) and energy overhead (53.6%) of Elastic CGRAs over non-elastic CGRAs are significantly lower than the overhead of superscalar processors over VLIWs, while providing the same benefits. At such moderate costs, elasticity may prove to be one of the key enablers to make the adoption of CGRAs widespread.
Alcohol‐Induced Euphoria Enhanced by Disulfiram and Calcium Carbimide (1983)

In a double-blind study, subjects were treated with either disulfiram or calcium carbimide, inhibitors of acetaldehyde elimination, prior to consumption of low doses of alcohol. Self-rating scales, individual interviews, and observations by independent judges revealed that experimental subjects manifested enhanced changes in mood and euphoria compared to placebo control subjects.
MASS TRANSFER CHARACTERISTICS OF HOLLOW FIBER ULTRAFILTRATION OF SOY PROTEIN SYSTEMS (1977)

ABSTRACT Mass transfer characteristics and the applicability of theoretical transport models in ultrafilitration were evaluated in a pilot‐scale hollow fiber system processing soybean water extracts. Permeate flux was found to increase linearly with transmembrane pressure and then reach an asymptotic value. Substantial deviations from the pure water permeation line and marked hysteresis effects were also observed, indicative of concentration polarization and additional hydrodynamic resistance at the membrane surface. Pressure‐independence occurred at lower pressures with lower Reynolds Numbers (Re) and higher Schmidt Numbers (Sc). Flow rate and temperature significantly affected flux in the totally polarized region. The exponent in the flux‐Reα relationship varied from 0.6 at 20°C to 0.32 at 50°C. Theoretical laminar flow mass transfer models were found to predict Sherwood Numbers (Sh) and flux lower than experimental values. The correlation that fit the data best was Sh = 0.181 (Re). 47 (Sc). 33
Distribution of GLP‐1 Binding Sites in the Rat Brain: Evidence that Exendin‐4 is a Ligand of Brain GLP‐1 Binding Sites (1995)

The distribution and biochemical properties of glucagon-like peptide (GLP)-1(7-36) amide (GLP-1) binding sites in the rat brain were investigated. By receptor autoradiography of tissue sections, the highest densities of [125I]GLP-1 binding sites were identified in the lateral septum, the subfornical organ (SFO), the thalamus, the hypothalamus, the interpenduncular nucleus, the posterodorsal tegmental nucleus, the area postrema (AP), the inferior olive and the nucleus of the solitary tract (NTS). Binding studies with [125I][Tyr39] exendin-4, a GLP-1 receptor agonist, showed an identical distribution pattern of binding sites. Binding specificity and affinity was investigated using sections of the brainstem containing the NTS. Binding of [125I]GLP-1 to the NTS was inhibited concentration-dependently by unlabelled GLP-1 and [Tyr39]exendin-4 with KI values of 3.5 and 9.4 nM respectively. Cross-linking of hypothalamic membranes with [125I]GLP-1 or [125I][Tyr39]exendin-4 identified a single ligand-binding protein complex with a molecular mass of 63,000 Da. The fact that no GLP-1 binding sites were detected in the cortex but that they were detected in the phylogenetically oldest parts of the brain emphasizes that GLP-1 may be involved in the regulation of vital functions. In conclusion, the biochemical data support the idea that the central GLP-1 receptor resembles the peripheral GLP-1 receptor. Furthermore, the presence of GLP-1 binding sites in the circumventricular organs suggests that these may be receptors which act as the target for both peripheral blood-borne GLP-1 and GLP-1 in the nervous system.
Automatic text block separation in document images (2006)

Separation of printed text blocks from the non-text areas, containing signatures, handwritten text, logos and other such symbols, is a necessary first step for an OCR involving printed text recognition. In the present work, we compare the efficacy of some feature-classifier combinations to carry out this separation task. We have selected length-normalized horizontal projection profile (HPP) as the starting point of such a separation task. This is with the assumption that the printed text blocks contain lines of text which generate HPP's with some regularity. Such an assumption is demonstrated to be valid. Our features are the HPP and its two transformed versions, namely, eigen and Fisher profiles. Four well known classifiers, namely, nearest neighbor, linear discriminant function, SVM's and artificial neural networks have been considered and efficiency of the combination of these classifiers with the above features is compared. A sequential floating feature selection technique has been adopted to enhance the efficiency of this separation task. The results give an average accuracy of about 96%.
MSH1-Induced Non-Genetic Variation Provides a Source of Phenotypic Diversity in Sorghum bicolor (2014)

MutS Homolog 1 (MSH1) encodes a plant-specific protein that functions in mitochondria and chloroplasts. We showed previously that disruption or suppression of the MSH1 gene results in a process of developmental reprogramming that is heritable and non-genetic in subsequent generations. In Arabidopsis, this developmental reprogramming process is accompanied by striking changes in gene expression of organellar and stress response genes. This developmentally reprogrammed state, when used in crossing, results in a range of variation for plant growth potential. Here we investigate the implications of MSH1 modulation in a crop species. We found that MSH1-mediated phenotypic variation in Sorghum bicolor is heritable and potentially valuable for crop breeding. We observed phenotypic variation for grain yield, plant height, flowering time, panicle architecture, and above-ground biomass. Focusing on grain yield and plant height, we found some lines that appeared to respond to selection. Based on amenability of this system to implementation in a range of crops, and the scope of phenotypic variation that is derived, our results suggest that MSH1 suppression provides a novel approach for breeding in crops.
Requirement of thymus-derived theta-positive lymphocytes for rejection of DNA virus (SV 40) tumors in mice. (1974)

The nature of lymphocytes capable of inhibiting the growth of syngeneic papovavirus SV40 tumor cells in BALB/c was investigated by the tumor cell neutralization assay. Treatment of immune lymphocytes with anti-C3H (θ) AKR sera in the presence of complement eliminated the lymphocytes capable of inhibiting tumor cells in vivo. Treatment of immune lymphocytes with normal AKR sera and complement had no effect. Lymphocytes filtered through nylon wool column, a procedure known to remove B lymphocytes, retained their capacity to inhibit tumor cells in vivo. Thymectomized, irradiated, and reconstituted mice failed to develop lymphocytes sensitized to SV40 tumor-specific transplantation antigen (TSTA). These results suggest that cellular immune response to SV40 tumor cells in syngeneic mice is mediated by θ-positive thymus-derived lymphocytes.
A Contiguous Network of Dendritic Antigen-Presenting Cells within the Respiratory Epithelium (1990)

This study utilises a simple technique to section airway epithelium in a plane parallel to the basement membrane, thus providing a unique plan view of the intra-epithelial cell populations. Immunoperoxidase staining of these tissue sections for class II major histocompatibility complex Ia antigen reveals a virtually contiguous network of Ia-positive dendritic cells (DC) within the epithelium. These DC are shown to be capable of binding inhaled antigens in vivo in a form suitable for presentation to T cells. The strategic location of these cells and the fact that they account for virtually all staining in the airway epithelium during the steady state is convincing evidence that the DC network functions as the 'first line of defence' in surveillance for inhaled antigens and further suggests a major role for the intra-epithelial DC in allergic and infectious disease(s) in the respiratory tract.
Activation of Natural Killer‐Like YT‐INDY Cells by Oligodeoxynucleotides and Binding by Homologous Pattern Recognition Proteins (2005)

The present study was designed to examine the binding and signalling effects of single base and CpG dinucleotide phosphodiester (Po) oligodeoxynucleotides (ODN) on the human natural killer (NK)-like cell line (YT-INDY). Single base Po ODN composed of 20-mers of guanosine (dG20), adenosine (dA20), cytosine (dC20) or thymidine (dT20) as well as 'conventional' Po CpG ODN were examined for their ability to bind and activate YT-INDY cells. Binding by dG20 and CpG ODN to YT-INDY cells was saturable and specific. dG20 binding was competitively inhibited by homologous dG20 and heterologous CpG ODN but not by dC20 and dA20. Two different YT-INDY membrane proteins (18 and 29 kDa) were identified by ligand (Southwestern) blotting with biotinylated dG20 and CpG. The specificity of the ODN-binding protein(s) was further confirmed by ODN depletion experiments using a teleost recombinant protein orthologue [nonspecific cytotoxic cells (NCC) cationic antimicrobial protein-1 (ncamp-1)] known to bind CpG and dG20. Cell proliferation and activation studies showed that dG20 and CpG treatment of YT-INDY cells induced cellular DNA synthesis (i.e. G1 to S-phase conversion). This signalling function was accompanied in dG20-treated cells by proliferation 10 h posttreatment. Both dG20 and CpG ODN binding induced a calcium flux in YT-INDY cells within seconds of treatment. These experiments demonstrated that Po single base dG20 and CpG ODN bind to a (potential) new class of cell-surface proteins that mediate the activation of YT-INDY cells.
Probabilistic Analysis of Packing and Partitioning Algorithms (1991)

Analysis Techniques. Matching Problems. Scheduling and Partitioning. Bin Packing: The Optimum Solution. Bin Packing: Heuristics. Packings in Two Dimensions. References. Index.