gebhart/patrepeval huggingface dataset:
Preventing and controlling dyskinesia in Parkinson's disease-A view of current knowledge and future opportunities (2008)

Dyskinesia affects approximately 30 to 40% of patients with Parkinson's disease but treatment options for the prevention of dyskinesia induction and for the suppression of established dyskinesia are limited. This situation is made more difficult by a poor understanding of the pathphysiology of the processes underlying both the priming for dyskinesia and the manifestations of involuntary movements. Loss of tonic stimulation of striatal dopamine receptors in PD and its replacement by pulsatile dopaminergic stimulation using short acting drugs has been proposed as leading to the abnormalities that cause dyskinesia induction. As a consequence, the concept of continuous dopaminergic stimulation (CDS) was introduced to explain why longer acting dopamine agonists do not produce the same intensity of dyskinesia. Key to these ideas has been the use of both 6-OHDA lesioned rodent models of PD and, in particular MPTP-treated primates. Comparison of the ability to induce dyskinesia of the same dopamine agonists given by pulsatile or continuous administration or more constant administration of Levodopa (L-dopa) has shown that constant drug delivery (CDD) dramatically reduces dyskinesia induction. Similar conclusions have been reached from clinical investigations in PD. Recent studies in MPTP-treated primates have also suggested that switching from pulsatile drug delivery to CDD can be utilized to inhibit dyskinesia expression. However, CDS does explain some important features of dyskinesia induction in PD but it may not apply to early PD when remaining dopaminergic neurones buffer against pulsatile stimulation. In addition, CDS may not apply when comparing between drug classes and it appears that it is CDD which is more important in regulating therapeutic efficacy. Recently, studies in MPTP-treated primates have suggested that a range of nondopaminerigic drugs might be useful in suppressing dyskinesia. These have included 5-HT-1A agonists and alpha-2 adrenergic antagonists and a variety of other molecular entities. Unfortunately, these findings are not always reproducible in the same models and do not translate into clinically useful effects. Preclinical studies have suggested a number of directions that might be utilized to prevent dyskinesia in PD. However, much of what is proposed is empirically-based and we still do not have a good understanding of why dyskinesia appears, why it persists or how to bring the movements under control. Certainly, the use of CDD can reduce dyskinesia intensity but other factors also influence its appearance and it is these that we need to study at the preclinical level if effective therapies are to be developed.
A density management diagram for teak plantations ofKerala in peninsular India. For. Ecol. and Management (1995)

A density management diagram was constructed using stand inventory data from 193 teak (Tectona grandis L.f) plantations in Western Ghats of peninsular India. The diagram's utility in predicting and displaying the consequences of stand density manipulations is illustrated with two alternative density management regimes.
Disease-Free Survival after Hepatic Resection in Hepatocellular Carcinoma Patients: A Prediction Approach Using Artificial Neural Network (2012)

The ANN model outperformed the LR and DT models in terms of prediction accuracy. This study demonstrated the feasibility of using ANNs in medical decision support systems for predicting disease-free survival based on clinical databases in HCC patients who have received hepatic resection.
Measurement based behavioral modeling of impedance dependent transistor non-linearity (2002)

A novel modeling approach is presented that utilizes load pull measurements at a number of known terminations and fits a data based model of the measured parameter as a function of the fundamental and harmonic termination. The techniques utilizes a solid-state, single load pull tuner without a multiplexer or harmonic loops. It creates a general equation of device performance with predictive abilities. This paper presents the measurement system, the modeling approach, and the measured and predicted results.
Effect of Elevated Temperature on Ceramic Ultrafiltration of Colloidal Suspensions (2014)

High-temperature wastewaters and process waters in many industries have been a concern, compromising the integrity of polymeric membranes in filtration processes or requiring the temperature to be lowered for further treatments. Filtration processes employing ceramic membranes, however, can treat high temperature water owing to the inherent thermal resistance of ceramic materials, and may benefit from increases in permeate flux attributable to decreases in water viscosity at higher temperatures. In this study, the performance of a ceramic ultrafiltration membrane was evaluated for the filtration of feed solutions containing colloidal silica at temperatures between 25 and 90°C, the range encountered in various industries. Results indicated the net benefit of increasing permeate production at elevated temperatures, with a nearly 90% increase in steady-state flux from 25 to 90°C. However, this increase was lower than that observed for pure water filtration, in which the flux increase with increasing temperature was entirely attributable to viscosity reduction. Resistance-in-series model analysis and cake property characterization suggested that total fouling resistance increased as temperature increased, with physically removable cake formation as the dominant fouling mechanism.
Hydrocarbon Adsorption in the Flexible Metal Organic Frameworks MIL-53(Al, Cr) (2008)

A general study of the adsorption of n-alkanes in the flexible metal organic framework (MOF) MIL-53 is presented. The roles of the length of the alkyl chain (n = 1-9), the nature of the metal (Al, Cr), and temperature were investigated. The shape of the adsorption curves is driven by the alkyl chain length of the n-alkanes. While traditional type-I isotherms are observed for short alkanes (n = 1, 2), adsorbates with longer chains induce clear substeps in the isotherm curves whose positions depend on the chain length. Such substeps are due to a breathing phenomenon, as proven by ex situ X-ray diffraction analysis. They strongly depend on the amount of adsorbate in the pores and on the nature of the metal (Al, Cr), which, for a given alkane, leads to a strong change in the substep positions despite the similar characteristics of the two metals. The adsorption kinetics are highly sensitive to small variations in temperature. Their detailed analysis in different regions of the isotherms shows in some cases the existence of distinct diffusion regimes and/or conformations within the flexible phases.
Towards an expanded and integrated linkage map of cucumber (<i>Cucumis sativus</i>L.) (2001)

Linkage maps in cucumber (Cucumis sativus var. sativus L.) have been constructed using morphological traits, isozymes, restriction fragment length polymorphisms (RFLPs), and random amplified polymorphic DNAs (RAPDs). The lack of polymorphism in cucumber has led to the construction of relatively unsaturated maps (13- to 80-point). We have added amplified fragment length polymorphism (AFLP) markers to existing narrow-based (within C. sativus) and wide-based (C. sativus × C. sativus var. hardwickii) maps. JoinMap v. 2.0 was used to construct maps and to join these with historical maps from several previous studies. Our narrow- and wide-based merged maps contain 255 and 197 markers, respectively, including morphological traits, disease resistance loci, isozymes, RFLPs, RAPDs, and AFLPs. Condensation of total map distance occurred in merged maps compared to historic maps using many of the same markers. This phenomenon is most likely due to differences in map construction algorithms. The merged maps represent the best fit of the data used and are an important first step towards the construction of a comprehensive linkage map for cucumber. Identification of additional anchor markers between the narrow- and wide-based maps presented here may allow their future integration into a unified model.Key words: map merging, JoinMap, cucumber, AFLP.
Statistically-optimum dynamic server assignment in systems with interfering servers (1972)

In a mobile radio system which uses many base stations to provide radio service over a large geographical area, and which has a stored-program processor to assign radio channels to base stations in real time, the queueing characteristics of the overall system are strongly dependent on the processor algorithms which are used. Three algorithms, which are in a certain minimax sense statistically optimum, are described below. The procedures are quite general, and may be usefully applied to any system which employs many servers, the use of some combinations of which is not allowed.
123 EXERCISE AND IMMUNOLOGY (1993)

Nash, M. S.; Nieman, D. C. FACSM; Pederson, B. K.; Davis, J. M. FACSM; Hoffman-Goetz, L.; Mackinnon, L. Traeger FACSM Author Information
A survey of Direction of Arrival estimation techniques and implementation of channel estimation based on SCME (2015)

In this paper, basics of Direction of Arrival (DOA) estimation techniques were reviewed along with simulated results. It justifies the pros and cons of each technique. The purposes of using smart antenna system in this paper are regarded with the respect of DOA estimation, Path Delays estimation, and accurate channel estimation between a transmitter and an array of receivers. Considering the uplink transmission system, a source antenna transmits a signal and a group of antennas placed uniformly receives the signal. Then the target was to perform the common DOA estimation techniques to analyze the source signal. Since the Long Term Evolution (LTE) is the currently available standard, this model was used to estimate the channel with the help of a 2D harmonic model. Spatial Channel Model was considered for the simulation and finally, a uniform rectangular array model is compared with a multipath channel equation to estimate the channel.
Altered microRNA expression in human heart disease (2007)

MicroRNAs are recently discovered regulators of gene expression and are becoming increasingly recognized as important regulators of heart function. Genome-wide profiling of microRNAs in human heart failure has not been reported previously. We measured expression of 428 microRNAs in 67 human left ventricular samples belonging to control (n = 10), ischemic cardiomyopathy (ICM, n = 19), dilated cardiomyopathy (DCM, n = 25), or aortic stenosis (AS, n = 13) diagnostic groups. miRNA expression between disease and control groups was compared by ANOVA with Dunnett's post hoc test. We controlled for multiple testing by estimating the false discovery rate. Out of 428 microRNAs measured, 87 were confidently detected; 43 were differentially expressed in at least one disease group. In supervised clustering, microRNA expression profiles correctly grouped samples by their clinical diagnosis, indicating that microRNA expression profiles are distinct between diagnostic groups. This was further supported by class prediction approaches, in which the class (control, ICM, DCM, AS) predicted by a microRNA-based classifier matched the clinical diagnosis 69% of the time (P < 0.001). These data show that expression of many microRNAs is altered in heart disease and that different types of heart disease are associated with distinct changes in microRNA expression. These data will guide further studies of the contribution of microRNAs to heart disease pathogenesis.
Synthesis of dl-deethylibogamine (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of dl-deethylibogamineRobert L. Augustine and William G. PiersonCite this: J. Org. Chem. 1969, 34, 4, 1070–1075Publication Date (Print):April 1, 1969Publication History Published online1 May 2002Published inissue 1 April 1969https://pubs.acs.org/doi/10.1021/jo01256a065https://doi.org/10.1021/jo01256a065research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Novel Immunosuppressive Agent Mycophenolate Mofetil Markedly Potentiates the Antiherpesvirus Activities of Acyclovir, Ganciclovir, and Penciclovir In Vitro and In Vivo (1998)

The immunosuppressive agent mycophenolate mofetil (MMF) has been approved for use in kidney transplant recipients and may thus be used concomitantly for the treatment of intercurrent herpesvirus infections with drugs such as acyclovir (ACV), ganciclovir (GCV), and penciclovir (PCV). We found that MMF and its parent compound mycophenolic acid (at concentrations that are attainable in plasma) strongly potentiate the antiherpesvirus (herpes simplex virus [HSV] type 1 [HSV-1], HSV-2, thymidine kinase-deficient [TK-] HSV-1, both wild-type and TK- varicella-zoster virus, and human cytomegalovirus) activities of ACV, PCV, and GCV (up to 350-fold increases in their activities). The mechanism of potentiation was found to reside in the depletion of endogenous dGTP pools, which favored the inhibitory effect of the triphosphate of ACV, GCV, or PCV on the viral DNA polymerase. The combination of topically applied 5% MMF with 0.1% ACV strongly protected against HSV-1-induced cutaneous lesions in hairless mice, whereas therapy with either compound used singly had no protective effect. Interestingly, the combination of topically applied 5% MMF with 5% ACV was also highly effective in protecting against TK- HSV-2-induced cutaneous lesions (that were refractory to ACV treatment) in athymic nude mice. Topical therapy with MMF was very well tolerated, and no signs of irritation were observed. When given perorally at 200 mg/kg of body weight/day, MMF potentiated to some extent the growth retardation induced by GCV in young NMRI mice. These observations may have clinical implications (i) for those transplant recipients who receive both MMF and either ACV, GCV, or PCV and (ii) for the treatment of ACV-resistant mucocutaneous HSV infections.
Series for the Wave Function of a Radiating Dipole at the Earth's Surface (1937)

In This Paper Three Series Expansions Are Derived For The Wave Function of A Vertical Dipole Placed At The Surface of A Plane Earth. Two Convergent Series And One Asymptotic Series Are Obtained. A Remainder Term For The Latter Series Is Given Which Enables One To Set An Upper Limit To The Amount of Error Obtained By Stopping At Any Particular Stage In The Series.
A Single-Inductor Switching DC–DC Converter With Five Outputs and Ordered Power-Distributive Control (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> An integrated five-output single-inductor multiple-output dc-dc converter with ordered power-distributive control (OPDC) in a 0.5 $\mu\hbox{m}$ Bi-CMOS process is presented. The converter has four main positive boost outputs programmable from $+$5 V to $+$12 V and one dependent negative output ranged from $-$12 V to $-$5 V. A maximum efficiency of 80.8% is achieved at a total output power of 450 mW, with a switching frequency of 700 kHz. The performance of the converter as a commercial product is successfully verified with a new control method and proposed circuits, including a full-waveform inductor-current sensing circuit, a variation-free frequency generator, and an in-rush-current-free soft-start method. With simplicity, flexibility, and reliability, the design enables shorter time-to-market in future extensions with more outputs and different operation requirements. </para>
Thermal behavior and electrical conductivity of poly(vinyl pyridine)/copper complexes (2000)

Poly(2-vinyl pyridine) [P2VP] and poly(4-vinyl pyridine) [P4VP]/copper iodide binary mixtures were studied by differential scanning calorimetry (DSC) in order to investigate the phase behavior of the blends at microscopic level. The glass transition temperature (Tg) of the P2VP/copper iodide binary mixtures as compared with pure polymer increased by 80°C when the amount of Cu(I) in the blend was increased up to 40/60 wt/wt monomer/inorganic salt composition for P2VP. For P4VP, the Tg increased by 40°C in an 80/20 wt/wt decreasing by 10°C at 60/40 wt/wt. Fourier transform infrared (FTIR) and Raman spectroscopy provided molecular-level data, suggesting that copper coordinates with pyridine rings via nitrogen ion pairs in a metal-ligand bonding. Conductivity measurements were carried out at different temperatures and compositions, and upon increasing the amount of copper iodine in the blends, the conductivity increased drastically. © 2000 John Wiley & Sons, Inc. Adv Polym Techn 19: 113–119, 2000
PROPHYLACTIC VS. SYMPTOMATIC THIRD MOLAR REMOVAL: EFFECTS ON PATIENT POSTOPERATIVE MORBIDITY (2021)

The present study aimed to assess differences in postoperative morbidity between prophylactic and symptomatic third molar removals, and to assess the effect of age on the recovery of the patient. Patients admitted for third molar removal were prospectively followed up four times during treatment in context of the M3BE study. Data were collected through pre-, peri and postoperative surveys (days 3 and 10). Uni- and multivariable logistic regression was used to assess the probability of postoperative symptoms of discomfort on day 3 and day 10 according to several patient- and surgery-related predictive factors (age, gender, indication for removal, method of extraction, anesthesia and number of extracted maxillary and/or mandibular third molars). In total, 6010 patients with a mean age of 25.2 (± 11.2) underwent 6347 surgeries to have 15,357 third molars removed. Frequently observed symptoms of postoperative discomfort were pain, trismus and swelling, all of which were transient in nature with steep decreases from postoperative days 3 to 10. Increasing age was associated with an enhanced risk of persistent pain, trismus and swelling and a significantly higher risk of iatrogenic injury to the inferior alveolar nerve. Symptomatic indications for removal were more common in patients over age 25 years, but these pre-existing pathologies did not compromise the postoperative recovery process. Other factors related to postoperative morbidity were female gender, intraoperative osteotomy and the number of extractions. The results of this study suggest that there are convincing patient- and surgery-related factors that favor timely third molar removal, preferably before the age of 25, especially in order to avoid persistent morbidity and nerve complications.
Highly Stretchable Thermoset Fibers and Nonwovens Using Thiol–ene Photopolymerization (2014)

In this report, we describe the preparation and characterization of a new class of thermoset fibers with high elongation and elastic recovery. Integrating UV-activated thiol-ene photopolymerization and electrospinning, we demonstrate an environmentally friendly single step approach to convert small monomeric precursor molecules into highly elastic fibers and nonwoven mats. The fibers were derived by in situ photopolymerization of a trifunctional vinyl ether monomer and a tetrafunctional thiol. Although thermosets often offer good chemical and thermal stability, these fibers also have a high average elongation at break of 62%. The elastomeric nature of these vinyl-ether based fibers can be partly attributed to their subambient Tg and partly to the cross-link density, monomer structure, and resulting network homogeneity. Nonwoven mats of these fibers were also stretchable and exhibited a much higher elongation at break of about 85%. These thermoset stretchable fibers could have potential applications as textile, biomedical, hot chemical filtration, and composite materials.
Carbohydrate-binding protein 35. II. Analysis of the interaction of the recombinant polypeptide with saccharides (1993)

The carbohydrate binding specificity of recombinant carbohydrate-binding protein 35 (rCBP35) has been investigated by quantitative precipitation using a series of glycoproteins and carbohydrate-protein conjugates and by inhibition of precipitation using well defined carbohydrate haptens. Synthetic glycoconjugates and glycoproteins containing terminal nonreducing galactosyl units in beta-linkage were capable of forming a precipitate with rCBP35. If the glycoprotein or glycoconjugate contained terminal Neu5Ac, or galactose in alpha-linkage, precipitate formation was not observed. We also found that murine laminin, which contains polylactosamine structures, reacted more strongly than did bovine fetuin. Using carbohydrate-bovine serum albumin (BSA) glycoconjugates, we found that the tetrasaccharide Gal beta 1, 4GlcNAc beta 1, 3Gal beta 1,4-GlcNAc-BSA reacted more strongly than the disaccharide Gal beta 1, 4GlcNAc-BSA conjugate, suggesting that the binding site accommodates carbohydrate ligands greater in size than a disaccharide. Equilibrium dialysis experiments using [3H]lactose showed that rCBP35 binds 1 mol (n = 0.84) of lactose/30,000 g atoms of protein, with an affinity constant of 2.07 x 10(4) M-1. The binding site on the polypeptide appears to contain four subsites that recognize the sequence Gal beta 1,4GlcNAc beta 1, Gal beta 1,X-. All disaccharides tested that contain a nonreducing beta-galactosyl unit behaved as inhibitors of precipitation at approximately the same concentration, suggesting that the reducing position of the tetrasaccharide does not play an important role in the specific binding to the fourth subsite. The reducing sugar may serve to hold the saccharide in a tunnel like binding pocket since methyl-beta-D-galactoside itself is an extremely poor inhibitor.
Charge, Potential, and Phase Stability of Layered Li(Ni[sub 0.5]Mn[sub 0.5])O[sub 2] (2002)

materials have recently shown promise as high capacity stable electrodes for advanced rechargeable lithium batteries. Using first principles quantum mechanical energy computations we demonstrate that the stability of these materials is due to the particular valence distribution on the transition metals in this material. Spin density calculations indicate that the Mn ion has oxidation state independently of the Li content in the material, while Ni is oxidized from to upon removing Li. The high insertion voltage for the can be partly attributed to the change in Mn-Ni interaction upon Li cycling. © 2002 The Electrochemical Society. All rights reserved.
Disposition of disodium cromoglycate administered in three particle sizes. (1975)

1 Disodium cromoglycate (DSCG) was administered in three particle sizes to five human subjects. 2 Urinary excretion of DSCG, as a proportion of the dose, was highest following small particles; the lower values recorded following intermediate-sized and large particles were similar. 3 DSCG deposited in the mouth was highest following large particles; the lower values recorded following intermediate-sized and small particles were similar. 4 The data were examined in relation to the recent observation that the protective effect of small particles of DSCG is dramatically superior to that of large particles.