gebhart/patrepeval huggingface dataset:
Apolipoprotein E Is Required for Cell Proliferation and Survival in Ovarian Cancer (2005)

Apolipoprotein E (ApoE) has been recently identified as a potential tumor-associated marker in ovarian cancer by serial analysis of gene expression. ApoE has long been known to play a key role in lipid transport, and its specific isoforms may participate in atherosclerogenesis. However, its role in human cancer is not known. In this study, apoE expression was frequently detected in ovarian serous carcinomas, the most common and lethal type of ovarian cancer. It was not detected in serous borderline tumors and normal ovarian surface epithelium. Inhibition of apoE expression using an apoE-specific siRNA led to G(2) cell cycle arrest and apoptosis in an apoE-expressing ovarian cancer cell line, OVCAR3, but not in apoE-negative cell lines. Furthermore, the phenotype of apoE siRNA-treated OVCAR3 cells was reversed by expressing engineered mutant apoE with introduced silent mutations in the siRNA target sequence. Expression of apoE in nuclei was significantly associated with a better survival in patients who presented peritoneal effusion at the time of diagnosis (5-year follow-up, P = 0.004). This study suggests a new role of apoE in cancer as apoE expression is important for the proliferation and survival in apoE-expressing ovarian cancer cells.
Polymerization of A<sub>2</sub> with B<sub>3</sub> Monomers:  A Facile Approach to Hyperbranched Poly(aryl ester)s (2003)

Hyperbranched polymers have received significant attention due to their unique combination of low viscosity, excellent solubility, and facile synthesis. This paper describes an efficient approach to hyperbranched poly(aryl ester)s via the polycondensation of A2 and B3 monomers. A dilute bisphenol A (A2) solution was added slowly to a dilute 1,3,5-benzenetricarbonyl trichloride (B3) solution at 25 °C to prepare hyperbranched poly(aryl ester)s in the absence of gelation. The molar ratio of A2:B3 was maintained at 1:1, and the maximum final monomer concentration was ∼0.08 M. 1H NMR spectroscopy and derivitization of terminal groups indicated that the phenol functionalities were quantitatively consumed during the polycondensation. Two model compounds were synthesized to identify 1H NMR resonances for linear, dendritic, and terminal units, and the final degree of branching was determined to be ∼50%. Moreover, the hyperbranched polymers exhibited lower glass transition temperatures relative to their linear analogues.
Tactile sensing for an anthropomorphic robotic hand: Hardware and signal processing (2009)

In this paper, a tactile sensing system for an anthropomorphic robot hand is presented. The tactile sensing system is designed as a construction kit making it very versatile. The sensor data preprocessing is embedded into the hand's hardware structure and is fully integrated. The sensor system is able to gather tactile pressure profiles and to measure vibrations in the sensor's cover. Additionally to the introduction of the hardware, the signal processing and the classification of the acquired sensor data will be explained in detail. These algorithms make the tactile sensing system capable to detect contact points, to classify contact patterns and to detect slip conditions during object manipulation and grasping.
Two-stage Fabry-Perot filters as demultiplexers in optical FDMA LANs (1989)

A high-finesse optical filter can be constructed by cascading two moderate-finesse Fabry-Perot filters of different free spectral ranges. Methods for controlling the undesirable interactions within the interfilter cavity are studied. In particular, the use of an isolator, an attenuator, or a length of fiber longer than the coherence length of the light sources used is considered. The use of a three-mirror filter, which avoids the offending cavity altogether, is also considered. The implications on the number of potential users of optical frequency-division multiple-access (FDMA), local-area networks (LANs) are also addressed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Consequences of the avalanche winter 1999 in Switzerland: the intercantonal early warning and crisis information system IFKIS (2004)

After the avalanche winter 1999 in Switzerland the project IFKIS was initiated. The three main parts of the project were the development of a compulsory checklist for avalanche safety services, a modular education and training course program and an information system for security services. The information system was developed in order to improve on the one hand the information flux between the national avalanche warning centre at SLF and the local forecasters and on the other hand the communication between the avalanche security services in the communities. The results are a contribution for a further improvement of the basics of organizational measures in alpine natural hazard risk management.&lt;br /&gt;&lt;br /&gt;\nNach dem Lawinenwinter 1999 wurde in der Schweiz das Projekt IFKIS gestartet. Die Hauptinhalte des Projekts waren die Erarbeitung von Grundlagen für Pflichtenhefte, ein Ausbildungskonzept sowie ein Informationssystem für Sicherungsdienste. Das Informationssystem wurde entwickelt um einerseits den Informationsfluss zwischen der Nationalen Lawinenwarnzentrale am SLF und den lokalen und regionalen Sicherungsdiensten, andererseits aber auch die Kommunikation zwischen den Lawinendiensten zu verbessern. Die Ergebnisse des Projekts sind ein Beitrag für die weitere Verbesserung der Grundlagen für organisatorische Massnahmen für das Risikomanagement alpiner Naturgefahren.
Analog measurement applications for high speed Josephson switches (1981)

This paper reviews high speed analog applications of Josephson switching devices. The design and performance of two different analog sampling circuits is described. A method is proposed for delivering room temperature signals to these samplers with 30 GHz or more of bandwidth. An analog-to-digital converter based on quantum interference comparators is also described. This device has achieved conversion rates of 2 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sup> samples per second.
E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines (2006)

Using genome-wide expression profiling of a panel of 27 human mammary cell lines with different mechanisms of E-cadherin inactivation, we evaluated the relationship between E-cadherin status and gene expression levels. Expression profiles of cell lines with E-cadherin (CDH1) promoter methylation were significantly different from those with CDH1 expression or, surprisingly, those with CDH1 truncating mutations. Furthermore, we found no significant differentially expressed genes between cell lines with wild-type and mutated CDH1. The expression profile complied with the fibroblastic morphology of the cell lines with promoter methylation, suggestive of epithelial-mesenchymal transition (EMT). All other lines, also the cases with CDH1 mutations, had epithelial features. Three non-tumorigenic mammary cell lines derived from normal breast epithelium also showed CDH1 promoter methylation, a fibroblastic phenotype and expression profile. We suggest that CDH1 promoter methylation, but not mutational inactivation, is part of an entire programme, resulting in EMT and increased invasiveness in breast cancer. The molecular events that are part of this programme can be inferred from the differentially expressed genes and include genes from the TGFbeta pathway, transcription factors involved in CDH1 regulation (i.e. ZFHX1B, SNAI2, but not SNAI1, TWIST), annexins, AP1/2 transcription factors and members of the actin and intermediate filament cytoskeleton organisation.
Survey on indoor wireless positioning techniques: Towards adaptive systems (2010)

Indoor positioning remains a challenging research area to be explored. Various kind of indoor positioning systems (IPSs) have been developed based on different techniques and technologies. Parameters such as distance, objects and location of access points can greatly affect the power of received signal strength. In this paper we discuss several existing IPSs and the techniques used with their unique strengths as well as its weaknesses. In addition, this paper elaborates the need of adaptive systems which can be the solution where other systems are unable to accomplish. Finally the reviewed techniques will be evaluated based on its complexity, accuracy and deployment cost to determine its capability in addressing issues in indoor wireless positioning.
A Novel Thermosetting Gel Electrolyte for Stable Quasi‐Solid‐State Dye‐Sensitized Solar Cells (2007)

Using poly(acrylic acid)-poly(ethylene glycol) hybrid-absorbing liquid electrolyte, we prepare a novel thermosetting gel electrolyte (TSGE) with ionic conductivity of 6.12 mS cm–1. Based on the TSGE, a quasi-solid-state dye-sensitized solar cell with a good long-term stability and light-to-electricity conversion efficiency of 6.10 % is attained under AM 1.5 irradiation.
Increased efficacy of a dendritic cell–based therapeutic cancer vaccine with adenosine receptor antagonist and CD73 inhibitor (2017)

Dendritic cells are important in initiating immune responses; therefore, a range of dendritic cell-based approaches have been established to induce immune response against cancer cells. However, the presence of immunosuppressive mediators such as adenosine in the tumor microenvironment reduces the efficacy of dendritic cell-based cancer immunotherapy. In this study, we investigated whether blockade of the A2A adenosine receptor with a selective antagonist and a CD73 inhibitor may increase the efficacy of a dendritic cell-based cancer vaccine. According to the findings, this therapeutic combination reduced tumor growth, prolonged survival of tumor-bearing mice, and enhanced specific antitumor immune responses. Thus, we suggest that targeting cancer-derived adenosine improves the outcomes of dendritic cell-based cancer immunotherapy.
The role of the fibrous capsule in the function of implanted drug‐polymer sustained release systems (1981)

Numerous studies have been carried out on drug-polymer sustained release systems designed for implantation. The majority of these efforts have been directed toward determining the in-vitro rate of drug release from specific systems or drug polymer combinations and the in-vivo studies have attempted to utilize analysis of the blood serum and excretory products as a measure of the release rate and behavior. To gain a better understanding of the influence of the local tissue environment and implant site on release behavior, we have investigated the release behavior of a gentamicin-silicone rubber system implanted in canines. Particular attention has been directed toward investigating the role that the fibrous capsule which eventually surrounds the implant plays in determining the rate and pattern of drug release. The drug burst effect was decreased by the use of a drug-free silicone rubber membrane on the gentamicin-silicone rod implant. Analysis for gentamicin in the tissue adjacent to the implant for periods up to four weeks indicated that the release rate was retarded by the development of the fibrous capsule. The temporal and spatial variations in gentamicin levels in the tissue surrounding the rod implants were determined. In addition, the influence of implant coating and gentamicin loading level in the implant on local tissue concentrations with time were also investigated. These studies provide evidence that the fibrous capsule surrounding a drug-polymer sustained release implant may influence the release behavior of the drug in an advantageous or disadvantageous manner depending upon the desired function of the sustained release system.
A Nonempirical Method Using LC/MS for Determination of the Absolute Configuration of Constituent Amino Acids in a Peptide:  Elucidation of Limitations of Marfey's Method and of Its Separation Mechanism (1997)

As the first step in establishing our proposed method, the advanced Marfey's method, which is planned for the simultaneous determination of the absolute configuration of amino acids in a peptide, we applied Marfey's method to commercially available amino acids, and the separation behavior was examined in detail. Although good resolution of the diastereomeric pair of an individual amino acid was obtained for all amino acids tested and the applicability of the method was confirmed, the (1-fluoro-2,4-dinitrophenyl)-5-l-alaninamide (FDAA) derivative of the l-amino acid was not always eluted prior to its corresponding d-amino acid derivative. Because this proposed method relies on the elution order of a derivatized amino acid with FDAA to determine its absolute configuration, its separation mechanism was carefully investigated using UV and NMR spectral techniques. The results suggested that the resulting conformations of the l- and d-amino acid derivatives are stable and that the resolution between the l- and d-amino acid derivatives is due to the difference in their hydrophobicity, which is derived from the cis- or trans-type arrangement of two more hydrophobic substituents at both α-carbons of an amino acid and l-alanine amide, so that the FDAA derivative of the cis (Z)-type arrangement interacts more strongly with ODS silica gel and has a longer retention time than that of the trans (E)-type arrangement. Therefore, the l-amino acid derivative is usually eluted from the column before its corresponding d-amino acid derivative in Marfey's method. According to this separation mechanism, the elution order of a desired amino acid can be elucidated from the average retention time of the l- and d-amino acid derivatives, and the dl-serine and -asparagine derivatives are critical for Marfey's method.
Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3′-phosphate and 3′-phosphoglycolate ends (2007)

Aprataxin is the causative gene product for early-onset ataxia with ocular motor apraxia and hypoalbuminemia/ataxia with oculomotor apraxia type 1 (EAOH/AOA1), the clinical symptoms of which are predominantly neurological. Although aprataxin has been suggested to be related to DNA single-strand break repair (SSBR), the physiological function of aprataxin remains to be elucidated. DNA single-strand breaks (SSBs) continually produced by endogenous reactive oxygen species or exogenous genotoxic agents, typically possess damaged 3'-ends including 3'-phosphate, 3'-phosphoglycolate, or 3'-alpha, beta-unsaturated aldehyde ends. These damaged 3'-ends should be restored to 3'-hydroxyl ends for subsequent repair processes. Here we demonstrate by in vitro assay that recombinant human aprataxin specifically removes 3'-phosphoglycolate and 3'-phosphate ends at DNA 3'-ends, but not 3'-alpha, beta-unsaturated aldehyde ends, and can act with DNA polymerase beta and DNA ligase III to repair SSBs with these damaged 3'-ends. Furthermore, disease-associated mutant forms of aprataxin lack this removal activity. The findings indicate that aprataxin has an important role in SSBR, that is, it removes blocking molecules from 3'-ends, and that the accumulation of unrepaired SSBs with damaged 3'-ends underlies the pathogenesis of EAOH/AOA1. The findings will provide new insight into the mechanism underlying degeneration and DNA repair in neurons.
Accumulation of bromodeoxyuridine‐labeled cells in central and peripheral lymphoid organs: minimal estimates of prodution and turnover rates of mature lymphocytes (1990)

Daily lymphocyte production in both central and peripheral lymphoid organs was evaluated by associating in vivo incorporation of bromodeoxyuridine (BrdUrd) with cell surface labeling and multi-parameter flow analysis. At least 10% of mature T and B lymphocytes are generated every 24 h. The kinetic behavior of these cell populations differs, however, in that mature B cells are generated predominantly in the precursor compartments of the bone marrow, while most mature T cell generation occurs at the periphery. Therefore, peripheral expansion is the major mechanism of mature T cell production in the adult mouse. By following the accumulation of BrdUrd-labeled cells in peripheral lymphoid organs we found that the progeny of the daily lymphocyte production was sufficient to renew 30%-40% of all peripheral T and B cells every 48 h, demonstrating a high turnover rate of mature lymphocytes. We also examined the conditions of BrdUrd labeling of cycling cells in vivo. We found that while greater than 90% of bone marrow and thymus cells in S phase were labeled with a single injection of BrdUrd, in peripheral lymphoid compartments 70% of T and B cells in S failed to incorporate BrdUrd. Particular schedules of BrdUrd administration were required to overcome the low labeling efficiency of mature cells in vivo. Prolonged BrdUrd administration, however, had toxic effects on resident cells. The low labeling efficiency of BrdUrd incorporation by mature cells, as well as its potential toxicity during prolonged administration, may explain controversial results obtained by the different strategies used to study lymphocyte population dynamics.
Short-term heart rate turbulence analysis versus variability and baroreceptor sensitivity in patients with dilated cardiomyopathy. (2004)

New methods for the analysis of arrhythmias and their hemodynamic consequences have been applied in risk stratification, in particular to patients after myocardial infarction. This study investigates the suitability of short-term heart rate turbulence (HRT) analysis in comparison to heart rate and blood pressure variability as well as baroreceptor sensitivity analyses to characterise the regulatory differences between patients with dilated cardiomyopathy (DCM) and healthy controls. In this study, 30 minutes data of non-invasive continuous blood pressure and ECGs of 37 DCM patients and 167 controls measured under standard resting conditions were analysed. The results show highly significant differences between DCM patients and controls in heart rate and blood pressure variability as well as in baroreceptor sensitivity parameters. Applying a combined heart rate-blood pressure trigger, ventricular premature beats were detected in 24.3% (9) of the DCM patients and 11.3% (19) of the controls. This fact demonstrates the limited applicability of short-term HRT analyses. However, the HRT parameters showed significant differences in this subgroup with ventricular premature beats (turbulence onset: DCM: 1.80+/-2.72, controls: - 4.34+/-3.10, p<0.001; turbulence slope: DCM: 6.75+/-5.50, controls: 21.30+/-17.72, p=0.021). Considering all (including HRT) parameters in the subgroup with ventricular beats, a discrimination rate between DCM patients and controls of 88.0% was obtained (max. 6 parameters). The corresponding value obtained for the total group was 86.3% (without HRT parameters). Comparable classification rates and high correlations between heart rate turbulence and variability and baroreflex parameters point to a more universal applicability of the latter methods.
Chemokine gene polymorphisms associate with gender in patients with uveitis (2003)

Uveitis is an inflammatory condition of ocular tissue characterized by leukocyte infiltration, tissue damage, and decreased visual acuity. Chemokines have been implicated in the pathogenesis of uveitis. Polymorphisms in the genes encoding chemokines have been described as affecting chemokine production or function. We analyzed the frequency of single-nucleotide polymorphisms (SNPs) in genes encoding CCL2 (-2518 and -2076) and CCL5 (-403 and -28) in patients with Behçet's disease (BD), a systemic form of uveitis, and patients with retinal vasculitis (RV), an organ-specific form of disease. We report that there was no association between any SNP and disease. However, when segregated on the basis of gender the CCR5 -403 AA genotype was only found in male patients with BD. Similarly, CCL2 genotypes 1/2 were predominant in males, while genotype 4 was significantly associated with disease in female patients with BD. Differences in disease symptoms and severity between males and females have been described in BD and gender-specific genetic differences in chemokine gene function may be involved.
Securing the World Wide Web: Smart Tokens and Their Implementation (1995)

This paper introduces Smart Tokens, discusses some of their basic properties, and outlines their general role in securing software applications on the World Wide Web. In addition, the completed hardware and software architecture of a current implementation is described. Finally, an electronic commerce application for Smart Tokens involving major U.S. financial institutions is discussed.
Diazo transfer reactions of tosyl azide with carbocyclic β-keto esters: production and decomposition of ring-opened N-tosylcarbamoyl-substituted α-diazo esters (1997)

The diazo transfer reaction of tosyl azide 1 with methyl 2-oxocyclopentanecarboxylate 2a, ethyl 2-oxocyclohexanecarboxylate 2b and methyl 2-oxocycloheptanecarboxylate 2c, in the presence of triethylamine, gives ring-opened diazo amido esters 3a–c in fairly high yields. Similar reaction with ethyl 2-oxocyclooctanecarboxylate 2d and methyl camphor-3-carboxylate 2e also leads to the respective diazo esters 3d,e but accompanied by the corresponding azido transfer products 6, 7 to a significant (or major) extent. The thermal, photochemical and rhodium(II) acetate-catalysed decomposition of the novel diazocarbonyl compounds 3a–e has been examined. The results show that intramolecular cyclization onto the N-tosylcarbamoyl substituent can smoothly take place provided that it gives rise to a six-membered ring ylide or diazonium betaine intermediate. Otherwise, β-hydride elimination by an intermediate carbene or rhodium-carbenoid becomes the preferred, if not exclusive, decomposition mode. However, unusual behaviour is encountered with the diazo amido ester 3d in that its rhodium(II)-induced decomposition results in the preferential formation of the α-hydroxy ester 19.
An empirical evaluation of chains of recurrences for array dependence testing (2006)

Code restructuring compilers rely heavily on program analysis techniques to automatically detect data dependences between program statements. Dependences between statement instances in the iteration space of a loop nest impose ordering constraints that must be preserved in order to produce valid optimized, vectorized, and parallelized loop nests. This paper evaluates a new approach for fast and accurate nonlinear array dependence testing using Chains of Recurrences (CRs). A flow-sensitive loop analysis algorithm is presented for constructing the CR forms of array index expressions. Unlike other approaches, the CR forms are directly integrated into a standard dependence test to solve nonlinear CR-based dependence equations. To study the coverage and performance of the proposed CR-based enhancements of a standard test, we chose the inexact Banerjee test. We implemented a new CR-based Banerjee test in the Polaris compiler and compared the results to the Omega test and Range test on a set of SPEC and LAPACK Benchmark programs. The experimental results suggest that a CR enhancement can dramatically increase the effectiveness of a dependence test without a significant cost increase. More surprisingly, the findings indicate that the enhanced test exceeds the capabilities of the Omega and Range tests for many nonlinear dependence relations detected in the PERFECT Club and LAPACK Benchmark programs.