gebhart/patrepeval huggingface dataset:
A spread stacked capacitor (SSC) cell for 64 Mbit DRAMs (2003)

In order to realize a small memory cell area for 64-Mb DRAMs (dynamic RAMs), a spread stacked capacitor (SSC) cell is proposed. In this cell, the storage electrode of the first memory cell is expanded to the neighboring second memory cell area. Then, the storage electrode of the second memory cell is also expanded to the first memory cell area. Therefore, each storage electrode can occupy two memory cell areas, and the SSC cell can enlarge the storage capacitance to 1.8 times that of the conventional stacked capacitor cell. When the SSC cell is applied to 64-Mb DRAMs, a 27-fF storage capacitance can be achieved using 4-nm-SiO/sub 2/-equivalent-thickness dielectric film.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Challenges for Distributed Event Services: Scalability vs. Expressiveness (1999)

Chiral dirhodium(II) carboxamidates are highly efficient catalysts for reactions between a variety of aldehydes and activated dienes. Catalyst loadings as low at 0.01 mol % have been realized with enantioselectivities up to 97%. Kinetic investigations reveal a pronounced electronic influence on the rate of the hetero-Diels-Alder reaction with a Hammett rho value of +1.9 (versus sigma(+)). Inhibition of the catalyst by reactant aldehyde is apparent, but reactions show first-order dependence on aldehyde and diene, and there is a variable dependence on catalyst.
The natriuretic effect of the dihydropyridine calcium antagonist felodipine: a placebo-controlled study involving intravenous angiotensin II in normotensive volunteers. (1987)

Changes in systemic and renal hemodynamics and in the renin-angiotensin system caused by infusion of the calcium antagonist felodipine were investigated in a placebo-controlled study with 12 normotensive volunteers before and during a graded infusion of angiotensin II (AII). In spite of a fall in blood pressure through vasodilatation, felodipine had a natriuretic effect. There was only a transient rise in effective renal plasma flow (ERPF), whereas glomerular filtration rate (GFR) did not change. Urinary sodium excretion remained elevated when ERPF had normalized. Urinary potassium excretion did not change. AII-induced reductions in ERPF, GFR, and sodium excretion were abolished by felodipine. Felodipine also partly antagonized the rise in plasma aldosterone levels caused by AII. We conclude that the natriuretic effect of dihydropyridine calcium antagonists is probably not caused by a single mechanism, but may be dependent on changes in renal hemodynamics together with a diminished sodium reabsorption at multiple tubular sites. Interference with AII-mediated renal mechanisms and an impairment of the action of aldosterone may contribute to this natriuretic effect as well.
Diagnosis and treatment of patients with bipolar disorder: A review for advanced practice nurses (2015)

Awareness of the disease burden, diagnostic issues, and management choices in BD has the potential to enhance outcome in substantial proportions of patients.
Frequency–wavenumber modelling and migration of 2D GPR data in moderately heterogeneous dispersive media (1998)

An algorithm for modelling and migrating ground penetrating radar (GPR) data in moderately heterogeneous dispersive media is presented. The method is based on wavefield extrapolation in the frequency–wavenumber ( f – k ) domain, from the solution of the 2D Maxwell's equations. The wavefield is extrapolated by a phase‐shift technique using a constant relative permittivity K and a quality factor Q . It is then modified by a correction term to handle the lateral K and Q variations. The spatial distribution of the K and Q ‐factor values, representing the given model parameters, is introduced into the algorithm by a regular grid parametrization. The radar wave dispersion and attenuation, induced by relaxation processes, are taken into account by a linear frequency‐dependent Q model, and expressed by a complex wavenumber in the propagation equation. A synthetic case and a field data set illustrate the potential of the method for frequencies of 300, 500 and 900 MHz. In the first case, a typical civil engineering problem is considered. The frequency dependence of the wave velocity and attenuation is well illustrated. The synthetic data are afterwards migrated using the initial model parameters. The results show the importance of using spatially varying model parameters in the migration processes. The second case concerns an application of the method to a real data set. In order to adjust the model parameters, a forward modelling sequence is performed until the best match between the measured and the synthetic data is achieved. A depth migration is then applied to the data, and the result is compared with the initial model parameters. In conclusion, we assess the contributions of the method to industrial applications, by discussing the performance of the algorithm compared with its limitations.
Increased interleukin 1 beta in human skeletal muscle after exercise (1989)

Interleukin 1 beta (IL-1 beta) is a protein released from blood monocytes and related cells in response to infectious or inflammatory stimuli. Although IL-1 beta is elevated in the circulation for only a few hours after an acute inflammatory challenge or exercise, it has been proposed to mediate anabolic and catabolic processes that can last for several days. In this report, eccentric exercise was used as a noninfectious inflammatory stimulus. IL-1 beta was found in muscle tissue up to 5 days after exercise using specific immunohistochemical tissue staining. Increased IL-1 beta immunoreactivity was observed in muscle tissue from four human subjects who performed the exercise, but not in tissue obtained at the same time intervals from two subjects who did not exercise. Little immunohistochemical evidence of interleukin-1 alpha or tumor necrosis factor alpha was observed before or after exercise. These results implicate IL-1 beta in the metabolic adaptations of muscle tissue, which occur in response to noninfectious stresses.
Pharmacokinetic basis for the use of extended interval dosage regimens of gentamicin in neonates (2004)

According to our pharmacokinetic population model, initial doses of gentamicin of 10 mg/kg, and dosage intervals between 36-48 h, appear to be appropriate to achieve target peak and trough serum levels of 15-20 and <0.5 mg/L, respectively, when extended-interval dosage regimens are implemented in newborns. The half-life of gentamicin in premature babies of very low weight and gestational age <31 weeks is long. Thus, to achieve serum concentrations in the 1-10 mg/L range, the use of dosage regimens of 5 mg/kg at 36-48 h dosage intervals seems suitable.
Automatic spatial planning for machining operations (2015)

We present a novel spatial planning system that automatically generates machining plans with stable fixtures to fabricate complex geometries. Given a cutting tool, the system initially finds all tool poses that do not cut into the desired part geometry, and constructs the maximal volume removable from a raw stock according to the tool's degrees of freedom. The planning space is then defined as the product space of all available tools and their associated maximal removal volumes. A sequence of machining operations to iteratively remove material from a raw stock is generated by searching the planning space and finding successive machining steps that minimize manufacturing time or cost. For each step, a vise or modular fixture is automatically assembled such that the part is stable and the fixture assembly does not interfere with tool motion. Process planning is an inverse problem and multiple feasible solutions exist to machine the part if it is deemed manufacturable by the system. The system generates and visualizes several qualitatively distinct fabrication plans for an engineer to choose from. The chosen plan is sent to a tool path planner to generate machining instructions. We will show several examples of rapid and automatic end-to-end machining process planning on complex geometries to demonstrate the scalability and practicality of our system.
Generation of environmentally enhanced products: clean technology for paper chemicals (1997)

The modification of existing chemical manufacturing processes to selectively remove unwanted chemicals in products, offers a realistic approach to novel clean technologies. Adjunct biotechnological processing offers a means to achieve the manufacture of new environmentally enhanced products (EEPs). This paper describes the development and implementation of a bioprocess for the manufacture of an enhanced paper chemical. The process was integrated into existing manufacturing plants involved in the production of neutral curing poly(aminoamide) chemicals which are used commercially to impart wet-strength to paper products such as tissues and towels (e.g. Kymene™ wet-strength resins). A consequence of the epichlorohydrin chemistry involved in the polymer's manufacture, haloalcohols (predominantly, 1,3-dichloropropan-2-ol (DCP) and 1-chloropropanediol (3-CPD)) contaminate the product. The objective was to reduce the concentration of the two haloalcohols in Kymene™-SLX wet-strength resins (c. 8000 ppm db) without affecting the performance of the product. A two-membered bacterial consortium was used in an aerobic stirred tank bioreactor system which was capable of rapidly reducing the concentrations of DCP and CPD in an aqueous solution of the wet-strength resin to less than 1 ppm and 5 ppm respectively. A 3000 dm3 bioreactor was integrated into two established manufacturing plants, generating a reliable and predictable process to enhance the value of the neutral curing wet-strength chemical. ©1997 SCI
A digitally modulated mm-Wave cartesian beamforming transmitter with quadrature spatial combining (2013)

With fast-growing demand for high-speed mobile communications and highly saturated spectral usage below 10GHz, mm-Wave frequency bands are emerging as the key playground for future high-data-rate wireless standards. Recent years have witnessed vast technology development on V-band (60GHz) Wireless Personal Area Networks (WPAN) and E-band (80GHz) point-to-point cellular backhauls. However, existing integrated CMOS mm-Wave solutions have relatively poor energy efficiency, especially for the transmitter (TX). This is mainly due to the use of traditional Class-A Power Amplifiers (PAs) that provide good linearity but suffer from low efficiency. In addition, the efficiency of Class-A PAs drop dramatically at power back-offs, making these transmitters even less efficient when conveying non-constant envelope signals. State-of-the-art mm-Wave Class-A PAs show less than 5% efficiency at 6dB back-off [1,2].
Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti-tumor necrosis factor α agents (2007)

In contrast to the other anti-TNFalpha agents tested, certolizumab pegol did not mediate increased levels of apoptosis in any of the in vitro assays used, suggesting that these mechanisms are not essential for the efficacy of anti-TNFalpha agents in CD. As certolizumab pegol, infliximab, and adalimumab, but not etanercept, almost completely inhibited LPS-induced IL-1beta release from monocytes, inhibition of cytokine production may be important for efficacy of anti-TNFalpha agents in CD.
Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from <i>Escherichia coli</i> (1998)

Crystal structures of glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase from Escherichia coli have been determined to 2.0-A resolution in the absence of ligands, and to 2.5-A resolution with the feedback inhibitor AMP bound to the PRPP catalytic site. Glutamine PRPP amidotransferase (GPATase) employs separate catalytic domains to abstract nitrogen from the amide of glutamine and to transfer nitrogen to the acceptor substrate PRPP. The unliganded and AMP-bound structures, which are essentially identical, are interpreted as the inhibited form of the enzyme because the two active sites are disconnected and the PRPP active site is solvent exposed. The structures were compared with a previously reported 3.0-A structure of the homologous Bacillus subtilis enzyme (Smith JL et al., 1994, Science 264:1427-1433). The comparison indicates a pattern of conservation of peptide structures involved with catalysis and variability in enzyme regulatory functions. Control of glutaminase activity, communication between the active sites, and regulation by feedback inhibitors are addressed differently by E. coli and B. subtilis GPATases. The E. coli enzyme is a prototype for the metal-free GPATases, whereas the B. subtilis enzyme represents the metal-containing enzymes. The structure of the E. coli enzyme suggests that a common ancestor of the two enzyme subfamilies may have included an Fe-S cluster.
Novel One-Phase Synthesis of Thiol-Functionalized Gold, Palladium, and Iridium Nanoparticles Using Superhydride (1999)

A new, facile, general one-phase synthesis for thiol-functionalized gold, palladium, and iridium nanoparticles, using tetrahydrofuran (THF) as the solvent and lithium triethylborohydride (Superhydride) as the reducing agent, is presented. For octadecanethiol-functionalized gold (Au/ODT) nanoparticles, HRTEM of drop-cast particle-films revealed the formation of spherical particles of d = 4 ± 0.3 nm average size. Electron diffraction shows fcc packing arrangement, similar to that of bulk gold. The crystalline gold cores are surrounded with closely packed n-alkyl chains mainly in an all-trans conformation, adopting orthorhombic packing as confirmed by FTIR spectroscopy. Particles are arranged in a discrete solidlike assembly with a correlation length of ∼5 nm, as the interparticle distance (center-to-center) and a constant edge-to-edge distance of 1 nm as shown by FFT analysis. Using the same synthetic procedure gold nanoparticles functionalized with 11-hydroxyundecane-1-thiol and with 4‘-bromo-4-mercaptobiphenyl were prepared. TEM images of drop-cast Pd/ODT and Ir/ODT nanoparticles show an average size of 2.25 nm for the former, while for the latter the distribution is broader with the majority of particles between 2.25 and 4.25 nm. Both nanoparticles are crystalline with fcc packing. FTIR spectroscopy reveals that octadecyl chains are close-packed in all-trans conformation, and that there is presumably one chain in unit cell.
Intermolecular reactions of electron-rich heterocycles with copper and rhodium carbenoids (2007)

This tutorial review describes the reactions of the electron-rich heterocycles pyrrole, furan, indole and benzofuran with copper and rhodium carbenoids. Two main reaction pathways are possible, involving either a concerted non-synchronous cyclopropanation or zwitterionic intermediates. A diverse range of products are possible and the outcome is very dependent on the structure of the heterocycle and the carbenoid. To emphasize this point the carbenoids are considered in terms of three classes: acceptor, acceptor-acceptor and donor-acceptor carbenoids. Unusual catalytic asymmetric transformations can be achieved with this chemistry while the asymmetric induction is strongly influenced by how the carbenoid can approach the heterocycles. This tutorial review gives an overview of the general features that govern the chemistry of metal carbenoids with heterocycles and presents a mechanistic rationale for the range of products that can be formed.
Systemic sclerosis: a prototypic multisystem fibrotic disorder (2007)

A unique feature of systemic sclerosis (SSc) that distinguishes it from other fibrotic disorders is that autoimmunity and vasculopathy characteristically precede fibrosis. Moreover, fibrosis in SSc is not restricted to a single organ, but rather affects many organs and accounts for much of the morbidity and mortality associated with this disease. Although immunomodulatory drugs have been used extensively in the treatment of SSc, no therapy to date has been able to reverse or slow the progression of tissue fibrosis or substantially modify the natural progression of the disease. In this Review, we highlight recent studies that shed light on the cellular and molecular mechanisms underlying the fibrotic process in SSc and that identify cellular processes and intra- and extracellular proteins as potential novel targets for therapy in this prototypic multisystemic fibrotic disease.
p27KIP1phosphorylation by PKB/Akt leads to poor breast cancer prognosis (2003)

Three papers published concurrently in the October issue of Nature Medicine have demonstrated new links between mitogenic cytokine signalling and the cell cycle inhibitor p27KIP1, and have elucidated how this link may contribute to breast cancer patient prognosis [1-3].

Cell cycle control occurs through cyclin binding to the cyclin-dependent kinases (CDKs) that stimulate G1 progression [4]. p27KIP1 is a member of the kinase inhibitor protein (KIP) family that inhibit cell cycle progression by binding to cyclin-CDK complexes [5]. In cancers where protein kinase B (PKB)/Akt is constitutively activated by upstream oncogenes, Akt decreases p27KIP1 by increasing proteolysis and reducing transcription [6].

These three articles describe a third way in which Akt resists G1 arrest, namely by a p27KIP1 phosphorylation that impairs nuclear import and prevents its inhibition of cyclin-CDK complexes. The authors of these studies conclude that exclusion of p27KIP1 from the nucleus leads to a poor patient outcome in breast cancer [1-3].
Crowd-powered parameter analysis for visual design exploration (2014)

Parameter tweaking is one of the fundamental tasks in the editing of visual digital contents, such as correcting photo color or executing blendshape facial expression control. A problem with parameter tweaking is that it often requires much time and effort to explore a high-dimensional parameter space. We present a new technique to analyze such high-dimensional parameter space to obtain a distribution of human preference. Our method uses crowdsourcing to gather pairwise comparisons between various parameter sets. As a result of analysis, the user obtains a goodness function that computes the goodness value of a given parameter set. This goodness function enables two interfaces for exploration: Smart Suggestion, which provides suggestions of preferable parameter sets, and VisOpt Slider, which interactively visualizes the distribution of goodness values on sliders and gently optimizes slider values while the user is editing. We created four applications with different design parameter spaces. As a result, the system could facilitate the user's design exploration.
Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte antiadhesion activities (1992)

Two strategies for the design of therapeutically useful cannabinoids have been combined to produce compounds with greatly increased antiinflammatory activity and with a low potential for adverse side effects. Enantiomeric cannabinoids with a carboxylic acid group at position 7 and with an elongated and branched alkyl sidechain at position 5' have been synthesized and tested for antiinflammatory activity. They were effective when given orally at doses of 10 micrograms/kg in reducing paw edema in mice that had been induced by either arachidonic acid or platelet activating factor. Leukocyte adhesion to culture dishes was also reduced in peritoneal cells from mice in which the cannabinoids were orally administered in the same dose range as for the paw edema tests. Antinociception could be observed in the mouse hot plate assay; however, little stereochemical preference was seen in contrast to the above tests where the 3R,4R compounds are more active than the 3S,4S enantiomers. Finally, in agreement with earlier reports on the naturally occurring pentyl side chain acids, the synthetic acids showed little activity in producing catalepsy in the mouse, suggesting that they would be nonpsychotropic in humans.
Recombinant subviral particles from tick-borne encephalitis virus are fusogenic and provide a model system for studying flavivirus envelope glycoprotein functions (1996)

Recombinant subviral particles (RSPs) obtained by coexpression of the envelope (E) and premembrane (prM) proteins of tick-borne encephalitis virus in COS cells (S. L. Allison, K. Stadler, C. W. Mandl, C. Kunz, and F. X. Heinz, J. Virol. 69:5816-5820, 1995) were extensively characterized and shown to be ordered structures containing envelope glycoproteins with structural and functional properties very similar to those in the virion envelope. The particles were spherical, with a diameter of about 30 nm and a buoyant density of 1.14 g/cm3 in sucrose gradients. They contained mature E proteins with endoglycosidase H-resistant glycans as well as fully cleaved mature M proteins. Cleavage of prM, which requires an acidic pH in exocytic compartments, could be inhibited by treatment of transfected cells with ammonium chloride, implying a common maturation pathway for RSPs and virions. RSPs incorporated [14C]choline but not [3H]uridine, demonstrating that they contain lipid but probably lack nucleic acid. The envelope proteins of RSPs exhibited a native antigenic and oligomeric structure compared with virions, and incubation at an acidic pH (pH <6.5) induced identical conformational changes and structural rearrangements, including an irreversible quantitative conversion of dimers to trimers. The RSPs were also shown to be functionally active, inducing membrane fusion in a low-pH-dependent manner and demonstrating the same specific hemagglutination activity as whole virions. Tick-borne encephalitis virus RSPs thus represent an excellent model system for investigating the structural basis of viral envelope glycoprotein functions.