gebhart/patrepeval huggingface dataset:
Disease Detection and Management via Single Nanopore-Based Sensors (2012)

ADVERTISEMENT RETURN TO ISSUEPREVReviewDisease Detection and Management via Single Nanopore-Based SensorsJoseph E. Reiner*†, Arvind Balijepalli‡§, Joseph W. F. Robertson‡, Jason Campbell‡, John Suehle‡, and John J. Kasianowicz‡View Author Information† Department of Physics, Virginia Commonwealth University, 701 W. Grace Street, Richmond, Virginia 23284, United States‡ Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8120, United States§ Laboratory of Computational Biology, National Heart Lung and Blood Institute, Rockville, Maryland 20852, United States*E-mail: [email protected]Cite this: Chem. Rev. 2012, 112, 12, 6431–6451Publication Date (Web):November 16, 2012Publication History Received13 September 2012Published online16 November 2012Published inissue 12 December 2012https://doi.org/10.1021/cr300381mCopyright © 2012 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views4621Altmetric-Citations190LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (14 MB) Get e-AlertsSUBJECTS:Electrical conductivity,Genetics,Ions,Molecules,Nanopores Get e-Alerts
Computation of Likelihood Ratios in Fingerprint Identification for Configurations of Any Number of Minutiæ (2006)

Recent court challenges have highlighted the need for statistical research on fingerprint identification. This paper proposes a model for computing likelihood ratios (LRs) to assess the evidential value of comparisons with any number of minutiae. The model considers minutiae type, direction and relative spatial relationships. It expands on previous work on three minutiae by adopting a spatial modeling using radial triangulation and a probabilistic distortion model for assessing the numerator of the LR. The model has been tested on a sample of 686 ulnar loops and 204 arches. Features vectors used for statistical analysis have been obtained following a preprocessing step based on Gabor filtering and image processing to extract minutiae data. The metric used to assess similarity between two feature vectors is based on an Euclidean distance measure. Tippett plots and rates of misleading evidence have been used as performance indicators of the model. The model has shown encouraging behavior with low rates of misleading evidence and a LR power of the model increasing significantly with the number of minutiae. The LRs that it provides are highly indicative of identity of source on a significant proportion of cases, even when considering configurations with few minutiae. In contrast with previous research, the model, in addition to minutia type and direction, incorporates spatial relationships of minutiae without introducing probabilistic independence assumptions. The model also accounts for finger distortion.
Type 1 Phototherapeutic Agents, Part I: Preparation and Cancer Cell Viability Studies of Novel Photolabile Sulfenamides (2011)

Novel type 1 phototherapeutic agents based on compounds containing S-N bonds (sulfenamides) were synthesized, assessed for free radical generation, and evaluated in vitro for cell death efficacy in four cancer cell lines (U937, HTC11, KB, and HT29). All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance spectroscopy. Among the sulfenamides, the most potent compounds were derived from dibenzazepine 7b and dihydroacridine 8b as determined in all of the four cancer cell lines.
Poly-L-lysine and multioligo(L-methionyl) poly-L-lysine as nutritional sources of essential amino acids (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly-L-lysine and multioligo(L-methionyl) poly-L-lysine as nutritional sources of essential amino acidsDaniel Bercovici, Hubert F. Gaertner, and Antoine J. PuigserverCite this: J. Agric. Food Chem. 1989, 37, 4, 873–877Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/jf00088a009https://doi.org/10.1021/jf00088a009research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Studies on improved Agrobacterium-mediated transformation in two indica rice (Oryza sativa L.) (2004)

Agrobacterium tumefaciens strain EHA 105 carrying binary vector pCAMBIA 1301 was used for transformation in two economically important highly recalcitrant indica rice cultivars HKR-46 and HKR-126. High concentrations of acetosyringone in the agrobacterium culture and co-cultivation medium proved to be indispensable for successful transformation. Embryogenic scutellar calli were used for transformation studies. Binary vector pCAMBIA 1301 have been proved efficient for transformation. The percent transient GUS expression found to be higher in cutivar HKR-126 (44.4%) as compared to HKR-46 (28.9%). The percent recovery of hygromycin resistant calli after 4-6 weeks on selection medium was maximum in HKR-126 (52.6%). Key Words: Agrobacterium , indica rice, transformation, acetosyringone. African Journal of Biotechnology Vol.3(11) 2004: 572-575
MERCURY SEPARATION AND IMMOBILIZATION USING SELF-ASSEMBLED MONOLAYERS ON MESOPOROUS SUPPORTS (SAMMS) (1999)

ABSTRACT Mercury (Hg) is one of the most toxic metals found in the environment. The purpose of this study was to investigate the performance of an innovative technology, self-assembled monolayers on mesoporous supports (SAMMS), in separating and immobilizing Hg from aqueous solutions. The high surface area of the mesoporous silica and the covalent binding between the thiol (-SH) group in SAMMS and Hg in solution provide SAMMS with distinctive advantages over existing technologies. The results show that (i) the Hg removal is kinetically quite rapid, (ii) the sorption data follow Langmuir isotherms, (iii) the maximum sorption capacity could be up to 613 mg of Hg per gram of SAMMS, (iv) SAMMS was able to reduce Hg concentrations to below the national pollution discharge emission standard level (12 ppt), (v) the Hg-laden SAMMS was stable in aqueous solution at 70°C, and (vi) the Hg-laden SAMMS was able to pass TCLP (Toxicity Characterization Leaching Procedure) tests of the U.S. Environmental Protection Agency. The results, therefore, suggest that SAMMS has a strong potential to be used for the removal and immobilization of Hg and that the Hg-laden SAMMS is suitable for long-term disposal.
Cytoplasmic transfer of the mitogenic response to platelet-derived growth factor. (1981)

BALB/c 3T3 mouse cells exposed briefly to platelet-derived growth factor (PDGF) become "competent" to replicate their DNA and divide. When cells are treated with PDGF and then fused to untreated cells, the resulting heterokaryons become competent to replicate their DNA. Cytoplasts derived from PDGF-treated cells are also able to transfer the growth response to untreated cells. After cytoplasmic transfer to another cell, the strength of the PDGF-induced mitogenic signal is attenuated by a factor roughly proportional to the increase in total cytoplasmic volume. When RNA synthesis is blocked during PDGF treatment, cells do not acquire the capacity to transfer the PDGF growth signal to untreated cells. By contrast, exposure to cycloheximide during PDGF treatment has no effect. These observations suggest that cytoplasmic transfer of the growth response to PDGF (competence) is mediated by a PDGF-induced stable RNA rather than by PDGF itself or a PDGF--receptor complex. The onset of DNA synthesis in PDGF--control heterokaryons occurs a minimum of 11 hr after cell fusion. Thus the substance that is transferred in these cell fusions is not directly involved in DNA synthesis; rather, it seems to trigger a sequence of events culminating in DNA synthesis.
New Approach to Pulmonary Vein Isolation for Atrial Fibrillation Using a Multielectrode Basket Catheter (2005)

This new approach for PV isolation during distal PV pacing using a basket catheter is useful for confirming bidirectional PV - LA conduction block. PV isolation that creates not only an entrance block but also an exit block at the PV - LA junction may be required to cure paroxysmal AF.
Phylogeny of genes for secretion NTPases: Identification of the widespread tadA subfamily and development of a diagnostic key for gene (2001)

Macromolecular transport systems in bacteria currently are classi- fied by function and sequence comparisons into five basic types. In this classification system, type II and type IV secretion systems both possess members of a superfamily of genes for putative NTP hydrolase (NTPase) proteins that are strikingly similar in structure, function, and sequence. These include VirB11, TrbB, TraG, GspE, PilB, PilT, and ComG1. The predicted protein product of tadA ,a recently discovered gene required for tenacious adherence of Actinobacillus actinomycetemcomitans, also has significant se- quence similarity to members of this superfamily and to several unclassified and uncharacterized gene products of both Archaea and Bacteria. To understand the relationship of tadA and tadA-like genes to those encoding the putative NTPases of type IIyIV secre- tion, we used a phylogenetic approach to obtain a genealogy of 148 NTPase genes and reconstruct a scenario of gene superfamily evolution. In this phylogeny, clear distinctions can be made be- tween type II and type IV families and their constituent subfamilies. In addition, the subgroup containing tadA constitutes a novel and extremely widespread subfamily of the family encompassing all putative NTPases of type IV secretion systems. We report diagnos- tic amino acid residue positions for each major monophyletic family and subfamily in the phylogenetic tree, and we propose an easy method for precisely classifying and naming putative NTPase genes based on phylogeny. This molecular key-based method can be applied to other gene superfamilies and represents a valuable tool for genome analysis.
Metastatic myeloma? (2012)

and that dialing down CXCR4 signaling is an ideal therapeutic strategy. In the future, it may help accelerate preclinical development of drug candidates while continuing to reveal surprising new concepts about pathogenesis and the normal role of CXCR4 in hematopoiesis.
Magnetoelectric and multiferroic media (2012)

The last decade has witnessed a significant growth of research into materials with coupled magnetic and electric properties. Reviewed here are the main types and mechanisms of magnetoelectric interactions and conditions of their origin. Special attention is given to potentially practical materials that display magnetoelectric properties at room temperature. Example applications of magnetoelectric materials and multiferroics in information and energy saving technologies are discussed.
High speed ICs for optical communications (1998)

Summary form only given. This tutorial will focus on the electronics circuits used in ultra high speed TDM lightwave systems. Modulator drivers, laser drivers, preamplifiers, gain control amplifiers, clock recovery circuits, multiplexers, demultiplexers, along with packaging issues will be featured. Examples of these circuits implemented with high speed AlGaAs-GaAs HBTs, and HEMTs will be discussed.
Liquid Crystalline Composite Based on a Clay Mineral (1996)

Abstract Novel liquid crystalline composites (LCC) based on a nematic liquid crystal and fine plate-like caly minerals have been prepared by mixing the two components. The observation of the LCCs by a polarized optical microscope revealed that the plate like particles of the clay mineral were dispersed homogeneously and their sizes were about several micrometers or less. In a nematic phase, the LCCs exhibit a very fine multidomain. structure which is the cause of a light scattering effect of the LCC cells. When an electric field was applied to the cell, it became transparent from milky white. Even after the electric field was switched off, the transparent state was maintained, thus exhibiting memory effect. After 3 months, no change in the transparency of the memory state was observed. Also, the thermo-optic effect of the LCC cells was discussed.
Effect of test conditions and interfering factors on sensitivity of bacterial tests based on inhibition of growth and motility (1992)

Abstract The effect of test conditions on the sensitivity of the swarming activity of Proteus mirabilis and Azospirillum brasilense , of the cup plate assay ( Bacillus thuringiensis ), and of a cell counting assay in liquid medium using a Coulter Counter ( B. thuringiensis ) was studied. Tested substances were pesticides, mycotoxins, lactones, and anhydrides. Sensitivity was increased by cell counting (up to 1000‐fold), by variation of nutrient concentration and pH in the culture medium, by density of inoculum, by preincubation at 4 or 44°C, by incubation with a detergent, and by the use of sensitive mutants. Interferences were exerted by certain substances and toxin mixtures. They included synergistic and antagonistic effects as well as oscillations, e.g., concentration‐dependent activation and inactivation. © 1992 John Wiley &amp; sons, Inc.
On the Origin of Cancer Cells (1956)

2,9569,249MetricsTotal Downloads2,956Last 6 Months581Last 12 Months1,079Total Citations9,249Last 6 Months365Last 12 Months686View all metrics
Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes. (1987)

The tumor necrosis factor (TNF) alpha and beta gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.
Cytoreductive surgery and adjuvant immunotherapy: a new management paradigm for metastatic melanoma (1999)

Although patients with metastatic disease are usually not offered surgery as part of their comprehensive treatment plan, the authors suggest that surgical reduction of the tumor burden may enhance the host immune response and create a favorable setting for the use of active specific immunotherapy.
Pharmacokinetics of factors IX, recombinant human activated factor VII and factor XIII (2006)

Summary. There is now a volume of literature on the pharmacokinetics (PK) of coagulation factor concentrates, although the majority is on factor VIII (FVIII) and factor IX (FIX). PK of FIX and FVIII are different with FIX having a larger volume of distribution ( V dss ), higher elimination clearance (CL), longer mean resident time (MRT) and longer terminal half‐life ( T 1/2, β ). Factor IX in vivo recovery (IVR) is also much shorter possibly due to reversible binding of FIX to the endothelium and possibly to platelets. There is considerable FIX PK variability between products (particularly between plasma‐derived FIX and recombinant FIX), and between individuals. Important inter‐individual factors leading to PK variability include age and body weight because plasma volume as a fraction of body weight decreases with increasing weight and hence age. Thus, IVR increases with body weight and hence age and is consequently lower in children than in adults. Absolute V dss and CL increase linearly with body weight and age in children and adolescents, becoming stable in adults with more stable weight. Inter‐individual variability also likely applies to other clotting factors, particularly to recombinant activated FVII (rFVIIa) but likely also to the less well studied factor XIII (FXIII). The former is known to have an extremely short T 1/2, β , large V dss , high CL, short MRT, whereas the latter has an extremely long T 1/2, β , large V dss , short CL and long MRT. Both are discussed in this article. Understanding of PK of specific clotting factors in individual patients is important in order to make decisions regarding appropriate dosage and dosage intervals to treat patients, and to allow by means of computer modelling the determination of dosage to achieve target trough level at various dosing intervals for patients undergoing prophylaxis.
Oxidative Processes in Polymer-Metal Complexes: A New Way to Prepare Polyampholytes with Groups of α-Picolinic Acid (1999)

Abstract The catalytic reaction of hydrogen peroxide decomposition in aqueous solution in the presence of Cu(II)-containing ion-exchange resins of the poly-α-picolinic type (AN-25, AN-251) was studied. It has been shown using the EPR and IR spectroscopies that in these polymers the methyl groups of the 2-methyl-5-vinylpyridine residues are oxidized to carboxyl groups forming fragments of α-picolinic acid, producing a new chelating ion-exchanger.
Grating formation in a germanium free silicon oxynitride fibre (1997)

For the first time, Bragg gratings have been written in a germanium-free nitrogen-doped-silica-core fibre. Index changes as high as 8.4 × 10–4 have been achieved in the gratings under exposure to 193 nm light without hydrogen loading. The grating growth dynamics is similar to that in heavily doped germanosilicate fibres.
Head and Interface for High Areal Density Tape Recording (2012)

A tape recording head in which reading and writing functions are provided by separate modules is presented. The read-only module may be fabricated with a thinner gap than conventional read-write modules. This was shown to provide <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${&gt;}40\hbox{\%}$</tex> </formula> less gap recession in a controlled wear test. Writing modules are configured to contact tape in one tape motion direction only, thus reducing the wear duty cycle twofold. Modeling indicates that broadband signal-to-noise ratio decline due to wear can be up to several dB less for the separated reading-writing head, which therefore may enable advances in linear and thus areal density.
Assessment of Energy Storage Alternatives in the Puget Sound Energy System (2013)

As part of an ongoing study co-funded by the Bonneville Power Administration, under its Technology Innovation Grant Program, and the U.S. Department of Energy, the Pacific Northwest National Laboratory (PNNL) has developed an approach and modeling tool for assessing the net benefits of using energy storage located close to the customer in the distribution grid to manage demand. PNNL in collaboration with PSE and Primus Power has evaluated the net benefits of placing a zinc bromide battery system at two locations in the PSE system (Baker River / Rockport and Bainbridge Island). Energy storage can provide a number of benefits to the utility through the increased flexibility it provides to the grid system. Applications evaluated in the assessment include capacity value, balancing services, arbitrage, distribution deferral and outage mitigation. This report outlines the methodology developed for this study and Phase I results.
Benzophenone guttiferone A from Garcinia achachairu Rusby (Clusiaceae) Presents Genotoxic Effects in Different Cells of Mice (2013)

Benzophenones from natural sources and those of synthetic analogues present several reports of potent biological properties, and Guttiferone A represents a promising medicinal natural compound with analgesic and gastroprotective profiles. Considering that there are no reports that assess the genetic toxicity of Guttiferone A, the present study was undertaken to investigate the genotoxic potential of this benzophenone isolated from seeds of Garcinia achachairu in terms of DNA damage in different cells of Swiss albino mice using the comet assay, and its clastogenic/aneugenic effects in bone marrow cells in vivo by the micronucleus test. Cytotoxicity was assessed by scoring polychromatic (PCE) and normochromatic (NCE) erythrocytes ratio. Guttiferone A was administered by oral gavage at doses of 15, 30 and 60 mg/kg. The results showed that Guttiferone A produced genotoxic effects in leukocytes, liver, bone marrow, brain and testicle cells and clastogenic/aneugenic effects in bone marrow erythrocytes of mice. The PCE/NCE ratio indicated no cytotoxicity. Since guttiferone A is harmful to the genetic material we suggest caution in its use by humans.
Thermal Behavior of Proteins:  Heat-Resistant Proteins and Their Heat-Induced Secondary Structural Changes (2000)

Most proteins are denatured by heat treatment, and the process is usually irreversible. However, some proteins, such as hyperthermophilic proteins are known to be stable even at the boiling temperature of water. We here describe a systematic investigation of thermal behavior of proteins by purifying and characterizing some heat-resistant proteins (HRPs) that are not aggregated upon heat treatment. Although most proteins were precipitated by boiling in a water bath, about 20 and 70 wt % of total proteins appeared to be heat-resistant in Jurkat T-cell lysates and human serum, respectively. We identified major HRPs from Jurkat T-cells and human serum by N-terminal amino acid sequencing and Western blot analysis. HRPs of 20 and 45 kDa (HRP20 and HRP45) were identified as alpha-synuclein and calreticulin, respectively, and HRPs of 60, 27, and 16 kDa (HRP60, HRP27, and HRP16) were identified as human serum fetuin, apolipoprotein A-I, and transthyretin, respectively. By a systematic investigation of the effect of heat on the secondary structure of the purified HRPs by circular dichroic spectroscopy, we observed four major types of thermal behavior, suggesting that the proteins could protect themselves through these pathways. Although our analysis is restricted to protein secondary structural changes, our data indicate that heat resistance of protein can be achieved in several different ways depending on the thermodynamic stability of native (N), unfolded (U), denatured (D), and intermediate (I) states.