gebhart/patrepeval huggingface dataset:
Sclareol exerts anti-osteoarthritic activities in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model. (2015)

Sclareol is a natural product initially isolated form Salvia sclarea which possesses immune-regulation and anti-inflammatory activities. However, the anti-osteoarthritic properties of sclareol have not been investigated. The present study is aimed at evaluating the potential effects of sclareol in interleukin-1β (IL-1β)-induced rabbit chondrocytes as well as an experimental rabbit knee osteoarthritis model induced by anterior cruciate ligament transection (ACLT). Cultured rabbit chondrocytes were pretreated with 1, 5 and 10 μg/mL sclareol for 1 h and followed by stimulation of IL-1β (10 ng/mL) for 24 h. Gene expression of matrix metalloproteinase-1 (MMP-1), MMP-3, MMP-13, tissue inhibitors of metalloproteinase-1 (TIMP-1), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 was determined by quantitative real-time polymerase chain reaction (qRT-PCR). MMP-3, TIMP-1, iNOS and COX-2 proteins were measured by Western blotting. Enzyme-linked immunosorbent assay (ELISA) was applied for nitric oxide (NO) and prostaglandin E2 (PGE2) assessment. For the in vivo study, rabbits received six weekly 0.3 mL sclareol (10 μg/mL) intra-articular injections in the knees four weeks after ACLT surgery. Cartilage was harvested for measurement of MMP-1, MMP-3, MMP-13, TIMP-1, iNOS and COX-2 by qRT-PCR, while femoral condyles were used for histological evaluation. The in vitro results we obtained showed that sclareol inhibited the MMPs, iNOS and COX-2 expression on mRNA and protein levels, while increased the TIMP-1 expression. And over-production of NO and PGE2 was also suppressed. For the in vivo study, both qRT-PCR results and histological evaluation confirmed that sclareol ameliorated cartilage degradation. Hence, we speculated that sclareol may be an ideal approach for treating osteoarthritis.
Dose calculation of anticancer drugs: a review of the current practice and introduction of an alternative. (1996)

The routine use of BSA for dose calculation should be reevaluated. Other methods of dose calculation should be investigated. TDM may be impractical in all patients and remains unvalidated. PMT dosing ensures that the condition of each individual is considered, to predict drug effects better. Clinical dose-calculation systems such as PMT dosing should be evaluated prospectively.
Noise Isolation Standards in Condominiums -- Awaiting Revision of Section 9.11 of the National Building Code (1986)

SOMMAIREJusqu' rcemment, la plupart des difices logements multiples de la rgion de Montral n'avaient qu'une vocation locative.Les prix des loyers taient fixs selon le march et selon la qualit des constructions.Le dmnagement tait la solution la plus souvent adopte lorsque les conditions de location taient juges inacceptables, cause du manque d'isolement acoustique, ou pour toutes autres raisons.
Growth of Colloidal Gold Nanostars and Nanowires Induced by Palladium Doping (2006)

Gold-palladium nanocrystals with starlike shapes and high aspect ratio nanowires were grown in a surfactant solution. The incorporation of palladium into the growing gold nanostructures induced nanowire formation with high yield. Kinetic control of the metal deposition rate through tuning of the pH value to about 5 was crucial for the nanowire growth. The nanostructures were characterized by high-resolution electron microscopy and energy-dispersive X-ray spectroscopy. The Au-Pd nanowires were deposited on functionalized silicon wafers.
Complex Formation among the RNA Export Proteins Nup98, Rae1/Gle2, and TAP (2003)

Most nucleocytoplasmic traffic through the nuclear pore complex is mediated by soluble receptors of the importin/exportin or karyopherin family. mRNA export is unique in that no receptor of this family has been implicated in trafficking of the bulk of mRNAs. Instead, many diverse proteins have been linked to mRNA export, but an all-encompassing model remains elusive. Understanding how these proteins interact with each other is central to the development of such a model. Here, we have focused on the interactions between three proteins implicated in mRNA export, Nup98, Rae1/Gle2, and TAP. We have defined the binary complexes that form among these proteins. We find that Gle2 requires two sites within TAP for stable interaction. Strikingly, rather than a general affinity for all nucleoporin FG repeats, TAP has highest affinity for a specific region within the GLFG domain of Nup98, indicating that not all repeats are identical in function. We have established that the ternary complex can form through simultaneous binding of both Gle2 and TAP to adjacent sites on Nup98. In contrast, Nup98 competes with TAP for Gle2 binding; when bound to Nup98, Gle2 no longer interacts directly with TAP. From these interactions, we propose that Gle2 may act to deliver TAP to Nup98 and that this may represent the first in a series of interactions between an export complex and a nucleoporin.
A General Approach to Programmable and Reconfigurable Emulation of Power Impedances (2017)

Starting with a brief review on the existing methods of impedance emulation, this paper addresses a general and systematic approach to programmable and reconfigurable emulation of power impedances. The proposed approach not only enables the impedance value to be programed, but also allows the characteristics (i.e., type) of the impedance to be reconfigured instantly during the operation. Based on the proposed control method, emulation of at least six types of emulated power impedances (EPI) can be easily attained. In particular, it is theoretically and practically demonstrated that the impedance characteristic can be emulated through a combination of different functions. The systematic derivation of these functions is explained. New techniques that compensate the circuit power losses are introduced. This general approach has been practically verified in several EPI. Both steady-state and dynamic performance of these EPI confirm the programmability and reconfigurability. It is envisaged that the proposed method can be applied to a range of functions, such as power filtering, energy storage, and even power conversion based on direct impedance control.
Space-efficient scheduling of parallelism with synchronization variables (1997)

Recent work on scheduling algorithms has resulted in provable bounds on the space taken by parallel computations in relation to the space taken by sequential computations. The results for online versions of these algorithms, however, have been limited to computations in which threads can only synchronize with ancestor or sibling threads. Such computations do not include Ianguages with futures or user-specified synchronize ation const mints. Here we extend the results to languages with synchronization variables. Such languages include languages with futures, such as Multilisp and Cool, as well as other languages such as ID.
Preprocessing tool for compressed video editing (1999)

This paper presents a simple and effective preprocessing method developed for editing compressed video sequences. The proposed method involves extracting information about different video segments from the compressed bitstream. The algorithm is not designed to distinguish among types of segments but rather to indicate the position and duration. Since no decoding of the bitstream is done, the computational load of the algorithm is very low. Although the experimental results are shown on MPEG compressed video sequences, the algorithm can easily be applied to MJPEG, MPEG4 sequences given the header information.
Cross-Species Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a New World Monkey Colony (2011)

Adenoviruses are DNA viruses that naturally infect many vertebrates, including humans and monkeys, and cause a wide range of clinical illnesses in humans. Infection from individual strains has conventionally been thought to be species-specific. Here we applied the Virochip, a pan-viral microarray, to identify a novel adenovirus (TMAdV, titi monkey adenovirus) as the cause of a deadly outbreak in a closed colony of New World monkeys (titi monkeys; Callicebus cupreus) at the California National Primate Research Center (CNPRC). Among 65 titi monkeys housed in a building, 23 (34%) developed upper respiratory symptoms that progressed to fulminant pneumonia and hepatitis, and 19 of 23 monkeys, or 83% of those infected, died or were humanely euthanized. Whole-genome sequencing of TMAdV revealed that this adenovirus is a new species and highly divergent, sharing <57% pairwise nucleotide identity with other adenoviruses. Cultivation of TMAdV was successful in a human A549 lung adenocarcinoma cell line, but not in primary or established monkey kidney cells. At the onset of the outbreak, the researcher in closest contact with the monkeys developed an acute respiratory illness, with symptoms persisting for 4 weeks, and had a convalescent serum sample seropositive for TMAdV. A clinically ill family member, despite having no contact with the CNPRC, also tested positive, and screening of a set of 81 random adult blood donors from the Western United States detected TMAdV-specific neutralizing antibodies in 2 individuals (2/81, or 2.5%). These findings raise the possibility of zoonotic infection by TMAdV and human-to-human transmission of the virus in the population. Given the unusually high case fatality rate from the outbreak (83%), it is unlikely that titi monkeys are the native host species for TMAdV, and the natural reservoir of the virus is still unknown. The discovery of TMAdV, a novel adenovirus with the capacity to infect both monkeys and humans, suggests that adenoviruses should be monitored closely as potential causes of cross-species outbreaks.
Identification and characterization of a novel member of the fibroblast growth factor family (1998)

A new member of the fibroblast growth factor (FGF) family, FGF-13, has been molecularly cloned as a result of high throughput sequencing of a human ovarian cancer cell library. The open reading frame of the novel human gene (1419 bp) encodes for a protein of 216 a.a. with a molecular weight of 22 kDa. The FGF-13 sequence contains an amino-terminal hydrophobic region of 23 a.a. characteristic of a signal secretion sequence. FGF-13 is most homologous, 70% similarity at the amino acid level, to FGF-8. Northern hybridization analysis demonstrated prominent expression of FGF-13 in human foetal and adult brain, particularly in the cerebellum and cortex. In proliferation studies with BaF3 cells, FGF-13 preferentially activates cell clones expressing either FGF receptor variant, 3-IIIc or 4. The signal transduction pathways of FGF-13 and FGF-2 were compared in rat hippocampal astrocytes. The two FGFs induce an equivalent level of tyrosine phosphorylation of mitogen-activated protein kinase (MAPK) and c-raf activation. However, FGF-13 is more effective than FGF-2 in inducing the phosphorylation of phospholipase C-gamma (PLC-gamma). Treatment of neuronal cultures from rat embryonic cortex with FGF-13 increases the number of glutamic acid decarboxylase immunopositive neurons, the level of high-affinity gamma-aminobutyric acid (GABA) uptake, and choline acetyltransferase enzyme activity. The GABAergic neuronal response to FGF-13 treatment is rapid with a significant increase occurring within 72 h. We have identified a novel member of the FGF family that is expressed in the central nervous system (CNS) and increases the number as well as the level of phenotypic differentiation of cortical neurons in vitro.
Spirituality and Religion (2010)

Spirituality and Education introduces the basic contours of current debate in a form accessible to both classroom teachers across the curriculum range, and to school managers. It covers all key areas, including:* problems of defining spirituality* government legislation and supporting documentation * relevant empirical research* the social dimension of spirituality* secular and religious manifestations of spirituality in contemporary society* theories of childhood spiritual development* contemporary approaches to spiritual education, including collective worship and cross-curricular teaching. A variety of different perspectives and approaches will be offered, and readers are encouraged to be reflective through a number of tasks which relate all issues raised directly back to their own specific circumstances. The author includes questions, quotes and lists of further reading.
Amine Bis(phenolate) Zirconium Complexes:  Influence of Ligand Structure and Cocatalyst on Copolymerization Behavior (2005)

Five amine bis(phenolate)zirconium dibenzyl complexes, [ONDO]ZrBn2, were investigated in ethylene/1-hexene copolymerization. The copolymerization behavior is sensitive both to the symmetry and connectivity of the ligand framework and to the nature of the cocatalyst. The Cs-symmetric [ONDO]ZrBn2 complexes were more active and exhibited higher comonomer incorporations than the C2-symmetric [ONDO]ZrBn2 complexes. The nature of the cocatalyst was observed to have a significant effect on the amount of hexene incorporated into the copolymers. Activation of the Cs-symmetric [ONDO]ZrBn2 complexes with MMAO yielded copolymers with 10% higher hexene incorporation than that observed upon activation with [PhNMe2H][B(C6F5)4], [B(C6F5)3], or [Ph3C][B(C6F5)4].
Chorea induced by oral contraceptives (1979)

A rare complication of oral contraceptive therapy is the induction of chorea. We here describe five cases of chorea in patients receiving low- or high-dose estrogen-containing contraceptives. All patients were nulliparous, young (average age 19 years), and became symptomatic shortly (average of 5 weeks) after initiation of contraceptive therapy. Two patients previously suffered an episode of Syndenham chorea; one experienced chorea in the course of Henoch-Schönlein purpura; and two had a history of congenital cyanotic heart disease without chorea. Dyskinesia resolved in all patients upon discontinuing the medication. Patients with preexisting striatal abnormalities appear more susceptible to oral contraceptive-induced chorea which is reversible on drug discontinuation. The mechanism of oral contraceptive-induced chorea is unknown, but clinical and experimental data suggest that it involves altered central dopaminergic activity.
Broadband wireless access solutions based on OFDM access in IEEE 802.16 (2002)

Broadband wireless access is the most challenging segment of the wireless revolution since it has to demonstrate a viable alternative to the cable modem and DSL technologies that are strongly entrenched in the last mile access environment. The Analysis, Research, and Consultancy (ARC) Group forecasts that the fixed wireless deployments in both homes and businesses will reach almost 28 million by 2005, with North America and Western Europe accounting for 24 percent and 27 percent of these, respectively. Whether the promise of BWA will materialize depends on its appeal to telecom operators from the perspective of deployment economics, where the critical factor is the ease of installation of broadband wireless subscriber units. This ultimately leads to nonprofessional installation of integrated all-indoor BWSUs. Consequently the physical layer (PHY) has to mitigate the very tough impairments that characterize these non-line-of-sight environments. In this context we overview the work of the one of the IEEE 802.16 standard subcommittee projects that deals with a BWA solution based on OFDM access (OFDMA) aiming at the most challenging NLOS scenarios.
Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation (2009)

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTThrough the "Gatekeeper Door": Exploiting the Active Kinase ConformationFabio Zuccotto*†, Elena Ardini‡, Elena Casale†, and Mauro Angiolini§View Author Information† Department of Chemical Core Technologies‡ Department of Cell Biology Signal Transduction§ Department of Medicinal Chemistry Nerviano Medical Sciences, Oncology, Viale Pasteur 10, Nerviano 20014, Italy*To whom correspondence should be addressed. Phone: +39-0331-581103. Fax: +39-0331-581106. E-mail: [email protected]Cite this: J. Med. Chem. 2010, 53, 7, 2681–2694Publication Date (Web):December 14, 2009Publication History Received29 September 2009Published online14 December 2009Published inissue 8 April 2010https://pubs.acs.org/doi/10.1021/jm901443hhttps://doi.org/10.1021/jm901443hreview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views15387Altmetric-Citations412LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cavities,Inhibitors,Kinase inhibitors,Peptides and proteins,Pharmacophores Get e-Alerts
Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans (2011)

One major expectation from the transcriptome in humans is to characterize the biological basis of associations identified by genome-wide association studies. So far, few cis expression quantitative trait loci (eQTLs) have been reliably related to disease susceptibility. Trans-regulating mechanisms may play a more prominent role in disease susceptibility. We analyzed 12,808 genes detected in at least 5% of circulating monocyte samples from a population-based sample of 1,490 European unrelated subjects. We applied a method of extraction of expression patterns-independent component analysis-to identify sets of co-regulated genes. These patterns were then related to 675,350 SNPs to identify major trans-acting regulators. We detected three genomic regions significantly associated with co-regulated gene modules. Association of these loci with multiple expression traits was replicated in Cardiogenics, an independent study in which expression profiles of monocytes were available in 758 subjects. The locus 12q13 (lead SNP rs11171739), previously identified as a type 1 diabetes locus, was associated with a pattern including two cis eQTLs, RPS26 and SUOX, and 5 trans eQTLs, one of which (MADCAM1) is a potential candidate for mediating T1D susceptibility. The locus 12q24 (lead SNP rs653178), which has demonstrated extensive disease pleiotropy, including type 1 diabetes, hypertension, and celiac disease, was associated to a pattern strongly correlating to blood pressure level. The strongest trans eQTL in this pattern was CRIP1, a known marker of cellular proliferation in cancer. The locus 12q15 (lead SNP rs11177644) was associated with a pattern driven by two cis eQTLs, LYZ and YEATS4, and including 34 trans eQTLs, several of them tumor-related genes. This study shows that a method exploiting the structure of co-expressions among genes can help identify genomic regions involved in trans regulation of sets of genes and can provide clues for understanding the mechanisms linking genome-wide association loci to disease.
High Degree of Interlaboratory Reproducibility of Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Sequencing of Plasma Samples from Heavily Treated Patients (2001)

We assessed the reproducibility of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and protease sequencing using cryopreserved plasma aliquots obtained from 46 heavily treated HIV-1-infected individuals in two laboratories using dideoxynucleotide sequencing. The rates of complete sequence concordance between the two laboratories were 99.1% for the protease sequence and 99.0% for the RT sequence. Approximately 90% of the discordances were partial, defined as one laboratory detecting a mixture and the second laboratory detecting only one of the mixture's components. Only 0.1% of the nucleotides were completely discordant between the two laboratories, and these were significantly more likely to occur in plasma samples with lower plasma HIV-1 RNA levels. Nucleotide mixtures were detected at approximately 1% of the nucleotide positions, and in every case in which one laboratory detected a mixture, the second laboratory either detected the same mixture or detected one of the mixture's components. The high rate of concordance in detecting mixtures and the fact that most discordances between the two laboratories were partial suggest that most discordances were caused by variation in sampling of the HIV-1 quasispecies by PCR rather than by technical errors in the sequencing process itself.
Single-Server Queue System of Shuttle Bus Performance: Federal University of Technology Akure as Case Study (2019)

This study has examined the performance of University transport bus shuttle based on utilization using a Single-server queue system which occur if arrival and service rate is Poisson distributed (single queue) (M/M/1) queue. In the methodology, Single-server queue system was modelled based on Poisson Process with the introduction of Laplace Transform. It is concluded that the performance of University transport bus shuttle is 96.6 percent which indicates a very good performance such that the supply of shuttle bus in FUTA is capable of meeting the demand.
Application of multi‐source waveform inversion to marine streamer data using the global correlation norm (2012)

ABSTRACT Conventional multi‐source waveform inversion using an objective function based on the least‐square misfit cannot be applied to marine streamer acquisition data because of inconsistent acquisition geometries between observed and modelled data. To apply the multi‐source waveform inversion to marine streamer data, we use the global correlation between observed and modelled data as an alternative objective function. The new residual seismogram derived from the global correlation norm attenuates modelled data not supported by the configuration of observed data and thus, can be applied to multi‐source waveform inversion of marine streamer data. We also show that the global correlation norm is theoretically the same as the least‐square norm of the normalized wavefield. To efficiently calculate the gradient, our method employs a back‐propagation algorithm similar to reverse‐time migration based on the adjoint‐state of the wave equation. In numerical examples, the multi‐source waveform inversion using the global correlation norm results in better inversion results for marine streamer acquisition data than the conventional approach.
Restriction endonuclease analysis of four Borrelia burgdorferi strains (1989)

A restriction endonuclease analysis was performed on four strains of Borrelia burgdorferi: one isolated from man (SF), one from Ixodes dammini (B31) and two from I. ricinus (BITS in Italy and B45 in Germany). Digestion by Taq I and Hae III gave the best resolution of the DNA fragments. Three different restriction patterns were obtained: BITS and B45 showed only one band difference. These results correlate with the reactivity of the four strains with monoclonal antibodies.