gebhart/patrepeval huggingface dataset:
Adaptively-Localized-Continuation-Newton: Reservoir Simulation Nonlinear Solvers That Converge All the Time (2009)

Abstract Growing interest in understanding, predicting, and controlling advanced oil recovery methods emphasizes the importance of numerical methods that exploit the nature of the underlying physics. The Fully Implicit Method offers unconditional stability in the sense of discrete approximations. This stability comes at the expense of transferring the inherent physical stiffness onto the coupled nonlinear residual equations which need to be solved at each time-step. Current reservoir simulators apply safe-guarded variants of Newton's method, and often can neither guarantee convergence, nor provide estimates of the relation between convergence rate and time-step size. In practice, time-step chops become necessary, and are guided heuristically. With growing complexity, such as in thermally reactive compositional models, this can lead to substantial losses in computational effort, and prohibitively small time-steps. We establish an alternate class of nonlinear iteration that both converges, and associates a time-step to each iteration. Moreover, the linear solution process within each iteration is performed locally. By casting the nonlinear residual for a given time-step as an initial-value-problem, we formulate a solution process that associates a time-step size with each iteration. Subsequently, no iterations are wasted, and a solution is always attainable. Moreover, we show that the rate of progression is as rapid as a standard Newton counterpart whenever it does converge. Finally, by exploiting the local nature of nonlinear waves that is typical to all multi-phase problems, we establish a linear solution process that performs computation only where necessary. That is, given a linear convergence tolerance, we identify the minimal subset of solution components that will change by more than the specified tolerance. Using this a priori criterion, each linear step solves a reduced system of equations. Several challenging examples are presented, and the results demonstrate the robustness of the proposed method as well as its performance.
TCR Peptide Therapy in Autoimmune Diseases (1993)

Key Words: T cell receptor peptidesautoregulationmyelin basic proteinexperimental encephalomyelitismultiple sclerosis
Host Immune Responses to the Intracellular Bacteria Brucella: Does the Bacteria Instruct the Host to Facilitate Chronic Infection? (2006)

Brucella spp. are intracellular gram-negative bacteria that include a number of virulent species that cause chronic infections in a variety of mammalian hosts. Human infections are proportional to the level of disease in domestic animals because humans are infected zoonotically after contact with infected animals or their products. The chronicity of infection results from the ability of some brucellae to survive reactive oxygen intermediate and nitric oxide killing in host phagocytes, following which they activate bacterial genes in response to the acidic phagosome environment, prevent phagolysosomal fusion by remodeling the intracellular compartment, and subsequently replicate intracellularly. The crucial component of immunity that results in survival of the host and thus maintenance of this chronic infective state is interferon-gamma (IFN-gamma). Production of IFN-gamma results from the ability of brucella components, including lipid A, to interact with Toll-like receptors for the production of IL-12 and TNF-alpha, although the regulatory cytokine IL-10 is also produced and decreases control of the infection. Although CD4 and CD8 T cells are clearly involved in the production of IFN-gamma, and CD8 T cells may be cytotoxic, a role for NK cells and cytotoxicity in protective immunity to brucellosis has not been substantiated experimentally. Moreover, antibodies have been shown to have a limited role in passive transfer studies.
Evaluation of a Computer-Assisted Antibiotic-Dose Monitor (1999)

Many patients experience decreases in renal function after antibiotics are ordered. The use of the computer-assisted antibiotic-dose monitor appears to be a promising method to help reduce the excessive use and cost of antibiotic therapy and reduce the number of ADEs secondary to antibiotics.
[Imidazole H-2 agonists. Synthesis and activity of 2-(2-amino-4-imidazolyl)ethylamine (2-aminohistamine) dihydrochloride]. (1984)

The syntheses of 2-(2-amino-4-imidazolyl)ethylamine (2-aminohistamine) dihydrochloride and of the corresponding 5-methyl derivative are described. The histamine-like properties of the two salts are tested in vitro on isolated ileum and gastric fundus of guinea-pig. The results are discussed and compared with those of other H2-agonists.
Geographical variation mortality from ischaemic heart disease in England and Wales. (1977)

Analysis ofthe proportional mortality attributed to ischaemic heart disease, adjusted for age, reminds us that many of the well known geographical, environmental, social, and economic variations within England and Wales are not disease specific.
Aquaporin-2 (AQP2): its intracellular compartment and trafficking. (2006)

Aquaporins (AQPs) are membrane proteins serving in the transfer of water and small solutes across cellular membranes. At least 7 isoforms, namely AQP1, AQP2, AQP3, AQP4, AQP6, AQP7 and AQP11 are expressed in the kidney. Among them, AQP2 plays a pivotal role in the concentration of urine. AQP2 is expressed in the principal cells of the collecting ducts. It is localized in the intracellular compartment and is translocated to the cell surface upon anti-diuretic hormone stimulation. Analyses in cultured cells expressing AQP2 have provided clues to the trafficking of AQP2. AQP2 resides in the subapical vesicles, some of which are Rab11-positive, suggesting their close relationship with apical recycling endosomes. Upon stimulation with forskolin, AQP2 is translocated to the cell surface. After washout, AQP2 is endocytosed to early endosomes and then transferred to the apical storage compartment. Some of AQP2 is excreted as exosomes. Actin cytoskeleton plays important roles in the trafficking of AQP2. Analyses of molecules found in AQP2-containing vesicles will shed light on the mechanism of AQP2 translocation.
Kinetics and Thermodynamics of Dimer Formation and Dissociation for a Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor (1999)

The recombinant humanized antibody (rhuMAb) VEGF has a high affinity for vascular endothelial growth factor and is currently being evaluated in clinical trials as a cancer therapeutic. Under acidic pH and low ionic strength conditions, the antibody was predominantly present as monomer. Under physiological conditions, the appearance of significant amounts of a noncovalent, reversible dimer were observed by size-exclusion chromatography. The kinetics and thermodynamics of the reversible self-association for rhuMAb VEGF monomer were investigated as a function of pH, temperature, and ionic strength by size-exclusion chromatography using the concentration jump method. The rate constant for dimer formation ranged 23-112 M(-)(1) min(-)(1) under the conditions studied, values that are significantly lower than those reported in the literature for other proteins that self-associate. The rate constant for dissociation ranged 0.0039-0.021 min(-)(1). Gibbs' free energies, enthalpies, entropies, and activation energies were determined and revealed that dimer formation is optimal at pH 7.5-8.0, which may be reflective of charge shielding occurring near the pI of the protein. There was a negative change in entropy for dissociation (values from -18.1 to -12.8 cal/mol K). In the presence of D(2)O or 1 M NaCl, dimerization was enhanced. The results of the kinetic and thermodynamic analysis of this study indicate that rhuMAb VEGF dimerization occurs primarily through hydrophobic interactions.
A Novel Synthesis of 3,3-(Spiro)substituted Azetidines (1994)

A smooth and efficient new synthesis for 3,3-disubstituted azetidines, starting from readily available nitriles, was established: α-hydroxymethylation of the starting materials, followed by O-tosylation and LiAlH 4 -reduction of the key intermediates thus obtained, led ― via spontaneous cyclization of the intermediate amino derivatives ― to 3,3disubstituted azetidines. Scope and limitations of this new method were studied with respect to generalized applicability: the target compounds were accessible in good yields for a variety of starting materials (cyclic and acyclic di(hetero)aryl, (hetero)arylalkyl, dialkyl, as well as basic moieties). The products thus obtained may be of interest for ensuing conversions due to their unblocked nitrogen
Data recovery in IBM Database 2 (1984)

This paper presents the various forms of data recovery provided by IBM Database 2 (DB2). It describes the DB2 recovery log, introduces the notion of a unit of recovery, and discusses the two-phase commit protocol used by DB2. Furthermore, it describes what type of information is logged, the DB2 checkpoint process, what a compensation log record is, and how DB2 handles undo/redo processing, media recovery, restart after abnormal system termination, and data unavailability.
Synthesis and Characterization of Conjugates Formed between Periodate-Oxidized Ribonucleotides and Amine-Containing Fluorophores (1994)

The synthesis and purification of new fluorescently labeled derivatives of GDP and ATP are described. The fluorescent groups are coupled initially through amine-containing linker arms to periodate-oxidized nucleotides. Reduction of the initial product yields primarily a six-membered morpholine-like ring. Fluorescein-labeled GDP, rhodamine-labeled GDP, and fluorescein-labeled ATP were characterized by absorbance spectroscopy and TLC. NMR and FAB-MS studies were carried out on a single nucleotide derivative formed by reacting periodate-oxidized guanosine and benzylamine with subsequent reduction to establish the modification to the ribose moiety. The synthesis of the guanosine-benzylamine conjugate led to a mixture of products that were separated. The predominant product (70%) resulted in conversion of the ribose moiety to a six-membered morpholine-like ring having no hydroxyl group, and the minor product (30%) resulted in an open ring structure having one hydroxyl. When NaCNBH3 was used as the sole reductant, only the product with the morpholine-like ring was formed. These probes were prepared for use in solution studies of the interactions of eukaryotic initiation factor-2 with other components of mammalian protein synthesis initiation.
Determining the Probability of Project Cost Overruns (2012)

The statistical characteristics of cost overruns experienced from contract award in 276 Australian construction and engineering projects were analyzed. The skewness and kurtosis values of the cost overruns are computed to determine if the empirical distribution of the data follows a normal distribution. The Kolmogorov-Smirnov, Anderson-Darling, and chi-squared nonparametric tests are used to determine the goodness of fit of the selected probability distributions. A three-parameter Frechet probability function is found to describe the behavior of cost overruns and provide the best overall distribution fit. The Frechet distribution is then used to calculate the probability of a cost overrun being experienced. The statistical characteristics of contract size and cost overruns were also analyzed. The Cauchy (<A$1 million), Wakeby (A$1 to 10 million, <A$101 million) and four-parameter Burr (A$11 to 50 million) tests were found to provide the best distribution fits and used to calculate cost overrun probabilities by contract size. Ascertaining the best fit probability distribution from an empirical distribution at contract award can produce realistic probabilities of cost overruns, which should then be incorporated into a construction cost contingency.
Planar Lipid Bilayers: Methods and Applications (1994)

Physical Properties of Biological Membranes and Planar Lipid Bilayers. Technical Details of Bilayer Experiments. Biochemical Preparations for Planar Lipid Bilayer Experiments. Methods for Making Planar Lipid Bilayers. Incorporation of Proteins into Planar Lipid Bilayers. Data Acquisition and Evaluation. How to Control the Physical Properties of Planar Lipid Bilayers. Appendix 1. List of Symbols and Abbreviations used. Appendix 2. Letter Code for Amino Acids. Appendix 3. List of Useful Constants, Data and Equations. Appendix 4. Sources of Supply. Appendix 5. Key Reference.
Actuated polysilicon micromirrors for raster-scanning displays (2002)

We have designed and fabricated polysilicon microscanners using surface micromachining technologies. The scanners have electrostatic-comb actuators to drive 300/spl times/400 /spl mu/m/sup 2/ micromirrors mounted on stationary frames by torsion bars. Torsion-bar mounting improves scanning precision from what is achievable using hinge mounting with journal bearings. The scans are accurate to 0.19 mrad; that is a scan jitter of 0.1% of the full scale, or 9% of a pixel. A 7/spl times/10-pixel laser-scanning display built with a 7-element, fan-diode-laser array and a scanning polysilicon micromirror is presented. A dual axis, raster-scanning system based on similar resonant microscanners can be integrated on a chip with the light sources to produce compact microdisplay modules.
Evaluation of recurrent thrombosis and hypercoagulability. (1997)

The primary mechanisms for coagulation were described more than a century ago. However, inherited disorders of coagulation have been recognized for only a few decades. Activated protein C resistance and other related protein defects account for many cases of hypercoagulability. Primary care physicians can initiate testing in individuals for whom there is a high degree of suspicion. Testing for specific disorders is best performed before initiation of anticoagulant therapy. Management often includes long-term warfarin therapy following initial anticoagulation with heparin.
Repeat associated small RNAs vary among parents and following hybridization in maize (2012)

Small RNAs (sRNAs) are hypothesized to contribute to hybrid vigor because they maintain genome integrity, contribute to genetic diversity, and control gene expression. We used Illumina sequencing to assess how sRNA populations vary between two maize inbred lines (B73 and Mo17) and their hybrid. We sampled sRNAs from the seedling shoot apex and the developing ear, two rapidly growing tissues that program the greater growth of maize hybrids. We found that parental differences in siRNAs primarily originate from repeat regions. Although the maize genome contains greater number and complexity of repeats compared with Arabidopsis or rice, we confirmed that, like these simpler plant genomes, 24-nt siRNAs whose abundance differs between maize parents also show a trend of down-regulation following hybridization. Surprisingly, hybrid vigor is fully maintained when 24-nt siRNAs are globally reduced by mutation of the RNA-dependent RNA polymerase 2 encoded by modifier of paramutation1 (mop1). We also discovered that 21-22-nt siRNAs derived from a number of distinct retrotransposon families differentially accumulate between B73 and Mo17 as well as their hybrid. Thus, maize possesses a unique source of genetic variation for regulating transposons and genes at a genomic scale, which may contribute to its high degree of observed heterosis.
Microgastrinomas of the Duodenum (1989)

Gastrinomas are now being detected at an earlier stage than was formerly the case. Furthermore, with the ability to control acid secretion, emphasis has been placed on identifying gastrinoma patients who are potentially curable by tumor resection rather than by palliative gastrectomy. Despites estimates suggesting that 20-40% of sporadic gastrinoma patients can be successfully resected for cure, as many as 40% of such patients have occult tumors that elude detection. In an effort to better localize gastrinomas, we have used percutaneous transhepatic venous (THVS) gastrin sampling over the past 10 years. From 1978 to 1988, THVS was used in 46 patients in whom there was no other evidence of metastatic gastrinoma by conventional studies. Gastrinomas were found at operation in all but one patient. The purpose of this report is to emphasize that occult tumors are most often found in the duodenal wall, and frequently they may be no greater than 2 mm in diameter. Five recent cases illustrate that these small tumors or microgastrinomas may be the sole source of hypergastrinemia and can be cured by local excision. These recent cases emphasize that microgastrinomas are not usually palpable through the duodenal wall. They may be detected only after duodenotomy and meticulous evaluation of the mucosa by eversion and direct palpation. Duodenotomy and intraluminal exploration should be considered an essential component of the operation for patients with extrapancreatic gastrinomas.
Automatic online news issue construction in web environment (2008)

In many cases, rather than a keyword search, people intend to see what is going on through the Internet. Then the integrated comprehensive information on news topics is necessary, which we called news issues, including the background, history, current progress, different opinions and discussions, etc. Traditionally, news issues are manually generated by website editors. It is quite a time-consuming hard work, and hence real-time update is difficult to perform. In this paper, a three-step automatic online algorithm for news issue construction is proposed. The first step is a topic detection process, in which newly appearing stories are clustered into new topic candidates. The second step is a topic tracking process, where those candidates are compared with previous topics, either merged into old ones or generating a new one. In the final step, news issues are constructed by the combination of related topics and updated by the insertion of new topics. An automatic online news issue construction process under practical Web circumstances is simulated to perform news issue construction experiments. F-measure of the best results is either above (topic detection) or close to (topic detection and tracking) 90%. Four news issue construction results are successfully generated in different time granularities: one meets the needs like "what's new", and the other three will answer questions like "what's hot" or "what's going on". Through the proposed algorithm, news issues can be effectively and automatically constructed with real-time update, and lots of human efforts will be released from tedious manual work.
Información de las fases para la planificación de la rentabilidad empresarial (2004)

A study of specialized information as a key to achieving business profitability. The immediate communication of client needs and market fluctuations can lead to the achievement of considerable benefits with minimum difficulty, thereby creating an economic cycle of which intelligent businesses can take advantage and form growth sectors.
Performance evaluation and comparison of Westwood+, New Reno, and Vegas TCP congestion control (2004)

TCP congestion control has been designed to ensure Internet stability along with fair and efficient allocation of the network bandwidth. During the last decade, many congestion control algorithms have been proposed to improve the classic Tahoe/Reno TCP congestion control. This paper aims at evaluating and comparing three control algorithms, which are Westwood+, New Reno and Vegas TCP, using both Ns-2 simulations and live Internet measurements. Simulation scenarios are carefully designed in order to investigate goodput, fairness and friendliness provided by each of the algorithms. Results show that Westwood+ TCP is friendly towards New Reno TCP and improves fairness in bandwidth allocation whereas Vegas TCP is fair but it is not able to grab its bandwidth share when coexisting with Reno or in the presence of reverse traffic because of its RTT-based congestion detection mechanism. Finally results show that Westwood+ remarkably improves utilization of wireless links that are affected by losses not due to congestion.
Phosphorylation of microtubule-associated proteins MAP2a,b and MAP2c at Ser136 by proline-directed kinases in vivo and in vitro. (1994)

The microtubule-associated protein 2 (MAP2) and its juvenile splicing variant MAP2c contain a phosphorylation site at Ser136 which is part of a Ser-Pro motif. This site lies within the N-terminal region common to MAP2b and MAP2c. It has been mapped by site-directed mutagenesis of recombinant MAP2c and by a monoclonal antibody AP18 whose epitope contains the phosphorylated Ser136. In vitro this site is phosphorylated by proline-directed kinases such as MAP kinase, GSK-3, or members of the cdk family, but not by other kinases such as PKA, PKC, or CaMK-II. MAP2a,b or MAP2c isolated from brain is found to be endogenously phosphorylated at Ser136. After microinjection into several cell lines dephosphorylated MAP2 isoforms or recombinant MAP2c become also phosphorylated at Ser136 in vivo. Injection of MAP2a,b or MAP2c into living cells causes reorganization of microtubules, including bundle formation. This effect is independent of the phosphorylation at Ser136. The specificity of the phosphorylation reaction provides a tool for analyzing the role and posttranslational processing of MAP2 in nerve cell development.
Measurement and characterization of broadband MIMO fixed wireless channels at 2.5 GHz (2002)

We study the channel typical for cellular broadband fixed wireless applications. A measurement system for a two-element-transmit by two-element-receive antenna configuration was built, Measurements were conducted in a suburban environment with dual antenna polarization and transmit separation. We present results on K-factor, cross-polarization discrimination (XPD) and Doppler spectrum. Our results address the influence of distance and antenna height for K-factor and XPD. We also comment on the properties of a fixed wireless channel and describe its Doppler spectrum.
Rapid Crystallization and Kinetic Freezing of Site-Disorder in the Lithium Superionic Argyrodite Li6PS5Br (2019)

Lithium argyrodite superionic conductors are currently being investigated as solid electrolytes for all-solid-state batteries. Recently, in the lithium argyrodite Li6PS5X (X = Cl, Br, I), a site-disorder between the anionsS2–and X–has been observed, which strongly affects the ionic transport and appears to be a function of the halide present. In this work, we show how such disorder in Li6PS5Br can be engineered viathe synthesis method. By comparing fast cooling (i.e. quenching) to more slowly cooled samples, we find that anion site-disorder is higher at elevated temperatures, and that fast cooling can be used to kinetically trap the desired disorder, leading to higher ionic conductivities as shown by impedance spectroscopy in combination with ab-initiomolecular dynamics. Furthermore, we observe that after milling, a crystalline lithium argyrodite can be obtained within one minute of heat treatment. This rapid crystallization highlights the reactive nature of mechanical milling and shows that long reaction times with high energy consumption are not needed in this class of materials. The fact that site-disorder induced viaquenching is beneficial for ionic transport provides an additional approach for the optimization and design of lithium superionic conductors.