gebhart/patrepeval huggingface dataset:
Atomic layer etching of 3D structures in silicon: Self-limiting and nonideal reactions (2017)

Current (and future) microelectronics fabrication requirements place unprecedented demands on the fidelity of plasma etching. As device features shrink to atomic dimensions, the plasma etching processes used to define these devices must resolve these scales. By separating etching processes into cycles of multiple, self-limited steps, different physics processes which are closely coupled in traditional plasma etching can be largely decoupled and separately optimized. This technique, atomic layer etching (ALE), can ideally remove uniform layers of material with consistent thickness in each cycle. ALE holds the promise of improving uniformity, reducing damage, increasing selectivity, and minimizing aspect ratio dependent etching (ARDE) rates. The practical implementation of ALE depends on how close to ideal the system can be operated and the tolerance to nonideal conditions. In this paper, results are discussed from a computational investigation of the consequences of nonidealities in the ALE of silicon using Ar/Cl2 plasmas for both two dimensional trenches and three dimensional features. The authors found that ideal ALE requires self-limited processes during all steps of the ALE cycle. Steps that include continuous (non-self-limited) etching reactions reduce the ability of ALE to decouple process parameters. In addition to an etch depth that depends on pulse length per cycle, non-self-limited processes can reintroduce ARDE and produce surface roughening. By controlling subcycle pulse times, these deleterious effects can be minimized, and many of the benefits of ALE can be restored. Even nonideal ALE processes, when properly optimized, still provide benefits over continuous etching with similar chemistries and ion energy distributions. Using fluxes generated by a conventional inductively coupled plasma reactor, an example ALE process is able to clear the corners in a three-dimensional fin based field effect transistor case study with significantly less over-etch than the continuous process.
A low power 10 bit 80 MSPS pipelined ADC in digital CMOS process (2003)

This paper describes a 10 bit 80 MSPS low power ADC designed in a 0.18 /spl mu/m digital CMOS process for an 802.11a baseband PHY chip. The receive channel in the AFE consists of dual ADCs used to digitize the I & Q channels in a direct conversion receiver. Novel features in this design include a 6-bit offset cancellation DAC integrated in the S/H and a amplifier sharing topology that help in reducing overall power and area. Low power is achieved through the use of the digital supply (1.8 V) provided to the chip which allows the fastest digital core transistors to be used in the design without reliability issues and also makes the design suitable for integration with the digital baseband section. Each ADC consumes less than 60 mW of analog power including the reference and about 20 mW of switching power. The device is designed for -62 dB THD performance and 58 dB SNR for an 11 MHz signal band making it among the lowest power ADCs in its class described in literature.
Malarial parasites and tumour cells are killed by the same component of tumour necrosis serum. (1984)

Tumour necrosis serum (TNS), from animals primed with macrophage activating agents and challenged with endotoxin, causes necrosis of some tumours and can kill certain tumour lines in vitro and malarial parasites in vitro and in vivo. We have tested the possibility that the same factor is responsible for killing both tumour cells and malarial parasites. In competitive inhibition experiments, parasitized erythrocytes, but not normal erythrocytes, inhibited the cytotoxicity of TNS against a tumour cell line. Conversely, the tumour cells inhibited the killing of Plasmodium yoelii in vitro by TNS. When rabbit TNS was fractionated by ion exchange chromatography followed by gel filtration and the fractions at each step were pooled according to their ability to kill the tumour cells, in vitro parasite killing activity was found to correlate with tumour cell cytotoxicity, to a final sample which was purified more than 600-fold. Our results suggest that in terms of function, at least, the same component of TNS is responsible for the killing of both tumour cells and malarial parasites.
Pharmacological treatments for restenosis (1997)

Almost two decades after the first percutaneous transluminal coronary angioplasty (PTCA) was performed, restenosis remains the major unmet clinical need in modern interventional cardiology. The identification of clinical candidates has been based, primarily, on data obtained in animal models of restenosis, and has met with frustrating results. Although the failure to identify efficacious agents can, in part, be accounted for by poor experimental design, such a shortfall underlines the paucity of knowledge concerning the precise cellular/molecular mechanisms which drive restenosis. However, recent advances in molecular medicine have facilitated the identification of novel mechanisms involved in the aetiology of restenosis following balloon angioplasty. As a consequence, these discoveries have led to the development of novel therapeutic adjuncts to PTCA which may prove to be of significant clinical utility.
Phase II Trial of Dendritic Cells Loaded with Antigens from Self-Renewing, Proliferating Autologous Tumor Cells as Patient-Specific Antitumor Vaccines in Patients with Metastatic Melanoma: Final Report (2009)

NCI-V01-1646).
Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC (2010)

Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. IFN-λs (also termed IL-28/29) are potent immunomodulatory and antiviral cytokines. We demonstrate that poly IC injection in vivo induces large amounts of IFN-λ, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes. Upon poly IC injection in vivo, the IFN-λ production by splenocytes segregated with cells phenotypically resembling CD8α(+) conventional dendritic cells (DCs [cDCs]). In vitro experiments revealed that CD8α(+) cDCs were the major producers of IFN-λ in response to poly IC, whereas both CD8α(+) cDCs and plasmacytoid DCs produced large amounts of IFN-λ in response to HSV-1 or parapoxvirus. The nature of the stimulus and the cytokine milieu determined whether CD8α(+) cDCs produced IFN-λ or IL-12p70. Human DCs expressing BDCA3 (CD141), which is considered to be the human counterpart of murine CD8α(+) DCs, also produced large amounts of IFN-λ upon poly IC stimulation. Thus, IFN-λ production in response to poly IC is a novel function of mouse CD8α(+) cDCs and their human equivalents.
How many blastomeres of the 4-cell embryo contribute cells to the mouse body? (2001)

The aim of this study was to estimate how many blastomeres of the 4-cell mouse embryo contribute cells to the embryo proper and finally to the animal. To this end, 4-cell embryos of pigmented and albino genotypes were disaggregated and single blastomeres (henceforth called '1/4' or 'quarter' blastomeres) were reaggregated in the following combinations: one 'pigmented' blastomere + three 'albino' blastomeres or vice versa (henceforth called '1+3') and two pigmented blastomeres + two albino blastomeres (henceforth called '2+2'). The aggregations were cultured in vitro and transferred as blastocysts either to the oviduct or uterus of pseudopregnant females. Recipients were allowed to litter naturally, or the foetuses were removed by Caesarian section and raised by lactating foster mothers. Chimaerism was assessed on the basis of coat (adults) or eye pigmentation (dead neonates). Among 28 '1+3' animals, there were 13 chimaeric and 15 non-chimaeric individuals. The pigmentation of non-chimaeras was always concordant with the genotype of the three 1/4 blastomeres and not with the genotype of the single blastomere in the given aggregation. These results make rather unlikely the possibility that the mouse is built of cells derived either from one or all four 1/4 blastomeres. Both two remaining options (2 or 3 1/4 blastomeres) are conceivable but the observed ratio of chimaeras to non-chimaeras among '1+3' animals (13:15) fits better the assumption of two 1/4 blastomeres contributing cells to the animal body. This assumption finds additional support in the observation that among '2+2' animals there were non-chimaeras (5 out of 7) and these would not have been expected should three 1/4 blastomeres contribute cells to the mouse body.
CD24 Expression on T Cells Is Required for Optimal T Cell Proliferation in Lymphopenic Host (2004)

It is well established that T lymphocytes undergo homeostatic proliferation in lymphopenic environment. The homeostatic proliferation requires recognition of the major histocompatibility complex on the host. Recent studies have demonstrated that costimulation-mediated CD28, 4-1BB, and CD40 is not required for T cell homeostatic proliferation. It has been suggested that homeostatic proliferation is costimulation independent. Here, we report that T cells from mice with a targeted mutation of CD24 have a remarkably reduced rate of proliferation when adoptively transferred into syngeneic lymphopenic hosts. The reduced proliferation cannot be attributed to abnormal survival and homing properties of the CD24-deficient T cells. T cell proliferation in allogeneic hosts is less affected by this mutation. These results demonstrate a novel function of CD24 expressed on T cells. Thus, although distinct costimulatory molecules are involved in antigen-driven proliferation and homeostatic proliferation, both processes can be modulated by costimulatory molecules.
T Cell Expression Cloning of a <i>Mycobacterium tuberculosis</i> Gene Encoding a Protective Antigen Associated with the Early Control of Infection (2000)

Infection of C57BL/6 mice with Mycobacterium tuberculosis results in the development of a progressive disease during the first 2 wk after challenge. Thereafter, the disease is controlled by the emergence of protective T cells. We have used this infection model in conjunction with direct T cell expression cloning to identify Ags involved with the early control of the disease. A protective M. tuberculosis-specific CD4 T cell line derived from mice at 3 wk postchallenge was used to directly screen an M. tuberculosis genomic expression library. This screen resulted in the identification of a genomic clone comprising two putative adjacent genes with predicted open reading frames of 10 and 41 kDa, MTB10 and MTB41, respectively (the products of Rv0916c and Rv0915c, respectively, in the TubercuList H37Rv database). MTB10 and MTB41 belong to the PE and PPE family of proteins recently identified to comprise 10% of the M. tuberculosis genome. Evaluation of the recombinant proteins revealed that MTB41, but not MTB10, is the Ag recognized by the cell line and by M. tuberculosis-sensitized human PBMC. Moreover, C57BL/6 mice immunized with MTB41 DNA developed both CD4- (predominantly Th1) and CD8-specific T cell responses to rMTB41 protein. More importantly, immunization of C57BL/6 mice with MTB41 DNA induced protection against infection with M. tuberculosis comparable to that induced by bacillus Calmette-Guérin. Thus, the use of a proven protective T cell line in conjunction with the T cell expression cloning approach resulted in the identification of a candidate Ag for a subunit vaccine against tuberculosis.
Coherence preservation in multi-channel Wiener filtering based noise reduction for binaural hearing aids (2013)

Besides noise reduction an important objective of binaural speech enhancement algorithms is the preservation of the binaural cues, i.e. the Interaural Level Difference and the Interaural Time Difference of all sound sources. Recently, extensions of the binaural Multi-channel Wiener filter (MWF) have been presented, which aim to preserve the binaural cues of the residual noise component. However, since these algorithms aim to preserve the Interaural Transfer Function (ITF), they are well-suited only for directional noise sources but not for, e.g. spatially isotropic noise, which can not be fully described by the ITF. In this paper, we present an extension of the binaural MWF, aiming to preserve the Interaural Coherence of the residual noise component. Experimental results using spatially isotropic noise show that the proposed algorithm yields a good preservation of the Interaural Coherence without significantly degrading the output SNR compared to the binaural MWF and the binaural MWF with ITF preservation.
Measuring disease-specific quality of life in clinical trials. (1986)

While measurement of quality of life is a vital part of assessing the effect of treatment in many clinical trials, a measure that is responsive to clinically important change is often unavailable. Investigators are therefore faced with the challenge of constructing an index for a specific condition or even for a single trial. There are several stages in the development and testing of a quality-of-life measure: selecting an initial item pool, choosing the "best" items from that pool, deciding on questionnaire format, pretesting the instrument, and demonstrating the responsiveness and validity of the instrument. At each stage the investigator must choose between a rigorous, time-consuming approach to questionnaire construction that will establish the clinical relevance, responsiveness and validity of the instrument and a more efficient, less costly strategy that leaves reproducibility, responsiveness and validity untested. This article describes these options and outlines a pragmatic approach that yields consistently satisfactory disease-specific measures of quality of life.
Supramolecular templating in thermodynamically controlled synthesis (2002)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Development of a new synthesis of 3‐(1<i>H</i>‐tetrazol‐5‐yl)‐4(3<i>H</i>)‐quinazolinone, sodium salt <i>via</i> an amidine intermediate (1989)

Abstract A new synthesis of the recently reported 3‐(1 H ‐tetrazol‐5‐yl)‐4(3 H )‐quinazolinone, sodium salt ( 1 , MDL‐427), an experimental mediator release inhibitor, was developed from: (1) reaction of 5‐aminotetrazole 3 and triethyl orthoformate 6 to give ethyl N ‐(1 H ‐tetrazol‐5‐yl)formimidate 8 , (2) reaction of methyl anthranilate and imidate 8 to give amidine 11 , and (3) treatment of 11 with base to give 1 . Investigation of each of these steps independently led to a significantly more efficient, facile and higher‐yielding 1‐pot process. A brief examination of anthranilic acid 13 and its salts and derivatives 14 to 17 in this process found them to have dissimilar reactivities. The formation of amidine 11 as an isolable intermediate was unusual, as was its failure to cyclize under standard neutral or acidic conditions. The absolute requirement for base to effect cyclization of 11 appears to be unprecedented.
Mycelium Composites: A Review of Engineering Characteristics and Growth Kinetics (2017)

Mycelium composites comprise of networks of filamentous hyphae, utilising biological growth rather than expensive energy intensive manufacturing processes to convert low-cost organic wastes into economically viable and environmentally friendly materials. Although generally characterised as polymer grade foams and used primarily for limited packaging and construction applications, the mechanical performance of these materials varies significantly and is governed by hyphal architecture, cell wall composition, composite constituents and growth kinetics which are in turn influenced by inherent and exogenous factors. A range of potential applications have been proposed including acoustic dampers, super absorbents, paper, textiles, structural and electronic parts. Limited research, inconclusive data and the proposed applications and feasibility suggest that further investigation is warranted.
A study of the structure of hydrazones of indole-2,3-dione and 1-methylindole-2,3-dione with nuclear magnetic resonance spectroscopy (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA study of the structure of hydrazones of indole-2,3-dione and 1-methylindole-2,3-dione with nuclear magnetic resonance spectroscopyFred A. Snavely and Sun UnCite this: J. Org. Chem. 1981, 46, 13, 2764–2766Publication Date (Print):June 1, 1981Publication History Published online1 May 2002Published inissue 1 June 1981https://pubs.acs.org/doi/10.1021/jo00326a032https://doi.org/10.1021/jo00326a032research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Image Guided Biodistribution and Pharmacokinetic Studies of Theranostics (2012)

Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems in various diseases, especially cancers. Besides anatomical imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), molecular imaging strategy including optical imaging, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) will facilitate the localization and quantization of radioisotope or optical probe labeled nanoparticle delivery systems in the category of theranostics. The quantitative measurement of the bio-distribution and pharmacokinetics of theranostics in the fields of new drug/probe development, diagnosis and treatment process monitoring as well as tracking the brain-blood-barrier (BBB) breaking through by high sensitive imaging method, and the applications of the representative imaging modalities are summarized in this review.
Effects of Football Collars on Cervical Hyperextension and Lateral Flexion. (2003)

OBJECTIVES: To evaluate the effectiveness of 3 football collars in reducing cervical range of motion. DESIGN AND SETTING: A repeated-measures design in a controlled laboratory setting. SUBJECTS: Fifteen male National Collegiate Athletic Association Division I varsity football athletes. MEASUREMENTS: Cervical hyperextension and lateral flexion were measured with video analysis. Subjects underwent 5 testing conditions: standard football helmet, standard helmet and shoulder pads, and standard pads with the addition of the Cowboy Collar, A-Force Neck Collar, or a foam neck roll. Subjects performed motions both actively and passively. RESULTS: All 3 collars reduced hyperextension when compared with the helmet and shoulder pads alone (P <.05); in addition, the Cowboy Collar was superior to the foam neck roll (P <.05) in reducing hyperextension. No collar reduced passive lateral flexion when compared with the helmet and shoulder pads, but the foam neck roll permitted significantly less active lateral flexion (P <.01) than the other 3 brace conditions. CONCLUSIONS: In a laboratory setting, cervical hyperextension can be controlled through the use of various cervical collars. Cervical lateral flexion (a more common cause of burners in a scholastic population) cannot be controlled with any of the cervical collars tested. Moreover, foam collars may impede active lateral flexion while not providing additional protection when loaded. These results are limited in that they were produced in a controlled situation as opposed to active football play.
THE COURSE AND TREATMENT OF LUPUS NEPHRITIS (1994)

Renal involvement by systemic lupus is variable; some patients have minimal clinical and histologic involvement, whereas others have fulminant renal failure and severe proliferative renal lesions on biopsy. The World Health Organization (WHO) classification has greatly aided in the study of lupus nephritis. This classification defines six major patterns of renal involvement, each with characteristic clinical correlates and a typical course and prognosis. Transformations from one pattern of lupus nephritis to another may occur, and there may also be prominent involvement of the tubulointerstitial compartment and vasculature. Treatment of the renal lesions may be directed at the individual class of lupus nephritis. Thus patients with mesangial involvement (WHO Class II) do not require therapy directed at their kidney lesions. Many patients with biopsies showing focal proliferative disease (WHO Class III) and all patients whose biopsies show diffuse proliferative lesions (WHO Class IV) require vigorous treatment, which has included high-dose daily and alternate-day corticosteroids, azathioprine, i.v. pulse methylprednisolone, plasmapheresis, total lymphoid irradiation, cyclosporine, and oral and i.v. cyclophosphamide. Controlled trials have yielded reasonable evidence for the safety and efficacy of some treatments, whereas others have been used only in uncontrolled studies. When used judiciously, such vigorous therapy can improve the renal survival of patients with severe lupus nephritis.
Authorization policy in a PKI environment (2002)

The major emphasis of Public Key Infrastructure has been to provide a cryptographically secure means of authenticating identities. While there are a number of proposed standards for authorization structures and protocols based on X.509 or other key-based identities, none have been widely adopted. As part of an effort to use X.509 identities to provide authorization in highly distributed environments, we have developed and deployed an authorization service based on X.509 identified users and access policy contained in certificates signed by X.509 identified stakeholders. The major goal of this system, called Akenti, is to produce a usable authorization system for an environment consisting of distributed resources used by geographically and administratively distributed users.
A Convenient Method for the Preparation of Ketones by the Reaction of Grignard Reagents with Carboxylic Acid Derivatives (1974)

Abstract It was found that ketones were prepared in excellent yields by the reaction of Grignard reagents with S-(2-pyridyl) thioates and their analogues or with 2-pyridyl esters. The mechanism of this reaction was also discussed. This useful method for the preparation of ketones was successfully applied to the syntheses of cis-jasmone and dihydrojasmone.