gebhart/patrepeval huggingface dataset:
Reversible <i>n</i>-Doping of Poly(nonylbithiazole) and Oligomeric Model Compounds. Application as a Li Battery Electrode (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTReversible n-Doping of Poly(nonylbithiazole) and Oligomeric Model Compounds. Application as a Li Battery ElectrodeM. David Curtis, Haitao Cheng, John I. Nanos, and G.-Abbas NazriView Author Information Willard H. Dow Laboratory, Department of Chemistry, and the Macromolecular Science and Engineering Center, The University of Michigan, Ann Arbor, Michigan 48109-1055 Physics and Physical Chemistry Department, General Motors Research and Development Center, 30500 Mound Road, Warren, Michigan 48090-9055 Cite this: Macromolecules 1998, 31, 1, 205–207Publication Date (Web):January 13, 1998Publication History Received26 August 1997Revised14 November 1997Published online13 January 1998Published inissue 1 January 1998https://pubs.acs.org/doi/10.1021/ma971285bhttps://doi.org/10.1021/ma971285brapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views248Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Electrodes,Oligomers,Polymer films,Polymers,Redox reactions Get e-Alerts
Auditory cortex asymmetry, altered minicolumn spacing and absence of ageing effects in schizophrenia (2008)

The superior temporal gyrus, which contains the auditory cortex, including the planum temporale, is the most consistently altered neocortical structure in schizophrenia (Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophr Res 2001; 49: 1-52). Auditory hallucinations are associated with abnormalities in this region and activation in Heschl's gyrus. Our review of 34 MRI and 5 post-mortem studies of planum temporale reveals that half of those measuring region size reported a change in schizophrenia, usually consistent with a reduction in the left hemisphere and a relative increase in the right hemisphere. Furthermore, female subjects are under-represented in the literature and insight from sex differences may be lost. Here we present evidence from post-mortem brain (N = 21 patients, compared with 17 previously reported controls) that normal age-associated changes in planum temporale are not found in schizophrenia. These age-associated differences are reported in an adult population (age range 29-90 years) and were not found in the primary auditory cortex of Heschl's gyrus, indicating that they are selective to the more plastic regions of association cortex involved in cognition. Areas and volumes of Heschl's gyrus and planum temporale and the separation of the minicolumns that are held to be the structural units of the cerebral cortex were assessed in patients. Minicolumn distribution in planum temporale and Heschl's gyrus was assessed on Nissl-stained sections by semi-automated microscope image analysis. The cortical surface area of planum temporale in the left hemisphere (usually asymmetrically larger) was positively correlated with its constituent minicolumn spacing in patients and controls. Surface area asymmetry of planum temporale was reduced in patients with schizophrenia by a reduction in the left hemisphere (F = 7.7, df 1,32, P < 0.01). The relationship between cortical asymmetry and the connecting, interhemispheric callosal white matter was also investigated; minicolumn asymmetry of both Heschl's gyrus and planum temporale was correlated with axon number in the wrong subregions of the corpus callosum in patients. The spacing of minicolumns was altered in a sex-dependent manner due to the absence of age-related minicolumn thinning in schizophrenia. This is interpreted as a failure of adult neuroplasticity that maintains neuropil space. The arrested capacity to absorb anomalous events and cognitive demands may confer vulnerability to schizophrenic symptoms when adult neuroplastic demands are not met.
OPC-21268, an Orally Effective, Nonpeptide Vasopressin V1 Receptor Antagonist (1991)

An orally effective, nonpeptide, vasopressin V1 receptor antagonist, OPC-21268, has been identified. This compound selectively antagonized binding to the V1 subtype of the vasopressin receptor in a competitive manner. In vivo, the compound acted as a specific antagonist of arginine vasopressin (AVP)-induced vasoconstriction. After oral administration in conscious rats, the compound also antagonized pressor responses to AVP. OPC-21268 can be used to study the physiological role of AVP and may be therapeutically useful in the treatment of hypertension and congestive heart failure.
Hierarchical Sequence to Sequence Voice Conversion with Limited Data (2019)

We present a voice conversion solution using recurrent sequence to sequence modeling for DNNs. Our solution takes advantage of recent advances in attention based modeling in the fields of Neural Machine Translation (NMT), Text-to-Speech (TTS) and Automatic Speech Recognition (ASR). The problem consists of converting between voices in a parallel setting when {\it $$} audio pairs are available. Our seq2seq architecture makes use of a hierarchical encoder to summarize input audio frames. On the decoder side, we use an attention based architecture used in recent TTS works. Since there is a dearth of large multispeaker voice conversion databases needed for training DNNs, we resort to training the network with a large single speaker dataset as an autoencoder. This is then adapted for the smaller multispeaker voice conversion datasets available for voice conversion. In contrast with other voice conversion works that use $F_0$, duration and linguistic features, our system uses mel spectrograms as the audio representation. Output mel frames are converted back to audio using a wavenet vocoder.
Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF (2000)

Using a rat model of ischemia/reperfusion injury, we demonstrate here that HGF is cardioprotective due to its antiapoptotic effect on cardiomyocytes. Following transient myocardial ischemia and reperfusion, c-Met/HGF receptor expression rapidly increased in the ischemic myocardium, an event accompanied by a dramatic increase in plasma HGF levels in the infarcted rats. When endogenous HGF was neutralized with a specific antibody, the number of myocyte cell deaths increased markedly, the infarct area expanded, and the mortality increased to 50%, as compared with a control group in which there was no mortality. Plasma from the myocardial infarcted rats had cardioprotective effects on primary cultured cardiomyocytes, but these effects were significantly diminished by neutralizing HGF. In contrast, recombinant HGF administration reduced the size of infarct area and improved cardiac function by suppressing apoptosis in cardiomyocytes. HGF rapidly augmented Bcl-xL expression in injured cardiomyocytes both in vitro and in vivo. As apoptosis of cardiomyocytes is one of the major contributors to the pathogenesis in subjects with ischemia/reperfusion injury, prevention of apoptosis may prove to be a reasonable therapeutic strategy. Supplements of HGF, an endogenous cardioprotective factor, may be found clinically suitable in treating subjects with myocardial infarction.
Manipulation of combustion waves in carbon-nanotube/fuel composites by highly reactive Mg nanoparticles (2015)

Manipulating the interface of micro/nanostructured materials and chemical fuels can change the fundamental characteristics of combustion waves that are generated during a reaction. In this study, we report that Mg/MgO nanoparticles actively amplify the propagation of combustion waves at the interface of multi-walled carbon nanotubes (MWCNTs) and chemical fuels. Fuel/MWCNT and fuel/MWCNT-Mg/MgO composite films were prepared by a facile synthetic method. We present complete physiochemical characterization of these composite films and evaluate the propagating velocities and real-time surface temperatures of combustion waves. Mg/MgO nanoparticles at the interface enhanced the reaction front velocity by 41%. The resulting explosive reactions supplied additional thermal energy to the chemical fuel, accelerating flame propagation. Furthermore, the surface temperatures of the composites with Mg/MgO nanoparticles were much lower, indicating how the transient heat from the reaction would ignite the unreacted fuels at lower surface temperatures despite not reaching the necessary activation energy for a chain reaction. This mechanism contributed to thermopower waves that amplified the output voltage. Furthermore, large temperature gradients due to the presence of nanoparticles increased charge transport inside the nanostructured material, due to the increased thermoelectric effects. This manipulation could contribute to the active control of interfacially driven combustion waves along nanostructured materials, yielding many potential applications.
Isotropic Remeshing of Surfaces: a Local Parameterization Approach (2003)

We present a method for isotropic remeshing of arbitrary genus surfaces. The method is based on a mesh adaptation process, namely, a sequence of local modifications performed on a copy of the original mesh, while referring to the original mesh geometry. The algorithm has three stages. In the first stage the required number or vertices are generated by iterative simplification or refinement. The second stage performs an initial vertex partition using an area-based relaxation method. The third stage achieves precise isotropic vertex sampling prescribed by a given density function on the mesh. We use a modification of Lloyd’s relaxation method to construct a weighted centroidal Voronoi tessellation of the mesh. We apply these iterations locally on small patches of the mesh that are parameterized into the 2D plane. This allows us to handle arbitrary complex meshes with any genus and any number of boundaries. The efficiency and the accuracy of the remeshing process is achieved using a patch-wise parameterization technique.
Effect of alpha-Tocopherol on Hepatocarcinogenesis in Transforming Growth Factor-alpha (TGF-alpha) Transgenic Mice Treated with Diethylnitrosamine (2001)

To examine the potentially chemopreventive effects of alpha-tocopherol on hepatocarcinogenesis, we fed the transgenic mice line MT42, which overexpresses transforming growth factor-alpha (TGF-alpha) and which has been established as having a high incidence of liver tumor, with different concentrations of alpha-tocopherol and examined the hepatic tumorigenesis of these mice. At 3 weeks of age, MT42 male mice received a single intraperitoneal injection of diethylnitrosamine (DEN), 5 mg/kg body weight, to initiate the formation of liver tumors. The mice were divided into three groups: group A, control diet (20 mg/kg of alpha-tocopherylacetate); group B, deficient diet (less than 1 mg/kg); group C, supplemented diet (500 mg/kg). Neoplastic change was determined at 40 weeks of age. The incidence of adenomas (p < 0.05), the maximum tumor size (p < 0.01), the mean relative liver weight (p < 0.01), and the proliferating cell nuclear antigen (PCNA) labeling indices of the non-tumor sites (p < 0.01) of group B were significantly higher than those of group C. No toxic effects of alpha-tocopherol were found. Alpha-tocopherol-deficient diet accelerated the hepatocarcinogenesis of TGF-alpha transgenic mice treated with DEN. At best, these data demonstrate that alpha-tocopherol-deficiency is not beneficial for prevention of hepatocarcinogenesis in this model. Alpha-tocopherol may be useful for the chemoprevention for liver cancer.
Pharmacodynamics, Efficacy, and Safety of IPX203 in Parkinson Disease Patients With Motor Fluctuations (2019)

IPX203 demonstrated a sustained effect to reduce Off time and improve Good On time in patients with PD and motor fluctuations. Both treatments were well tolerated.
Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin. (1981)

We have constructed and cloned in bacteria recombinant DNA molecules containing DNA sequences coding for the precursor of the alpha subunit of thyrotropin (pre-TSH-alpha). Double-stranded DNA complementary to total poly(A)+RNA derived from a mouse pituitary thyrotropic tumor was prepared enzymatically, inserted into the Pst I site of the plasmid pBR322 by using poly(dC).poly(dG) homopolymeric extensions, and cloned in Escherichia coli chi 1776. Cloned cDNAs encoding pre-TSH-alpha were identified by their hybridization to pre-TSH-alpha mRNA as determined by cell-free translations of hybrid-selected and hybrid-arrested RNA. The nucleotide sequences of two cDNAs (510 and 480 base pairs) were determined with chemical methods and corresponded to much of the region coding for the alpha subunit and the 3' untranslated region of pre-TSH-alpha mRNA. The sequence of the 5' end of the mRNA was determined from cDNA synthesized by using total mRNA as template and a restriction enzyme DNA fragment as primer. Together these sequences represented greater than 90% of the coding and noncoding regions of full-length pre-TSH-alpha mRNA, which was determined to be 800 bases long. The amino acid sequence of the pre-TSH-alpha deduced from the nucleotide sequence showed a NH2-terminal leader sequence of 24 amino acids followed by the 96-amino-acid sequence of the apoprotein of TSH-alpha. There is greater than 90% homology in the amino acid sequences among the murine, ruminant, and porcine alpha subunits and 75-80% homology among the murine, equine, and human alpha subunits. Several regions of the sequence remain absolutely conserved among all species, suggesting that these particular regions are essential for the biological function of the subunit. The successful cloning of the alpha subunit of TSH will permit further studies of the organization of the genes coding for the glycoprotein hormone subunits and the regulation of their expression.
Abietane Diterpenoids from the Bark of <i>Cryptomeria fortunei</i> (2008)

Four new abietane diterpenoids, fortunins A-D (1-4), and six new 18-hydroxymethylene abietane diterpenoids, fortunins E-J (5-10), along with 12 known diterpenoids, were isolated from the bark of Cryptomeria fortunei. The structures of new compounds were established on the basis of 1D and 2D NMR and other spectroscopic analyses.
ChemInform Abstract: The Ternary Thorium Aluminum Carbides Th2Al2C3 and ThAl4C4. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Novel monoclonal antibodies targeting the microtubule-binding domain of human tau (2018)

Tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau. The tau pathology burden correlates with neurodegeneration and dementia observed in these diseases. The microtubule binding domain of tau is essential for its physiological functions in promoting neuronal cytoskeletal stability, however it is also required for tau to assemble into an amyloid structure that comprises pathological inclusions. A series of novel monoclonal antibodies were generated which recognize the second and fourth microtubule-binding repeat domain of tau, thus enabling the identification specifically of 4-repeat tau versus 3-/4-repeat tau, respectively. These antibodies are highly specific for tau and recognize pathological tau inclusions in human tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy and in transgenic mouse models of tauopathies. These new antibodies will be useful for identifying and characterizing different tauopathies and as tools to target tau pathology in these diseases.
Components of Congestion: Delay from Incidents, Special Events, Lane Closures, Weather, Potential Ramp Metering Gain, and Excess Demand (2006)

A method is presented to divide the total congestion delay in a freeway section into six components: the delay caused by incidents, special events, lane closures, and adverse weather; the potential reduction in delay at bottlenecks that ideal ramp metering can achieve; and the remaining delay, caused mainly by excess demand. The fully automated method involves two steps. First, the components of nonrecurrent congestion are estimated by statistical regression. Second, the method locates all bottlenecks and estimates the potential reduction in delay that ideal ramp metering can achieve. The method can be applied to any site with minimum calibration. It requires data about traffic volume and speed; the time and location of incidents, special events, and lane closures; and adverse weather. Applied to a 45-mi section of I-880 in the San Francisco Bay Area in California, the method reveals that incidents, special events, rain, potential reduction by ideal ramp metering, and excess demand respectively account for 13.3%, 4.5%, 1.6%, 33.2%, and 47.4%, respectively, of the total daily delay. The delay distribution of the various components is different between the morning and evening peak periods and between the two freeway directions. Quantifying the components of congestion at individual freeway sites is essential for developing effective congestion mitigation strategies.
Learning to compare image patches via convolutional neural networks (2015)

In this paper we show how to learn directly from image data (i.e., without resorting to manually-designed features) a general similarity function for comparing image patches, which is a task of fundamental importance for many computer vision problems. To encode such a function, we opt for a CNN-based model that is trained to account for a wide variety of changes in image appearance. To that end, we explore and study multiple neural network architectures, which are specifically adapted to this task. We show that such an approach can significantly outperform the state-of-the-art on several problems and benchmark datasets.
Nestin, PDGFR-β, CXCL12 and VEGF in gliomapatients: Different profiles of (Pro-Angiogenic) molecule expression are related with tumor grade and may provide prognostic information (2007)

Angiogenesis is a key event in the natural progression of gliomas. Nestin, a marker for multipotential neuroepithelial stem cells, is detected in neuroepithelial tumors and in proliferating endothelial cells (ECs) and is involved in the early stages of lineage commitment, proliferation and differentiation. Nestin expression is correlated with proangiogenic chemokines (CXCL12 and its receptor CXCR4) and growth factors (VEGF, PDGF-B and its receptor PDGFRbeta). VEGF expression upregulates CXCR4 on endothelial cells, binding the chemokine SDF1/CXCL12 (Stromal Derived Factor) that has a role on angiogenesis and chemotaxis of endothelial cells; PDGF (platelet-derived growth factor) and PDGFRbeta are also crucial by increasing the expression of VEGF. We performed a retrospective study on the presence and role of nestin-expressing cells in 102 patients with glioma, relating the findings to VEGF, CXCL12, PDGFRbeta expression and to clinical outcome (time to tumor progression-TTP and survival time-ST). Our results suggest that in gliomas the detection of proliferating ECs expressing nestin correlates to histological malignancy grade and clinical outcome. Also, the expression of CXCL12 in low-grade gliomas was the only factor associated with a significantly shorter TTP, suggesting a role of this chemokine in angiogenic shift and/or disease progression.
Therapeutic potential of synthetic triterpenoids in neuroblastoma (2008)

Commentary to:Human Neuroblastoma Cells Rapidly Enter Cell Cycle Arrest and Apoptosis Following Exposure to C-28 derivatives of the Synthetic Triterpenoid CDDOJennifer Alabran, Adam Cheuk, Karen Liby, Michael Sporn, Javed Khan, John Letterio and Konstantin S Leskov
Current Accelerators for Research and Industry (1981)

In this paper we will describe four ongoing accelerator projects at Instrument AB Scanditronix in Uppsala, Sweden. These projects are being pursued in addition to the standard product lines of cyclotrons, microtrons, and magnetic spectrographs of Scanditronix and its U. S. affiliate, Nucletronix, rnc., in Gloucester, Massachusetts. These projects are as follows: 1. The BESSY electron storage ring synchrotron radiation project in Berlin, West Germany 2. The spallation neutron source project at KFA, Julich and KFE, Karlsruhe, West Germany 3. The NT50 clinical neutron therapy project at the University of Washington in Seattle, Washington 4. The RNP16 radionuclide production system at Johns Hopkins University Hospital in Baltimore, Maryland
Cloning and Characterization of PRAX-1 (1999)

Using a cytoplasmic domain of the peripheral benzodiazepine receptor (PBR) as a bait in the yeast two-hybrid system, we have isolated a cDNA encoding a new protein that specifically interacts with PBR. We named it PRAX-1, for peripheral benzodiazepine receptor-associated protein 1. PRAX-1 is a 1857-amino acid protein, the sequence of which was structurally unrelated to any known proteins. The gene encoding PRAX-1 is located in the q22-q23 region of the long arm of the human chromosome 17. The PRAX-1 mRNA is 7.5 kilobase pairs, predominantly expressed in the central nervous system, pituitary gland, and thymus. At the protein level, we found the PRAX-1 as a single 220-250-kDa protein in the brain and in many different human cell lines tested using specific antibody raised against PRAX-1. Parallel analysis of the PRAX-1 mRNA and protein expression performed in mouse and rat gave similar results. Immunocytochemistry analysis carried out to define the distribution of the PRAX-1 protein in the rat brain showed that PRAX-1 was prevalent in the mesolimbic system, specially abundant in the CA1 subfield of the hippocampus. Exhibiting several domains involved in protein-protein interaction (three proline-rich domains, three leucine-zipper motifs, and an Src homology region 3-like domain), the PRAX-1 may be looked upon as a new adaptator protein. We show that both the Src homology region 3-like domain and a proline-rich domain in PRAX-1 are required for the interaction with PBR. PRAX-1 is a cytoplasmic protein that also partially colocalizes with PBR in the mitochondria, as determined by confocal microscopy and Western blotting. Altogether our observations support a model of interaction implicating PBR and this newly described protein, PRAX-1. As being the first cytoplasmic protein associated with PBR, PRAX-1 is a new tool that opens new fields for exploring PBR biological roles.