gebhart/patrepeval huggingface dataset:
CREATE-LIFE: a modular design approach for high performance ASICs (2002)

CREATE-LIFE (Compiler for REgular ArchiTEcture, Long Instruction Format Engine) is an architecture-specific design approach for CMOS VLSI based on block modularity and architecture regularity. It takes as input a description of the function to be performed by a VLSI circuit using general-purpose. Pascal-like programming language and a description of the particular LIFE architecture instance. The output is the CMOS layout of a very high-performance (micro) programmed architecture tailored for that specific function. The LIFE architectures generated in the design environment are the single-chip implementations of an improved form of a very long instruction work (VLIW) architecture that uses both parallelism and pipelining. With this approach, an experimental general-purpose processor which performs in the 50 to 100 VAX equivalent range has been designed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
CHD1 Motor Protein Is Required for Deposition of Histone Variant H3.3 into Chromatin in Vivo (2007)

The organization of chromatin affects all aspects of nuclear DNA metabolism in eukaryotes. H3.3 is an evolutionarily conserved histone variant and a key substrate for replication-independent chromatin assembly. Elimination of chromatin remodeling factor CHD1 in Drosophila embryos abolishes incorporation of H3.3 into the male pronucleus, renders the paternal genome unable to participate in zygotic mitoses, and leads to the development of haploid embryos. Furthermore, CHD1, but not ISWI, interacts with HIRA in cytoplasmic extracts. Our findings establish CHD1 as a major factor in replacement histone metabolism in the nucleus and reveal a critical role for CHD1 in the earliest developmental instances of genome-scale, replication-independent nucleosome assembly. Furthermore, our results point to the general requirement of adenosine triphosphate (ATP)-utilizing motor proteins for histone deposition in vivo.
Immune responses in patients with T-cell lymphoma treated with an anti-idiotype antibody mimicking a highly restricted T-cell antigen. (1995)

We generated an IgG1 murine monoclonal anti-idiotype antibody (Ab2) to a highly restricted T-cell antigen designated glycoprotein (gp) 37 that is found on T-cell malignancies but not on normal cells. gp37 is identified by the murine monoclonal antibody SN2 (Ab1) against which the Ab2 was raised. Each of four patients with T-cell lymphoma predominantly confined to the skin received a minimum of four intracutaneous injections of aluminum hydroxide precipitated anti-idiotype murine monoclonal antibody (1 mg/injection) given every 2 weeks. For responding patients, injections were continued on a monthly basis. All tumors were measured along orthogonal major and minor axes, using a ruler and/or calipers, by the same observer. Tumor sizes were documented photographically. Three of the four patients developed specific idiotypic humoral immune responses, and two of the four patients also demonstrated idiotypic cell-mediated responses. Humoral responses included binding of the patients' sera to the anti-idiotype antibody as well as specific inhibition of binding of the SN2 antibody (Ab1) to the anti-idiotype antibody (Ab2). Anti-anti-idiotypic (Ab3) antibody from one patient's serum bound specifically to the gp37-positive cell line MOLT-4 and also to semipurified gp37 antigen. Cell-mediated responses were demonstrated by specific proliferative response to the aluminum hydroxide precipitated anti-idiotype antibody by patients' peripheral blood mononuclear cells. While three of the four patients had extensive disease and did not have clinical responses, one of the patients who had nine discrete skin tumors and peripheral blood involvement without other detectable disease had virtually complete disappearance of the tumors lasting over 11 months. Our results demonstrate that this particular anti-idiotype antibody can induce humoral and cellular immune responses, and at least in one patient led to a meaningful therapeutic response. Future trials should focus on immunocompetent patients with minimal disease.
Evaluation of Liquid or Powdered Fortification of Human Milk on Growth and Bone Mineralization Status of Preterm Infants (1992)

Thirty-five preterm (< 1500 g) infants were fed preterm human milk (PHM) supplemented with either powdered fortifier (PF) or liquid supplement (LS). Bone mineral content (BMC) of the distal third radius was measured by photon absorptiometry. Biochemical indices of nutritional and bone status were obtained every 2 weeks. The initial BMC for both feeding regimens were similar. BMC did not change over the study period for infants fed LS. Infants fed PF had BMC values greater than LS infants at weeks 2 and 4 of study. Only infants fed PF had BMC values that demonstrated a consistent increase. Serum total protein and phosphorus values were greater for PF infants at week 4 than LS infants. Weight, length, occipital-frontal circumference (OFC) gains, serum albumin, alkaline phosphatase, calcium, and vitamin D levels were similar in both groups. We conclude that products used to "enrich" PHM are adequate to meet the growth needs of the preterm infant. However, we found that infants fed the powdered fortified preterm human milk had higher bone mineralization than those fed the liquid supplemented human milk.
The Light Response of ON Bipolar Neurons Requires Gα<sub>o</sub> (2000)

ON bipolar neurons in retina detect the glutamate released by rods and cones via metabotropic glutamate receptor 6 (mGluR6), whose cascade is unknown. The trimeric G-protein G o might mediate this cascade because it colocalizes with mGluR6. To test this, we studied the retina in mice negative for the α subunit of G o (Gα o −/−). Retinal layering, key cell types, synaptic structure, and mGluR6 expression were all normal, as was the a-wave of the electroretinogram, which represents the rod and cone photocurrents. However, the b-wave of the electroretinogram, both rod- and cone-driven components, was entirely missing. Because the b-wave represents the massed response of ON bipolar cells, its loss in the Gα o null mouse establishes that the light response of the ON bipolar cell requires G o . This represents the first function to be defined in vivo for the α subunit of the most abundant G-protein of the brain .
Indications for Marrow Transplantation (1984)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Studies Regarding The Mechanism of False Negative Urea Breath Tests With Proton Pump Inhibitors (2003)

PPI-induced negative UBT results were related to the anti-H. pylori effect of the PPI. Acidification of the stomach did not prevent false negative UBT results. Three days is likely the minimum delay from stopping PPI until one should perform a test for active infection. A delay of 14 days is preferred.
Plasma density measurement using a simple microwave technique (1988)

We describe a simple method of determining the plasma density unambiguously with the help of a microwave interferometer. The frequency of the Klystron source is modulated with the help of a staircase voltage pulse. The height of each staircase is adjusted in such a way that the corresponding phase shift is 90°. Signals proportional to the cosine and sine of the phase shift due to plasma are generated, and the plasma density is unambiguously measured. The advantages of the method are highlighted in the text.
Guided Music Synthesis with Variable Markov Oracle (2014)

In this work the problem of guided improvisation is approached and elaborated; then a new method, Variable Markov Oracle, for guided music synthesis is proposed as the first step to tackle the guided improvisation problem. Variable Markov Oracle is based on previous results from Audio Oracle, which is a fast indexing and recombination method of repeating sub-clips in an audio signal. The newly proposed Variable Markov Oracle is capable of identifying inherent datapoint clusters in an audio signal while tracking the sequential relations among clusters at the same time. With a target audio signal indexed by Variable Markov Oracle, a query-matching algorithm is devised to synthesize new music materials by recombination of the target audio matched to a query audio. This approach makes the query-matching algorithm a solution to the guided music synthesis problem. The query-matching algorithm is efficient and intelligent since it follows the inherent clusters discovered by Variable Markov Oracle, creating a query-by-content result which allows numerous applications in concatenative synthesis, machine improvisation and interactive music system. Examples of using Variable Markov Oracle to synthesize new musical materials based on given music signals in the style of Jazz are shown.
Third-order nonlinear optical properties of a vanadyl naphthalocyanine derivative (1993)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTThird-order nonlinear optical properties of a vanadyl naphthalocyanine derivativeHari Singh Nalwa, Atsushi Kakuta, and Akio MukohCite this: J. Phys. Chem. 1993, 97, 6, 1097–1100Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/j100108a001https://doi.org/10.1021/j100108a001research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Quandary Of Megan's Law: When The Child Sex Offender Is A Child, 37 J. Marshall L. Rev. 73 (2003) (2003)

Wind is a former law enforcement
Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies (2008)

Therapeutic monoclonal antibodies against the epidermal growth factor receptor (EGFR) have advanced the treatment of colon and head and neck cancer, and show great promise for the development of treatments for other solid cancers. Antibodies against EGFR have been shown to act via inhibition of receptor signaling and induction of antibody-dependent cellular cytoxicity. However, complement-dependent cytotoxicity, which is considered one of the most powerful cell killing mechanisms of antibodies, seems inactive for such antibodies. Here, we show a remarkable synergy for EGFR antibodies. Combinations of antibodies against EGFR were identified, which resulted in potent complement activation via the classic pathway and effective lysis of tumor cells. Studies on a large panel of antibodies indicated that the observed synergy is a general mechanism, which can be activated by combining human IgG1 antibodies recognizing different, nonoverlapping epitopes. Our findings show an unexpected quality of therapeutic EGFR antibodies, which may be exploited to develop novel and more effective treatments for solid cancers.
Comparison of the coexpression of cd38, cd33 and hla‐dr antigens on cd34 <sup>+</sup> purified cells from human cord blood and bone marrow (1995)

Human umbilical cord blood (UCB) cells are currently considered as a potential source of stem cells for transplantation. However, it remains unclear whether a single collection of UCB contains enough progenitors to allow a successful engraftment in adult patients. We were interested in the comparison of the frequency of primitive progenitors in UCB and in human bone marrow (BM). UCB and BM CD34+ cells were purified and compared for their coexpression of CD38, CD33 and HLA-DR. UCB and BM mononuclear fractions were enriched in CD34+ cells using the CEPRATE LC system (CellPro, Bothell, WA). Double-labeling analysis with a flow cytometer showed that 67.9 +/- 7.2% of UCB CD34+ cells are CD38-, while in BM only 10.9 +/- 4.9% of CD34+ are CD38- (p < 0.001). Moreover, our study indicated that a significantly higher percentage of UCB CD34+ is CD33- (97.1 +/- 1.2%) compared to BM (61.8 +/- 8.6%) (p = 0.013). The coexpression of CD34 with HLA-DR was not significantly different in UCB and in BM (respectively, 86.3 +/- 2.7% and 92.7 +/- 5.1%). On the other hand, in vitro assays showed that the number of multipotent (colony-forming units granulocyte-erythroid-macrophage-megakaryocyte [CFU-GEMM]), myeloid (colony-forming units granulocyte-macrophage [CFU-GM]) and erythroid (burst-forming units-erythroid [BFU-E]) progenitors is lower in the CD34+ population from UCB than from BM. In conclusion, in UCB, we have found a significantly higher percentage of CD34+ cells which lacked the expression of CD38 and CD33 antigens suggesting that UCB contains higher proportions of immature progenitor cells (CD34+CD38- and CD34+CD33-) than BM. It seems thus likely that fewer UCB CD34+ cells than BM CD34+ cells would be required for sustained engraftment following transplantation.
Inorganic Nanoprobes for Biological Sensing and Imaging (2008)

This groundbreaking resource offers you an up-to-date account of the pioneering activity pushing new boundaries in the emerging area of inorganic nanoprobes and their use in biology and medicine. Written and edited by leading experts in the field, this unique book places particular emphasis nanoprobes made of luminescent semiconductor nanocrystals (quantum dots or QDs) and magnetic nanoparticles (MNPs). You find an insightful discussion on the synthesis, characterization, and analysis of the unique properties of luminescent QDs and MNPs. Moreover, this in-depth volume covers assay design and detection, including discussions on the design and implementation of in vitro assay studies using both fluorescence emission and magnetic contast. You also learn how to use luminescent QDs to design fluorescence resonance energy transfer (FRET) investigations. Further, this cutting-edge book looks at the use of QDs and magnetic nanoparticles for live cell imaging and intracellular sensing. You gain a thorough understanding of membrane labeling, means of delivery QD and MNP Cargos inside live cells, the use of infrared emitting QDs for tissue imaging, deep tissue imaging with MNPs based on magnetic contrast, and toxicity issues associated with the use of inorganic probes to live cells and tissue.
Vcode: a data-parallel intermediate language (2002)

A description is given of Vcode, a data-parallel intermediate language. Vcode is designed to allow easy porting of data-parallel languages to a wide class of parallel machines, and for experimenting with compiling such languages. The design goal was to define a simple language whose primitives can be implemented efficiently but that is still powerful enough to express the features of existing data-parallel languages. Vcode contains about 50 instructions, most of which manipulate arbitrarily long vectors of atomic values, and includes a set of segmented instructions that are crucial for implementing data-parallel languages that permit nested parallelism. The design decisions are discussed, and it is shown how three data-parallel languages-C*, Fortran 8*, and Paralation Lisp-can be mapped onto Vcode. The issues encountered in implementing Vcode on different kinds of parallel machines, as well as specific techniques for implementing it on the Connection Machine, are examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins (1993)

The enhancer for the immunoglobulin mu heavy chain gene (IgH) activates a heterologous gene at the pre-B cell stage of B lymphocyte differentiation. A lymphoid-specific element, microB, is necessary for enhancer function in pre-B cells. A microB binding protein is encoded by the PU.1/Spi-1 proto-oncogene. Another sequence element, microA, was identified in the mu enhancer that binds the product of the ets-1 proto-oncogene. The microA motif was required for microB-dependent enhancer activity, which suggests that a minimal B cell-specific enhancer is composed of both the PU.1 and Ets-1 binding sites. Co-expression of both PU.1 and Ets-1 in nonlymphoid cells trans-activated reporter plasmids that contained the minimal mu enhancer. These results implicate two members of the Ets family in the activation of IgH gene expression.
Robust architectural support for transactional memory in the power architecture (2013)

On the twentieth anniversary of the original publication [10], following ten years of intense activity in the research literature, hardware support for transactional memory (TM) has finally become a commercial reality, with HTM-enabled chips currently or soon-to-be available from many hardware vendors. In this paper we describe architectural support for TM added to a future version of the Power ISA™. Two imperatives drove the development: the desire to complement our weakly-consistent memory model with a more friendly interface to simplify the development and porting of multithreaded applications, and the need for robustness beyond that of some early implementations. In the process of commercializing the feature, we had to resolve some previously unexplored interactions between TM and existing features of the ISA, for example translation shootdown, interrupt handling, atomic read-modify-write primitives, and our weakly consistent memory model. We describe these interactions, the overall architecture, and discuss the motivation and rationale for our choices of architectural semantics, beyond what is typically found in reference manuals.
Fast marching tree: A fast marching sampling-based method for optimal motion planning in many dimensions (2015)

In this paper we present a novel probabilistic sampling-based motion planning algorithm called the Fast Marching Tree algorithm (FMT*). The algorithm is specifically aimed at solving complex motion planning problems in high-dimensional configuration spaces. This algorithm is proven to be asymptotically optimal and is shown to converge to an optimal solution faster than its state-of-the-art counterparts, chiefly PRM* and RRT*. The FMT* algorithm performs a "lazy" dynamic programming recursion on a predetermined number of probabilistically-drawn samples to grow a tree of paths, which moves steadily outward in cost-to-arrive space. As such, this algorithm combines features of both single-query algorithms (chiefly RRT) and multiple-query algorithms (chiefly PRM), and is reminiscent of the Fast Marching Method for the solution of Eikonal equations. As a departure from previous analysis approaches that are based on the notion of almost sure convergence, the FMT* algorithm is analyzed under the notion of convergence in probability: the extra mathematical flexibility of this approach allows for convergence rate bounds-the first in the field of optimal sampling-based motion planning. Specifically, for a certain selection of tuning parameters and configuration spaces, we obtain a convergence rate bound of order <i>O</i>(<i>n</i><sup>-1/<i>d</i>+ρ</sup>), where <i>n</i> is the number of sampled points, <i>d</i> is the dimension of the configuration space, and ρ is an arbitrarily small constant. We go on to demonstrate asymptotic optimality for a number of variations on FMT*, namely when the configuration space is sampled non-uniformly, when the cost is not arc length, and when connections are made based on the number of nearest neighbors instead of a fixed connection radius. Numerical experiments over a range of dimensions and obstacle configurations confirm our the-oretical and heuristic arguments by showing that FMT*, for a given execution time, returns substantially better solutions than either PRM* or RRT*, especially in high-dimensional configuration spaces and in scenarios where collision-checking is expensive.
Microstructure and origin of dislocation etch pits in GaN epilayers grown by metal organic chemical vapor deposition (2008)

Morphology and microstructure of dislocation etch pits in GaN epilayers etched by molten KOH have been investigated by atomic force microscopy, scanning electron microscopy, and transmission electron microscopy (TEM). Three types of etch pits (α, β, and γ) are observed. The α type etch pit shows an inversed trapezoidal shape, the β one has a triangular shape, and the γ type one has a combination of triangular and trapezoidal shapes. TEM observation shows that α, β, and γ types etch pits originate from screw, edge, and mixed-type threading dislocations (TDs), respectively. For the screw-type TD, it is easily etched along the steps that the dislocation terminates, and consequently, a small Ga-polar plane is formed to prevent further vertical etching. For the edge-type TD, it is easily etched along the dislocation line. Since the mixed-type TDs have both screw and edge components, the γ type etch pit has a combination of α and β type shapes. It is also found that the chemical stabilization of Ga-polar surface plays an important role in the formation of various types of dislocation etch pits.
Models of Ontogenetic Development for Autonomous Adaptive Systems (2001)

Biological organisms display an amazing ability during their ontogenetic development to adaptively develop solutions to the various problems of survival that their environments present to them. Dynamical and embodied models of cognition (Clark, 1997; Edelman &amp;amp; Tononi, 2000; Franklin, 1995; Freeman, 1999a, 1999b; Freeman &amp;amp; Kozma, 2000; Freeman, Kozma, &amp;amp; Werbos, 2000; Hendriks-Jansen, 1996; Kelso, 1995; Kozma &amp;amp; Freeman, 2001; Port &amp;amp; van Gelder, 1995; Skarda &amp;amp; Freeman, 1987; Thelen &amp;amp; Smith, 1994) are beginning to offer new insights into how the numerous, heterogeneous elements of neural structures may self-organize during the development of the organism in order to effectively form adaptive categories and increasingly sophisticated skills, strategies and goals. In this paper we present models of ontogenetic development built on neurologically inspired, bottom-up, dynamic approaches to embodied category formation such as those done by Freeman (1975, 1999b), Freeman and Kozma (2000), Kozma and Freeman (2001), Verschure (1998) and Edelman (1987, 1989). We believe that building on such mechanisms from an embodied dynamical perspective will produce autonomous agents that display greatly increased flexibility in their behavior. Such models will represent a better understanding of how the brains of biological organisms not only form perceptual categories of their environments during development, but also develop effective patterns of behavior through the dynamic self-organization of neurological patterns of activity.
Fibre-optic temperature sensor with wide temperature range characteristics (1987)

In the paper a fibre-optic sensor which can be used to measure temperature continuously over the range 300–1100 K is described and its characteristic is reported. The measurement of the ‘decay time’ of fluorescence of Nd-doped glass and garnet is used as the means of determining temperature with a solid-state optoelectronic sensor system.