gebhart/patrepeval huggingface dataset:
Influence of fatty acid composition on the tribological performance of two vegetable‐based lubricants (2007)

Abstract In light of diminishing natural resources, global climatic change and increased environmental sensitivity, renewable‐based lubricants are being considered potential alternatives to petroleum‐based lubricants. Understanding the tribological performance of vegetable‐based lubricants in relation to their chemical composition is essential for their industrial implementation. This study focuses on the friction and abrasion rate characteristics of soybean and sunflower oils in comparison to a base mineral oil under sliding wear at ambient conditions for various applied loads. It was found that the abrasion rate and friction were the least severe for the soybean, followed by the sunflower oil. The observed trends were attributed to differences in their fatty acid compositions, in particular, a lower percentage of linoleic and oleic acids within the soybean oil. Copyright © 2007 John Wiley &amp; Sons, Ltd.
Virtual network transport protocols for Myrinet (1998)

Bringing direct and protected network multiprogramming into mainstream cluster computing requires innovations in three key areas: application programming interfaces, network virtualization systems, and lightweight communication protocols for high-speed interconnects. The AM-II API extends traditional active messages with support for client-server computing and facilitates the construction of parallel clients and distributed servers. Our virtual network segment driver enables a large number of arbitrary sequential and parallel applications to access network interface resources directly in a concurrent but fully protected manner. The NIC-to-NIC communication protocols provide reliable and at-most-once message delivery between communication endpoints. The NIC-to-NIC protocols perform well as the number of endpoints and the number of hosts in the cluster are scaled. The flexibility afforded by the underlying protocols enables a diverse set of timely research efforts. Other Berkeley researchers are actively using this system to investigate implicit techniques for the coscheduling of communicating processes, an essential part of high-performance communications in multiprogrammed clusters of uni- and multiprocessor servers. Other researchers are extending the active message protocols described here for clusters of symmetric multiprocessors, using so-called multiprotocol techniques and multiple network interfaces per machine.
Matrix‐assisted laser desorption/ionization‐ quadrupole ion trap‐time of flight mass spectrometry sequencing resolves structures of unidentified peptides obtained by in‐gel tryptic digestion of haptoglobin derivatives from human plasma proteomes (2003)

Two-dimensional gel electrophoresis-separated and excised haptoglobin alpha2-chain protein spots were subjected to in-gel digestion with trypsin. Previously unassigned peptide ion signals observed in mass spectrometric fingerprinting experiments were sequenced using the matrix-assisted laser desorption/ionization-quadrupole ion trap-time of flight (MALDI-QIT-TOF) mass spectrometer and showed that the haptoglobin alpha-chain derivative under study was cleaved by trypsin unspecifically. Abundant cleavages occurred C-terminal to histidine residues at H23, H28, and H87. In addition, mild acidic hydrolysis leading to cleavage after aspartic acid residues at D13 was observed. The uninterpreted tandem mass spectrometry (MS/MS) spectrum of the peptide with ion signal at 2620.19 was submitted to database search and yielded the identification of the corresponding peptide sequence comprising amino acids (aa) aa65-87 from the haptoglobin alpha-chain protein. Also, the presence of a mixture of two tryptic peptides (mass to charge ratio m/z 1708.8; aa40-54, and aa99-113, respectively), that is caused by a tiny sequence variation between the two repeats in the haptoglobin alpha2-chain protein was resolved by MS/MS fragmentation using the MALDI-QIT-TOF mass spectrometer instrument. Advantageous features such as (i) easy parent ion creation, (ii) minimal sample consumption, and (iii) real collision induced dissociation conditions, were combined successfully to determine the amino acid sequences of the previously unassigned peptides. Hence, the novel mass spectrometric sequencing method applied here has proven effective for identification of distinct molecular protein structures.
Laser in situ Keratomileusis Flap Complications and Management (2000)

LASDX is a technically difficult surgical procedure with unique complications. Excellent flap management both intraoperatively and postoperatively is essential to maximize visual outcome. Some flap complications are easily managed and others require immediate expert surgical intervention to preserve good visual outcomes. [J Refract Surg 2000;16(suppl):S223-S225].
Estimating Item Parameters and Latent Ability when Responses are Scored in Two or More Nominal Categories (1972)

A multivariate logistic latent trait model for items scored in two or more nominal categories is proposed. Statistical methods based on the model provide 1) estimation of two item parameters for each response alternative of each multiple choice item and 2) recovery of information from “wrong” responses when estimating latent ability. An application to a large sample of data for twenty vocabulary items shows excellent fit of the model according to a chi-square criterion. Item and test information curves are compared for estimation of ability assuming multiple category and dichotomous scoring of these items. Multiple scoring proves substantially more precise for subjects of less than median ability, and about equally precise for subjects above the median.
STUDY OF PENICILLIN ANTIBODIES BY FLUORESCENCE POLARIZATION AND IMMUNODIFFUSION (1965)

1. Antibodies prepared in the rabbit to penicilloyl-rabbit serum albumin or to penicilloyl-bovine serum albumin were demonstrated by immunodiffusion and absorption methods to be apparently directed exclusively against the penicilloyl moiety. The antibodies could precipitate heavily substituted penicilloyl polylysine, as well as each other, with "reactions of identity". All could mutually deplete detectable antibodies by cross-absorption. 2. Small haptens containing both fluorescein and the penicilloyl group were synthesized. They were also capable of completely absorbing the antipenicilloyl antibodies from rabbit antiserum, as evidenced by immunodiffusion tests. The haptens were used in fluorescence polarization tests with gamma globulin from normal and immunized rabbits, and from normal and allergic humans. The rabbit antipenicilloyl gamma globulins in concentrations as low as 5 to 10 microg of protein/ml could significantly increase the polarization of the haptens. Normal gamma globulin had no effect at the highest concentrations tested, 1200 microg/ml. In all tests, rabbit and human antibody reacted similarly. 3. Fluorescence polarization titration curves for both human and rabbit antipenicilloyl gamma globulins were analyzed by computer and the antibody concentrations, avidities, and heterogeneity constants were determined. For the human antibody, the latter two values were 3.0 x 10(7)M(-1) and 0.78, while for the rabbit, they were 8.7 x 10(6)M(-1) and 0.71. The data were employed to estimate the limit of sensitivity of fluorescence polarization for detecting antipenicilloyl antibodies. Under the conditions employed, this value was roughly 0.4 microg antibody/ml. 4. When the whole rabbit sera were tested for penicilloyl antibodies by fluorescence polarization, both normal (preimmune) and immune sera revealed striking and equivalent increases in polarization with the penicilloyl haptens. This non-specific binding was shown to be due at least in part to serum albumin. Indications were obtained that it might be significantly reduced by increasing the pH or the salt concentration of the medium, or by addition of certain anions.
Strategy for the sequence analysis of heparin (1995)

The versatile biological activities of proteoglycans are mainly mediated by their glycosaminoglycan (GAG) components. Unlike proteins and nucleic acids, no satisfactory method for sequencing GAGs has been developed. This paper describes a strategy to sequence the GAG chains of heparin. Heparin, prepared from animal tissue, and processed by proteinases and endoglucuronidases, is 90% GAG heparin and 10% peptidoglycan heparin (containing small remnants of core protein). Raw porcine mucosal heparin was labelled on the amino termini of these core protein remnants with a hydrophobic, fluorescent tag [N-4-(6-dimethylamino-2-benzofuranyl) phenyl (NDBP)-isothiocyanate]. Enrichment of the NDBP-heparin using phenyl-Sepharose chromatography, followed by treatment with a mixture of heparin lyase I and III, resulted in a single NDBP-linkage region tetrasaccharide, which was characterized as deltaUAp(1-->3)-beta-D-Galp(1-->3)-beta-D-Galp(1-->4)-beta-Xylp -(1-->O-Ser-NDBP (deltaUAp is 4-deoxy-alpha-L-threo-hex-4-enopyranosyl uronic acid). Several NDBP-octasaccharides were isolated when NDBP-heparin was treated with only heparin lyase I. The structure of one of these NDBP-octasaccharides, deltaUAp2S(1-->4)-alpha-D-GlcNpAc(1-->4)-alpha-L-IdoAp (1-->4)-alpha-D-GlcNpAc6S(1-->4)-beta-D-GlcAp(1-->3)-beta-D- Galp(1-->3)-beta-D-Galp(1-->4)-beta-Xylp-(1-->O-Ser NDBP (S is sulphate, Ac is acetate), was determined by 1H-NMR and enzymatic methods. Enriched NDBP-heparin was treated with lithium hydroxide to release heparin, and the GAG chain was then labelled at xylose with 7-amino-1,3-naphthalene disulphonic acid (AGA). The resulting AGA-Xyl-heparin was sequenced on gradient PAGE using heparin lyase I and heparin lyase III. A predominant sequence in heparin at the protein core attachment site was deduced to be -D-GlcNp2S6S(or 6OH)(1-->4)-alpha-L-IdoAp2S-(1-->4)-alpha-D-GlcNp2S6S (or60H) (1-->4)-alpha-L-IdoAp2S(1-->4)-alpha-D-GlcNp2S6S( or 6OH)(1-->4)-alpha-L-IdoAp2S(1-->4)-alpha-D-GlcNpAc (1- ->4)-alpha-L-IdoAp(1-->4)-alpha-D-GlcNpAc6S(1-->4)-beta-D-++ +GlcAp(1-->3)-beta-D-Galp(1-->3)-beta-D-Galp(1-->4)-beta-Xyl-AGA.
Zinc‐induced changes in ionic currents of clonal rat pancreatic β‐cells: activation of ATP‐sensitive K<sup>+</sup> channels (2000)

The effects of zinc (Zn2+) on excitability and ionic conductances were analysed on RINm5F insulinoma cells under whole-cell and outside-out patch-clamp recording conditions. We found that extracellular application of 10-20 microM Zn2+ induced a reversible abolition of Ca2+ action potential firing, which was accompanied by an hyperpolarisation of the resting membrane potential. Higher concentrations of Zn2+, in the tens to hundreds micromolar range, induced a reversible reduction of voltage-gated Ca2+ and, to a lesser extent, K+ currents. Low-voltage-activated Ca2+ currents were more sensitive to Zn2+ block than high voltage-activated Ca2+ currents. The Zn2+-induced hyperpolarisation arose from a dose-dependent increase in a voltage-independent K+ conductance that was pharmacologically identified as an ATP-sensitive K+ (KATP) conductance. The effect was rapid in onset, readily reversible, voltage independent, and related to intracellular ATP concentration. In the presence of 1 mM intracellular ATP, half-maximal activation of KATP channels was obtained with extracellular application of 1.7 microM Zn2+. Single channel analysis revealed that extracellular Zn2+ increased the KATP channel open-state probability with no change in the single channel conductance. Our data support the hypothesis that Zn2+ binding to KATP protein subunits results in an activation of the channels, therefore regulating the resting membrane potential and decreasing the excitability of RINm5F cells. Taken together, our results suggest that Zn2+ can influence insulin secretion in pancreatic beta-cells through a negative feedback loop, involving both KATP and voltage-gated conductances.
The function and machanism of Ca~(2+) on cut flowers^ longevity of Rosa chinensis (2001)

It was found that Ca~(2+) could enable cut flowers of Rosa chinensis to promot water absorption, reduce water loss, decrease respiratory intensity, increase sugar absorption, postpone protein resolution, resistaging by the way of determining cut flowers storage time and physiological-biochemical indexes in different solutions of cut flowers, hence a long storage time of Rosa chinensis was obtained.
Biosynthesis of human cystathionine beta-synthase in cultured fibroblasts. (1984)

A single specific radiolabeled polypeptide with an apparent Mr = 63,000 was recovered when cystathionine beta-synthase (EC 4.2.1.22) was precipitated from extracts of radiolabeled cultured human fibroblasts with an antiserum raised against pure human liver synthase, and the immunocomplexes were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Partial proteolysis of this fibroblast subunit and of the subunit of pure human liver synthase (Mr = 48,000) produced similar peptide patterns. Pulse-chase experiments, however, did not provide any evidence for post-translational modification of the fibroblast synthase subunit into a smaller "hepatic" form. Immunoprecipitation of polypeptides synthesized in vitro from human fibroblast mRNA revealed a polypeptide with the same mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis as the synthase subunit found in whole cell extracts. We conclude that the Mr = 63,000 subunit is the primary translational product of the gene for cystathionine beta-synthase in human fibroblasts.
DIALKYL THIAZOLIDIONES (1938)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTDIALKYL THIAZOLIDIONESWILBUR J. DORAN and H. A. SHONLECite this: J. Org. Chem. 1938, 03, 3, 193–197Publication Date (Print):July 1, 1938Publication History Published online1 May 2002Published inissue 1 July 1938https://pubs.acs.org/doi/10.1021/jo01220a001https://doi.org/10.1021/jo01220a001research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Localization of the dominant flocculation genes <i>FLO5</i> and <i>FLO8</i> of <i>Saccharomyces cerevisiae</i> (1995)

In the yeast Saccharomyces cerevisiae three dominant flocculation genes, FLO1, FLO5 and FLO8 have been described. Until now only the FLO1 gene, which is located at chromosome I, has been cloned and sequenced. FLO5 and FLO8 were previously localized at chromosomes I and VIII respectively (Vezinhet, F., Blondin, B. and Barre, P. (1991). Mapping of the FLO5 gene of Saccharomyces cerevisiae by transfer of a chromosome during cytoduction. Biotechnol. Lett. 13, 47-52; Yamashita, I. and Fukui, S. (1983). Mating signals control expression of both starch fermentation genes and a novel flocculation gene FLO8 in the yeast Saccharomyces. Agric. Biol. Chem. 47, 2889-2896). This was not in agreement with our results. Here, we report the location of FLO5 and FLO8 on chromosomes VIII and I respectively. By induced chromosome loss and genetic mapping, the FLO5 gene was localized at the right end of chromosome VIII approximately 34 cM centromere distal of PET3. This is part of the region that is present both at chromosome I and chromosome VIII. The location of FLO5 in this area of chromosome VIII made it necessary to re-evaluate the localization of FLO8, which was previously thought to occur in this region. Both genetic and physical mapping showed that FLO8 is allelic to FLO1. Hence, there are only two known dominant flocculation genes, FLO1 and FLO5. Analysis of the nucleotide sequence of chromosome VIII of a non-flocculent strain revealed an open reading frame encoding a putative protein that is approximately 96% identical to the Flo1 protein. This suggests that both dominant flocculation genes encode similar, cell wall-associated, proteins with the same function in the flocculation mechanism.
An immunologic homunculus for type 1 diabetes (2006)

Autoimmune diseases such as the diabetes that develops in NOD mice depend on immunologic recognition of specific autoantigens, but recognition can result in a pathogenic or protective T cell response. A study by Du et al. in this issue of the JCI demonstrates that TGF-beta signaling by T cells recognizing the insulin peptide B:9-23 is essential for such protection and that this inhibitory cytokine functions in both a paracrine and an autocrine manner (see the related article beginning on page 1360). We propose that the insulin peptide B:9-23 and a conserved TCR motif form an "immunologic homunculus" underlying the relatively common targeting of insulin by T cells that, as demonstrated by the study of Du and coworkers, results in a protective T cell response, or diabetes, as shown by other investigators, for related T cell receptors.
QUIC: A Fast-Running High-Resolution 3D Building-Aware Urban Transport and Dispersion Modeling System (2014)

Transport and dispersion of airborne contaminants in urban environments is extremely complicated. Buildings alter the flow fields and deflect the wind, causing updrafts and downdrafts, channeling between buildings, areas of calm winds adjacent to strong winds, and horizontally and vertically rotating-eddies between buildings, at street corners, and other places within the urban canopy. High concentrations of fine particulate matter or carbon monoxide over short time periods can result from vehicle emissions that become trapped between tall buildings in urban areas. Toxic industrial chemicals are often transported via railcar and trucks near or through cities and stored among buildings and other structures at industrial and manufacturing sites that are sometimes found in or near inhabited locations. In addition to accidental releases, there is also concern of pre-meditated chemical, biological, and radiological attacks in cities.
Effect of sodium cloprostenol and flunixin meglumine on luteolysis and the timing of birth in bitches (1999)

At birth, the physiological role of prostaglandins in bitches is unclear. Bitches were treated before parturition with either saline, the prostaglandin analogue, sodium cloprostenol, or the prostaglandin synthetase inhibitor, flunixin meglumine. The animals were examined regularly to determine the onset of parturition and a series of blood samples were taken to define the hormonal profiles before, during and after birth. Animals treated with cloprostenol whelped earlier than did controls. In addition, the prostaglandin F2 alpha metabolite surge and decrease in plasma progesterone concentration and rectal temperature were earlier than in controls. Flunixin meglumine disrupted the normal 13,14-dihydro-15-keto prostaglandin F2 alpha profile but did not abolish prostaglandin synthesis completely or delay the onset of labour in treated animals. This study confirms that prostaglandins induce luteolysis and the onset of labour in the bitch. However, the partial inhibition of prostaglandin synthesis does not prevent parturition.
Efficient Optimization for Autonomous Robotic Manipulation of Natural Objects (2014)

Manipulating natural objects of irregular shapes, such as rocks, is an essential capability of robots operating in outdoor environments. Physics-based simulators are commonly used to plan stable grasps for man-made objects. However, planning is an expensive process that is based on simulating hand and object trajectories in different configurations, and evaluating the outcome of each trajectory. This problem is particularly concerning when the objects are irregular or cluttered, because the space of feasible grasps is significantly smaller, and more configurations need to be evaluated before finding a good one. In this paper, we first present a learning technique for fast detection of an initial set of potentially stable grasps in a cluttered scene. The best detected grasps are further optimized by fine-tuning the configuration of the hand in simulation. To reduce the computational burden of this last operation, we model the outcomes of the grasps as a Gaussian Process, and use an entropy-search method in order to focus the optimization on regions where the best grasp is most likely to be. This approach is tested on the task of clearing piles of real, unknown, rock debris with an autonomous robot. Empirical results show a clear advantage of the proposed approach when the time window for decision is short.
Memapsin 2 (β-secretase) as a therapeutic target (2002)

As beta-secretase, memapsin 2 cleaves amyloid-beta precursor protein, which leads ultimately to the onset of Alzheimer's disease. As such, memapsin 2 is an excellent target of inhibitor drugs for the treatment of this disease. Here we describe the tools for memapsin 2 inhibitor design that have been developed and results from the structure-based inhibitor design. Strategy for the design of memapsin 2 inhibitors with pharmaceutical potential is also discussed.
A set of multi-touch graph interaction techniques (2010)

Interactive node-link diagrams are useful for describing and exploring data relationships in many domains such as network analysis and transportation planning. We describe a multi-touch interaction technique set (IT set) that focuses on edge interactions for node-link diagrams. The set includes five techniques (TouchPlucking, TouchPinning, TouchStrumming, TouchBundling and PushLens) and provides the flexibility to combine them in either sequential or simultaneous actions in order to address edge congestion.
Comparative Study of CNN and RNN for Natural Language Processing (2017)

Deep neural networks (DNN) have revolutionized the field of natural language processing (NLP). Convolutional neural network (CNN) and recurrent neural network (RNN), the two main types of DNN architectures, are widely explored to handle various NLP tasks. CNN is supposed to be good at extracting position-invariant features and RNN at modeling units in sequence. The state of the art on many NLP tasks often switches due to the battle between CNNs and RNNs. This work is the first systematic comparison of CNN and RNN on a wide range of representative NLP tasks, aiming to give basic guidance for DNN selection.
Effectiveness of Pneumococcal Polysaccharide Vaccine in Older Adults (2003)

These findings support the effectiveness of the pneumococcal polysaccharide vaccine for the prevention of bacteremia, but they suggest that alternative strategies are needed to prevent nonbacteremic pneumonia, which is a more common manifestation of pneumococcal infection in elderly persons.
Quantitative computed tomography for the prediction of pulmonary function after lung cancer surgery: a simple method using simulation software☆ (2008)

Quantitative CT yielded accurate prediction of functional reserve after lung cancer surgery and helped to identify patients whose functional reserves are likely to be underestimated. Hence, this modality should be utilized for patients with marginal pulmonary function.