gebhart/patrepeval huggingface dataset:
Genesis of Archean Peridotitic Magmas and Constraints on Archean Geothermal Gradients and Tectonics (1975)

Research Article| January 01, 1975 Genesis of Archean Peridotitic Magmas and Constraints on Archean Geothermal Gradients and Tectonics D. H. Green D. H. Green 1Research School of Earth Sciences, Australian National University, Canberra, A.C.T., Australia Search for other works by this author on: GSW Google Scholar Author and Article Information D. H. Green 1Research School of Earth Sciences, Australian National University, Canberra, A.C.T., Australia Publisher: Geological Society of America First Online: 02 Jun 2017 Online ISSN: 1943-2682 Print ISSN: 0091-7613 Geological Society of America Geology (1975) 3 (1): 15–18. https://doi.org/10.1130/0091-7613(1975)3<15:GOAPMA>2.0.CO;2 Article history First Online: 02 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation D. H. Green; Genesis of Archean Peridotitic Magmas and Constraints on Archean Geothermal Gradients and Tectonics. Geology 1975;; 3 (1): 15–18. doi: https://doi.org/10.1130/0091-7613(1975)3<15:GOAPMA>2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract The experimentally determined extrusion temperature (1650° ± 20°C) for Archean peridotitic komatiite magma implies diapirism of upper mantle peridotite from a depth of at least 200 km. Models of magma genesis are developed in which selective removal of garnet during ascent produces CaO/Al2O3 > 1 and heavy rare-earth element depletion in the resultant peridotitic or mafic extrusions. Magma genesis can be interpreted with a model of the Archean geotherm, lithosphere, and plate tectonics processes resembling the modern Earth, but this does not account for the distinctive preservation and character of Archean greenstone belts. A preferred model of a steeper Archean geotherm, thin lithosphere (≃50 km), and asthenosphere with approximately 5 percent melting does not allow eclogitization and subduction of basaltic oceanic crust, but it postulates scraping off of such crust against and between primitive sialic nucleii. This model may account for the distinctive characteristics of the Archean greenstone and “granite” terranes. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Influence of the seed polymer on the chromatographic properties of size monodisperse polymeric separation media prepared by a multi‐step swelling and polymerization method (1993)

Abstract Monodisperse polymer particle‐based separation media were prepared by a multi‐step swelling and polymerization method with two pairs of monomers and two porogenic solvents. Their chromatographic properties were compared to those of beads prepared by a corresponding suspension polymerization method without the use of seed polymer to ascertain the influence of the seed polymer on their porous structures. A large change in porous structure was observed when the swollen particle consisting of monomers and porogenic solvents contained at least one good solvent for the polystyrene seed polymer, allowing it to remain in the polymerizing medium. In contrast, when the polystyrene seed particle was excluded from the swollen oil droplets, due to its poor solubility in the monomers and the porogenic solvents, there was no difference in the chromatographic properties such as pore volume, pore size, pore size distribution, or retention selectivity between the multi‐step swelling and polymerization method and the suspension polymerization method. Since the only difference between the multi‐step swelling and polymerization method and the suspension method is the use of the seed polymer, it appears that a very small amount (&lt; 1% v/v) of seed polymers in the enlarged swollen droplets plays an important role as a porogen and affects the porous structure as well as the chromatographic properties of the monodisperse polymer particle‐based separation media. © 1993 John Wiley &amp; Sons, Inc.
Michelle Bachelet's Government: The Paradoxes of a Chilean President (2012)

The purpose of this article is to explain the contradictions in Michelle Bachelet's presidency by focusing on the paradoxical nature of presidential power, the limits on the executive in the Chilean constitution, and how those limits affected President Bachelet's government. At the outset of her presidency, she faced the problem of wanting to promote inclusive policies while simultaneously experiencing political pressure to maintain elite consensus. Due to institutional and political constraints, Bachelet's rhetoric of inclusion could not be realized, and she eventually decided to opt for the more traditional elite consensus approach. In our view, the emphasis on achieving elite consensus produced contradictory results. It sustained Bachelet's personal image as a national leader, but limited her ability to get effective legislation passed. Indeed, the Concertación itself was blamed for inaction rather than the president as an individual.
Insulin-induced Activation of NADPH-dependent H2O2 Generation in Human Adipocyte Plasma Membranes Is Mediated by Gαi2 (1997)

Human fat cells possess a multireceptor-linked H2O2-generating system that is activated by insulin. Previous studies revealed that manganese was the sole cofactor required for a hormonal regulation of NADPH-dependent H2O2 generation in vitro. In this report it is shown that the synergistic activation of NADPH-dependent H2O2 generation by Mn2+ and insulin was blocked by GDPbetaS (guanosine 5'-O-(2-thiodiphosphate)), pertussis toxin and COOH-terminal anti-Galphai1-2 or the corresponding peptide. Consistently, manganese could be replaced by micromolar concentrations of GTPgammaS (guanosine 5'-O-(3-thiotriphosphate)), which increased NADPH-dependent H2O2 generation by 20-40%. Insulin shifted the dose response curve for GTPgammaS to the left (>10-fold) and increased the maximal response. In the presence of 10 microM GTPgammaS, the hormone was active at picomolar concentrations, indicating that insulin acted via its cognate receptor. The insulin receptor and Gi were co-adsorbed on anti-Galphai and anti-insulin receptor beta-subunit (anti-IRbeta) affinity columns. Partially purified insulin receptor preparations contained Galphas, Galphai2, and Gbetagamma (but no Galphai1 or Galphai3). The functional nature of the insulin receptor-Gi2 complex was made evident by insulin's ability to modulate labeling of Gi by bacterial toxins. Insulin action was mimicked by activated Galphai, but not by Galphao or Gbetagamma, indicating that insulin's signal was transduced via Galphai2. Thus, NADPH oxidase is the first example of an effector system that is coupled to the insulin receptor via a heterotrimeric G protein.
An efficient approach to solving the agent training problem for a sustainable group (2013)

Adaptive Collaboration (AC) aims at building a sustainable group that can work well even though the environment and the state of the group change. Initial role assignment or agent training is an important task for a group to be sustainable. There are many variations and different requirements in the process of role assignment. In this paper, an efficient approach is proposed to solve the problem of agent training for a sustained group. This approach is based on the IBM ILOG CPLEX Optimization Package. The performance is verified by experiments with randomly created groups. The major contribution of this paper is to clarify the problem of initial group role assignment for a sustainable group and propose an efficient and practical solution.
Factors affecting the performance of conventional seepage meters (2003)

The simplicity of a pan‐and‐bag seepage meter makes it an attractive tool for a variety of hydrologic investigations, but the performance of this device is far from simple. Laboratory experiments show that the hydraulic head required to fill collection bags can range from 0.5 mm to several millimeters at flow rates typical of seepage meters, and this additional head will divert water away from the pan. A theoretical analysis gives a semianalytical expression for the flux captured by a seepage meter using a collection bag. The analysis shows that bag conductance, radius of the pan, and hydraulic conductivity of the stream bed can be combined to give a dimensionless term that characterizes seepage meter performance. Field experiments in a sandy streambed show that conventional seepage meters can resolve spatial differences in ground water flux but only when using a highly conductive collection system that is isolated from the current.
Interpreting the Data: Parallel Analysis with Sawzall (2005)

Very large data sets often have a flat but regular structure and span multiple disks and machines. Examples include telephone call records, network logs, and web document repositories. These large data sets are not amenable to study using traditional database techniques, if only because they can be too large to fit in a single relational database. On the other hand, many of the analyses done on them can be expressed using simple, easily distributed computations: filtering, aggregation, extraction of statistics, and so on. We present a system for automating such analyses. A filtering phase, in which a query is expressed using a new procedural programming language, emits data to an aggregation phase. Both phases are distributed over hundreds or even thousands of computers. The results are then collated and saved to a file. The design – including the separation into two phases, the form of the programming language, and the properties of the aggregators – exploits the parallelism inherent in having data and computation distributed across many machines.
&lt;title&gt;Process-optimizing adaptive optics for the beam delivery of high-power CO2 lasers&lt;/title&gt; (1993)

With this paper a newly developed optical device for an active beam guidance and forming in CO<SUB>2</SUB> laser systems is presented. The availability of this additional tuning element in processing will solve current problems in beam delivery as well as offer new laser processing options. By integrating this optic in the beam delivery: (1) the process conditions can be improved, (2) the process influencing effects in beam propagation or delivery can be compensated, (3) the workpieces with complex structures and difficult accessibility can be processed in conformance with high quality standards, and (4) new laser processing options are possible.
Angiogenesis: A Target in Solid Tumors, Also in Leukemia? (2011)

Abstract Targeting angiogenesis has become an established therapeutic approach to fighting solid tumor growth in cancer patients. Even though increased angiogenesis has long been recognized in various types of hematologic malignancies, the molecular basis underlying this angiogenic switch in leukemias remains poorly understood. The BM stroma is gaining increasing attention for its role in promoting leukemia growth and resistance against current treatments with tyrosine kinase inhibitors. This article provides a brief overview of the role of angiogenesis in leukemias, discusses recent insights into the role of placenta growth factor (PlGF), a VEGF family member, as a novel disease candidate in chronic myeloid leukemia (CML), and highlights the therapeutic potential of PlGF blockade for imatinib-resistant CML.
Treatment with Interferon Beta-1b Improves Quality of Life in Multiple Sclerosis (1999)

Patients with relapsing forms of MS treated with IFNB-1b have better QoL than patients who are not treated, especially those with an EDSS < 3.0.
In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway. (1996)

To study the role of apoC1 in lipoprotein metabolism, we have generated transgenic mice expressing the human APOC1 gene. On a sucrose-rich diet, male transgenic mice with high APOC1 expression in the liver showed elevated levels of serum cholesterol and triglyceride compared with control mice (5.7+/-0.7 and 3.3+/-2.1 vs. 2.7+/-0.1 and 0.4+/-0.1 mmol/liter, respectively). These elevated levels were mainly confined to the VLDL fraction. Female APOC1 transgenic mice showed less pronounced elevated serum lipid levels. In vivo VLDL turnover studies revealed that, in hyperlipidemic APOC1 transgenic mice, VLDL particles are cleared less efficiently from the circulation as compared with control mice. No differences were observed in the hepatic production and extrahepatic lipolysis of VLDL-triglyceride. Also, VLDL isolated from control and APOC1 transgenic mice were found to be equally good substrates for bovine lipoprotein lipase in vitro. These data indicate that the hyperlipidemia in APOC1 transgenic mice results primarily from impaired hepatic VLDL particle clearance, rather than a defect in the hydrolysis of VLDL-triglyceride. To investigate which hepatic receptor is involved in the apoC1-mediated inhibition of VLDL clearance, APOC1 transgenic mice were bred with an LDL receptor-deficient (LDLR(-/-)) background. In addition, control, LDLR(-/-), and LDLR(-/-)/APOC1 mice were transfected with adenovirus carrying the gene for the receptor-associated protein (Ad-RAP). Both serum cholesterol and triglyceride levels were strongly elevated in LDLR(-/-)/APOC1 mice compared with LDLR(-/-) mice (52+/-19 and 36+/-19 vs. 8.4+/-0.9 and 0.5+/-0.2 mmol/liter, respectively), indicating that apoC1 inhibits the alternative VLDL clearance pathway via the remnant receptor. Transfection of LDLR(-/-) mice with Ad-RAP strongly increased serum cholesterol and triglyceride levels, but to a lesser extent than those found in LDLR(-/-)/APOC1 mice (39+/-8 and 17+/-8 vs. 52+/-19 and 36+/-19 mmol/liter, respectively). However, in LDLR(-/-)/APOC1 mice the transfection with Ad-RAP did not further increase serum cholesterol and triglyceride levels (52+/-19 and 36+/-19 vs. 60+/-10 and 38+/-7 mmol/liter, respectively). From these studies we conclude that, in the absence of the LDLR, apoC1 inhibits the hepatic uptake of VLDL via a RAP-sensitive pathway.
Increased secretion of hyperimmune antibodies following lipopolysaccharide stimulation of CD40‐activated human B cells <i>in vitro</i> (2008)

Human B cells can be cultured ex vivo for a few weeks, following stimulation of the CD40 cell surface molecule in the presence of recombinant cytokines such as interleukin-4 (IL-4). However, attempts to produce polyclonal antigen-specific human antibodies by in vitro culture of human B cells obtained from immunized donors have not been successful. It has been shown in mice that lipopolysaccharide (LPS) is a potent mitogen for B cells and plays an important role in the generation of antigen-specific antibody responses. Although it has long been believed that LPS has no direct effect on human B cells, recent data indicating that IL-4-activated human B cells are induced to express Toll-like receptor-4, the main LPS receptor, prompted us to study the effects of LPS on the proliferation and antibody secretion of human B cells. Our results showed that LPS caused a reduction in the expansion of CD40-activated human B cells, accompanied by an increase in antigen-specific antibody secretion. This result suggested that some, but not all, B cells were able to differentiate into antibody-secreting cells in response to LPS. This increased differentiation could be explained by the observation that LPS-stimulated human B cells were induced to secrete higher amounts of IL-6, a pleiotropic cytokine well-known for its B-cell differentiation activity. In vivo, the effect of LPS on cytokine secretion by B cells may not only enhance B-cell differentiation but also help to sustain a local ongoing immune response to invading Gram-negative bacteria, until all pathogens have been cleared from the organism.
Mutational analysis of the feedback sites of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli (1997)

In Escherichia coli, aroF, aroG, and aroH encode 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase isozymes that are feedback inhibited by tyrosine, phenylalanine, and tryptophan, respectively. In vitro chemical mutagenesis of the cloned aroG gene was used to identify residues and regions of the polypeptide essential for phenylalanine feedback inhibition.
Transparent Solid‐State Lithiated Neutron Scintillators Based on Self‐Assembly of Polystyrene‐<i>block</i>‐poly(ethylene oxide) Copolymer Architectures (2004)

A new transparent neutron-scintillating material has been developed based on polystyrene-block-poly(ethylene oxide). The unique self-assembly structure of the block copolymer makes it possible to dope hydrophilic Li+ in the ethylene-oxide domain and hydrophobic organic fluors in the styrene domain (see Figure).
Exploring the issues in policy-based approaches for QoS support in 3G/sup +/ mobile networks (2005)

In this paper, we explore the issues in policy-based approaches for quality of service (QoS) support in beyond 3G (3G/sub +/) mobile networks. QoS support in mobile environments per-user and per-service is a formidable task. Third Generation Project Partnership (3GPP) puts emphasis on a uniform QoS policy management (definition, control, and enforcement) and common open policy service (COPS) is specified for policy signalling. We show that the policy-based QoS approach is a promising solution to address QoS issue in 4G (a.k.a. 3G/sub +/) networks. That is, end-to-end QoS policy approach enables finer-grained service and user differentiation, leading to better subscription-tiering management.
Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone (1997)

Recently, we developed a targeted cytotoxic analog AN-207 of luteinizing hormone-releasing hormone (LH-RH), consisting of an intensely potent derivative of doxorubicin, 2-pyrrolinodoxorubicin (AN-201) conjugated to carrier agonist [D-Lys6]LH-RH. In this study, we investigated the effects of cytotoxic analog AN-207, designed for targeted chemotherapy and radical AN-201 on pituitary function in rats. A selective damage to the pituitary gonadotroph cells was found at 1 week after a single i.v. injection of 150 nmol/kg AN-207, as evidenced by a 63% decrease in the LH-RH-stimulated release of LH in vitro. The release of growth hormone (GH) and thyrotropin (TSH), stimulated by GH-releasing hormone (GH-RH) and TSH-releasing hormone (TRH), respectively, was reduced by only 11-12%. In contrast, even a smaller dose of 75 nmol/kg of AN-201 nonselectively damaged pituitary function, reducing the stimulated release of LH, GH, and TSH by 57%, 74%, and 67%, respectively. Two weeks after administration, the LH-RH-stimulated LH release in vivo entirely normalized in the AN-207-treated rats, and only a 13% decrease in the LH response was found in the group given AN-201. GH and TSH responses to receptor-mediated stimuli with GH-RH and TRH were normal at 2 weeks in both treated groups. Neither cytotoxic compound caused changes in the concentration of pituitary LH, GH, or TSH, as determined by RIA at 1 week and 7 weeks after treatment. This study demonstrates that the cytotoxic LH-RH analog AN-207 exerts highly selective effects on the gonadotroph cells containing LH-RH receptors and is less toxic for other cells. Conversely, its cytotoxic radical AN-201 nonselectively damages the pituitary cells. The damaging effect of both cytotoxic compounds on pituitary functions is reversible. In view of its high selectivity and reduced toxicity, AN-207 could be a potential therapeutic agent for the treatment of tumors that possess receptors for LH-RH such as prostatic, mammary, ovarian, and endometrial cancers.
Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins (1995)

The development of Sendai virus-specific cytotoxic T-lymphocyte (CTL) effectors and precursors (CTLp) has been compared for mice that are homozygous (-/-) for a disruption of the H-2I-Ab class II major histocompatibility complex glycoprotein and for normal (+/+) controls. The generation of CD8+ CTLp was not diminished in the -/- mice, though they failed to make virus-specific immunoglobulin G class antibodies. While the cellularity of the regional lymph nodes was decreased, the inflammatory process assayed by bronchoalveolar lavage (BAL) of the pneumonic lung was not modified, and potent CTL effectors were present in BAL populations recovered from both groups at day 10 after infection. There was little effect on virus clearance. Production of interleukin-2 by both freshly isolated BAL inflammatory cells and cultured lymph node cells was greatly diminished, though the -/- mice still made substantial levels of gamma interferon. However, treating the mice with a single dose of a monoclonal antibody to this cytokine, at least some of which is made by CD8+ T cells, did not decrease CTLp frequencies. As found previously with CD4-depleted H-2b mice, the development of Sendai virus-specific CD8+ T-cell-mediated immunity is not compromised by the absence of a concurrent class II major histocompatibility complex-restricted response.
Coherent optical OFDM: has its time come? [Invited] (2008)

There has been growing interest in coherent optical orthogonal frequency-division multiplexing (CO-OFDM). We aim to present the case that the time for CO-OFDM has come, in terms of the demand from today's ever-advancing optical networks and the availability of its underlying technologies. We first lay out the signal processing aspect for CO-OFDM and then show a 2×2 multiple-input-multiple-output (MIMO) OFDM representation for the single-mode fiber optical channel. Through numerical simulation and experimental demonstration, we further present and discuss various MIMO-OFDM systems focusing on their polarization-mode dispersion resilience. Among those systems, the 2×1 MIMO-OFDM configuration incorporating polarization-time coding shows promise for optical access networks and broadcast networks. Finally, another class of the frequency-domain equalization techniques, namely, incoherent or coherent optical single-carrier frequency-domain equalization (CO-SCFDE) is discussed and experimentally demonstrated.