gebhart/patrepeval huggingface dataset:
Antitumor activity of new organometallic compounds in human ovarian cancer cell lines and comparison to platin derivatives. (1997)

Cisplatin, Carboplatin and new compounds such as Paclitaxel and Docetaxel are effective drugs in the treatment of ovarian cancer. Multidrug resistance however remains an issue in ovarian cancer. The search for new effective drugs will remain of the highest priority in the field of cancer research. The in vitro and in vivo growth inhibiting potencies of two new metallocene dichlorides, Titanocendichloride and Vanadocendichloride, were compared to Cisplatin and Carboplatin using 20 permanent human ovarian cancer cell lines. Under in vivo and in vitro conditions Cisplatin was more effective than Carboplatin. Under in vitro conditions a Vanadocendichloride concentration of as low as 1.5 x 10(-7) mol/l resulted in a 50% decrease in the cell proliferation. Titanocendichloride inhibited cellular growth only at concentrations of 10(-4) mol/l. In contrast, Titanocendichloride was more effective in inhibiting growth of xenotransplanted ovarian cancer cell lines in nude mice. The clinically supposed equipotentiality of Carboplatin should be handled cautiously. The new organometallic substances clearly exhibit antiproliferative properties in ovarian cancer cells and are considered for clinical phase I trials.
Recognizing Verbal Irony in Spontaneous Speech (2002)

We explored the differential impact of auditory information and written contextual information on the recognition of verbal irony in spontaneous speech. Based on relevance theory, we predicted that speakers would provide acoustic disambiguation cues when speaking in situations that lack other sources of information, such as a visual channel. We further predicted that listeners would use this information, in addition to context, when interpreting the utterances. People were presented with spontaneously produced ironic and nonironic utterances from radio talk shows in written or auditory form, with or without written contextual information. When the utterances were read without written contextual information, all utterances were rated as equally ironic. But when they were heard as opposed to read, or when they were presented in irony-biasing contexts, originally ironic utterances were rated as more sarcastic than originally nonironic utterances. This evidence suggests both acoustic and contextual information are used when inferring ironic intent in spontaneous speech, and validates previous manipulations of intonation in studies of irony understanding.
PerLa: A Language and Middleware Architecture for Data Management and Integration in Pervasive Information Systems (2011)

A declarative SQL-like language and a middleware infrastructure are presented for collecting data from different nodes of a pervasive system. Data management is performed by hiding the complexity due to the large underlying heterogeneity of devices, which can span from passive RFID(s) to ad hoc sensor boards to portable computers. An important feature of the presented middleware is to make the integration of new device types in the system easy through the use of device self-description. Two case studies are described for PerLa usage, and a survey is made for comparing our approach with other projects in the area.
Carbon-Hydrogen Groups in Hydrocarbons (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-Hydrogen Groups in HydrocarbonsR. R. Hibbard and A. P. CleavesCite this: Anal. Chem. 1949, 21, 4, 486–492Publication Date (Print):April 18, 1949Publication History Published online1 May 2002Published inissue 18 April 1949https://pubs.acs.org/doi/10.1021/ac60028a010https://doi.org/10.1021/ac60028a010research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Primate conservation in the new millennium: The role of scientists (2001)

For nearly three decades, the academic community has clearly recognized that many primate populations are severely threatened by human activities. In 1983, Wolfheim estimated that more than 50% of all primate species faced some form of threat. Over a decade later, the Primate Specialist Group of the Species Survival Commission of the World Conservation Union5 estimated that half of the world's 250 species of primates were of serious conservation concern. In a recent review of the current status of primate communities, Wright and Jernvall commented that it was an achievement for primate conservationists that we had not lost any species in the last millennium. It is ironic that the first documented extinction of a widely recognized primate taxon occurred just as we entered the new millennium. Based on surveys in Ghana and Cote d'lvoire, Oates and colleagues have failed to find any surviving populations of Miss Waldron's red colobus (Procolobus badius waldroni), a primate taxon endemic to this region and one that some authorities consider worthy of species status. Because 96 primate species are now considered to be critically endangered or endangered, much must be done in the near future to ensure that extinction curves do not lag behind tropical deforestation and high levels of commercial and subsistence hunting.
Blood Serotonin and Free Tryptophan Concentration in Autistic Children (1984)

In 37 autistic children and 67 normal control subjects, determinations of plasma free and total tryptophan and blood serotonin levels were made simultaneously in order to establish a relationship between these parameters and the clinical rating scales: Children's Psychiatric Rating Scale (CPRS-1), Werry-Weiss-Peters Activity Scale (WWPAS), and Developmental Quotient (DQ). The plasma free tryptophan level was significantly higher in autistic children than in normal control subjects. There tended to be a significant positive correlation between the plasma free tryptophan level and CPRS-1 or WWPAS score and a negative correlation between the plasma free tryptophan level and DQ. The blood serotonin level was significantly higher in autistic children than in normal control subjects. No correlation was established, however, between the blood serotonin level and CPRS-1, WWPAS score or DQ, and hence the clinical symptoms. Nor was there a correlation between blood serotonin and free tryptophan levels in these children. These results suggest that autistic children have some defect in tryptophan-serotonin metabolism in the brain, which is responsible for the clinical manifestations and behavioral abnormalities of infantile autism.
Bioanalysis in structured microfluidic systems (2006)

Microfluidic and lab-on-a-chip devices have attracted widespread interest in separation sciences and bioanalysis. Recent designs in microfluidic devices extend common separation concepts by exploiting new phenomena for molecular dynamics on a length scale of 10 mum and below, giving rise to novel manipulation tools and nonintuitive phenomena for microseparations. Here, we focus on three very recent developments for bioseparations based on tailored microfluidic systems: Single cell navigation, trapping and steering with subsequent on-chip lysis, protein separation and LIF detection (Section 3.1), then we report dielectrophoretic trapping and separation of large DNA fragments in structured microfluidic devices (Section 3.2). Finally, a paradoxial migration phenomenon based on thermal fluctuations, periodically arranged microchannels and a biased alternating current electric field is presented in Section 3.3.
MR-Apriori: Association Rules algorithm based on MapReduce (2014)

Traditional Association Rules algorithm has computing power shortage in dealing with massive datasets. In order to overcome these problems, a distributed association rules algorithm based on MapReduce programming model named MR-Apriori is proposed. In this paper, we introduce the MapReduce programming model of Hadoop platform and Apriori algorithm of data mining, propose the detailed procedure of MR-Apriori algorithm. Theoretical and experimental results show MR-Apriori algorithm make a sharp increase in efficiency.
Metric Relations and Displacement Groups in Mechanism and Robot Kinematics (1995)

This paper presents a systematic theory for metric relations between the invariant properties of displacement groups, and shows this theory application to mechanism kinematics. Displacement groups, their invariant properties and operations are briefly described. Kinematic constraints are then introduced as tools for relating abstract group properties to actual mechanism constraints. Criteria and operating rules to employ metric relations for the generation of a meaningful set of closure equations for kinematic chains are detailed.
Measurement of involved surface area in patients with psoriasis (1991)

Three methods of measuring the surface area of the involved skin were compared in 10 patients with psoriasis. Using the rule of nines, four untrained observers estimated the average extent of psoriasis as 20, 14, 23 and 33% of the body surface area. Measuring the area of tracings of plaque outlines using image analysis gave a mean involved surface area of 9% and image analysis of whole body photographs gave a mean value of 7%. We conclude that untrained observers using the rule of nines will overestimate the extent of psoriasis and that image analysis of whole body photographs is comparable to that of traced outlines.
METHYL BROMIDE ALTERNATIVES ON HORTICULTURAL CROPS (2000)

[EN] A very intensive crop rotation, with three to four crops per year, typical in Valencia,&#13;\nfrequently includes the earth almond Cyperus sculentus (Xufa) that acts as a real weed for&#13;\nthe next crop. Methyl bromide (MB) is the preferred fumigant to control both diseases&#13;\nand weeds in this kind of rotation.&#13;\nThe crop rotation begun by an escarole crop (September to January), followed by potato&#13;\n(February to May) and watermelon (May to August).&#13;\nDisinfestation treatments to compare were: 1) Non fumigated control; 2) Standard MB&#13;\npolyethylene (PE) 60g/ m2 ; 3) MB VIF 30g/ m2; 4) Solarization + Manure 5Kg/ m2; 5)&#13;\nSolarization + MS (N-Methyl Dithiocarbamate Sodic 40% p/v) 36g/ m2; 6) Telone C35&#13;\nMechanical application 40g/ m2; 7) Telone II (1,3-Dichloropropene 93%p/p)18g/ m2 +&#13;\nMS 108g/m2&#13;\nAll treatments are rather effective in controlling weeds when compared to the non treated&#13;\ncontrol, the increase in cost of removing weeds is particularly high if none treatment is&#13;\napplied.&#13;\nOnly the escarole crop suffered the attack of Scleotinia minar and treatments 2 and 7 gave&#13;\na very good protection as is revealed by a low percent of debris.&#13;\nNo specific pathogens were found in potato and watermelon crops, nevertheless grafting&#13;\nis confirmed as a very good technique that increases the yield of watermelon.&#13;\nSolarization treatments did not differ significantly from control in this experiment.&#13;\nTreatment 7 is as good as MB in sorne of the instances, but disinfestation with MB is&#13;\nabsolutely necessary if non grafted plants of watermelon are employed.
Absence of effect of sertraline on the pharmacokinetics and pharmacodynamics of phenytoin. (1996)

High dosages of setraline did not affect the pharmacokinetics or the pharmacodynamics of phenytoin in ths study performed in healthy volunteers.
Catalase, a novel antigen for Helicobacter pylori vaccination (1997)

The efficacy of an orogastric vaccine comprised of purified Helicobacter pylori catalase plus the mucosal adjuvant cholera toxin (CT) was examined with both the Helicobacter felis and H. pylori mouse models with BALB/c mice. Native H. pylori catalase (200 microg) plus CT was initially used as a vaccine antigen in the H. felis mouse model and protected 80% (8 of 10) of the challenged animals, while all control animals were infected (20 of 20). In a follow-up experiment, recombinant H. pylori catalase plus CT was used for immunization, and groups of mice were challenged with the Sydney strain of H. pylori. Immunization with recombinant catalase protected a significant proportion (9 of 10) of the mice from H. pylori challenge, indicating that this enzyme should be considered as a candidate for a future vaccine. This study provides the first available data on the efficacy of protective immunization with the new Sydney strain of H. pylori in a mouse model. These data also provide indirect evidence that proteins which are normally intracellular, such as catalase, may be present on the surface of H. pylori and thus may provide targets for immunization.
Fiberoptic Light for Oophorectomy at Vaginal Hysterectomy (1999)

Breach Candy Hospital, Sir Hurkisondas Nurrotamdas Hospital, and Sheth Nursing Home, Mumbai, India J Gynecol Surg 1998;14:119-122
Electrochemistry, spectroelectrochemistry, and photochemistry of a series of new covalently linked tris(2,2-bipyridine)ruthenium(II)/diquat complexes (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemistry, spectroelectrochemistry, and photochemistry of a series of new covalently linked tris(2,2-bipyridine)ruthenium(II)/diquat complexesC. Michael Elliott, Ruth A. Freitag, and David D. BlaneyCite this: J. Am. Chem. Soc. 1985, 107, 16, 4647–4655Publication Date (Print):August 1, 1985Publication History Published online1 May 2002Published inissue 1 August 1985https://pubs.acs.org/doi/10.1021/ja00302a009https://doi.org/10.1021/ja00302a009research-articleACS PublicationsRequest reuse permissionsArticle Views1396Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Low Rank Updates for the Cholesky Decomposition (2004)

Usage of the Sherman-Morrison-Woodbury formula to update linear systems after low rank modifications of the system matrix is widespread in machine learning. However, it is well known that this formula can lead to serious instabilities in the presence of roundoff error. If the system matrix is symmetric positive definite, it is almost always possible to use a representation based on the Cholesky decomposition which renders the same results (in exact arithmetic) at the same or less operational cost, but typically is much more numerically stable. In this note, we show how the Cholesky decomposition can be updated to incorporate low rank additions or downdated for low rank subtractions. We also discuss a special case of an indefinite update of rank two. The methods discussed here are well-known in the numerical mathematics literature, and code for most of them can be found in the LINPACK suite.
Free space optical communication link using a silicon photonic optical phased array (2015)

Many components for free space optical communication systems have shrunken in size over the last decade. However, the steering systems have remained large and power hungry. Non-mechanical beam steering offers a path to reducing the size of these systems. Optical phased arrays can allow integrated beam steering elements. One of the most important aspects of an optical phased array technology is its scalability to a large number of elements. Silicon photonics can potentially offer this scalability using CMOS foundry techniques. In this paper a small-scale silicon photonic optical phased array is demonstrated for both the transmitter and receiver functions in a free space optical link. The device using an array of thermo-optically controlled waveguide phase shifters and demonstrates one-dimensional steering with a single control electrode. Transmission of a digitized video data stream over the link is shown.
Cooperation in Multi-hop Cellular Networks (2003)

In multi-hop cellular networks, the existence of a communication link between the mobile station and the base station is not required: a mobile station that has no direct connection with a base station can use other mobile stations as relays. Compared with conventional (single-hop) cellular networks, this new generation can lead to a better usage of the available spectrum and to a reduction of infrastructure costs. However, these benefits would vanish if the mobile nodes do not properly cooperate and forward packets for other nodes. In this paper, we propose a charging and rewarding scheme to encourage the most fundamental operation, namely packet forwarding. We analyse the robustness of our protocols against rational and malicious attacks. We show that our protocols thwart rational attacks and detect malicious attacks. We also show that our solution makes collaboration rational for selfish nodes.
Amplification of the <i>put</i> genes and identification of the <i>put</i> gene products in <i>Escherichia</i> coli K12 (1980)

The utilization of L-proline as carbon or nitrogen source for the growth of Escherichia coli K12 requires the activities of an L-proline porter (PP-I) and a bifunctional L-proline dehydrogenase-delta1-pyrroline carboxylate dehydrogenase. PP-I is inactivated by mutations at putP and the bifunctional dehydrogenase is encoded in the adjacent locus, putA, at 22 min on the chromosome map. Two additional loci, proP (at 92 min) and proT (at 82 min), have also been implicated in L-proline transport. We have studied four ColE1/E. coli K12 hybrid plasmids from the plasmid bank prepared by Clarke and Carbon. Each of these plasmids was shown previously to complement an L-proline transport defect in E. coli. Genetic complementation analysis and biochemical assays of L-proline transport and L-proline dehydrogenase activity show that three of these hybrid plasmids bear the putPA region of the E. coli chromosome (plasmids pLC4-45, pLC10-29, and pLC43-41). The fourth plasmid, pLC35-38, specifically enhances the L-proline transport activity of its host bacteria but not their L-proline dehydrogenase activity. It probably encodes putP. We have used these plasmids in an E. coli minicell system to identify the putA and putP gene products.
Unsupervised Learning for Analyzing the Dynamic Behavior of Online Banking Fraud (2013)

In many cases, databases are in constant evolution, new data is arriving continuously. Data streams pose several unique problems that make obsolete the applications of classical data analysis methods. Indeed, these databases are constantly on-line, growing with the arrival of new data. In addition, the probability distribution associated with the data may change over time. In online banking, fraud is one of the major ethical issues. For this challenge, the main aims of the data mining approaches are, firstly, to identify the different types of credit card fraud, and, secondly, for the fraud detection. We propose in this paper a method of synthetic representation of the data structure for efficient storage of information, and a measure of dissimilarity between these representations for the detection of change in the stream structure, in order to detect different types of fraud during the a period of time. The proposed approach was validated on a real application for the on-line credit card fraud detection.
Wrap53, a novel regulator of p53 (2009)

Natural antisense transcripts are a group of regulatory RNAs whose existence has been known for a long time but whose functional significance is still relatively unknown. Studies indicate that a large fraction of all mammalian genes may be regulated by antisense transcripts suggesting a central role of this regulation in eukaryotic gene expression. Wrap53 is a natural antisense transcript of p53 that regulates endogenous p53 mRNA levels and is furthermore required for induction of p53 protein by targeting the 5'untranslated region of p53 mRNA. Our discovery of Wrap53 demonstrates for the first time that an antisense transcript has an essential role in the regulation of p53 mRNA. This finding provides important new insight into p53 regulation and the mechanism of antisense-mediated gene regulation in human cells.
Divide-and-Conquer Frontier Search Applied to Optimal Sequence Alignment (2000)

We present a new algorithm that reduces the space complexity of heuristic search. It is most e ective for problem spaces that grow polynomially with problem size, but contain large numbers of short cycles. For example, the problem of nding an optimal global alignment ofseveral DNA or amino-acid sequences can be solved by nding a lowest-cost corner-to-corner path in a d-dimensional grid. A previous algorithm, called divide-and-conquer bidirectional search (Korf 1999), saves memory by storing only the Open lists and not the Closed lists. We show that this idea can be applied in a unidirectional search aswell. This extends the technique to problems where bidirectional search is not applicable, and is more e cient in both time and space than the bidirectional version. If n is the length of the strings, and d is the number of strings, this algorithm can reduce the memory requirement from O(n d) to O(n d;1). While our current implementation of DCFS is somewhat slower than existing dynamic programming approaches for optimal alignment of multiple gene sequences, DCFS is a more general algorithm 1
Learning about objects with human teachers (2009)

A general learning task for a robot in a new environment is to learn about objects and what actions/effects they afford. To approach this, we look at ways that a human partner can intuitively help the robot learn, Socially Guided Machine Learning. We present experiments conducted with our robot, Junior, and make six observations characterizing how people approached teaching about objects. We show that Junior successfully used transparency to mitigate errors. Finally, we present the impact of "social" versus "non-social" data sets when training SVM classifiers.
Tumor pH and Its Measurement (2010)

Studies over the last few decades have demonstrated that the intracellular pH of solid tumors is maintained within a range of 7.0-7.2, whereas the extracellular pH is acidic. A low extracellular pH may be an important factor inducing more aggressive cancer phenotypes. Research into the causes and consequences of this acidic pH of tumors is highly dependent on accurate, precise, and reproducible measurements, and these have undergone great changes in the last decade. This review focuses on the most recent advances in the in vivo measurement of tumor pH by pH-sensitive PET radiotracers, MR spectroscopy, MRI, and optical imaging.