gebhart/patrepeval huggingface dataset:
Development of Hexaaluminate Catalysts for Combustion of Gasified Biomass in Gas Turbines (2002)

Abstract There is an increasing interest in catalytic combustors fuelled by low-heating value (LHV) gases, with a LHV of 5–7 MJ/Nm3. This is because catalytic combustion could be advantageous compared to flame combustion with respect to stable combustion of LHV-gases and low conversions of fuel-N (mainly NH3) to NOX. In the present project, funded by the EU Joule Program, catalytic combustion of gasified wood for gas turbine applications is studied. A synthetic gas mixture of H2, CO, CO2,H2O,CH4,N2, and NH3, that resembles the output from a fluidized bed gasifier using biomass as raw material, is used. The gas mixture is mixed with air at atmospheric pressure and combusted over washcoated cordierite monoliths in a bench-scale laboratory quartz-reactor. The objectives of the work described here are twofold. To begin with, improvement of the thermal stability of hexaaluminate washcoats by substitutions of rare earth or transition metal compounds is being studied. Secondly, catalytic combustion of gasified biomass over these washcoats has been studied in a bench-scale unit. In this on-going project, obtained result show that it is possible to improve the surface area of hexaaluminate compounds up to 17 m2/g after careful synthesis and calcination up to 1400°C for four hours. The selectivity of NH3-conversion to N2 is at present at 60 percent, but varies strongly with temperature. Fuel components such as H2, CO, C2H4, and NH3 ignite at temperatures close to compressor outlet temperatures. This means that a pilot-flame may not be needed for ignition of the fuel. A comparison between a Pd-impregnated lanthanum hexaaluminate and a Mn-substituted lanthanum hexaaluminate showed that the ignition temperature and the NOX-formation varied strongly over the two different catalysts.
Studies on the synthesis of some styryl‐3‐cyano‐2(1<i>H</i>)‐pyridinethiones and polyfunctionally substituted 3‐aminothieno[2,3‐<i>b</i>]‐pyridine derivatives (1995)

Abstract The 3‐cyano‐4,6‐dimethyl‐2(1 H )‐pyridinethione was condensed with benzaldehyde in basic solution leads to styryl‐3‐cyano‐2(1 H )‐pyridinethiones. Treatment of cinnamicaldehyde with cyanothioacetamide to give cinnamylidencyanothioacetamide, which can be cyclized with the appropriate ketones to afford the 3‐cyano‐5,6‐polymethylene‐4‐styryl‐2(1 H )‐pyridinethione derivatives. The polyfunctionally substituted 3‐aminothieno[2,3‐ b ]pyridine derivatives were obtained in good yield by cyclization of 3‐cyano‐2(1 H )‐pyridinethione derivatives with appropriate α‐halogeno carbonyl compounds and nitrile, respectively.
Improved strategy in analytic surface calculation for molecular systems: Handling of singularities and computational efficiency (1993)

Abstract Computer methods for analytic surface calculations of molecular systems suffer from numerical instabilities and are CPU time consuming. In this article, we present proposals toward the solution of both problems. Singularities arise when nearly collinear triples of neighboring atoms or multiple vertices are encountered during the calculation. Topological decisions in analytic surface calculation algorithms (accessibility of vertices and arcs) are based upon the comparison of distances or angles. If two such numbers are nearly equal, then currently used computer programs may not resolve this ambiguity correctly and can subsequently fail. In this article, modifications in the analytic surface calculation algorithm are described that recognize singularities automatically and treat them appropriately without restarting parts of the computation. The computing time required to execute these alterations is minimal. The basic modification consists in defining an accuracy limit within which two values may be assumed as equal. The search algorithm has been reformulated to reduce the computational effort. A new set of formulas makes it possible to avoid mostly the extraction of square roots. Tests for small‐and medium‐sized intersection circles and for pairs of vertices with small vertex height help recognize fully buried circles and vertex pairs at an early stage. The new program can compute the complete topology of the surface and accessible surface area of the protein crambin in 1.50–4.29 s (on a single R3000 processor of an SGI 4D/480) depending on the compactness of the conformation where the limits correspond to the fully extended or fully folded chain, respectively. The algorithm, implemented in a computer program, will be made available on request. © John Wiley &amp; Sons, Inc.
Monoclonal Antibody to Fibrin D-Dimer (DD-3B6) Recognizes an Epitope on the γ-Chain of Fragment D (1988)

Laboratory determination of fibrinolysis has been facilitated by diagnostic tests that use monoclonal antibody DD-3B6 to measure fibrin D-dimer levels in plasma. When DD-3B6 is reacted with soluble fibrin fragments, it is specific for fragment D-dimer. The authors have used immunoblot analysis of DD-3B6 binding to purified fragment D and fragment D-dimer to localize the binding site of the antibody. Although DD-3B6 recognizes only fragment D-dimer in solution, it binds to both immobilized fragment D-dimer and fragment D in immunoblots. When immunoblots were performed using protein which was electrophoresed under reducing conditions, DD-3B6 bound to the gamma-chain of fragments D1, D2, and D3. Therefore, the epitope recognized by DD-3B6 resides between amino acids 86 and 302 in the gamma-chain of fragment D. This epitope is masked in soluble non-cross-linked or nondegraded fibrin, but becomes expressed after cross-linked fibrin has been cleaved by plasmin.
Therapeutic interactions between stathmin inhibition and chemotherapeutic agents in prostate cancer (2006)

Limitations of prostate cancer therapy may be overcome by combinations of chemotherapeutic agents with gene therapy directed against specific proteins critical for disease progression. Stathmin is overexpressed in many types of human cancer, including prostate cancer. Stathmin is one of the key regulators of the microtubule network and the mitotic spindle and provides an attractive therapeutic target in cancer therapy. We recently showed that adenovirus-mediated gene transfer of anti-stathmin ribozyme could suppress the malignant phenotype of prostate cancer cells in vitro. In the current studies, we asked whether the therapeutic effects of stathmin inhibition could be further enhanced by exposure to different chemotherapeutic agents. Exposure of uninfected LNCaP human prostate cancer cells or cells infected with a control adenovirus to Taxol, etoposide, 5-fluorouracil (5-FU), or Adriamycin resulted in modest decrease in proliferation and clonogenicity. Interestingly, exposure of cells infected with an anti-stathmin adenovirus to Taxol or etoposide resulted in a complete loss of proliferation and clonogenicity, whereas exposure of the same cells to 5-FU or Adriamycin potentiated the growth-inhibitory effects of the anti-stathmin ribozyme, but the cells continued to proliferate. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling analysis of uninfected cells or cells infected with a control adenovirus showed modest induction of apoptosis in the presence of different drugs. In contrast, cells infected with the anti-stathmin adenovirus showed a marked increase in apoptosis on exposure to Taxol or etoposide and a modest increase on exposure to 5-FU or Adriamycin. Overall, the effects of combinations of anti-stathmin ribozyme with Taxol or etoposide were synergistic, whereas the effects of combinations of anti-stathmin ribozyme with 5-FU or Adriamycin were additive. Moreover, triple combination of anti-stathmin ribozyme with low noninhibitory concentrations of Taxol and etoposide resulted in a profound synergistic inhibition of proliferation, clonogenicity, and marked induction of apoptosis. This synergy might be very relevant for the treatment of prostate cancer because Taxol and etoposide are two of the most effective agents in this disease. Thus, this combination may provide a novel form of prostate cancer therapy that would avoid toxicities associated with the use of multiple chemotherapeutic agents at full therapeutic doses.
Simple and fault-tolerant key agreement for dynamic collaborative groups (2000)

Secure group communication is an increasingly popular research area having received much attention in recent years. The fundamental challenge revolves around secure and efcient group key management. While centralized methods are often appropriate for key distribution in large groups, many collaborative group settings require distributed key agreement techniques. This work investigates a novel approach to group key agreement by blending binary key trees with DiAEe-Hellman key exchange. The resultant protocol suite is very simple, secure and fault-tolerant. Moreover, its eAEciency surpasses that of prior art.
Promoters of the rolA, B, and C genes of Agrobacterium rhizogenesare differentially regulated in transgenic plants. (1989)

Chimeric genes containing the beta-glucuronidase reporter gene under the control of the rolA, B, and C promoters of Agrobacterium rhizogenes are expressed in a regulated manner in transgenic plants. The intergenic region separating the rolB and C genes represents a bidirectional promoter. This bidirectional promoter regulates transcription for both genes in a similar fashion in aerial organs of the plants, but in a distinct way in roots. Moreover, both rolB and C promoter activities differ from those characteristic of the rolA promoter. Thus, promoters of bacterial origin show differential expression in transgenic plants, and regulation of roI gene expression plays a role in the biological effects caused by the rolA, B, and C genes.
I. Ligand transfer of halides (chloride, bromide, iodide) and pseudohalides (thiocyanate, azide, cyanide) from copper(II) to alkyl radicals (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTI. Ligand transfer of halides (chloride, bromide, iodide) and pseudohalides (thiocyanate, azide, cyanide) from copper(II) to alkyl radicalsJ. K. Kochi and C. L. JenkinsCite this: J. Org. Chem. 1971, 36, 21, 3095–3102Publication Date (Print):October 1, 1971Publication History Published online1 May 2002Published inissue 1 October 1971https://pubs.acs.org/doi/10.1021/jo00820a008https://doi.org/10.1021/jo00820a008research-articleACS PublicationsRequest reuse permissionsArticle Views578Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High contrast 40Gbit/s optical modulation in silicon (2011)

Data interconnects are on the verge of a revolution. Electrical links are increasingly being pushed to their limits with the ever increasing demand for bandwidth. Data transmission in the optical domain is a leading candidate to satisfy this need. The optical modulator is key to most applications and increasing the data rate at which it operates is important for reducing power consumption, increasing channel bandwidth limitations and improving the efficiency of infrastructure usage. In this work silicon based devices of lengths 3.5mm and 1mm operating at 40Gbit/s are demonstrated with extinction ratios of up to 10dB and 3.5dB respectively. The efficiency and optical loss of the phase shifter is 2.7V.cm and 4dB/mm (or 4.5dB/mm including waveguide loss) respectively.
Automated, High-Throughput Assays for Evaluation of Human Pancreatic Islet Function (2007)

An important challenge in pancreatic islet transplantation in association with type 1 diabetes is to define automatic high-throughput assays for evaluation of human islet function. The physiological techniques presently used are amenable to small-scale experimental samples and produce descriptive results. The postgenomic era provides an opportunity to analyze biological processes on a larger scale, but the transition to high-throughput technologies is still a challenge. As a first step to implement high-throughput assays for the study of human islet function, we have developed two methodologies: multiple automated perifusion to determine islet hormone secretion and high-throughput kinetic imaging to examine islet cellular responses. Both technologies use fully automated devices that allow performing simultaneous experiments on multiple islet preparations. Our results illustrate that these technologies can be applied to study the functional status and explore the pharmacological profiles of islet cells. These methodologies will enable functional characterization of human islet preparations before transplantation and thereby provide the basis for the establishment of predictive tests for beta-cell potency.
Prevalence of mutations in genes associated with rifampicin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates (2017)

<i>Purpose</i>: To analyze prevalence of mutations in genes associated with rifampicin and isoniazid resistance in <i>Mycobacterium tuberculosis</i> clinical isolates from patients with possible MDR TB of Puducherry, South India and to explore the association of specific mutations conferring rifampicin (RIF) resistance. <i>Methods</i>: We performed a commercial Genotype MDBDRplus V.2.0 assay for the rapid detection of rifampicin and isoniazid resistance directly on sputum specimens of patients with possible MDR TB. <i>Results</i>: Totally 558 multidrug resistant, 293 RIF mono resistant and 923 INH mono resistant tuberculosis were detected from the 12,786 patients with possible MDR TB samples. The 50.5% mutations were observed in the region of S531L in MDR TB patients and 55.6% in rifampicin monoresistant cases. In total isoniazid monoresistant, 68.0% mutations were detected in <i>katG</i> gene, which is more prevalent in comparison to <i>inhA</i> gene 32.0%. There were about 57.9% and 32.2% MDR TB cases diagnosed in the age group of > 15 to ≤ 45 years and > 45 to ≤ 60 years respectively. <i>Conclusions</i>: The rate of occurrences of mutations were found widely in the Rifampicin Resistant Determination Region (81 bp) of <i>rpoB</i> gene and the hypervariable region 530-533 codons of rpoB gene is alarming in the specification. The higher frequency of mutation in codons of <i>rpoB</i> (S531L) and <i>katG</i> (S315T) gene help to design simple, new and less expensive molecular techniques to use in peripheral laboratories.
Antibody–Drug Conjugates (ADCs) for Personalized Treatment of Solid Tumors: A Review (2017)

Attaching a cytotoxic "payload" to an antibody to form an antibody-drug conjugate (ADC) provides a mechanism for selective delivery of the cytotoxic agent to cancer cells via the specific binding of the antibody to cancer-selective cell surface molecules. The first ADC to receive marketing authorization was gemtuzumab ozogamicin, which comprises an anti-CD33 antibody conjugated to a highly potent DNA-targeting antibiotic, calicheamicin, approved in 2000 for treating acute myeloid leukemia. It was withdrawn from the US market in 2010 following an unsuccessful confirmatory trial. The development of two classes of highly potent microtubule-disrupting agents, maytansinoids and auristatins, as payloads for ADCs resulted in approval of brentuximab vedotin in 2011 for treating Hodgkin lymphoma and anaplastic large cell lymphoma, and approval of ado-trastuzumab emtansine in 2013 for treating HER2-positive breast cancer. Their success stimulated much research into the ADC approach, with >60 ADCs currently in clinical evaluation, mostly targeting solid tumors. Five ADCs have advanced into pivotal clinical trials for treating various solid tumors-platinum-resistant ovarian cancer, mesothelioma, triple-negative breast cancer, glioblastoma, and small cell lung cancer. The level of target expression is a key parameter in predicting the likelihood of patient benefit for all these ADCs, as well as for the approved compound, ado-trastuzumab emtansine. The development of a patient selection strategy linked to target expression on the tumor is thus critically important for identifying the population appropriate for receiving treatment.
<i>Xid</i>immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease (1991)

Infection of several mouse strains with Trypanosoma cruzi stimulates high levels of T and B lymphocyte activities which persist during the chronic phase and is followed by specific immunosuppression and severe autoimmune pathology. Infected BALB.Xid mice carrying an X-linked mutation and lacking CD5 B cells, display poor B cell responses to T. cruzi infection, accompanied by low levels of specific and non-specific immunoglobulins in the serum. However, these animals control parasitemia, do not show the wasting observed in BALB/c mice, and develop almost no pathology early in the chronic phase. The infection of (BALB.Xid female x BALB/c male) F1 animals shows that immunodefective males behave like Xid animals in contrast to females which respond as normal BALB/c mice. These results indicate that the Xid locus controls lymphocyte responses, parasite clearance and pathology in experimental Chagas' disease.
Highly Sensitive Near-Infrared Fluorescent Probes for Nitric Oxide and Their Application to Isolated Organs (2005)

Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.
NMR Spectroscopy Techniques for Screening and Identifying Ligand Binding to Protein Receptors (2003)

Binding events of ligands to receptors are the key for an understanding of biological processes. Gaining insight into protein-protein and protein-ligand interactions in solution has recently become possible on an atomic level by new NMR spectroscopic techniques. These experiments identify binding events either by looking at the resonance signals of the ligand or the protein. Ideally, both techniques together deliver a complete picture of ligand binding to a receptor. The approaches discussed in this review allow screening of compound libraries as well as a detailed identification of the groups involved in the binding events. Also, characterization of the binding strength and kinetics is possible, competitive binding as well as allosteric effects can be identified, and it has even been possible to identify ligand binding to intact viruses and membrane-bound proteins.
Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer (2008)

Protein expression of human toll-like receptors (TLR) 1-10 was measured in cell lines and solid tumors of head and neck squamous cell carcinoma (HNSCC). All HNSCC cell lines and 80% of solid tumors were found to express TLR3 as a predominantly intracellular protein, while no other TLR proteins were expressed. TLR3 has previously been shown to contribute to the activation of nuclear factor-κB (NF-κB), a transcription factor which promotes several types of human cancers. Significantly, NF-κB expression was strongest in protein extracts from carcinoma tissue in which TLR3 was overexpressed. Inhibition of TLR3 expression in permanent HNSCC cell lines resulted in decreased expression of the oncoprotein c-Myc resulting in decreased cell proliferation. Correspondingly, overexpression of human TLR3 in mouse fibroblasts resulted in an upregulation of c-Myc and increased sensitivity for PolyI:C-induced cell proliferation. Our data suggest that TLR3 contributes to the malignant phenotype leading to invasive carcinoma in HNSCC.
An automated design flow for 3D microarchitecture evaluation (2006)

Although the emerging three-dimensional integration technology can significantly reduce interconnect delay, chip area, and power dissipation in nanometer technologies, its impact on overall system performance is still poorly understood due to the lack of tools and systematic flows to evaluate 3D microarchitectural designs. The contribution of this paper is the development of MEVA-3D, an automated physical design and architecture performance estimation flow for 3D architectural evaluation which includes 3D floorplanning, routing, interconnect pipelining and automated thermal via insertion, and associated die size, performance, and thermal modeling capabilities. We apply this flow to a simple, out-of-order superscalar microprocessor to evaluate the performance and thermal behavior in 2D and 3D designs, and demonstrate the value of MEVA-3D in providing quantitative evaluation results to guide 3D architecture designs. In particular, we show that it is feasible to manage thermal challenges with a combination of thermal vias and double-sided heat sinks, and report modest system performance gains in 3D designs for these simple test examples.
Regulatory roles for L-arginine in reducing white adipose tissue (2012)

As the nitrogenous precursor of nitric oxide, L-arginine regulates multiple metabolic pathways involved in the metabolism of fatty acids, glucose, amino acids, and proteins through cell signaling and gene expression. Specifically, arginine stimulates lipolysis and the expression of key genes responsible for activation of fatty acid oxidation to CO2 and water. The underlying mechanisms involve increases in the expression of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), mitochondrial biogenesis, and the growth of brown adipose tissue growth. Furthermore, arginine regulates adipocyte-muscle crosstalk and energy partitioning via the secretion of cytokines and hormones. In addition, arginine enhances AMP-activated protein kinase (AMPK) expression and activity, thereby modulating lipid metabolism and energy balance toward the loss of triacylglycerols. Growing evidence shows that dietary supplementation with arginine effectively reduces white adipose tissue in Zucker diabetic fatty rats, diet-induced obese rats, growing-finishing pigs, and obese patients with type II diabetes. Thus, arginine can be used to prevent and treat adiposity and the associated metabolic syndrome.
The fast multipole method for the wave equation: a pedestrian prescription (1993)

A practical and complete, but not rigorous, exposition of the fact multiple method (FMM) is provided. The FMM provides an efficient mechanism for the numerical convolution of the Green's function for the Helmholtz equation with a source distribution and can be used to radically accelerate the iterative solution of boundary-integral equations. In the simple single-stage form presented here, it reduces the computational complexity of the convolution from O(N/sup 2/) to O(N/sup 3/2/), where N is the dimensionality of the problem's discretization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>