gebhart/patrepeval huggingface dataset:
Automatic recognition of ISAR ship images (1996)

Inverse synthetic aperture radar (ISAR) produces images of ships at sea which human operators can be trained to recognize. Because ISAR uses the ship's own varying angular motions (roll, pitch, and yaw) for cross-range resolution, the viewing aspect and cross-range scale factor are continually changing on time scales of a few seconds. This and other characteristics of ISAR imaging make the problem of automatic recognition of ISAR images quite distinct from the recognition of optical images. The nature of ISAR imaging of ships, and single-frame and multiple-frame techniques for segmentation, feature extraction, and classification are described. Results are shown which illustrate a capability for automatic recognition of ISAR ship imagery.
A New High-Temperature Superconductor: Bi <sub>2</sub> Sr <sub>3-x</sub> Ca <sub>x</sub> Cu <sub>2</sub> O <sub>8+y</sub> (1988)

A new superconductor that displays onset behavior near 120 K has been identified as Bi(2)Sr(3-x)Ca(x)Cu(2)O(8+y), with x ranging from about 0.4 to 0.9. Single crystal x-ray diffraction data were used to determine a pseudo-tetragonal structure based on an A-centered orthorhombic subcell with a = 5.399 A, b= 5.414A, and c = 30.904 A. The structure contains copper-oxygen sheets as in La(2)CuO(4) and YBa(2)Cu(3)O(7), but the copper-oxygen chains present in YBa(2)Cu(3)O(7) do not occur in Bi(2)Sr(3-x)Ca(x)Cu(2)O(8+y). The structure is made up of alternating double copper-oxygen sheets and double bismuth-oxygen sheets. There are Ca(2+) and Sr(2+) cations between the adjacent Cu-O sheets; Sr(2+) cations are also found between the Cu-O and Bi-O sheets. Electron microscopy studies show an incommensurate superstructure along the a axis that can be approximated by an increase of a factor of 5 over the subcell dimension. This superstructure is also observed by x-ray diffraction on single crystals, but twinning can make it appear that the superstructure is along both a and b axes. Flux exclusion begins in our samples at about 116 K and is very strong by 95 K. Electrical measurements on a single crystal of Bi(2)Sr(3-x)Ca(x)Cu(2)O(8+y) show a resistivity drop at about 116 K and apparent zero resistivity at 91 K.
Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume (2010)

Hippocampal volume shrinks in late adulthood, but the neuromolecular factors that trigger hippocampal decay in aging humans remains a matter of speculation. In rodents, brain-derived neurotrophic factor (BDNF) promotes the growth and proliferation of cells in the hippocampus and is important in long-term potentiation and memory formation. In humans, circulating levels of BDNF decline with advancing age, and a genetic polymorphism for BDNF has been related to gray matter volume loss in old age. In this study, we tested whether age-related reductions in serum levels of BDNF would be related to shrinkage of the hippocampus and memory deficits in older adults. Hippocampal volume was acquired by automated segmentation of magnetic resonance images in 142 older adults without dementia. The caudate nucleus was also segmented and examined in relation to levels of serum BDNF. Spatial memory was tested using a paradigm in which memory load was parametrically increased. We found that increasing age was associated with smaller hippocampal volumes, reduced levels of serum BDNF, and poorer memory performance. Lower levels of BDNF were associated with smaller hippocampi and poorer memory, even when controlling for the variation related to age. In an exploratory mediation analysis, hippocampal volume mediated the age-related decline in spatial memory and BDNF mediated the age-related decline in hippocampal volume. Caudate nucleus volume was unrelated to BDNF levels or spatial memory performance. Our results identify serum BDNF as a significant factor related to hippocampal shrinkage and memory decline in late adulthood.
Bio-integrated electronics (2014)

Strategies for bio-integrated electronics must overcome challenges associated with the mismatch between the hard, planar surfaces of brittle semiconductor wafers and the soft, curvilinear tissues of timely dynamic biological systems. This paper discusses the successful structural design, fabrication and bio-integration of tissue-like electronics that can intimately conform to biological tissues and deform with the tissues in a mechanically invisible manner. Examples including epidermal electronics, instrumented balloon catheters, and smart finger tubes will be discussed to manifest our multidisciplinary research at the boundary of electronics, mechanics, materials, and biomedicine.
On the degrees of freedom of scattered fields (1989)

Starting from the observation that fields differing less than a prescribed error cannot be resolved as distinct entities, the degrees of freedom of the scattered field are introduced and then computed. The degrees of freedom are shown to be practically equal to the Nyquist number appropriate to the effective (spatial) bandwidth of the scattered field and to the extension of the observation domain. Accordingly, a finite number of elements of information can be used to determine the scattered field to a prescribed approximation error. It is also shown that the field representation can be made in terms of field values and simple sampling functions, provided that a marginal increase in the approximation error is tolerated. The results not only completely justify the use of sampling interpolation for representing scattering fields, but also demonstrate that such representation is practically an optimal one. An algorithm for the reconstruction of scattered fields, given the maximum allowed error, is then produced.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Epstein-Barr virus DNA in nasopharyngeal carcinomas from Chinese patients in Hong Kong. (1992)

EBV genome is present in appreciable copy number in most cases of well differentiated NPC in Chinese patients in Hong Kong.
Lineage of neurons and glia in chick dorsal root ganglia: analysis <i>in vivo</i> with a recombinant retrovirus (1991)

We used retrovirus-mediated gene transfer to study the lineage of neural crest cells in chick embryos. Individual crest cells were infected before they migrated from the neural tube, and their clonal progeny were subsequently revealed in sensory ganglia and associated structures by a histochemical stain for the viral gene product (lacZ). We found that crest cells were multipotential in several respects. (1) Many clones contained both ventrolateral (VL) and dorsomedial (DM) neurons, which had been suggested to be lineally distinct. (2) Many clones contained both large and small neurons, which are known to innervate distinct targets. (3) Many clones contained multiple glial subtypes, e.g. both Schwann cells, which ensheath axons, and satellite cells, which ensheath neuronal somata. (4) Many clones contained both neurons and glial cells. On the other hand, a sizeable minority of clones was homogenous, e.g. they contained only neurons or only glial cells--suggesting that some progenitors may be, or become, restricted in potential. Finally, this study provides the first opportunity to compare directly the two methods currently available for tracing cell lineage in vertebrate embryos, retroviral infection and tracer injection: our results and those of Bronner-Fraser and Fraser (1989), who used the latter method, provide complementary but consistent views of crest lineage.
&lt;title&gt;New digital detector for projection radiography&lt;/title&gt; (1995)

The operational principle of a new, patented digital radiographic system using a multi-layer structure consisting of a thin-film pixel array, selenium x-ray photoconductor, dielectric layer and top electrode is described. Under an applied electric field, a diagnostic x-ray signal is obtained by the direct conversion of x-ray energy to electron-hole pairs which are collected as electrical charges by individual storage capacitor associated with each pixel element. The electronic readout sequence is initiated immediately after the x-ray exposure, and in several seconds, the image data is available for display on a video monitor, for data storage, data transmission, and hard copy generation. Signal strength of this direct conversion method is estimated to be significantly higher than that of other indirect conversion methods where light is first generated using a scintillator or phosphor and then detected by charge-coupled devices (CCDs) or thin-film-transistor (TFT) arrays in conjunction with photodiodes. In addition, since charges generated by x-ray photons move mostly along the direction of the bias electric field, images of very high spatial resolution can be obtained. The resolution limits are principally defined by the smallest pixel that can be manufactured. Recent x-ray images obtained from experimental detector panels are presented. X-ray sensitivity, dynamic range, signal-to-noise ratio, and spatial resolution are discussed.
Deep learning in holography and coherent imaging (2019)

Recent advances in deep learning have given rise to a new paradigm of holographic image reconstruction and phase recovery techniques with real-time performance. Through data-driven approaches, these emerging techniques have overcome some of the challenges associated with existing holographic image reconstruction methods while also minimizing the hardware requirements of holography. These recent advances open up a myriad of new opportunities for the use of coherent imaging systems in biomedical and engineering research and related applications.
Multiple neuropeptides stimulate clonal growth of small cell lung cancer: effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin. (1991)

We tested whether Ca(2+)-mobilizing neuropeptides can function as growth factors for small cell lung carcinoma cells. The neuropeptides bradykinin, neurotensin, cholecystokinin, and vasopressin at nanomolar concentrations stimulated a rapid and transient increase in the intracellular concentration of Ca2+. Crucially, these peptides in the same concentration range also caused a marked increase in colony formation in semisolid medium in responsive small cell lung carcinoma cell lines. At optimal concentrations bradykinin, neurotensin, cholecystokinin, vasopressin, galanin, and gastrin-releasing peptide were equally effective in promoting clonal growth. These findings support the hypothesis that small cell lung carcinoma growth is sustained by an extensive network of autocrine and paracrine interactions involving multiple neuropeptides.
New topics in bradykinin research (2011)

Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B(1) and B(2) receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.
Inactivation of rabies virus in reagents used for the fluorescent rabies antibody test (1982)

Procedures for inactivating rabies virus in reagents used for the fluorescent rabies antibody test are described. Mouse brain adsorbing suspensions containing greater than or equal to 10(9) 50% lethal doses of virus per ml were rendered noninfectious by treatment with 0.1% beta-propiolactone or by heating at 56 degrees for greater than or equal to 30 min. Viable virus in tissue impression smears was inactivated by acetone fixation at 50 degrees C for greater than or equal to 30 min or by immersion in 0.1% beta-propiolactone at 37 degrees C for 2 h. Inactivated reagents gave specific and sensitive reactions in the fluorescent rabies antibody test.
Resource allocation in distributed factory scheduling (1991)

A distributed factory scheduling model that is based on the concept of constraint-directed search within a centralized framework is presented. A set of texture measures that quantify several characteristics of the problem space being searched has been developed into heuristics that direct the searches conducted by scheduling agents. The heuristics have been used to direct the searches of a centralized activity-based scheduler, achieving good schedule quality and minimizing the likelihood of backtracking. The model discussed uses textures to direct distributed scheduling, optimizing decisions in the global search space by allowing agents to focus and direct searches in their individual search spaces. Experimental results are presented and confirm the effectiveness of the approach.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Reversion to neurovirulence of the live-attenuated Sabin type 3 oral pollovirus vaccine (1984)

The complete nucleotide sequence has been determined of a strain of poliovirus type 3, P3/119, isolated from the central nervous system of a victim of fatal vaccine-associated poliomyelitis. Comparison of this sequence with those obtained previously for the Sabin type 3 vaccine, P3/Leon 12a1b and its neurovirulent progenitor, P3/Leon/37, reveals that these three strains are on a direct geneaological lineage and therefore that P3/119 is a bona fide revertant of the vaccine. P3/119 differs in sequence from its attenuated vaccine parent at just seven positions. Only one of these differences, a mutation from U to C at position 472 in the presumed noncoding region of the genome, is a back mutation to the wild type sequence. Of the six other differences, three give rise to coding changes in virus structural proteins, two are silent changes in the major open reading frame of the genome and one affects the 3'-terminus just prior to the poly A tract. These differences indicate that there are three possible types of molecular change which could, singly or collectively, result in attenuation and reversion to neurovirulence of the Sabin type 3 vaccine.
Semi-supervised speech act recognition in emails and forums (2009)

In this paper, we present a semi-supervised method for automatic speech act recognition in email and forums. The major challenge of this task is due to lack of labeled data in these two genres. Our method leverages labeled data in the Switchboard-DAMSL and the Meeting Recorder Dialog Act database and applies simple domain adaptation techniques over a large amount of unlabeled email and forum data to address this problem. Our method uses automatically extracted features such as phrases and dependency trees, called subtree features, for semi-supervised learning. Empirical results demonstrate that our model is effective in email and forum speech act recognition.
Methodologies for immersive robot programming in an augmented reality environment (2006)

10.1145/1174429.1174470
Oligonucleotide Melting Temperatures under PCR Conditions: Nearest-Neighbor Corrections for Mg2+, Deoxynucleotide Triphosphate, and Dimethyl Sulfoxide Concentrations with Comparison to Alternative Empirical Formulas (2001)

This robust model, accounting for the effects of Mg(2+), DMSO, and dNTPs on oligonucleotide T(m) in PCR, gives reliable T(m) predictions using thermodynamic N-N calculations or empirical formulas.
An Open-Label Naturalistic Pilot Study of Acamprosate in Youth with Autistic Disorder (2011)

To date, placebo-controlled drug trials targeting the core social impairment of autistic disorder (autism) have had uniformly negative results. Given this, the search for new potentially novel agents targeting the core social impairment of autism continues. Acamprosate is U.S. Food and Drug Administration-approved drug to treat alcohol dependence. The drug likely impacts both gamma-aminobutyric acid and glutamate neurotransmission. This study describes our initial open-label experience with acamprosate targeting social impairment in youth with autism. In this naturalistic report, five of six youth (mean age, 9.5 years) were judged treatment responders to acamprosate (mean dose 1,110 mg/day) over 10 to 30 weeks (mean duration, 20 weeks) of treatment. Acamprosate was well tolerated with only mild gastrointestinal adverse effects noted in three (50%) subjects.
PCSK9 REGULATES LDLR-MEDIATED UPTAKE OF LIPOPOLYSACCHARIDE AND LIPOTEICHOIC ACID (2017)

The liver regulates inflammation during sepsis, and most liver functions are carried out by hepatocytes. Bacterial lipids, including lipopolysaccharide (LPS) and lipoteichoic acid (LTA), can be cleared by hepatocytes, but the underlying mechanisms are uncertain. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates uptake of LPS by hepatocytes, but it is unknown whether LTA uptake is similarly regulated. Therefore, our objectives were to characterize the PCSK9-regulated pathway of bacterial lipid uptake by hepatocytes by identifying whether low-density lipoprotein (LDL) receptor (LDLR) and LDLR-related protein 1 (LRP1) are the target receptors, and by determining which lipoproteins are involved. To study this pathway, we assessed the uptake of fluorescently-labeled LPS or LTA by human HepG2 hepatocytes using flow cytometry. We pre-treated HepG2 cells with PCSK9, alone or in combination with anti-LDLR or anti-LRP1 antibodies, in order to identify the PCSK9-regulated receptors that are involved, and utilized media containing normal serum or lipoprotein-deficient serum to investigate the lipoprotein- dependence of this pathway. We also determined the roles of LDL and HDL in bacterial lipid uptake through a series of add-back experiments to lipoprotein-deficient serum, and blocked LDLR to confirm that LDLR mediates LDL-dependent uptake. The HepG2 cell response to variable degrees of bacterial lipid uptake was also assessed in a subset of experiments by measuring several cytokines and extracellular alanine aminotransferase (ALT) activity in the cell culture supernatant. We found that PCSK9 regulates LDLR-mediated uptake of both LPS and LTA through an LDL-dependent mechanism, while LRP1 is not involved. Increased bacterial lipid uptake did not result in any hepatocellular injury or cytokine production, as measured by ALT activity and interleukin (IL)-6, IL-8, IL-10, and IL-17 concentrations. In conclusion, we completed our objective of characterizing the PCSK9-regulated pathway of bacterial lipid uptake, and provide supporting evidence for targeting PCSK9 as a novel therapeutic avenue in sepsis.
Drug Delivery to the Posterior Segment of the Eye: Challenges and Opportunities (2011)

There is an increasing need for successfully managing the rapidly progressing posterior eye diseases such as age-related macular degeneration, diabetic retinopathy and glaucoma. Therefore the challenges of drug delivery to the posterior eye are compounded by growing number of new therapeutic entities and the need for chronic therapy. Currently, the intravitreal route is widely used to deliver drugs, but frequent administration of drugs via this route can lead to retinal detachment, endophthalmitis and increased intraocular pressure. Controlled delivery systems, such as implants and nanoparticles have been developed to overcome these issues, but they are not devoid of adverse effects. Periocular route is a promising alternative owing to the large surface area and the relatively high permeability of the sclera. Yet, the blood retinal barriers and efflux transporters hamper the transport of therapeutic entities to the retina. As such the efficient delivery of drugs to the posterior eye remains a major challenge facing the pharmaceutical scientist. This review discusses the barriers to posterior eye drug delivery and current strategies used to overcome these barriers. Keywords: Implants, Intravitreal route, Iontophoresis, Microneedles, Posterior eye drug delivery, Transscleral route, Drug Delivery Systems, transscleral routes, transdermal delivery
The p53 Tumor Suppressor Gene: From Molecular Biology to Clinical Investigation (2000)

The tumor suppressor p53 is a phosphoprotein barely detectable in the nucleus of normal cells. Upon cellular stress, particularly that induced by DNA damage, p53 can arrest cell cycle progression, thus allowing the DNA to be repaired; or it can lead to apoptosis. These functions are achieved, in part, by the transactivational properties of p53, which activate a series of genes involved in cell cycle regulation. In cancer cells bearing a mutant p53, this protein is no longer able to control cell proliferation, resulting in inefficient DNA repair and the emergence of genetically unstable cells. The most common changes of p53 in human cancers are point missense mutations within the coding sequences of the gene. Such mutations are found in all major histogenetic groups, including cancers of the colon (60%), stomach (60%), breast (20%), lung (70%), brain (40%), and esophagus (60%). It is estimated that p53 mutations are the most frequent genetic event in human cancers, accounting for more than 50% of cases. One of the most striking features of the inactive mutant p53 protein is its increased stability (half-life of several hours, compared to 20 min for wild-type p53) and its accumulation in the nucleus of neoplastic cells. Therefore, positive immunostaining is indicative of abnormalities of the p53 gene and its product. Several studies have shown that p53 mutations are associated with short survival in colorectal cancer, but the use of p53 as a tumoral marker is still a matter of debate.
Single-Photon Avalanche Diode CMOS Sensor for Time-Resolved Fluorescence Measurements (2009)

A single-photon avalanche diode-based pixel array for the analysis of fluorescence phenomena is presented. Each 180 times 150 - mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> pixel integrates a single photon detector combined with an active quenching circuit and a 17-bit digital events counter. On-chip master logic provides the digital control phases required by the pixel array with a full programmability of the main timing synchronisms. The pixel exhibits an average dark count rate of 3 kcps and a dynamic range of over 120-dB in time uncorrelated operation. A complete characterization of the single photon avalanche diode characteristics is reported. Time-resolved fluorescence measurements have been demonstrated by detecting the fluorescence decay of quantum-dot samples without the aid of any optical filters for excitation laser light cutoff.