gebhart/patrepeval huggingface dataset:
Automated cleaning of wind turbine blades with no downtime (2017)

Several factors affect the power generation efficiency of wind energy extracted from wind turbines. One of them is dust accumulation resulting in roughness of the blade surface and resulting in power loss. To overcome this problem, wind turbine blades need to be cleaned frequently. There are some existing techniques of cleaning but not very efficient and economically viable. In this paper, we have analyzed and discussed, an algorithm for fully automated wind turbine blade cleaning system with no downtime and thereby more economically efficient even over the semi-automated blade cleaning solutions available in literature. The proposed solution also does not use water jets unlike other existing solutions.
Introduction (2003)

This book is based on my experiences of working within, and hands-on building of, innovative teams over the past 20 years. It also draws on the knowledge of executives, consultants and scholars, who have helped me develop and lead high performance innovative teams over those years. It gleans from the successes and indeed the deficiencies in real-world innovation programmes in some of the most competitive environments imaginable.KeywordsSuccessful InnovationTime CompressionTeam BuildingPublic Service SectorBusiness SurvivalThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Production of Recombinant Human Osteoprotegrin from Trichoplusia Ni Cells and Bombyx Mori Larvae (2004)

Human osteoprotegrin (OPG) and its truncated mutant OPG-280 and lengthened mutant OPG-Fc were constructed and successfully expressed in Trichoplusia ni cells and Bombyx mori larvae. Native SDS-PAGE and Western blot analysis revealed that OPG-Fc is present as a homodimer in Tn cells or B. mori larvae compared with OPG and OPG-280. Furthermore, the hypocalcemic effect assay showed that truncation of the C-terminal 100 residues OPG does not abolish the biological activity and Fc can be helpful in forming the OPG homodimer with improved biological activity.
The Response to Long-Term Overfeeding in Identical Twins (1990)

We undertook this study to determine whether there are differences in the responses of different persons to long-term overfeeding and to assess the possibility that genotypes are involved in such differences. After a two-week base-line period, 12 pairs of young adult male monozygotic twins were overfed by 4.2 MJ (1000 kcal) per day, 6 days a week, for a total of 84 days during a 100-day period. The total excess amount each man consumed was 353 MJ (84,000 kcal). During overfeeding, individual changes in body composition and topography of fat deposition varied considerably. The mean weight gain was 8.1 kg, but the range was 4.3 to 13.3 kg. The similarity within each pair in the response to overfeeding was significant (P less than 0.05) with respect to body weight, percentage of fat, fat mass, and estimated subcutaneous fat, with about three times more variance among pairs than within pairs (r approximately 0.5). After adjustment for the gains in fat mass, the within-pair similarity was particularly evident with respect to the changes in regional fat distribution and amount of abdominal visceral fat (P less than 0.01), with about six times as much variance among pairs as within pairs (r approximately 0.7). We conclude that the most likely explanation for the intrapair similarity in the adaptation to long-term overfeeding and for the variations in weight gain and fat distribution among the pairs of twins is that genetic factors are involved. These may govern the tendency to store energy as either fat or lean tissue and the various determinants of the resting expenditure of energy.
miRGen: a database for the study of animal microRNA genomic organization and function (2006)

miRGen is an integrated database of (i) positional relationships between animal miRNAs and genomic annotation sets and (ii) animal miRNA targets according to combinations of widely used target prediction programs. A major goal of the database is the study of the relationship between miRNA genomic organization and miRNA function. This is made possible by three integrated and user friendly interfaces. The Genomics interface allows the user to explore where whole-genome collections of miRNAs are located with respect to UCSC genome browser annotation sets such as Known Genes, Refseq Genes, Genscan predicted genes, CpG islands and pseudogenes. These miRNAs are connected through the Targets interface to their experimentally supported target genes from TarBase, as well as computationally predicted target genes from optimized intersections and unions of several widely used mammalian target prediction programs. Finally, the Clusters interface provides predicted miRNA clusters at any given inter-miRNA distance and provides specific functional information on the targets of miRNAs within each cluster. All of these unique features of miRGen are designed to facilitate investigations into miRNA genomic organization, co-transcription and targeting. miRGen can be freely accessed at http://www.diana.pcbi.upenn.edu/miRGen.
Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA (2016)

Therapeutically targetable driver and resistance mutations can be detected by ctDNA NGS, even when tissue is unavailable, thus allowing more accurate diagnosis, improved patient management, and serial sampling to monitor disease progression and clonal evolution. Clin Cancer Res; 22(23); 5772-82. ©2016 AACR.
Advances in picture coding (1985)

This paper presents a review of the advances in digital coding of video signals during the last four years. Displacement estimation algorithms for coding applications are compared first and the relationship between the algorithms is pointed out. The developments in predictive and transform coding are described and discussed with view to broadcast television and video-conferencing applications. One chapter summarizes the first promising results of motion adaptive frame interpolation. Some problems to be solved in the future are pointed out in the conclusions.
A new Si:C epitaxial channel nMOSFET architecture with improved drivability and short-channel characteristics (2004)

We present for the first time epitaxially grown Si:C nMOSFET channels acting as boron blocking barriers containing up to 1.4% substitutional carbon. The high impact of interstitial carbon and epitaxial growth conditions on electron inversion layer mobility is evidenced for the first time. We achieved super-retrograde channel and pockets profiles for improved short channel effects control. This allows improved I/sub ON/(850 /spl mu/A//spl mu/m)/I/sub OFF/(200 nA//spl mu/m) ratio as compared to non-carbonated short channel devices without any degradation of transport properties or gate oxide integrity.
Backside Illuminated “Ge-on-Si” NIR Camera (2021)

In this paper, a near-infrared “Ge-on-Si” camera with backside illumination, is presented. The camera consists of a photonic chip, a readout chip, and a commercial microcontroller, which is connected to a laptop via USB. The functionality of two-dimensional ( 10×10 pixels) as well as one-dimensional ( 64×1 pixel) “Ge-on-Si” pixel arrays with a pitch of 25 μm are demonstrated. The photonic chip consists of basic CMOS technology process in combination with a molecular beam epitaxy growth process. With this technology and the backside illumination a high fill-factor of 74% is achieved. Further the “Ge-on-Si” detectors are operated under zero bias operation in order to minimize the dark current and thus to maximize the signal-to-noise ratio. This enables dark currents better than 100 pA to be achieved in each pixel. A linear behavior between photocurrent and optical power of the “Ge-on-Si” detectors over a large dynamic range for optical powers between 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> W and 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> W is shown. With relatively thin Ge absorption layers of only 400 nm, optical responsivities of 0.36 A/W at a wavelength of 1310 nm could be achieved. The functionality of the “Ge-on-Si” camera is demonstrated by the movement of a single mode fiber over the photonic chip at a wavelength of 1310 nm.
Allele-Specific Chromosome 3p Deletions Occur at an Early Stage in the Pathogenesis of Lung Carcinoma (1995)

Deletions in the short arm of chromosome 3 occur at the earliest stage (hyperplasia) in the pathogenesis of lung cancer and involve all regions of the respiratory tract. Allele loss is highly specific, but its mechanism remains unknown. Our findings may be of considerable biologic, prognostic, and clinical significance.
CONFIGURATION OF DIHYDROSPHINGOSINE (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCONFIGURATION OF DIHYDROSPHINGOSINEHerbert E. Carter and David ShapiroCite this: J. Am. Chem. Soc. 1953, 75, 20, 5131–5132Publication Date (Print):October 1, 1953Publication History Published online1 May 2002Published inissue 1 October 1953https://pubs.acs.org/doi/10.1021/ja01116a519https://doi.org/10.1021/ja01116a519research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Strategies to determine the extent of control exerted by glucose transport on glycolytic flux in the yeast Saccharomyces bayanus (1999)

The extent to which the transport of glucose across the plasma membrane of the yeast Saccharomyces bayanus controls the glycolytic flux was determined. The magnitude of control was quantified by measuring the effect of small changes in the activity of the glucose transport system on the rate of glucose consumption. Two effectors were used to modulate the activity of glucose transport: (i) maltose, a competitive inhibitor of the glucose transport system in S. bayanus (as well as in Saccharomyces cerevisiae) and (ii) extracellular glucose, the substrate of the glucose transport system. Two approaches were followed to derive from the experimental data the flux control coefficient of glucose transport on the glycolytic flux: (i) direct comparison of the steady-state glycolytic flux with the zero trans-influx of glucose and (ii) comparison of the change in glycolytic flux with the concomitant change in calculated glucose transport activity on variation of the extracellular glucose concentration. Both these approaches demonstrated that in cells of S. bayanus grown on glucose and harvested at the point of glucose exhaustion, a high proportion of the control of the glycolytic flux resides in the transport of glucose across the plasma membrane.
Architecture of SIPS, a real time image processing system (2003)

A real-time image processing system called SIPS (Sight Information Processing System) has been designed and constructed. SIPS realizes a high-speed performance of 2.7 Giga operations/s through parallel and distributed processing of its 82 independently controlled processors. SIPS provides both real-time processing of color video images and a high degree of flexibility. SIPS became operational in 1985 and has been used for research on video image processing such as low-level vision processing and image coding. The architectures and possible applications of SIPS are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Two-dimensional Penrose-tiled photonic quasicrystals: from diffraction pattern to band structure (2000)

We report measurements of the diffraction pattern of a two-dimensional photonic quasicrystal structure and use the set of plane waves defined by the diffraction pattern as the basis of a theoretical approach to calculate the photonic band structure of the system. An important feature of the model is that it retains the essence of the rotational and inflational properties of the quasicrystal at all levels of approximation: properties lost in approximate models which artificially introduce elements of periodicity.&#13;\n&#13;\nThe calculated density of modes of the quasicrystals is found to display a weakly depleted region analogous to the bandgap that occurs in a periodic system. The calculated transmission spectra for different polarizations and directions of propagation show features that correlate with the behaviour of the density of modes.&#13;\n
Experimental surgery to create subgenomes of <i>Bacillus subtilis</i>  168 (1997)

The 4,188-kb circular genome of Bacillus subtilis 168 was artificially dissected into two stable circular chromosomes in vivo, one being the 3,878-kb main genome and the other the 310-kb subgenome that was recovered as covalently closed circular DNA in CsCl-ethidium bromide ultracentrifugation. The minimal requirements to physically separate the 310-kb DNA segment out of the genome were two interrepeat homologous sequences and an origin of DNA replication between them. The subgenome originated from the 1,255-1, 551-kb region of the B. subtilis genome was essential for the cell to survive because the subgenome was not lost from the cell. The finding that the B. subtilis genome has a potential to be divided and the resulting two replicons stably maintained may shed light on origins and formation mechanisms of giant plasmids or second chromosomes present in many bacteria. Similar excision or its reversal process, i.e., integration of large sized covalently closed circular DNA pieces into the main genome, implies significant roles of subgenomes in the exchange of genetic information and size variation of bacterial genomes in bacterial evolution.
Noninvasive detection of airway constriction in awake guinea pigs (1984)

Tidal volume measured by the barometric method is very sensitive to increases in compression and expansion of alveolar gas, such as would be expected to occur during airway narrowing or closure. By comparing a barometric method tidal volume signal (VT') with a reference tidal volume (VT) obtained with a head-out pressure plethysmograph, a simple index related to gas compressibility effects was calculated (VT/VT'). Changes in this index were compared with decreases in dynamic compliance (Cdyn) during histamine aerosol challenge of 15 Charles River Hartley guinea pigs. Decreases in VT/VT' occurred during all aerosol challenges and were correlated with decreases in Cdyn (r = 0.84, P less than 0.001). Decreases in VT/VT' were most marked at Cdyn values of less than 50% of base line. At Cdyn of less than 15% of base line, VT' was 3.1-4.8 times the VT reference signal. No increase in total pulmonary resistance was noted, and Cdyn and VT/VT' returned to base line after histamine exposure was stopped. We conclude that gas compressibility effects become substantial during histamine-induced airway constriction in the guinea pig and that the VT/VT' ratio appears to provide a simple noninvasive method of detecting these changes.
Preferential Image Segmentation Using Trees of Shapes (2009)

A novel preferential image segmentation method is proposed that performs image segmentation and object recognition using mathematical morphologies. The method preferentially segments objects that have intensities and boundaries similar to those of objects in a database of prior images. A tree of shapes is utilized to represent the content distributions in images, and curve matching is applied to compare the boundaries. The algorithm is invariant to contrast change and similarity transformations of translation, rotation and scale. A performance evaluation of the proposed method using a large image dataset is provided. Experimental results show that the proposed approach is promising for applications such as object segmentation and video tracking with cluttered backgrounds.
Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression (2004)

The mal gene which is switched-off in all ESCC samples can be considered as a tumor suppressor gene that more studies in its regulation may lead to valuable explanations in ESCC development. Akr1c2 which is up-regulated in ESCC probably plays an important role in tumor development of esophagus and may be proposed as a potential molecular target in ESCC treatments. Differential display technique in spite of many disadvantages is still a valuable technique in gene function exploration studies to find new candidates for improved ones like gene chips.
Kinetic model of copper electrodeposition in sulfate solution containing trisodium citrate complexing agent (2016)

Simultaneous solution of two kinetic models of electrodeposition of copper in sulfate solution is studied in this paper. Bulk concentration of species involved in the numerical solution was calculated using MATLAB software. COMSOL Multiphysics software was used for the numerical solution of copper electrodeposition. Numerical results were evaluated using experimental data obtained by linear sweep voltammetry technique. The experimental data was almost fitted using COMSOL optimization physic module. It was found that kinetic parameters of Cu2+ (k 1Cu), Cu1+ (k 2Cu), and CuCitH (k 1CuCitH) and diffusion coefficient and charge transfer coefficient of Cu2+ ( $${D_{C{u^{2 + }}}}$$ , αCu1), Cu1+ (αCu2) and CuCitH (D CuCitH, αCuCitH) affect the fitting of the experimental data with the computed ones. The variables such as concentration profiles and optimum kinetic parameters that cannot be experimentally measured were achieved by analysis of the model. The parameters, that not affect the fitting, were recognized and kept constant when using the optimization.
Hyperspectral Imaging with Stimulated Raman Scattering by Chirped Femtosecond Lasers (2012)

Raman microscopy is a quantitative, label-free, and noninvasive optical imaging technique for studying inhomogeneous systems. However, the feebleness of Raman scattering significantly limits the use of Raman microscopy to low time resolutions and primarily static samples. Recent developments in narrowband stimulated Raman scattering (SRS) microscopy have significantly increased the acquisition speed of Raman based label-free imaging by a few orders of magnitude, at the expense of reduced spectroscopic information. On the basis of a spectral focusing approach, we present a fast SRS hyperspectral imaging system using chirped femtosecond lasers to achieve rapid Raman spectra acquisition while retaining the full speed and image quality of narrowband SRS imaging. We demonstrate that quantitative concentration determination of cholesterol in the presence of interfering chemical species can be achieved with sensitivity down to 4 mM. For imaging purposes, hyperspectral imaging data in the C-H stretching region is obtained within a minute. We show that mammalian cell SRS hyperspectral imaging reveals the spatially inhomogeneous distribution of saturated lipids, unsaturated lipids, cholesterol, and protein. The combination of fast spectroscopy and label-free chemical imaging will enable new applications in studying biological systems and material systems.
Inhibition of submandibular and lacrimal gland infiltration in nonobese diabetic mice by transgenic expression of soluble TNF-receptor p55. (1996)

Besides a prominent mononuclear cell infiltration of the islets of Langerhans, nonobese diabetic (NOD) mice also show massive cellular infiltrates of the submandibular and lacrimal glands concomitant with histological signs of tissue damage. To obtain insights into the mechanisms operative during the initiation and progression of tissue damage, we followed by in situ hybridization the appearance of cells containing mRNA of the gene encoding the proinflammatory cytokine TNF-alpha in the cellular infiltrates. Cells expressing TNF-alpha are mainly located in infiltrates, are absent in nonaffected glands, and are preferentially found among CD4 T cells. Secretion of TNF-alpha by gland-infiltrating cells was confirmed by an ELISPOT procedure. Direct evidence for an instrumental role of TNF-alpha in initiation and progression of submandibular and lacrimal gland infiltration is provided by the observed significant reduction in the extent of infiltration in nonobese diabetic mice transgenic for a soluble TNF receptor p55 fused to the Fc part of human IgG3. This protection from infiltration is paralleled by decreased expression of the adhesion molecules ICAM-1 and VCAM-1 in submandibular and lacrimal glands. These data suggest a central role of TNF-alpha in the initiation and progression of autoimmune tissue destruction of salivary glands and indicate beneficial effects of soluble TNF receptors in the treatment of organ-specific autoimmune diseases.
The Effects of Human Serum and Cerebrospinal Fluid on Retroviral Vectors and Packaging Cell Lines (1995)

Human serum is known to inactivate many retroviruses, including murine leukemia viruses (MLV). Exposure of vectors based on MLV to human serum components would presumably decrease the efficiency of gene transfer in vivo. Human serum also lyses xenogeneic cells, which would affect the survival of retroviral vector packaging cells in vivo. The effects of other body fluids, such as cerebrospinal fluid (CSF), on MLV vectors and packaging lines have not been studied. We have found that retroviral vectors packaged in ecotropic, amphotropic, and gibbon ape leukemia virus (GALV) envelope proteins were all inactivated by human sera, and human sera also lysed mouse NIH-3T3 cells and the retroviral vector packaging cells derived from them. Human fibroblasts producing amphotropic vector particles were resistant to lysis, but the particles produced by them were inactivated. In contrast, CSF did not inactivate MLV vectors, nor did it lyse murine retrovirus packaging cells. Our results suggest that exposure to human serum may prevent in vivo gene transfer by MLV vectors and xenogeneic packaging lines, but gene transfer within the central nervous system should be more successful.