gebhart/patrepeval huggingface dataset:
Interleukin-11 Attenuates Nephrotoxic Nephritis in Wistar Kyoto Rats (2001)

Interleukin-11 (IL-11) is a multifuctional cytokine with anti-inflammatory activity. The effect of IL-11 was studied in an experimental model of necrotizing glomerulonephritis induced in Wistar Kyoto rats by an injection of anti-glomerular basement membrane antibody (nephrotoxic serum). Intraperitoneal injection was chosen as the route of IL-11 administration in all experiments. In experiment 1, recombinant human IL-11 (1360 microg) was given 2 h before nephrotoxic serum, then once daily until day 6. In experiment 2, a lower dose of IL-11 (800 microg/d) was used. Rats were treated either with IL-11 400 microg twice daily intraperitoneally or with 800 microg once daily intraperitoneally for 6 d. In experiment 3, the lower dose of IL-11 was given 2 h before nephrotoxic serum, then twice daily until day 2. In experiment 1, IL-11 significantly reduced proteinuria (13.2 +/- 3.3 versus 63.2 +/- 4.3 mg/24 h), fibrinoid necrosis (0.58 +/- 0.08 versus 1.52 +/- 0.06 quadrants/glomerular cross section [gcs]), macrophage infiltration (ED1-positive cells, 24.4 +/- 1.8 versus 39.3 +/- 1.9 cells/gcs), apoptosis (1.11 +/- 0.1 versus 2.39 +/- 0.2 apoptotic bodies/gcs), and proliferating cell nuclear antigen-positive cells (24.4 +/- 2.0 versus 37.3 +/- 2.3 cells/gcs). Inducible nitric oxide synthase-positive cells were significantly increased (3.1 +/- 0.3 versus 2.0 +/- 0.2 cells/gcs). In experiment 2, a lower dose of IL-11 significantly reduced proteinuria and fibrinoid necrosis. Macrophage infiltration was similar in treated and control groups, although the number of sialoadhesin-positive macrophages (ED3+) was significantly reduced in the IL-11-treated rats. In experiment 3, quantitative competitive reverse transcriptase-polymerase chain reaction showed that the mRNA ratio of IL-1 beta/beta-actin in the treated rats was reduced compared with controls. By the use of probes designed from mouse IL-11 receptor alpha-chain sequence, it was also shown that rat mesangial cells and macrophages expressed IL-11 receptor alpha-chain, demonstrating that they were capable of responding to IL-11. In this model of necrotizing glomerulonephritis, high-dose IL-11 treatment markedly reduced both proteinuria and fibrinoid necrosis. At the lower dose, there was a reduction in glomerular injury and macrophage sialoadhesin expression, but without an alteration of macrophage numbers, suggesting that IL-11 may be acting in part to reduce macrophage activation.
Common Abnormalities and Disorder-Specific Compensation During Implicit Regulation of Emotional Processing in Generalized Anxiety and Major Depressive Disorders (2011)

These data support the existence of a common abnormality in anxiety and depression in the ventral cingulate and the amygdala, which may be related to a shared genetic etiology. Compensatory engagement of cognitive control circuitry in depression illustrates how the complex nature of psychopathology arises from the interaction of deficits and compensation, all of which can occur at an implicit level.
Effect of thermal cycling on dimensional stability of Zerodur and ULE (1984)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. J. Shaffer and Harold E. Bennett, "Effect of thermal cycling on dimensional stability of Zerodur and ULE," Appl. Opt. 23, 2852-2853 (1984) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
State of the Art in Burn Treatment (2005)

Optimal treatment of burn victims requires deep understanding of the profound pathophysiological changes occurring locally and systemically after injury. Accurate estimation of burn size and depth, as well as early resuscitation, is essential. Good burn care includes also cleansing, debridement, and prevention of sepsis. Wound healing, is of major importance to the survival and clinical outcome of burn patients. An ideal therapy would not only promote rapid healing but would also act as an antiscarring therapy. The present article is a literature review of the most up-to-date modalities applied to burn treatment without overlooking the numerous controversies that still persist.
Western Analysis of Transgenic Plants (1998)

Western blotting combines the resolving power of protein electrophoresis and the specificity of immunology in a rapid and sensitive format for the identification of proteins in complex mixtures. Proteins resolved by electrophoresis are transferred to a solid support, which is normally nitrocellulose or polyvinylidene fluoride (PVDF [Millipore, Bedford, MA]). Immunological detection of proteins transferred to a solid support combines ease of handling with accessibility of antibodies to the immobilized protein. A primary antibody is bound to a specific antigen on the membrane, and this antibody is detected using a labeled high-affinity reporter (frequently an enzyme-linked antibody). This chapter describes a basic protocol for the Western blotting and detection of transgene expression products in plants (Fig. 1). An alternative procedure for the initial immunopurification and concentration of a transgene product is also described, based on the use of affinity-purified antibodies covalently attached to magnetic beads. Western blotting can be applied to any gel separation technique; however, one-dimensional sodium dodecyl sulfate-poly acrylamide gel electrophoresis (SDS-PAGE) (1,2) is most commonly used.
Neural concurrent subsampling and interpolation for images (2003)

This paper presents a new method for image subsampling and interpolation based on the feedforward neural network (FNN). The proposed technique employs a single FNN with three hidden layers for both subsampling and interpolation, providing the advantages of high speed, parallel processing capability, and good image reproduction quality. Experimental results show that the proposed technique exhibits an increased performance over conventional ones.
A Novel Approach for Mining Association Rules on Sports Data using Principal Component Analysis: For Cricket match perspective (2009)

Sports coaches today have an access to a wide variety of information sources that describe the performance of their players. Cricket match data is highly available and rapidly growing in size which far exceeds the human abilities to analyze. Our major intention is to model an automated framework to identify specifics and correlations among play patterns, so as to haul out knowledge which can further be represented in the form of useful information in relevance to modify or improve coaching strategies and methodologies to confine performance enrichment at team level as well as individual. With this information, a coach can assess the effectiveness of certain coaching decisions and formulate game strategy for subsequent games. Since real time cricket data is too complex , Object-relational model is used to employ more sophisticated structure to store such data. Frequent pattern evaluation is imperative for sports be fond of cricket match data which facilitates recognition of main factors accounting for variances in data. While using simple apriori for interrelationship analysis, it is less time efficient because the raw data set which is too large and complex. On integrating association mining with Principal Component Analysis, the efficiency of mining algorithm is improved provided that Principal Component Analysis generates frequent patterns through statistical analysis and summarization not by repeated searching like other frequent patterns generation techniques. As the size and dimension of annotation database is large, Principal Component Analysis proceeds as a compression mechanism. Then the frequent patterns are analyzed for their interrelationship in order to generate interesting and confident rules of association.
Polymer Microgels:  Reactors for Semiconductor, Metal, and Magnetic Nanoparticles (2004)

We report a strategy for the production of materials with structural hierarchy. The approach employs polymer microgels as templates for the synthesis of semiconductor, metal, or magnetic nanoparticles (NPs). We show that NPs with predetermined dimensions and size-dependent properties can be synthesized by using a very delicate balance between the reaction conditions, the composition and the structure of microgel templates, and the concentration of NPs in the microgel. Postheat treatment of microgels doped with semiconductor nanoparticles reduces NP polydispersity and allows control of their photoluminescence. Microgel templates are particularly beneficial in the synthesis of polymer microspheres heavily loaded with monodisperse superparamagnetic Fe(3)O(4) NPs. Hybrid submicrometer-size microgels have promising potential applications in photonics, catalysis, and separation technologies.
License Plate Recognition From Still Images and Video Sequences: A Survey (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> License plate recognition (LPR) algorithms in images or videos are generally composed of the following three processing steps: 1) extraction of a license plate region; 2) segmentation of the plate characters; and 3) recognition of each character. This task is quite challenging due to the diversity of plate formats and the nonuniform outdoor illumination conditions during image acquisition. Therefore, most approaches work only under restricted conditions such as fixed illumination, limited vehicle speed, designated routes, and stationary backgrounds. Numerous techniques have been developed for LPR in still images or video sequences, and the purpose of this paper is to categorize and assess them. Issues such as processing time, computational power, and recognition rate are also addressed, when available. Finally, this paper offers to researchers a link to a public image database to define a common reference point for LPR algorithmic assessment. </para>
Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood (2003)

Disorders of testicular function may have their origins in fetal or early life as a result of abnormal development or proliferation of Sertoli cells. Failure of Sertoli cells to mature, with consequent inability to express functions capable of supporting spermatogenesis, is a prime example. In a similar way, failure of Sertoli cells to proliferate normally at the appropriate period in life will result in reduced production of spermatozoa in adulthood. This review focuses on the control of proliferation of Sertoli cells and functional maturation, and is motivated by concerns about 'testicular dysgenesis syndrome' in humans, a collection of common disorders (testicular germ-cell cancer, cryptorchidism, hypospadias and low sperm counts) which are hypothesized to have a common origin in fetal life and to reflect abnormal function of Sertoli (and Leydig) cells. The timing of proliferation of Sertoli cells in different species is reviewed, and the factors that govern the conversion of an immature, proliferating Sertoli cell to a mature, non-proliferating cell are discussed. Protein markers of maturity and immaturity of Sertoli cells in various species are reviewed and their usefulness in studies of human testicular pathology are discussed. These markers include anti-Mullerian hormone, aromatase, cytokeratin-18, GATA-1, laminin alpha5, M2A antigen, p27(kip1), sulphated glycoprotein 2, androgen receptor and Wilms' tumour gene. A scheme is presented for characterization of Sertoli-cell only tubules in the adult testis according to whether or not there is inherent failure of maturation of Sertoli cells or in which the Sertoli cells have matured but there is absence, or acquired loss, of germ cells. Functional 'de-differentiation' of Sertoli cells is considered. It is concluded that there is considerable evidence to indicate that disorders of maturation of Sertoli cells may be a common underlying cause of human male reproductive disorders that manifest at various life stages. This recognition emphasizes the important role that animal models must play to enable identification of the mechanisms via which failure of proliferation and maturation of Sertoli cells can arise, as this failure probably occurs in fetal life.
Communicating between Cells (2004)

This chapter contains sections titled: Neuro-Immuno-Endocrinology Plant Signaling Arthropod Hormones Vertebrate Endocrine System Conclusion
Differentiation of the Isomeric <i>o</i>-(<i>m</i>- and <i>p</i>-) Nitro-(Chloro- and Bromo-)Benzyl-2,4-(and 2,1-) Disubstituted 2-Thiocytosinium Halides by Electron Impact Ionisation and Fast Atom Bombardment Mass Spectrometry (2009)

Electron ionisation (EI) and fast atom bombardment (FAB) mass spectral fragmentations of nine 2,4-(and 2,1-) disubstituted o-(m- and p-)nitro-(chloro- and bromo-)-2-thiocytosinium halides are investigated. Fragmentation pathways, whose elucidation is assisted by accurate mass measurements and metastable transitions [EI-mass spectrometry (MS)], as well as FAB/collision-induced dissociation (CID) mass spectra measurements are discussed. The correlations between the abundances of the (C(11)H(10)N(4)SO(2))(+) 1-3; (C(11)H(10)N(3)SCl)(+) 4-6 and (C(11)H(10)N(3)SBr)(+) 7-9 ions and the selected fragment ions (EI- MS), as well as (C(18)H(16)N(5)SO(4))(+) 1-3; (C(18)H(16)N(3)SCl(2))(+) 4-6 and (C(18)H(16)N(3)SBr(2))(+) 7-9 ions and the selected ions (C(7)H(6)NO(2))(+) 1-3; (C(7)H(6)Cl)(+) 4-6; (C(7)H(6)Br)(+) 7-9 (FAB-MS) are discussed. The data obtained can be used for distinguishing isomers.
Quantitative semi-micro hemagglutination. A sensitive assay dependent upon cellular dissociation and migration in capillary tubes. (1966)

Summary A relatively inexpensive procedure for the quantitative assay of serum agglutinins is proposed. It offers simplicity and convenience in operation and sensitivity and reproducibility in results. The technique is based on the migration of cells down the inclined trough of a sealed micro-hematocrit tube. This system appears to depend upon the rate of cellular detachment from a centrifuged pellet by the dissociative force of gravity.
Design methodology and synthesis techniques for ladder-type SAW resonator coupled filters (1993)

New types of SAW filter called “extended SAW resonator coupled filter” have been developed for 800-MHz and 0.6 to 1.0 W cellular-radio pocket phones. They have not only high-performance and high-power characteristics but also very small 3rd-order nonlinearities. We investigated a new equivalent circuit for IDTs with leaky SAWs. This circuit includes propagation losses due to leakage and conductance caused by bulkwave radiation. Design and synthesis procedures for the new SAW filters based on new treatments of leaky SAWs are discussed. Simulation and experimental results are also given for the frequency characteristics of the filters used in an antenna duplexer of USA cellular radio
Imaging of branched chain amino acid metabolism in tumors with hyperpolarized <sup>13</sup>C ketoisocaproate (2009)

Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employed to quickly collect detailed spectral information on the chemical fate of tracer molecules in different tissues at high sensitivity. Here, we report a preclinical study showing that alpha-ketoisocaproic acid (KIC) can be used to assess molecular signatures of tumors with hyperpolarized MR spectroscopy. KIC is metabolized to leucine by the enzyme branched chain amino acid transferase (BCAT), which is found upregulated in some tumors. BCAT is a putative marker for metastasis and a target of the proto-oncogene c-myc. Very different fluxes through the BCAT-catalyzed reaction can be detected for murine lymphoma (EL4) and rat mammary adenocarcinoma (R3230AC) tumors in vivo. EL4 tumors show a more than 7-fold higher hyperpolarized (13)C leucine signal relative to the surrounding healthy tissue. In R3230AC tumor on the other hand branched chain amino acid metabolism is not enhanced relative to surrounding tissues. The distinct molecular signatures of branched chain amino acid metabolism in EL4 and R3230AC tumors correlate well with ex vivo assays of BCAT activity.
Ischemia/reperfusion-induced microvascular dysfunction: role of oxidants and lipid mediators (1997)

The objective of this study was to define the role of oxidants and lipid mediators in the leukocyte-endothelial cell adhesion and albumin leakage elicited in rat mesenteric venules by ischemia-reperfusion (I/R). Intravital fluorescence microscopy was used to monitor leukocyte adherence and emigration, platelet-leukocyte aggregation, mast cell degranulation, and albumin leakage after release of a 20-min arterial occlusion. I/R elicited large increases in leukocyte-endothelial cell adhesion and albumin leakage. These responses were significantly attenuated in venules treated with either superoxide dismutase, oxypurinol (an inhibitor of xanthine oxidase), lodoxamide (a mast cell stabilizer), WEB-2086 (a platelet-activating factor antagonist), or SC-41930 (a leukotriene B4-receptor antagonist) but not by U-74006F (an inhibitor of lipid peroxidation). Platelet-leukocyte aggregates and mast cell degranulation induced by I/R were also attenuated by administration of either superoxide dismutase or lodoxamide. These results support the hypothesis that oxidants produced, in part, by xanthine oxidase promote the formation (by mast cells and endothelial cells) of platelet-activating factor and leukotriene B4, which recruit and activate leukocytes in postischemic venules. The adherent and emigrated leukocytes then mediate the increased albumin extravasation observed in the postcapillary venules.
A piecewise regression analysis with automatic change-point detection (1999)

Most of the conventional regression methods can only estimate a piecewise polynomial function in which the exact positions or the probabilistic distribution of the change-points is prespecified. This paper proposes an optimization method to estimate a piecewise polynomial function with unknown change-points. We first express a piecewise function by the addition of some absolute terms. Utilizing the properties of this function, a piecewise regression model is then formulated to minimize the estimation errors subjected to an amount of change-points. The model is then solved by a modified goal programming technique, which is more computationally efficient than conventional goal programs. Numerical examples demonstrate that the proposed method is very promising in estimating the piecewise regression with automatic change-point detection.
Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin (1992)

The present study demonstrated that nitric oxide, which is an important mammalian metabolite, can inhibit oxidation by lipoxygenase, cyclooxygenase and hemoglobin. The inhibition is manifested as a lag-phase that is reversible. The inhibitory effect of nitric oxide on lipoxygenase and cyclooxygenase seems to derive from i) the capability of .NO to reduce the ferric enzyme to the ferrous form, which is inactive; ii) competition for the iron site available for exogenous ligands; and iii) the radical scavenging ability of the nitroxide radical. Nitric oxide may act as a modulator of the arachidonic acid cascade and in the generation of oxygen-active species.
Immunosuppressive activity of 2'-(3-dimethylaminopropylthio)cinnamanilide (cinanserin) and related compounds. IV (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImmunosuppressive activity of 2'-(3-dimethylaminopropylthio)cinnamanilide (cinanserin) and related compounds. IVJohn Krapcho, Robert C. Millonig, Chester F. Turk, and Blanche J. AmreinCite this: J. Med. Chem. 1969, 12, 1, 164–166Publication Date (Print):January 1, 1969Publication History Published online1 May 2002Published inissue 1 January 1969https://pubs.acs.org/doi/10.1021/jm00301a044https://doi.org/10.1021/jm00301a044research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Histochemical and Electron Microscopic Study on the Nerve Cells of the Pineal Body of Catfish, Parasilurus asotus (1995)

This study was carried out to clarify the neuronal organization in pineal body of catfish. The pineal body was observed by acetylcholinesterase histochemistry and electron microscopy. The neuronal types observed in the pineal body of catfish were bipolar and multipolar cells. Multipolar cells were found throughout the pineal end vesicle and whole stalk, but bipolar cells only in the end vesicle and distal stalk. The pineal tract was formed by the long axons of these neurons. The neuronal clusters(pineal ganglia) were also observed in the end vesicle. In summary, the type of neurons in catfish pineal was different from that of other species, and the neuronal distribution differed depending on the region of pineal body. These results reflect the interspecific and regional differences of the pineal organization of fishes.
Online STATCOM load estimation using inverter synchronized sampler and recursive least-squares (2011)

In this paper, a state-space model of the power system is estimated as seen from the inverter using recursive least-squares (RLS). The inverter may function as a Static Synchronous Compensator (STATCOM), or connecting distributed energy sources to the grid. By using inverter synchronized sampling, measurement noise due to switching glitch are avoided. The method is well suited for online implementation in control design or smart grid applications. The method is verified by simulations and experiments using the estimated system as a one step predictor.
Posttraumatic Complications and Inflammatory Mediators (1986)

In a series of 71 patients with trauma, we measured weekly the blood levels of a number of complement proteins and activation products. We also measured the following: leukocytes, platelets, granulocyte enzyme elastase, alpha 1-antitrypsin, total protein, albumin, haptoglobin, and fibronectin. The intensity of complement activation and the blood levels of elastase correlated with the following factors: injury severity (especially the severity of limb injury), development of adult respiratory distress syndrome, development and severity of multiple organ failure, and probability of a fatal outcome. The plasma elastase level seemed to be the best predictor of adult respiratory distress syndrome and the best correlate of injury severity and multiple organ failure severity. Our findings support the hypothesis that posttraumatic activation of the complement system leads to activation of granulocytes, followed by microvascular injury and finally by organ failure.