gebhart/patrepeval huggingface dataset:
At the heart of the ventral attention system: The right anterior insula (2008)

The anterior insula has been hypothesized to provide a link between attention-related problem solving and salience systems during the coordination and evaluation of task performance. Here, we test the hypothesis that the anterior insula/medial frontal operculum (aI/fO) provides linkage across systems supporting task demands and attention systems by examining the patterns of functional connectivity during word recognition and spatial attention functional imaging tasks. A shared set of frontal regions (right aI/fO, right dorsolateral prefrontal cortex, bilateral anterior cingulate) were engaged, regardless of perceptual domain (auditory or visual) or mode of response (word production or button press). We present novel evidence that: (1) the right aI/fO is functionally connected with other frontal regions implicated in executive function and not just brain regions responsive to stimulus salience; and (2) that the aI/fO, but not the ACC, exhibits significantly correlated activity with other brain regions specifically engaged by tasks with varying perceptual and behavioral demands. These results support the hypothesis that the right aI/fO aids in the coordination and evaluation of task performance across behavioral tasks with varying perceptual and response demands.
THE INHIBITION OF MALIGNANT CELL GROWTH BY KETONE BODIES (1979)

The effect of ketone bodies on the growth, in culture, of transformed lymphoblasts (Raji cells) was investigated. Cell growth was inhibited and this effect was reversible, non-toxic, and proportional to the concentration of D-beta-hydroxybutyrate up to 20mM. The total glucose utilisation and the total lactate production were reduced in proportion to the inhibition of cell proliferation. D-beta-hydroxybutyrate was not metabolised by the cells. Other glycolytic inhibitors and chemical analogues of D-beta-hydroxybutyrate either did not inhibit or proved to be too toxic for cell growth. D-beta-hydroxybutyrate also inhibited the growth of rabbit kidney (RK13), HeLa, mouse melanoma (B16), fibroblast and trypsin-dispersed human thyroid and beef testis cells. Moreover, in vivo dietary-induced ketosis reduced the number of B16 melanoma deposits in the lungs of C57BL/6 mice by two-thirds. The significance of these results in the clinical management of cancer cachexia is discussed.
Dopants and Defects in Semiconductors (2012)

Dopants and Defects in Semiconductors covers the theory, experimentation, and identification of impurities, dopants, and intrinsic defects in semiconductors. The book fills a crucial gap between solid-state physics and more specialized course texts.The authors first present introductory concepts, including basic semiconductor theory, defect classif
Architectural and compiler techniques for energy reduction in high-performance microprocessors (2000)

In this paper, we focus on low-power design techniques for high-performance processors at the architectural and compiler levels. We focus mainly on developing methods for reducing the energy dissipated in the on-chip caches. Energy dissipated in caches represents a substantial portion in the energy budget of today's processors. Extrapolating current trends, this portion is likely to increase in the near future, since the devices devoted to the caches occupy an increasingly larger percentage of the total area of the chip. We propose a method that uses an additional minicache located between the I-Cache and the central processing unit (CPU) core and buffers instructions that are nested within loops and are continuously otherwise fetched from the I-Cache. This mechanism is combined with code modifications, through the compiler, that greatly simplify the required hardware, eliminate unnecessary instruction fetching, and consequently reduce signal switching activity and the dissipated energy. We show that the additional cache, dubbed L-Cache, is much smaller and simpler than the I-Cache when the compiler assumes the role of allocating instructions to it. Through simulation, we show that for the SPECfp95 benchmarks, the I-Cache remains disabled most of the time, and the "cheaper" extra cache is used instead. We also propose different techniques that are better adapted to nonnumeric nonloop-intensive code.
A dose distribution evaluation technique using the k‐d tree for nearest neighbor searching (2010)

Comparing with other algorithms such as exhaustive search and sorted list O (N), the k-d tree algorithm for gamma evaluation is much more efficient.
Diagrammes de puissance conformes pour l'ingénierie de réservoir (2005)

Cet article présente une nouvelle approche de type frontale permettant de générer un maillage hybride 3D en simulation de réservoirs pétroliers. Le maillage épouse les directions des écoulements aux abords des puits et permet d'atteindre une meilleure précision dans les calculs numériques. On insère dans le maillage structuré hexaédrique du réservoir un maillage local, radial et structuré autour de chaque puits. Des maillages déstructurés polyédriques, fondés sur les diagrammes de puissance, assurent la transition entre les maillages structurés.
Renatured Chitin Fibrils, Films, and Filaments (1975)

A method has been developed for the solution and subsequent precipitation of chitin that renatures it in highly ordered, crystalline form closely similar to native chitin. Critical factors include the use of a high molecular weight, soluble chitin and an anhydrous precipitation and neutralization system. A mixture of chloral hydrate, trichloroacetic acid and methylene chloride is an effective solvent, although some solvent residue is retained by the chitin. Acetone is preferred for renaturing. Filaments and films with a good degree of order and crystallinity can be cold drawn to more than double their original length to enhance their properties; tough, pliable films and high strength filaments have been prepared in this way.
Relation of implicit theories to the construction of personal histories. (1989)

It is hypothesized that people possess implicit theories regarding the inherent consistency of their attributes, as well as a set of principles concerning the conditions that are likely to promote personal change or stability. The nature of these theories is discussed in the context of a study of beliefs about life-span development. It is then suggested that people use their implicit theories of self to construct their personal histories. This formulation is used to interpret the results of a wide-ranging set of studies of memory of personal attributes. It is concluded that implicit theories of stability and change can lead to biases in recall. The extent and practical implications of these biases are discussed. Personal memories play an important role in people's everyday lives. Individuals dwell on their pasts for a variety of reasons including entertainment (for others' amusement, people fashion stories out of their lives), curiosity (gazing at their teenage children, parents might wonder what they, themselves, were like as teenagers), and the need to achieve self-understanding. People can study the past to learn about their preferences, abilities, and so forth. Personal recollections are also used to control and manipulate public images. Published autobiographies have served this function for hundreds of years (Korda, 1987). In short, people's personal memories are relevant to some of the traditional concerns of social psychologists, including selfunderstanding and self-presentation. Furthermore, much psychological research depends on personal recall. For example, not so long ago, psychologists formulated theories of development on the basis of parents' retrospective descriptions of their child-rearing practices. We now know that such descriptions may be invalid, and seek more direct evidence (Yarrow, Campbell, & Burton, 1970). Nonetheless, researchers and practitioners continue to make considerable use of retrospective self-reports. These include reports of voting, medical care, purchases, and finances. On the basis of such self-reports, social scientists evaluate theories of human behavior and offer advice on public policy. For a number of reasons, then, it is important to know how personal memories are formed and how accurate they maybe. In 1972, Tulving proposed what has become a widely accepted distinction between episodic and semantic memory. Episodic memory contains information that is coded both temporally and with reference to the rememberer, semantic memory stores general world knowledge that carries neither temporal nor autobiographical codes. In the present article, I examine a
Transient effects in saturated Raman amplifiers (2001)

Transient phenomena in Raman optical amplifiers are studied. For the first time, transient effects are observed in saturated Raman amplifiers. An accurate model is developed to explain these transient effects.
Pseudocapacitive Behavior of Carbon Nanoparticles Modified by Phosphomolybdic Acid (2009)

Chemically modified carbon nanomaterials, such as nanodiamond (ND) soot, onionlike carbon (OLC), and carbon nanotubes (CNTs), were investigated as electrodes for electrochemical capacitors in high rate applications, that is, applications that drain power very fast. A layer of Keggin-type polyphosphomolybdate was coated on carbons through "layer-by-layer" deposition by alternating electrostatic adsorption of cationic [i.e., poly(diallyldimethylammonium)chloride] and anionic (i.e., ) species to add pseudocapacitance to improve current response and increase capacitance. This modification was successful on OLCs and CNTs but not on ND soot. This difference is due to variations in surface chemistry, structure, and content of those materials. In particular, the modified OLC exhibited a 20% increase in capacitance with up to capacitance at 5 V/s, illustrating its high rate capability.
Rapid Response of Emotional Incontinence to Selective Serotonin Reuptake Inhibitors (1998)

Emotional incontinence (EI) is a perturbing condition characterized by uncontrollable outbursts of exaggerated, involuntary facial expressions and pathological crying or laughter. There is increasing evidence that serotonergic neurotransmission may be damaged in EI. The authors report 4 pathological crying cases (3 poststroke and 1 with multiple sclerosis) and 1 case of pathological laughter after traumatic brain injury. EI improved dramatically with three different selective serotonin reuptake inhibitors (fluoxetine, sertraline, and paroxetine) in the context of these different CNS diseases.
Synthesis of(±)-Parasorbic Acid and (±)-Massoilactone from Meldrum's Acid (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of(±)-Parasorbic Acid and (±)-Massoilactone from Meldrum's AcidRobert Stevenson and James V. WeberCite this: J. Nat. Prod. 1988, 51, 6, 1215–1219Publication Date (Print):November 1, 1988Publication History Published online1 July 2004Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/np50060a026https://doi.org/10.1021/np50060a026research-articleACS PublicationsRequest reuse permissionsArticle Views418Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Advances in Red VCSEL Technology (2012)

Red VCSELs offer the benefits of improved performance and lower power consumption for medical and industrial sensing, faster printing and scanning, and lower cost, higher speed interconnects based upon plastic optical fiber (POF). However, materials challenges make it more difficult to achieve the desired performance than at the well-developed wavelength of 850 nm. This paper will describe the state of the art of red VCSEL performance and the results of development efforts to achieve improved output power and a broader temperature range of operation. It will also provide examples of the applications of red VCSELs and the benefits they offer. In addition, the packaging flexibility offered by VCSELs, and some examples of non-Hermetic package demonstrations will be discussed. Some of the red VCSEL performance demonstrations include output power of 14 mW CW at room temperature, a record maximum temperature of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mrow><mml:mn>115</mml:mn></mml:mrow><mml:mo>∘</mml:mo></mml:msup></mml:mrow></mml:math>C for CW operation at an emission wavelength of 689 nm, time to 1% failure at room temperature of approximately 200,000 hours, lifetime in a <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mrow><mml:mn>50</mml:mn></mml:mrow><mml:mo>∘</mml:mo></mml:msup></mml:mrow></mml:math>C, 85% humidity environment in excess of 3500 hours, digital data rate of 3 Gbps, and peak pulsed array power of greater than 100 mW.
Isolation and Characterization of a Differentiation-Dependent Gene in the Human Colonic Cell Line HT29-18 (1993)

The human colonic epithelial cell line HT29, and its clonal derivatives HT29-18 and HT-29-18-C1, differentiate in vitro. Differential screening of a subtraction cDNA library enriched for sequences unique to HT29-18-C1, a highly differentiated subclone of HT29-18, resulted in the isolation of a differentiation-dependent cDNA clone, A4. A full-length clone encoding A4 was obtained and sequenced to its entirety. It is 945 bp in length and contains an open reading frame (ORF) of 456 bp. The amino acid sequence deduced from the ORF reveals a polypeptide of 152 amino acids with a predicted molecular mass of 17,000 Da, a size confirmed by coupled in vitro transcription and translation directed by the full-length A4 cDNA. This polypeptide contains four potential membrane-spanning domains and consensus sequences for N-linked glycosylation as well as phosphorylation sites for protein kinase C and casein kinase II. Comparison of A4 to published DNA and protein sequences revealed no significant homology. Genomic Southern blot analysis suggests that the gene is present in a single copy within the human genome and is conserved in the rat. Northern blot analysis of RNA obtained from various rat tissues shows that the expression of the A4 gene is tissue-selective and is enriched in colonic mucosa. In situ hybridization using human intestinal tissues indicates that the expression of A4 follows a gradient along the crypt-to-villus axis with the most abundant message occurring in the lower half of the crypt. Furthermore, nuclear run-on assays suggest that the induction of the A4 gene during differentiation of HT29-18 is regulated at a transcriptional level. A clone was isolated from a human genomic library and found to contain all five exons of A4. S1 nuclease analysis localized the start site of transcription to an adenosine residue 91 nucleotides upstream from the ATG translation initiation codon. Examination of the immediate sequence 5' to the mRNA start site reveals no TATA box and multiple known enhancer sequences. A4 is also noted to share certain features with the gene encoding the cystic fibrosis transmembrane conductance regulator protein. They include a similar vertical distribution of expression along the intestinal epithelium, enhanced transcription upon differentiation of HT29-18, and multiple shared putative regulatory sequences in the promoter regions. Further characterization of the mechanisms regulating expression of the A4 gene could contribute to the understanding of mammalian intestinal differentiation.
Cloning and Nucleotide Sequence Determination of the Entire <i>mec</i> DNA of Pre-Methicillin-Resistant <i>Staphylococcus aureus</i> N315 (1999)

In methicillin-resistant Staphylococcus aureus, the methicillin resistance gene mecA is localized within a large chromosomal region which is absent in the methicillin-susceptible S. aureus chromosome. The region, designated mec DNA, is speculated to have originated from the genome of another bacterial species and become integrated into the chromosome of the S. aureus cell in the past. We report here cloning and determination of the structure of the entire mec DNA sequence from a Japanese S. aureus strain, N315. The mec DNA was found to be 51,669 bp long, including terminal inverted repeats of 27 bp and a characteristic pair of direct repeat sequences of 15 bp each: one is situated in the right extremity of mec DNA, and the other is situated outside the mec DNA and abuts the left boundary of mec DNA. The integration site of mec DNA was found to be located in an open reading frame (ORF) of unknown function, designated orfX. Clusters of antibiotic resistance genes were noted in mec DNA carried by transposon Tn554 and an integrated copy of plasmid pUB110. Both the transposon and plasmid were integrated in the proximity of the mecA gene, the latter being flanked by a pair of insertion sequence IS431 elements. Many ORFs other than those encoding antibiotic resistance were considered nonfunctional because of the acquired mutations or partial deletions found in the ORFs. Two ORFs potentially encoding novel site-specific recombinases were found in mec DNA. However, there was no ORF that might encode mec DNA-specific transposase or integrase proteins, indicating that the mec DNA is not a transposon or a bacteriophage in nature.
2.488 Gb/s silicon bipolar clock and data recovery IC for SONET (OC-48) (2002)

A Si bipolar IC recovers the clock and retimes the data at 2.488 GHz, while meeting all specifications for SONET (Synchronous Optical Network) OC-48 (optical carrier at 48 times base frequency). This is the first single chip, low power, fully integrated solution in the market. Previous ICs have either required external components or have not been fully compliant with all the specifications. The IC incorporates a voltage controlled oscillator (VCO) with delay tuning that uses integrated spiral inductors. The lock range is broad enough to hold up against process, power supply and temperature variations.
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins (2004)

Cytolytic pore-forming toxins are important for the virulence of many disease-causing bacteria. How target cells molecularly respond to these toxins and whether or not they can mount a defense are poorly understood. By using microarrays, we demonstrate that the nematode Caenorhabditis elegans responds robustly to Cry5B, a member of the pore-forming Crystal toxin family made by Bacillus thuringiensis. This genomic response is distinct from that seen with a different stressor, the heavy metal cadmium. A p38 mitogen-activated protein kinase (MAPK) kinase and a c-Jun N-terminal-like MAPK are both transcriptionally up-regulated by Cry5B. Moreover, both MAPK pathways are functionally important because elimination of either leads to animals that are (i) hypersensitive to a low, chronic dose of toxin and (ii) hypersensitive to a high, brief dose of toxin such that the animal might naturally encounter in the wild. These results extend to mammalian cells because inhibition of p38 results in the hypersensitivity of baby hamster kidney cells to aerolysin, a pore-forming toxin that targets humans. Furthermore, we identify two downstream transcriptional targets of the p38 MAPK pathway, ttm-1 and ttm-2, that are required for defense against Cry5B. Our data demonstrate that cells defend against pore-forming toxins by means of conserved MAPK pathways.
Vertically Unstable Pelvic Fractures Fixed with Percutaneous Iliosacral Screws: Does Posterior Injury Pattern Predict Fixation Failure? (2003)

Percutaneous iliosacral screw fixation is a useful technique in the management of vertically unstable pelvic fractures, but a vertical sacral fracture should make the surgeon more wary of fixation failure and loss of reduction.
Fingerprinting of signal transduction pathways using a combination of anti-phosphotyrosine immunoprecipitations and two-dimensional polyacrylamide gel electrophoresis (2001)

Virtually all known cellular processes involve modulation of cellular signaling pathways via changes in protein phosphorylation. With genomics efforts more than doubling the number of proteins available for analysis, a major challenge will be to identify unknown phosphoproteins as they exist in the normal or diseased intracellular environment. Recent advances in proteomic technology have made it possible to examine changes in protein expression with much greater resolution than was previously possible. In this report, we describe a rapid and reproducible method for identifying phosphoproteins upregulated in response to activation of cell surface receptors. Phosphotyrosine-containing proteins were immunoprecipitated from IFNalpha- or IL2-treated primary human lymphocyte extracts using a novel anti-phosphotyrosine immunoprecipitation technique. This technique takes advantage of differing antibody affinities for epitopes on native versus denatured proteins. Following separation from the immunopellets, phosphoproteins are resolved by two-dimensional polyacrylamide gel electrophoresis. With this method, we identified known proteins phosphorylated in response to IL2 or IFNalpha using both silver staining and Western blotting for protein detection/identification. The silver-stained immunoprecipitation profile serves as a fingerprint for phosphorylation events that occur in response to cytokine treatment. By merging these techniques with mass spectrometric microsequencing, new capabilities are achieved. It will then be possible to identify novel signaling proteins that are activated in response to a variety of stimuli, including receptor activation, disease progression, etc.
Synthesis and Conformational Studies of Dipeptides Constrained by Disubstituted 3-(Aminoethoxy)propionic Acid Linkers (2004)

A series of cyclic compounds with dimethyl-substituted 3-(aminoethoxy)propionic acid linkers have been prepared as potential beta-turn mimics. The desired linkers were prepared from disubstituted pyrones, which were coupled with dipeptides and then subjected to macrocyclization using diethylcyanophosphonate to furnish cyclic compounds 1-5. Conformational analysis was carried out using NMR and X-ray crystallography. All of the five cyclic compounds were found to exist in type I or type II beta-turn conformations.
ChemInform Abstract: An Efficient Solid‐Phase Method for the Preparation of Diaryl Carbazones. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.