gebhart/patrepeval huggingface dataset:
Toward semantic understanding: an approach based on information extraction ontologies (2004)

Information is ubiquitous, and we are flooded with more than we can process. Somehow, we must rely less on visual processing, point-and-click navigation, and manual decision making and more on computer sifting and organization of information and automated negotiation and decision making. A resolution of these problems requires software with semantic understanding—a grand challenge of our time. More particularly, we must solve problems of automated interoperability, integration, and knowledge sharing, and we must build information agents and process agents that we can trust to give us the information we want and need and to negotiate on our behalf in harmony with our beliefs and goals. This paper proffers the use of informationextraction ontologies as an approach that may lead to semantic understanding.
Acrylic polymer-silk fibroin blend fibers (1997)

Blends of acrylic polymer (containing acrylonitrile 91.7%, methyl acrylate 7%, and sodium methyl propenyl sulfonate 1.3% [wt %], denoted as PAC) with silk fibroin (SF) were studied in the form of drawn fibers with varied compositions. The strength, elongation, and specific work of rupture of the blend fibers decrease with increase of the SF content, whereas the modulus has a slight increase up to 20% (wt) SF and then decreases. With the addition of up to 30% (wt %) SF in the PAC matrix, the moisture absorption increases from 2.06 to 6.2% in comparison with the PAC. Scanning electron microscopy studies show that the blend fibers have a sheath–core structure, with SF mainly in the sheath and PAC in the core. FTIR, ATR, and X-ray diffraction results of the blend fibers are also presented. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 65:959–966, 1997
Tapered transducers-design and applications (2002)

The tapered transducer was first demonstrated over 25 years ago but until recently has seen little commercial use. This paper reviews the theory that describes how the wideband response of a tapered transducer is achieved by the summation of narrow-band channels. In addition, it discusses weighting techniques appropriate to tapered transducers including block weighting, and how the use of SPUDT electrode structures allows the same reduction in IL and triple-transit over a wide bandwidth normally achieved only with relatively narrow-band filters. Experimental results are presented along with a discussion of applications that benefit from the unique properties of tapered transducers such as a single-bounce dispersive delay line, a multi-tap delay line with low spurious reflections, a channelizer or filter bank, an AO Bragg cell, and a radar pulse compression system without range/velocity ambiguity in the presence of Doppler.
Simple Summaries for Hashing With Choices (2008)

In a multiple-choice hashing scheme, each item is stored in one of d ges 2 possible hash table buckets. The availability of these multiple choices allows for a substantial reduction in the maximum load of the buckets. However, a lookup may now require examining each of the locations. For applications where this cost is undesirable, Song propose keeping a summary that allows one to determine which of the locations is appropriate for each item, where the summary may allow false positives for items not in hash table. We propose alternative, simple constructions of such summaries that use less space for both the summary and the underlying hash table. Moreover, our constructions are easily analyzable and tunable.
Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859] (1989)

Addition of EGF to human epidermoid carcinoma A431 cells increases the rate of fluid-phase pinocytosis 6-10-fold as measured by horseradish peroxidase uptake (Haigler, H.T., J. A. McKanna, and S. Cohen. 1979. J. Cell Biol. 83:82-90). We show here that in the absence of extracellular Na+ or in the presence of amiloride the stimulation of pinocytosis by EGF is substantially reduced. Amiloride had no effect on the endocytosis of EGF itself or of transferrin, demonstrating that the receptor-mediated endocytotic pathway operated normally under conditions that blocked stimulated pinocytosis. Amiloride blocked EGF-stimulated pinocytosis in both HCO3(-)-containing and HCO3(-)-free media. The EGF-stimulated pinocytotic activity can frequently be localized to areas of the cell where membrane spreading and ruffling are taking place. These results demonstrate that (a) EGF induces a distinct amiloride-sensitive endocytotic pathway on A431 cells; (b) occupied EGF receptors do not utilize this pathway for their own entry; (c) endocytosis of occupied EGF receptors is not in itself sufficient to stimulate pinocytosis.
A new method for the fabrication of submicron thick gallium arsenide membranes (1983)

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NblC, a novel component required for pigment degradation during starvation in <i>Synechococcus</i> PCC 7942 (2005)

Adjustment of photosynthetic light harvesting to ambient conditions is essential to allow efficient energy capturing and to prevent surplus excitation and the cellular damage resulting from it. Degradation of the cyanobacterial light harvesting complex, the phycobilisome, is a general acclimation response occurring under various stress conditions. This study identifies a novel component, NblC, which mediates phycobilisome degradation under nitrogen, sulphur and phosphorus starvation. Our study indicates the requirement of NblC for efficient expression of nblA, an essential component of the degradation pathway; accumulation of nblA transcripts upon nutrient starvation was impaired in the NblC-mutant. Furthermore, expression of NblC under the control of a foreign promoter resulted in accumulation of nblA transcripts and degradation of the light harvesting complex. Transcription of nblC is induced upon nutrient starvation, suggesting the requirement of elevated levels of NblC under these conditions. Importantly, NblC could not exert its positive effect on nblA expression in the absence of the response regulator NblR. Sequence alignment suggests kinase motifs as well as homology of NblC to anti-sigma factors. Accordingly, we suggest a mode of action for this newly identified modulator, which provides new insights into regulation of gene expression in response to environmental stimuli.
Stroma-dependent Maintenance of Cytokine Responsive Hematopoietic Progenitor Cells Derived from Long-term Bone Marrow Culture. (2000)

Hematopoietic cells maintained for long periods on primary cultures of bone marrow stromal cells formed cobblestone colonies (Dexter's long-term bone marrow culture, LTBC). These stably maintained hematopoietic cells (for 4 months) were transferred to a coculture on an established spleen stromal cell line (MSS62), and maintained under stromal cell layer, where they retained their invasive ability in the restricted space between the stromal cell layer and culture substratum (DFC culture). DFC contained lineage-negative (Lin-), c-Kit+, Sca-1- cells and spontaneously produced Mac-1+, Gr-1+ cells. DFC could not grow in the absence of MSS62 stromal cells, although, GM-CSF, IL-3, or IL-7 stimulated its growth. Production of granulocyte and monocytic cells was maintained by GM-CSF or IL-3 while it was decreased by IL-7. RT-PCR analysis showed that the IL-7 responsive cell population expressed early lymphoid markers (Ikaros, Pax-5, Oct-2, Rag-1, TdT, IL-7R and Imu), while lacking expression of receptors for G-CSF (G-CSFR) and for M-CSF (M-CSFR), or myeloperoxidase (MPO). These results suggested that DFC simultaneously contained lymphoid-committed progenitors and myeloid-committed progenitors, and that cytokines may expand their responding progenitor cells under the influence of signals provided by the stromal cells. Such a stromal cell-dependent culture system may be useful to analyze the switching mechanism from constitutive to inducible hematopoiesis in vitro.
Characterization of Y-Ba-Cu-O thin films and yttria-stabilized zirconia intermediate layers on metal alloys grown by pulsed laser deposition (1991)

The use of an intermediate layer is necessary for the growth of YBaCuO thin films on polycrystalline metallic alloys for tape conductor applications. A pulsed laser deposition process to grow controlled-orientation yttria-stabilized zirconia (YSZ) films as intermediate layers on Haynes Alloy No. 230 was developed and characterized. YBaCuO films deposited on these YSZ-coated substrates are primarily c-axis oriented and superconducting as deposited. The best YBaCuO films grow on (001) oriented YSZ intermediate layers and have Tc (R=0) = 86.0 K and Jc ∼ 3×103 A/cm2 at 77 K.
Functional Dyspepsia Symptoms, Gastric Emptying and Satiety Provocative Test: Analysis of Relationships (2001)

The satiety test gives a fine numerical measure of satiety and confirms the results of a symptoms questionnaire. Our study showed an indirect correlation between severity of early satiety--as measured by the satiety test, and gastric emptying rate, as well as an association between bloating and delayed gastric emptying.
A review of image reconstruction techniques for electrical impedance tomography (1989)

There has recently been an increasing interest in the possibility of producing images of electrical impedance within the human body. When an electric current is applied to the body of a voltage distribution is developed across the body surface. This distribution is in part dependent on the internal impedance distribution within the body and it is possible to estimate this distribution from a suitable set of voltage measurements. Because of the nonlinear relationship between the impedance distribution and the voltage distribution at the surface of the body, the reconstruction problem is much more difficult than for other tomographic imaging techniques, but a significant amount of progress has been made, and it is now possible to produce tomographic images of in vivo distributions of impedance, albeit with low spatial resolution. Future developments should improve image quality.
New Copy Number Variations in Schizophrenia (2010)

Genome-wide screenings for copy number variations (CNVs) in patients with schizophrenia have demonstrated the presence of several CNVs that increase the risk of developing the disease and a growing number of large rare CNVs; the contribution of these rare CNVs to schizophrenia remains unknown. Using Affymetrix 6.0 arrays, we undertook a systematic search for CNVs in 172 patients with schizophrenia and 160 healthy controls, all of Italian origin, with the aim of confirming previously identified loci and identifying novel schizophrenia susceptibility genes. We found five patients with a CNV occurring in one of the regions most convincingly implicated as risk factors for schizophrenia: NRXN1 and the 16p13.1 regions were found to be deleted in single patients and 15q11.2 in 2 patients, whereas the 15q13.3 region was duplicated in one patient. Furthermore, we found three distinct patients with CNVs in 2q12.2, 3q29 and 17p12 loci, respectively. These loci were previously reported to be deleted or duplicated in patients with schizophrenia but were never formally associated with the disease. We found 5 large CNVs (>900 kb) in 4q32, 5q14.3, 8q23.3, 11q25 and 17q12 in five different patients that could include some new candidate schizophrenia susceptibility genes. In conclusion, the identification of previously reported CNVs and of new, rare, large CNVs further supports a model of schizophrenia that includes the effect of multiple, rare, highly penetrant variants.
Multiplexed fluorescence detector for capillary electrophoresis using axial optical fiber illumination (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiplexed fluorescence detector for capillary electrophoresis using axial optical fiber illuminationJohn A. Taylor and Edward A. YeungCite this: Anal. Chem. 1993, 65, 7, 956–960Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ac00055a021https://doi.org/10.1021/ac00055a021research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Understanding dental plaque; biofilm dynamics (1997)

A biofilm is a well organized community of cooperating microorganisms. Biofilms predictably form in nature, in artificial environments, and on medically implanted prostheses and indwelling venous catheters. They also form on tooth surfaces in the form of dental plaque. The intent of this article is to aid in the understanding of dental plaque by exploring biofilm structure, nature and dynamics. Understanding plaque facilitates its treatment and control.
Hepatitis-B Surface Antigen (HBsAg) Powder Formulation: Process and Stability Assessment (2006)

The purpose of this study was to develop a hepatitis-B surface antigen (HBsAg) dry powder vaccine formulation suitable for epidermal powder immunization (EPI) via an efficient, scalable powder-formation process. Several HBsAg dry powder formulations were prepared using four different powder-formation methods: freeze-drying/compress/grind/sieve (FD/C/G/S), spray-drying (SD), agarose beads, and spray freeze-drying (SFD). Powder properties and physical stability were determined using particle size analysis, tap density measurement, scanning electron microscopy, optical microscopy, and moisture content analysis. Physical, chemical and biochemical stability of HBsAg was determined by dynamic light scattering, an enzyme immune assay, and immunogenicity in a mouse or hairless guinea pig model. Out of the four powder-formation methods evaluated SFD outperformed other methods in the following considerations: good process efficiency, flexible scalability, and desirable particle characteristics for skin penetration. The stress posed by SFD appeared to be mild as HBsAg in the dry form retained its potency and immunogenicity. Notably, the mechanism of fast freezing by SFD actually promoted the preservation of HBsAg nanoparticle size, in good correlation with long-term biochemical stability. Among several formulations screened, the formulation containing 10 microg HBsAg in 1-mg powder with a tertiary mixture of trehalose, mannitol, and dextran, exhibited excellent overall stability performance. In conclusion, HBsAg dry powder formulations suitable for EPI were successfully prepared using SFD. Further, a systematic formulation development strategy allowed the development and optimization of an HBsAg dry powder formulation, demonstrating excellent long-term physical, biochemical, and immunological stability.
Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. (1992)

We previously reported the cloning of two distinct somatostatin receptor (SSTR) subtypes, SSTR1 and SSTR2. Although both SSTR1 and SSTR2 bound somatostatin specifically and with high affinity, neither was coupled to adenylyl cyclase, a major cellular effector of somatostatin's actions. Here we report the cloning and functional characterization of a third member of the SSTR family. Human SSTR3 is a protein of 418 amino acids and has 45% and 46% identity with human SSTR1 and SSTR2, respectively. RNA blotting studies showed that SSTR3 mRNA could be readily detected in brain and pancreatic islets. The pharmacological properties of human SSTR3 were characterized by transiently expressing the human SSTR3 gene in COS-1 cells. Membranes from cells expressing human SSTR3 bound the somatostatin agonist [125I]CGP 23996 specifically and with high affinity, with a rank order of potency of somatostatin-28 = CGP 23996 > somatostatin-14 > SMS-201-995. Studies using cells transiently coexpressing the human dopamine D1 receptor and human SSTR3 showed that somatostatin was able to inhibit dopamine-stimulated cAMP formation in a dose-dependent manner, indicating that SSTR3 was functionally coupled to adenylyl cyclase. These results indicate that the diverse biological effects of somatostatin are mediated by a family of receptor with distinct, but overlapping, tissue distributions, unique pharmacological properties, and potentially different functions.
In Vivo Gene Transfer Into Injured Carotid Arteries (1995)

This model of focal in vivo adenovirus-mediated gene transfer into the media of injured arteries is highly reproducible and allows high-level recombinant gene expression over a fairly narrow range of virus concentrations. Acute adenovirus-associated tissue toxicity, as demonstrated by medial smooth muscle cell loss and neutrophilic infiltrates, places an upper limit on virus concentration and associated recombinant gene expression and suggests the presence of a "window" of virus concentration in which either therapeutic or biological effects of recombinant genes can be studied in the absence of associated acute toxicity.
Continuous 4–1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy (2013)

Co-stimulation through members of the tumor necrosis factor receptor (TNFR) family appears to be critical for the generation of T cells with optimal effector-memory properties for adoptive cell therapy. Our work suggests that continuous 4-1BB/CD137 co-stimulation is required for the expansion of T cells with an optimal therapeutic profile and that the administration of 4-1BB agonists upon adoptive cell transfer further improves antitumor T-cell functions.
3D Cell Culture (2010)

Developed for a range of tissues where the culture environment takes into account the spatial organization of the cells therein, 3D cell culture models serve to bridge the gap between in vivo studies
A resource allocation model for QoS management (2002)

Quality of service (QoS) has been receiving wide attention in many research communities including networking, multimedia systems, real-time systems and distributed systems. In large distributed systems such as those used in defense systems, on-demand service and inter-networked systems, applications contending for system resources must satisfy timing, reliability and security constraints as well as application-specific quality requirements. Allocating sufficient resources to different applications in order to satisfy various requirements is a fundamental problem in these situations. A basic yet flexible model for performance-driven resource allocations can therefore be useful in making appropriate tradeoffs. We present an analytical model for QoS management in systems which must satisfy application needs along multiple dimensions such as timeliness, reliable delivery schemes, cryptographic security and data quality. We refer to this model as Q-RAM (QoS-based Resource Allocation Model). The model assumes a system with multiple concurrent applications, each of which can operate at different levels of quality based on the system resources available to it. The goal of the model is to be able to allocate resources to the various applications such that the overall system utility is maximized under the constraint that each application can meet its minimum needs. We identify resource profiles of applications which allow such decisions to be made efficiently and in real-time. We also identify application utility functions along different dimensions which are composable to form unique application requirement profiles. We use a video-conferencing system to illustrate the model.
Taxol-induced rose microtubule polymerization in vitro and its inhibition by colchicine. (1984)

Tubulin was isolated from cultured cells of rose (Rosa, sp.cv. Paul's scarlet) by DEAE-Sephadex A50 chromatography, and the taxol-induced polymerization of microtubules in vitro was characterized at 24 degrees C by turbidity development, sedimentation analysis, and electron microscopy. Numerous, short microtubules were formed in the presence of taxol, and maximum levels of turbidity and polymer yield were obtained at approximately 2:1 molar ratios of taxol to tubulin. The critical concentration of rose tubulin for polymerization in saturating taxol was estimated to be 0.21 mg/ml. Colchicine inhibited the taxol-induced polymerization of tubulin as shown by sedimentation assays; however, much higher concentrations of colchicine were required for the inhibition of taxol-induced rose tubulin assembly than for inhibition of taxol-induced mammalian brain tubulin assembly. On the basis of the relative sensitivity of rose tubulin assembly to taxol and its insensitivity to colchicine, we propose that the taxol-binding site(s) on plant and animal tubulins have been more conserved over evolution than the colchicine-binding site(s).
Under the ASABE Umbrella — Engineering Degree Programs Need Curriculum Reform (2014)

Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNFalpha, IL-1beta, and IL-6 and potentiate the expression of the antiinflammatory cytokine IL-10. We report a randomized, single-blind, placebo-controlled, crossover study of testosterone replacement (Sustanon 100) vs. placebo in 27 men (age, 62 +/- 9 yr) with symptomatic androgen deficiency (total testosterone, 4.4 +/- 1.2 nmol/liter; bioavailable testosterone, 2.4 +/- 1.1 nmol/liter). Compared with placebo, testosterone induced reductions in TNFalpha (-3.1 +/- 8.3 vs. 1.3 +/- 5.2 pg/ml; P = 0.01) and IL-1beta (-0.14 +/- 0.32 vs. 0.18 +/- 0.55 pg/ml; P = 0.08) and an increase in IL-10 (0.33 +/- 1.8 vs. -1.1 +/- 3.0 pg/ml; P = 0.01); the reductions of TNFalpha and IL-1beta were positively correlated (r(S) = 0.588; P = 0.003). In addition, a significant reduction in total cholesterol was recorded with testosterone therapy (-0.25 +/- 0.4 vs. -0.004 +/- 0.4 mmol/liter; P = 0.04). In conclusion, testosterone replacement shifts the cytokine balance to a state of reduced inflammation and lowers total cholesterol. Twenty of these men had established coronary disease, and because total cholesterol is a cardiovascular risk factor, and proinflammatory cytokines mediate the development and complications associated with atheromatous plaque, these properties may have particular relevance in men with overt vascular disease.