gebhart/patrepeval huggingface dataset:
The place of family therapy in the Australian undergraduate social work curricula: Literature and research findings (1997)

Abstract Given the renewed interest in the family as a unit of attention and intervention in social work, as evidenced by the family preservation movement and recent family oriented child protection legislation adopted in a number of Australian states, this paper argues that it is important and timely to examine the place of family theory and family therapy in the undergraduate social work curriculum. Drawing on local and international literature, together with relevant findings of a questionnaire survey of Australian social work educators, the paper explores the relevance of family therapy in the social work curriculum and identifies a number of key curriculum issues that are deserving of attention in Australian schools of social work.
Adaptive power amplifier linearization by digital pre-distortion using genetic algorithms (2003)

This paper investigates the application of genetic algorithms to PA linearization using digital pre-distortion with narrowband feedback. An algorithm is presented that adapts a polynomial pre-distortion function to minimize adjacent channel emissions. The paper describes the implementation of this algorithm and compares its performance with a random search technique. Results show nearly optimal performance in a limited number of iterations, suggesting that this technique can be employed as a low-cost solution to meet adjacent channel leakage ratio (ACLR) requirements.
Determination of uranium in environmental samples using inductively coupled plasma mass spectrometry (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of uranium in environmental samples using inductively coupled plasma mass spectrometryD. W. Boomer and M. J. PowellCite this: Anal. Chem. 1987, 59, 23, 2810–2813Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/ac00150a019https://doi.org/10.1021/ac00150a019research-articleACS PublicationsRequest reuse permissionsArticle Views542Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Channel modelling for the fifth generation mobile communications (2014)

The main objective of this paper is to present major challenges regarding the fifth generation (5G) mobile communications propagation modelling work in the European 7 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> framework project METIS (Mobile and wireless communications Enablers for the Twenty-twenty Information Society). The goal of the propagation work in METIS is to provide adequate propagation models for 5G. For this purpose corresponding deficiencies of present commonly used models are identified. Further, the lack of available channel models for several propagation scenarios has been assessed. Based on this assessment the framework of 5G channel modelling is sketched. As propagation measurement campaigns are a crucial part of this work they are illustrated with a few examples.
Endothelial Dysfunction of Coronary Resistance Arteries Is Improved by Tetrahydrobiopterin in Atherosclerosis (2000)

Atherosclerosis severely compromises endothelial function of coronary resistance arteries. Administration of sepiapterin leads to a significant improvement of endothelium-dependent vasodilatation to different agonists in vessels from humans and pigs with atherosclerosis. Therefore, we conclude that a reduced availability of BH4 is involved in the development of endothelial dysfunction in atherosclerosis.
Enfortumab Vedotin Antibody–Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models (2016)

The identification of optimal target antigens on tumor cells is central to the advancement of new antibody-based cancer therapies. We performed suppression subtractive hybridization and identified nectin-4 (PVRL4), a type I transmembrane protein and member of a family of related immunoglobulin-like adhesion molecules, as a potential target in epithelial cancers. We conducted immunohistochemical analysis of 2,394 patient specimens from bladder, breast, lung, pancreatic, ovarian, head/neck, and esophageal tumors and found that 69% of all specimens stained positive for nectin-4. Moderate to strong staining was especially observed in 60% of bladder and 53% of breast tumor specimens, whereas the expression of nectin-4 in normal tissue was more limited. We generated a novel antibody-drug conjugate (ADC) enfortumab vedotin comprising the human anti-nectin-4 antibody conjugated to the highly potent microtubule-disrupting agent MMAE. Hybridoma (AGS-22M6E) and CHO (ASG-22CE) versions of enfortumab vedotin (also known as ASG-22ME) ADC were able to bind to cell surface-expressed nectin-4 with high affinity and induced cell death in vitro in a dose-dependent manner. Treatment of mouse xenograft models of human breast, bladder, pancreatic, and lung cancers with enfortumab vedotin significantly inhibited the growth of all four tumor types and resulted in tumor regression of breast and bladder xenografts. Overall, these findings validate nectin-4 as an attractive therapeutic target in multiple solid tumors and support further clinical development, investigation, and application of nectin-4-targeting ADCs. Cancer Res; 76(10); 3003-13. ©2016 AACR.
HUMORAL INJURY IN PORCINE LIVERS PERFUSED WITH HUMAN WHOLE BLOOD1 (1997)

Based on these results, we suggest that humoral injury is a major cause of liver damage during liver xenoperfusion. The pattern of humoral injury in xenoperfused livers may be attributed to anatomical features of the liver and unique responses of sinusoidal endothelial cells to xenoperfusion.
Rapid Insulin-Like Growth Factor (IGF)-Independent Effects of IGF Binding Protein-3 on Endothelial Cell Survival (2003)

Angiogenic factors, such as vascular endothelial-derived growth factor (VEGF) and IGF-I, play pivotal roles in endothelial proliferation and migration. IGF binding protein-3 (IGFBP-3) is emerging as a key regulator of cell growth and apoptosis, both as an IGF antagonist and as an independent molecule. We investigated the role of IGFBP-3 in VEGFmediated survival of human macrovascular umbilical vein endothelial cells (HUVEC). Specific commercial ELISAs quantified cell proliferation and apoptosis, and Akt phosphorylation was assessed by immunoblots and confocal microscopy. IGF-I and VEGF significantly stimulated HUVEC proliferation and survival. Addition of IGFBP-3 reversed both IGF- and VEGF-induced proliferation and prevented the survival induced by these factors. The antiproliferative and proapoptotic effects of exogenous IGFBP-3 upon VEGF-induced HUVEC survival were not inhibited by blockade of the type 1 IGF receptor with alpha IR-3 immunoglobulin, which fully prevented IGF actions. An IGFBP-3 mutant, which binds IGFs normally but has a substituted mid-region domain, lost the ability to inhibit VEGF actions. VEGF-induced phosphorylation of Akt, as evident by both specific immunoblots and confocal microscopy, was significantly and rapidly reduced in the presence of IGFBP-3, as well as wortmannin.
A Deep Generative Framework for Paraphrase Generation (2017)

Paraphrase generation is an important problem in NLP, especially in question answering, information retrieval, information extraction, conversation systems, to name a few. In this paper, we address the problem of generating paraphrases automatically. Our proposed method is based on a combination of deep generative models (VAE) with sequence-to-sequence models (LSTM) to generate paraphrases, given an input sentence. Traditional VAEs when combined with recurrent neural networks can generate free text but they are not suitable for paraphrase generation for a given sentence. We address this problem by conditioning the both, encoder and decoder sides of VAE, on the original sentence, so that it can generate the given sentence's paraphrases. Unlike most existing models, our model is simple, modular and can generate multiple paraphrases, for a given sentence. Quantitative evaluation of the proposed method on a benchmark paraphrase dataset demonstrates its efficacy, and its performance improvement over the state-of-the-art methods by a significant margin, whereas qualitative human evaluation indicate that the generated paraphrases are well-formed, grammatically correct, and are relevant to the input sentence. Furthermore, we evaluate our method on a newly released question paraphrase dataset, and establish a new baseline for future research.
Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor (1998)

Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic studies had suggested a role for PAF in pregnancy, neuronal cell migration, anaphylaxis, and endotoxic shock. Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemic anaphylactic symptoms. Unexpectedly, however, the PAF receptor-deficient mice developed normally, were fertile, and remained sensitive to bacterial endotoxin. These mutant mice clearly show that PAF plays a dominant role in eliciting anaphylaxis, but that it is not essential for reproduction, brain development, or endotoxic shock.
Adrenomedullin Is Decreased in Preeclampsia Because of Failed Response to Epidermal Growth Factor and Impaired Syncytialization (2003)

To explore the mechanisms of adrenomedullin (ADM) regulation in normal and preeclamptic (PE) states, we determined placental production of ADM and ADM regulation by cytokines. Isolated, purified cytotrophoblast cultures from normal (n=8) and PE (n=10) placentas were cultured for 3 days in the absence or presence of 10 ng/mL epidermal growth factor (EGF), 1 ng/mL transforming growth factor (TGF)-beta1, 10 ng/mL tumor necrosis factor (TNF)-alpha, or 100 U/mL interferon (IFN)-gamma. Cells were also cultured for 3 days in 10% fetal bovine serum for determination of syncytial formation by desmoplakin staining. Pieces of normal and PE placentas were snap-frozen for ADM mRNA measurement. Results showed that basal ADM production into culture medium by radioimmunoassay was significantly lower in PE placental cells. EGF significantly stimulated ADM production in normal trophoblasts but did not in PE placentas. None of the factors TNF-alpha, TGF-beta1, or IFN-gamma altered ADM secretion in either normal or PE placentas. ADM expression by Northern blot analysis demonstrated a 34.3+/-8.3% reduction in mRNA expression in PE placentas. Syncytialization, as assessed by desmoplakin-outlined syncytial units, was decreased in PE placentas (day 3: normal, 16.7+/-1.3%; PE, 5.5+/-2.0%; P<0.01, ANOVA). However, there was a normal increment in syncytialization in response to EGF in normal and PE trophoblast preparations (EGF day 3: normal, 43.8+/-5.6%; PE, 46.1+/-12.3%). We conclude that spontaneous placental syncytialization is impaired in PE and that ADM production is markedly reduced in PE, possibly owing to an impaired EGF response. These abnormalities indicate poor placental production of ADM as the likely cause of a failed compensatory increase in maternal serum ADM levels in PE.
Concise Associated Symptoms Tracking Scale (2011)

Clinicaltrials.gov Identifier: NCT00532103.
Protective Effect of Carbon Monoxide Donor Compounds in Endotoxin-Induced Acute Renal Failure (2007)

Our results suggest the protective effect of the CO donor against endotoxin-induced renal injury; however, further study is needed to elucidate the mechanism.
Isolation and genetic complementation of a sulfolipid-deficient mutant of Rhodobacter sphaeroides (1992)

All photosynthetic organisms are thought to contain the sulfolipid 6-sulfo-alpha-D-quinovosyl diacylglycerol. However, the pathway of sulfolipid biosynthesis has not been elucidated, and the functional or structural significance of this lipid is not known. Mutants of Rhodobacter sphaeroides deficient in sulfolipid accumulation were isolated by directly screening for altered sulfolipid content. The mutants had no apparent phenotype except for the sulfolipid deficiency. A gene, designated sqdA, which complemented one of the mutations was isolated and characterized. The putative sqdA gene product is a protein with a molecular mass of 33.6 kDa that has no sequence similarity to any enzyme of known function.
Identification of somatostatin receptors by covalent labeling with a novel photoreactive somatostatin analog. (1990)

We have synthesized two photoreactive derivatives of somatostatin, namely [125I-Tyr11,azidonitrobenzoyl (ANB)-Lys4]somatostatin and [125I-Tyr11,ANB-Lys9]somatostatin, and used them to characterize somatostatin receptors biochemically in several cell types. Saturation binding experiments carried out in the dark demonstrated that [125I-Tyr11,ANB-Lys4]somatostatin bound with high affinity (KD = 126 +/- 39 pM) to a single class of binding sites in GH4C1 pituitary cell membranes. The affinity of this analog was similar to that of the unsubstituted peptide [125I-Tyr11]somatostatin (207 +/- 3 pM). In contrast, specific binding was not observed with [125I-Tyr11,ANB-Lys9]somatostatin. The binding of both [125I-Tyr11,ANB-Lys4]somatostatin and [125I-Tyr11]somatostatin was potently inhibited by somatostatin (EC50 = 300 pM) whereas at 100 nM unrelated peptides had no effect. Furthermore, both pertussis toxin treatment and guanyl-5'yl imidophosphate (Gpp(NH)p) markedly reduced [125I-Tyr11,ANB-Lys4]somatostatin binding. Thus, [125I-Tyr11,ANB-Lys4]somatostatin binds to G-protein coupled somatostatin receptors with high affinity. To characterize these receptors biochemically, GH4C1 cell membranes were irradiated with ultraviolet light following the binding incubation, and the labeled proteins were identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography. A major band of 85 kDa was specifically labeled with [125I-Tyr11,ANB-Lys4]somatostatin but not with [125I-Tyr11,ANB-Lys9]somatostatin or [125I-Tyr11]somatostatin. The binding affinity of the 85-kDa protein for [125I-Tyr11,ANB-Lys4]somatostatin was very high (Kd = 34 pM). Labeling of this protein was inhibited competitively by somatostatin (EC50 = 140 +/- 80 pM) but not by unrelated peptides. Furthermore, this band was not labeled in pertussis toxin-treated membranes or in untreated membranes incubated with Gpp(NH)p. Finally, [125I-Tyr11,ANB-Lys4]somatostatin specifically labeled bands of 82, 75, and 72 kDa in membranes prepared from mouse pituitary AtT-20 cells, rat pancreatic acinar AR4-2J cells, and HIT hamster islet cells, respectively. Thus, [125I-Tyr11,ANB-Lys4]somatostatin represents the first photolabile somatostatin analog able to bind to receptors with high affinity. Our studies demonstrate that this novel peptide covalently labels specific somatostatin receptors in a variety of target cell types.
Extraluminal air bubble on computed tomography. (1990)

We present two cases of gastrointestinal perforation associated with a tiny extraluminal air bubble on computed tomography (CT). The air bubble was located at the round ligament of the liver in a patient of perforated duodenal ulcer and at the intraperitoneal space adjacent to the perforated site of the anterior gastric wall in the other patient. A small amount of fluid was also seen at the round ligament in the second patient. The region of the round ligament of the liver should be carefully scrutinized for the presence of extraluminal air or fluid in patients with acute abdominal symptomatology.
Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody (2004)

Bispecific single-chain Fv antibodies comprise four covalently linked immunoglobulin variable (V(H) and V(L)) domains of two different specificities connected by three linkers. When assembled in the order V(H)(A)-linker(1)-V(L)(B)-linker(2)-V(H)(B)-linker(3)-V(L)(A), the single-chain molecule either folds head-to-tail with the formation of a diabody-like structure, a so-called bispecific single-chain diabody, or forms a homodimer that is twice as large, a so-called tandem diabody. The formation of the tandem diabody is determined by the association of complementary V(H) and V(L) domains located on different polypeptide chains, and depends on the length and probably the amino acid composition of the three linkers joining the variable domains. We generated a number of single-chain constructs using four V(H) and V(L) domains specific either for human CD3, a component of T-cell receptor (TCR) complex, or for CD19, a human B-cell antigen, separated by different rationally designed peptide linkers of 6-27 amino acid residues. The generated bispecific constructs were expressed in bacterial periplasm and their molecular forms, antigen-binding properties, stability, and T-cell proliferative and anti-tumor activities were compared. Using peripheral blood mononuclear cell cultures from patients suffering from B-cell chronic lymphocytic leukemia, we demonstrated that the tandab-mediated activation of autologous T cells and depletion of malignant cells correlates with the stability of the recombinant molecule and with the distance between the CD19 and CD3 binding sites.
Interferometric modulators for an adaptive nulling system (1993)

Optical intensity modulators with closely matched frequency responses are required for the realization of an optical adaptive nulling system for microwave/millimeter-wave multi-element antenna systems. Traveling-wave interferometric modulators fabricated in lithium niobate have been demonstrated that track to within 0.03 dB and 0.22 deg in amplitude and phase, respectively, over the 5- to 7-GHz frequency band.
The syntheses of radiolabelled org 5222 and its main metabolite org 30526 (1994)

Abstract The syntheses of trans‐5‐chloro‐2, 3, 3a‐12b‐tetrahydro‐2‐methyl‐1H‐dibenz [2, 3:6, 7] oxepino [4, 5‐c]pyrrole (Org 5222), a potential antipsychotic compound, labelled with 3 H, 14 C and 36 C1 and trans‐5‐chloro‐2, 3, 3a, 12b‐tetrahydro‐1H‐dibenz [2, 3:6, 7]‐oxepino [4, 5‐c] pyrrole (Org 30526) labelled with 3 H are described. 3 H‐labelled Org 5222 of low specific activity was prepared by a base catalyzed exchange with tritiated water of an amide precursor, 3 H‐labelled Org 5222 with a high specific activity by a catalytic reductive dehalogenation. 3 H‐labelled Org 30526 was prepared both by demethylation of 3 H‐Org 5222 and by catalytic reductive iodination of 11‐iodo‐Org 30526. 14 C‐labelled Org 5222 was synthesized in 6 steps using 14 C‐sarcosine as starting material. 36 C1‐labelled Org 5222 was prepared by diazotation reaction in the presence of H 36 C1.
Rational design of aggregation-resistant bioactive peptides: Reengineering human calcitonin (2005)

A high propensity to aggregate into intractable deposits is a common problem limiting the production and use of many peptides and proteins in a wide range of biotechnological and pharmaceutical applications. Many therapeutic polypeptides are frequently abandoned at an early stage in their development because of problems with stability and aggregation. It has been shown recently that parameters describing the physicochemical properties of polypeptides can be used as predictors of protein aggregation. Here we demonstrate that these and similar tools can be applied to the rational redesign of bioactive molecules with a significantly reduced aggregation propensity without loss of physiological activity. This strategy has been exemplified by designing variants of the hormone calcitonin that show a significantly reduced aggregation propensity, yet maintain, or even increase, their potency when compared to the current therapeutic forms. The results suggest that this approach could be used successfully to enhance the solubility and efficacy of a wide range of other peptide and protein therapeutics.
Transforming Underwriting in the Life Insurance Industry (2019)

Life insurance provides trillions of dollars of financial security for hundreds of millions of individuals and families worldwide. Life insurance companies must accurately assess individual-level mortality risk to simultaneously maintain financial strength and price their products competitively. The traditional underwriting process used to assess this risk is based on manually examining an applicant’s health, behavioral, and financial profile. The existence of large historical data sets provides an unprecedented opportunity for artificial intelligence and machine learning to transform underwriting in the life insurance industry. We present an overview of how a rich application data set and survival modeling were combined to develop a life score that has been deployed in an algorithmic underwriting system at MassMutual, an American mutual life insurance company serving millions of clients. Through a novel evaluation framework, we show that the life score outperforms traditional underwriting by 6% on the basis of claims. We describe how engagement with actuaries, medical doctors, underwriters, and reinsurers was paramount to building an algorithmic underwriting system with a predictive model at its core. Finally, we provide details of the deployed system and highlight its value, which includes saving millions of dollars in operational efficiency while driving the decisions behind tens of billions of dollars of benefits.
The Role of Viral Glycoproteins in Adsorption, Penetration, and Pathogenicity of Viruses (1980)

Journal Article The Role of Viral Glycoproteins in Adsorption, Penetration, and Pathogenicity of Viruses Get access Purnell W. Choppin, Purnell W. Choppin From the The Rockefeller University, New York, New York Please address requests for reprints to Dr. Purnell W. Choppin, The Rockefeller University, New York, New York 10021. Search for other works by this author on: Oxford Academic PubMed Google Scholar Andreas Scheid Andreas Scheid From the The Rockefeller University, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Reviews of Infectious Diseases, Volume 2, Issue 1, January 1980, Pages 40–61, https://doi.org/10.1093/clinids/2.1.40 Published: 01 January 1980
Welcome to Europe - an Introduction to EU Law for Businesses (2008)

The European Union is a prominent international actor, in both political and economic fora. Yet for many non-Europeans, the exact identity of the European Union is hard to pin down and the implications of the European Union's existence are somewhat nebulous. This article looks at the nature of the European Union and its effect on doing business in modern-day Europe. This article starts by introducing the European Union via its historical roots and core political and economic concerns. It then explores some of the most significant legal ramifications of the European project for carrying on a business in the European Union: the four freedoms; establishment; the Common Commercial Policy; competition; standards; and intellectual property. It concludes with a brief look at what the near future holds for the world's largest market.