gebhart/patrepeval huggingface dataset:
Interaction of forskolin with the P-glycoprotein multidrug transporter (1991)

Forskolin and 1,9-dideoxyforskolin, an analogue that does not activate adenylyl cyclase, were tested for their ability to enhance the cytotoxic effects of adriamycin in human ovarian carcinoma cells, SKOV3, which are sensitive to adriamycin and express low levels of P-glycoprotein, and a variant cell line, SKVLB, which overexpresses the P-glycoprotein and has the multidrug resistance (MDR) phenotype. Forskolin and 1,9-dideoxyforskolin both increased the cytotoxic effects of adriamycin in SKVLB cells, yet had no effect on SKOV3 cells. Two photoactive derivatives of forskolin have been synthesized, 7-O-[[2-[3-(4-azido-3- [125I]iodophenyl)propionamido]ethyl] carbamyl]-7-deacetylforskolin, 125I-7-AIPP-Fsk, and 6-O-[[2-[3-(4-azido-3- [125I]iodophenyl)propionamido]ethyl]carbamyl]forskolin, 125I-6-AIPP-Fsk, which exhibit specificity for labeling the glucose transporter and adenylyl cyclase, respectively (Morris et al., 1991). Both photolabels identified a 140-kDa protein in membranes from SKVLB cells whose labeling was inhibited by forskolin and 1,9-dideoxyforskolin. There was no specific labeling of proteins in membranes from the SKOV3 cells. The overexpressed 140-kDa protein in SKVLB membranes was identified as the P-glycoprotein by immunoblot analysis and immunoprecipitation using anti-P-glycoprotein antiserum. Total inhibition of photolabeling of the P-glycoprotein was observed with verapamil, nifedipine, diltiazem, and vinbalastine, and partial inhibition was observed with colchicine and cytochalasin B. Forskolin was less effective at inhibiting the photolabeling of the P-glycoprotein than 1,9-dideoxyforskolin or a lipophilic derivative of forskolin. The data are consistent with forskolin binding to the P-glycoprotein analogous to that of other chemosensitizing drugs that have been shown to partially reverse MDR.(ABSTRACT TRUNCATED AT 250 WORDS)
Equivalent circuit modeling of symmetric composite right/left-handed coplanar waveguides (2005)

The composite right/left-handed (CRLH) coplanar waveguide (CPW) consisting of the series interdigital capacitor (IDC) and the shunt meandering short-circuited stub inductor (SSI) in symmetric configuration is investigated theoretically and experimentally. To characterize this structure, the equivalent circuit model composed of inductances, capacitances, and resistances to represent the left-handed (LH), right-handed (RH), and lossy characteristics is established. These equivalent circuit elements are extracted simultaneously from S-parameters based on effective medium theory. The extraction method is to examine both the CRLH microstrip line and the CRLH CPW to illustrate the versatility of the formulation. The application of the CRLH CPW in the compact short circuited stub is presented to highlight the unique feature of the CRLH CPW. Compared to the conventional CPW short-circuited stub, the 51.4% length reduction of the case using the CRLH CPW is achieved at 5 GHz.
&lt;title&gt;Low-intensity laser radiation usage in dentistry&lt;/title&gt; (1995)

Low energy laser radiation is widely used in different areas of medicine including dentistry. The main biologic laser radiation action mechanism is its multiangle influence on disease pathogenesis. In clinical practice, the most widely spread equipment is based on helium-neon laser (HNL) with the wavelength of 630 nm. HNL is able to cause different therapeutic effects depending on power flow density, i.e. antiinflammatory, microcirculation stimulation, metabolic, proliferative tissue activity, analgetic. However, considering specific features of oral cavity and parodontium disease pathogenesis, it is necessary to point to a few weak features of HNL. For example, HNL in therapeutic doses has insufficient antimicrobial and antiinflammatory effects; it just decreases microflora pathogeneity in the oral cavity. HNL radiation has poor lithic effect (for example, during the period of debridement) [Prokhonchukov, Zhizhina, Lapidus, 1985]. Regardless of the apparent positive HNL effect following extracorporal or intravascular blood irradiation in cases of generalized acute infection, this method is not used often in dentistry. Therefore, there is a necessity to search for some other more adequate laser irradiation sources which would solve prophylaxis and treatment problems for the most widely spread dental diseases such as caries, parodontosis. As far as a prior aim of laser radiation is to elicit different therapeutic effects, depending on laser beam intensity, the main principle of the treatment should be to vary this as well as wavelength values at different stages of development, duration and pathologic process profylaxis. In order to optimize efficiency of light biostimulators in dentistry it seems of importance to consider theoretical prerequisites of photobiological activation processes and specific activity of different light wavelength effects.
Knudsen compressor as a micro- and macroscale vacuum pump without moving parts or fluids (1999)

Applications of Knudsen compressors as both microscale and macroscale vacuum pumps have been investigated. The study is based on a cascade analysis incorporating available transitional thermal transpiration and Poiseuille flow results for slender channels. It was found that the Knudsen compressor is an attractive possibility for microscale pumps down to a pressure of about 1 mTorr and for macroscale pumps to about 0.1 mTorr. A microscale pump for a micromass spectrometer providing a molecule flow rate of 5×1014 molecules/s results in the following pump characteristics: energy use of 2.4 W, pump volume of 13.9 mℓ at an inlet pressure of 1 mTorr and an energy use of 28.5 mW, and pump volume of 0.16 mℓ at an inlet pressure of 10 mTorr. A macroscale pump providing a pumping speed of 103 ℓ/s results in a pump with an energy use of 1786 W, and pump volume of 1695 ℓ at an inlet pressure of 0.1 mTorr. Several Knudsen compressor characteristics such as pressure rise, pumping speed, volume, energy use and mass flow are presented.
Mobile computing DataMan project perspective (1996)

The objective of mobile computing is to develop system and application level software for small, battery powered terminals equipped with the wireless network connection. There is a rapidly growing interest in this field with companies spending billions of dollars developing technology and buying spectrum in the recent PCS auctions. In this paper we offer a perspective of mobile computing from the standpoint of our own research project at Rutgers University. The DataMan project (T. Imieliński as Project Director and B.R. Badrinath as the CoDirector) is funded by ARPA (within GLOMO program), and two awards from NSF as well as industry support through the industry sponsored Wireless Information Networks Laboratory (WINLAB).
Phlebotomy for Diagnostic Laboratory Tests in Adults (1986)

Although anemia is a frequently observed complication of phlebotomies for laboratory tests in neonates, this problem has received little attention in adult populations. We analyzed the phlebotomy records of 100 hospitalized patients and found that 50 patients who spent all of their hospitalization in general wards had blood samples drawn an average of 1.1 times a day. A mean volume of 12.4 ml a day was drawn, and the total volume drawn during their entire hospitalization was 175.0 ml. In contrast, 50 patients who spent part or all of their hospitalization in an intensive care unit were phlebotomized a mean of 3.4 times a day, for a mean volume of 41.5 ml of blood drawn a day and a total volume of 762.2 ml. Patients in the intensive care unit who had arterial lines had more blood drawn (944.0 ml), more often (4.0 times a day), than patients in the intensive care unit who did not have such lines (300.9 ml; 1.9 times a day). Of 36 patients who received transfusions, 17 (47 percent) had large losses from phlebotomy (greater than 180 ml of red cells) that contributed to their transfusion requirements. We propose the use of sample tubes of the size used in pediatrics, batching of requests for laboratory tests, and review of the cumulative volume of blood removed from individual patients as approaches to reducing blood loss from phlebotomy.
Principles of Model Checking (2008)

A comprehensive introduction to the foundations of model checking, a fully automated technique for finding flaws in hardware and software; with extensive examples and both practical and theoretical exercises. Our growing dependence on increasingly complex computer and software systems necessitates the development of formalisms, techniques, and tools for assessing functional properties of these systems. One such technique that has emerged in the last twenty years is model checking, which systematically (and automatically) checks whether a model of a given system satisfies a desired property such as deadlock freedom, invariants, and request-response properties. This automated technique for verification and debugging has developed into a mature and widely used approach with many applications. Principles of Model Checking offers a comprehensive introduction to model checking that is not only a text suitable for classroom use but also a valuable reference for researchers and practitioners in the field. The book begins with the basic principles for modeling concurrent and communicating systems, introduces different classes of properties (including safety and liveness), presents the notion of fairness, and provides automata-based algorithms for these properties. It introduces the temporal logics LTL and CTL, compares them, and covers algorithms for verifying these logics, discussing real-time systems as well as systems subject to random phenomena. Separate chapters treat such efficiency-improving techniques as abstraction and symbolic manipulation. The book includes an extensive set of examples (most of which run through several chapters) and a complete set of basic results accompanied by detailed proofs. Each chapter concludes with a summary, bibliographic notes, and an extensive list of exercises of both practical and theoretical nature.
Crystal and molecular structure of cephalotaxine p-bromobenzoate (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structure of cephalotaxine p-bromobenzoateS. K. Arora, R. B. Bates, R. A. Grady, and R. G. PowellCite this: J. Org. Chem. 1974, 39, 9, 1269–1271Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://doi.org/10.1021/jo00923a024Request reuse permissionsArticle Views161Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (372 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A Phase I Trial of the Oral, Multikinase Inhibitor Sorafenib in Combination with Carboplatin and Paclitaxel (2008)

The recommended phase II doses are oral 400 mg twice daily sorafenib, carboplatin at an AUC6 dose, and 225 mg/m(2) paclitaxel. The tumor responses observed with this combined regimen in patients with melanoma warrant further investigation.
TBSAM: an access method for efficient processing of statistical queries (1989)

The domain of statistical and scientific databases is targeted here, and the class of aggregate queries which are very often encountered in this domain is considered. Such a query is aimed at retrieving some aggregate characteristics of the raw data. The tree-based statistics access method (TBSAM), which provides support for the efficient processing of aggregate queries, is presented. It is related to the B/sup +/-tree and also processes the B/sup +/-tree's efficient update properties. Complementing TBSAM is the provision of a grouped update algorithm for minimizing expensive indexed database updates.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Self-healing WDM ring networks with all-optical protection path (1992)

Network survivability is necessary for high-speed optical fiber networks, and investigating cost-effective survivable network architectures continues to be important. The ring architecture has been considered as a cost-effective survivable network architecture due to bandwidth sharing and improved survivability.1,2 A self-healing ring is a network architecture that connects a set of offices in a physical ring topology with bandwidth sharing and a self-healing capability to mitigate network component failures. Several self-healing ring architectures using electronic (SONET) add-drop multi-plexers(ADMs) have been proposed3 for telecommunications use.
Carbon / high-k Trench Capacitor for the 40nm DRAM Generation (2007)

Carbon is proposed as a new FEOL material with high conductivity and thermal stability for CMOS integration. Here the application of carbon-based electrodes for future DRAM cell capacitors is presented. Trench capacitors with high-k dielectrics have been realized, fulfilling the requirements for serial resistance, capacitance, leakage, reliability and temperature stability beyond the 40 nm technology node.
Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist‐treated rats (2008)

A better understanding of the mechanisms linked to chemokine pronociceptive effects is essential for the development of new strategies to better prevent and treat chronic pain. Among chemokines, MCP-1/CCL2 involvement in neuropathic pain processing is now established. However, the mechanisms by which MCP-1/CCL2 exerts its pronociceptive effects are still poorly understood. In the present study, we demonstrate that MCP-1/CCL2 can alter pain neurotransmission in healthy rats. Using immunohistochemical studies, we first show that CCL2 is constitutively expressed by primary afferent neurons and their processes in the dorsal horn of the spinal cord. We also observe that CCL2 is co-localized with pain-related peptides (SP and CGRP) and capsaicin receptor (VR1). Accordingly, using in vitro superfusion system of lumbar dorsal root ganglion and spinal cord explants of healthy rats, we show that potassium or capsaicin evoke calcium-dependent release of CCL2. In vivo, we demonstrate that intrathecal administration of CCL2 to healthy rats produces both thermal hyperalgesia and sustained mechanical allodynia (up to four consecutive days). These pronociceptive effects of CCL2 are completely prevented by the selective CCR2 antagonist (INCB3344), indicating that CCL2-induced pain facilitation is elicited via direct spinal activation of CCR2 receptor. Therefore, preventing the activation of CCR2 might provide a fruitful strategy for treating pain.
Nitrogen Partitioning in Maize during Ear Development (1992)

The partitioning of N during the grain‐filling period of maize ( Zea mays L.) was studied under field conditions at differing levels of fertilizer. Two hybrids with differing leaf‐canopy senescence, B73Ht × LHI05 (rapid) and B73Ht × Va35 (slow), were grown with two rates (67 and 257 kg ha −1 ). Separate plants were supplied with 15 N the 14‐leaf stage (VI4), antbesis, or 22 d after anthesis, and the subsequent patterns of 15 N partitioning were followed. Independent of time of application, hybrid, or N fertility, ⊄45% of the 15 N applied was absorbed within 3 d. Three days after the V14 treatment, the stalk contained 50% of the absorbed 15 N, suggesting that it acts as a major sink for N during vegetative growth. With later applications, the 15 N was predominantly partitioned to the ear. Although absorption of total N from soil continued during the grain‐filling period, there was significant remobilization of N from vegetative organs (60 to 85% of the total N present at anthesis) to the ear. Leaves and stalk each contributed 45% of total N remobilized into the ear, and 10% was contributed by the roots. Loss of N from the stalk was initiated before anthesis, whereas it began around anthesis with leaves and roots. The results indicate the important role of the stalk in providing N for kernel development. Both N fertility and hybrid influenced the rate of N remobilization from vegetative tissues.
Rendering trimmed NURBS with adaptive forward differencing (1988)

Trimmed non-uniform rational B-splines have become a very useful surface representation form in the mechanical CAD industry. Previous rendering methods use the de Boor algorithm to evaluate the surface at equal increments in parameter space. This yields polygons which are then rendered. Alternatively the Oslo algorithm and Boehm's knot insertion algorithms are used in a subdivision approach. In this paper a new method is presented for rendering trimmed NURB surfaces of arbitrary order using the adaptive forward differencing (AFD) technique. This method extends the AFD technique to higher order, efficiently computes the basis matrix for each span, calculates the shading approximation functions for rational surfaces, and trims and image maps NURB surfaces. Trimming is accomplished by using AFD to scan convert the trimming curves in parameter space, thus producing the intersection points between the trim curves and an isoparametric curve across the surface. A winding rule is used to determine the regions bounded by the curve which are then rendered with AFD. The method is suitable for both hardware and software implementations, however, higher order surfaces require very high precision due to the forward difference nature of the algorithm.
Insulin‐like growth factor‐I receptor signal transduction and the Janus Kinase/Signal Transducer and Activator of Transcription (JAK‐STAT) pathway (2009)

The insulin-like growth factor IGF-I is an important fetal and postnatal growth factor, which is also involved in tissue homeostasis via regulation of proliferation, differentiation, and cell survival. To understand the role of IGF-I in the pathophysiology of a variety of disorders, including growth disorders, cancer, and neurodegenerative diseases, a detailed knowledge of IGF-I signal transduction is required. This knowledge may also contribute to the development of new therapies directed at the IGF-I receptor or other signaling molecules. In this review, we will address IGF-I receptor signaling through the JAK/STAT pathway in IGF-I signaling and the role of cytokine-induced inhibitors of signaling (CIS) and suppressors of cytokine signaling (SOCS). It appears that, in addition to the canonical IGF-I signaling pathways through extracellular-regulated kinase (ERK) and phosphatidylinositol-3 kinase (PI3K)-Akt, IGF-I also signals through the JAK/STAT pathway. Activation of this pathway may lead to induction of SOCS molecules, well-known feedback inhibitors of the JAK/STAT pathway, which also suppress of IGF-I-induced JAK/STAT signaling. Furthermore, other IGF-I-induced signaling pathways may also be modulated by SOCS. It is conceivable that the effect of these classical inhibitors of cytokine signaling directly affect IGF-I receptor signaling, because they are able to associate to the intracellular part of the IGF-I receptor. These observations indicate that CIS and SOCS molecules are key to cross-talk between IGF-I receptor signaling and signaling through receptors belonging to the hematopoietic/cytokine receptor superfamily. Theoretically, dysregulation of CIS or SOCS may affect IGF-I-mediated effects on body growth, cell differentiation, proliferation, and cell survival.
Conditional generative adversarial network for 3D rigid‐body motion correction in MRI (2019)

The images predicted by the conditional generative adversarial network have quantitatively and qualitatively improved image quality compared to the motion-corrupted images.
Functional properties of subunit interactions in human cytidine deaminase (2003)

An intersubunit interactions study related to the active site has been performed on the wild-type cytidine deaminase (CDA) and on the mutant enzyme F137W/W113F. F137 is the homologous to the Bacillus subtilis CDA F125 involved in the subunit interactions. In the presence of SDS, wild-type human CDA dissociates into enzymatically inactive monomers without intermediate forms via a non-cooperative transition. Extensive dialysis or dilution of the inactivated monomers restores completely the activity. Circular dichroism measurements show that the secondary/tertiary structure organization of each subunit is unaffected by the SDS concentration, while the mutation Phe/Trp causes weakening in quaternary structure. The presence of the strong human CDA competitive inhibitor 5-fluorozebularine disfavours dissociation of the tetramer into subunits in the wild-type CDA, but not in mutant enzyme F137W/W113F. The absence of tyrosine fluorescence and the much higher quantum yield of the double mutant protein spectrum suggest the occurrence of an energy transfer effect between the protein subunits. This assumption is confirmed by the crystallographic studies on B.subtilis in which it is shown that three different subunits concur with the formation of each of the four active sites and that F125, homologous to the human CDA F137, is located at the interface between two different subunits contributing to the formation of active site.
<b>Non-Steroid Anti-Inflammatory Agents</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNon-Steroid Anti-Inflammatory AgentsT. Y. Shen, T. B. Windholz, A. Rosegay, B. E. Witzel, A. N. Wilson, J. D. Willett, W. J. Holtz, R. L. Ellis, A. R. Matzuk, S. Lucas, C. H. Stammer, F. W. Holly, L. H. Sarett, E. A. Risley, G. W. Nuss, and C. A. WinterCite this: J. Am. Chem. Soc. 1963, 85, 4, 488–489Publication Date (Print):February 1, 1963Publication History Published online1 May 2002Published inissue 1 February 1963https://pubs.acs.org/doi/10.1021/ja00887a038https://doi.org/10.1021/ja00887a038research-articleACS PublicationsRequest reuse permissionsArticle Views637Altmetric-Citations136LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts