gebhart/patrepeval huggingface dataset:
Life History of the Invasive Species <i>Halyomorpha halys</i> (Hemiptera: Pentatomidae) in Northeastern United States (2009)

Abstract Host plant use by nymphs and adults of the nonnative species Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) was investigated proximal to the location of its introduction, Allentown, PA. The seasonality of H. halys in the United States had not been thoroughly studied before this work. It is reported to have ≈300 host plants in its native range that could make control and identification of small populations difficult. Weekly beat samples were conducted beginning at petal fall (mid-April) in Pyrus spp. until the first frost (mid-October) from 2005 to 2007 on a variety of ornamental trees, shrubs, and agricultural crops. Egg masses were first observed on Paulownia tomentosa Thunb. the first week of June. In 2006 and 2007, Fraxinus americana L. was an important mid- and late season host for adults. Nymphal abundance differed seasonally. P. tomentosa supported high densities during the early season, whereas Viburnum opulus variety americanum Aiton was the preferred mid-season host, and Viburnum prunifolium L. and Rosa rugosa Thunb. had the highest densities of nymphs during the late season. Abundance of nymphs was strongly associated with maturing fruit or pods. All plants surveyed supported populations of H. halys, suggesting a large host range. In late August, a large adult population peak was observed (850–1,000 degree days [DD]), shortly after the DD accumulation for development to imaginal eclosion, supporting hypotheses that H. halys is likely univoltine in this region. Relative to native pentatomid species, H. halys was by far the predominant species collected in samples on ornamental and cultivated crops.
Bit Cost Scalable (BiCS) flash technology for future ultra high density storage devices (2010)

We've developed Bit Cost Scalable (BiCS) flash technology as a three-dimensional memory for the future ultra high density storage devices, which extremely reduces the chip costs by vertically stacking memory arrays with punch and plug process. We've advanced it to Pipe-shaped BiCS flash memory with U-shaped NAND string, improving the operation window and the reliability and realizing the Multi-Level-Cell (MLC) operation. The functionality has been successfully demonstrated using the 32 Gbit test chip with the 16 stacked layers and the MLC operation by 60nm P-BiCS flash technology.
Effects, quenching mechanisms, and kinetics of carotenoids in chlorophyll-sensitized photooxidation of soybean oil (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects, quenching mechanisms, and kinetics of carotenoids in chlorophyll-sensitized photooxidation of soybean oilSang Hwa Lee and David B. MinCite this: J. Agric. Food Chem. 1990, 38, 8, 1630–1634Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/jf00098a002https://doi.org/10.1021/jf00098a002research-articleACS PublicationsRequest reuse permissionsArticle Views721Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Designing personal assistant software for task management using semantic web technologies and knowledge databases (2013)

Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, Engineering Systems Division, System Design and Management Program, 2013.
Antibodies to a subpopulation of glial cells and a 66 kDa developmental protein in patients with paraneoplastic neurological syndromes. (1996)

The detection of anti-CV2 antibodies in patients with neurological disorders should be considered as an indication of the presence of an occult cancer.
3-Hydroxymethylindoles (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT3-HydroxymethylindolesEdward LeeteCite this: J. Am. Chem. Soc. 1959, 81, 22, 6023–6026Publication Date (Print):November 1, 1959Publication History Published online1 May 2002Published inissue 1 November 1959https://pubs.acs.org/doi/10.1021/ja01531a042https://doi.org/10.1021/ja01531a042research-articleACS PublicationsRequest reuse permissionsArticle Views704Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Automatic placement algorithms for high packing density V L S I (1983)

Five placement procedures which combine three basic algorithms are developed and incorporated to our system. Evaluation of results is presented. Compared with manual design the optimum procedure reduces block size by 6.5%. The normalized area for one transistor (NA) is defined as the measure of automatic layout performance. NA is the product of wiring pitch. Optimum NA is confirmed to be 14.9 for manual design and 13.9 for automatic layout using the optimum procedure. This system is applicable to both custom logic LSIs and masterslice LSIs and has been applied to layouts of many such devices.
Micro/nano liter droplet formation and dispensing by capacitance metering and electrowetting actuation (2003)

In this work, a method is presented for dispensing droplets. The method exploits the built-in capacitance of an electrowetting device to meter the droplet volume and control the dispensing process dynamically. A fully automated droplet dispensing device is developed and used to load liquid samples or couple continuous flow to electro-wetting droplet handling. The reproducibility of the dispensing process is tested against dispensing parameters including dispensing volume, production rate, fluid viscosity, channel geometry and needle diameter. The relative independence of the reproducibility on those parameters indicates the wide applicability of the device in biological and chemical sample dispensing. Meanwhile, as low as 1.2% error in reproducibility is demonstrated and up to 120 droplets per minute production rate is possible. The dispensing process has been demonstrated for droplet volumes between 60 nl and 1900 nl or above while maintain reproducibility in an acceptable range of 10%.
Loop 2 of Ophiophagus hannah Toxin b Binds with Neuronal Nicotinic Acetylcholine Receptors and Enhances Intracranial Drug Delivery (2010)

Three-finger snake neurotoxins have been widely investigated for their high binding affinities with nicotinic acetylcholine receptors (nAChRs), which are widely expressed in the central nervous system including the blood-brain barrier and thus mediate intracranial drug delivery. The loop 2 segments of three-finger snake neurotoxins are considered as the binding domain with nAChRs, and thus, they may have the potential to enhance drug or drug delivery system intracranial transport. In the present work, binding of the synthetic peptides to the neuronal nAChRs was assessed by measuring their ability to inhibit the binding of (125)I-α-bungarotoxin to the receptor. The loop 2 segment of Ophiophagus hannah toxin b (KC2S) showed high binding affinity, and the competitive binding IC(50) value was 32.51 nM. Furthermore, the brain targeting efficiency of KC2S had been investigated in vitro and in vivo. The specific uptake by brain capillary endothelial cells (BCECs) demonstrated that KC2S could be endocytosized after binding with nAChRs. In vivo, the qualitative and quantitative biodistribution results of fluorescent dyes (DiR or coumarin-6) indicated that KC2S modified poly(ethylene glycol)-poly(lactic acid) micelles (KC2S-PEG-PLA micelles) could enhance intracranial drug delivery. Furthermore, intravenous treatment with paclitaxel-encapsulated KC2S-PEG-PLA micelles (KC2S-PEG-PLA-PTX micelles) afforded robust inhibition of intracranial glioblastoma. The median survival time of KC2S-PEG-PLA-PTX-micelle-treated mice (47.5 days) was significantly longer than that of mice treated by mPEG-PLA-PTX micelles (41.5 days), Taxol (38.5 days), or saline (34 days). Compared with the short peptide derived from rabies virus glycoprotein (RVG29) that has been previously reported as an excellent brain targeting ligand, KC2S has a similar binding affinity with neuronal nAChRs but fewer amino acid residues. Thus, we concluded that the loop 2 segment of Ophiophagus hannah toxin b could bind with neuronal nAChRs and thus enhance intracranial drug delivery for the treatment of central nervous system diseases.
Exploring and Exploiting the Effect of Solvent Treatment in Membrane Separations (2017)

It is well-known that solvent treatment and preconditioning play an important role in rejection and flux performance of membranes due to solvent-induced swelling and solvent adsorption. Investigations into the effect of solvent treatment are scarce and application specific, and were limited to a few solvents only. This study reveals the trend in solvent treatment based on solvent polarity in a systematic investigation with the aim to harness such effect for intensification of membrane processes. Nine solvents with polarity indices ranging from 0.1 to 5.8 (hexane to acetonitrile) were used as treatment and process solvents on commercial Borsig GMT-oNF-2, Evonik Duramem 300, and emerging tailor-made polybenzimidazole membranes. TGA-GCMS, HS-GC-FID, and NMR techniques were employed to better understand the effect of solvent treatment on the polymer matrix of membranes. In this work, apart from the solvent treatment's direct effect on the membrane performance, a subsequent indirect effect on the ultimate separation process was observed. Consequently, a pharmaceutical case study employing chlorhexidine disinfectant and antiseptic was used to demonstrate the effect of solvent treatment on the nanofiltration-based purification. It is shown that treatment of polybenzimidazole membranes with acetone resulted in a 25% increase in product recovery at 99% impurity removal. The cost of the process intensification is negligible in terms of solvent consumption, mass intensity, and processing time.
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches (2013)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTReversible Photocontrol of Biological Systems by the Incorporation of Molecular PhotoswitchesWiktor Szymański, John M. Beierle†, Hans A. V. Kistemaker‡, Willem A. Velema, and Ben L. Feringa*View Author Information Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands*E-mail: [email protected]Cite this: Chem. Rev. 2013, 113, 8, 6114–6178Publication Date (Web):April 25, 2013Publication History Received3 May 2012Published online25 April 2013Published inissue 14 August 2013https://doi.org/10.1021/cr300179fCopyright © 2013 American Chemical SocietyRIGHTS & PERMISSIONSACS Editors' ChoiceArticle Views42184Altmetric-Citations905LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (36 MB) Get e-AlertscloseSUBJECTS:Azobenzene,Genetics,Irradiation,Monomers,Peptides and proteins Get e-Alerts
Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution (2008)

Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor that plays a crucial role in interleukin-6 (IL-6) signaling, mediating the acute-phase induction of the human Angiotensinogen (hAGT) gene in hepatocytes. We showed earlier that IL-6 induces acetylation of the STAT3 NH(2)-terminus by the recruitment of the p300 coactivator. We had also observed a physical interaction of STAT3 and Histone Deacetylase1 (HDAC1) in an IL-6-dependent manner that leads to transcriptional repression. In this study, we sought to elucidate the mechanism by which HDAC1 controls STAT3 transcriptional activity. Here, we mapped the interacting domains of both STAT3 and HDAC1 and found that the COOH-terminal domain of HDAC1 is necessary for IL-6-induced STAT3 transcriptional repression, whereas the NH(2)-terminal acetylation domain of STAT3 is required for HDAC1 binding. Interestingly, over expression of HDAC1 in HepG2 cells leads to significantly reduced amounts of nuclear STAT3 after IL-6 induction, whereas silencing of HDAC1 resulted in accumulation of total and acetylated STAT3 in the nucleus. We have found that HDAC1 knockdown also interferes with the responsiveness of the STAT3-dependent MCP1 target gene expression to IL-6, as confirmed by real-time RT-PCR analysis. Together, our study reveals the novel functional consequences of IL-6-induced STAT3-HDAC1 interaction on nucleocytoplasmic distribution of STAT3.
YQA14: a novel dopamine D<sub>3</sub>receptor antagonist that inhibits cocaine self‐administration in rats and mice, but not in D<sub>3</sub>receptor‐knockout mice (2011)

The dopamine (DA) D3 receptor is posited to be importantly involved in drug reward and addiction, and D3 receptor antagonists have shown extraordinary promise as potential anti-addiction pharmacotherapeutic agents in animal models of drug addiction. SB-277011A is the best characterized D3 receptor antagonist in such models. However, the potential use of SB-277011A in humans is precluded by pharmacokinetic and toxicity problems. We here report a novel D3 receptor antagonist YQA14 that shows similar pharmacological properties as SB-277011A. In vitro receptor binding assays suggest that YQA14 has two binding sites on human cloned D3 receptors with K(i-High) (0.68 × 10(-4) nM) and K(i-Low) (2.11 nM), and displays > 150-fold selectivity for D3 over D2 receptors and > 1000-fold selectivity for D3 over other DA receptors. Systemic administration of YQA14 (6.25-25 mg/kg) or SB-277011A (12.5-25 mg/kg) significantly and dose-dependently reduced intravenous cocaine self-administration under both low fixed-ratio and progressive-ratio reinforcement conditions in rats, while failing to alter oral sucrose self-administration and locomotor activity, suggesting a selective inhibition of drug reward. However, when the drug dose was increased to 50 mg/kg, YQA14 and SB-277011A significantly inhibited basal and cocaine-enhanced locomotion in rats. Finally, both D3 antagonists dose-dependently inhibited intravenous cocaine self-administration in wild-type mice, but not in D3 receptor-knockout mice, suggesting that their action is mediated by D3 receptor blockade. These findings suggest that YQA14 has a similar anti-addiction profile as SB-277011A, and deserves further study and development.
Quaternary Structure of Casein Kinase 2 (1995)

The structure-activity relationship of casein kinase 2 (CK2) was examined with regard to its previously reported property to self-aggregate in vitro. Sedimentation velocity and electron microscopy studies showed that the purified kinase exhibited four major, different oligomeric forms in aqueous solution. This self-polymerization was a reproducible and fully reversible process, highly dependent upon the ionic strength of the medium, suggesting that electrostatic interactions are mostly involved. At high salt concentrations (e.g. 0.5 M NaCl), CK2 appears as spherical moieties with a 18.7 +/- 1.6 nm average diameter, roughly corresponding to the alpha 2 beta 2 protomer, as deduced by measurements of the Stokes radius and by light scattering studies. At lower ionic strength (e.g. 0.2 M NaCl), the protomers associate to form ring-like structures with a diameter (averaging 36.6 +/- 2.1 nm) and Stokes radius indicating that they are most likely made of four circularly associated alpha 2 beta 2 protomers. At 0.1 M NaCl, two additional polymeric structures were visualized: thin filaments (16.4 +/- 1.4 nm average), as long as 1 to 5 microns, and thick and shorter filaments (28.5 +/- 1.6 nm average). Examination of the molecular organization of CK2 under different catalytic conditions revealed that the ring-like structure is the favored conformation adopted by the enzyme in the presence of saturating concentrations of substrates and cofactors. During catalysis, well-known cofactors like MgCl2 or spermine are the main factors governing the stabilization of the active ring-like structure. On the other hand, inhibitory high salt concentrations promote the dissociation of the active ring-like structure into protomers. Such observations suggest a strong correlation between the ring-like conformation of the enzyme and optimal specific activity. Thus, CK2 may be considered as an associating-dissociating enzyme, and this remarkable property supports the hypothesis of a cooperative and allosteric regulation of the kinase in response to appropriate regulatory ligands possibly taking place in intact cells.
Service-Based Layered Architectural Model for Building Collaborative Applications in Heterogeneous Environments (2009)

The development of collaborative applications should take into account static and dynamic issues, as well as different technological aspects that allow adapting them to either several working groups’ needs or new collaborative scenarios, since these applications have to be continuously running its correct functionality. For this reason, this paper presents a service-based layered architectural model which provides the appropriate infrastructure to support the inherent complexity of the development of long-time, scalable, complex and adaptable collaborative applications in heterogeneous environments, so that these applications allow carrying out effectively group work. Every model layer is briefly explained and an example of a collaborative application built with our architectural model is shown. The application we have chosen for this purpose is a Conference Management System.
Treatment with ImuVert/JV-Acetylcysteine Protects Rats from Cyclophosphamide/ Cytarabine-Induced Alopecia (1992)

Chemotherapy-induced alopecia is a distressing problem to the cancer patient for which currently there is no effective preventive measure. Recently ImuVert, a biologic response modifier, has been shown to protect from cytarabine-induced alopecia in the young rat model, but not from alopecia induced by cyclophosphamide. In the present study, the rat model was used to examine the effect of N-acetylcysteine on the course of alopecia from cyclophosphamide and of ImuVert plus N-acetylcysteine on alopecia induced by cytarabine-cyclophosphamide combination. The following observations were made: (1) Cyclophosphamide-induced alopecia could be effectively prevented by N-acetylcysteine, administered parenterally or applied topically in liposomes. (2) Alopecia caused by the combination of cyclophosphamide and cytarabine could be prevented by the parenteral or topical administration of ImuVert plus N-acetylcysteine. The potential applicability of these observations to the clinical settings remains to be determined.
Pose-driven Deep Convolutional Model for Person Re-identification (2017)

Feature extraction and matching are two crucial components in person Re-Identification (ReID). The large pose deformations and the complex view variations exhibited by the captured person images significantly increase the difficulty of learning and matching of the features from person images. To overcome these difficulties, in this work we propose a Pose-driven Deep Convolutional (PDC) model to learn improved feature extraction and matching models from end to end. Our deep architecture explicitly leverages the human part cues to alleviate the pose variations and learn robust feature representations from both the global image and different local parts. To match the features from global human body and local body parts, a pose driven feature weighting sub-network is further designed to learn adaptive feature fusions. Extensive experimental analyses and results on three popular datasets demonstrate significant performance improvements of our model over all published state-of-the-art methods.
Comparison of triphenyltetrazolium dye with light microscopic evaluation in a rabbit model of acute cerebral ischaemia (1994)

The present study was performed to compare brain infarct size assessment by routine histology (haematoxylin and eosin) and by 2,3,5-triphenyltetrazolium chloride staining techniques. New Zealand white rabbits were subjected to autologous clot embolization to the anterior circulation of the brain. After a study period of 7-8 h the brains were harvested and serially sectioned in the coronal plane. Brain slices were then immersed in a 1% triphenyltetrazolium chloride dye. Following visualization of the infarcted region, the brains were immediately placed in 10% formalin and later prepared for histologic evaluation by routine haematoxylin and eosin. The two methods were compared for their ability to estimate infarct size by an independent observer. There was excellent correlation between the two methodologies; infarct sizes of 57.4 +/- 5.0% versus 55.9 +/- 5.4% (mean +/- SEM, p < 0.007, r = 0.73, n = 12; expressed as percentage of the hemisphere infarcted) were noted for light microscopic evaluation versus triphenyltetrazolium chloride staining, respectively. It is concluded that triphenyltetrazolium chloride staining is an acceptable method for delineating brain infarct size in this rabbit model of thromboembolic stroke. The relative ease of infarct size determination with this technique suggests its more widespread use in similar models.