gebhart/patrepeval huggingface dataset:
Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product (1999)

Heme-binding protein 23 kDa (HBP23), a rat isoform of human proliferation-associated gene product (PAG), is a member of the peroxiredoxin family of peroxidases, having two conserved cysteine residues. Recent biochemical studies have shown that HBP23/PAG is an oxidative stress-induced and proliferation-coupled multifunctional protein that exhibits specific bindings to c-Abl protein tyrosine kinase and heme, as well as a peroxidase activity. A 2.6-A resolution crystal structure of rat HBP23 in oxidized form revealed an unusual dimer structure in which the active residue Cys-52 forms a disulfide bond with conserved Cys-173 from another subunit by C-terminal tail swapping. The active site is largely hydrophobic with partially exposed Cys-173, suggesting a reduction mechanism of oxidized HBP23 by thioredoxin. Thus, the unusual cysteine disulfide bond is involved in peroxidation catalysis by using thioredoxin as the source of reducing equivalents. The structure also provides a clue to possible interaction surfaces for c-Abl and heme. Several significant structural differences have been found from a 1-Cys peroxiredoxin, ORF6, which lacks the C-terminal conserved cysteine corresponding to Cys-173 of HBP23.
他人与我们 的苦难同样使上帝伤心——一个神学家对9.11事件的思考 (2002)

时光飞逝,“9·11”已过一年,据悉,“9·11”一词已被美国语言专家正式编入《美国传统词典》。正当美国各大传媒争相秋祭“9·11”时,一位美国的神学家,却客观冷静地对这个过程思辨,一个健康的世界是否需要人们在其中承担特殊的责任!杜思托也夫斯基有一句名言,“倘若没有上帝,一切都会被容许”。
A fail-safe mechanism for maintaining self-tolerance. (1992)

Using cytotoxic T lymphocyte (CTL) responses to the class I histocompatibility antigen Qa1 and to the minor histocompatibility antigen H-Y, we show that the immune system maintains a peripheral screening process that is able to tolerize a wide variety of potentially autoimmune CTL. The critical factor is the presence or absence of specific T helper cells. If T help is available, CTL precursors that recognize antigen are activated. In the absence of help, they are tolerized. Thus, T helper cells are guardians of peripheral tolerance in CTL.
A Fast and Robust GJK Implementation for Collision Detection of Convex Objects (1999)

Abstract This paper presents an implementation of the Gilbert-Johnson-Keerthi algorithm for comput ing the distance between convex objects, that has improved performance, robustness, and versatility over earlier implementations. The algorithm presented here is especially suitable for use in collision detection of objects modeled using various types of geometric primitives, such as boxes, cones, and spheres, and their images under affine transformation.
Enhanced protection against respiratory influenza A infection in mice by liposome-encapsulated antibody. (1994)

Liposome-mediated passive immunity was evaluated for its efficacy in the prophylaxis and treatment of influenza A/PR/8 virus infection in mice. A mouse LD50 protection model was developed using a polyclonal anti-influenza A antibody which demonstrated strong reactivity against the mouse-adapted virus in a fluorogenic enzyme immunoassay and in an in vitro plaque assay. Using liposomes as an antibody carrier system, the delivery of antibody to the lungs was optimized. For mice given the antiviral antibody intranasally 24 h prior to challenge with 10 LD50 of mouse-adapted influenza A/PR/8 virus, the survival rate at 14 days post-challenge was 60%. However, when mice were given antibody encapsulated within liposomes, the survival rate increased to 100%. In the treatment of mice preinfected with 10 LD50 of the virus, mice were fully protected (100% survival rate) when treated within 8 hr post-infection with free unencapsulated antibody, or within 12 hr with liposome-encapsulated antibody. It is postulated that the improved therapeutic and prophylactic efficacies of the antiviral antibody may be attributed to enhanced delivery as well as retention of antibody molecules in the lungs when liposomes are used as antibody carrier system.
Focus cues affect perceived depth (2005)

Depth information from focus cues--accommodation and the gradient of retinal blur--is typically incorrect in three-dimensional (3-D) displays because the light comes from a planar display surface. If the visual system incorporates information from focus cues into its calculation of 3-D scene parameters, this could cause distortions in perceived depth even when the 2-D retinal images are geometrically correct. In Experiment 1 we measured the direct contribution of focus cues to perceived slant by varying independently the physical slant of the display surface and the slant of a simulated surface specified by binocular disparity (binocular viewing) or perspective/texture (monocular viewing). In the binocular condition, slant estimates were unaffected by display slant. In the monocular condition, display slant had a systematic effect on slant estimates. Estimates were consistent with a weighted average of slant from focus cues and slant from disparity/texture, where the cue weights are determined by the reliability of each cue. In Experiment 2, we examined whether focus cues also have an indirect effect on perceived slant via the distance estimate used in disparity scaling. We varied independently the simulated distance and the focal distance to a disparity-defined 3-D stimulus. Perceived slant was systematically affected by changes in focal distance. Accordingly, depth constancy (with respect to simulated distance) was significantly reduced when focal distance was held constant compared to when it varied appropriately with the simulated distance to the stimulus. The results of both experiments show that focus cues can contribute to estimates of 3-D scene parameters. Inappropriate focus cues in typical 3-D displays may therefore contribute to distortions in perceived space.
Halofuginone Inhibits T <sub>H</sub> 17 Cell Differentiation by Activating the Amino Acid Starvation Response (2009)

A central challenge for improving autoimmune therapy is preventing inflammatory pathology without inducing generalized immunosuppression. T helper 17 (TH17) cells, characterized by their production of interleukin-17, have emerged as important and broad mediators of autoimmunity. Here we show that the small molecule halofuginone (HF) selectively inhibits mouse and human TH17 differentiation by activating a cytoprotective signaling pathway, the amino acid starvation response (AAR). Inhibition of TH17 differentiation by HF is rescued by the addition of excess amino acids and is mimicked by AAR activation after selective amino acid depletion. HF also induces the AAR in vivo and protects mice from TH17-associated experimental autoimmune encephalomyelitis. These results indicate that the AAR pathway is a potent and selective regulator of inflammatory T cell differentiation in vivo.
Ultrasonic Welding of Metal/Composite Joints (2004)

Ultrasonic metal welding joins load‐bearing glass fibres of composites or pure glass fibres directly to metal sheets. The weldings reach tensile shear strengths of up to 23 MPa. A possible application is given in the Figure which shows aluminium sheets welded to a composite (left) and a glass fibre fabric (right).
[Radiation measurement and dose assessment]. (2012)

In order to assess an effective dose, it is necessary to evaluate the external exposure caused by gamma ray or neutron, and the internal exposure caused by ingestion from contaminated food or soil and inhalation from radioactive fallout. It is also necessary to consider the equivalent dose of the skin in case of the existence of a high density surface contamination by beta emitters. An early evaluation on the effective dose should be indispensable by a dose calculation using easy expression and by a suitable radiation measurement for the radiation emergency. The accuracy of the effective dose may not be significant at the first stage, but the true value should be included in the range of the fluctuation. Here, radiation measurement is the most effective means to be able to avoid the misjudgment.
Bacterial Community Variation in Human Body Habitats Across Space and Time (2009)

Elucidating the biogeography of bacterial communities on the human body is critical for establishing healthy baselines from which to detect differences associated with diseases. To obtain an integrated view of the spatial and temporal distribution of the human microbiota, we surveyed bacteria from up to 27 sites in seven to nine healthy adults on four occasions. We found that community composition was determined primarily by body habitat. Within habitats, interpersonal variability was high, whereas individuals exhibited minimal temporal variability. Several skin locations harbored more diverse communities than the gut and mouth, and skin locations differed in their community assembly patterns. These results indicate that our microbiota, although personalized, varies systematically across body habitats and time; such trends may ultimately reveal how microbiome changes cause or prevent disease.
Dynamic effects of pair correlation functions on spin relaxation by translational diffusion in liquids. II. Finite jumps and independent <i>T</i>1 processes (1978)

Hwang and Freed have previously given solutions for the relative diffusion of molecules that include the proper boundary condition (i.e., an excluded volume due to a distance of minimum approach) which has usually been neglected in spin relaxation theories. In this work their results are extended to include effects of (1) one type of spin that is rapidly relaxing, (2) diffusion by jumps of finite size, and (3) frequency-dependent diffusion coefficients in the theory of spin relaxation by intermolecular dipolar interactions. These results are mathematically simpler and sounder than those commonly employed. In particular, it is shown that for case (2) measurements of J (O), the zero-frequency spectral density cannot solely be used to determine the jump size, in constrast to the Torrey theory, which did not consider the boundary-value problem.
A rate nephelometer for measuring specific proteins by immunoprecipitin reactions. (1977)

A kinetic nephelometric method and instrument have been developed for the rapid determination of specific serum proteins by means of immunoprecipitin reactions. The maximum rate of change of scattered light intensity in an antigen-antibody reaction can be made to occur within 60 s after initiation of the reaction and provides a measure of the antigen concentration under antibody excess conditions. A mathematical relationship has been found for the conversion of the nonlinear maximum rate data directly into a linear concentration read-out, making possible the use of single-point calibration. Instrument operating parameters and computations are programmed for a particular analysis by means of machine-readable cards. Antigen-excess samples are detected rapidly by injection of calibrator into the reaction mixture after the rate signal has dropped to a pre-selected level. The method correlates well with both radial immunodiffusion and end-point nephelometric methods.
Neonatal Therapeutic Intervention Scoring System: A Therapy-Based Severity-of-Illness Index (1992)

Severity-of-illness scales have proven valuable in assessing clinical outcomes and resource consumption in adult and pediatric intensive care, but they have been less extensively developed for neonatal care. The National Therapeutic Intervention Scoring System (NTISS) was created by modifying the Therapeutic Intervention Scoring System (TISS). From the 76 original TISS items, 42 were deleted and 28 added to form the NTISS. Like TISS, NTISS assigns score points from 1 to 4 for various intensive care therapies. Admission-day NTISS scores were calculated for 1643 newborns admitted to three neonatal intensive care units (NICUs) between November 1, 1989, and September 30, 1990. NTISS scores ranged from 0 to 47 with a mean of 12.3 +/- 8.7 (SD). There was little correlation with birth weight (r = -.11) or gestational age (r = -.17), but NTISS scores were highly correlated with expected markers of illness severity, including mortality risk estimates by neonatal attending physicians (r = .70, P < .0001), in-hospital mortality rates (P < .05), and a measure of nursing acuity (Medicus) (r = .69, P < .0001). In addition, admission-day NTISS scores were found to be predictive of both NICU length of stay (r = .37, P < .0001) and total hospital charges for survivors (r = .65, P < .0001). It is concluded that NTISS is a valid measure of therapeutic intensity that is independent of birth weight and can be used as an indicator of neonatal illness severity and resource utilization. Further validation in other NICUs is required.
<i>Experiments in Modern Physics</i> (1967)

Share Icon Share Twitter Facebook Reddit LinkedIn Reprints and Permissions Cite Icon Cite Search Site Citation Adrian C. Melissinos, Fay Ajzenberg‐Selove; Experiments in Modern Physics. Physics Today 1 March 1967; 20 (3): 117. https://doi.org/10.1063/1.3034195 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPhysics Today Search Advanced Search
Changes in the Matrix Proteins of Wool and Mouse Hair Following the Administration of Depilatory Compounds (1980)

After sheep were defleeced with mimosine, cyclophosphamide or N-[5-(4-aminophenoxy)pentyl]-phthalimide, the first samples of the new growth of wool differed markedly in composition from the pretreatment samples, there being substantial reductions in the high-tyrosine proteins and increases in the high-sulfur proteins. Similar results were obtained with mice dehaired with mimosine and with sheep treated with low levels of mimosine which resulted in weakened wool rather than depilation. The composition of later samples of the regrowth wool showed progressive changes with time. The high-tyrosine proteins tended to approach the pretreatment levels, although this may take up to 12 weeks to occur, whereas the levels of high-sulfur proteins, after the initial increase, often fell below normal. In experiments involving defleecing with cyclophosphamide, the level of the latter proteins was still below normal after 3 months. The possibility that this altered protein composition of keratin fibres is characteristic of that portion of fibre first produced by a new or regenerating follicle was investigated in sheep and mice. It was found that wool follicles regenerating after plucking, and newly operating follicles in young sheep and mice, also produced wool and hair with a reduced content of high-tyrosine proteins. It is suggested, therefore, that the apparent long-term inhibition of the high-tyrosine proteins may not be the direct consequence of the administration of the chemical but rather be characteristic of normal wool and hair regrowth. Infusion of an amino acid mixture lacking methionine into the abomasum of sheep caused the growth of weak wool but did not suppress the synthesis of the high-tyrosine proteins. This is in contrast with previous findings that treatments which weaken wool also suppress high-tyrosine proteins.
Cerebro-oculo-facio-skeletal syndrome: report of two cases from Turkey with postmortem findings. (2002)

We describe two cases of COFS (cerebro-oculo-facio-skeletal) syndrome in two newborn females of consanguineous parents. The clinical, radiological and pathological features of the patients are presented. One of the two cases had 11 pairs of ribs (Case 1) and the other had three-lobed left lung (Case 2), neither of which has been described in COFS syndrome previously. To our knowledge, these are the first reported cases of COFS syndrome from Turkey.
Discovery of Novel Antitumor Sulfonamides Targeting G1 Phase of the Cell Cycle (1999)

Described herein is the discovery of a novel series of antitumor sulfonamides targeting G1 phase of the cell cycle. Cell cycle control in G1 phase has attracted considerable attention in recent cancer research, because many of the important proteins involved in G1 progression or G1/S transition have been found to play a crucial role in proliferation, differentiation, transformation, and programmed cell death (apoptosis). We previously reported our first antitumor sulfonamide E7010 as a novel tubulin polymerization inhibitor. Interestingly enough, continuous research on structurally related compounds led us to the finding of another class of antitumor sulfonamides that block cell cycle progression of P388 murine leukemia cells in G1 phase, but not in M phase. Of the compounds examined, N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide (E7070) showed significant antitumor activity against HCT116 human colon carcinoma both in vitro (IC(50) 0.11 microg/mL in cell proliferation assay) and in vivo (not only growth suppression but also a marked reduction of tumor size in nude mice). Because of its promising efficacy against human tumor xenografts and its unique mode of action, E7070 is currently undergoing phase I clinical trials in European countries.
Topical betamethasone for prevention of radiation dermatitis (2007)

Prophylactic and ongoing use of topical betamethasone 0.1% during chest wall RT for breast cancer delays occurrence of ARD but does not prevent it. Petrolatum has no effect on the prevention of ARD in these patients.
Dominating IgE-Binding Epitope of Bet v 1, the Major Allergen of Birch Pollen, Characterized by X-ray Crystallography and Site-Directed Mutagenesis (2003)

Specific allergy vaccination is an efficient treatment for allergic disease; however, the development of safer vaccines would enable a more general use of the treatment. Determination of molecular structures of allergens and allergen-Ab complexes facilitates epitope mapping and enables a rational approach to the engineering of allergen molecules with reduced IgE binding. In this study, we describe the identification and modification of a human IgE-binding epitope based on the crystal structure of Bet v 1 in complex with the BV16 Fab' fragment. The epitope occupies approximately 10% of the molecular surface area of Bet v 1 and is clearly conformational. A synthetic peptide representing a sequential motif in the epitope (11 of 16 residues) did not inhibit the binding of mAb BV16 to Bet v 1, illustrating limitations in the use of peptides for B cell epitope characterization. The single amino acid substitution, Glu(45)-Ser, was introduced in the epitope and completely abolished the binding of mAb BV16 to the Bet v 1 mutant within a concentration range 1000-fold higher than wild type. The mutant also showed up to 50% reduction in the binding of human polyclonal IgE, demonstrating that glutamic acid 45 is a critical amino acid also in a major human IgE-binding epitope. By solving the three-dimensional crystal structure of the Bet v 1 Glu(45)-Ser mutant, it was shown that the change in immunochemical activity is directly related to the Glu(45)-Ser substitution and not to long-range structural alterations or collapse of the Bet v 1 mutant tertiary structure.
Phylogeny and Molecular Evolution of the Green Algae (2012)

The green lineage (Viridiplantae) comprises the green algae and their descendants the land plants, and is one of the major groups of oxygenic photosynthetic eukaryotes. Current hypotheses posit the early divergence of two discrete clades from an ancestral green flagellate. One clade, the Chlorophyta, comprises the early diverging prasinophytes, which gave rise to the core chlorophytes. The other clade, the Streptophyta, includes the charophyte green algae from which the land plants evolved. Multi-marker and genome scale phylogenetic studies have greatly improved our understanding of broad-scale relationships of the green lineage, yet many questions persist, including the branching orders of the prasinophyte lineages, the relationships among core chlorophyte clades (Chlorodendrophyceae, Ulvophyceae, Trebouxiophyceae and Chlorophyceae), and the relationships among the streptophytes. Current phylogenetic hypotheses provide an evolutionary framework for molecular evolutionary studies and comparative genomics. This review summarizes our current understanding of organelle genome evolution in the green algae, genomic insights into the ecology of oceanic picoplanktonic prasinophytes, molecular mechanisms underlying the evolution of complexity in volvocine green algae, and the evolution of genetic codes and the translational apparatus in green seaweeds. Finally, we discuss molecular evolution in the streptophyte lineage, emphasizing the genetic facilitation of land plant origins.
A New Base‐Labile Anchoring Group for Polymer‐Supported Peptide Synthesis (1984)

Abstract A new base‐labile anchoring group, derived from 9‐(hydroxymethyl)fluorene‐4‐carboxylic acid (HO 2 CFmoH or HOFmCO 2 H; 7), for polymer‐supported peptide synthesis os described. The synthesis of 7 starting from 2,2′‐biphenyldicarboxylic acid ( 1 ) proceeds in an overall yield of 53%. The group HO 2 CFmo exhibits properties similar to the well known Fmoc protecting group: It is stable to acidic conditions and cleavable by 15% piperidine in DMF. In combination with acid labile N α ‐protecting groups (e.g. Boc, Ddz, Bpoc, Nps etc. ), it renders more flexibility to the stepwise synthesis using polymer supports. The versatility of the new anchoring group in solid‐ and liquid‐phase peptide synthesis is demonstrated for the synthesis of a model peptide.
Downlink beamforming for mobile radio systems with frequency division duplex (2002)

The capacity of cellular mobile radio systems can be increased with smart antennas. The following two concepts can be utilized. First, smart antennas enable the concept of space division multiple access (SDMA) so that transmission from a base station to several mobiles at the same time and carrier frequency is possible. Second, cochannel interference in cellular systems can be reduced so that the frequency reuse is improved. The purpose of downlink beamforming is to transmit as much power as possible to the desired mobile and as little power as possible to any undesired mobile. In the case of systems with frequency division duplex (FDD) the fast fading processes for uplink and downlink are different. But, if the frequency separation is not too large, the uplink and downlink waves exhibit the same directional dependence. Therefore, downlink beamforming has to be carried out in an average sense based on the uplink channel measurements. The paper discuss the optimization of downlink beamforming for systems with FDD. It answers the question whether beamforming should be optimized in such a way that the transmitted power is mainly sent into the direction of the path with minimum average attenuation or whether it is better to distribute the power to all desired paths. The advantage from concentrating the power to the main path is that the interference power to other mobiles may be reduced due to a higher degree of freedom for beamforming. In the case of power distribution on all paths, the advantage from higher path diversity may be obtained.
Regioselective reductive ring-opening of 4-methoxybenzylidene acetals of hexopyranosides. Access to a novel protecting-group strategy. Part 1 (1984)

Reduction of fully protected 4,6-O-(4-methoxybenzylidene) hexopyranosides with sodium cyanoboro-hydride–trifluoroacetic acid in NN′-dimethylformamide, or trimethylsilyl chloride in acetonitrile, gives the 6- and 4-O-(4-methoxybenzyl) ethers, respectively, in good yield and good regioselectivity. The 4-methoxybenzyl ether linkage in products containing benzyl ethers or other protective groups is selectively cleaved upon treatment with cerium(IV) ammonium nitrate in aqueous acetonitrile.