gebhart/patrepeval huggingface dataset:
Antisickling properties of the fermented mixture of Carica papaya Linn and Sorghum bicolor (L.) Moench (2009)

The antisickling properties of fermented mixture of dried unripe fruit pulp of Carica papaya and dried Sorghum bicolor leaves, mixed in equal proportions in distilled water, was carried out using sodium metabisulphite sickled red blood cells and the result presented. Equal weight of dried C. papaya fruit pulp and S. bicolor leaves were fermented together in distilled water at room temperature and the aqueous extract obtained and used for antisickling assays. The extract gotten from the materials incubated for 5 days indicated as SP5, was found to have the highest antisickling properties with 93% inhibitory and 84% reversal activities. The concentration of the day 5 extract was further varied. 0.2 ml was found to be the optimum volume of the test extracts.
Utilization-Based Resource Partitioning for Power-Performance Efficiency in SMT Processors (2010)

Simultaneous multithreading (SMT) increases processor throughput by allowing parallel execution of several threads. However, fully sharing processor resources may cause resource monopolization by a single thread or other misallocations, resulting in overall performance degradation. Static resource partitioning techniques have been suggested, but are not as effective as dynamic ones since program behavior does change over the course of its execution. In this paper, we propose an Adaptive Resource Partitioning Algorithm (ARPA) that dynamically assigns resources to threads according to changes in thread behavior. ARPA analyzes the resource usage efficiency of each thread in a given time period and assigns more resources to threads which can use them more efficiently. Its purpose is to improve the efficiency of resource utilization, thereby improving overall instruction throughput. Our simulation results on a set of 42 multiprogramming workloads show that ARPA outperforms the traditional fetch policy ICOUNT by 55.8 percent with regard to overall instruction throughput and achieves a 33.8 percent improvement over Static Partitioning. It also outperforms the current best dynamic resource allocation technique, Hill-climbing, by 5.7 percent. Considering fairness accorded to each thread, ARPA attains 43.6, 18.5, and 9.2 percent improvements over ICOUNT, Static Partitioning, and Hill-climbing, respectively, using a common fairness metric. We also explore the energy efficiency of dynamically controlling the number of powered-on reorder buffer entries for ARPA. Compared with ARPA, our energy-aware resource partitioning algorithm achieves 10.6 percent energy savings, while the performance loss is negligible.
Preliminary characterization of an epitope involved in neutralization and cell attachment that is located on the major bovine rotavirus glycoprotein (1985)

The 38,200-molecular weight (unreduced)/41,900-molecular-weight (reduced) glycoprotein of bovine rotavirus, isolate C486, was identified as the major neutralizing antigen. This glycoprotein as well as the corresponding glycoprotein of another bovine rotavirus serotype also specifically attached to cell monolayers under normal conditions for virus adsorption in vitro. Further support for this glycoprotein being directly responsible for virus attachment to cells was that (i) infectious virus of both serotypes could compete with the C486 glycoprotein for cell surface receptors, and (ii) neutralizing monospecific antiserum and neutralizing monoclonal antibodies directed toward the glycoprotein could block this virus-cell interaction. Preliminary epitope mapping of the glycoprotein with monoclonal antibodies further localized the neutralization-adsorption domain to a peptide with an approximate molecular weight of 14,000. The effect of two protein modifications, glycosylation and disulfide bridging, on the reactivity of this peptide with antibodies and cell surface receptors was investigated. It was demonstrated that, whereas glycosylation did not appear to affect these reactivities, disulfide bridging seemed to be essential.
Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1α,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance (2012)

Recent clinical trials aimed at improved treatment of AML by administration of vitamin D derivatives showed unremarkable results, suggesting development of vitamin D resistance in patients' AML blasts. Since mechanisms of vitamin D resistance are not clear, we studied 40AF cells, a subline of HL60 cells that can proliferate in the presence of 1α,25-dihydroxyvitamin D₃ (1,25D). We found that mRNA and protein levels of HPK1, an upstream MAP4 kinase, are dramatically increased in 40AF cells, and HPK1 protein is further increased when the 1,25D resistance of 40AF cells is partially reversed by the addition of carnosic acid and p38MAPK inhibitor SB202190 (DCS cocktail). Knockdown of HPK1 reduces 1,25D/DCS-induced differentiation of both 1,25D-sensitive HL60 and U937 cells and 1,25D-resistant 40AF cells, but the effect of HPK1 knockdown on differentiation-associated G 1 arrest is more apparent in the resistant than the sensitive cells. To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases. Accordingly, inhibition of proteolysis with the pan-caspase inhibitor Q-VD-OPh reduced HPK1 cleavage and enhanced DCS-induced differentiation of 40AF cells. The results indicate that FL-HPK1 is a positive regulator of vitamin D-induced differentiation in AML cells, but the cleaved HPK1 fragment inhibits differentiation. Thus, high HPK1 cleavage activity contributes to vitamin D resistance, and HPK1 has a dual role in AML cell differentiation.
Deletion of Alloantigen-Activated Cells by Aminolevulinic Acid-Based Photodynamic Therapy (1999)

Abstract— Protoporphyrin IX (PpIX), an endogenously synthesized photosensitizer, can transiently accumulate in activated lymphocytes following administration of the heme precursor 5-aminolevulinic acid (ALA). One possible mechanism of this in lymphocyte accumulation is that actively dividing cells use intracellular iron stores for cytochrome and DNA synthesis and thus do not inactivate PpIX, the photoactive precursor of heme, by iron incorporation. This selective accumulation in activated cells should allow targeting by photodynamic therapy (PDT). To determine the effect of this accumulation, we studied PDT effects on the in vitro correlate of transplantation rejection: the one-way mixed lymphocyte reaction (MLR). Selective phototoxicity was determined by photoirradiating ALA-treated, MLR-activated cells and measuring subsequent stimulation either in a secondary MLR or with phytohemagglutinin (PHA). We found that proliferation of MLR-activated lymphocytes incubated with ALA and treated with light was only 12–20% of controls (ALA+, no light) after rechallenge with the stimulator cells (P < 0.05), although their response to nonspecific PHA stimulation was similar to controls. Thus alloantigen-specific depletion was shown. The data suggest a role for ALAPDT in the treatment of diseases that require the selective elimination of activated lymphocytes and possibly as an immunomodulator.
Pustular Psoriasis Induced by Hydroxychloroquine: A Case Report and Review of the Literature (1996)

A variety of pharmacologic agents have been known to induce pustular psoriasis. We describe a patient with a positive personal and family history of psoriasis who developed an extensive annular pustular eruption 3 weeks after starting hydroxychloroquine (Plaquenil) for arthritis. The drug was discontinued, and she received 3 weeks of systemic and topical corticosteroids; in spite of the therapeutic intervention, showers of new lesions appeared daily, and progressed to involve 75% of the body. The development of new lesions stopped, and the older lesions began to clear after one dose of 7.5 mg of methotrexate. Subsequently, methotrexate therapy was stopped because of mild transaminase elevation; the pustular lesions then flared. New lesions stopped appearing after four doses of weekly methotrexate. The patient remains clear of lesions 6 months later.
The Preparation of Some Fluoroalkylmethyldichlorosilanes and their Hydrolysis Products<sup>1</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Some Fluoroalkylmethyldichlorosilanes and their Hydrolysis Products1Paul Tarrant, G. W. Dyckes, Robert Dunmire, and G. B. ButlerCite this: J. Am. Chem. Soc. 1957, 79, 24, 6536–6540Publication Date (Print):December 1, 1957Publication History Published online1 May 2002Published inissue 1 December 1957https://pubs.acs.org/doi/10.1021/ja01581a049https://doi.org/10.1021/ja01581a049research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multinozzle Emitter Array Chips for Small-Volume Proteomics (2012)

High-throughput multiplexed proteomics of small-volume biospecimens will generate new opportunities in theranostics. Achieving parallel top-down and bottom-up mass spectrometry analyses of target proteins using a unified apparatus will improve proteome characterization. We have developed a novel silicon-based microfluidic device, multinozzle emitter array chip (MEA chip), as a new platform for small-volume proteomics using liquid chromatography-nanoelectrospray ionization mass spectrometry (LC-nanoESI-MS). We demonstrate parallel, on-chip, and online LC-MS analysis of hemoglobin and its tryptic digests directly from microliters of blood, achieving a detection limit of less than 5 red blood cells. Our MEA chip will enable clinical proteomics of small-volume samples.
Fluctuation driven ratchets: Molecular motors (1994)

The motion of a heavily damped Brownian particle in a periodic potential subject to a dichotomously fluctuating perturbation is considered. We show that even if the net force is always zero, flow is induced by a fluctuation of the energy barrier, but only at flipping times roughly in between the adiabatic adjustment times on the left and right of the barrier. Predictions of our model are consistent with recent experimental data obtained by Svoboda et al. [Nature (London) 365, 721--727 (1993)] for a single kinesin molecule moving along a biopolymer.
Thickness dependences of optical constants for thin layers of some metals and semiconductors (2001)

The review comprises investigations devoted to determination of refractive index and absorption coefficient dependences on thickness for thin films of metals and atomic semiconductors.
The combination of systemic antibiotics and antibiotics impregnated cement in primary total knee arthroplasty in patients of rheumatoid arthritis--evaluation of 60 knees. (2003)

Cefuroxime-impregnated cement combining with systemic antibiotics seems to be effective in the prevention of early or intermediate deep infection in primary TKA in patients of RA.
Identification of<i>Listeria monocytogenes</i>Genes Involved in Salt and Alkaline-pH Tolerance (2003)

The capacity of Listeria monocytogenes to tolerate salt and alkaline stresses is of particular importance, as this pathogen is often exposed to such environments during food processing and food preservation. We screened a library of Tn917-lacZ insertional mutants in order to identify genes involved in salt and/or alkaline tolerance. We isolated six mutants sensitive to salt stress and 12 mutants sensitive to salt and alkaline stresses. The position of the insertion of the transposon was located in 15 of these mutants. In six mutants the transposon was inserted in intergenic regions, and in nine mutants it was inserted in genes. Most of the genes have unknown functions, but sequence comparisons indicated that they encode putative transporters.
The role of myo-inositol in multiple sclerosis. (1986)

Myo-inositol was given orally to nine multiple sclerosis patients and nine healthy control subjects. Pattern reversal evoked potential testing was used to assess its effect. The principal positive wave increased in amplitude, duration and area in a dose-dependent manner in the multiple sclerosis group compared with controls. Cerebrospinal fluid concentrations of myo-inositol in multiple sclerosis and controls were similar. The significance of these observations is discussed in relation to recent discoveries in inositol phospholipid function.
Studies of hypolipidemic agents. I. Syntheses and hypolipidemic activities of 1-substituted 2-alkanone derivatives. (1986)

Many 1-substituted 2-alkanone derivatives were synthesized and their inhibitory activities toward pancreatic lipase and esterase were examined in order to obtain hypolipidemic agents. 1-Benzenesulfonyloxy-2-pentanone (VI-2a) and 1-(2, 4, 6-trimethylbenzenesulfonyloxy)-2-pentanone (VI-2q) exhibited not only potent and selective esterase inhibitions (IC50 : 9.0×10-7M and 1.0×10-6M, respectively), but also potent hypolipidemic action (90 and 92% reductions of plasma triglyceride, and 53 and 90% reductions of plasma total cholesterol, respectively). A novel working hypothesis is presented to account for the lowering of the plasma lipids level, i.e., that inhibition of esterase and lipase activities in the small intestinal lumen may be responsible for the decrease in the plasma lipids level.
Combination of Phosphatidylinositol 3‐Kinases Pathway Inhibitor and Photodynamic Therapy in Endothelial and Tumor Cells (2012)

Tumor recurrence due to incomplete eradication of tumor cells is a major problem facing current cancer therapies. To overcome this problem, it is necessary to enhance cell killing and/or prevent cell regrowth after treatment. Because phosphatidylinositol 3-kinases (PI3K) pathway plays an important role in stimulating cell survival and growth, we studied the feasibility of using a PI3K pathway inhibitor NVP-BEZ235 (BEZ235) to enhance the effectiveness of vascular-targeted photodynamic therapy (vPDT) with verteporfin. We found that BEZ235 or PDT alone significantly inhibited cell growth in both SVEC endothelial and PC-3 prostate cancer cells, although SVEC cells appeared to be more responsive than PC-3 cells. Autophagy was detected after both BEZ235 and verteporfin-PDT in both cell lines. Autophagy appeared to protect cells from PDT-induced cell death because inhibition of autophagy increased cell death. Autophagic flux assay revealed that PDT actually decreased autophagic flux especially at a high dose of verteporfin. Combination of BEZ235 and PDT caused greater inhibition of PI3K signaling pathway, leading to enhanced cell growth inhibition in both cell lines. SVEC cells exhibited a higher sensitivity towards such a combination than PC-3 cells. Our data indicated that BEZ235 in combination with PDT provides a promising approach of enhancing therapeutic response.
A Versatile Bifunctional Chelate for Radiolabeling Humanized Anti-CEA Antibody with In-111 and Cu-64 at Either Thiol or Amino Groups: PET Imaging Of CEA-Positive Tumors with Whole Antibodies (2007)

Radiolabeled anti-carcinoembryonic antigen (CEA) antibodies have the potential to give excellent images of a wide variety of human tumors, including tumors of the colon, breast, lung, and medullar thyroid. In order to realize the goals of routine and repetitive clinical imaging with anti-CEA antibodies, it is necessary that the antibodies have a high affinity for CEA, low cross reactivity and uptake in normal tissues, and low immunogenicity. The humanized anti-CEA antibody hT84.66-M5A (M5A) fulfills these criteria with an affinity constant of >10 (10) M (-1), no reactivity with CEA cross-reacting antigens found in normal tissues, and >90% human protein sequence. A further requirement for routine clinical use of radiolabeled antibodies is a versatile method of radiolabeling that allows the use of multiple radionuclides that differ in their radioemissions and half-lives. We describe a versatile bifunctional chelator, DO3A-VS (1,4,7-tris(carboxymethyl)-10-(vinylsulfone)-1,4,7,10-tetraazacyclododecane) that binds a range of radiometals including 111 In for gamma-ray imaging and 64Cu for positron emission tomography (PET), and which can be conjugated with negligible loss of immunoreactivity either to sulfhydryls (SH) in the hinge region of lightly reduced immunoglobulins or surface lysines (NH) of immunoglobulins. Based on our correlative studies comparing the kinetics of radiolabeled anti-CEA antibodies in murine models with those in man, we predict that 64Cu-labeled intact, humanized antibodies can be used to image CEA positive tumors in the clinic.
Development of HIV-1 resistance to (−)2′-deoxy-3′-thiacytidine in patients with AIDS or advanced AIDS-related complex (1995)

Objective: To determine the rate of development of in vitro HIV resistance to (-)2′-deoxy-3′-thiacytidine (3TC) and relate the effect of dose to emergence of resistance. Methods: HIV-infected men and non-pregnant women, aged ≥ 18 years, with a CD4 count ≤ 300 × 106/l cells were fòllowed in a Phase I/II study, in which they were evaluated for tolerance to 3TC and effect of this agent with regard to viral susceptibility. Peripheral blood and plasma samples were collected at regular intervals for analysis. HIV was isolated using umbilical cord blood mononuclear cells as targets. These cells were also used in determinations of median inhibitory drug concentration. Specific amplification of the 184 mutation site, associated with HIV resistance to 3TC, was performed by polymerase chain reaction, using specific primer pairs, on DNA harvested from infected peripheral blood mononuclear cells (PBMC) of donors or, alternatively, on DNA that had been reverse transcribed from plasma-associated HIV RNA. Results: Phenotypic resistance was detected in approximately one-third of individuals studied, who were followed between 8 and 56 weeks. Development of 3TC resistance occurred independently of dose, although time of first appearance of resistant HIV-1 variants appeared reduced at high 3TC doses. Amino-acid changes at codon 184 in HIV-1 reverse transcriptase were associated with, and preceded, the development of phenotypic 3TC resistance. Most commonly, a Met to Ile substitution appeared transiently before being superceded by a Val substitution at codon 184. Conclusions: In vitro resistance to 3TC developed in a high proportion of subjects who received prolonged monotherapy with this drug. The development of resistance to 3TC was associated with appearance of mutated viral forms and the disappearance of wild-type virus, with regard to codon 184, in both patient plasma and PBMC. AIDS 1995, 9:351-357
Electron-beam lithography with metal colloids: Direct writing of metallic nanostructures (1998)

We report on the fabrication of metallic nanostructures in the sub-100 nm region by means of electron-beam lithography with metal colloids. A thin organometallic film consisting of surfactant stabilized Pd-colloids (⩽3 nm) is directly patterned by electron-beam irradiation. Non-exposed colloids are easily removed by rinsing the sample with appropriate dissolvers. The metallic character of the nanostructures is checked by resistance measurements. We find the morphology and the resistance behavior of the present nanostructured Pd-colloids to be similar to those of granular thin Pd/C films. Accordingly, the metal content of the nanostructures fabricated with Pd-colloids can be estimated.
MATRIX-FREE NUMERICAL CONTINUATION AND BIFURCATION<sup>*</sup> (2001)

A numerical continuation method traces solution branches of a nonlinear system which is typically obtained by discretizing a parameter dependent operator equation. The method is called matrix-free if the Jacobian of H is not calculated explicitly, but its action on a vector is given via a difference approximation of a directional derivative. In connection with modern (transpose-free) iterative linear solvers, this is a suitable approach for large systems. We give an introduction into the technique of matrix-free numerical continuation and analyze those recent approaches to numerical bifurcation which permit a matrix-free approach. A sequence of MATLAB codes, which can be viewed as a blueprint for the numerical implementation of this approach, is currently under construction and will be made available on the internet. Parts of this manuscript are based on the 200 page article [2] Allgower, E. L. and Georg, K. 1997. “Numerical path following”. In Handbook of Numerical Analysis Edited by: Ciarlet, P. G. and Lions, J. L. Vol. 5, 3–207. North-Holland. [Crossref] , [Google Scholar].
Compartmentalization of bicarbonate‐sensitive adenylyl cyclase in distinct signaling microdomains (2002)

Intracellular targets of the ubiquitous second messenger cAMP are located at great distances from the most widely studied source of cAMP, the G protein responsive transmembrane adenylyl cyclases. We previously identified an alternative source of cAMP in mammalian cells lacking transmembrane spanning domains, the "soluble" adenylyl cyclase (sAC). We now demonstrate that sAC is distributed in specific subcellular compartments: mitochondria, centrioles, mitotic spindles, mid-bodies, and nuclei, all of which contain cAMP targets. Distribution at these intracellular sites proves that adenylyl cyclases are in close proximity to all cAMP effectors, suggesting a model in which local concentrations of cAMP are regulated by individual adenylyl cyclases targeted to specific microdomains throughout the cell.
A polypeptide drug carrier for maternal delivery and prevention of fetal exposure (2014)

These data indicate that ELP does not cross the placenta, and they suggest that this adaptable drug delivery system is a promising platform for prevention of fetal drug exposure.
Predicting Multivariate Responses in Multiple Linear Regression (1997)

Summary We look at the problem of predicting several response variables from the same set of explanatory variables. The question is how to take advantage of correlations between the response variables to improve predictive accuracy compared with the usual procedure of doing individual regressions of each response variable on the common set of predictor variables. A new procedure is introduced called the curds and whey method. Its use can substantially reduce prediction errors when there are correlations between responses while maintaining accuracy even if the responses are uncorrelated. In extensive simulations, the new procedure is compared with several previously proposed methods for predicting multiple responses (including partial least squares) and exhibits superior accuracy. One version can be easily implemented in the context of standard statistical packages.