gebhart/patrepeval huggingface dataset:
Boosting for document routing (2000)

Article Boosting for document routing Share on Authors: Raj D. Iyer Living Wisdom School, 456 College Avenue, Palo Alto, CA and AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJ Living Wisdom School, 456 College Avenue, Palo Alto, CA and AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJView Profile , David D. Lewis AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJ AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJView Profile , Robert E. Schapire AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJ AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJView Profile , Yoram Singer School of Computer Science & Engineering, The Hebrew University, Jerusalem 91904, Israel and AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJ School of Computer Science & Engineering, The Hebrew University, Jerusalem 91904, Israel and AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJView Profile , Amit Singhal AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJ AT&T Labs - Research, Shannon Laboratory, 180 Park Avenue, Florham Park, NJView Profile Authors Info & Claims CIKM '00: Proceedings of the ninth international conference on Information and knowledge managementNovember 2000 Pages 70–77https://doi.org/10.1145/354756.354794Online:06 November 2000Publication History 24citation502DownloadsMetricsTotal Citations24Total Downloads502Last 12 Months6Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Microarray-Based Analysis of Cell-Cycle Gene Expression During Spermatogenesis in the Mouse1 (2010)

Mammalian spermatogenesis is a continuum of cellular differentiation in a lineage that features three principal stages: 1) a mitotically active stage in spermatogonia, 2) a meiotic stage in spermatocytes, and 3) a postreplicative stage in spermatids. We used a microarray-based approach to identify changes in expression of cell-cycle genes that distinguish 1) mitotic type A spermatogonia from meiotic pachytene spermatocytes and 2) pachytene spermatocytes from postreplicative round spermatids. We detected expression of 550 genes related to cell-cycle function in one or more of these cell types. Although a majority of these genes were expressed during all three stages of spermatogenesis, we observed dramatic changes in levels of individual transcripts between mitotic spermatogonia and meiotic spermatocytes and between meiotic spermatocytes and postreplicative spermatids. Our results suggest that distinct cell-cycle gene regulatory networks or subnetworks are associated with each phase of the cell cycle in each spermatogenic cell type. In addition, we observed expression of different members of certain cell-cycle gene families in each of the three spermatogenic cell types investigated. Finally, we report expression of 221 cell-cycle genes that have not previously been annotated as part of the cell cycle network expressed during spermatogenesis, including eight novel genes that appear to be testis-specific.
Thermal Stability of Structural Aluminum in the Mesoporous Molecular Sieve MCM-41 (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal Stability of Structural Aluminum in the Mesoporous Molecular Sieve MCM-41Zhaohua Luan, Chi-Feng Cheng, Heyong He, and Jacek KlinowskiCite this: J. Phys. Chem. 1995, 99, 26, 10590–10593Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/j100026a023https://doi.org/10.1021/j100026a023research-articleACS PublicationsRequest reuse permissionsArticle Views478Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis (2002)

Juvenile Batten disease (JNCL) is an autosomal recessive disease that results from mutations in the CLN3 gene. The wild-type CLN3 gene coding sequence has 15 exons, and the translated protein consists of 438 amino acids. The most commonly observed mutation is a 1.02 kb deletion in the genomic DNA. This deletion results in a truncated protein due to the loss of amino acids 154-438, and the introduction of 28 novel amino acids at the c-terminus. We demonstrate that, compared to normal controls, CLN3-deficient immortalization of lymphoblasts homozygous for this deletion grow at a slower rate, and show increased sensitivity to etoposide-induced apoptosis, supporting the notion that CLN3 may negatively regulate apoptosis. Using immortalized JNCL lymphoblast cell lines as a model system, we assess the effects of specific CLN3 mutations on cell growth rates and protection from etoposide-induced apoptosis. Protection from etoposide-induced apoptosis occurs and the cell growth rate is restored following transfection of JNCL lymphoblasts with mutant CLN3 cDNA that includes exons 11 or 13. We show that deletion of the glycosylation sites 71NQSH74 and 310NTSL313, and also mutations within the highly conserved amino acid stretches 184WSSGTGGAGLLG195, 291VYFAE295 and 330VFASRSSL337, result in slowed growth and susceptibility to apoptosis.
Thermal Decomposition of Metal Acetylacetonates: Mass Spectrometer Studies (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal Decomposition of Metal Acetylacetonates: Mass Spectrometer StudiesJoan Von Hoene, Robert G. Charles, and William M. HickamCite this: J. Phys. Chem. 1958, 62, 9, 1098–1101Publication Date (Print):September 1, 1958Publication History Published online1 May 2002Published inissue 1 September 1958https://pubs.acs.org/doi/10.1021/j150567a019https://doi.org/10.1021/j150567a019research-articleACS PublicationsRequest reuse permissionsArticle Views4314Altmetric-Citations162LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Imaging Molecular Chemistry with Infrared Microscopy (1999)

Wetzel and LeVine describe a new analytical tool that uses infrared radiation and a combination of microscopy and spectroscopy to quantify the chemical composition of microscopic samples. They discuss the many applications of FT-IR microspectroscopy in forensics, materials science, art restoration and bi-ology and how future fine-tuning of the methodology will broaden the number of applications.
Statistical physics inspired energy-efficient coded-modulation for optical communications (2012)

Because Shannon's entropy can be obtained by Stirling's approximation of thermodynamics entropy, the statistical physics energy minimization methods are directly applicable to the signal constellation design. We demonstrate that statistical physics inspired energy-efficient (EE) signal constellation designs, in combination with large-girth low-density parity-check (LDPC) codes, significantly outperform conventional LDPC-coded polarization-division multiplexed quadrature amplitude modulation schemes. We also describe an EE signal constellation design algorithm. Finally, we propose the discrete-time implementation of D-dimensional transceiver and corresponding EE polarization-division multiplexed system.
Early experience with a commercial hardware transactional memory implementation (2009)

We report on our experience with the hardware transactional memory (HTM) feature of two pre-production revisions of a new commercial multicore processor. Our experience includes a number of promising results using HTM to improve performance in a variety of contexts, and also identifies some ways in which the feature could be improved to make it even better. We give detailed accounts of our experiences, sharing techniques we used to achieve the results we have, as well as describing challenges we faced in doing so.
Improved textured surfaces for implantable prostheses. (1989)

Textured surfaces have been shown to reduce scar tissue formation around implanted prostheses compared with identical smooth surface controls in applications such as compliance chambers for artificial heart systems. The authors have developed and evaluated alternative textured surfaces to the polyester velour surface that has been used on those devices. These new textured surfaces are fabricated with materials known to provoke a diminished tissue response compared with polyester fibers. Two new textured surfaces have been examined: a surface composed of extruded 25 micron diameter polyurethane fibrils (PF) woven into a fabric, and an integrally textured silicone rubber surface (TS) with nonfibril geometry applicable to silicone rubber implants such as mammary prostheses. In both cases, tissue fixation to the textured surface depends primarily on mechanical interdigitation with the complicated surface morphology of the implant rather than on chemical bonding. Two types of control were employed: polyester velour fabric (PV) as a textured surface, and smooth silicone rubber (SS). Each surface was first characterized with scanning electron microscopy (SEM), and test specimens consisting of 1 cm diameter by 1 mm thickness disks were then prepared and implanted subcutaneously in a series of 16 adult New Zealand white rabbits. After 8 weeks the samples were explanted and histologic sections prepared for analysis. In all cases a thin, organized tissue capsule surrounded the implant. While the tissue capsule on average was thinner surrounding the textured surface implants, variations in the individual host response were more significant. Tissue attachment was minimal with SS, present with PF, and greatest with TS and PV.(ABSTRACT TRUNCATED AT 250 WORDS)
Low‐level light stimulates excisional wound healing in mice (2007)

LLLT stimulates wound contraction in susceptible mouse strains but the mechanism remains uncertain.
Experimental feasibility of multi-energy photon-counting K-edge imaging in pre-clinical computed tomography (2008)

Theoretical considerations predicted the feasibility of K-edge x-ray computed tomography (CT) imaging using energy discriminating detectors with more than two energy bins. This technique enables material-specific imaging in CT, which in combination with high-Z element based contrast agents, opens up possibilities for new medical applications. In this paper, we present a CT system with energy detection capabilities, which was used to demonstrate the feasibility of quantitative K-edge CT imaging experimentally. A phantom was imaged containing PMMA, calcium-hydroxyapatite, water and two contrast agents based on iodine and gadolinium, respectively. Separate images of the attenuation by photoelectric absorption and Compton scattering were reconstructed from energy-resolved projection data using maximum-likelihood basis-component decomposition. The data analysis further enabled the display of images of the individual contrast agents and their concentrations, separated from the anatomical background. Measured concentrations of iodine and gadolinium were in good agreement with the actual concentrations. Prior to the tomographic measurements, the detector response functions for monochromatic illumination using synchrotron radiation were determined in the energy range 25 keV-60 keV. These data were used to calibrate the detector and derive a phenomenological model for the detector response and the energy bin sensitivities.
ariatric Surgery for Morbid Obesity: Health mplications for Patients, Health Professionals, nd Third-Party Payers (2005)

c his Consensus Statement on the state of bariatric surery for morbid obesity has been prepared by a panel of roadly based and experienced experts based on presenations by investigators working in areas relevant to curent questions in this field during a 11⁄2-day public sesion; questions and statements from conference ttendees during open discussion periods that were part f the public sessions; and closed deliberations by the anel. This statement is an independent report of the anel and is not a policy statement of the American ociety for Bariatric Surgery or any of the sponsors or ndorsers of the Consensus Conference. Though the onsensus Conference is modeled on the format used by he National Institutes of Health (NIH), the planning, xecution, and development of the conference and prepration of this statement were carried out without any elationship with the NIH. In addition, although the onference was addressed by the Honorable Tommy hompson, Secretary of Health and Human Services, his report is not a policy statement of the federal overnment. This statement reflects the panel’s assessment of medcal knowledge available at the time it was written. nowledge about bariatric surgery and morbid obesity is
The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans (2004)

Remote ischemic preconditioning (IPC) reduces tissue injury caused by ischemia-reperfusion (IR) in distant organs. We tested the hypothesis that remote IPC (rIPC) modifies inflammatory gene transcription in humans. Using a microarray method, we demonstrated that a simple model of brief forearm ischemia suppresses proinflammatory gene expression in circulating leukocytes. Genes encoding key proteins involved in cytokine synthesis, leukocyte chemotaxis, adhesion and migration, exocytosis, innate immunity signaling pathways, and apoptosis were all suppressed within 15 min (early phase IPC) and more so after 24 h (second window IPC). Changes in leukocyte CD11b expression measured by flow cytometry mirrored this pattern, with there being a significant (P = 0.01) reduction at 24 h. The results of this study show that the rIPC stimulus modifies leukocyte inflammatory gene expression. This effect may contribute to the protective effect of IPC against IR injury and may have broader implications in other inflammatory processes. This is the first study of human gene expression following rIPC stimulus. rIPC stimulus suppressed proinflammatory gene transcription in human leukocytes.
Epidemic of Aseptic Peritonitis Caused by Endotoxin during Chronic Peritoneal Dialysis (1977)

Of all episodes of peritonitis among patients undergoing chronic peritoneal dialysis 15 to 30 per cent1,2 are described as aseptic — that is, all symptoms and signs of peritonitis are present, but cultures of the effluent are negative. No responsible agent has been identified to date.An epidemic of 48 episodes of aseptic peritonitis occurred during a four-week period among 28 patients maintained on chronic peritoneal dialysis in two hospitals. Dialysate in 2-liter plastic containers was used in all cases.Diffuse abdominal pain and rebound tenderness were the predominant findings, occurring on an average of seven hours after initiation of . . .
Host-mediated selection of influenza virus receptor variants. Sialic acid-alpha 2,6Gal-specific clones of A/duck/Ukraine/1/63 revert to sialic acid-alpha 2,3Gal-specific wild type in ovo. (1985)

Human and animal influenza A isolates of the H3 serotype preferentially bind SA alpha 2,6Gal or SA alpha 2,3Gal linkages (where SA represents sialic acid), respectively, on cell-surface sialyloligosaccharides. Previously, we have demonstrated selection of SA alpha 2,3Gal-specific receptor variants of several human viruses which differed from the parent viruses by a single amino acid at residue 226 of the hemagglutinin which is located in the receptor binding pocket (Rogers, G. N., Paulson, J.C., Daniels, R.S., Skehel, J.J., Wilson, I.A., and Wiley, D.C. (1983) Nature 304, 76-78). In this report, the selection in the reverse direction was accomplished starting with a SA alpha 2,3Gal-specific avian virus, A/duck/Ukraine/1/63 (H3N7), yielding SA alpha 2,6Gal-specific variants that exhibit the receptor binding properties characteristic of the human isolates. Selection was again mediated at residue 226 of the hemagglutinin, in this case changing from Gln in the parent virus to Leu in the variants. Although the SA alpha 2,6Gal-specific avian virus variants were stable to passage in MDCK cells, they exhibited dramatic reversion to the SA alpha 2,3Gal-specific phenotype of the parent virus during a single passage in chicken embryos. This was in contrast to the SA alpha 2,6Gal-specific human virus isolates which were stable to passage in both hosts. The reversion of the avian virus variants in eggs provides compelling evidence for host-mediated selection of influenza virus receptor variants.
Minimally Cationic Cell-Permeable Miniature Proteins via α-Helical Arginine Display (2008)

Protein therapeutics are a blossoming industry, with revenues exceeding $51 billion in 2005 and a growth rate nearly three times that of the overall pharmaceutical industry. Although it has been known for decades that cationic polymers can transport molecular cargos across the plasma membrane, inefficient cellular delivery continues to impede the development of protein drugs. Our lab recently reported that small, folded proteins containing a minimal cationic motif embedded within a type II polyproline (PPII) helix efficiently cross the plasma membrane of eukaryotic cells. Here we demonstrate that an even smaller cationic motif can be embedded within the α-helix of a small, folded protein to generate molecules that penetrate cells significantly more efficiently than arginine-rich sequences or Tat. Our results suggest that the function of cell permeability can be encoded by judicious placement of as few as 2−3 additional arginine residues on a protein α-helix.
Autofocus by deep reinforcement learning (2019)

In recent years, smartphones have become the primary device for day-to-day photography. Therefore, it is critical for mobile imaging to capture sharp images automatically without human intervention. In this paper, we formulate autofocus as a decisionmaking process, in which the travel distance of a lens is determined from the phase data obtained from the phase sensors of a smartphone, and the decision-making policy is based on reinforcement learning, a popular technique in the field of deep learning. We propose to use a noise-tolerant reward function to combat the noise of the phase data. In addition, instead of using only the current phase data, each lens movement is determined using the phase data acquired along the journey of an autofocus process. As a result, the proposed machine-learning approach is able to expedite the autofocus process as well. Experimental results show that the method indeed improves the autofocus speed.
Elevated expression of cancer‐associated proliferating cell nuclear antigen in high‐grade prostatic intraepithelial neoplasia and prostate cancer (2010)

Our data indicate that increased expression of the cancer-associated isoform of PCNA is common in prostatic adenocarcinoma and its precursor and may be a useful biomarker.
Acute Lymphoblastic Leukemia-associated JAK1 Mutants Activate the Janus Kinase/STAT Pathway via Interleukin-9 Receptor α Homodimers (2009)

Activating mutations in JAK1 have been reported in acute lymphoblastic leukemias, but little is known about the mechanisms involved in their constitutive activation. Here, we studied the ability of JAK1 V658F and A634D to activate the Janus kinase (JAK)/STAT pathway upon ectopic expression in HEK293 cells alone or together with the other components of the interleukin-9 receptor complex (IL-9Ralpha, gammac, and JAK3). Expression of JAK1 mutants alone failed to trigger STAT activation, but co-expression of the IL-9Ralpha chain promoted JAK1 mutant phosphorylation and STAT activation. Mutation of the FERM domain of JAK1, which is critical for cytokine receptor association, or of the single tyrosine of IL-9Ralpha involved in STAT recruitment abolished this activity, indicating that JAK1 mutants need to associate with a functional IL-9Ralpha to activate STAT factors. Several lines of evidence indicated that IL-9Ralpha homodimerization was involved in this process. IL-9Ralpha variants with mutations of the JAK-interacting BOX1 region not only failed to promote JAK1 activation but also acted as dominant negative forms reverting the effect of wild-type IL-9Ralpha. Coimmunoprecipitation experiments also showed the formation of IL-9Ralpha homodimers. Interestingly, STAT activation was partially inhibited by expression of gammac, suggesting that overlapping residues are involved in IL-9Ralpha homodimerization and IL-9Ralpha/gammac heterodimerization. Co-expression of wild-type JAK3 partially reverted the inhibition by gammac, indicating that JAK3 cooperates with JAK1 mutants within the IL-9 receptor complex. Similar results were observed with IL-2Rbeta. Taken together, our results show that IL-9Ralpha and IL-2Rbeta homodimers efficiently mediate constitutive activation of ALL-associated JAK1 mutants.
Increased levels of sigJ mRNA in late stationary phase cultures of Mycobacterium tuberculosis detected by DNA array hybridisation (2001)

In order to determine which genes are involved in maintaining viability of 100-day stationary-phase bacteria and persistent bacteria after antibiotic treatment, we used a mini-DNA array to examine the transcription of 82 genes of M. tuberculosis in the 100-day stationary-phase cultures before and after rifampicin treatment. We found that the mRNA level of a sigma factor gene, sigJ, was strongly up-regulated in the late stationary-phase cultures. Other genes were also up-regulated, although to a lesser extent than sigJ. Surprisingly, after rifampicin treatment there was no significant change in sigJ expression, and most of the other 82 genes in the mini-DNA array also maintained expression, some at relatively high levels. These results suggest that SigJ may control gene expression in the quiescent state and may be an important component in the mechanisms by which M. tuberculosis survives prolonged stationary phase even in the presence of sterilising antibiotics.