gebhart/patrepeval huggingface dataset:
A comparison of laser-induced retinal damage from infrared wavelengths to that from visible wavelengths (1997)

Corneal, lenticular, and retinal damage have been observed following exposures to a laser emitting in the near-infrared wavelength range (Nd:Y AG, 1.318 ~m). Ocular damage thresholds are much higher than for visible wavelengths. However, it was found that infrared (IR) exposures may result in multiple damage sites throughout the ocular medium and retina; that exposure sites which initially appear to be unaffected may reveal slowly developing (days or longer) degeneration; and that late inflammatory responses may ultimately spread to areas of tissue not directly irradiated by the laser. The nature of tissue degeneration following IR laser exposure is examined and compared to that following visible wavelength laser exposures using three approaches: histopathology, scanning laser ophthalmoscopy, and optical coherence tomography. Each approach is shown to reveal unique aspects of the IR laser-tissue interaction when contrasted with effects induced by visible wavelengths.
Malate Plays a Crucial Role in Starch Metabolism, Ripening, and Soluble Solid Content of Tomato Fruit and Affects Postharvest Softening   (2011)

Despite the fact that the organic acid content of a fruit is regarded as one of its most commercially important quality traits when assessed by the consumer, relatively little is known concerning the physiological importance of organic acid metabolism for the fruit itself. Here, we evaluate the effect of modifying malate metabolism in a fruit-specific manner, by reduction of the activities of either mitochondrial malate dehydrogenase or fumarase, via targeted antisense approaches in tomato (Solanum lycopersicum). While these genetic perturbations had relatively little effect on the total fruit yield, they had dramatic consequences for fruit metabolism, as well as unanticipated changes in postharvest shelf life and susceptibility to bacterial infection. Detailed characterization suggested that the rate of ripening was essentially unaltered but that lines containing higher malate were characterized by lower levels of transitory starch and a lower soluble sugars content at harvest, whereas those with lower malate contained higher levels of these carbohydrates. Analysis of the activation state of ADP-glucose pyrophosphorylase revealed that it correlated with the accumulation of transitory starch. Taken together with the altered activation state of the plastidial malate dehydrogenase and the modified pigment biosynthesis of the transgenic lines, these results suggest that the phenotypes are due to an altered cellular redox status. The combined data reveal the importance of malate metabolism in tomato fruit metabolism and development and confirm the importance of transitory starch in the determination of agronomic yield in this species.
Evaluation of a Cationic Poly(β-hydroxyalkanoate) as a Plasmid DNA Delivery System (2009)

Poly(β-hydroxyalkanoates) (PHAs) are biodegradable polymers produced by a wide range of bacteria. The structures of these polymers may be tuned by controlling the available carbon source composition, but the range of functional groups accessible in this manner is limited to those that the organism is able to metabolize. Much effort has been made to chemically modify the side chains of these polymers to achieve new materials with new applications. We have previously reported the synthesis of the first cationic PHA, poly(β-hydroxyoctanoate)-co-(β-hydroxy-11-(bis(2-hydroxyethyl)-amino)-10-hydroxyundecanoate) (PHON). Here, we report the use of this polymer as a plasmid DNA delivery system. PHON was found to bind and condense the DNA into positively charged particles smaller than 200 nm. In this manner, PHON was shown to protect plasmid DNA from nuclease degradation for up to 30 min. In addition, treatment of mammalian cells in vitro with PHON/DNA complexes resulted in luciferase expression as the result of the delivery of the encoded gene.
13  μm InAs/GaAs quantum dot lasers on silicon with GaInP upper cladding layers (2018)

We report on the first electrically pumped continuous-wave (CW) InAs/GaAs quantum dot (QD) laser grown on Si with a GaInP upper cladding layer. A QD laser structure with a Ga0.51In0.49P upper cladding layer and an Al0.53Ga0.47As lower cladding layer was directly grown on Si by metal–organic chemical vapor deposition. It demonstrates the postgrowth annealing effect on the QDs was relieved enough with the GaInP upper cladding layer grown at a low temperature of 550°C. Broad-stripe edge-emitting lasers with 2-mm cavity length and 15-μm stripe width were fabricated and characterized. Under CW operation, room-temperature lasing at ∼1.3  μm has been achieved with a threshold density of 737  A/cm2 and a single-facet output power of 21.8 mW.
Hypoxia May Increase Rat Insulin mRNA Levels by Promoting Binding of the Polypyrimidine Tract-binding Protein (PTB) to the Pyrimidine-rich Insulin mRNA 3′-Untranslated Region (2002)

The complete understanding of different diabetic conditions requires the elucidation of mechanisms that control insulin gene expression. Our data show that hypoxia may increase insulin mRNA levels by promoting the binding of PTB to the insulin mRNA 3'-UTR. Hydrogen peroxide abolishes the hypoxic effect indicating involvement of reactive oxygen species and/or the redox potential in the oxygen-signaling pathway.
Aromatic nucleophilic substitution. 12. Electronic structures of 1,1-disubstituted 2-X-4-Y-naphthalene Meisenheimer complexes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAromatic nucleophilic substitution. 12. Electronic structures of 1,1-disubstituted 2-X-4-Y-naphthalene Meisenheimer complexesShizen Sekiguchi, Tetsuo Hirose, Kinzo Tsutsumi, Toshiaki Aizawa, and Haruo ShizukaCite this: J. Org. Chem. 1979, 44, 22, 3921–3925Publication Date (Print):October 1, 1979Publication History Published online1 May 2002Published inissue 1 October 1979https://pubs.acs.org/doi/10.1021/jo01336a033https://doi.org/10.1021/jo01336a033research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Contribution of P‐glycoprotein to bunitrolol efflux across blood–brain barrier (1999)

In this study, we investigated the mechanism of the blood–brain barrier (BBB) transport of bunitrolol (BTL), as a model of β-blocker, in vivo and in vitro. In order to define the contribution of P-glycoprotein (P-gp) to the active efflux of BTL from brain to blood, we examined the in vivo brain distribution of BTL in mdr1a(−/−) mice with a disrupted mdr1a gene. After intravenous administration of BTL to mdr1a(−/−) mice, the brain concentration and Kp value of BTL were significantly increased as compared with those in mdr1a(+/+) mice. Next, the contribution of the mdr1a P-gp to in vitro uptake of BTL was compared in LV500 cells and L cells (mouse mdr1a-expressing cells and host cells, respectively). The intracellular accumulations of [3H]vinblastine and BTL by LV500 cells were lower than those by L cells, but were significantly increased by verapamil, a P-gp inhibitor. Furthermore, the BTL uptake by KB-VJ300 cells, which express human P-gp, was also significantly lower than that by KB host cells, and was increased by verapamil. The steady-state uptake of BTL by LLC-GA5-COL300 cells, expressing human P-gp, was significantly increased in the presence of 20 μM cyclosporin A (another P-gp inhibitor), which had no effect in the LLC-PK1 host cells. On the other hand, the steady-state intracellular accumulation of BTL by MBEC4 cells, which express mdr1b P-gp instead of mdr1a P-gp, was not significantly changed in the presence of verapamil. This finding suggested that BTL is not a good substrate for mdr1b P-gp. In conclusion, our results suggest that BTL is transported from brain to blood by mdr1a P-gp in mice and by MDR1 in humans, and this presumably accounts for the low brain distribution of BTL. Copyright © 1999 John Wiley & Sons, Ltd.
Human Umbilical Cord Matrix Stem Cells: Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson's Disease (2005)

The umbilical cord contains an inexhaustible, noncontroversial source of stem cells for therapy. In the U.S., stem cells found in the umbilical cord are routinely placed into bio-hazardous waste after birth. Here, stem cells derived from human umbilical cord Wharton's Jelly, called umbilical cord matrix stem (UCMS) cells, are characterized. UCMS cells have several properties that make them of interest as a source of cells for therapeutic use. For example, they 1) can be isolated in large numbers, 2) are negative for CD34 and CD45, 3) grow robustly and can be frozen/thawed, 4) can be clonally expanded, and 5) can easily be engineered to express exogenous proteins. UCMS cells have genetic and surface markers of mesenchymal stem cells (positive for CD10, CD13, CD29, CD44, and CD90 and negative for CD14, CD33, CD56, CD31, CD34, CD45, and HLA-DR) and appear to be stable in terms of their surface marker expression in early passage (passages 4-8). Unlike traditional mesenchymal stem cells derived from adult bone marrow stromal cells, small populations of UCMS cells express endoglin (SH2, CD105) and CD49e at passage 8. UCMS cells express growth factors and angiogenic factors, suggesting that they may be used to treat neurodegenerative disease. To test the therapeutic value of UCMS cells, undifferentiated human UCMS cells were transplanted into the brains of hemiparkinsonian rats that were not immune-suppressed. UCMS cells ameliorated apomorphine-induced rotations in the pilot test. UCMS cells transplanted into normal rats did not produce brain tumors, rotational behavior, or a frank host immune rejection response. In summary, the umbilical cord matrix appears to be a rich, noncontroversial, and inexhaustible source of primitive mesenchymal stem cells.
Effect of recombinant granulocyte colony-stimulating factor on neutrophil kinetics in normal young and elderly humans (1996)

Abstract Recombinant granulocyte colony-stimulating factor (G-CSF) was administered to healthy young (n = 32) and elderly (n = 19) volunteers (0 microgram/d, 30 microgram/d, or 300 microgram/d) to determine its effect on neutrophil production, blood kinetics, and tissue migration. Measurements included blood counts (daily), marrow neutrophil pool sizes and neutrophil tissue migration (baseline and day 5), blood kinetics (day 6), and marrow transit time while on drug (days 6 to 14). G-CSF markedly expanded the marrow neutrophil mitotic pool and shortened the transit time of the postmitotic pool (control, mean = 6.4 days; 300 microgram/d, mean = 2.9 d). G-CSF increased neutrophil production without significantly altering blood neutrophil half-life or margination. Compared to control, neutrophil accumulation in skin chambers decreased by about 50% in the 300 microgram/d group in both young and elderly subjects. G-CSF induced neutrophilia by stimulating proliferation of marrow neutrophil precursors and accelerating neutrophil entry into the blood. Decreased neutrophil inflammatory responses measured with the skin chamber technique may be because of the relative immaturity of the circulating cells or to alterations in neutrophil phenotype induced by G-CSF.
SERAPHIN haemodynamic substudy: the effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertension (2017)

For all treatment groups, baseline and month 6 values of CI, RAP, and NT-proBNP, but not their changes, were associated with morbidity/mortality events, confirming their relevance in predicting disease progression in patients with PAH. By improving those parameters, macitentan increased the likelihood of reaching threshold values associated with lower risk of morbidity/mortality.
Strong optical injection-locked semiconductor lasers demonstrating &gt; 100-GHz resonance frequencies and 80-GHz intrinsic bandwidths (2008)

By using strong optical injection locking, we report resonance frequency enhancement in excess of 100 GHz in semiconductor lasers. We demonstrate this enhancement in both distributed feedback (DFB) lasers and vertical-cavity surface-emitting lasers (VCSELs), showing the broad applicability of the technique and that the coupling Q is the figure-of-merit for resonance frequency enhancement. We have also identified the key factors that cause low-frequency roll-off in injection-locked lasers. By increasing the slave laser's DC current bias, we have achieved a record intrinsic 3-dB bandwidth of 80 GHz in VCSELs.
Sequence-based acoustic noise reduction of clinical MRI scans (2014)

A physical sound pressure reduction of 81% (TSE) and 86% (GRE) for MRI patients was achieved. The results can be used to render MRI scans more patient-friendly in clinical practice, particularly for patients who are young, scared, or elderly.
<b>Rates of Reaction of Nitrogen Bases with Sugars. I. Studies of Aldose Oxime, Semicarbazone and Hydrazone Formation</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRates of Reaction of Nitrogen Bases with Sugars. I. Studies of Aldose Oxime, Semicarbazone and Hydrazone FormationJohn W. Haas and Raymond E. KadunceCite this: J. Am. Chem. Soc. 1962, 84, 24, 4910–4913Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/ja00883a056https://doi.org/10.1021/ja00883a056research-articleACS PublicationsRequest reuse permissionsArticle Views385Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prediction of Glass Transition Temperatures from Monomer and Repeat Unit Structure Using Computational Neural Networks (2002)

Quantitative structure-property relationships (QSPR) are developed to correlate glass transition temperatures and chemical structure. Both monomer and repeat unit structures are used to build several QSPR models for Parts 1 and 2 of this study, respectively. Models are developed using numerical descriptors, which encode important information about chemical structure (topological, electronic, and geometric). Multiple linear regression analysis (MLRA) and computational neural networks (CNNs) are used to generate the models after descriptor generation. Optimization routines (simulated annealing and genetic algorithm) are utilized to find information-rich subsets of descriptors for prediction. A 10-descriptor CNN model was found to be optimal in predicting T(g) values using the monomer structure (Part 1) for 165 polymers. A committee of 10 CNNs produced a training set rms error of 10.1K (r2 = 0.98) and a prediction set rms error of 21.7 K (r2 = 0.92). An 11-descriptor CNN model was developed for 251 polymers using the repeat unit structure (Part 2). A committee of CNNs produced a training set rms error of 21.1K (r2 = 0.96) and a prediction set rms error of 21.9 K (r2 = 0.96).
Trellis-Based Extended Min-Sum Algorithm for Non-Binary LDPC Codes and its Hardware Structure (2013)

In this paper, we present an improvement and a new implementation of a simplified decoding algorithm for non-binary low density parity-check codes (NB-LDPC) in Galois fields GF(q). The base algorithm that we use is the Extended Min-Sum (EMS) algorithm, which has been widely studied in the recent literature, and has been shown to approach the performance of the belief propagation (BP) algorithm, with limited complexity. In our work, we propose a new way to compute modified configuration sets, using a trellis representation of incoming messages to check nodes. We call our modification of the EMS algorithm trellis-EMS (T-EMS). In the T-EMS, the algorithm operates directly on the deviation space by considering a trellis built from differential messages, which serves as a new reliability measure to sort the configurations. We show that this new trellis representation reduces the computational complexity, without any performance degradation. In addition, we show that our modifications of the algorithm allows to greatly reduce the decoding latency, by using a larger degree of hardware parallelization.
Efficient personalized mispronunciation detection of Taiwanese-accented English speech based on unsupervised model adaptation and dynamic sentence selection (2012)

This study presents an efficient approach to personalized mispronunciation detection of Taiwanese-accented English. The main goal of this study was to detect frequently occurring mispronunciation patterns of Taiwanese-accented English instead of scoring English pronunciations directly. The proposed approach quickly identifies personalized mispronunciations of students, enabling English teachers to spend more time on teaching or rectifying student pronunciations. In this approach, an unsupervised model adaptation method was performed on the universal acoustic models to recognize the speech of a specific speaker with mispronunciations and a Taiwanese accent. A dynamic sentence selection algorithm that considers the mutual information of the related mispronunciations is proposed to select a sentence containing the most undetected mispronunciations to quickly detect personalized mispronunciations. The experimental results show that the proposed unsupervised adaptation approach obtains an accuracy improvement of approximately 2.1% in the recognition of Taiwanese-accented English speech.
Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine (2002)

Long-term ulcerative colitis (UC) patients are at increased risk for developing colorectal cancer. In order to develop strategies for preventing UC-associated carcinogenesis, we studied the effect of the antioxidant N-acetylcysteine (NAC) on UC-associated cancer development in a mouse model. Female C57BL/6J mice were subjected to long-term administration of dextran sulfate sodium (DSS) in the drinking fluid and 2-fold iron-enriched AIN76A diet, with or without NAC. In the DSS-plus-2-fold iron positive control group, gross tumor incidence was 88.5% (23/26 mice) after 12 DSS cycles (1 DSS cycle = 7 day DSS treatment period followed by 10 day recovery period). The tumor multiplicity was 2.1 +/- 0.2 tumors/tumor-bearing mouse, and the tumor volume was 0.054 +/- 0.019 cm3. With 0.2% NAC administration, tumor incidence was significantly reduced (68%, 17/25 mice; P < 0.05), as was the tumor multiplicity (1.5 +/- 0.1 tumors/tumor-bearing mouse; P < 0.05). The tumor volume was lower (0.014 +/- 0.004 cm3), but not significantly decreased. The proliferation index was significantly decreased in non-cancerous epithelia (48.5 +/- 6.0% vs 32.0 +/- 3.7%; P < 0.05), but not in tumor cells. NAC significantly induced apoptosis in both non-cancerous epithelia and colorectal adenocarcinoma. The number of cells immunostained-positive for nitrotyrosine was markedly decreased in the non-cancerous mucosa of NAC-treated mice (102.4 +/-16.6 positive cells/mm2 mucosa vs 53.6 +/- 14.9 cells/mm2; P < 0.05). In addition, the number of inducible nitric oxide synthase (iNOS)-positive inflammatory cells in the non-cancerous mucosa of the distal colon was markedly decreased by NAC. This study indicates that the antioxidant NAC has the potential to serve as a preventive agent for UC-associated colorectal cancer, possibly via inhibition of cellular proliferation and nitrosative stress-caused cellular damage.
Pattern formation by local self-activation and lateral inhibition (2000)

In 1972, we proposed a theory of biological pattern formation in which concentration maxima of pattern forming substances are generated through local self-enhancement in conjunction with long range inhibition. Since then, much evidence in various developmental systems has confirmed the importance of autocatalytic feedback loops combined with inhibitory interaction. Examples are found in the formation of embryonal organizing regions, in segmentation, in the polarization of individual cells, and in gene activation. By computer simulations, we have shown that the theory accounts for much of the regulatory phenomena observed, including signalling to regenerate removed parts. These self-regulatory features contribute to making development robust and error-tolerant. Furthermore, the resulting pattern is, to a large extent, independent of the details provided by initial conditions and inducing signals.