gebhart/patrepeval huggingface dataset:
Reservoir Compartmentalization Assessed With Fluid Compositional Data (1994)

Summary Fluid composition is a valuable addition to the battery of "static" data available during reservoir appraisal that can be used to predict the dynamic behavior of the reservoir later in field life. This is because fluid data are not truly static; natural fluid mixing is a dynamic process that occurs over a long (geologic) time scale. Oil compositional differences, especially those that parallel changes in density, should be mixed rapidly by convection; their preservation indicates barriers to fluid flow. Water variations, now measurable on conventional core samples by use of residual salt analysis (RSA), help identify barriers to vertical fluid flow in oil and water legs.
Tamoxifen and trifluoroperazine (Stelazine) potentiate cytostatic/cytotoxic effects of P‐30 protein, a novel protein possessing anti‐tumour activity (1990)

P-30 protein, a novel protein isolated in our laboratory from fertilized Rana pipiens eggs, has been shown to possess significant anti-proliferative and cytotoxic activity against a variety of human tumour cell lines. This protein also shows a potent anti-tumour activity in vivo in animal tumour models and is currently undergoing Phase I human clinical trials in cancer patient volunteers. The present study describes the in vitro effects of the concerted action of this protein and two other agents which affect the cell proliferative cycle. A significant potentiation of the P-30 protein-induced cell growth inhibition by tamoxifen as well as trifluoroperazine (Stelazine) in both the human A-549 lung carcinoma and the ASPC-1 pancreatic adenocarcinoma systems at wide ranges of drug concentrations was observed. The effect was apparently due to the synergistic action of P-30 protein and the agents tested. This data may provide clues that can be useful in explaining the mechanism of its anti-tumour activity. The results are also helpful for the designing in vivo animal and, perhaps eventually, human studies, whereby the combination therapies utilizing P-30 protein with agents of relatively low toxicity such as tamoxifen and/or Stelazine could offer a promising treatment(s) for these notoriously refractory types of human cancer.
1 M-cell 6b/cell analog flash memory for digital storage (2002)

This standard flash-EEPROM contains 1 M cells with multi-level programming of up to 64 digital levels per cell, providing a prototype of a 6 Mb memory with 257 Mb/cm/sup 2/ array density.
Propulsive Small Expendable Deployer System (ProSEDS) space experiment (1998)

The Propulsive Small Expendable Deployer System (ProSEDS) space experiment will demonstrate the use of an electrodynamic tether propulsion system. The flight experiment is a precursor to the more ambitious electrodynamic tether upper stage demonstration mission which will be capable of orbit raising, lowering and inclination changes-all using electrodynamic thrust. ProSEDS which is planned to fly in 2000, will use the flight proven Small Expendable Deployer System (SEDS) to deploy a tether (5km bare wire plus 15 km spectra) from a Delta II upper stage to achieve approximately 0.4N drag thrust, thus demonstrating deorbit thrust. The experiment will use a predominantly 'bare' tether for current collection in lieu of endmass collector and insulated tether approach used on previous missions. ProSEDS will utilize tether-generated current to provide limited spacecraft power. In addition to the use of this technology to provide orbit transfer of payloads and upper stages from LEO to higher orbits it may also be an attractive option for future missions to Jupiter and any other planetary body with a magnetosphere.
Criteria of Grain Refinement Induced by Ultrasonic Melt Treatment of Aluminum Alloys Containing Zr and Ti (2010)

It is well known that ultrasonic melt treatment (UST) promotes grain refinement in aluminum alloys. Cavitation-aided grain refinement has been studied for many years; however, it is still not being applied commercially. The current article summarizes the results of experimental work performed on various alloying systems at different stages of solidification. The influence of UST parameters and solidification conditions on the final grain structure is analyzed. It was found that small additions of zirconium and titanium can significantly increase the efficiency of UST, under the stipulation that grain refinement is performed in the temperature range of primary solidification of Al3Zr. The possible mechanisms for this effect are discussed.
Microwave frequency comb attributed to the formation of dipoles at the surface of a semiconductor by a mode-locked ultrafast laser (2012)

The generation of terahertz radiation by focusing a mode-locked ultrafast laser on the surface of a semiconductor was demonstrated by Zhang in 1990, and others have made numerous measurements and analyses of this effect. We have measured the surge current which causes this radiation, showing that this current, and presumably the radiation, are frequency combs with harmonics at integer multiples of the pulse repetition rate of the laser. The harmonics in the current are enhanced by placing the semiconductor in a tunneling junction, where the fundamental is increased by 8 dB with a DC tunneling current of 100 pA.
Change in glycosylation of membrane glycoproteins after transfection of NIH 3T3 with human tumor DNA. (1984)

Altered glycosylation of membrane glycoproteins was demonstrated in NIH 3T3 cells transformed by transfection with DNA from human neuroblastoma and bladder carcinoma cell lines. The oncogenes of these two cell lines have been identified as N-ras and c-H-ras-1, respectively. The fucose-labeled membrane glycopeptides of transfection-induced transformants had decreased binding to concanavalin A-Sepharose when compared in dual-isotope experiments to those from NIH 3T3 cells, whereas binding to lentil lectin-Sepharose and leukoagglutinating phytohemagglutinin-agarose was increased. Binding affinities to these immobilized lectins lead to the interpretation of the results as a decrease in biantennary glycopeptides with a simultaneous increase in tri- or tetraantennary glycopeptides. Sephadex G-50 profiles also indicated a size increase of the glycopeptides of the transformants. None of these changes was growth related. This altered glycosylation, representing a heretofore unreported effect of the onc genes, may be necessary for the transformed phenotype.
Hybrid method based on topography for robust detection of iris center and eye corners (2013)

A multistage procedure to detect eye features is presented. Multiresolution and topographic classification are used to detect the iris center. The eye corner is calculated combining valley detection and eyelid curve extraction. The algorithm is tested in the BioID database and in a proprietary database containing more than 1200 images. The results show that the suggested algorithm is robust and accurate. Regarding the iris center our method obtains the best average behavior for the BioID database compared to other available algorithms. Additional contributions are that our algorithm functions in real time and does not require complex post processing stages.
Ferrocenyl containing polysilanes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFerrocenyl containing polysilanesKeith H. Pannell, James M. Rozell, and John M. ZeiglerCite this: Macromolecules 1988, 21, 1, 276–278Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ma00179a058https://doi.org/10.1021/ma00179a058research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhibition of Influenza Virus Ribonucleic Acid Polymerase by Ribavirin Triphosphate (1977)

Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosine 5'-triphosphate and guanosine 5'-triphosphate. RTP also inhibits ApG- and GpC-stimulated influenza virus ribonucleic acid polymerase. Since ribavirin is phosphorylated in the cell, the inhibition of influenza multiplication in the cell may also be caused by RTP.
Development of polyneuropathy during thalidomide therapy (1985)

Seven patients with prurigo nodularis and one with aphthous stomatitis were given 40-115 g of thalidomide for 1 to 6 years. They all developed a predominantly sensory peripheral neuropathy mainly involving the lower limbs. Five patients had an unpleasant tight feeling around the feet. Nerve conduction studies showed small sensory action potentials from the lower limbs with normal or only mild slowing of sensory conduction velocity indicating an axonal neuropathy. The dermatological disorder improved dramatically in all, but treatment had to be discontinued because of the severe side-effects. Thalidomide, if used, should be given only over a short period because of its neurotoxic effect.
High intratumoral macrophage content is an adverse prognostic feature in anaplastic large cell lymphoma (2014)

A high content of intratumoral CD68- and/or CD163-positive macrophages correlates with an adverse outcome in ALK-negative ALCL.
Regulation of DAF-2 receptor signaling by human insulin and <i>ins-1</i>, a member of the unusually large and diverse <i>C. elegans</i> insulin gene family (2001)

The activity of the DAF-2 insulin-like receptor is required for Caenorhabditis elegans reproductive growth and normal adult life span. Informatic analysis identified 37 C. elegans genes predicted to encode insulin-like peptides. Many of these genes are divergent insulin superfamily members, and many are clustered, indicating recent diversification of the family. The ins genes are primarily expressed in neurons, including sensory neurons, a subset of which are required for reproductive development. Structural predictions and likely C-peptide cleavage sites typical of mammalian insulins suggest that ins-1 is most closely related to insulin. Overexpression of ins-1, or expression of human insulin under the control of ins-1 regulatory sequences, causes partially penetrant arrest at the dauer stage and enhances dauer arrest in weak daf-2 mutants, suggesting that INS-1 and human insulin antagonize DAF-2 insulin-like signaling. A deletion of the ins-1 coding region does not enhance or suppress dauer arrest, indicating a functional redundancy among the 37 ins genes. Of five other ins genes tested, the only other one bearing a predicted C peptide also antagonizes daf-2 signaling, whereas four ins genes without a C peptide do not, indicating functional diversity within the ins family.
Transition Metal−Amine Initiators for Preparation of Well-Defined Poly(γ-benzyl <scp>l</scp>-glutamate) (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTransition Metal−Amine Initiators for Preparation of Well-Defined Poly(γ-benzyl l-glutamate)Timothy J. DemingView Author Information Materials and Chemistry Departments University of California, Santa Barbara Santa Barbara, California 93106 Cite this: J. Am. Chem. Soc. 1997, 119, 11, 2759–2760Publication Date (Web):March 19, 1997Publication History Received29 July 1996Published online19 March 1997Published inissue 1 March 1997https://pubs.acs.org/doi/10.1021/ja962625whttps://doi.org/10.1021/ja962625wrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1385Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amines,Ligands,Living polymerization,Metals,Polymerization Get e-Alerts
Effect of Mitomycin C on Rabbit Corneal Wound Healing after Excimer Laser Photorefractive Keratectomy (2003)

Purpose: We investigated the effect of Mitomycin C (MMC) on corneal wound healing after excimer laser photorefractive keratectomy (PRK) in rabbits. Methods: Excimer laser PRK was performed on 11 white rabbits. Right eyes underwent intraoperative application of 0.02% MMC (MMC group) and left eyes underwent intraoperative application of BSS (control group) for 2 minutes. Corneal opacity was described with slit-lamp biomicroscope at 1, 2, 3, and 4 weeks after PRK. Endothelial cell count and corneal thickness were measured at preoperative period and postoperative 3 weeks. Results: Subepithelial opacity was grade 2 in MMC group and control group at postoperative 1 week. Subepithelial opacity was grade 2 in 1 of 10 eyes of MMC group and was also grade 2 in 8 of 10 eyes of control group at postoperative 2 weeks. Epithelial healing was delayed in MMC group. Corneal thickness showed no relevant difference in MMC group and control group between preoperative and postoperative periods. Endothelial cell count decreased in postoperative period in MMC group while endothelial cell count showed no relevant difference in control group between preoperative and postoperative periods. Conclusions: The application of 0.02% MMC after PRY, for 2 minutes reduced corneal haze:- However, delayed healing of corneal epithelium and damage of endothelium can be induced if MMC is not washed thoroughly.
RAPD markers of Puccinia striiformis f.sp.tritici in China (2004)

Rapid identification of the races of Puccinia striiformis f．sp．tritici by molecular technique was very important to monitor and control wheat stripe rust in China．In this paper, five physiological races of Puccinia striiformis f．sp．tritici were analysed with 210 primers by RAPD technique．The special RAPD fragments of CY31, CY29, CY23 and Shuiyuan pathotype were founded successfully．The results here indicates that a molecular identification system for the races of Puccinia striiformis f．sp．tritici in China could be established through cosmically searching special RAPD fragments of different races．
Targeting tumour energy metabolism potentiates the cytotoxicity of 5-aminolevulinic acid photodynamic therapy (2013)

As 2DG and lonidamine are already used as cancer chemotherapeutic agents, our results are directly translatable to combination therapies with existing topical PDT.
Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer (2011)

Our findings reveal sets of intronic lncRNAs expressed in pancreatic tissues whose abundance is correlated to PDAC or metastasis, thus pointing to the potential relevance of this class of transcripts in biological processes related to malignant transformation and metastasis in pancreatic cancer.
Dengue viruses and mononuclear phagocytes. II. Identity of blood and tissue leukocytes supporting in vitro infection (1977)

Studies were made on the identity of human and monkey mononuclear leukocytes permissive to antibody-enhanced dengue 2 virus (D2V) infection. In cultures of peripheral blood leukocytes (PBL) inoculated immediately after separation, it was concluded that only mononuclear phagocytes support dengue infection. This is based upon observations that D2V-permissive cells were resistant to 1,200 rads, were both plastic adherent and nonadherent, were removed when passed through nylon wool columns in 10 percent fetal bovine serum or 100 percent autologous serum, and were destroyed by incubation with 100 mug/ml particulate silica. On direct immunofluorescence staining, perinuclear dengue antigen was visualized at 24 h, becoming maximal at 60 h. Antigen-containing cells had ample cytoplasm, ruffled cytoplasmic membrane, and 73 percent were actively phagocytic. As further evidence of the infection of mononuclear phagocytes, antibody-enhanced D2V replication was observed in bone marrow cultures from five of five rhesus monkeys, but not in cell cultures of spleen, thymus, or lymph nodes prepared from the same animals. It is hypothesized that dengue virus complexed with non-neutralizing antibody is internalized by immune phagocytosis in a mononuclear phagocyte with a defective virus-destroying mechanism. Dengue permissiveness may depend upon cellular immaturity since bone marrow leukocytes could be infected even when held for 4 days before infection while PBL held for this time decreased in permissiveness. In vitro antibody-dependent infection of mononuclear phagocytes should prove useful as a model for study of immunopathologic mechanisms in human dengue.
Rabies virus production in high vero cell density cultures on macroporous microcarriers (2004)

Abstract The purpose of the study was to investigate the rabies virus multiplication in Vero cell cultures performed on porous microcarriers, MCs (cellulose–Cytopore and gelatin–Cultispher G), which provide higher available surface area compared with solid (nonporous) MCs (DEAE–Cytodex 1). In a set of experiments performed at the same MC concentration (MCs per milliliter), cell densities regularly obtained in porous MC cultures were comparable, but almost twice as high as those in solid MC cultures. In addition, 41.1 ± 3.9‐, 35.2 ± 2‐, and 19.6 ± 5.8‐fold increases in cell concentration, relative to the initial cell number, along with maximum rabies virus titers of 6.3 ± 0.3 × 10 4 , 5 ± 0.1 × 10 4 , and 4.3 ± 0.2 × 10 4 FFD 50 /mL were observed in Cytopore, Cultispher G, and Cytodex 1 MC cultures, respectively. When higher concentrations of MCs were employed, lower performances of virus production and MC‐cell occupation (cells per MC or cells per square millimeter) were observed. Cell attachment to MCs was shown to be faster for Cytopore MCs and Cytodex 1 MCs than for Cultispher G MCs. Concerning the kinetics of cell multiplication on MCs, exponential cell growth, at similar specific cell growth rates, took place on Cytopore, Cultispher G, and Cytodex 1 MCs. In addition, cell densities as high as 2.1 ± 0.2 × 10 6 cells/mL on Cytopore MCs, 1.8 ± 0.1 × 10 6 cells/mL on Cultispher G MCs, and 1 ± 0.3 × 10 6 cells/mL on Cytodex 1 MCs were regularly obtained in batch cultures. Optical as well as scanning and transmission electron microscopy studies carried out to analyze MC structure, MC cell occupation, and cell permissivity to virus infection demonstrated that there was uniform cell distribution in the external and internal areas of the MCs, suggesting an efficiency of virus synthesis. Our results indicate the usefulness of these supports for rabies virus antigen production, as well as possibilities for further optimization. © 2004 Wiley Periodicals, Inc.
Two Regions of the Human Platelet F11-Receptor (F11R) Are Critical for Platelet Aggregation, Potentiation and Adhesion (2002)

The F11 receptor (F11R) was first identified on the surface of human platelets as a target for a stimulatory monoclonal antibody (M.Ab.F11) that induces secretion, followed by exposure of fibrinogen receptors and aggregation. Cloning of the gene of F11R has revealed that this protein is a cell adhesion molecule (CAM), a member of the Ig superfamily and an ortholog of the murine protein called junctional adhesion molecule (JAM). The present study has identified two domains through which M.Ab.F11 triggers a platelet response culminating with aggregation. M.Ab.F11-mediated platelet adhesion, and the potentiation of collagen and ADP-induced platelet aggregation by M.Ab.F11, were found to involve the same two domains. A F11R recombinant protein (sF11R) completely inhibited platelet aggregation, adhesion and potentiation induced by M.Ab.F11, indicative that the active conformation of the external domain of F11R is present in the soluble, secreted recombinant protein. Furthermore, a specific peptide containing the sequence of the N-terminal amino acids S-1 to C-23 of F11R, and a peptide with the sequence of K-70 to C-82 in the 1st immunoglobulin-like (Ig) fold of F11R, both inhibited M.Ab.F11-induced aggregation, adhesion and potentiation of the aggregation of human platelets. Modeling of the 3D structure of the extracellular domain of the human platelet F11R suggests that these two regions form an active site within the conformation of this CAM. The sequence of these functional domains of F11R (in the N-terminus and 1st Ig-fold) provide the basis for new drug development in the treatment of certain types of thrombocytopenia and inflammatory thrombosis.
Asymmetric Synthesis of the Four Stereoisomers of 4-Methyl-3-heptanol via Boronic Esters: Sequential Double Stereodifferentiation Leads to Very High Purity (1990)

(S,S)-Diisopropylethanediol (S) 6, (S,S)-DIPED] boronic esters 1, (S)-3, (S)-9, 11 with (dichloromethyl)lithium yield the chain extended (αR)-(α-chloroalkyl)boronic esters (S)-2, (1R,2R)-24, (1R, 2S)-24, (R)-27, respectively in ≥ 98% diastereoisomeric excess. The major (αR) isomers with Grignard reagents yield the products of displacement of chloride by alkyl (S)-3, (1R,2R)-25, (1R, 2S)-25, (S)-9. The enantiomers have been made from (R,R)-DIPED. Contrakinetic (S,S)-DIPED (αS)-(α-chloroalkyl)boronate (S)-7 has been prepared indirectly and found to undergo a different major reaction with methylmagnesium bromide which leads to B-methyl-1,4,2-dioxaborinane 10. Thus, in the two-step formation of a new chiral center, the minor isomer is twice discriminated against. The utility of this new chemistry has been demonstrated with the asymmetric synthesis of each of the four stereoisomers of 4-methyl-3-heptanol (26) in very high purity. Diastereoselectivities measured at 350: 1 to ≥ 1000: 1 per chiral center have been achieved.
Preliminary study on implantable inductive‐type sensor for continuous monitoring of intraocular pressure (2015)

The implantable inductive-type IOP sensor demonstrated wireless pressure-sensing ability and favourable biocompatibility in the rabbit eye.