gebhart/patrepeval huggingface dataset:
Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. (1993)

Scatter factor/hepatocyte growth factor (SF/HGF) has potent motogenic, mitogenic, and morphogenetic activities on epithelial cells in vitro. The cell surface receptor for this factor was recently identified: it is the product of the c-met protooncogene, a receptor-type tyrosine kinase. We report here the novel and distinct expression patterns of SF/HGF and its receptor during mouse development, which was determined by a combination of in situ hybridization and RNase protection experiments. Predominantly, we detect transcripts of c-met in epithelial cells of various developing organs, whereas the ligand is expressed in distinct mesenchymal cells in close vicinity. In addition, transient SF/HGF and c-met expression is found at certain sites of muscle formation; transient expression of the c-met gene is also detected in developing motoneurons. SF/HGF and the c-met receptor might thus play multiple developmental roles, most notably, mediate a signal given by mesenchyme and received by epithelial. Mesenchymal signals are known to govern differentiation and morphogenesis of many epithelia, but the molecular nature of the signals has remained poorly understood. Therefore, the known biological activities of SF/HGF in vitro and the embryonal expression pattern reported here indicate that this mesenchymal factor can transmit morphogenetic signals in epithelial development and suggest a molecular mechanism for mesenchymal epithelial interactions.
In Vitro Antiviral Activity of a Peptide-Nucleic Acid Solution* Against the Human immunodeficiency Virus and influenza A Virus (1991)

A peptide-nucleic acid solution which had previously been reported to show in vivo efficacy in several viral infections (i.e. influenza, hepatitis, mumps, encephalitis, etc) was tested in three independent laboratories, including the US National Institutes of Health by specific in vitro methods for HIV and Influenza A. The results of these studies demonstrated significant anti-viral activity of the peptide-nucleic acid solution against the Human Immunodeficiency Virus (HIV) and the Influenza A virus.
A New Construction of Multiple Target Sonar and Extended Costas Arrays with Perfect Correlation (Invited Paper) (2006)

Previously there were no multiple target perfect families of Costas and sonar arrays. In this paper using the Welch Costas array and some results from design theory we construct four perfect auto and cross-correlation families of sonar and of extended Costas arrays. I. INTRODUCTION Costas and sonar sequences were respectively introduced in (1) and (2) to deal with the following problem: An object is moving towards (or away) from an observer, who wants to know effectively the distance to the object and its velocity. The solution to the problem makes use of the Doppler effect, which states the following: when a signal bounces off a moving target its frequency changes in direct proportion to the velocity of the object relative to the observer. In other words, if the observer sends out a signal towards a moving target, the change between the frequency of the outgoing and that of the returning signal will allow him to determine the velocity of the target, and the time it took to make the round trip will allow him to determine the distance. In a frequency hopping radar or sonar system, the signal consists of one or more frequencies being chosen from a set {f1 ,f 2 ,...,f m} of available frequencies, for transmission at each of a set {t1 ,t 2 ,...,t n} of consecutive time intervals. For modeling purposes, it is reasonable to consider the situation in which m = n, and where
Levodopa therapy in Parkinson’s disease: influence on liquid chromatographic tandem mass spectrometric-based measurements of plasma and urinary normetanephrine, metanephrine and methoxytyramine (2013)

These data establish that although levodopa treatment confounds identification of PPGLs that produce dopamine, the therapy is not a problem for use of LC-MS/MS measurements of plasma and urinary normetanephrine and metanephrine to diagnose more commonly encountered PPGLs that produce noradrenaline or adrenaline.
Leptin regulation of the immune response and the immunodeficiency of malnutrition <sup>1</sup> (2001)

Leptin is a 16 kDa protein mainly produced by adipose tissue in proportion to adipose tissue mass. Originally thought to be a satiety factor, leptin is a pleiotropic molecule. In addition to playing a role in energy regulation, leptin also regulates endocrine and immune functions. Both the structure of leptin and that of its receptor suggest that leptin might be classified as a cytokine. The secondary structure of leptin has similarities to the long-chain helical cytokines family, which includes interleukin 6 (IL-6), IL-11, CNTF, and LIF, and the leptin receptor is homologous to the gp-130 signal-transducing subunit of the IL-6-type cytokine receptors. Leptin plays a role in innate and acquired immunity. Leptin levels increase acutely during infection and inflammation, and may represent a protective component of the host response to inflammation. More important, leptin deficiency increases susceptibility to infectious and inflammatory stimuli and is associated with dysregulation of cytokine production. Leptin deficiency also causes a defect in hematopoiesis. Leptin regulates T cells responses, polarizing Th cells toward a Th1 phenotype. Low leptin levels occurring during starvation mediate the neuroendocrine and immune dysfunction of starvation.
The 801 Minicomputer (1983)

This paper provides an overview of an experimental system developed at the IBM Thomas J. Watson Research Center. It consists of a running hardware prototype, a control program, and an optimizing compiler. The basic concepts underlying the system are discussed, as are the performance characteristics of the prototype. In particular, three principles are examined: (1) system orientation towards the pervasive use of high-level language programming and a sophisticated compiler, (2) a primitive instruction set which can be completely hard-wired, and (3) storage hierarchy and I/O organization to enable the CPU to execute an instruction at almost every cycle.
The Type I Interferon Receptor Mediates Tyrosine Phosphorylation of Insulin Receptor Substrate 2 (1996)

Binding of interferon alpha (IFN alpha) to its receptor induces activation of the Tyk-2 and Jak-1 tyrosine kinases and tyrosine phosphorylation of multiple downstream signaling elements, including the Stat components of the interferon-stimulated gene factor 3 (ISGF-3). IFN alpha also induces tyrosine phosphorylation of IRS-1, the principle substrate of the insulin receptor. In this study we demonstrate that various Type I IFNs rapidly stimulate tyrosine phosphorylation of IRS-2. This is significant since IRS-2 is the major IRS protein found in hematopoietic cells. The IFN alpha-induced phosphorylated form of IRS-2 associates with the p85 regulatory subunit of the phosphatidylinositol 3'-kinase, suggesting that this kinase participates in an IFN alpha-signaling cascade downstream of IRS-2. We also provide evidence for an interaction of IRS-2 with Tyk-2, suggesting that Tyk-2 is the kinase that phosphorylates this protein during IFN alpha stimulation. A conserved region in the pleckstrin homology domain of IRS-2 may be required for the interaction of IRS-2 with Tyk-2, as shown by the selective binding of glutathione S-transferase (GST) fusion proteins containing the IRS-2-IH1PH or IRS-1-IH1PH domains to Tyk-2 but not other Janus kinases in vitro.
Evolution of Sucrose Synthesis (2002)

Cyanobacteria and proteobacteria (purple bacteria) are the only prokaryotes known to synthesize sucrose (Suc). Suc-P synthase, Suc-phosphatase (SPP), and Suc synthase activities have previously been detected in several cyanobacteria, and genes coding for Suc-P synthase (sps) and Suc synthase (sus) have been cloned from Synechocystis sp. PCC 6803 and Anabaena (Nostoc) spp., respectively. An open reading frame in the Synechocystis genome encodes a predicted 27-kD polypeptide that shows homology to the maize (Zea mays) SPP. Heterologous expression of this putative spp gene in Escherichia coli, reported here, confirmed that this open reading frame encodes a functional SPP enzyme. The Synechocystis SPP is highly specific for Suc-6(F)-P (K(m) = 7.5 microM) and is Mg(2+) dependent (K(a) = 70 microM), with a specific activity of 46 micromol min(-1) mg(-1) protein. Like the maize SPP, the Synechocystis SPP belongs to the haloacid dehalogenase superfamily of phosphatases/hydrolases. Searches of sequenced microbial genomes revealed homologs of the Synechocystis sps gene in several other cyanobacteria (Nostoc punctiforme, Prochlorococcus marinus strains MED4 and MIT9313, and Synechococcus sp. WH8012), and in three proteobacteria (Acidithiobacillus ferrooxidans, Magnetococcus sp. MC1, and Nitrosomonas europaea). Homologs of the Synechocystis spp gene were found in Magnetococcus sp. MC1 and N. punctiforme, and of the Anabaena sus gene in N. punctiforme and N. europaea. From analysis of these sequences, it is suggested that Suc synthesis originated in the proteobacteria or a common ancestor of the proteobacteria and cyanobacteria.
Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease (1978)

Dopa-decarboxylase, acetylcholinesterase, sodium plus potassium stimulated adenosine triphosphatase (Na+ + K+-ATPase), and membrane-bound protein kinase were compared in the erythrocytes of patients with Huntington's disease and normal controls. All these enzymes also exist in the basal ganglia. The Na+ +K+-ATPase level was elevated (p less than 0.05) in Huntington's disease, while no significant changes were observed in the other enzymes. This finding is consistent with the concept that Huntington's disease is associated with a general membrane abnormality.
Assessment of Carotid Plaque Stability Based on the Dynamic Enhancement Pattern in Plaque Components With Multidetector CT Angiography (2011)

Delayed-phase images provide information regarding the dynamic change in contrast media from the early arterial phase. An increase in HU from the early phase on multidetector CT angiography indicates plaque stability with more fibrous tissue and a less lipid-rich necrotic core, intraplaque hemorrhage, and neovascularization.
Ultrahigh-Throughput Improvement and Discovery of Enzymes Using Droplet-Based Microfluidic Screening (2017)

Enzymes are extremely valuable tools for industrial, environmental, and biotechnological applications and there is a constant need for improving existing biological catalysts and for discovering new ones. Screening microbe or gene libraries is an efficient way of identifying new enzymes. In this view, droplet-based microfluidics appears to be one of the most powerful approaches as it allows inexpensive screenings in well-controlled conditions and an ultrahigh-throughput regime. This review aims to introduce the main microfluidic devices and concepts to be considered for such screening before presenting and discussing the latest successful applications of the technology for enzyme discovery.
A Diffusion Controlled Drug Delivery System for Theophylline (1994)

The goal of achieving ideal attributes of a drug delivery system including reliability and predictability has led investigators to design controlled release (CR) systems based on the principles of microporous coatings, diffusion controlled coatings and various hydrogel type systems.In this study, the critical role of “water content fraction” of a polymer in deciding its diffusion characteristics has been ascertained and the correlation between molecular size/shape, membrane thickness, pore radii and drug diffusion has also been demonstrated. The theoretical considerations, designing and engineering of a “barrier coated-reservoir” type of a delivery system for theophylline using poly (vinyl alcohol) [PVA] as the coating material are discussed. After realizing the desired theoretical in-vitro release profile, in-vivo studies were carried out on a dog model. The potential of poly (vinyl alcohol) as a barrier coating material in developing a CR system is interestingly observed.
Hybrid TDMA/CSMA protocol for self managing packet radio networks (2002)

This paper details work on a hybrid channel access protocol being undertaken at DRA Malvern. The protocol is based on both carrier sense multiple access and adaptive reservation time division multiple access channel access protocols. It is to be implemented on a packet radio demonstrator system currently employing a contention based CSMA protocol to access a single 25 kHz VHF channel. At high traffic loadings, system performance degrades due to an increase in clashes as more stations try to access the channel. The implementation of a protocol based on a time slot principle with the addition of carrier sensing within unused slots is shown to increase the channel efficiency under all traffic loading conditions and thus improve overall system performance.
Whole Blood Thrombin: Development of a Process for Intra-Operative Production of Human Thrombin (2007)

Thrombin-based clotting agents currently used for topical hemostasis with absorbable sponges, fibrin sealants, and platelet gels are primarily derived from bovine or pooled human plasma sources. Autologous thrombin has important safety advantages in that it does not carry the same safety concerns as pooled plasma-derived products and it avoids exposure to risks associated with bovine-derived proteins. The goal of our research was to develop a rapid, reliable, and simple to perform process to generate autologous human thrombin in the intraoperative setting, from patient whole blood as the starting source material. Using whole blood instead of plasma as the starting material, it is possible to avoid the inherent delay in thrombin availability associated with a primary step of plasma isolation. In this study, we varied several key processing parameters to maximize thrombin production, reproducibility and stability. Autologous thrombin production was generated using a dedicated, single use disposable with a sterile reagent. The disposable consists of a tubular reaction chamber containing glass microsphere beads to activate the alternative pathway of the coagulation cascade. At the end of the process, thrombin-activated serum was harvested from the reaction chamber. The average activity of the thrombin produced at room temperature by this system was 82.8 +/- 15.9 IU/mL. The total processing time was < 30 minutes. The system was compatible with Anticoagulant Citrate Dextrose-Solution A (ACD-A) (8%-12%). The average volume of thrombin harvested from each aliquot of blood was 7.0 +/- 0.3 mL, and the stability of thrombin was observed to be temperature dependent, with cold storage better preserving thrombin activity. Clot times with platelet concentrates at 1:4.3 and 1:11 ratios (thrombin to platelet concentrate) were < 10 and 20 seconds, respectively. A process for the preparation of thrombin from whole blood, under conditions compatible with the resources of an operating room, has been developed. The device is simple to use, requires 30 minutes, and can consistently produce thrombin solutions that achieve rapid clotting of platelet concentrates, plasma, and fibrinogen concentrates even when mixed at thrombin to blood product ratios of 1:11.
New Phosphate Binding Agents (1999)

Several prior studies suggest that ferric compounds bind dietary phosphate and possess clinical potential as phosphate binding agents. Therefore, this study was conducted to measure the effect of several ferric compounds on intestinal phosphate binding and absorption. Balance studies lasting 2 to 4 wk were performed in normal and azotemic (achieved by subtotal nephrectomy) rats maintained on a 1.02% phosphorus diet supplemented with ferric salts (formulated to 0.95% Fe) or no ferric salt (control). In rats with normal renal function (average creatinine clearance, 4.0 ml/min per kg), the average net intestinal absorption of phosphate over all balance periods was 103.3 mg/d for the control group versus 84.7 mg/d for the ferric citrate group (P < 0.005). In the azotemic rats (average creatinine clearance, 3.3 ml/min per kg), the average net intestinal absorption of phosphate over all balance periods was significantly lower for the three ferric groups than the control groups (P < or = 0.02): 95.3 mg/d for the control group versus 75.6 mg/d for the ferric ammonium citrate-treated group (P = 0.058), 77.0 mg/d for the ferric citrate-treated group (P = 0.057), and 62.5 mg/d for the ferric chloride-treated group (P < 0.002). Urinary phosphate excretion fell, sometimes to an even greater extent than did intestinal absorption, yielding no net reduction in phosphate balance in these growing, young animals with relatively preserved renal function. Calcium balance was largely unaffected by the ferric compounds. There were trends toward decreased serum phosphorus and parathyroid hormone concentrations and increased iron and hematocrit in the ferric-treated azotemic groups. All tested ferric compounds were well tolerated, but animal growth was stunted in the ferric chloride animals compared with the control group. Phosphate binding was estimated at 85 to 180 mg per gram of elemental iron, which is comparable to other phosphate binding agents. Ferric salts decrease net intestinal phosphate absorption and hold promise for the treatment of phosphate retention in patients with renal failure.
Drought tolerance established by enhanced expression of the <i>CC–NBS–LRR</i> gene, <i>ADR1</i>, requires salicylic acid, EDS1 and ABI1 (2004)

An activation-tagged allele of activated disease resistance 1 (ADR1) has previously been shown to convey broad spectrum disease resistance. ADR1 was found to encode a coiled-coil (CC)-nucleotide-binding site (NBS)-leucine-rich repeat (LRR) protein, which possessed domains of homology with serine/threonine protein kinases. Here, we show that either constitutive or conditional enhanced expression of ADR1 conferred significant drought tolerance. This was not a general feature of defence-related mutants because cir (constitutive induced resistance)1, cir2 and cpr (constitutive expressor of PR genes)1, which constitutively express systemic acquired resistance (SAR), failed to exhibit this phenotype. Cross-tolerance was not a characteristic of adr1 plants, rather they showed increased sensitivity to thermal and salinity stress. Hence, adr1-activated signalling may antagonise some stress responses. Northern analysis of abiotic marker genes revealed that dehydration-responsive element (DRE)B2A but not DREB1A, RD (response to dehydration)29A or RD22 was expressed in adr1 plant lines. Furthermore, DREB2A expression was salicylic acid (SA) dependent but NPR (non-expressor of PR genes)1 independent. In adr1/ADR1 nahG (naphthalene hydroxylase G), adr1/ADR1 eds (enhanced disease susceptibility)1 and adr1/ADR1 abi1 double mutants, drought tolerance was significantly reduced. Microarray analyses of plants containing a conditional adr1 allele demonstrated that a significant number of the upregulated genes had been previously implicated in responses to dehydration. Therefore, biotic and abiotic signalling pathways may share multiple nodes and their outputs may have significant functional overlap.
Rate and buffer regulation in a video encoder for seamless splicing (2002)

An algorithm is presented for switching of compressed video streams in order to support the insertion of local programs and commercials for digital television production. This enables the creation of particular points in compressed video streams, whose characteristics allow to seamlessly switch between streams. These switching points are constructed by computing the buffer bounds in the video encoder so as to ensure that the decoder buffer does not underflow or overflow.
Ceramic Materials for Electronics (2018)

Ceramic Insulators. Highly Conductive Ceramics. Ceramic Capacitor Materials. Piezoelectric and Electro-optic Ceramics. Ferrite Ceramics. Ceramic Sensors. ZnO Varistor Technology. Electroceramic Thin Films for Microelectronics and Microsystems. Materials Aspects of Thick-Film Technology. Multilayer Ceramic Technology.
Scalable fault management for OpenFlow (2012)

In the OpenFlow based split architecture, data-plane forwarding is separated from control and management functions. Forwarding elements make only simple forwarding decisions based on flow table entries populated by the controller. While OpenFlow does not specify how topology monitoring is performed, the centralized controller can use Link-Layer Discovery Protocol (LLDP) messages to discover link and node failures and trigger restoration actions. This monitoring and recovery model has serious scalability limitations because the controller has to be involved in the processing of all of the LLDP monitoring messages. For fast recovery, monitoring messages must be sent with millisecond interval over each link in the network. This poses a significant load on the controller. In this paper we propose to implement a monitoring function on OpenFlow switches, which can emit monitoring messages without posing a processing load on the controller. We describe how the OpenFlow 1.1 protocol should be extended to support the monitoring function. Our experimental results show that data plane fault recovery can be achieved in a scalable way within 50 milliseconds using this function.
On the existence of equilibria in noncooperative optimal flow control (1995)

The existence of Nash equilibria in noncooperative flow control in a general product-form network shared by K users is investigated. The performance objective of each user is to maximize its average throughput subject to an upper bound on its average time-delay. Previous attempts to study existence of equilibria for this flow control model were not successful, partly because the time-delay constraints couple the strategy spaces of the individual users in a way that does not allow the application of standard equilibrium existence theorems from the game theory literature. To overcome this difficulty, a more general approach to study the existence of Nash equilibria for decentralized control schemes is introduced. This approach is based on directly proving the existence of a fixed point of the best reply correspondence of the underlying game. For the investigated flow control model, the best reply correspondence is shown to be a function, implicitly defined by means of K interdependent linear programs. Employing an appropriate definition for continuity of the set of optimal solutions of parameterized linear programs, it is shown that, under appropriate conditions, the best reply function is continuous. Brouwer's theorem implies, then, that the best reply function has a fixed point.
Use of bioluminescent Salmonella for assessing the efficiency of constructed phage-based biosorbent (2001)

A bacteriophage-based biosorbent for Salmonella enteritidis was constructed, and bacterial bioluminescence was used for assessment of the efficiency of cell capture. A strain of S. enteritidis with bioluminescent phenotype was constructed by transformation with plasmid pT7 carrying the entire lux operon from Photorhabdus luminescens. The relation between relative light output (RLU) and colony-forming units (CFU/ml) of the bioluminescent strain was established. The bacteriophage specific to S. enteritidis was biotinylated, and the biotinylation procedure was optimized based on the maximum retention of phage infectivity. The biotinylated phages were then coated onto streptavidin-labeled magnetic beads, and were used to capture the bioluminescent S. enteritidis cells. Our preliminary results showed that the number of cells captured by constructed biosorbent was five times higher than that of the control, magnetic beads coated with nonbiotinylated phage, indicating the capture is specific. Journal of Industrial Microbiology & Biotechnology (2001) 27, 126–128.