gebhart/patrepeval huggingface dataset:
Glycoprotein P3.58, associated with tumor progression in malignant melanoma, is a novel leukocyte activation antigen (1988)

The P3.58 antigen is defined by monoclonal antibodies (MAbs) selected to discriminate between benign and malignant melanocytic cells. Its expression in malignant cells has been shown to correlate with an increased risk of metastasis. A survey of a wide range of tissues revealed that, on normal tissue, expression of P3.58 antigen is restricted to a subset of cells involved in the immune response. The antigen was found not only on certain endothelia, but also on activated macrophages in vivo and in vitro and as well as on activated B lymphocytes. A comparison with known B-lymphocyte and leukocyte activation antigens indicated that P3.58 is a novel leukocyte activation antigen. Biochemical analysis of the P3.58 antigen isolated from cells of different histogenic origin indicated that different molecular forms of the antigen exist, apparently depending on the cell type of origin. P3.58 molecules precipitated from tunicamycin-treated cells were identical in all cell types, suggesting that the variation observed is due to variable N-glycosylation.
Experimental Study of the High Temperature Mechanical Behaviors of TLP Bonding of Two Ni-Base Single Crystals (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Metabolic Engineering of <i>Saccharomyces cerevisiae</i> for Conversion of <scp>d</scp> -Glucose to Xylitol and Other Five-Carbon Sugars and Sugar Alcohols (2007)

Recombinant Saccharomyces cerevisiae strains that produce the sugar alcohols xylitol and ribitol and the pentose sugar D-ribose from D-glucose in a single fermentation step are described. A transketolase-deficient S. cerevisiae strain accumulated D-xylulose 5-phosphate intracellularly and released ribitol and pentose sugars (D-ribose, D-ribulose, and D-xylulose) into the growth medium. Expression of the xylitol dehydrogenase-encoding gene XYL2 of Pichia stipitis in the transketolase-deficient strain resulted in an 8.5-fold enhancement of the total amount of the excreted sugar alcohols ribitol and xylitol. The additional introduction of the 2-deoxy-glucose 6-phosphate phosphatase-encoding gene DOG1 into the transketolase-deficient strain expressing the XYL2 gene resulted in a further 1.6-fold increase in ribitol production. Finally, deletion of the endogenous xylulokinase-encoding gene XKS1 was necessary to increase the amount of xylitol to 50% of the 5-carbon sugar alcohols excreted.
Development, validation, and initial results of the Angioedema Activity Score (2013)

The AAS is the first validated and reliable tool to determine disease activity in RecA patients, and it may serve as a valuable instrument in future clinical studies and routine patient care.
Mania-like behavior induced by disruption of <i>CLOCK</i> (2007)

Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be particularly important. However, the exact role of this gene in the development of this disorder remains unclear. Here we show that mice carrying a mutation in the Clock gene display an overall behavioral profile that is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower anxiety, and an increase in the reward value for cocaine, sucrose, and medial forebrain bundle stimulation. Chronic administration of the mood stabilizer lithium returns many of these behavioral responses to wild-type levels. In addition, the Clock mutant mice have an increase in dopaminergic activity in the ventral tegmental area, and their behavioral abnormalities are rescued by expressing a functional CLOCK protein via viral-mediated gene transfer specifically in the ventral tegmental area. These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood.
Implementation and application of a brain template for multiple volumes of interest (2002)

We present a region template and a protocol for transforming that template to define anatomical volumes of interest (VOIs) in the human brain without operator intervention, based on software contained in the SPM99 package (Statistical Parametric Mapping, Wellcome Department of Cognitive Neurology, London, UK). We used an MRI of a reference brain to create an anatomical template of 41 VOIs, covering the entire brain, that can be spatially transformed to fit individual brain scans. Modified software allows for the reslicing and adaptation of the transformed template to any type of coregistered functional data. Individually defined VOIs can be added. We present an assessment of the necessary spatial transformations and compare results obtained for scans acquired in two different orientations. To evaluate the spatial transformations, 11 landmarks distributed throughout the brain were chosen. Euclidean distances between repeat samples at each landmark were averaged across all landmarks to give a mean difference of 1.3 plus minus 1.0 mm. Average Euclidean distances between landmarks (MRI:transformed template) were 8.1 plus minus 3.7 mm in anterior-posterior commissure (ACPC) and 7.6 plus minus 3.7 mm in temporal lobe (TL) orientation. In this study, we use [(11)C]-flumazenil-(FMZ-)PET as an example for the application of the region template. Thirty-four healthy volunteers were scanned, 21 in standard ACPC orientation, 13 in TL orientation. All had high resolution MRI and FMZ-PET. The average coefficient of variation (CV) of FMZ binding for cortical regions was 0.15, comparable with CVs from manually defined VOIs. FMZ binding was significantly different in 6/19 anatomical areas in the control groups obtained in the different orientations, probably due to anisotropic voxel dimensions. This new template allows for the reliable and fast definition of multiple VOIs. It can be used for different imaging modalities and in different orientations. It is necessary that imaging data for groups compared are acquired in the same orientation.
Soft Error Performance of Z-RAM Floating Body Memory (2006)

The zero-capacitor (Z-RAMreg) floating body memory is a dynamic memory built on an SOI substrate. It differs from a DRAM cell in that it does not rely on an external capacitor to store charge and reading is done by sensing cell current. The Z-RAM memory cell stores charge in its floating body and uses this charge to alter the threshold voltage and gain of the cell transistor. The advantages of the Z-RAM cell are numerous and include a smaller cell size, lithographic friendly processing, fast access time, and no additional processing steps for use as an embedded memory (Okhonin et al., 2001). However, there is little published data on the soft error rates (SER) of this type of memory. This paper summarizes the results of accelerated alpha particle testing conducted on four, 1 Mbit Z-RAM test vehicles. As expected from the nature of the Z-RAM operation and its small cell size, its SER was observed to be significantly better than SRAM and comparable to the SER performance of embedded DRAM
Statistical quality control : a modern introduction (2009)

Part I: Introduction Chapter 1: Quality Improvement in the Modern Business Environment Chapter 2: The DMAIC Process Part II: Statistical Methods Useful in Quality Control and Improvement Chapter 3: Modeling Process Quality Chapter 4: Inferences about Process Quality Part III: Basic Methods of Statistical Process Control and Capability Analysis Chapter 5: Methods and Philosophy of Statistical Process Control Chapter 6: Control Charts for Variables Chapter 7: Control Charts for Attributes Chapter 8: Process and Measurement System Capability Analysis Part IV: Other Statistical Process-Monitoring and Control Techniques Chapter 9: Cumulative Sum and Exponentially Weighted Moving Average Control Charts Chapter 10: Other Univariate Statistical Process Monitoring and Control Techniques Chapter 11: Multivariate Process Monitoring and Control Chapter 12: Engineering Process Control and SPC Part V: Process Design and Improvement with Designed Experiments Chapter 13: Factorial and Fractional Experiments for Process Design and Improvements Chapter 14: Process Optimization and Designed Experiments Part VI: Acceptance Sampling Chapter 15: Lot-by-Lot Acceptance Sampling for Attributes Chapter 16: Other Acceptance Sampling Techniques Appendix
Population Pharmacokinetics of Dexmedetomidine in Infants After Open Heart Surgery (2010)

Dexmedetomidine clearance increased with weight, age, and single-ventricle physiology, whereas total bypass time was associated with a trend toward decreasing clearance, and central volume of distribution increased as a function of total bypass time. The dependence of clearance on body weight supports current practice of weight-based dexmedetomidine dosing, whereas the clinical impact of the remaining covariate effects requires further investigation. Initial loading doses in the range of 0.35 to 1 microg/kg over 10 minutes and CIVI of 0.25 to 0.75 microg/kg/h were well tolerated in this infant population.
ChemInform Abstract: Room‐Temperature Deposition of Defect‐Free Magnetic Film by Chemical Reaction from an Aqueous Solution. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hydraulic Fracture Monitoring to Reservoir Simulation: Maximizing Value (2010)

Abstract Hydraulic fracture monitoring with microseismic mapping is now routinely used to measure hydraulic fracture geometry, location, and complexity, providing an abundance of information that can be essential to optimizing stimulation treatments and well completions. Although microseismic mapping has added significant value in many different environments, we have yet to fully utilize microseismic data. Significant details can be extracted from microseismic measurements that, when integrated with other information, can improve the characterization of both the reservoir and the hydraulic fracture. In addition, microseismic data has yet to be quantitatively and routinely utilized in reservoir simulation, which is the key to optimization. Geological and geophysical data and wellbore logs can be combined with newly-developed complex fracture propagation models and reservoir simulation models. These models are calibrated using microseismic measurements and production data— closing the loop from microseismic mapping to simulation. The combination of microseismic measurements and complex fracture modeling with sophisticated geological descriptions of pre-existing natural fractures can be used to evaluate existing and predict future well performance in complex shale-gas reservoirs. The application of calibrated complex hydraulic fracture and reservoir simulation models provides more reliable forecasts of well performance resulting from various hydraulic fracture designs and completion scenarios, allowing the selection of the most economic strategy. The optimization process includes a detailed workflow to efficiently integrate the large amount of information and modeling results into a coherent work product. This includes the integration of advanced processing and geomechanical interpretations of microseismic data with newly developed complex hydraulic fracture models that significantly improve the application of microseismic measurements. An example illustrates how HFM can be taken from event locations to production forecasts, showing how the capability to integrate geophysics, geomechanics, hydraulic fracture mechanics, and reservoir simulation can result in significant economic benefits.
Target Size, Location, Sampling Point and Instructional Set: More Effects on Touch Panel Operation (1990)

Accuracy of input using touch panel devices is affected by a number of variables which include device type, target size, and target location. It was also hypothesized that instructional set should influence performance. A screening experiment using a central-composite design (CCD) was conducted to further examine the effects of target position and size upon accuracy of the touch input. Results suggest that error for right-handed users is least near the resting position of the hand (lower right corner of display) and that shortest response times could also be obtained there. Variations in size were more likely to affect error in the y axis and quadratic effects were present. It was also found that although instructions requiring higher precision of input from the operator did not substantially affect bias error, they did produce a reduction in variable error. It is recommended that for applications having established key input areas, positions along the lower and right-hand borders of the control/display unit should be used to minimize activation time and error. Use of the lower border exclusively can accomodate users with either a right-hand or left-hand preference. Some comments are also provided on the limitations which bound the interpretation of results in several studies and inferences thus drawn.
La respuesta de los bancos centrales a la crisis ha sido muy buena (2009)

Somero análisis de la crisis financiera internacional, la actuación de los bancos centrales frente a ella, la recesión que parece cernirse sobre muchas economías y los riesgos de una inflación de caracteres globales.
Regulation of T-cell Responses and Disease by Tec Kinase Itk (2012)

Itk is a member of the Tec family tyrosine kinases involved in T-cell receptor signaling. The authors review the background and most recent findings of the role of Itk T-cell activation and development of αβ T cells. They also discuss the role of Itk in development of nonconventional T cells, including CD8(+) innate memory phenotype T cells, different γδ T-cell populations, and invariant NKT cells. They close by reviewing the regulation of T helper differentiation and cytokine secretion, the immune response to infectious disease, and diseases such as allergic asthma and atopic dermatitis by Itk.
The Fibrel Mechanism of Action Study (1994)

Fibrel does promote new collagen synthesis and inflammatory response and thus is useful to correct cutaneous depressions via soft tissue augmentation.
Degradations due to hole trapping in flash memory cells (1989)

Degradation in the hot-electron programmability of the flash memory cell is observed after erasing from the drain. Trapped holes in the oxide near the drain junction are found to be responsible for this degradation. Hole trapping in the oxide also causes another problem known as gate disturb, which is the undesired increase in the threshold voltage of an erased cell during programming of the other cells on the same word line. Threshold-voltage shifts due to gate disturb are used to monitor the amount of trapped holes in the oxide after cell erasure. It is determined that the trapped holes are mainly externally injected from the junction depletion region rather than directly generated in the oxide by the Fowler-Nordheim (F-N) tunneling process.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Circulating immune complexes (CIC), carcinoembryonic antigen (CEA) and CIC containing CEA as markers for colorectal cancer. (1984)

It has been suggested that circulating immune complexes (CIC) would provide a useful tumour marker system and that carcinoembryonic antigen (CEA) may form an antigen component of CIC found in patients with colorectal cancer. In this study the clinical usefulness of CIC and CIC containing CEA (CEA-IC) was investigated. Concentrations of CIC were measured in 30 patients with colorectal cancer. Fourteen patients were studied sequentially at approximately 1 month intervals after apparent curative resection of the primary tumour. Results were correlated with those obtained from serum CEA and compared to clinical status. CEA-IC were measured using a novel assay and compared with CIC and CEA values in 29 patients. CIC concentrations were elevated in patients with known disease and predicted clinical relapse in four of 14 patients. In two patients CIC remained elevated despite sustained remission. CEA-IC were not detectable in any of the patients studied. CIC estimations may augment CEA measurements as indicators of disease recurrence but lack of specificity makes them of little practical value as tumour markers in colorectal cancer. No evidence was found to support previous reports that CEA was an antigen component of CIC in this disease.
Differential expression of a Clostridium acetobutylicum antisense RNA: implications for regulation of glutamine synthetase (1992)

The Clostridium acetobutylicum glutamine synthetase (GS) DNA region is characterized by a downstream promoter, P3, oriented toward the glnA gene, which controls the transcription of an RNA complementary to the start of the glnA mRNA. Expression of the predicted 43-base antisense RNA was demonstrated in C. acetobutylicum and Escherichia coli cells containing the cloned glnA DNA. Antisense RNA transcription from P3 was not regulated by nitrogen in E. coli cells, but the expression of antisense RNA was associated with decreased levels of GS activity. In C. acetobutylicum, GS activity and the transcription of glnA mRNA and antisense RNA were regulated by nitrogen. GS activity and glnA mRNA were repressed in cells grown in nitrogen-rich medium. Repression ratios for GS activity varied from 1.6 to 9.0, depending on the sampling time. The relative number of glnA transcripts was approximately 25% lower in cells grown for 72 h in nitrogen-rich medium than in cells grown in nitrogen-limiting medium. This finding contrasted with the expression of antisense RNA, which was repressed in nitrogen-limiting medium but induced in nitrogen-rich medium. The relative number of antisense RNA transcripts was increased approximately sixfold in cells grown in nitrogen-rich medium. There was a 1.6-fold excess of antisense RNA over glnA mRNA under conditions that repressed GS activity. Under conditions that induced GS activity, glnA mRNA transcripts exceeded antisense RNA transcripts by fivefold.
Hepatitis C virus antibodies among risk groups in a South African area endemic for hepatitis B virus (1993)

The prevalence of anti-HCV was studied in a South African area endemic for hepatitis B virus. A total of 35,685 volunteer blood donors (22,034 whites, 9,218 Asians, 3,077 Africans, 1,356 coloureds), 71 haemophiliacs, 84 chronic dialysis patients, 100 antenatal attenders, 212 nurses, and 20 HIV-positive male homosexuals were tested for anti-HCV. Repeat positive second generation Ortho HCV EIA was used to determine HCV status for the blood donors; Abbott-II HCV EIA combined with a neutralisation test was used for the other risk groups. Antibody to hepatitis B core antigen (anti-HBc) was also tested in the haemophiliacs, nurses, and chronic dialysis patients. Seroprevalence for the blood donor population was 0.16, 0.34, 0.75, and 0.22% for whites, Asians, Africans, and coloureds, respectively. Of the risk groups tested, 39.4% of haemophiliacs and 4.8% of chronic dialysis patients were positive; of the remainder tested none was positive. Fifty percent of nurses, 47.9% of haemophiliacs, and 22.6% of dialysis patients had serological evidence of past exposure to hepatitis B virus (anti-HBc positive). These findings indicate a low prevalence of anti-HCV in the blood donor population, thus probably resulting in a low prevalence in groups exposed to blood and blood derivatives. The overall difference in prevalence between the race groups was significant (P < 0.0001). The high prevalence of hepatitis B virus compared to the low prevalence of HCV suggests that the main modes of transmission of the two viruses are probably different.
A Single Residue Substitution Causes a Switch from the Dual DNA Binding Specificity of Plant Transcription Factor MYB.Ph3 to the Animal c-MYB Specificity (1997)

Transcription factor MYB.Ph3 from Petunia binds to two types of sequences, MBSI and MBSII, whereas murine c-MYB only binds to MBSI, and Am305 from Antirrhinum only binds to MBSII. DNA binding studies with hybrids of these proteins pointed to the N-terminal repeat (R2) as the most involved in determining binding to MBSI and/or MBSII, although some influence of the C-terminal repeat (R3) was also evident. Furthermore, a single residue substitution (Leu71 --> Glu) in MYB.Ph3 changed its specificity to that of c-MYB, and c-MYB with the reciprocal substitution (Glu132 --> Leu) essentially gained the MYB.Ph3 specificity. Molecular modeling and DNA binding studies with site-specific MYB.Ph3 mutants strongly supported the notion that the drastic changes in DNA binding specificity caused by the Leu --> Glu substitution reflect the fact that certain residues influence this property both directly, through base contacts, and indirectly, through interactions with other base-contacting residues, and that a single residue may establish alternative base contacts in different targets. Additionally, differential effects of mutations at non-base-contacting residues in MYB.Ph3 and c-MYB were observed, reflecting the importance of protein context on DNA binding properties of MYB proteins.
Multi-Cloud Resource Management Techniques for Cyber-Physical Systems (2021)

Information technology is based on data management between various sources. Software projects, as varied as simple applications or as complex as self-driving cars, are heavily reliant on the amounts, and types, of data ingested by one or more interconnected systems. Data is not only consumed but is transformed or mutated which requires copious amounts of computing resources. One of the most exciting areas of cyber-physical systems, autonomous vehicles, makes heavy use of deep learning and AI to mimic the highly complex actions of a human driver. Attempting to map human behavior (a large and abstract concept) requires large amounts of data, used by AIs to increase their knowledge and better attempt to solve complex problems. This paper outlines a full-fledged solution for managing resources in a multi-cloud environment. The purpose of this API is to accommodate ever-increasing resource requirements by leveraging the multi-cloud and using commercially available tools to scale resources and make systems more resilient while remaining as cloud agnostic as possible. To that effect, the work herein will consist of an architectural breakdown of the resource management API, a low-level description of the implementation and an experiment aimed at proving the feasibility, and applicability of the systems described.