gebhart/patrepeval huggingface dataset:
Profile Design Issues and Optimization of Epitaxial Si and SiGe-Base Bipolar Transistors and Circuits for 77K Applications (1991)

In this work we investigate the profile design issues associated with optimizing epitaxial Si and SiGe-base bipolar transistors and circuits for 77K applications.
Thermally Stable Polycrystalline Diamond Cutters for Drill Bits (2004)

Abstract Current research has developed an improved ENDURUSTM TSP (thermally stable polycrystalline diamond) cutter and the potential to increase rate of penetration and bit life in hard and abrasive rock. PDC (polycrystalline diamond) wear rates increase exponentially above 700 °F (372 °C), and PDC fails structurally at 1350 °F (750 °C). The ENDURUS™ cutter differ from all forms of PDC and TSP materials in that they maintain a constant wear rate up to 2192 °F (1200 °C) and are stronger to withstand drilling impact forces. TSP cutters have not generally been economic due to low ROP with small available sizes that are surface-set in drag bits, and because of insufficient attachment and impact strength in the larger self-sharpening PDC configurations. All types of commercially available TSP have insufficient fracture resistance for most applications. Low attachment strength and impact resistance is reminiscent of the limitation of PDC in the 1970&amp;#39;s before a unique LS induction brazing process was developed in the latter 1970&amp;#39;s. TSP can now be brazed with high attachment shear strength using two unique brazing methods – Microwave and Combustion Synthesis Brazing. New TSP manufacturing processes result in a 36% increase in fracture resistance and attachment shear strength over 50,000 psi. (345 MPa). TSP drill bits now have the potential to reduce well cost by 15%, and overall project cost by 7.5%. Thus, the industry could have greater economic incentive to produce deep wells.
Reduced Retinal Angiogenesis in MMP-2–Deficient Mice (2003)

MMP-2 may be essential in the regulation of retinal neovascularization. Pharmacologic intervention using MMP inhibitors may be a future therapeutic approach for angiogenic retinal diseases.
Synthesis and Structure-Activity Relationships in a Series of Antiinflammatory Corticosteroid Analogs, Halomethyl Androstane-17.beta.-carbothioates and -17.beta.-carboselenoates (1994)

The preparation and topical antiinflammatory potencies of a series of halomethyl 17 alpha-(acyloxy)- 11 beta-hydroxy-3-oxoandrosta-1,4-diene-17 beta-carbothioates, carrying combinations of 6 alpha-fluoro, 9 alpha-fluoro, 16-methyl, and 16-methylene substituents, are described. Key synthetic stages were the preparation of carbothioic acids and their reaction with dihalomethanes. The carbothioic acids were formed from 17 beta-carboxylic acids by initial reaction with dimethylthiocarbamoyl chloride followed by aminolysis of the resulting rearranged mixed anhydride with diethylamine, or by carboxyl activation with 1,1'-carbonyldiimidazole (CDI) or 2-fluoro-N-methylpyridinium tosylate (FMPT) and reaction with hydrogen sulfide, the choice of reagent being governed by the 17 alpha-substituent. Carboxyl activation with FMPT and reaction with sodium hydrogen selenide led to the halomethyl 16-methyleneandrostane-17 beta-carboselenoate analogues. Anti-inflammatory potencies were measured in humans using the vasoconstriction assay and in rats and mice by a modification the Tonelli croton oil ear assay. Best activities were shown by fluoromethyl and chloromethyl carbothioates with a 17 alpha-propionyloxy group. S-Fluoromethyl 6 alpha, 9 alpha-difluoro-11 beta-hydroxy-16 alpha-methyl-3-oxo-17 alpha- (propionyloxy)androsta-1,4-diene-17 beta-carbothioate (fluticasone propionate, FP) was selected for clinical study as it showed high topical antiinflammatory activity but caused little hypothalamic-pituitary-adrenal suppression after topical or oral administration to rodents.
Dynamic trajectory‐based couch motion for improvement of radiation therapy trajectories in cranial SRT (2015)

The authors' study indicated that simultaneous couch and gantry motion during radiation therapy to minimize the geometrical overlap in the beams-eye-view of target volumes and the organs-at-risk can have an appreciable dose reduction to organs-at-risk.
Building Predictive Models in <i>R</i> Using the <b>caret</b> Package (2008)

The caret package, short for classification and regression training, contains numerous tools for developing predictive models using the rich set of models available in R. The package focuses on simplifying model training and tuning across a wide variety of modeling techniques. It also includes methods for pre-processing training data, calculating variable importance, and model visualizations. An example from computational chemistry is used to illustrate the functionality on a real data set and to benchmark the benefits of parallel processing with several types of models.
Two Arginine Repressors Regulate Arginine Biosynthesis in<i>Lactobacillus plantarum</i> (2004)

The repression of the carAB operon encoding carbamoyl phosphate synthase leads to Lactobacillus plantarum FB331 growth inhibition in the presence of arginine. This phenotype was used in a positive screening to select spontaneous mutants deregulated in the arginine biosynthesis pathway. Fourteen mutants were genetically characterized for constitutive arginine production. Mutations were located either in one of the arginine repressor genes (argR1 or argR2) present in L. plantarum or in a putative ARG operator in the intergenic region of the bipolar carAB-argCJBDF operons involved in arginine biosynthesis. Although the presence of two ArgR regulators is commonly found in gram-positive bacteria, only single arginine repressors have so far been well studied in Escherichia coli or Bacillus subtilis. In L. plantarum, arginine repression was abolished when ArgR1 or ArgR2 was mutated in the DNA binding domain, or in the oligomerization domain or when an A123D mutation occurred in ArgR1. A123, equivalent to the conserved residue A124 in E. coli ArgR involved in arginine binding, was different in the wild-type ArgR2. Thus, corepressor binding sites may be different in ArgR1 and ArgR2, which have only 35% identical residues. Other mutants harbored wild-type argR genes, and 20 mutants have lost their ability to grow in normal air without carbon dioxide enrichment; this revealed a link between arginine biosynthesis and a still-unknown CO2-dependent metabolic pathway. In many gram-positive bacteria, the expression and interaction of different ArgR-like proteins may imply a complex regulatory network in response to environmental stimuli.
DeepFont: Identify Your Font from An Image (2015)

As font is one of the core design concepts, automatic font identification and similar font suggestion from an image or photo has been on the wish list of many designers. We study the Visual Font Recognition (VFR) problem, and advance the state-of-the-art remarkably by developing the DeepFont system. First of all, we build up the first available large-scale VFR dataset, named AdobeVFR, consisting of both labeled synthetic data and partially labeled real-world data. Next, to combat the domain mismatch between available training and testing data, we introduce a Convolutional Neural Network (CNN) decomposition approach, using a domain adaptation technique based on a Stacked Convolutional Auto-Encoder (SCAE) that exploits a large corpus of unlabeled real-world text images combined with synthetic data preprocessed in a specific way. Moreover, we study a novel learning-based model compression approach, in order to reduce the DeepFont model size without sacrificing its performance. The DeepFont system achieves an accuracy of higher than 80% (top-5) on our collected dataset, and also produces a good font similarity measure for font selection and suggestion. We also achieve around 6 times compression of the model without any visible loss of recognition accuracy.
Testing atomicity of composed concurrent operations (2011)

We address the problem of testing atomicity of composed concurrent operations. Concurrent libraries help programmers exploit parallel hardware by providing scalable concurrent operations with the illusion that each operation is executed atomically. However, client code often needs to compose atomic operations in such a way that the resulting composite operation is also atomic while preserving scalability. We present a novel technique for testing the atomicity of client code composing scalable concurrent operations. The challenge in testing this kind of client code is that a bug may occur very rarely and only on a particular interleaving with a specific thread configuration. Our technique is based on modular testing of client code in the presence of an adversarial environment; we use commutativity specifications to drastically reduce the number of executions explored to detect a bug. We implemented our approach in a tool called COLT, and evaluated its effectiveness on a range of 51 real-world concurrent Java programs. Using COLT, we found 56 atomicity violations in Apache Tomcat, Cassandra, MyFaces Trinidad, and other applications.
Mn-doped ZnS nanoparticles as efficient low-voltage cathodoluminescent phosphors (1999)

We have synthesized nanoparticles of ZnS doped with Mn for potential use as cathodoluminescent phosphors in field-emission displays (FEDs). We show that the cathodoluminescent efficiency of particles ⩽100 nm in diameter is within 40% of that of a commercial (micron-sized) phosphor when the electron-beam energy ranges between 500 and 3500 eV. The nanoparticles exhibit less current saturation than larger-sized phosphors, an important feature for use in FEDs. Furthermore, the nanoparticles were annealed at just 535 °C, hundreds of degrees below the processing temperatures of standard phosphors. Finally, we discuss the effect of the particle surface on low-voltage luminous efficiency.
Use of combined mass spectrometry methods for the characterization of a new variant of human hemoglobin: The double mutant hemoglobin villeparisis β77(EF1) His → Tyr, β 80 (EF4) Asn → Ser (1996)

Hemoglobin Villeparisis was found during a systematic measurement of glycated hemoglobin. Electrospray mass spectra of the globin indicate an apparently unchanged molecular weight within the error range (0.01%). The tryptic digest of the β chain shows a chromatographically abnormal βT-9 peptide. The mass-to-charge ratio value of its [M+H](+) ion, as measured by liquid secondary ionization mass spectrometry, is one mass unit lower than that of the normal βT-9. However, the electrospray mass spectrum of this peptide exhibits mainly a doubly charged ion, whereas the normal βT-9 gives a triply charged ion. None of the allowed single amino acid substitutions for a 1-u shift down (Glu → Gln, Asp → Asn, or Asn → Ile) can explain the suppression of one protonation site. This can be due only to the replacement of the internal histidine by a nonbasic residue. Thus at least two amino acid exchanges occur within the same peptide: one involves the internal histidine, and the sum of the mass shifts is -1 u. Consideration of the βT-9 sequence and taking account for the genetic code rules, the only possibility was (11)His → Tyr (+26 mass shift) associated with (14)Asn → Ser (-27 mass shift). This conclusion was consistent with the tandem mass spectrum of the [M+H](+) ion and was further confirmed by chemical microsequencing.
Short Bowel Syndrome (2000)

The short bowel syndrome is a symptom complex that occurs in adults who have less than 200 cm of jejunum-ileum remaining after intestinal resection. Similar symptoms are observed in infants and children following massive bowel resection or congenital anomalies and in individuals with longer segments of intestine with severe mucosal disease. Initial care should focus on a thorough excision of nonviable bowel, an exact measurement of the remaining viable bowel, placing all intestine in continuity at the initial or subsequent operation, and controlling initial food intake. With time, adaptation of the remnant intestine occurs, and absorptive function may be maximized by enhancing the enteral diet and minimizing parenteral nutrition. Growth factors and specialized nutrients may also enhance this process. Intestinal transplantation should be considered in selected individuals with the short bowel syndrome who fail intestinal rehabilitation protocols.
Differential Antibiotic Susceptibilities of Starved <i>Mycobacterium tuberculosis</i> Isolates (2005)

We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells. These drugs appear to target a process important in both replicating and nonreplicating bacteria.
High Fragmentation Characterizes Tumour-Derived Circulating DNA (2011)

Fragmentation and concentration of tumour-derived ctDNA is positively correlated with tumour weight. CtDNA quantification by Q-PCR depends on the amplified target length and is optimal for 60-100 bp fragments. Q-PCR analysis of plasma samples from xenografted mice and cancer patients showed that tumour-derived ctDNA exhibits a specific amount profile based on ctDNA size and significant higher ctDNA fragmentation. Metastatic colorectal patients (n = 12) showed nearly 5-fold higher mean ctDNA fragmentation than healthy individuals (n = 16).
Enzymatic Oxidation of Methane (2015)

Methane monooxygenases (MMOs) are enzymes that catalyze the oxidation of methane to methanol in methanotrophic bacteria. As potential targets for new gas-to-liquid methane bioconversion processes, MMOs have attracted intense attention in recent years. There are two distinct types of MMO, a soluble, cytoplasmic MMO (sMMO) and a membrane-bound, particulate MMO (pMMO). Both oxidize methane at metal centers within a complex, multisubunit scaffold, but the structures, active sites, and chemical mechanisms are completely different. This Current Topic review article focuses on the overall architectures, active site structures, substrate reactivities, protein-protein interactions, and chemical mechanisms of both MMOs, with an emphasis on fundamental aspects. In addition, recent advances, including new details of interactions between the sMMO components, characterization of sMMO intermediates, and progress toward understanding the pMMO metal centers are highlighted. The work summarized here provides a guide for those interested in exploiting MMOs for biotechnological applications.
Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: A phase I trial (2001)

The carbohydrate antigen globo H commonly found on breast cancer cells is a potential target for vaccine therapy. The objectives of this trial were to determine the toxicity and immunogenicity of three synthetic globo H-keyhole limpet hemocyanin conjugates plus the immunologic adjuvant QS-21. Twenty-seven metastatic breast cancer patients received five vaccinations each. The vaccine was well tolerated, and no definite differences were observed among the three formulations. Serologic analyses demonstrated the generation of IgM antibody titers in most patients, with minimal IgG antibody stimulation. There was significant binding of IgM antibodies to MCF-7 tumor cells in 16 patients, whereas IgG antibody reactivity was observed in a few patients. There was evidence of complement-dependent cytotoxicity in several patients. Affinity column purification supported the specificity of IgM antibodies for globo H. On the basis of these data, globo H will constitute one component of a polyvalent vaccine for evaluation in high-risk breast cancer patients.
Insertion of a Reversible Redox Switch into a Rare-Cutting DNA Endonuclease (2002)

Target sites for homing endonucleases occur infrequently in complex genomes. As a consequence, these enzymes can be used in mammalian systems to introduce double-strand breaks at recognition sites inserted within defined loci to study DNA repair by homologous and nonhomologous recombination. Using homing endonucleases for gene targeting in vivo would be more feasible if temporal or spatial regulation of their enzymatic activity were possible. Here, we show that the DNA cleavage activity of the yeast PI-SceI homing endonuclease can be turned on and off using a redox switch. Two cysteine pairs (Cys-64/Cys-344 and Cys-67/Cys-365) were separately inserted into flexible DNA binding loop(s) to create disulfide bonds that lock the endonuclease into a nonproductive conformation. The cleavage activities of the reduced Cys-64/Cys-344 and Cys-67/Cys-365 variants are similar or slightly lower than that of the control protein, but the activities of the proteins in the oxidized state are decreased more than 30-fold. Modulating the activity of the proteins is easily accomplished by adding or removing the reducing agent. We show that defects in DNA binding account for the decreased DNA cleavage activities of the proteins containing disulfide bonds. Interestingly, the Cys-67/Cys-365 variant toggles between two different DNA binding conformations under reducing and oxidizing conditions, which may permit the identification of structural differences between the two states. These studies demonstrate that homing endonuclease activity can be controlled using a molecular switch.
Intranasal absorption of sumatriptan and naratriptan: no evidence of local transfer from the nasal cavities to the brain arterial blood in male rats (2001)

Nasal administration to rats of small molecules (tritiated water, tyrosine, and propanol) results in a higher concentration in the brain arterial blood than in other arteries. The preferential distribution is based on a counter current transfer, which takes place between nasal vein blood and brain arterial blood in the cavernous sinus-carotid artery complex. This model was used to investigate whether the antimigraine 5HT(1B/1D) receptor agonists sumatriptan and naratriptan may also be transferred by the system. The ratio of 'head':'heart' plasma concentrations obtained from two carotid catheters after intranasal administration was not different from 1.00 for either compound, and thus, there was no experimental evidence of a preferential local transfer of drug from the nose to the carotid artery circulation. However, plasma concentrations increased from the first minute after intranasal dosing suggesting that sumatriptan and naratriptan are absorbed into the general systemic circulation from the nasal cavity in rats in a first-order fashion with no lag time. This is consistent with the clinical onset of efficacy of sumatriptan after an intranasal dose which occurs as early as 15 min post dose.
Hemolytic anemia in a cancer patient treated with recombinant interferon-gamma. (1990)

Currently, three classes of interferon are used in the treatment of malignancies. Interferon-gamma is the best studied. Bone marrow suppression as well as immune hemolytic anemia have been described. Heretofore, only bone marrow suppression has been attributed to interferon-gamma (IFN gamma). In this report, we describe a woman with lung cancer being treated with IFN gamma in whom acute hemolytic anemia occurred. Immune hemolysis did not appear to be the cause. We concluded that in addition to bone marrow suppression, hemolysis should be considered in a patient receiving IFN gamma in whom an unexplained drop in hematocrit occurs.
The Sentence Fairy: a natural-language generation system to support children's essay writing (2008)

We built an NLP system implementing a ‘virtual writing conference’ for elementary-school children, with German as the target language. Currently, state-of-the-art computer support for writing tasks is restricted to multiple-choice questions or quizzes because automatic parsing of the often ambiguous and fragmentary texts produced by pupils presents insurmountable problems. Here, we follow a different course by deploying natural language generation technology to evaluate and improve the grammatical quality of student output. Based on an abstract representation of the story under construction, all paraphrases of simple and combined clauses are generated fully automatically. From this source, the system produces exercises enabling the pupils to improve their sentences. We apply parsing technology only in the teacher mode, where new stories are entered into the system in a simple manner. The system we describe here is a prototype including a full exercise generation mode and a rudimentary teacher mode.
Facilitating foresight: where the foresight function is placed in organisations (2004)

This paper will introduce the Viable Systems Model and in particular the Meta System component of that model, as a framework within which to consider how foresight can be facilitated in organisations. It will show how the System 4 function within the Meta-System is in a position to facilitate processes that will produce effectiveness and the development of overall system identity. It will also show how adopting another framework for understanding the paradigms or worldviews that operate in organisations can enhance the likelihood that these processes will be successful.
801. Triterpenoids. Part XXII. The constitution and stereochemistry of masticadienonic acid (1956)

D. H. R. Barton and E. Seoane, J. Chem. Soc., 1956, 4150 DOI: 10.1039/JR9560004150
Towards a millivolt optical modulator with nano-slot waveguides (2007)

We describe a class of modulator design involving slot waveguides and electro-optic polymer claddings. Such geometries enable massive enhancement of index tuning when compared to more conventional geometries. We present a semi-analytic method of predicting the index tuning achievable for a given geometry and electro-optic material. Based on these studies, as well as previous experimental results, we show designs for slot waveguide modulators that, when realized in a Mach-Zehnder configuration, will allow for modulation voltages that are orders of magnitude lower than the state of the art. We also discuss experimental results for nano-slot waveguides.
An efficient XML index technique with relative position coordinate (2005)

Abstract:- Recently, a lot of index techniques for storing and querying XML document have been studied so far and many researches of them used coordinate-based methods. But update operation and query processing to express structural relations among elements, attributes and texts make a large burden. In this paper, we propose an efficient index technique with Relative Position Coordinate (RPC). It supports containment queries using SQL statements and data management operations. It does not cause serious performance degradations even if there are frequent update operations because it maintains relative relationship of XML tree. Overall, the performance could be improved by reduction of the number of times for traversing nodes.